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<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0RXS1</accession>
    <name>G0RXS1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome c oxidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0000180</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the assembly of cytochrome c oxidase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988030">
        <property type="protein sequence ID" value="EGS24087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690573.1">
        <property type="nucleotide sequence ID" value="XM_006690510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RXS1"/>
    <dbReference type="STRING" id="759272.G0RXS1"/>
    <dbReference type="GeneID" id="18254056"/>
    <dbReference type="KEGG" id="cthr:CTHT_0000180"/>
    <dbReference type="eggNOG" id="KOG4618">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_157422_0_0_1"/>
    <dbReference type="OMA" id="GGDRDMC"/>
    <dbReference type="OrthoDB" id="9971592at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033108">
        <property type="term" value="P:mitochondrial respiratory chain complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051040">
        <property type="entry name" value="COX23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46811">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46811:SF1">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS24087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="76" mass="9081" checksum="9975D87DFE8CBF90" modified="2011-10-19" version="1">MVSTGDPWTPETREKFEKKDRSAYLDPCQEAAARSIRCLHRNNGDRTMCSDYFQAYRDCKKAWLEQRKKEKKGWFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G0RXS5</accession>
    <name>G0RXS5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">T-complex protein 1 subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0000220</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988030">
        <property type="protein sequence ID" value="EGS24091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690577.1">
        <property type="nucleotide sequence ID" value="XM_006690514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RXS5"/>
    <dbReference type="STRING" id="759272.G0RXS5"/>
    <dbReference type="GeneID" id="18254060"/>
    <dbReference type="KEGG" id="cthr:CTHT_0000220"/>
    <dbReference type="eggNOG" id="KOG0363">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_6_2_1"/>
    <dbReference type="OMA" id="CAEMVMS"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03336">
        <property type="entry name" value="TCP1_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000002">
        <property type="entry name" value="T-complex protein 1 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000045">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012716">
        <property type="entry name" value="Chap_CCT_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02341">
        <property type="entry name" value="chap_CCT_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS24091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="530" mass="57042" checksum="5A88DDD8982E1D3F" modified="2011-10-19" version="1">MSSFSPTQIFEEGTTEEKGENARLSAFVGAIAVGDLVKSTLGPKGMDKILQSASTGEIMVTNDGATILKSIALDNAAAKVLVNISKVQDDEVGDGTTSVAVLAAELLREAEKLVNQKIHPQTIIEGYRIASQAALKALEASAVDHSNNPEQFKKDLQAIARTTLSSKVLAQDRDHFAKLAVEAVLRLKGSSDLSHIQIIKKAGGKLCESYLDEGFILDKKIGVNQPKRLEKAKILIANTPMDTDKVKIFGARLKVGSTSKLAELERAEREKMKAKVEKIKAHGINCFINRQLIYNWPEQLFTDAGIMSIEHADFDGIERLALVTGGEIASTFDHPEQVKLGYCDLIEEVMIGEDTLIKFSGVAAGEACTIVLRGATDQLLDEAERSLHDALAVLSQTVKEPRTTLGGGCAEMIMAKAVEAAATRVEGKKQTAVAAFAVALRQLPTILADNAGLDSGDLVARLRKAIYDGLTTYGLDLMTPGGGIADMRELGVIESYKLKRAVVSSASEAAELLLRVDDIIRAAPRKREKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G0RY18</accession>
    <name>G0RY18_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">4-hydroxybenzoate polyprenyltransferase, mitochondrial</fullName>
            <shortName evidence="11">4-HB polyprenyltransferase</shortName>
            <ecNumber evidence="11">2.5.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Para-hydroxybenzoate--polyprenyltransferase</fullName>
            <shortName evidence="11">PHB:PPT</shortName>
            <shortName evidence="11">PHB:polyprenyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0005080</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>an all-trans-polyprenyl diphosphate + 4-hydroxybenzoate = a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:44504"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:9564"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58914"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="2.5.1.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Mitochondrion inner membrane</location>
            <topology evidence="2 11">Multi-pass membrane protein</topology>
            <orientation evidence="2 11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.39" evidence="11"/>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691046.1">
        <property type="nucleotide sequence ID" value="XM_006690983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RY18"/>
    <dbReference type="STRING" id="759272.G0RY18"/>
    <dbReference type="GeneID" id="18254546"/>
    <dbReference type="KEGG" id="cthr:CTHT_0005080"/>
    <dbReference type="eggNOG" id="KOG1381">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034879_2_1_1"/>
    <dbReference type="OMA" id="WCMIYDT"/>
    <dbReference type="OrthoDB" id="18170at2759"/>
    <dbReference type="UniPathway" id="UPA00213"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008412">
        <property type="term" value="F:4-hydroxybenzoate polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1780:FF:000001">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000003">
        <property type="entry name" value="4-hydroxybenzoate polyprenyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01635">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006370">
        <property type="entry name" value="HB_polyprenyltransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01474">
        <property type="entry name" value="ubiA_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS23804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="415" mass="44821" checksum="8162967010855234" modified="2011-10-19" version="1">MSTSRLLARLPLRRGLIPSSRTFSSYSLNHISSPCRNLFIRRRLALASYQNAPKALVTYHTTSSLSASTTPNDTRENPIPPAEYRPPTTGLLSYLPPSWVPYAELARLDKPAGSYYLYFPCIFSTLLAAPLANPIAVPTTVISTSLLFLAGAIIMRGAGCTINDLWDRNLDPHVARTRLRPIARGAVTPFQALVFTGGQLLAGLVVLLQFPPACFWYATPSLLLVATYPLAKRVTYYPQFVLGLTFSWGAIMGFPALGVDLLSNGTAAAAAGLLYSSNVAWTVLYDMIYAHMDIKDDAKAGIKSIALKHEKETKQVLTGLAITQVALLAGAGIAAGAGPAFFVGSCGGALATLGYMIYKVNLKSVKDCWWWFINGCWFTGGAICFGLGADYLLQYTQGKKDLAQAEKEVARTESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYY7</accession>
    <name>G0RYY7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0001040</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690657.1">
        <property type="nucleotide sequence ID" value="XM_006690594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYY7"/>
    <dbReference type="STRING" id="759272.G0RYY7"/>
    <dbReference type="GeneID" id="18254142"/>
    <dbReference type="KEGG" id="cthr:CTHT_0001040"/>
    <dbReference type="eggNOG" id="KOG2539">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007075_0_0_1"/>
    <dbReference type="OMA" id="CTNHSTC"/>
    <dbReference type="OrthoDB" id="421327at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052571">
        <property type="entry name" value="Mt_RNA_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015324">
        <property type="entry name" value="Ribosomal_Rsm22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184:SF5">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09243">
        <property type="entry name" value="Rsm22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="262"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS23415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="931" mass="104731" checksum="25A48F4834346A06" modified="2011-10-19" version="1">MLSAGKMQHRCPGCRAQLLTFYDVLLPRSTRASAQPLLHRRLHTPHSTTPRALPSVAARSWRSNSLRAFSTTHPVRQEPVQESSSTADVPATTRTQEEIETFVRHARQTFGLTLPADYLTPEEYKVYERLYGPPLRETTPEDVGIPARTANAQKPDGSVQKPFLLRDVAGGLAEEVPYAVSVDPNVAIEAAREAARQAAAEEGVEMSEEEMDAEIKSMLEEGLLSLPGTSEPVHVDWIQATANNEREYEALVKLQRDFEEAARRARTMPPPAEDTHEEESIIEEDEPREEEEIDEDESDPDAVFFPEDGHIDSRLHPYTSLGKFRTFPSTIHIPKATFVEPISELLKRTDTVHIRECAERVFGGPGLPYSPMTPKSKSNLPQKPVQLEAGFHRMSAIEADTYLATVLPPVYASIMSVLVEVRKRLGSKWLRDMLLRKDGPRILDAGAGGAGLLAWEDVLRAEWEVLREEGKVSPRRYGPPGKKTVVIGNENLRHRVSRFLDNTTFLPRLPDYLHSVMRAQEELDSGGKPQPHKVFDIIIVSHMLMPIDKEHKRREFIDNLWTMLEPKGGVLIVLEKGHPRGFEAVASVRDQLLDKYILPPHQHPREADFIPNGDESESRPREPGMIIAPCTHHHKCPMYLTPGLSQGRKDFCHFTQRYLRPPFLQKVLGATHKSHDDIEFSYLAIRRGVRDIQGETLAPSGAVLLTGQEANNRAFVGYGNGREQSEKEETTVPHPLSLPRNILPPIKKKGHVTLDLCTPAGTLERWVVPRSFSKQAYHDARKAAWGDLWALGAKTRTIRTARVGRGVVEGERKGKNKQEPQRKNPRTVHVNVHPKLGVLGARFASDGSDATGAVEDYIDKKGGKKKLVKMRIEEVMERLGEAGYEDAGVVDAEEVRREFREELRREMGEDDDADLRELEEAARRLNIDKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZ88</accession>
    <name>G0RZ88_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0002100</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="476" last="476">
            <title>High-resolution structures of a thermophilic eukaryotic 80S ribosome reveal atomistic details of translocation.</title>
            <authorList>
                <person name="Kisonaite M."/>
                <person name="Wild K."/>
                <person name="Lapouge K."/>
                <person name="Ruppert T."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="35079002"/>
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    <reference evidence="12 13 14" key="3">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e56910" last="e56910">
            <title>Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation during pre-60S biogenesis.</title>
            <authorList>
                <person name="Lau B."/>
                <person name="Huang Z."/>
                <person name="Kellner N."/>
                <person name="Niu S."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
                <person name="Cheng J."/>
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        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e57984" last="e57984">
            <title>Structural insights into coordinating 5S RNP rotation with ITS2 pre-RNA processing during ribosome formation.</title>
            <authorList>
                <person name="Thoms M."/>
                <person name="Lau B."/>
                <person name="Cheng J."/>
                <person name="Fromm L."/>
                <person name="Denk T."/>
                <person name="Kellner N."/>
                <person name="Flemming D."/>
                <person name="Fischer P."/>
                <person name="Falquet L."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
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    <reference evidence="10 11" key="5">
        <citation type="journal article" date="2023" name="Nat. Struct. Mol. Biol." volume="30" first="670" last="677">
            <title>Structural inventory of cotranslational protein folding by the eukaryotic RAC complex.</title>
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                <person name="Kisonaite M."/>
                <person name="Wild K."/>
                <person name="Lapouge K."/>
                <person name="Gese G.V."/>
                <person name="Kellner N."/>
                <person name="Hurt E."/>
                <person name="Sinning I."/>
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    <reference evidence="15" key="6">
        <citation type="journal article" date="2024" name="Nat. Commun." volume="15" first="716" last="716">
            <title>Methionine aminopeptidase 2 and its autoproteolysis product have different binding sites on the ribosome.</title>
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        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
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<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
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                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="743"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="752"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="907" mass="97338" checksum="99D56FBFACB96DE8" modified="2011-10-19" version="1">MSSSVIKPGTPSKPGQGSFPPTSQSILRDKLTRRSSPDSEALASSDEEGELPPLENPTPPVQPHKPVRRSSWLNETSQPPLLTQRKGSFASSTMSPTASHPSTPAGESGVAGWSTHPALSRIHTGSSAFPWSSGIWNNDSKKDAASRLAEVVPSPTSTVPPGSSGNSFFSESGATQASPGPRDPPNSQIPFAIPLHPTPKAYRSQSYSVGQLEPDAAIPSLTASSILGSRSSRLPHGLHHRPSRPSMLSEMSSEGMLGKVNEDDDDTSSGSIHGSQQHQDPAKTIEMLQRENMMLRQQQQQLQSARLRPRASTSGAFGLSHSYLHQEPLPEESDYAVDDELNEVSDLAGRRSLARRMSEFGAGPFRNPYLLENKKLENVKKGIWQSSLGFGGLPELPQSRRHSFADVPIPTRQASISSMSEAAKAHEAAAREEAAQAQELHSAYPENHNMAVSSQVAPYFTGGSLLGPQQSLNQAAYNQFPAPSHYSGLSAPYSNRTGSPHRNMYGMSQSGPRRDQPLHIVLFKCSRADVFYIQEGTGLTVKPGDLVIVEADRGTDLGTVARDNVDWQTAKELKEHYAEEQYKWLMMYSQNAAAAHDGVNAGLMASSNGLHGSAVGGMGPPHHHHFQDPNAGELKPKLIKRLAQNHEILALREKEGNEARAKRVCQQKVKEHGLDMEILDAEFQMDWKKLTFYYFANTYINFNALVTDLFKIYKTRIWMSAINPASFANPHLGLQAPSGVGPGAVVNRGPAARRQQQQEAQQESHAAYSTSNQPGRGLLPAPYGPERPPALGSNFANNNYAYTNPYAAFGNAVLGNNALGNAAAATAAASHPAGGISPYGAGMTQGLDGFGSSTYQQGGTVDFAARARFPSPQPAAGVAQHDQAALASLGGQGDLLGSFQGLSLNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZC5</accession>
    <name>G0RZC5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0002480</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690795.1">
        <property type="nucleotide sequence ID" value="XM_006690732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZC5"/>
    <dbReference type="STRING" id="759272.G0RZC5"/>
    <dbReference type="GeneID" id="18254286"/>
    <dbReference type="KEGG" id="cthr:CTHT_0002480"/>
    <dbReference type="eggNOG" id="KOG1940">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013368_4_2_1"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16464">
        <property type="entry name" value="RING-H2_Pirh2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039512">
        <property type="entry name" value="RCHY1_zinc-ribbon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017921">
        <property type="entry name" value="Znf_CTCHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037275">
        <property type="entry name" value="Znf_CTCHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21319:SF0">
        <property type="entry name" value="AND RING FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08900)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21319">
        <property type="entry name" value="RING FINGER AND CHY ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14599">
        <property type="entry name" value="zinc_ribbon_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161245">
        <property type="entry name" value="Zinc hairpin stack"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51270">
        <property type="entry name" value="ZF_CTCHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHY-type" evidence="4">
        <location>
            <begin position="492"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="CTCHY-type" evidence="5">
        <location>
            <begin position="561"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="627"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="203"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="302"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="402"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="740"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="820"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="302"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="767"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="787"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="820"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="868"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="910"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS23553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="943" mass="104326" checksum="79FC4AF5D78413C5" modified="2011-10-19" version="1">MKPAGREPAKEFEFSVYSWDIDFEIPATGTNAGSAEHLGTLVSEQQVQNMPNTIMLNEMIASDLELIKDTDWTQMGRNVFFADISLPYGRTLCLGTTHLESLQTNPPHRPAQLALAARYLRDEDVDVGVQTGDMNAIQDFDRTLPAENGLNNAHLVTGEVEGAVEGMMWRQMAKSPQREEFWLSRMVSEFIISPVLRQARRFSSGFGSDDTRTRQQGQDSQEQQQCPRPVSSSSNRGSAVAGNPSTNVILEDSEDGGCSDVTGAPVNAGAHASSRDPPPTRVASVTAWSDSARLTQDDITAAASDTDTTSPDSVQQPSTSSAPPTSSSALPQSETTPASQVARESWTLSETARRDPLPEDDGMGDLRRRIHAIQATDAPQEVKARMLHELLMEKYNKSQKKLSGASLATMRPESPLSPGKSILGTSPAPSEQKSAGPLQQALRFLNSFAEPAELNVPLTDDDLRPTYAPTPPPDSAEWDLDILHGGDDLDTEPLRYLGCKHYRRNVKMQCATCERWYTCRFCHDEAEDHVLPRHQTKHMLCMFCGCAQKVSDSCVRCGRSAAQYYCGICKLWNNDPNKPIYHCSDCGICRVGRGLGKDFFHCKRCMACISMSATNHKCIERSKDCDCPICGEYLFNSPKPVVCMECGHSIHRHCLEEHKKTSYKCPLCNKTCVNMETKFRNFDLAILTQPMPPEYRDARAVISCNDCSAKSQTPYHWLGLKCAVCNSYNTTQLQLLNMPGSWSEHDRQRQQETSSSHQQPVALDPEVILRELRRQQRAAAREREQRQSQQSEATPLSTSPSSSYSPAFLLRLLQSMQPFSSSSSNAAADPPSPPASTTEASSAALPASTTAKAVSASSPTPLPTNDPPENEDEEEEEEEEEDEDPLTLFGVFDHHDRSRDWSSPLASGGEEADEEEEEEESEEEEEEEEGEDEEDEILLVGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZM5</accession>
    <name>G0RZM5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cellular morphogenesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0003490</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690895.1">
        <property type="nucleotide sequence ID" value="XM_006690832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZM5"/>
    <dbReference type="STRING" id="759272.G0RZM5"/>
    <dbReference type="GeneID" id="18254387"/>
    <dbReference type="KEGG" id="cthr:CTHT_0003490"/>
    <dbReference type="eggNOG" id="ENOG502QQZD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005863_0_0_1"/>
    <dbReference type="OMA" id="NMYTPGC"/>
    <dbReference type="OrthoDB" id="2503993at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902929">
        <property type="term" value="C:plasma membrane of growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024982">
        <property type="entry name" value="Rax2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048266">
        <property type="entry name" value="Rax2-like_second"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048265">
        <property type="entry name" value="Rax2-like_third"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31778">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN RAX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31778:SF2">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN RAX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12768">
        <property type="entry name" value="Rax2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20842">
        <property type="entry name" value="Rax2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20843">
        <property type="entry name" value="Rax2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1175"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like second" evidence="3">
        <location>
            <begin position="239"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like third" evidence="4">
        <location>
            <begin position="399"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like C-terminal" evidence="2">
        <location>
            <begin position="916"/>
            <end position="1166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS23653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1247" mass="131672" checksum="C18C49C9430256AE" modified="2011-10-19" version="1">MRLSFARRQAAPSYATASLIPFTISLLSSVAVSPATAITFNPVPSANLDLSRLGRVAFAGDFTGISLYQFEGQSEHPYRTNGSEQLLARMPNGVLAPIIDTDATIRAMCTLDTNNGTVVVLGGNFTSIRRSDHDGRALESTGMALFDPATATVTPLPGLTGQVNALYCDQKSKTVYVGGTFVNANSTNAVAWQPGKGWINLPFAGFNGPVTSITKAPNGNVIFGGSFTGLGNTSTPSTPDSQVINLGSAHITGVSSTTVGGFSDPRAIICKRAGEDGPGNTWLLHDNTPGAWQARFRFGFRPTKLRLYNAHQDGRGTKTWRFTALPINGIMNFTYIDPETGQNASCTNQCPLSHNKSVLFQDFHFVNEIGMNEFRIDISEWYGAGGGLNGIELFGDDIFAYAINDFNEPTCAGIKFPSQATATGPWYVSPSRESNTEYLSAQLMAPITESSASVVFEPDIKESGYYAVNLYTPGCLQDNSCTTRGQIRITGKMTADPTKSQPIEVDLYQTNNFDKYDQIYLGYIDASSDSFRPAVTMTPLAGQPLNVMTFVAQRVGFTLINSTGGLNGLYEYEPGKRVNANEFVKSAFNRLGSSFTSGSAVSALAASSDATYIAGNFSSSSARNIVALRASDASIQSLDGGLNGKVDSMFLDGTSLFVGGSFTSTMDNSTKGLNNVAVYDTVKDTWSPLGAGVNGHVRRVVGMTMNITGSTPEVVVSVSGVFNQTLPFSNNPAVEVDGLAVWVPSQNNWLQNLDLPVEYIQGILSASILNFTGGPSLYAGSVSSFSLATKGAAILQGETLGRVAVDIRRSMDSIISKKQDGDSTTDVINGVVAGVFDTRNGRNLTILAGHFTATATNGSTIHNLLILDGSKEDEVIGIGGQIASNSTFEALAIHGDVLFAGGRVTGNVNGVEVNGLVTYNLATRAFNTQPPALTGGNGTVTSIAVRDSTGDVYVGGTFQLAGSLECPGVCFYSTSASQWNQAGQNLEGSVSSLMWATNNILLAGGNLLINGTTPSFLAHYDATQQAWDTYPGADQLPGPVTVITAGTSDGGQVWVSGVSSDGTPYLMKTDGSGTWQRAGQSILMPGTTIRGLQILSLAKSHPDSPLLHRDEALLLTGSILLSNFTGSTASAVLFDGTSFTPYALTTNVGNQPGSISRIFSERSDFFAKGRGRMPLVFVVLISLAISLGLVLLIVVAGLVLDRIRKKREGYVPAPTSMYDRGSGIQRIPPAELLEGLGRGKAAAAPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZU4</accession>
    <name>G0RZU4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0004230</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690964.1">
        <property type="nucleotide sequence ID" value="XM_006690901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZU4"/>
    <dbReference type="GeneID" id="18254461"/>
    <dbReference type="KEGG" id="cthr:CTHT_0004230"/>
    <dbReference type="eggNOG" id="ENOG502RAYN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_619817_0_0_1"/>
    <dbReference type="OrthoDB" id="5238281at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="21"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="102"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="414"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS23722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="467" mass="48944" checksum="A5C80B60A08D1020" modified="2011-10-19" version="1">MRVTAPSLRRRNHAWRQMRALEKRGFRVRRHGDEDHANDEDDADHDDHSEDSDSASSDEESDFEDEPSTTIMLSSTSTIFATVPVRTGSLGAVILPTIPAAAPTTPGVALGAEEPNEIGIDDPETDSDSDDETTTLPPNITQSPPQPSFLPSPPDVTGSPSESISTTSLAGSESTSTPALTETPPTATASSSLPAGGNIGTGSEASPSQTPGTLPGPDLSAGVDVGAEVKDDKLSGGAVAGIVLGVLLSLGLIAGALFFWCKRRRDKGLPFIPFGWGSLGSRSSTPDITAPLPGKIGGPNHAKTNTQIMDELIRAAYASESGGNVIADEAAGYYDYNEKKRMDSQQPPHLSLNLPTAPQSANDNGNPFLDEQTYIALAGRLTPQPPQQARTQSVATEDKPVMQWLEEVRPPTQVGIPPASPSVPPSATLPRPVAGNGSGATRIVEPPQPAYFGRYTMTTESSGARWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G0S000</accession>
    <name>G0S000_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Glutamate decarboxylase</fullName>
            <ecNumber evidence="3 8">4.1.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0008220</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-glutamate + H(+) = 4-aminobutanoate + CO2</text>
            <dbReference type="Rhea" id="RHEA:17785"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="4.1.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.15" evidence="3 8"/>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691352.1">
        <property type="nucleotide sequence ID" value="XM_006691289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S000"/>
    <dbReference type="STRING" id="759272.G0S000"/>
    <dbReference type="GeneID" id="18254860"/>
    <dbReference type="KEGG" id="cthr:CTHT_0008220"/>
    <dbReference type="eggNOG" id="KOG1383">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_343546_0_0_1"/>
    <dbReference type="OrthoDB" id="5152799at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004351">
        <property type="term" value="F:glutamate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000017">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.50:FF:000001">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010107">
        <property type="entry name" value="Glutamate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01788">
        <property type="entry name" value="Glu-decarb-GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321:SF3">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="507"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="698"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="507"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="707"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS23161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="824" mass="93575" checksum="4B62DF4A4569311B" modified="2011-10-19" version="1">MSLARHVNPEDIIHHLQHEDTGPLIAQAIPGSSHLTPFSTPYASRRDIPKYRIPQHGTPGDTVYQMLKDELDLDGRPNLNLASFVNTYLEDNAKSLLSANANKNLADNDEYPALLDLSKRCVSILAHLWGVQKGEKAVGSPTVGSSEAIHLGGLAMKRSWQQRRREQGKDASRPNIIMGANAQVALEKFARYFDVEARILPVSAKSKYRLDPELVRENVDENTIGVFVILGSTYTGHYEPVEEVAQVLDEYQKNTGIDIPIHVDAASGGFVAPFTFAGAGGAKWNFEIPRVHSINTSGHKYGLVTAGLGWIIWRDEAYLPQDLIFKLHYLGGTEESFTLNFSRPGAQVVVQYYNFIHLGFDGYREAMENCLANARMLSKSLEETGWYTCVSDIHRPVQGKREPKGGETSASYVAGLPVVSFRLTDDFRRQFPHIQQETISLLLRARQWIIPNYALPPNVNSTEILRVVVRVNMSLDMLDRLITDIVQVTEMLMERDEVDLSVLKEQRERREEVQEKDKEHRRQKHRRDKVEGVEKKRMEEGIHRGPVPTEFIHPNQIFFKETTTSIYQERRRPRGELVALGEVLPRQEGETLGQWISRLEMVRDMTLDWAEQYEMSKLASRLGSRSASPENLDYFYSKQSPQVHLPTLWKLCGAIPREFPQDEDKIEEVAARSTDEHYLARFTTIFRNALSKSQVRISSLAPGSPPGQLTQGSDIEPTTNQRPRAPALKKATDSLIIHRNRKLFKRALKFLDRFPDDEEAQEEYITLWLEDTHLRSKDTSQVTLHAALISSKIDSSNDEGNDMDESSFLDFDLDGWIEKCFGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0S094</accession>
    <name>G0S094_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0009220</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691446.1">
        <property type="nucleotide sequence ID" value="XM_006691383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S094"/>
    <dbReference type="STRING" id="759272.G0S094"/>
    <dbReference type="GeneID" id="18254960"/>
    <dbReference type="KEGG" id="cthr:CTHT_0009220"/>
    <dbReference type="eggNOG" id="ENOG502SDRZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008005_0_0_1"/>
    <dbReference type="OMA" id="LNVMEGN"/>
    <dbReference type="OrthoDB" id="3438840at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="301"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="348"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="524"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="646"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="971"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="303"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="375"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="473"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="529"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="544"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="660"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="694"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="713"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="797"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="820"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="858"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="910"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="929"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="978"/>
            <end position="991"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1008" mass="109060" checksum="3B5147DDB68A1462" modified="2011-10-19" version="1">MAAMEAANAHYQNGHHQQSGPPLPASPTLTNPDMILPDYERSDSPDTLDLNRGHPSLEMWKNTQPAAASSIHHMFTATSMGGPPYRPVGPITPTTPIIYGNGTMLSDIGEVTEVESTIEEKPSPPRTKPSSGRRSNSPGRTGDNNEALRPSPTRKGTPTLRKSKQSLRAARERRDSIDSNSTITENHKAHYADIDDSASVGDSVFQGDDEQSVASSYMEGTDPNRLGASKIDNSDRLSTYSTSSLSRRAEEILANAKKRLSAMEGNLNRARSTLYSTSRFGLNSATSSTTVSPFQRTVSATYSRNSSVDSTTSSSNQPTAGHTRMSSDIAMRNGLPYRVSIPRSQSALGAAGGYRQPLTTSKSSDHIRQELGYESSYSSRTSRSSISVREPGVKPLTEEEVRRLGEADPATQNARLEAFLNPDPTHESTPRHPLRSPTAAQVQDIKEQMRDLKGKISTLREQARADSLKRRSLQSLRTPSPFTHSQLEQWYAEPRSNRASVLGPSSFSNRSFWNSEDSSVTSEFKDDFSQSADQPTRQTQYVKSESTSSLESPASAMPDVSSPVSFRGSEPGLHSEANEDYSDMATENGEYDENTDEQAQTAEEGPADSVSESGESLYHDAVQFQIRHEDREDAFDYEHFFLHSAMGTMSQELMRRRDSTSSYSSEGSVETTRGPVTVSETESETYAPRRRNSDASVSTFETFATAQERHSIKSPQFDESSRAASVQSVRYRSGSSAAAKRLSLPAASASHQPGARDSDGSISPIAEETSSSPHVHTSTRRGSVIHRPISAQAAIRGSSSIASFDSVGTNRSFPLVNKPSVSIPPRAASAAAVARGHSHSGSTTTAKKAHSTGVLTPRGGSMSSGSSRGSRSRDDDNEDDDDDWRSVTARLMSEAIAQLNRQQLRKKQGHVAQGSVSSSAAGDRNASTRGEKEESTEREKHDLLAGLPREDSSESRMFRRRIEAARRALEGYGPGLDNSASVGYTPSTSTLADLDGAEEGSPSSGNGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0C1</accession>
    <name>G0S0C1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Replication factor C subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0009490</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691473.1">
        <property type="nucleotide sequence ID" value="XM_006691410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0C1"/>
    <dbReference type="STRING" id="759272.G0S0C1"/>
    <dbReference type="GeneID" id="18254987"/>
    <dbReference type="KEGG" id="cthr:CTHT_0009490"/>
    <dbReference type="eggNOG" id="KOG0989">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042324_1_0_1"/>
    <dbReference type="OMA" id="GCQSGSF"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000011">
        <property type="entry name" value="Replication factor C subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000237">
        <property type="entry name" value="replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF20">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="66"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="9"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS23282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="384" mass="42381" checksum="ED9E9A6D85D39930" modified="2011-10-19" version="1">MANFFDLKARRAAQSNGTASTSTEKQTAEHTRAQPWVEKYRPKTLNDVTAQDHTVSVLQRTLQASNLPHMLFYGPPGTGKTSTILALAKELYGPELMKSRVLELNASDERGISIIREKVKDFARTQLTNPPPGYKTKYPCPPFKLIILDEADSMTQDAQSALRRTMETYSKITRFCLICNYVTRIIDPLASRCSKFRFKSLDQGNARKRLEEIAQLENVGLADGAVDALIRCSEGDLRKAITFLQSAARLVGASQAAQGDSEDGDKMDVDKTLVTAKIVEDIAGVIPDDTIQKLVKAMRPRATGETYSAIAKVVEEMVADGWSAGQTLAQLHKAIVYDETIPDTQKNKIVMVFSEIDKRLVDGADEHLSMLDLALRISGILASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0E3</accession>
    <name>G0S0E3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0009710</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMCO4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691495.1">
        <property type="nucleotide sequence ID" value="XM_006691432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0E3"/>
    <dbReference type="GeneID" id="18255009"/>
    <dbReference type="KEGG" id="cthr:CTHT_0009710"/>
    <dbReference type="eggNOG" id="KOG2385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001695_1_0_1"/>
    <dbReference type="OMA" id="KEVGWEV"/>
    <dbReference type="OrthoDB" id="277931at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007941">
        <property type="entry name" value="DUF726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF3">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="483"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="64"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="336"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="883"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="920"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="835"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="346"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="961"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1007"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1039"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1064"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1117"/>
            <end position="1127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS23304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1127" mass="122946" checksum="91B9BCC2BCFCF728" modified="2011-10-19" version="1">MPSIDGTSAGSDHQKAPLNPIATPANSTTTQQQHVSASETLATTMTVELDDFGLPVRKYPAATEKAAASLAEVEPAEPKTEDATTQNKRVPGESGASQPKPIEDQAIAESKKTLGMVPGHRRDESSASHQQLTSYQPAEKKDEEDDDGGWQDMPSYAPYDIYDDNNKLIAREYHESEDEKYGYAALGGAGKGYTKILDDDAESVTSMDENMQYLFKEMGPSTSAMDDEQRDAVSQLQATKELLTEGQRIAYVGLTRLELNAMIQELESLPMPTSKVKKYVGMAAENMKMWAQRMMIRLYTHMDISPDEQVMIEQLSSHGVQPRDLTPVLMANARVKNPMVVDDDQSSTARTSSSSRPSSVMGSEKEPRSDSPPPYSAEDTSELKEEVRTPSQMPTTQKIDIDIRWTVLCDLFLVLVADSIYDARSRTLLERVAKDLDISWLDICRFEKKVTDALEMQQSADKENWNEQEHMENRRKMALKKRYMMVGLATVGGGLVIGLSAGLLAPVIGAGLAAGFTAIGVSGTGTFLAGAGGAAIITSTAAASGSVIGGRAADRRTGAVKTFEYRPLNNNKRVNLIVTVSGWMTGKVDDVRLPFSTVDPIMGDIYSVLWEPEMLATIGATINILATEALTQGLQQLLGNTILVSLMAAIQIPVILTKLAYLIDNPWAVSLDRAEMAGLILADSLIDRNLGTRPVTLVGYSLGSRVIFSCLQELARKGAFGLVQNVYLFGSPIVVKKDEYLRARAVVSGRFLNGYNRNDWILGYLFRLTSGGIRRVAGLAAIEDIPGIENMDVSDLVVGHMDYRTAMPRLLRECGWMVESDEFTEIEDPDPDGHRERQRELINEIEEARRELEKESKQNKSSGFAFWKRRKVPERQEWEVYEDTMKAGNKGKSEEKDGGGIDPLDEQLLQIREIKSTLPPIKVELNKNNTPTTTTPPPPPTAKAKSSRCSLADGSIMTDLSRSSSSHQTSTSSPKPTGRDRAPTFPSSKVDNTTPSSTSSPYRSYGHGFGGFGGGYVNYGEPEDPANDGITMTFDTGFDDDRDRQGDKDSGPGLFSPQPASLNAGISSDASGSGAGNSSSMQPPESILGLTKPATVPNITLADPWRDAGYDDDEEFGKEKEISLTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0J3</accession>
    <name>G0S0J3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0010220</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691545.1">
        <property type="nucleotide sequence ID" value="XM_006691482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0J3"/>
    <dbReference type="STRING" id="759272.G0S0J3"/>
    <dbReference type="GeneID" id="18255060"/>
    <dbReference type="KEGG" id="cthr:CTHT_0010220"/>
    <dbReference type="eggNOG" id="ENOG502S93S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006885_0_0_1"/>
    <dbReference type="OMA" id="QAQIQMT"/>
    <dbReference type="OrthoDB" id="5396252at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42068">
        <property type="entry name" value="YALI0B18964P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42068:SF1">
        <property type="entry name" value="YALI0B18964P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="804"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="483"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="831"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="857"/>
            <end position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="882" mass="95596" checksum="F4BD2BB9718376A3" modified="2011-10-19" version="1">MPRFSVTFGRRKSTADNLDNAPVTPSFRVLERSEVAGAKQVDGGVKPVNQGFHRPTGSDVTFEDNIFADLKPNRGSGSSNTTKTTLTDISSRHSNASTTPSSTDMGGIEDSRGGQKKLPSDVPVPPIPKSSATTGFLRAAGRTFSFGGQKKHQLAQPTITESPPATSESDPKTPSNGRSRAATTSTTTTLTPPRVDSDFELDLGGDFGKLVLGSDHRSSVVTLKNDQYSVQAPAPRSLTGSRPNQPSPLQFDNSVKVDPPLRSWSSQHSNDQLIAPSPTTSPAFKDNAPAVSCILRESSPITERPRPGTSPEFGSRKPALSPQQSNLEQEEDAEDEETRLLKDSLSTVTKFLNGTEAPMTSGTTYRRDGSTLEADSDSLFDSTSSRYGSRYTSRKHQGPPTTNKVMTPAEFERYRRDKEQQDRERREHNKFSGKNNRDEDEEDNYEDDEDDLEKARQQAKQRQKQEAHLAVYRQQMMKVTGESSSRLSIQMSSSTPALTTTITTPAAGPANGSDNSDEDEDIPLAVLAAHGFPNKNRPPNRLSTMMSNPNLRAAQQPSYQRPGSAIGDVPGVGNARLPAFARNLPQDPFIGAGLIRNPVRESFSLGGGAPGIPPGGLIGVIANEERNRAMRRGSPHLEGPTVLPYGSGGLDPVTGIPSHQAYQGNRHSMMQMNQQMQQFMQMQMQFMQTMMANQQNAPMASVSATNLNAMGTMQQSPGMLGVRMPEARHSFIANDSRLDIPFGRGEAQMRTMSMVQPSSASWIQPGQPVGYAPSIRPQGNAYAPSIAPSERSNIGLPGRYRPVSHMPPPHLVPEQGHLRKSSVMSGAPQHPSISVTNVTSDSGNASDDDEEGWAAMKAKREKKKSLWRSKKLGGDNLDSLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0Q1</accession>
    <name>G0S0Q1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0010820</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691603.1">
        <property type="nucleotide sequence ID" value="XM_006691540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0Q1"/>
    <dbReference type="STRING" id="759272.G0S0Q1"/>
    <dbReference type="GeneID" id="18255120"/>
    <dbReference type="KEGG" id="cthr:CTHT_0010820"/>
    <dbReference type="eggNOG" id="ENOG502SJXH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083369_0_1_1"/>
    <dbReference type="OMA" id="TKNCQLH"/>
    <dbReference type="OrthoDB" id="152248at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025649">
        <property type="entry name" value="DUF4360"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38847">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38847:SF1">
        <property type="entry name" value="PSEUDOURIDINE SYNTHASE RSUA_RLUA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14273">
        <property type="entry name" value="DUF4360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409176" description="Secreted protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="23252" checksum="17A3CBA16EFB69E8" modified="2011-10-19" version="1">MRFTAAAALVLPVLAAASPIANPSVVPDGWADTPDPNDIQIVSATFSGSGCPQGSVSTSISPDKTVITFGFDKFQTYIGPGTTIADRTKNCQLHLNLKYPGGFQFAVVESTYHGYALLEEGVTGTFFSTYYFSQDAKATTTTQTTITGGGIWAAGQVYTKSDKIPTASYIYSPCGASGILNINNRIALTSTNPNAFGMITDDDATIAFTQQLNIAWRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0T1</accession>
    <name>G0S0T1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0011130</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691633.1">
        <property type="nucleotide sequence ID" value="XM_006691570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0T1"/>
    <dbReference type="STRING" id="759272.G0S0T1"/>
    <dbReference type="GeneID" id="18255151"/>
    <dbReference type="KEGG" id="cthr:CTHT_0011130"/>
    <dbReference type="eggNOG" id="ENOG502S63K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024462_1_0_1"/>
    <dbReference type="OMA" id="RHNWSRG"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12874:SF9">
        <property type="entry name" value="F-BOX ONLY PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12874">
        <property type="entry name" value="F-BOX ONLY PROTEIN 48-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25499">
        <property type="entry name" value="Beta-prop_pof12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="87"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="635" mass="70463" checksum="E803B4FF2C39A441" modified="2011-10-19" version="1">MTGLKRVRRPAAADDKDDRPRDNNDADSDSDTNHHPGPSTKRRKLTAFDSDSAPANPSSVSAPVTAGTVSIKHTPYPNSTPPSRTGADLLSPLSDELLLRILSHLSLPHLLAVAPVSRRFYRLASDSQLWKALYYERFVLPRVMRIPGFRDGMSTGKEGAGRLRFHHAGRKMLWVDGRRKEQREDEEEEYRPVDWKRQYKIRYNWARGKCAVEELKLSGELAIDDEEEGRRMLVKVVEGLAVTADRVEGLRAWDLKTRSLIAQIEVVDGNERTAPSAIAVDDSEHHKGILDVALGFTDGSFGVWRLTTKDRKLALRYRHAKSSNGELIAMSFLYPYLLTATRAVLISLYTFEVPITVETGQECHPPRHTVMKGPTEEDTQLPAPYLLTSLDSHTSRPPLALSIRRAAGITIASVAYTFSTRRGWSIGIQDLHIQQVSKGLKSSPEITTTRLAFTTPVEASPYTTSSSSPRTHSSPSSSSATHSESEPGPLTLCYTHPYLLATLPDNTLVLHLCTSTATSLTLSDGIRLWGHTSGISDAEITARGKAVSVSTRGEEMRVWELEGRSLSGSKSVEVRPWQDSSDNGRRALAGEGLNAGDPARDWDERRNWVGFDDEMVIVLKERKGGRQSLMVYDFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0V9</accession>
    <name>G0S0V9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6590 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0011420</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691661.1">
        <property type="nucleotide sequence ID" value="XM_006691598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0V9"/>
    <dbReference type="GeneID" id="18255180"/>
    <dbReference type="KEGG" id="cthr:CTHT_0011420"/>
    <dbReference type="eggNOG" id="ENOG502RQVF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_986960_0_0_1"/>
    <dbReference type="OrthoDB" id="3559580at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046497">
        <property type="entry name" value="DUF6590"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20233">
        <property type="entry name" value="DUF6590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6590" evidence="2">
        <location>
            <begin position="120"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="282" mass="32771" checksum="B50FB9B7A4778624" modified="2011-10-19" version="1">MARRPPSTPAEASGPVCDSASKEDLRSTDRIEQPTSPSQAQEELIFWTWSDERHCWVAEGRELQPTASGSDSTRWEWDDDAKDWVKKFPNGQYIRYADYQKPPTRLNSESRGFEVVKMPKRFFIPGRIFKMMWYEPAPEAQTELSPDSKLDKKCQAFGEEAESRPIARYRWFVVVQRRYDHSICFSVTTYKKGASKTSRSDNVAVLYRVTVDPPLPYDDEKFMRTPIAVIVEDPEHYIAPTARLDCKRVYTVEDGMKVKKIGRVHPRWVPVLEKYYQQAVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0Y9</accession>
    <name>G0S0Y9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0011720</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691691.1">
        <property type="nucleotide sequence ID" value="XM_006691628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0Y9"/>
    <dbReference type="STRING" id="759272.G0S0Y9"/>
    <dbReference type="GeneID" id="18255210"/>
    <dbReference type="KEGG" id="cthr:CTHT_0011720"/>
    <dbReference type="eggNOG" id="KOG0590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_33_1"/>
    <dbReference type="OMA" id="FPPEKKY"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="357"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="120"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="200"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS22699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="721" mass="79607" checksum="4067713EF6AC40AA" modified="2011-10-19" version="1">MAAAAAVQMASLGDPSSGATDANKPSISSSSPYHYPTDLPHPILEEDDETESEVANEPVTPASGRQSQDFQALSAHDVQVDAAHDQLAADSSSATPFPSLQSDLTTTAKPPFVLDTITTPASNVVKTPTPQQSTSTAAVPTPDQEATTPAPPSRRPTFGSSGNFRRTFSALLKRVGNQPDKSATGVSDAVPGLNLSETVPRKGHIRRWSMNRSSATTRSNSPPSPDSPLEMAIKTREQASTPTVPSSEAFFSKKSRALTGFSLRSRPIFNNNANTAPRPQNFQLRRRANSFDYSKEEQPVVESADKAIPMERSPWALPAETGTGVKARRMSLSLPDDFTVDVVELTSEFEYQHKLLGRHGKHLGKGATSKVTLMVSKNGGELYAVKEFRGKSSSETKEEYEKKIKSEYTLAKSLHHPNIVDTIRLCIDHGRWNHVMEYCEDGDLFTLVNKKYLKGEDREKDRLCLFKQLVTGIHYLHSNGIAHRDIKLENLLITKECRLKITDFGVSEVFSGIHPGLREAGGQCGKNMGEVRLCAPAICGSIPYISPEVLAKKEYYDPRGLDVWSAAVVMIHLIFGGPLWHRAEVNPENPKDTYSSLVRGWEKWSKSHADTPDMVITEMDYPHVWVFDEFVKPPALRRVLLQMLNPDPKRRITIANVVNNRWVKNIECCSPETYDEPNAATMIDASKKSCQTRANGKKIYCHNHLPPKEVGMHSLGRMPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0S128</accession>
    <name>G0S128_CHATD</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0012130</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691730.1">
        <property type="nucleotide sequence ID" value="XM_006691667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S128"/>
    <dbReference type="STRING" id="759272.G0S128"/>
    <dbReference type="GeneID" id="18255251"/>
    <dbReference type="KEGG" id="cthr:CTHT_0012130"/>
    <dbReference type="eggNOG" id="ENOG502RPKN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_443502_0_0_1"/>
    <dbReference type="OMA" id="HANVQQF"/>
    <dbReference type="OrthoDB" id="4588713at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="537" mass="58973" checksum="68915DBAD85F068B" modified="2011-10-19" version="1">MSGIQLGNRTTLSSDVSSSGQEPRKQPTYTTVGSIYNPDAATPIQPPTRRARTRRNPFSGRDNSLVNFLDLVDSVLATGSASSNNNWPSQSSSSSTAFNYTPLQQNDARAVSPVRDRGNSTSISVDMPIPNLRSGGLPSPTGFNDTLSPEDALAARINVKGLTNLASYPNPMQKAAQKALARARLANLNRSDSSSTSSLGQSDLINDRFLGIQNSTSVATGLPRPLTAGPPGQRPFKSTTLDAASRCLRVDDQMSPLASIFRPRSSLGVLNNPGPSRPVFEDGNGLTGGDRFGSIVNDERQHHAVSYPSADQSTIRSLSLRSPSEMPGAPSNDLRNKIQDTLPPERAKVYFGNSLPPSYNGRYKPIPDDWHSKYPINERNLTQDPITDRMTKVNRIFYSGAESLVKSMDQIVRDRNYRRLENKVGVIGEERERLRGSHMERVGEDGKLLLPHLTVEQANEMESAELVKPLLNMAFATLLGYKTEAQAGSSNRNPSLHSFKVEEEWIDHSEDGHSSFFSIPPEEQARKRVRRKARRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G0S163</accession>
    <name>G0S163_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="14">5'-3' RNA helicase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0012480</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="16 17 18" key="2">
        <citation type="journal article" date="2023" name="Mol. Cell" volume="83" first="3692" last="3706.e5">
            <title>Sen1 architecture: RNA-DNA hybrid resolution, autoregulation, and insights into SETX inactivation in AOA2.</title>
            <authorList>
                <person name="Appel C.D."/>
                <person name="Bermek O."/>
                <person name="Dandey V.P."/>
                <person name="Wood M."/>
                <person name="Viverette E."/>
                <person name="Williams J.G."/>
                <person name="Bouvette J."/>
                <person name="Riccio A.A."/>
                <person name="Krahn J.M."/>
                <person name="Borgnia M.J."/>
                <person name="Williams R.S."/>
            </authorList>
            <dbReference type="PubMed" id="37832548"/>
            <dbReference type="DOI" id="10.1016/j.molcel.2023.09.024"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (3.01 ANGSTROMS) OF 1087-1878 IN COMPLEX WITH ADP</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691765.1">
        <property type="nucleotide sequence ID" value="XM_006691702.1"/>
    </dbReference>
    <dbReference type="PDB" id="8FTH">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.17 A"/>
        <property type="chains" value="A=1-903, A=1090-1858"/>
    </dbReference>
    <dbReference type="PDB" id="8FTK">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.56 A"/>
        <property type="chains" value="A=1-1993"/>
    </dbReference>
    <dbReference type="PDB" id="8FTM">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.01 A"/>
        <property type="chains" value="A/B=1087-1878"/>
    </dbReference>
    <dbReference type="EMDB" id="EMD-29426"/>
    <dbReference type="EMDB" id="EMD-29439"/>
    <dbReference type="SMR" id="G0S163"/>
    <dbReference type="STRING" id="759272.G0S163"/>
    <dbReference type="GeneID" id="18255286"/>
    <dbReference type="KEGG" id="cthr:CTHT_0012480"/>
    <dbReference type="eggNOG" id="KOG1801">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000459_2_0_1"/>
    <dbReference type="OMA" id="PWHQSEL"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001147">
        <property type="term" value="F:transcription termination site sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18042">
        <property type="entry name" value="DEXXQc_SETX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001152">
        <property type="entry name" value="tRNA-splicing endonuclease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024481">
        <property type="entry name" value="Helicase_Sen1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056474">
        <property type="entry name" value="SEN1_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF495">
        <property type="entry name" value="HELICASE SENATAXIN ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23576">
        <property type="entry name" value="SEN1_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12726">
        <property type="entry name" value="SEN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="16 17 18" id="KW-0002">3D-structure</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 16 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase Sen1 N-terminal" evidence="10">
        <location>
            <begin position="90"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase SEN1 beta-barrel" evidence="13">
        <location>
            <begin position="1169"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="11">
        <location>
            <begin position="1317"/>
            <end position="1609"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="12">
        <location>
            <begin position="1616"/>
            <end position="1812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1039"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1868"/>
            <end position="1942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1972"/>
            <end position="1993"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="976"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1044"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1868"/>
            <end position="1880"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="1322"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="1322"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="1343"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="1345"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="1345"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="1346"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="1346"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="1347"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="1347"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="1348"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="1348"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="1405"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="1639"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="1639"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="1769"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS22773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="8FTH"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PDB" id="8FTK"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PDB" id="8FTM"/>
        </source>
    </evidence>
    <sequence length="1993" mass="223495" checksum="21BEA4B5A7DBF4BA" modified="2011-10-19" version="1">MENNDLYQAAIGWYRAFEDCPPELHLCCPKVDDDDYATYDEPDVVDDSGVPVEEKKRRISAYEERFQNVYNLSILLGLGKEVAGPWLDEWTRAVDSLLKKCDTCVRNWHRNRDPYLKALHLSPEQVTYLQSKLDEFDRQRITEGLQRAKAILEQYGPMSTVKLVDHDMSAVLALYEALCSLPYLARPEHQPLFDFVFENTQRKKPLRMQGGIIPSMTLFLFDESPVRRRFAETAWENRQPGSITAQEWDWAISGRLADQIVSLSFNRLQTLPPGQKILRFWSGFLFILHALSEKQIINSLRAMEVSPSIYFLALEHLGTNSDEALAMVLRALQELMEKSSKAFWQALEQVPPNQLVEEIFKSAAFRPLLNKSLRPELLVTEGDSQVPALAAWMRALVRSLPSTSWSDLCETSLRHLFETFRSDQAVDQSGRATCTLAGLVTLQQCLDGFLQQDSIDTGTGLIMVNQLLNRVVNYSEIIIRAASLKPGDIYNVGISKAAMAIIHSALALDAKATEVEWAALIAEKPVQDAVNRDSGALWETFLEMLWAGQLGHFELAKAMLMATLRLRSIEQFIPKRKEQLKRELDKFNKRYQQQTTAIGKMLNRLTDFEPEVLDKLCSDPRGQTIHPIVSSLIHGEDAIREAGFQLLKAITSESQPSDAVGRMLEVYFTPFLNAFSQAVDKLTATKDANSPWSHMIPILKCSDFVLTGLCDPSSGQLRRKVLTTEEHAAVKRWWECVWQAVDHSFRMMRIWHIKIDKKVMEDFCRDVMELGNKLLAQDGVMASSLAQESGEDAISKAMREVLDPPRKCSYSLADMLQLRDKYLVMGIIETIKKLLSRLQENEMNLPQRTRGHLDSMLKKTKQRDGRMDYLTKTNLTDVQRIELLKALGEDAVIEEQFMGTKPGDREAKEKERALKQSKLDFSKAGISYSGDINEHLAQITPNFEKYHKSSLLETLKKEEPAKPKAPAKLSQQAILANQQQIKEARARERAEKARRDAEAIAKAKALRAGKTIPGEGSGLQSIAGVRGKDHAPVVKDEIMVGSSSEDEGDDDDDDDVINRAKTKSKKIWDEAERRRLELEAEKLRGPVKKMKILRSAKDMRARLIPPMDVLHQAILEWDIFHEGNDPPNGYRCGNVSDTYPDPYSYKQTFFPLLINEAWRSFVTAKDETTSKPFGIKVLSRMTVDKFMEVTAAVPAQISKDRGLTEGDIVIISKGEDPLNQPQELHCLSRIWKTTYKKDTVEVVYRLNAKGNQILPALTPGSEFQVVKITNMTTIEREYAALESLQYYDLMDEILKAQPSPMLTFGDEAIKAVMDNYQLNPGQARAILNAKENDGFTLIQGPPGTGKTKTIVAMVGCLLTGVLKSSNTGAVQISRPGAGPTNGTAPSKKLLVCAPSNAAVDELVLRLKAGVKTMNGTFHKIEVLRLGRSDVINAAVKDVTLDELVKARMDAELSKNSSPSERDQLHKEAGEIKAKLAEIRPQLDAARLSDDRASAMKLQREFDELKRRQAHIGAKIDADKASGNTYARETEIKRRQIQQEILDKAQVLCATLSGSGHEMFKNLNVEFETVIIDEAAQCVELSALIPLKYGCNKCILVGDPKQLPPTVLSQSAAKYGYDQSLFVRMQKNHPKDVHLLDMQYRMHPEISRFPSKEFYEGLLQDGADMARLRLQPWHQSVLLGPYRFFDVKGSQERGPKNQSLVNEEEVKVAMQLYMRFRSDYRDIDLTGKIGIITPYKAQLQRLRQKFVERYGESITEQIEFNTTDAFQGRECEIIIFSCVRASPTGGIGFMTDIRRMNVGLTRARSSLWILGDSRALVQGEFWAKLIEDAKQRDRYTNGNIMALLSQPGPRVSLESLAKQYSVPVAPVARSKEDVEMHDTPRTSESIPPAMPYRGSGIGGLNERGEATTPTTRGGELPIIQSTDGSAGKKRPRDANEENRPAFDPAKASSAFWFTQTTGIGIGIDRSFCDGSFGAGSSNPSASSATATPSSSGTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1E1</accession>
    <name>G0S1E1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0013270</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691843.1">
        <property type="nucleotide sequence ID" value="XM_006691780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1E1"/>
    <dbReference type="STRING" id="759272.G0S1E1"/>
    <dbReference type="GeneID" id="18255365"/>
    <dbReference type="KEGG" id="cthr:CTHT_0013270"/>
    <dbReference type="eggNOG" id="KOG0417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_13_2_1"/>
    <dbReference type="OMA" id="AEPHEDN"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23813">
        <property type="entry name" value="UBCc_UBE2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000020">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="8">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS22851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="153" mass="17110" checksum="0CCB867FAE2DFDC6" modified="2011-10-19" version="1">MAAGLPKRIVKETERLMAEPVPGISAVPHEDNLRYFDVEIHGPSQSPYEGGVFKLELFLPEDYPMAPPKIRFLTKIFHPNVDKLGRICLDVLKNNWSPALQIRTILLSIQALLGAPNPDDPLAADVAKSWKEDEQAAIATAREWTLKYAVPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1Q2</accession>
    <name>G0S1Q2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative chitin synthase regulatory factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0014410</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691954.1">
        <property type="nucleotide sequence ID" value="XM_006691891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1Q2"/>
    <dbReference type="STRING" id="759272.G0S1Q2"/>
    <dbReference type="GeneID" id="18255479"/>
    <dbReference type="KEGG" id="cthr:CTHT_0014410"/>
    <dbReference type="eggNOG" id="KOG1550">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_126_0_1"/>
    <dbReference type="OMA" id="RLSIVWY"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF3">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1128"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="214"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="345"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="382"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="401"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="489"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="521"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="545"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="561"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="600"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="620"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="757"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1159" mass="124474" checksum="B07FB20250575618" modified="2011-10-19" version="1">MAYNGQYGGGPGPQRPPPQRSYTPGPGGHPRQYSAPPPPQQQYNQYQDGGYNDYGYDNYGNGYDQGYGGQYDDPGYGRGGPPIRNYPPQDYYDQGPNAPGAAPGRGGPQMPPPGGRGGPMRGPPGPGPGRGGPYPPRGGAYGPGPGGPPGPPGPGGRGYPPPSRDGRLGPSERPMNSQPNGELIRCTLSPPLTVREKRAYADMLVAGRPLMGDSGSSNVGNSGFNGPFPTFPGAQRRTDYEEERYIVSQIEGMDISGQRPGPRSPEGPPPQHGPMRPPPSGFGGSGPGPMGPSRGPSQAYRSPSDYPDQRRGPPPGPGYGPPAAAGLQDEGFAPPSRSVTMPMRDQMDMRAGDPVHRDSAPYNGPVGRGMPPRPSTSQGMRQPPPRIYPPNNGPPPHSNHEQGPGPEPGYQGHGRPPSVDDFYDYYGDNVNNEYPARNPTSAASELPNFDSLASQKSRNSLDHHMQAGGATPQEQAQRGPGRYPEISRAKSQPNLRNSQTAVFEMAGDIPPLPAQNPAARPSGQGPPSSQQQPGPQEHGPEQSDPNHPSSQPSDYHQHGTQSPGPQQPDYQQPGPQQAGPPPSDFQQGGPEYDQYSGPQGPAPQPDPPNGPQLHRAPTAQFGSSHSQPWHQGLPNGPQLHRSATTQFDHQLSGAQYYGPQQGPPNGPLLQRSATSQFGPGPGQGLPQGPAPYRPGLQRAATQAGPHLDVLPSHPPPVRPGHMPGSVVNLGDRPPPVRNYGGAPGYGNAAPSQSPEGQDQASAAQQQPPIGQPRKKKEAEPPVTAEELEQLRAIVKNDPNDQTSALRLAKKLVEAADVLVPNLPDPKARARSRERYLVDAHKILKKLEKANNPEAMFFLADCLGRAVFGNEPDPAHAFTLYQSAAKLGHAAAAYRTAVCCEIGNDEGGGTRKDPLKAMQWYKRAAALGDTPAMYKVGMILLKGLLGQQRNPREAISWLKRAAERADEENPHALHELALLYESAEPNDVIIRDEAYAFQLFKQAAELGYKFSQFRLGCAYEYGLLGCPIDPRLSIMWYSRAAMQEEHQSELALSGWYLTGSEGVLQQSDTEAYLWARKAAMAGLAKAEYAMGYFTEVGIGVPPNLEDAKRWYWRAAAQDFPKARERLEELKRAGKNGGQRPRERISRSRMTKQQDGDCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1U4</accession>
    <name>G0S1U4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Short chain dehydrogenase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0014840</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS23004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691996.1">
        <property type="nucleotide sequence ID" value="XM_006691933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1U4"/>
    <dbReference type="STRING" id="759272.G0S1U4"/>
    <dbReference type="GeneID" id="18255522"/>
    <dbReference type="KEGG" id="cthr:CTHT_0014840"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="OMA" id="MKETSWP"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF127">
        <property type="entry name" value="3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS23004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="27369" checksum="E24BEDA60C3ED9DC" modified="2011-10-19" version="1">MTSPQGKTVIITGAAGGLGKAIAEAFLATGANIVVCDVHPQRLASVNEEWTKVYPDKFLTQQVDVTDEAAVNALIEAAVAKFGRIDILINNAGVMDDFSPAGACSKALWDRVLNINLNGPFLATKAAIAQFEKQDPTGGIIINIGSNASYHGFSAGAAYTVSKAGVMALTKNTAGFYGDKKIYCIALLLGGMNTNITDAFAQGINMEMLKKVQAAASPFSPEKQVPIESVAKYCVFLTDKDIAPSANGSCIVFNKNWPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1W5</accession>
    <name>G0S1W5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aspartic-type endopeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0015070</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A22B family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS23025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692017.1">
        <property type="nucleotide sequence ID" value="XM_006691954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1W5"/>
    <dbReference type="STRING" id="759272.G0S1W5"/>
    <dbReference type="GeneID" id="18255545"/>
    <dbReference type="KEGG" id="cthr:CTHT_0015070"/>
    <dbReference type="eggNOG" id="KOG2443">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023799_1_1_1"/>
    <dbReference type="OMA" id="TFWTGTL"/>
    <dbReference type="OrthoDB" id="29661at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098554">
        <property type="term" value="C:cytoplasmic side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007369">
        <property type="entry name" value="Peptidase_A22B_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174:SF23">
        <property type="entry name" value="MINOR HISTOCOMPATIBILITY ANTIGEN H13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04258">
        <property type="entry name" value="Peptidase_A22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="248"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="456"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="509"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="515"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS23025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="566" mass="62572" checksum="E794B736F621BF84" modified="2011-10-19" version="1">MPSTVDTSGVAAVPSQPTPTVELTATDPGSPLGVFAFVKVLEPHLLFLMLSSLTLLWIGAHSALRRPPSAAPTESTKQEKKKEKPRENLEFSDAILFPLCLGVALAGMYYVIKVLQYADIVNSILRVYMSVMSIAGTGTLIGDALDIYTSLIFPDMWADQTGRLYHIDQNQRRQLVVEKETGKKVPTPDKTNPLPGKLSEWRFSPKLVDILWGVRGILNQEWSLRFATYGKTRVKIGVRLNDIVKVSIATALAITYHFAKGIFVSNLLAIALCYSSFSLISPTSFAIGTLVLGGLFVYDIVMVFYTPLMITVASKVDAPIKLVFKGAKSGSILGLGDIVVPGFIICLALRFDQYQYYKKQIKLEPVELKTILPDGTVSTTLTHRRVKVPYVSPRNQWGNRYWTTPPGRLSPIPQAYEPISATAFPKPYFYASLIGYTFGMVSTLLVMVVFNHAQPALLYLVPGVTGSLWLTGLIRGELKDMWEYTEDGSLDVKDVVVEVDGKGNVIQQIGEEEVEKMKEDDEKGQKDKNGADNSTEGSGGKAKKDEEWYELFTFTITAPRMRLSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0S279</accession>
    <name>G0S279_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RAD50-interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0016280</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692131.1">
        <property type="nucleotide sequence ID" value="XM_006692068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S279"/>
    <dbReference type="STRING" id="759272.G0S279"/>
    <dbReference type="GeneID" id="18255666"/>
    <dbReference type="KEGG" id="cthr:CTHT_0016280"/>
    <dbReference type="eggNOG" id="KOG2218">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015529_1_0_1"/>
    <dbReference type="OMA" id="GMTWEVL"/>
    <dbReference type="OrthoDB" id="2189254at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070939">
        <property type="term" value="C:Dsl1/NZR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060628">
        <property type="term" value="P:regulation of ER to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.670">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042044">
        <property type="entry name" value="EXOC6PINT-1/Sec15/Tip20_C_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007528">
        <property type="entry name" value="RINT1_Tip20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13520:SF0">
        <property type="entry name" value="RAD50-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13520">
        <property type="entry name" value="RAD50-INTERACTING PROTEIN 1 RINT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04437">
        <property type="entry name" value="RINT1_TIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51386">
        <property type="entry name" value="RINT1_TIP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="793" mass="89185" checksum="23D990855D90A669" modified="2011-10-19" version="1">MMEADTRVEDFLDDKLQTPADLAHIDTLLSAVELQRSQLQSQLDDATRALDEARRVAADRSAALAAQIAEFDKLQKGIDVRLRIVSASDAPDAAVRRLERPLKQLESVELAYKYLMLLQDVEGLREEARKCLPGDPRKALEPYGRLKELALRLKKLQEEADGAAVFLVSHVETAVDRLWEEMKGIMRTELERVLEKRKWPAQVSPESEIDEEWLQCFEKLLDLQLPEILHAASTPKPEVVTLLAMDVMTDIFVKEFRFHFLSDKPTSAPQVIGQHCFPWVLNLLEKWEDFFRDNFSPLLAAKFADTPAARKMVYMDPVCAFISSLLPVIREKVTRTLEQTQGDTAFLSSLLSQLMTFDDQLRSSYAYDGGLDSEEWGGLTAEVLATHFRTWLEAEKIYALDRYHEIMATQDCRQIDYDFAGPGKTKPTFGAVRVTDLLRSITQQYCRVRKFGHKLRFLIDIQLTILDEYHDALRGSLEAYLSLTSTVGRAFGVSKEQLAALEGTGALEALCKVYGSADHIVNTLREWSNDEFFVALWQELQDRAKAASKNNSSSGAGHKKRESLSVGISYDQIKDRTSAAVGSDDEEGVLFDETIAAYSQRRKRAEEFLADALVDSHKKAFKAYLHRPNWSTVAEDADLAITPELDEPLRILQRDLAFLRRALGTAPLRRIWRSALDRLNSMLWTDVLMSARFTSAGAAQFARDINAIVSLVERYLPDVGSGSLAALGEALQLLTLPAKLPEGQEAGLTLKSATDRVFTDNAQAKKVLEEMGLEILSPANARQILQRRVENAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2F8</accession>
    <name>G0S2F8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0017080</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692210.1">
        <property type="nucleotide sequence ID" value="XM_006692147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2F8"/>
    <dbReference type="GeneID" id="18255746"/>
    <dbReference type="KEGG" id="cthr:CTHT_0017080"/>
    <dbReference type="HOGENOM" id="CLU_1019423_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="273" mass="27631" checksum="C464F6C67A0068E6" modified="2011-10-19" version="1">MTSGQPVDQSIKQQIAEQKRMWTQIIADQNQRVEYFVRTLGNKHEASVRVIEREKTLGTCMGAAPWPLETIYATRSPNGKVFVDGKLVGTIPDPIPGFISTSSGGRDATPGSGSYGGGSYDYTPGIQSGQLSNIGASYLKTGMGGEYGGAGTPGGYSNSQRGSSNNQGGRGGRLVPDKAVVPAATNKVTATKATKKPGASNDLAAGLANLKLAPSHSPGSAKAKPLSPVANGASGSAALAKKIPPEASKGAASGSAKVSAAGSSASSSKKIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2W4</accession>
    <name>G0S2W4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0018720</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692366.1">
        <property type="nucleotide sequence ID" value="XM_006692303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2W4"/>
    <dbReference type="SMR" id="G0S2W4"/>
    <dbReference type="STRING" id="759272.G0S2W4"/>
    <dbReference type="GeneID" id="18255910"/>
    <dbReference type="KEGG" id="cthr:CTHT_0018720"/>
    <dbReference type="eggNOG" id="ENOG502RM4B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035914_0_1_1"/>
    <dbReference type="OMA" id="ADMYISP"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF125">
        <property type="entry name" value="N-ACETYL-6-HYDROXYTRYPTOPHAN OXIDASE IVOB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409249" description="Tyrosinase copper-binding domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS22347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="382" mass="42337" checksum="B9F0F2161D01E1A9" modified="2011-10-19" version="1">MKFLSFAIASLAAASGASAINLPSFEQFAIDSGLALAGLNGIALVNSAFHYKGGCNPLNVKIRREWRTLTKSQRRQYIAAVKCVLKKPSILPNGWAPGSKSLFDDFTWVHMNQTLFIHNTGNFLIWHRYFIQLFEDELQKCGYNGGLPYWEWGYDVKNPRDSPVFDGSDTSLGGDGEYIPNKPNVEITPIGSPGPIILKPGTGGGCVKTGPFAGMITHLGPSTEADPNQDNPRCLKRDLNPDCAQRFTSFRNTTELILNSPNIEIFRTHLEGDPRYTPYSLGVHGGGHFTIAGDPGSDAFISPGDPAFYLHHSQVDRVYWIWQMLDFQNRQTVFGTQAIMDLWPAPNTTVEDVIDIRPVASKTYKIKELMNTVGGPLCYIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G0S331</accession>
    <name>G0S331_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0019470</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692433.1">
        <property type="nucleotide sequence ID" value="XM_006692370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S331"/>
    <dbReference type="GeneID" id="18255985"/>
    <dbReference type="KEGG" id="cthr:CTHT_0019470"/>
    <dbReference type="eggNOG" id="ENOG502RJD0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1304732_0_0_1"/>
    <dbReference type="OrthoDB" id="5292349at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="211" mass="22854" checksum="8E1FDD410C3DC169" modified="2011-10-19" version="1">MGRPPGVPGRKQLTAEDIFRCQVLYRDARMGPTEIQRVTGYTLHQVKYALKKKTPTVGIRTGRPRKVAPTSSQNTEREESAQGERGAEAGQQDHILLDQPPTSNADVSQQPQPQQPSLSQAPGWSQGQVPVQSLPPSDQQSLSQPPPAPTVLTQQPYGRIQSQYLQSVPSDQQPPQAALCLGNDVTHPVAGQPPPPPSTLAPMTQTQVPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0S340</accession>
    <name>G0S340_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA replication complex GINS protein PSF3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0019560</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GINS3/PSF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692442.1">
        <property type="nucleotide sequence ID" value="XM_006692379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S340"/>
    <dbReference type="STRING" id="759272.G0S340"/>
    <dbReference type="GeneID" id="18255994"/>
    <dbReference type="KEGG" id="cthr:CTHT_0019560"/>
    <dbReference type="eggNOG" id="KOG1106">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081646_0_1_1"/>
    <dbReference type="OMA" id="IYKEGWR"/>
    <dbReference type="OrthoDB" id="10251744at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11713">
        <property type="entry name" value="GINS_A_psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21693">
        <property type="entry name" value="GINS_B_Psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010492">
        <property type="entry name" value="GINS_Psf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038437">
        <property type="entry name" value="GINS_Psf3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055221">
        <property type="entry name" value="PSF3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22466">
        <property type="entry name" value="PSF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein PSF3 N-terminal" evidence="8">
        <location>
            <begin position="4"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="GINS subunit" evidence="7">
        <location>
            <begin position="76"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS22423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="196" mass="21628" checksum="9CE110F9C9E69183" modified="2011-10-19" version="1">MSYYDIDAILTDAEKIPCTFQLDIPDLGYLDNAPDRPLKAGTKVNLPFWLAEMLAIANAGDVDGKQYITFDLPPALSNDVVQALKADPRSVPLRDQSAHFYALATRMMELSDEPELASVLRKTFVTRASEIALHARKVGGVGHSKGKGSEEGSNLGIGGAGEEFLRGLDEWERKLFRKAHDGAKATKEWMETIKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>G0S356</accession>
    <name>G0S356_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0019740</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692458.1">
        <property type="nucleotide sequence ID" value="XM_006692395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S356"/>
    <dbReference type="STRING" id="759272.G0S356"/>
    <dbReference type="GeneID" id="18256012"/>
    <dbReference type="KEGG" id="cthr:CTHT_0019740"/>
    <dbReference type="eggNOG" id="KOG1290">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1128945_0_0_1"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS22439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="246" mass="27299" checksum="0ADF89E3673B6BC9" modified="2011-10-19" version="1">MNCSVPVLANLQAFDPILLPETAYDGHNTEPLQLYGPGKLHPTHLGDAIGPAEAPNRFRIVAKLDHSNHSTSWLARDGLNDTWRRVDFLTGSPDIGRNKAESMTLSIQTYRAAPGADIARADAKGVPLEMFTIAGPNGKHSVVVFPLNGDFNCFRWGIEPDLDEVEMNETWFVAKCTKLRQTQGCAGPVSIHEITEQEILQILGRPNVIMVTNTLFNDFVVDSDIRRNQVPVYLVERPERITIDKG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2017-03-15" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3J5</accession>
    <name>RIO1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName>Serine/threonine-protein kinase RIO1</fullName>
            <ecNumber>2.7.11.1</ecNumber>
            <ecNumber evidence="6">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ORF">CTHT_0021480</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2014" name="Nucleic Acids Res." volume="42" first="8635" last="8647">
            <title>Dominant Rio1 kinase/ATPase catalytic mutant induces trapping of late pre-40S biogenesis factors in 80S-like ribosomes.</title>
            <authorList>
                <person name="Ferreira-Cerca S."/>
                <person name="Kiburu I."/>
                <person name="Thomson E."/>
                <person name="LaRonde N."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="24948609"/>
            <dbReference type="DOI" id="10.1093/nar/gku542"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>PHOSPHORYLATION</scope>
        <scope>MUTAGENESIS OF ASP-281 AND ASP-298</scope>
    </reference>
    <comment type="function">
        <text evidence="2 6">Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit (By similarity). In vitro, has strong ATPase activity and only low protein kinase activity (PubMed:24948609).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="6">Autophosphorylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1"/>
    <dbReference type="EC" id="3.6.1.-" evidence="6"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692618.1">
        <property type="nucleotide sequence ID" value="XM_006692555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3J5"/>
    <dbReference type="SMR" id="G0S3J5"/>
    <dbReference type="STRING" id="759272.G0S3J5"/>
    <dbReference type="GeneID" id="18256186"/>
    <dbReference type="KEGG" id="cthr:CTHT_0021480"/>
    <dbReference type="eggNOG" id="KOG2270">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018693_4_0_1"/>
    <dbReference type="OMA" id="HPMSLDF"/>
    <dbReference type="OrthoDB" id="205248at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000148">
        <property type="entry name" value="Serine/threonine-protein kinase RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051272">
        <property type="entry name" value="RIO-type_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017407">
        <property type="entry name" value="Ser/Thr_kinase_Rio1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45723">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038147">
        <property type="entry name" value="Ser/Thr_PK_RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000439042" description="Serine/threonine-protein kinase RIO1">
        <location>
            <begin position="1"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase">
        <location>
            <begin position="122"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="418"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Association with (pre-)40S ribosomal particle" evidence="6">
        <location>
            <begin position="440"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="439"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="497"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="8">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="mutagenesis site" description="Decreases ATPase activity." evidence="6">
        <original>D</original>
        <variation>A</variation>
        <location>
            <position position="281"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Decreases ATPase activity." evidence="6">
        <original>D</original>
        <variation>A</variation>
        <location>
            <position position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="G0S5R3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q12196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="Q9BRS2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR038147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="24948609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <evidence type="ECO:0000305" key="8">
        <source>
            <dbReference type="PubMed" id="24948609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="519" mass="59279" checksum="D85E503B9FE0AF3F" modified="2011-10-19" version="1">MTPAPEPQDPPTIHEPVATEQTDDISDWDVESDYEDGYGAPSKSQAQGGASAADRPKINAHARIDDQMTDLARHASKIRLDNLTMQQIFRDKDRTDNATSDQVLDNHTRMIILNMLNRNIISEIYGTISTGKEANVYNAVAYDNNGERIERAVKVYKTIILGFKDRERYLAGEQRFKTIVDKALSAPRKMIKLWAEKEFRNLKRLHTAGIPCPEPIYLKYNVMVMGFLGDHTNGYAFPRLHDTKITGETLEETEAEWRRLYINLLSMMRRMYQVCGLVHGDLSEYNILYNEGVLYIIDVSQSVEHDHIEATNFLRMDIRNVNDFFARRGVDTLSDRTVYHFITDSTGAVDENGMRKAIDNLYATRPPLAESEEARAEQEIDNQVFRNQFIPTTLEEVYNLEVELGKKVDTRLYQHMLADSKVPESTGGEHKSGEGGESGSEDEEGDEGESGEVESGDEEREEGEGDRFEKKRPRGKKHLDKAEKHAHKMAVKEAKREKRKEKMPKHVKKKLVAANKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3J9</accession>
    <name>G0S3J9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA pseudouridine synthase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">tRNA pseudouridylate synthase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">tRNA-uridine isomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CTHT_0021520</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Formation of pseudouridine at positions 27 and 28 in the anticodon stem and loop of transfer RNAs; at positions 34 and 36 of intron-containing precursor tRNA(Ile) and at position 35 in the intron-containing tRNA(Tyr). Catalyzes pseudouridylation at position 44 in U2 snRNA. Also catalyzes pseudouridylation of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a uridine in tRNA = a pseudouridine in tRNA</text>
            <dbReference type="Rhea" id="RHEA:54572"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13934"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in snRNA = pseudouridine in snRNA</text>
            <dbReference type="Rhea" id="RHEA:51124"/>
            <dbReference type="Rhea" id="RHEA-COMP:12891"/>
            <dbReference type="Rhea" id="RHEA-COMP:12892"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692622.1">
        <property type="nucleotide sequence ID" value="XM_006692559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3J9"/>
    <dbReference type="STRING" id="759272.G0S3J9"/>
    <dbReference type="GeneID" id="18256190"/>
    <dbReference type="KEGG" id="cthr:CTHT_0021520"/>
    <dbReference type="eggNOG" id="KOG2553">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021971_1_0_1"/>
    <dbReference type="OMA" id="NKAFDCR"/>
    <dbReference type="OrthoDB" id="10256309at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02568">
        <property type="entry name" value="PseudoU_synth_PUS1_PUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041708">
        <property type="entry name" value="PUS1/PUS2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF4">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="17">
        <location>
            <begin position="450"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="341"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="629"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="356"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="402"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="629"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="14">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGS20326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="658" mass="74030" checksum="41CC3CD3DD1B1767" modified="2011-10-19" version="1">MADNENIPQVAPPSGPTPEPKPAAVAEAAQSTENTPKENNHDSNRSNTTPSSSKPAGGSTRGDDKPHKRKHTGFGAAKGEVPDKREQVAQNREAKRRRIIEGENGGHSYMSITFPPEEIAAEQRRPKRKVAVLIGYAGTGYHGIQINHKERTIEGDLFAAFVKAGAISKVNADDPKKSSLVRCARTDKGVHAAGNVLSLKLIVEDPDIVEKINSHLPDQIRVWGIQRTSNGFSCYQACDSRWYEYLMPSYSLLPPHPKSFLGKKIIESAKEKGVYDEYMSRLDDVKDFWEEVEKNDIKPILDRLDPSIKPEVLRKLYASVDQVLTDETEPTQDNEGMAQDVEMKDASEQSTAAQDGKPEAAKADSDTKMEGTSASDKLKDTKMEDAKAESKSKQDSAFTVQKSKDSKSKSDKDKELTPVELALREIKAAYVAAKRRYRVTPVRIQRLQEALNQYLGTRNFHNYTVMKAFKDASAKRHIKSFQVNPNPIQIRDTEWLSLKVHGQSFMMHQIRKMVAMAVMVVRCGAPLDIINQSYGPRRISIPKAPGLGLMLERPMFTEYNKKAVTIGREPIDFAKYEDKIKAFKDEHIYRRMFELEEKENSFHLFFNQVDNYRTDYFLWVTAGGLEASHERSERTERVPKALQAELGDDADGVEERGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3M0</accession>
    <name>G0S3M0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL14m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0021740</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692643.1">
        <property type="nucleotide sequence ID" value="XM_006692580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3M0"/>
    <dbReference type="STRING" id="759272.G0S3M0"/>
    <dbReference type="GeneID" id="18256212"/>
    <dbReference type="KEGG" id="cthr:CTHT_0021740"/>
    <dbReference type="eggNOG" id="KOG0901">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095071_2_0_1"/>
    <dbReference type="OMA" id="IVCVVQK"/>
    <dbReference type="OrthoDB" id="274765at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.150.20:FF:000005">
        <property type="entry name" value="50S ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_uL14_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_uL14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS20347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="130" mass="14006" checksum="AA6345E8E80B0D43" modified="2011-10-19" version="1">MIQLKTMLNCIDNSGAALVECAMIVGQKRHASIGDRIVVVVQKQRGAGAEGMAGTSGAKVKRGDIRHAVVVRTRQPVQRRDGSVIRFDDNACVLINKSGDPIGTRINGVVGQELKKKKWSKILSMAPMQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3V2</accession>
    <name>G0S3V2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0038990</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS22014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694310.1">
        <property type="nucleotide sequence ID" value="XM_006694247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3V2"/>
    <dbReference type="STRING" id="759272.G0S3V2"/>
    <dbReference type="GeneID" id="18257937"/>
    <dbReference type="KEGG" id="cthr:CTHT_0038990"/>
    <dbReference type="eggNOG" id="ENOG502T4AS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032743_0_0_1"/>
    <dbReference type="OMA" id="GVHLHEG"/>
    <dbReference type="OrthoDB" id="5224238at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="444"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="543" mass="58411" checksum="875A0ED2572F4CCF" modified="2011-10-19" version="1">MDKLPVELIRLIYDHCDVPSVRALRLVSPTFADVGYDYLVDLHFTACEWRDDVDRLRCIANHPRLRHSIRSITFAVSKDDPSDALRARLASQPSSPQQLRRSSDEQLAARFRQGANLSDDHHSSDAETDEDDEPWPSIRLTPFHTKTAALKSALAKLPNLRHVAITLSSAPHEPILFRKLGCAGARPFCRRPRDQIRASLSAVAAALCSVSQSLTSLSINPLPLEILRHQEERKAWLDLAESKTVSSLTRLALVIDHAPTQLPPRGRLCAVASLGHLIQRCGSSGTLTHLTLAFRAADAPRAKFNLDFSELFPLSSPTTADSTSSAFSFPSLTSLHIEGASCSEPDLRSFLLRHAPTLEKVRLGGRGCVRSPAERSVGGVHLHEGTFRGLFSALQGRLPRLRRFTMEGDMEAGRLLRAGAGAREVFYFSPGANNESEDEEEEGIPASGEGLGSTISSTSSSRRQSASSTASGTSSASTGTSEASSTSSAIASVASSSGLTSRPASPCIEAVDSSVVERFLIHGGEYPLVANRPAAVPPQAGAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G0S407</accession>
    <name>G0S407_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0022110</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692679.1">
        <property type="nucleotide sequence ID" value="XM_006692616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S407"/>
    <dbReference type="GeneID" id="18256249"/>
    <dbReference type="KEGG" id="cthr:CTHT_0022110"/>
    <dbReference type="eggNOG" id="ENOG502S3JP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_894824_0_0_1"/>
    <dbReference type="OrthoDB" id="2107166at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="340" mass="36804" checksum="EDAAB14C8174858C" modified="2011-10-19" version="1">MGRWSYLDSDEERLPVGMVRVGYDADTQTYTYRDLNGTYWTGAPGARYGELHRIPSRKTRPSQSNRTSPVSNTNIWVDTARDRDDRSPTNKDSTIATTNALSTDYTYDYTEKWTQSLSPVSPSHSPQVPTMTQTPSTLSPTVAATPAPPPHSGADYPLPASPTTHRPLFKAPSPELHHPRPIKRTGSTLARLARFLSTASNASSSPGSRTGSLRRRATVAEKCISRSGNATTSPIPTPNLAAAVSEKPPQELHTPAYGYGHAQGYGHGYFDTKQGLARSQTLRVPLQLKETGPGPGPGPGPETGTGNVSPAVTRATTFDEILAGIEKDKLEAQKKEKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>G0S476</accession>
    <name>G0S476_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0030990</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693546.1">
        <property type="nucleotide sequence ID" value="XM_006693483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S476"/>
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    <dbReference type="HOGENOM" id="CLU_1309977_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="210" mass="22807" checksum="745DEC42FB54C5F6" modified="2011-10-19" version="1">MRPFSPALTVILLPWQSPKTATQRSSRLWVGRSLAMVRRGASASSISIQGDGPGRWAMLRQVRRFAGSQASVLRRDGSRPVEARSNMDRVGLCHGRLGIAAPQRLGSTLHGTRLHEADRAMSPPAGETTARSSNGLWRARGALVERGTHSNRSMETGNTATSPNGAWRWALRAAGSHCGTSWRRARKGEESTDDEVEARMDGAEPRDGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4G5</accession>
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        <recommendedName>
            <fullName evidence="8">Large ribosomal subunit protein mL67</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0022730</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL67 family.</text>
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        <property type="protein sequence ID" value="EGS20443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502S5F1">
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    </dbReference>
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    <dbReference type="OMA" id="GQIMMKK"/>
    <dbReference type="OrthoDB" id="5333655at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:DNA strand exchange activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024629">
        <property type="entry name" value="Ribosomal_mL67"/>
    </dbReference>
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        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28184">
        <property type="entry name" value="MITOCHONDRIAL HOMOLOGOUS RECOMBINATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12829">
        <property type="entry name" value="Mhr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408898" description="Large ribosomal subunit protein mL67" evidence="10">
        <location>
            <begin position="22"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="210"/>
            <end position="245"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00035185"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS20443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="311" mass="34604" checksum="B33F207E51E96C94" modified="2011-10-19" version="1">MSHSMRARPTLFQMFGGLVRAAQTGGCGCGGRVEATAAAAAVRGVRFMSGAVEEATEEQSRAPQRHPRGQQPAGHGERFWVWHHIATNMVVYSLTPVLDINKAKRQFAFTGKKLVPAKIRKDYWRPLAMVELGAGKGEVGRSVYQKLRELKKRHELEWEDERLLNLPKKLRGIELNDMRGNFVADLAYVCAGHGKGNLVVVKEEEDSKVKKKKSKNSKVVQANQAGENKAIEQEQQQQEEEKANKAPKLHTVTVYWANEQDKYYAESWTDNVTHIVGIPDYLPGPKTKTMATLNLSAEADARSQAEAVATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4I1</accession>
    <name>G0S4I1_CHATD</name>
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        <submittedName>
            <fullName evidence="7">Putative sister chromatid cohesion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0022910</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006692692.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S4I1"/>
    <dbReference type="GeneID" id="18256329"/>
    <dbReference type="KEGG" id="cthr:CTHT_0022910"/>
    <dbReference type="eggNOG" id="KOG1525">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002562_0_0_1"/>
    <dbReference type="OMA" id="YPPAYNM"/>
    <dbReference type="OrthoDB" id="200660at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19953">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039776">
        <property type="entry name" value="Pds5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663">
        <property type="entry name" value="ANDROGEN INDUCED INHIBITOR OF PROLIFERATION AS3 / PDS5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663:SF0">
        <property type="entry name" value="PRECOCIOUS DISSOCIATION OF SISTERS 5, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20168">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="591"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="1320"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1374"/>
            <end position="1405"/>
        </location>
    </feature>
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        <location>
            <begin position="1410"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1460"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1473"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1532"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1552"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1591"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1612"/>
            <end position="1621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS20459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1621" mass="180733" checksum="A8F531B8B5D1CFF9" modified="2011-10-19" version="1">MAPRRSAATEAEEQQEEDAGTVQLQFDEPLSWRPGKPIPLDTLLKRLDRLTKELSELDQETIDTSSLQKVAKEAASHQLLNHKDKGVRAYTACCIVDILRLCAPDAPFTPTQLKDFFNLTITSIIPALFEPSHPYNNQHKYVLRSLAEIKSIVLLLDVDGHENLLLHLFSTIFDGVSGSKTPSGETIAKDVQFSMQELLGVLIEDAGSLPAKVVDVMMAQFLRAAAPGIGRDKHNHVQLDENQATLLAKEEPEAYQIVKHLCQAYPDKMSRFVSQYFSDVIVDATPFPGSRDKDGEGSDEEEAPQGPSEADLRELKKAHTLIREIWKAAPQILQNVVPQVDAELSADNVHLRQLATETLGDMISGIGAAGPPPPPVLDPAAYPPLRLEDEDRAESAPANILTTPMSSISFPQTHRSTFLNFLSRKNDKVASIRAAWTTAVGYILATSAGGIGLGRDDENTLIEGLGEKLSDSDEKVRLAAVKAIECFRFRDVILKLGPKGGVNKEGSVLSTLADRCRDRKPAVRVAAMSLLAKLWAVGTGELLAGHEAVTAALGGVPSRIYNAFYANDPELNVLLDRVIYECLVPLSYPPQPKKEKGASKSAIGSNGTSQPQASSASALDENAVRAERILLLVRSLDTTAKKAFFAMQARQPQFAHVLETFIKQCDLYNGGVMDNNADKISANLQKTIKYIAQFLPDETKTTQELYRFAKANDRRNYNLIRYVVGPEHDFKTVHKALKELMKRIQSSKDPSVRDTLLPLLYRSGCLMFNRSHLATIMEYSRSDKDGLGPAAHEILNEISQRNPDLFKTHIGQLCKDLVDQAPTATKPNDPVVVETLKACSAYARKYPKDVPGERDFTRTMINYALYGQPPKAAKYAVNILCCKKDERSQVSATELLQKTLKDWEYGTPGSLNKLTAISQLELLAPKVTEDEDERILNITVQQVLLEVRTNAKGDDPDWVDDADLDEECQAKCIALKTLVNRLRSMEDVSEAKEKAKPVWKLLMKLVTAKGELSKKKETPKHHRSRLRLLAAQLLLKLCTQKHFDDELTHTDFNALALTAQDAVQEVRHGFVRKLQKYLADNRLRSRFYTILFLLAFEPNTEFKQRTETWIRSRARYFADLKQNVLESTMARLLSLLAHHPDYNSSDLDELVDHARYLLFYISLVATEDNLGLIYKYAERVKQTQDALDQGSDRHQVLSDLAQAVIRKWQEKKNWVLNVYPGKVGLPVGLYSALRSHDEAQQIAEKQFVPDGIDEKLDELLRAMERKKKRKSVDTGDYSAKRLKVQQPKTTSADSDESGNEKRPAKSRSSKKAASSSSGSKPKKTPKPKKTREPSPVIPESERRRSSRARPNLSYVERDSEDDDEEMLDGVAEWEYVDEEAEEGSGGEGKIEEEEEEESDDDDSDDDNVRSSRRGKKAKRQIGRVSRPRVAVKSKEATTEKNGAAAAREDNDSGSELSEISSEEVGDVEMEDVGGSKEERGASPEPEKEMEVVEHGEDGREHGELEPEPKPEKSSRPTRAAKRKQAAATVTKLPDRSREGRSRRSAAAAVKDDEQEEEQEKGEKEEAEQQQAEGEEENGEEEEKPATRRGGRAKETKASFKAQDKDTEATTKGTRRSARGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4L9</accession>
    <name>G0S4L9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0031480</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693590.1">
        <property type="nucleotide sequence ID" value="XM_006693527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4L9"/>
    <dbReference type="GeneID" id="18257186"/>
    <dbReference type="KEGG" id="cthr:CTHT_0031480"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_8_4_1"/>
    <dbReference type="OMA" id="DAMGRGW"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS21294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="516" mass="56826" checksum="A7E768D614EE2AFD" modified="2011-10-19" version="1">MNFARLSPTYRHGSQQDASAVVETTGEKLFDQTILLSLPSLAMCPNTSGAANVVPAEGNELSESSNAALEPQALRQISSGSVYSVFSNPTKRWIIAMASFAGFVSPMTANIYFPALNSIAKDLDVSVHLINLTLTTYMIFQAIAPTLVGDFGDMAGRRPALFAERGKYMGFVGAGINIGPALSPVLGGILAEYLGWRAIFWFCLIYAAVWLIPYALAVPETCRNVVGNGSIPARGWNMTLIDLFRRHRDKESQTIEAGVPKRKLRFPNPVHSLRVVFEKELALLLMYNTLIYLVFILIAATVSTTFADIYHLNDLELGLCYLPYGFGCCVAAIVQGYILDYNYRRIARKIGFTIDYKRGDDLSKFPIEKARLMPVYPILSAGIIAVICYGWVLQFETNLAGPLVLLFVVGLCVTGSFSILNTLVVDLYPEAPATAVAANNLVRCLFGAAGTAFIESMLQAMGRGWTYTFWALILVIFSPTLWVLSVWGPEWREERRVRKLKAKEQETKGKQAAEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4Q6</accession>
    <name>G0S4Q6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0023170</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692781.1">
        <property type="nucleotide sequence ID" value="XM_006692718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4Q6"/>
    <dbReference type="STRING" id="759272.G0S4Q6"/>
    <dbReference type="GeneID" id="18256355"/>
    <dbReference type="KEGG" id="cthr:CTHT_0023170"/>
    <dbReference type="eggNOG" id="ENOG502RZBG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032395_0_0_1"/>
    <dbReference type="OMA" id="RPREYHS"/>
    <dbReference type="OrthoDB" id="4463286at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="398"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="454"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="526" mass="56130" checksum="0BB29EEBD1F9CA26" modified="2011-10-19" version="1">MAPSPAPHDRDRSTFGSEHHPPAASSSTASPSAQRTTAVPPPAPAAAATGSPNAPTASAPPAARSASDSPRSSAQTATSARKPSPPSASRNASAPKILVKKEPESPDMPAGRHRPRKLDLSKNTTNIVSPATARPLTARDGPLGIQEIGLACLSPGLTTQDPVMKEQLQRSLAVREQQRQIIETRLQQQQQQQKDGDKDKNGSHFTAKTPGLARKRGAPPGLSIVAPSHEQFANERVIQSAPLGQTFTGRYDTHSATRHITNQPSHLGHTSHIHHVPANQTNNRLPPLADVFGRDLPSHRESNSHLTARDYREPLPSPHHPPPPPQAPLSARREYKTAEEAQHELAGGRPELLPKLVRYGGHHQPPTPPSPPHHASAQPPRDQPPQSTGYSAHDHTHSYSSSSSAQPPRQSYADPHASRAPPSSTAAANPPPPHLSASSTAAPHHGATTPLHPGMGAASAPSSSVGSKRRRDEYEAGSPPLGNGRPAVQPRRYGPFGEGRDSPETMEAKKQEFLRLCERAWDLFHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4V7</accession>
    <name>G0S4V7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0031830</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693624.1">
        <property type="nucleotide sequence ID" value="XM_006693561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4V7"/>
    <dbReference type="STRING" id="759272.G0S4V7"/>
    <dbReference type="GeneID" id="18257221"/>
    <dbReference type="KEGG" id="cthr:CTHT_0031830"/>
    <dbReference type="eggNOG" id="ENOG502ST0G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117761_1_0_1"/>
    <dbReference type="OMA" id="VNPKFWG"/>
    <dbReference type="OrthoDB" id="5334244at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="169" mass="18312" checksum="8F3162BC0D1B8FB6" modified="2011-10-19" version="1">MPKISFSTKLPPSLFPPVIRPPFIIPYLRSVATAHYYNCQWPLSSPETPETPSTTTNKSRGQNAVAAEGTPTATPIIPDKLADGDALGRTGGGKPLSSSVHPPAKPKISNASVPGHKPHLTKEQQAEVDEHNREFERTHGKVGNEPERDDRVDKSFWSGRGARSGTTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0S508</accession>
    <name>G0S508_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">25S rRNA adenine-N(1) methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0023660</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of an adenine present in helix 65 in 25S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the BMT2 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692829.1">
        <property type="nucleotide sequence ID" value="XM_006692766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S508"/>
    <dbReference type="STRING" id="759272.G0S508"/>
    <dbReference type="GeneID" id="18256404"/>
    <dbReference type="KEGG" id="cthr:CTHT_0023660"/>
    <dbReference type="eggNOG" id="ENOG502R82D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041583_1_0_1"/>
    <dbReference type="OMA" id="FHRTSKW"/>
    <dbReference type="OrthoDB" id="5954793at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016433">
        <property type="term" value="F:rRNA (adenine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03044">
        <property type="entry name" value="BMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021867">
        <property type="entry name" value="Bmt2/SAMTOR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21008:SF1">
        <property type="entry name" value="25S RRNA (ADENINE(2142)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21008">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SENSOR UPSTREAM OF MTORC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11968">
        <property type="entry name" value="Bmt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS20533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="289" mass="33035" checksum="AE27EC3642FA2E73" modified="2011-10-19" version="1">MSAKKKKQITNLANGRPPVFNKPKSFSRKATKAIINKHHLLQKRKRQALKKGDKEEEARIDKEIEALGGLQKYQEASLQGQRHDRGGDSSRVLMEWLKSVLSPEKAGPSQRLRMLEVGALSTENACSKSGFFDIERIDLNSQSQGIKQQDFMKRPLPKDQSEMFDIISLSLVLNYVPEAKERGEMLRRTTQFLFPPGRHYPTPELAANFPSLFLVLPAPCVTNSRYLDDDRLEAIMGSLGYVKVCFKQSKRLVYYLWRRGQVPEESKARFPKKEIRPGSTRNNFAVILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0S584</accession>
    <name>G0S584_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0032610</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693699.1">
        <property type="nucleotide sequence ID" value="XM_006693636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S584"/>
    <dbReference type="STRING" id="759272.G0S584"/>
    <dbReference type="GeneID" id="18257299"/>
    <dbReference type="KEGG" id="cthr:CTHT_0032610"/>
    <dbReference type="eggNOG" id="KOG0078">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_10_1_1"/>
    <dbReference type="OMA" id="FDWLIKI"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS21403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="19171" checksum="87010D5CBC80A8E8" modified="2011-10-19" version="1">MSSSNRNYDFLIKLLLIGDSGVGKSCCLLRFSEDSFTPSFITTIGIDFKIRTIELDGKRVKLQIWDTAGQERFRTITTAYYRGAMGILLVYDVTDERSFNISTERGQALADELGIPFLEVSAKTNYNIDKAFYSLAADIKKRLIDNQQKQEQAAAGNNVNVAGQGGGEGSGKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5D2</accession>
    <name>G0S5D2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative transcriptional regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0024390</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692901.1">
        <property type="nucleotide sequence ID" value="XM_006692838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5D2"/>
    <dbReference type="STRING" id="759272.G0S5D2"/>
    <dbReference type="GeneID" id="18256477"/>
    <dbReference type="KEGG" id="cthr:CTHT_0024390"/>
    <dbReference type="eggNOG" id="ENOG502QSY2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010084_0_0_1"/>
    <dbReference type="OMA" id="MTIREEP"/>
    <dbReference type="OrthoDB" id="422427at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF6">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="598"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="358"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="30"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="121"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="667"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS20605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="960" mass="106697" checksum="129A73CAFE5D6C50" modified="2011-10-19" version="1">MTIISAAEAQHTGHPAAIDQTDMQTAVNTNLIDTPNSPDMSDDELDDQSQDEYMSSGDGTSPAQEECTYDKPSNRRRTPGPGYIQALEQRLDRAEALLRQFMPNVDLTDHNLDPVIQKEFRNRQKARAQAQAMTIREEPSQEEGGDEKDDKPGSNHDNEDAKLMSMIESMGQLDLKEGGVWDFHGNEHGINFLPRPVPPPGLFSIDSPAAIGATPSANSQEAKLEQRFQLPPKDRAKKLCYYSLDCATCLLRVIHQPSFYEMFEKLYTTPQESWGNEEHRFLGLFFAVLALGCVYNVSQVSPSSPAPTYKDALEEGIKYYLSARLILQDVAECRDLCSLQAFVYLILFLQATSHISDCYAFLGIALRSCLRMGLHRHILHDKITPIEDETRRRVFHVVRQMDCYVSAILGFPILLSDEDVDQPLPSEVDDEFITREAIVKPPEGTPSFFQAFNAHNRLMGILARVVKEIYPFRERGRSAKESMSARQGSPTFLISYSRILALEKELEDWRGGLPEFWREGTEGPIEVVRVRTLLRFGFAHVQMMLYRPFLHYMSPALTAGKQVDERCYRCAAKCIEVSRNIIHIGAEIQKQAVLIGPYWFILYAIFFAILSLVFFVLENPGHVNTKQYVKDIYAGREFIANLKGRSLTADRITSALNPLFEQLSERLDTGAKQPKPNRKRSAPPALPQELKVDYHPVASGQESDNSSQQRVEEIIQPQQRGVPQQSTQLSSSSHQQLVSSGNYFLQHASLSTQDFQTLQGMIPVPITGPLTGSTGAVSTNFAAVAATAATVSSTVQDAIIQGYPQHQATQGISPSTTLPQHSTSVPNQVYALASAPTTVALDMGIMYPASNTQNSFVYPAQTHPSTGVAPQPQAQTNPTMQFYPTPAAMQHGSSTAAGTMYDGIEGQLLEPIPSWLMHTQTQNQQEHPGQGSQNDFHISLESMTASRISQGCWGGAEGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5U0</accession>
    <name>G0S5U0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GTPase-activating protein for-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0033600</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693798.1">
        <property type="nucleotide sequence ID" value="XM_006693735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5U0"/>
    <dbReference type="STRING" id="759272.G0S5U0"/>
    <dbReference type="GeneID" id="18257398"/>
    <dbReference type="KEGG" id="cthr:CTHT_0033600"/>
    <dbReference type="eggNOG" id="KOG1453">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1704">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003874_0_0_1"/>
    <dbReference type="OMA" id="GFERSPQ"/>
    <dbReference type="OrthoDB" id="79452at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09394">
        <property type="entry name" value="LIM1_Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09395">
        <property type="entry name" value="LIM2_Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000043">
        <property type="entry name" value="Rho GTPase activator Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000044">
        <property type="entry name" value="Rho GTPase activator Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF128">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN RGD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="15"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="8">
        <location>
            <begin position="887"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="135"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="260"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="493"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="793"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="556"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="631"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="203"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="510"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="535"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="795"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="821"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="852"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS21502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1077" mass="119582" checksum="D260C48026CC2BFC" modified="2011-10-19" version="1">MDEYLDNTMEAEETYICKGCGEILEEGKAFELAGNRWHLDCFRCNSCRTLLDSDANLLLLGDGSLICNNCTYSCSACGNKIEDLAILTGDQAYCEPCFRCRNCKRKIENLRYARTSHGNLCMSCHESLMARRQKKLKAAQAKREKEASPLLTDKSLPALPPNAVPPSGYAKDHLLSDSDRPTELSPPPRAAYGRTDATPRSGSRPDRSPDRTHEAHNDSSLAPSTSNYRHNRNSAIFAIDQSNGDSEGYYIPVALDPNPAPSITPTAQSMSEAFAESSKRNRDRDYYSAQKLSPAPERRADAPVTTPHIAFQEKGRQPTQDFEAPRHDKPQRRLSKRGGNPNAPSDDKKTAVSKTQYSDDFKLQEAPMGKKPADSTPTKAPAPPPHGPADKIPPPRPSQDRWKDERSEPSQSRPGLPESKLSDTYMQPRPAPQPPTQAASKEGAVYASDSSEPKLPRWSSGGDLNLEEDMARILGTDESSSSILRRVSNAVRHGRANSDASNHVRLGHSRSVSETTRGTSSPRWPKTPMAEDPMNASQVPDVTSPISLSGSAQDDPAFLKRQLRNSEQRVAELERQFNSEKDLKNLTRKVNEKRKTVSDLNAQTEIMIRQLEVLAGYVERAKKTGEPLDPRELEESAIKEFVQKLEDVKQKFQISIEKLIRERDELIEQRDQAIAERDRALMEFEQLSSKNAQLADMNNDLTHQIQERIKQQANSANGLGIYGHAKGVSTASVNVDSAGLQTGSTFIGADGEEVVEGATAVNVRKGQAKKFNWKKGSSKVAQNISKGINRAAGAFQQQDQNRSQTHPQLNNDNIGLPYNMTVAQVDSPVTTAPPPPNRSNDSGRQGFGFFSKKQNVPKSTSTNNVTPNEKLAPPPVVAEAPSTLFGSDLVERADWEKRQIPSVVTRCIEEVELRGMDVEGIYRKTGGNSLVKMIQEGFDKSLDFDISDPSLDITAVTSVLKQYFRKLPNPLLTFDVYDRVLESNSIQDEAERCAHLRETINMLPQKHRDTLEFLMFHLARVASRENENLMSPKNLAVVFAPTIMRDHSLEREMTDMHAKNLAVQFLIEHSHIIFGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5U7</accession>
    <name>G0S5U7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0033670</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693805.1">
        <property type="nucleotide sequence ID" value="XM_006693742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5U7"/>
    <dbReference type="STRING" id="759272.G0S5U7"/>
    <dbReference type="GeneID" id="18257405"/>
    <dbReference type="KEGG" id="cthr:CTHT_0033670"/>
    <dbReference type="eggNOG" id="KOG4372">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007367_0_0_1"/>
    <dbReference type="OMA" id="WSYIRPT"/>
    <dbReference type="OrthoDB" id="5368485at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF62">
        <property type="entry name" value="LIPASE ROG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="4">
        <location>
            <begin position="264"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="DUF676" evidence="4">
        <location>
            <begin position="352"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="DUF676" evidence="4">
        <location>
            <begin position="443"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="302"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="632"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="739"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="808"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="981"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1025"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1103"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="314"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="652"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="739"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="824"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="874"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1028"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1126"/>
            <end position="1154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS21509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1154" mass="126323" checksum="6F3B57DF0EDAB27F" modified="2011-10-19" version="1">MLLLHQVGSVKIGEVVRYTVTYKPSADHILPSPEFLYLRIKNTCSTPLRAAFVHGPYTLSVAAYPAHFKPFEKFENPRRYGVPEFEPMLKAGSVWNCHLVVPDNIRQTAGEGSSQHGYFGGRPNREGESASWIIEVSSQVLFSTSAAVHYEILLARDEKSLNIGSVVSVIGGQTHVPEPGRVSDFQRGAESQKDPSGLQKGVFSKAIHLKVEDTAALWNTPQLPGWDDVGWLRARSDDLVEPPTEAATDNNRPHANQQHRKHKPKKVHLVVLTHGLHSNLGSDMLFLKESIDAAVKQAKIDAKARRARERVVRRRDSSQIEAPERAADGSSHTLDARVNDGGRESNMGEVDESDSDDEEVIVRGYSGNATRTEKGIKYLGKRLAKYLLAMTYPDQPCLVTPKDASEAIVHTLKTSAFKKAGEDGHKQGSSFRSHSYGTNRTYKFTKISFIGHSLGGLVQTYAIAYIQKHSPKFFDLIQPVNFIALASPFLGLNHENPLYVKFALDFGLVGRTGQDLGLTWRAPTIARNGWGAIVSSLGEHAHKRMYGEPQPESKPLLRILPTGPAHKALKKFRNRTVYSNVVNDGIVPLRTSCLLFLDWQGLGRVEKARREAGLVETVVGFGWAELTGATVTTPRLAPWRPPDEEENGDGNDMDKNAQAKIEDLHAVPQPPSNATLEDDKQSFRAASDSYPGSSSTASLTSPLAGLLNFLRGDSPKPAQASSYKVSKIYQRGQIVKQGNMSSDQSLFGSPSASKRTAGTQAAQWTEPVSAPPKTTIFESAGDLLNPKLPSVEFLIDPAKRPRTIFHDRVYHPSDIPPPPTKAHLSTTSQLTLRLRSGVSTSQKSSSKSTCASSPTSTSNNPSSPSQRSRASTAGDGSTVHTTLSSNPDTADVTTVPNSPEDGAAMNDEDQEVDRSQMRVEEKIARAYHRGMSWRKVLVKLEPDAHNNIFVRRMFVNAFGWPVIQHLVQAHFSDAEIARTRDDDLPGSVDRARAPEEPAGLKKSGETKDVELAGIGAGVGVVRDSIQGNRDEVAKRPSEKEPHQKPPGVVLTGQAQHYCDGHAHEIVSGLGMSEPPASSSSLLTPLVTPRTELSDKFDSVTWSDRDWLDSGEDSDDDRSRRSSTGHAKKELGADTSLEKLKPSDMELDRENFIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G0S619</accession>
    <name>G0S619_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">E3 ubiquitin protein ligase</fullName>
            <ecNumber evidence="15">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CTHT_0025710</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 21">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the BRE1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="15"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693031.1">
        <property type="nucleotide sequence ID" value="XM_006692968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S619"/>
    <dbReference type="STRING" id="759272.G0S619"/>
    <dbReference type="GeneID" id="18256609"/>
    <dbReference type="KEGG" id="cthr:CTHT_0025710"/>
    <dbReference type="eggNOG" id="KOG0978">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019713_2_0_1"/>
    <dbReference type="OMA" id="YRQMQEY"/>
    <dbReference type="OrthoDB" id="654191at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033503">
        <property type="term" value="C:HULC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16499">
        <property type="entry name" value="RING-HC_Bre1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058643">
        <property type="entry name" value="BRE1-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013956">
        <property type="entry name" value="E3_ubiquit_lig_Bre1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE BRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163">
        <property type="entry name" value="RING FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08647">
        <property type="entry name" value="BRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26095">
        <property type="entry name" value="CC_Bre1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11 15 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="649"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="219"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="159"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="541"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGS20735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="701" mass="79941" checksum="77985F3CA3B68582" modified="2011-10-19" version="1">MEDRKRPASSAVDDGAPPSKRQAINGSSKDKSDVEMREEAWIEEYQKGAIYRQMLEYKRQAMSLENRVQELEKKSTDHDDHIRIMDAWVLQLLQEIDLLVTSTISSTSSQDLHPGSALAFSDSKDFQRHLGEKAKTLTSKTDAILKRLASARGEVKPEVAELESQVKTLLAQQKDLIVKVDRLETQNASLSEQYDKATLKAIKAERKLDRLRSAQVQKLEQQAIASSTRSAPKDENGSGSGNSDGNNEELKRKCHEAEAVVTKLKQQLEAALSENKALMDENSSLKIKKEVVTDEEYVRTDAFKQFKAQNEDLIKRVNHLEATNRQLREEAEKLRAERTEWKMKVEAEAQAVTAELEKELHQKDQDLARIRSVRDELNAEVMMRKAAQEQERVSITQLKELVDAQSARIEELESELGRLRSNEASSVTPDIEAIPIDELRQKYAKLEKDFEAINKELPLLEKSYKATMSLAHKKVMDHINIEETVAKLQAEKNKADQKYFAARRDMDARSHEIRMLRAQNGKSSEIISQLKEVETHNRNLISSLEKQIVSLKQDISNTMAERKRLEQLSNDATRKADACKSQIQSLTELVKAKDAAVVSMKEQLLKAETELERLKVDVKELTKDCHKWKQKAQNNMSEEEEALRNLVICSVCRSNFKNTYLRGCGHVFCNQCVEDRITNRMRKCPSCNKAFDRSDAMPAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0S653</accession>
    <name>G0S653_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Monopolin complex subunit Csm1/Pcs1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0034220</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EGS21561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006693794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S653"/>
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    <dbReference type="GeneID" id="18257460"/>
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    <dbReference type="eggNOG" id="ENOG502SC4G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029214_1_0_1"/>
    <dbReference type="OMA" id="REDNEQG"/>
    <dbReference type="OrthoDB" id="2431049at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034506">
        <property type="term" value="C:chromosome, centromeric core domain"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:nucleolus"/>
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        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0045144">
        <property type="term" value="P:meiotic sister chromatid segregation"/>
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        <property type="term" value="P:regulation of DNA-templated transcription"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23787">
        <property type="entry name" value="RWD_CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.80:FF:000001">
        <property type="entry name" value="Chromosome segregation protein (Pcs1)"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040349">
        <property type="entry name" value="Csm1/Pcs1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020981">
        <property type="entry name" value="Csm1/Pcs1_C"/>
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    <dbReference type="InterPro" id="IPR038608">
        <property type="entry name" value="Csm1/Pcs1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000637">
        <property type="entry name" value="HMGI/Y_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28006">
        <property type="entry name" value="MONOPOLIN COMPLEX SUBUNIT CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28006:SF1">
        <property type="entry name" value="MONOPOLIN COMPLEX SUBUNIT CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12539">
        <property type="entry name" value="Csm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00354">
        <property type="entry name" value="HMGI_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Monopolin complex subunit Csm1/Pcs1 C-terminal" evidence="4">
        <location>
            <begin position="380"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="202"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12539"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGS21561.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="485" mass="52568" checksum="7AE4F430D94F7E35" modified="2011-10-19" version="1">MPPVKKGKVGRPPANRVTKPVSKPTTSGHRSSDRVAAAIDESTLDEKEASAAKLSNTSSAPEKRGPGRPPKQKRIVTAEKEEIEDSVMMDAPVPTPDAAPKRGRGRPKKNAVDPLEPDAPGARRKGKIATKGPELDITQAAEVSEIPETQLKEETDDATGDREDNEQGLDEDSTQITPRQARACRRKAAAQASVSKQSPAKSPEKGDSALHKELAEMRRKYEDMKRQYEDVKSKYDDIRETGVEDANHNFIKFKKQAEEKSKVAQQLIAALQAQLAEHKEAAKEAISLRAQIEEQESMITSLQSKIDSLTSSLAEARSEIKSLNLKLAAARNAEAAANAAAAAGRQIPGSAIKGANSREARLAAAATSEAIQQATMAAQKKEDLYGDLTGLIVRSVKREDGEDKFDCIQTGRNGTLHFKLAIDADQESGADAQCHYMPQLDPNRDRALIAVLPEFLTDEISFPQSQAGKFYARVLKALNETPAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6B0</accession>
    <name>G0S6B0_CHATD</name>
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        <submittedName>
            <fullName evidence="5">60S ribosomal protein L43-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0026110</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="476" last="476">
            <title>High-resolution structures of a thermophilic eukaryotic 80S ribosome reveal atomistic details of translocation.</title>
            <authorList>
                <person name="Kisonaite M."/>
                <person name="Wild K."/>
                <person name="Lapouge K."/>
                <person name="Ruppert T."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="35079002"/>
            <dbReference type="DOI" id="10.1038/s41467-022-27967-9"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.90 ANGSTROMS) IN COMPLEX WITH ZN(2+)</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e56910" last="e56910">
            <title>Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation during pre-60S biogenesis.</title>
            <authorList>
                <person name="Lau B."/>
                <person name="Huang Z."/>
                <person name="Kellner N."/>
                <person name="Niu S."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
                <person name="Cheng J."/>
            </authorList>
            <dbReference type="PubMed" id="37129998"/>
            <dbReference type="DOI" id="10.15252/embr.202356910"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS) IN COMPLEX WITH ZN(2+)</scope>
    </reference>
    <reference evidence="13 14 15" key="4">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e57984" last="e57984">
            <title>Structural insights into coordinating 5S RNP rotation with ITS2 pre-RNA processing during ribosome formation.</title>
            <authorList>
                <person name="Thoms M."/>
                <person name="Lau B."/>
                <person name="Cheng J."/>
                <person name="Fromm L."/>
                <person name="Denk T."/>
                <person name="Kellner N."/>
                <person name="Flemming D."/>
                <person name="Fischer P."/>
                <person name="Falquet L."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="37921038"/>
            <dbReference type="DOI" id="10.15252/embr.202357984"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.12 ANGSTROMS) IN COMPLEX WITH ZN(2+)</scope>
    </reference>
    <reference evidence="9 10" key="5">
        <citation type="journal article" date="2023" name="Nat. Struct. Mol. Biol." volume="30" first="670" last="677">
            <title>Structural inventory of cotranslational protein folding by the eukaryotic RAC complex.</title>
            <authorList>
                <person name="Kisonaite M."/>
                <person name="Wild K."/>
                <person name="Lapouge K."/>
                <person name="Gese G.V."/>
                <person name="Kellner N."/>
                <person name="Hurt E."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="37081320"/>
            <dbReference type="DOI" id="10.1038/s41594-023-00973-1"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.20 ANGSTROMS) IN COMPLEX WITH ZN(2+)</scope>
    </reference>
    <reference evidence="12" key="6">
        <citation type="journal article" date="2024" name="Nat. Commun." volume="15" first="716" last="716">
            <title>Methionine aminopeptidase 2 and its autoproteolysis product have different binding sites on the ribosome.</title>
            <authorList>
                <person name="Klein M.A."/>
                <person name="Wild K."/>
                <person name="Kisonaite M."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="38267453"/>
            <dbReference type="DOI" id="10.1038/s41467-024-44862-7"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.10 ANGSTROMS) IN COMPLEX WITH ZN(2+)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL43 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693070.1">
        <property type="nucleotide sequence ID" value="XM_006693007.1"/>
    </dbReference>
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        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="Lp=1-92"/>
    </dbReference>
    <dbReference type="PDB" id="7OLD">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="Lp=1-92"/>
    </dbReference>
    <dbReference type="PDB" id="7Z3N">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="Lp=1-92"/>
    </dbReference>
    <dbReference type="PDB" id="7Z3O">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.30 A"/>
        <property type="chains" value="Lp=1-92"/>
    </dbReference>
    <dbReference type="PDB" id="8IA0">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="Lp=1-92"/>
    </dbReference>
    <dbReference type="PDB" id="8OO0">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="Lp=1-92"/>
    </dbReference>
    <dbReference type="PDB" id="8PV1">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.56 A"/>
        <property type="chains" value="Lp=1-92"/>
    </dbReference>
    <dbReference type="PDB" id="8PV2">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.63 A"/>
        <property type="chains" value="Lp=1-92"/>
    </dbReference>
    <dbReference type="PDB" id="8PV3">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="Lp=1-92"/>
    </dbReference>
    <dbReference type="PDB" id="8PV4">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="Lp=1-92"/>
    </dbReference>
    <dbReference type="PDB" id="8PV5">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.86 A"/>
        <property type="chains" value="Lp=1-92"/>
    </dbReference>
    <dbReference type="PDB" id="8PV6">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.94 A"/>
        <property type="chains" value="Lp=1-92"/>
    </dbReference>
    <dbReference type="PDB" id="8PV7">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.12 A"/>
        <property type="chains" value="Lp=1-92"/>
    </dbReference>
    <dbReference type="PDB" id="8PV8">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.91 A"/>
        <property type="chains" value="Lp=1-92"/>
    </dbReference>
    <dbReference type="PDB" id="8PVK">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.55 A"/>
        <property type="chains" value="Lp=1-92"/>
    </dbReference>
    <dbReference type="PDB" id="8PVL">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.19 A"/>
        <property type="chains" value="Lp=1-92"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6B0"/>
    <dbReference type="EMDB" id="EMD-12976"/>
    <dbReference type="EMDB" id="EMD-12977"/>
    <dbReference type="EMDB" id="EMD-14479"/>
    <dbReference type="EMDB" id="EMD-14480"/>
    <dbReference type="EMDB" id="EMD-17004"/>
    <dbReference type="EMDB" id="EMD-17950"/>
    <dbReference type="EMDB" id="EMD-17951"/>
    <dbReference type="EMDB" id="EMD-17952"/>
    <dbReference type="EMDB" id="EMD-17953"/>
    <dbReference type="EMDB" id="EMD-17954"/>
    <dbReference type="EMDB" id="EMD-17955"/>
    <dbReference type="EMDB" id="EMD-17956"/>
    <dbReference type="EMDB" id="EMD-17957"/>
    <dbReference type="EMDB" id="EMD-17969"/>
    <dbReference type="EMDB" id="EMD-17970"/>
    <dbReference type="EMDB" id="EMD-35290"/>
    <dbReference type="SMR" id="G0S6B0"/>
    <dbReference type="STRING" id="759272.G0S6B0"/>
    <dbReference type="GeneID" id="18256649"/>
    <dbReference type="KEGG" id="cthr:CTHT_0026110"/>
    <dbReference type="eggNOG" id="KOG0402">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141199_2_1_1"/>
    <dbReference type="OMA" id="GPRYGRK"/>
    <dbReference type="OrthoDB" id="10258345at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.30:FF:000002">
        <property type="entry name" value="60S ribosomal protein L37a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00327">
        <property type="entry name" value="Ribosomal_eL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002674">
        <property type="entry name" value="Ribosomal_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050522">
        <property type="entry name" value="Ribosomal_protein_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00280">
        <property type="entry name" value="eL43_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003058">
        <property type="entry name" value="PRK03976.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01780">
        <property type="entry name" value="Ribosomal_L37ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7 8 9" id="KW-0002">3D-structure</keyword>
    <keyword evidence="7 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 7 8" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7 8 9">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8 9">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8 9">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8 9">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS20774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="7OLC"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="7OLD"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="7Z3N"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="7Z3O"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="8IA0"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="8OO0"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="8PV1"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="8PV2"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="8PV3"/>
        </source>
    </evidence>
    <sequence length="92" mass="10137" checksum="89DA3F55B525AEB9" modified="2011-10-19" version="1">MSKRTKKVGISGKYGTRYGASLRKLVKKQEVTQHARYTCTFCGKNSVRRTAVGIWSCKSCKKTMAGGAYTVSTPAAAAMRSTLRRLREITEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6B1</accession>
    <name>G0S6B1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PHD and RING finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0026120</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693071.1">
        <property type="nucleotide sequence ID" value="XM_006693008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6B1"/>
    <dbReference type="GeneID" id="18256650"/>
    <dbReference type="KEGG" id="cthr:CTHT_0026120"/>
    <dbReference type="eggNOG" id="KOG0825">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026721_0_0_1"/>
    <dbReference type="OMA" id="GDWYCME"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15545">
        <property type="entry name" value="PHD_BAZ2A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047157">
        <property type="entry name" value="PHRF1/Atg35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12618">
        <property type="entry name" value="PHD AND RING FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12618:SF20">
        <property type="entry name" value="PHD AND RING FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="6"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="147"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="307"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="365"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="476"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="523"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="551"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS20775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="644" mass="72836" checksum="1FCC5D07794D60B8" modified="2011-10-19" version="1">MADHQCIICLDPLEVEPEGSAPPTPAQLKLLQDLKDQHERLAIEDPEALHKINEKTATSGPGSESYVAEILACGHMLHDSCLREWSDKANSCPICRQTFNIVRVYEKVGGKYLSTRRVEDKKQMPEFDFRAWAEENDEVWDDDDLPSNPCPVCNSTDHEEVLLLCDGCDACYHTYCIGLDSIPAGSWFCMECEHALGPDLSQSRDGAEGNHPGPRRLYYFPRTQASMRRARQRARSDDWQGAWGRITGHIWEALELDLDYHDEDPEVFEGLRRSRQLREQERREHERWLQRLNIASRLGAREVFRSNLPQFARPEPPQPQDTQESRKEQLAWSALEKARECESRKRSRSASAEPQEEHHHEPERKLKRPRTRRLPPHNHTNGESSTAGKNLAGPSHRADAAPSDAQPSFLSALLKEVEMSTPSDEETLVNMFGPIPGAHSPARSPSIGTITPPRASSPQMTLSSHIGPNYPPAHYSPTRASSSASSRQQLPSPNRKLQPSRGRPSSPENSDSESRGCALRQAAQKSAPQLVQSTVHHRPLELRQPQPRRAQNVTLSRSENTSPTRSNLPLEMKQSISEIVRTALKPHWHSRKLTAEQYETINRDVSRRIYEQVKDPSAVNEEMKQRWQITATQEVARAVASLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6B8</accession>
    <name>G0S6B8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hsp90 chaperone protein kinase-targeting subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0026190</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC37 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693078.1">
        <property type="nucleotide sequence ID" value="XM_006693015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6B8"/>
    <dbReference type="STRING" id="759272.G0S6B8"/>
    <dbReference type="DNASU" id="18256657"/>
    <dbReference type="GeneID" id="18256657"/>
    <dbReference type="KEGG" id="cthr:CTHT_0026190"/>
    <dbReference type="eggNOG" id="KOG2260">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033261_0_0_1"/>
    <dbReference type="OMA" id="NYSKWDQ"/>
    <dbReference type="OrthoDB" id="440202at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.610:FF:000002">
        <property type="entry name" value="Hsp90 co-chaperone Cdc37, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.610">
        <property type="entry name" value="Cdc37, Hsp90 binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004918">
        <property type="entry name" value="Cdc37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013873">
        <property type="entry name" value="Cdc37_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013874">
        <property type="entry name" value="Cdc37_Hsp90-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038189">
        <property type="entry name" value="Cdc37_Hsp90-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013855">
        <property type="entry name" value="Cdc37_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800">
        <property type="entry name" value="CDC37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800:SF4">
        <property type="entry name" value="HSP90 CO-CHAPERONE CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08564">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08565">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03234">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01069">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01070">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01071">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101391">
        <property type="entry name" value="Hsp90 co-chaperone CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cdc37 N-terminal" evidence="9">
        <location>
            <begin position="2"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 Hsp90 binding" evidence="8">
        <location>
            <begin position="201"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 C-terminal" evidence="7">
        <location>
            <begin position="391"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="197"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="466"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="466"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="477"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS20782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="503" mass="57128" checksum="89A0004498F0A2F1" modified="2011-10-19" version="1">MPVDYSKWDALELSDDSDIEVHPNVDKRSFIRAKQAQIHQERAQRRHQIETLKYERIINDALKKRIAELIECLKEHREEAKERNPGELAFQCVMELAAKLDPKDDEPPPRPAGVHDAEEPLPTYTKMMATLLDQVNKTLDEKKVTPDQRYEQLIVEVGEHLTKVTNLQEDLLKKLAELEREENRKITSDHIHTGFNSSFINKSKSSSSGPSSSSSKPSETKVELLNPNYKDPSTDPEYLNRPDDEEITASPLARQFCNIRATDYRESHSFLLEHPELLSERETDGMLMLAFDAQLENKSDFARNCVHQALLTQYCRALGRDGVALFFKRITTPGHNAQEVFLKDVQDTYMRIKNRAREIILQRAKDEAEGKTGQVEQIQLHAVEPGTTINIRVPDPNSDDPEEKRCREIFESFSPAMRKALESGKLEEVNKVLGEMKVDEAEELVGKLGEANILSLEEELIDATTEEGKEKLKKMEQSAQEAKNAGSSAQSAGDDLEVIDDPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0S711</accession>
    <name>G0S711_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0035760</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694005.1">
        <property type="nucleotide sequence ID" value="XM_006693942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S711"/>
    <dbReference type="STRING" id="759272.G0S711"/>
    <dbReference type="GeneID" id="18257614"/>
    <dbReference type="KEGG" id="cthr:CTHT_0035760"/>
    <dbReference type="eggNOG" id="ENOG502SSIP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044083_1_1_1"/>
    <dbReference type="OMA" id="RIWYEAI"/>
    <dbReference type="OrthoDB" id="6123at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01833">
        <property type="entry name" value="XynB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051532">
        <property type="entry name" value="Ester_Hydrolysis_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383:SF31">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383">
        <property type="entry name" value="THIOESTERASE 1/PROTEASE 1/LYSOPHOSPHOLIPASE L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409345" description="SGNH hydrolase-type esterase domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="2">
        <location>
            <begin position="44"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS21709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="262" mass="28567" checksum="971FD8368CF450BF" modified="2011-10-19" version="1">MVARSLAGLLTLFLPFTAQAVPIGNSTIEARALGNGVPLRIIPLGASIVYGQASTDGNGFRAHLRASLTGPRGNLVNMVGSRKSGTMLDNDVEGWPGFRVDQVHVKATSPNGGPVARFKPNVILINAGTNDALQSHSLNDIGRRMESMLIDLWNRSPRAVILLSTLIINRKPEIERNVITINAQYRTLARRLRREGRHIVLVEMHCDPNAPTAHDMADTIHPNDSGYKKMADLWYRGMLEASGRGWLQPPETVEGLPDDGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0S730</accession>
    <name>G0S730_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cell cycle control protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0035950</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2025" name="Cell Res." volume="35" first="296" last="308">
            <title>Structural insights into spliceosome fidelity: DHX35-GPATCH1- mediated rejection of aberrant splicing substrates.</title>
            <authorList>
                <person name="Li Y."/>
                <person name="Fischer P."/>
                <person name="Wang M."/>
                <person name="Zhou Q."/>
                <person name="Song A."/>
                <person name="Yuan R."/>
                <person name="Meng W."/>
                <person name="Chen F.X."/>
                <person name="Luhrmann R."/>
                <person name="Lau B."/>
                <person name="Hurt E."/>
                <person name="Cheng J."/>
            </authorList>
            <dbReference type="PubMed" id="40016598"/>
            <dbReference type="DOI" id="10.1038/s41422-025-01084-w"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.80 ANGSTROMS) IN COMPLEX WITH ZN(2+)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWF19 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694024.1">
        <property type="nucleotide sequence ID" value="XM_006693961.1"/>
    </dbReference>
    <dbReference type="PDB" id="9L5R">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="U=1-757"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S730"/>
    <dbReference type="EMDB" id="EMD-62841"/>
    <dbReference type="SMR" id="G0S730"/>
    <dbReference type="STRING" id="759272.G0S730"/>
    <dbReference type="GeneID" id="18257633"/>
    <dbReference type="KEGG" id="cthr:CTHT_0035950"/>
    <dbReference type="eggNOG" id="KOG2477">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015540_2_1_1"/>
    <dbReference type="OMA" id="FMKCLTR"/>
    <dbReference type="OrthoDB" id="2113965at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF5">
        <property type="entry name" value="CWF19-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-0002">3D-structure</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Cwf19-like C-terminal" evidence="4">
        <location>
            <begin position="501"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like protein C-terminal" evidence="3">
        <location>
            <begin position="639"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="14"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="512"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="515"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="562"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="609"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS21728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="9L5R"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="757" mass="87980" checksum="B9C4D13C6B0472F1" modified="2011-10-19" version="1">MELDGLAAFEKALAAEKAERERAAREKEERRERKHRHHHHHHRSRSKSPKRDRDSDRHKHRSRSRDRDRHRDRDRDHDRHELPGRDGEKDRRSRHLSRERDSDEDRHRDRHSRRSRDEGDRDRSDRHRHRRRSRSRSKERDRDRYDKHTVKDTKDLKSSDPKADLPLPDEEKTPAGSTPLVRDAWMTAPSAMDIDYIHRRQKDKSPSPVREEPRLVLHKRELNTRLADDDWKEPAPAKKREVNYTFGDEGSEWRMTKLKGVYTIAEQTGRSVEDVALERYGSLEVFDEAMEEKMELDRRKLYGPGYVGKEKPTGNLYRERMAKTRPQPARSPSPEPQQGLVIEDKIQPAPPMDQSALNRLRAGYLRAKFRKAPEAAKLEEEYNKAAAAFTTGAASNNAIVLDASYNRMLAGPRHEVKAVTTKRGRERGQVEANEDMTIEDMISEERRTRGQPGGEGLRLAERIAKDARFENDLEYLEENAEWLAKRVHKTDLSLKNIAVNEYQKLNRILETCPLCYHEDRNPPQNLPIAPVISLGTRTYLTLAPEPEINGAEGGAVIVPLTHHTNLLECDDDEWEEIRNFMKSLTRLYHDQGRDVIFYENAAAPKRRQHAALVAVPIPYELGDTAPAFFREAMLSSDEEWAQHRKVIDTGKKAKEALGRMAFRRSIAKEMPYFHVWFNLDGGLGHIVEDENKWPKGDLFAREVIGGMLDAEPDVIKKQGRWTRSDERVEGFKKRWRKFDWTRVLTEGIVVQTDGASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7S2</accession>
    <name>G0S7S2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Translocase of outer membrane 40 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0028620</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="16 17 18" key="2">
        <citation type="journal article" date="2025" name="Proc. Natl. Acad. Sci. U.S.A." volume="122" first="e2507279122" last="e2507279122">
            <title>Structures of &amp;lt;i&amp;gt;Chaetomium thermophilum&amp;lt;/i&amp;gt; TOM complexes with bound preproteins.</title>
            <authorList>
                <person name="Agip A.A."/>
                <person name="Ornelas P."/>
                <person name="Yang T.J."/>
                <person name="Uboldi E."/>
                <person name="Hader S."/>
                <person name="McDowell M.A."/>
                <person name="Kuhlbrandt W."/>
            </authorList>
            <dbReference type="PubMed" id="40674418"/>
            <dbReference type="DOI" id="10.1073/pnas.2507279122"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Channel-forming protein essential for import of protein precursors into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom40 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693318.1">
        <property type="nucleotide sequence ID" value="XM_006693255.1"/>
    </dbReference>
    <dbReference type="PDB" id="9I6B">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="A/B=1-347"/>
    </dbReference>
    <dbReference type="PDB" id="9I7P">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="A/B=1-347"/>
    </dbReference>
    <dbReference type="PDB" id="9I7S">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="A/B=1-347"/>
    </dbReference>
    <dbReference type="PDB" id="9I7T">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.80 A"/>
        <property type="chains" value="A/B=1-347"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7S2"/>
    <dbReference type="EMDB" id="EMD-52652"/>
    <dbReference type="EMDB" id="EMD-52658"/>
    <dbReference type="EMDB" id="EMD-52660"/>
    <dbReference type="EMDB" id="EMD-52661"/>
    <dbReference type="STRING" id="759272.G0S7S2"/>
    <dbReference type="GeneID" id="18256900"/>
    <dbReference type="KEGG" id="cthr:CTHT_0028620"/>
    <dbReference type="eggNOG" id="KOG3296">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042174_0_0_1"/>
    <dbReference type="OMA" id="TRFNYRW"/>
    <dbReference type="OrthoDB" id="19656at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07305">
        <property type="entry name" value="Porin3_Tom40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.10:FF:000009">
        <property type="entry name" value="Mitochondrial import receptor subunit TOM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037930">
        <property type="entry name" value="Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10802">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="16 17 18" id="KW-0002">3D-structure</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9" id="KW-0626">Porin</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00078731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS21022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="9I6B"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PDB" id="9I7P"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PDB" id="9I7S"/>
        </source>
    </evidence>
    <sequence length="347" mass="37818" checksum="5C6B0DDC59192F2B" modified="2011-10-19" version="1">MASSTNSPLAFLRSNPVFASLSDLYDAFQERRQKLGLSNPGLVENIAKEVQRDVLTTNLMFSGLRADLTKAFSLNPLFQVSHQFAMGERLSPYTFAALYGTSKMFAQGNIDDQGNLSTTFNYRWTPSFTTKTRFQITPGATGQDMAQFEHEYSGADFTATIKALNPSFLEGGLTGIFVGQYLQSITPKLSLGLEAVWQRAGLTQGPDTAISYVGRYKTENWIASAQLQAQGALNASYWQRLGEKVQAGVDMTLSVNPGAAMMGGPTKEGITTFGAKYDFRMSTFRAQIDTKGKLSCVLEKRVAAPVMMTFAADVDHFTQQAKVGVGISIEAGGEELQDQQPAPNIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0S838</accession>
    <name>G0S838_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CASTOR ACT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0029260</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693381.1">
        <property type="nucleotide sequence ID" value="XM_006693318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S838"/>
    <dbReference type="GeneID" id="18256964"/>
    <dbReference type="KEGG" id="cthr:CTHT_0029260"/>
    <dbReference type="eggNOG" id="ENOG502RXBJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036623_1_0_1"/>
    <dbReference type="OMA" id="CPRQLAN"/>
    <dbReference type="OrthoDB" id="58529at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.10">
        <property type="entry name" value="VC0802-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051719">
        <property type="entry name" value="CASTOR_mTORC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31131:SF6">
        <property type="entry name" value="CASTOR ACT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31131">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CASTOR ACT" evidence="2">
        <location>
            <begin position="87"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS21085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="421" mass="44912" checksum="D6541B57BB89DB0D" modified="2011-10-19" version="1">MEQGVNMNAQVSFLPILKILLPPSQDPTGQNTASLSSITSQYQHVFLNISVTPIECSIVCDSAWAESEFIPAIKRLPKDKAKSVLISKDKYAALCVITGSLDAGSRVADLTSPLALANIPIFFITTYYSDFILVPIRDRQAVVKTLLGKGFVFSQDDQSRLITPASGRPHSSSYSNNTVYPYTHDWSSAIQSRASNYASENCVDPNTTPPSPPPPSPPLSPTATLTALDELQERTFSLLKKRHVVPYVQPNLTLVHCTGIQHHSSSSSPRGASNGGSRRNSRPSWVDTIDAKLHTALVAALVSQPRFVSVTFAMDDPPSLLLDRELLPLFGGSLVGPTGEGAGLVPVFLDLADLPFEATGIVSGVAGRLVKEMGCLVSDGERAGGGELSYLSTARAGAVILEEGVAGEAMAVLKRGLVEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>G0S884</accession>
    <name>G0S884_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0037920</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694214.1">
        <property type="nucleotide sequence ID" value="XM_006694151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S884"/>
    <dbReference type="STRING" id="759272.G0S884"/>
    <dbReference type="GeneID" id="18257830"/>
    <dbReference type="KEGG" id="cthr:CTHT_0037920"/>
    <dbReference type="eggNOG" id="ENOG502QURB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005024_1_0_1"/>
    <dbReference type="OMA" id="ISKWSFA"/>
    <dbReference type="OrthoDB" id="5370478at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="450"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="79"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="160"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="482"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1084"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="421"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="503"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1117"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1161"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1182"/>
            <end position="1191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS21918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1278" mass="140289" checksum="3705B0F9A2E366FF" modified="2011-10-19" version="1">METTPVATAHLGSMWRMLPSTLAGTVLRCWPGRPQSLTPGKEQGPAPSSHCLGLALLALGVWFDLPGAPAPCPPHPPHWATGDGCQQPDCSSSPSKKHRDDSGPTTVQLFAPARPLHPTPFRTPTIRPRAVSLPAARCKLLQLTLHLQAILPTYLPSASIHRSSSRFGSGSGFSSTVQCSRDSSPTEAPHSPEHISPPTHCRDPVSPSSASASRSNRSRLESTNKQQADLLRDIVSIRAGGQEVEKEGKEDRTRQDQTGPRITGRQEAQDAQSCSPHPLTRPASRRRRLLAPLSILSPPEPPDSDAASPTPTSAQHQHQHQQQPHPKRKFHDAFAPAAPDVPIEPATVPEQQHTAAHHPPQPPQPIQPERLPNIRQPLPRSPPRPAAVGAVRTQGLTAPPAPSPGEDDGRSPGGQQPTMMAAAAASPSSPGAAPDFKKGIKRAPLRSSIACHRCRKSKIKCNNTGGDAPCDTCIRNGKECTYPEVAPAPPKRSEPATGPKLDQGSERKRPRRTEDVVRASDALSGPAIAEEVLSAKFLTETVWNQLFDIYRLHFATELPFIHLATLKEKLGNRFRSKPSDTAPDFNLVLLGILTLTARFHTTLVSYITARRNSELVSPVQKSRSSGPASDAASASEYYADILTKALGGLRMSMTVASVERVQAFLMLGLYEWSQARPRVGGMAAWMYVGVAIRMAQALGLGDGDREPSRVSFHKRQQTSLDSIPPGQRIIAKEIRRRTMFSCLILDRLLGCGKDRVSTIRSEDLQIQLPCSEVSFDLSEEVYTGFLKPLPGQKPDDNRKISDSVLGRFVRLVDLWGEISKWSFAGGRFTEEHPPWSPDSTFYQLRAKLEAFYEDLPEHFRWSQSNYYKHENHQASSVYVSLHMLGSICRIMLHREYIPFIPILCDRPIGPLDEPTFPAGQEPSGFWETSAEHVFDAAKVIVDLTEICREKLPMSSLVLFAVWTAAFVGIYAVHFPHMDTKEHMLPKDVVGDLDVMKDGPTGLMYKMLSHMATYLKMAETYVTYFREMTCFYEMVKQDYERYKGRRPPASNSGETKFSVRMGGGGLEEWRQQAFKVVNNGEILAVDEDKHSSSRASTVEPASSVGPDSMHADHAKTPRSASMSFTPINSAHLSHPSHPSHPSHPDPSDPETAAASALWRFQQPLQQHSPQSAGAMPSPQLSHPHPHSHHPHPVHPATAGQQQQQVALAMPKLPAYSSSEVASYLEQNQSMPWSLAPGGVDQFAYGTDETAPVETGNPFWGGNFPAEPWMLQQVTPLHHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8F0</accession>
    <name>G0S8F0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Orotate phosphoribosyltransferase</fullName>
            <ecNumber evidence="5">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0029650</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="5"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693420.1">
        <property type="nucleotide sequence ID" value="XM_006693357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8F0"/>
    <dbReference type="STRING" id="759272.G0S8F0"/>
    <dbReference type="GeneID" id="18257003"/>
    <dbReference type="KEGG" id="cthr:CTHT_0029650"/>
    <dbReference type="eggNOG" id="KOG1377">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074878_0_0_1"/>
    <dbReference type="OMA" id="SPFFMNA"/>
    <dbReference type="OrthoDB" id="5553476at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046132">
        <property type="term" value="P:pyrimidine ribonucleoside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000008">
        <property type="entry name" value="Orotate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46683">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46683:SF1">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="11">
        <location>
            <begin position="51"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS21124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="234" mass="25129" checksum="F5888669F3BD1262" modified="2011-10-19" version="1">MSALPDYKQAFLHAAITGGVLKFGSFELKSKRISPYFFNAGDFYRADLLEAIATAYAKAIAEARASGALGDFDVIFGPAYKGIPLATAATIRLGQLNPEKFGDKCYSFDRKEAKDHGEGGNIVGAPLKGKRVLIVDDVITAGTAKREAIAKIQKEGGEVAGIVVALDRQEKLPSPDGDDSKPMPSAIGELRKEYGLPIIAILTLDDIIAGMKGLASEEDIRKTEEYRAKYKATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8M9</accession>
    <name>G0S8M9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative meiosis-specific protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0038660</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694285.1">
        <property type="nucleotide sequence ID" value="XM_006694222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8M9"/>
    <dbReference type="GeneID" id="18257904"/>
    <dbReference type="KEGG" id="cthr:CTHT_0038660"/>
    <dbReference type="eggNOG" id="ENOG502R1FS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026383_1_1_1"/>
    <dbReference type="OMA" id="YLICHAD"/>
    <dbReference type="OrthoDB" id="2288358at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1390">
        <property type="entry name" value="NDT80 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052605">
        <property type="entry name" value="Fungal_trans_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024061">
        <property type="entry name" value="NDT80_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037141">
        <property type="entry name" value="NDT80_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144">
        <property type="entry name" value="MEIOSIS-SPECIFIC TRANSCRIPTION FACTOR NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144:SF2">
        <property type="entry name" value="MEIOSIS-SPECIFIC TRANSCRIPTION FACTOR NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05224">
        <property type="entry name" value="NDT80_PhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51517">
        <property type="entry name" value="NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NDT80" evidence="4">
        <location>
            <begin position="62"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="NDT80" evidence="2">
        <location>
            <begin position="62"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="199"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="463"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="526"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="203"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="237"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="489"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="526"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="554"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="564"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS21989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="594" mass="63401" checksum="A014524FA5CF9F4F" modified="2011-10-19" version="1">MAYPYFASVPSTYSYSSSTSGQGMAHAHRTALPHPAPHLSARDLYSTATPAFRRPDHLPRSPSFGAIRRHNALSPMSTQYGSLKMESGYHHHGSKTQPSIPPLISMTNCGQLVYSDGTPIKPEISGIIDKGFFIADNEWTCYRRNYFSCVCSFTLQPLLPQTPIQFQPNNSNQSYTVHGFAMCISAVVSDNESHTIELVQHTPKRDKGPIAKPDKIRLSPKPPQPHHPLSGIYDSGSLASSRYDPQTTSAPGSTALYGQSQQTSAPTEHTFERIQFKQATANNGKRRAAQQYYHLIVELWADIGIQQGSDPWIKVAYRKSAKMIVRGRSPGHYQSERRGSNSSGHGAGGAGGAGALGGAAPGGYGALLGPGDYTSSGLAPYGGSAYDPRSGAYTRHHHDLTMTGTDPMMSAEDVKSITEAKGYQYYASTIYENPAAEGHADTRHHTHSHHQPPQGQVELFSHSRNDTDSIGSTSGAAFDPTKIKPDPTPSSSTADTTSTLPASSASGPSSSLPSLFSSYNSSNGTSSSYYSASPAGQRCGRFESKPTSVGQYPGHHYGTGSVGVHHHHSGHHGAHHGGHHLPVIAAPGGGMSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8Z9</accession>
    <name>G0S8Z9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein bL33m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0044030</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694795.1">
        <property type="nucleotide sequence ID" value="XM_006694732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8Z9"/>
    <dbReference type="STRING" id="759272.G0S8Z9"/>
    <dbReference type="GeneID" id="18258441"/>
    <dbReference type="KEGG" id="cthr:CTHT_0044030"/>
    <dbReference type="eggNOG" id="ENOG502S7R4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2061231_0_0_1"/>
    <dbReference type="OrthoDB" id="275534at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="entry name" value="Ribosomal protein L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052008">
        <property type="entry name" value="Mitoribosomal_protein_bL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_bL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="Ribosomal_bL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47037">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L33, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47037:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL33M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS19910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="119" mass="12815" checksum="EF0E4C88522C7DDC" modified="2011-10-19" version="1">MGKWTSKPTDGGELDSQGSAVLAVAAAAAAAAAAANPDADADDDGDASLPRPHSPQFQTTNMAKKAKSRVISVRLVSMAMTGYFYTFTRPRTSLPLSMIKYDPIVRRRVLFLEQKRKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9J7</accession>
    <name>G0S9J7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0046130</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694993.1">
        <property type="nucleotide sequence ID" value="XM_006694930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9J7"/>
    <dbReference type="STRING" id="759272.G0S9J7"/>
    <dbReference type="GeneID" id="18258651"/>
    <dbReference type="KEGG" id="cthr:CTHT_0046130"/>
    <dbReference type="eggNOG" id="ENOG502S7CF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051290_0_0_1"/>
    <dbReference type="OMA" id="FVDPRNC"/>
    <dbReference type="OrthoDB" id="2967263at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS20108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="353" mass="39400" checksum="61977380683035FD" modified="2011-10-19" version="1">MATSAPQLQNKYEDLSGVKTDADGNPYNALINACEDNPIKIQALYTTHRTTRNAQQREKFLSPDFKGLIIDPVLLRLEKPDIEPGFKDERHCLVFWARPPEHILKLAAHLQSLLLKAAPSKCLWLATNLIEPSADVVSRLPPDLWLMPLHRMHMTTLEIAHSKTADEIAGLVSKLSDIIPTLTSLPSIRRARVVKPMISYDLSAVAVSFVPAAGEKVLSPPPAQPAPKTVQHAGLLVGSVEESDRYTYHHLRRDAFDIAAGTGTPIGSRYVVPSAHITLARYLTDKDHKTPEQRQRWVQAIEDINRWLEQEVWDVEDGEFIGEWIVGQERGLDCRCGALWYGGGRTIMVGEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9K0</accession>
    <name>G0S9K0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">D-aminoacyl-tRNA deacylase</fullName>
            <ecNumber evidence="2 6">3.1.1.96</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0046160</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a D-aminoacyl-tRNA + H2O = a tRNA + a D-alpha-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>glycyl-tRNA(Ala) + H2O = tRNA(Ala) + glycine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the DTD family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="2 6"/>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694996.1">
        <property type="nucleotide sequence ID" value="XM_006694933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9K0"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="275783at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:D-tyrosyl-tRNA(Tyr) deacylase activity"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0106026">
        <property type="term" value="F:Gly-tRNA(Ala) deacylase activity"/>
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        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.80.10:FF:000001">
        <property type="entry name" value="D-aminoacyl-tRNA deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="entry name" value="D-tyrosyl-tRNA(Tyr) deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00256">
        <property type="entry name" value="D-aminoacyl-tRNA deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472:SF5">
        <property type="entry name" value="D-AMINOACYL-TRNA DEACYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="D-TYROSYL-TRNA TYR DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="DTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020007"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS20111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="165" mass="18113" checksum="538342FB5BF82D72" modified="2011-10-19" version="1">MKAILQRVLSASVTVDQQVVSSIGKGVLVFAAVAPGDTEKDAESLAAKVLKLKLWDDESGKRWRKNVQEINGEVLCVSQFTLLASTKKGNKPDFHGALAPDEARKLYEHFYKKVQEGYVADRVKNGVFQAMMQVALVTIEVSVQPKEKEDKKAKSEPVTPKEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9M5</accession>
    <name>G0S9M5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0046430</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695021.1">
        <property type="nucleotide sequence ID" value="XM_006694958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9M5"/>
    <dbReference type="STRING" id="759272.G0S9M5"/>
    <dbReference type="GeneID" id="18258681"/>
    <dbReference type="KEGG" id="cthr:CTHT_0046430"/>
    <dbReference type="eggNOG" id="ENOG502SKB6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024590_0_0_1"/>
    <dbReference type="OMA" id="AKWFWEN"/>
    <dbReference type="OrthoDB" id="3595585at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="541" mass="60209" checksum="6176F5C4F4B5188F" modified="2011-10-19" version="1">MAMKDPSVEKASSTPVLDTPYVRLHITPLDPDLIKTVLSSALLPKARNISYHTIETFPEKRYGFLELPYEDAEKLRKKLNGATLKGVKIRIERAKPSRVPEPLGPEAIARENAVAIGSADVTGLDKSKPKKRKRDPEVLSGIVLKDGRKVKRGWTTAEDPREKKMKKDKEVKKRKRENEPKKQAKSKYTDHAECLVKTILPANVSAMMDATPLKKKKGKSREVTVHEFEKTTKFPTFLKTSSTSAQSKPVLEFVDGKGWVDENGNVVEVVKTRPPAPTKVDTSSEMKESSKQNLPGGNGSSIAGDDEASSDHEGTAHYNEDGRHLTPDSTTNDALLVPELPRPSSQKAKPTGPKEGLTIKIPPATPSEPKVHPLEALFKRPKQPEGEAADEGPEAKGFSFFGDNEEGVEEDCSGVDADGLPGFQEPLTPFTRKDLELRGIRSAAPTPDTAHPSRRFIPWDNEDNDEEIGREETPQGHEEAEALPSNDIMPENDSEGKKASDFEKWFWENRGELNRAWKRRRKLAGKEKRYRENKARMARAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0SA03</accession>
    <name>G0SA03_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0040530</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694460.1">
        <property type="nucleotide sequence ID" value="XM_006694397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SA03"/>
    <dbReference type="STRING" id="759272.G0SA03"/>
    <dbReference type="GeneID" id="18258091"/>
    <dbReference type="KEGG" id="cthr:CTHT_0040530"/>
    <dbReference type="eggNOG" id="ENOG502RZFD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021587_2_0_1"/>
    <dbReference type="OrthoDB" id="5404323at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="603"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="708"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="632"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="669"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="752" mass="79846" checksum="CDDBE4352B08C1F8" modified="2011-10-19" version="1">MFLHAGASLHGHEYSQRASSAAASAAPNLRPPPLLRSAFAPPKQRNLTADDAAVTPVRQRPASDCIPRDSSPMVRFRDPHDETQSALATHDESVSESELSEATFSIDGSTVVSKTRRHRNRRVLHKSTTYGLGYPTPRILGKTKVVQKVFLPRLLLQLQKVGSDGRTVPVLEVFPASRIAGPVVSPRLVKKCPNIFRVKRHLGYDDIVLVRRDDDDHASSDAAENESDENLEGKNLLAVYSPLKHSDEAEIVLHDGSVWLAKPLPNGCYDFMHTDAEGKTTTARWARRHNLSSTPTSGDSLGQAGAPQVRYTFSVLNPNTRRHPVMATLTPFSLEVQDTYTSVSPSHYRTPPITRTGRSASVTSVPPPTSPSTDLSVSPSPSSPDQRIIYAVDNATKFLIAATALWVALSENWSQNYGNSPAIVPGLGQGSSLTSSSAAALPLVNGSASSTTRSRRNTWTRGSTLDSVRQSDPGTTDPPSASSSVKFGSLKRFSLPAYQPAARCNSLRACISQPSTPLGSRTSTPVPGASPSVAANEGTPIVTPTIRAVPPLYAPKRATITGATFTPLREPSASDAAGGVVDDNSDDSGIGIAAIAPGTTTSMVADSAPRSEPAPPPALAPSATPTQITSTQKQQQQQQQQPLQLEGQQQGKTRRKRFSFPLSLTLHRASGSRSASAAATPTTPSSPAVVIVPGKKSVELNTAAMAFDVPSPMGMPNGLNGSGLAKKPSMRARISRWFQKLGPGSSSNAHTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0SA40</accession>
    <name>G0SA40_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetyltransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0040910</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694497.1">
        <property type="nucleotide sequence ID" value="XM_006694434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SA40"/>
    <dbReference type="GeneID" id="18258129"/>
    <dbReference type="KEGG" id="cthr:CTHT_0040910"/>
    <dbReference type="eggNOG" id="ENOG502SYW6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086503_2_0_1"/>
    <dbReference type="OMA" id="DMVWWAG"/>
    <dbReference type="OrthoDB" id="10039976at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053144">
        <property type="entry name" value="Acetyltransferase_Butenolide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43233">
        <property type="entry name" value="FAMILY N-ACETYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43233:SF1">
        <property type="entry name" value="FAMILY N-ACETYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="28"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS19612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="207" mass="23804" checksum="3DD8764268D0399D" modified="2011-10-19" version="1">MPHIDSYRTWSRQVHGQTYTISTDPRLIQYDALDAAFRSDMLYWAQPLSPELMQRCVEQSLCFALYVVDNDGRIKGEQNDVHGNTETKGTETLQDPESKIQMVGFARLITDHVTFGYLTDVYVLSEHQGRGLGRWMMQCLNEVVSEWPMLRRCILFTRGETAARMYRKTIGMMEWDGQKAGLIFMERPGPGKRIPQGDGTEKEDKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0SA87</accession>
    <name>G0SA87_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Riboflavin kinase</fullName>
            <ecNumber evidence="4">2.7.1.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Flavin mononucleotide kinase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CTHT_0041380</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>riboflavin + ATP = FMN + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="4"/>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694544.1">
        <property type="nucleotide sequence ID" value="XM_006694481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SA87"/>
    <dbReference type="STRING" id="759272.G0SA87"/>
    <dbReference type="GeneID" id="18258176"/>
    <dbReference type="KEGG" id="cthr:CTHT_0041380"/>
    <dbReference type="eggNOG" id="KOG3110">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048437_3_2_1"/>
    <dbReference type="OMA" id="FDCEVAR"/>
    <dbReference type="OrthoDB" id="276388at2759"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749:SF6">
        <property type="entry name" value="RIBOFLAVIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="RIBOFLAVIN KINASE/FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Riboflavin kinase" evidence="15">
        <location>
            <begin position="17"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGS19659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="230" mass="25595" checksum="94CDA1E0134495F4" modified="2011-10-19" version="1">MSTSARPLLIGPPSGPESPYPFRMSGPVISGFGRGSKELGIPTANLPVDASLIPWITDIPSGVYFGWAALHLDPSHPDYPSKHKLHNGFAVYPMVMSLGYNPFYKNTVRSAEVHILHKFSADFYGRPLRLLITGFVREERDYASLEALVEDILFDCRVARASLARRGWRLKGVSLAVEVKGEGVDGDEKEGEGALDGEWLVRQLDEGELEAGEKWRKEKEEKEKQKGENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0SA95</accession>
    <name>G0SA95_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0041460</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694552.1">
        <property type="nucleotide sequence ID" value="XM_006694489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SA95"/>
    <dbReference type="GeneID" id="18258184"/>
    <dbReference type="KEGG" id="cthr:CTHT_0041460"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027084_0_0_1"/>
    <dbReference type="OMA" id="YTEPATM"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002061">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF20">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G10380)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="237"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="269"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="331"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="389"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="489"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="393"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="455"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS19667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="514" mass="53274" checksum="11E7969D9C21ADD1" modified="2011-10-19" version="1">MSQAPGASDSLGVGTVAIKPEPGMQQVQSVQPGSGPEQVHHVVQPEVQQIQQVPQAQAQPQVQPQPSQPVQHIQQLPIDNKAAPHGSEQKFAAPMNASYTEPATMTSAPMQAVSGTVPATVATTTIPTTLPATVPTTVPTTTTTTTTTTTTTAVPTTLPAAVPSANMAPAPMVHPDFASSVAGGVPQMPFKTEPAAAPAPAPQGPVKAFPCSTCGKPFARRSDLARHERIHSGIRPHVCDYPGCGKQFIQSDSSSLARHRRIHSGQRPYKCPYADCQKTFTRRTTLTRHQNHHVGTVEESARARAEALAQGASAAAAAAAAAAAAAAVAKMQSRPESEQPSVQESPAPSAQSPDQRTVSMSPGAELANMNNMQQFLNNNSIPAHLRSDVHVSSPASTTSSGFNNGMRPTSHPTGYAPQQTAIEPGVDNTQQGPGSAAGSPHIGSVGWASPGPAGSPTQSPNGNTYIYPDPESYPTGTAMGQMFYNNTAATTRRPDSAEPGAGAGRQGELWANAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2023-02-22" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAB6</accession>
    <name>G0SAB6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0041690</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694573.1">
        <property type="nucleotide sequence ID" value="XM_006694510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAB6"/>
    <dbReference type="GeneID" id="18258207"/>
    <dbReference type="KEGG" id="cthr:CTHT_0041690"/>
    <dbReference type="HOGENOM" id="CLU_927500_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="10"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="300" mass="34076" checksum="54251594BF2B47D3" modified="2011-10-19" version="1">MFLTLTLPRLNESRAKVDNLSEILSEKEELLAEKEELIAKQDTELVQAKQDLSNLQAQHNAALGTLGMVNQLMTTSNQTMAMRKDFVNNIRTMLSTFFSYSSRRLRRFTYKLPSTLKEACAELEALRETLGPIVALCDQFSKWGMFDGKKEALKNELEVKQQMHKDGPCTRLEESVCYLKTKAECQYLHAVSKMLDGAVSKKKQELEMVTQELELTKQKLQAQRFSGHKSSLSPLASKSRLVDDPELHSYDHVYLDCAWPMSKSNGRPQRQYFSGCGMKTATNNSHNDDWGCDKDTDAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAL1</accession>
    <name>G0SAL1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein N-terminal and lysine N-methyltransferase EFM7</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongation factor methyltransferase 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EFM7</name>
        <name evidence="6" type="ORF">CTHT_0042670</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha, before also catalyzing the mono- and dimethylation of 'Lys-3'.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM7 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694668.1">
        <property type="nucleotide sequence ID" value="XM_006694605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAL1"/>
    <dbReference type="STRING" id="759272.G0SAL1"/>
    <dbReference type="GeneID" id="18258305"/>
    <dbReference type="KEGG" id="cthr:CTHT_0042670"/>
    <dbReference type="eggNOG" id="KOG2920">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032409_0_0_1"/>
    <dbReference type="OMA" id="VGHNPLW"/>
    <dbReference type="OrthoDB" id="46564at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071885">
        <property type="term" value="F:N-terminal protein N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03223">
        <property type="entry name" value="Methyltr_EFM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025784">
        <property type="entry name" value="EFM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF10">
        <property type="entry name" value="PROTEIN N-TERMINAL AND LYSINE N-METHYLTRANSFERASE EFM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51560">
        <property type="entry name" value="SAM_MT_NNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="82"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS19783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="288" mass="32277" checksum="8237010E18577E38" modified="2011-10-19" version="1">MSDIEADPPLNDLFVEPEGYYPPTPPPTTTFYTTLTGDTITLHLVGHSPLEAHHLWNASRVVAEHFERNPDEVRGRTVLELGAGAGLPSLVASALGAKMVVMTDYPDVDLVRNMWRNVDECALIPREAKKGSQGAEEGDEPTNIVVDGYIWGADTTKLLKYLESDTSSQEPQGFDLLILADLLFRHTEHRNMLKTVRHALKRTRDAKALVVFCSYRPWLQKKDLAFFDLAREQGFEVEKVMEKKMDRPLFENDPGDVEILKTVTGWELRWPETECLGNGEVKANAAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAN3</accession>
    <name>G0SAN3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">NAD-dependent histone deacetylase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0042890</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694690.1">
        <property type="nucleotide sequence ID" value="XM_006694627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAN3"/>
    <dbReference type="STRING" id="759272.G0SAN3"/>
    <dbReference type="GeneID" id="18258327"/>
    <dbReference type="KEGG" id="cthr:CTHT_0042890"/>
    <dbReference type="eggNOG" id="KOG2684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023643_5_3_1"/>
    <dbReference type="OMA" id="PTHEFIR"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046970">
        <property type="term" value="F:histone H4K16 deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF9">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="9">
        <location>
            <begin position="168"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="327"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="524"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="342"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="524"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="539"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="574"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS19805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="586" mass="63863" checksum="ED42A551AF78FB64" modified="2011-10-19" version="1">MGSPRGRSAGSNGTSGSRKPSGRVKNPVDYDEKRRFAELNEQIDGDEQAAIANANMSELDEHLNNLSESWETESLFADAIEDLAEDRFFTEDPEACTPDEAIKYRQLLRALGPEVFCERTIGSGAITAKKLLTAFGIRPPAFLEGCEDDAYYALLSLAFTRELSKRAKLTKYNTVDDAVALLHKCNNIIVLTGAGISTSLGIPDFRSKGTGLYSKLEHLGLNDPQEVFDITVFRQDPSIFYSVARDILPNHDRFTPTHAFIKLLQDKGKLLTNYSQNIDNLEAKAGISRDKLVQCHGSFATATCTKCGRKVPGESIFAQIKAGDIPRCTATPNSGGRKRKLQRDGTEKKPRRRPGDYDSNSDSEFDARSISSAAGGSSGSNNVCNGVMKPDITFFGEPLPDEFGRRLTEHDRDRVDLVIVIGTSLKVAPVSEVVPYLPPHIPQIYISRTPVSHVNFDIDLLGDCDVVVAELCRRAGWELKHEMIPDDQIVEIELAEGYESRHIFTQVHPPPRKVEVATLSIEKEKGVAGKKEDGDTESRSASGSRSASSSAAASPSASGEENGEESSAKEKGKGKGKGRGRRGGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAX6</accession>
    <name>G0SAX6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0048150</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695178.1">
        <property type="nucleotide sequence ID" value="XM_006695115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAX6"/>
    <dbReference type="GeneID" id="18258853"/>
    <dbReference type="KEGG" id="cthr:CTHT_0048150"/>
    <dbReference type="HOGENOM" id="CLU_000680_3_2_1"/>
    <dbReference type="OrthoDB" id="4842715at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="260" mass="28368" checksum="F742A6A8392095F5" modified="2011-10-19" version="1">MAICSADLTLGVFPSAFKRATVVTLSKPGRDPRSYKGWRPISLLSVFGKGIERMVARRMTAAALRAGLLPPEVAGAHSNSLCLGPSSVTYKLCSVLLDQGWPESTSLLAADFCTARSFSFRWARSTFRTDSGLPQGSPWSPILFALFTLPLVRPSQGAAFAYMDDHAQHTWSRDPFQLVYHASLRVAELCEKAQGLGLRIDPRKTDALYIPLRGKGVTKTRTETSKIHVTGGGQDVVPSHSIKWLVVTLDSRLSPKAQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAZ6</accession>
    <name>G0SAZ6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0048350</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695198.1">
        <property type="nucleotide sequence ID" value="XM_006695135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAZ6"/>
    <dbReference type="STRING" id="759272.G0SAZ6"/>
    <dbReference type="GeneID" id="18258873"/>
    <dbReference type="KEGG" id="cthr:CTHT_0048350"/>
    <dbReference type="eggNOG" id="ENOG502SBJ5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112095_0_0_1"/>
    <dbReference type="OMA" id="VHDPNDS"/>
    <dbReference type="OrthoDB" id="274752at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS19376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="183" mass="20784" checksum="53B271E66BC41550" modified="2011-10-19" version="1">MAQAAAAAAQAIKSQVKKLPELHGVVVSAGLMDKTVKVRVGGQKWNNYVKKFFDDPKQYLVHDPCNSLRLGDVVAIEPGWRTSKQKRHVVKYIIAPGSGVPIDQRPPIPTQEERLEEKAAKRYAKVYRRTLRKTAEKVESSLEVAERILRKGWREFEMRKGLIEQAEEKIREREAELAAKVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0SB07</accession>
    <name>G0SB07_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxidation resistance protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0048460</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May be involved in protection from oxidative damage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695209.1">
        <property type="nucleotide sequence ID" value="XM_006695146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SB07"/>
    <dbReference type="STRING" id="759272.G0SB07"/>
    <dbReference type="GeneID" id="18258884"/>
    <dbReference type="KEGG" id="cthr:CTHT_0048460"/>
    <dbReference type="eggNOG" id="KOG2372">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029204_0_1_1"/>
    <dbReference type="OMA" id="DEYNTHR"/>
    <dbReference type="OrthoDB" id="26679at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF62">
        <property type="entry name" value="MUSTARD, ISOFORM V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="7">
        <location>
            <begin position="123"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="65"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS19387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="307" mass="33544" checksum="CB755D377DE10BC4" modified="2011-10-19" version="1">MNLSSSAKHQRPLRSRQSPELGGSSSTPRSTSGACTPTSPGPAPSAFSSFWGGLVRRFSGESTPKYYETSSERHHRRNGTADAVLTKSSRTRTPSPEGGKLTLPPLPPLELVGFAEDTAPSARLLTVQVAEEIRIMVPARLSIVEQWKLVYSLDQDGASLATLYDKCSRYQGKRVGFVLCVRDAGGGLFGAYLSDYPHPAPKYFGTGECFLWRVAVINSRTNDSDEKPPQPEIRFKAFPYSGVNEYYMLCEAHFLSMGAGDGKYGLWLDDSLERGISSRSQTFGNEPLSDEGEKFDVLGVEVWVIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBE1</accession>
    <name>G0SBE1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgi apparatus membrane protein TVP38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Golgi apparatus membrane protein tvp38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0049940</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking and spindle migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695343.1">
        <property type="nucleotide sequence ID" value="XM_006695280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBE1"/>
    <dbReference type="STRING" id="759272.G0SBE1"/>
    <dbReference type="GeneID" id="18259032"/>
    <dbReference type="KEGG" id="cthr:CTHT_0049940"/>
    <dbReference type="eggNOG" id="KOG3140">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_674389_0_0_1"/>
    <dbReference type="OMA" id="VIYHEAI"/>
    <dbReference type="OrthoDB" id="166803at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549:SF2">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="110"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="12">
        <location>
            <begin position="99"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="309"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="310"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS19521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="408" mass="45488" checksum="F5413B253AEE59FA" modified="2011-10-19" version="1">MKDNSEVRVTTRRLSRTLSVRSTNYQPVNWRRLFFAPKYLVWWIIGIIVFVISIFLTVYHHKVVHYLRPWSEKVRDLPAGWVIPIVILIIISFPPLFGHELVALLCGLVYGLWIGFGIVAAGTFLGELGTWFAFTYLFRRRAIKLERTNLNYGALARLTRDGGFWIIFIIRLSAIPSHFSTAVFSTCGVRFWSFALATFLTLPKQIFLVYLGTLLVETDPSGNQNKKEDPTTTIIKDVVFGVVFVVTVVMAGYIYVHMRRVKKVLLAEQEERRIRKEEEALARAAAGSEVVLPLTVNGDDVEVDIEAARSSMSSTRTPQQGSGDPGGLLVQLGGGGSGPNARDGSLSAVVASIRRESGYDPIEQEENRLAVGGNAVPASLAPSRADPLTSPFLWRLYDIQEEVGRDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBH8</accession>
    <name>G0SBH8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0053630</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695699.1">
        <property type="nucleotide sequence ID" value="XM_006695636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBH8"/>
    <dbReference type="GeneID" id="18259401"/>
    <dbReference type="KEGG" id="cthr:CTHT_0053630"/>
    <dbReference type="eggNOG" id="ENOG502SAIV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021051_1_1_1"/>
    <dbReference type="OMA" id="WWGRRWH"/>
    <dbReference type="OrthoDB" id="2796277at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="7">
        <location>
            <begin position="374"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS18754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="478" mass="53006" checksum="497A6EC19CC986DD" modified="2011-10-19" version="1">MTTANLTLGSGTDPAADPTTTTLSIPPDVFYDRQFKAAFETAHASGRLKPLVFPISFLGSVILPVLYLSVPHTTRPWLYRLRWAVAAAVVALNVRLMQTTSAANEAIAYGTGLIAVWGTIWALRMLIFTRPQWEAARIVRVPKGEAEEGREKKVVKADVALDESVAAALEDYDYVWQPYPARAPFLTRLGWSIDLLICFRGAGWNLAISSIPQPPPPSPRLFRSKQPILVQIASIPLHSRTGIFRSQTYASFLRDRLFRMLVSWMVLDVLTITLRKDPYFIFGPEPVPSNNNPFPSILPSDLMAPTVPEFLPNLPLKQYTLPLLRNACALAGIWSGLEFYTSIAQLAFVFLPLLLVPRRLRGAWWPGTDLWANPSLFGNFVSCVLDKGLRGFWSGWWHQTFRAGFLAGPQWALAKGQSKHKHGHGEFDATAVIQILWAFLLSGLLHGAGGHTSSHMDRPAGEAGHGWMWSISDMAARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBW9</accession>
    <name>G0SBW9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein mS38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0055080</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mitochondrion-specific ribosomal protein mS38 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695840.1">
        <property type="nucleotide sequence ID" value="XM_006695777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBW9"/>
    <dbReference type="STRING" id="759272.G0SBW9"/>
    <dbReference type="GeneID" id="18259546"/>
    <dbReference type="KEGG" id="cthr:CTHT_0055080"/>
    <dbReference type="eggNOG" id="ENOG502S2R6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035429_0_1_1"/>
    <dbReference type="OMA" id="PSTHHMS"/>
    <dbReference type="OrthoDB" id="5364404at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013177">
        <property type="entry name" value="Ribosomal_mS38_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32035">
        <property type="entry name" value="AURORA KINASE A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32035:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08213">
        <property type="entry name" value="COX24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01155">
        <property type="entry name" value="DUF1713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein mS38 C-terminal" evidence="6">
        <location>
            <begin position="320"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="43"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="211"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="225"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS18895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="354" mass="40174" checksum="A450CD10B538365C" modified="2011-10-19" version="1">MRPPVTIFPPSVRRALAASATAPQTAALSFTLPYRPATAFQYRRYSSSKPSSPDDGPRDIAARQAVPSSGRSKGEKKQQQPKQVMPQPPSVPSTRHIGDEGLALSTFFALHRPISVTQLLPRTVSDDTFAQIFAPPKSRSNRVAEVLSTLQQTVQDLEEPLSRMNSIANTEQQQAQHHDVVDEHSTKISLKHPDGTETNVYLQLNSIMSGEYLPFHPPPPPEPVAEPEPEPEPEQSTDVEAASESAKEVAEREPRTRVYKAMVTIEETVDSNGEYKVVAHSPELIEEGDEPSRPRTFLERLFERQLRYDEYRRQQGHTMQAISVRRQRKLKMKKKKYKKLMKRTRNLRRKLDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0SC53</accession>
    <name>G0SC53_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Presequence translocated-associated motor subunit PAM17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0055970</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the PAM complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the PAM17 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695924.1">
        <property type="nucleotide sequence ID" value="XM_006695861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SC53"/>
    <dbReference type="STRING" id="759272.G0SC53"/>
    <dbReference type="GeneID" id="18259635"/>
    <dbReference type="KEGG" id="cthr:CTHT_0055970"/>
    <dbReference type="eggNOG" id="ENOG502S1B1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068297_0_1_1"/>
    <dbReference type="OMA" id="MIFGFDP"/>
    <dbReference type="OrthoDB" id="5970083at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013875">
        <property type="entry name" value="Pam17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28021">
        <property type="entry name" value="PRESEQUENCE TRANSLOCATED-ASSOCIATED MOTOR SUBUNIT PAM17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28021:SF1">
        <property type="entry name" value="PRESEQUENCE TRANSLOCATED-ASSOCIATED MOTOR SUBUNIT PAM17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08566">
        <property type="entry name" value="Pam17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="173"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS18979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="269" mass="28845" checksum="B07944C8B20F437C" modified="2011-10-19" version="1">MLPPSTASTMLRASAGRSAGLQPALLRSATCPYSAGLTTMSPFLSTSPPPSKPLQLRLLSTRPTVITYAAAKSLTINISRRHSSTRSQPPRAATPDAEIDAKAAEEAAKAAKAAHPEQVVLDWNTFFQLRKARRRWQSAFSILSSVAGGFGGAAFLSTGMADSVVSQIPLDPLITLGLLTLSCAALGWLVGPSLGTAVFNTLKSKYKGPMAIKESEFFARIKKHRVDPSASSVRNPVPDFYGEKISSVAGYRQWLRDQRAFNKKKEGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCV1</accession>
    <name>G0SCV1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0050310</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695379.1">
        <property type="nucleotide sequence ID" value="XM_006695316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCV1"/>
    <dbReference type="STRING" id="759272.G0SCV1"/>
    <dbReference type="GeneID" id="18259069"/>
    <dbReference type="KEGG" id="cthr:CTHT_0050310"/>
    <dbReference type="eggNOG" id="KOG4534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_511984_0_0_1"/>
    <dbReference type="OMA" id="DQLWVGQ"/>
    <dbReference type="OrthoDB" id="3361892at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032931">
        <property type="term" value="F:histone H3K56 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051236">
        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013178">
        <property type="entry name" value="Histone_AcTrfase_Rtt109/CBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016849">
        <property type="entry name" value="Rtt109"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF2">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE RTT109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08214">
        <property type="entry name" value="HAT_KAT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01250">
        <property type="entry name" value="KAT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51728">
        <property type="entry name" value="RTT109_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="342"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS18434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="511" mass="57333" checksum="ACB965BDCC84BC73" modified="2011-10-19" version="1">MASPTPPSPNPPVNKPGAYDTSLRNRLAAVLPQGHRFGIHHVSTPPTRTEPLCPAPPGERPDKTYRESHFLAVSIHPNAPTISLKRASPGTDDIKQPPPRLPLLAFAIEVFIFTTAYQTILFVSKTDSTGYLHLLGLPKGAPSPIRQVCATFLAYLLDHRKRPNVQSIVNLFARAQDQYLFPGSIRNAGKHVLDDWGLVRWWCRVLNPLMEGLSCEKWANTKGYLIVPGLEETETRSFLPRTPSSLVNWTVGHPLEKISRYVRDFGRVPPRCLIPGYPDDPKSRFRDELDEEVSPRKHSIGAWKSVKTLDQFWEMMAFRQECSSGRLTGFIWLVFDSAASADVHPQPQPLPESSSAAKYKARRKKKKKLSGPIKPREPRIKTVLRNGLLDRPTLTAYYYWPSEGRGDRVVDEAEYKRIIELLLHLDFSTLDKALGSSRRWIHELGAPEVEVIGRATAPEKTEIHAAGITNLTGLVRRMNSKPSDAQLQPRVNVLGANLVRKKKKEESASSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G0SD90</accession>
    <name>G0SD90_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carboxymuconolactone decarboxylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0050930</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695436.1">
        <property type="nucleotide sequence ID" value="XM_006695373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SD90"/>
    <dbReference type="GeneID" id="18259131"/>
    <dbReference type="KEGG" id="cthr:CTHT_0050930"/>
    <dbReference type="eggNOG" id="ENOG502RZ3K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082760_2_0_1"/>
    <dbReference type="OMA" id="RVAVCNK"/>
    <dbReference type="OrthoDB" id="9998495at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846:SF11">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxymuconolactone decarboxylase-like" evidence="1">
        <location>
            <begin position="44"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="192" mass="21430" checksum="A7C49D9A8A13D898" modified="2011-10-19" version="1">MRLPYVPNPPPTANEDEAAIVARIQARRHPRPLQPLDLTLLHAPPVADGWNSFLGAIRTKTTLPDDLRELAISRVAVCNSAWYEWHHHAPLAVKAGVSEAGMAVVKREGALKVEEGVPEGLNEKQWVVVCYTDEMTRNVKVREEMFERVRGLFGEREVVELTATIACYNCVSRFLVALDVGERNNTGPDDTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDQ9</accession>
    <name>G0SDQ9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0052660</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695605.1">
        <property type="nucleotide sequence ID" value="XM_006695542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDQ9"/>
    <dbReference type="GeneID" id="18259304"/>
    <dbReference type="KEGG" id="cthr:CTHT_0052660"/>
    <dbReference type="eggNOG" id="KOG4372">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027968_1_1_1"/>
    <dbReference type="OMA" id="FCTPHVG"/>
    <dbReference type="OrthoDB" id="273452at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF65">
        <property type="entry name" value="ESTERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="DUF676" evidence="5">
        <location>
            <begin position="16"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="357"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="368"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS18660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="472" mass="52971" checksum="9CB23FFA2086E41D" modified="2011-10-19" version="1">MAPLNMEDYMGGAPGAEHLCVLVHGLWGNPKHMASLARALRAQFPPEQVHILVAKRNSGSFTYDGIELGGERVCTEIEEKLELIRSRGERITKLSVVGYSLGGLVARYAIGLLLARGVLDDLECMNFTAFASPFLGVRTPLRGWANHMWNVLGARTLCMSGRQLFGIDRFRDTGKPLLAVLADPNSIFMRALARFRRRTLYANIVNDRSAVYYTTAISATDPYATLFAADSNHVANRVRYLPGYEPIILDPEEPILPPPEQPPENEASPFTMRLSRWAKRVPFVLVLTLLVPVGVVTFLVNSAIQTIRSHRRVKLHESGRAGINVEDYRVNLWFKEMRSAVEGAYEELNSAQENEFLDEGGGTVTPSKGDESLLDADRKQQRENDSEVNPETRPLLSRESTAGGDNLYQTLALAPYQFDAIRALDKLGWRKYPVWIHKHRHSHAAIIVRIEKPAFDEGKVVLKHWVTEEFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDU0</accession>
    <name>G0SDU0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cyclin-dependent protein kinase regulator-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0052980</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695636.1">
        <property type="nucleotide sequence ID" value="XM_006695573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDU0"/>
    <dbReference type="STRING" id="759272.G0SDU0"/>
    <dbReference type="GeneID" id="18259336"/>
    <dbReference type="KEGG" id="cthr:CTHT_0052980"/>
    <dbReference type="eggNOG" id="KOG0653">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020695_9_0_1"/>
    <dbReference type="OMA" id="IQTEIRW"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20568">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20512">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="385"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="7">
        <location>
            <begin position="478"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="482"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="268"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS18691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="639" mass="71020" checksum="F7DC6E4D62F45510" modified="2011-10-19" version="1">MSATGALNAPPKRSAFGDVSNTARGRALDPNSKEAVKTRVKAASAMLAACEIRPNGKENNASTKAGAFSKGNPNKQLQPAAQIKAAPCNNALTQQKAGNGLAQPPIRNGVTKKITAVYNDRQDNNNNNNNNNNNNNNKMGADSEVHLADDLAIVVAKLAKGPRQFKSQPSLRNGQSQQPLRFAQNKLAMEREISTGDEEETGDIDDNVTEAAYEDAVEQLVEECQVDVSRASAQSENMKNHSYNYDYHSTQAVENSRPAKLLPALPITESADRSEDKENHKGQGYPTVRPYQPLGDNTTRNWNAILAPIVDAQAQRELDLAKMYVMQNQTDEEIEEETWDVSMVAEYGEEIFDYMRELEIRLLPNPNYMEIQTEIQWPMRFVLMDWIVHVHHRFCLLPETLFLTVNIVDRFLSVKVVSLGKLQLVGAAALLIAAKYEEINCPSVQEIVYMVDSGYTVDEIVKAERFMLSMLQFELGWPGPMSFLRRISKADDYELETRTLAKYFLEVTVMDHRFVSCPASYLAAGAHCISRLFLEKGGWTPAHVHYSGYTLSQLKPLIQAMYECCIDPHKHHDAVYQKYATAKYKHCSAYVAGKMATGITFSQLFAAATRPSNGPVDDTPKLGLPPAITSTVKPIPLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDU1</accession>
    <name>G0SDU1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial aspartate-glutamate transporter AGC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Aspartate-glutamate carrier 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CTHT_0052990</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Calcium-dependent mitochondrial aspartate and glutamate carrier. Transport of glutamate in mitochondria is required for mitochondrial transamination reactions and ornithine synthesis. Plays also a role in malate-aspartate NADH shuttle, which is critical for growth on acetate and fatty acids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer (via N-terminus).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695637.1">
        <property type="nucleotide sequence ID" value="XM_006695574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDU1"/>
    <dbReference type="STRING" id="759272.G0SDU1"/>
    <dbReference type="GeneID" id="18259337"/>
    <dbReference type="KEGG" id="cthr:CTHT_0052990"/>
    <dbReference type="eggNOG" id="KOG0751">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014931_2_0_1"/>
    <dbReference type="OMA" id="AFQNVMR"/>
    <dbReference type="OrthoDB" id="2161at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015183">
        <property type="term" value="F:L-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043490">
        <property type="term" value="P:malate-aspartate shuttle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000004">
        <property type="entry name" value="Calcium-binding mitochondrial carrier protein Aralar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000552">
        <property type="entry name" value="Probable mitochondrial carrier protein ARALAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051028">
        <property type="entry name" value="Mito_Solute_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678:SF9">
        <property type="entry name" value="CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN ARALAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="102"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="174"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="342"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="440"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="538"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00059916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00082232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGS18692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="698" mass="77892" checksum="9B6E6EC643E615B6" modified="2011-10-19" version="1">MSQVVSVSVKEAVKETLVGSEEPVQLSAQAKARFNRHAVKDPETGELYLGIEQFIDAIAPPNEDYHKIKREQYSILFRVADRTNKGRVTLADYAYFENILNKPDAEYEIAFRLFDVERLGTVKYDDFRRLYELNKGPDSIPFDWDCEWAKLYIGSKAKRHSMDYQQFSQMLRGLQGERVRQAFQHFDTDGDGYIEPEEFARIIRETARHKLSDHLLENLHTLCNIAQGSKVSYANVRAFLNLINEMDLVEMIVRSACSKSSDGKITRAEFLNQAAKTTRFSLFTPMEADVLFHFASLDNPSGRLSLRDFAKVLDASWRRRSDEEAHAVAAEPKRGGALQQTLESAYSFALGSIAGAFGAFMVYPIDLVKTRMQNQRSVNPGQRLYNNSIDCFRKVIRNEGFLGLYSGVLPQLVGVAPEKAIKLTVNDLVRGWFTDKQGKIWWGWEILAGGAAGGCQVVFTNPLEIVKIRLQVQGEVAKSVEGAPKRSAMWIVRNLGLVGLYKGASACLLRDVPFSAIYFPTYNHLKKDFFGESPTKQLGVLQLLAAGAIAGMPAAYFTTPCDVIKTRLQVEARKGETSYTGLRHAAKTIWKEEGFRAFFKGGPARIFRSSPQFGFTLAAYELLQNLLPNPFKPAEAKAVSGDILAPKAAAADSPFYRSRNALKVLLDVNQHFGLASLGPNSQGWKALPGWMGGVTKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDY2</accession>
    <name>G0SDY2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cystathionine beta-synthase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0053420</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695678.1">
        <property type="nucleotide sequence ID" value="XM_006695615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDY2"/>
    <dbReference type="GeneID" id="18259380"/>
    <dbReference type="KEGG" id="cthr:CTHT_0053420"/>
    <dbReference type="eggNOG" id="ENOG502S7T3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105491_0_0_1"/>
    <dbReference type="OMA" id="FESETGP"/>
    <dbReference type="OrthoDB" id="2536440at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42115">
        <property type="entry name" value="BETA-SYNTHASE (BETA-THIONASE), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42115:SF1">
        <property type="entry name" value="BETA-SYNTHASE (BETA-THIONASE), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS18733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="18397" checksum="BF4A22D960E8E67C" modified="2011-10-19" version="1">MTDVISQPTQTFVSKWADRYRGATVEDLDPPAALSLTPSDPISLALLSAFERDYTHLTVVDSKTRSLLGYLSIPHLQTLLSSGRVKPEDEIRTAMIRFRRKGRKYKVITMQTPLEELEAFFEGYETGGQKQDFAVITDEGRRFVLGVATREDLEEFVKRRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0SE18</accession>
    <name>G0SE18_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CP-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0062100</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696526.1">
        <property type="nucleotide sequence ID" value="XM_006696463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SE18"/>
    <dbReference type="STRING" id="759272.G0SE18"/>
    <dbReference type="GeneID" id="18260248"/>
    <dbReference type="KEGG" id="cthr:CTHT_0062100"/>
    <dbReference type="eggNOG" id="KOG1424">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011072_2_0_1"/>
    <dbReference type="OMA" id="VNKADMM"/>
    <dbReference type="OrthoDB" id="61815at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01857">
        <property type="entry name" value="HSR1_MMR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001151">
        <property type="entry name" value="Large subunit GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043358">
        <property type="entry name" value="GNL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709:SF2">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="7">
        <location>
            <begin position="175"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="260"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="616"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="625"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS18195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="647" mass="71615" checksum="FD61BFEAFBB51BE5" modified="2011-10-19" version="1">MVLAKSKKTVGLGNQLMKDRFGKGKGADRKKVSAVTRIDHTTGQEYITNDREEAAWVKMRSITEQDALDEFLATAELAGTDFAAEKMNNVKIIHTDQRNPYLLSAAEERAVLGKQKEHKGRLTVPRRPKWDATTTAEELDRLERQSFLEWRKGLAELQETHDLLMTPFERNLEVWRQLWRVIERSDVVVQIVDARNPLMFRSEDLEEYVKDVDPKKQNLLLINKADMMTYKQRKAWAKYLKGAGIAYRFFSAQLAKESLEAQESEEESEGGPSKAAAQKEEEKVETGAEETSTEASAEKLHDDEEDTKILTVNELEEMLLQYAPEDAGPDRKLQVGLVGYPNVGKSSTINALVGANKVSVSSTPGKTKHFQTIHLSDKVVLCDCPGLVFPNFASTKAELVCNGVLPIDQLREYTGPAALVAQRIPKAYLEAVYGIQIRTRPLEEGGTGIPTGEELLSAYARRRGFMTQGLGQPDQSRAARYILKDYVNGKLVWVQPPPGGPDPTEFNRELYDLSKLPVKRKAAAAAVTSAVQDLALDDDDATSTLGDMIPLPAAGSSKAERLDKAFFKTAQGNAGHMSMPFNYLYSQQGSAQAVAGSKQLSGRKLRTMIALEKGVDPSDVQMATGKKHFKGRGPKGRKKGGRAEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEL0</accession>
    <name>G0SEL0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0064120</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696718.1">
        <property type="nucleotide sequence ID" value="XM_006696655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEL0"/>
    <dbReference type="STRING" id="759272.G0SEL0"/>
    <dbReference type="GeneID" id="18260450"/>
    <dbReference type="KEGG" id="cthr:CTHT_0064120"/>
    <dbReference type="eggNOG" id="KOG3030">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021458_6_1_1"/>
    <dbReference type="OMA" id="WFSYRRY"/>
    <dbReference type="OrthoDB" id="10030083at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000017">
        <property type="entry name" value="Diacylglycerol pyrophosphate phosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF35">
        <property type="entry name" value="RE23632P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="85"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS18387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="299" mass="33642" checksum="73C7CCC128DCCFA9" modified="2011-10-19" version="1">MERSYASDYIGFISLFLGYTYLVFTARPFHRLFTLHDTRISFPHAEHERVPLGQALLYSLATPMIVMTIVNLLRRAPARNHHLSLMPFLLAMILTPFVTEVIKNAVGRPRPDLLARCIPAKGTPTDKLVGIEVCTQDDDFILQDGWRSFPSGHSSFAFCGLGYLSLWLCGQAKVFVLRQKGEERSAVVVRGDFIKAMVCGSPLIGAILIAVSRTQDYRHDVWDVSVGALLGFAIGWWSYRRYWPRLTSPYCNEPYAAPLPIEEAAAAARYGRVRDEEEAVSLGRGEDRNVGFELNEIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEM9</accession>
    <name>G0SEM9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dynactin subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0064320</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696737.1">
        <property type="nucleotide sequence ID" value="XM_006696674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEM9"/>
    <dbReference type="STRING" id="759272.G0SEM9"/>
    <dbReference type="GeneID" id="18260470"/>
    <dbReference type="KEGG" id="cthr:CTHT_0064320"/>
    <dbReference type="eggNOG" id="KOG3121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088622_0_0_1"/>
    <dbReference type="OMA" id="SQIHGTQ"/>
    <dbReference type="OrthoDB" id="417208at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03359">
        <property type="entry name" value="LbH_Dynactin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047125">
        <property type="entry name" value="DCTN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126:SF1">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21711">
        <property type="entry name" value="DCTN5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS18406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="198" mass="21079" checksum="6FAD78B523A18BD2" modified="2011-10-19" version="1">MSSRRVPRGEYIETDTGNKVARKATLVGTQNIMLGGKTVIQPEAMIRGDLVRTIQAPAPASGAPPNNTAVSIGRYCFLSKGCCLRPPGRPYKGAFTYMPLRMGDHVYVGPGAVIQAASIGSHVHIGAKVVVGEFAIIKDYVRVLDGAVIPPNMVIPSFSIVAGQPARVIGEVPEGMLESFELRDLYKTVGNNPQPPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEP6</accession>
    <name>G0SEP6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Importin beta-4 subunit-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0064500</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696754.1">
        <property type="nucleotide sequence ID" value="XM_006696691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEP6"/>
    <dbReference type="STRING" id="759272.G0SEP6"/>
    <dbReference type="GeneID" id="18260488"/>
    <dbReference type="KEGG" id="cthr:CTHT_0064500"/>
    <dbReference type="eggNOG" id="KOG2171">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003794_1_1_1"/>
    <dbReference type="OMA" id="ANACGCV"/>
    <dbReference type="OrthoDB" id="7862313at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="24"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="8">
        <location>
            <begin position="386"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="8">
        <location>
            <begin position="481"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS18423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1098" mass="121089" checksum="07B8F2249DE044D6" modified="2011-10-19" version="1">MDKQRLAALLQESQVPNTKNLKAVTSELQKNYYSHPESLLLLIEIVATHEDLNVRHQAAVQAARLAVKHWERIPKEQKNAVRQHLVQATMNEQTLRTRHANARLLASIATIDLEEGEWADLIPALFNLATSNEVAQREVGSYIIYSILEENPVAFGDHIAQLLELFSHTLRDPQSADVRINSMMSIGSMLMLFEPLEEEEQVKALQSLIPSMVEVLKDAVQGGDDEKTNQAFEVFQQFLAYESALLGKYLKDLVQFMIDLAANTQAEDDVRSQALSFLAQTVRYRRIKIQGMKDMGKELTLKSLLILTEIGDVEDEDDMSPARAALALLDQLATDLPPRQVIVPLLDALPKFATSSEAGYRKAGILALGTVCEGAPEFISSQIKGIMPVALNLLNDADIGVRHTALIGIARLSEDLAEEISEYNEPVMAALVKNLQAATEPTVDPKLAKKNIEIIRSVCGALDAMSDGFDSEFLKKYSHELVSNIGSLISHEDYKVKVAASGAIGAIAEALGEDFKPYFEETMRALGPYLAVKETEEDLALRSGVCDSIGRIAAAVGPQAFQPYVVDLMRSSEEALHLDNTRLRESSFILWSSLAKVYEKEFAPFLEGVFTGLFQSLELEEEEIKLTLSEDEKGIVGTEEEVITGGKKLKIKNAVADEEDWMDDDSDDDDYEDFGISAEALEKEVAIEILGDIITYACGPDDIARYLEKAVESVSNLVDHSYEGCRKAAIATLWRSYARVWQLMEQETGTSWEPGLPLKQTPTVTLVKLGEIVSKATLSLWHEETDRSVVTEINRNIAATLKACGPAILAQSDMLKESITAVTTMITRAHPCQQDLGDEEEEQTVEGTSEYDWLVIDTALDVIIGLAVALGPGFSELWKIFEKPLLKFASSESENIERSTAVGVIAECTANMKAAVTPYTEKLLKILLKRLSDTDLETRSNAAYATGQLIFNSTDSNTYLPHFSTILGKLEPMLQLEGARIKDNAAGCISRMIMAQPTVLPLGEILPVLVSLLPLKEDYEENTPVYACLFKLLEAQEPTIQQLAPKLVPVLESVLNPPEDQLSDEARDNVRKIVALLFNANQALFANHPNAVKLAGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEX6</accession>
    <name>G0SEX6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0060050</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS17992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696323.1">
        <property type="nucleotide sequence ID" value="XM_006696260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEX6"/>
    <dbReference type="GeneID" id="18260043"/>
    <dbReference type="KEGG" id="cthr:CTHT_0060050"/>
    <dbReference type="eggNOG" id="ENOG502RZ72">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035633_2_0_1"/>
    <dbReference type="OMA" id="HRMITKM"/>
    <dbReference type="OrthoDB" id="5360701at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="416" mass="45780" checksum="B0D5D0AC4DB422D2" modified="2011-10-19" version="1">MRPSHPASGLRLCRTCELLLRPQSQAARRQLPRCSTSIRPFTTTPPSLKKRAEPSAAANTSQSRFGRIQKAAGEQPPDVDPTVYSLAAIDRVLRDFFSPGGVPSEQMTVAALRALTPVDLKLVKEPKKAEEQAKIKLSHHQPAEDLLEAGRTTQPQHTSHKPSIIIDKISEAAYSIVTHPDTIITRNVLEEYVRLQSRLGRPESLPQVLNLFASKPKPKVSSGAVTYVERNPESAENSIDPAIADMALDAAIEAKDLQTTIGVLENTYSSKAFLRAKLLKKALLPGFAMAGTPVALYLVAGELAKYQTALEPKVATGIAFIGGLCYVGFTATIGMVAHFSRNDQMIRVTWAPGTPLRHRWLHEEERAALDKIVCAFGFSEETRFGEEEGEDWEWLREYCLSKSMIVDAVELMPGMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFA6</accession>
    <name>G0SFA6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dolichol kinase</fullName>
            <ecNumber evidence="3">2.7.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0061370</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polyprenol kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.108" evidence="3"/>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696453.1">
        <property type="nucleotide sequence ID" value="XM_006696390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFA6"/>
    <dbReference type="STRING" id="759272.G0SFA6"/>
    <dbReference type="GeneID" id="18260175"/>
    <dbReference type="KEGG" id="cthr:CTHT_0061370"/>
    <dbReference type="eggNOG" id="KOG2468">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007859_0_0_1"/>
    <dbReference type="OMA" id="HGTMVAM"/>
    <dbReference type="OrthoDB" id="377083at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004168">
        <property type="term" value="F:dolichol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043048">
        <property type="term" value="P:dolichyl monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032974">
        <property type="entry name" value="Polypren_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205:SF15">
        <property type="entry name" value="DOLICHOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="314"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="479"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="575"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="615"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="679"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="722"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="761"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="107"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS18122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="867" mass="94931" checksum="2B2FFBD870F39F4B" modified="2011-10-19" version="1">MTDDRTSSVTSSSSTDSSPALPATDAPPERIPSRSSQPYHRGSFSNITMPQFARESFMPSESGTEADDEHVPKGLPVPRSRHHGKSVLALGGKAEVVSESSTSVLSPDVLEEEGRVRKKQNGGMDRERKRVGDRGRRRRELVRRAVEVGLLGFQAAMVAANPDAEGVIRTYWRELLSVGNLWCVLIALYPLRLVCWAYRQGKLSRTIPIRIPASFDLAPMLYPQIIPVLISLLVAHNLQGVVLPSLVLSISALPRPLIPTARPWETFSNMQWLLSCLPFSLHKLGFGSPHDGEQEIAPEILALLYPLHQTLCLILLYLTTTSLLVSEVHLLSIGLIHLLLFARSPQAVILRAILWGGGLGLLVSCSHVIRWGITLARIPKWRFRKAPSDEPALAELFRELLSLLRPRTSSKTSRLNLESDYSTDEDEILLSHPAHTCPVPDRPPSNHATTPSGRRKRAPSASLRAFFSLTYEQSVTRRWLYAGYVYACTLVIAFLVVRPHIQTYALGGREPLGWAVGYFLGDWPQFRFWAVKGNWERWISLPPLRDDIEKGLLCEGTGWVNRLRMTFLGPAHTRLAISAYYLILITFALSLLLLHLARKSVCGSDVDTRRKVFHFLTVFMFLPTLYIDPTFVALAMAVVLGIFLLLDLLRASQLPPLSKPIAHFVEPFVDGRDLRGPVVVSHIFLLVGCAVPVWLSLASLPRSASNNEEDPWKGWELSSREVALVAGVVCVGLGDAAASLVGRRWGKTKWLWGGGKSVEGSVAFAVAVLIGLLAGAAWLRVGGWPTAVPGIADLGSGGGSGMESLRSVLDVKRLWGWLGPGPEGTGVLGKATACATVASLTEAVLTGGNDNVVVPVVLWECVKALAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFJ0</accession>
    <name>G0SFJ0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF7137 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0071010</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697373.1">
        <property type="nucleotide sequence ID" value="XM_006697310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFJ0"/>
    <dbReference type="STRING" id="759272.G0SFJ0"/>
    <dbReference type="GeneID" id="18261139"/>
    <dbReference type="KEGG" id="cthr:CTHT_0071010"/>
    <dbReference type="eggNOG" id="ENOG502S1TN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058864_0_0_1"/>
    <dbReference type="OMA" id="WGWNYTN"/>
    <dbReference type="OrthoDB" id="2435509at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055561">
        <property type="entry name" value="DUF7137"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42028">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42028:SF1">
        <property type="entry name" value="YALI0E30657P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23585">
        <property type="entry name" value="DUF7137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409110" description="DUF7137 domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7137" evidence="4">
        <location>
            <begin position="117"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS17755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="292" mass="31790" checksum="5C58BE9599200FEA" modified="2011-10-19" version="1">MKAHFTLGQLAVVLLSLSHAANALSWPRWLPDIDTLIVRQEDDSKETSPTPTAKPTSAKDDPDDTEDKPTTSRNPFEPITTNLNTGGLTKSATATGKVTGNTTTTRPPRKTQFNPMDPAGSVVMLTPAPTEAFPLYKIGDYITWGWNYTNLQATPTAIDLYVKCSKVPQPWTLTQNMTWATKGEYTWDTKAFQTEHVENPLLTEQYTLVIADAETGPSATPEAGYLAPFSGFHFGLYKPMDYQDSADGWTCASCSGARRATGVDVKGLGMALGMCVVTVVSFTWFVVGIGMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFK5</accession>
    <name>G0SFK5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Scytalone dehydratase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0071160</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the scytalone dehydratase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697388.1">
        <property type="nucleotide sequence ID" value="XM_006697325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFK5"/>
    <dbReference type="STRING" id="759272.G0SFK5"/>
    <dbReference type="GeneID" id="18261154"/>
    <dbReference type="KEGG" id="cthr:CTHT_0071160"/>
    <dbReference type="eggNOG" id="ENOG502SNND">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101889_0_0_1"/>
    <dbReference type="OMA" id="SACYEWA"/>
    <dbReference type="OrthoDB" id="5281072at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030411">
        <property type="term" value="F:scytalone dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006582">
        <property type="term" value="P:melanin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004235">
        <property type="entry name" value="Scytalone_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049884">
        <property type="entry name" value="Scytalone_dh"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02982">
        <property type="entry name" value="Scytalone_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF024851">
        <property type="entry name" value="SCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scytalone dehydratase-like" evidence="6">
        <location>
            <begin position="8"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR024851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR024851-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR024851-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS17770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="171" mass="19995" checksum="E0D9A43F31FF4D67" modified="2011-10-19" version="1">MSSEKKQISFEEYLGCTEAAFEWADSYDSKDWDRLRKCIAPTLRIDYRSFLNKLWEAMPAEEFIQMISSPTVLGNPLLRTQHFIGGASKWEKVSDTEIIGYHQLRVPHQVYTDSSLSQVKVKGHAHSHNTHYYRKVDGVWKFAGLCPDIRWFEYDFDKVFESGRESFGEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0SG32</accession>
    <name>G0SG32_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0064860</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696789.1">
        <property type="nucleotide sequence ID" value="XM_006696726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SG32"/>
    <dbReference type="GeneID" id="18260524"/>
    <dbReference type="KEGG" id="cthr:CTHT_0064860"/>
    <dbReference type="eggNOG" id="ENOG502SMK9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_25_4_1"/>
    <dbReference type="OMA" id="HIWDFKF"/>
    <dbReference type="OrthoDB" id="3934549at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF129">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="44"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS17171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="370" mass="40796" checksum="7AE2B52A632C64BB" modified="2011-10-19" version="1">MRLPPPEVMATWPKPNYVNPETRGSTLIVVEILTLFLAVTCVALRLYVRIVMMRKTDWDDWLMVGASIFGAGITACVILAVTRYGWNIHVWDLTPMKMVSGRQVSLAAQAIFVGATCLAKTSILLSYLRLAPAKSLFRRLTIATIWFVILNNIAFFVVLFTQCIPLSSYWNLGPNHADDCLSEGSALIAHASFTVASDLLVWVLPLPALYQAKLPFSQRIALIVLFSFGLVVVVAACLRTYWIHHVVNETYDVTWEGFQLWMWTAIEVHLGIICGCVPWLKSLFRFWRAKKTGTSVSAMSGAMSGASAGGTGRRTRSKSDIRPVGSATVCVEGAVFKMDTLGKPPVNKEAYLDLESCAASHTTRDESNPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGE7</accession>
    <name>G0SGE7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative translation initiation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0066060</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17286.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006696841.1"/>
    </dbReference>
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    <dbReference type="STRING" id="759272.G0SGE7"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OMA" id="LPLQYHW"/>
    <dbReference type="OrthoDB" id="17977at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Translation initiation factor eIF4E, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF66">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="240"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="251"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGS17286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="291" mass="33233" checksum="6AC1200D9F8883D3" modified="2011-10-19" version="1">MSMRPTLFTRGLSGLSQSTDANSPSVASPAEQRDDAKRNFLKAMRPLPTQHYWHVWFDRQRDNQQQQQQQQQSGPGGQQTQSSGEYTAHLEQLPGRIESVQDFWRYHNNTPIDQIKMRESIYLFKAGFRPVWEDRRNVLGGAWTFRVPKSIGPDVWTRVQLLAVGEKLQSVLEEGDQICGVGLSVRFNSHLISIWHRDSSRKKSIDNMLQCVLEELPPELRPRPDNYFYKRHADHAGFKAPPELQAVIDSQRAREAAEAKAAAEKEAQEKASKQEQQEQQQEEKADGANGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGJ7</accession>
    <name>G0SGJ7_CHATD</name>
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        <submittedName>
            <fullName evidence="3">Putative N-terminal asparagine protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0066570</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006696891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGJ7"/>
    <dbReference type="STRING" id="759272.G0SGJ7"/>
    <dbReference type="GeneID" id="18260695"/>
    <dbReference type="KEGG" id="cthr:CTHT_0066570"/>
    <dbReference type="eggNOG" id="KOG0806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009854_0_2_1"/>
    <dbReference type="OMA" id="CFESECT"/>
    <dbReference type="OrthoDB" id="201515at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008418">
        <property type="term" value="F:protein-N-terminal asparagine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070773">
        <property type="term" value="F:protein-N-terminal glutamine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07566">
        <property type="entry name" value="ScNTA1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039703">
        <property type="entry name" value="Nta1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11750">
        <property type="entry name" value="PROTEIN N-TERMINAL AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11750:SF26">
        <property type="entry name" value="PROTEIN N-TERMINAL AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="423" mass="47048" checksum="52A6BBFB2260198D" modified="2011-10-19" version="1">MRIGCLQFAPRVGEFESNKSRAEAILARADPEDLQSLDLLVLPEMALSGYNFKSREHIEPHLEPTTAGPSAQWAREKAREYGCTVAVGYPEKVEGFEREYYNSLVVVNSQGETLANYRKSFLYYTDETWAREGQGFFRGPLGNFGQVAMGICMDINPYKFEAPWDAYEFGFHVQRLRPNLVILSMAWLTNDDRTKFLSMPDKPDLSTLSYWVQRLTPVLHDKSGDETIVVFSNRCGIEDDATYAGTSTVLGIKNGEVVIYGILGRNVEELLVVDTRDLPMGELVTRSTTSVEDEDSEAEETNHRPGAEPRRPSANSEGSGRGVDSPTLPPSNSRSSAGGHTHATAQQANMNINGQRNLETPSPRSNALSARPKLSARKHELMVFPSTGLTAALVKGRKPFIGFRAPPYRRGRRHSDCFESECT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGP3</accession>
    <name>G0SGP3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">60S acidic ribosomal protein P0</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0067070</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="476" last="476">
            <title>High-resolution structures of a thermophilic eukaryotic 80S ribosome reveal atomistic details of translocation.</title>
            <authorList>
                <person name="Kisonaite M."/>
                <person name="Wild K."/>
                <person name="Lapouge K."/>
                <person name="Ruppert T."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="35079002"/>
            <dbReference type="DOI" id="10.1038/s41467-022-27967-9"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.90 ANGSTROMS)</scope>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2023" name="Nat. Struct. Mol. Biol." volume="30" first="670" last="677">
            <title>Structural inventory of cotranslational protein folding by the eukaryotic RAC complex.</title>
            <authorList>
                <person name="Kisonaite M."/>
                <person name="Wild K."/>
                <person name="Lapouge K."/>
                <person name="Gese G.V."/>
                <person name="Kellner N."/>
                <person name="Hurt E."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="37081320"/>
            <dbReference type="DOI" id="10.1038/s41594-023-00973-1"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.20 ANGSTROMS)</scope>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2024" name="Nat. Commun." volume="15" first="716" last="716">
            <title>Methionine aminopeptidase 2 and its autoproteolysis product have different binding sites on the ribosome.</title>
            <authorList>
                <person name="Klein M.A."/>
                <person name="Wild K."/>
                <person name="Kisonaite M."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="38267453"/>
            <dbReference type="DOI" id="10.1038/s41467-024-44862-7"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.10 ANGSTROMS)</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. uL10 forms part of the P stalk that participates in recruiting G proteins to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EGS17382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_006696937.1"/>
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    <dbReference type="PDB" id="7OLC">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="Ls=1-312"/>
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    <dbReference type="PDB" id="7OLD">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="Ls=1-312"/>
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    <dbReference type="PDB" id="7Z3N">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.20 A"/>
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    <dbReference type="PDB" id="7Z3O">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.30 A"/>
        <property type="chains" value="Ls=1-312"/>
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    <dbReference type="PDB" id="8OO0">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="Ls=1-312"/>
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    <dbReference type="AlphaFoldDB" id="G0SGP3"/>
    <dbReference type="EMDB" id="EMD-12976"/>
    <dbReference type="EMDB" id="EMD-12977"/>
    <dbReference type="EMDB" id="EMD-14479"/>
    <dbReference type="EMDB" id="EMD-14480"/>
    <dbReference type="EMDB" id="EMD-17004"/>
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    <dbReference type="GeneID" id="18260745"/>
    <dbReference type="KEGG" id="cthr:CTHT_0067070"/>
    <dbReference type="eggNOG" id="KOG0815">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053173_1_1_1"/>
    <dbReference type="OMA" id="DMNPFKL"/>
    <dbReference type="OrthoDB" id="10259902at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05795">
        <property type="entry name" value="Ribosomal_P0_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050323">
        <property type="entry name" value="Ribosomal_protein_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030670">
        <property type="entry name" value="uL10_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039087">
        <property type="entry name" value="L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="10 11 12" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="7">
        <location>
            <begin position="109"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="279"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR039087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS17382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="7OLC"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="7OLD"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="7Z3N"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="7Z3O"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="8OO0"/>
        </source>
    </evidence>
    <sequence length="312" mass="33817" checksum="4DE937C77362F8BA" modified="2011-10-19" version="1">MGGKSGNKAGYFDKLKGLLEEYPSIFVVSVDNVSSQQMHEIRKALRGQGVVLMGKNTMVRRALKTFMPDHPEYERLLPFVKGNVGFVFTNGDLKEVREKILSNRIKAPARAGAIAPVDVWVPAGNTGMEPGKTSFFQALGIPTKIARGTIEITTDIKLVEAGAKVGPSEATLLNMLNISPFTYGMGIAQVYDQGNTFPASVLDVSEEQLLKSFTSAITTVASLSLALNYPTLPSVIHSLINSYKKVLAVAVETEYSWPEIEELKDRIANPEAYAVAAPAAAAAAPVEEKKEEKKEESEKEESDDEGFGGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGX4</accession>
    <name>G0SGX4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Malate dehydrogenase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0067900</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697081.1">
        <property type="nucleotide sequence ID" value="XM_006697018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGX4"/>
    <dbReference type="GeneID" id="18260828"/>
    <dbReference type="KEGG" id="cthr:CTHT_0067900"/>
    <dbReference type="eggNOG" id="ENOG502S85Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067863_0_0_1"/>
    <dbReference type="OMA" id="STCAGQN"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021706">
        <property type="entry name" value="DUF2990"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021851">
        <property type="entry name" value="DUF3455"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567:SF1">
        <property type="entry name" value="CONSERVED FUNGAL PROTEIN (AFU_ORTHOLOGUE AFUA_1G14230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567">
        <property type="entry name" value="MALATE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G13800)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11693">
        <property type="entry name" value="DUF2990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11937">
        <property type="entry name" value="DUF3455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409233" description="Malate dehydrogenase-like protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="27696" checksum="5ACF67BAEF48A577" modified="2011-10-19" version="1">MRFSLVASTLATCAWAAPPFPRINVLDTIPNNIRAISDYFNLLATKVQESKKLAAPPACDLSQVSLPEYARSSLPPPSPGLVLKHIAIGRGTQNYTCDPGAEKPRQTGAVATLFNASCTVATSPELASLLGHAALQFPLHQSLETQRLAPSNLAVSGVHFFTKDGAPWFDLDVSPLWKMGGIVGAKNTSAQAPETAAKGLGGEPAVPWLKLVAKESTGGLQEVYRIETVGGSAPQTCSGMPIGREFQVEYATQYWFYAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G0SH15</accession>
    <name>G0SH15_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Heat shock protein hsp90-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0068330</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697122.1">
        <property type="nucleotide sequence ID" value="XM_006697059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SH15"/>
    <dbReference type="STRING" id="759272.G0SH15"/>
    <dbReference type="GeneID" id="18260871"/>
    <dbReference type="KEGG" id="cthr:CTHT_0068330"/>
    <dbReference type="eggNOG" id="KOG0019">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006684_1_3_1"/>
    <dbReference type="OMA" id="MRRMKEM"/>
    <dbReference type="OrthoDB" id="28737at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.790:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.80:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11260:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000001">
        <property type="entry name" value="Heat shock protein HSP 90-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="9">
        <location>
            <begin position="27"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="213"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="683"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="218"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="686"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="100"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="120"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS17504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="709" mass="80562" checksum="2FBED08BDF0856B9" modified="2011-10-19" version="1">MAQAETFEFQAEISQLLSLIINTVYSNKEIFLRELVSNASDALDKIRYESLSDPSKLDTGKDLRIDIIPDKENKTLTIRDTGIGMTKADLVNNLGTIARSGTKQFMEALSAGADISMIGQFGVGFYSAYLVADKVTVVSKHNDDEQYIWESSAGGTFNIIPDVNGEPLGRGTKIILHLKDEQTDYLNESRIKEVIKKHSEFISYPIYLHVKKETEKEVPDEEAEEKAEEKTEEGDDKKPKIEEVEDDEDKKKEKPKKTKKVKETKIEEEELNKQKPIWTRNPQDITQEEYASFYKSLSNDWEDHLAVKHFSVEGQLEFRAILFVPKRAPFDLFETKKTKNNIKLYVRRVFITDDATDLIPEWLGFIKGVVDSEDLPLNLSRETLQQNKIMKVIKKNIVKKSLELFNEIAEDKEQFDKFYSAFSKNIKLGIHEDSQNRAALAKLLRFHSTKSGDEMTSLTDYVTRMQEHQKNIYYITGESIKAVAKSPFLDLLKEKNFEVLYLVDPIDEYAMTQLKEFEGKKLVDITKDFEIEETEEEKKKREEEKKEFEGLAKSLKNILGDKVEKVVVSHKLIGSPCAIRTGQFGWSANMERIMKAQALRDTSMSSYMASKKTFEISPKSPIIKALKTKVEAEGENDKTVKSIVQLLFETSLLVSGFTIEEPASFAERIHKLVSLGLNLDEETEASTEAAADAGASAAETGDSAMEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0SH18</accession>
    <name>G0SH18_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0068360</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697125.1">
        <property type="nucleotide sequence ID" value="XM_006697062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SH18"/>
    <dbReference type="STRING" id="759272.G0SH18"/>
    <dbReference type="GeneID" id="18260874"/>
    <dbReference type="KEGG" id="cthr:CTHT_0068360"/>
    <dbReference type="eggNOG" id="KOG2217">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_457824_0_0_1"/>
    <dbReference type="OMA" id="PPDIDPY"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000073">
        <property type="entry name" value="DnaJ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051187">
        <property type="entry name" value="Pre-mRNA_3'-end_processing_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13484">
        <property type="entry name" value="FIP1-LIKE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13484:SF0">
        <property type="entry name" value="PRE-MRNA 3'-END-PROCESSING FACTOR FIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="655" mass="76691" checksum="C6704BCE4156599A" modified="2011-10-19" version="1">MTSTLPPDPWKALGVDRNADKAEIRAAYKKLVLKCHPDKVQDPALKAQKQDEFQRVQQAYELLNDDAEKAKYEQKLKLAELLQQRAAKMQQDVKNAPNSSVPRSAPKYSTCDFRTPDPSKYKPHPSPTNGKVYTHSSGAHTRSAEEMSRSYYDESDRQARRTASYEKPSKRDEEKREKEERKRRKEEEEIKDRVREKEREREREKERERDKEDREKEREREREKEKEKDKDREREKEKEREREKEKEKEKERERDREREKDKEKERDREREREREREKDREKEKTAKRNESGTRIGKGKDPGRGRKTAKPEKQRGRRPIRLERRNESRIQTRLTESEKKRSSTKKKHDEKDRDRERERERERERDRDRERRERDKSSSRRPKSDYPAEDTKYESTFEQAASYIATLSGSSPSRTFWSSQQTSSTAPHPNSANPVPACPTPPPPGADFEEESIQQAAARAAAGRRPSHESRSRDKIRYDTMDSRGIPILTKSHTVHTPIVESPPRVSRSGATSQDYMSSSYTKSSIPPLGRTQTWAPGSAGAASADYDYGVFDGPDYDSEEDRDREHNRRRRRGSSNRYAHPQYAYGGSPASTRSSRYDVIDGASHSTSGTYMGATFKVRESRKIRPEDISYAQHDPPSYYWPPTEGYHDGPYVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHB9</accession>
    <name>G0SHB9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Endonuclease</fullName>
            <ecNumber evidence="17">3.1.30.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CTHT_0069470</name>
    </gene>
    <organism evidence="23">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2 17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the DNA/RNA non-specific endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="3.1.30.-" evidence="17"/>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697226.1">
        <property type="nucleotide sequence ID" value="XM_006697163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHB9"/>
    <dbReference type="STRING" id="759272.G0SHB9"/>
    <dbReference type="GeneID" id="18260985"/>
    <dbReference type="KEGG" id="cthr:CTHT_0069470"/>
    <dbReference type="eggNOG" id="KOG3721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055174_0_2_1"/>
    <dbReference type="OMA" id="YVMPNQV"/>
    <dbReference type="OrthoDB" id="5418055at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00091">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.570.10:FF:000004">
        <property type="entry name" value="Nuclease 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018524">
        <property type="entry name" value="DNA/RNA_endonuclease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="ENPP1-3/EXOG-like_nuc-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040255">
        <property type="entry name" value="Non-specific_endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966:SF5">
        <property type="entry name" value="ENDONUCLEASE G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966">
        <property type="entry name" value="ENDONUCLEASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01070">
        <property type="entry name" value="NUCLEASE_NON_SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 17" id="KW-0540">Nuclease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409563" description="Endonuclease" evidence="19">
        <location>
            <begin position="19"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="21">
        <location>
            <begin position="107"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="ENPP1-3/EXOG-like endonuclease/phosphodiesterase" evidence="20">
        <location>
            <begin position="108"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="45"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU366055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EGS17608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="350" mass="38597" checksum="A56F4D28A1A0C871" modified="2011-10-19" version="1">MSKATLAVIAAVSAGAGAAATAAMYSLRGDGSNNNNKKKLESTAAPIAPSSTLAPRLTSSPVTVPVPASQVFDNSPSTPSNTPSNAPVDPSGLFQYGFPGPISDLATRQAFISCYDRRTRNPHWVAEHITPQSLAIRDGDRKNSNFLEDPLIPAKFQAKLKDYFRSGYDRGHQVPAADCKWSQSAMDETFYLTNMCPQVGDGFNRDYWAHFEDFCRRLTEKYPSVRIVTGPLYLPKRDDKDGKWYVKYEVIGNPPNVAVPTHFYKVIYAEEDGPEKKVALGAFVLPNAVIPNEKPLQDFEVPLEAVERATGLEFASKLPVQRRKRLCAETSCSIIVKEYAERQKAFAKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0SI46</accession>
    <name>G0SI46_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0074460</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697698.1">
        <property type="nucleotide sequence ID" value="XM_006697635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SI46"/>
    <dbReference type="STRING" id="759272.G0SI46"/>
    <dbReference type="GeneID" id="18261484"/>
    <dbReference type="KEGG" id="cthr:CTHT_0074460"/>
    <dbReference type="eggNOG" id="ENOG502S03E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_248424_0_0_1"/>
    <dbReference type="OMA" id="QWQTEWT"/>
    <dbReference type="OrthoDB" id="4115400at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460:SF0">
        <property type="entry name" value="CID DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="428"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="656"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="977"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="554"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="201"/>
            <end position="217"/>
        </location>
    </feature>
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        <location>
            <begin position="250"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="466"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="480"/>
            <end position="495"/>
        </location>
    </feature>
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        <location>
            <begin position="666"/>
            <end position="688"/>
        </location>
    </feature>
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        <location>
            <begin position="765"/>
            <end position="778"/>
        </location>
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        <location>
            <begin position="840"/>
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        </location>
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        <location>
            <begin position="935"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="977"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="997"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1018"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1062"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1088"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1119"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1134"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1233"/>
            <end position="1247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1247" mass="135004" checksum="8167D2A5954F7521" modified="2011-10-19" version="1">MHSAVLPAPSTRKRSRALIETPQDATVEEEGHSKGGHSLRKRARIDYTQEVIDDEVGVAITKTAAATPTTRSRKRRGAADDSEEESDREEFSSANKRRRAEGSPAPMGRTAGSYRRRQPSASKKPATEVAPALAASVVGQLADDVQDTILVGVPMDDTGAESTQSSPQKTDSRSDSSIRSADKDAGRTKETSPAPQQELDASWGTSAASSATLASNSPVDETKVTQEQRLTIEPPAAAAAAKDSPRPSEPKASPSPSAESAPRPTTENAAASGQPAPEAKPSEGSAAAPAAQAEVSSPLLRRAAKSTGPARMRALEPIYSSPTPFGTLLKLTPYESEDIALPGPFTEWVYPAADKAKAVEPTPVVTPTAASVSTEPKPVVSWDARRPLKVSEFFNLWRQEKKRREEAGEPPISLVEFNNVCAKRYREAQKNLDQPGGISPADEEEEVPAPKKSATKRKDVEESVQDDSQAPTAAPSPAAAEDEANQEDAVDEEQDTATVSNSPALKPDSPVEPIEVTRLPRKQYLFPKLRDPNEFVEALENYQEMDSDKLYSTLAAAVETMDVYQREYNELRKILDDEDNAKRRQANDKTIVNWENRQKADDPPHWRRHFDDVVKGPTPYEIRGVRAPKPYVDDPVLEHQREEDRLMAQIYGFKHNNHPSMVGRQNPEEQRWEMPENRLRKRTEKGAELAEDNVIEGKRTRKPRYVNESKDVSRAGTPLPSLPWGRRQRRKRIATPLDGEGEEADAPAENVEQPVRKGRRGRPPASAVAAATAAAQAQADRDDQESVMAEAQDANQTEDENEVETKPKGRRRGRIAAAKQEAPTSVPAGFGKRGRGANAGQETLYGQTVEQQQESRPSTASSEHTNDTVESTYSLREKKRRNFALENDPEIEPRRRGRGTVKQDTNSENNGEPRRRQRRKEPAAQDQPEVPMHPQHQQLAQTAAQSAPGSPHLQPIAASKFYHSFMTGPMVVEHMPQQAAHQPAQGPYLHTFNASPAFPPGVTPPPPPPPSVKKPITKIKITNPPGQTGNGTSNGSASASGSTSRAQTPANGTGGKGKGRKSSAAASTGEKNGSGASASAGSGVVNGDFDKPYAEMTKSEKMSWSMRRRWASGEMQGAVEKRRTTLANKKAERAAANANNSSNNNTSQNGNGTNQAPSNTDSAPSSAGPSDPTTPASLTGGPLALPRGSVGGLTMHPPQHQVHGIMQQPLMPGQRMLEYGMQHGQLPPPMQPQQPHGQQHPGIGRMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G0SI58</accession>
    <name>G0SI58_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0074590</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697710.1">
        <property type="nucleotide sequence ID" value="XM_006697647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SI58"/>
    <dbReference type="GeneID" id="18261497"/>
    <dbReference type="KEGG" id="cthr:CTHT_0074590"/>
    <dbReference type="eggNOG" id="ENOG502R5ZB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_534189_0_0_1"/>
    <dbReference type="OMA" id="ECSHATP"/>
    <dbReference type="OrthoDB" id="5426982at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="510" mass="56583" checksum="7DA0F3F12FC0F21A" modified="2011-10-19" version="1">MAIPRAEPLHPAIAPALLHADPHAVTQQSSVPSSQESIEPRRLTRVDFTVEYREELLEDSRQETCLRRKRPEEECSHATPCQHRFQLAAVRGPSIERQPLSFSSCIRTSFSDINIFASSPQTRPPDAMRTETLMLMASDLLSRVAAPACFKLQSHSASFNQTMVSWLTDPDLQLPSGSIVGLCCSSLLGLQFQDETVGEQGLIVDFQRFLLATTLVQSGWHGDRQSTKLRDITAAAQISGCRLIKRLDRILTPQFLACCDRESCQVLFLLVLGTVLGVGYYSPTRMAEFSPSFLLNSLTPESQRSPTRWIAMKAQLCKMLAHHLIFIGSMLGIELDKGLEQRIIDTATMRWNKAELFVWGELQMKSNEQIPPDVFGLSGFSSKRKSDECGGSSRAGPLGGSKDPIWADLPNPLIPVPVLDQVPPPTVFPATVEPQQQQWSDNPQSWYAMFDQPDSTPKEAPPHEEPHRPITSSSRSLEPEFLVGRNAGQYGLSDRSMQDPNTGQSAFMPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0RXT5</accession>
    <name>G0RXT5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0000320</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ZNF598/HEL2 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="GL988030">
        <property type="protein sequence ID" value="EGS24101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690587.1">
        <property type="nucleotide sequence ID" value="XM_006690524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RXT5"/>
    <dbReference type="STRING" id="759272.G0RXT5"/>
    <dbReference type="GeneID" id="18254070"/>
    <dbReference type="KEGG" id="cthr:CTHT_0000320"/>
    <dbReference type="eggNOG" id="KOG2231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008515_1_0_1"/>
    <dbReference type="OMA" id="VFTHEHT"/>
    <dbReference type="OrthoDB" id="3838338at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16615">
        <property type="entry name" value="RING-HC_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057634">
        <property type="entry name" value="PAH_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041888">
        <property type="entry name" value="RING-HC_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056437">
        <property type="entry name" value="Znf-C2H2_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044288">
        <property type="entry name" value="ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938">
        <property type="entry name" value="ZINC FINGER PROTEIN 598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23202">
        <property type="entry name" value="PAH_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23230">
        <property type="entry name" value="zf-C2H2_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="93"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="365"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="627"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="705"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="627"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="714"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="724"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="746"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS24101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="758" mass="82300" checksum="F382045294D8FCC7" modified="2011-10-19" version="1">MASTDAPPPTDSEDRNQSSSGPRSDGRSRGRGGRGGGGGGGRGRGRGDSGRRGRGRGQQTAPPEQTNNAKPAQSFKAKPATDEAAGGGDGEVCFICTNPISHYSIPPCNHITCHICALRLRALYKNKDCPHCRTSSPFVIFTDDITKRFDQYADSEITSTDQNIGIKYVGEDIVGDTVLLLRYNCPDPSCDFAGLGWPDLHRHVQSVHRKKMCDICIRHKKVFTHEHELFTSDELKAHMRYSDRRPGAADQTGFRGHPLCEFCGVRYYDIDKLWEHCRDKHERCFLCDRRDSRQPHYFPDYDRLEEHFSKEHYLCPYQECLEKKFVVFETQMDLQAHKLSEHGESSRGREARIVDLSNFTLRQRYEQERSAASRTTRRREPEPAPESLHSAQPTATELAPSRPLQGLQQQHQEARNRSILDSMESLTISDLSSLTPEQRATLTRHSAVIERASNLLGNDSSKIATFRQHISSYNRGSMTAQQLLDAFFALFSETASPALGTLVREVADLFEDKRKGDALNRAWNDWRAINEDYPSLPGLGGMRAGSGGSGAGNWAAAAAAPLSAADSAAAIAADLGRSARVLKLKSSTLKGTAARPGTGAAASSWAATASSSRAPLVDSPDAFPALPSVSSSAQSKQKQPSSWGAAASGSTPTITTTTASKTAANAAKKSAPPLSSSEAFPALPAAPKVQTTAFGYGRGAVRRDWGVSRDTGFTWGGTNGGQETGSSSQQDQPGQVEGEHAAEGKGKKKKKQVLVHWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G0RXW4</accession>
    <name>G0RXW4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0004520</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690992.1">
        <property type="nucleotide sequence ID" value="XM_006690929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RXW4"/>
    <dbReference type="STRING" id="759272.G0RXW4"/>
    <dbReference type="GeneID" id="18254490"/>
    <dbReference type="KEGG" id="cthr:CTHT_0004520"/>
    <dbReference type="eggNOG" id="KOG0273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018409_0_0_1"/>
    <dbReference type="OMA" id="VNFLIWR"/>
    <dbReference type="OrthoDB" id="1367865at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045183">
        <property type="entry name" value="Ebi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846:SF2">
        <property type="entry name" value="F-BOX-LIKE_WD REPEAT-CONTAINING PROTEIN EBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="569"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="173"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="662"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="214"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS23750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="708" mass="77734" checksum="5FC5E4C02E63F7B2" modified="2011-10-19" version="1">MATAPNPHWARGPQPRIQIAGPERQRNAKAFNLQSSTIPFDGAPVIVDIAAPTTLPDSITTLTSHSHLRCSAATLRFPQLPASAPQTPPATMKELLDTDRVNFLVWRYLLESNYRETAAKLQKEWRVHQPHRQFDFAPHVNTYALVSLLNKGLIYEDYQRQFAAEQARLAAPGTEIPEPRGVFGPLKYHTDQPVDEDEEDDEESEPEPEPEEIENPRKRLVDRPHHDLSQGSPAKRKRLSNGYDNGAAADSATTPMDVDHPAESNGHAYPSPLEGEQPESPLARTEGPSRGTQVEKVRDLTHGTVFLRLSSDESTEPSDNPIVLLSEWNPRDPSVLATAGTDALARIWTLPKTSISGSAPDTISDEIANNHVTTPTRTSAASINIVEEDLPKNATISAMAWSASGEFLATGAELGSKSRVSIWTASGTRVQGFDGLDSPITNLCWSPNNNYLLAISPDVSNGPENTGTLIHVSSPSTPNSMSHVLEHDLRADSLDAAWISETEFILCGGNLLVSFRCTEQGIVPMKEFATGKDERFSLVQFDCRSKLVATASDKGTVDIWDESGKRRTFPAHDGPITSLKWQPLQSEPTEDERLLVTGGEDGSIMVWNVRGTDTKPKFAITMPPPLAVNNLSLSPDGQFIAVATHDRVLVWQIDDHVLPKATWEPQPGWQSPNANGDTEDGIPCLDWDMEGNRLVYGLDNRLAIINFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G0RXZ5</accession>
    <name>G0RXZ5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Histone deacetylase</fullName>
            <ecNumber evidence="3 11">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0004840</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 17">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the histone deacetylase family. HD type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="3 11"/>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691023.1">
        <property type="nucleotide sequence ID" value="XM_006690960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RXZ5"/>
    <dbReference type="STRING" id="759272.G0RXZ5"/>
    <dbReference type="ESTHER" id="chatd-g0rxz5">
        <property type="family name" value="Arb2_domain"/>
    </dbReference>
    <dbReference type="GeneID" id="18254522"/>
    <dbReference type="KEGG" id="cthr:CTHT_0004840"/>
    <dbReference type="eggNOG" id="KOG1343">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007727_4_0_1"/>
    <dbReference type="OMA" id="CFVSPAC"/>
    <dbReference type="OrthoDB" id="424012at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031078">
        <property type="term" value="F:histone H3K14 deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000005">
        <property type="entry name" value="histone deacetylase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019154">
        <property type="entry name" value="Arb2-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017321">
        <property type="entry name" value="Hist_deAcase_II_yeast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF5">
        <property type="entry name" value="HISTONE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09757">
        <property type="entry name" value="Arb2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037919">
        <property type="entry name" value="HDAC_II_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="13">
        <location>
            <begin position="100"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Arb2-like" evidence="14">
        <location>
            <begin position="478"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF09757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS23781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="751" mass="84150" checksum="4D5E548FD25FFACD" modified="2011-10-19" version="1">MDAHDDVIMDGEDHRMTDGPLASNGFRDATTGESSLETTNVQSTAGTSKGEEEEEEEGGSSSQLVYPEHFRRRGLLPTGCCYDDRMKLHANADFGPNPHHPEDPSRIEHIMQTFKKAGLVFTGSDAELARIIKTEPTKYMWRIPARPATKEEICMVHHPRHYLWVEELSRKSTQELRHLSAIMDQGRDSLYVGSMTYEASLISAGGAIETCKSVVTGVVKNAFAIIRPPGHHAEYDQPMGFCLFNNVPIAAKICQADYPDLCRKILILDWDVHHGNGIQNLFYDDPNILYISLHVYRNGEFYPGKPDNPMTPDGGIEHCGAGPGLGKNVNIGWHDQGMGDGEYMAAFQKIVMPIAHEFNPDLVIISAGFDAAAGDELGACFVTPACYAHMTHMLMSLAGGKVAVCLEGGYDLEAISKSALAVAQTLMGEPPPKMEIPKISREAAKVLAKVQAYHAPYWECMRPGVVDVQELQLQDSSRLHDVVRRAQRQVLSEKHGMLPLYIQRDVLYKSFENQVLVTRGISEARRLLVIVHDPPELHAQPDPLDNRVEPHNAWVTDGVLRYIDWAISKDFAVMDINVPHYITHPEDTDAYTPRADERTLQAQIQDLMCYIWDNYLQLYDCVEDIFLMGVGNAYLGIKMLLIYRPDVKRRVSGVVNFVNGALRPVKSDVDTELSQWYKNNSQVYVTNDHACWADADLARKVLKRRFGNVIRSEAKGLSAMMATHFQDVQQFILERMTPPEEVGETTEEEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0RY88</accession>
    <name>G0RY88_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative mitochondrial phosphate carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0005820</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691116.1">
        <property type="nucleotide sequence ID" value="XM_006691053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RY88"/>
    <dbReference type="STRING" id="759272.G0RY88"/>
    <dbReference type="GeneID" id="18254620"/>
    <dbReference type="KEGG" id="cthr:CTHT_0005820"/>
    <dbReference type="eggNOG" id="KOG0767">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039456_1_0_1"/>
    <dbReference type="OMA" id="TCCAITH"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000024">
        <property type="entry name" value="MIR1p Mitochondrial phosphate carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF12">
        <property type="entry name" value="MITOCHONDRIAL PHOSPHATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="13"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="111"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="209"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS23874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="293" mass="31379" checksum="4F3BD72F54A947BB" modified="2011-10-19" version="1">MATEQKQQLSGVQLYSRFAFAGAVCCSVTHGALTPVDVVKTRIQLDPKTYNNGMLGGFKKVIQNEGAGALLTGVGPTFVGYFLQGAFKFGGYEFFKQQHINFLGYETASKYRTGVYLASSAAAEFFADVALCPLEATRIRLVSQPTFASGLLSGFGKILKNEGVGAFYAGFGPILFKQIPYTMAKFVVYEKVAEAVYRVWPKKDMSDGLQTTVNLGSGLIAGFAAAIVSQPADTMLSKINKTPGLPGESTTSRLIKIGKELGIKGSFTGLGARLFMVGTLTAFQFAIYPLVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYP0</accession>
    <name>G0RYP0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Conidiophore development protein hymA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0007370</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mo25 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS24026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691268.1">
        <property type="nucleotide sequence ID" value="XM_006691205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYP0"/>
    <dbReference type="STRING" id="759272.G0RYP0"/>
    <dbReference type="GeneID" id="18254775"/>
    <dbReference type="KEGG" id="cthr:CTHT_0007370"/>
    <dbReference type="eggNOG" id="KOG1566">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035755_0_0_1"/>
    <dbReference type="OMA" id="AYDHKES"/>
    <dbReference type="OrthoDB" id="609103at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000257">
        <property type="entry name" value="Conidiophore development protein hymA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013878">
        <property type="entry name" value="Mo25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182:SF3">
        <property type="entry name" value="PROTEIN MO25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08569">
        <property type="entry name" value="Mo25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS24026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="44513" checksum="9D200EB8F6DF5874" modified="2011-10-19" version="1">MSFFFSRTRAKTNGADLARQAREHVTKLEGPQGATKAEELAKVLSQMKQLLQGTHDQEANPDQIFQLVNGLIEEDLLYLLAVNLYRLPFESRKDTQVIFSYVFRFRPPNHLLAHTSSQHYHAAPQRPEPYALAYVVERRPQVLIELCRGYDHKESATPAGTVLREVIKNEAAAAVILYDDGEEPGSSVRGVQAIDWNRQQSGKGVFWQFFEWIDKSSFEVSADAFTTFRELLTKHKELVPRYLATNFELFFSKYNTILVQSNSYVTKRQSIKLLGEILLDRSNYNVMTAYVDRGEHLKICMNLLRDDRKMVQYEGFHVFKVFVANPNKSIPVQKILIMNREKLLHFLSHFLEDRTDDEQFIDEREFLIKQIRNMPPAPVPPSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYY4</accession>
    <name>G0RYY4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0001010</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690654.1">
        <property type="nucleotide sequence ID" value="XM_006690591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYY4"/>
    <dbReference type="STRING" id="759272.G0RYY4"/>
    <dbReference type="GeneID" id="18254139"/>
    <dbReference type="KEGG" id="cthr:CTHT_0001010"/>
    <dbReference type="eggNOG" id="KOG2084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028281_6_0_1"/>
    <dbReference type="OMA" id="CKPRTER"/>
    <dbReference type="OrthoDB" id="438641at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF6">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="86"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="362" mass="40394" checksum="3D1092B6FDC16027" modified="2011-10-19" version="1">MQLRVKDVQAPQFTYLYNLLPYCENDTNYCVFTNANFPGPNRGVSIIDEQPTPGEDRSSSPALKTISSLLSFPLPSVIPKARQDSPPYEVRDIPGKGKGLIATRKIPRGKVFMVDYASLIIDIQLPNKVKRDQGRRLLKEAIERLPSADLILNLARSSPDLQNVPVWEDVVKTNSFSIEIGGRGYMALFPKIARINHACKPSALTNFNSTDLSNKVTAFHDILPGDEITISYTPFALPTLTRRALLLQTWGFTCICPLCTLPPSQLALSDTRRKKILSLGEEVVQILSKSTDKNMMRKAAKMYEEVVQAIKEEGLMPHMGEHYEILGGLLVGAGEVKRGNEMIRLAREERRKWEEGRGVGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2023-02-22" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYZ7</accession>
    <name>G0RYZ7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0001140</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690667.1">
        <property type="nucleotide sequence ID" value="XM_006690604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYZ7"/>
    <dbReference type="GeneID" id="18254152"/>
    <dbReference type="KEGG" id="cthr:CTHT_0001140"/>
    <dbReference type="HOGENOM" id="CLU_2542376_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS23425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="83" mass="9088" checksum="D6485E63F55255F0" modified="2011-10-19" version="1">MGWQPADSLGHVALLRLSIPSTILECQYSAPATTDQIYDSNIKKENTILTKLGDVLHQQELLCCDLDVAAEETESLVDGELTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZD3</accession>
    <name>G0RZD3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cyclin dependent-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0002560</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23561.1"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="eggNOG" id="KOG1161">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2421">
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    <dbReference type="HOGENOM" id="CLU_002842_1_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="SPX_PHO81_NUC-2_like"/>
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        <property type="entry name" value="Similar to CUE domain-containing protein"/>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
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        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
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        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
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        <property type="entry name" value="Ankyrin_rpt"/>
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        <property type="entry name" value="C2_GPCPD1"/>
    </dbReference>
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        <property type="entry name" value="CUE"/>
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    <dbReference type="InterPro" id="IPR041807">
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        <property type="entry name" value="GP_PDE_dom"/>
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    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
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        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
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        <property type="entry name" value="SPX_dom"/>
    </dbReference>
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        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461:SF5">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
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        <property type="entry name" value="Ank_2"/>
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    </dbReference>
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        <property type="match status" value="8"/>
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        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
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        <property type="match status" value="4"/>
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        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CUE" evidence="6">
        <location>
            <begin position="69"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="7">
        <location>
            <begin position="503"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="841"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="908"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="940"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="976"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A2" evidence="5">
        <location>
            <begin position="993"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="8">
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            <begin position="1236"/>
            <end position="1573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
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            <begin position="111"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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            <begin position="240"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1033"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="264"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
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            <end position="335"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
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            <end position="373"/>
        </location>
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        <location>
            <begin position="418"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1034"/>
            <end position="1044"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
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            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS23561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1576" mass="171866" checksum="FBF2C7DEAC5B8305" modified="2011-10-19" version="1">MADPSKLPPGPESPTTARPLEMDDDESQETLGAEDAAVKTATTPAAVANAPAAAQEEVPPPKPPRPLTEAQKNQQILKEAFPTVELPVIKAVLTASGGRIEAAFNALLELTDPEAAERDRPPAQPPRPAAEPVPTRTSTDPRQLEADERYARQLAEHYENVSAYEARASNRAYRGGSSGIPPSRGRPQPRDYDREREHSFLDDDLPVIKESLRKGFLETQTKVNTWISNLKKKIDEQFEEFADDDDDDDYGRRRTRGGGFLGRPSREQSRRSAEYDRYDADPELLSDDFAGMKFHNDGIQPLSGPSRSNPNFYRPPPPAKSPKPDGRRVAFRETVEDIDAYNASPRISPKDGPAAGTTGVSTSSTATATGKSSKWQPLSPVDPNPIAENDPFSLGDSDDEREAVVSRDGSKGSSSGIRLEDAESAEQQRLRQATADAMAESLQGCPTLNGLGTRFDGFNITGSEPDSGTFVRPHPTTSQPSRIADTLFVPGIALAAFNSRFLTKFGKQIQKRALELPEYAASFVNYKALKKLIKKLSATPVLQPQDGVQGVEARPLDPQAALQANKATFFFQLERELEKVNAFYLQKEAELKVRLKTLLDKKRVLQSRGYTISRRSAKFTTLQEGFQQFAADLNKLQQFVEINGTAFSKILKKWDKTSKSKTKELYLSRAVEVQPFFNATVISELSDQATTSLQELAAWADGDNVTFETRIDHVVHSQHLPGTDEGDADTLLLDTVLSGNIEALRDLLNRMNAMTAGDQNTNGGVVDVVLLERITRAFLAGVNGASLEALKVLLDTGLVDIQSEDDINERNCLHQAAIHGNVWVLEYGLSHGVAADRTDVYGRVPLHYASIHGRLDMVDTLLNAAPHTIDVIDHDNYTPLIHSIVNKNLECVARLLERSARLDPVSDNDHVPLNIACEHGSLDIAEMLLRHGARILPDAEGLYPQHLVARSSQQKPELLLLLKTYGADLDQVDKLYGWTPLVHAASEGNVPCLQALLEMGADPGILDEKELPAMYYAAWEGHLECMQLLTQANQRREQEKEPEKKRKQVASGGLLAPMDSSTAPAPMSLDGADADAIPVLELPPPIIPLRRYGHNFLDTKTVVQLCFGGDKGEHAPLVFFQDSKYPAARLTISSKSSSDVIPKNIMLPFQEDTRSVSFQIDNLDAFTLDFDVFPAYGAKVIARTVALPSTFCALLGSNSAGNLCSLPLFDLRLRAIGQLTFTAHIIKPFQGKPLEITDFETYWKATTTPSAAVGTVNNHHAAFDAASSSTFITGSSLSGDFVRIYVQHTADGVPVVWPRRTVTIPLPFSSGAGIDGGNGIEIPVWRLSLAQFLTATGPPPPSPLPADVAHQPAKVHALFASAGATTLRDALALLPRGMHVNIQVLSYPPSYDENGSAPAAAMDVNTIVDAILSVVFDHARTQRRARSQGTDGGVGPRSVVFSSYSETICAALNWKQPNFPVFLCNDLGRNQHEKEEGMQMGDGGRRRSRGTSIKEAVRMAQSNNFMGLICSAKLLEMVPALVDAIKSHGLALVVDKSGESPEQQQHAADLFSRLPHGIDGVLKSDGVLRFNESIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZF3</accession>
    <name>G0RZF3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTPase activator-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0002760</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690823.1">
        <property type="nucleotide sequence ID" value="XM_006690760.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0RZF3"/>
    <dbReference type="GeneID" id="18254314"/>
    <dbReference type="KEGG" id="cthr:CTHT_0002760"/>
    <dbReference type="eggNOG" id="KOG1102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003663_1_0_1"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="TBC domain-containing protein C1778.09"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="982"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="709"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="924"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1187"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1294"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="316"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="407"/>
            <end position="431"/>
        </location>
    </feature>
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        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="512"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="566"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="630"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="927"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="937"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1189"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1200"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1294"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1333"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1344"/>
            <end position="1372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1380" mass="150354" checksum="7601B43492A84C3B" modified="2011-10-19" version="1">MPFPSWSCSSSLGSLLGILGGKPSRSSSSSDSSSSSARTHTRSQSQPLPQTRPQSQTQARAHKRGSSVLKLQGRLDQIGLGLWSQGASASAAKATARAAAVPLLLPPNSSASMESAQEKPKSKQKPTTPQKHVTVRHKGRPVARLALSPFRDDSGLVALRYEHTKQGEPPIPLPPPQPREKKREIRRPIIVNPPPVPPPQEEHPLFRNQQTQTQTLQTSQTITIRRSQAEPWKRDSGAPTSSSITLRGDEDEEDYIYRKLLEDIADAPSPTLPPMQSPKMDDSSFEAPQELPARKIPPPALKLPVPLSAGRAEIQPPASAPVSVPGAKQTPTQQQQPATTPSSPSPSRLGLRRAVSVSCSSPRSSESPSSPVLPASPSRHLSLTKKLGKKSFGLGSGSSGNEKGKTDTATAAATVGTGISSRVSVVSSGGSKRLRKKRVGVDRAASGAGTVGPASPGAISGPERGSAHCAQQEKPPKWPKTAKRTPETPPQPNAPGAAHGEQASSHSNKNKSTVADTVTSATTLSLSSAPTITTPIPSHSLWDDLDSIAFSKRGSLMLLGRKSDPSKSLPLSLSQVMSSSSAESGPSDCRAGETPNVIEESKPNVSEESENTESPEHKETDKNTSQVPASSSPSSSSSSSTSSKSQRDSANVAASPSARDAAKGPEPAVPSIRVSSIDLERESQKVRSLYESGDDLFWEDGGRVSFVERLAPTAEVPSEEDEHADSWRPSDHPSSSQGDHLGPFPQATAIPRSRLSASPNRNSVVRKGYAGGLEDWDDLDGAEVDRYGFITPKRPVSRAEPAELKVLPRRRNVLTKRPSTSYSTVSLPGGFIRPPSRKVSARSLNTYTSERSNVSRLSTRSSIRSAANHLPYNREHRWLAEASEMLSLQPTGFASLEDEKDPKLIEAQKRKEALRSEKWRKMATAVTPVSSNPKVTSSSSSSSSSSSSSSSTNPPPAPGHGQGISYTFDVTSPKLISRTWKGIPDCWRSAAWYSFLHTSAITYPHDPPESDAYLIETFHALQSRPSPDDVQIDLDVPRTVSGHVMFRRRYRGGQRLLFRVLHAISLYFPEVGYVQGMASLAATLLCYFDEERAFVMMVRLWRYRGLGWLYSDGLAGLMAALREFEGDWLGKLDGGVVKEKLNELSIDATAYGTRWYLTLFNLSLPFQAQLRVWDVFMLLGECPPEEQKQLQQLQRQQQQSSGDPQPSTSNDSSPKDLDPPPQSPATLLPPKGLDILHATSAALIHALRDVLLDSDFENAMKTLTAWIPVKDEDLLMKVAQAEWRRHQGRREKIEKELREKTKKEEKQREKEEKQREKEKGKGKEKENVKEGVEVTTTTTNTKGKVKEREQQHDKERDEARGKEKEKEKDKKDKGKGRSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZP4</accession>
    <name>G0RZP4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0003690</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690914.1">
        <property type="nucleotide sequence ID" value="XM_006690851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZP4"/>
    <dbReference type="GeneID" id="18254407"/>
    <dbReference type="KEGG" id="cthr:CTHT_0003690"/>
    <dbReference type="eggNOG" id="ENOG502S78G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065222_1_0_1"/>
    <dbReference type="OMA" id="MGNHIAD"/>
    <dbReference type="OrthoDB" id="408760at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00229">
        <property type="entry name" value="SGNH_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051532">
        <property type="entry name" value="Ester_Hydrolysis_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383:SF19">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383">
        <property type="entry name" value="THIOESTERASE 1/PROTEASE 1/LYSOPHOSPHOLIPASE L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="270" mass="30521" checksum="13718715CD854D52" modified="2011-10-19" version="1">MTTAALPKQPRPSKLRILCFGDSLTAGYCSMGAMFHPYHERLEQMLAMAFPDIAFETVEDGVPGDTVRFGFMGRMYHHFPQKNAKILQNQADTNGYDWTIVLGGTNDIAMGVPPEEIYNTLKEVWDYALVNNSKVLALTVPEAALDPSALRERLAARRNKLNDLIRSHKADNFHVFDLHAALPYLSMTPSDRQRYWDDTVHFTPAGYDLIGNKVGMALVKLLEAEGLGTPPRLPKRRRMFKDDDLEFEEENGDETEISKGYVVVRRADLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2023-02-22" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZU0</accession>
    <name>G0RZU0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0004170</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690960.1">
        <property type="nucleotide sequence ID" value="XM_006690897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZU0"/>
    <dbReference type="GeneID" id="18254455"/>
    <dbReference type="KEGG" id="cthr:CTHT_0004170"/>
    <dbReference type="HOGENOM" id="CLU_2003657_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS23718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="124" mass="13375" checksum="733629913BAED2DB" modified="2011-10-19" version="1">MAAAAPAKANFCSSKFNDFNNSTISPALLQTLIQTEPANTRSQDPDSLASVERPKPAAVAVESSLAHSTMPITRDQQYNRPVVYHFLANPQPSPVLLLILPSPHQLIATSVTGPFAFLLHAVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZU7</accession>
    <name>G0RZU7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0004260</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690967.1">
        <property type="nucleotide sequence ID" value="XM_006690904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZU7"/>
    <dbReference type="STRING" id="759272.G0RZU7"/>
    <dbReference type="GeneID" id="18254464"/>
    <dbReference type="KEGG" id="cthr:CTHT_0004260"/>
    <dbReference type="eggNOG" id="ENOG502QWBF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013756_4_1_1"/>
    <dbReference type="OMA" id="FASKSIM"/>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="525"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="558"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="590"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="69"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS23725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="613" mass="65999" checksum="7ECD0D11AC2FFB1C" modified="2011-10-19" version="1">MMSGCCFNGFVARRLVPVYISLLLSVRPEPHVYSVFPPERSAVISPATTPYDPDTLAYLDLSEPSSARMSYQTTRTSGLTLGQGLTLDTDTESSTHYTERTPLLAGTPTPPPSSPVPSRLPSPARGDNSRRSSRTNYGNDDGVRGGFSALEQVKSQLRKRVIPLAMVLIFLLELSVGIMQPPQNAIMESIICRKMHPEVFTPPPPGTGPEEGLLPPALPGPDNLDHMSLAMSGPRTIPSRPVRPRLRYYPGLVLADDPLCKGSDVQGYLATVVGWQSTFDNFFSRFVPLRVVWFSSAFQLIGGGGAVAIAMMYTVIADVVAISTRATVFFHMTAAFLASQMIAGPTGGTLLAWNPWIPLLLALALLVICCFLAFFAMPETVHVHDHHNTSAALDEDDDPAASKLLRKARAGLEEVYTFILGNTRLAFLIISMVFIILGRIVGEVLLQYSTDRYGWSWTKASLVLTIRNAGSLLTLLVLLPAASWVLISRRGLSAMEKDLCLARWSGVVQVVGSVVIAAAGNGVMYAIGLVWFAAGAGMTSVVRSLLNALVEEHHVGTVNSLIGFMEMISVAAASPMIAESLKLGLKLGEPWVGLPFITAAVFFGVATVIISKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZV3</accession>
    <name>G0RZV3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetylmuramoyl-L-alanine amidase</fullName>
            <ecNumber evidence="2">3.5.1.28</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0004320</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.</text>
            <dbReference type="EC" id="3.5.1.28"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.5.1.28" evidence="2"/>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690973.1">
        <property type="nucleotide sequence ID" value="XM_006690910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZV3"/>
    <dbReference type="STRING" id="759272.G0RZV3"/>
    <dbReference type="GeneID" id="18254470"/>
    <dbReference type="KEGG" id="cthr:CTHT_0004320"/>
    <dbReference type="eggNOG" id="ENOG502SI9P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1176107_0_0_1"/>
    <dbReference type="OMA" id="NANTWDE"/>
    <dbReference type="OrthoDB" id="5358886at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007921">
        <property type="entry name" value="CHAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05257">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50911">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51781">
        <property type="entry name" value="SH3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409165" description="N-acetylmuramoyl-L-alanine amidase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="5">
        <location>
            <begin position="19"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C51" evidence="4">
        <location>
            <begin position="107"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS23731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="237" mass="25676" checksum="061A7C2A47081206" modified="2011-10-19" version="1">MKFSIIAGFLQALALTSLVEGYKITGNNVNCRSGPGTSYSVKKTYAKGTDVKITCQTTGTNINGNNIWDKTSDGCYVSDYYVKTGTNGYVTTKCSSSGSGNSASIPGPMTDDYPYKSSCGGVDPWNYYKCQCTSFVAWRINKRLGIKFTNRYKGGTWGNANQWDDAAKKVGVKVDNNPKPGCIAQTDNGGGGYGHVAWVAAVNGDKVTIEEYNYAKPKGYGKRTVPKSTFKYIHIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0S006</accession>
    <name>G0S006_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0008280</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691358.1">
        <property type="nucleotide sequence ID" value="XM_006691295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S006"/>
    <dbReference type="STRING" id="759272.G0S006"/>
    <dbReference type="GeneID" id="18254866"/>
    <dbReference type="KEGG" id="cthr:CTHT_0008280"/>
    <dbReference type="eggNOG" id="KOG1161">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4580">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009308_2_0_1"/>
    <dbReference type="OMA" id="SFKFWVH"/>
    <dbReference type="OrthoDB" id="6493944at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14480">
        <property type="entry name" value="SPX_VTC2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.100.30:FF:000002">
        <property type="entry name" value="Vacuolar transporter chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF2">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 3 COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="781"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="823"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="8">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="84"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="614"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="694"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="114"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="624"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="643"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="655"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="694"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS23167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="875" mass="99637" checksum="74CF1B8940FC8DF3" modified="2011-10-19" version="1">MRFGKTLKQSMYGPWKDQYIDYALLKSILREDRPDDEDEPWTEDDENRFCDEVFNIQLEKVAKFQADKVEDLRRRVDDAFARLKELPSSRGGGAETEKHHKEQRDREGEGEEEGGGRDKGKGRDEGEAEEEAPKPRKKSDAEIQRLRDLEAELDSITNEVKELKKYSSLNYTGFLKIVKKHDRKRGDRYKIRPLMQLSLAKRPFNSEQAYSPLLTKLSLMYFAIRQQLEDEPSAGPESFPPADPDSQSETHNGERYTAHKFWVHPDNLLELKTYILRQLPALVYSDKSVKDVEVQQEDPRITSLYFDNHKFDLYSRKVERETDVSSLRLRWYGQLRDRPEIVLEHKLLHANGTSEERRFAIKEKYVKPFLDGEYHMEKSIQKMERQGRSPEEIAAFRSTADAISEFVRENKLEPVVRANYVRTAFQKPGDDRVRILIDTDIVFIREDTLDRDRPCRNPREWHRLDIDNANMTYPFHNINQSEVSHFPYAVLEIKLREDAGRGNRRIAWVQDLMHSHLVHPCPRFSKFVHGTASLFEDYVNRLPFWLSDLDTDIRKDPQVAFEEEEERRARQAENEQAVGSLLGGKIAAATSASAAARRLSRSSPVAKSYLEGRLAAESTPKTPPSATFLSNSMTGAGPGRAEEQEEEEGEPTEDQPLTQTQSKRQRRQGNTLLNYGTLFPSFTSLTKYSRFRRISQSAGGPPQSQAESRRRASLASLPLPPGVTEPEEWLKNSGPLQIEPKVWLANERTFLKWAHISVLLGGLAVSLYSAGGAQHGGKGDLLTQAMGVAFLGVAAFAAGWSYWVLEKRREMIIMRSGRDFDFVVGPLVVSGALMVALVVNLVIAWKRVFAGGEEGVVGGIRGLGNVSSEVVDLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>G0S061</accession>
    <name>G0S061_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Pentafunctional AROM polypeptide</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="21">3-dehydroquinate synthase</fullName>
                <shortName evidence="21">DHQS</shortName>
                <ecNumber evidence="21">4.2.3.4</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
                <ecNumber evidence="21">2.5.1.19</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="21">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
                <shortName evidence="21">EPSP synthase</shortName>
                <shortName evidence="21">EPSPS</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">Shikimate kinase</fullName>
                <shortName evidence="21">SK</shortName>
                <ecNumber evidence="21">2.7.1.71</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">3-dehydroquinate dehydratase</fullName>
                <shortName evidence="21">3-dehydroquinase</shortName>
                <ecNumber evidence="21">4.2.1.10</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">Shikimate dehydrogenase</fullName>
                <ecNumber evidence="21">1.1.1.25</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="28" type="ORF">CTHT_0008860</name>
    </gene>
    <organism evidence="29">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="30" key="2">
        <citation type="journal article" date="2020" name="Nat. Chem. Biol." volume="16" first="973" last="978">
            <title>Architecture and functional dynamics of the pentafunctional AROM complex.</title>
            <authorList>
                <person name="Arora Veraszto H."/>
                <person name="Logotheti M."/>
                <person name="Albrecht R."/>
                <person name="Leitner A."/>
                <person name="Zhu H."/>
                <person name="Hartmann M.D."/>
            </authorList>
            <dbReference type="PubMed" id="32632294"/>
            <dbReference type="DOI" id="10.1038/s41589-020-0587-9"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) IN COMPLEX WITH L-GLUTAMATE; NAD(+) AND ZN(2+)</scope>
    </reference>
    <comment type="function">
        <text evidence="20 21 22">The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 22">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:21257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 22">
            <text>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21968"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="EC" id="4.2.3.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 21 22">
            <text>shikimate + ATP = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 22">
            <text>shikimate + NADP(+) = 3-dehydroshikimate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21 22">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="21 22">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21 22">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 21 22">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the 2nd section; belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the 3rd section; belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the 4th section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the C-terminal section; belongs to the shikimate dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="22">In the N-terminal section; belongs to the dehydroquinate synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21">In the N-terminal section; belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.4" evidence="21"/>
    <dbReference type="EC" id="2.5.1.19" evidence="21"/>
    <dbReference type="EC" id="2.7.1.71" evidence="21"/>
    <dbReference type="EC" id="4.2.1.10" evidence="21"/>
    <dbReference type="EC" id="1.1.1.25" evidence="21"/>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691413.1">
        <property type="nucleotide sequence ID" value="XM_006691350.1"/>
    </dbReference>
    <dbReference type="PDB" id="6HQV">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="A/B=1-1581"/>
    </dbReference>
    <dbReference type="PDBsum" id="6HQV"/>
    <dbReference type="SASBDB" id="G0S061"/>
    <dbReference type="SMR" id="G0S061"/>
    <dbReference type="STRING" id="759272.G0S061"/>
    <dbReference type="GeneID" id="18254924"/>
    <dbReference type="KEGG" id="cthr:CTHT_0008860"/>
    <dbReference type="eggNOG" id="KOG0692">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001201_1_2_1"/>
    <dbReference type="OMA" id="SWANMSW"/>
    <dbReference type="OrthoDB" id="197068at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08195">
        <property type="entry name" value="DHQS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000135">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001256">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.65.10.10:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.65.10.10:FF:000008">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="entry name" value="Enolpyruvate transferase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03143">
        <property type="entry name" value="Pentafunct_AroM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00109">
        <property type="entry name" value="Shikimate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018508">
        <property type="entry name" value="3-dehydroquinate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016037">
        <property type="entry name" value="DHQ_synth_AroB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056179">
        <property type="entry name" value="DHQS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008289">
        <property type="entry name" value="Pentafunct_AroM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010110">
        <property type="entry name" value="Shikimate_DH_AroM-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000623">
        <property type="entry name" value="Shikimate_kinase/TSH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023000">
        <property type="entry name" value="Shikimate_kinase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01357">
        <property type="entry name" value="aroB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01093">
        <property type="entry name" value="aroD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01809">
        <property type="entry name" value="Shik-DH-AROM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090">
        <property type="entry name" value="AROM/DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090:SF5">
        <property type="entry name" value="PENTAFUNCTIONAL AROM POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24621">
        <property type="entry name" value="DHQS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000514">
        <property type="entry name" value="Pentafunct_AroM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01100">
        <property type="entry name" value="SHIKIMTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01028">
        <property type="entry name" value="DEHYDROQUINASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EPSP_SYNTHASE_1"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS00885">
        <property type="entry name" value="EPSP_SYNTHASE_2"/>
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    <dbReference type="PROSITE" id="PS01128">
        <property type="entry name" value="SHIKIMATE_KINASE"/>
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    <proteinExistence type="evidence at protein level"/>
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    <keyword evidence="15 21 22" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="12 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 21 22" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 21 22" id="KW-0418">Kinase</keyword>
    <keyword evidence="16 21 22" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 21 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17 21" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="13 21" id="KW-0521">NADP</keyword>
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    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21 22" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 21 22" id="KW-0862">Zinc</keyword>
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            <begin position="84"/>
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    <feature type="domain" description="3-dehydroquinate synthase C-terminal" evidence="27">
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            <begin position="198"/>
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    <feature type="domain" description="Enolpyruvate transferase" evidence="23">
        <location>
            <begin position="410"/>
            <end position="838"/>
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    </feature>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="25">
        <location>
            <begin position="1295"/>
            <end position="1376"/>
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    </feature>
    <feature type="domain" description="SDH C-terminal" evidence="26">
        <location>
            <begin position="1545"/>
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    </feature>
    <feature type="region of interest" description="3-dehydroquinate synthase" evidence="21">
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            <begin position="1"/>
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    </feature>
    <feature type="region of interest" description="Shikimate dehydrogenase" evidence="21">
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            <begin position="1290"/>
            <end position="1581"/>
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    </feature>
    <feature type="active site" description="Proton acceptor; for 3-dehydroquinate synthase activity" evidence="21">
        <location>
            <position position="267"/>
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    </feature>
    <feature type="active site" description="Proton acceptor; for 3-dehydroquinate synthase activity" evidence="21">
        <location>
            <position position="282"/>
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    </feature>
    <feature type="active site" description="For EPSP synthase activity" evidence="21">
        <location>
            <position position="826"/>
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    <feature type="active site" description="Proton acceptor; for 3-dehydroquinate dehydratase activity" evidence="21">
        <location>
            <position position="1179"/>
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    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; for 3-dehydroquinate dehydratase activity" evidence="21">
        <location>
            <position position="1207"/>
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    <feature type="binding site" evidence="21">
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    <feature type="binding site" evidence="21 30">
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        </source>
    </evidence>
    <sequence length="1581" mass="171565" checksum="6CC31BC05382F456" modified="2011-10-19" version="1">MATANVAGAGGSGSEPTRIAILGKEDIIVDHGIWLNFVAHDLLQTLPSSTYVLITDTNLYTTYVPPFQAVFEAAAPRDVRLLTYAIPPGEYSKSRETKAEIEDWMLSHACTRDTVIIALGGGVIGDMIGYVAATFMRGVRFVQVPTTLLAMVDSSIGGKTAIDTPMGKNLIGAFWQPRRIYIDLAFLETLPVREFINGMAEVIKTAAIWNETEFTALEENAAAILEAVRSKASSPAARLAPIRHILKRIVLGSARVKAEVVSADEREGGLRNLLNFGHSIGHAYEAILAPQVLHGECVAIGMVKEAELARYLGVLRPSAVARLTKLIASYDLPTSVHDKRIAKLSAGKECPVDVLLQKMAVDKKNEGRKKKIVLLSAIGKTYEKKATVVDDRAIRLVLSPSVRVTPGVPKGLSVTVTPPGSKSISNRALVLAALGEGTTRIHGLLHSDDVQYMLAAIEQLHGADFSWEDAGEILVVTGKGGKLQASKEPLYLGNAGTASRFLTSVVALCAPSAVSSTVLTGNARMKVRPIGALVDALRANGVGVKYLEKEKSLPVEVDAAGGFAGGVIELAATVSSQYVSSILMAAPYAHQPVTLRLVGGKPISQPYIDMTIAMMASFGIKVERSAEDPNTYLIPKGVYKNPPEYVVESDASSATYPLAVAAITGTTCTIPNIGSESLQGDARFAVEVLRPMGCAVEQTATSTTVTGPPIGTLKAIPHVDMEPMTDAFLTAAVLAAVADGTTQITGIANQRVKECNRIAAMKDQLAKFGVQCNELEDGIEVIGKPYQELRNPVEGIYCYDDHRVAMSHSVLSTISPHPVLILERECTAKTWPGWWDILSQFFKVQLDGEEDPTKRTTQSTQQVRKGTDRSIFIVGMRGAGKSTAGRWMSELLKRPLVDLDAELERREGMTIPEIIRGERGWEGFRQAELELLQDVIKNQSKGYIFSCGGGIVETEAARKLLIDYHKNGGPVLLVHRDTDQVVEYLMRDKTRPAYSENIREVYERRKPWFYECSNLQYHSPHEDGSEALLQPPADFARFVKLIAGQSTHLEDVRAKKHSFFVSLTVPNVADALDIIPRVVVGSDAVELRVDLLESYEPEFVARQVALLRAAAQVPIVYTVRTQSQGGKFPDEDYDLALRLYQTGLRSGVEYLDLEMTMPDHILQAVTDAKGFTSIIASHHDPQCKLSWKSGSWIPFYNKALQYGDVIKLVGVAREMADNFALTNFKAKMLAAHDNKPMIALNMGTAGKLSRVLNGFLTPVSHPALPSKAAPGQLSATEIRQALSLIGEIEPKSFYLFGKPISASRSPALHNTLFYKTGLPHHYSRFETDEASKALESLIRSPDFGGASVTIPLKLDIMPLLDSATDAARTIGAVNTIIPQTRDGSTTTLVGDNTDWRGMVHALLHSSGSGSVVQRTAAPRGAAMVVGSGGTARAAIYALHDLGFAPIWIVARSEERVAELVRGFDGYDLRRMTSPHQGKDNMPSVVISTIPATQPIDPSMREVIVEVLKHGHPSAEGKVLLEMAYQPPRTPLMTLAEDQGWRTVGGLEVLAAQGWYQFQLWTGITPLYEEARAAVMGEDSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0F9</accession>
    <name>G0S0F9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CTHT_0009880</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="Acta Crystallogr. F Struct. Biol. Commun." volume="79" first="200" last="207">
            <title>Crystal structure of Prp16 in complex with ADP.</title>
            <authorList>
                <person name="Garbers T.B."/>
                <person name="Enders M."/>
                <person name="Neumann P."/>
                <person name="Ficner R."/>
            </authorList>
            <dbReference type="PubMed" id="37548918"/>
            <dbReference type="DOI" id="10.1107/s2053230x23005721"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 300-920 IN COMPLEX WITH ADP AND MG(2+)</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691511.1">
        <property type="nucleotide sequence ID" value="XM_006691448.1"/>
    </dbReference>
    <dbReference type="PDB" id="8CNT">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.90 A"/>
        <property type="chains" value="A=300-920"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0F9"/>
    <dbReference type="SMR" id="G0S0F9"/>
    <dbReference type="STRING" id="759272.G0S0F9"/>
    <dbReference type="GeneID" id="18255026"/>
    <dbReference type="KEGG" id="cthr:CTHT_0009880"/>
    <dbReference type="eggNOG" id="KOG0924">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001832_6_1_1"/>
    <dbReference type="OMA" id="VDVMFHR"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034458">
        <property type="term" value="F:3'-5' RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2130:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000018">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase prp16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000313">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF91">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="18" id="KW-0002">3D-structure</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="318"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="503"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="955"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="955"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="567"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="589"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="591"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="635"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGS23320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PDB" id="8CNT"/>
        </source>
    </evidence>
    <sequence length="1009" mass="113981" checksum="E7C456F37C4738F6" modified="2011-10-19" version="1">MGRDYDDDRSKKRRKLDFNPLRSDDRFGDIPARSHSNRNNGSLQSRSSTPRGSRLEGARTPHHRGDDGPELSPGFDADAENALDRDWYGGDDDLGGHTFGDETHNPFGDDSYWAAQEREAALAEKKMNMLSRGMMNARQLQKQKDVDAWETNRMLTSGVAQRREVGYDFEEDQEGTRVHLLVHDLRPPFLDGRTIFTKQVDPVPAVRDPTSDMAVFSRKGSRVVRERRQQRERQRQAQAATNVAGTALGNLMGVKEDDTDSAVPIASEDASKAQSSSGTSKFSDAIKKQEGASNFSQSKTLKEQREFLPAFAVREDLLRVIRDNQVVIVIGETGSGKTTQLTQFLYEDGYGKTGMIGCTQPRRVAAMSVAKRVAEEMEVKLGTLVGYAIRFEDCTSKETVIKYMTDGVLLRESLNEPDLDRYSCIIMDEAHERALNTDVLMGLFKKILQRRRDLKLIITSATMNSKRFSDFFGGAPEFTIPGRTFPVDILFHRSPVEDYVDQAVQQVLAIHVSKPAGDILVFMTGQEDIEVTCELIQERLAALNDPPKLSVLPIYSQMPADLQAKIFDRAPPGVRKCIVATNIAETSLTVDGIMYVVDCGYSKLKVYNPRMGMDTLQITPISQANAAQRAGRAGRTGPGQAYRLYTEKQFRDEMYMQTIPEIQRTNLSNTVLLLKSLGVKDLLDFDFMDPPPQDTITTSLYDLWALGALDNLGELTELGRKMNAFPMDPPLAKLLIMSEEYGCSEEMVTIVSMLSVPNVFYRPKERQEESDAAREKFFVPESDHLTYLHVYTQWKANGYSDAWCARHFLHSKSLRRAREVRDQLLDIMKMQHMRMVSCGTDWDIIRKCICSGYYHQAAKVKGIGEYINLRTSVTVQLHPTSALYGLGFLPDYVVYHELILTSKEYMSTVTAVDPHWLAELGGVFYSIKEKGYSVREKRITETEFSRRMEIEAQMAEDRKRAEEKKRQEEEEEEEGLQLSRKGKKKAGEKKVVRVGAVVKPVRKRGGIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0L4</accession>
    <name>G0S0L4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">beta-glucosidase</fullName>
            <ecNumber evidence="19">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CTHT_0010430</name>
    </gene>
    <organism evidence="24">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 19">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="19"/>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691566.1">
        <property type="nucleotide sequence ID" value="XM_006691503.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S0L4"/>
    <dbReference type="GeneID" id="18255081"/>
    <dbReference type="KEGG" id="cthr:CTHT_0010430"/>
    <dbReference type="eggNOG" id="ENOG502QR4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_2_0_1"/>
    <dbReference type="OMA" id="THNDIFW"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000003">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF20">
        <property type="entry name" value="BETA-GLUCOSIDASE E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 19" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16 19" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17 19" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="22">
        <location>
            <begin position="884"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="13"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="781"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="788"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EGS22574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1427" mass="156994" checksum="9A1E784E053E9B44" modified="2011-10-19" version="1">MVRDETRDVLLRDGKRRSLESNGPDSDSDLEATEYLRHDPYETSQQSQTEPSVNKPKSRWCACVFRTFGRRSRCCIGTLAAIFVLWIVLSAGGFFVYKKYGAEPPYGQSPPWYPTPKGGIAKSWAASYAKAAKLVSRMTLTEKVNITTGTGWQMGLAVGTTGPAVYVGFPQLQLQDGPLGVRFADNITAFPAGITVGATWNRQLMYARGKAHAIEARRKGINVILGPCVGPLGRMPAGGRNWEGFGADPYLQGVAGAETIRGIQSEGVMATIKHFVGNEQEHFRQPWEWGTPHAISANIDDRTLHELYAWPFGDAVKAGVAAVMCSYNMVNNSYACANSKLLNGILKDELGFQGFVMSDWLAQHAGVATALAGLDMTMPGDGLSWADGESLWGPQLTKAVLNGSVPVERLNDMVTRIVAAWYQLGQDDETKFPRRPPNFSSWTNDRMGIIAPGSPSPQEMVVVNHFINVQANHSIIAREIAAEGIVLLKNEGLLPLSRSGLDDSKLKIRRKVVERATGKRHTGKFKIGIFGEDAGPGKGPNYCKDRACNQGTLGSGWGSGAVEFPYLITPIEALRREFNASKVELYEYLTNKPAFGSEKAVLDELELCIVFANADSGEGFVSDGDVRGDRPNLNLQKGGDNLIINVASHCGSGVGNVIVVIHSVGPVVMEKWIELPNVKAVLFANLPGQESGNALADVLFGDTNPSGHLPFTIGKSLDDYGPGGKIMYLPNGIVPQQDFSEGLYIDYRYFDKHKIEPRFEFGFGLSYTTFALNNLQVKPRRTKSALPAPRPAPAAQPPSYPTEIPSKSEALFPPGLRRLEKYIYPYLEYVDDIKLGPYPYPDGYDQVQRLSDAGGDEGGNPDLWNVYVDVVVDVTNTGSLAGAVVPQLYLEYPPKDGIDFPVRVLRGFDKVYLEPGQTQTVMFSLTRRDLSYWDVMRQNWVMLTEGEYTFRVGFSSRNLLVWGTCIFLVMTPSKIKLDICRPARAVVVGAGISGLSAAIALRRAGWHVQVLEKSQFKNEIGAAITITPNATLVLDRWGFDMEKAKAVPNQQKLMFMAGSTTVLQHEEYEDLPRTFGHGVWSLHRVDLHRGLRELATCAASDFGRGSKEQTQIMRGPPVDIQLGTQAVGLDCERGAVKLIDGRTVQADLVIVADGAHSRLIADFTGQPSTLKCTGRSVYRWLISMKDIMADPILNSLYTSNRPGFISWLDTHNDIFWVTYQCRRGEVLNVAVVHPTQPGEGDEDHWHCPVSQNQVLSTLANFHPSLQQMVKMANEDGIKVHRLYKRDVLTSFVRGKTAIIGDAAHLMMPTHAAGAGTAIESAAALEILFRGVYAGDEATVGSRLRLFDKLRVPRCNLIMLLSNAGPAGLRVPGVEEEVRKFYSGPLPDRMEKPYSRPFMELLFKHDEFLAAEQLLAEDQQKKDGKDKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0N7</accession>
    <name>G0S0N7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0010680</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691589.1">
        <property type="nucleotide sequence ID" value="XM_006691526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0N7"/>
    <dbReference type="GeneID" id="18255106"/>
    <dbReference type="KEGG" id="cthr:CTHT_0010680"/>
    <dbReference type="HOGENOM" id="CLU_1547370_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="173" mass="19225" checksum="9CA6A51F2FF5CF7D" modified="2011-10-19" version="1">MINMLMGNRKSDSSKDKSSMSMSNDTPKEIMEEQHIYPRKLTRPEASTLKKYDMAISPSQLATLPPGATPTKGVRRRRQHLRPEPELLPMDMVSSGRQREPLRKSEISEMGRAAAKANAGLQGVPGRGELPKREGKGSLWKGERFARGELVPDERAMMGEIPPASVTEVGRKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0V5</accession>
    <name>G0S0V5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0011380</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691657.1">
        <property type="nucleotide sequence ID" value="XM_006691594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0V5"/>
    <dbReference type="STRING" id="759272.G0S0V5"/>
    <dbReference type="GeneID" id="18255176"/>
    <dbReference type="KEGG" id="cthr:CTHT_0011380"/>
    <dbReference type="eggNOG" id="ENOG502SP48">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057546_1_3_1"/>
    <dbReference type="OMA" id="HTIFDFR"/>
    <dbReference type="OrthoDB" id="449382at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF1">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="169"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="319" mass="34943" checksum="BAE9B71552F2C4C4" modified="2011-10-19" version="1">MAIENSGTATPGASNTIQRLPSPPFIHVPGLTNLRDAGGCTLENIPGKAVRRGILFRSAADPCKLDATGVAMLLRLGITHVFDLRSVIELGRSGIQGHGVSGDQGQVHDDQAMCGTGIKRLFVPVFLDKDYSPEALAERFGHYSDGPEGFMKAYATILAAAADPNHPYAPFRTILEHLASRTAPTPVLIHCTAGKDRTGVIIALILALCHVSDETIADEYSLTEIGLASRKEEIIQRLIRPGEALEGDREKAERMVSARKENMLLTLRMIREKYGSVEKYVTEHLGISRESVEQIRRNLIVDVEESSSDKKEREQRPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0Y8</accession>
    <name>G0S0Y8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0011710</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691690.1">
        <property type="nucleotide sequence ID" value="XM_006691627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0Y8"/>
    <dbReference type="STRING" id="759272.G0S0Y8"/>
    <dbReference type="GeneID" id="18255209"/>
    <dbReference type="KEGG" id="cthr:CTHT_0011710"/>
    <dbReference type="eggNOG" id="KOG1991">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004196_0_0_1"/>
    <dbReference type="OMA" id="WVAKTSW"/>
    <dbReference type="OrthoDB" id="760868at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000244">
        <property type="entry name" value="Nonsense-mediated mRNA decay protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF18">
        <property type="entry name" value="D-IMPORTIN 7_RANBP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="11">
        <location>
            <begin position="24"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="914"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="943"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="916"/>
            <end position="927"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS22698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1054" mass="120443" checksum="230501888BF8283A" modified="2011-10-19" version="1">MDATAIRNCIAATLDAEADVRRRAELQLKQAEGQHGFTDCLLDILSSEQEANLHLPTVIYLKNRVNRAWERTDYYPNETLIYEDEKARFRERLLPILASAQNRVRHQLVPILQRILHFDFPEKWPSFMDYTLQLLNTNDPRSVLAGLQCLLAVCRAYRFKASNTESRDHFDKIIEASFPRLLAICNELVNQESDEAGEMLHIALKCYKHATWLELCAYLQQSAVNLGWCSVFLQTVSKPIPASAMQGDPLERERHHWWKAKKWAYFNLNRLYIRHGNPSALDRSVEPASQFVKDFSTQVAPEILKHYLQEIEKWVSKTVWLSRPCLSYTIVFLDECIRPKEMWAHLKPHLTNLVTHFIFPVLCLSEEDIEKFEEEPEEYLHRKLNFYEEVSAPDVSATNFLVTLTKARRKQTFELLSFINDVVNQYEQAPPGQKNHIAKEGALRMIGTLAPVILGKKSPIASQVEYFLVRYVFPDFTSDQGFLRARACDTIEKFEQLDFKDENNLLTVYRHILDCMADPKLPVRVTAALALQPLIRHDIIRTSMQTSIPTIMQQLLKLANEADIDALANVMEDFVEVFAAELTPFAVALSEQLRDTYLRIVRELLENNERRDDLDNEYGDFLDDKSITALGVLQTIGTLILTLESTPDILLHIESVLMPVIQITLENKLYDLFNEVFEIIDSCTFSAKMISPNMWRAFELVHATFKSGAELYLEDMLPALDNFVQYGAPQIIEKPEYVQALYEMVTDMFADGKIGGVDRICACKLAEAMMLSLRGHIDNCVHGFINAAMGVLANQPVLGKSYKVHLMEMVINAIYYNPILSLQVLESQGWTNKFFSLWFSSMSSFTRVHDKQLCILAIIALLSIKPEQVPPSIAVGWPRLLQGIKILFDTLPEAMRNREEALKDDFQFDSGTYGYEESDDEWDDDDANWTGGDNDAEPVTEAKDESTAYLEFLNEEAQKLKADEAEESDDELGEDSVLLESPLDKIDPYLAFRDAFKRLEAEQPQFCASLLSHLSAQEREALAEVCRRADTQDMLGLPSPFPISRARVATNGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0S152</accession>
    <name>G0S152_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative efflux pump protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0012370</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691754.1">
        <property type="nucleotide sequence ID" value="XM_006691691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S152"/>
    <dbReference type="GeneID" id="18255275"/>
    <dbReference type="KEGG" id="cthr:CTHT_0012370"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_25_3_1"/>
    <dbReference type="OMA" id="GHDPVQV"/>
    <dbReference type="OrthoDB" id="4161376at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000784">
        <property type="entry name" value="MFS drug efflux pump"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF109">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="556"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="71"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS22762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="605" mass="65287" checksum="5C85C7B410D590D3" modified="2011-10-19" version="1">MEAHKRPGDHSTVLPPITPTSQSPEHLESPGKLNHAIVIAMPEKRNCGGAAASSREEDQLPMKETFRRWTALTALAFMWTSAQAPLYLFGGAPVYIYRELGGTTYWVWFIAAYLLAAAAISPFVGALSDLFGRRYVAIIGNSVVIVGQIICGTANGMDMFIAGMTVTGVGAGINELTALAGTAELVPVSQRGYYVAGMILTILPFLPCAMYAQLISAYSDWRYIALVTSLWTFIGLILTIAFYFPPGRFKFQGTGEKITFLKRMDLLGGGLSIAGLSLFEAGILGAGYQFPWASAQALVPIIIGGLCLVAFASWEHWAASNPIIPRQPSKAPRTLALTMIIIFISGANFFSVLMLWPGEAYNVYGHNPVGVGVRGMPFAFGTFTGCFISLIFISWFRGHVKWLVFISSVLMTVGCGCLSLARVDNIHAVYGILFIAGLGVGGITVPVSTIATIVCKGEYIATITALTFTVRIVGGAVGYTVYYNVFAHKLVSELKEVLGMECVRLGITNPTLIAQVINLTAASLVKEIRYLPGVNENTWAQLVLAGQTAFSNAYPWAYYCSVGFGAVSVLASLFLEDLTEMMDDSVVAMQWANENRESNQQESSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0S166</accession>
    <name>G0S166_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Malate synthase</fullName>
            <ecNumber evidence="3 10">2.3.3.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0012510</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the malate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.9" evidence="3 10"/>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691768.1">
        <property type="nucleotide sequence ID" value="XM_006691705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S166"/>
    <dbReference type="STRING" id="759272.G0S166"/>
    <dbReference type="GeneID" id="18255289"/>
    <dbReference type="KEGG" id="cthr:CTHT_0012510"/>
    <dbReference type="eggNOG" id="KOG1261">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018928_3_0_1"/>
    <dbReference type="OMA" id="AGCDSCW"/>
    <dbReference type="OrthoDB" id="186072at2759"/>
    <dbReference type="UniPathway" id="UPA00703">
        <property type="reaction ID" value="UER00720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004474">
        <property type="term" value="F:malate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00727">
        <property type="entry name" value="malate_synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1220.12:FF:000001">
        <property type="entry name" value="Malate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.360:FF:000001">
        <property type="entry name" value="Malate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.360">
        <property type="entry name" value="Malate synthase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1220.12">
        <property type="entry name" value="Malate synthase, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044856">
        <property type="entry name" value="Malate_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011076">
        <property type="entry name" value="Malate_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006252">
        <property type="entry name" value="Malate_synthA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019830">
        <property type="entry name" value="Malate_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001465">
        <property type="entry name" value="Malate_synthase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048355">
        <property type="entry name" value="MS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048356">
        <property type="entry name" value="MS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046363">
        <property type="entry name" value="MS_N_TIM-barrel_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01344">
        <property type="entry name" value="malate_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902">
        <property type="entry name" value="MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902:SF1">
        <property type="entry name" value="MALATE SYNTHASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20659">
        <property type="entry name" value="MS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20656">
        <property type="entry name" value="MS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01274">
        <property type="entry name" value="MS_TIM-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001363">
        <property type="entry name" value="Malate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51645">
        <property type="entry name" value="Malate synthase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00510">
        <property type="entry name" value="MALATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Malate synthase N-terminal" evidence="12">
        <location>
            <begin position="10"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Malate synthase TIM barrel" evidence="11">
        <location>
            <begin position="164"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Malate synthase C-terminal" evidence="13">
        <location>
            <begin position="414"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001363-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS22776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="542" mass="61060" checksum="A735A33E730EBB04" modified="2011-10-19" version="1">MATPEVILQGVNVLGPVNDTQRKILTPEALTFLALLHRSFNARRKALLERRKIRQAELDKGVLPDFLPETKHIRDDPTWKGAPPAPGLVDRRVEITGPTDRKMVVNALNADVWTYMADFEDSSAPTWDNMVNGQVNLYDAIRRQIDFKLGNKEYKLRTDRTLPTLIVRPRGWHLEEKHVTVDGEPMSGSLFDFGLYFFHNAKETLKRGFGPYFYLPKMESHLEARLWNDVFNLAQDYIGIPRGTIRATVLIETILAAFEMEEIIYELRDHSAGLNCGRWDYIFSVIKKFRQNPNFVLPDRGQVTMTVPFMDAYVKLLIQTCHKRGVHAMGGMAAQIPIKDDPVANEKALEGVRADKLREVRAGHDGTWVAHPALASVASEVFNKYMPTPNQLFVRREDVKITANDLLNMNVPGKITEDGIKKNLSIGLGYMEAWIRGVGCVPINHLMEDAATAEVSRSQLWQWVRHGVTTAEGKRVDKAYVLKLLKDIAADLAAKAPKGNKYQLAAQYFATQVTGEDYADFLTSLLYDEITSAGSPKPASKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G0S169</accession>
    <name>G0S169_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0012540</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691771.1">
        <property type="nucleotide sequence ID" value="XM_006691708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S169"/>
    <dbReference type="STRING" id="759272.G0S169"/>
    <dbReference type="GeneID" id="18255292"/>
    <dbReference type="KEGG" id="cthr:CTHT_0012540"/>
    <dbReference type="eggNOG" id="KOG0588">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004222_0_0_1"/>
    <dbReference type="OMA" id="THVGPWQ"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005940">
        <property type="term" value="C:septin ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000394">
        <property type="entry name" value="Serine/threonine-protein kinase HSL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.220">
        <property type="entry name" value="Fungal kinase associated-1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031850">
        <property type="entry name" value="Fungal_KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043024">
        <property type="entry name" value="KA1_sf_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16797">
        <property type="entry name" value="Fungal_KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="128"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="602"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="907"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1045"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="628"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="654"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="673"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="685"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="928"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS22779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1232" mass="139873" checksum="6E7E4F4E44CEF51B" modified="2011-10-19" version="1">MDLHSSSGRSISRKPLSDATQRVNYATVANVGRHQTDVDENFASLKSKHISGGRTNPVVSSIYNPSEQRIPQRVQASTHTTTMGTSAYPKLAVVTRDPRDEARRVSQFSNVSSNASTTRQLKTHIGPWQLGKTLGKGSSARVRLARHRVTQQLVAIKIVAKSTAAITQAGSLANLDRIDYRNPKTREDGGLRRMPLAIEREIAILKLIRHPNIIELLDIWENRSEIYLVTEYVEKGDLFEFINWTGPLCEEEAIFYFRQIMTALDYCHSFNICHRDLKPENILLKSNGQIKIADFGMAALQQGPNHQLRTACGSPHYAAPELLRHQYYKGSAVDIWSMGVILYAMLAGRLPFDENDMATMLAKAKRAEYRMPPHLSAEAKDLIGRILVSQPAHRITMKQMWRHSLIKKYDYLEEYMKWDNQPHYGIRNMAAAPIPEEVDIQILRQLRALWHNYTEEELIEKLRQDKPNDYKMFYWLLYNHREAQLENYNNNVPISKSDYHHLKPPGWVKRVTTCQFTEPGRKGYPRTVSKFTVISTVPDVDETGTVKSYDPFNASRIIHPAQASHAKIIIHRNNQESGFNPSPTVVSHSYRSYKSVNGSFKLHSTASSRRTSSADRLRSPYSTMASIRSQQSSVRVRVANRSKRGVDFSNIRNKGQRHRKNRHNALSAPASNKENRDTTERKPDVTSTSQKQASNRVNIANSMVDVPESATSVFAWTEELEELQQCLVKTCDEAFGNSLLSETTTIGVDTRETSPFTLSFGLLEPTGCANYFTPRAQDARPLPPVPANKASTYSGYNSRLQQSPERRVVSEPAYCDSHNNNNNSSSNVRNLSCVHEDQKDKNDWIKQLKAGRDLVPEPLRTPSSRVNKSYDFLSKAENTIRVVDSPSARGFDFTVEVPKPLNIRKVSPASTAAKSPIAQSHEGAQRRVSYNAQDKHPSVSSHPTESNAKKRVSSWFKRTSKHEESNDSGYGAATESSTRSKDALADLDAPRFDRQGSHSSDSGSDLRAPKKKFNLAFWKWSKNTQAAPRMAIIDDYVDDSEWEDEEEVEEPKYIPPLPRAATTRPGKGKGKKKQDDEPQFTSLWSDSELGYRKIEVQQNWLARLFRVKPAMRYMCFTLSKRRARQELVLLLREWRKYGMKSVDVDKERNIIWAHVGPRNYLNIKEVTFAIEIMTVIEHGTRSFLSIARITQEKGAASSFYKVVEAIYDSFSSRGLLVVDKRKINMMIKTLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0S188</accession>
    <name>G0S188_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">G1/S-specific cyclin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0012730</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691790.1">
        <property type="nucleotide sequence ID" value="XM_006691727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S188"/>
    <dbReference type="STRING" id="759272.G0S188"/>
    <dbReference type="GeneID" id="18255311"/>
    <dbReference type="KEGG" id="cthr:CTHT_0012730"/>
    <dbReference type="eggNOG" id="KOG1674">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015683_1_1_1"/>
    <dbReference type="OMA" id="PHVPKHN"/>
    <dbReference type="OrthoDB" id="286814at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF36">
        <property type="entry name" value="PHO85 CYCLIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="482"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="699" mass="76604" checksum="5D5B6BCC6048E380" modified="2011-10-19" version="1">MMSGIYDLTSSLHPLRHAHSNPLLINSSWSSSTTSLTSTSSFWSDVSSQHSDDSISTSDSDSCYFSRAPSSSQQSVSSLGSIYEPAVKLHDPWVRQPVCTQPQVEAPPELRQNPRRTNNSVTSRTGRPPSLVRQDDRKVNFVDNLVDTSTHIVEAIWPTSSVPPRNENGTGSVLPLRTFIQETLRRSRTSYSTLQVALYYLILIKPHVPTHDFTTEQPDDRYSSQAIQCGRRMFLAALILASKYLQDRNYSARAWSKISGLNTQEINKNEMTFLLAVNWKLHVTEEVYKRWCECVAKLTPSQPPSPGGVSMQVYEQQCYNFRRIILGLSPDLSNLEELLAPWSSTLTYLREPSPRTVRRIPSAERFSTFGSDMEQSWSPKSRSVPVVLEPTPANTCAPSRFAPALGLLPTPRLASQPTGLITPAASVVSQVPSRSSSMAFAMAQASASAAAQSADRWPASMGSSPLAPVTRRSSLANSVCSASSPESMISDSSQVSRSSSVSSASSAGAPSSNLDSQARYRTSKSNYDRLGPRLPMKPVYEDNEPICLTSSPEEYGVAVGQEMCDLTLNMLMPCPQREMDNAARTLQNMQQYSSNSPVIGVKAGLKRSRPFSVEDTLQDDVRDILAGRYGSARSWSETMVRSRPDGTRVPQQVPVRISTPGSHKRLCCSAEASQILQIPSLHPAVSGLGGPGMWEGILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1H6</accession>
    <name>G0S1H6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0013630</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EGS22886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691878.1">
        <property type="nucleotide sequence ID" value="XM_006691815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1H6"/>
    <dbReference type="GeneID" id="18255401"/>
    <dbReference type="KEGG" id="cthr:CTHT_0013630"/>
    <dbReference type="HOGENOM" id="CLU_2558112_0_0_1"/>
    <dbReference type="OrthoDB" id="4725400at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS22886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="82" mass="9032" checksum="D41F10B07A235E49" modified="2011-10-19" version="1">MSAPEEDPQIAFDEEDERPYVKSYSKKPKFSVGQRVYLCMNGAYEGPYLVATVAPGKVSLCLGNGLPVLNGKEIDDSYVRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1M8</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">CTHT_0014170</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691930.1">
        <property type="nucleotide sequence ID" value="XM_006691867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1M8"/>
    <dbReference type="GeneID" id="18255455"/>
    <dbReference type="KEGG" id="cthr:CTHT_0014170"/>
    <dbReference type="eggNOG" id="ENOG502R2UZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007593_1_1_1"/>
    <dbReference type="OMA" id="WEMLSSH"/>
    <dbReference type="OrthoDB" id="5945798at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="257"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="618"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="654"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="719"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="524"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="294"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="363"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="400"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="632"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="655"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="744"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="823" mass="90494" checksum="A935164D3B467C8C" modified="2011-10-19" version="1">MQAPRMGRRDVDQLLRASRPITSLSQLSELPQLPQPSCGDPFALSTTPVPAGVLGDLAAGSQVASSPILPSEFYTPATPPQRQRRTIPLSQDSVTSFRRDDPSPTPSSHRTLRRTSGFYSNPSPRPVPLDTPTPSRRPHYLEAAAAAATATVGIHSPRPFLEIPGPYEQPFDPLRRQPSQSSSDDEQPPAERRLSFLEHKRRLAARASPTPQYPSSRLSKHRRSAILWALEDALRQPHPFTPDLEEENASMADLLGANVAPPTTNGQPASSSRPTASPSQTGSPQQVIRGPRVIMRERAEREARQRAEREREQMERARAEEEARLLEDSRRQAEQRPSVAGAGSASDVPPTTDPLTQRRQQRAQESAQASSRLQAGMVSPTQSQPPATVPPLRTRVPATTEPQASTSYPPTSQPDLSTPAPARTGESSHGLGGTRIRNTFPHAFERWEALSAHWEGMTSFWLRRLQENTDEAQRNPIHTQLSRQVADLSAAGANLFHAVVELQRLRASSERKFQRWFFETRAELERHQEVNAMLEAQMEQERQARAEAQAAVAEKEAENKKLQKLLAEMRRELLISKEEARRAWEELGRREQEERDRTLSLQQGHPTLVGGVQVVPMTHGIPSRTTSRHARSQSQATTTSEYAAAQTGQYHEYGAAPAPVVPPSTSAGSDFPGDGYYHRGDPAGHDMADYGAGSDAGYSEGEYMIDACGNYVRDEHGNRIPFHSPSASPSRGGRRTNAPGGSTAAAAADDYLTGRTTPGSSQPPPSSHYPPTSSQWPADPYSGQGYATPGWETMPRHHHPTRLSDVIEEDERSRTSISQVSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0S259</accession>
    <name>G0S259_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0016080</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS23119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692111.1">
        <property type="nucleotide sequence ID" value="XM_006692048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S259"/>
    <dbReference type="GeneID" id="18255646"/>
    <dbReference type="KEGG" id="cthr:CTHT_0016080"/>
    <dbReference type="eggNOG" id="ENOG502QQXP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_289671_0_0_1"/>
    <dbReference type="OMA" id="FEICETK"/>
    <dbReference type="OrthoDB" id="5229017at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="976"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="976"/>
            <end position="993"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1058" mass="117804" checksum="1B4BBAED3E42FF54" modified="2011-10-19" version="1">MDLNDQKVEGEETRYSLFDPNRLSSTTDIRFSIEIFEICETKAVTLSPAKARLIDLCKAEFRDPSEKRTLVGHGKYIQIDHVEDSGQPNVDRYIDDRWEKEKKPVTVGKLKSSDKHSTRKPSLVKLPSLVWNPKTTSKSKFAQEKSEDPKTKPKPKSTGATIPFHEPTAVGRAGLTPYQGQDELMSLEQSRPTRSVPRVLFKMREDAWSMFANPSCDCTCYCGNKPRPRLIFRPDSRDLHRQRLQASASTPAENNFDDSYTFARTSNWVCNLPKDVEPTPVRSRSLADLTNLSTVATMPGNHHQHGDRRGRSRECDHECDHYDGVSDSMLRGNFIPLSNLARSPSPKRDNGVQPSREVPAQNVFVQFNLTDDQVNQIATALSNREDSNDESHPRGRAAQPTTDAARATDNKEVASKSSRAKSPSKAQVRNGSPSRSRARSRSPLKFFNFGNKTPEKGHAKIKTEDVGIGPSSSIKHQKEARFAETDPIPNPKGKQTRHVPPPIDTGLAQAWELEDPGKQPVTIVHNPPECPNEHKRRSTKMRNAPEPALYRMPDDTSSFYSTNTVGERYPSAILPLRIKKEPVTPEEQILLDQLQSQVEFGDIPIRASIRASSPPSQYQYGQFPQEHSHAGAHFQGVKVHPVQHQIVENNNAYIHQSIRPTIQPALLGQNERLNENISTMPSYVDNRTSMQTSKHSFNNLHWSLMSVPLNDAYSPLAQLLGPEYMMTGRVASKVLIGEHGWLEDTSRQVEHVPDANRNSSTGFLGSLVKLAKDFRRSRDSDSKQNSRAMPISMAPREQAIFYSELEWTMSHTVHNFITAQFNAGRLDTEKLRKVAEDWQRRGHSRATGFRFDLETQLELCRLHVGDFQFYNTKHNTSQASLLSVIEANRSNARAFKIRTYVTPDTVIAKWLLDCQSLLNIITVADEPFIELGRLVRFFRRSVEAATTMAKAKDEQSSKIGSDIVGSATATAGSSTAATSTAAGSGNGAPPAATVTGASAASHQAVLGSPIQLRPSHTVGGPVSGNHGHGYGHGQQRQNDGWWNGRGSILDPAEYAEHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2L2</accession>
    <name>G0S2L2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Uric acid-xanthine permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0017620</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692264.1">
        <property type="nucleotide sequence ID" value="XM_006692201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2L2"/>
    <dbReference type="STRING" id="759272.G0S2L2"/>
    <dbReference type="GeneID" id="18255800"/>
    <dbReference type="KEGG" id="cthr:CTHT_0017620"/>
    <dbReference type="eggNOG" id="ENOG502QQD4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017959_7_0_1"/>
    <dbReference type="OMA" id="MVVSMTE"/>
    <dbReference type="OrthoDB" id="1641903at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042907">
        <property type="term" value="F:xanthine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006042">
        <property type="entry name" value="Xan_ur_permease"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00801">
        <property type="entry name" value="ncs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42810">
        <property type="entry name" value="PURINE PERMEASE C1399.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42810:SF2">
        <property type="entry name" value="PURINE PERMEASE C1399.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS22245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="595" mass="62494" checksum="7A2D87DD2234A5C4" modified="2011-10-19" version="1">MDEDQGPSVITPTNSQPAKRSLPARTVEKFRKTFLTKEGLIGNYDYAFLFRPNLPFMKKSDRPAPFFGLNDRMPVLLALILGFQHALAMLAGIITPPIIMSGGGGVNLTADQQQYLVSTALIVSGLLSAIQITRFKLGNTGYYLGTGLISVVGISFAIIPVASGAFAQMYANGFCPVAEDGTKLPCPQGYGAVLGTAAVCALVEIAISFVPPKIILRVFPPIVTGPTVMLIGINLIASGFKNWAGGNGSCYGDNPAPEFVKCPNIYAPHALPWGSPEFLGLGFSVFVTIILCERFGSPIMKSVSVVIGLLTGCIIAAACGYFDHSGIDSAPSASFIWVHTFKLTVYGPLVLPLIAVFIICACEAIGDITATCDVSRLEVDGEIYESRIQGGVLADGINGLLAALCTITPMTTFAQNNGVIALTRCANRSAGYCCCFFLVIMGIFTKFAASLVAIPSAVLGGMTTFLFCSVAVSGMAIIAKNPGPNPFSRRNRFILTAGLALGYGATLVPDYFSHVFTYEGDNKALRGLLDAIELVMETGFAVTAIVTLILNLTLPQDMGDEVVVSAVAPVPEGSTVAAGGSSGRVTPDEKVVKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2W6</accession>
    <name>G0S2W6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tetrahydroxynaphthalene reductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0018740</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692368.1">
        <property type="nucleotide sequence ID" value="XM_006692305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2W6"/>
    <dbReference type="STRING" id="759272.G0S2W6"/>
    <dbReference type="GeneID" id="18255912"/>
    <dbReference type="KEGG" id="cthr:CTHT_0018740"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_1"/>
    <dbReference type="OMA" id="CQKHMVD"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS22349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="268" mass="28496" checksum="C2A847402CB2CC91" modified="2011-10-19" version="1">MVIAIPTASLEGKVALVTGAGRGIGKGIALELARRGASVVVNYVSSAGPAQEVVKEIESYNNGARAIAIQADVSKVSEIHRLFEEAKAAFGRLDIVMSNSGTESWDHVLDVTEEKYDHVFNLNARAQFFVGQAAYKHLEKNGRLILMTSIAAGLMGVKNHALYNSSKMAVIGLVKAFATDFGDKGITVNGIAPGGIKSDMFTQNAWHYIPGGQPDWPAEKIERLMAEHCPLGRCAVPEDVARVVAFLASEDGGWVNGQVITISGGSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0S380</accession>
    <name>G0S380_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0020010</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692482.1">
        <property type="nucleotide sequence ID" value="XM_006692419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S380"/>
    <dbReference type="STRING" id="759272.G0S380"/>
    <dbReference type="GeneID" id="18256039"/>
    <dbReference type="KEGG" id="cthr:CTHT_0020010"/>
    <dbReference type="eggNOG" id="ENOG502RV3A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026590_0_0_1"/>
    <dbReference type="OMA" id="KMSLVTQ"/>
    <dbReference type="OrthoDB" id="5577209at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14364">
        <property type="entry name" value="CUE_ASCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052586">
        <property type="entry name" value="ASCC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041800">
        <property type="entry name" value="ASCC2_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21494:SF0">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21494">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 2 ASC-1 COMPLEX SUBUNIT P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="333"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="689" mass="74258" checksum="4EC12D1FFAB693E3" modified="2011-10-19" version="1">MVSLPSFALFPIATWRDQIVPDEWVSCLNAWAVLVESHLSLPENDFVTVSLKDESLRGFLVSFAREVAANGTACVGPSQSAKRLLKGCLLLVTKILQSPSPPKSLLEWEFLADLSRIYGKKAEPVFSQLSTTARELLDASLSELKKFLIKNLDAGLKGGNLKAIEERLEHVNDLIRVSPAVAEFFLTGSDFLDGLISCYKIANPPLRKALIATTYLCLMGVADGQKLSALSDQLYSLKAAGAAHKSGPLSEDGSLVAELVTSTPLLQRLQHKLNTSESSSRLTSVLKELSSFKKPNSTITKPKRLIRRRIDKGKAPIRSLDSFPSDQQQEDIHLLSLISQVQDLFPDLGAGFIARLLQEYSNSPEQAIAHLLDDSLPPHLASADRSEPLTSFKQPAHPPPHPDTPEFNPADELSDSDIEILTAATQNKLHLGKRRLSASLPAAPSKQTILSALAAFDSDDDERDDTYDAADVGGTIDARPEDAKLVAAETGSLTGVPVDVEMVLARTWLANPGVFARDATTRRSKERAKLREEAGGMTDEAVEGWAVMVQRDDGLRRKVERRYGELGKGAKAHDGAGIQDVIIERTKWRAGDDATEGTEGTEDTEEGEGDEEAGRGAGVRVGVSGAGRGRGRGRGGRGRGGGRGGGGQPSSGGPAVDRRRKEANKASRANHNRRDQRARKMFKGAGLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3N0</accession>
    <name>G0S3N0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0021840</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692653.1">
        <property type="nucleotide sequence ID" value="XM_006692590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3N0"/>
    <dbReference type="STRING" id="759272.G0S3N0"/>
    <dbReference type="GeneID" id="18256222"/>
    <dbReference type="KEGG" id="cthr:CTHT_0021840"/>
    <dbReference type="eggNOG" id="ENOG502SRZH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_417479_0_0_1"/>
    <dbReference type="OMA" id="HEPPNAM"/>
    <dbReference type="OrthoDB" id="3439209at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="462"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS20357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="589" mass="64398" checksum="CC60697A90C6AE95" modified="2011-10-19" version="1">MLMSVARPRRVDVLPPDDDDFDQGTAAGLLSWHFDLSQSINAARILQQRVHQMPFSHIQMKAVGWAESGLKQEEQENQETASYGRPYNTQVLAATMMSNCTSRTSPLSHVSHFSTTTGPRDVCQSSSASVPVSPELLESPYWQGITATGPDSLPFVAPGGEAVWGHAPSILNPPPAFNYGSYTIGVHASMIPQQVFSGIPSVPDSDTTDHGSPDSKLCASSDLLGPIVLDDESSQAWSMSPSETSPALVEGQPGVDVAWDDSATDDKTVSPKMLRLRRSPTPCSVYPEPALLPPAAKVDIALESPKNTLATSKTRKLLQSKSQRTVLPSGSTVLSSSSSKTKGRPSNTRSPSPSLSRKTISKPKSMPRLAPAPRMPPSPTTVAALDPSLPSLRCTSQPFGSEPWSEVPQIKFELSDRMSKDQFLVTKKREGLTYKEIRRMGGFTEAESTLRGRYRTLTKSREARVRKPEWSELDLRLLEKGVRALAHTPDLNSAKVPWKKVAEYIVEHGGSYHFGNSTCRKRWDELVREQMAKGKSINEPFFDDEPARCPADGTTGQKAYWLFALGASEVGHNGGLREGEEEEGEEEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3N3</accession>
    <name>G0S3N3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0021870</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692656.1">
        <property type="nucleotide sequence ID" value="XM_006692593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3N3"/>
    <dbReference type="STRING" id="759272.G0S3N3"/>
    <dbReference type="GeneID" id="18256225"/>
    <dbReference type="KEGG" id="cthr:CTHT_0021870"/>
    <dbReference type="eggNOG" id="KOG0281">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_103_4_1"/>
    <dbReference type="OMA" id="KDISICV"/>
    <dbReference type="OrthoDB" id="19711at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050505">
        <property type="entry name" value="WDR55/POC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019:SF8">
        <property type="entry name" value="POC1 CENTRIOLAR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="6">
        <location>
            <begin position="320"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="422"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="558"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="598"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="638"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="680"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS20360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="780" mass="86906" checksum="A21D81593E2082B1" modified="2011-10-19" version="1">MDSNSRRIVQMHDWAPAHEAMYPAVSSSLPTHSPSPSHLVPPDQAQNHSRLRSMSVSFPWRQRPKSAFFGSVHNNASTSSHNLPLETSKSHGFGALFDQQHTLSQNDPAPTSSKHTHHRDSHLGLKRTLRRMSASLKEGVMGLMHRRTSVPAGTTFDGDGHAVRPHLNLHGNSSARPTTSQSAWHRLRHAASFHHRYSRVLHTGYGDRMFEDDLSTIESPTLPIPGSAEHPPIIPRKTGAAARQAAAIACSGMHGYDVMNVPPMPRPGWLSDDTFDDHESGIGIALTSSEMEAYVPCDGIDSDVDVEASLARDENSIVKVDFISQLPLELSIQILALLDAQTLITASRVCHRWHYVIQNQHIWRESFLREKTQTYATSGPVKPGAGLGVPPIQPSNNWKEIYRVKTELDKRWKEGKARPVYLNGHTDSIYCLQFDEEKIVTGSRDRTIRVWDLHTFACKLIIGPPEIVNDCSYNLLYDEHGQPVHYATVHDPDSPRGPIQAYHSIPALYSPPMHHNASILCLQYDDRILVTGSSDATCIVWTVSGTGSNAGYRPLRRLRHHTAAVLDLVFDEQHIVTCSKDISICVWDRATGALLRQLRGHSGPVNAVQMRGNTIVSCSGDFRVKLWNVDTGKNIREFLGHTKGLACSQFSEDGRYIASAGNDRVIRIWDANTGECVREMKAHENLVRSLHVDSISGRLVSASYDSDIKVWDMETGQPLLDFPKWHSSWVLSAKSDYRRIVSSGQDPKILILDFGAGIKGIEMLESCRRSPNLHEQPGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G0S405</accession>
    <name>G0S405_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Delta(14)-sterol reductase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">C-14 sterol reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Sterol C14-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">CTHT_0022090</name>
    </gene>
    <organism evidence="25">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="26 27 28" key="2">
        <citation type="journal article" date="2025" name="Cell Res." volume="35" first="296" last="308">
            <title>Structural insights into spliceosome fidelity: DHX35-GPATCH1- mediated rejection of aberrant splicing substrates.</title>
            <authorList>
                <person name="Li Y."/>
                <person name="Fischer P."/>
                <person name="Wang M."/>
                <person name="Zhou Q."/>
                <person name="Song A."/>
                <person name="Yuan R."/>
                <person name="Meng W."/>
                <person name="Chen F.X."/>
                <person name="Luhrmann R."/>
                <person name="Lau B."/>
                <person name="Hurt E."/>
                <person name="Cheng J."/>
            </authorList>
            <dbReference type="PubMed" id="40016598"/>
            <dbReference type="DOI" id="10.1038/s41422-025-01084-w"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.80 ANGSTROMS)</scope>
    </reference>
    <comment type="function">
        <text evidence="21">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692677.1">
        <property type="nucleotide sequence ID" value="XM_006692614.1"/>
    </dbReference>
    <dbReference type="PDB" id="9L5R">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="c/m=1-592"/>
    </dbReference>
    <dbReference type="PDB" id="9L5S">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="m=1-592"/>
    </dbReference>
    <dbReference type="PDB" id="9L5T">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.50 A"/>
        <property type="chains" value="m=1-592"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S405"/>
    <dbReference type="EMDB" id="EMD-62841"/>
    <dbReference type="EMDB" id="EMD-62842"/>
    <dbReference type="EMDB" id="EMD-62843"/>
    <dbReference type="SMR" id="G0S405"/>
    <dbReference type="STRING" id="759272.G0S405"/>
    <dbReference type="GeneID" id="18256247"/>
    <dbReference type="KEGG" id="cthr:CTHT_0022090"/>
    <dbReference type="eggNOG" id="KOG1435">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3459">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015631_0_3_1"/>
    <dbReference type="OMA" id="EWCELRP"/>
    <dbReference type="OrthoDB" id="10262235at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050613">
        <property type="term" value="F:Delta14-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01720">
        <property type="entry name" value="Sm_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000018">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027248">
        <property type="entry name" value="Sm_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF52">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE TM7SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="26 27 28" id="KW-0002">3D-structure</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 22" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14 22" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="17" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12 22" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="20 24" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="10 22" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="18 22" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13 22" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="16 22" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="9 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Sm" evidence="23">
        <location>
            <begin position="511"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00058057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU369120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EGS20381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="26">
        <source>
            <dbReference type="PDB" id="9L5R"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="27">
        <source>
            <dbReference type="PDB" id="9L5S"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="28">
        <source>
            <dbReference type="PDB" id="9L5T"/>
        </source>
    </evidence>
    <sequence length="592" mass="66714" checksum="7345678B319B738C" modified="2011-10-19" version="1">MAPKTKKQAVSRTQHYEFFGPPGAAAISFGLPLLVYAFAFACNDITGCPAPSLLHPKSLKLDVLKQEVGWPKNGIWGLASWRVTGWTLAYYLWLALLYRILPGDVVEGTQLRNGGRLKYKLNAFASSMFTLVICAAGTIAQGADFPLWTFIADNYVQILTANVIIAYTLATFVYIRSFSVKPGNPQLRELAVGGVTGNILYDWFIGRELNPRVTLPIIGEIDIKQWMELRPGLLGWTLMNCAFVAKQYRLYGYVTDSIVFVTAVQALYVLDSHYFEPAVLTTIDITTDGFGLMLSFGDIVWVPFIYTQSTRYLAVHPQKLGYLGLVGVTVLLVAGFAIFRLSNSQKNAFRTNPNDPSVKHLKYIETKAGTRLLISGWWGIARHINYLGDWLQAWPYCLPTGLAGYQILTAGSELAEGAVKMLDGRIVVPGEARGWGTIFTYFYVVYFATLLLHRDRRDDEKCSKKYGEDWEKYKEIVRWRIIPALLQKPRSECTEWEIAQIEEWEMANGPLSLLQTAVRSHTQVLISVRSGRKLLARVKAFDRHCNMILENVKEMWTETPVTNGKKGRPVNKDRFISKMFLRGDSVVIVLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0S495</accession>
    <name>G0S495_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Ribosome biogenesis protein NOP53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0039380</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="9 10 11" key="2">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e57984" last="e57984">
            <title>Structural insights into coordinating 5S RNP rotation with ITS2 pre-RNA processing during ribosome formation.</title>
            <authorList>
                <person name="Thoms M."/>
                <person name="Lau B."/>
                <person name="Cheng J."/>
                <person name="Fromm L."/>
                <person name="Denk T."/>
                <person name="Kellner N."/>
                <person name="Flemming D."/>
                <person name="Fischer P."/>
                <person name="Falquet L."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="37921038"/>
            <dbReference type="DOI" id="10.15252/embr.202357984"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.12 ANGSTROMS)</scope>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the NOP53 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS22053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694349.1">
        <property type="nucleotide sequence ID" value="XM_006694286.1"/>
    </dbReference>
    <dbReference type="PDB" id="8PV1">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.56 A"/>
        <property type="chains" value="Ce=1-443"/>
    </dbReference>
    <dbReference type="PDB" id="8PV3">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="Ce=1-443"/>
    </dbReference>
    <dbReference type="PDB" id="8PV4">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="Ce=1-443"/>
    </dbReference>
    <dbReference type="PDB" id="8PV6">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.94 A"/>
        <property type="chains" value="Ce=1-443"/>
    </dbReference>
    <dbReference type="PDB" id="8PV7">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.12 A"/>
        <property type="chains" value="Ce=1-443"/>
    </dbReference>
    <dbReference type="PDB" id="8PVK">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.55 A"/>
        <property type="chains" value="Ce=1-443"/>
    </dbReference>
    <dbReference type="PDB" id="8PVL">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.19 A"/>
        <property type="chains" value="Ce=1-443"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S495"/>
    <dbReference type="EMDB" id="EMD-17950"/>
    <dbReference type="EMDB" id="EMD-17952"/>
    <dbReference type="EMDB" id="EMD-17953"/>
    <dbReference type="EMDB" id="EMD-17955"/>
    <dbReference type="EMDB" id="EMD-17956"/>
    <dbReference type="EMDB" id="EMD-17969"/>
    <dbReference type="EMDB" id="EMD-17970"/>
    <dbReference type="SMR" id="G0S495"/>
    <dbReference type="STRING" id="759272.G0S495"/>
    <dbReference type="GeneID" id="18257976"/>
    <dbReference type="KEGG" id="cthr:CTHT_0039380"/>
    <dbReference type="eggNOG" id="KOG2823">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035888_1_0_1"/>
    <dbReference type="OMA" id="TEKWTHK"/>
    <dbReference type="OrthoDB" id="5072at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011687">
        <property type="entry name" value="Nop53/GLTSCR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211">
        <property type="entry name" value="GLIOMA SUPPRESSOR CANDIDATE REGION GENE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211:SF7">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07767">
        <property type="entry name" value="Nop53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017302">
        <property type="entry name" value="Gltscr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9 10 11" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="161"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="248"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="271"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS22053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="8PV1"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="8PV3"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="8PV4"/>
        </source>
    </evidence>
    <sequence length="443" mass="50880" checksum="9B2BA8E652464BC6" modified="2011-10-19" version="1">MAVLKPLTGDNTEAPKQHSQPSRKGKKAWRKNIDLTEVEQGLEELNEQIIKGGVIAEKPSEELFTIDVEGDASLEKRFSKHIKKGLKADEIIAQRSALPAVSVRKRAGDEPASKVSDGILPVKRQRTNYITHKELIRIKKVADGEHETTVDIVDATYDPWAQDPIEPKKQDPVRPVLPKPDPLKKPKTLEQKPISLAANGKSVPAVPKPTGGYSYNPAFTDYQQRLMEESEKAIEAERKRLQELELERQKMEAAARSAAEAEAAEARAEMSEWEDDSAWEGFESDGEGLNIKAKKPRRKTKAERNRIKRRKEEERKRKHEEAMKRKQQQLEQAKKIAAEVEERERQLALQKIEMSDDSEEGDDTVLRRKQLGKFKLPEKDLELVLPDELEDSLRRLKPEGNLLKDRYRSMIVRGKLEARRKIPFRKQAKTKLTEKWTFKDFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4B1</accession>
    <name>G0S4B1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ABC transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0039540</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
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        </lineage>
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        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS22069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006694302.1"/>
    </dbReference>
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    <dbReference type="STRING" id="759272.G0S4B1"/>
    <dbReference type="GeneID" id="18257992"/>
    <dbReference type="KEGG" id="cthr:CTHT_0039540"/>
    <dbReference type="eggNOG" id="KOG0927">
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    <dbReference type="OMA" id="VRYYMRL"/>
    <dbReference type="OrthoDB" id="10255969at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="Molybdenum_import_ModC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43514">
        <property type="entry name" value="ABC TRANSPORTER I FAMILY MEMBER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43514:SF4">
        <property type="entry name" value="ABC TRANSPORTER I FAMILY MEMBER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="30"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="363"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="671" mass="74819" checksum="85D924B92EAC2B7A" modified="2011-10-19" version="1">MRLPSHTRPPIICIANGTFYRYQPTSHPPIHSQTLLDATVHNHVHPNPPLFKNLNFELPSFSSSPHNWCIIGPSLSGKTTFLQILRGQHLCFPPTARIFPYLSEDEVPARLRTPAKAIGYVGFEGALNLAPETGGPMYLSARYESRREITDFSLRDYLLGNTSLNPGPEIPGSAHISEELFSRVVRDLRLEKLLDLPVTFLSNGQGRRARIARALLTSPEVLLLDEPFMGLDPPTVAGLSQLLKVMAEKRSPRLVLSGRPQDPIPEWVTHMVYLRTDAQIGVMGEREEVLGQLRRYVREVRRGEKKEEEGMPVNALSEMGRVLKEGRVVGEMIGEKGPVLVQAGIDLGQMKPAGEPLVEMAGVRVQYRGKIALGDWENGSQPGGLHWTIRRGERWGVFGPNGSGKTTLVSLLTSDHPQTYSLPIKLFGRSRLPEPGSGERPLTLWDIQARVGHSSPEINAHMPKSLTVRKVLESAWANTFMSKPKLDETATAKVEATLRWFESELNPAYYKRIAAGETHGSIGQSSLAWSSEYLFGELSFSAQRVLLFLRAVVKHPDIVVLDEAFGGMDEAVRDKCMLWLMHGEEKMYKRTGTQIVDSPAAKEGRVNVRGLTDQQALICISHVKEEVPDCVREWLCLPEPNTGRPARFGVLDGPLRRSARRWEEIWGMSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4C2</accession>
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            <fullName evidence="7">EXPERA domain-containing protein</fullName>
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    <organism evidence="9">
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EGS22080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006694313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4C2"/>
    <dbReference type="STRING" id="759272.G0S4C2"/>
    <dbReference type="GeneID" id="18258003"/>
    <dbReference type="KEGG" id="cthr:CTHT_0039650"/>
    <dbReference type="eggNOG" id="ENOG502S97I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086812_2_0_1"/>
    <dbReference type="OMA" id="DWLYLFI"/>
    <dbReference type="OrthoDB" id="433124at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051987">
        <property type="entry name" value="Sigma-2_receptor-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204:SF1">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="7">
        <location>
            <begin position="9"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS22080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="206" mass="23658" checksum="06ED5E474166A222" modified="2011-10-19" version="1">MTTYNTSGRNTLWLVWFLTQLPITAFADLLEFLWPKWMYEPAGSPLHAAFRSKQWYIASFNDPIVQWTPETSAGHDSWMGLFLFLEAAFLLPAILYGLYCFGIRRKGTSGEDELLFFVYALEVWFTTVVCAFDVWNLDSAVWSAEIKHTLVIQFYGPYLVLRKSNVRSRSARTLTQEAALGAIDMGSRILYRIRTADTLLETKKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4K8</accession>
    <name>G0S4K8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6987 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0031360</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006693516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4K8"/>
    <dbReference type="GeneID" id="18257174"/>
    <dbReference type="KEGG" id="cthr:CTHT_0031360"/>
    <dbReference type="eggNOG" id="ENOG502S06V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002822_1_0_1"/>
    <dbReference type="OrthoDB" id="3937590at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022124">
        <property type="entry name" value="DUF3659"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054256">
        <property type="entry name" value="DUF6987"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39461">
        <property type="entry name" value="LEA DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G04920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39461:SF1">
        <property type="entry name" value="LEA DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G04920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12396">
        <property type="entry name" value="DUF3659"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22485">
        <property type="entry name" value="DUF6987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6987" evidence="2">
        <location>
            <begin position="795"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS21283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1012" mass="108761" checksum="F7C2FB2C8BA39FC7" modified="2011-10-19" version="1">MSDIVPETATPGAWPYKGESKEGSAEHSAATPRSSLAASHDVGLCPGEPESGVDMEQGEGEYSHRDIHAERQKLGEAQGEPEMIKVKAGGSVPDVDQETVKMENIQPKPMEEGKGKGKEAVKEQAAADTGNKKSALTGMAKWGFAKAAQNSQVQGAFLKAAKDMFSSTPQLAGKTDHPVELPSQAEREKVTPQRGPSVEEVKDMFSSAPELAGKPDRPVILPIQEETVKKTPASPPSKLEAKDTFSATAELAGETDRPVVPTSELEEQKQAPEISAEEGAAEPLEKPTDVQGESENVIIEPEEKVVQEKEGISEETDETALHAGEHALEEPVSATDKALAKGQNASQSFAYDAEHEGHSAEGEIPAHENHGVEEPIHDQEREREELQVLEPVAEKDSRREGIPEGEKLAPNIHETAQEKSTTCIEKQKADKPLTGEELQEEKATDCSILKNGTVNKGGNVIDEDGKPVGRVTEGVLQQLIGRKVDENGNIWSSSGTILGKAEPIPEDEREILLKEPAPFENFPDAKVSKNGMVISNDEVVGKVVKGDLAIVRGKAVDPDGDILDRSGNVIGHAESWEPEPETEVDKSIMAGKRVNKAGNIVDGSGTIFGRVVEGDVRKMIGRMCDKNGNVLGESGDILGKADLVPEGEREGMKEGPFAELQGSMVVKDGTVITPAGDIVGRLVKGDPKLLFGRQIDEDGDVLDKNGNVIGFAERWEPEKVEKKRSRMYGRRVNREGNVVDEDGNVIGKLTSGDVRICGGKEIDEDGDVVDSKGNIVGHCSLIEDILPEESAEEKEQRKQVEQDKRLATQMAVCIEQCLDSIRPICKLITEKIDRAERMPEDERDEEQLVSDVRPLIEEGGRILSEARGIIKGLDPDGRIAAKAKHRAASREATPEEYHLADVLKDLTGDVTQCIDNAKRKLEDMPYAKKELNPLWGLLNEPLFQILAAVGLLLAGVLNLVGRLLGGLGLGGILDGLLGTLGIGRVLESLGLGSLGKSAKKKGRGLLGGVLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4N4</accession>
    <name>G0S4N4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Oxidoreductase FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0031630</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693605.1">
        <property type="nucleotide sequence ID" value="XM_006693542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4N4"/>
    <dbReference type="STRING" id="759272.G0S4N4"/>
    <dbReference type="GeneID" id="18257201"/>
    <dbReference type="KEGG" id="cthr:CTHT_0031630"/>
    <dbReference type="eggNOG" id="KOG0534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2399467_0_0_1"/>
    <dbReference type="OMA" id="ICERGRG"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF178">
        <property type="entry name" value="CYTOCHROME-B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase FAD/NAD(P)-binding" evidence="7">
        <location>
            <begin position="26"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS21309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="93" mass="10837" checksum="B6E0DC31187622FC" modified="2011-10-19" version="1">MLETTDIRGPKRAIQYKPSGYAKHIGTGVTPMFQMIRSICEDESDPTRLNLLYANNTKADILLREELDGYMKQCPNKFRVHYILMKSLFYMSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G0S518</accession>
    <name>G0S518_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0023760</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692839.1">
        <property type="nucleotide sequence ID" value="XM_006692776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S518"/>
    <dbReference type="STRING" id="759272.G0S518"/>
    <dbReference type="GeneID" id="18256414"/>
    <dbReference type="KEGG" id="cthr:CTHT_0023760"/>
    <dbReference type="eggNOG" id="KOG0616">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_3_1"/>
    <dbReference type="OMA" id="EYGHMFT"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF153">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="208"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="12">
        <location>
            <begin position="446"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="144"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="35"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="73"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="157"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS20543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="501" mass="56587" checksum="324F26A82DFA173B" modified="2011-10-19" version="1">MPLGFLRKKRTRDSKEGISSAPTSPVTPTAKSRFSQSAAVTSSPVAAAASQSVPRSSAASTQQSSGASDTAAEQQQNKPMNTLPVPQSAYQAVSHTPSPGTDPQANLPRIANLINPPQHDIPATYQQQQGVQYVQHVQQPATAGGVVSAQEQKKGEQQQQQQHYHYQQQQQQQQPYHQQQQLQSQQGQLLPQEGQARVTKGKYSLNDFDILRTLGTGSFGRVHLVQSRHNHRFYAIKVLKKAQVVKMKQVEHTNDERRMLSEVKHPFLITLWGTFQDAKNLYMRFPNPVAKFYAAEVTLALEYLHSRNIIYRDLKPENLLLDRHGHLKITDFGFAKRVPDKTWTLCGTPDYLAPEVVSNKGYNKSVDWWSLGILIYEMLCGYTPFWDSGSPMKIYENILRGKVKYPSYLHPDAQNLLERLITADLTKRLGNLYGGSQDVKNHPWFAEVTWDRLARKDIDAPYCPPIKAGMGDASQFDRYPEETEAYGQTGHDEYGYLFPDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G0S564</accession>
    <name>G0S564_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0032400</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693679.1">
        <property type="nucleotide sequence ID" value="XM_006693616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S564"/>
    <dbReference type="GeneID" id="18257278"/>
    <dbReference type="KEGG" id="cthr:CTHT_0032400"/>
    <dbReference type="eggNOG" id="ENOG502S61K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063918_0_0_1"/>
    <dbReference type="OMA" id="PIMPQRQ"/>
    <dbReference type="OrthoDB" id="3877279at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="34702" checksum="3AAA14223EE39D8B" modified="2011-10-19" version="1">MARSPKYSEDSDYDFDEEYFSRTYQPLSNLPTPPPSSKQSLAAQSPRALLEDGGLLDSVLLGPAVHLVNMIPPSASVMEPSVQLVHEMLVRANLPMDVIALAVCILDALNSKFSLNWRLLCPLAKPQQPPSPSGETTTSPSNKRHTLPAAPRGGSSTFVIAPQLHIDAVRPEVIILSALVIAVKFLEDSQSPTHWYASAWGKDMWTCDQINVTERCIMESLGYRIMPLWDATLIADALRDMERAGKQVLNPPRSQRPRSGEVHKRSVSSVETAAAHQQQQKHSHQQQCQRHHHYPQHRQAASGPTPAETPVLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5E4</accession>
    <name>G0S5E4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0024510</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692913.1">
        <property type="nucleotide sequence ID" value="XM_006692850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5E4"/>
    <dbReference type="STRING" id="759272.G0S5E4"/>
    <dbReference type="GeneID" id="18256489"/>
    <dbReference type="KEGG" id="cthr:CTHT_0024510"/>
    <dbReference type="eggNOG" id="ENOG502RJSH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_626990_0_0_1"/>
    <dbReference type="OMA" id="PDPPANC"/>
    <dbReference type="OrthoDB" id="5194044at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="437" mass="45196" checksum="F7E2C4F772EB36BE" modified="2011-10-19" version="1">MSSSRQNLGQGSSSRSSRHRHAHYHTDEEDNSGAGPSGHRTSRGSTAPVSPRSGGSASHRASQDTRESRVSAAAAGAAASDSGVAASGTANNTSNQRGSAADTSSSASSAAAAAVQAVSTNATMPTFQMVAAGGAPPAMPPCPPDPAPLGPPPPPPHPPANPPVINPHGVHFQPQVPSTAMGTVMGKYIPRYDPPAQPQQQGILVNGIPLVGIMGAGGTVTVPVQGVQAVGVAPVTAPVNPIVVQPAPQTMVVQNPAISAPAPVAAPTVASQGMLIQGAAPAAQGNLAFGAQLPAQPPVHVDPALGVGLTPNEQLAENIRLAQSGKAYEPQDFRPADPDPFRLYWFREPDGHWAVFQRRQIERLNARWYRTDEGVFYAVRLPDPPANCPTQDDNGRGVKIGTMAFGVEGWSAGIEIRYCEIGKGMDWVIVYCMNLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5J4</accession>
    <name>G0S5J4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bystin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0033170</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="5 6 7" key="2">
        <citation type="journal article" date="2019" name="Mol. Cell" volume="75" first="1256" last="1269.e7">
            <title>Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration.</title>
            <authorList>
                <person name="Cheng J."/>
                <person name="Bassler J."/>
                <person name="Fischer P."/>
                <person name="Lau B."/>
                <person name="Kellner N."/>
                <person name="Kunze R."/>
                <person name="Griesel S."/>
                <person name="Kallas M."/>
                <person name="Berninghausen O."/>
                <person name="Strauss D."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="31378463"/>
            <dbReference type="DOI" id="10.1016/j.molcel.2019.06.032"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.50 ANGSTROMS)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bystin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693755.1">
        <property type="nucleotide sequence ID" value="XM_006693692.1"/>
    </dbReference>
    <dbReference type="PDB" id="6RXT">
        <property type="method" value="EM"/>
        <property type="resolution" value="7.00 A"/>
        <property type="chains" value="CX=1-480"/>
    </dbReference>
    <dbReference type="PDB" id="6RXU">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.50 A"/>
        <property type="chains" value="CX=1-480"/>
    </dbReference>
    <dbReference type="PDB" id="6RXV">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.00 A"/>
        <property type="chains" value="CX=1-480"/>
    </dbReference>
    <dbReference type="PDB" id="6RXX">
        <property type="method" value="EM"/>
        <property type="resolution" value="7.10 A"/>
        <property type="chains" value="CX=1-480"/>
    </dbReference>
    <dbReference type="PDB" id="6RXY">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.70 A"/>
        <property type="chains" value="CX=1-480"/>
    </dbReference>
    <dbReference type="PDB" id="6RXZ">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.40 A"/>
        <property type="chains" value="CX=1-480"/>
    </dbReference>
    <dbReference type="PDBsum" id="6RXT"/>
    <dbReference type="PDBsum" id="6RXU"/>
    <dbReference type="PDBsum" id="6RXV"/>
    <dbReference type="PDBsum" id="6RXX"/>
    <dbReference type="PDBsum" id="6RXY"/>
    <dbReference type="PDBsum" id="6RXZ"/>
    <dbReference type="AlphaFoldDB" id="G0S5J4"/>
    <dbReference type="EMDB" id="EMD-10051"/>
    <dbReference type="EMDB" id="EMD-10052"/>
    <dbReference type="EMDB" id="EMD-10053"/>
    <dbReference type="EMDB" id="EMD-10054"/>
    <dbReference type="EMDB" id="EMD-10055"/>
    <dbReference type="EMDB" id="EMD-10056"/>
    <dbReference type="SMR" id="G0S5J4"/>
    <dbReference type="STRING" id="759272.G0S5J4"/>
    <dbReference type="GeneID" id="18257355"/>
    <dbReference type="KEGG" id="cthr:CTHT_0033170"/>
    <dbReference type="eggNOG" id="KOG3871">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029727_0_1_1"/>
    <dbReference type="OMA" id="EITRPDK"/>
    <dbReference type="OrthoDB" id="2192561at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007955">
        <property type="entry name" value="Bystin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821:SF0">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05291">
        <property type="entry name" value="Bystin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5 6 7" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="471"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS21459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="6RXT"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="6RXU"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="6RXV"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="480" mass="54248" checksum="A8F388292F9E7FDC" modified="2011-10-19" version="1">MPKAIAASSHKRRHNPLEDDILATGILKNREGRPSKRANKKVAEEENYVDSKASRKILAMSRELMDEEEQQLKNKQVTVASTAFDFDPSRMDHDEDDQEEFVNNEEWGDEDEDAGDNDNEVDAADLEIFNRFVQPTMKDDPLLTHGWDQKPADGEEEKEEQTNLADLILQKIAEKEAMTGGQNGGNPIEEDYEIPPKVVEVFTKIGLILARYKSGPLPKPFKVLPTIPHWEDIIQLTRPDLWTPNACYAATRIFVSAKPQVVQRFMEMIILERVREDIHENKKLNVHLFNCLKKALYKPAGFFKGFLFPLAASGTCTLREAQIISAVLARISIPVLHSAAAIKTLCDIAAEQASQRAECVSATNYLLKVLLEKRYALPWQCIDALVFHFLRYASMAREGDGAPKALPVIFHQCLLVFAQRYRNDITEDQREALLDLLLTHGHEKIAPEIRKELLAGRGRGIPVQQPQPTFDGDDTMLVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G0S634</accession>
    <name>G0S634_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0034020</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693838.1">
        <property type="nucleotide sequence ID" value="XM_006693775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S634"/>
    <dbReference type="GeneID" id="18257440"/>
    <dbReference type="KEGG" id="cthr:CTHT_0034020"/>
    <dbReference type="HOGENOM" id="CLU_868790_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS21542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="320" mass="35313" checksum="866E2A5C5A1D843B" modified="2011-10-19" version="1">MVPVTATLAQAAETSTTKPTVTVTDKVFAMQYSVSSQKESLSPGAIAGITVACAVGIAILFGAILLIRRYVKRARDMAALRRSVRDSLNSPVPPPGTSEIPIATPTVAHDMNASWSAGDASVDTHTTTDSYYKPASRPYRPRRNIHESIALQEPSAFSLAKEQRFRPIAELNGPDLLIYRNKTLEDKNPWWKQRPCGDPRWYEPVTVPNEHVAPNVQLAPVGSSIDEPFPRIQRTILKPQTTIIHDNVPVSRPTPGPKKQRGWPLPEPDSEEETVVPRKGREENTEKAEVGMDKKGKRKVTVEANPRAKGHAIIQPDNFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>G0S663</accession>
    <name>G0S663_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0034320</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Its motor activity is directed toward the microtubule's plus end.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693867.1">
        <property type="nucleotide sequence ID" value="XM_006693804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S663"/>
    <dbReference type="STRING" id="759272.G0S663"/>
    <dbReference type="GeneID" id="18257470"/>
    <dbReference type="KEGG" id="cthr:CTHT_0034320"/>
    <dbReference type="eggNOG" id="KOG0240">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001485_3_0_1"/>
    <dbReference type="OMA" id="FPMGTKQ"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23649">
        <property type="entry name" value="Khc_CBD_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01369">
        <property type="entry name" value="KISc_KHC_KIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000031">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059182">
        <property type="entry name" value="Khc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 10 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="14">
        <location>
            <begin position="8"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="397"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="871"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="440"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="609"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="692"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="760"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="876"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="919"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="89"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS21571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="939" mass="104001" checksum="6F01CF0B7D8262A5" modified="2011-10-19" version="1">MSSNNANNIKVVARFRPQNRVEIEAGGQPVVRFEGQDTCIIDSENAQGTFTFDRVFDMGAKQADIFNYSIKSTVDDILNGYNGTVFAYGQTGAGKSYTMMGSSIDDEEGKGVIPRIVEQIFASILSSPANIEYTVRVSYMEIYMERIRDLLAPHNDNLPVHEEKSRGVYVKGLLEIYVSSVQEVFEVMRRGGQARAVAATNMNQESSRSHSIFVITITQKNVETGSAKSGQLFLVDLAGSEKVGKTGASGQTLEEAKKINKSLSALGMVINALTDGKSTHVPYRDSKLTRILQESLGGNSRTTLIINCSPSSYNDVETLSTLRFGMRAKTIKNKAKVNAELSPAELKSMLAKAKTQITTFENYIASLEGEVQLWRSGETVPKEKWVPPLAEFTTAAKVDSSRTARPSTPSRLLPDRSGAETPTISERAGTPVLPLEKDEREEFLRRENELQDQLAEKETQAATLEKQLRETKEELAALKEHDAKLGKDNERLISECNEIRMQLERLAFENKEAQITMDGLKDANAELTAELDELKQQMLDMKMSAKETSAALDEKEKKKAEKMAKMLAGFDLSGDVFSENERAVADAIAKVDSLYEISNTGDPIPPDELKTLREKLVQTQGIVRQAELQAFSVASNEAAARTRAELEERLATLQQEHEELLSRNLSEADKEEVKALLAKTLSDKSSTQEKLVEELRADLAARTAENERLKTQVEELQRRIKAGAGAMPLINGKTVQQQLAEFDAMKKSLMRDLQNRCERVVELEISLDETREQYNNVLRSSNSRAQQKKMAFLERNLEQLTQVQRQLVEQNSALKKEVAIAERKLIARNERIQSLESLLQESQEKLAQANHKFEVQLAAVKERLEAAKAGSTRGLGSPFAATTTTSSSGGGGFGFSIGSRIAKPLRGGGGDPTVHPTVATIQQQTPVENKRSSWFFQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0S675</accession>
    <name>G0S675_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0025750</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693035.1">
        <property type="nucleotide sequence ID" value="XM_006692972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S675"/>
    <dbReference type="STRING" id="759272.G0S675"/>
    <dbReference type="GeneID" id="18256613"/>
    <dbReference type="KEGG" id="cthr:CTHT_0025750"/>
    <dbReference type="HOGENOM" id="CLU_852587_0_0_1"/>
    <dbReference type="OMA" id="GRNAMGQ"/>
    <dbReference type="OrthoDB" id="5371646at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="326" mass="35666" checksum="2CD43A056C6C3EE7" modified="2011-10-19" version="1">MANHPHSTSSSFQHLREATSSNEPFMDAFSDDEKRFVLAELVKVNQLDVGNLIRFLKDNGVILDQRCLDIQVPRGRNLRQCINAAQAMFDQPQQTPLLVFGEHIQQTPTPIVNPSAKRRSLSDISVPEQSFKKQAVSSTGTMSPRPRPLSASQIPPLGTQHQNIQPRPPNNGWAPPPSAAVRTGITVPPTTTRPRGRPKKAERDNWLISMPTPNSPQPQSPSLRGQPPPQPAPQATGGPGPRVSKLKRRYPPARILSPSEFRAGTKGPSDAITYPNLSSTTESVPSTPAENAVEPTRVNGTSAAKRYTPSNRAANSKRRRFRACQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6Q5</accession>
    <name>G0S6Q5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0035220</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693953.1">
        <property type="nucleotide sequence ID" value="XM_006693890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6Q5"/>
    <dbReference type="SMR" id="G0S6Q5"/>
    <dbReference type="STRING" id="759272.G0S6Q5"/>
    <dbReference type="GeneID" id="18257560"/>
    <dbReference type="KEGG" id="cthr:CTHT_0035220"/>
    <dbReference type="eggNOG" id="KOG0498">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016398_0_0_1"/>
    <dbReference type="OMA" id="ARYMILE"/>
    <dbReference type="OrthoDB" id="447251at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429">
        <property type="entry name" value="PROTEIN TWIN LOV 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429:SF2">
        <property type="entry name" value="PROTEIN TWIN LOV 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0157">Chromophore</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="5">
        <location>
            <begin position="161"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="431"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="529"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="570"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="650"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="431"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="461"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="478"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="572"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="583"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS21657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="791" mass="86026" checksum="0CB8D22048CA4227" modified="2011-10-19" version="1">MTVAPKRGRKPIRESLPQYRSGSRQSASTPANPLTRTNITRNQDTDTLSALVLPRSMDRPLNPVPTTLSSTSLSRIPDFRLNGSYSHLRSDSGLALHTNQAAFRQYTDYNSDGSLTYRPSPPMAISLYEVDSIEEVPTKPPPAVTKVLPPFFDPAMVKLAFSDPITEQRIRRFAEIRHGSADLEFLLQVERCSQTLGDMVSLMTSISSKTFTGAAASPIPSSSLALSPDVASTLKSNTKQCARTALPVLSKLYDDTKAAVEERLARDVYPEFVKYQLAQRMTALLSANSASSAEIKSVYPGLGDAFCMTDPLQPDNPVVYVSDGLLDMTGYRRNAITKKNSRLLQGVATDPLAAQRVSNAISTRREVVELMVNYQSDGTPFWNLLFICPLMERGVIRYFLGAQINVSDSMGTEFKDVMELLKYGASADVCSTSSKPQDSGTQEAQSSSGLEDLSRLDSKPPSRRQRLFQRFRRKSHGSRSNSPSRAACESGSSVQSLLHFFPDSQHQLDEYSTPYSCFLVMRYEASSPAQRTQNQAHNHHNRRVLTRDPPASSRVHLPVAFCSQHARRLLMNNGNGNSSGNGSRHKKHHHQHSRGDEHDEVLGHEVFSILTNTLNSPSITRFFKANILSKMADGEATSLDLMIHCDPGTSAAAHSPPSPLSPTTVIGPGPSENKTTTAVSGSSNVCGSCLAPPSPLKAVVNFSRKGSAPVTSSSTQVVLNEGTGSGGGTCERAEGRPRLSETLDRGAGLVSQVLFGPGRMRRMVSTWVPLKGAEGEVKWVVLVLTTAGTPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0S715</accession>
    <name>G0S715_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0035800</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694009.1">
        <property type="nucleotide sequence ID" value="XM_006693946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S715"/>
    <dbReference type="STRING" id="759272.G0S715"/>
    <dbReference type="GeneID" id="18257618"/>
    <dbReference type="KEGG" id="cthr:CTHT_0035800"/>
    <dbReference type="eggNOG" id="ENOG502S8JK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077442_2_0_1"/>
    <dbReference type="OMA" id="DVWSKPP"/>
    <dbReference type="OrthoDB" id="42525at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009784">
        <property type="entry name" value="DUF1349"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332">
        <property type="entry name" value="REGULATION OF ENOLASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332:SF2">
        <property type="entry name" value="REGULATION OF ENOLASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07081">
        <property type="entry name" value="DUF1349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="207" mass="22890" checksum="45F05C739A6C5A5F" modified="2011-10-19" version="1">MASSTTFSIKAAPGTDIWRKPPSTDVFNAPTSIPPQNQTSSSPLRTKGPLPSFLSARLSFIGSWKYQYDQGGLLLSFRRANFPTTPTKHVGPEKWIKTGVELYNGRPRLSTVACDAWADWSVADLPGNQGDWATVLVERDTDVSGTSLWVYRIDGETGEKVPLREVCWVFGDGDEWEVEVACMAARPGDVGGELAVEFRDFEVTWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0S720</accession>
    <name>G0S720_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0035850</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694014.1">
        <property type="nucleotide sequence ID" value="XM_006693951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S720"/>
    <dbReference type="STRING" id="759272.G0S720"/>
    <dbReference type="GeneID" id="18257623"/>
    <dbReference type="KEGG" id="cthr:CTHT_0035850"/>
    <dbReference type="eggNOG" id="ENOG502RKHA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_759067_0_0_1"/>
    <dbReference type="OrthoDB" id="3542681at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11395">
        <property type="entry name" value="bHLHzip_SREBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052099">
        <property type="entry name" value="Regulatory_TF_Diverse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="3">
        <location>
            <begin position="221"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="253"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS21718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="353" mass="38126" checksum="3F56777175EF1CA8" modified="2011-10-19" version="1">METTTATMRLPGGIDATCGKMALSPLTDSYDYSATGAMVVDTLPWCLPDSPSAYLDDPVCDYASLARGSNSGSVYPNLGPINWTAGYSDPLAGMTYGPPSSLLPPDPFVETDSDGCDQDTFTLTSDPDAPGYIASAEPRSHKRTWSEDSALDSADDRAKAAKAFKSRIPGRRHGVQLRTASRKPRKPSTSSCSSNGSASSMSIKRSPSEEPDDDLTPEERRARRNHNLVEKQYRNRLNAQFERLLAVLPVDQLRGNGSLSGDGKPEGSTIKSSSSHTNEEKRMSKAEVLDLATKRIRALEMDRDRLVRERKEILRNIQLMMAGVAARQQGVGVNVSVGHSVSGMGVVGVKGME</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7A0</accession>
    <name>G0S7A0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0036110</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AFG1 ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694040.1">
        <property type="nucleotide sequence ID" value="XM_006693977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7A0"/>
    <dbReference type="STRING" id="759272.G0S7A0"/>
    <dbReference type="GeneID" id="18257649"/>
    <dbReference type="KEGG" id="cthr:CTHT_0036110"/>
    <dbReference type="eggNOG" id="KOG2383">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008681_1_1_1"/>
    <dbReference type="OMA" id="ARRFINM"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040713">
        <property type="entry name" value="ZapE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169:SF6">
        <property type="entry name" value="AFG1-LIKE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="ATPASE N2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS21744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="553" mass="62178" checksum="1B70717B4157ECE3" modified="2011-10-19" version="1">MRAKLSSLPARSHILLAPRQAAAAGSRCVRRHQLCTSCGHTPASRASGHQSVRLRTVQHSVAPAQFVAGQRRKVSSAAAVAAASVSNGNVGATGPIPEYDRRVANGTLKDDPHQRGIIHNLQNLHEELKGYQAPPVVHPTLESSKPSKSLFSWFRQKKSTSLEIPSNLPKGLYLYGDVGCGKTMLMDLFFDTLPSNIRSKTRIHFHNFMQHVHQRLHQTRLKFGNDVDGVPFVAAEIADQSSVLCFDEFQCTDVADAMILRRLLEALMSHGVVLVTTSNRHPDELYKNGIQRESFIPAIELLKTRLHVINLDSPTDYRKIPRPPSDVYHIGLDAQAIEHAQRWFRFLGDPAQPEPRREVQTVWGREIVVPRVSGRCAWFTFAELIGKPTSAADYLELMRSYDAFIVTEVPGMTYRERDLARRFITFIDAVYESRAKLVLTTAVPLNELFLSRAEVRESLLKSKGKDGQVLDDGAVEDVMNHLMDDLEHNAEQLAKSNLFTGDEEAFAFARALSRLNHMASKEWVERGLHLDQQGSKERESWAKTRSKQLEDRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7B1</accession>
    <name>G0S7B1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF803 domain membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0036220</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694051.1">
        <property type="nucleotide sequence ID" value="XM_006693988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7B1"/>
    <dbReference type="GeneID" id="18257660"/>
    <dbReference type="KEGG" id="cthr:CTHT_0036220"/>
    <dbReference type="eggNOG" id="KOG2922">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012349_5_2_1"/>
    <dbReference type="OMA" id="WSHFPTQ"/>
    <dbReference type="OrthoDB" id="6428174at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF92">
        <property type="entry name" value="SPICHTHYIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="413"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="507"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="643"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="423"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="674"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS21755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="727" mass="79053" checksum="2A690931420B5CD1" modified="2011-10-19" version="1">MDTSSQVISHVHELVTRAGGVSTGEERPPIFKAIGIALAVGSGAFIGTSFVLKKVGLLKANEKYNEVAGEGYGYLKNLYWWAGMILMIIGEGLNFAAYAFTDAILVTPLGALSVVITTILSAIFLKERLSVIGKVACFLCIVGSVVIVMNAPQSSAVANIQQMQKFVIHPLFLSYAGTVIIGSAIVALWLGPKYGNKNMLVYISICSWIGGLSVVATQGLGAAIIAQAQGTPQFNQWFLYVLLVFVIATLLTEIVYLNKALNIFNAAMVTPTYYVYFTSTTIISSAILFRGFKGTPTSIITVVNGFLTICSGVVLLQLSKSAKDVPDAAVFSGDLDQIHTIAEQAQPETEPKADAIRGTAAIIRRLSAAREKMELEELRRLREEKLQESLAPPSETGAPQYEWDGIRRRRTTTFGPRSMTAPSPTPTHLAPPTPHPPLGWSRFPTEEELAQANRPVSPALSSLVGSIRSRARSVLLPGHPDFREQAPHKVQSPMHPVQLTSVAVAGAKPPSIPEYDSDGNGEGSGQGLSYSKRRVQTAGACSRNVSGGSDAGSGRLPPGSPGQSGRRQFSFQNMFKRFHAHEHGGDGAVESGQWFAARGRATPRGYSSPQLKGATEEEMLGLVKNDGNTKRVPAVRVYEYNDDDDDSTEYIDDKKTRYGRGITHGYSQSPPRGEGSEKDEKEKEREELEAYERHRRRFRRNQIESSSDEDEWPSQQPRHEGPGPGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7M9</accession>
    <name>G0S7M9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0036900</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694116.1">
        <property type="nucleotide sequence ID" value="XM_006694053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7M9"/>
    <dbReference type="STRING" id="759272.G0S7M9"/>
    <dbReference type="GeneID" id="18257728"/>
    <dbReference type="KEGG" id="cthr:CTHT_0036900"/>
    <dbReference type="eggNOG" id="ENOG502S0ET">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030669_0_0_1"/>
    <dbReference type="OMA" id="FKAAFPW"/>
    <dbReference type="OrthoDB" id="5346159at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990862">
        <property type="term" value="C:nuclear membrane complex Bqt3-Bqt4"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070197">
        <property type="term" value="P:meiotic attachment of telomere to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044820">
        <property type="term" value="P:mitotic telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.10:FF:000002">
        <property type="entry name" value="APSES transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037548">
        <property type="entry name" value="Bqt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38044">
        <property type="entry name" value="BOUQUET FORMATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38044:SF1">
        <property type="entry name" value="BOUQUET FORMATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0183">Conidiation</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="HTH APSES-type" evidence="7">
        <location>
            <begin position="62"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="161"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="349"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="235"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="279"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="349"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS21820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="438" mass="47580" checksum="8580A9F7513814FB" modified="2011-10-19" version="1">MARTRKLPERRNPLLLENIPPHSELVARRRLGQTILTSRMVQASVPGAEVPESSLGAFDYAHLRAPLPKGIVSGIFKSSPPSYFLMRRSADGYVSATGMFKATFPYAEHEEEEAERRYIKSLPTTSPEETAGNLWIPPEQALQLAEEYQITPWIRALLDPADIQPTPSTDGGPPKKIQAPPKFFFNDSSLAPPTPSTTTRRTRRSASPAKSVTSKRAIATPRRRKVASSQSSVLTEATIASTAESSSPTLVNGELSQASFEFKSSKTEEPSESQAPVESVEKEAQSKEEEPKIKVHVDKDVKVDVDGEEVKRTTVEVEVPIFGKIPSPEDAAKMVAEAKAMVEAAVKADSEAVAAADGPASTKSKSKRKAEDISQGNEDKETEEDAVEPPQAKKVKTEEEIRKEKIKKRAFLGLTATVAVGALGALIPVLTPYVMNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8C6</accession>
    <name>G0S8C6_CHATD</name>
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        <recommendedName>
            <fullName evidence="4">Conidiation-specific protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0021260</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692597.1">
        <property type="nucleotide sequence ID" value="XM_006692534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8C6"/>
    <dbReference type="GeneID" id="18256164"/>
    <dbReference type="KEGG" id="cthr:CTHT_0021260"/>
    <dbReference type="eggNOG" id="ENOG502T63N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1075893_0_0_1"/>
    <dbReference type="OMA" id="GYIPKDC"/>
    <dbReference type="OrthoDB" id="2142213at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408945" description="Conidiation-specific protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="29732" checksum="1205560A638DC508" modified="2011-10-19" version="1">MTSSLLRFIVFTSSFQPVWAAALPPLLPLLSRGDDDTLLANKPSVIPPFPEATQNQDLLRDLHAVDVGYEFWDSDWLPSACVFEANELGFNVTDFQAAEVWYDDCAASWTFCRHKEAVQSWDELLELLSRIPVGLRQYISNFILLPPYTNSLSTKPPMLSAYTRASTIVSSHTHLNLGVLLHEIAHILDTHCPTLQARVIRSGLPPGKTPFSSTPIWQRIVTRDVALPTPYARVSWQESFADAVRWGYYSVAQKSVRSQQDAER</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-03-16" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8G9</accession>
    <name>IF2P_CHATD</name>
    <protein>
        <recommendedName>
            <fullName>Eukaryotic translation initiation factor 5B</fullName>
            <shortName>eIF-5B</shortName>
            <ecNumber evidence="5">3.6.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Translation initiation factor IF-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">CTHT_0029840</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2014" name="EMBO J." volume="33" first="1177" last="1191">
            <title>eIF5B employs a novel domain release mechanism to catalyze ribosomal subunit joining.</title>
            <authorList>
                <person name="Kuhle B."/>
                <person name="Ficner R."/>
            </authorList>
            <dbReference type="PubMed" id="24686316"/>
            <dbReference type="DOI" id="10.1002/embj.201387344"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.87 ANGSTROMS) OF 517-970 IN COMPLEX WITH GDP</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="9 10 11" key="3">
        <citation type="journal article" date="2014" name="EMBO J." volume="33" first="2547" last="2563">
            <title>A monovalent cation acts as structural and catalytic cofactor in translational GTPases.</title>
            <authorList>
                <person name="Kuhle B."/>
                <person name="Ficner R."/>
            </authorList>
            <dbReference type="PubMed" id="25225612"/>
            <dbReference type="DOI" id="10.15252/embj.201488517"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) OF 517-858 IN COMPLEXES WITH GTP; MAGNESIUM; POTASSIUM AND SODIUM</scope>
        <scope>COFACTOR</scope>
        <scope>MUTAGENESIS OF ASP-533</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
    </reference>
    <comment type="function">
        <text evidence="4 5">Plays a role in translation initiation. Translational GTPase that catalyzes the joining of the 40S and 60S subunits to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon. GTP binding and hydrolysis induces conformational changes in the enzyme that renders it active for productive interactions with the ribosome. The release of the enzyme after formation of the initiation complex is a prerequisite to form elongation-competent ribosomes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </cofactor>
        <cofactor evidence="5">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="5">Binds 1 monovalent cation per monomer in the active site, which can be sodium or potassium. This structural cofactor stabilizes the GTP-bound 'on' state, and may also act as a transition state stabilizer of the hydrolysis reaction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="6">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EGS21143" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="5"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21143.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693439.1">
        <property type="nucleotide sequence ID" value="XM_006693376.1"/>
    </dbReference>
    <dbReference type="PDB" id="4N3G">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="A=517-1116"/>
    </dbReference>
    <dbReference type="PDB" id="4N3N">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.75 A"/>
        <property type="chains" value="A=517-1116"/>
    </dbReference>
    <dbReference type="PDB" id="4NCL">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.12 A"/>
        <property type="chains" value="A/B=517-970"/>
    </dbReference>
    <dbReference type="PDB" id="4NCN">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.87 A"/>
        <property type="chains" value="A/B=517-970"/>
    </dbReference>
    <dbReference type="PDB" id="4TMT">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.58 A"/>
        <property type="chains" value="A/B=517-858"/>
    </dbReference>
    <dbReference type="PDB" id="4TMV">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.53 A"/>
        <property type="chains" value="A/B=517-858"/>
    </dbReference>
    <dbReference type="PDB" id="4TMW">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.55 A"/>
        <property type="chains" value="A/B=517-858"/>
    </dbReference>
    <dbReference type="PDB" id="4TMX">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.50 A"/>
        <property type="chains" value="A/B=517-858"/>
    </dbReference>
    <dbReference type="PDB" id="4TMZ">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.28 A"/>
        <property type="chains" value="A/B=517-858"/>
    </dbReference>
    <dbReference type="PDB" id="4TN1">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.75 A"/>
        <property type="chains" value="A/B=517-858"/>
    </dbReference>
    <dbReference type="PDBsum" id="4N3G"/>
    <dbReference type="PDBsum" id="4N3N"/>
    <dbReference type="PDBsum" id="4NCL"/>
    <dbReference type="PDBsum" id="4NCN"/>
    <dbReference type="PDBsum" id="4TMT"/>
    <dbReference type="PDBsum" id="4TMV"/>
    <dbReference type="PDBsum" id="4TMW"/>
    <dbReference type="PDBsum" id="4TMX"/>
    <dbReference type="PDBsum" id="4TMZ"/>
    <dbReference type="PDBsum" id="4TN1"/>
    <dbReference type="AlphaFoldDB" id="G0S8G9"/>
    <dbReference type="SMR" id="G0S8G9"/>
    <dbReference type="STRING" id="759272.G0S8G9"/>
    <dbReference type="GeneID" id="18257022"/>
    <dbReference type="KEGG" id="cthr:CTHT_0029840"/>
    <dbReference type="eggNOG" id="KOG1144">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002656_1_0_1"/>
    <dbReference type="OrthoDB" id="4928at2759"/>
    <dbReference type="EvolutionaryTrace" id="G0S8G9"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03703">
        <property type="entry name" value="aeIF5B_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000026">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000112">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000013">
        <property type="entry name" value="eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029459">
        <property type="entry name" value="EFTU-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003078">
        <property type="entry name" value="PRK04004.1"/>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8K1</accession>
    <name>G0S8K1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0038370</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694257.1">
        <property type="nucleotide sequence ID" value="XM_006694194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8K1"/>
    <dbReference type="STRING" id="759272.G0S8K1"/>
    <dbReference type="GeneID" id="18257875"/>
    <dbReference type="KEGG" id="cthr:CTHT_0038370"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_138_0_1"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="21"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="219"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS21961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="438" mass="50155" checksum="4CEEBFAE24CE73B8" modified="2011-10-19" version="1">MRLLNTETLQVKEFFGFLPPYAILSHTWEKEEVLFSDMQNVSLAHQKAGFVKLQAACQLALKQGYHWIWIDTSCIDKSSSAELSEAINSMYRWYAEFAVCYAYLCDVEYHRLDDIRNSRWFTRGWTLQELIAPTRVEFYDKRWVYIGEKHDDILRSILSQASLVDECVLAGVVSLDRISVARKMYWASRRYTTRKEDEAYCLLGIFDVNMPLLYGEGKKAFIRLQQEIMKATDDQSVLAWYCFDPEELRAMRRNFTNTLPTVLATSPRCFARSRDIWPLTSLFFDPPEKRLRNMDCVGGAVEFSALIDKKSMAGDSGAPELKRVLLNCQMGQIPGTLPIILVDEASGTRYMQPDEVTSTNIYLEVEGKAPPLGVFPESSNPALITSRNALDDRRQSPKVFKEEPIEKNDDSYGVPAANPFSYAIERIKIFKTATYSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>G0S907</accession>
    <name>G0S907_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CTHT_0044110</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694803.1">
        <property type="nucleotide sequence ID" value="XM_006694740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S907"/>
    <dbReference type="STRING" id="759272.G0S907"/>
    <dbReference type="GeneID" id="18258449"/>
    <dbReference type="KEGG" id="cthr:CTHT_0044110"/>
    <dbReference type="eggNOG" id="KOG0578">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_26_1_1"/>
    <dbReference type="OMA" id="MVDIMKF"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019236">
        <property type="term" value="P:response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000011">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000385">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRIB" evidence="16">
        <location>
            <begin position="414"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="756"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="254"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="497"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="645"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="33"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="151"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="348"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="374"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="557"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="609"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="645"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="675"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="703"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="785"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGS19918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1037" mass="114055" checksum="C9F5CF6D1E321EEE" modified="2011-10-19" version="1">MDSPKTGSISSSGGGGGSSHRRKLTKKPPPSHFSHHNHNHNHNHNHNYNHNNHYFHHNHSNRRPQQHDHEQPLGGRRHSSSTFRFGGADNRLDTRSLGSKKSSTSLRQAPSSTPSTPITPHTTNAAPPLPLAFTSSNNKSLAPSVVSTNASDSPSTGLSSFFSSSAARSHTTSTASTTPLYSSQSRPIAASSHLNSSSSVHARTDVQQQLRSDPPPALLPLSSTSSDDLIGDPFDGTALIERIEAIRSSTLLSSSYQSDEHSNGAPNPNNSESHNFDYKNSSSSADGKRSATAAVNNSRPRDPANKERDITQKWQDRPSNSSERSDCHSQARHATTPRTPLMGHSPPTLRQSATFPATTTLPIMTEKGGASKTDAPKRYSDETKESKLPSVLRKKTGFSGFMNSLVGSPKKPIISAPENPVHVTHVGYDSATGQFTGLPKEWQRLLNENGITEKETREHPQVVVDVLTFYKETQEKPPVEQQLEKFHDARVGLLPGHSPLSPLISPPASPRFPNVTQDGSFENPRAPPPVPGKAPAIPAKDLNLMPSRPAPKPPTATAPRTQPTYPTKDSGIGMSQPGEDGAPSYLPPKDNVPMLPEEHRSRSRSNSRANGTSPYMPTQPSPAVTSPTSQTIAYQQQLLQQHQEQAMAQAQAMANGQLGRQLSKRQQPTPPSSQPPHQYGQHHGQIPRTDGQVIPAQQPKLPQQQQQQQQQQQQQQQQQQQHPGARPRHRPRQSNSIDVIAALKRICSEGDPREIYRGFTKIGQGASGGVYTGHERGSNRLVAIKQMNLEQQPKKDLIINEILVMKESSHPNIVNFIDSYLCGGELWVVMEYMEGGSLTDVVTFNIMTEGQIASVCRETLKGLQHLHSKGVIHRDIKSDNILLSMEGNIKLTDFGFCATINEVQNKRTTMVGTPYWMAPEVVTRKEYGRKVDIWSLGIMAIEMIEGEPPYLTESPLRALWLIATNGTPQIKNEHELSPVFRDFLYFALKVDPEKRASAHDLLRHDFMKMCVDLSTLAPLVRAAREARAQERARKGHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0S982</accession>
    <name>G0S982_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Oxidoreductase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0044890</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="5 6 7" key="2">
        <citation type="journal article" date="2022" name="Sci. Adv." volume="8" first="eadc9952" last="eadc9952">
            <title>Conformational changes in mitochondrial complex I of the thermophilic eukaryote &lt;i&gt;Chaetomium thermophilum&lt;/i&gt;.</title>
            <authorList>
                <person name="Laube E."/>
                <person name="Meier-Credo J."/>
                <person name="Langer J.D."/>
                <person name="Kuhlbrandt W."/>
            </authorList>
            <dbReference type="PubMed" id="36427319"/>
            <dbReference type="DOI" id="10.1126/sciadv.adc9952"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.44 ANGSTROMS)</scope>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694878.1">
        <property type="nucleotide sequence ID" value="XM_006694815.1"/>
    </dbReference>
    <dbReference type="PDB" id="7ZM7">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.77 A"/>
        <property type="chains" value="o=1-380"/>
    </dbReference>
    <dbReference type="PDB" id="7ZMB">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.75 A"/>
        <property type="chains" value="o=1-380"/>
    </dbReference>
    <dbReference type="PDB" id="7ZMG">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.44 A"/>
        <property type="chains" value="o=1-380"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S982"/>
    <dbReference type="EMDB" id="EMD-14791"/>
    <dbReference type="EMDB" id="EMD-14794"/>
    <dbReference type="EMDB" id="EMD-14797"/>
    <dbReference type="SMR" id="G0S982"/>
    <dbReference type="STRING" id="759272.G0S982"/>
    <dbReference type="GeneID" id="18258527"/>
    <dbReference type="KEGG" id="cthr:CTHT_0044890"/>
    <dbReference type="eggNOG" id="KOG4690">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062297_2_0_1"/>
    <dbReference type="OrthoDB" id="10064411at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019180">
        <property type="entry name" value="Oxidoreductase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039251">
        <property type="entry name" value="OXLD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21193">
        <property type="entry name" value="OXIDOREDUCTASE-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21193:SF3">
        <property type="entry name" value="OXIDOREDUCTASE-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09791">
        <property type="entry name" value="Oxidored-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5 6 7" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase-like" evidence="2">
        <location>
            <begin position="229"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS19993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="7ZM7"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="7ZMB"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="7ZMG"/>
        </source>
    </evidence>
    <sequence length="380" mass="41556" checksum="CDC37A0386CE9903" modified="2011-10-19" version="1">MRRTILQARPSRVLSRALSSAHGSARPSFAIARSPNEQVFPAGAFYESILRWNPNPVPKPQPIEPPAPEPEPVVEEATPAEPEPVPEPVAEEKTPEPTPAPVEEKSAAPVEAEAEPAPVEEKAAVPEAAPEPEPEPVAEDKPAPEEKKSSRSPKRQQQEESSSAEKPAEKPIRSSGRLDGASAPSPEPQPQDSSQEKPSITFLSGLSGPTSTSSYQSRLESIRSRSRLIAGVLVPPQPTEPDNCCMSGCVNCVWDAYREEMEAWAAAKAEAERRLAAQEVSSVVGTTEESMHAVEDGKRVERTLGVHGEVADRTGDMARELEKGSTSMEEDGAGFGERMEWDEGLYKDVPVGIREFMKQEKRLREERLKRNRKETEHQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9G8</accession>
    <name>G0S9G8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative peroxisomal integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0045840</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694964.1">
        <property type="nucleotide sequence ID" value="XM_006694901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9G8"/>
    <dbReference type="STRING" id="759272.G0S9G8"/>
    <dbReference type="GeneID" id="18258622"/>
    <dbReference type="KEGG" id="cthr:CTHT_0045840"/>
    <dbReference type="eggNOG" id="ENOG502QT80">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016397_1_0_1"/>
    <dbReference type="OMA" id="AWTDERN"/>
    <dbReference type="OrthoDB" id="5586090at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006614">
        <property type="entry name" value="Peroxin/Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052646">
        <property type="entry name" value="Peroxisomal_PEX28-32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31679">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31679:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00693">
        <property type="entry name" value="DysFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Peroxin/Ferlin" evidence="6">
        <location>
            <begin position="414"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="14"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="359"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="546"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="644"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="718"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="363"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="557"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="585"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="653"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="677"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS20079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="739" mass="80250" checksum="72CAC92C3B02387C" modified="2011-10-19" version="1">MAAFDPPFLKHMATARNQRGEPMDASSLRSSSETTRAQNDAGPTTFMGAPTPTYAAFSPTPMPGGSANFAAAAKRRSTILVHQKSPLLLATPPQVTRALAYSHPFILVLNRVLGLITWSSGDPWQSFLMLCGFWIVMILGDKIVQWLTPLLLVFCLIAGMWGRRFSPLSSSSWGEPGPGAGGDSGAAAARRAKNLSVNSVPDKKGGAVGGKTGTPNGHVRNASVADGATARHQKTLDEMVEVLKQFSTRCEILLEPLMELTEFLSTQRTPTSATTRPALIALLVRVFWWLPVWLVLASERVGLITTHRVVLVCGTVLLSWHSRPMRVTRTVLWRSVAVRRLVALVTGLPLDIPGVGMSQHPPAGKATATASTANSTAGKAPADGQTTGLRNHLSQESELTKAIRRTHRREKSTGVRFTFVVYENQRRWFGLGWTNKMLPTERDVWTDEHNNPVPSIDQFELPEVEDGGNVRWQWVEGSRWRVEGVPDEIAMPEDGKGDWDYDKPEAIMGWVFYDNMNGRRGLDGWNRFTRRRKWYRDAELVEIDHTDVDNNATPNPSTDADASTSSDQANTPRPLHTPTASSSSVPTVGRNTPDPSSSDANTPPTPPNQPNREPDDDPIETDSVFSTSSRSLFPFPSLAFRRRVSGMGPMPAGDTASTSSGSMTGTRPQQIPHRRVFSSSSSVGSISGASARSRRTSSAAAEDDAAILGTRARIAVQEAGEGASASSWGIGDDVRMGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9I8</accession>
    <name>G0S9I8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0046040</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694984.1">
        <property type="nucleotide sequence ID" value="XM_006694921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9I8"/>
    <dbReference type="GeneID" id="18258642"/>
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    </dbReference>
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        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:polyphosphate biosynthetic process"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="SPX_YDR089W"/>
        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="487"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="559"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="8">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="200"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="320"/>
            <end position="409"/>
        </location>
    </feature>
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        <location>
            <begin position="200"/>
            <end position="242"/>
        </location>
    </feature>
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        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
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        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
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        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGS20099.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="586" mass="65823" checksum="975C74421B681E4C" modified="2011-10-19" version="1">MKFGQQFEQLSVPRWKLHNIDYNALKQHIKAHTTRDPAVATPVPIPGGGGRDSALIKFENDLYAELCQQHDRVHLFVTSTADEVARRLAHISSVLDRTLARQPSLKRVQRLARCEQELLSCANDVASLKRFVSAQVMAFRKILKKYRKWTGSTALGSRFRDGVLSDPKSFTRRDFNPLQVQCDELLAAMRNAMPADWRKQIATQQQQDQQAQQQLSRTSTSASRTTRASYSRPELSQSQSQPQPEPQPQPAAYWNEYDHGSEAGDVVNGDQNDDSYAIYVNPTDTTLSLPSLDSLRTVFVHPVQRVTSWFTRRRAGGYEYHSAGERGPLLPTSDHQNSHEPQPQAQGYGSTRSASNTLISERSSTSSASSTTSSEDDFPSPFSPRRHPQRQRRRSSSVSDSLISPHDTSHPLRRVEDPFLCRRRILRAWVMLTFSLAGVLALAAVVPLLLLGPYAASSPGEDADEGLDDANDDNEDGSASWQKRQQLLIAVAAVLLAGSLCVNCAGVCLMLWREEWERWEEEQQQGLMMGPQWMVVSGRGLLGRRERRREGSWEMCEKVLGWTVFVLVCVVDVGLLVWLGELVLWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0SA31</accession>
    <name>G0SA31_CHATD</name>
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        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="3" type="ORF">CTHT_0040820</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="332"/>
        </location>
    </feature>
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        <location>
            <begin position="150"/>
            <end position="180"/>
        </location>
    </feature>
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            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGS19603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="369" mass="39871" checksum="7F425C4A72C61F98" modified="2011-10-19" version="1">MVPMARTTELELARPRAADAPRIAAIHLRAMQANPLLWAQFPSEESQHELEKFLTGYYAAFCCGDGTRYGNVGEQVSALAEDQTLISCCRGSTGFGNANVGTGDQTISLTEDENSESCCGGGAGFKKASNEGGDQTLDLVEERQSSSCCGGSTSLKVESKNNSQKLPLAPSQSTEQEPGCADKENGLLVARDSRTGEVVGFVKWDAPNHNKNEADLESTKEKLESGDIRNIEGCRPEYLEGYAMAAEAVRKRAFGDRECYNLNFLCVDPAHQSRGAGTLLTRAVLDRAAHARLPVYLESTESAVRMYERLGFQILDSFDMEIPRRGTSKEGEGGVVGGGFQVYKEWCMVWDPPKVPKATSDDATGTAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>G0SA32</accession>
    <name>G0SA32_CHATD</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0040830</name>
    </gene>
    <organism evidence="3">
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        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="18258121"/>
    <dbReference type="KEGG" id="cthr:CTHT_0040830"/>
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    <dbReference type="Proteomes" id="UP000008066">
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="205" mass="21558" checksum="B7F57CC36EBCED0E" modified="2011-10-19" version="1">MGPGRNGGDGGGRQADTGHFAAGARPQRRADARLICVICTSSGSKARGGGCDVSAVAARATAESSMQSWTKVTSQTQRAPKTPKTIQTPIVFDSPATLDEPAGAKPTGFRNGLAEDIGAPTPVKALAAWRGGGSMGRFMHDTARRGRSAPGEDCANCLRRRRLSPVRFTAVPSFIFHVPDHYRRASFPTIPPDLVASPTAGKYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0SA84</accession>
    <name>G0SA84_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0041350</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006694478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SA84"/>
    <dbReference type="STRING" id="759272.G0SA84"/>
    <dbReference type="GeneID" id="18258173"/>
    <dbReference type="KEGG" id="cthr:CTHT_0041350"/>
    <dbReference type="eggNOG" id="KOG2690">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035242_0_0_1"/>
    <dbReference type="OMA" id="TYYEGAR"/>
    <dbReference type="OrthoDB" id="73788at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3970.10">
        <property type="entry name" value="BSD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051494">
        <property type="entry name" value="BSD_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019:SF5">
        <property type="entry name" value="BSD DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019">
        <property type="entry name" value="SYNAPSE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BSD" evidence="2">
        <location>
            <begin position="280"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS19656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="462" mass="50026" checksum="D3B10CE7D0303923" modified="2011-10-19" version="1">MDIAYDHIQESAFPATTAEDRTISPSGSNDSSDNARKSATQPKSLNEDLQDAYRAFSSSPWGARIGGFLGSVVKQGEAVYREATQELSAVKDDATQGLSSLRQTIINRTRGLSLSTANPFVSTSSSNNDQTSREAGSDDKTPTDETSKQAGTSSSSQEAGSSQATSVLSRLRDEASKRLRDLQRAEDAADEALLRFGSNLRDFLRDAIQIAPPPSDEELSSGSNSPTTRGPGTVLFESKDAQGKRVIHTSRFDAQLHVIHTTKESFMPDGSASGPEFEEWAKGFDIDKKTEDIAADLAKYPELRATMEALVPDKVPYADFWKRYYFLRHGIETAEARRRDLLRAASHEEEIGWDEDSEDEEEEESETETESGSESGSESEDDKKASAGAGVKKRAGSVTSSTTIQPSAKTAEPRKSNDEKSTTGSEASYDVVGAASGVPSQAPNSPKESRKVDDSSSEEDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0SA93</accession>
    <name>G0SA93_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Putative membrane bound hemoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CTHT_0041440</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Microsome membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694550.1">
        <property type="nucleotide sequence ID" value="XM_006694487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SA93"/>
    <dbReference type="STRING" id="759272.G0SA93"/>
    <dbReference type="GeneID" id="18258182"/>
    <dbReference type="KEGG" id="cthr:CTHT_0041440"/>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102602_3_2_1"/>
    <dbReference type="OMA" id="KEFTMQD"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF150">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="15">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGS19665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="136" mass="14642" checksum="B34F3611A87D94FC" modified="2011-10-19" version="1">MSLQLTYQDVAEHNTKNDLYVVIHDKIYDITKFVDEHPGGEEVLLDVAGQDATEAFEDVGHSDEARETLEKLLVGTLKRNPGDPKPKSPKPGAVAPAANNATAGIGVGLYAVMLIGGLIAYFAYNYLQQQQAAQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAL2</accession>
    <name>G0SAL2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0042680</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694669.1">
        <property type="nucleotide sequence ID" value="XM_006694606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAL2"/>
    <dbReference type="GeneID" id="18258306"/>
    <dbReference type="KEGG" id="cthr:CTHT_0042680"/>
    <dbReference type="eggNOG" id="ENOG502RA14">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1299562_0_0_1"/>
    <dbReference type="OMA" id="RWNDGKM"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044688">
        <property type="entry name" value="SCI-1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34117">
        <property type="entry name" value="STYLE CELL-CYCLE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34117:SF1">
        <property type="entry name" value="STYLE CELL-CYCLE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="106"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS19784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="212" mass="24466" checksum="BB59EBE0BB74268A" modified="2011-10-19" version="1">MRAGSPAPSEASDTSSSYGPPPPPGLNRQLSEQQTKPPSFKLSSKQPGPSIPTTADLLIRDADEAAERSAALSASRQMWRLQTKEAVTRTLDNDILLPNRAEPGSRERKLEKRRELNEKLREFRERSPGVGEVDESVLMGGREMDAQEEWREMVRRREERRAEKERRREEVARAKRLEKEEKLREWREKERRVLNQLREIARERFGDGGQAP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2024-05-29" modified="2025-04-09" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAV1</accession>
    <name>NBS1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA repair and telomere maintenance protein NBS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">NBS1</name>
        <name evidence="7" type="ORF">CTHT_0047880</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Mol. Cell" volume="83" first="167" last="185">
            <title>Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the molecular mechanism of scaffolding functions.</title>
            <authorList>
                <person name="Rotheneder M."/>
                <person name="Stakyte K."/>
                <person name="van de Logt E."/>
                <person name="Bartho J.D."/>
                <person name="Lammens K."/>
                <person name="Fan Y."/>
                <person name="Alt A."/>
                <person name="Kessler B."/>
                <person name="Jung C."/>
                <person name="Roos W.P."/>
                <person name="Steigenberger B."/>
                <person name="Hopfner K.P."/>
            </authorList>
            <dbReference type="PubMed" id="36577401"/>
            <dbReference type="DOI" id="10.1016/j.molcel.2022.12.003"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (4.00 ANGSTROMS) IN COMPLEX WITH MRE11 AND RAD50</scope>
        <scope>IDENTIFICATION IN THE MRE11 COMPLEX</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (By similarity). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (By similarity). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (By similarity). The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination (By similarity). Within the MRN complex, NBS1 acts as a protein-protein adapter, which specifically recognizes and binds phosphorylated proteins, promoting their recruitment to DNA damage sites (By similarity). Recruits MRE11 and RAD50 components of the MRN complex to DSBs in response to DNA damage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the MRN complex composed of two heterodimers RAD50 and MRE11 associated with a single NBS1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <text evidence="1">Localizes to DNA double-strand breaks (DSBs).</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The FHA and BRCT domains specifically recognize and bind phosphorylated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the Nibrin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695153.1">
        <property type="nucleotide sequence ID" value="XM_006695090.1"/>
    </dbReference>
    <dbReference type="PDB" id="7ZR1">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.00 A"/>
        <property type="chains" value="E=1-954"/>
    </dbReference>
    <dbReference type="PDBsum" id="7ZR1"/>
    <dbReference type="AlphaFoldDB" id="G0SAV1"/>
    <dbReference type="EMDB" id="EMD-14881"/>
    <dbReference type="SMR" id="G0SAV1"/>
    <dbReference type="STRING" id="759272.G0SAV1"/>
    <dbReference type="GeneID" id="18258826"/>
    <dbReference type="KEGG" id="cthr:CTHT_0047880"/>
    <dbReference type="eggNOG" id="ENOG502QQ7Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007951_0_0_1"/>
    <dbReference type="OMA" id="GIGDHYW"/>
    <dbReference type="OrthoDB" id="552194at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17741">
        <property type="entry name" value="BRCT_nibrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22667">
        <property type="entry name" value="FHA_NBN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10980">
        <property type="entry name" value="Nibrin, BRCT2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040227">
        <property type="entry name" value="Nibrin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032429">
        <property type="entry name" value="Nibrin_BRCT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043014">
        <property type="entry name" value="Nibrin_BRCT2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12162:SF0">
        <property type="entry name" value="NIBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12162">
        <property type="entry name" value="NIBRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16508">
        <property type="entry name" value="NIBRIN_BRCT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0158">Chromosome</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000460317" description="DNA repair and telomere maintenance protein NBS1">
        <location>
            <begin position="1"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="22"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT 1" evidence="1">
        <location>
            <begin position="107"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT 2" evidence="1">
        <location>
            <begin position="244"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="368"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="444"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="528"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="630"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="692"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="378"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="416"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="458"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="541"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="640"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="704"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="726"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="738"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="801"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="826"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="936"/>
            <end position="945"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="O60934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="36577401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="36577401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="EMBL" id="EGS19331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="9">
        <source>
            <dbReference type="PDB" id="7ZR1"/>
        </source>
    </evidence>
    <sequence length="954" mass="105821" checksum="071E21194AD5AAFB" modified="2011-10-19" version="1">MWILESELFDGKRLWLRPGKTYLFGRTVAEAGQLTISDKTVSRKHLTIHIDNVPEGGGRNLRSRSNVIVEDLESKKGTLVNGVQIRGQKTTLTEDVNEIKLGLCPKTLKIRWHPIVLSFSFTSKELRADPWTNLRDSLEQLDIKYSAEYEPTTTHVVSKKRNTSKGLQALINGRYIVTDSFINAIVQATEIPEGEEGASSALEQDFEANWPNPLDHLPPRGEEPGNHTTETYAPDARRQEVFDGYTFIFYEKKQYDNLFPAISAGKGKALLKEVVPNRTRVDEFVRYVKSVAGEKGLGSFEDGSEGKGVVVVRYTPKGEDSAWYAEFFTKFAQQLDHRPIDQKEFLEAILACDASMLRRPLEAMSQPVSVSASVEPQSSEKVRPAVEDRKEVEQSAPKQLQPSAEVPATEESAPAPHRRERRTGRSRFKGFDFDDDDIIIETPQAQSSTQVPALPQVPSASQDSLFVSQREPSLAPSEPMLEEEAPCNTRTTRQTHRKRVLSPLPEHDNSALLDEIAPITAAVKRRRIEAGQDPVPPLPEPEPEREDEDVEMVEESPPRKGKKGAATTAKGKGKKIKQEDEENVLELARRRREEAEAAAAAERQRLAQLGDDDIDYAAIRRLHIIEEIEVRQPEPHGPNRTREQDIADGRWDPRWNGRKNFKRFRRQGETGVRMPVQSVIVPLEEVRTKEYGIGDDYWLEDEEGRVPRRPKETQTQERSTIGSVRDGSGFAAAAASGKGKEKDKENEKEVGRPGSSAAAAKQRSKPAPRRTVLTLDSSDEDEDEPSPHAPGIDTISDSEPEVVSSFPSVIPASEPSRSRAAKAAERANALRSSAHSSQSQTQQHRESQLSTGSSKIQLTLAPGSSSLSFSRSGTAAGRNENGKRPFGSFVSGESTASGRGMSVESGSVRGESASKRQKQGSSGGGSFLATRRKDDGSEEESEDDELKFRFGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAV5</accession>
    <name>G0SAV5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Acetate permease A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0047920</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695157.1">
        <property type="nucleotide sequence ID" value="XM_006695094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAV5"/>
    <dbReference type="STRING" id="759272.G0SAV5"/>
    <dbReference type="GeneID" id="18258830"/>
    <dbReference type="KEGG" id="cthr:CTHT_0047920"/>
    <dbReference type="eggNOG" id="ENOG502QUJS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051062_0_1_1"/>
    <dbReference type="OMA" id="MWEMASG"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047622">
        <property type="entry name" value="GPR1_FUN34_YAAH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038013">
        <property type="entry name" value="AceTr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF1">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01114">
        <property type="entry name" value="GPR1_FUN34_YAAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS19335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="33709" checksum="80833876B6AC00D0" modified="2011-10-19" version="1">MTGQVNPASEKEYVHVTGVNGIDRHDHHGHEHHHHRRPDPHWNPMKNLHKGDEPRLPAFGGEFQPGLWRPIEHRKFANPAPLGLSAFALTTFVLSCVNLNARHVNIPNIAVPLAFGYGGLVQLLAGMWEMAVGNTFGATALSSYGGFWIAYGIMLTPNWNIVGAGGPYQTDAAKAIDPRMTDSALGFFLTGWFIFTTILLLCTLRSTVMFFLLFFSLDLCFLMLACSHYAANNGVETAAHKLTQAGGGFGMVAAFLAWYNAFAGIADSSNSFFLVPVFHFPWSEKGREERLARTATRTEEEDGKGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0SB33</accession>
    <name>G0SB33_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GPI transamidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0048720</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695235.1">
        <property type="nucleotide sequence ID" value="XM_006695172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SB33"/>
    <dbReference type="STRING" id="759272.G0SB33"/>
    <dbReference type="GeneID" id="18258910"/>
    <dbReference type="KEGG" id="cthr:CTHT_0048720"/>
    <dbReference type="eggNOG" id="KOG2632">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3566">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007442_3_1_1"/>
    <dbReference type="OMA" id="THPACTI"/>
    <dbReference type="OrthoDB" id="445301at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000121">
        <property type="entry name" value="GPI transamidase component (GAA1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007246">
        <property type="entry name" value="Gaa1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304:SF0">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04114">
        <property type="entry name" value="Gaa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="629"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="676"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="709"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="795"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="835"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="6">
        <location>
            <begin position="63"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="6">
        <location>
            <begin position="110"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS19413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="867" mass="95935" checksum="7F2F78EA04DF5E9A" modified="2011-10-19" version="1">MPPAPTTLSFNTHRARSYVVRLPLFTRAVLATIILFWILGLQTWWDVRQWGALIPSEISFATLYRMNTFPFIHLNIFHVIMNMLALTPLLERFEAEYGTLTTLALFFGLMGASIWVFLLLGMEAIRTYKTNPYFVLGTHNIPTWTTPILVLFCVSALVPSASFLGHLSGLIVGYVCGFGYVKYLAPPEKILRWIEGKLNLLGRLPHYVSVDQKTYGRFGVLPSTSSPVPPAVGLVQAPLESTPRSKRDNEEVAGLEETGALERRRHDGATTGALRLRRDPRIMKLPPYMSLLFVIVGVVWLLLLPFDQYSRRTYISENALLPGQVHTYFSGSDQNVLRAYKHEVNALVGKSNVQINDKLESILKGIGLKTARQNFTYHAAGHAISGQNLYAILQAPRGDATEAIVLVAAWENAKHEVNRNGIPLALTLLRYFKRWSLWSKDIILVITPDSIAGPQAWVDAYHDAHNPSQVAGLPLKSGALQGAIAIDYAQETRYDSVHIVYDGVNGQLPNLDLINSVVHIARGQMGIGVALQEMWRHTDSYQDRLSTMLRGMLKQGLGLASGPHSSFMPYHVDAVTLQPFGSGWHDEMAMGRVIEGTFRSLNNLLEHLHQSFFFYLLMSRDRFVSIGTYLPSAMLVAASFTIMAIALWVKSGQPEKEDGKESDDKDVSTAVVERDLFLPLGVVILCQSLSIIPLYLFNHASETFLTPSFLFFTLLSTLLPHALSFYLTSARNTPATAQHYHLLKSFSLLLLGMFLSSLATLNFSLSLIIGLLASPLTFLCYPAKTALGRALSMGLLHVLSPTTAVLLVGLAATQSGGLGGVLLEAAKAWHVSGTWTSLVVWCVWWPAWIVGGVVVLGRVGERKVKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>G0SB65</accession>
    <name>G0SB65_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0049060</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695267.1">
        <property type="nucleotide sequence ID" value="XM_006695204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SB65"/>
    <dbReference type="GeneID" id="18258944"/>
    <dbReference type="KEGG" id="cthr:CTHT_0049060"/>
    <dbReference type="HOGENOM" id="CLU_2704600_0_0_1"/>
    <dbReference type="OrthoDB" id="2108802at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS19445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="73" mass="7797" checksum="2F3AD380A1E103A4" modified="2011-10-19" version="1">MLTDWLGHHKDEIVFVKDVTDHAHSLTTACGYALLIGQSNAPDLAENLSSCLDLAVLENCRELSAGGSGVWVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBD2</accession>
    <name>G0SBD2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="18">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CTHT_0049840</name>
    </gene>
    <organism evidence="24">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="function">
        <text evidence="17">This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports the calcium to the vacuole and participates in the control of the cytosolic free calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 18">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="18"/>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695334.1">
        <property type="nucleotide sequence ID" value="XM_006695271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBD2"/>
    <dbReference type="STRING" id="759272.G0SBD2"/>
    <dbReference type="GeneID" id="18259022"/>
    <dbReference type="KEGG" id="cthr:CTHT_0049840"/>
    <dbReference type="eggNOG" id="KOG0204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_9_3_1"/>
    <dbReference type="OMA" id="ISIPWGA"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000039">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000028">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000031">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000018">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 18" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 18" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 18" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="437"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="925"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="962"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1042"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1076"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="22">
        <location>
            <begin position="154"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="20">
        <location>
            <begin position="259"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="21">
        <location>
            <begin position="919"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1138"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00059328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EGS19512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1222" mass="133151" checksum="56FA7DC6A8220298" modified="2011-10-19" version="1">MPSGSEALTSLTTAQPQSNNASERIHASAHPHGPSFRLNPDDALTPDQTNEDMFYNEDDRFAFSPGQLAKLLNPKSLDAFYALGGLRGLEKGLRTNRHTGLSVDETDLEGRIAFEDVAPPKVPKYGAYGNSLPPPKDRLVGKHASPAPTYPAGSQYADRKRVFGINKLPEKKSRSLLELAWITYNDKILILLTIAAVVSLALGLYQTFGVKHEDGGAKVEWVEGVAVIAAILIVVIAGTLNDWQMERSFNKLNKTRGERNVKVIRDGKSVEISVYDVMVGDVMHLFQGDIVPADGIFIDGHGVKCDESSATGESDLLKKVPADEVFEVLERIAKGEPAPESIEKLDPFIISGSQVNEGTGTFLVTAVGVNSSYGRIMMSMQTEQEDTPLQKKLNVLADWIARFGGTAALILFFVLLIKFCAELPGHKGTPAEKGQDFLKLFITAVTVVVVAVPEGLPLAVTLALAFATTRMMKDNNLVRVLRACETMGNATTVCSDKTGTLTQNKMTVVAMTLGRMMSFGGTDPPLDDDTKEKSAPVPITIPNLPSAEFMKRLSTPVKKFLIQSNAVNSTAFEGDGDDGEKTFIGSKTEVALLTLCRDHLGAGPVAEERANANVVQVIPFDSAVKYMATVVKLPNGTYRAYVKGASEILLSKCSRVVEDSSGDEFATAEMTPSIRSELEQTITSYAGQTLRTIGSSYRDFTSWPPRELEGVEEINAAAFDKIHKDMTLVAIYGIKDPLRPQVIEAIQDCRRAGVKVRMVTGDNILTARAIAKECGILSKDGIAMEGPKFRRLPESELRDIVPKLEVLARSSPEDKRILVRTLKDLGETVAVTGDGTNDAPALKMADIGFAMGIAGTEVAKEAAAIILMDDNFASIVKGIAWGRAVNDAVKKFLQFQLTVNVTAVVLTFVSSVASAREESVLKAVQLLWVNLIMDTLAALALATDPPSKSILDRKPDKKSDSLITTGMAKMIIGQAICQLAITLVLNFAGAKLLGYDTSIKHEATRLNTLIFNTFVWLQIFNELNNRRLDSNPNIFEGITRNMWFICINLIMIGGQILIIFVGGRAFQIVRLNGKEWGLSVGLGAISLPWGALIRLFPDEWARKLVPPMPAFIKKWQEKRQEKKLLKLKQRAVTDLEAGATATTATSTDHEREKPEPIAPVAYTGTGAGSRPVLRSSGTFQSLPEEYLRPQRSLTVSLIRGKRAETHISDHLRGRRSFRRSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBE8</accession>
    <name>G0SBE8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Altered inheritance of mitochondria protein 24, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0050020</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the AIM24 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695350.1">
        <property type="nucleotide sequence ID" value="XM_006695287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBE8"/>
    <dbReference type="GeneID" id="18259040"/>
    <dbReference type="KEGG" id="cthr:CTHT_0050020"/>
    <dbReference type="eggNOG" id="ENOG502RXC5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046558_0_0_1"/>
    <dbReference type="OMA" id="QTRCVQI"/>
    <dbReference type="OrthoDB" id="5295771at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="entry name" value="Mitochondrial biogenesis AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36959">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36959:SF2">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="TRAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS19528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="373" mass="41416" checksum="8716059D21EC58BF" modified="2011-10-19" version="1">MSRITWARSLRPVSSPSPTLLSLWAPTSFRGQFVCRQCRAKSIHIEAAAATETEKTRETLRRDLYEYGGLGSADARFEVLGSPYSILSVQSTLSLLSPIPRALLGIPFLYQRIISTTPINALISTKSPNTTLSILHLDGTTDWIVANRSALLAWTGHTLTLTPCVQTGLTLAHWGNTRLTGRGLAALAAPGQVYEMKLSEGEELVLHPSHVVAYTVTKNPPLPFRFKSTMFTLTIPTLPPVVRTAAGKMIPEGWSRFWAAMRDTVTYKLLSRVFFSLRTAARTTIWGDRLFLQFKGPTTILMSSQGARVRDVLTREHVNEIAEVEPGAVQIAAELPVKESEEKQEMVRVRIARVGKEGKVTFEDVRDLNEFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBN5</accession>
    <name>G0SBN5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tubulin-specific chaperone A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0054210</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the TBCA family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695756.1">
        <property type="nucleotide sequence ID" value="XM_006695693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBN5"/>
    <dbReference type="STRING" id="759272.G0SBN5"/>
    <dbReference type="GeneID" id="18259459"/>
    <dbReference type="KEGG" id="cthr:CTHT_0054210"/>
    <dbReference type="eggNOG" id="KOG3470">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130569_0_1_1"/>
    <dbReference type="OMA" id="DENREYM"/>
    <dbReference type="OrthoDB" id="296187at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004226">
        <property type="entry name" value="TBCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036126">
        <property type="entry name" value="TBCA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21500">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21500:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02970">
        <property type="entry name" value="TBCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46988">
        <property type="entry name" value="Tubulin chaperone cofactor A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS18811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="137" mass="15210" checksum="0A6CEEA96FDE4984" modified="2011-10-19" version="1">MAPPSPLVIATQALNRLVKEESYYHKELASQEKRIKKLEDDIASNSPDLDSNAEYILKQEKKALEETKAVFEPLRKRIAAAIDKLEEQIAIAESAGNAPAEELKKAKEALGAAQKVLEQKEEKPKEEEGKGGDKEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBP5</accession>
    <name>G0SBP5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0054310</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695766.1">
        <property type="nucleotide sequence ID" value="XM_006695703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBP5"/>
    <dbReference type="STRING" id="759272.G0SBP5"/>
    <dbReference type="GeneID" id="18259469"/>
    <dbReference type="KEGG" id="cthr:CTHT_0054310"/>
    <dbReference type="eggNOG" id="ENOG502QQWJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1510422_0_0_1"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052811">
        <property type="entry name" value="Glucose_resp_signaling"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47263">
        <property type="entry name" value="ADENYLATE CYCLASE ACTIVATION PROTEIN GIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47263:SF1">
        <property type="entry name" value="C2 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G02350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS18821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="178" mass="20018" checksum="E942EB484DAAC157" modified="2011-10-19" version="1">MSTPSRSSYHLRLGSVHGDFYDGRSSRSRAPPVSYEDAYSYALRVAFLRYILQPRKKRKEYVAAPKRLQRAHSSSISELVKEIGPSGHPAAKLPSNFSRTLAKRMSGVVTGAEKLPGYNDASLKRSFAEAYTAFTAKEFQKSLDKDRKVEDLVLIFYSAATKAQGRGRPPMITRGRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBQ9</accession>
    <name>G0SBQ9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0054450</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ARS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695780.1">
        <property type="nucleotide sequence ID" value="XM_006695717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBQ9"/>
    <dbReference type="STRING" id="759272.G0SBQ9"/>
    <dbReference type="GeneID" id="18259483"/>
    <dbReference type="KEGG" id="cthr:CTHT_0054450"/>
    <dbReference type="eggNOG" id="KOG2295">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014487_0_0_1"/>
    <dbReference type="OMA" id="FEDKIMQ"/>
    <dbReference type="OrthoDB" id="342064at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025239">
        <property type="entry name" value="DUF4187"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039727">
        <property type="entry name" value="SE/Ars2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007042">
        <property type="entry name" value="SERRATE/Ars2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021933">
        <property type="entry name" value="SERRATE/Ars2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13165">
        <property type="entry name" value="ARSENITE-RESISTANCE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13165:SF0">
        <property type="entry name" value="SERRATE RNA EFFECTOR MOLECULE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04959">
        <property type="entry name" value="ARS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13821">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12066">
        <property type="entry name" value="SERRATE_Ars2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01173">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="675"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="341"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="578"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="723"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="789"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="353"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="595"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="736"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="841"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="899"/>
            <end position="908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS18835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="908" mass="101957" checksum="B4BD038CEEBCD1D7" modified="2011-10-19" version="1">MDPHHYRDSVRSPGDRDRGWSSRDDRLKDERGDRDRDYYRSRSPGTERSRRRSRSPVAVDRYEPRGRGRDDYAAPRDRDDRRRIGSPPANIDRYVPGQDPLPPPPLTNPIPDPLKLPYQVGFSYFGEWWRANERIKEEKERLRTGRRREPERVRTQEDREKEKAKIQAAYDAYKEELQAKMAQSFVKQHKEDQWFRERYVPEVRDALRQKLNEMRREAYARWEQDLASGVFDDFTLEGIPKNESNGAGGVVEKEEGETTAANEVLGVGDLVPANPNEIRDESLYQPTLLIKTIAPSVSRQNLENFCKEHLGEGEGGFKWLSLSDPNPSKRFHRIGWIILNPASEPPAEADPEEAGKDEQEDGESKPKPRTIAEKALEAINGKTVKDEQRGDFTCHVGVHNPPANPRKKALWDLFSHPDRIRKDLQLATELVNKYESDFGSDFNAVLQIEEYVEKLRSEGKLEPAVPTSPVKKTKKERIVDSTDDALDKEVEEGDASIVGGEDEDEDEGVVDDEVDDIDLLVTKKKLDLTIEYLRRVFNFCFFCVFESDSVHELTRKCPGGHLRRPRSTLSSAAKIVAQASAAGEPFPSRKRKESEEVEEGEATEPEQRKFRASSKTEQQLQRAYNWVKTFEDKINQILHPESVDIRKLGGKPVEDAVHDELSKYVKQEDEHKWRCKIPECTKLFKEEHFWRKHVEKRHTEWLDKLKEEFELINAYVLDPAHIAPSRTDANSNGHFPQPNGQQPTGTPRGFNLQNYAMNNMINFAGFPMSMFQQNMLGGANPLGSQAWHHAGAASAGGSGGHDDRGGGGPAGPIRRGGPAGGAGSSGRYNSRVGPYDRRGGRWGGGEAGGMNGGGGRGGRGGGGFSNRWGDGVAGGGAMAPREAVQGRTIKSYEDLDQVSGGGGGELNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBS6</accession>
    <name>G0SBS6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0054630</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695797.1">
        <property type="nucleotide sequence ID" value="XM_006695734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBS6"/>
    <dbReference type="STRING" id="759272.G0SBS6"/>
    <dbReference type="GeneID" id="18259501"/>
    <dbReference type="KEGG" id="cthr:CTHT_0054630"/>
    <dbReference type="eggNOG" id="ENOG502QV88">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011273_0_0_1"/>
    <dbReference type="OMA" id="LNGWGIE"/>
    <dbReference type="OrthoDB" id="2384430at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052945">
        <property type="entry name" value="Mitotic_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628:SF11">
        <property type="entry name" value="PROTEIN DSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="715"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="509"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="719"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="731"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="746" mass="81471" checksum="CBD6F0CA21E030F5" modified="2011-10-19" version="1">MSSNRPDALDLRSKSQASISRPLRSPRLHVAGEIPPERSPLEELVHHTVLLQRQLEESAKNGRRISRLPPLTPESPLIVQTRSEYYRSRSQDSHHNDDDDHSVLDRHDNGNSNHLGLGLRTEEVDVNNRPRSVHPTLGQIDPVTDQSIPVPAIPTQFMDSSRGRQPSDAGENGGYFGVGARREQSPGPIERKPSDLEKVITNQSGATANHDGSQKPSPSPATGPCLTNSPERYGGKSSFDGGNLVPPRPLFTKRSSSLQSSPLESTDEEFNSSLSTSMHSQSSRKFSTSSGVMSPAYGSFGRSPSSASDASILPRPTFNFSRPLSRAGTPSFDTRPDMVAPPARQASCDSHTSFLPEENVCTPVSTRSEANREINGDNETSPAPSHIYSKFNLPRGKSVQRNIFEDMNGASSSLDEQVPSSPTQKSSTYPLVGQPPPSPPTRPSSSGGVRQTDDENARRPSSERSKLHDVPACLRPAQQPSPNPSRPSTDDTRPSMDEPRGRSTAPRPSLSAATSDSASTIKPSHHSSNPVGPAMAELSAEEHVSKAIALHENGSLQESTWHLQHAAKMGHPTGMLLYALACRHGWGMRPNPREGVEWLRRAAESAHLEIAEDEEMVKEGKHVDSAERKTRKAQFALSIYELGVSHMNGWGVEQDKALALRCFEIAASWGDVDAMAEAGFCYAQGIGCKKDLKKSAKYYREAEARGMSMVGNSWIHKPKYADDPPKDQQRSKSRTRKSIFSRRKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>G0SC72</accession>
    <name>G0SC72_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0056180</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695943.1">
        <property type="nucleotide sequence ID" value="XM_006695880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SC72"/>
    <dbReference type="GeneID" id="18259656"/>
    <dbReference type="KEGG" id="cthr:CTHT_0056180"/>
    <dbReference type="HOGENOM" id="CLU_1156266_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="240" mass="25885" checksum="6EE0F0D19A0ABC22" modified="2011-10-19" version="1">MGQEKVGSPVHIQVVLGRHEGWKESPATTHFAAWRPGALVPVEHGTIDEWSEPVENSEPCPSAGGVPFDGSSLNGRGRSAPLKPQLGSVLWFVNGYVPFWARSSFLALPHSGHPRNLWLTLTGGGRLSVEATPALGVAKSEMIQVLAFLGTTNFTLHTQFGNVVVWLARAASQHLMQDDAAICPDVACPDIPDPDSTVPERWVSPSLIERVKMEPAGLYSGPKARANEANQARNTSPREM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G0SC90</accession>
    <name>G0SC90_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyltransferase 2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0056360</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695961.1">
        <property type="nucleotide sequence ID" value="XM_006695898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SC90"/>
    <dbReference type="GeneID" id="18259674"/>
    <dbReference type="KEGG" id="cthr:CTHT_0056360"/>
    <dbReference type="eggNOG" id="ENOG502QTTH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014663_0_0_1"/>
    <dbReference type="OMA" id="WRTELRY"/>
    <dbReference type="OrthoDB" id="5819478at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36851:SF1">
        <property type="entry name" value="GLYCO_TRANS_2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36851">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="43791" checksum="84E9DA67B02B1FB2" modified="2011-10-19" version="1">MISLLHEGFNSSSDGDSMDTDYTELGLSDGVIHAIIIPNYNEDIDTLRETLEVLASHPQASTAYDIYLAMEEREPNAEAKVVTLINSFVNKFHFITFTLHPTDLPGELPGKGSNMAWAARKLSERHLSSSYFSYLTTLHLSHPKTARTTFYTPPIISDRNSHTVASFVRVADILWSAAGMSNLYPGSTVAPPISVYSLPLELVDRVGGGAKYVNPGTCAKNDIPSGIVTDTLPSPNWFRIAILLHRLFEAHFLPAQMIIIVITSMLYVRLTDSNTSDPHNVAWVFVLCSTLRTLGFLEIALYLFLYEDFHALCVEAREKEMREAGLVGAMSFSRREWKRNWVDYFVAPVVAPLFGSVPAVQAQVLHFWRTELRYEVSRKVVRSERSGEDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCE6</accession>
    <name>G0SCE6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein phosphatase 1 regulatory subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0056940</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696017.1">
        <property type="nucleotide sequence ID" value="XM_006695954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCE6"/>
    <dbReference type="STRING" id="759272.G0SCE6"/>
    <dbReference type="GeneID" id="18259732"/>
    <dbReference type="KEGG" id="cthr:CTHT_0056940"/>
    <dbReference type="eggNOG" id="KOG0531">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044236_0_1_1"/>
    <dbReference type="OMA" id="EVWASYN"/>
    <dbReference type="OrthoDB" id="266138at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000446">
        <property type="entry name" value="Protein phosphatase 1 regulatory subunit SDS22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050836">
        <property type="entry name" value="SDS22/Internalin_LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="32"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS19072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="397" mass="45129" checksum="25252FDEAD6E0BA5" modified="2011-10-19" version="1">MPAPTEEETPQTQPQQTQPSQPSQQSQQSQGHHIELPAESETPKHEGEGSTELKDHKGWDGKARVSKSATLKNPEALSDPEYSDEDNVVPGEQIEADEDLLDEEDPETDEIICTHARIRSIPALRLERFKNLQRLCLRQNLIQEIEGLDGIADTIQELDLYDNLISHVRGLDKLVNLTSLDLSFNKIKHIKHVNHLTNLTDLFFVANKISKIENLEGLTKLRNLELGSNRIRELQNLSHLTALEELWVAKNKITSLNGLAGLNNLRLLSIQSNRIRDLSPLKDIPQLEELYISHNGIESLEGISHNTRLRVLEVSSNRITSLKGIGPLKQLEEFWASYNQLGDWTEVERELADKENLTTVYFEGNPLQTRQPALYRNKVRLLLPQVRQIDATMTRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCN0</accession>
    <name>G0SCN0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Cytidine deaminase</fullName>
            <ecNumber evidence="4 13">3.5.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 13">Cytidine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0057810</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2'-deoxycytidine + H2O + H(+) = 2'-deoxyuridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13433"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15698"/>
            <dbReference type="ChEBI" id="CHEBI:16450"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 13">
            <text>cytidine + H2O + H(+) = uridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16069"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.5" evidence="4 13"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696101.1">
        <property type="nucleotide sequence ID" value="XM_006696038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCN0"/>
    <dbReference type="SMR" id="G0SCN0"/>
    <dbReference type="STRING" id="759272.G0SCN0"/>
    <dbReference type="GeneID" id="18259819"/>
    <dbReference type="KEGG" id="cthr:CTHT_0057810"/>
    <dbReference type="eggNOG" id="KOG0833">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097262_2_2_1"/>
    <dbReference type="OMA" id="LTHFTCV"/>
    <dbReference type="OrthoDB" id="414540at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055086">
        <property type="term" value="P:nucleobase-containing small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072527">
        <property type="term" value="P:pyrimidine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01283">
        <property type="entry name" value="cytidine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000008">
        <property type="entry name" value="Cytidine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050202">
        <property type="entry name" value="Cyt/Deoxycyt_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006262">
        <property type="entry name" value="Cyt_deam_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01354">
        <property type="entry name" value="cyt_deam_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004064">
        <property type="entry name" value="PRK05578.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644:SF2">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="14">
        <location>
            <begin position="29"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="73"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS19156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="183" mass="19718" checksum="A28C6FA58541B110" modified="2011-10-19" version="1">MAPPNVEIYLSSTQCQHPAPYQAFGLTYENFHSLHTAANEAKSRAYCPYSKFRVGAALLISKNSDVEVIAGCNVENAAYPVGTCAERVAFGNAVANGILKPGQQDGGIVKAVAVITDVEVDMEKGTMPASPCGMCRQFIREFCDLNVPIIMFDKNGNYAIMRLEELLPLSFGPENLGVPGPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCN3</accession>
    <name>G0SCN3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0057840</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696104.1">
        <property type="nucleotide sequence ID" value="XM_006696041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCN3"/>
    <dbReference type="GeneID" id="18259822"/>
    <dbReference type="KEGG" id="cthr:CTHT_0057840"/>
    <dbReference type="HOGENOM" id="CLU_1390064_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="196" mass="22971" checksum="380E645B5CC9C60C" modified="2011-10-19" version="1">MCLFKICITVRPKCRHKQHRSRRHSSHRHPDLSGRDRCYERSYRDWEDEKEVVEHDEGNDSGIEIIQEQECLLEEARAKRYQRRSKYTDSDKKRDRKHEKRVTWEDEEYADEKPAQRGTPGLPAANSGIARLEGNWNNRNSGYSGNRCTCCGHCSYYRTSYVAPDTRPSWPGIPELDDPREPLPATRPPPPYTSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCW1</accession>
    <name>G0SCW1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable lysosomal cobalamin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0058570</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LIMR family. LMBRD1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696177.1">
        <property type="nucleotide sequence ID" value="XM_006696114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCW1"/>
    <dbReference type="STRING" id="759272.G0SCW1"/>
    <dbReference type="GeneID" id="18259895"/>
    <dbReference type="KEGG" id="cthr:CTHT_0058570"/>
    <dbReference type="eggNOG" id="ENOG502QQ2T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028341_1_0_1"/>
    <dbReference type="OMA" id="FWAQFVF"/>
    <dbReference type="OrthoDB" id="73273at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072665">
        <property type="term" value="P:protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050854">
        <property type="entry name" value="LMBD1_LysCbl_Transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006876">
        <property type="entry name" value="LMBR1-like_membr_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16130:SF2">
        <property type="entry name" value="LYSOSOMAL COBALAMIN TRANSPORT ESCORT PROTEIN LMBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16130">
        <property type="entry name" value="LYSOSOMAL COBALAMIN TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04791">
        <property type="entry name" value="LMBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="10" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="420"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="576"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS19232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="598" mass="66529" checksum="C67D0D48A6B6D798" modified="2011-10-19" version="1">MKADVLQTSLIWTAYGVAVVLVLLVAVITTYTWQSPHERSIVTNLVSTVSITALLATVFLLPVDIALVSSTGSVHLGAKKEWATPERVEGILRTLEIVYYTLYSFDALLCLIFIPFAYFWYEEHDEVEEEEGTTTKVTRFWHALRYTLAFAFMVVILFLIGFFVPAAGNSHRPHMDLDYFKRLLAANNGEKALTFGVGLLMTLGTLLYILYTGAGMALLPVSAIKSAPSISAPQLSATTATALERNRERQRQLEMRNTGRPGGMSSKDRRELDALLREERTLVRRQRLAAEARGDGRGYIYWVWTKLEAVFRPLKLLGGILLLLVALVVWVSMLITAIDKAANSVCKQHCGYILGHLNVFQPVNWIFVQAAKVFPVDYILMAFIILLFFSSSITGLASIGIRFLWVRIFQIRKGRTAPQALLMATIMLALIILAINYAVAMLAAPQYAIYGTQTFCVNRPALPGLQPDCRKLREMVRPCSEVFSQPAAKDVCTPTVMSTFLNRVTLNWPVFGAIDFWAQFVFLGVFLIVFLTTLFRTPRLDMSEIDAAADAEDEGLLASTGRRFGATWQDITGRVNQGHGHSHEGYGTGTEGSSALRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCW7</accession>
    <name>G0SCW7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0058630</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696183.1">
        <property type="nucleotide sequence ID" value="XM_006696120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCW7"/>
    <dbReference type="STRING" id="759272.G0SCW7"/>
    <dbReference type="GeneID" id="18259901"/>
    <dbReference type="KEGG" id="cthr:CTHT_0058630"/>
    <dbReference type="eggNOG" id="KOG0010">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024293_0_1_1"/>
    <dbReference type="OMA" id="PGMDMFG"/>
    <dbReference type="OrthoDB" id="267397at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14324">
        <property type="entry name" value="UBA_Dsk2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16106">
        <property type="entry name" value="Ubl_Dsk2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ubiquitin domain-containing protein DSK2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
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    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBA-like_sf"/>
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        <property type="entry name" value="Ubiquilin"/>
    </dbReference>
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        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
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        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
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        <property type="entry name" value="FI07626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBIQUILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="16"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="410"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS19238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="455" mass="46724" checksum="AEB9084D598A9F75" modified="2011-10-19" version="1">MADSAEAGGEAQSQQITFKVKSSNDKTHTITMDESATVLDLKTKLSGPDFEDIPVDRQRLIYSGRIMKDSDTLSVYKIKPNNTIHLVKSARSNQTAAASTPASTSASSSTPTPAVPQNMAAGTSAGDPLAALTGARYAGLANLPSFDLFGADGGMGAPPSDEQIADMLSNPAVAQSMQAALNNPNFVDYMIQMNPMLASMPNAREVLNSPQFRALMTNPEAIRMAARLRRVLQESAGANFPAPGAVDNASSGQPAGSPTSGGNANSANNANDPLRSLFGMPGLFGAPLGSDASNPFAALFGAPPPASNTGGTAAGATSSTSSQPAASVQGGSGSSGSSANTPNQPAGTAPPFNPFAALFGGANQANNQGGASLPNPFGLPLPPIPPETFQQMAQAWGFAPPAVAPQDNRPPEERYAEQLRQLNDMGFFDFERNVAALRRSGGSVQGAIEYLLSNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDC0</accession>
    <name>G0SDC0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative hmp1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0051240</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695466.1">
        <property type="nucleotide sequence ID" value="XM_006695403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDC0"/>
    <dbReference type="STRING" id="759272.G0SDC0"/>
    <dbReference type="GeneID" id="18259162"/>
    <dbReference type="KEGG" id="cthr:CTHT_0051240"/>
    <dbReference type="eggNOG" id="KOG3771">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025518_0_1_1"/>
    <dbReference type="OMA" id="CKIYGMI"/>
    <dbReference type="OrthoDB" id="2159336at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07599">
        <property type="entry name" value="BAR_Rvs167p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000048">
        <property type="entry name" value="BAR adaptor protein RVS167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000189">
        <property type="entry name" value="BAR adaptor protein RVS167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1470.10">
        <property type="entry name" value="YjbJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036629">
        <property type="entry name" value="YjbJ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF1">
        <property type="entry name" value="REDUCED VIABILITY UPON STARVATION PROTEIN 167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69047">
        <property type="entry name" value="Hypothetical protein YjbJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="8">
        <location>
            <begin position="17"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="411"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="280"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="506"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="607"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="307"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="375"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="530"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS18521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="644" mass="71441" checksum="8F61ECF3553B840D" modified="2011-10-19" version="1">MSFRGFQKGLARAPQQIKAKLNIGDNTKDAVYIDAERRFQDLERETKRLHDESKKYFEAINSMLQHQIEFAKAMTEIYKPISGRMSDPETLKVDGNPDGIRACEEYEAVVKDLQETLQPELEMIETRVIRPATELLDVIKVIRKTATKREHKKLDYDRHRNALKKLQEKKDKSSKDEKAMWKVENDLELATQEYNYYNDLLKAELPKLFELEREFIQPLFQSFYYMQLNIFYTLHERMQRVDIGYFDLTLDVEEAFIQKRGDIQERAEALTITRFRTTGRLREPKYQRPGAGAIEGSKPAGLLTAGTSSAQTLSTSPTATSPATATATTSTTTSASSKFPAYNPSTRPSWQQQSSDSVDSPPPPYSSPGTTPGIAKPLSTTASSLAAAAAAKSKPKPPPPPKPKPARLAAPKVETVTALYDFSAQAEGDLSFRAGDVIEVVQRTQNENEWWTGRLNGVVGQFPGDTPSTLKACMDAATGAVQHAIGHMTGDSSKEEHGKEKQRMARSEYEESHAVTRLRGTTSSSTGAIAEDHPDRPEGSWKQTAGTAKQFIGNLVGDENLKQAGREQDMSGRAQETRGQIRDFASGLGDRVIGALGSAAADLTGNKEKQAKFKERHDVGKTRERGAEVGLQKKFEDGKQVTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDS8</accession>
    <name>G0SDS8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L22-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0052850</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="476" last="476">
            <title>High-resolution structures of a thermophilic eukaryotic 80S ribosome reveal atomistic details of translocation.</title>
            <authorList>
                <person name="Kisonaite M."/>
                <person name="Wild K."/>
                <person name="Lapouge K."/>
                <person name="Ruppert T."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="35079002"/>
            <dbReference type="DOI" id="10.1038/s41467-022-27967-9"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.90 ANGSTROMS)</scope>
    </reference>
    <reference evidence="10 11 12" key="3">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e56910" last="e56910">
            <title>Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation during pre-60S biogenesis.</title>
            <authorList>
                <person name="Lau B."/>
                <person name="Huang Z."/>
                <person name="Kellner N."/>
                <person name="Niu S."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
                <person name="Cheng J."/>
            </authorList>
            <dbReference type="PubMed" id="37129998"/>
            <dbReference type="DOI" id="10.15252/embr.202356910"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <reference evidence="14 15 16" key="4">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e57984" last="e57984">
            <title>Structural insights into coordinating 5S RNP rotation with ITS2 pre-RNA processing during ribosome formation.</title>
            <authorList>
                <person name="Thoms M."/>
                <person name="Lau B."/>
                <person name="Cheng J."/>
                <person name="Fromm L."/>
                <person name="Denk T."/>
                <person name="Kellner N."/>
                <person name="Flemming D."/>
                <person name="Fischer P."/>
                <person name="Falquet L."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="37921038"/>
            <dbReference type="DOI" id="10.15252/embr.202357984"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.12 ANGSTROMS)</scope>
    </reference>
    <reference evidence="8 9" key="5">
        <citation type="journal article" date="2023" name="Nat. Struct. Mol. Biol." volume="30" first="670" last="677">
            <title>Structural inventory of cotranslational protein folding by the eukaryotic RAC complex.</title>
            <authorList>
                <person name="Kisonaite M."/>
                <person name="Wild K."/>
                <person name="Lapouge K."/>
                <person name="Gese G.V."/>
                <person name="Kellner N."/>
                <person name="Hurt E."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="37081320"/>
            <dbReference type="DOI" id="10.1038/s41594-023-00973-1"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.20 ANGSTROMS)</scope>
    </reference>
    <reference evidence="13" key="6">
        <citation type="journal article" date="2024" name="Nat. Commun." volume="15" first="716" last="716">
            <title>Methionine aminopeptidase 2 and its autoproteolysis product have different binding sites on the ribosome.</title>
            <authorList>
                <person name="Klein M.A."/>
                <person name="Wild K."/>
                <person name="Kisonaite M."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="38267453"/>
            <dbReference type="DOI" id="10.1038/s41467-024-44862-7"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.10 ANGSTROMS)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695624.1">
        <property type="nucleotide sequence ID" value="XM_006695561.1"/>
    </dbReference>
    <dbReference type="PDB" id="7OLC">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="LU=1-127"/>
    </dbReference>
    <dbReference type="PDB" id="7OLD">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="LU=1-127"/>
    </dbReference>
    <dbReference type="PDB" id="7Z3N">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="LU=1-127"/>
    </dbReference>
    <dbReference type="PDB" id="7Z3O">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.30 A"/>
        <property type="chains" value="LU=1-127"/>
    </dbReference>
    <dbReference type="PDB" id="8I9X">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="LU=1-127"/>
    </dbReference>
    <dbReference type="PDB" id="8I9Y">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="LU=1-127"/>
    </dbReference>
    <dbReference type="PDB" id="8I9Z">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="LU=1-127"/>
    </dbReference>
    <dbReference type="PDB" id="8IA0">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="LU=1-127"/>
    </dbReference>
    <dbReference type="PDB" id="8OO0">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="LU=1-127"/>
    </dbReference>
    <dbReference type="PDB" id="8PV1">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.56 A"/>
        <property type="chains" value="LU=1-127"/>
    </dbReference>
    <dbReference type="PDB" id="8PV2">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.63 A"/>
        <property type="chains" value="LU=1-127"/>
    </dbReference>
    <dbReference type="PDB" id="8PV3">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="LU=1-127"/>
    </dbReference>
    <dbReference type="PDB" id="8PV4">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="LU=1-127"/>
    </dbReference>
    <dbReference type="PDB" id="8PV5">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.86 A"/>
        <property type="chains" value="LU=1-127"/>
    </dbReference>
    <dbReference type="PDB" id="8PV6">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.94 A"/>
        <property type="chains" value="LU=1-127"/>
    </dbReference>
    <dbReference type="PDB" id="8PV7">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.12 A"/>
        <property type="chains" value="LU=1-127"/>
    </dbReference>
    <dbReference type="PDB" id="8PV8">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.91 A"/>
        <property type="chains" value="LU=1-127"/>
    </dbReference>
    <dbReference type="PDB" id="8PVK">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.55 A"/>
        <property type="chains" value="LU=1-127"/>
    </dbReference>
    <dbReference type="PDB" id="8PVL">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.19 A"/>
        <property type="chains" value="LU=1-127"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDS8"/>
    <dbReference type="EMDB" id="EMD-12976"/>
    <dbReference type="EMDB" id="EMD-12977"/>
    <dbReference type="EMDB" id="EMD-14479"/>
    <dbReference type="EMDB" id="EMD-14480"/>
    <dbReference type="EMDB" id="EMD-17004"/>
    <dbReference type="EMDB" id="EMD-17950"/>
    <dbReference type="EMDB" id="EMD-17951"/>
    <dbReference type="EMDB" id="EMD-17952"/>
    <dbReference type="EMDB" id="EMD-17953"/>
    <dbReference type="EMDB" id="EMD-17954"/>
    <dbReference type="EMDB" id="EMD-17955"/>
    <dbReference type="EMDB" id="EMD-17956"/>
    <dbReference type="EMDB" id="EMD-17957"/>
    <dbReference type="EMDB" id="EMD-17969"/>
    <dbReference type="EMDB" id="EMD-17970"/>
    <dbReference type="EMDB" id="EMD-35287"/>
    <dbReference type="EMDB" id="EMD-35288"/>
    <dbReference type="EMDB" id="EMD-35289"/>
    <dbReference type="EMDB" id="EMD-35290"/>
    <dbReference type="SMR" id="G0SDS8"/>
    <dbReference type="STRING" id="759272.G0SDS8"/>
    <dbReference type="GeneID" id="18259323"/>
    <dbReference type="KEGG" id="cthr:CTHT_0052850"/>
    <dbReference type="eggNOG" id="KOG3434">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105624_0_0_1"/>
    <dbReference type="OMA" id="YQLRFYN"/>
    <dbReference type="OrthoDB" id="10259820at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.210:FF:000001">
        <property type="entry name" value="60S ribosomal protein L22 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002671">
        <property type="entry name" value="Ribosomal_eL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038526">
        <property type="entry name" value="Ribosomal_eL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064:SF31">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL22A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01776">
        <property type="entry name" value="Ribosomal_L22e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6 7 8" id="KW-0002">3D-structure</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS18679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="7OLC"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="7OLD"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="7Z3N"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="7Z3O"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="8I9X"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="8I9Y"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="8I9Z"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="8OO0"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="8PV1"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="8PV2"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="8PV3"/>
        </source>
    </evidence>
    <sequence length="127" mass="14278" checksum="C2D70815E9071B6B" modified="2011-10-19" version="1">MAPVAKKSGAKGKGPKVTKKFIINASQPASDKIFDVSAFEKFLNERIKVDGRVGNLGDVIKISQIGDGKVEIIAHNDLSGRYLKYLTKKFLKKMQLRDWLRVVATSKGVYELKFYNIVNDEAEEEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDY4</accession>
    <name>G0SDY4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0053440</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695680.1">
        <property type="nucleotide sequence ID" value="XM_006695617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDY4"/>
    <dbReference type="STRING" id="759272.G0SDY4"/>
    <dbReference type="GeneID" id="18259382"/>
    <dbReference type="KEGG" id="cthr:CTHT_0053440"/>
    <dbReference type="eggNOG" id="KOG1430">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045030_1_0_1"/>
    <dbReference type="OMA" id="PQTAWLN"/>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF11">
        <property type="entry name" value="LD23561P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="376" mass="42553" checksum="57DE8E2166F1179F" modified="2011-10-19" version="1">MAEKPSVLIIGGLGYIGRWLAYYIHKNDLASEVRIVDKVLPQLAWLPPEFEEACSGSKFVQADASREQSLPRIFDRPDGKTWDYVFNCGGETRYSQEDEVYRLRSLGLSLNIGREAAKRGVKCFVELSTGMVYKPDSQPSKEGDKLKPWSKIAVFKLQAEEELSKIEGLNLVIVRLPHVYGPYASQWVATALCMARVYKALESEMKWLWTKDLRTNTAHIHDVVRALWAVADWYDAKGKANWDESSMGKIPIFNVVDHGCTTQGTLADIIGEIFGIETGFQGQLISTFAKLNLDSVVDDVNDELLGPWSDLLEEAGITKPGPLTPFMEKELLKDTDLSMDGSRLEQVVGFEYERPQMTKELIEEVIESYKKMNWWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDZ2</accession>
    <name>G0SDZ2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phenol 2-monooxygenase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0053520</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695688.1">
        <property type="nucleotide sequence ID" value="XM_006695625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDZ2"/>
    <dbReference type="STRING" id="759272.G0SDZ2"/>
    <dbReference type="GeneID" id="18259390"/>
    <dbReference type="KEGG" id="cthr:CTHT_0053520"/>
    <dbReference type="eggNOG" id="KOG3855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_9_3_1"/>
    <dbReference type="OMA" id="IYDIAFW"/>
    <dbReference type="OrthoDB" id="5325318at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF4">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="111"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="7">
        <location>
            <begin position="458"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="46"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS18743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="683" mass="76990" checksum="48FA7E49EEE7B91C" modified="2011-10-19" version="1">MEAHETKTPRAKGRELGDDKAPTLVLAQPDTLKNEVNNQLSSTAAAAAPCSLAPQPQAERTAAPTMSPAAVVEKPGEDQPNNEDRMDTTESIDRLTLLRSMPEPPLECQVADGLQPKTIETFRQMRLADPLLQRGVRVYDICFWRSTPDEPLHRLGREVHYPPVIDVLDPYILLVHQGMVESLFIEDLRKRGYEVRRNTAFESYSVCDSKGGPLQVNCRTNVTQDRKTILTQYLVGCDGAHSKVRRSIPDAKPVGLSQPSVWGVLDGELITDFPDIWSKTLVYSQEHGSILIIPRERNMTRFYIELKSGPKGDRSQLGQEFVMQRAKEIMAPFRVDWKYVEWFGRYQIGQRVASRFCDNHLRAFLAGDASHTHSPKAAQGMNTSMHDAWNLGWKLNLAVRGLAKPDLLKSYEEERRKIALDLVNFDYEHANQIAGGDAVALAENFKTNVRFISGIGADYPENCLNMMESQSWVMGEAKPGCLLPPAKVTRYIDSNPVDIQLDIPMLGQFRIYLLMWDVHQSRIWLETFCQAIASKESYISKLSAAANLSYAQQPRSPAPEDIYLRPERYTAVSHLFTFALITTMPKSEIEIADLPPLFQDSRWTFYLDDIPEQDTRGSLCTNKWLGSLGPGEVAIVNVRPDGYVGSIGRWDSSVDESGEDAARWLDRYYERFLQLPPIVAALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G0SE62</accession>
    <name>G0SE62_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Spermidine synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0062570</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696570.1">
        <property type="nucleotide sequence ID" value="XM_006696507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SE62"/>
    <dbReference type="STRING" id="759272.G0SE62"/>
    <dbReference type="GeneID" id="18260295"/>
    <dbReference type="KEGG" id="cthr:CTHT_0062570"/>
    <dbReference type="eggNOG" id="KOG1562">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048199_1_0_1"/>
    <dbReference type="OMA" id="FLYHEMM"/>
    <dbReference type="OrthoDB" id="38125at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.140.10:FF:000001">
        <property type="entry name" value="SPE3p Spermidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000013">
        <property type="entry name" value="Spermidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.140.10">
        <property type="entry name" value="Spermidine synthase, tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030373">
        <property type="entry name" value="PABS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030668">
        <property type="entry name" value="Spermi_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035246">
        <property type="entry name" value="Spermidine_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037163">
        <property type="entry name" value="Spermidine_synt_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002010">
        <property type="entry name" value="PRK00811.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00417">
        <property type="entry name" value="speE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558:SF11">
        <property type="entry name" value="SPERMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558">
        <property type="entry name" value="SPERMIDINE/SPERMINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17284">
        <property type="entry name" value="Spermine_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000502">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01330">
        <property type="entry name" value="PABS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="5">
        <location>
            <begin position="14"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS18239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="296" mass="33746" checksum="5A0CC981E865F1E7" modified="2011-10-19" version="1">MSSEGEITHPTIKDGWFREISDMWAGQAMTLRVKKVLHHEKSKYQDVLIFESTDHGRVLVLDNVIQCTERDEFSYQEMITHLAMNSHPEPKKVLVIGGGDGGVLREVVKHECVEEAILCDIDEAVIRLSKQYLPNMAVGFNHPKVKVHVGDGFKFLAEYKNTFDVIITDSSDPEGPAESLFQKPYFQLLYEALRDGGVITTQGSENQWLHLPLITKLKKDCSEIFPVAEYAYTTIPTYPSGQIGFMVCCKDPNRDVKVPLRTWSKEEERRLCKYYNSEIHKAAFVLPTFAQMALEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEJ6</accession>
    <name>G0SEJ6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative covalently-linked cell wall protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0063980</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PIR protein family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696704.1">
        <property type="nucleotide sequence ID" value="XM_006696641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEJ6"/>
    <dbReference type="GeneID" id="18260436"/>
    <dbReference type="KEGG" id="cthr:CTHT_0063980"/>
    <dbReference type="eggNOG" id="ENOG502RKR1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049782_0_0_1"/>
    <dbReference type="OMA" id="IGDGQPQ"/>
    <dbReference type="OrthoDB" id="5415592at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054508">
        <property type="entry name" value="PIR1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051153">
        <property type="entry name" value="Yeast_CWMannoprotein_PIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000420">
        <property type="entry name" value="Yeast_PIR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47254">
        <property type="entry name" value="CELL WALL MANNOPROTEIN CIS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47254:SF1">
        <property type="entry name" value="CELL WALL MANNOPROTEIN CIS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00399">
        <property type="entry name" value="PIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22799">
        <property type="entry name" value="PIR1-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50256">
        <property type="entry name" value="PIR_REPEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409171" evidence="9">
        <location>
            <begin position="19"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Cell wall mannoprotein PIR1-like C-terminal" evidence="10">
        <location>
            <begin position="80"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS18373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="313" mass="32260" checksum="280B969A6765C2B8" modified="2011-10-19" version="1">MKIQAFTLAACAVASVAAQGVTEPISPPGSVPVGCIPSIDGKFEITVVQITDAESRSAALMKRATCSGDGVLVSTLRDTVIKDAFNRTGYIASNFQFQFDNPPQAGAIYTAGFSFCPENSTLALGATTTFYQCRSGDFYNLYDRYWAPQCEPVDIIVIPCNDATENSGAPTQTVIGSATILTTIVIPLSDGQPQVITTDKVIPICQIDDGQIQGHTAPCTGPVATITATPLITQISDGQIQVTGIPATVTVPLVTQISDGQIQAPPATTTPVGPFQPTEAPPANENGAAPLVGGILVGALVAAIIGVALVLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEZ3</accession>
    <name>G0SEZ3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription initiation factor TFIID subunit 7-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0060220</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696340.1">
        <property type="nucleotide sequence ID" value="XM_006696277.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0SEZ3"/>
    <dbReference type="GeneID" id="18260060"/>
    <dbReference type="KEGG" id="cthr:CTHT_0060220"/>
    <dbReference type="eggNOG" id="KOG4011">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016434_1_1_1"/>
    <dbReference type="OMA" id="KWEKMQN"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08047">
        <property type="entry name" value="TAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037817">
        <property type="entry name" value="TAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006751">
        <property type="entry name" value="TAFII55_prot_cons_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228:SF0">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID 55 KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04658">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01370">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII55 protein conserved region" evidence="7">
        <location>
            <begin position="209"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="382"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="479"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="70"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="490"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS18009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="602" mass="65087" checksum="F5A6B6D20EB1ED32" modified="2011-10-19" version="1">MESPQPPPQPKRLPSLKITASGQIVTSTNSSSASGLSNGTSSAPPQSAPSQTPQSTAGSGFPKIKLVAKSSTVQPSQPSTPADSRPSDAMLSAAASSPSSGPPKIVTQAGRVSIPTAKKRAREENDDSDEDLPLAAKNHHHNYQSNASKNDSPHIKKTKITIKPPTTPGGGGIVRQPTLKVKPVGRIPTRPPGEGYDSEAEDREVDPVIEEQFLLRLLPGEHCEYVRKCIQERKIGLPKHQGGADIQLRWLDDEGRRACLTILGQHFAGVLLDLPTITEGMKTWDKKNMVKSSDICQMLLVFAKVNSEEEAKSIELPSPVEPGYRWPHGITPPMHDARNRRFRKRLSKLEIKNKEAEVERLLNADRDAVNVKTEWIDAKREVAEVEEDEEEYDEDAEGEMDEFFGRGRGGGGGEXXXXXXXRGEEEAESEVDDAALEAEFLDAQETPIEGAGVTVSASTIVAASAPSAGAAGAAAVDGVTPVTANGTPGAEEEAAGEEELDEGEEGGDEEEEEEEEEDDEEDEEDEDEGGEGGADDEDDEDHDKKASVRNEIAQLKRQLKQYEEQLASVTGPIMKKRLEGNIKNIMSEIQLKKSILGEADED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G0SF50</accession>
    <name>G0SF50_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aspartyl-tRNA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0060810</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696397.1">
        <property type="nucleotide sequence ID" value="XM_006696334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SF50"/>
    <dbReference type="STRING" id="759272.G0SF50"/>
    <dbReference type="GeneID" id="18260119"/>
    <dbReference type="KEGG" id="cthr:CTHT_0060810"/>
    <dbReference type="eggNOG" id="KOG2411">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014330_2_1_1"/>
    <dbReference type="OMA" id="LCGWVDR"/>
    <dbReference type="OrthoDB" id="439710at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="entry name" value="GAD-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00459">
        <property type="entry name" value="aspS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="7">
        <location>
            <begin position="166"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS18066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="660" mass="72761" checksum="C4C4CC8B919AB34D" modified="2011-10-19" version="1">MLIDQFPRASKAADFVEGQQVTVHGFLSGKRVKGSALAFADIQIDGGPKIQIVSTFKKQNSPAHAAHTALRSIPLHSPVSVTGTVAKLYGTPSPAESSSTAPGSFPDGVSRIDIDLESIQPLNVFPKDIIVSKDVQFPPTARHLQIRFSDPLRSRLLARPKMALQLRQSLDRLGFTEVETPVLFKSTPEGAREFLVPTRRAGFAYALPQSPQQYKQMLMASGIRGYYQFARCFRDEDLRADRQPEFTQLDLEISFATGEDVIRTVESIVSDLTQSLTTNFTHVKKGDEVYLAPKRVQEPAEAEGLDIQPCYTKPPFPRITYEEAMTRFGIDKPDARIPFEIHRLDHILPKSFVSMITDLENPVVEGFRFRPQQEDLPESGPSAAMFDEIMKNLPPALEKNPDGAPVALVIDSRKPLRGLSPLGFEGVAALESGEPGLEEFADLEDGDVLVFQARENKPFQGGSTALGTFRTLVYQQAVSKGLLPRDLSFRFLWVVNFPMFTPDNDTDPGQGGSAGFSATHHPFTAPLTDADVELLATDPLKARADHYDLVVNGVELGGGSRRIHVAKMQEYIMREILKMTDQGVAQFSHLLEALRAGCPPHAGFALGFDRLVAVLTYTDSVRDVIAFPKSMKGEDLTVKSPSKITKEQLETYHLAFAGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFD1</accession>
    <name>G0SFD1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="11 13">3.2.1.106</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Glucosidase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CTHT_0061620</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="23 24 25" key="2">
        <citation type="journal article" date="2022" name="Biochemistry" volume="61" first="822" last="832">
            <title>Identification of Endoplasmic Reticulum alpha-Glucosidase I from a Thermophilic Fungus as a Platform for Structure-Guided Antiviral Drug Design.</title>
            <authorList>
                <person name="Karade S.S."/>
                <person name="Kolesnikov A."/>
                <person name="Treston A.M."/>
                <person name="Mariuzza R.A."/>
            </authorList>
            <dbReference type="PubMed" id="35476408"/>
            <dbReference type="DOI" id="10.1021/acs.biochem.2c00092"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.19 ANGSTROMS) OF 30-809</scope>
        <scope>GLYCOSYLATION AT ASN-45</scope>
        <scope>DISULFIDE BONDS</scope>
    </reference>
    <reference evidence="20 21 22" key="3">
        <citation type="journal article" date="2023" name="J. Med. Chem." volume="66" first="2744" last="2760">
            <title>Structure-Based Design of Potent Iminosugar Inhibitors of Endoplasmic Reticulum alpha-Glucosidase I with Anti-SARS-CoV-2 Activity.</title>
            <authorList>
                <person name="Karade S.S."/>
                <person name="Franco E.J."/>
                <person name="Rojas A.C."/>
                <person name="Hanrahan K.C."/>
                <person name="Kolesnikov A."/>
                <person name="Yu W."/>
                <person name="MacKerell A.D."/>
                <person name="Hill D.C."/>
                <person name="Weber D.J."/>
                <person name="Brown A.N."/>
                <person name="Treston A.M."/>
                <person name="Mariuzza R.A."/>
            </authorList>
            <dbReference type="PubMed" id="36762932"/>
            <dbReference type="DOI" id="10.1021/acs.jmedchem.2c01750"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.91 ANGSTROMS) OF 30-809</scope>
        <scope>GLYCOSYLATION AT ASN-45</scope>
        <scope>DISULFIDE BONDS</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="14">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="11 13"/>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_006696415.1"/>
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        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.91 A"/>
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        <property type="resolution" value="2.19 A"/>
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        <property type="resolution" value="2.32 A"/>
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        <property type="resolution" value="2.33 A"/>
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        <property type="chains" value="A/B=30-809"/>
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        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="A/B=30-809"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFD1"/>
    <dbReference type="SMR" id="G0SFD1"/>
    <dbReference type="STRING" id="759272.G0SFD1"/>
    <dbReference type="GeneID" id="18260200"/>
    <dbReference type="KEGG" id="cthr:CTHT_0061620"/>
    <dbReference type="eggNOG" id="KOG2161">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007380_1_0_1"/>
    <dbReference type="OMA" id="FNWYNTT"/>
    <dbReference type="OrthoDB" id="410058at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000027">
        <property type="entry name" value="Probable mannosyl-oligosaccharide glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.110:FF:000003">
        <property type="entry name" value="Probable mannosyl-oligosaccharide glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.110">
        <property type="entry name" value="Glycosyl hydrolase family 63, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031631">
        <property type="entry name" value="Glyco_hydro_63N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038518">
        <property type="entry name" value="Glyco_hydro_63N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF11">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16923">
        <property type="entry name" value="Glyco_hydro_63N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="20 21 22" id="KW-0002">3D-structure</keyword>
    <keyword evidence="5 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409186" description="Mannosyl-oligosaccharide glucosidase" evidence="15">
        <location>
            <begin position="28"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 N-terminal" evidence="17">
        <location>
            <begin position="47"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="16">
        <location>
            <begin position="313"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="22 23 24">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20 21 22">
        <location>
            <begin position="654"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU369107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGS18147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PDB" id="7R6J"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="21">
        <source>
            <dbReference type="PDB" id="7RD2"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="22">
        <source>
            <dbReference type="PDB" id="7REV"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="23">
        <source>
            <dbReference type="PDB" id="7T66"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="24">
        <source>
            <dbReference type="PDB" id="7T68"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="25">
        <source>
            <dbReference type="PDB" id="7T6W"/>
        </source>
    </evidence>
    <sequence length="831" mass="94360" checksum="34610045ACA56654" modified="2011-10-19" version="1">MAFKRQLGWLLAVACYNAIFASSAVAAADVEGESILHSEIGRLNNQSLLWGPYRPNIYFGTRPRIGKSLMTGLMWGKIESYTDFQHTVRYTCEQNEGMKGYGWDEYDPRRGGIQSIHDIQNGLDITTSFVKIPGGAHGGSWAARIKGTLNDDAPKDQKTIVVFYVSQEGENSELEAVPSENEFGYEGDVILKGRSEALGNYKLVVTKGKGVIPQSDHDLSRLRGPGQTVVQSLTYPDEVLWQAKPILFQQLKAGIDWLVENKYDVADPPPPWQVYLLANKPGSGNVHIVQKVFEGDFEFDILFSSESAGKEVTSKDLEREVKQATEVFGERFARVFDLKAPFQGDNYKKFGKSMFSNLIGGIGYFYGHSLVDRSYAPEYDEENEGFWEDAAEARARHQEALEGPYELFTSIPSRPFFPRGFLWDEGFHLLPIADWDIDLALEIIKSWYNLMDEDGWIAREQILGAEARSKVPKEFQTQYPHYANPPTLFLVLDNFVERLRKNNASQPVVKDNLSLDETLSTASVDNPEVGLEYLRRLYPLLRRQFDWFRKTQAGDIKSYDREAYSTKEAYRWRGRTVSHCLTSGLDDYPRPQPPHPGELHVDLMSWVGVMVKSLISIGSLLGATEDVEFYTKVLDAIEHNLDDLHWSEKEGCYCDATIDEFEEHKLVCHKGYISLFPFLTGLLKPDSPKLGKLLALIGDESELWSPYGLRSLSKKDEFYGTAENYWRSPVWININYLAIVQLYNIATQDGPYKETARDLYTRLRKNIVETVYRNWEETGFAWEQYNPETGKGQRTQHFTGWTSLVVKIMAMEDISGEGAGASSGGHVRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFG4</accession>
    <name>G0SFG4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative actin cross-linking protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0070720</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-actinin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697347.1">
        <property type="nucleotide sequence ID" value="XM_006697284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFG4"/>
    <dbReference type="STRING" id="759272.G0SFG4"/>
    <dbReference type="GeneID" id="18261110"/>
    <dbReference type="KEGG" id="cthr:CTHT_0070720"/>
    <dbReference type="eggNOG" id="KOG0035">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005217_0_2_1"/>
    <dbReference type="OMA" id="QQRWITV"/>
    <dbReference type="OrthoDB" id="10017054at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21215">
        <property type="entry name" value="CH_SpAIN1-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21291">
        <property type="entry name" value="CH_SpAIN1-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000138">
        <property type="entry name" value="Alpha-actinin, sarcomeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000097">
        <property type="entry name" value="Alpha-actinin, sarcomeric (F-actin cross linking protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000279">
        <property type="entry name" value="Calponin domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000223">
        <property type="entry name" value="Related to alpha-actinin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000030">
        <property type="entry name" value="Related to alpha-actinin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000077">
        <property type="entry name" value="Related to alpha-actinin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014837">
        <property type="entry name" value="EF-hand_Ca_insen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08726">
        <property type="entry name" value="EFhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="153"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="267"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="627"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="773"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS17729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="807" mass="92029" checksum="F5014E3DFCD50A46" modified="2011-10-19" version="1">MAIDTVQHGWSGGGHTGQALEMRARIPFKTPLDNVQLPSPLCEVNKTTFASTRVRYLTECQPPSLSLSDACRLSRSSSTRLTRAPSASRPPRSFRTRSLSRSRWRQQLDQCLTDARVHIYTDIPAPALLKQSKPPKDTETNTMSYHEQQHWITVQQKTFTKWVNTKLEVRGKEVKDLVRDLCDGVLLIHLLECLSGESLGRYAAKPKLRVQCFENANLALNFIKSRGIQMTNIGAEDVVDGNRKIILGLIWTLILRFTISDINEEGMTAKEGLLLWCQRKTACYDEVDVRDFSTSWNDGLAFCALLDIHRPDLIDYDALDKSDHRGNMQLAFDLAHKEIGIPKLLDVEDVCDVAKPDERSLMTYIAYWFHAFSKMEQVENAGRRVEKFVNNMRGAWDMQHAYERRMAALLKAIREQIQAWREAKFEGTYADAKAQLFEFGAYKKGKKREWVAEKSELATLLGNIKTKLGTYRLKPYEPPAELRLEVLDREWSNLTKAEMARGQLINETIRDIKNALRKSFADKANDFALALNTIQLAISGLEGDIEDQLHHVRKLAENIPPLDAYLETIAAVDAKCQEANIEENDFTTYTYDELCYELSLVKSSVQKKLSFLENQMVARNMTNLTPIQLEEFESVFRHFDRDDTNTLSEIEFSAALASLGLVFTEEETHDYFIQTSNGKDRVTFEQFIRFMVDVTEDQNTAEQVFQSFREVADGKPYVTEMDLRHSLVPDDVIEKLVEIMPPHKGPDMKDDRGMPQYDYIAFMESMMGGEVDLSGYRDDSKRNSVASGRVSPTKRLSTGSAKLNGLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFV1</accession>
    <name>G0SFV1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0072230</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697484.1">
        <property type="nucleotide sequence ID" value="XM_006697421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFV1"/>
    <dbReference type="GeneID" id="18261261"/>
    <dbReference type="KEGG" id="cthr:CTHT_0072230"/>
    <dbReference type="eggNOG" id="ENOG502QSKG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_0_0_1"/>
    <dbReference type="OMA" id="NTVEGWT"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="35094" checksum="4CE56772305CC7F5" modified="2011-10-19" version="1">MTQKSNDPGILPDSHWTNLDPVEIEEGPDSKEDAESILTSTASITSSLLRFRSLHGRTFHSELGNAQAWEPNDRKHIESLDLLDFGDLHPDVEVIGTDITPIQPTWVPPNVSFQIDDATREWTFSENTFDFIHIRFLLGCVIDWDALYQQAFRCLKPGGWIEHQEVSAHWYSEKGIDEDSPLGQYPKIYREAGNRMGRTFMLYEDEIQKKGMEAAGFTDIHVRDIKVPFGDWPEDEHQREIGLITKAGAMADLDGWIIYVLNEVLGWQPEASQVFLAHVRRQLREPGLNLYWMRRIVYARKPETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0SG25</accession>
    <name>G0SG25_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Siroheme synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0064790</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696782.1">
        <property type="nucleotide sequence ID" value="XM_006696719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SG25"/>
    <dbReference type="GeneID" id="18260517"/>
    <dbReference type="KEGG" id="cthr:CTHT_0064790"/>
    <dbReference type="eggNOG" id="ENOG502S6KJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034400_0_0_1"/>
    <dbReference type="OMA" id="SRAAWMF"/>
    <dbReference type="OrthoDB" id="8864979at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025204">
        <property type="entry name" value="CENP-L"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13092">
        <property type="entry name" value="CENP-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="438" mass="48154" checksum="13593DA34B5C2386" modified="2011-10-19" version="1">MPPKRRTSAPKSPPAEEPTAARNSESELFVGQGNNEHDESEETTSYVLFYNTTFSAHRVSPLYLGNEPLTEGRLRILSQRLRDRLVGDVVRGVEVRLISDGEGSVLARAGSLEKVEMEWVSVASVLALSRSNLEALSKGGNVENLREKKALHITLRYELAFCTALLLPSFGRGAEKRPEAEKTKFTIGVNSGGDEMDWEPTDGQTQFLDLPLMLMRMPPPLKAVVADFLATTFDCRVSPMRLGTRSLIGSWESWIQSAGVPTEGPLAKDMVLTLGFHVPTPESDSKEDSEDHTLGLKTIDIIIPGTELSKFVSAGQHLSSQPQPPLTDWGWESDLKKRRELAGRLYEEGWDWRADKKQPFTEALGAYMSEHLAVNLFHPGVRVVKIACGGFSMSESRLKVFAPVDSQDGESGVAKHKSAVLELLGALVEKSRVLMLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGF5</accession>
    <name>G0SGF5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0066140</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696912.1">
        <property type="nucleotide sequence ID" value="XM_006696849.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0SGF5"/>
    <dbReference type="GeneID" id="18260652"/>
    <dbReference type="KEGG" id="cthr:CTHT_0066140"/>
    <dbReference type="eggNOG" id="ENOG502S2X2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001132_0_0_1"/>
    <dbReference type="OMA" id="CWQLSQP"/>
    <dbReference type="OrthoDB" id="5403573at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042791">
        <property type="term" value="P:5S class rRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046488">
        <property type="entry name" value="Sfc3/Tfc3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044210">
        <property type="entry name" value="Tfc3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007309">
        <property type="entry name" value="TFIIIC_Bblock-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04182">
        <property type="entry name" value="B-block_TFIIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20222">
        <property type="entry name" value="DUF6581"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="B-block binding subunit of TFIIIC" evidence="7">
        <location>
            <begin position="166"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor tau subunit sfc3/Tfc3 C-terminal" evidence="8">
        <location>
            <begin position="1787"/>
            <end position="2211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="486"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="539"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="797"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="883"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1106"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1348"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1411"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1717"/>
            <end position="1752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="612"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="813"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1371"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1426"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1732"/>
            <end position="1746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS17294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="2264" mass="252721" checksum="5A4AEC9B65D43AA1" modified="2011-10-19" version="1">MSGLGLEVLLEGLIPEIAYSGEKGVSITELLKIVRKYHLSLNGQDVESLASIDDADLEKSLTEAEMASARWAWDWLRSRPQILINGDRRYNKLELDEVLALPEADKVGPALAGASSMSAPEKGQKGKKGSKSKDLTLTVRPRIHPSEELVWQTLTRHGVDYKRVPALEWACLQGIASARAEGILQSDLRKLVNQDKRSLPKRTDSLARKGYIAKRTVVVQKMKTSRLWLIDFAPPLVEADAAGLDLSPETLSKDLEPVQWHSRWTGNNIDMDALGRTAVGVVKAFNVMRYSDLRSKMGVVGKRWQMKTLAKTCQRLVDMGMLKYTAASFPGSRKVFKDCLKFIREPTSEEWEKFLATGKKTSQYSDPTRHREPKPNALALYKKADDNDEQKGGDDKSKLKRIFSGWTPEKPLPQTVFEVIKSAGPEGASNPQVSVATVGYQHRRYLSSYLTKVAETQQPPHLKKFQVVSKLVRHGKTSAYMFSAAVNNPEHQPEKEATQTESSNPADRYGFGAVRPKLFAPEEEATLSNFSRLARKSRPYAKRKTLPPTPKVGDVVAEPAPETARQADVEMQELPASQKSTEEKLEEQLAETPTSEPAPLEAMEVEPTAVETAEKPVDTQKHQAREPEAGQEPGEEQQEPSQDAAKEEVQQQETSDEALPSGFTPINKVPPKKREEIALNVQYNDKWGRLRLSFAEKNLVWLRSGRGLKKPLIIRIDDTLLDSEIQDVPDSNDRSLVLKVQVDKDEAPWTCVFILDNEPDSQQNAMEIQEVIAKIKAGEEVDPGADEEAALEETDFAQDATAEATPAESGSRPRGRPAGRGRGGARSKGKKPRRPPLPPGVKPFVCPTCGGAWKNDIGLKYHLEKAQVPCNPNFDPNAVIRRRRRQSPVPPPPESVQSDAGEETADVTTENATRPRRAKAAGRERKEEKKKHRPRPNVRAAMRSTRDVVNGFRGVGAADPEPEEEMEIDWEAEKARVVSRYRAFQEAKPVEQLEPQFGVPAAAEQGFLVAKHSTLSALPACPSTTSSFSESMTYPRSIAAAQNGTTKLPEQAQAHIVSASLPTAPSTPPDTLDHSATAQGLAPVEIARAPSDNTQQSPIDRGIAASVSSVSQSYPEPPSYSTAEETAQFTAAQTEAATNKPEETSRIKPFIPSSYDRLATDAKKRTAQAFDIINYLLDNNCGVFPGEKALYYAVTKVFLQEFRGQVPPSWKNFLSAVRAIESRKLATVHTHMLRTERGKLQTCTLLIRSGVDPNGVVPAIMKQKMREAYPSIFIPPAFSPTQEELALLQELDKKPMPQPIETKPNANGQKFRSRRKYDEVEVFNAPYYTQNAETMEVKRDPLWFREDSEFPYAGRGPGRPRKRPVEEGAETSPQKKVNVSAQESFGIPSAPASQSASCEIPVDPTILTLSAGSTSSVQGERETPAQNGVQQGQNGSFSGNGTGPTSLVDAIRVYSLLPARMGGRRKTNSTPETLTKVPREVGRIRNPGLASLPGDFWTSIGSARAWDIPVVKFLEPNTGLFDGAETDDEDEAVEDLDVTMENADATPEGAKKPKEFTFVEPSILHGYQGAWPSLEADFFEQHDASFTIECWMPDRQQLLAENVPTSAAEMAEKQKAARIRPQDWVDRKYAKFCSLVNQVAAWEQSPEGEAILSGLAIVPGTTFINVSPHPSRYNMRPVDLKWSDDTQFDLETVPYDDLEEDDYLDVNYVDFPPGKGTGRLLGDVPHKRRKIQQQQHAPKESTSTQPRRAMGRPPKLKLQAIKTMRELTAYPRTPDDFLRHPGEEEEDLNWASENVRLAAFIVVTTLLGGVDRVVDWGLMLRLMPDQTISQLRHYWCSLKKDRMSTIVSLTEKFRVAFLRAYENGELPPLDYNNVLAYDWKGLIKWTTQLDGIERRELPASREELDKHFRVAKFEHGNREWREAFFHPQRSIFNKFQDATSEALALPVDDDVRDCDRGRYTGLSTDMIVAMAWTRSLCVTPVEAYSAEMVLHRRNSLFPQYSKTEITELIMKGVDALQRDGVISKSSSKWSNGRRWRFNTRVLDTLEKHAQQEKFVKAAQFKRELDAAFRAGETKRVTYITNDGMIMALLNMQAHGRVRIETTGQPKVPMGHEPGNYETRKYTKKYLHFRLDVVPTETYLYDSPTNPDEPDDLAALRARIRATPPPTQGPNGTIPVWCDVFNKVDAERWLKYLSAVLITLASRGSMGAQELVKTLKPVIMLFEAEMILEWCQRLGVVGSQMDGLAAGVREWWWVVVEAQREGLMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGQ8</accession>
    <name>G0SGQ8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0067220</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697015.1">
        <property type="nucleotide sequence ID" value="XM_006696952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGQ8"/>
    <dbReference type="STRING" id="759272.G0SGQ8"/>
    <dbReference type="GeneID" id="18260760"/>
    <dbReference type="KEGG" id="cthr:CTHT_0067220"/>
    <dbReference type="eggNOG" id="KOG2130">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016785_1_2_1"/>
    <dbReference type="OMA" id="WPAYKNW"/>
    <dbReference type="OrthoDB" id="424465at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050910">
        <property type="entry name" value="JMJD6_ArgDemeth/LysHydrox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480">
        <property type="entry name" value="ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480:SF21">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="47"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="3">
        <location>
            <begin position="202"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS17397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="440" mass="50047" checksum="7B60D04188F79A9A" modified="2011-10-19" version="1">MTVLPYCYPINVVDEANGTPTIPPHPLGIKPLGNKYFWDGQDARKCLGLLQVLPDEVIMQMLEFLDPKTLRLLGYTCRFLFACCMSDDLWKTVFLDKVPLELFTKNIPAANQIDRLEDMSYEEFAANWSKKPFILTKNITAWPVTSQWTLDTLLQQYPDVVFRAEAVDWTFKTYYDYLKNTNDESPLYLFDKKFAEKMGLTIGKDLPGAAYWKPECFGPDLFELLGAERPAHRWVIIGPARSGSTFHKDPNATSAWNAVIQGAKYWVMFPPSAQVPGVIASQDGSEVTSPLSIAEWLLVFHREARRTPGCREGICRAGEILHVPSGWWHLVVNLEDGIALTQNFVPEAHLSSVLSFLRDKPEQISGFRRDIENPYELFVERLRQERPELLEEALRQLGGKKRRWESIVNGDDGEGEGQPQKSGFSFGFGFGDDELEEEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>G0SH25</accession>
    <name>G0SH25_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0068440</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697132.1">
        <property type="nucleotide sequence ID" value="XM_006697069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SH25"/>
    <dbReference type="GeneID" id="18260882"/>
    <dbReference type="KEGG" id="cthr:CTHT_0068440"/>
    <dbReference type="HOGENOM" id="CLU_2497696_0_0_1"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS17514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="86" mass="9451" checksum="E60F3CBB1F14C0BC" modified="2011-10-19" version="1">MPDVVAKVALIQPYKHSPATNVWNRSAPPAPLVLVHDGGGTTFCYHFLGYLGRPVYGIDNPHYDSGKAWEGGIPEMAREYLKPSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHJ3</accession>
    <name>G0SHJ3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative transcriptional repressor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0070220</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697300.1">
        <property type="nucleotide sequence ID" value="XM_006697237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHJ3"/>
    <dbReference type="STRING" id="759272.G0SHJ3"/>
    <dbReference type="GeneID" id="18261060"/>
    <dbReference type="KEGG" id="cthr:CTHT_0070220"/>
    <dbReference type="eggNOG" id="KOG0266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_23_1"/>
    <dbReference type="OMA" id="LTPDANW"/>
    <dbReference type="OrthoDB" id="17410at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000111">
        <property type="entry name" value="Transcriptional repressor rco-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013890">
        <property type="entry name" value="Tscrpt_rep_Tup1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08581">
        <property type="entry name" value="Tup_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Transcriptional repressor Tup1 N-terminal" evidence="8">
        <location>
            <begin position="23"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="363"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="398"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="446"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="484"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="538"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="580"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="89"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="254"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS17682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="624" mass="68237" checksum="59C41BBBCE2DD06F" modified="2011-10-19" version="1">MSMYPAHRGMGAVPPANGGVAARLNELLDQIRAEFDQHLRQTEGFEHQIQAQVQEMQMIRDKVYQMEQAQIAMKQKYEEEIAMLRRQLESRGGPPGPMNPPQHVGPPQPPPPQIGNPGNNGVIGAILSGQVGQGGLAPPPHPEQQQQQPPHMPPAPPGMQGPPPPPPPPSQQPQFQGQYPPGPQPGGFPSQPPQSTASPGPGNKRAIGRPPAGPATPQINTPVPYNGPGQSPQVHTHPTPDHSRALVQQHPPQQHGPPPPPPPPPPASNNLSELDPDRLPNHIKKVRDDWWVIFNQAVPRVLDVELVHTLQHESVVCCVRFSHDGKYVATGCNRSAQIYDVATGEKVCVLQDDSIENNGDLYIRSVCFSPDGKYLATGAEDKLIRVWDIQTRTIRNTFEGHDQDIYSLDFARDGRTIASGSGDRTVRLWDIETGMNTLTLTIEDGVTTVAISPDTKYVAAGSLDKSVRVWDIKMGYLLERLEGPDGHKDSVYSVAFSPNARELVSGSLDKTIKMWELTAPRSVNQQGPLKGGRCIKTFEGHRDFVLSVALTPDAEWVLSGSKDRGVQFWDPRTGHTQLMLQGHKNSVISVAPSPVVSPTGGYFATGSGDMRARIWSYTRLDRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHQ9</accession>
    <name>G0SHQ9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0073040</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS16979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697561.1">
        <property type="nucleotide sequence ID" value="XM_006697498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHQ9"/>
    <dbReference type="STRING" id="759272.G0SHQ9"/>
    <dbReference type="GeneID" id="18261342"/>
    <dbReference type="KEGG" id="cthr:CTHT_0073040"/>
    <dbReference type="eggNOG" id="ENOG502SYCV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073109_0_0_1"/>
    <dbReference type="OMA" id="YYAKKHP"/>
    <dbReference type="OrthoDB" id="5235322at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS16979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="276" mass="30937" checksum="A3AF9A7E1ADED360" modified="2011-10-19" version="1">MGLIDDASSILSARTSHSKRSSKSHKRRHRERERERGRGLESDYYTSRAARSKSRSRSRSRSRSRSKHRSSKKSSKTGGGYVAALGGIASSILGFGGSGSDSDDEAFAYGEHYRDPAWEREYQRQREYRRSEREKGGGLFDMPDLTRSSFFSSFGRPSTPRASYYSRSPRPAFLKRLRKKFRRVTRDIQSYAERHPIQIFTLVILPLISGGYLTNFLAKLGLKLPKFVEKLLGVAAKAGRGDSIGAVNDAVRLVTNAAGRGGLSVSKYVKKEKGNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHT6</accession>
    <name>G0SHT6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NTF2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0073310</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697588.1">
        <property type="nucleotide sequence ID" value="XM_006697525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHT6"/>
    <dbReference type="GeneID" id="18261369"/>
    <dbReference type="KEGG" id="cthr:CTHT_0073310"/>
    <dbReference type="eggNOG" id="ENOG502SB73">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096573_1_0_1"/>
    <dbReference type="OMA" id="DTWQIKT"/>
    <dbReference type="OrthoDB" id="5596743at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058645">
        <property type="entry name" value="NTF2-like_dom_7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26534">
        <property type="entry name" value="NTF2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409211" description="NTF2-like domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="NTF2-like" evidence="2">
        <location>
            <begin position="31"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="171" mass="19101" checksum="68CB0BBD1A3BEAE4" modified="2011-10-19" version="1">MRFSSLIALLAGTALALPTGTLTPRQEEQACLTKDEAAEIVEIYRRLIAEYDPTDCEKYCAEDFVDRSDSINTFIHKPLGEPTFATKQIFMDAQLSNPPFPVVIDHIDAVDCEAIALRWHATFGAANLPSRGITIIGTTKREGYWQIKSLDVEFNSLIWLLNMGGSYVWEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHW2</accession>
    <name>G0SHW2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0073580</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697614.1">
        <property type="nucleotide sequence ID" value="XM_006697551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHW2"/>
    <dbReference type="STRING" id="759272.G0SHW2"/>
    <dbReference type="GeneID" id="18261396"/>
    <dbReference type="KEGG" id="cthr:CTHT_0073580"/>
    <dbReference type="eggNOG" id="KOG3480">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162151_1_0_1"/>
    <dbReference type="OMA" id="VGENMQK"/>
    <dbReference type="OrthoDB" id="274922at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038:SF16">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="13">
        <location>
            <begin position="16"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS17032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="89" mass="9724" checksum="2418F823A48A0A8E" modified="2011-10-19" version="1">MFGFGRPQPTSAEKIAAIENELKVVAEMHSRMIKVCSAKCLDKTYREGELSKGEAVCLDRCAAKFFEAHQIISDQLQKEGAARGFGGGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G0SI27</accession>
    <name>G0SI27_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative sequence-specific DNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0074260</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697679.1">
        <property type="nucleotide sequence ID" value="XM_006697616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SI27"/>
    <dbReference type="STRING" id="759272.G0SI27"/>
    <dbReference type="GeneID" id="18261464"/>
    <dbReference type="KEGG" id="cthr:CTHT_0074260"/>
    <dbReference type="eggNOG" id="KOG2294">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_437418_0_0_1"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881">
        <property type="entry name" value="CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881:SF5">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="8">
        <location>
            <begin position="253"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="253"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="179"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="351"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS17097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="625" mass="68189" checksum="34071C8287F2BAEA" modified="2011-10-19" version="1">MVSIEASNASPPRQVSQTSAPTDPTTTVATTTGEQIMATADMESLQSHNSQVMRSYLSSHSAAQSSEPIWSVCFEQQQANSSTDDCDNYALHSSPVMSSLNPATDRTSAQSSPRTWTTSPEQCNAINWEPAPEYTTLDPQFSYRPTSYPSRVPLVTSEEFHDIGRSHIETYPAGYYHNSPMDGAPPTPMSPCSSTLDLTAPDSIPSPPETAEDSDSRPASKDKIISSNSKSGHKKNQSGDIKNGSSTDGSGKKEDEPYAQLIYKAFLSTPRHAMTLQEIYQWFRENTDKGKDDSKGWQNSIRHNLSMNMAFTKRERRLSTSEDSKDGKDSASAKKSTEWYLEPWAVEQGVQSTTRYRKSNASRRNATLSSTASRSHHHHSSIYRHHAYLSTHPGSRKVVAATAATAGLLAAGSLGTSTRLRGSSPRSTPLRSNSTSAGSLAATAYHHQLQQIQHQQTQRYYQLLQQQHQLNAVHPVYVTRAAAAAGYFTRHDYEHQHHHETYHQQAHQQHQQYPTDPQLFPATPGPLTPEPSAFGGDGMLAMADIQAASINASGIVTTTVTTQGLPATPSPSPYHPLMYEGYASEHRVAEPWTAAVTSQSTQALAAVVTCEADTTNGTTVTTGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0RXS7</accession>
    <name>G0RXS7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0000240</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988030">
        <property type="protein sequence ID" value="EGS24093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690579.1">
        <property type="nucleotide sequence ID" value="XM_006690516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RXS7"/>
    <dbReference type="STRING" id="759272.G0RXS7"/>
    <dbReference type="GeneID" id="18254062"/>
    <dbReference type="KEGG" id="cthr:CTHT_0000240"/>
    <dbReference type="eggNOG" id="ENOG502QQNB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033094_0_0_1"/>
    <dbReference type="OMA" id="FYLFHNY"/>
    <dbReference type="OrthoDB" id="1461976at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03507">
        <property type="entry name" value="Delta12-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021863">
        <property type="entry name" value="FAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11960">
        <property type="entry name" value="DUF3474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase N-terminal" evidence="9">
        <location>
            <begin position="67"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="8">
        <location>
            <begin position="132"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="13"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS24093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="477" mass="54278" checksum="9073FC60F64D0899" modified="2011-10-19" version="1">MAANKPVQRRNLRSAAAEADSSASSAVVSPVDSPRPSASSTSLSSLASEDNKDLSQKQYPKLYDTYGNEFVPPDFTIKDIRDAIPKHCYERSAIRSLAYVARDIVYLSVTFYLWNKFVTLEYIPSKPVRAALWFAYTFLQGLFGTGIWVMAHECGHHAFSPYTKLNNFVGWILHSSLLVPYFSWQLSHSKHHKATGNMARDMVFLPRTREQHATRIGRMVHELSELTEEAPIVTLIHLIGQQLIGWWNYLLTNVTGHNNHERQREGRGKGKKNGLFGGVNHFSPNSPIFENRDVPYIILSDIGIALMISILVFCGKTFGWSNMLVWYFFPYMWVNHWLVAITYLQHTDPSLPHYTEEEWNFVRGAAATIDREFGFIGRHLFHGIIETHVLHHYVSTIPFYNADEATEAIKKVMGRHYRSDTREGPIGFIKAMWRAARWCQWVEPSEGAEGPAKGILFFRNHNGLGVPPAKIPPPTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>G0RY84</accession>
    <name>G0RY84_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CTHT_0005780</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="17">DSM 1495 / CBS 144.50 / IMI 039719</strain>
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    <reference evidence="18" key="2">
        <citation type="journal article" date="2016" name="Acta Crystallogr. F Struct. Biol. Commun." volume="72" first="112" last="120">
            <title>Structural and functional analysis of the RNA helicase Prp43 from the thermophilic eukaryote Chaetomium thermophilum.</title>
            <authorList>
                <person name="Tauchert M.J."/>
                <person name="Fourmann J.B."/>
                <person name="Christian H."/>
                <person name="Luhrmann R."/>
                <person name="Ficner R."/>
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            <dbReference type="PubMed" id="26841761"/>
            <dbReference type="DOI" id="10.1107/s2053230x15024498"/>
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        <scope>X-RAY CRYSTALLOGRAPHY (2.92 ANGSTROMS) OF 61-764 IN COMPLEX WITH ADP AND MG(2+)</scope>
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    <reference evidence="19 20 21" key="3">
        <citation type="journal article" date="2017" name="Elife" volume="6" first="e21510" last="e21510">
            <title>Structural insights into the mechanism of the DEAH-box RNA helicase Prp43.</title>
            <authorList>
                <person name="Tauchert M.J."/>
                <person name="Fourmann J.B."/>
                <person name="Luhrmann R."/>
                <person name="Ficner R."/>
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            <dbReference type="DOI" id="10.7554/elife.21510"/>
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        <scope>X-RAY CRYSTALLOGRAPHY (1.78 ANGSTROMS) OF 61-764 IN COMPLEX WITH ADP AND MG(2+)</scope>
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    <reference evidence="22 23" key="4">
        <citation type="journal article" date="2019" name="Nucleic Acids Res." volume="47" first="4349" last="4362">
            <title>Structural basis for RNA translocation by DEAH-box ATPases.</title>
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                <person name="Hamann F."/>
                <person name="Enders M."/>
                <person name="Ficner R."/>
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            <dbReference type="PubMed" id="30828714"/>
            <dbReference type="DOI" id="10.1093/nar/gkz150"/>
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        <scope>X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 61-764 IN COMPLEX WITH ADP AND MG(2+)</scope>
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    <reference evidence="24 25" key="5">
        <citation type="journal article" date="2025" name="Cell Res." volume="35" first="296" last="308">
            <title>Structural insights into spliceosome fidelity: DHX35-GPATCH1- mediated rejection of aberrant splicing substrates.</title>
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                <person name="Li Y."/>
                <person name="Fischer P."/>
                <person name="Wang M."/>
                <person name="Zhou Q."/>
                <person name="Song A."/>
                <person name="Yuan R."/>
                <person name="Meng W."/>
                <person name="Chen F.X."/>
                <person name="Luhrmann R."/>
                <person name="Lau B."/>
                <person name="Hurt E."/>
                <person name="Cheng J."/>
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        <text evidence="12">Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA.</text>
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            <text>ATP + H2O = ADP + phosphate + H(+)</text>
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        <source>
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        <source>
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        </source>
    </evidence>
    <sequence length="764" mass="87035" checksum="3FBF210CEE9BB600" modified="2011-10-19" version="1">MADITKGTKRLSGEAEGSQDSKRVKTNGDKMDAKNPYLAHLEEKPEADFESLLDKLERRNTTAKQAEAVEDSDINPWTGQRHSERYFKILKARRKLPVNKQRQEFLDLYHNNQILVFVGETGSGKTTQIPQYVLYDELPHQTGKLIACTQPRRVAAMSVAQRVADELDVKLGEEVGYSIRFENKTSSKTLLKYMTDGQLLREAMHDRDMSRYSCIILDEAHERTLATDILMALLKQLSERRKDLKIIVMSATLDAQKFQSYFFNAPLLAVPGRTHPVEIFYTPEAERDYVEAAIRTVLQIHACEPEGDILLFLTGEEEIEDACRRISLEVDEMIRESDAGPMSVYPLYGTLPPHQQQRIFEKAPQPFRPGGRPGRKCIVATNIAETSLTIDGIVYVVDPGFSKQKIYNPRTRVESLLVSPISKASAQQRAGRAGRTRPGKCFRLYTEEAFKKELIEQTYPEILRSNLSNTVLELKKLGVEDLVHFDLMDPPAPETMMRALEELNYLACLDDDGELTPLGNLASEFPLDPALAVMLISSPEFYCSNEILSITSLLSVPQIWVRPANARKRADEMKAQFAHPDGDHLTLLNAYHAYKGAEARGEDMKKWCHEHFLSYRHLSSADNVRAQLKKIMETHGIELVSTPFHDKNYYTNIRRALLAGFFMQVAMRESSNSKVYKTVKDEQLVLIHPSTTVTTPYEWVVYNEFVLTTKQYVRTVTNIRPEWLLEIAPVYYDLSTFQKGEIKNALTRVAEKIRRQQAMKASKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYU8</accession>
    <name>G0RYU8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plasma membrane fusion protein PRM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0000640</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Involved in cell fusion during mating by stabilizing the plasma membrane fusion event.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PRM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690618.1">
        <property type="nucleotide sequence ID" value="XM_006690555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYU8"/>
    <dbReference type="STRING" id="759272.G0RYU8"/>
    <dbReference type="GeneID" id="18254102"/>
    <dbReference type="KEGG" id="cthr:CTHT_0000640"/>
    <dbReference type="eggNOG" id="ENOG502QRP5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010191_1_0_1"/>
    <dbReference type="OMA" id="NVFGWVN"/>
    <dbReference type="OrthoDB" id="5356111at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032220">
        <property type="term" value="P:plasma membrane fusion involved in cytogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026777">
        <property type="entry name" value="PRM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31030">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN PRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31030:SF1">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN PRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0184">Conjugation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="621"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="652"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="699"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="670"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="711"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS23376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="720" mass="78728" checksum="4D6EE07D23A202FF" modified="2011-10-19" version="1">MVFHEKLGAVPPVPSSLNPNDWRTIPIHSDPSSSSSVQLPDHVNTAPSITPYLGLRARLSQLWFNRWTVLLILVLVRVLLLSGSLDDNIADAKVKALSACSKVEDIGSAMASMPHYLSVGVNSLASEGITKAVSGLVKVLIMILTGVENLLFFIINMYVGTFVCVVTALIHGGLDVAVKVVEGATKLMNNAVSGLTSQIEKIIDPAENFLESIESTKVLGKSVKDWLDLDMPDLSTVKKPLADLKNIKISSDDLVKDIKTLNQKIPTFDQIENLTKDAIAIPFDTLKKQINSTFGNYKFDDSVFPVAQKKALSFCSDNTFLNDFFDSLAEIVAKAKIAFLVIVPLLAVAAIVAMGWLEIRRWRRQMERAKGLSEHVYDPMDAVYMISRPMTSRFGIRIASFITSKRKYIILIRWAWAYTTSLPALFVLSLALAGFFSCFCQYIILQLLQKEVPALSTKVGDFTGQVVTTLQRVSTDWSNEANGVILKLQDDINNDLFGWVQEATSAVNNTLTTFDNEIDKGLNSAFKDTVLLQTAKDLVGCLIGRKIDAVQKGLTWVHDHAHVTLPLFAEDVFSRGANDSVSGDSDLTSFLASPSTVTTDEITAAVNRVIDKLRQSIVEEALISTALLLVYIIVVLIGILWAMANAVKRDKTRGEGGQEYGLKDVGASDSDGNSMSTSGWTPGAGYYAHTGSVKSGRSESARWLSLAQKNGHPEVQDSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZ69</accession>
    <name>G0RZ69_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endodeoxyribonuclease-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0001900</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690739.1">
        <property type="nucleotide sequence ID" value="XM_006690676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZ69"/>
    <dbReference type="GeneID" id="18254228"/>
    <dbReference type="KEGG" id="cthr:CTHT_0001900"/>
    <dbReference type="eggNOG" id="ENOG502S4DK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042191_0_0_1"/>
    <dbReference type="OMA" id="WDATMEI"/>
    <dbReference type="OrthoDB" id="5552842at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000402">
        <property type="term" value="F:crossed form four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070336">
        <property type="term" value="F:flap-structured DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039197">
        <property type="entry name" value="Mrs1/Cce1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015242">
        <property type="entry name" value="Ydc2_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28072">
        <property type="entry name" value="CRUCIFORM CUTTING ENDONUCLEASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28072:SF1">
        <property type="entry name" value="CRUCIFORM CUTTING ENDONUCLEASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09159">
        <property type="entry name" value="Ydc2-catalyt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="1">
        <location>
            <begin position="10"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="336" mass="37061" checksum="106846EBEFE5F5C2" modified="2011-10-19" version="1">MPRPSTPPRLLDETAVYIRALCSSCGLTQSGPKTLLVQRLRHAARRHKPLTSSSRILSIDLGLKNFAFCLLSPARSTKENKNHSMGALLNTPVHLHAWNRLDLTAAVQSFGARSSPLRPEPSSSPLEDIIAETQPSKKDQQEDTLPDDMFSPARLSLVTAHLVRTLLLPLRPTHVLIERQRFRTGGNAAVSEWTLRVGALEAMIHATLGTYRDILKDNQALSTAGSGKGLPTAQGSVTGGESALSLAAGLESVSSVVPKQGYLGGWEWRKMSRKEKAKKRKDGEVGENEEKWTQEKLDDLSDAVLQGLVWLQWQRNLEEIVRDWPELTEGQDTTDV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2024-01-24" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZB3</accession>
    <name>DAD2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Outer kinetochore protein DAD2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">DAD2</name>
        <name evidence="7" type="ORF">CTHT_0002350</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2018" name="Science" volume="360" first="552" last="558">
            <title>Structure of the DASH/Dam1 complex shows its role at the yeast kinetochore-microtubule interface.</title>
            <authorList>
                <person name="Jenni S."/>
                <person name="Harrison S.C."/>
            </authorList>
            <dbReference type="PubMed" id="29724956"/>
            <dbReference type="DOI" id="10.1126/science.aar6436"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (4.50 ANGSTROMS) OF 24-117</scope>
        <scope>IDENTIFICATION IN THE DASH COMPLEX</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the DASH complex that connects microtubules with kinetochores and couples microtubule depolymerisation to chromosome movement; it is involved in retrieving kinetochores to the spindle poles before their re-orientation on the spindle in early mitosis and allows microtubule depolymerization to pull chromosomes apart and resist detachment during anaphase. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and microtubules. Kinetochores also serve as an input point for the spindle assembly checkpoint, which delays anaphase until all chromosomes have bioriented on the mitotic spindle.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 2 4">Component of the DASH complex consisting of ASK1, DAD1, DAD2, DAD3, DAD4, DAM1, DUO1, HSK3, SPC19 and SPC34, with a stoichiometry of one copy of each subunit per complex (PubMed:29724956). Multiple DASH complexes oligomerize to form a ring that encircles spindle microtubules and organizes the rod-like NDC80 complexes of the outer kinetochore (PubMed:29724956). DASH complex oligomerization strengthens microtubule attachments (By similarity). On cytoplasmic microtubules, DASH complexes appear to form patches instead of rings.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DASH complex DAD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690783.1">
        <property type="nucleotide sequence ID" value="XM_006690720.1"/>
    </dbReference>
    <dbReference type="PDB" id="6CFZ">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.50 A"/>
        <property type="chains" value="C=24-117"/>
    </dbReference>
    <dbReference type="PDBsum" id="6CFZ"/>
    <dbReference type="AlphaFoldDB" id="G0RZB3"/>
    <dbReference type="EMDB" id="EMD-7469"/>
    <dbReference type="SMR" id="G0RZB3"/>
    <dbReference type="IntAct" id="G0RZB3">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0RZB3"/>
    <dbReference type="GeneID" id="18254273"/>
    <dbReference type="KEGG" id="cthr:CTHT_0002350"/>
    <dbReference type="eggNOG" id="ENOG502SG7I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138063_0_0_1"/>
    <dbReference type="OMA" id="QAINMAS"/>
    <dbReference type="OrthoDB" id="3230169at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0000305"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0000305"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0000305"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990758">
        <property type="term" value="P:mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990976">
        <property type="term" value="P:protein transport along microtubule to mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013963">
        <property type="entry name" value="DASH_Dad2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28036">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28036:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08654">
        <property type="entry name" value="DASH_Dad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0137">Centromere</keyword>
    <keyword id="KW-0158">Chromosome</keyword>
    <keyword id="KW-0159">Chromosome partition</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0206">Cytoskeleton</keyword>
    <keyword id="KW-0995">Kinetochore</keyword>
    <keyword id="KW-0493">Microtubule</keyword>
    <keyword id="KW-0498">Mitosis</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000459460" description="DASH complex subunit DAD2">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P36162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q9UTG8"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="29724956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="29724956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="EMBL" id="EGS23541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="10">
        <source>
            <dbReference type="PDB" id="6CFZ"/>
        </source>
    </evidence>
    <sequence length="138" mass="14779" checksum="231EE78F68FC90AF" modified="2011-10-19" version="1">MSGFSSRPLSTHLRQPSLAPPQGQSPALLARVNEKKAELENLKELRDLSAAVAAQMEALEQKLSTLSSGTEAIATVLANWHNVLRAISMASAKIPEPKEETEENTVPLPQTLVRIPTEHAPALQAHAEGATEEESGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZI4</accession>
    <name>G0RZI4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative checkpoint protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0003070</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad17/RAD24 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690854.1">
        <property type="nucleotide sequence ID" value="XM_006690791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZI4"/>
    <dbReference type="STRING" id="759272.G0RZI4"/>
    <dbReference type="GeneID" id="18254345"/>
    <dbReference type="KEGG" id="cthr:CTHT_0003070"/>
    <dbReference type="eggNOG" id="KOG1970">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006397_1_0_1"/>
    <dbReference type="OMA" id="YNKREDP"/>
    <dbReference type="OrthoDB" id="10265971at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004582">
        <property type="entry name" value="Checkpoint_prot_Rad17_Rad24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057927">
        <property type="entry name" value="RAD24-like_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03215">
        <property type="entry name" value="Rad17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25812">
        <property type="entry name" value="RAD24_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Checkpoint protein RAD24-like helical bundle" evidence="9">
        <location>
            <begin position="579"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="183"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="116"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="235"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS23612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="970" mass="105123" checksum="48C97CE008AC02C4" modified="2011-10-19" version="1">MAPPAKRRKRAIVESDDDEYMDNGPQQKAEHQYKDNTLTRFLSLSPEKKPPSTTASVPVDPSSPQPRKRAAAAVKTTKATTRSPNTSPIKTRTRATQQRKRKAEEDDKEKGGKSGNLLTLFSQQAQRSQSSLHSNGHGTSKTNKTAKAIVDDIISDPISVSDKDDIIDDDDDNIPLIRSSATAAPSSLASRAKAAQKRFASTAPSNTQQTSTQSAAGTLSSNTGGRRFLRPAPRSNGSQSSTLASTPATIPDGNDSRPWPERFAPADLDELAVHKRKVQDVRRWLDDVFSNRLRQRLLVLKGPAGSGKTTTVRLLARDMHCEVLEWRNPASSFGAVGMAGYQSAAAQFEEFLGRGGKFGQLDLEDEEESPLPPASSSATAAAGPGSGSEKKLILIEEFPNTFMRSSTGLIAFRSAVMQYLEANTPPMTSFGFGQPAGPITPIVMVVSETLLTTTSASADSFTAHRLLGPEILRHPGTGVIEFNPIAPTFMTKALELVVQKEARKSGRKRTPGPLVLQRLAEIGDIRNAISSLEFLCLKGDHEADWGSKVGFSRPKRGAKDLPALTKGEQESLELVSQREATLGIFHAVGKVVYNKREEFPSGSVGEQTERTLPPYMVHLARPKRSEVAVDSLMDEIGTDTHTFISALHENYALSCEQTGPMDPNSSLDYLNGCLDYLSDSDMLCPSWDVFFGGRGGFAGNAGYYGKDMGSHILRQDEMAFQVAVRGLLFSLPSPVKRLAHPTGRGGDAFKMFYPTYLKLWRTKEEIEGLVDVWATKMLKGEVGGPGPPPSQYSQLTGPSAFLFKSPSKRFPNTALAHHPKPQPPTVVTAVTSDHVRHSQPPPPLSLGTAARQELLLERLPYMTHIARRRRTYGTTHTRELERIVSFHGIGTLGAGEEEGEEAIADEEATGTGLVAGSVSEVVSWATDRPVEEPPPRKKGGLVSILRGSDDGLGCLSMQGLVISDDDIEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZK9</accession>
    <name>G0RZK9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0003320</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690879.1">
        <property type="nucleotide sequence ID" value="XM_006690816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZK9"/>
    <dbReference type="STRING" id="759272.G0RZK9"/>
    <dbReference type="GeneID" id="18254370"/>
    <dbReference type="KEGG" id="cthr:CTHT_0003320"/>
    <dbReference type="eggNOG" id="ENOG502S6V3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068499_0_0_1"/>
    <dbReference type="OMA" id="VKLWEDI"/>
    <dbReference type="OrthoDB" id="9626941at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013945">
        <property type="entry name" value="Pkr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28251">
        <property type="entry name" value="V-TYPE ATPASE ASSEMBLY FACTOR PKR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28251:SF1">
        <property type="entry name" value="V-TYPE ATPASE ASSEMBLY FACTOR PKR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08636">
        <property type="entry name" value="Pkr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="176" mass="19237" checksum="74E1BEA2B3B04664" modified="2011-10-19" version="1">MASFLHGLWESIFTPGPTPTLLVATNVTFAALQVILALLLLATWSIHFMVLSVLCGGLWAAINWFARELKEHQRQDEEKKRRALASRTAAVTLSSDDSETEVEAAPKSTASLRRSVPAPASAPAATSSEVEPTEAHGELKHRAVEESPRLSQGQKSCVSTEDEWEKVSEAENEKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZS9</accession>
    <name>G0RZS9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Copper acquisition factor BIM1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0004060</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690949.1">
        <property type="nucleotide sequence ID" value="XM_006690886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZS9"/>
    <dbReference type="GeneID" id="18254444"/>
    <dbReference type="KEGG" id="cthr:CTHT_0004060"/>
    <dbReference type="eggNOG" id="ENOG502SIF7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1749425_0_0_1"/>
    <dbReference type="OMA" id="PQSAWAV"/>
    <dbReference type="OrthoDB" id="5329488at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046936">
        <property type="entry name" value="BIM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046530">
        <property type="entry name" value="BIM1-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992:SF10">
        <property type="entry name" value="COPPER ACQUISITION FACTOR BIM1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20238">
        <property type="entry name" value="BIM1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Copper acquisition factor BIM1-like" evidence="8">
        <location>
            <begin position="30"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS23707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="149" mass="15835" checksum="39BB67174CE61E36" modified="2011-10-19" version="1">MGFGTDGPHGGPQNMSFPMIPPFQILGPHKNPYPGTVCLPQVPLPANTTVKPGDKATIQIVELAVHGAALYSCVDIIFAEPGDPRIPEVNETNCFNSTDIGVADIYTLTLRASGEDPNAPRTSGASLENYRFLGHLPLLLVGLAAWMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZW2</accession>
    <name>G0RZW2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acetyl-coenzyme A synthetase</fullName>
            <ecNumber evidence="3">6.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Acetate--CoA ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Acyl-activating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0004420</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="3"/>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690982.1">
        <property type="nucleotide sequence ID" value="XM_006690919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZW2"/>
    <dbReference type="STRING" id="759272.G0RZW2"/>
    <dbReference type="GeneID" id="18254480"/>
    <dbReference type="KEGG" id="cthr:CTHT_0004420"/>
    <dbReference type="eggNOG" id="KOG1175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_293724_0_0_1"/>
    <dbReference type="OMA" id="AIKASWP"/>
    <dbReference type="OrthoDB" id="1706066at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05966">
        <property type="entry name" value="ACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000004">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000001">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001208">
        <property type="entry name" value="PRK00174.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095:SF14">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="14">
        <location>
            <begin position="408"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="12">
        <location>
            <begin position="466"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="13">
        <location>
            <begin position="914"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="60"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00082655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00082978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS23740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1034" mass="112628" checksum="93277FA1F809B16F" modified="2011-10-19" version="1">MQEYIVAGWHSEDPAEAKQGSGLQKSQRLSGLVPKSALWATPPDTMGPGFPPRAWPCRGETGRSSPTLVKEEGGLGQAQGCWKTEPEIGSQGIGTDQRRSRHKAQGTANSNAGTGDAMGVCRTEGKLTRAGRAASLPTYVVVLGATVIIPAGCYSITSVIAANLHREGESPPDHGTSSCVASAASVTHAGSASRWPKRPNLAGMPLVRVDVGHHTPHTPHTHAHTPSASSVSVSASASAGCWLWLLQKPRSRPVAPLVLTFPLSPLATALVANFFFASRWSSSLTSPAPHPSLSPSSTCARRISRRRCCGCRCRFSTFPGNPTLFCANTLADSSRSLPRHRAPPSLSLSQQPRHIRTLQTLSTTPKMSQGSPKAPVVAEAHEVDTYHPPKKMFAKHPSKPHLSGLEEYQKLYKESITQPDKFWGRLARELLTWHRDFQTVRSGSLVNGDVAWFLEGEINASYNCVDRHAFADPNRVAIIYEADEPTDGRSVTYGELLREVSRVAHVLKAMGVRKGDTVAIYLPMIPEAVVALMACARIGAIHSVVFAGFSADSLRDRVLDARCKVVITTDEGKRGGKLIGTKKIVDEALKQCPEVKHVLVYKRTGADIPMTPGRDLWWHEEVQKYPNYIPPEPMNSEDPLFLLYTSGSTGKPKGVMHTTGGYLVGAAATGKYVFDIHPGDRYFCGGDVGWITGHTYVVYAPLLLGVTTVVFEGTPAYPNFSRYWDIIEKHGVTQFYVAPTALRLLKRAGDQFVKGDFNKHLRVLGSVGEPIAAEVWKWYFEVVGKEEAQVVDTYWQTETGSHVIAPLAGVTPTKPGSASLPFFGIEPAIIDPVSGEEIHGNDVEGVLAFKQPWPSMARTVWGAHKRYMETYLNVYKGYYFTGDGAGRDHEGFYWIRGRVDDVVNVSGHRLSTAEIEAALIEHPIIAEAAVVGVADELTGQAVNAFVSIKEGHEASDALRKEFILQVRRSIGPFAAPKAVYIVPDLPKTRSGKIMRRILRKVLAGEEDQLGDVTTLSDPSVVGRIIDVVREARRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G0S097</accession>
    <name>G0S097_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">GPN-loop GTPase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0009250</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691449.1">
        <property type="nucleotide sequence ID" value="XM_006691386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S097"/>
    <dbReference type="STRING" id="759272.G0S097"/>
    <dbReference type="GeneID" id="18254963"/>
    <dbReference type="KEGG" id="cthr:CTHT_0009250"/>
    <dbReference type="eggNOG" id="KOG1534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037460_0_0_1"/>
    <dbReference type="OMA" id="LYTHMTV"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17872">
        <property type="entry name" value="GPN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000552">
        <property type="entry name" value="GPN-loop GTPase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030228">
        <property type="entry name" value="Gpn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF7">
        <property type="entry name" value="GPN-LOOP GTPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS23258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="297" mass="33094" checksum="660A360E53AC4F33" modified="2011-10-19" version="1">MSKYGVMVMGPAGVGKSTFCAALITHLQLNRRSAFYVNLDPAAEHFEHQPDLDIRDLISVDDVMDELKLGPNGGLIYCFEFLMENLDFLTEALDSLTEEYLIIFDMPGQVELYTHIPILPRLVKFLTQPGALDIRLCAAYLLEATFVLDRAKYFAGSLSAMSAMLMLEVPHLNILSKMDLIKDQLRKKDLKRFITPDPSLLDDDPADAGRKRAGVTIDPHSADPKDKDALMSGATFKRLNSAVAGLLETFGMVSYLKLSSNDEESVGAILSYIDDVIQFHEAQEPKEIPDPEYEDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0F1</accession>
    <name>G0S0F1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative calcium ion binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0009800</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691503.1">
        <property type="nucleotide sequence ID" value="XM_006691440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0F1"/>
    <dbReference type="STRING" id="759272.G0S0F1"/>
    <dbReference type="GeneID" id="18255018"/>
    <dbReference type="KEGG" id="cthr:CTHT_0009800"/>
    <dbReference type="eggNOG" id="KOG0037">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051357_0_1_1"/>
    <dbReference type="OMA" id="YNKSYNP"/>
    <dbReference type="OrthoDB" id="186625at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048306">
        <property type="term" value="F:calcium-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16180">
        <property type="entry name" value="EFh_PEF_Group_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051426">
        <property type="entry name" value="Peflin/Sorcin_CaBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212:SF3">
        <property type="entry name" value="GH27120P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212">
        <property type="entry name" value="PEFLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="195"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS23312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="297" mass="33830" checksum="B4130B1B0CE363A3" modified="2011-10-19" version="1">MAYNRPYNPDELPRFAEPATLKEPGPGPAPSQYHHAPPPQPPPGPSRYENRPPPPRPLEHRAQTFSDLYGAPNYQQGRLSPRMAAAPPDRERYGMSPPPQAAPTRPHPQNLPPTSSRPPPSPTERGSSADPTLLPLFRAVDKDGTGQLSERELSAALVNGDWTAFDPQTVRMMIRMFDSDRSGTIGFEEFCGLWSFLASWRSLFDRFDVDRSGNISLDEFRNALVAFRYRLSDRFTELLFRTYDKRGEGVMSFDLFVQACISLKRMTDVFKRYDDDRDGYITLSFEDFLTEILRQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0R9</accession>
    <name>G0S0R9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0011010</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691621.1">
        <property type="nucleotide sequence ID" value="XM_006691558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0R9"/>
    <dbReference type="STRING" id="759272.G0S0R9"/>
    <dbReference type="GeneID" id="18255139"/>
    <dbReference type="KEGG" id="cthr:CTHT_0011010"/>
    <dbReference type="eggNOG" id="KOG2111">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025895_0_0_1"/>
    <dbReference type="OMA" id="SDARWEM"/>
    <dbReference type="OrthoDB" id="1667587at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="293"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="362"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="362"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS22629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="445" mass="47504" checksum="6D86019AF4CD59C2" modified="2011-10-19" version="1">MNTRTPLEGPSQTVVLSISFNDDCSCFAVGLNTGFCNNASLRMTRDFNAGIGLVQMMGKANFVGLVGGGRQPKFASNKASLLTIIPFITRTLLLTLVVQLVLWDDSRNKVALEISALTPVRGVQLSKERVVVVLQNSVRVYRFAKPPSLLTAYETANNPWGLCCLSPRRLAFPGRTTGHVQLVELSSGNVSIIPAHSSAIRALALSSDGELLATASEMVYPPVHPLKPLSSPRLTTTKGTLIRVWATSNCARLAELRRGIDPATIFSLAFNPSATMLACTSDKSTLHIFDVPNPNRPSRPTQQPTALAGVPGIPSAANGAPETAISTTNGSNRGKWGFLAKLPMMPRVFKDVYSFASAPFASDDGASSEGSSTSSRMLGGLPMSESTTLGTSRPPKGIIGWLTDDVLLVVGAGADPRWEKFVVVEGPDGRRGLLRQGWKRYLGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0Y1</accession>
    <name>G0S0Y1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0011640</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691683.1">
        <property type="nucleotide sequence ID" value="XM_006691620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0Y1"/>
    <dbReference type="STRING" id="759272.G0S0Y1"/>
    <dbReference type="GeneID" id="18255202"/>
    <dbReference type="KEGG" id="cthr:CTHT_0011640"/>
    <dbReference type="eggNOG" id="ENOG502S1ZS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031989_1_0_1"/>
    <dbReference type="OrthoDB" id="5393057at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21383">
        <property type="entry name" value="GAT_GGA_Tom1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAT" evidence="2">
        <location>
            <begin position="193"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="450" mass="49412" checksum="79F01B401BDB296A" modified="2011-10-19" version="1">MGSFSMNKVLGTLKKRPTAGSKAILHVCGKRFGTCIAQGDDVVFLPSIVESAVASPAAAAECARRIRKYMSKDYWTKPACQYNAIMLARILANNPGPGFTRFLDKKFIEATKELLRSCRDASVLQMLMETLDAFEHEKYGDENLRPLIEMWKKEKEKARQAYGGVVLVPPPPPVNPQPPHGYHRHGSHSKRLPDPVELASRLEEARTSAKLLEQVIACTPSNEILSNDLIKEFAGRCTRASRSIQGYMTAQNPAPDVDTMESLIDTNEQLQKALNLHHRAILRAKKQLTESQTQGTSNLAVPGSSSGSSPNPQLQTQSQQPSSPTSRLLAILPSRMPVSTSRGSEIQKSKSRNHDEYVPDSAMSGARHSVTNDDDNLQNPFRDPDPEVSCTVGRSMRFPDEPFHPGFGHNSGGNRATAAAGQQRPSTPVYNRDDDGSDLYSATPPRKRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1N6</accession>
    <name>G0S1N6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CTHT_0014250</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691938.1">
        <property type="nucleotide sequence ID" value="XM_006691875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1N6"/>
    <dbReference type="STRING" id="759272.G0S1N6"/>
    <dbReference type="GeneID" id="18255463"/>
    <dbReference type="KEGG" id="cthr:CTHT_0014250"/>
    <dbReference type="eggNOG" id="KOG0591">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_23_1"/>
    <dbReference type="OMA" id="AYFERDH"/>
    <dbReference type="OrthoDB" id="10250725at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08217">
        <property type="entry name" value="STKc_Nek2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000697">
        <property type="entry name" value="G2-specific protein kinase nimA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000525">
        <property type="entry name" value="Serine/threonine-protein kinase KIN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF10">
        <property type="entry name" value="NIMA-RELATED KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="7"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="405"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="529"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="590"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="796"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="291"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="418"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="536"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="594"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="627"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="674"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGS22946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="822" mass="91494" checksum="3F0753331E9EF342" modified="2011-10-19" version="1">MSENDEYEVLEKIGHGSFGIIRKVRRKADGKIMCRKEISYLKMTQKEREQLHAEFQILSSLRHPNIVGYYHREHLKATQDLHLYMEYCGNGDLGRVIRDLAAKNQYAEEWFVWSIFTQLVTALYRCHYGVDPPEVGKSILGIPAQRPKPPPGAMTILHRDLKPENVFLGEDNSVKLGDFGLSKVMESHDFASTYVGTPFYMSPEICAAEKYTLKSDIWSLGCIIYELCTREPPFNAKTHYQLVQKIKEGKINPLPAVYSQELFSIIKDCLRVNPDRRPDTATLLNLPVVRLMRKEREVNDFNKTLKQKEESLNRRVKEVEQKAAALEQKAAALQQEKAALEQQKVALEQQKTAMRQEIEAAVRREWEVKARLEIDRLVALEIEQLHKKFEQEVQLRVEMELQKRKATIPSEADRTDLSSSASGASSSISGRSADSEQTSTTDATDLTVESPDTSMHPLKRSVTRTPFTRAHTMFAAPVGTPMDIEMASPSPMTVQSLSLSPRRNFLAKPPTVNPGNIFAMAGESKDGAARRSLADSDTDADVDVDDANIDDDDIVPSPTRLIKHSNKNPFNPKQRPQLPAQQTVLPFHQRLKSKQSTATQGKTVTPAPSNSDFSSIRPVDSGVALQDRSNSPTRRVTKIPSTINMRNNATETATSGSGLLRKPSLSKKDSCDHQSQNSQNINPSQPSCLNKIYSAPNSIKSAASVPSITTATSCGNIRGRTLVELQQARAGGRPLSAVMSSDGHNPNCAHHHHHHHNHTHTHVVTNTSSPVRAFREHAAAANRGIVPVTTASALASEPPAVWDPEKDDMPSPFLVRRKPVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0S201</accession>
    <name>G0S201_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0015460</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS23061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692053.1">
        <property type="nucleotide sequence ID" value="XM_006691990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S201"/>
    <dbReference type="GeneID" id="18255584"/>
    <dbReference type="KEGG" id="cthr:CTHT_0015460"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_4_1"/>
    <dbReference type="OMA" id="CLLHSCE"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF61">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="372" mass="40320" checksum="F3457E8BCF057F47" modified="2011-10-19" version="1">MLFKLNIELFPLPFPLASSDSFQREYASVHHKFFPFDHVYLDSKAQLALLATPAHCAGKTYIVTGANSGLGFHAALHLAKLGAGRLILAVRNLAAGEEAKARILSAVPDAKTVIEVWSLDLAKYNTIVQFANRAERELERIDGLIENAGVCPGKREIAEGRVSAITVNVVGTLLLLALMLPGMGRKAKKYGEVARLVVVSSSLGFQDWVKGALEGIKGEQGLLAAVDKGEGEYETMKVYALSKLLLTFATRYIARFLVPDPTKSGVIITTVCPGLCDTGLPRYAPPEVQAPALKLIEQCGRTAEDGSRTLLHGTVAGIESHGRFLQHCEEGDDIPDWIRDDVGMQRKIWDDVARDLEDASPGVIDHLLAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>G0S218</accession>
    <name>G0S218_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0015650</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS23078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692070.1">
        <property type="nucleotide sequence ID" value="XM_006692007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S218"/>
    <dbReference type="GeneID" id="18255603"/>
    <dbReference type="KEGG" id="cthr:CTHT_0015650"/>
    <dbReference type="HOGENOM" id="CLU_1855048_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="138" mass="14750" checksum="71C4F5A342D51472" modified="2011-10-19" version="1">MSAKAYSTDSSVEGIRTPSSGIISSSDQDDAFSIEDGSMPVVITMAGSSLGPHSGSDAHNSGATNPGLSATFPMRWALQRYLAESAIIEGPLYGRFLEAQMQTDNSIPSPYERVGFYATLAMRAIDQFEATFPDHVHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G0S246</accession>
    <name>G0S246_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP citrate synthase</fullName>
            <ecNumber evidence="2">2.3.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ATP-citrate (pro-S-)-lyase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Citrate cleavage enzyme subunit 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CTHT_0015950</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the formation of cytosolic acetyl-CoA, which is mainly used for the biosynthesis of fatty acids and sterols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>oxaloacetate + acetyl-CoA + ADP + phosphate = citrate + ATP + CoA</text>
            <dbReference type="Rhea" id="RHEA:21160"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.3.3.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Composed of two subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.8" evidence="2"/>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS23106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692098.1">
        <property type="nucleotide sequence ID" value="XM_006692035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S246"/>
    <dbReference type="STRING" id="759272.G0S246"/>
    <dbReference type="GeneID" id="18255633"/>
    <dbReference type="KEGG" id="cthr:CTHT_0015950"/>
    <dbReference type="eggNOG" id="KOG1254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006587_4_1_1"/>
    <dbReference type="OMA" id="HMLRYQA"/>
    <dbReference type="OrthoDB" id="3261737at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003878">
        <property type="term" value="F:ATP citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06100">
        <property type="entry name" value="CCL_ACL-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000003">
        <property type="entry name" value="ATP-citrate synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000005">
        <property type="entry name" value="ATP-citrate synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000024">
        <property type="entry name" value="Probable ATP-citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118:SF42">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA-binding" evidence="19">
        <location>
            <begin position="37"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00054002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00060724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00062455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00076189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGS23106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="659" mass="72233" checksum="269AB528B25FFA53" modified="2011-10-19" version="1">MASPAPAAPAGGLSANDKITRFPAPSRPHSPLPAHALFNEKTRCFVYGMQPRAVQGMLDFDFICKRQVPSVAAIIYTFGGQFVSKMYWGTSETLLPVYQQVEKAMAKHPDVDVVVNFASSRSVYSSTMELMQYPQIKTIAIIAEGVPERRARELAYVAKKKGVTIIGPATVGGIKPGCFKIGNTGGMMDNIVASKLYRKGSVGYVSKSGGMSNELNNIISQCTDGVYEGIAIGGDRYPGTTFIDHLLRFQADPECKILLLLGEVGGVEEYKVIDAVKKGLITKPIVAWAIGTCASMFKTEVQFGHAGAFANSQLETAAMKNKMMREAGFYVPDTFEDLPKVLKELYEKLVKEGTIKPRPEPPVPKIPMDYSWAQELGLIRKPAAFISTISDDRGQELLYAGMPISDVFKENIGIGGVMSLLWFRRRLPDYATKFLEMVLMLTADHGPAVSGAMNTIITTRAGKDLISSLVSGLLTIGSRFGGALDGAAEEFTRAFDKGLSPREFVDSMRKQNKLIPGIGHRVKSRNNPDLRVELVKEYVKAHFPSTKMLDYALAVETVTTSKKDNLILNVDGCIAVCFVDLLRNCGAFSPEEAEDYLKMGVLNGLFVLGRSIGLIAHHLDQKRLRTGLYRHPWDDITYLLPNLQQTGPPGQEGRVEVQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2F2</accession>
    <name>G0S2F2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor 100 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0017020</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692204.1">
        <property type="nucleotide sequence ID" value="XM_006692141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2F2"/>
    <dbReference type="STRING" id="759272.G0S2F2"/>
    <dbReference type="GeneID" id="18255740"/>
    <dbReference type="KEGG" id="cthr:CTHT_0017020"/>
    <dbReference type="eggNOG" id="KOG1135">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002227_3_0_1"/>
    <dbReference type="OMA" id="QSRHNME"/>
    <dbReference type="OrthoDB" id="64353at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16293">
        <property type="entry name" value="CPSF2-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027075">
        <property type="entry name" value="CPSF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025069">
        <property type="entry name" value="Cpsf2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035639">
        <property type="entry name" value="CPSF2_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922:SF1">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13299">
        <property type="entry name" value="CPSF100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Beta-Casp" evidence="6">
        <location>
            <begin position="289"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="533"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="627"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="853"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="534"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="647"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="699"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="858"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS22185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="998" mass="107898" checksum="C41D832A8FA111BE" modified="2011-10-19" version="1">MFSFTPLLGARSESTASQSLLELDGGVKVLIDVGWDESFDPSLLRELEKHVPTLSLILLTHATINHLGAYAHCCKHFPLFTRIPVYATRPVIDLGRTLTQDLYASNPRAATTIPKSSLAETAFAFPQAAGGAELPSSLLLQPPTPDEIIRYFSLIQPLKYSQPHQPLPSPFSPPLNGLTITAYNSGHSLGGTIWHIQHGLESIVYAVDWNQARENVFAGAAWLGGGHGAAVGTEVIEPLRKPTALVCSSRTPDAALPRARRDEQLLESVKLCIARGGTVLIPVDSSARVLELAYLLEHAWRTEVAKENEVFKGTKLYLAGRSVGSTMRNARSMLEWMDDSIVREFEAVAGGARTTNGGANASGGNKAKEAGPFDFKYLRLLERKAQIERVLQQATSPPEGESPKGTVILATDTSLDWGFSKDVLKAIASDARNLVILTEKPNLANPDRPSIARMLWDWWRERRDGVAVEQTASGDTFEQVYGGGRELSVPESTRHPLEGSELTVYQQWLATQRQLQATLRSGGAAGALEASADVVDDASETTTESEESETEQQGKALNVSTTIGQASRKKVVLTDEDLGITILLKKKGVYDFDVRNKKGRERMFPTVLRRKRVDEFGELIRPEDYLRAEEREDEADAAAAANTQDASKPEHNLGKKRKFDDVAAATANTTSPAKRPARRGSIDEGDGALSGPASSDGQPGDELDELEDDEEAVLGPAKLVVAQQTVQVHLRIAFVDFSGLHDKRSLNMLIPLIQPRKLILVGGTEEETLSLAEDCRNLLGAAPSQPEGAEAMPTKTVSADIFTPLLNETINASVDTNAWSVLLTDSFVKHLKWQTVRGLGIVTVTGLLLPPGVEPLSQPAQQQQPQEPDSKRAKLDLSLPVPLTTPETANRSLPTLDILPPQLAGATVRSGGVQPLHVGDLRLADLRRGLLAAGHRAEFRGEGTLLVDGSVVVRKTGAGRVEVESIGLGVNQEEKGGWGTLLAVRRRIYEGLAVVGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2L5</accession>
    <name>G0S2L5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GEgh 16 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0017650</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692267.1">
        <property type="nucleotide sequence ID" value="XM_006692204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2L5"/>
    <dbReference type="STRING" id="759272.G0S2L5"/>
    <dbReference type="GeneID" id="18255803"/>
    <dbReference type="KEGG" id="cthr:CTHT_0017650"/>
    <dbReference type="eggNOG" id="ENOG502SJ8E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047729_1_1_1"/>
    <dbReference type="OMA" id="ANIVNQC"/>
    <dbReference type="OrthoDB" id="3241054at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021476">
        <property type="entry name" value="Egh16-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618:SF3">
        <property type="entry name" value="GEGH 16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618">
        <property type="entry name" value="SURFACE PROTEIN MAS1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11327">
        <property type="entry name" value="Egh16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408771" description="GEgh 16 protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="37144" checksum="E00B499513BD9074" modified="2011-10-19" version="1">MFSQLLPLAALVALTNAHGVILAAQGEPGSPPSVGFRVSDAIARNCTQINPCQQDTTIIRDEEIAAGVVNSCGRTKLTGNIDVGEVTENALAAGAVTQVKAGTKLTVTIHQVNADGAGPYFCDLDEGSNSGIMSKNLTVTNNVPGSNGLSQAQAQDFNITVELPADMRCIGASTGNVCTVRCRNNALAGPFGGCFAVQQIDVEPFNVAHTPGEVKTAETLEEVDFQMINNQAALPAAIEANKKAGTDEQAKNLAAVEAILGLTTTSASFPTLTPTIVQNSAATSTTSSAAAATTTASGRGRNRGNGRNNNNNNNNNNNNNNNNNNANTNAEETDTTAESGNGSGNRFGQFGRRAFPFWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2T6</accession>
    <name>G0S2T6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0018430</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692338.1">
        <property type="nucleotide sequence ID" value="XM_006692275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2T6"/>
    <dbReference type="STRING" id="759272.G0S2T6"/>
    <dbReference type="GeneID" id="18255881"/>
    <dbReference type="KEGG" id="cthr:CTHT_0018430"/>
    <dbReference type="eggNOG" id="KOG1269">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1660534_0_0_1"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF11">
        <property type="entry name" value="GERANYL DIPHOSPHATE 2-C-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="2">
        <location>
            <begin position="69"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="159" mass="18409" checksum="1C3880EF9B1F5D2D" modified="2011-10-19" version="1">MYWAVSSSIYACDPSKTAVIDYDAITWPTEEERREREKHYDEIAADYYHLVSQSYERGCRLEKGMRVIDLGWGLGNPARNTVLYMGCEIVGVTNSLWNVERGTLLAKLELPFPDASFDAAYFIETLCYSLNLELVYREVERMLKPGALFTFRDFTMTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2023-02-22" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2Y8</accession>
    <name>G0S2Y8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0018970</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692390.1">
        <property type="nucleotide sequence ID" value="XM_006692327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2Y8"/>
    <dbReference type="GeneID" id="18255935"/>
    <dbReference type="KEGG" id="cthr:CTHT_0018970"/>
    <dbReference type="HOGENOM" id="CLU_2687613_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="74" mass="8038" checksum="CA17F525723AAD3B" modified="2011-10-19" version="1">MVALNGRRFDTLKTMTQAELCECIHSSRLQQLANNAVGLAQAALDDDAAILLGKSHRDRTSGDSSADYKNVRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2023-02-22" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>G0S366</accession>
    <name>G0S366_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0019840</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692468.1">
        <property type="nucleotide sequence ID" value="XM_006692405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S366"/>
    <dbReference type="GeneID" id="18256022"/>
    <dbReference type="KEGG" id="cthr:CTHT_0019840"/>
    <dbReference type="HOGENOM" id="CLU_1948588_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS22449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="129" mass="13991" checksum="412F72A4BAB7D37E" modified="2011-10-19" version="1">MDSLDILAATHAQMGRAIPQRGHECRVSALEPGLCAHDASFAGHKVICLLRPQRMAQVMRIVNSTVAGTAIGVHVGEVAGNVNNENPGLWPSNHLALGGAQYWPFPDTFDRRRLRRPVCILCLVAGSTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0S368</accession>
    <name>G0S368_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0019870</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692470.1">
        <property type="nucleotide sequence ID" value="XM_006692407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S368"/>
    <dbReference type="STRING" id="759272.G0S368"/>
    <dbReference type="GeneID" id="18256025"/>
    <dbReference type="KEGG" id="cthr:CTHT_0019870"/>
    <dbReference type="eggNOG" id="KOG1337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010578_0_0_1"/>
    <dbReference type="OMA" id="WDIFCTL"/>
    <dbReference type="OrthoDB" id="42889at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19180">
        <property type="entry name" value="SET_SpSET10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044432">
        <property type="entry name" value="Set10/Efm1_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF146">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="499" mass="56818" checksum="BB4890110EE913AD" modified="2011-10-19" version="1">MREADRERFGRLLDWSQGHGAKLHENVEIYWDNVTRFSLRIKPSLKSSLEQLEPGFTAVTCPVSTTLSYLNALIDGPIMCDFTSNKPTVSSPPAFPPRFMDSLPPHVIGRFFLIKEYLKGENSFWWPYIATLPQPEQVNSWTLPAFWPEDDIQFLEGTNAHVAIGEIQANIKREYKQARKVLKEENFPNWKEYSQMLYKWAFSIFTSRSFRPSLILSQSVKDYVSTLLPSAREIDDFSILQPLFDIANHSMTATYTWDTTSDPNCCQLICQDSYRPGDQVFNNYGFKTNSELLLAYGFILPETDTLHNDYVHVRKRQQPEGENASKSDDQPKDFLISLRSMNDASSLAGKIRLTHTGLGSRFASLPAFAHFEPALVDDLASVISSQVPEVKDALEQWQNEKPTSEDRELPELIQDLVDRVKGALAGKLQYDYERLKQAEMEMAGENDELPPPCNSNQQLAIEYRMQCEKVLISALESLMEGEEIQDDGDGESDSSTSHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3A1</accession>
    <name>G0S3A1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0020260</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692503.1">
        <property type="nucleotide sequence ID" value="XM_006692440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3A1"/>
    <dbReference type="GeneID" id="18256064"/>
    <dbReference type="KEGG" id="cthr:CTHT_0020260"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_2_1_1"/>
    <dbReference type="OMA" id="QRKWAHA"/>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF6">
        <property type="entry name" value="CYTOCHROME P450 2C30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409266" description="Cytochrome P450" evidence="7">
        <location>
            <begin position="27"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS22484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="531" mass="61983" checksum="F714857DB1BB1CB5" modified="2011-10-19" version="1">MERVTLILLYLAIPSLLFSAIQKVLSWKNGSKPKAKFPGPRQFPLVGRIHDLPRFSLWLKFKEWADEFGPIYYTRAVENEFIIVTDEKIAEELLVKRGYIYSGRPQIRSLIKHKEGPAYSALMDRHDIWKTQRKWAHAAMAEAYKHHFYGHVEAEMKRYLGLLLLDPARFLDYTREYCGRVMSRLAWDDATQGRLNGESADTTLHCMSVSGPITNTVTPLWFLPSFINPWYKFEVKREREQRQWWINLFRIAKQRMLRGDLPSDTWAYRYFEQLRREGNVTLEQTKDQEDFASCMIGFLNLVGVVTISGPLKFYLMAMALHPHWQKKAQEEIDRVCGDRMPTMQDYEKLPIVRACLKETVRWRSGVPLGVPHQAERDDEYRGVKIRKGTIILACEWALNRVPTKYPDGDNFRPERWLEPGWPTYQEPLTRYPNFREGQAMHTFGFGRRTCLGQNIVDDETFVFGAAVLWAFNLGQKVCPCTGRPVPIDTQATNSHVILEPLPYEISIKVRSEERARQILDGYKEVQAQLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3V9</accession>
    <name>G0S3V9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0039060</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS22021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694317.1">
        <property type="nucleotide sequence ID" value="XM_006694254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3V9"/>
    <dbReference type="GeneID" id="18257944"/>
    <dbReference type="KEGG" id="cthr:CTHT_0039060"/>
    <dbReference type="eggNOG" id="ENOG502RKEX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1210518_0_0_1"/>
    <dbReference type="OMA" id="AYITARH"/>
    <dbReference type="OrthoDB" id="4578295at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS22021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="199" mass="22522" checksum="EF94D755B947AEA4" modified="2011-10-19" version="1">MTRSTYSSSHQAPDILLSPLSTKPRYRAYITARHAFWKCFPSGRYMRIPTGGTLTLECGLHALRLSIQHQLPHILPVPTVEELRSVYESSETIRIGNELTGMGNENWFTVDQLGVVFTEWGRQAVKERRVRCQLGYVAEGEWPVLLGTPEVGVGEEEGESNEEKGEIVRVWVWNDGLSLAGGVGHFEGMRRPIEEELRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0S443</accession>
    <name>G0S443_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NECAP PHear domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0030630</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693513.1">
        <property type="nucleotide sequence ID" value="XM_006693450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S443"/>
    <dbReference type="STRING" id="759272.G0S443"/>
    <dbReference type="GeneID" id="18257101"/>
    <dbReference type="KEGG" id="cthr:CTHT_0030630"/>
    <dbReference type="eggNOG" id="KOG2500">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069884_0_0_1"/>
    <dbReference type="OMA" id="NEGHRAQ"/>
    <dbReference type="OrthoDB" id="10265489at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012466">
        <property type="entry name" value="NECAP_PHear"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12847">
        <property type="entry name" value="ATP-BINDING CASSETTE ABC TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12847:SF9">
        <property type="entry name" value="NECAP-LIKE PROTEIN CG9132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07933">
        <property type="entry name" value="DUF1681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NECAP PHear" evidence="2">
        <location>
            <begin position="22"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS21217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="280" mass="30087" checksum="A689939ABEF89960" modified="2011-10-19" version="1">MDPSTAIIDPATDQPLPPDAIVRVLFLTHPVHVYSIPSTVVPSKAGYAASSWTDDPRNHIFTARLRILETSYTLESTQDSLADETQDPDPVLKVDILLEDPNTGVLFAAAPYVNKAVVEPTTDSSRFFTLRVQDPKSKVKATLAIGFEERSDAFDFGVALQEAAKSLGWQRTATGKGDSTTGDKATAQAEAKDYSLKEGETITINLKGTRFGRRTGQTQGGGEGGEVKQQQEEEGKPLAAFALAPPPPPPPGSSAAREARQRKRLSAQLGFDDGKFGEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4J9</accession>
    <name>G0S4J9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative GTP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0031270</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693570.1">
        <property type="nucleotide sequence ID" value="XM_006693507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4J9"/>
    <dbReference type="STRING" id="759272.G0S4J9"/>
    <dbReference type="GeneID" id="18257165"/>
    <dbReference type="KEGG" id="cthr:CTHT_0031270"/>
    <dbReference type="eggNOG" id="KOG0393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_21_2_1"/>
    <dbReference type="OMA" id="NDNVMRR"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000573">
        <property type="entry name" value="RHO family GTPase Rho2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS21274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="201" mass="22269" checksum="A4C7C33A51628A9F" modified="2011-10-19" version="1">MANDRNAQNVIRRKLVIIGDGACGKTSLLSVFTLGYFPTHYIPTVFENYVTDCRVDGKSVQLALWDTAGQEDYERLRPLAYAKAHVILIGFSVDTPDSLDNVKHKWVVEANERCPGVPIILVGLKKDLRDDPVAIEEMRKKSLRFVSPQDGESMAKEIGARKYLECSSLSGEGVDDVFEAATRASLLMFEKNEGPGCCVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4P1</accession>
    <name>G0S4P1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">mRNA-capping enzyme subunit alpha</fullName>
            <ecNumber evidence="5">2.7.7.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">GTP--RNA guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">mRNA guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">CTHT_0023020</name>
    </gene>
    <organism evidence="28">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:67012"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.7.7.50"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:67013"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="23">Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic GTase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.50" evidence="5"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692766.1">
        <property type="nucleotide sequence ID" value="XM_006692703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4P1"/>
    <dbReference type="STRING" id="759272.G0S4P1"/>
    <dbReference type="GeneID" id="18256340"/>
    <dbReference type="KEGG" id="cthr:CTHT_0023020"/>
    <dbReference type="eggNOG" id="KOG2273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2386">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_292211_0_0_1"/>
    <dbReference type="OrthoDB" id="289314at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07895">
        <property type="entry name" value="Adenylation_mRNA_capping"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06867">
        <property type="entry name" value="PX_SNX41_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000011">
        <property type="entry name" value="mRNA-capping enzyme subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001339">
        <property type="entry name" value="mRNA_cap_enzyme_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013846">
        <property type="entry name" value="mRNA_cap_enzyme_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044106">
        <property type="entry name" value="PX_Snx41/Atg20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051079">
        <property type="entry name" value="Sorting_Nexin_Autophagy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46979">
        <property type="entry name" value="SORTING NEXIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46979:SF2">
        <property type="entry name" value="SORTING NEXIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03919">
        <property type="entry name" value="mRNA_cap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01331">
        <property type="entry name" value="mRNA_cap_enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0072">Autophagy</keyword>
    <keyword evidence="24" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0967">Endosome</keyword>
    <keyword evidence="17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="16" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="26">
        <location>
            <begin position="93"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="432"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="24">
        <location>
            <begin position="396"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="484"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00029909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00030702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00044624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="EGS20470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1043" mass="118320" checksum="E86480A07B8FC5E2" modified="2011-10-19" version="1">MWNDEDNNPYGGGFERRDSFASSVNPSSPTTRDYSHFEAPPQTPSSTGDDDAPPRNDYSDEEESQEDQDARDRGELVPRRKPGGYDSRVEQMLYENPEMPILITDAGKSQENGRYIVYTIKTGELIVRRRYSEFASLREALTRLHPTLIIPPIPEKHTMADYAANPTNAKQDQQIIDLRKRMLAVFLNRCRRMEAIRTDGVWWRFLDPNSSWNEVLHSHPIASIPKSILRAPPLDPANPTPGHMYLPIPSNSAKLKTPSASLDTGGAPVLARFPPENHNLGERELDPYFTAFESSIKELEALLTGPMEKVNRRTLSHLSSLASDLSEMGARYNAFALSEPAPTLAPAIERIGQAADSSYIATEELSSTLGASFAEPMRENAQFAGVIRNVLRYRILKRVQQEMTNEELNKKRQLLDQLERSEAEARRIEQYLASTTQVAPPPRRSSREAPTSGHRREGSVSGGAGAEDTASIDSDFPPTHGDFSSAPSASIGVPPAPPPAPTHRKAPSAASITSRIFGPLRHAVQGVVDADPEKTRRDTITRTREQIAQLEQAQIASAQDVKDASASVLKDLRRFQREKEEDLRRYMLAYAKSQIEWAKKNKETWEEARAEVEKIDESACLLPVQPVRGAIRGKASFDLAATATMDPDSHPIRDIANPGIKAQGQLLQSLRIEVAKLLGRHQISFPGAQPVSFARRHLEELRREDYYVCEKSDGIRYLLYLTEDEAGKECHYLIDRKNDYWWIHQRNLHFPMPHDYQAFHTGTLIDGELVMDTLPNGDKEPKFLVFDLLALDGKAGLLEKPLDKRLGYFKELVMKPYKALFAKYPQELPFQAFVVEMKEMQYSYGIEMMFREVLPSLKHQNDGLIFTCRTSPYQFGTDPHILKWKAPHDNTIDFRLRLVFREVEPATEEERAELAALGKKTFTDYDSMPEARLLVFRGSDRGQPEYEEFPEKLYLTEEEWETLKSWGDPLQDRVVECVLDEEKRWRLYRFRDDKTEANHISTVNSVLESIKDAVSEAELLAAAKGIKDGWKMRQAQQQQAQHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4Z4</accession>
    <name>G0S4Z4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Cation-transporting ATPase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CTHT_0032200</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="20 21 22" key="2">
        <citation type="journal article" date="2024" name="Nat. Commun." volume="15" first="9605" last="9605">
            <title>The structure and function of P5A-ATPases.</title>
            <authorList>
                <person name="Li P."/>
                <person name="Bagenholm V."/>
                <person name="Hagglund P."/>
                <person name="Lindkvist-Petersson K."/>
                <person name="Wang K."/>
                <person name="Gourdon P."/>
            </authorList>
            <dbReference type="PubMed" id="39505844"/>
            <dbReference type="DOI" id="10.1038/s41467-024-53757-6"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.20 ANGSTROMS) IN COMPLEX WITH ADP AND MG(2+)</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>[protein]-with a C-terminal TM segment(out) + ATP + H2O = [protein]-with a C-terminal TM segment(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66168"/>
            <dbReference type="Rhea" id="RHEA-COMP:16963"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:90782"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693661.1">
        <property type="nucleotide sequence ID" value="XM_006693598.1"/>
    </dbReference>
    <dbReference type="PDB" id="8OP3">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.41 A"/>
        <property type="chains" value="A=1-1328"/>
    </dbReference>
    <dbReference type="PDB" id="8OP4">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="A=1-1328"/>
    </dbReference>
    <dbReference type="PDB" id="8OP5">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.47 A"/>
        <property type="chains" value="A=1-1328"/>
    </dbReference>
    <dbReference type="PDB" id="8OP6">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.79 A"/>
        <property type="chains" value="A=1-1328"/>
    </dbReference>
    <dbReference type="PDB" id="8OP7">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.50 A"/>
        <property type="chains" value="A=1-1328"/>
    </dbReference>
    <dbReference type="PDB" id="8OP8">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.48 A"/>
        <property type="chains" value="A=1-1328"/>
    </dbReference>
    <dbReference type="EMDB" id="EMD-17039"/>
    <dbReference type="EMDB" id="EMD-17040"/>
    <dbReference type="EMDB" id="EMD-17041"/>
    <dbReference type="EMDB" id="EMD-17042"/>
    <dbReference type="EMDB" id="EMD-17043"/>
    <dbReference type="EMDB" id="EMD-17044"/>
    <dbReference type="SMR" id="G0S4Z4"/>
    <dbReference type="STRING" id="759272.G0S4Z4"/>
    <dbReference type="GeneID" id="18257258"/>
    <dbReference type="KEGG" id="cthr:CTHT_0032200"/>
    <dbReference type="eggNOG" id="KOG0209">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001828_4_1_1"/>
    <dbReference type="OMA" id="QKTKYVW"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140567">
        <property type="term" value="F:membrane protein dislocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07543">
        <property type="entry name" value="P-type_ATPase_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000049">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000054">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000071">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057255">
        <property type="entry name" value="2TM_P5A-ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047820">
        <property type="entry name" value="P5A-type_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF7">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE HELIX TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23143">
        <property type="entry name" value="2TM_P5A-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="20 21 22" id="KW-0002">3D-structure</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 21 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1113"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1192"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1231"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="domain" description="P5A-ATPase transmembrane helical hairpin" evidence="17">
        <location>
            <begin position="19"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="16">
        <location>
            <begin position="262"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1268"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="499"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="499"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24 25">
        <location>
            <position position="499"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="499"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="501"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="501"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="612"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="674"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="741"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="834"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24 25">
        <location>
            <position position="859"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="859"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="859"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="862"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="863"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF23143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGS21365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PDB" id="8OP3"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="21">
        <source>
            <dbReference type="PDB" id="8OP4"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="22">
        <source>
            <dbReference type="PDB" id="8OP5"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="23">
        <source>
            <dbReference type="PDB" id="8OP6"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="24">
        <source>
            <dbReference type="PDB" id="8OP7"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="25">
        <source>
            <dbReference type="PDB" id="8OP8"/>
        </source>
    </evidence>
    <sequence length="1328" mass="148929" checksum="DA983621A7C6C137" modified="2011-10-19" version="1">MAPLVDNPQIKSAELLRPLPLYQHAYVWPYVIVWPVFLRVYLTQELYDKYIGAQEWTFVWIISIVTFQTLTWLCTHWSVNLNALFTAKKASSIEDAQLIKVIPVANAGAADICKLVRDKVGDNKTNISFLFQKRRFLWYPERKAFSTLEFDIDAEPKPTLSKFQLSRGIESEDELKRLEQHYGTNTFDIPVPTFTELFKEHAVAPFFVFQVFCVGLWLLDEYWYYSLFTLVMLVVFESTVVWQRQRTLTEFRSMSIKPYPIYVYRLGKWTEIQSDKLLPGDLVSVTRTKEDSGVACDMILVEGTAIVNEAMLSGESTPLLKDSIQLRPGDAVLEVDGLDKNSLLWGGTKVLQITHGTAEEERPKPASGIPPPPDNGAMAVVTKTGFETSQGSLVRTMIYSTERVSANNTEALLFILFLLVFALAASWYVWDEGVRKDRKRSKLLLDCILIITSVVPPELPMELSLAVNTSLSALAKFAIFCTEPFRIPFAGRIDVACFDKTGTLTGEDLVVEGIAGLGLGHSGTDTPKEADGAHTRMVSVHDAGMETTLVLATAHALVKLDEGEIVGDPMEKATLNALGWVLGKNDTLTSKPGNAASSGILGTVQIKRRFQFSSALKRQSSVATITATEVKTGRKLRGSFVGVKGAPETIMKMLVTVPEHYEETYKYFTRRGSRVLALAYKQLTTEGELGANKINDLKRESVEADLHFAGFLVLQCPLKEDAKQAVRMLNESSHRVVMITGDNPLTAVHVAKEVEIVDRDVLILDAPEHSVYGEESLVWRSVDDKIRIDVDPTKPIDPEILKTKDLCVTGYALNKFKGQVGWKSLLRYTWVYARVSPKQKEDILLGLKDMGYYTLMAGDGTNDVGALKQAHVGVALLNGTQEDLNRIAEHTRNQKMKELYQKQVDLMARWGQPPPPVPAMIAHLYPPGPSNPHYQKAMEREAQKRGVTVEQLAKVNGTNVTSNPAGVQQQSGQDAKKAKQVEAAKKAANFADKLTSSLMEAEMDDEPPTLKLGDASVAAPFTSKLRNVMAIPNILRQGRCTLVATIQMYKILALNCLISAYSLSVLYLEGIKFGDGQITISGMLMSVCFLSISRARSVEGLSKERPQPNIFNFYIIGSILGQFAVHVATLIYIAQLCDQIEPRTEVIDLEAEFKPSLLNSAVYLLQLIQQISTFAVNYQGRPFRESLSENKGMFYGIVGVTAIAFACSTEMLPELNEAMKLVPFNENFKTIMTTVMIIDFVACYVIEWVLKKLFSDLRARDIAERRPDQLERERVRKEKEAREKEEEEERKERERIEAFERRLEEKRTRLVEAAAQREQQQQQWAQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0S578</accession>
    <name>G0S578_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">pyridoxal 5'-phosphate synthase</fullName>
            <ecNumber evidence="4">1.4.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0032540</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="4"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693693.1">
        <property type="nucleotide sequence ID" value="XM_006693630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S578"/>
    <dbReference type="STRING" id="759272.G0S578"/>
    <dbReference type="GeneID" id="18257292"/>
    <dbReference type="KEGG" id="cthr:CTHT_0032540"/>
    <dbReference type="eggNOG" id="KOG2586">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032263_2_0_1"/>
    <dbReference type="OMA" id="AYFRTRP"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019740">
        <property type="entry name" value="Pyridox_Oxase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00558">
        <property type="entry name" value="pdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004231">
        <property type="entry name" value="PRK05679.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851:SF0">
        <property type="entry name" value="PYRIDOXINE-5'-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PYRIDOXINE-5-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01064">
        <property type="entry name" value="PYRIDOX_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="8">
        <location>
            <begin position="74"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridoxine 5'-phosphate oxidase dimerisation C-terminal" evidence="9">
        <location>
            <begin position="223"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS21397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="268" mass="30155" checksum="7978A1FCC7AB0656" modified="2011-10-19" version="1">MALHPSQNVAKLIFAPTGTPKPFEPSGATGQAAQFLKAELIGGLRRAHLNPDDPIAQFHDWFRQASQPESGVGHPETCTFATAQLPSGRVSARMVYLKELDTKGFVIYSNWGTSGKARDLFGSADGSSVGNPWASLVFWWEPLERQVRVEGKVERLTAEESQAYFSTRVRGSQIGAWSSRQSVVLKPNPEILGDDGRAQLEAWVRETEQRFEGTDDIPVPDFWGGVRIVPERFEFWQGRQNRLHDRFVYDRVRGEDGVDRWTLERLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0S588</accession>
    <name>G0S588_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Putative transcription factor kapC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0032650</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Putative transcription factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bZIP family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693703.1">
        <property type="nucleotide sequence ID" value="XM_006693640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S588"/>
    <dbReference type="STRING" id="759272.G0S588"/>
    <dbReference type="GeneID" id="18257303"/>
    <dbReference type="KEGG" id="cthr:CTHT_0032650"/>
    <dbReference type="eggNOG" id="ENOG502SC5V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_541844_0_0_1"/>
    <dbReference type="OMA" id="SEMEMGF"/>
    <dbReference type="OrthoDB" id="2593073at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="11">
        <location>
            <begin position="174"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="121"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="235"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="291"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="358"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="478"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="187"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
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        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
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        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
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        <location>
            <begin position="246"/>
            <end position="259"/>
        </location>
    </feature>
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        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
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        <location>
            <begin position="307"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="483"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS21407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="503" mass="53509" checksum="49C56BEFC191228E" modified="2011-10-19" version="1">MSSNALTTPTTRRGTPDAKLLRELLTAVQAAEPSAQEQPGVSQPETEANQPAYQTQAYAGHPQPGPEAPGASRSPSGAAAQPLPHGYAHPQLPQTDAQIHPELRSPHDPAAVVAHTQYAPTPNMMPAGVPPPDQQVAMQGTPAPVAQPAPAPEAAAAAAPADGRKPKRELSQSKRAAQNRAAQRAFRQRKEMYIKKLEQQCKDYEQMEVAFKALQAENCALRDYALQLQNRLLELTGEHPPPPPGLNLSHPPRIDAPQQPGVPQPAGAQPPAPVNNLDAAAAAAAQAVSGLNNTAGPNHRPDQHHLAPAAGSRPAPGAQDPYAAARAAAAAAAAAAADDDARTAAEITRQLQADVATASAGSDGLPAAPMSSKNGSKPRRRTLKNLKPSGEKDSVQQPSSDAHTPQRPRRFTPAVLQSSQDSGSTIAAYNLDERQQHEGLLRIPPWEVSEEMISQNQARGDGARLYWGDKIDWDPDCFAEGRKMKKKKKRKKRKRKRGSDAYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5A4</accession>
    <name>G0S5A4_CHATD</name>
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        <recommendedName>
            <fullName evidence="4">HTH CENPB-type domain-containing protein</fullName>
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        <name evidence="5" type="ORF">CTHT_0024110</name>
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        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Sordariomycetes</taxon>
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            <taxon>Chaetomiaceae</taxon>
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        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
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        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
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        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF70">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CENP-B_N"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
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    </dbReference>
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        <property type="entry name" value="HTH_CENPB"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
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            <begin position="198"/>
            <end position="273"/>
        </location>
    </feature>
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        <location>
            <begin position="100"/>
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        </location>
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            <begin position="537"/>
            <end position="565"/>
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            <begin position="105"/>
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            <begin position="343"/>
            <end position="361"/>
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            <begin position="469"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="565" mass="60603" checksum="08D75475DB9E5E75" modified="2011-10-19" version="1">MQNPIVTSGVDQESHLTPDPAAPFVTDGWVDMNSFHQPTTMPEYAGFSFLHISHGLPSESLARLAVAPAAPPPAQPLHAPQPHPQLQMLMMNPAPTAWPSMLTNPAPPTYAPPPPPQAAPPVPIPPIPAPIKKSGTGSQPRKTLTDEDRRRMCQYAEENPGAKQTDIGARFGVERSTVSKVLRNKDKYLNQDDRSSSPIRRPLKGKGVDIEKALSNWVTKAQKSGHTVTRDELKEKLRMFAATQSVSDSVLKSSYNSAWLDKFMLRHNINPGRLLRRASETNITDSMRSSGSPLLPASQPSSAISPTSPSGQLSPPSLPATKNEEDKDGMNNIVDFTNGLYKNPNTQSTTSLSSAFTDTSTPPFPGGAISPTNSFNFSPDPNTGAFQVPVPGPGFQRPRSQTFPTLDMEYLNQTQSADANAKFPPSATPSSALDSAGTEPPVPSYTFEPTVSSPRLRHSSSNSSIAGRGTTTPITNSAVTSSPASPTQEDAFRAADTLLSYLRSSNGLADQTELKIVMRLTEKLRIHQSKPSISVGIGGLSRIPEGDNEMASAPPVMKMETTMSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5C0</accession>
    <name>G0S5C0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0024270</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692889.1">
        <property type="nucleotide sequence ID" value="XM_006692826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5C0"/>
    <dbReference type="STRING" id="759272.G0S5C0"/>
    <dbReference type="GeneID" id="18256465"/>
    <dbReference type="KEGG" id="cthr:CTHT_0024270"/>
    <dbReference type="eggNOG" id="ENOG502RZ7A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043194_1_1_1"/>
    <dbReference type="OMA" id="MWEKTHQ"/>
    <dbReference type="OrthoDB" id="412109at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038753">
        <property type="entry name" value="NFKBIL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263">
        <property type="entry name" value="I-KAPPA-B-LIKE PROTEIN IKBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263:SF1">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="264"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="66"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS20593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="51721" checksum="A784BF18FDC7B8A0" modified="2011-10-19" version="1">MDETPRSPMRRRILAAMLPPEIEGSEPWRKRRKCSTRSRSRDRSRSRSSSRSPSIGPQPPPTSGTRNDDSRRAEEGRREEEKREERERGHRENDPLAPRPTRFRFKDKSKSSSKSSRSRGGSVDDEREGRCRHQSRHRRHGSSHRSRSRSRSPSNKDKDKDTHRSRNQKHHHRHSHRHKHRTPSPQPPPEDPYADRPLTPNTAFRESLMDALADDEGAAYWEAVYGQPIHIYNRHLGPLEQMTDEEYAAYVRQKMWEKTREGLLEERERRLREKKERERMAMEERERRKKVQMEMEIALRRGEERKRKRRWEGYCQKWKEWEKEPTVEGVPWPEGVVPLEEEGEDDVAAEEREEVVKRDIVKSFFVDGIRLALGEGETDDKVIAARLKEERVRWHPDKVQQRLGGKVEERIMKRVTAIFQVVDSLWNEVRKKGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5C5</accession>
    <name>G0S5C5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">L-dopachrome isomerase</fullName>
            <ecNumber evidence="9">5.3.2.1</ecNumber>
            <ecNumber evidence="8">5.3.3.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">L-dopachrome tautomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phenylpyruvate tautomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0024320</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-phenylpyruvate = enol-phenylpyruvate</text>
            <dbReference type="Rhea" id="RHEA:17097"/>
            <dbReference type="ChEBI" id="CHEBI:16815"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="EC" id="5.3.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-dopachrome = 5,6-dihydroxyindole-2-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13041"/>
            <dbReference type="ChEBI" id="CHEBI:16875"/>
            <dbReference type="ChEBI" id="CHEBI:57509"/>
            <dbReference type="EC" id="5.3.3.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.2.1" evidence="9"/>
    <dbReference type="EC" id="5.3.3.12" evidence="8"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692894.1">
        <property type="nucleotide sequence ID" value="XM_006692831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5C5"/>
    <dbReference type="STRING" id="759272.G0S5C5"/>
    <dbReference type="GeneID" id="18256470"/>
    <dbReference type="KEGG" id="cthr:CTHT_0024320"/>
    <dbReference type="eggNOG" id="ENOG502S2ZV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1277499_0_0_1"/>
    <dbReference type="OrthoDB" id="255819at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004167">
        <property type="term" value="F:dopachrome isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050178">
        <property type="term" value="F:phenylpyruvate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001398">
        <property type="entry name" value="Macrophage_inhib_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954">
        <property type="entry name" value="D-DOPACHROME DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954:SF6">
        <property type="entry name" value="MACROPHAGE MIGRATION INHIBITORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="Tautomerase/MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS20598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="216" mass="24125" checksum="50965DD21029C9C9" modified="2011-10-19" version="1">MKAIRAIRSRRLPGDVARARESSPKRRESQDKGEEQATDASGVLTGVFTSPSLSRREDEVEKEKQVQRLHALAKDRVHGDALVLAEVKTNVIISDEFTFITELSYHLSTRYRRPVSSIAVTVHHGVCMFFAGSFDPAYILTISAPREVLYCSNNLVEHRRNATQVMRHMEESLGVGCARGLVRLRTGVDEKAAGTSSEESDTRGHYSSIKCRRGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5C8</accession>
    <name>G0S5C8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NADH-ubiquinone oxidoreductase B15 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0024350</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="4 5 6" key="2">
        <citation type="journal article" date="2022" name="Sci. Adv." volume="8" first="eadc9952" last="eadc9952">
            <title>Conformational changes in mitochondrial complex I of the thermophilic eukaryote &lt;i&gt;Chaetomium thermophilum&lt;/i&gt;.</title>
            <authorList>
                <person name="Laube E."/>
                <person name="Meier-Credo J."/>
                <person name="Langer J.D."/>
                <person name="Kuhlbrandt W."/>
            </authorList>
            <dbReference type="PubMed" id="36427319"/>
            <dbReference type="DOI" id="10.1126/sciadv.adc9952"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.44 ANGSTROMS)</scope>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692897.1">
        <property type="nucleotide sequence ID" value="XM_006692834.1"/>
    </dbReference>
    <dbReference type="PDB" id="7ZM7">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.77 A"/>
        <property type="chains" value="j=1-75"/>
    </dbReference>
    <dbReference type="PDB" id="7ZM8">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.76 A"/>
        <property type="chains" value="j=1-75"/>
    </dbReference>
    <dbReference type="PDB" id="7ZMB">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.75 A"/>
        <property type="chains" value="j=1-75"/>
    </dbReference>
    <dbReference type="PDB" id="7ZME">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.83 A"/>
        <property type="chains" value="j=1-75"/>
    </dbReference>
    <dbReference type="PDB" id="7ZMG">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.44 A"/>
        <property type="chains" value="j=1-75"/>
    </dbReference>
    <dbReference type="PDB" id="7ZMH">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.47 A"/>
        <property type="chains" value="j=1-75"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5C8"/>
    <dbReference type="EMDB" id="EMD-14791"/>
    <dbReference type="EMDB" id="EMD-14792"/>
    <dbReference type="EMDB" id="EMD-14794"/>
    <dbReference type="EMDB" id="EMD-14796"/>
    <dbReference type="EMDB" id="EMD-14797"/>
    <dbReference type="EMDB" id="EMD-14798"/>
    <dbReference type="SMR" id="G0S5C8"/>
    <dbReference type="STRING" id="759272.G0S5C8"/>
    <dbReference type="GeneID" id="18256473"/>
    <dbReference type="KEGG" id="cthr:CTHT_0024350"/>
    <dbReference type="eggNOG" id="ENOG502S8RT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_183941_2_0_1"/>
    <dbReference type="OMA" id="RYKYWRW"/>
    <dbReference type="OrthoDB" id="15108at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39476:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39476">
        <property type="entry name" value="NADH:UBIQUINONE OXIDOREDUCTASE 6.6KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4 5 6" id="KW-0002">3D-structure</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="7ZM7"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="7ZM8"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="7ZMB"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="75" mass="8746" checksum="8B47F4CB6CD3910F" modified="2011-10-19" version="1">MAGLQHYKIAMDPALVRLGSMISNRYKYFRWTKRTALVSFMYVVVVPSTIGYLAYKTDGLWDLRAKRRGDLISER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5R5</accession>
    <name>G0S5R5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">NADPH--cytochrome P450 reductase</fullName>
            <shortName evidence="20">CPR</shortName>
            <shortName evidence="20">P450R</shortName>
            <ecNumber evidence="20">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">cprA</name>
        <name evidence="23" type="ORF">CTHT_0033350</name>
    </gene>
    <organism evidence="24">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 20">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="20">Binds 1 FAD per monomer.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="20">Binds 1 FMN per monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="20">Endoplasmic reticulum membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Mitochondrion outer membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Cell membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the NADPH--cytochrome P450 reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="20"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693773.1">
        <property type="nucleotide sequence ID" value="XM_006693710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5R5"/>
    <dbReference type="STRING" id="759272.G0S5R5"/>
    <dbReference type="GeneID" id="18257373"/>
    <dbReference type="KEGG" id="cthr:CTHT_0033350"/>
    <dbReference type="eggNOG" id="KOG1158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_17_3_1"/>
    <dbReference type="OMA" id="QKRYQRD"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
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    <sequence length="806" mass="89983" checksum="4EDA52F993EC5017" modified="2011-10-19" version="1">MRWYECAVRAASSGERRSRAPSNPYCFNRRSDRTYSRLTFPAADSIDESSVTGIPSVGVLFTVVYKADARTGPCLPLRPWWRVTSLSHLGRSQAQSPNASVPTSNVPPLVAIVTMAELDALDVIVLAVILLGTVAYLTKGKYWGVKKDPYTTPLPGSAAAKAGRTRNIVEKLEESGKNCIIFYGSQTGTAEDYASRLAKEGKSRFGLETMVADLEDYDYDNLDAVPSDKIVMFVLATYGEGEPTDNAVEFYEFITSENPDFSSGETEKPLKNLHYVAFGLGNNTYEHYNAMVRNVDKALQRLGASRIGEAGEGDDGAGTMEEDFLAWKEPMWEAVAKKMGLQEREAIYEPIFGIVERDDLTRDSPEVYLGEPNKMHLDGEPKGPFNAHNPYTAPIQKSYELFNSKDRNCLHMEIDISGSNLTYQTGDHIAIWPTNAGQEVDRFLNIFDLADKRHTVISVKPLEPTAKVPFPTPTTYDAIVRYHMEICAPVSRQFVATLAAFAPDDESRAELTKLGNDKDYFHSKVTTQYLNIARLLEIVSKGKKWSNVPFSALIEGITKLQPRYYSISSSSLEHPKLVSITAVVESQALPGREDPFKGVATNYLLALKEKQNGDASPSPYGLTYEITGPRNKYDGIHVPVHIRHSNFKLPSDPTRPIIMIGPGTGVAPFRGFIRERKKLAENGQTVGKSILFFGCRRSTEDFMYQKEWEEVKQVLGDKFELVTAFSREGSKKVYVQHRLKERSKEINALLDQKAFFYVCGDAANMAREVNATLAQILADERGISKSKAEEIVKQMRASNQYQEDVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6E8</accession>
    <name>G0S6E8_CHATD</name>
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        <recommendedName>
            <fullName evidence="6">SH3 domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="4" type="ORF">CTHT_0034660</name>
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    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
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            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_006693836.1"/>
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    <dbReference type="eggNOG" id="ENOG502QTHB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022614_0_0_1"/>
    <dbReference type="OMA" id="CADTCAL"/>
    <dbReference type="OrthoDB" id="2163411at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3-like_dom_sf"/>
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        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409336" description="SH3 domain-containing protein" evidence="3">
        <location>
            <begin position="33"/>
            <end position="520"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="354"/>
            <end position="364"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="369"/>
            <end position="384"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="460"/>
            <end position="471"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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        <source>
            <dbReference type="EMBL" id="EGS21603.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
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        <source>
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        </source>
    </evidence>
    <sequence length="520" mass="54776" checksum="123CA396935F6187" modified="2011-10-19" version="1">MTSTAKPRRRSSRLGAKGALLALLSAPPTAMAACLSLQGSKACAAFQSSSVSTNDSHLVGLFYASNVQRFDELLTTYVQTEYAQFAQAEAYVLADPGLCPNPGGNAQSQIRADFVTCSLPDNSLSSRNCIPGIANEPENCGYGNSTIGLCSYCAKGGINSTDTCCYQSNAEARCKDVVLPSITPITLPTVTATTTAIPEGSEGGLSGGVIAGIVIGSIVAAALLAGLAFFIFYRRKRSGSQQGSVFNQPSPARHGPPPPPVKQTSSGPVSFEILPGGRVARMSALEGHSSDGPSRHTVRDIPSSLPGTAGTYRGSRRRGDDRSSSDGFGSSPASERGISAGILRPPPTALRRNGSLSSSSVLVGDDGHSPSSAGMSSPQGIASQQSEQLPFFKDYYSQDDIHPGDRVAVLWAYQPRAPDEFLLERGDMLKVIGIWDDGWATGVMLDERAEQWEARRQAQRDSGVSNTSGRLNDSPRPITGEIKAFPLVCVCLPQHWRRTIEGDGSVETGSSGPPYTTTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6G5</accession>
    <name>G0S6G5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA (guanine(10)-N(2))-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.214</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0034840</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM11 methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.214" evidence="9"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693916.1">
        <property type="nucleotide sequence ID" value="XM_006693853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6G5"/>
    <dbReference type="STRING" id="759272.G0S6G5"/>
    <dbReference type="GeneID" id="18257522"/>
    <dbReference type="KEGG" id="cthr:CTHT_0034840"/>
    <dbReference type="eggNOG" id="KOG2671">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029646_3_0_1"/>
    <dbReference type="OMA" id="AFNKWSR"/>
    <dbReference type="OrthoDB" id="296065at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160102">
        <property type="term" value="F:tRNA (guanine(10)-N2)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000672">
        <property type="entry name" value="RNA methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RlmKL-like_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016691">
        <property type="entry name" value="TRMT11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059073">
        <property type="entry name" value="TRMT11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370">
        <property type="entry name" value="RNA METHYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370:SF3">
        <property type="entry name" value="TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25904">
        <property type="entry name" value="Tmrp11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017259">
        <property type="entry name" value="tRNA_mtfrase_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00507">
        <property type="entry name" value="N12N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51627">
        <property type="entry name" value="SAM_MT_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 10" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA (guanine(10)-N(2))-methyltransferase TRMT11 N-terminal" evidence="12">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA large subunit methyltransferase K/L-like methyltransferase" evidence="11">
        <location>
            <begin position="181"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS21620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="449" mass="51276" checksum="22EE483A0B36B230" modified="2011-10-19" version="1">MDFLIRFSQSHETFRLPEIQALAVIERVDLKIISYSLESPFCIVQLPSEDAARRLVRRSILVMSIHELWGHGPDLNTVHKAVKTSTQHLWSLYKTCSFKFTIDSYQGSRSAEDKVRIINSFAYLGFEGPIRMRGADEEFVLHEDWPYNATLLGIPDPKHYYFGRRLANGARDLPKKLDLKKRRYISTTSMDAELALVTANMALAAPGKIMYDPFVGTGSFPIACAQFGALTFGSDIDGRSIRGDEKKRTLKANFEQYGLLAGLGGMFTADLTNSPIRRTELRYDGDGVTGRLFDGIVCDPPYGVREGLRVLGVRDPEKSPWVEKKGREMYKNPDFIPPKKPYSFFNMLDDILHFAAQTLVDNGRLSFWMPTANDENQEIPVPTHPYLEVVSVCTQTFNKWSRRLITYRRIPDREVDPEAMKARQRRIEVGKTADELNPFRKAYFTKFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6I8</accession>
    <name>G0S6I8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Myotubularin phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0026370</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693095.1">
        <property type="nucleotide sequence ID" value="XM_006693032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6I8"/>
    <dbReference type="STRING" id="759272.G0S6I8"/>
    <dbReference type="GeneID" id="18256675"/>
    <dbReference type="KEGG" id="cthr:CTHT_0026370"/>
    <dbReference type="eggNOG" id="KOG1089">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001839_5_1_1"/>
    <dbReference type="OMA" id="RTMEGFM"/>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF128">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3,5-BISPHOSPHATE 3-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="5">
        <location>
            <begin position="139"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="515"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="697"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="784"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="697"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="784"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="804"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="2">
        <location>
            <position position="419"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="355"/>
            <end position="356"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="419"/>
            <end position="425"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS20799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="820" mass="91930" checksum="59899BDC8BDF14B1" modified="2011-10-19" version="1">MSAPQHRHVFRDVQALRGGVPEAGDLALTDFHMIFKFPAESRIAADSRLKKQVKQVWFAYPLIAHCTLRPTPPSSGIPSSIRLRFRDFTFVTFNFPDDKQARDAFEFVRARTCRLGSIEKLLAFHYTPPPGSPEHKINGWDIYDARAEFRRQGISEKSADIGWRISTINKDYTFSPTYPALLVVPSKISDNTLKYAANFRSRARIPVLTYLHPVNNCTITRSSQPFVGLRMKRSIQDERLVAACFSSNEHLDSTQSTNADRSPASSHVDLSSDYAEDDLSLSETERMRMEEELAGVNAFYDEKTGKRLIYGAQQHNLIVDARPAINSYAMQAIGMGSENMDYYKFAKKSFLNIDNIHVMRDSLEKVINAIKDADVSPFPPNKELLAKSKWLKHITGILDGAAVIARQVGIQHSHVLIHCSDGWDRTSQLSALAQLMLDPYYRTIEGFIVLVEKDWLSFGHMFQLRSGHLSHESWFTVDNDALAGTAIRPGESDGRTDALGSVMAGAKRFWNKNIGGEKDKDTSTDADDTSALDDAKAGTAPVSEDQATKPRDVSPIFHQFLDATYQLLRQHPTRFEFNERFLRRLYYHVYSCQYGTFLCNNERQRREAKLRERTRSVWSYFLARRQEFTNDKYDPVVDDHVKERERIIFPKLDDIRWWYQLFNRTDDEMNGDINASIATQERVAAYQATLSEPGILSADSTSFSSPSEPGSRSSASPARRSPQPQQAAGLSQGKSMLASRESIHEALTPETRTSSALNRSASTGGIPATLGALQDKLSSLAIGKGVFGSSTGSSSSGKLSGSSDKPDDEGSKEQEMKEMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6K6</accession>
    <name>G0S6K6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ran-specific GTPase-activating protein 1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0026550</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693113.1">
        <property type="nucleotide sequence ID" value="XM_006693050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6K6"/>
    <dbReference type="STRING" id="759272.G0S6K6"/>
    <dbReference type="GeneID" id="18256693"/>
    <dbReference type="KEGG" id="cthr:CTHT_0026550"/>
    <dbReference type="eggNOG" id="KOG0864">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067861_0_1_1"/>
    <dbReference type="OMA" id="NFKDSFM"/>
    <dbReference type="OrthoDB" id="2357150at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13179">
        <property type="entry name" value="RanBD_RanBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000254">
        <property type="entry name" value="Ran-specific GTPase-activating protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045256">
        <property type="entry name" value="RanBP1_RanBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF87">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE RANBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="2">
        <location>
            <begin position="78"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS20817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="240" mass="27050" checksum="49099EFF1BE2C9E5" modified="2011-10-19" version="1">MSSESDNKPVDEVKSVTSSSVFSMFGGGAKKEKKEEEDRGDISGSAKAQREAAAAAKESAKEGAGDEDDQPPESEDVHFEPVIRLTEKVEIKTHEEQEEQVFKMRAKLFRYHPESKEWKERGTGDVRLLKHVETGKVRLVMRRDKTLKVCANHYILPEMTLSPNVGSDRSWVWTAAADMSDEKPEAVTLAIRFANSDNANEFKEAFVKAQKENEAIMRKAKGEDAKEEKEEKKEEEKESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6T3</accession>
    <name>G0S6T3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">DNA replication complex GINS protein PSF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0035510</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GINS2/PSF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693981.1">
        <property type="nucleotide sequence ID" value="XM_006693918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6T3"/>
    <dbReference type="STRING" id="759272.G0S6T3"/>
    <dbReference type="GeneID" id="18257589"/>
    <dbReference type="KEGG" id="cthr:CTHT_0035510"/>
    <dbReference type="eggNOG" id="KOG4071">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078274_0_0_1"/>
    <dbReference type="OMA" id="DSLNCMY"/>
    <dbReference type="OrthoDB" id="1938138at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11712">
        <property type="entry name" value="GINS_A_psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21694">
        <property type="entry name" value="GINS_B_Psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1020:FF:000001">
        <property type="entry name" value="DNA replication complex GINS protein PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.5.50:FF:000001">
        <property type="entry name" value="DNA replication complex GINS protein PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007257">
        <property type="entry name" value="GINS_Psf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056784">
        <property type="entry name" value="PSF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25005">
        <property type="entry name" value="PSF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028998">
        <property type="entry name" value="GINS_Psf2_subgr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein PSF2 N-terminal" evidence="11">
        <location>
            <begin position="10"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="GINS subunit" evidence="10">
        <location>
            <begin position="73"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="238"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR028998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS21685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="253" mass="27424" checksum="1983BC64B76DE2D5" modified="2011-10-19" version="1">MALPLPPGLTPAEVSFLAEMELVTVIPRQRLDSIELLSGKTPPLRPPHRADLPLWLALLLKKQRRANILPPPWLHPDSLREIIHQETTVDPQAFSEPPPARHPRADPARPGRTLPIHQDDDGFILSPPFRPGSCTADAPVGFLPYHWLEVAEMLLAHAADDIGAPAGEVRGLLRDLVEVRAAKLRNSTSVLEGFGGGLMSLRGVGAMELAESRGFVLSVVDGVRKIGASTEAARREAEEEEEGADASDEDMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6Y6</accession>
    <name>G0S6Y6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CTHT_0027330</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693190.1">
        <property type="nucleotide sequence ID" value="XM_006693127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6Y6"/>
    <dbReference type="GeneID" id="18256771"/>
    <dbReference type="KEGG" id="cthr:CTHT_0027330"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010365_3_1_1"/>
    <dbReference type="OMA" id="GKNGWVF"/>
    <dbReference type="OrthoDB" id="4494341at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000023">
        <property type="entry name" value="Putative ferric-chelate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF24">
        <property type="entry name" value="REDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="15">
        <location>
            <begin position="337"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGS20894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="628" mass="69414" checksum="09ABB453D517E8D2" modified="2011-10-19" version="1">MSSQAITGAAPIATGAAGGQGQGSAAGGQWGGAGGAAGGASGGAQGQQEGGYGGPGGATNSLDPDVVNELLAHYLLIVLGSISIALLTWRLTTMIIRYVRHVACLYNETQRYFARPNEEWAWFKKNILYAPILSKRHNREFQLSSALNMGTLPTRMQLVFLLGYFATNVAFCVMTIDFSGPLRQVAALVRNRTGYLATVNMIPLFLMAGRNNPLIQLLGMSFDTFNLLHRWFGRIVALEALTHTLAWMVSNASTNGWPSAFSTVTKVPFLLWGFVSTCAMVFICIQAASIFRHAYYETFKILHIALAILSVIGLWWHLDMKQLPQLRYLYPVVILWACDRAARFLRVAYHNFGAGGTKALVEALPGGACRVTVTMARPWTFRPGQHAYLYMPSIGFWQSHPFTVAWSEENDHADADRLPISRRDIHGQKKTTISFIIRGRTGFTGALYSRACARPDGKLVTRCLVEGPYRGSHRFGSYGTVMLFAGGVGVTQVVPHVRELVAGYANGTVATRKVIMVWSIQSPEHLEWIRPWMTQVLAMERRREVLRILLFVSRPRSTKEIQSPSNTVQMFPGRPNIDTLIGMEMESQVGTMAVSVCGPGSLSDEVRRAVRNRMYQGSVEFIEEAFSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0S761</accession>
    <name>G0S761_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">H/ACA ribonucleoprotein complex subunit NOP10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Nucleolar protein 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Nucleolar protein family A member 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">snoRNP protein NOP10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0027550</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NOP10 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693212.1">
        <property type="nucleotide sequence ID" value="XM_006693149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S761"/>
    <dbReference type="STRING" id="759272.G0S761"/>
    <dbReference type="GeneID" id="18256793"/>
    <dbReference type="KEGG" id="cthr:CTHT_0027550"/>
    <dbReference type="eggNOG" id="KOG3503">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2158091_0_0_1"/>
    <dbReference type="OrthoDB" id="13807at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904874">
        <property type="term" value="P:positive regulation of telomerase RNA localization to Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007264">
        <property type="entry name" value="H/ACA_rnp_Nop10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036756">
        <property type="entry name" value="H/ACA_rnp_Nop10_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04135">
        <property type="entry name" value="Nop10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144210">
        <property type="entry name" value="Nop10-like SnoRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS20916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="111" mass="12235" checksum="9307FC33CCB6C243" modified="2011-10-19" version="1">MHLMFVPDGQGGRIYTLKKVLNGQVTKSAHPARFSPDDKWSRHRLMMHKRYAPLFALHYAQENEKARAAVAKAQAAAEAAAKTAIEMELATQKELAEQTSGKNKALTNSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0S787</accession>
    <name>G0S787_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0027810</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="5">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GcvH family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693238.1">
        <property type="nucleotide sequence ID" value="XM_006693175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S787"/>
    <dbReference type="STRING" id="759272.G0S787"/>
    <dbReference type="GeneID" id="18256819"/>
    <dbReference type="KEGG" id="cthr:CTHT_0027810"/>
    <dbReference type="eggNOG" id="KOG3373">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097408_1_2_1"/>
    <dbReference type="OMA" id="KEHEWIR"/>
    <dbReference type="OrthoDB" id="10264154at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002270">
        <property type="entry name" value="PRK01202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715:SF3">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="59"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="4">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS20942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="173" mass="18599" checksum="9B632758F44A3541" modified="2011-10-19" version="1">MASIARSLRLARLSAVSATIRAPAYRAVFIRPFSVTASNAIRKYTKEHEWIDISADKKTGVVGISEYAAKTLGDIVYVELPEEGLEVQAGDAIGAVESVKSAADIYSPVACKITQVNLLLEEKPGTVNQVPEDDSHGGGWIAKVQLTEQGLKDFEALMDADAYAEFTAAESDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0S797</accession>
    <name>G0S797_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0036080</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694037.1">
        <property type="nucleotide sequence ID" value="XM_006693974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S797"/>
    <dbReference type="GeneID" id="18257646"/>
    <dbReference type="KEGG" id="cthr:CTHT_0036080"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_25_1_1"/>
    <dbReference type="OMA" id="FIVYEWR"/>
    <dbReference type="OrthoDB" id="4161376at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF195">
        <property type="entry name" value="PEP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="39"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS21741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="545" mass="58186" checksum="210EB0FC9F24D04F" modified="2011-10-19" version="1">MTSSGETEKPPKPTDSSSTSGSNSRSDDEPQPHLHARTFLAVVAVNLIYVAQLFALVGAGSQGQIIAGHFGRTDQVTWLTAPITILTVVLGPIVSQAADYWGRKWFLVVLSAFGAIGCLIVSRATSMSMIIAGFTVVGLAFGAQPLLHAVPSEVLPRRLRAWAQGSVMIANGIGLVAGLIVGGALNRNHNPNGWRNHYYISTAIFAAAAVICSFAYRPLPRPLETTLTFKEKISRLDWIGYILLAISLVLFCMGLSWSQNPYPWSDPHTSATFAIGLFFGLILVAYETFVKKDGMFHHGLFQINRNFAISLVCIACEGIAFFAANIYFAFQVNVLITKKVRWVTVLAFLIFVAFFVAMATTTKSTNDPVWGYAVLMGWALGMTLVTLVAAGQLAVTGELISIASGLMISVRSLGGTIGIAIYNAIFIEAMKHLGTNVAKAAIQAGLPQASVPDFIGALTSQNETALGLVEGVNPEIIGAGAGALLDTYAKGFRNVWSAAAAFVALGAILAVFLLDSTKDFNNHIDAPVEKEEDLYSASENQSTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7K3</accession>
    <name>G0S7K3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative suppressor of profilin protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0036620</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694090.1">
        <property type="nucleotide sequence ID" value="XM_006694027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7K3"/>
    <dbReference type="STRING" id="759272.G0S7K3"/>
    <dbReference type="GeneID" id="18257700"/>
    <dbReference type="KEGG" id="cthr:CTHT_0036620"/>
    <dbReference type="eggNOG" id="ENOG502QQAW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011037_0_0_1"/>
    <dbReference type="OMA" id="FQTHEVD"/>
    <dbReference type="OrthoDB" id="331602at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032185">
        <property type="term" value="P:septin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09264">
        <property type="entry name" value="AP_Syp1_MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07650">
        <property type="entry name" value="F-BAR_Syp1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000102">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018808">
        <property type="entry name" value="Muniscin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049609">
        <property type="entry name" value="Syp1-like_MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF54">
        <property type="entry name" value="SUPPRESSOR OF YEAST PROFILIN DELETION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10291">
        <property type="entry name" value="muHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MHD" evidence="4">
        <location>
            <begin position="584"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="239"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="519"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="272"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="322"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="532"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="547"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS21794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="867" mass="95091" checksum="93565A0BD5787BE2" modified="2011-10-19" version="1">MATVDDLSRTEYPAMLAHLQPSQAVQVFSDRVKRITKTNQEIADWLQERRKVEEQYVAGLRKLLVFKVPNPSSELGVFQTPWDKILQSIESIAAAHQVFAQRIHEDVEQPLRQFQNKKEMQNIHTIASNLQTMARELEDATEKSDKLNKKGGKASAQKVDQAAARLETATQQWESQAPFIFETLQALDEQRINHLRDVLTQYETHEVDQAGRTQSAAEEVLNIMLEVNTSEEIRNFAQRTTAGKPKVERRTARQPGSAAPSPVAASVTGDDVSEHSGHREHQPESKLRSRIGTMLGRRRQSVHAGFGQLSPQKGLGSFSHRLGSSHSHTLSPRASSHNLAESHNRLSSVVERPTTEQPAAGDTTDKDQQRPHEGTNGVTTTGDLSRDHQPARPNLLNGTAEDIFDTPPPVPPLPQTIKEEPKKDAEGFTIPPLMNDPISQAQREAAAEAGETEQLFKLNIQNEPIAEEDQEAKQQAMSNVANALTSMAVPARRTGTVRGRREVRNTMYMPVAPIADITAENPFPPSPSLPASTSVPKVTPTTPLTSEPSHASDTQSIRSGTSVGASSSALARIRHPDLHGPNQAPGLHSSIIETVSAVFKDGEPQTVRVTGEIALAYVPDPEKPFTDHETIRLNNFSVLESIGPNRVFVANAPSPDEFTIDVSHLSMTTPAFTYRVHAESDTALAPHCPIALHPVWKPQGDKLGLLLQYRLNPSFSHATRSPVTLSNAVFIATYEGARASGVQTKPSGTHLKDKHIVYWRLGDVTLTEDWAKIICRVIGDQNAEPQPGHVEVRWEWVPPQPEGVGSGISVSRLLAEGPAAKGKEKEEEDPFADEAVISSAPASPHIERTWADVPLVKKVISGKYESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7W8</accession>
    <name>G0S7W8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Palmitoyl-protein thioesterase 1</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Palmitoyl-protein hydrolase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0037260</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palmitoyl-protein thioesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694151.1">
        <property type="nucleotide sequence ID" value="XM_006694088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7W8"/>
    <dbReference type="STRING" id="759272.G0S7W8"/>
    <dbReference type="GeneID" id="18257764"/>
    <dbReference type="KEGG" id="cthr:CTHT_0037260"/>
    <dbReference type="eggNOG" id="KOG2541">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050129_0_1_1"/>
    <dbReference type="OMA" id="KFVMVMF"/>
    <dbReference type="OrthoDB" id="10263094at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000107">
        <property type="entry name" value="Palmitoyl-protein thioesterase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002472">
        <property type="entry name" value="Palm_thioest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF8">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02089">
        <property type="entry name" value="Palm_thioest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00414">
        <property type="entry name" value="PPTHIESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408895" description="Palmitoyl-protein thioesterase 1" evidence="9">
        <location>
            <begin position="23"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS21855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="329" mass="36945" checksum="717C4E8A9DC51D02" modified="2011-10-19" version="1">MAIRNHLTALVIAGSLLSAALTKPLDVRFSDDTDDTPLPVVIWHGLGDAYDTDGMRRVAELVEEVNPGTFVYAIRMDESGARDRYASFIGNLTNHIGKACADIAAHPILSTAPAIDAIGFSQGGQFLRAYVERCNNPPVRSLVTFGSQHNGISAFRDCAPNDWVCRFAMAILTGDAWSPTVQSRLVPAQYYRNPNEFNQYLEHSNFLADINNERVVKNEQYKKNIAQLESFVMYMFEDDKTVIPKESSWFHDVNGTEVTPLRQRRLYTEDWLGLRELDKKGGLYFRTAPGEHMELSEELLVEAFGDFFGPLNRHAGRSDPRPRLQAGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0S816</accession>
    <name>G0S816_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0029030</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693359.1">
        <property type="nucleotide sequence ID" value="XM_006693296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S816"/>
    <dbReference type="GeneID" id="18256941"/>
    <dbReference type="KEGG" id="cthr:CTHT_0029030"/>
    <dbReference type="eggNOG" id="ENOG502QSKG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_0_0_1"/>
    <dbReference type="OMA" id="IHMRIMT"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS21063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="40246" checksum="5D8D54A72C92707B" modified="2011-10-19" version="1">MAESSDSKTDKPVTQTPGLLPSSHWASLKDETANREYDTNDSSSEHTSFLSSTTSVTSTLRRFRSLHGRTYHSEIGIAQSWTPNDLKHIGALEFMHASFLVAMDEKLFLAPVDTSKLKRVLDVGTGAGHWAIDMGDLYPNAEIIGLDITPMQPTWVPPNVSFQIDDANQPWTFADNYFDFVHTRFLSGCIADWDKFYRDAFRCIKPGGWLEHQEVNIAWFDDSDPIPEESPLGQYGPSFREAGNRSGRTFCVVADDLQEKGMKAAGFVDIQVKDMKIPFGAWPEDERQKELGILSKAFTMADLDGWLLFTFNEILGWKPEETQVYIALLRKELNNPKRNLYYVRRVVYGRKPEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0S847</accession>
    <name>G0S847_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative pre-mRNA splicing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0029350</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC26 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693390.1">
        <property type="nucleotide sequence ID" value="XM_006693327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S847"/>
    <dbReference type="STRING" id="759272.G0S847"/>
    <dbReference type="GeneID" id="18256973"/>
    <dbReference type="KEGG" id="cthr:CTHT_0029350"/>
    <dbReference type="eggNOG" id="KOG2654">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024195_0_0_1"/>
    <dbReference type="OMA" id="GDVQRQE"/>
    <dbReference type="OrthoDB" id="6022at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070274">
        <property type="term" value="C:RES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018609">
        <property type="entry name" value="Bud13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051112">
        <property type="entry name" value="CWC26_splicing_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31809">
        <property type="entry name" value="BUD13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31809:SF0">
        <property type="entry name" value="BUD13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09736">
        <property type="entry name" value="Bud13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="17"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="239"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="287"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS21094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="354" mass="39722" checksum="1597A687E451B4DD" modified="2011-10-19" version="1">MPSDKAAYLAAHYLTAEKKSSSGTKKRKRKQTTVSTGLLIQDDDETGWSNIQQNDDENDDDLPVQVAGTSAEFRRAKKSNWKTITDNSSKPKEDDAAAAAAADAIIASAAAEAEAARKAEEAENRPVIVGEGGVELPPSADDVPLMSNGTRAGLQSAAALTAQMRAQREAEREELSRLKKQRQKDGTEEEIILRDATGRRVDAAFKRAELRKAQLEAERKEKERQRLLKGEVQIAEARAAKEREREAALMPLARGKDDKELNEELKQEGRWHDPAAEFLSPEDRGRGGNRKGKKEKSKRRPTYQGAWPPNRYMIPPGYRWDGVDRGNGHEAERFKAMNRREMRKGLEYQWQMDE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-03-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8E7</accession>
    <name>RRP8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName>25S rRNA (adenine-N(1))-methyltransferase</fullName>
            <ecNumber>2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Ribosomal RNA-processing protein 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">RPR8</name>
        <name type="ORF">CTHT_0029620</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of a conserved adenine in helix 25.1 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methyltransferase superfamily. RRP8 family.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="frameshift">
            <sequence resource="EMBL-CDS" id="EGS21121" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="2.1.1.-"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21121.1"/>
        <property type="status" value="ALT_FRAME"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693417.1">
        <property type="nucleotide sequence ID" value="XM_006693354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8E7"/>
    <dbReference type="SMR" id="G0S8E7"/>
    <dbReference type="STRING" id="759272.G0S8E7"/>
    <dbReference type="GeneID" id="18257000"/>
    <dbReference type="KEGG" id="cthr:CTHT_0029620"/>
    <dbReference type="eggNOG" id="KOG3045">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027694_3_1_1"/>
    <dbReference type="OrthoDB" id="10258825at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016433">
        <property type="term" value="F:rRNA (adenine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2150:FF:000001">
        <property type="entry name" value="Ribosomal RNA-processing protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2150">
        <property type="entry name" value="Ribosomal RNA-processing protein 8, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007823">
        <property type="entry name" value="RRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042036">
        <property type="entry name" value="RRP8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05148">
        <property type="entry name" value="Methyltransf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000435815" description="25S rRNA (adenine-N(1))-methyltransferase">
        <location>
            <begin position="1"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="536"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="539"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="550"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P38961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="586" mass="65664" checksum="F110A0EE149439A7" modified="2016-03-16" version="2">MFPVKGLSVSADKLKVEPGAIVGTAPAAPAPASAPAVSSSKPSKKRKRHGGDKDVNVDASNLVDLWEKVIEQKKEGVADGVKKHENKRLKKEHEGQGEKLSNSNNDGNQGERKNNKKKNKNKNKNQGEHGIQVAQKKGPKKVEGEEDEDDNNDDADEWEGIDEDEKHASSEKPTPKKDDKKQQQLQQQQQQKKQQKNQEKDNRNGTTSNWQQDKPQPKTATPAPKLTPLQASMREKLISARFRHLNETLYTRPSTEAFKLFEESPEMFTEYHEGFRRQVDVWPENPVDVYIKEIKERAKVRFAPKISGGAEGGKSLPPARFPLPRDQKTKVCTIADLGCGDAKLAKTLVPLKQKLRLEIHSFDLQTGGCELVTRADIANLPLPDNSVDLAIFCLALMGTNWLDFVEEAYRILRWRGELWVAEIKSRFAGSQARVKQPPQKKVVAHSVGKRKKGSALAVAEEEEGDPEQNNLDLAVHVDGDTSKLKKPHETDITAFVEALKRRGFLLNRDFGDNSVDMGNKMFVRMHFVKAAVPTRGKCVPKDGQEDTTKNKKGGQKPKPKFIEEKDEQEEVKDEAAVLKPCVYKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8J0</accession>
    <name>G0S8J0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Small nuclear ribonucleoprotein E</fullName>
            <shortName evidence="11">snRNP-E</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Sm protein E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0038260</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="15 16 17" key="2">
        <citation type="journal article" date="2025" name="Cell Res." volume="35" first="296" last="308">
            <title>Structural insights into spliceosome fidelity: DHX35-GPATCH1- mediated rejection of aberrant splicing substrates.</title>
            <authorList>
                <person name="Li Y."/>
                <person name="Fischer P."/>
                <person name="Wang M."/>
                <person name="Zhou Q."/>
                <person name="Song A."/>
                <person name="Yuan R."/>
                <person name="Meng W."/>
                <person name="Chen F.X."/>
                <person name="Luhrmann R."/>
                <person name="Lau B."/>
                <person name="Hurt E."/>
                <person name="Cheng J."/>
            </authorList>
            <dbReference type="PubMed" id="40016598"/>
            <dbReference type="DOI" id="10.1038/s41422-025-01084-w"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.80 ANGSTROMS)</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in pre-mRNA splicing. Binds and is required for the stability of snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site. Involved in cap modification.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694246.1">
        <property type="nucleotide sequence ID" value="XM_006694183.1"/>
    </dbReference>
    <dbReference type="PDB" id="9L5R">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="a/j=1-98"/>
    </dbReference>
    <dbReference type="PDB" id="9L5S">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="j=1-98"/>
    </dbReference>
    <dbReference type="PDB" id="9L5T">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.50 A"/>
        <property type="chains" value="j=1-98"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8J0"/>
    <dbReference type="EMDB" id="EMD-62841"/>
    <dbReference type="EMDB" id="EMD-62842"/>
    <dbReference type="EMDB" id="EMD-62843"/>
    <dbReference type="SMR" id="G0S8J0"/>
    <dbReference type="STRING" id="759272.G0S8J0"/>
    <dbReference type="GeneID" id="18257864"/>
    <dbReference type="KEGG" id="cthr:CTHT_0038260"/>
    <dbReference type="eggNOG" id="KOG1774">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125186_1_1_1"/>
    <dbReference type="OMA" id="VPPINCI"/>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01718">
        <property type="entry name" value="Sm_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000031">
        <property type="entry name" value="Small nuclear ribonucleoprotein E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027078">
        <property type="entry name" value="snRNP-E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11193">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="15 16 17" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="17"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS21950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="9L5R"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="9L5S"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PDB" id="9L5T"/>
        </source>
    </evidence>
    <sequence length="98" mass="10956" checksum="4462813969AC7965" modified="2011-10-19" version="1">MTSRGAPAGRRVLLPPINFLFRLLQQRTPVQIWLYEQLAIRITGVIRGFDEFMNLVIDDAVEIKLSPKTNEPESKRPLGQILLKGDNISLIQALSGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8K8</accession>
    <name>G0S8K8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Inositol-1-monophosphatase</fullName>
            <ecNumber evidence="8">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0038440</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="8"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694264.1">
        <property type="nucleotide sequence ID" value="XM_006694201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8K8"/>
    <dbReference type="STRING" id="759272.G0S8K8"/>
    <dbReference type="GeneID" id="18257882"/>
    <dbReference type="KEGG" id="cthr:CTHT_0038440"/>
    <dbReference type="eggNOG" id="KOG2951">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044118_1_2_1"/>
    <dbReference type="OMA" id="ERGLHPW"/>
    <dbReference type="OrthoDB" id="10254945at2759"/>
    <dbReference type="UniPathway" id="UPA00823">
        <property type="reaction ID" value="UER00788"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01639">
        <property type="entry name" value="IMPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000004">
        <property type="entry name" value="Inositol-1-monophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000012">
        <property type="entry name" value="Inositol-1-monophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033942">
        <property type="entry name" value="IMPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854">
        <property type="entry name" value="INOSITOL MONOPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854:SF4">
        <property type="entry name" value="INOSITOL-1-MONOPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS21968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="303" mass="32435" checksum="08BA7BCC38D59786" modified="2011-10-19" version="1">MADINLQAVHDLLVEVAFEAGQMIMAANTAKIKTDTKASDVDIVTETDRAVEAHVSARLRAAYPTFPFVGEETYIPGQTTITPAPTFIVDPIDGTTNFVHGFPAACISLGLAVDRVPAVGVVYNPFQDILYTAIKGKGAYMQRNASLPEGKGRGERVRLGENLTPLGDLRSALVGIEWGSQRDGPNYKVKVETFRKLAAAREDGGGMVGGLRSLGSAALNLCACAAGQLDMYWEGGCYAWDVTAGWCILNEAGGKVVGGNPGVWKPELTERIYLAVRGASAGQKELIEEFWGVIGDGRLEYKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8U7</accession>
    <name>G0S8U7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0043480</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694743.1">
        <property type="nucleotide sequence ID" value="XM_006694680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8U7"/>
    <dbReference type="STRING" id="759272.G0S8U7"/>
    <dbReference type="GeneID" id="18258386"/>
    <dbReference type="KEGG" id="cthr:CTHT_0043480"/>
    <dbReference type="eggNOG" id="ENOG502ST7S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017835_0_0_1"/>
    <dbReference type="OrthoDB" id="5396420at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS19858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="698" mass="78764" checksum="C61159A888D15828" modified="2011-10-19" version="1">MALLQTLRLNLRLNGHPQYTWQTENKNAGIFWPRDLLAMDVNGKARIWVYGHNSIPKERIPNIITDHGENLEHSLEQRVLSQNKDPIVFIAHSVGGLVIKHVVDDQFSKLGLEDHIEQVKQLGADHREMARCSSREDAKYKAMLNELLLLFAPTEHEASNPEPTKTSTKAVTGVMRDEYSGHTSRVGSTVARNTAVVGDNTMRQLFYSARVCRFSHVQPQRLSSYKWQWQQQCQRFSSSSSYVEHIKVPCASAGEITVSLHNIANHSATTPIAIYLPPFYRGANTVAPLPRCLQDHPVAVINYRWSPFTTKLEPGSTPLYWPIPLHDVTFAYNWLAENLGASTNYKPASGGDKLIPRPAYVVGSYLGASLAAALAMTECHRPMGENNYHMSVQGLIAYNGIYNWTTFLPDHPLHAKAAKRKRLATSKTNPEDGPPPYEEEGVFTTIKSQIPGLFGDNPENLFDPFASVCFFFHTPNLHVPDDFYTPLTDEDTELPPSLNKLVNILSDNKTQPPLNPEDISEDLHSLIRKVVTRMKLAKPARKSLLKYPPAESDLSLPPTLLLYSVQAPSHMKARKSRKRAKPPDHSKHYLNSFAHQAQDLASLLRIAGGEYELRRGIEKARTFLNTPSVGPEAEEARKFLEEQEINMARLMEDVRAEEVFVREGGQDEGGEVDQPFDGETGELVRKWLHERIEERRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0S987</accession>
    <name>G0S987_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0044950</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694883.1">
        <property type="nucleotide sequence ID" value="XM_006694820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S987"/>
    <dbReference type="GeneID" id="18258533"/>
    <dbReference type="KEGG" id="cthr:CTHT_0044950"/>
    <dbReference type="eggNOG" id="ENOG502S5M9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073624_0_1_1"/>
    <dbReference type="OMA" id="RIHILTI"/>
    <dbReference type="OrthoDB" id="2142503at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36854">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36854:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408919" evidence="3">
        <location>
            <begin position="25"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS19998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="218" mass="22833" checksum="F8DA42CC52EDDAD6" modified="2011-10-19" version="1">MARIRISFAFFLCAILSLATLASASVPTFCKCTCFKNSTIIPLGPQKPNQPPPQPPATTSKPPSTSTSTPRHHLPNPQALDPLQGRAASSSCSQCNRAFCLSYNLPICKDAEEKDVVASCFQRDSRKDRVIVWGFIVGTAGLLGWAGMRRVIFEGEKPFGFGGGRRRESPGGGRGGGSVGGIGGGGVSTRGGGVFARRTAPVAEYNPLEGEAGPVRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0S997</accession>
    <name>G0S997_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0045050</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694893.1">
        <property type="nucleotide sequence ID" value="XM_006694830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S997"/>
    <dbReference type="STRING" id="759272.G0S997"/>
    <dbReference type="GeneID" id="18258543"/>
    <dbReference type="KEGG" id="cthr:CTHT_0045050"/>
    <dbReference type="eggNOG" id="ENOG502R4GW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024451_0_0_1"/>
    <dbReference type="OMA" id="MINGMMR"/>
    <dbReference type="OrthoDB" id="2117459at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047168">
        <property type="entry name" value="LEC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024554">
        <property type="entry name" value="LEC1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024555">
        <property type="entry name" value="PX-associated"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185:SF2">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN YPR097W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12825">
        <property type="entry name" value="DUF3818"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12828">
        <property type="entry name" value="PXB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX-associated" evidence="3">
        <location>
            <begin position="37"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="204"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="389"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS20008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="759" mass="83902" checksum="227507CA9A725BEB" modified="2011-10-19" version="1">MSLTSGSLSFSAQHSLPADQPTLVRCLYPSSLAGASKTTLHALFDILSHHETYREVRSFREPETISHYGHPFTLRNTKASWTASHATDSSAPLFAGVFRSIVLTIPGIRDLPGEFWNVRLQGILEKFAEVGLSESYDKCTVSTRKTLATAASAIHGVVSRGVLGGVAKGPRRDLHGHYERSKAEDLEKAWEDVVHELLYGDLIDELFAFATETENLEEHSPAVHAAADYIILHLASLIHHVVVLSPDGPYIIRLLEGVHKLLPYTMIKKILRIGNAATMVQGMMRLLLAKVSVGALSNWVGLTQNAKDGMNLLQSFDHRKITERIEKETGGDSPPQECLDALKRYAARPREEHEFIRNLSMENSTSMVATILGFTNPDFLSALSEAQHSRCHQYFAELIITRDLEEIINILCRQTPDLFTQALKDIVATFDPIIREVHEHIDLREYVSATESFLTDFINLSKGTPATSSRLSSFAAAFRKSDTVKARTPSVEDYVDLLRRNKHIIYRWVHQVAARCPTIRDEFHAWAKESAKVFQRATKEASSSPINPENEHEGAGALSNGLQNLWLSLPPDTRSNILPSIDAHAKYLAELKQLSRARMQRILDNIHSISPTPSPVNSQFSATVSCSHPSLSESPQTSTPLSGSPCDTSTSYTSSHTFPVSRSNSPLRLTSTGSHTGPGMYLSRWENLLNTTPIGPATARGPIRSGREVRPKPVVGDVWEMAGEPKPPDVEKVVVALEEGFRRLVGSKMKGRGDLGLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0S998</accession>
    <name>G0S998_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Small ribosomal subunit protein mS35 mitochondrial conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0045060</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694894.1">
        <property type="nucleotide sequence ID" value="XM_006694831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S998"/>
    <dbReference type="STRING" id="759272.G0S998"/>
    <dbReference type="GeneID" id="18258544"/>
    <dbReference type="KEGG" id="cthr:CTHT_0045060"/>
    <dbReference type="eggNOG" id="KOG3933">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051514_0_0_1"/>
    <dbReference type="OMA" id="CEKFEHQ"/>
    <dbReference type="OrthoDB" id="283424at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019349">
        <property type="entry name" value="Ribosomal_mS35_mit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039848">
        <property type="entry name" value="Ribosomal_mS35_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10213">
        <property type="entry name" value="MRP-S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small ribosomal subunit protein mS35 mitochondrial conserved" evidence="2">
        <location>
            <begin position="217"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS20009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="392" mass="45215" checksum="45388107080FC7E3" modified="2011-10-19" version="1">MASPAQILRLCVRSTGTGSSRLAAAVANHRVAAVVALSKRPQLQHQISPAAVTMIARRPISTTPSRRSDDEADEDEEDDDAPGAWGLPEVTFMSPDEILSHIANSESSSEAERQAARELLERWQKVPARDREELERLELEMMQTVRRGAVPKPRKDTFWNEEESDRDLITDEVGEDDFDEDDMTAMAHAKLEEHREYRHYARVAIWEMPLLAKLAKKFEPPTQEQVLRFRYTTYMGEWHPGDRKVVVEFCPSDIPGLTEEQQLKLKKLAGARYNPEKDIVRMSCERFEHQAQNKRYLGDLDPTDTFADIPLDTRHHEFKKPIKFPREWYLTPERKQQLLEERKRALLLDEQKREQGLLVDGRKVVEQALKQPVPVGVRMVRGGPQGQQQRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9U1</accession>
    <name>G0S9U1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0047170</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF8 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695087.1">
        <property type="nucleotide sequence ID" value="XM_006695024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9U1"/>
    <dbReference type="STRING" id="759272.G0S9U1"/>
    <dbReference type="GeneID" id="18258755"/>
    <dbReference type="KEGG" id="cthr:CTHT_0047170"/>
    <dbReference type="eggNOG" id="ENOG502SG72">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026584_1_0_1"/>
    <dbReference type="OMA" id="HDWIYAL"/>
    <dbReference type="OrthoDB" id="2193813at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00076">
        <property type="entry name" value="HFD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037818">
        <property type="entry name" value="TAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019473">
        <property type="entry name" value="TFIID_su8_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46469">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46469:SF1">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10406">
        <property type="entry name" value="TAF8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromodomain associated" evidence="8">
        <location>
            <begin position="64"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor TFIID subunit 8 C-terminal" evidence="9">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS20202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="371" mass="41090" checksum="D0E90B4A29433CCD" modified="2011-10-19" version="1">MATAFFEAKAKGMPTESRKRPLEADQQTASASTKRPKLMSPYTILFAERPGSSPHHSFMETTDALAKAGLRRSIALVLQKVGFDTATPEAFESFVLMAEEYLTSMIEDVKHFTNAARRSYPIPTDFEQTLKRFNLTTSALKPHKKPPIPRSKRIPVYESLPGEDGIVPDLPILGPELDGAKDKASKPYIPASFPAFPSIHTYKYTPESVDAVTVSDDWGIFDPDAPLEPIEGSPVPQPQRPLAAEEIPHGDPKKIREAAAKEAKAGEEALRRLMRASKVAKQKEIRSAAQRQAARRDRYNLWEMAMKEMLEDGTKGKRREGGMICSLVNGDKNRVEIADHSMIVSTEKAYCRKEVPRPGVRKAVGNAAGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9V5</accession>
    <name>G0S9V5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0047320</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695101.1">
        <property type="nucleotide sequence ID" value="XM_006695038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9V5"/>
    <dbReference type="STRING" id="759272.G0S9V5"/>
    <dbReference type="GeneID" id="18258770"/>
    <dbReference type="KEGG" id="cthr:CTHT_0047320"/>
    <dbReference type="HOGENOM" id="CLU_1415008_0_0_1"/>
    <dbReference type="OrthoDB" id="4842715at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS20216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="20556" checksum="FC1E711C9178A771" modified="2011-10-19" version="1">MVGNGRVISDTERMAAYLATQALACRGQEGSRPAWPGPRLPPEWAVRLADPPSDNELRDAFFGTTSNTPSPDGVPLTFLRHTWELVRPATRAIAEGCIKWGAFPKAFKQATVVTLSKPGRDPPSYKGWRPITLLRLSTFGKGVEMTAAALNSGLLPPDVAGAVSSRSALDLVQALVHAGINGRLVPYRLASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0SA01</accession>
    <name>G0SA01_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0040510</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694458.1">
        <property type="nucleotide sequence ID" value="XM_006694395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SA01"/>
    <dbReference type="GeneID" id="18258089"/>
    <dbReference type="KEGG" id="cthr:CTHT_0040510"/>
    <dbReference type="HOGENOM" id="CLU_133936_0_0_1"/>
    <dbReference type="OMA" id="GATQSMW"/>
    <dbReference type="OrthoDB" id="5280466at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409429" description="CBM1 domain-containing protein" evidence="4">
        <location>
            <begin position="18"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="5">
        <location>
            <begin position="30"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS19573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="131" mass="14255" checksum="2B47613C6A0514C2" modified="2011-10-19" version="1">MAKLFFPLASWLGASYALPQWPPNPPVSQPTQTLWGQCGGVTYEGPTLCPNNAYCYNDGNIWYSQCIPIETTQNQPPATVRTITTIFSVGGPTPTVVSTRITYYQPPTPTTLPVVTVTLVPDEPCNVGYLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAA1</accession>
    <name>G0SAA1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyl transferase family 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0041520</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694558.1">
        <property type="nucleotide sequence ID" value="XM_006694495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAA1"/>
    <dbReference type="STRING" id="759272.G0SAA1"/>
    <dbReference type="GeneID" id="18258190"/>
    <dbReference type="KEGG" id="cthr:CTHT_0041520"/>
    <dbReference type="eggNOG" id="ENOG502RYA1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054222_0_0_1"/>
    <dbReference type="OMA" id="AHEKWFL"/>
    <dbReference type="OrthoDB" id="512920at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12526:SF510">
        <property type="entry name" value="D-INOSITOL 3-PHOSPHATE GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12526">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13692">
        <property type="entry name" value="Glyco_trans_1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS19673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="50214" checksum="1296065865CD872D" modified="2011-10-19" version="1">MRVFLVQTAQGLTPSSGGYKANVNLLRALSSQGHTTAQICYGAEPEIDEYATRSTIYGPSVISDLDVDVIKVTDIRNVEHEIKVNTFTDEYGVFNICFDLNITGRMKALIDFYSSWISRFQPTHVVFNDPTTMKITETHPLRHTFKRINIIHTAEQLPFGPFVNGVAGHCLAPKAEDRLLRGLDGIWTVSKAIHDYAWTHGKLKTTFLIHPSRTYLDHKTGQMPMARNNVDKDEIGMVNPCPHKGISILLALAKRFPHLKFVTWKSWGTSRDHLAELLALPNIRVESTTEDMDEVWDRIKVLLAPSLWLEAWGIVVTEAQLRGIPVIASNAGGLAEAKIGLPYCIPVKIVTGERHPNGDYIVAEQDIDPWAEALETLMTDRTAYEALAKLTAIKAAEWLRSLDDRAHEKWFLSMMDDNKINGTKALAEDDLEDTNDEQALQCAVKQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAA3</accession>
    <name>G0SAA3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0041540</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694560.1">
        <property type="nucleotide sequence ID" value="XM_006694497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAA3"/>
    <dbReference type="STRING" id="759272.G0SAA3"/>
    <dbReference type="GeneID" id="18258192"/>
    <dbReference type="KEGG" id="cthr:CTHT_0041540"/>
    <dbReference type="eggNOG" id="ENOG502T61C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_739667_0_0_1"/>
    <dbReference type="OMA" id="FETHRAN"/>
    <dbReference type="OrthoDB" id="610608at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="49170" checksum="F971427105100C80" modified="2011-10-19" version="1">MHHRAKRPAFQCPRCRSQLANVAALEQHLLMPREQMCEVNAEEPVFDREDGITEELAALLSGKDSKNEVWTWETICQVLFPGDPLMDTVELFEIDQIFDDTQDTLKSNLREKLRMLLPPNIIDDEYCSFLSTQLDLVFETHRANIVRRCLAYATGNKDTGVGSERTSEQRNGRRMSVKKPARISRRSTLMQSIQHHTTGNKHTRTLSLKPTVGTGVRECGHWRKTSNALPVNTSYVPMGAVKTNTTTNETPLTKDTNDNDNQTHISEIEPGSREQRDSGISIPNSSHSPQGSMLPDESDNSEPPTPSSCPSTSTDISDAQDTDTQQPAQPLPNPTSTLSKRLKPRPGRLNLNVGVGLGLGLGIDIPLTPSTILANQFESISAGGAGHATDRKGSNERGYLGECLTAPLPIDSPRGRNAEDGECHGGLFSPESFKQRVLRGRMSGVLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAF3</accession>
    <name>G0SAF3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0042070</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694610.1">
        <property type="nucleotide sequence ID" value="XM_006694547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAF3"/>
    <dbReference type="SMR" id="G0SAF3"/>
    <dbReference type="STRING" id="759272.G0SAF3"/>
    <dbReference type="GeneID" id="18258245"/>
    <dbReference type="KEGG" id="cthr:CTHT_0042070"/>
    <dbReference type="eggNOG" id="ENOG502QU2T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_1_1_1"/>
    <dbReference type="OMA" id="NYWHGDL"/>
    <dbReference type="OrthoDB" id="2310150at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19075">
        <property type="entry name" value="AKR_AKR7A1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="8"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS19725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="346" mass="38644" checksum="AC2F502CC5BF9845" modified="2011-10-19" version="1">MASQKPRVILGLMTFGPDPSTGARVTSPSDFAAVLDLLQQRGYNEVDTARMYVGQKQEAWTRDHGKWKERGLKLATKVIYPHEKGSNSYEGVVKSVGESLEALGTDRVDILYLHAADRATPFAETLRAINDLYSQGKFTTFGLSNFTSFEVAEIVLTCHQNNWVRPTLYQGMYNAITRSLETELIPACRRYGLDIVVYNPLAGGLFSGKIKSKDLVPEEGRYSDTARSGKLYRDRYFRDSTFHALKIVEEAAEKAGLTLIETALRWLVHHSKLRVKDGNDGVIVGVSRLEQLGENLDALERGPLPDDVVRALDEAWRVSKGDTTNYWHGTVEYGYDTVKVLFGKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAJ2</accession>
    <name>G0SAJ2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0042480</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694649.1">
        <property type="nucleotide sequence ID" value="XM_006694586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAJ2"/>
    <dbReference type="GeneID" id="18258286"/>
    <dbReference type="KEGG" id="cthr:CTHT_0042480"/>
    <dbReference type="HOGENOM" id="CLU_906144_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="307" mass="32381" checksum="CCFE029AB364584D" modified="2011-10-19" version="1">MSRDNSIVIEVEVADSTEVTWPHALNSPPFDKELFGDGEKAKNTLPDGFPCSFECGAEGEYAIQNQGVTNDSPTDSSGSDEGLVMQTEGREEIKTSVNITSESAATANISVDIDVESPPEVFTKLKSAIVLTPCFIIGSNSDSSSSSSSNDDLALPSLPEQPRSQPVDIPKLALQDIKKETGAMDTPGVAHAAISPDLLFPTDSDEGNDADTELTPSSSSSPPSMLSMPMRETETTNEKPTVNEALAAADPSSSSSISSRGEDTPSTGSSDSIDFEIHSSSDIRLAMELDKEKARAGEVINTLESDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAP2</accession>
    <name>G0SAP2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Polyadenylate-binding protein</fullName>
            <shortName evidence="14">PABP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CTHT_0042990</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation. In the nucleus, involved in both mRNA cleavage and polyadenylation. Is also required for efficient mRNA export to the cytoplasm. Acts in concert with a poly(A)-specific nuclease (PAN) to affect poly(A) tail shortening, which may occur concomitantly with either nucleocytoplasmic mRNA transport or translational initiation. In the cytoplasm, stimulates translation initiation and regulates mRNA decay through translation termination-coupled poly(A) shortening, probably mediated by PAN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the polyadenylate-binding protein type-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694699.1">
        <property type="nucleotide sequence ID" value="XM_006694636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAP2"/>
    <dbReference type="STRING" id="759272.G0SAP2"/>
    <dbReference type="GeneID" id="18258337"/>
    <dbReference type="KEGG" id="cthr:CTHT_0042990"/>
    <dbReference type="eggNOG" id="KOG0123">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_22_4_1"/>
    <dbReference type="OMA" id="QQPGFMP"/>
    <dbReference type="OrthoDB" id="19742at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12378">
        <property type="entry name" value="RRM1_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12379">
        <property type="entry name" value="RRM2_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12380">
        <property type="entry name" value="RRM3_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12381">
        <property type="entry name" value="RRM4_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1900.10:FF:000004">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000003">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000355">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000384">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.10">
        <property type="entry name" value="c-terminal domain of poly(a) binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036053">
        <property type="entry name" value="PABP-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006515">
        <property type="entry name" value="PABP_1234"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002004">
        <property type="entry name" value="PABP_HYD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034364">
        <property type="entry name" value="PABP_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045305">
        <property type="entry name" value="RRM2_I_PABPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01628">
        <property type="entry name" value="PABP-1234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00658">
        <property type="entry name" value="MLLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00517">
        <property type="entry name" value="PolyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63570">
        <property type="entry name" value="PABC (PABP) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51309">
        <property type="entry name" value="PABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 13 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="68"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="156"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="249"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="352"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="PABC" evidence="17">
        <location>
            <begin position="667"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="27"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="381"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="613"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="747"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="383"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="647"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="747"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="763"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGS19814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="777" mass="83921" checksum="F63000E7F79EBE70" modified="2011-10-19" version="1">MAAPASTAVDQLAADLNNVSLNGGANGAAPAADTAVASGETQTAQSETTAPAAATTTTSTAPHPQASASLYVGELDPSVTEAMLFELFSQIGSVASIRVCRDAVTRRSLGYAYVNYNSVADGEKALEELNYTLIKGKPCRIMWSQRDPALRKTGHGNIFIKNLDAAIDNKALHDTFAAFGNILSCKVATDENGNSKGYGFVHYETDEAAAQAIKHVNGMLLNEKKVYVGYHIPKKDRQSKFEEMKANYTNVYIKNINLEVTEEEFREFFSKWGEITSSTLARDAEGKPRGFGFVNYSTHASAAKCVEEMNGKEWRGQELYVGRAQKKHEREEELRKSYEAARLEKQNKYQGVNLYIKNLSDEVDDEKLRAMFAEFGPITSAKVMRDTPPEPAKDEKNKENNKESEKEGEKKEGEGEGDKKPEVKKPERKLGKSKGFGFVCFANPDDATKAVAEMNQRMVDGKPLYVALAQRKEVRKSQLEASIQARNQLRMQQQAAQAGLPQYMQPPVYYPGQQPGFLPPAAGRGMPFPQGALGMPPVQGGRPGQFPPYPQQAGRGTIPPQVPMYPIGQFPGAYPQPNNPQFLAAMQQVQQAAALAGGRGAPAGRGVPTVPIPQGIQAPGLAGYPPNGRPQNGNLGRGAGPNRSNFPAGRGAPPAGPLGVPGELSPAALLQSQLAATTNPQQQKQILGENLFPKVQALQPELAGKITGMLLEMDNQELINLIEDEAALVAKVNEAMAVYEEYVKSQQAQQGQAPAAAPQAEAAAEKPKEEKAEEQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAR9</accession>
    <name>G0SAR9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Monooxygenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0043260</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694726.1">
        <property type="nucleotide sequence ID" value="XM_006694663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAR9"/>
    <dbReference type="STRING" id="759272.G0SAR9"/>
    <dbReference type="GeneID" id="18258364"/>
    <dbReference type="KEGG" id="cthr:CTHT_0043260"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_27_2_1"/>
    <dbReference type="OMA" id="SWFVKCE"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24296">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408959" evidence="6">
        <location>
            <begin position="27"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS19841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="523" mass="58353" checksum="1BD3BF2748D7F93B" modified="2011-10-19" version="1">MGFIIDMIPHLVLAALLAILIRTVSRQRPVITRNGRPLRKPPGTLLLIGNGFKFLQPRWQLFSWFNKCQQQFGYETVALTVPTLPPGVLVHDPKVLNFIFKNEGLFAKGAFVKKRTWDLFGDGIINADGDLWKLQRKAGAAFLTPANLRVLTDVALPQYLGEAVSELTAKADGKTIVDLQHIFHEITSKIMGKMAYNMEMHADEDFTKSFDFASGGIAERFQNPFWQLTERFTGSKLRKSIATVKDYGQHIVSRAVTDRSFSNPDLKSSKLDQISGSLIQSLLNSIPDHATVANAALTYLSAGRDTTAQALTWAFYLLLRHPTYLTKIREELTHFLAQDLPSDLENPLPINPTLLTPSSAPYTLAVFYETIRLYPPIPFEIRQCKAPPGTTTTLPDGTVLPHGAVLVWCLFALQRSKLTWGEDADRFRPERFLVEVDGPGDGRKRISFQLGKTTGEFPVFYGGSRTCLGRRMAEAVAVQVIAVLAWLFEFEEVDKSRERISGSSLTLPMEGGLPVRVKRCGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAT5</accession>
    <name>G0SAT5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative mitochondrial peroxiredoxin prx1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0047710</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695137.1">
        <property type="nucleotide sequence ID" value="XM_006695074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAT5"/>
    <dbReference type="STRING" id="759272.G0SAT5"/>
    <dbReference type="GeneID" id="18258809"/>
    <dbReference type="KEGG" id="cthr:CTHT_0047710"/>
    <dbReference type="eggNOG" id="KOG0854">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_4_2_1"/>
    <dbReference type="OMA" id="HGPMNIP"/>
    <dbReference type="OrthoDB" id="2996783at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1020.10:FF:000001">
        <property type="entry name" value="1-Cys peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000011">
        <property type="entry name" value="Peroxiredoxin PRX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1020.10">
        <property type="entry name" value="Antioxidant, Horf6, Chain A, domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF4">
        <property type="entry name" value="PEROXIREDOXIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4 6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="10"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="7">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS19315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="225" mass="25306" checksum="486089C9EE1EF6BC" modified="2011-10-19" version="1">MATEVEQPRLRLGSIAPNFKAETTKGPIDFHEFIGDSWVILFSHPEDYTPVCTTELGEMARLAPEFAKRGVKLIGLSANTLDSHEGWIKDIKDVTGSLVDFPIIADKERKVAYLYDMIDYQDTTNVDEKGIAFTIRSVFFIDPKKVIRTILSYPASTGRNSAEILRIIDSLQTGDKHKVTTPINWVPGDKVIVHPSIKTDDAKKIFPNVEIVKPYLRFTTLPEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0SB40</accession>
    <name>G0SB40_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0048790</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695242.1">
        <property type="nucleotide sequence ID" value="XM_006695179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SB40"/>
    <dbReference type="STRING" id="759272.G0SB40"/>
    <dbReference type="GeneID" id="18258917"/>
    <dbReference type="KEGG" id="cthr:CTHT_0048790"/>
    <dbReference type="eggNOG" id="ENOG502QS7Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020266_0_0_1"/>
    <dbReference type="OMA" id="LLWRHHC"/>
    <dbReference type="OrthoDB" id="28868at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.390">
        <property type="entry name" value="Hemimethylated DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011722">
        <property type="entry name" value="Hemimethylated_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036623">
        <property type="entry name" value="Hemimethylated_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032698">
        <property type="entry name" value="SirB1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31350:SF27">
        <property type="entry name" value="HEMIMETHYLATED DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31350">
        <property type="entry name" value="SI:DKEY-261L7.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13369">
        <property type="entry name" value="Transglut_core2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08755">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00992">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141255">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="4"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="639" mass="73862" checksum="CF026B253295FCB1" modified="2011-10-19" version="1">MPMRSSLCDIPDEIVRHILWYLPPEDTLLSFQLLSRRYHHIANEPLLWRWYCQKSFRYWHPRHRFHEKLAALASSVDWKGLWITRKQINKRIAQLLNEVLRTKVGQMRNLGQICEMGYDAKDYLLEQCHCDENAEDVLARRYYAHTALDSIHRGVAVEVWSRYQGQPLSYRGLDTALGAFDMFVLHDQPYDLDYIVHELDAIADRFRAEHPTFEELTTRQKALTLVRWLRANNLTGMDHPDLYYRSLRNCFIGHALSDEEHPSLPIISSAIFTCVAERLGLHAACLAFPSHVHAAVFAPPGRTLDGRPVEDPKAEPEKMCLDPYGSDNEITLRDLRRRLVEFGWQSGTNAFLTPSPVPIIVQRTAQNIKATHDTVHSLANTSVEEDRLAEELKRLRSGHPMRNLSAAVYASMWADLLMKQTTSFHWDTNLGAFLKCFALSWSEDTWIVRKYLAPLYEEFIANKNALNHGAAAANNRRRRSGWENLHEIVAMLENLDNRQPTVSRRYTADINARVRYRIGQVFRHRRYQYVGVINGWAATGSAGLPMPHYLDAAEAEEEGDVFDPTESVRASNAVPQRTFYTCLKSTVDRLRVAQENVVPITDPREIPEELFFVAGKFFKRFDPERCMFVSNIKEYYPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G0SB64</accession>
    <name>G0SB64_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ARF guanyl-nucleotide exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0049050</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695266.1">
        <property type="nucleotide sequence ID" value="XM_006695203.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0SB64"/>
    <dbReference type="GeneID" id="18258943"/>
    <dbReference type="KEGG" id="cthr:CTHT_0049050"/>
    <dbReference type="eggNOG" id="KOG0929">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001772_0_0_1"/>
    <dbReference type="OMA" id="FYTSIQK"/>
    <dbReference type="OrthoDB" id="2157641at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF373">
        <property type="entry name" value="PH AND SEC7 DOMAIN-CONTAINING PROTEIN C11E3.11C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="750"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="903"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1017"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1204"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1323"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1390"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1515"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1568"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="660"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="916"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1071"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1323"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1353"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1393"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1515"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1568"/>
            <end position="1577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS19444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1592" mass="173642" checksum="FA2499FB14589ECC" modified="2011-10-19" version="1">MLPTDSARRSGRRKPDLSIDTSPPLRPSRSRDRIGIPHTPISSHKDGLAPAAPIIPAGGGPSGRSKADIETFLEGLTPVDVPPIDMTNPIPIEHDSPSSDPDNCPTNDRDSTDSHDLSLSPRNVTRDSLVANMLLSLDKLTLGQLDSSYGPSRSVFDEPPIYSPFHSDDRDPRSMTFASRSGRPGHQYSYSSDFDAADDSSRLSSRGRRSNSGSGFQTGIGRINSMRETSQRSPGRVLHSRGRKGSKSSSSTSIDAGYAQVLGSQRWTRGFGGRPSSFDGEPQPSPAAWQLELSNSFFNDGFDAAPTPTVPGGPRKLNNVPSLPIMPAPPPPPPPPPPPEPKSELKPSSKGGSSALPRSGRSSRSSTIARKTEKFTSPREPPPIPTYDFDSAPAPHIGYEKSKDAQLSTANNTTKESKPGFFRRMFGSAKSVVPSSVSTPQLAFPSLQAKSSTPPSREGVVSAAHTLQKKTSSFFRRRKHSVTETDHPPPVPPVPPVKLPLDKPEPSPMPSLRRAMDPFLQGSSGTSAAQTPADTPLPSAENPLDTVQHQHEQTTPRRPTDDEARKPTRGFSPDYDPSPKAVIRKVDSEPVSGQGSRPVATTPHRSGLEPDVGSPPQSFLRDNSDSEDSPVRQRKTPWSESREQGLRPGPDPDILRTRTPSPVMSKSKSVPNLNRAREEARPRPGQSKRPPSVTRNDRRDSNLLDAGGETMYKPSLPSLRIESAEPSPNGMGAGESVNQSAKSIDEPEVIVGDPTEDDRQKARKIFDGNEDFISKDRAAAWMGEEGTVRQRTLRAFMELFDFEGQSIVASLRQVCERLLLRAETQQLDRILVAFSKRWCECNPNHGFKSVDVIHTICYSIMLLNTDLHMADIEKKMTRSQFVKNTMTTIRQALEDSAPEAFEKPSILPGKSALGEAEPRTSEDHKHNSFRYSFKPPPRPTSALGNMGDHAATESCGPLVKAPFDGSLRDWEEQVEIVLKNIYSSIRDDRLPLLGGAEPSPMHTPNTLSVMGMLRRSPSVLSKAPSEGVASTHRGRMPVAGPPSSSSRWNSKSRSRPRGFGTGFSSSRTSFEDSNSVWSPTESSATWSKLSLGRTHTSMSMDSFGSAYPRGEYQQSIGFANALSQAIIREDNPDDHKDDIRHDQLLEDESLELAGPPWVKEGIVVHKHHLDGIDKKAKDRNWTEVFAVIQKGQLSLFSFSPNKSLRNKGRRGPGHNNSLPKGAVVGGGNWQDNATNLGTFSLRQTLASALPPPGYSRTRPYVWALSLPTGAVHLFQVGTPEICKEFVNTVNYWSARLSTHPLTGGVSNIEYGWSDAVINSVQRTSTNDGVANRPASSTKGHSRPGSSATAAITAGRSSMQSGRSMRSASFDFPVRPGSGSSGVLGGTLPRHFTNSSNPGISSSSSGKNEGKLPGDRIHIVDWTPPPQSMRASPLSEAEQLASLEAYVRSIETELQTHNALRGPMLQAFSPRSANAAKAMANWERKSEYLLRESVKFRTYVESLRFAEQRKREVYEERERARRAARGEDVDDLDEAEKEQQKKEGEEKEDVVVDVEALREVGEYLKRVQKEEDEKKDGVVAEGGGVQVTVGSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBA7</accession>
    <name>G0SBA7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pectate lyase</fullName>
            <ecNumber evidence="10">4.2.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0049540</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Pectinolytic enzyme consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins. Favors pectate, the anion, over pectin, the methyl ester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan to give oligosaccharides with 4-deoxy-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the polysaccharide lyase 3 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.2" evidence="10"/>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695309.1">
        <property type="nucleotide sequence ID" value="XM_006695246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBA7"/>
    <dbReference type="STRING" id="759272.G0SBA7"/>
    <dbReference type="GeneID" id="18258992"/>
    <dbReference type="KEGG" id="cthr:CTHT_0049540"/>
    <dbReference type="eggNOG" id="ENOG502SHHK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044863_3_0_1"/>
    <dbReference type="OMA" id="CKTQYQR"/>
    <dbReference type="OrthoDB" id="441042at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004898">
        <property type="entry name" value="Pectate_lyase_PlyH/PlyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407">
        <property type="entry name" value="PECTATE LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407:SF9">
        <property type="entry name" value="PECTATE LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03211">
        <property type="entry name" value="Pectate_lyase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025096415" description="Pectate lyase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS19487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="274" mass="29046" checksum="035D782A88873139" modified="2011-10-19" version="1">MQSTTLLLLVASLAGAQTNTNLQTVFPTATKTTALSAAKTIAAGQTFDGQMLQWDRSPSTCNGQSEGGEKDALFILEDGATLSNVIVGPNNGEGIYCKGTCTLNNMLVSPRVPLPSISTIFIYWRILTNNNSWWTDVCEDAATFFQKSGTSYVNGGGARNADDKVFQHNGGGTVKVKNFFASNIGKLYRSCGNCKTQYQRHSTFENIRVVDKASVVAGVNVNYGDTTQINNSCVLKGGLCWLYEGNSSGKEPTKVGSGPSGTACATQAVQTSGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBM7</accession>
    <name>G0SBM7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peroxidase</fullName>
            <ecNumber evidence="14">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CTHT_0054130</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 Fe(II)-[cytochrome c] + H2O2 + 2 H(+) = 2 Fe(III)-[cytochrome c] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:16581"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.11.1.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Forms a one-to-one complex with cytochrome c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="14"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695748.1">
        <property type="nucleotide sequence ID" value="XM_006695685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBM7"/>
    <dbReference type="STRING" id="759272.G0SBM7"/>
    <dbReference type="GeneID" id="18259451"/>
    <dbReference type="KEGG" id="cthr:CTHT_0054130"/>
    <dbReference type="eggNOG" id="ENOG502QR1E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036959_1_1_1"/>
    <dbReference type="OMA" id="QRKWNGP"/>
    <dbReference type="OrthoDB" id="2859658at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004130">
        <property type="term" value="F:cytochrome-c peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00691">
        <property type="entry name" value="ascorbate_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000009">
        <property type="entry name" value="Ascorbate peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000005">
        <property type="entry name" value="Cytochrome c peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002207">
        <property type="entry name" value="Peroxidase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF58">
        <property type="entry name" value="CYTOCHROME C PEROXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00459">
        <property type="entry name" value="ASPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 14" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="16">
        <location>
            <begin position="103"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGS18803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="355" mass="39697" checksum="03E6673DF69C5123" modified="2011-10-19" version="1">MATATRTFARALRTSARPALSAAPRIAFRQSGHRFYSSEPAKKGSSAWLWLTGAAAAAGGGAYFYLNGSTPVTPKVFEPKFEDYQAVYNEIANRLEEDENYDDGSYGPVLLRLAWHASGTYDKETGTGGSNGATMRFSPEADHGANAGLKAARDFLEPVKAKFPWISYSDLWIIGGICAIQEMMGPKIPFRPGRQDKDVSACTPDGRLPDAAQGQDHLRNIFYRMGFNDQEIVALAGAHALGRCHPDRSGYSGPWTFSPTVLTNDYFKLLLEEKWQWKKWNGPKQYEDKKTKSLMMLPADMSLVQDKEFKKWVQKYAADNDLFFKDFAAVITKLFELGVPFKEDTPTYVFKSTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0SC51</accession>
    <name>G0SC51_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0055950</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695922.1">
        <property type="nucleotide sequence ID" value="XM_006695859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SC51"/>
    <dbReference type="STRING" id="759272.G0SC51"/>
    <dbReference type="GeneID" id="18259633"/>
    <dbReference type="KEGG" id="cthr:CTHT_0055950"/>
    <dbReference type="eggNOG" id="ENOG502QWNS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049343_0_2_1"/>
    <dbReference type="OMA" id="RDTIFHE"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF52">
        <property type="entry name" value="4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="2">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS18977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="352" mass="38005" checksum="09968A439DACE7F6" modified="2011-10-19" version="1">MESFQLSISNPLTPTSLLNAMDQMEEDDGPTVLPNGVYVPMPAFFTPDDELDIPAIQRHTARLLAAGVSGLVVHGSNGEAVHLSRAERRATIKAVADTVRHEKTDLHRPIPIIAGCSAQSIRETLELCIEAYEAGATHAIILPPGYYASLLTKPAVIDFFTTIASRSPIPILIYNFPAAANGLDLDSDTLLTLASHPRIVGVKLTCGNTGKLARLVAGTASSEFFIAGGSADFILQGLVVGAHGTICGFANLAPRACVRIFELWEQGRIKEARTLQHEVAKGDWLAIRYGFVGVKAAMPIFHGDAERGCAVPRLPFKPLMKDGPEVEEIRRGMEGVLRVERRLAEEARARGR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-03-16" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0SC91</accession>
    <name>FKBP4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName>FK506-binding protein 4</fullName>
            <ecNumber evidence="1">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Histone proline isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName>PPIase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName>Rotamase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">FPR4</name>
        <name type="ORF">CTHT_0056370</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">PPIase that acts as a histone chaperone. Histone proline isomerase that increases the rate of cis-trans isomerization at prolines on the histone H3 N-terminal tail. Proline isomerization influences H3 methylation thereby regulating gene expression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Binds to histones H3 and H4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FKBP-type PPIase family. FKBP3/4 subfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="4">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EGS19017" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="1"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19017.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695962.1">
        <property type="nucleotide sequence ID" value="XM_006695899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SC91"/>
    <dbReference type="SMR" id="G0SC91"/>
    <dbReference type="STRING" id="759272.G0SC91"/>
    <dbReference type="GeneID" id="18259675"/>
    <dbReference type="KEGG" id="cthr:CTHT_0056370"/>
    <dbReference type="eggNOG" id="KOG0552">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005146_1_0_1"/>
    <dbReference type="OrthoDB" id="77911at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.340">
        <property type="entry name" value="Nucleoplasmin core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041232">
        <property type="entry name" value="NPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023566">
        <property type="entry name" value="PPIase_Fpr3/Fpr4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811:SF19">
        <property type="entry name" value="39 KDA FK506-BINDING NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811">
        <property type="entry name" value="FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17800">
        <property type="entry name" value="NPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001473">
        <property type="entry name" value="FK506-bp_FPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0697">Rotamase</keyword>
    <feature type="chain" id="PRO_0000435811" description="FK506-binding protein 4">
        <location>
            <begin position="1"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="2">
        <location>
            <begin position="397"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="41"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="208"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="241"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="298"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q06205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="483" mass="53290" checksum="EC55ADF9847D4A55" modified="2016-03-16" version="2">MSSLLPVAVYGLEVPPGDILVPAQFEFPATIRITMAAIDPTAEPETDGQGNVPTVPRSTLKLIKTTAEEDDDEYLDIDGEDSEDDEESDDEEVNGGPSDPAKSKKARREAAIKKLLEATKEESDEEMEDADAKPNGKGKKDSKGKAKASESDDEKSDEDDEEGEPNFEEFVVCTLDTERTYQQPIDITITEGEKVFFVVKGTHKVYLTGNYVLPEGQDEEDDEDEEDYSDEEYDLPHGIELESDSDYESDELDEIDGTPRIKEIDTDEEEEEAPKLVDTSKKGNKKRPAEEAENLDDLVAKDKKQAEKQKKLKNNKGEAVPAENKDVKKEGKSDKKVQFAKDLEQGPSGPAKDKLEKKEEKKDDKADLKKPSLGVKVVQGVTIDDRKLGTGRTVKSGDRVSLRYIGKLTNGKVFDANKKGAPFTVRVGKGEVIKGWEIGLIGMQVGGERRLTIPPHLAYGSRAMPGIPANSTLVFDIKLLEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCD5</accession>
    <name>G0SCD5_CHATD</name>
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        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0056830</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696006.1">
        <property type="nucleotide sequence ID" value="XM_006695943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCD5"/>
    <dbReference type="STRING" id="759272.G0SCD5"/>
    <dbReference type="GeneID" id="18259721"/>
    <dbReference type="KEGG" id="cthr:CTHT_0056830"/>
    <dbReference type="eggNOG" id="KOG3958">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038287_0_0_1"/>
    <dbReference type="OMA" id="YKFGDWE"/>
    <dbReference type="OrthoDB" id="4977at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028133">
        <property type="entry name" value="Dynamitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15346">
        <property type="entry name" value="DYNACTIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04912">
        <property type="entry name" value="Dynamitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="70"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="168"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="337"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS19061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="497" mass="53754" checksum="A09D998058A58EE7" modified="2011-10-19" version="1">MEDASCLCIRGAKTVGLRNRVYGTHNAKPLVAPVSCLAAVAHAARWCCIIAMATNRKYAALPDLDSAPDVYETPELTDDHSTIPPTTVQSPSDDEYDEDEDTSGISRSRLRIDEARSRFMPAVVDASNVDFSERLTSKRKSYKTTSRRRRILEDGTEELGDLSDEDGTVSLARRIARLKREIEEARQEYEKQKNAAATTAEEGKGVLPVEVEDQIDSLSKALDEISKLEEPLSPPGTILPAPKPPAPSTTDEGTVTATVTTGTTYTITYSPTYDQTHALAKAADFDRRLLILERALGIGSVDVPGLTPDNLPRAIIPLLEQLHKQITTLSEASVPTLDGITRRVRTLTQETENLEKARRSAKATQEAIASAGGNAAAAGTGTEGAGVSPETAEQMAKINALYGTLPTIESLAPLLPPLLDRLRSLRMIHAEAATAAETLARIEKRQAEMAAEIQQWREGLEKVEAAVREGDATMSKNVGVMEGWVKALEESMAKLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCH5</accession>
    <name>G0SCH5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein mS29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0057250</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS29 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696046.1">
        <property type="nucleotide sequence ID" value="XM_006695983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCH5"/>
    <dbReference type="STRING" id="759272.G0SCH5"/>
    <dbReference type="GeneID" id="18259763"/>
    <dbReference type="KEGG" id="cthr:CTHT_0057250"/>
    <dbReference type="eggNOG" id="KOG3928">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046315_1_0_1"/>
    <dbReference type="OMA" id="GLAHWMT"/>
    <dbReference type="OrthoDB" id="274828at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019368">
        <property type="entry name" value="Ribosomal_mS29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017082">
        <property type="entry name" value="Ribosomal_mS29_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10236">
        <property type="entry name" value="DAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036996">
        <property type="entry name" value="RSM23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS19101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="487" mass="53734" checksum="8F48FD3B76B33E84" modified="2011-10-19" version="1">MSASTCLRCCLVRPAPALSAASLPIRTATPLHQLRPAIQQVATFSTTPAAAKAAPKGNDPESSLKGHIRAGKRLVLRKFKKKNLDRGKPPLPGERKAYRKRIILSNDNALPVPWVTEMGPEDLLKKQNEAKVLSLPDDVVDQLRAIEAFKPTQNWKMFRKPSVLVRKETVDLVNRMQNAAGNRQTLKLVVTGDKVSGKSLLILEAQAHAFMNEWIVIHLPEGQDLTNAHTEYAPIPNTNPTQYMQPTYIMKLLQNIKKANEKVLMKLTTVTTHPELPQNITPGTPLITLAGACKEADYAWATFMAFWKELTHPAAQGRPPILFSLDGLAHIMRLSEYRSPAFELIHSHDLALVRLFVDCLSGHTPLPHGGAVLASTSGNNAPKTPSLDLALAQRLAEQAGKPAAEIPKRDPYFRGYDDRVEHALRNVQVLPLRGVSKLEARALMEYWAASGMYKEVVDERAVAAKWALAGSGLVGEMERAALLTMRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCI7</accession>
    <name>G0SCI7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0057380</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696058.1">
        <property type="nucleotide sequence ID" value="XM_006695995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCI7"/>
    <dbReference type="GeneID" id="18259776"/>
    <dbReference type="KEGG" id="cthr:CTHT_0057380"/>
    <dbReference type="eggNOG" id="ENOG502SB08">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115686_0_0_1"/>
    <dbReference type="OMA" id="GQGNIGH"/>
    <dbReference type="OrthoDB" id="2537432at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053203">
        <property type="entry name" value="Cisplatin_resist-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022024">
        <property type="entry name" value="DUF3602"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693:SF3">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12223">
        <property type="entry name" value="DUF3602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="133" mass="13864" checksum="CC016A37851F0E49" modified="2011-10-19" version="1">MSAPEVSHGRGGAGNINPDDTKYVDGEVVRIGAEGSHGDGAFSTGRGGAANIGDPGVKQTHRADKDLVPEAAIRPSSDNDYHTGRGGAGNVELVKTKTKESVKDAPQDSKDKPEAPLGLADRLKKKIYGVFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCN6</accession>
    <name>G0SCN6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0057870</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696107.1">
        <property type="nucleotide sequence ID" value="XM_006696044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCN6"/>
    <dbReference type="GeneID" id="18259825"/>
    <dbReference type="KEGG" id="cthr:CTHT_0057870"/>
    <dbReference type="eggNOG" id="ENOG502QR7D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023537_2_0_1"/>
    <dbReference type="OrthoDB" id="7771656at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008313">
        <property type="entry name" value="GH125"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047:SF2">
        <property type="entry name" value="DUF1237 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 157 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06824">
        <property type="entry name" value="Glyco_hydro_125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01149">
        <property type="entry name" value="DUF1237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS19162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="741" mass="80755" checksum="7599CD55E78A856A" modified="2011-10-19" version="1">MVVLCSMGNRRARFVGVALLMTVVVLWLGYQAQLAPTTLRQAPFEVRPQSPPTVEKPIGPQGQHGDHQGDVKVLPEKPTHDGGEKDAGMQKDSEEEELVITTAASTFTSASTATSVATSTSTSTALPTEDAVPSVNCTALRPPLPDSEGDGHFPYARPPPECRTFRLPELEAVLGRTSRRIEDRALIRLFRNSYSHTLDTMIRWRGYAHEKQPADSGQIAERPITDEELTFVVTREGSHVMYLRDSVAHIVPYERLLEPSKEPDSLASLWRGLINLQSRYILAAPLCDAFQPPDESNIAPQENPAPALSSTGSLPFDPKVVYDCRWELSNLASFLQLSAVYYYRTEDLEFFAKYSWVDAIAAIIDTAEAMRNGTVDIDGNSLVPAWPFNINGSEGLLDAIPPVKENGMIRSAFRPNGEPAVHQLVTPSNIMFAVYLEHAAAILEALSESVHGNDQKKAGKRETSRALDLATRMRALATGIGEGIKRDAVVKHPDFGEIFAYAVDGNGGVETPDDAANYPSLLAMSLWNFTLPERKEKTKQPQVVKSVKHVNGRDTGEEETQHENAIQEEKVKEEKPATTTFAIAAATASTATAKAVHITTSTSTSAHSTQQASTPESQYSYTAIYRSTRRFALSSSNTTSSSLSPSQNKLALAAISALTALDPMSGYNVTSSSSANEDDTNVEALAQRNDFLADQIQILLAESATGLVDGWVSGFVGELVIRIAEDEERRGRKGDVLGRLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCV3</accession>
    <name>G0SCV3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0058490</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696169.1">
        <property type="nucleotide sequence ID" value="XM_006696106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCV3"/>
    <dbReference type="STRING" id="759272.G0SCV3"/>
    <dbReference type="GeneID" id="18259887"/>
    <dbReference type="KEGG" id="cthr:CTHT_0058490"/>
    <dbReference type="eggNOG" id="KOG1273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121993_0_0_1"/>
    <dbReference type="OrthoDB" id="196858at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037850">
        <property type="entry name" value="RBBP5/Swd1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44040">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44040:SF1">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="124"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS19224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="170" mass="18913" checksum="A3EE44EA20BF16B1" modified="2011-10-19" version="1">MLEGPKEEQGVIEWHPHRPLLAACGLETGRINIWSVTSPQKWSALAPDFVEVEENVEYIEREDEFDIKPQEEIQKRRLDQEDEDIDVLAVDNGGGLGEELDEFRMPILFNLGESDSEEEFVNVSLGTLRRKSPGDQDDVDGELTGEDIGASKQTQSSGTGRAGRTGGRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0SD10</accession>
    <name>G0SD10_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Monooxygenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0050370</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695385.1">
        <property type="nucleotide sequence ID" value="XM_006695322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SD10"/>
    <dbReference type="STRING" id="759272.G0SD10"/>
    <dbReference type="GeneID" id="18259075"/>
    <dbReference type="KEGG" id="cthr:CTHT_0050370"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022195_9_2_1"/>
    <dbReference type="OMA" id="QAKWRNT"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS18440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="445" mass="49784" checksum="0D19730A3AD8A84D" modified="2011-10-19" version="1">MPATPAHRKTDSSKSRLGRQTLKSKSDLIHQMLEVLGRPVVLALLSALLGFLVHQLLSGPPTAKLKLPIVGAKKGDWFPFLQAQWRNTLNTKYALLLADTKYRDQPVLFPTFGASNLVLLPRSHAQFIVDQPDSILDIKIQTDESIQTKHTIVTPSLVHDPANVKLISVTLTSQIGNLVSDLADEIYESSGTTGAIQESTANFELLEIAMAYARAVPSAALILHFLWRPLRPLVAPLITLPIRLYTRRFVKLLLPEVEKRLVEYDSRRSSGRDNHEREPNDFLQWCIQHAKATGSPKEWKASLLAEKVLLLNFSAIHTSSLTITSAILELAASEQKYIDDLRIEIEKVLAEHGEERSDESAEYVKRAARAFVTTSIEYIAFGHGRHACPGRFFAAYELKLTLAHILLNYDIEIRGDRPKNSWYGLNRVQSVKATIRIKKGGLSHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDD4</accession>
    <name>G0SDD4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0051390</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695480.1">
        <property type="nucleotide sequence ID" value="XM_006695417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDD4"/>
    <dbReference type="GeneID" id="18259177"/>
    <dbReference type="KEGG" id="cthr:CTHT_0051390"/>
    <dbReference type="eggNOG" id="ENOG502RGVU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020424_1_0_1"/>
    <dbReference type="OMA" id="DVWMKDF"/>
    <dbReference type="OrthoDB" id="3340520at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010775">
        <property type="entry name" value="DUF1365"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33973">
        <property type="entry name" value="OS07G0153300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33973:SF4">
        <property type="entry name" value="OS07G0153300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07103">
        <property type="entry name" value="DUF1365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="547"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="612" mass="70752" checksum="EB08FEF9317E8904" modified="2011-10-19" version="1">MSGLRADIVNFSIRVLVSMPKYILGRRPAMEETSLQDGWGQVVFMPGLVFHWRLKPIEYQFMFPYLTVGIPVGREGDVAGILSVGSTGDARSWWQSIRNRFVNKSWFHVDARNYLARGRGELGLRGKLDLFLRERGADPERYPFAYLVTAPEMFGYQFNPVSFWFLYNSDKHLLATILEVNNTFGERHMYFLTEENTELSPTNLSSLFIQHFPKEFHVSPFNPRKGKYELNGCDPLWNSKGAEGVGLFMSISLHPSDPEDQTKLFTRVSCEERETIDPLTMSEREKFNFLLSWWWTGFLTIPRILRGAWDLYAQLGLPVWYKPEPLKGTLCREATSTERKLEAIFRRYLRHFVEHAPEAIKVRYVSGGITPHNEQEREEDVMFSRAARTRQAASGNPGVIQEVEFRVLDPSFYTRVLGYEDTFAALVLELDSQTIWVSDPELLGYHAAVANGPQQISCRCCAPFTAGPTTSYPRLSWRERMCLMLIRRLRDEPERIVRPMTDVQARVEGSKISKSGRNILDRVCGSHPSEMDEYVLRCELSQSRASYLFYAVGTLVNNRLVFFLFAIFYAIVWLLEMCVKWLPQVTRKVVWRVSNWQERVVFVVSRLKAAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDF4</accession>
    <name>G0SDF4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">OTU domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0051590</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695500.1">
        <property type="nucleotide sequence ID" value="XM_006695437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDF4"/>
    <dbReference type="STRING" id="759272.G0SDF4"/>
    <dbReference type="MEROPS" id="C85.008"/>
    <dbReference type="GeneID" id="18259197"/>
    <dbReference type="KEGG" id="cthr:CTHT_0051590"/>
    <dbReference type="eggNOG" id="KOG2606">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034963_2_0_1"/>
    <dbReference type="OMA" id="YELGAHY"/>
    <dbReference type="OrthoDB" id="415023at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22762">
        <property type="entry name" value="OTU_fungi_OTU2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049771">
        <property type="entry name" value="OTU2-like_OTU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF10">
        <property type="entry name" value="DEUBIQUITINASE OTUD6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="229"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS18555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="379" mass="42923" checksum="CA3D0BB08DCF1DB6" modified="2011-10-19" version="1">MGSKSKSNSKSQPTPPPGDSPSDLNTLLISPESNGAAPEPNGLPNGTEPTPTEGKETLEQMEARHIKEQRELQSRIANKKRNATKKTRNFINDECARMEWELRDRQQREMGELRRKLGLSEEAAEQEDELVDGIKEVKLDDEVPAPAPAPAQKPQPEPQQQQQQQQQQQQQQQQQQPKKKRNRHKERLARKQAQTEALMAQAEAEAAAMPDQRARERQAMQPVFDLHGLVEQPIEPDGHCMFAAIADALADQAIDLYKGVAPLPEDGEGKKEPPYKIVRRAAAERLVRHRDVFEGFVEGDFEEYVRKIRDTGEWGGQVELLALATAYGVEIKVVQEGRVETVSPMEGGDDEERETIWLAYYRHDYSLGEHYNSLRRKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDG0</accession>
    <name>G0SDG0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Membrane anchor Opy2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0051650</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695506.1">
        <property type="nucleotide sequence ID" value="XM_006695443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDG0"/>
    <dbReference type="STRING" id="759272.G0SDG0"/>
    <dbReference type="GeneID" id="18259203"/>
    <dbReference type="KEGG" id="cthr:CTHT_0051650"/>
    <dbReference type="eggNOG" id="ENOG502QV8M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030352_1_0_1"/>
    <dbReference type="OMA" id="TVPLDCT"/>
    <dbReference type="OrthoDB" id="2402916at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS18561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="47102" checksum="359AFFF8ECDF12AD" modified="2011-10-19" version="1">MAALLHPAAMPLYPRDEEPKCVLCDTSVQLVCPECTGNTQCQFITPTNCFECPRATCVPIEPIPAQPSQKSGANVGAIVGGVVGGLAALAIITYLVWRFCVRTRRQPLVQDETWEAEAEESPSGEKTYAQRRDYRASTHTVHSIASTVLTRASNIIQIAYIPGVTNRATANDSVLVPPVPPIPASHSAASSPNDDQHFFIPANLRDSTYSGLSSFSDRTSYARTSYAPRSSVASTIYGKNVVIAPAQTGMRAKPAMVSVRSARSNNSNKDDGSATPPVPAVDYDKYAIARPPSPANSTFSVGSTFLNNANTHTATPARAMVVRVGSVKKITQQARQPTTKPSSSSLSASSSDDVDILKSPTTVSGSTVRDSTCPTIIVDSPAVDFNEDQGPFSDPPPNSATPSTASLSAVIEEATRRASQRDSSMGSRAGPSRERSPFGDEHATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0SE70</accession>
    <name>G0SE70_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Centractin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Actin-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Actin-related protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0062690</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the actin family. ARP1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696578.1">
        <property type="nucleotide sequence ID" value="XM_006696515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SE70"/>
    <dbReference type="STRING" id="759272.G0SE70"/>
    <dbReference type="GeneID" id="18260307"/>
    <dbReference type="KEGG" id="cthr:CTHT_0062690"/>
    <dbReference type="eggNOG" id="KOG0676">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027965_0_2_1"/>
    <dbReference type="OMA" id="YTTWTGG"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10216">
        <property type="entry name" value="ASKHA_NBD_Arp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000007">
        <property type="entry name" value="Actin like 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000018">
        <property type="entry name" value="Actin-like protein (Centractin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00076361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00083222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS18247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="367" mass="40910" checksum="B205F7E44B3C2790" modified="2011-10-19" version="1">MADSLHNAPIVLDNGSGTIRAGFAGEDVPKCVFPSWVGRPKHLRVLAGALEGEVFIGQKAATELRGLLKINYPLEHGIVTDWDDMERIWSYVYDEGLKTLSEEHPVLLTEPPLNPRSNRDTAAQILFETFNVPALYCSIQAVLSLYASGRTTGVVLDSGDGVSHAVPVYQGFTVPNSIRRIDVGGRDVTEYLQTLLRKSGYVFHTSAEKEVVRLIKESVCYVAKDPRKEEKEWAAAKLDQGKIGAERFRAPEILFDPEIIGLEYPGVHQIVVDSINRTDLDLRKDLYSNIVLSGGSTLTKGFGDRLLSEVQRVAVKDMRIKIFAPPERKYSTWIGGSILAGLSTFRKMWVSIDDWHENPDIIHTKFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEA7</accession>
    <name>G0SEA7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0063080</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696615.1">
        <property type="nucleotide sequence ID" value="XM_006696552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEA7"/>
    <dbReference type="STRING" id="759272.G0SEA7"/>
    <dbReference type="GeneID" id="18260346"/>
    <dbReference type="KEGG" id="cthr:CTHT_0063080"/>
    <dbReference type="eggNOG" id="ENOG502RJJB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087384_0_0_1"/>
    <dbReference type="OMA" id="YFFRRYQ"/>
    <dbReference type="OrthoDB" id="3938544at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="177" mass="19581" checksum="26D435FE204BA973" modified="2011-10-19" version="1">MDSESDANLLLALDLSDSEPDEAAAPKGQTRAERSALSDAAFQALKETYKPKVENGELCKALLQTLPQHTKQQLPKPTAQALLHAVEELYFFRRYTKAIAFIHEVLGEEDNDANTNEDSKAQDESEGQSSGQGVKVDDETRKLLMYYKAKCRARAAELKSKAPPTIDGRKDRPVECA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEK7</accession>
    <name>G0SEK7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rhodanese-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0064090</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696715.1">
        <property type="nucleotide sequence ID" value="XM_006696652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEK7"/>
    <dbReference type="STRING" id="759272.G0SEK7"/>
    <dbReference type="GeneID" id="18260447"/>
    <dbReference type="KEGG" id="cthr:CTHT_0064090"/>
    <dbReference type="eggNOG" id="ENOG502S879">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107716_0_0_1"/>
    <dbReference type="OMA" id="TPWHEAF"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01443">
        <property type="entry name" value="Cdc25_Acr2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF50">
        <property type="entry name" value="REDUCTASE (ARC2), PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13400)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="50"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS18384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="167" mass="18287" checksum="27252777B008680F" modified="2011-10-19" version="1">MCDRQPAPAQPQEAAPSATPWWAAYPEPQSKPARISREEVLQMLKTKSLGERDFILVDVRRNDFEGGTVQGSINLPAQSLYPTIASVYTVFKAAGVKKAIFYCGSSSGRGPRSAAWLADHISRVGDTTMESLILEGGIKGWVNAGPEYVEWMDGYNAEVWKKLDGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEY5</accession>
    <name>G0SEY5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0060140</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696332.1">
        <property type="nucleotide sequence ID" value="XM_006696269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEY5"/>
    <dbReference type="STRING" id="759272.G0SEY5"/>
    <dbReference type="GeneID" id="18260052"/>
    <dbReference type="KEGG" id="cthr:CTHT_0060140"/>
    <dbReference type="eggNOG" id="ENOG502SB51">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072829_0_0_1"/>
    <dbReference type="OMA" id="WTDGTFQ"/>
    <dbReference type="OrthoDB" id="548474at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038966">
        <property type="entry name" value="TMA17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40422">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40422:SF1">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="235" mass="26317" checksum="72DD437BCF710AF6" modified="2011-10-19" version="1">MSADARPITPTRFAAALKELPTDALFTKLLELRNSIAHLDYSNEQLRPYAEGTARALDPNNPSSSQQSSQEDKCEPDQDCIDAIKENEAVIERMQERIRLLRTEVESRGLNWTDFESRARRAEEERRVVPEMDNTETIVVEHPNTQQQEAPTTNGTGPAVNGTGERSHPAWSDGTFQTGVIRDGVIEMHPPRAQQGGAGRQPGGSLSDEELRRRVEEQIRRLGVQEGDEEEGLYL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-03-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0SF32</accession>
    <name>UTP11_CHATD</name>
    <protein>
        <recommendedName>
            <fullName>U3 small nucleolar RNA-associated protein 11</fullName>
            <shortName>U3 snoRNA-associated protein 11</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">UTP11</name>
        <name type="ORF">CTHT_0060630</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. Interacts with snoRNA U3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UTP11 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696379.1">
        <property type="nucleotide sequence ID" value="XM_006696316.1"/>
    </dbReference>
    <dbReference type="PDB" id="5OQL">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="H=1-270"/>
    </dbReference>
    <dbReference type="PDB" id="6RXT">
        <property type="method" value="EM"/>
        <property type="resolution" value="7.00 A"/>
        <property type="chains" value="UK=1-270"/>
    </dbReference>
    <dbReference type="PDB" id="6RXU">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.50 A"/>
        <property type="chains" value="UK=1-270"/>
    </dbReference>
    <dbReference type="PDB" id="6RXV">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.00 A"/>
        <property type="chains" value="UK=1-270"/>
    </dbReference>
    <dbReference type="PDB" id="6RXX">
        <property type="method" value="EM"/>
        <property type="resolution" value="7.10 A"/>
        <property type="chains" value="UK=1-270"/>
    </dbReference>
    <dbReference type="PDB" id="6RXY">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.70 A"/>
        <property type="chains" value="UK=1-270"/>
    </dbReference>
    <dbReference type="PDB" id="6RXZ">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.40 A"/>
        <property type="chains" value="UK=1-270"/>
    </dbReference>
    <dbReference type="PDBsum" id="5OQL"/>
    <dbReference type="PDBsum" id="6RXT"/>
    <dbReference type="PDBsum" id="6RXU"/>
    <dbReference type="PDBsum" id="6RXV"/>
    <dbReference type="PDBsum" id="6RXX"/>
    <dbReference type="PDBsum" id="6RXY"/>
    <dbReference type="PDBsum" id="6RXZ"/>
    <dbReference type="AlphaFoldDB" id="G0SF32"/>
    <dbReference type="EMDB" id="EMD-10051"/>
    <dbReference type="EMDB" id="EMD-10052"/>
    <dbReference type="EMDB" id="EMD-10053"/>
    <dbReference type="EMDB" id="EMD-10054"/>
    <dbReference type="EMDB" id="EMD-10055"/>
    <dbReference type="EMDB" id="EMD-10056"/>
    <dbReference type="EMDB" id="EMD-3847"/>
    <dbReference type="SMR" id="G0SF32"/>
    <dbReference type="IntAct" id="G0SF32">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0SF32"/>
    <dbReference type="GeneID" id="18260101"/>
    <dbReference type="KEGG" id="cthr:CTHT_0060630"/>
    <dbReference type="eggNOG" id="KOG3237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061887_0_1_1"/>
    <dbReference type="OrthoDB" id="29058at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007144">
        <property type="entry name" value="SSU_processome_Utp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03998">
        <property type="entry name" value="Utp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015952">
        <property type="entry name" value="U3snoRNP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_5003409180" description="U3 small nucleolar RNA-associated protein 11">
        <location>
            <begin position="1"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="137"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P34247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="270" mass="31313" checksum="2D7279D68C2DC50D" modified="2016-03-16" version="2">MSSLRHAIQRRAHKERAQPLERQRLGILEKKKDYRLRARDYKKKQAVLKSLRQKAAERNEDEFYFGMMSRKGPGSALTRGKGFTGTVDGDRGNKALSVETVRLLKTQDLGYVRTMRNIAAKELKELEERYVLAGGADQPVEEFNSDEDEEESGSKQAKPKKIVFFEGVEERQQALEKQKADEEMKDYDEEEDGYDFDDEEEMTEKEKEERRKQLVLEKLARKVKAARKKLKALADAEYELELQQAKMAKTATSGGFTKSGRRIKVRERKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>G0SF52</accession>
    <name>G0SF52_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0060830</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696399.1">
        <property type="nucleotide sequence ID" value="XM_006696336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SF52"/>
    <dbReference type="GeneID" id="18260121"/>
    <dbReference type="KEGG" id="cthr:CTHT_0060830"/>
    <dbReference type="HOGENOM" id="CLU_2291370_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="101" mass="11335" checksum="21C22A4EC2CC2961" modified="2011-10-19" version="1">MHRENAVLDLAELRGPPLPENEWWESESDAELADLVLVAQPSDTSAPRHEDEDNDSGEYDEPCAPVLPPSRWTDKLTFWVIIVVGVSMAILKKSVDYAIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G0SF96</accession>
    <name>G0SF96_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0061270</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696443.1">
        <property type="nucleotide sequence ID" value="XM_006696380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SF96"/>
    <dbReference type="GeneID" id="18260165"/>
    <dbReference type="KEGG" id="cthr:CTHT_0061270"/>
    <dbReference type="eggNOG" id="ENOG502S9H1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120625_1_0_1"/>
    <dbReference type="OMA" id="YEAAEPY"/>
    <dbReference type="OrthoDB" id="2559326at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031833">
        <property type="entry name" value="DUF4748"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41800">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41800:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15932">
        <property type="entry name" value="DUF4748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS18112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="114" mass="12579" checksum="67732C1564E19224" modified="2011-10-19" version="1">MNTVSLAAFKPMTAGWGSLCVAGGVAYYFAKQSINADRQSRLEEQRKKREMIESLEKANSQPARTDFVASPSQEAVQDPAPTRHAPTTEGQRILEKSKYEAAVPFESPKGDRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFD3</accession>
    <name>G0SFD3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">5-hydroxyisourate hydrolase</fullName>
            <shortName evidence="7">HIU hydrolase</shortName>
            <shortName evidence="7">HIUHase</shortName>
            <ecNumber evidence="7">3.5.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0061640</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23736"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="ChEBI" id="CHEBI:58639"/>
            <dbReference type="EC" id="3.5.2.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.17" evidence="7"/>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696480.1">
        <property type="nucleotide sequence ID" value="XM_006696417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFD3"/>
    <dbReference type="STRING" id="759272.G0SFD3"/>
    <dbReference type="GeneID" id="18260202"/>
    <dbReference type="KEGG" id="cthr:CTHT_0061640"/>
    <dbReference type="eggNOG" id="KOG3006">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115536_0_1_1"/>
    <dbReference type="OMA" id="CSENQNY"/>
    <dbReference type="OrthoDB" id="10265230at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033971">
        <property type="term" value="F:hydroxyisourate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.180">
        <property type="entry name" value="Transthyretin/hydroxyisourate hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014306">
        <property type="entry name" value="Hydroxyisourate_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023418">
        <property type="entry name" value="Thyroxine_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023416">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036817">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023419">
        <property type="entry name" value="Transthyretin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02962">
        <property type="entry name" value="hdxy_isourate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395:SF7">
        <property type="entry name" value="5-HYDROXYISOURATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395">
        <property type="entry name" value="URICASE AND TRANSTHYRETIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00576">
        <property type="entry name" value="Transthyretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49472">
        <property type="entry name" value="Transthyretin (synonym: prealbumin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00768">
        <property type="entry name" value="TRANSTHYRETIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00769">
        <property type="entry name" value="TRANSTHYRETIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transthyretin/hydroxyisourate hydrolase" evidence="8">
        <location>
            <begin position="8"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS18149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="146" mass="15934" checksum="B609048D0A232658" modified="2011-10-19" version="1">MAEAKDRITCHVLDTTTGQPARNLRVQLHLSSPSANATPTPGPVIFESHTDDDGRIKTWLPYSGVNSSGDVPVYTLDDVLGGLENAPGGQNEMSQWTLKFDVAGYFGGLDKTFYPEVAVTFVVRKGQRYHVPLLLAPFGYTTYRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFQ4</accession>
    <name>G0SFQ4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pentatricopeptide repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0071720</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697437.1">
        <property type="nucleotide sequence ID" value="XM_006697374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFQ4"/>
    <dbReference type="STRING" id="759272.G0SFQ4"/>
    <dbReference type="GeneID" id="18261210"/>
    <dbReference type="KEGG" id="cthr:CTHT_0071720"/>
    <dbReference type="eggNOG" id="ENOG502SN7Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_378544_0_0_1"/>
    <dbReference type="OMA" id="LYYGHEM"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024319">
        <property type="entry name" value="ATPase_expression_mit"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12921">
        <property type="entry name" value="ATP13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS17819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="732" mass="83715" checksum="3F03616ABC9C40FE" modified="2011-10-19" version="1">MKAAFELSIPSELHTNHLIQEQANQIKGFRNPSSIIPDFGHCVEATDCTENSRSEMIRLSELLLWVGLQLSLTVEQEAGARSLGFVPGLSFADSQQLSTNDNLIPPSSYNSLDTGPHLAQRHAKHGLQLTEALKHPVRRLLYLTDIVRASRKAEDLEKLSMDALVQLPDTSFSELLRSLDPIESFSKELDPLDDINVEPGMWQRTPLGNEIDVWGVRKRYVHLLSQALAACQMRLESGKHLVLSDYVTLLRCAGAACDLKAMQTIWAMMSATGYRDIDPNGIYELIRARFLTDPLYTQHDLARFLVRPINLHMQKLWILGTKQRQYLRILGHNRIKRQRHYFGHNRNSLDHAEPLARILRKHIPPFRLYKHAVRKCYIVEERVLCALMVAWARSGSLQSIQQLILKRYWGVDVRRRSGCQAQVTGQAIAYAPDSPLRPTTRLLEAIVTSYCLNSEFATALQVVDVVSRCYNIPITKKIWFALLEWAYILNTKPVAREWKIVGRQFRYSKSIHPNSVQMVWNTMTADPYNVRPGLYQYQLLAKSLVGQGRAAEALDIMLELEPMYRHILTKLELSFSKHAVSMALGIDVAKTQLTWRRARARKHAALYHMQKICRDLLKVVCRGRTAEHATVRGVPQFIEAFRDLLPANIKYPIKTGIIELHYAQPIRRLEWAKMKFVQRPATTGDVRIGGKKKKLKVKTIEETRLGPAPHLSLHGFLTAEKPSWVLVQREFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFX3</accession>
    <name>G0SFX3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha-1,2-mannosyltransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0072470</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697506.1">
        <property type="nucleotide sequence ID" value="XM_006697443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFX3"/>
    <dbReference type="GeneID" id="18261285"/>
    <dbReference type="KEGG" id="cthr:CTHT_0072470"/>
    <dbReference type="eggNOG" id="KOG4472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024327_2_1_1"/>
    <dbReference type="OMA" id="YNDFFEM"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF2">
        <property type="entry name" value="MANNOSYLTRANSFERASE KTR5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="308"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS17888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="500" mass="57799" checksum="5FDC8F612262B02D" modified="2011-10-19" version="1">MDLFRRAGKFIPSVGPPLPIVEEKDKPRRLTWTSRLAYLRRPLRLRKGSSITVPLGVVILCPLAVIIFVLVLIVRHPNSGGRILIPAGAPPAISEKYDKVFVTGCLEPDTSKPRANAAFVVLARNKELDGVVQSLKSIERHFNRWYHYPYVFLNDGDFDDHFKETVRNYTSSSVEFGKVGPDMWGYPDWVDPKVAKEGIAKQGDNAIMYGGLESYHFMCRFYSGFFYKHPLLAKYEWYWRLEPEIKYFCDITYDPFLMMIEHNKTYGFTIAVKELRETVPNMFRYASAYKRMNNLTSQGLWEMFIEPKPEKPAEPQPPTGIPEEILRSEPGRNGPPEIDYEAMEGEKYNMCHFWSNFEIARLDFFRSKAYEDFFQMMDRSGGFWMERWGDAPIHSLALGALLSPKDIHYFRDFGYRHTTIQHCPANAPARQLPRPPYLEMTTLDEKKRIEEDQYWDEIDPPKENGVGCRCRCDTDIVDVEGKEGSCLAEWVQVAGGWASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2023-02-22" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>G0SG72</accession>
    <name>G0SG72_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0065280</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696829.1">
        <property type="nucleotide sequence ID" value="XM_006696766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SG72"/>
    <dbReference type="GeneID" id="18260566"/>
    <dbReference type="KEGG" id="cthr:CTHT_0065280"/>
    <dbReference type="HOGENOM" id="CLU_1288767_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="214" mass="23201" checksum="2564008B690EA8FE" modified="2011-10-19" version="1">MGTLPTLPKEVDGESGFLTASDVEPEEAGTTPGTGNGIVKGGVVVTADGSSTSPSGQGQIVHVNGLPVVVSKKMLKARRLATSLNIAHSQPRIRPPSIYNAVNPTIINPAVRSRASLLLYPGRPLTHTTHTRLSVKQLAAAKQRQKRKKKEEEAAEKARLAYAKRFDKKIRGDKVVQVDFRKRVRLWMKGVQAAIGEEGFGEVEFDGEGLPIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGP8</accession>
    <name>G0SGP8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0067120</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697005.1">
        <property type="nucleotide sequence ID" value="XM_006696942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGP8"/>
    <dbReference type="STRING" id="759272.G0SGP8"/>
    <dbReference type="GeneID" id="18260750"/>
    <dbReference type="KEGG" id="cthr:CTHT_0067120"/>
    <dbReference type="eggNOG" id="ENOG502SP89">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_379461_0_0_1"/>
    <dbReference type="OMA" id="MERPWAT"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF6">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="180"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="686"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="548"/>
        </location>
    </feature>
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        <location>
            <begin position="550"/>
            <end position="563"/>
        </location>
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        <location>
            <begin position="609"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="692"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="730" mass="79112" checksum="AE8270436D0154BF" modified="2011-10-19" version="1">MSDDPGPNAGASTRPDAGSTATDSVPLNSSTSPVLAVSDQTTQRSLAEDNASRNANANASASASASAPSSASTSTSNNSGLNRESHPPAQASSSRSTSAPVGNGIGSNTTSAEAGPSRPPLQTLADVMRAPSTVPPDVVVLESLPDDLERRRRQEDDEEPDPKADLWVSTYDGRFNSPIIPIHVGVPPNNATFYVHKHILLRCEYFEKALCGDFKESEAQAIDLPEEDPALFHFLVAYLYEGKYEPIKPLAAALAPDRKGKSKAAAPSPDSNSTAPADPATGPAAAAHGVRPEHIRRLARDNPAGAATLILDRLNNNANRPIPNYGGGAYYYPPVYPPAVAPPVPGRGGGCGTTVLLLELWCPDEEELETPFLLLLLLLLRRPPPPPPPPPVPPELYDPRYGGEQPGPGSGTGQGIRGEPQQPQEEEEKKEDPDRRSWTSLYTHHIRQYLLAHRFLLPSFQRAVARAIVLLLESLGSQAATMEVLQSCRTLYDGLPEGDPLVRMVFARVGFLQPWKNPGCGRGKQYQHQDGHHEDDLGKGKGKEKEYNGHAQSQGSLSANGHLNPNPDEHLDDDPESFLLTNPDIALGLLREMAARRDEDLIPPPIPAAPTGNTTTQGPGPAPGGPYPGGGPYGRAGREVRNYNGLYQHQQHQQQAPLPSMVRPLWVGEGGWPWGGEGEEGEWWWHHHHHQQQQQQRQQQQQQQHTAVSGRRRTERDRVVAGRLILDHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHK5</accession>
    <name>G0SHK5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FACT complex subunit POB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0070340</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2013" name="Nature" volume="499" first="111" last="114">
            <title>Structural basis of histone H2A-H2B recognition by the essential chaperone FACT.</title>
            <authorList>
                <person name="Hondele M."/>
                <person name="Stuwe T."/>
                <person name="Hassler M."/>
                <person name="Halbach F."/>
                <person name="Bowman A."/>
                <person name="Zhang E.T."/>
                <person name="Nijmeijer B."/>
                <person name="Kotthoff C."/>
                <person name="Rybin V."/>
                <person name="Amlacher S."/>
                <person name="Hurt E."/>
                <person name="Ladurner A.G."/>
            </authorList>
            <dbReference type="PubMed" id="23698368"/>
            <dbReference type="DOI" id="10.1038/nature12242"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 1-192</scope>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-16058545">
            <id>G0SHK5</id>
        </interactant>
        <interactant intactId="EBI-16058507">
            <id>G0SDN1</id>
            <label>CTHT_0052370</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>3</experiments>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the SSRP1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EGS17694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697312.1">
        <property type="nucleotide sequence ID" value="XM_006697249.1"/>
    </dbReference>
    <dbReference type="PDB" id="4KHB">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.40 A"/>
        <property type="chains" value="B/D/F/H=1-192"/>
    </dbReference>
    <dbReference type="PDBsum" id="4KHB"/>
    <dbReference type="AlphaFoldDB" id="G0SHK5"/>
    <dbReference type="SMR" id="G0SHK5"/>
    <dbReference type="DIP" id="DIP-60190N"/>
    <dbReference type="IntAct" id="G0SHK5">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0SHK5"/>
    <dbReference type="GeneID" id="18261072"/>
    <dbReference type="KEGG" id="cthr:CTHT_0070340"/>
    <dbReference type="eggNOG" id="KOG0526">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017374_3_0_1"/>
    <dbReference type="OMA" id="QVVTKIF"/>
    <dbReference type="OrthoDB" id="498543at2759"/>
    <dbReference type="EvolutionaryTrace" id="G0SHK5"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13230">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13231">
        <property type="entry name" value="PH2_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13229">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.220:FF:000003">
        <property type="entry name" value="FACT complex subunit POB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000146">
        <property type="entry name" value="FACT complex subunit POB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000310">
        <property type="entry name" value="FACT complex subunit POB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.150:FF:000001">
        <property type="entry name" value="Fact complex subunit ssrp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.220">
        <property type="entry name" value="Structure-specific recognition protein (SSRP1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050454">
        <property type="entry name" value="RTT106/SSRP1_HistChap/FACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048993">
        <property type="entry name" value="SSRP1-like_PH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000969">
        <property type="entry name" value="SSRP1/POB3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035417">
        <property type="entry name" value="SSRP1/POB3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024954">
        <property type="entry name" value="SSRP1_DD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038167">
        <property type="entry name" value="SSRP1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849:SF1">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21103">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17292">
        <property type="entry name" value="POB3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03531">
        <property type="entry name" value="SSrecog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00887">
        <property type="entry name" value="SSRCOGNITION"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="15" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="12">
        <location>
            <begin position="369"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="479"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="498"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="531"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS17694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="4KHB"/>
        </source>
    </evidence>
    <sequence length="571" mass="64305" checksum="4219418A5CD914CF" modified="2011-10-19" version="1">MAAIESFDHIYLDLSKEPGKCRFAENGLGWKPVGGGETFTLDVSNIGGAQWSRAARGYEVKILQRTSGVIQLDGFQQEDYERLAKIFKNWYSTNLENKEHSLRGWNWGKAEFGKAELTFNVQNRPAFEIPYSEIANTNLAGRNEIAVEFAPGDHGKSSQNGQVKSKKASASRDQLVEIRFYIPGTTTRKEAEGGEAGSDADEEEKNAVTLFYDTLIEKAEIGETAGDTIATFLDVLHLTPRGRFDIDMYDTSFRLRGKTYDYKIQYEAIKKFMVLPKPDDLHFMLCIGLDPPLRQGQTRYPFIVMQFKQDEEVTLDLNLSEEELNGKYKDRLQAHYEQPAHQVVTYIFKGLANKKVTAPAKDFTTHRGHYGIKCSIKASEGFLYCLEKAFMFVPKPATYISYEQTQSVTFSRVGGAVSTLSTFDITVHMKNGQGSSQFSNINREELKALEDFFKLKGLKVKNEIDEDANLLAAALRDDDMASSDEDVVGGKADRGSADEDEESVDEDFQAESESEVAEEYDSQHESSGSGSDEDDDDLDDDVVDDDEDEEEEEEEEEEEEEERPKKKKKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHR7</accession>
    <name>G0SHR7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP synthase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CTHT_0073120</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS16987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697569.1">
        <property type="nucleotide sequence ID" value="XM_006697506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHR7"/>
    <dbReference type="STRING" id="759272.G0SHR7"/>
    <dbReference type="GeneID" id="18261350"/>
    <dbReference type="KEGG" id="cthr:CTHT_0073120"/>
    <dbReference type="eggNOG" id="KOG1353">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010091_2_1_1"/>
    <dbReference type="OMA" id="INQRDNW"/>
    <dbReference type="OrthoDB" id="9805536at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18116">
        <property type="entry name" value="ATP-synt_F1_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1-ATPase_alpha_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.150.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004039">
        <property type="entry name" value="ATP synthase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="entry name" value="ATP synthase alpha/beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a_nt-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009884">
        <property type="entry name" value="PRK13343.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082:SF2">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039088">
        <property type="entry name" value="F_ATPase_subunit_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="15">
        <location>
            <begin position="67"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="13">
        <location>
            <begin position="190"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase alpha subunit C-terminal" evidence="14">
        <location>
            <begin position="420"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGS16987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="552" mass="59893" checksum="997958A412C53E4A" modified="2011-10-19" version="1">MFRNALRQSTRAVGALSASSRVLARNAAPVVAARQTRTYAEAKASPTEVSSILEQRIRGVQEEAGLAETGRVLSVGDGIARVYGMNNVQAEELVEFASGVKGMCMNLEAGQVGVVLFGSDRLVKEGEVVKRTGEIVDVPVGPELLGRVVDALGNPIDGKGPINYKEKRRAQLKAPGILPRRSVHEPVQTGLKSIDAMVPIGRGQRELIIGDRQTGKTAVALDAILNQKRWNNGTDEKKKLYCIYVAVGQKRSTVAQLVKTLEENDALKYSIVVAATASEAAPLQYIAPFTATAMGEWFRDNGKHALIIYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKMNDKHGGGSLTALPVIETQGGDVSAYIPTNVISITDGQIFLESELFYKGVRPAINVGLSVSRVGSAAQVKAMKQVAGSLKLFLAQYREVAAFAQFGSDLDAATKQTLNRGERLTELLKQKQYSPMAVNEMVPLIFAGVNGYLDAVPVNKILQWEADFLTHLKTNAPEIQAAIDKEGAISKETEAKLREVIESFTKSFLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHV7</accession>
    <name>G0SHV7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0073530</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697609.1">
        <property type="nucleotide sequence ID" value="XM_006697546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHV7"/>
    <dbReference type="GeneID" id="18261391"/>
    <dbReference type="KEGG" id="cthr:CTHT_0073530"/>
    <dbReference type="eggNOG" id="ENOG502SI2P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065434_0_0_1"/>
    <dbReference type="OMA" id="IASHNLY"/>
    <dbReference type="OrthoDB" id="5352400at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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    </evidence>
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        <source>
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    <sequence length="288" mass="33478" checksum="E267BEC4E4846D11" modified="2011-10-19" version="1">MKFTYRILRRPWRAKTPLYWSMLPELAGIIPLLILFTLLPRRKEFWSIGYEYRLNSNPAVVIFAMVNNQDSPKIPFVWSEASRNYNVAISILSLFVLLVKMIAIIMKVYYPLFGTTVGLSLTVVYAISIYGQAGPDYLDDRYPSPSPWYLRKSCELGRRFGKYDECIMARGALACTVFLLTVYLLQTAFAIWAMIPDKKLDEPRDPEDDLDDDESLFAISIRWEREKKRRRAAKGIDVEMTPTGQSPEEQKQGEEQQQQQQQQQQQQGEQLPPFTPRTQAFHKLSRYA</sequence>
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                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
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                <person name="Hurt E."/>
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            <dbReference type="EMBL" id="EGS17067.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
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            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
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                <person name="Kunze R."/>
                <person name="Devos D.P."/>
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    </evidence>
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        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
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                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
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            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="476" last="476">
            <title>High-resolution structures of a thermophilic eukaryotic 80S ribosome reveal atomistic details of translocation.</title>
            <authorList>
                <person name="Kisonaite M."/>
                <person name="Wild K."/>
                <person name="Lapouge K."/>
                <person name="Ruppert T."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="35079002"/>
            <dbReference type="DOI" id="10.1038/s41467-022-27967-9"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.90 ANGSTROMS) IN COMPLEX WITH MG(2+)</scope>
    </reference>
    <reference evidence="11 12 13" key="3">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e56910" last="e56910">
            <title>Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation during pre-60S biogenesis.</title>
            <authorList>
                <person name="Lau B."/>
                <person name="Huang Z."/>
                <person name="Kellner N."/>
                <person name="Niu S."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
                <person name="Cheng J."/>
            </authorList>
            <dbReference type="PubMed" id="37129998"/>
            <dbReference type="DOI" id="10.15252/embr.202356910"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <reference evidence="15 16 17" key="4">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e57984" last="e57984">
            <title>Structural insights into coordinating 5S RNP rotation with ITS2 pre-RNA processing during ribosome formation.</title>
            <authorList>
                <person name="Thoms M."/>
                <person name="Lau B."/>
                <person name="Cheng J."/>
                <person name="Fromm L."/>
                <person name="Denk T."/>
                <person name="Kellner N."/>
                <person name="Flemming D."/>
                <person name="Fischer P."/>
                <person name="Falquet L."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
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            <dbReference type="PubMed" id="37921038"/>
            <dbReference type="DOI" id="10.15252/embr.202357984"/>
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    </reference>
    <reference evidence="9 10" key="5">
        <citation type="journal article" date="2023" name="Nat. Struct. Mol. Biol." volume="30" first="670" last="677">
            <title>Structural inventory of cotranslational protein folding by the eukaryotic RAC complex.</title>
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                <person name="Kisonaite M."/>
                <person name="Wild K."/>
                <person name="Lapouge K."/>
                <person name="Gese G.V."/>
                <person name="Kellner N."/>
                <person name="Hurt E."/>
                <person name="Sinning I."/>
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            <dbReference type="DOI" id="10.1038/s41594-023-00973-1"/>
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    </reference>
    <reference evidence="14" key="6">
        <citation type="journal article" date="2024" name="Nat. Commun." volume="15" first="716" last="716">
            <title>Methionine aminopeptidase 2 and its autoproteolysis product have different binding sites on the ribosome.</title>
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                <person name="Klein M.A."/>
                <person name="Wild K."/>
                <person name="Kisonaite M."/>
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        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.10 ANGSTROMS)</scope>
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    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL14 family.</text>
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        <property type="resolution" value="2.90 A"/>
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        <property type="resolution" value="2.86 A"/>
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        <property type="resolution" value="2.91 A"/>
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        <property type="chains" value="LV=1-139"/>
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    <dbReference type="AlphaFoldDB" id="G0SI44"/>
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    <dbReference type="SMR" id="G0SI44"/>
    <dbReference type="STRING" id="759272.G0SI44"/>
    <dbReference type="GeneID" id="18261482"/>
    <dbReference type="KEGG" id="cthr:CTHT_0074440"/>
    <dbReference type="eggNOG" id="KOG0901">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095071_3_0_1"/>
    <dbReference type="OMA" id="IRQSKPW"/>
    <dbReference type="OrthoDB" id="407959at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.150.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
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    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_uL14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7 8 9" id="KW-0002">3D-structure</keyword>
    <keyword evidence="7 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS17114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="7OLC"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="7OLD"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="7Z3N"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="7Z3O"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="8I9R"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="8I9T"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="8I9V"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="8OO0"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="8PV1"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="8PV2"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PDB" id="8PV3"/>
        </source>
    </evidence>
    <sequence length="139" mass="14650" checksum="10EF91394B01484A" modified="2011-10-19" version="1">MAKQKRGAPGGKLKMTLGLPVGAIMNCADNSGARNLYIIAVKGAGARLNRLPAGGVGDMVMATVKKGKPELRKKVHPAVIVRQAKPWKRFDGVFLYFEDNAGVIVNPKGEMKGSAITGPVGKEAAELWPRIASNAGVVM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>C0HMA2</accession>
    <name>DAD4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DASH complex subunit DAD4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Outer kinetochore protein DAD4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">DAD4</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2018" name="Science" volume="360" first="552" last="558">
            <title>Structure of the DASH/Dam1 complex shows its role at the yeast kinetochore-microtubule interface.</title>
            <authorList>
                <person name="Jenni S."/>
                <person name="Harrison S.C."/>
            </authorList>
            <dbReference type="PubMed" id="29724956"/>
            <dbReference type="DOI" id="10.1126/science.aar6436"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (4.50 ANGSTROMS)</scope>
        <scope>IDENTIFICATION IN THE DASH COMPLEX</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the DASH complex that connects microtubules with kinetochores and couples microtubule depolymerisation to chromosome movement; it is involved in retrieving kinetochores to the spindle poles before their re-orientation on the spindle in early mitosis and allows microtubule depolymerization to pull chromosomes apart and resist detachment during anaphase. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and microtubules. Kinetochores also serve as an input point for the spindle assembly checkpoint, which delays anaphase until all chromosomes have bioriented on the mitotic spindle.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 2 3">Component of the DASH complex consisting of ASK1, DAD1, DAD2, DAD3, DAD4, DAM1, DUO1, HSK3, SPC19 and SPC34, with a stoichiometry of one copy of each subunit per complex (PubMed:29724956). Multiple DASH complexes oligomerize to form a ring that encircles spindle microtubules and organizes the rod-like NDC80 complexes of the outer kinetochore (PubMed:29724956). DASH complex oligomerization strengthens microtubule attachments (By similarity). On cytoplasmic microtubules, DASH complexes appear to form patches instead of rings.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DASH complex DAD4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PDB" id="6CFZ">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.50 A"/>
        <property type="chains" value="E=1-63"/>
    </dbReference>
    <dbReference type="PDBsum" id="6CFZ"/>
    <dbReference type="SMR" id="C0HMA2"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013959">
        <property type="entry name" value="DASH_Dad4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28222">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28222:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08650">
        <property type="entry name" value="DASH_Dad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0137">Centromere</keyword>
    <keyword id="KW-0158">Chromosome</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0206">Cytoskeleton</keyword>
    <keyword id="KW-0995">Kinetochore</keyword>
    <keyword id="KW-0493">Microtubule</keyword>
    <keyword id="KW-0498">Mitosis</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000459473" description="DASH complex subunit DAD4">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P69851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q50HP4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="29724956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="29724956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="7">
        <source>
            <dbReference type="PDB" id="6CFZ"/>
        </source>
    </evidence>
    <sequence length="72" mass="8393" checksum="1B8FEB5904FE8763" modified="2024-01-24" version="1">MESPHEHQQNLLLSRIITNVEKLNEAIMVMNKTLQEINIQNMNIELVAQMFKNYQSNVLFHLEATDNLKDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0RXY6</accession>
    <name>G0RXY6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="2">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0004740</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="2"/>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691014.1">
        <property type="nucleotide sequence ID" value="XM_006690951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RXY6"/>
    <dbReference type="STRING" id="759272.G0RXY6"/>
    <dbReference type="GeneID" id="18254512"/>
    <dbReference type="KEGG" id="cthr:CTHT_0004740"/>
    <dbReference type="eggNOG" id="KOG1448">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033546_0_1_1"/>
    <dbReference type="OMA" id="MMLVGDI"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000063">
        <property type="entry name" value="Phosphoribosylpyrophosphate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000056">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF36">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="11">
        <location>
            <begin position="6"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS23772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="435" mass="47192" checksum="AEC456786B7B0821" modified="2011-10-19" version="1">MVRNIVVLGGNSHPELTKSVCEILGIPPCNRILTKFSSGESRCEIQDSVRGKDVYIIQTGFGGNGSRLNDHFMDLCIMISACKTGSARRVTAVLPLFPYSRQPDLPYKKTGAPLYKAQSESDKKNYTFDSVPVTPGPGTAQSTGLSNGADLLKSALTNGNGHANGDAYFGGQSIYTTHDYENASHVGAFQAKPGYKQWVAQAGTLVANLLTCAGADHVITMDLHDPQVQGFFDVPVDNLYGRPLLKRYIQTHIPNYKDAVIISPDAGGAKRATAIADSMGIDFALIHKVRSPPLAPIQAYQHPLFFTQERRPTKITDRQNASMMLVGNVTGRVCILIDDLVDTGNTITRAAKLLKKEGATTIYALITHGVFSGDAINRIKASAIDKIVVTNSVPQDEHKDLLGNKLDVLDISHIFAEAIRRVHHGESISVLFNHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYJ9</accession>
    <name>G0RYJ9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA splicing factor (Pad-1)-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0006960</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691227.1">
        <property type="nucleotide sequence ID" value="XM_006691164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYJ9"/>
    <dbReference type="STRING" id="759272.G0RYJ9"/>
    <dbReference type="GeneID" id="18254734"/>
    <dbReference type="KEGG" id="cthr:CTHT_0006960"/>
    <dbReference type="eggNOG" id="KOG0147">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020551_4_1_1"/>
    <dbReference type="OMA" id="GRDNDKG"/>
    <dbReference type="OrthoDB" id="5411533at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12283">
        <property type="entry name" value="RRM1_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12284">
        <property type="entry name" value="RRM2_RBM23_RBM39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12285">
        <property type="entry name" value="RRM3_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000291">
        <property type="entry name" value="CC1-like family splicing factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000354">
        <property type="entry name" value="RNA splicing factor Pad-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029123">
        <property type="entry name" value="RBM39_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006509">
        <property type="entry name" value="RBM39_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01622">
        <property type="entry name" value="SF-CC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48036">
        <property type="entry name" value="SPLICING FACTOR (PAD-1), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G15810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15519">
        <property type="entry name" value="RBM39linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="230"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="327"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="424"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="159"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS23985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="594" mass="67837" checksum="0AB8D7F7939E34DC" modified="2011-10-19" version="1">MSGLDVEALLDSTASSKEQNSKATANGDSPQNGSRSEHTDRERGRDDRSRDDTRGRSRDRSYSRSRDRDRDRDRSRSPSRDTRDRDRDRRRRDRSPARYRGSSSGRDTPRSEAGSHKSRRRSRSRESGRHSRRHRDGDYYRGSTRGAGRSRSRSPTRYYRPDRDRDRDARDRGDRYRRRDDDRDHDRDRDRDRERDRERDRERDRDRRDRARRRSTPREPSPTNDERDRRTVFVQQLAARLRTRELKEFFEKAGPVAEAQIVKDRVSNRSKGVGYVEFKSEESVAAALQLTGQKLLGIPIIVQPTEAEKNRQARTTSGHHPNSVPFHRLYVGNIHFSITETDLQHVFEPFGELEFVQLQKDENGRSRGYGFVQFRDAANAREALEKMNGFDLAGRPIRVGLGNDKFTPESTANLLRGFPGQGSAFSGAGGRGPPASTFDRAGGRDSDKVSGASALDDTDVAGVNFNNYSRDALMRKLARTDEPAPERQILKPKTVETKPLPVNVNMASRQQGEDWIKELEDEVRQEAEEKYGHVVHIAVDPNSNGDIYLKFDKVQGGENAIKGLNGRYFDGRMITAAPVVDAVYSSLFSRAKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYM6</accession>
    <name>G0RYM6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0007230</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAK10 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS24012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691254.1">
        <property type="nucleotide sequence ID" value="XM_006691191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYM6"/>
    <dbReference type="STRING" id="759272.G0RYM6"/>
    <dbReference type="GeneID" id="18254761"/>
    <dbReference type="KEGG" id="cthr:CTHT_0007230"/>
    <dbReference type="eggNOG" id="KOG2343">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011757_0_0_1"/>
    <dbReference type="OMA" id="QMEWIVQ"/>
    <dbReference type="OrthoDB" id="269405at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057983">
        <property type="entry name" value="NAA35-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007244">
        <property type="entry name" value="Naa35_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057982">
        <property type="entry name" value="TPR_NAA35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373">
        <property type="entry name" value="GLUCOSE REPRESSIBLE PROTEIN MAK10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373:SF0">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 35, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04112">
        <property type="entry name" value="Mak10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25789">
        <property type="entry name" value="TPR_NAA35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAA35-like N-terminal" evidence="5">
        <location>
            <begin position="77"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="NAA35-like TPR repeats" evidence="6">
        <location>
            <begin position="347"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS24012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="784" mass="88656" checksum="DA831878421F3A68" modified="2011-10-19" version="1">MTTFQSRFPDSPSDDELSMSRGFADLDLNHPAAHMDPAQYYQQPPPPPPPPPLISSEGIVAFDITREFRDAAAALEPGELVKDGYFTLFESVGALEIMDPKMDSGCLAPGESLDEEYDVTRPLEPNEVLGVIDQLLCLEMAWHLGYPLSQTVFTSVYIDKILDPAPTTLEQADFFRDRPGEQQLMHRVLRAYCLGLIKTCWLEEDFVTNTYNRPLLDTIPSSVIHTELLSAREALLHSLSAIGPDLTNALVSRLDMRLNFLYAVELMEQRSADPEVLRQPWVKLQEIWKEVGRTQGMGKRVAEAFSTKIQRRLASTMPPRPIVQLGGEEMVRLFGQLWEDGERVVGVLGWRDAQSLLNFILTYHSPLLFPRTLLQYFLFHDMVILGRLSIRQLLDDDLSTLVLPSSPLLDRANDAVEHPHHPRYQLAQTMELFRQRVAQSYLDVFRTWCQNRCRVRRTMVHAIADWEAVQAEAEEFDGRLMGVLLEQAVKYPPMSGEEGHAMPLSSWAYHYKLRLMQWTVLLGFELEIYQAAELPGMYWYLAYLADHHVRHLSGTQSSVDRQLTANPPLTPTQQKLAARCKSFLRLALLEASATYALADSLSCLWTAIERMGLLPDIKRKQNFPYGGDELRYELRMRPWASVSLPALPTYEEFVESVKRADVSTAELLEMAVRGAKRAEKGLETLAGWGTFSGAQDGGKGGGKESYEWGPFCLPGWGTESWRENVRKWMSAAVAAGTVVEGLKGVGNGEDKEWVKVEVPKVEERYHSWWVVPGLSKEGERGQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYQ9</accession>
    <name>G0RYQ9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Striatin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0007560</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat striatin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS24045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691287.1">
        <property type="nucleotide sequence ID" value="XM_006691224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYQ9"/>
    <dbReference type="STRING" id="759272.G0RYQ9"/>
    <dbReference type="GeneID" id="18254794"/>
    <dbReference type="KEGG" id="cthr:CTHT_0007560"/>
    <dbReference type="eggNOG" id="KOG0642">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009046_0_0_1"/>
    <dbReference type="OMA" id="SKCSQEV"/>
    <dbReference type="OrthoDB" id="727118at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013258">
        <property type="entry name" value="Striatin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051488">
        <property type="entry name" value="WD_repeat_striatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653:SF0">
        <property type="entry name" value="CONNECTOR OF KINASE TO AP-1, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653">
        <property type="entry name" value="STRIATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08232">
        <property type="entry name" value="Striatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Striatin N-terminal" evidence="9">
        <location>
            <begin position="34"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="557"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="756"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="232"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="577"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="701"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="311"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="374"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="598"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS24045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="835" mass="90126" checksum="5F65BF0B5BD6FEF3" modified="2011-10-19" version="1">MGTNGASGMGAGAHDQTGMMGGNNPSHPPTTEYTLQGVMRFLQSEWHRHERERNAWEIERQEMKHRIAQLEGQARRADATQRALKKYVAILEKKVKEQAALLKSGKAPEPEPNPDRAVLLREKLRPSAEKLATGTSDPASLEAALADEEASRKELKEFLDQCQAEFTYLMITPANPPPPKGSPPLPVLEDFRETEGFGQQILDPQQQQQQHYQQQNMQPQQNHIREFGQNRAAPIPTNQSPAPPGPGNFHVKHQDPQSVSMTRSHSEHPSSSYGTTAEWAAQMQMQAPAPGKPMPEPLHELPSQLTKHHGRGEEKGPASATDKRAPETDSWDFNDSSFPETAAPQPHQQVSSRPDTDVFPAADSIPKSPSRGSLPHRRKNSSSSRRRSSEHDLSLLPLSSKPESTAFKLKFHLRGHLDTIRTVIFSGGGSPGEPEICTGGDDGMIKRFHIPDRHGSHMGSGSSDFDVTADFTHRGHTGSVLSLAAWSPSPNFLTGGRAQGDGWIFSGGQDATIRVWERGRVDPKATIDGHTDAVWALCILPTTLGAIFGQSSTYGPPDRILLVSGAADGTVKVWAVTAPPQLTSPQPSTGRRPGGRTRGNSMSSGSAFPSSPQPTTASTTPFHYTLIHTILRQNSTASPTCITPLSPNGETFVVSYTDAAIIVYDTRTGEEIGNMASLETYDGSMGTSVNAVVATTVGLDQTPHQGMSEEDSAGGGPTGSSRAMAGSGVEGVIISGHEDYYIRFFDANSGQCTYNMVAHPAAISSLSLSPDGRELVSAGHDASLRFWSLEKRSCIQEITSHRVMRGEGICTVVWSQDGRWVVSGGGDGVVKVFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYT1</accession>
    <name>G0RYT1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0007790</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS24067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691309.1">
        <property type="nucleotide sequence ID" value="XM_006691246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYT1"/>
    <dbReference type="GeneID" id="18254817"/>
    <dbReference type="KEGG" id="cthr:CTHT_0007790"/>
    <dbReference type="eggNOG" id="ENOG502T4FC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_177972_2_0_1"/>
    <dbReference type="OrthoDB" id="5188169at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS24067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="100" mass="11074" checksum="03C64E0FB5A7B10F" modified="2011-10-19" version="1">MSMIAAFRPTLRLAANVNNSVAVPASKSAANKLVGGVVTLGCVSAVVGYIGSQLRRESNVMDRMFEKQNTPEVIRRRNERLLVDTEGDPRKSLFNILNWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZE5</accession>
    <name>G0RZE5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0002680</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690815.1">
        <property type="nucleotide sequence ID" value="XM_006690752.1"/>
    </dbReference>
    <dbReference type="GeneID" id="18254306"/>
    <dbReference type="KEGG" id="cthr:CTHT_0002680"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000263_0_0_1"/>
    <dbReference type="OMA" id="WGQKATF"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000050">
        <property type="entry name" value="Related to histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000010">
        <property type="entry name" value="Sensor histidine kinase RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF74">
        <property type="entry name" value="HISTIDINE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAC" evidence="11">
        <location>
            <begin position="819"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="10">
        <location>
            <begin position="878"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="11">
        <location>
            <begin position="990"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="1055"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="1625"/>
            <end position="1791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="272"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="461"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="574"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="650"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1286"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1344"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1700"/>
            <end position="1746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="310"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="584"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1344"/>
            <end position="1358"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1359"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1714"/>
            <end position="1725"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="1677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
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            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS23573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1791" mass="197267" checksum="25245047947C05EB" modified="2011-10-19" version="1">MTTTPRHSEGSKEEPIQTNKDADGDSKRDPQAPTSLIKITGSGKKSNNTHLLVHGISGRHIENHSETEPRDAQRPEPTTASTDSEQTIQGSQQQQQQQQQQQQQQQQQQQQQQQPHSHLSKGHDVVVTSISTPSSATPFLPSGLAQPTTQQHSVQSPNLYDLTLMLSSEPGLDAWWNSVVQIMSQSQKTKEGRKQQSTQRQDFRIDPVYPQVANQAFRQRLQIKVPGNKMGRTRGKVFSTLQPLDYESDPLIDHNGVLRILERGRAVALTRTYPYPNQEPAQAKSSDSRPASAPKPAEMVRKKSKRLRSESLSGKLSSFLSSATPSPGSSNRPSSSRSLRPCEGRSTFASRLGEESPPAVPTPKYEEYEQAPPSPWSQSPAPSPAVRPEPAENPFFTDAMVDEDTFNPASASPDYSKMVPPEAIGIDHNTWTVLHIPLTHVLLSKPNPSFRLNPKLMEQKLARKSGSVPTSISTEPSPGRPPKEKQAPIAIISILSPLIPYPSHLRHSLEHLSPHLATTFSLARHYTNLETELIGLQKRRPQASGFRTLEPDGRPLSDPNAALTFLAERNLAVEEEGTPRDSIAGSTTSPSDHSGLSHSAICSPVATPGREAKVGRLLLSPSRAGVEGYFGRPPRSVPPEFCGQRARRYSDGFERPPSLDALESSSGQAFRQPEDVQPAIPRRLKEKLKQPTAETPRRHTKLHSCGADFSSTFQSLPSISTMFSFQPTGAPSSSTTSRQADLTPPSDKLKSLILDFLPVHVFVALPQTGEIVWVNSRFLSYRGLTSAQLALDPWGSIHPDDRDEYLRAWNHSVRTGEQFSRTVRIRRFDGAYRWFYARAVASRDKRGVIMQFLGSYMDIHDQHIAELRAARQEEIEASEAKHRLLANLIPQIIFTATEDEGVTFANEQWLSYTGQSFQDSLGLGFMDFVHPDDLAKCKLPAVIRKGKKKGDQEGEDDEASTPELASPSLTELTKKGVIRVSRDSSGRLSYTTEIRLRAKSGEYRWHLVRCVEIDNVDFGNGVSSYFGSATDINDLKLLETKLKEAMDSKSRFLSNMSHEIRTPLIGISGMVSFLQDTTLNEEQRDYTNTIQTSASSLLMIINDILDLSKVDAGMMKLTYEWFHTRSLIEDVNDLVSTMAVAKRLELNYVVEEDVPDWVKGDRVRIRQVLLNVIGNAIKFTNKGEVFSRCRVFVPSREDNVRLHPNEIMLEFSVIDTGRGFTKAEAELIFKPFSQIDGSSTRQHGGSGLGLVISRQLVELHGGKMEGTAVPGKGSTFTFTAKFGLPTETDHPDEEALMPQPTSATTPGETPMPQSPVELVDVYHAVATAVDQAVAMSPEMMSCSASSELSGSGSCSSSSVPTVATTGRSSVSTAPYPAAVNAASLAGLSQAEKASGQELSGMKLQIPRPQAQQGTTEGGKAVVGHTLPSRYSILIICPQTHSREATVKHIEMTLPKGVPHQITAVGSVDEAEKLLETGKGKGPQYTHIVINLPSPEEILALMDIVARVEDETDDANKAFILILSDSVQRQAVAKLAIGTRHEAALLSYATPSAIPANQLSQPPHRVTYIYKPVKPARFAAVFDPGPTSTEHARFYDHTKSTAQRLVEDQRQSYVDMERRLGGKGYRVLLVEDNPVNQKVLSKYLKRVGVEVEVASDGEECMQLVLGKGWGYYSLILCDLHMPRKDGYQACREIRAWEAKMRQEQEQQHAAQAQQSGDDTQHCTPPETTAVKPAPSLESKQPQSSKSRELPIIALSANVMSDVHDKCVAAGFSDYITKPVDFIDLSRALAKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZR6</accession>
    <name>G0RZR6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hydrolase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0003910</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690936.1">
        <property type="nucleotide sequence ID" value="XM_006690873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZR6"/>
    <dbReference type="STRING" id="759272.G0RZR6"/>
    <dbReference type="GeneID" id="18254429"/>
    <dbReference type="KEGG" id="cthr:CTHT_0003910"/>
    <dbReference type="eggNOG" id="KOG2024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009935_3_1_1"/>
    <dbReference type="OMA" id="PQCGSPF"/>
    <dbReference type="OrthoDB" id="408320at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051913">
        <property type="entry name" value="GH2_Domain-Containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732:SF2">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolases family 2 sugar binding" evidence="6">
        <location>
            <begin position="42"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="4">
        <location>
            <begin position="160"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 catalytic" evidence="5">
        <location>
            <begin position="283"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS23694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="549" mass="61996" checksum="DBAFB95E877C82A2" modified="2011-10-19" version="1">MDGPAKGPDAINALPQLPLAKEVRIPSCIESGISGIMTMGVTHMWFGTTFTIPPHWKDGRRVLLNFEAVDYEATVYVNGANVGFNRGGFSHFTLDITKHVVPNKINQLHVFVFDPTDDQSIPQGKQTKRLSHIFYTPCTGIWQTVWLETVPKNYVTGLDLSADMNGIVTGIVYSHNNSSTPIEISVTNSKGDIVAIHRHVSDQLFKFTVASPQLWSPESPTLYNIAVTMGSDRVESYTGFRTISTGVVNGVKRPLLNGKFVFLFGPLDQGYWPDGIYTPPTYEAMIYDLQVIKRLGMNLVRKHIKVEPALFYHACDVLGLLVMQDMPSMRVYTNARPTNSEQAEFERQLEVMVNQHKNYPSIFTWVIYNEGWGQITDYHPEFHLTDRIRQLDPTRLINSVTGWHDHGAGDYHDNHHYAEPQCGTPFHSLPSTPYDPKRIGFQGEFGGIGHRPADANLWPIPDAVNTINQTYELHGTIESYHYRAHVLLELLRQQVEQYACSGAVYTQTTDVEGEVNGLLTYDRRVLRINETQWKEDIKALYAAAKKRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0J6</accession>
    <name>G0S0J6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="3">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0010250</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="3"/>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691548.1">
        <property type="nucleotide sequence ID" value="XM_006691485.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S0J6"/>
    <dbReference type="GeneID" id="18255063"/>
    <dbReference type="KEGG" id="cthr:CTHT_0010250"/>
    <dbReference type="eggNOG" id="KOG0902">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000893_1_0_1"/>
    <dbReference type="OMA" id="TIEVWQS"/>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05167">
        <property type="entry name" value="PI4Kc_III_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.70:FF:000011">
        <property type="entry name" value="Phosphatidylinositol 4-kinase alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000022">
        <property type="entry name" value="Phosphatidylinositol 4-kinase stt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000014">
        <property type="entry name" value="Phosphatidylinositol 4-kinase STT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045495">
        <property type="entry name" value="PI4K_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF15">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19274">
        <property type="entry name" value="PI4K_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIK helical" evidence="9">
        <location>
            <begin position="1293"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="8">
        <location>
            <begin position="1572"/>
            <end position="1839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS23357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1855" mass="206507" checksum="F2B1A05FB292B903" modified="2011-10-19" version="1">MCCSFEWKTIREYEVLIALCRAAPAVQASQNAQKLARHLIPYLMDAHVQAFAHSPFFRKIEPCPTESLSYHVTAALLSLGLNHADVQQTVSDNISSFLNICAHATESVSPADDGSDPDAVEDAIRTATLAVALLGFLDAACAQATFWRTGGRLGLVMRVRDLLSQPFLVAVEAAFSTLRNAHSHDRLTKDWKRWVRHYDEIGRPLGAMLLQRSFMRLLVAATSLLVAEEDALRSHHILDIIMSGNGLRRPLTSRSAEADFRSVELYATVAIDQMNYLESSADFDSLSPAKQRLASSVKACALISYLNSCTLNEEAADAEVLMAWLEDAITDGAGMADDELATVVLKSMALLCRLSPAYATNISRLLPRFIVQSGAKSQVVAVASKCLAFVLQVLSKDAVITTLYTLGNVLSPVDDRRLGNGVGADSVTDGHDISRVYTGRPSTGSSISLQISGEEESLVVQGNVVQAICEIATACQDEKITGLAQSILAQKMVKLSSPVDARLITGAAALALNGGPSEFRNLLKRLAAVSHDALLENKDGVLQAVMQARNYISANISQESPLFDIYLEYLLDGIISQGDAHSNQSHHARDSDVELAAREIAQLLPPLAILMAANPAAFDELSDDDTRSMLRDAWFNVVVHGFNLLTERGKQNLTHLRLMAIHSPPLISENRSEQDESDIELNPILRRGESSESENAQKKILMELLPTRGSEIKGLSYRKTIFLQAAYLVETLRADAGDCTKALIYFLEPGLRRGDVSRIMDAIMHAVVDRYLAKTIGAANPPFSSQFAATQLAKIFSSCCHRIERVQQAAFACADRLIEAIPSALCQRSSLFSLLELLSLMWESCLEAETDRYEPRTTFKSPRGDVVLELSDDYQFRQLTLESLHKKAKAWVTSAINIAPSDVKGLLQTYLSEFEDESSYGHLSLGRSFAVEIGSTIPSTDQRLVSLERLGDCLINTASDFMAQYTTRQEYRYSDALLDHSLEWPTSKRIDRKPSLFTSSETECADAVSALACLEKRVLSRTATPFPHVRDILRRAAALLCRSKHNECSITRYLVSIPFGLFTKQSIKLGISLWLGIMNENPRLESRILAEIVQGWELSIRKKKGLFSPSIANPDPFFLKQEFAPSDSAALAKRKQVVHDMLTPHSRLLQFLSSHYNATRLGNPDTHRMFLRLVEVTLQAIKTSTPHPIAREIRFQVILFGLRVLKTSSTMSLAAQYRLKDQILSAALSWFNTPPRWSFGSNILQLKTELRLMEDITAALAETAHIGSLPTGPAKSLATKEKLLLLLLESEQSRLHVWVRPLDSGRFQSTFYHGSKDGPSEAAICPLVRSAWTETKAAKEPEAIPILIDGGLPDDVNFQLKYLLFWAPVNPITAVTLFLPTYRNHPYLIQYAMRALESHSVDVTFFYVPQIVQTLRYDALGYVERYILETAQFSQLFAHQIIWNMKANAYRDDDCQIPDPIKPTLDKVMAHMIDSFSEADREFYEREFAFFDEVTSISGKLKPLIKRSKPEKKQKIEEELRKIKVEVGVYLPSNPDGVVVGIDRKSGKPLQSHAKAPFMATFRIRKNKGNVEGSEEMIEAGDVDNKVVTQANTIEVWQSAIFKVGDDCRQDVLALQMIAAFRGIFQSVGLDVYVFPYRVTATAPGCGVIDVLPNAISRDMLGREAVNGLYDYFVSKYGNEDSLRFQQARNNFVKSMAAYSVISFLLQFKDRHNGNIMIDDAGHILHIDFGFCFDIAPGGIKFERAPFKLTSEMVAVMGGSPDHQAFKWFEELCVKAFLASRQYSEKLSQIVLLMMDSGLPCFKPESVKHFKERFVLDKSEREAAEFMRGLIKRSYGSYSTGIYDQFQLLTNGIPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0U0</accession>
    <name>G0S0U0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0011220</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 26 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691642.1">
        <property type="nucleotide sequence ID" value="XM_006691579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0U0"/>
    <dbReference type="SMR" id="G0S0U0"/>
    <dbReference type="STRING" id="759272.G0S0U0"/>
    <dbReference type="GeneID" id="18255160"/>
    <dbReference type="KEGG" id="cthr:CTHT_0011220"/>
    <dbReference type="eggNOG" id="ENOG502QT55">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016930_1_1_1"/>
    <dbReference type="OMA" id="WSGFYTR"/>
    <dbReference type="OrthoDB" id="5286354at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006080">
        <property type="term" value="P:substituted mannan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04086">
        <property type="entry name" value="CBM35_mannanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CBM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022790">
        <property type="entry name" value="GH26_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000805">
        <property type="entry name" value="Glyco_hydro_26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40079:SF4">
        <property type="entry name" value="GH26 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40079">
        <property type="entry name" value="MANNAN ENDO-1,4-BETA-MANNOSIDASE E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16990">
        <property type="entry name" value="CBM_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02156">
        <property type="entry name" value="Glyco_hydro_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00739">
        <property type="entry name" value="GLHYDRLASE26"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51764">
        <property type="entry name" value="GH26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408710" evidence="5">
        <location>
            <begin position="22"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="7">
        <location>
            <begin position="28"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="GH26" evidence="8">
        <location>
            <begin position="167"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="6">
        <location>
            <begin position="320"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS22650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="461" mass="51116" checksum="C25DA1D471C77B76" modified="2011-10-19" version="1">MTRALKSILLGIAALAVGTHAVPCQGPRTYQAEDAVLTGTHIDTAQPGYTGSGYVTGFDQSSDKITFKINSPSTRLYDLSIRVAAIYGEKRTTVVLNGASSSEVYFPASDSFITVSGGQVLLNEGANTLDIVSNWGWYLIDSITLTPSAPRAAHNINPNPVNPAANADAKALYNYLKSIYGKKILSGQQELSWANWISQQTGKTPALVSVDLMDYSPSRVERGTVGTAVEEAIQHHERGGIVSVLWHWNAPTGLYDTEENRWWSGFYTRATDFDVEQALSSTTNANYTLIIRDIDAIAVQLKRLQDAGVPVLFRPLHEAEGGWFWWGAKGPEPCKKLWNLLYDRLTNYHQLNNLLWVWNSILPEWYPGDDTVDILSADVYAQGNGLVELGQDKKMIAATEVGAAPLPDLLQAYQVHWLWFAVWSDGFINNAEWNSLETLQTIYNHDYVLTLDEIQGWRNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0V3</accession>
    <name>G0S0V3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0011360</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691655.1">
        <property type="nucleotide sequence ID" value="XM_006691592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0V3"/>
    <dbReference type="STRING" id="759272.G0S0V3"/>
    <dbReference type="GeneID" id="18255174"/>
    <dbReference type="KEGG" id="cthr:CTHT_0011360"/>
    <dbReference type="eggNOG" id="KOG3771">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025518_1_0_1"/>
    <dbReference type="OMA" id="MLAHYYT"/>
    <dbReference type="OrthoDB" id="10255128at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07599">
        <property type="entry name" value="BAR_Rvs167p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000100">
        <property type="entry name" value="SH3 domain-containing YSC84-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF2">
        <property type="entry name" value="SH3 DOMAIN SIGNALLING PROTEIN (AFU_ORTHOLOGUE AFUA_5G07670)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="5">
        <location>
            <begin position="7"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="415"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="362"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="376"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS22663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="474" mass="52364" checksum="E74235CCF87B733B" modified="2011-10-19" version="1">MLSMQKHFGRLWNKGPGDNAKASALLTDYEDADRVFAKIIDMTKQWKDAWTSLASSQLQLVAEFEGLYDPIVGASEGSRRQTTPTPQLQLERTFRLKKEYKELKTELLGEIGLIEEHVIRPAAEARKFIAPVRKTIGKRENKRLAYEKLQDKAIKIQRKPCRTTKDEAALAKLEVELSKAAEEFGVADEHLRKTLPPIIMATFNLIPPLLSNIVLIQTRLLGLYYTALHGYCQEIGLPSPPPPMNEVISTWCSTYGTIRQKVESLSIVARGNSAHKTLKLGDDILCPTGTGSNRTSSSSSSAKLHVRQCRVSSISSLEAPPFMTGNNPVAQPSSARQPNYTHPTDFTTTVALGGVDIVHPGQRTSRLHTSDDDSAVSPSTPSRNVGNNTKQSVLMAAKKKAPPPPPPPKRISGAKKEEWVIAQYAFAAQGPEDLSFQEGDKIKVLWRSKTDQDWWVGELNGVKGNFPANYCKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0X8</accession>
    <name>G0S0X8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0011610</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691680.1">
        <property type="nucleotide sequence ID" value="XM_006691617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0X8"/>
    <dbReference type="GeneID" id="18255199"/>
    <dbReference type="KEGG" id="cthr:CTHT_0011610"/>
    <dbReference type="eggNOG" id="ENOG502S6QC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029878_0_0_1"/>
    <dbReference type="OMA" id="CKKTGND"/>
    <dbReference type="OrthoDB" id="5401558at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="216"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="278"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="386"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS22688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="466" mass="52339" checksum="B6190AAB4305DFE6" modified="2011-10-19" version="1">MGDDYRRGAPEPPRDNPYPPLPESDDRRRLPPMSSDNVSLPPMSYPPPPPPAYPTEPRYPDRGYSDPRYPPDPRGWPPPPPPPEPAHQNGYSSQPDTRYPPPYPPQDPRQYDNRRPYDDRRPYDDRRPYDDRRPYEDQRAYDDRGQYHDGRAYPPPPPPPPPPDPYYDRQAAQGRVGGYGPDYYRYPPNYPYPMPPPPPPPPPPQQSAPRQRTSIACRYCRKRKIRCSGYTHTTNGKCTNCDKLKIDCIFQPVSSNSSTAFVPVQAVPGGVPPGTPLFGAYGQPLPPATTAPAPQARSYSQYPPSEYHPPVHSPTGAYPAYDDKDPGRRRPRPPEEEHGSRPPPPNYPVDDDPRRRSPVSMNSNGTPPTGYPPYQPQGPYDRDNKLPPPSHQSPARSLPPPSQSQAPPPPPIQPVQPSPQYHPPPPPQPSSSYSNPMSLDNLIGREPRSAVNDIDRSMLGRLDRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0Y7</accession>
    <name>G0S0Y7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0011700</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691689.1">
        <property type="nucleotide sequence ID" value="XM_006691626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0Y7"/>
    <dbReference type="STRING" id="759272.G0S0Y7"/>
    <dbReference type="GeneID" id="18255208"/>
    <dbReference type="KEGG" id="cthr:CTHT_0011700"/>
    <dbReference type="eggNOG" id="ENOG502SQKQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_662219_0_0_1"/>
    <dbReference type="OMA" id="TEPPFRD"/>
    <dbReference type="OrthoDB" id="4146887at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39609:SF1">
        <property type="entry name" value="RFEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39609">
        <property type="entry name" value="RFEG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="415" mass="47282" checksum="C0DBBD41AC04AD82" modified="2011-10-19" version="1">MEPGPRQNEYFIPRDGIAREVIQADICRWGYYEAPDGRVIQGYFITAYRNLTSAMIADLKEESRKHWEKQKAAAARASGSGSSARMHTNEPPRASVRSNSPGGSREQPRVNPEYNSWIGDQYDQVYPSSSMDVEYTTTSPVPTGTPSHGSQSYTSGPPPTYPQPAYQPPPVQSSPAAYQPQPGYAYPPNTPSTQYPPNPPPTQFPPNPPSTQYTPNPPPTQYPPNAPPTQYPPNPPPAQYSPPPQAPGDRYTAMAPPPMPNPYPQESAPYVHGSNYQTAPAYAAPAPVRIPPTMPVSTAPPSRTYSVPVSGTPVYGTEPDPYNYPASAPAFPADPLYGRDRDSEPRDRDWERDRERDRERDRERDWDRDRDRDWDRDWERDRERDRDRDRERDYHRTRWEAEREDRHVDRNRRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0S161</accession>
    <name>G0S161_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA (cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0012460</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="1"/>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691763.1">
        <property type="nucleotide sequence ID" value="XM_006691700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S161"/>
    <dbReference type="STRING" id="759272.G0S161"/>
    <dbReference type="GeneID" id="18255284"/>
    <dbReference type="KEGG" id="cthr:CTHT_0012460"/>
    <dbReference type="eggNOG" id="ENOG502RYYW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012943_3_0_1"/>
    <dbReference type="OMA" id="CCYWSPA"/>
    <dbReference type="OrthoDB" id="414133at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.120.10">
        <property type="entry name" value="DNA Methylase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050390">
        <property type="entry name" value="C5-Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629">
        <property type="entry name" value="CYTOSINE-SPECIFIC METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629:SF52">
        <property type="entry name" value="DNA (CYTOSINE-5)-METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS22771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="688" mass="77850" checksum="9BBF77E8C62AFAEA" modified="2011-10-19" version="1">MAGTEREPFIIDDEEEILINAHLRREIDEALRRGQEIARIAGVSHDFPISIDDDDGTIELEVAIEDILADGIGEVIDLTNENELPISGPDALIVRDEGIILDEWRLDNGKIIQTGMALEIAEPLGDHQIQFFRVQQIILPNNQNPIIRGWAFTRTKHLNGILPCKLNEVALIVESSSFDERPWEERALREIPTGAILRERELIITNTPFPEHRFSGWDYKAQGHEWVAANSRLVCRYRFEIQVNPANNKPCEWALIRLSEDEADPDFRIRDEALLNRWRGGKVPGGSSKHGAPQPLVVDIDADVDLQDAHRPVLAPEQRYTAGDVFAGAGGASRGIELAGVQLLFALDHWRPAANTLDANFGDRVNIHFMDVTEFINNENLQYDVDMLHLSPPCQFWSPAHTIAGKNDDDNIAVLYSCEHLIKKLRPRVFTVEQTFGILSPNFTAYFNAFILGFTSFDYSVRWKVVPLANYGIPQLRKRLIMIGAGPGDKLPSIPPPTHSKNRTGGLKPWNTPWSVVGNMAQYRHHPLHRPREVKLAQPRPAWDPTQLARTITCNGGQNYHWSGRRNFTLLEYALLQGFFPDHQFRGSYIKKQIGNAFPSRVVKVLYEHLVSFLLKQDGFDPDTRPGPILGNHWLYWPGNIDDNDNSDGDYETDSDTLDGKDDEIQIIWDSNWNNLGKGTKENPIVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2023-02-22" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>G0S167</accession>
    <name>G0S167_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0012520</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691769.1">
        <property type="nucleotide sequence ID" value="XM_006691706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S167"/>
    <dbReference type="GeneID" id="18255290"/>
    <dbReference type="KEGG" id="cthr:CTHT_0012520"/>
    <dbReference type="HOGENOM" id="CLU_1384010_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS22777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="197" mass="20723" checksum="D7E89408B4350723" modified="2011-10-19" version="1">MPMPNAQPHPVSALCTMAQQQRCIRDPSTLITITGVRCEQGIPTKKIRAPPWLPGPGQVRQQGKAAAAAAAAGCVLLVSAATCVPRPAVTVDLMRLDFVRFATRDGALALAGPTSAIDLIWTPLCGLFVSAAGLPANFCRLAAADSEVIGRRGPAVAQTQHHAQVLTAMDTAVVHSPALLGGFQVDFEPFKWRNRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0S193</accession>
    <name>G0S193_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0012780</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691795.1">
        <property type="nucleotide sequence ID" value="XM_006691732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S193"/>
    <dbReference type="STRING" id="759272.G0S193"/>
    <dbReference type="GeneID" id="18255316"/>
    <dbReference type="KEGG" id="cthr:CTHT_0012780"/>
    <dbReference type="eggNOG" id="ENOG502R6EY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082457_0_0_1"/>
    <dbReference type="OMA" id="GAPECAQ"/>
    <dbReference type="OrthoDB" id="5244855at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013130461" description="Extracellular membrane protein CFEM domain-containing protein" evidence="3">
        <location>
            <begin position="16"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS22803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="29741" checksum="36D362682C37AE0D" modified="2011-10-19" version="1">MRTIAILATASIASAVQVWWGGAPECADDCFSSFWSSASTWPAPFEYCSATQGPDVLNCLKSKCSATPTAITSYSSLSSALCANWASCSAAGSTGVYTVSLPGFTGAWGPGHSGPYPGGRWGAWGYPHPMPTSAPDASNPAYDWADGRWHDWTRTWSGGVYTVTGCEWDGNPWAGGPGGWGPGGAGGSPWGPWGKGWKWTTTTEIITRVVTKTDDGTTSLVTSVGPATVALAVSGDITSTSVLNAQETDSSGSSGGSGSSSSDSGAAAGRGEPAAGVMLMGTLLAGVVVVAGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1A8</accession>
    <name>G0S1A8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA-directed RNA polymerase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0012940</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691810.1">
        <property type="nucleotide sequence ID" value="XM_006691747.1"/>
    </dbReference>
    <dbReference type="GeneID" id="18255332"/>
    <dbReference type="KEGG" id="cthr:CTHT_0012940"/>
    <dbReference type="eggNOG" id="KOG0988">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001366_0_2_1"/>
    <dbReference type="OMA" id="AFVMSKP"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF55">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="154"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1400"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1495"/>
            <end position="1543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS22818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1626" mass="184776" checksum="DF2739C09D572ACF" modified="2011-10-19" version="1">MPDATCSDADGQEINGSDFEDPSSQGTAEVLTPVQPPEPWQQESRGGYQSRGIRGFRRGGRGRWRGNHGMRHSPAPRDTRRPFNHNNDDAPRRTRARSQHPPRLSPAPRDPRQLSGAARRSSLAPSFPTQHLPAVVPQPSLLTLPENWHSQKSATILLYGVPEKASAWEVRQFFENYGRVVHVELEDPDSARKARRFAKVKFEPPPTDTSFIRDGECRIVINNYASWARIEIPRQSSNARMITTPVGGTCAPSLTVRLVKLTFGLLIQPTTFMRKKEFANVGQDAHHSLQLTADFRRKRVMINFSVNVDHFHAGQYRLEMRFEIIKRIHRFSQDGRVRLVIVCADAPLVRQRRDDQNGRLLADRLVWGENELWYRVTDIETSSSLDHMRTPLSLDEGEYKFVDLGRWTTYMLDIDDCEAWLEIETLLRDWNIKTDLDTTFDQVSGKRSMLWDVLADMTLEAPAASSNSLCFSDLVLLGFPTNTSLPFDIRYQLEVCLSRGVLCEYNITQEFLDKLLELSKPDGMEVSRARLILEYAADQGKRIWDPMSLFSDQAALSYCPTTLHIPSHCALVRKVTITPTRIYFSTPTVETTNRVVRHYGRFRDYFIRVQFTDEVMEGRIRSSYTDREDNVYARVFRVLRHGIRMGKWHWKFLAYGNSQIRECGSFFFCEPEEAHGTITCDSIREWMGRFSHIKSIAKLAARLGQCFSTTRPLPGITAPTIIKTQDVERNGYCFTDGVGKISPLLAFFIAEDWKVYPTPSAFQFRMGGCKGVLVTWPDAKGTEVHIRPSQEKFSAEFNGLEIIRCSHFSCATLNRQTITILSCLGVPSYVFLDMMEEQLANYDAAMEDPDKAIDLLTTYVDENMTTLTMSEMVLDGFMETREPFVRSLLQLWRAWSIKALKEKARLVVKKGAFVLGCVDETGTLRGHSRATEGTKNQPKEVRRDQLPQIFLQVPDHENGGTYKVITGLCLVGRNPSLHPGDIRMVEAVDVPQLRHLRDVVVFPLQGDRDVPSMCSGGDLDGDDYFVIWDEKLFPKEWSYPPMNYEAPKAPEEKEVMVANNLAEFFVLFMKNDRLPLIAHAHLATADKHPEGAKTEKCLELAQLHSTAVDYVKTGVAAKWEKRLDPRTYPHFMEKSRARTYYSKSVLGQLYDMVERQVFDIQENYKLPFDERIIKRYELNDDLLRQARKLKSQYDIAMRRIMGQLEIRTEFEVWTAFVMSKPRVGTDYKVQEKVGREAACLKKQFRDLCLKAAGASDRGDFEKLGPFVAAMYRVTCEEIRIALYEARQPHRRPDGTMGLRKITARSMPLISFPWLFPAELGRIATGIERKGTEKVARLRISVLNKPTYAKGICIPVDLKTEADFAAMDYTRTSDGRFIHRGEILNLFHHDDEKANDEYYCNEGVDFSDSGDDSEEASQSGDEGRDGSELKTNIGRISPESAEAAGNVAEGRPPDFSQQQSSAPSATVLDLLVEDLKDATSFLPPPLVPLPVAAFPEQQQQEDEEQQQQQPEELESPQRQKHQVLRAGPEELDPPASKEHPDITEEVDLSTLAADVVAEDTSGLSNSSCSILMAEPNGSYVDENKLDVEYARDNNELSADSDGSEVEYENIVLDIEEESVLERLARFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1C7</accession>
    <name>G0S1C7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">COQ4</name>
        <name evidence="9" type="ORF">CTHT_0013130</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Lyase that catalyzes the C1-decarboxylation of 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid into 2-methoxy-6-(all-trans-polyprenyl)phenol during ubiquinone biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + H(+) = a 2-methoxy-6-(all-trans-polyprenyl)phenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:81179"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="4.1.1.130"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion inner membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
            <orientation evidence="7">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the COQ4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691829.1">
        <property type="nucleotide sequence ID" value="XM_006691766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1C7"/>
    <dbReference type="STRING" id="759272.G0S1C7"/>
    <dbReference type="GeneID" id="18255351"/>
    <dbReference type="KEGG" id="cthr:CTHT_0013130"/>
    <dbReference type="eggNOG" id="KOG3244">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061241_0_0_1"/>
    <dbReference type="OMA" id="YYERHFH"/>
    <dbReference type="OrthoDB" id="4249at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120539">
        <property type="term" value="F:4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03111">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007715">
        <property type="entry name" value="Coq4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027540">
        <property type="entry name" value="Coq4_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05019">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="284"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="284"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="311"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00081568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS22837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="323" mass="37176" checksum="0DDE83282C727CCF" modified="2011-10-19" version="1">MEVVFRRPAAAISRPKGLKPAASVLVTVSTSSPLSQSQLQLQLQPQQRRPFTFSSLTRPPPNYPGHVPLSFIEKAALAIGSGLMSLRDPRRGDLIAAFAEATATPYFIYRLRDAMLSHPTGRRILRDRPRITSTSLNLPHLRSLPPNTVGRTYVEWLDREHVSPDTRAPVRYIDDEECAYVMQRYRECHDFYHALVGLPTVREGEVALKAFEFCNTLLPMTGLSVFAAGTLKPRERKRFWEVYLPWAVRNGLRAKEIINVYWEEELERDVNDLRAELGIEMPPDMRELRRREREERRRRKAEEEEARRMAAMEAAKAAQGQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1H7</accession>
    <name>G0S1H7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase C14 caspase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0013640</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691879.1">
        <property type="nucleotide sequence ID" value="XM_006691816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1H7"/>
    <dbReference type="GeneID" id="18255402"/>
    <dbReference type="KEGG" id="cthr:CTHT_0013640"/>
    <dbReference type="eggNOG" id="KOG1546">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016732_1_0_1"/>
    <dbReference type="OMA" id="IHRHLCA"/>
    <dbReference type="OrthoDB" id="4584361at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="610" mass="68085" checksum="6FC151D2686BF848" modified="2011-10-19" version="1">MNAQPDTAAYHALLIGINDYPDKPLKGCVSDVYYIKSHLEDTLGDAIQIHLLIAGIPAGQDLDLSAQNSALWPSYHNVISALRNITTQSKEGDCVYIHYSGHGTQDPEDGDLALVLLNENLGQPQIELLWTDVLANMVQAMVDKGLRVTLALDCCFSGGIFRGDGPEEGEILRFYPYDKVTRKRPASSHSRTCNSASTRPSAYRDLSALLNWQVDPNRHAILAACGANETAKEPKINGQNRGLFSYFLLDAMKKYGLSASHADIFSYLSGNVKASGVRRQNPWRAGNRNQAFFGRQLHRRTTESLITVLRDRDGTLELQAGHAHGICAGDEFSILPASVALQSSAQDSAIYKVLFARPLTFPVWIPRNLPAFEEWITALQQRSLQLSDFPQTPPAFEVALIQDGGYRILNGSSEELLILPSRAKPSISDVVNILEHLARYQLARTLVNQFPNPIFTQSYEVYMQLFGKRYEPGSELKVSNFSKISLVVRNLGNQPIYMVVLNFRHGWQVNNLFNATYNVILPRSEGRSSERTISFRAQVPDEVMEKGQNECKDVLRVMLTSRPTSFELLELDRLGEVKERLSKESSVRAGGDDEEEEIWSVEEFCICVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1L6</accession>
    <name>G0S1L6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">O-methyltransferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0014040</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691918.1">
        <property type="nucleotide sequence ID" value="XM_006691855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1L6"/>
    <dbReference type="GeneID" id="18255442"/>
    <dbReference type="KEGG" id="cthr:CTHT_0014040"/>
    <dbReference type="eggNOG" id="KOG3178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005533_1_4_1"/>
    <dbReference type="OMA" id="SIIEAVW"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF16">
        <property type="entry name" value="O-METHYLTRANSFERASE ELCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="337"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="29"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS22926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="523" mass="58646" checksum="A425158FDACE591A" modified="2011-10-19" version="1">MPPDPDSPDFWGRIVLSVKMTKKFRLSAIFNGTSSSSPAGDEETKKQNRRSFSLATSLKNLREGKTKSESSSNSSDSTAEGQSTSRMAALAQQIARDTEKLEAYMRENDLPIPTSDVDSPSQYPKLPEDIQRLKQDIIAATRELNRLAHGPQEYLRWGVWAFLDVLALTIINHFGIAKLWPPNETITLAELQTKTTLDPINLARVLRAAMTNGIFREPEPGVIAHTAASRALAEDDNLQAWIGFNCEDIFPASAHVLQALKAFPEATSLTRAGFQFAFDTVDREPMFATFGKDPARARRMGKAMVSLTGGEGYEPSYFVDVEKGGYDFSDLDARGGVFVDVGGSHGFICVELAQRYKNMKFVVQDLPKTIDTAPKPIHSDPQVASRIELMAHDFFTEQTVKGADVYYFRWIMHNYSTPYAVRIIKNLVPALKPGARVLINDHCLREPGAENAWDERVMRHMDLVMLTLLNAQERTEDEFRELFRAADEGFVFKGVRRAPGCRMSVIEAVWKPDEVEKEEEKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0S225</accession>
    <name>G0S225_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0015740</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS23085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692077.1">
        <property type="nucleotide sequence ID" value="XM_006692014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S225"/>
    <dbReference type="SMR" id="G0S225"/>
    <dbReference type="STRING" id="759272.G0S225"/>
    <dbReference type="GeneID" id="18255612"/>
    <dbReference type="KEGG" id="cthr:CTHT_0015740"/>
    <dbReference type="eggNOG" id="ENOG502RZYG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032571_1_1_1"/>
    <dbReference type="OMA" id="YGHMQLA"/>
    <dbReference type="OrthoDB" id="2342176at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409225" description="Extracellular protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="43332" checksum="34225896C86F95D5" modified="2011-10-19" version="1">MLSNIFTTGALVALLAGSQLASAHMEIRYPPPFRSKFNKFATDIDYTNTAPLAADGSNYPCKGYHVDMGTAAGEVVDTWAPGARVNFTVEGSAPHGGGSCQVSLSYDGGKTFTVIHSIIGDCPNSKFYEYNIPDDAPEGVAIWAWTWNNQIGNREQYMNCAAVRISRSAAKRDVPVVAKSVEEQPKKEAKRASVPFSSRPPVFIANIGNGCVVPEGIDVEYPNPGPDVVVNPGHLGKPQGNCGAPAAAPAPIPDPTPAPAPTPTPTGLPGGVFVTVSPSSSSQVVEQPVTTSVVENNTPTPAPTTLITTTAVPTPTPAPTEIATPAPTPGSGSGSGSGSGNTNGGSGSAYAVGAACTNEGAWNCVNGGTAFQRCASGRWSAVISMAAGTKCVAGESSALAFSVKRDGEKVKPRFRGGAKMILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G0S254</accession>
    <name>G0S254_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Argininosuccinate synthase</fullName>
            <ecNumber evidence="6">6.1.1.20</ecNumber>
            <ecNumber evidence="5">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Citrulline--aspartate ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Phenylalanine--tRNA ligase, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Phenylalanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">CTHT_0016030</name>
    </gene>
    <organism evidence="27">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">Belongs to the argininosuccinate synthase family. Type 1 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="6"/>
    <dbReference type="EC" id="6.3.4.5" evidence="5"/>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS23114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692106.1">
        <property type="nucleotide sequence ID" value="XM_006692043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S254"/>
    <dbReference type="STRING" id="759272.G0S254"/>
    <dbReference type="GeneID" id="18255641"/>
    <dbReference type="KEGG" id="cthr:CTHT_0016030"/>
    <dbReference type="eggNOG" id="KOG1706">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2783">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_303468_0_0_1"/>
    <dbReference type="OrthoDB" id="1688907at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000053">
        <property type="term" value="P:argininosuccinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="ASS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000019">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1260.10:FF:000003">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.380:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000053">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="entry name" value="Argininosuccinate synthetase, chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="entry name" value="Ferrodoxin-fold anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00005">
        <property type="entry name" value="Arg_succ_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048268">
        <property type="entry name" value="Arginosuc_syn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048267">
        <property type="entry name" value="Arginosuc_syn_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00469">
        <property type="entry name" value="pheS_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001770">
        <property type="entry name" value="PRK00509.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587:SF2">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20979">
        <property type="entry name" value="Arginosuc_syn_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="Anticodon-binding domain of PheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="Argininosuccinate synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="16 26" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="24">
        <location>
            <begin position="671"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="25">
        <location>
            <begin position="889"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="720"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="732"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00057761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00060987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00073229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="EGS23114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="981" mass="111268" checksum="AB522CD8584F54A3" modified="2011-10-19" version="1">MSKGRVCLAYSGALPVAWIWISIAFDLPDLNKTDTQIPGLDTSTILKWLILEGYTVVCFLANVGQQEDWAEVEKKALALGAERMVIEDLQREFVEEIVFRAIQCNAIYEDRYLLGTSLARPIIARAQVRVAQQYNCEYVSHGCTGKGNDQVRFELAFKACNPKLKVIAPWRMPEFIQRFQGRADLLKFAAENNIPVSATPKAPWSMDDNLVHCSYEAGVLEDPDYTPPKELWTRTVDPQDAPDKPYNFTIHFEKGIPVKLVTPEGEVTDSVELFKTLNKIGHDNGVGRIDIVENRFIGLKSRGCYDTPGLTIARLAHIDLEGLVMDSRVRKLRDQFVTIEWSHCLYNGMYFSPEREFLENSIIFSQQNVTGEVRMSVYKGNAYVLGRKSNTSILYSQEDASMDSLETFQPMDTTGFIAIQGIRLEKYGLQKIKDGQPLSNDIGVEKFKIAKAPAELREPLGLSFKQLTNHVEPSAGPCHLEPHSETSMVGPRVVMAALRPGAGACSNISWPLRQGSSRLRIITPVLRLRVFSYSRYYSPAESRVSPTPNAQKTVTINGRSYPTDSWYNVSSTVLSLTSRKLHLQKDHPVSITRKIIESVFPGPTYKYYNEFDPVVSTHENFDSLGFPPDHPGRARTDTYYINQSTLLRTHTSAHEAQLFRENDTGGYLISADVYRRDEVDRSHYPVFHQMEGARVWDRRLVPNGDLVAAVYEDLERLPKHNMTVEDPNPPFHPERNPLQEGHHTPEEAAAIAAHLKRSLELMVNEIFTRAKAANVAAAGGSPQQDEPLRVRWVEAYFPFTSPSWELEVHYNGDWLEILGCGVSQQHVLNNAGVPHKSGWAFGIGLERVAMLLFKIPDIRLFWSQDERFLSQFRGVEDDLSKIRPFVPFSKHPACYKDVSFWLPKDEFHENDLMEIVRDAVGDVVEDVKKVDEFVHPKTGRKSMCYRINYRSLERTLTNTETNEMHDRVVKGLVAKLGVEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0S312</accession>
    <name>G0S312_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0019260</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692414.1">
        <property type="nucleotide sequence ID" value="XM_006692351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S312"/>
    <dbReference type="GeneID" id="18255964"/>
    <dbReference type="KEGG" id="cthr:CTHT_0019260"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_1_1"/>
    <dbReference type="OMA" id="KWTVIIG"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000180">
        <property type="entry name" value="MFS monosaccharide transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF6">
        <property type="entry name" value="MSTA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="492"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="535"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="574"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="609"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="161"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="646"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS22395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="680" mass="73816" checksum="0EBCD9007D3DFC9F" modified="2011-10-19" version="1">MTLPQETCSTRHRQTPRQSRTEQAAGEEHYQRVCRASSGRQQSGQLAAGLPFTTCFSQQGFNSPAAGDPWAGPPGMPKMAGNTTCSRCFLPGEGDGDSELTAWLSGWPRLQELALLCCGIMGEKVEREEDVAVATHHAAGLATTDDVERIEAPVTWKAYLICAFASFGGIFFGYDSGYINGVLAADIFIKAVEGPTATSVSESHQSLIVSILSCGTFFGAVIAGDLADWIGRKWTVILGCLIYIIGVVIQTITGLGDALAAIVAGRLIAGIGVGFESAIVILYMSEICPRKVRGALVAGYQFCITIGLMLASCVIYATEDRTDTGSYRIPIAIQFVWALILAFGLMCLPDSPRYFVKKGNLNAAAASLSRLRGQPENSEYIQVELAEIVANEEYERQLIPATTWLGSWANCFKGSLWKSNSNLRKTILGTSLQMMQQWTGVNFIFYYSTPFLKSTGAIKDSFLMSMVFTIINVFSTPVSFYTVERFGRRTILFWGALGMLICQFLVAIIGVTVGFNHTHPDPADPEATLANNVSAVNAQIAFIAIFIFFFASTWGPGAWIVIGEIFPLPIRSRGVGLSTASNWLWNTIIAVITPYMVGENRGNMKSSVFFVWGGLCTVAWIYTYFLVPETKGLTLEQVDKMMEETTPRTSAKWKPTTTFSAGGVKVTKGAGSGSDSKEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0S346</accession>
    <name>G0S346_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0019620</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692448.1">
        <property type="nucleotide sequence ID" value="XM_006692385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S346"/>
    <dbReference type="GeneID" id="18256000"/>
    <dbReference type="KEGG" id="cthr:CTHT_0019620"/>
    <dbReference type="eggNOG" id="ENOG502RNEZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019054_0_0_1"/>
    <dbReference type="OMA" id="YVYAQMI"/>
    <dbReference type="OrthoDB" id="5337493at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11748">
        <property type="entry name" value="GH94N_NdvB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.40">
        <property type="entry name" value="Glycoside hydrolase, family 65, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037018">
        <property type="entry name" value="GH65_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033432">
        <property type="entry name" value="GH94_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052047">
        <property type="entry name" value="GH94_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037814">
        <property type="entry name" value="GH94N_CBAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010383">
        <property type="entry name" value="Glyco_hydrolase_94_b-supersand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37469:SF2">
        <property type="entry name" value="CELLOBIONIC ACID PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37469">
        <property type="entry name" value="CELLOBIONIC ACID PHOSPHORYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06165">
        <property type="entry name" value="GH94_b-supersand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17167">
        <property type="entry name" value="Glyco_hydro_94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl hydrolase 94 supersandwich" evidence="3">
        <location>
            <begin position="74"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase 94 catalytic" evidence="4">
        <location>
            <begin position="318"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS22429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="569" mass="64823" checksum="C515EBC7AF3DC190" modified="2011-10-19" version="1">MRREAIIRPSNNGNRYELTSPTVMPKAAGFLWNQKMMIQITCRGYATAQFMQPEPSKYAHAPNIEAKTFMQPEQNYYTHHPGRFVYIKDLETGKLFSAPYEPVRAPADRFVFSVGKTDVAWSVENLGIRVEMAMGLPTHDVVELWTIRVTNISGRPRTISVTPYFPIGYMSWMNQSAEWNPELVGIVASCVTPYQKAEDYFKNKYLKDKTYFICETPPDSWEANQEAFEGEGGLHCPSALQLPQLSGSDARYETPTAAVQYLLSLGPGEEREYRFIFGPAYDEAEVREMKNRYLSKQAFLRTAAEYAAYMERGRGCLYIETPDKDLDNFVNNWLPRQVYYHGDVNRLTTDPQTRNYLQDNMGMNYIKPEVSRKAFLTALSQQRPDGSMPDGIILVEGAQLKYINQVPHTDHCVWLPVTLELYLSETGDYSLLEEYVQTKKDNFTVFERLCRAMDWLLKARDERGLSYIAQGDWCDPMNMVGYRGKGVSGWLTLATAHALNLWADVCEHEGKKNLAKRYRDGADECNSAANKYLWDGDWFARGITDDNVVFGVKKDPKAASGSIPNPGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2023-02-22" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>G0S355</accession>
    <name>G0S355_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0019710</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692457.1">
        <property type="nucleotide sequence ID" value="XM_006692394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S355"/>
    <dbReference type="GeneID" id="18256009"/>
    <dbReference type="KEGG" id="cthr:CTHT_0019710"/>
    <dbReference type="HOGENOM" id="CLU_1805963_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS22438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="143" mass="16071" checksum="4CB18E347B26C220" modified="2011-10-19" version="1">MFSSFPIPHPLPPASPPPWLPLILINIKNVANGPQTRTFEAELLALERFAVLCMAFADLGGHANVWVNPILLNIQNVNNEHLKHIFHWATQYKDLPKEQTMVELMATRRKSGHNKVEAKASEALPAERAAARERIKIHTWDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3E5</accession>
    <name>G0S3E5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucoamylase</fullName>
            <ecNumber evidence="9">3.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,4-alpha-D-glucan glucohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glucan 1,4-alpha-glucosidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0020730</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Hydrolysis of terminal (1-&gt;4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 15 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.3" evidence="9"/>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692547.1">
        <property type="nucleotide sequence ID" value="XM_006692484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3E5"/>
    <dbReference type="SMR" id="G0S3E5"/>
    <dbReference type="STRING" id="759272.G0S3E5"/>
    <dbReference type="GeneID" id="18256111"/>
    <dbReference type="KEGG" id="cthr:CTHT_0020730"/>
    <dbReference type="eggNOG" id="ENOG502QPM2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012173_1_0_1"/>
    <dbReference type="OMA" id="QHRAMVE"/>
    <dbReference type="OrthoDB" id="6123450at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004339">
        <property type="term" value="F:glucan 1,4-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000018">
        <property type="entry name" value="Glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000165">
        <property type="entry name" value="Glucoamylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008291">
        <property type="entry name" value="Glucoamylase_SBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616:SF12">
        <property type="entry name" value="GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001031">
        <property type="entry name" value="Glu-a-glcsd_SBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00736">
        <property type="entry name" value="GLHYDRLASE15"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="CBM20" evidence="12">
        <location>
            <begin position="538"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001031-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001031-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS22528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="663" mass="72550" checksum="85B7C57CCBB64B71" modified="2011-10-19" version="1">MRKLTANSVLQLKIASLMQVAPKLTAPDYHDYIQLEKLIKDKTHQSSQGLAGAIPQTLSLEKWIKTERAIALEGVLDNIGANGTKVAGAGRGLVIASPSKSNPDYFYTWTRDSALTFRTIIDDFLFGNKALQPHIENYIYSQAILQTVSNPSGSLLPNGAGLGEPKFNADGSRYNGNWGRPQRDGPPLRAISLIQYSNYLISQEQKERVKREIWPIISNDLNYVGQYWNATTFDLWEEVSGASFFTTQSQYRALIEGSTLAKSLNLSCPACSQAPQILCLLNSYWNGAYYTANFITSTAGQPTGRVGIDANTILGPIMAFDPNASCNSPTLQPCHPKSLANFKAVVDTFRTLYPINEGIPVGKGIALGRYPEDTYFGGNPWYLIVHGAAEFLYDVALSWSRQGQITITSTSLPFFKDLYPSAKIGTYSKSHPTYHALAKAVHAYADSFIEVSKKYTPSNGMQAEQFLRISPGTPTSAANLTWSFASFISMTHRRDGHLPASWVPTGRNAPVLPQICTPSDGSFIGTFAPATEAGAPNIKIPCLTTVRFMVDAPTYYGENVFITGSTPTLGNWDVSKAYPLLSSNYTAERPLWWADVLLEFEEGFKGGEVRYKYARQQDCGQDWIVEQDERVVTVPGCKVGGSGVVDVVVEEVFNGDGGTPGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3F0</accession>
    <name>G0S3F0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0020780</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692552.1">
        <property type="nucleotide sequence ID" value="XM_006692489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3F0"/>
    <dbReference type="STRING" id="759272.G0S3F0"/>
    <dbReference type="GeneID" id="18256116"/>
    <dbReference type="KEGG" id="cthr:CTHT_0020780"/>
    <dbReference type="eggNOG" id="KOG3155">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094365_1_0_1"/>
    <dbReference type="OMA" id="TPSKWWL"/>
    <dbReference type="OrthoDB" id="200404at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1760.10:FF:000002">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1760.10">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007204">
        <property type="entry name" value="ARPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036753">
        <property type="entry name" value="ARPC3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12391">
        <property type="entry name" value="ARP2/3 COMPLEX 21 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04062">
        <property type="entry name" value="P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016315">
        <property type="entry name" value="ARP2/3_P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69060">
        <property type="entry name" value="Arp2/3 complex 21 kDa subunit ARPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS22533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="192" mass="22077" checksum="7042E3C6EA9596C4" modified="2011-10-19" version="1">MPAFNSMFNNDPNPPRLIGNFPLLPLRTKLRGPVYPLPFPDPPLPANESPDPDSESYDILDETLALFRANTFFRNFEIQGPADRLLVYGIWFISDCLSKIRPTASLREATKDVMNLALDLNFAIPGDPGWPLNQMYEPPRDRQDAETLRQYMSQVRQELATRLLARVYADDETKPSKWWLSFTKRKFMGKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3L6</accession>
    <name>G0S3L6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0021700</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692639.1">
        <property type="nucleotide sequence ID" value="XM_006692576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3L6"/>
    <dbReference type="GeneID" id="18256208"/>
    <dbReference type="KEGG" id="cthr:CTHT_0021700"/>
    <dbReference type="HOGENOM" id="CLU_1864900_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS20343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="137" mass="14839" checksum="5ED599FE51B99364" modified="2011-10-19" version="1">MSAETRNVKTGVTIKEVNLPSKGPFQRGVPIRGFTVKAIIDRSSEYRSMGGSMVAMLVADGGRSLKDGQSALSGPRNIQPVTNESGEIVGEDITFHTMELRIDDKGEYQLRAKIEFVDGNESEVIATAKNVGRLVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3L9</accession>
    <name>G0S3L9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone-lysine N-methyltransferase SET9</fullName>
            <ecNumber evidence="12">2.1.1.372</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Histone-lysine N-methyltransferase set9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">SET domain protein 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CTHT_0021730</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Histone methyltransferase that trimethylates 'Lys-20' of histone H4 to form H4K20me3.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:64456"/>
            <dbReference type="Rhea" id="RHEA-COMP:15554"/>
            <dbReference type="Rhea" id="RHEA-COMP:15998"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.372"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.372" evidence="12"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692642.1">
        <property type="nucleotide sequence ID" value="XM_006692579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3L9"/>
    <dbReference type="STRING" id="759272.G0S3L9"/>
    <dbReference type="GeneID" id="18256211"/>
    <dbReference type="KEGG" id="cthr:CTHT_0021730"/>
    <dbReference type="eggNOG" id="KOG2589">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013724_0_0_1"/>
    <dbReference type="OMA" id="FANHDCG"/>
    <dbReference type="OrthoDB" id="6627536at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140943">
        <property type="term" value="F:histone H4K20 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10524">
        <property type="entry name" value="SET_Suv4-20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1700">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041938">
        <property type="entry name" value="Hist-Lys_N-MTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025783">
        <property type="entry name" value="Set9_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039977">
        <property type="entry name" value="Suv4-20/Set9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977">
        <property type="entry name" value="SUPPRESSOR OF VARIEGATION 4-20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51567">
        <property type="entry name" value="SAM_MT43_SUVAR420_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 17" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="16">
        <location>
            <begin position="117"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="275"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="568"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="460"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="471"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="568"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGS20346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="609" mass="68365" checksum="9092843143801189" modified="2011-10-19" version="1">MAPRASTSSKKKHQLTLAQLAAYDDILTDALVDHTYYWTTVPKNRTSYHPSRGIREEEITKILRDHVIVDPNLDLAEQKLLETPGLKKVYSALKTPEEKKDFRDHLRRYMSIYLPDCPFEVNATNRYTIVTFEACVTARRFIKKNETIKYLSGTQVTVTPEEEREMALRKKDFSLIVSSRSKSTSLFMGPARFANHDCNANARLVTRGPAGIEIVACRDIEVGEEITVTYGDNYFGENNCECLCATCEKNLANGWKPLDGTVIVQRSIEEDAQGYSLRRRRRDDSATGLASRTSSVTPDIRPRIKRTRSQKNLAGRAPMTASVEPGSRLLSPSSARKRVRDLAPLSSPPNTPAKKLKTRHSGVEPISMDVDSSRDSSETDNCASPLSLANDNGDTTGATSPDPAILTPEFSPHKHKAQGGSSGSYNSDIESQPLPEPVSPMWESSTKEESSETTSTGSKEWMEQKVRDSEATATKQKNQEPQQSSPPKRCQKKKSLPPQPPSPPRRPRIPGDYTLTPLLLSEPETAWIYCTNCNEAFVQRDAYFTKANCPRCERHSKLYGYLGPEEEARARGRKGWRERLAEKKARESMSSTRDDEDMEERGRKRVRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3T6</accession>
    <name>G0S3T6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribokinase</fullName>
            <shortName evidence="9">RK</shortName>
            <ecNumber evidence="9">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0030580</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-ribose + ATP = D-ribose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="9"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693508.1">
        <property type="nucleotide sequence ID" value="XM_006693445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3T6"/>
    <dbReference type="STRING" id="759272.G0S3T6"/>
    <dbReference type="GeneID" id="18257096"/>
    <dbReference type="KEGG" id="cthr:CTHT_0030580"/>
    <dbReference type="eggNOG" id="KOG2855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_2_0_1"/>
    <dbReference type="OMA" id="DIVLIQQ"/>
    <dbReference type="OrthoDB" id="415590at2759"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="Ribokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584:SF166">
        <property type="entry name" value="RIBOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 9" id="KW-0630">Potassium</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="10">
        <location>
            <begin position="5"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="13"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="41"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="246"/>
            <end position="251"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="278"/>
            <end position="279"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS21212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="330" mass="34679" checksum="F12E5B7B76C3A7EA" modified="2011-10-19" version="1">MTLPHITVLGSLNMDLVAYVPHHPLPGETLTADAFATSPGGKGANQAVACAKLSRDRPIEEHKEGGPWKGETAHVSMVGVVGKDGYGSQLRGNLARYGVDVSGVVESKEATTGVALIIVDKPTGENRIVLSPGANHVLTEGDFKNGLGLLGEGKPDLLIMQLEIQFGAVLAALKAAKEAGVDVLLNPAPARKLPDEAYQGLAHLVVNETEASILGEVEVSVLDTEEGLERVARGFVEKGARNVIITLGGRGVYYMSRDGRKGLTPAEKAKVVDTTAAGDTFVGMYALDAVGKRDGEFDIEAAVKKANKAAAKTVERAGAQDSIPWRDELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3Y0</accession>
    <name>G0S3Y0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0039270</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS22042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694338.1">
        <property type="nucleotide sequence ID" value="XM_006694275.1"/>
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    <dbReference type="AlphaFoldDB" id="G0S3Y0"/>
    <dbReference type="STRING" id="759272.G0S3Y0"/>
    <dbReference type="GeneID" id="18257965"/>
    <dbReference type="KEGG" id="cthr:CTHT_0039270"/>
    <dbReference type="eggNOG" id="KOG0717">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006836_0_0_1"/>
    <dbReference type="OMA" id="YGPPKAN"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="9"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="870"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="178"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="552"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="577"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="629"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="650"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="709"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="749"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="797"/>
            <end position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1015" mass="110030" checksum="0637E5CE3A674CA0" modified="2011-10-19" version="1">MAKLDLTRDYYADLELPVGADINEVKKQYRKLALKWHPDRNPGKEDEAKEKFLIISTAHEILTDPAQKAKVDAALRQRKARYPTASGVRGNPWANMAHEVNAKYGPPPQRPPMPTRPAASASASASNRYWDWGQKVKTKMDQARASSDAWERSRPQPKPASQPGPSAASAYRQSTARPTNPPPPPRSAAQARRQEASFGTRKQGFAPQAPGGDEPPVKNHHYTTTPKESMPIPPDEDETEPKKRDNTEPLSSQFRETFLDPRQRTPYAANVGERTNPFEPLNSVNRAKSMRDPGSRQFRGGGDDPARSPTAGRQRSHSVGNDGPFTRGAGQETSGNGARPSTFQNNTTNAPPTGSAFATGPSFQFGTRAAANNANGETRSSETSNMYGPPRSFSPYRRAYEQSAPDRPYPEVYRMHHSTEHRDRMRGGPWAEEIYSTPSGASRAFWQPSSAGAVPHGYVPRDSAQWQQPACSPTPSGMRRPTLNAGPNSFERMLHAQLQQVLAKAYAKRQPEQPSPSNPEPSGYVLGPKKTPAYRVSKSTAANSSHPGSFSSVPLGAATPETARFTRNSTDNINTQFVAEEKPGFHFSAGTPSPTNSPSDDHFTRAKQRARGHQSPLRNTFTASDESIAGNAAANAGATNNQQQAGSPKKIGDFKPDEWKELFTPHIFEPPQPSKLSSSPTRPIRPIKKRTTARAGASGMAARVESDSESSSSSSSNSSNSDETPRPTTAKTSGGIDGTRSPNAMDIDSPAAASPSPSPAAAPGAAPPQQANNARNVNVEPTKPEWRPGNVNNIPLGTNGTAPTNDTTTAEPKLGANIKIPHANHAGSEDTDPLLRPLFPDFRNTEPFAPPKPAGLDSFADLGSNLPFPSRPAAKVPISKDSPKKTVQLKMPSPPAAPKPPAQILEILASGAKPANGASTLNSAWISYTAEMKRYFEEWSAWNRRVTDHFAVRQRKHEDKGWAWVAAIGVDAPGVAEYLRAMEEDRVVREGWESAWRVHERVVGEWVALRAKVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4A7</accession>
    <name>G0S4A7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0039500</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS22065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694361.1">
        <property type="nucleotide sequence ID" value="XM_006694298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4A7"/>
    <dbReference type="GeneID" id="18257988"/>
    <dbReference type="KEGG" id="cthr:CTHT_0039500"/>
    <dbReference type="HOGENOM" id="CLU_1299561_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408816" evidence="2">
        <location>
            <begin position="22"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="212" mass="21225" checksum="3985BF36769E4DA3" modified="2011-10-19" version="1">MFGHHILTTALAVSNLGLATARVANIMMPACNAEQALAEAKALAARDASDVTTVTVTVTASATTTITLTGAGAVVTITTVTPCATVTQTVPVPIPESSTTEILPPPPATEPSTTEFVTQTSTLTQTFTSTFTSGTETITTTFTSIPGVTETSTNSLAPPISPDTTITSLLVSSTTSTASNPPTSTPASAGAGSNKVGNLVGIGAMMFGMMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4E8</accession>
    <name>G0S4E8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylulose kinase</fullName>
            <ecNumber evidence="7">2.7.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0022560</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Highly specific D-xylulose kinase which participates in the catabolism of xylose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>D-xylulose + ATP = D-xylulose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.17" evidence="7"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692722.1">
        <property type="nucleotide sequence ID" value="XM_006692659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4E8"/>
    <dbReference type="STRING" id="759272.G0S4E8"/>
    <dbReference type="GeneID" id="18256294"/>
    <dbReference type="KEGG" id="cthr:CTHT_0022560"/>
    <dbReference type="eggNOG" id="KOG2531">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016149_5_0_1"/>
    <dbReference type="OMA" id="NSCALGG"/>
    <dbReference type="OrthoDB" id="1728974at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004856">
        <property type="term" value="F:D-xylulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005997">
        <property type="term" value="P:xylulose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07776">
        <property type="entry name" value="ASKHA_NBD_FGGY_SpXK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000118">
        <property type="entry name" value="Xylulose kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042024">
        <property type="entry name" value="D-XK_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF57">
        <property type="entry name" value="XYLULOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 7" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="8">
        <location>
            <begin position="134"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="9">
        <location>
            <begin position="301"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS20426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="573" mass="62866" checksum="E4922814EF5A2D8D" modified="2011-10-19" version="1">MSNGPLYLGFDLSTQQLKAVVVQSDLQVVADAKVDFDQDFGAKYGIKKGVLHNHAEGEVFAPVALWLESLDLVLQRLKEKNTPLNRIRGISGSCQQHGSVYWSHQAQSLLAALKPEKALVEQLADAFSHPYAPNWQDHSTQQECDQFDVKLGSPERLAEVTGSAAHHRFTGTQIMRLKRKLPDMYANTSRISLVSSFLASLFLGAIAPMDISDVCGMNLWDIPSNDWSNPLLELAAGGPEGAAELRHKLGEVEKDGGASLGRISSYFTAKYGFSPNCEIAPFTGDNPATILALPLRPLDAIVSLGTSTTFLMITPVYKPDPSYHFFNHPTTPGQYMFMLCYKNGSLAREKVRDALPKPTDSPDPWANFNKAALAVPPLDVRSNSDRAKLGLYFYLPEIVPNIRAGTWRYTCNPTDGSDLQEETEEWPVETDARVIVESQALSMRLRSQNLVSKPDPSGKLPAQPRRVYLVGGGSLNPAIQSILADVLGGAEGVYKLDVGGNACALGGAYKAVWAFERVQGETFDELIGKRWKEEGAIQKVAEGYREGVFEQYGSVLGAFEEMEQRILKVAKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4Q0</accession>
    <name>G0S4Q0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nonsense-mediated mRNA decay factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0023110</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in nonsense-mediated mRNA decay.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692775.1">
        <property type="nucleotide sequence ID" value="XM_006692712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4Q0"/>
    <dbReference type="STRING" id="759272.G0S4Q0"/>
    <dbReference type="GeneID" id="18256349"/>
    <dbReference type="KEGG" id="cthr:CTHT_0023110"/>
    <dbReference type="eggNOG" id="KOG2162">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013363_0_0_1"/>
    <dbReference type="OMA" id="CCVRAPR"/>
    <dbReference type="OrthoDB" id="69928at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018834">
        <property type="entry name" value="DNA/RNA-bd_Est1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019458">
        <property type="entry name" value="Est1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF36">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10374">
        <property type="entry name" value="EST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10373">
        <property type="entry name" value="EST1_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telomerase activating protein Est1-like N-terminal" evidence="4">
        <location>
            <begin position="121"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/RNA-binding" evidence="3">
        <location>
            <begin position="202"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="627"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="752"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="791"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="894"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="627"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="797"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="825"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="903"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="937"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="968"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="988"/>
            <end position="1007"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU369098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS20479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1007" mass="109767" checksum="3195D1DEFCB7AADD" modified="2011-10-19" version="1">MASTSRTAESTRVPAGTAATVPVAPKTPAAEARMPSIDDIWKRAQKLRASLKKEIDHIQAEGHDGNLLQRFERLEELLANYRLRCIEVIWLDIRAANSKGAEDTLWAAHRMVIGAYRRALAQFFYKGYLQRIDARYEVKDLRRIVRKAGVEEMAPEASKIDPAAAQIEDIVRSSCHNTLTYLGDLARYRAQLHPKFPKFDNALAYYGLAIDLIPESGFAHHQCAAIFTELKDYLQVLYHLYRSLACEKPHPNAKKNLEVVFNTIRGLEATDAKNALVHWFLKLHASYYEGKEFTRRKALEQEVDNRMSMALKAGTGLDSDDTLLKMVLINICSCVTAHNSNLANWSEEGSRTYGFILLLNVRMIQAIAHVLGLEITDLLERNRETPPTKDGTTDTQRPETLFTAAFKRVLLLLRVYMAWLCSYGAELVEFQAYLAPHFGTMCTTLSNTLTLLFELLASNLELGKPVSWRFPEDEMTMSIKCLNGPHLRDGCQLYYDAFTRQPKPRREDVPSDNATDDDVIFTRILDVVCCTLALSDTGSRFPFNTSTMIKDSRQHTTVVYLAEGKPVPAATAQAQNALPATAAAGPVPIPATTVPAAVPVSLVPTSLTASAPPVQHPIPSNVATPAATQPVAPNTARLTPARLAVPPSPARSSKSNELSEDAEFYGPNLRTSSTPVGNPAAAVAAQYAQLSQAVASAKTPKPAPVVSEYPIENQLFQILNDFLAPPETARKSQPQTPSHVSAQTNPYTYASVTTAEEPPKSPPPGTSGAKPFPTLPWNFIINPEPVGSVMPGFSRPASSAHSLSHATHVRNGSRGSPGDLSSSSPQFGTAVPSNGRSSQSLQTYANIYGSRSTWISYQPNQHQLLASNDLAAIPSAAPRQNPWDAAAISFRTDTSQQGGTHYAVASSSDRAVPPSSSFSNLDLSSSSSSLPPVNSSWGLPTAQQQQRNASQGMTGAESLATQYALRSRPSEEQYRWEHSLGIGADGGLDSKEEVAKKAPDHDFQEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G0S589</accession>
    <name>G0S589_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0032660</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2018" name="Nature" volume="556" first="386" last="390">
            <title>Structural basis for ATP-dependent chromatin remodelling by the INO80 complex.</title>
            <authorList>
                <person name="Eustermann S."/>
                <person name="Schall K."/>
                <person name="Kostrewa D."/>
                <person name="Lakomek K."/>
                <person name="Strauss M."/>
                <person name="Moldt M."/>
                <person name="Hopfner K.P."/>
            </authorList>
            <dbReference type="PubMed" id="29643509"/>
            <dbReference type="DOI" id="10.1038/s41586-018-0029-y"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.75 ANGSTROMS) OF 98-866 IN COMPLEX WITH ATP</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="journal article" date="2018" name="Science" volume="360" first="552" last="558">
            <title>Structure of the DASH/Dam1 complex shows its role at the yeast kinetochore-microtubule interface.</title>
            <authorList>
                <person name="Jenni S."/>
                <person name="Harrison S.C."/>
            </authorList>
            <dbReference type="PubMed" id="29724956"/>
            <dbReference type="DOI" id="10.1126/science.aar6436"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (4.50 ANGSTROMS) OF 1-63</scope>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2022" name="Sci. Adv." volume="8" first="eadd3189" last="eadd3189">
            <title>Structural mechanism of extranucleosomal DNA readout by the INO80 complex.</title>
            <authorList>
                <person name="Kunert F."/>
                <person name="Metzner F.J."/>
                <person name="Jung J."/>
                <person name="Hopfler M."/>
                <person name="Woike S."/>
                <person name="Schall K."/>
                <person name="Kostrewa D."/>
                <person name="Moldt M."/>
                <person name="Chen J.X."/>
                <person name="Bantele S."/>
                <person name="Pfander B."/>
                <person name="Eustermann S."/>
                <person name="Hopfner K.P."/>
            </authorList>
            <dbReference type="PubMed" id="36490333"/>
            <dbReference type="DOI" id="10.1126/sciadv.add3189"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (4.68 ANGSTROMS) OF 98-866 IN COMPLEX WITH ATP</scope>
    </reference>
    <reference evidence="10 11 12" key="5">
        <citation type="journal article" date="2023" name="Science" volume="381" first="313" last="319">
            <title>Hexasome-INO80 complex reveals structural basis of noncanonical nucleosome remodeling.</title>
            <authorList>
                <person name="Zhang M."/>
                <person name="Jungblut A."/>
                <person name="Kunert F."/>
                <person name="Hauptmann L."/>
                <person name="Hoffmann T."/>
                <person name="Kolesnikova O."/>
                <person name="Metzner F."/>
                <person name="Moldt M."/>
                <person name="Weis F."/>
                <person name="DiMaio F."/>
                <person name="Hopfner K.P."/>
                <person name="Eustermann S."/>
            </authorList>
            <dbReference type="PubMed" id="37384673"/>
            <dbReference type="DOI" id="10.1126/science.adf6287"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS) OF 98-866 IN COMPLEX WITH ATP AND MG(2+)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693704.1">
        <property type="nucleotide sequence ID" value="XM_006693641.1"/>
    </dbReference>
    <dbReference type="PDB" id="6CFZ">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.50 A"/>
        <property type="chains" value="E=1-63"/>
    </dbReference>
    <dbReference type="PDB" id="6FHS">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.75 A"/>
        <property type="chains" value="J=98-866"/>
    </dbReference>
    <dbReference type="PDB" id="6FML">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.34 A"/>
        <property type="chains" value="J=98-866"/>
    </dbReference>
    <dbReference type="PDB" id="8AV6">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.68 A"/>
        <property type="chains" value="J=98-866"/>
    </dbReference>
    <dbReference type="PDB" id="8OO7">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="J=98-866"/>
    </dbReference>
    <dbReference type="PDB" id="8OOC">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.93 A"/>
        <property type="chains" value="J=98-866"/>
    </dbReference>
    <dbReference type="PDB" id="8OOF">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="J=98-866"/>
    </dbReference>
    <dbReference type="PDB" id="8OOK">
        <property type="method" value="EM"/>
        <property type="resolution" value="5.69 A"/>
        <property type="chains" value="J=98-866"/>
    </dbReference>
    <dbReference type="PDB" id="8OOP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="J=98-866"/>
    </dbReference>
    <dbReference type="PDB" id="8OOR">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.87 A"/>
        <property type="chains" value="J=98-866"/>
    </dbReference>
    <dbReference type="PDB" id="8OOT">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.85 A"/>
        <property type="chains" value="J=98-866"/>
    </dbReference>
    <dbReference type="PDBsum" id="6CFZ"/>
    <dbReference type="PDBsum" id="6FHS"/>
    <dbReference type="PDBsum" id="6FML"/>
    <dbReference type="AlphaFoldDB" id="G0S589"/>
    <dbReference type="EMDB" id="EMD-17006"/>
    <dbReference type="EMDB" id="EMD-17010"/>
    <dbReference type="EMDB" id="EMD-17012"/>
    <dbReference type="EMDB" id="EMD-17017"/>
    <dbReference type="EMDB" id="EMD-17025"/>
    <dbReference type="EMDB" id="EMD-17026"/>
    <dbReference type="EMDB" id="EMD-17028"/>
    <dbReference type="EMDB" id="EMD-4264"/>
    <dbReference type="EMDB" id="EMD-4277"/>
    <dbReference type="EMDB" id="EMD-7469"/>
    <dbReference type="SMR" id="G0S589"/>
    <dbReference type="IntAct" id="G0S589">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S589"/>
    <dbReference type="GeneID" id="18257304"/>
    <dbReference type="KEGG" id="cthr:CTHT_0032660"/>
    <dbReference type="eggNOG" id="KOG0681">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008246_1_0_1"/>
    <dbReference type="OMA" id="YPFTEHV"/>
    <dbReference type="OrthoDB" id="7340501at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0000305"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0000305"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0000305"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990758">
        <property type="term" value="P:mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990976">
        <property type="term" value="P:protein transport along microtubule to mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="CDD" id="cd10211">
        <property type="entry name" value="ASKHA_NBD_Arp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000087">
        <property type="entry name" value="Actin-like ATPase domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000139">
        <property type="entry name" value="Chromatin remodeling complex subunit (Arp5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.36.70">
        <property type="entry name" value="Actin, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013959">
        <property type="entry name" value="DASH_Dad4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08650">
        <property type="entry name" value="DASH_Dad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6 7 8" id="KW-0002">3D-structure</keyword>
    <keyword evidence="7 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="69"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="608"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="404"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="73"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8 9">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 11 12">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 11 12">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8 9">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 11 12">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 11 12">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 11 12">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12 13">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8 9">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 11 12">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 11 12">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8 9">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13 14">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 11 12">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 11 12">
        <location>
            <position position="788"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS21408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="6CFZ"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="6FHS"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="6FML"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="8AV6"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="8OO7"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="8OOC"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="8OOF"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="8OOP"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="8OOT"/>
        </source>
    </evidence>
    <sequence length="866" mass="98435" checksum="D680AD47BC61A158" modified="2011-10-19" version="1">MESPHEHQQNLLLSRIITNVEKLNEAIMVMNKTLQEINIQNMNIELVAQMFKNYQSNVLFHLEEYQPKPNPPSSLIASTPTTSPSSSSSSSSSSSSTMAPSAVAEPPPIPQRDEPWKRLPPPTVYPVKEARFEKYIPPQLDGRERALAQPPGQVAIVIDNGSHSVRAGWNFEDKPRLAIPPIMSKYRDRKMGKTFSFAGSDCYADTTARSHIRNAFEAGTGIVSNWDVMEHVLDYVFVKLGMNECDGAIDMPIVMTEAVANLPYSRKSMSEIIFECYGAPSLVYGIDSLFSFRHNQGQTGLVVSSSYSATHVIPVYNRKALLSQAIRLNWGGWHMAEYMLKLLKLKYYTGFPGKLNSSQTEHMVRDFCYVSLDYDRELAGYLDWTGLEDRERIVQYPYTEEVVVQKTEEELARIAERKKESGRRLQEQAAKMRLERLMKKEQELEYYKDIQRRMQGESKKEIKRLLDEAELKDEAALERVIRDLERSIKRARQKDLGEPEEEEVPDFSLLDVPDDQLDEAGLRQKRQQRLLKSNWEARQRAKAEKEAEKARLAEEARLDEERRKNDLEGWLEEKRQLRLAKLNQLKERERLKADLGNRKSLASQIRMKNIANLASDNPTGSGSRKRRRGGAGADQDDDFGADDADWGVYRSVAIGANKGDDSDDEEGEEDLEAAIRSLENDLLRYDKTFSYDMTLDAQRDWSKSLLHAFRYGPRPFDPSSQAETHRVHLNVERIRVPEVLFQPAAIAGVDQAGLVEIAGDILCQRLPSLPGIQDAPDAFLRDVFLTGGNTLFQNFDERLRQGLMALLPVGAPLRVRRAQDAILDAWRGAAGWACTEEAKAAWITREEYLEKGGEYIKEHDLGNAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5C6</accession>
    <name>G0S5C6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiamine biosynthetic bifunctional enzyme-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0024330</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692895.1">
        <property type="nucleotide sequence ID" value="XM_006692832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5C6"/>
    <dbReference type="GeneID" id="18256471"/>
    <dbReference type="KEGG" id="cthr:CTHT_0024330"/>
    <dbReference type="eggNOG" id="ENOG502SP43">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090736_0_0_1"/>
    <dbReference type="OMA" id="PHFGTLC"/>
    <dbReference type="OrthoDB" id="3890746at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="218" mass="23737" checksum="A700EFBDCD239314" modified="2011-10-19" version="1">MHLFTKPSSTSSSSSSVTCDAQIQSKRHTLRTLSFALMGTASLGLLLGLSILGLAANTLRIYDDTNLGPQYFLPLWPRDTDLKPTIGYIVAGSLAVVGNVFVVGFGRANFRPSTSRTAISLLPPLLALSGILTALGLHYASLPSVNRPDTIVSWACRWNDVPMKVQPKWGEICRQGRSASYVALVTLPVEVVVLGLVWIVEKVRSDVWEVENREKGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5K9</accession>
    <name>G0S5K9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">26S proteasome regulatory subunit RPN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0033320</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proteasome subunit S2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693770.1">
        <property type="nucleotide sequence ID" value="XM_006693707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5K9"/>
    <dbReference type="STRING" id="759272.G0S5K9"/>
    <dbReference type="GeneID" id="18257370"/>
    <dbReference type="KEGG" id="cthr:CTHT_0033320"/>
    <dbReference type="eggNOG" id="KOG2005">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008705_1_0_1"/>
    <dbReference type="OMA" id="GTCNGDI"/>
    <dbReference type="OrthoDB" id="10252509at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000026">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016643">
        <property type="entry name" value="26S_Psome_Rpn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041433">
        <property type="entry name" value="RPN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040892">
        <property type="entry name" value="RPN1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18051">
        <property type="entry name" value="RPN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17781">
        <property type="entry name" value="RPN1_RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015965">
        <property type="entry name" value="26S_Psome_Rpn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 9" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RPN1 N-terminal" evidence="7">
        <location>
            <begin position="60"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit RPN1 C-terminal" evidence="8">
        <location>
            <begin position="845"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00057191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR015965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS21474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="902" mass="100664" checksum="C54CC0A376EE2645" modified="2011-10-19" version="1">MAQDSDLSKSPDMGKGKAVDSGRKAEAQKDKPVANGKKGDEKSESSEELSEEDQQLKSELDMLVERLTESDATLYKPALEAMKTFIKTSTSSMTAVPKPLKFLRPHYETLTKLYDQWPAGDDKNSLADVLSVIGMTFSDEERQDTLKYRLLHPKGDIAGWGHEYVRHLALEIGEVYQKRIAADEPTQDLVDLALILVPLFLKANQEADAVDLMSELEIIEELPRFIDENTYRRACLYMVSMVNLLTYPENEQFLRVAHSIYKTYKQYTQAMVLAIRLNDIDLIWSDFQEAPDPALKKQLAFLIARQRICLEIPRETPEDEEIFECLGNVKLSEYFKTLGKELNILEPKTTEDIYKSHLENSRVAGMTNFDSARNNLAAAFVNAFVNAGFGNDKMMLVNQDKESWVWKTKEEGMMSTVASLGTLLLWDIENGLDQVDKYTYLEEEQIQAGAYLAIGIMNSGVRLDSDPAMALLADNDKLNHKNPLIRVAAIMGLGLAYAGSNKDELLPFLLPIIIDTSQEMRVSAMAALACGIIFVGSSHPEVSEAIITTLLDDDRKSQLTDKWTRFLALGLGLLFFGRQEEVEVILETLKAVEHPMAKPTSVLASICAWAGTGAVLKIQELLHLCNEHMEESDEKKGDELLQAYAVLGIGLVAMGEDIGQDMVLRHFGHLMHYGEANIRRAVPLAMGLVSPSNPQMKVYDTLSRYSHDNDNDVALNAIFAMGLLGAGTNNARLAQLLRQLASYYARDQESLFMVRIAQGLLHMGKGTMSISPFHTDRQILSRVSAAGLLTVLIAMIDAKQFITSKSHWLLYFLITAMHPRFLITLDENLKPVTVNVRVGQAVDVVGQAGRPKTITGWQTQSTPVLLAYGERAELEDDEYISLSNTLEGLVILRKNPEWDGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0S605</accession>
    <name>G0S605_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0025570</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693017.1">
        <property type="nucleotide sequence ID" value="XM_006692954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S605"/>
    <dbReference type="STRING" id="759272.G0S605"/>
    <dbReference type="GeneID" id="18256595"/>
    <dbReference type="KEGG" id="cthr:CTHT_0025570"/>
    <dbReference type="eggNOG" id="ENOG502RN59">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008451_0_0_1"/>
    <dbReference type="OMA" id="PQSLKSW"/>
    <dbReference type="OrthoDB" id="46189at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033370">
        <property type="entry name" value="COG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="745"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS20721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="840" mass="91974" checksum="282B89ABCE9614F3" modified="2011-10-19" version="1">MAPTATTLPQGLDIALLRSSHELFSTAPFSALDPTSTTSSTSTTPVPPSKHLPGQPYTLPQIRAIHAALQTRAADIQSRLRTQVGASYRDLLGTADTIVAMRTEMDKAVGLLGAMGARCGAGVVSEKVKGLKEFTAAHAGKNIYGGKDLGVAAREKLLAGCLLGLREILGGGSYKADTSRKKKKSGDELLRAARLYVLAKLLVQSLSGTGSTDAASARKSLENVHSPRLRSHIAAVLRSASDGPMRCGDVLKALGAHSLAETAGARDVLRYFLRVRSEAIALALDVNKDEDDGNETKQSADVTRALGLYAKTLLDVQSLVPKQLPDALHALKQDRLLENSLLKDMECLRLDIYKQWCGDEIQFYIPFIRHDDLEPSQAREMLLSWARSGSEVLLKGLNRTLERMTELKAIVELRTNVLKLWVAEGSKVRGIDQSTMLNELREVINNHMLRVLEAKVSKLRLVGSEVAATLSSWREGVTDQHTSLWDDVTALDTDLTTPNGAVDFTQAVIGRMHGCSDVVSKAIACYRSWFRVIEDAGRVVDTLRRQRWENDVDDLVEDEETIEERQQLLTRDDPAALSNHLTHLLAKAFGKLSEQLSSLWDAQKEGPNSGAVAAYLLRVLRDIRARLPDHELEKLEQVKNFGLAMVPSLHEALAKAVSVGPLDELSTVTLTRRTVAGRALWEGEPELPCSPSPGAFKFLRNLTVAMRDAGADLWSLAAVAVLKKHLVPEISKAWVEALEGLSSNDNNAQVGESGGEKGSAGEKESNNVTSIEVHHDLLVQWLLDIHYLRLFLGPSEELFKELEDAVWKKTALDKTAIETRLAKTSQDYHKRTTLLFGLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0S623</accession>
    <name>G0S623_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative amino acid sensor-independent protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0033910</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693827.1">
        <property type="nucleotide sequence ID" value="XM_006693764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S623"/>
    <dbReference type="GeneID" id="18257429"/>
    <dbReference type="KEGG" id="cthr:CTHT_0033910"/>
    <dbReference type="eggNOG" id="ENOG502QV7Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006057_0_0_1"/>
    <dbReference type="OMA" id="ERMNVTP"/>
    <dbReference type="OrthoDB" id="66726at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16616">
        <property type="entry name" value="mRING-HC-C4C4_Asi1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22696">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22696:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="448"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="635"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="666"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="791"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="801"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS21531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1024" mass="112465" checksum="DA8FCE449F1D3604" modified="2011-10-19" version="1">MADVLVAEEAAATATSRPLEFVNAWHNFTLWTTQHLGIAMNISRLAPSLEDLVWAGPRMVMKLGKFGGSFISFPDAIDVFGQRVSSSLADPNMFAMESSSSAVPMAQIESFVESVSFSSPSSVVSAAAAAATATQDQSSSNSGFSLESSRGIGTFFSYATSKWALCCVAMAVIINRTHVFAATRRRLVLRWPLRLLLRIGPIVLLLIQVRSLLQSIQCQTSPDFAQLRWGNANKSSELMFAFPNSVLNQLSSALLLGASDQESCRSVRMIPWDSHQQPELVGSLSKLWPLFATFCFSQFVEVLSCVLQGRPVAAETGMTLFEHSLAFAEAEAAVGNQLGWSLFTNKSTISQGSSLGGSAVALTRSMIMKRVNTSPEVLFVAFISAMSHITSHILGLFNLQSKFRLISTGFWGLCFMAGIFLSALNFSLDDPSAQGLLRFPTVCIVGFIPHILVLAGIWACAVVYVTALLLSALAMPSSGEDGHRLSLRQRLVRAHANMQTNISLSDIRIRTDMDFYSALLRAGFGAITMASEAVYLNEDRCVELKRCTWLEEDRLREMEEMRMQWIAGGVPGSRFDEVGAIGLVPIKNGQANATSGYARERAAQQIPKNNASGRRIRDGVGASERSSRWLMAVEYVLHVGRLLIVTWALCTVKILTVFGVRTPPRWLQGLSQRPKPESREKRRSGRRERGLNVDVLSPGEGKSFITIPRTDQVDVEAELRRHMVPNSADATNQNNPPIDEEEVDFKLYSYFLRGGWWGANDSSGDYVPPSPQGTDINDPDFDTTSVVSTTETTIDSELDWESDHGDNDALDDGQRTPTQRDHVPLSFAEALVSARASRESTPVVDTPISPADLARLLNPQSPEDREEARTLAAHLTSDGIMTRSRFRQYLQRQRAQILLTGNYSYLSQPSQSNRKPIIVEKMTPEEEACRLEELLLSRRRAAAAAKASASKETAGSSWATGAEGLGPDGPQCVVCQSAPRTIIVWPCRCLSLCDDCRVSLAMNNFDKCVCCRRDVISFSRIYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G0S658</accession>
    <name>G0S658_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0034270</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit APL3 and beta-type subunit APL1), a medium chain (mu-type subunit APM4) and a small adaptin (sigma-type subunit APS2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693862.1">
        <property type="nucleotide sequence ID" value="XM_006693799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S658"/>
    <dbReference type="STRING" id="759272.G0S658"/>
    <dbReference type="GeneID" id="18257465"/>
    <dbReference type="KEGG" id="cthr:CTHT_0034270"/>
    <dbReference type="eggNOG" id="KOG0935">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061221_3_2_1"/>
    <dbReference type="OMA" id="QSNFVEY"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14833">
        <property type="entry name" value="AP2_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000011">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027156">
        <property type="entry name" value="APS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0168">Coated pit</keyword>
    <keyword evidence="6" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="13">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS21566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="143" mass="16899" checksum="5F24B7FC8D92C651" modified="2011-10-19" version="1">MLSFILIQNRQGKTRLAKWYVPYTDEEKIKLKGEIHRLVAPRDQKYQSNFVEYRNLKVVYRRYAGLFFCAGVDTNDNELAYLEAIHFFVEVLDAFFGNVCELDLVFNFYKVYAILDEVFLAGEIEETSKQVVLTRLEHLDKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6K0</accession>
    <name>G0S6K0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4211 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0026490</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
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                <person name="Hurt E."/>
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            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
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        <property type="protein sequence ID" value="EGS20811.1"/>
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    <dbReference type="OrthoDB" id="21499at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="DUF4211"/>
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        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 82"/>
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    </dbReference>
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        <property type="entry name" value="DUF4211"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="313"/>
            <end position="449"/>
        </location>
    </feature>
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            <begin position="24"/>
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        </location>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
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    </evidence>
    <sequence length="591" mass="66726" checksum="A4604763FD7D511B" modified="2011-10-19" version="1">MAAAKRSMKQQTLEATFGRSIVKSKQQGGNEHICSTAKNNSAAVVQSSSPLPPSSSMNFSFMGSSQLASARKKMFVVRDVSSEDSSESENEPEVSVEMSIDAPNDENKGNGSSSSSKSSSDDSDEESEAKLPFRRIQRTKRRISTSSSEAADNNDNKIASGRPEKPIVDDTDDDDDKPLQRPATKRRRLVCRNSVQAQNTSNEDNDENEDEEQPELRVITRRTRSARRPLTAKAKALERLRRKKAGQAVDDDESSSEEEERKPLYDYDPDHMALQEFPDDEEGVIQLNVDNQSKENHRKKRSGDDDSAGDMDDFIDDDSDQPIGFPEDVEIPMQFSKWATQPLKFHFKIVIEWLIKFKLNPGFKRDMPIYQIAWRKIDDEVQGLSHSKFSSSVWRVDFSKALRARPYIETHEIPKNDAARITTCDACGRTNHPASWVISFKGAAYHKKTGDLTRFLEPVKAESSDNGGESDEDSDVDWDEDEDGNDIPKATKQWFVGANCSANAETSHTLLHWKINLLNWVDTRLSEEGHMTPAKVAERKRMSAAKREEVTYEVVNTWMNSQIVSKLYREFKAHLEEARNRSTKGRAHHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6L2</accession>
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        <submittedName>
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        <name evidence="2" type="ORF">CTHT_0026610</name>
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    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
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            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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        </lineage>
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        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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    <dbReference type="STRING" id="759272.G0S6L2"/>
    <dbReference type="GeneID" id="18256699"/>
    <dbReference type="KEGG" id="cthr:CTHT_0026610"/>
    <dbReference type="eggNOG" id="KOG3171">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053880_1_0_1"/>
    <dbReference type="OMA" id="RVHYADI"/>
    <dbReference type="OrthoDB" id="70588at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008277">
        <property type="term" value="P:regulation of G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosducin"/>
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        <property type="entry name" value="Phosducin-like_reg"/>
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        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
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        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052:SF1">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
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            <end position="83"/>
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            <end position="149"/>
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            <end position="40"/>
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            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="283" mass="32947" checksum="A7A46F1C761EDA21" modified="2011-10-19" version="1">MALNLTPAQEEFQLFLEKNNRSELDKYHPEDREDIIREREEESQDEEDEYRQKQIEAAMRMPTLDHRNEIRLPPPSFDHGRTTGVKGVIADARAYEAARHSRWKEKVRAARRSVFSLDRGSSRRDRVTSSDEDEDSDPGHTLTADDLDEDEFMRQWRETRRRELEQESRNPIRNRRTSPSVRMYGRFDHVDALGYLDAIEKCDVSAMIEAALSPLVRAYPAVHFVKVHYLDLEFEPAGVPAILAYRNQGDLFVNLTGILELIPDEDEFDTDALKKLFIEKGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6X9</accession>
    <name>G0S6X9_CHATD</name>
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        <recommendedName>
            <fullName evidence="12">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0027250</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
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        <property type="protein sequence ID" value="EGS20887.1"/>
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        <property type="nucleotide sequence ID" value="XM_006693120.1"/>
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    <dbReference type="KEGG" id="cthr:CTHT_0027250"/>
    <dbReference type="eggNOG" id="KOG1607">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OMA" id="LCRLCML"/>
    <dbReference type="OrthoDB" id="3053196at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF11">
        <property type="entry name" value="CERAMIDE SYNTHASE LAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="367"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="12">
        <location>
            <begin position="184"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="406"/>
            <end position="439"/>
        </location>
    </feature>
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        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
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        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="424"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS20887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="439" mass="50669" checksum="B76B4D2262F23B44" modified="2011-10-19" version="1">MMAADSEPFPPLATDRQLHSATADSGARRRRKSSILGSQLNVGDTGAPALSTSLAQLNGTPKESPAGFTSPSKRFSKRRKARSLLRRAKSIIVKHTWVLPLVILFTFLFLYALNPTESNPVHHFIFLSYRLPITNPNEPPQYGKGPWDIAFVTFYTVVLSFTREFIMQEILRPMARWAGVKSKTKQARYMEQMYTALYFGILGPTGMYVMSRTPVWYFNTRGMYENFPHKTHDALFKFYYLFQAAYWAQQAIVLILGMEKPRKDFKELVGHHIVSLALIALSYRFHFTYMGLAVYITHDISDFFLATSKTLNYLDHPLTGPYYFTFMCVWIYLRHYINLRILFSLFTEFKTVGPYELNWETEQYKCWISFTITLLLLGALQCLNLFWLFFIIRIAYRFVVHNIAKDERSDGEESETEETSSSSNGKPVTANGNAKKSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0S743</accession>
    <name>G0S743_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spliceosomal protein DIB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0027370</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DIM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693194.1">
        <property type="nucleotide sequence ID" value="XM_006693131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S743"/>
    <dbReference type="STRING" id="759272.G0S743"/>
    <dbReference type="GeneID" id="18256775"/>
    <dbReference type="KEGG" id="cthr:CTHT_0027370"/>
    <dbReference type="eggNOG" id="KOG3414">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117348_0_0_1"/>
    <dbReference type="OMA" id="GMYELYD"/>
    <dbReference type="OrthoDB" id="147752at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02954">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000004">
        <property type="entry name" value="Spliceosomal protein DIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004123">
        <property type="entry name" value="Dim1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052:SF5">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEN 4A, 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02966">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017199">
        <property type="entry name" value="mRNA_splic_U5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01410">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="39"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR017199-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS20898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="143" mass="16721" checksum="2B2E6373E55F949D" modified="2011-10-19" version="1">MGSVLLPHLPSGWHVDQAILSEEERVVVIRFGRDHDPDCMRQDETLYKIAEKVKNFAVIYLCDIDQVPDFNAMYELYDPCCIMFFFRNKHIMCDFGTGNNNKLNWVLEDKQELIDIIETVYRGAKKGRGLVVSPKDYSTRHKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G0S758</accession>
    <name>G0S758_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0027520</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693209.1">
        <property type="nucleotide sequence ID" value="XM_006693146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S758"/>
    <dbReference type="GeneID" id="18256790"/>
    <dbReference type="KEGG" id="cthr:CTHT_0027520"/>
    <dbReference type="HOGENOM" id="CLU_2704597_0_0_1"/>
    <dbReference type="OrthoDB" id="2587363at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="73" mass="7888" checksum="D7424986E5DDB64C" modified="2011-10-19" version="1">MGHSKKMGPTAFGGRPTWHESRTFYTCTDITFVDASQFNPASVPCFNATDSENDVPPPTTTGTPTNLPDHGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7C9</accession>
    <name>G0S7C9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyltransferase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0036400</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694069.1">
        <property type="nucleotide sequence ID" value="XM_006694006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7C9"/>
    <dbReference type="STRING" id="759272.G0S7C9"/>
    <dbReference type="GeneID" id="18257678"/>
    <dbReference type="KEGG" id="cthr:CTHT_0036400"/>
    <dbReference type="eggNOG" id="ENOG502SHP9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005679_13_3_1"/>
    <dbReference type="OMA" id="GWERHYY"/>
    <dbReference type="OrthoDB" id="5819582at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF125">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="34"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS21773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="478" mass="55647" checksum="DA218E53BA4C06EE" modified="2011-10-19" version="1">MISIFGALRGLRQLLWPKSSASVPDEPKKLRPTAYLDGLRGFAALLVFIQHHEEWAHCFSIPIFEGGFGYRGNYYFATFPWVRMLFTGGHAAVATFYIISGYVLTWKPLSLIHAGEHLKLFDSLASAFFRRWFRLYIPLIVTTFFWITSWHVFNYWNAACEPKATYREELWNWYNEMKNFSFLFKDGGMVWVTFNTHLWSIPLEMRGSMVVFISCITLARATTKARLLAELVLMFYFLYIVDGYYLALFLSGMMQCELDLLAKKDGWFPGFLRRLEPRKTLLYYLGLFVALYIAGVPSEKAEVEYLREQPGWYYMSYLTPSAMYDHKWIYLFFSCNIIMAAIPRIGWLKRFFESRFCQFLGYVSFAFYLVHGPILASIGDRVYYAVGWTRPPNDRHEQVAHWANLFPLPKKGPMGLEIAFLVPNLLVLLPFTLWVANIVTRMVDEPAVKFAAWLYKRVQGGGSQEPKPVELAPLMRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7D7</accession>
    <name>G0S7D7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0036490</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694077.1">
        <property type="nucleotide sequence ID" value="XM_006694014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7D7"/>
    <dbReference type="STRING" id="759272.G0S7D7"/>
    <dbReference type="GeneID" id="18257687"/>
    <dbReference type="KEGG" id="cthr:CTHT_0036490"/>
    <dbReference type="eggNOG" id="ENOG502S0RT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_361294_0_0_1"/>
    <dbReference type="OrthoDB" id="4589621at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="774" mass="85506" checksum="21B9B5BC0926FB16" modified="2011-10-19" version="1">MANLPPRPVFTNLDNVLDSGSRPHFNSLQGKQQVSRSDFHPYSRPAKTPDGSSIIPPWRVRRGICPSQMTAFPGASITSWRAQQCNYHQNRVGRDMPIPNYPPAGWTQPSPSGFPMRSPALNTNAYGSEALPSSGRGRGAYGDSPFAYQAALPMRQEQFRSYHPPSWPGQNNVSSMMTNSIHPTNVATCPHHLAGWNTEMGPRSVPLASTPFQRRGSMVRSDLTSRSVSPMSLSSARMAPEQIVVNVNRSSIDRRVCDPMNLDQSRSGTATPSSRSSLDHTGVLGQHGHPIVAPNTPIRRSPFASVSRRPTNFSMNDQHLLRNLNSAASQLYANGSPNYTSFQRPDETTSAINLTMEDYQAQQMAAIHHDSVSVVHGDNQPEIPAIALSPNPDTTLFVTCGTETRKLLIKSDALSIFKVFERLADSNRHYLHIDLCRVLIDPTKETLPPYFEPEPHLAAFQTLLDVIHNPKMDVRGIFTPNKLCQLGHLNNPSVAGVGSGPGLGINEPWADWLRAHMKKFVEHVRRLCALGESKSTFLWLAGPSFKHSWDKDMKDKALEKALEACRAFRWAKEFRELVASTAYLCAVDPDSKETGETVLVRPDGAKLEESICGRDVVEIIVNTRKRVADQFFKAAQASLTRWTVQLGRRPCKNQLCTSGRMAALNNFLLVSGLFPRGDLPKSLFEIITGLRYLTASDAELASVSQQQRGPVVGGEAAPGLEWAVQMRVKHVAVCTKCDERAPTSTLFPLEDLLVDLTWELQERLLEAAARAECA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7L0</accession>
    <name>G0S7L0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0036700</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694097.1">
        <property type="nucleotide sequence ID" value="XM_006694034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7L0"/>
    <dbReference type="STRING" id="759272.G0S7L0"/>
    <dbReference type="GeneID" id="18257708"/>
    <dbReference type="KEGG" id="cthr:CTHT_0036700"/>
    <dbReference type="eggNOG" id="KOG0027">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061288_13_1_1"/>
    <dbReference type="OMA" id="HDQASTN"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="72"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS21801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="139" mass="15599" checksum="8D96787ED23385B7" modified="2011-10-19" version="1">MASTNYKEAFSLFDTRGVGRVSLDKLGDLLRACGQNPTLAEIRELEKSIGGDFDFETFQRILNRPGGFRDPGEPEEYCRGFQVFDKDMTGFIGVGQLKYILTNLGEKMTEEEVDELLKAVDTSNGQVNYTELVRTILSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7T3</accession>
    <name>G0S7T3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0028730</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2010" name="FEBS Lett." volume="584" first="1509" last="1514">
            <title>The structure of Get4 reveals an alpha-solenoid fold adapted for multiple interactions in tail-anchored protein biogenesis.</title>
            <authorList>
                <person name="Bozkurt G."/>
                <person name="Wild K."/>
                <person name="Amlacher S."/>
                <person name="Hurt E."/>
                <person name="Dobberstein B."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="20206626"/>
            <dbReference type="DOI" id="10.1016/j.febslet.2010.02.070"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.98 ANGSTROMS) OF 2-329</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GET4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693329.1">
        <property type="nucleotide sequence ID" value="XM_006693266.1"/>
    </dbReference>
    <dbReference type="PDB" id="3LPZ">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.98 A"/>
        <property type="chains" value="A=2-329"/>
    </dbReference>
    <dbReference type="PDBsum" id="3LPZ"/>
    <dbReference type="AlphaFoldDB" id="G0S7T3"/>
    <dbReference type="SMR" id="G0S7T3"/>
    <dbReference type="STRING" id="759272.G0S7T3"/>
    <dbReference type="GeneID" id="18256911"/>
    <dbReference type="KEGG" id="cthr:CTHT_0028730"/>
    <dbReference type="eggNOG" id="KOG3024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046061_0_1_1"/>
    <dbReference type="OMA" id="LMDMMGM"/>
    <dbReference type="OrthoDB" id="10252405at2759"/>
    <dbReference type="EvolutionaryTrace" id="G0S7T3"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000272">
        <property type="entry name" value="DUF410 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007317">
        <property type="entry name" value="GET4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875:SF0">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04190">
        <property type="entry name" value="GET4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="3LPZ"/>
        </source>
    </evidence>
    <sequence length="329" mass="36342" checksum="EE4DB4DBB8185557" modified="2011-10-19" version="1">MSNKIERIIARLQRRIAEGQPEEQYEAAQETRLVAARYSKQGNWAAAVDILASVSQTLLRSGQGGSGGDLAVLLVDTFRQAGQRVDGASRGKLLGCLRLFQPGEPVRKRFVKEMIDWSKKFGDYPAGDPELHHVVGTLYVEEGEFEAAEKHLVLGTKESPEVLARMEYEWYKQDESHTAPLYCARAVLPYLLVANVRAANTAYRIFTSALVEDNKGLTVQNIGSQSAELRIFPSLPLLNFISMLLLSVQKGSPDLFRQLKSKYEANLNELNGIWDTALELIAEMYFGIQRPRQSNPLLDMMGSLFGGGGGAPSKAALRRIDTPAAEGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7Z9</accession>
    <name>G0S7Z9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pyruvate decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0037590</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694182.1">
        <property type="nucleotide sequence ID" value="XM_006694119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7Z9"/>
    <dbReference type="STRING" id="759272.G0S7Z9"/>
    <dbReference type="GeneID" id="18257797"/>
    <dbReference type="KEGG" id="cthr:CTHT_0037590"/>
    <dbReference type="eggNOG" id="KOG1185">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_4_0_1"/>
    <dbReference type="OMA" id="HNGWSKD"/>
    <dbReference type="OrthoDB" id="10006023at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="5">
        <location>
            <begin position="21"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="4">
        <location>
            <begin position="507"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="405"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="414"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS21886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="664" mass="71894" checksum="9BA9D8878995EBE1" modified="2011-10-19" version="1">MSSALLIPAANNSSADLPLFGSDAIIDVLSELGVLYIAFVPGSCFRGLQDSIINYKYDRQPEVVVCLLEDHAIAIAHGFTKVLPTSPMAAAVRDGVGLMNAFVAIDNAHLDRVGFPILGGKEHLDSTRRNLQADGMQKTVDEAAPIKPLKFYDRPVSLQGALQSIITAFTTAVQVPRSPTYVCLGASLQEERIPVPLVHNLPKVSRYLDTVRNSPRPARVDVQRVQEALLASPPDGRLFLYGRVGRSLSSWSQRISLAAKYKAHVLTDLKLPSAFPTPHPLHPVTPSLLLDEDAIQIIRASEIIIAFNWVDLSGTLRTAFSETSGEPPQTVCVVSVTLEQPSPCNYWSKNAAQPPVDIAVHADVDKFIEELLVAPETVPIDATSQSTHQNHDHVASQHLIPETKPIKIKTGRNSTSNSSGMDASSSSSLWRRRASGSSQPSPLSPLTPMGIAFSTLNMRDTPQITLRDLAVAFYKVLTPASISFLRLPLNWPRNELIQMHPFAHLGHYGESRTGLGPGYAVGAALALKHLGRSPHNLIPIAVLDDGDFLAGCQALWTAANKKVPMLVVVMNSRVFGDDQRAKKAIANGRGRVTQNKSGNVLLAEEPLVDVMTIAEGFGCTRGSRFQVARRKELEGVLHASAELVRHGKVVVLDVLVKSGEEASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8B7</accession>
    <name>G0S8B7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-ornithine N(5)-monooxygenase [NAD(P)H]</fullName>
            <ecNumber evidence="4">1.14.13.196</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0021170</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-ornithine + NADH + O2 = N(5)-hydroxy-L-ornithine + NAD(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41512"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-ornithine + NADPH + O2 = N(5)-hydroxy-L-ornithine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41508"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.196" evidence="4"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692588.1">
        <property type="nucleotide sequence ID" value="XM_006692525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8B7"/>
    <dbReference type="STRING" id="759272.G0S8B7"/>
    <dbReference type="GeneID" id="18256155"/>
    <dbReference type="KEGG" id="cthr:CTHT_0021170"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020931_2_0_1"/>
    <dbReference type="OMA" id="SFAMYLK"/>
    <dbReference type="OrthoDB" id="3519933at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025700">
        <property type="entry name" value="Lys/Orn_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802:SF1">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13434">
        <property type="entry name" value="Lys_Orn_oxgnase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS20292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="491" mass="54415" checksum="381FDCFE7798F0E7" modified="2011-10-19" version="1">MSPHIDTENGVNGHEPVPELVPAVPGPVSTPSVAPEPTARQFPKSTYLKPAPEDAVLDLLGVGFGPACISIACALHDTLEKGKLPAQPNVLFLEKQSEFNWHAGMLLPGTKMQISFIKDLASLRDPRSNFTFLNYLHKNDRLLDFINLNTFTPARAEYEDYLRWCARHFDDVVHYQTEVVSITPVEADRPAKTFEVTARDLRTGAVKTYRAKNVVVALGGQGYLPEVFPRNHPRIIHSSQFAYTVPKLLADRNAPYRIAVVGGGQSAAEIFMNLQNTYPNCKTYMVVRADFLRPSDDSPFINGIFNPEFIETFYPQSSASRARLLADAKATNYSVVRLELIEALFEVMYHQKRTLGSDERVWPHRILSGRHILSVEDSPNGGVHLKLEGGAGNDGPVEEIEVDMVVCATGYERKAHLELLKGVYNLLPEVDGSKLSEAERKDRWVVETGKGSTTTSRVMQVGRDYAVRFAEQAVAPGSGVWLQGCNEATHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8G4</accession>
    <name>G0S8G4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Putative ribosomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CTHT_0029790</name>
    </gene>
    <organism evidence="23">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="24 25" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="476" last="476">
            <title>High-resolution structures of a thermophilic eukaryotic 80S ribosome reveal atomistic details of translocation.</title>
            <authorList>
                <person name="Kisonaite M."/>
                <person name="Wild K."/>
                <person name="Lapouge K."/>
                <person name="Ruppert T."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="35079002"/>
            <dbReference type="DOI" id="10.1038/s41467-022-27967-9"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.90 ANGSTROMS) OF 593-720 IN COMPLEX WITH ZN(2+)</scope>
    </reference>
    <reference evidence="26 27" key="3">
        <citation type="journal article" date="2023" name="Nat. Struct. Mol. Biol." volume="30" first="670" last="677">
            <title>Structural inventory of cotranslational protein folding by the eukaryotic RAC complex.</title>
            <authorList>
                <person name="Kisonaite M."/>
                <person name="Wild K."/>
                <person name="Lapouge K."/>
                <person name="Gese G.V."/>
                <person name="Kellner N."/>
                <person name="Hurt E."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="37081320"/>
            <dbReference type="DOI" id="10.1038/s41594-023-00973-1"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.20 ANGSTROMS) OF 593-720 IN COMPLEX WITH ZN(2+)</scope>
    </reference>
    <reference evidence="28" key="4">
        <citation type="journal article" date="2024" name="Nat. Commun." volume="15" first="716" last="716">
            <title>Methionine aminopeptidase 2 and its autoproteolysis product have different binding sites on the ribosome.</title>
            <authorList>
                <person name="Klein M.A."/>
                <person name="Wild K."/>
                <person name="Kisonaite M."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="38267453"/>
            <dbReference type="DOI" id="10.1038/s41467-024-44862-7"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.10 ANGSTROMS) OF 594-720 IN COMPLEX WITH ZN(2+)</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the 60S subunit of the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="19">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. eL40 is essential for translation of a subset of cellular transcripts, including stress response transcripts, such as DDR2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Part of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RRN7/TAF1B family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693434.1">
        <property type="nucleotide sequence ID" value="XM_006693371.1"/>
    </dbReference>
    <dbReference type="PDB" id="7OLC">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="Lm=593-720"/>
    </dbReference>
    <dbReference type="PDB" id="7OLD">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="Lm=595-720"/>
    </dbReference>
    <dbReference type="PDB" id="7Z3N">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="Lm=593-720"/>
    </dbReference>
    <dbReference type="PDB" id="7Z3O">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.30 A"/>
        <property type="chains" value="Lm=593-720"/>
    </dbReference>
    <dbReference type="PDB" id="8OO0">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="Lm=594-720"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8G4"/>
    <dbReference type="EMDB" id="EMD-12976"/>
    <dbReference type="EMDB" id="EMD-12977"/>
    <dbReference type="EMDB" id="EMD-14479"/>
    <dbReference type="EMDB" id="EMD-14480"/>
    <dbReference type="STRING" id="759272.G0S8G4"/>
    <dbReference type="GeneID" id="18257017"/>
    <dbReference type="KEGG" id="cthr:CTHT_0029790"/>
    <dbReference type="eggNOG" id="KOG0003">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016553_2_0_1"/>
    <dbReference type="OMA" id="ICRDIWA"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ubiquitin-60S ribosomal L40 fusion"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ubiquitin-60S ribosomal protein L40"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_eL40_dom"/>
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        <property type="entry name" value="Ribosomal_eL40_sf"/>
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        <property type="entry name" value="Ribosomal_zn-bd"/>
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        <property type="entry name" value="Rrn7_cyclin_C"/>
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        <property type="entry name" value="Rrn7_cyclin_N"/>
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    <dbReference type="InterPro" id="IPR033599">
        <property type="entry name" value="TAF1B/Rrn7"/>
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        <property type="entry name" value="TF_Rrn7_Zf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
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        <property type="entry name" value="Ubiquitin_CS"/>
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        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01020">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Rrn7_cyclin_C"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Rrn7_cyclin_N"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11781">
        <property type="entry name" value="Zn_ribbon_RRN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
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    <dbReference type="SMART" id="SM01377">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ubiquitin-like"/>
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        <property type="entry name" value="Zn-binding ribosomal proteins"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="24 25 26" id="KW-0002">3D-structure</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9 24 25" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="12 22" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="13" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="11 24 25" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="21">
        <location>
            <begin position="593"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="128"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="551"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="binding site" evidence="24 25 26">
        <location>
            <position position="688"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24 25 26">
        <location>
            <position position="691"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24 25 26">
        <location>
            <position position="702"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24 25 26">
        <location>
            <position position="707"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00035124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00045962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EGS21138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="24">
        <source>
            <dbReference type="PDB" id="7OLC"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="25">
        <source>
            <dbReference type="PDB" id="7OLD"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="26">
        <source>
            <dbReference type="PDB" id="7Z3N"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="27">
        <source>
            <dbReference type="PDB" id="7Z3O"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="28">
        <source>
            <dbReference type="PDB" id="8OO0"/>
        </source>
    </evidence>
    <sequence length="720" mass="83178" checksum="5F9ACF25A706C6F4" modified="2011-10-19" version="1">MAPREYRRFPHSETCAECPARRWYLENGRRYCENGHEVEGYIQYDVDEEDNFGKQGSIARKAKERRTTERKHLTGQPARELYLECLQFLLRKQLLWLVRKKGFHPELEAVCRDLWVLRVREFPGLVGKRDEGKKGRRRSRGTGSESEGTAQGTSGSELEMFSTQSSGGSETEGEGVATGREEGDGVKGRKRRSWKKEVWPLPGVMDTLAIVYLGCVLRGEPVRVGDVWRWARNNQIPFLMAANYLPKSWRDRLPGWAHHALLTRYVRFEGGELHRAVMNLMLGYKENHGLVFPEISTSPMLFLHIRDLALPPEVHPFAQKICRLLNLRFSFPTRQPPPTKYRFLDIPDVLLIAALVVATKHLYPMDGIKRYPRDANDPICRQMDWKVWEEEFSKQSSKKTPILEYERLDPQEIWTMDKEQINELLNWFQETQIDSHKPDDTEIERFFPLAEVPGIPEVPEASQEEIEARLVRIQSAMKTVQPVPDPGDGTGRHIKRIGSDYRRYRSEEELEGHVKKFYEVAAEVSGLSVRDLVRAVYTLEEMLKVWQTEEKRRLKREEEGSDEDRSDSNPHQILRLPANSPVILTSKSGDNRSRIFVKTLTGKTITLEVESSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGIIEPSLKALASKFNCDKMICRKCYARLPPRATNCRKRKCGHSNQLRPKKKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8I4</accession>
    <name>G0S8I4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Mitochondrial fission 1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0030000</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the FIS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693454.1">
        <property type="nucleotide sequence ID" value="XM_006693391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8I4"/>
    <dbReference type="STRING" id="759272.G0S8I4"/>
    <dbReference type="GeneID" id="18257038"/>
    <dbReference type="KEGG" id="cthr:CTHT_0030000"/>
    <dbReference type="eggNOG" id="KOG3364">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104368_2_0_1"/>
    <dbReference type="OMA" id="QFNYAWG"/>
    <dbReference type="OrthoDB" id="421154at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12212">
        <property type="entry name" value="Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000179">
        <property type="entry name" value="Mitochondrial fission 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016543">
        <property type="entry name" value="Fis1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033745">
        <property type="entry name" value="Fis1_cytosol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028061">
        <property type="entry name" value="Fis1_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028058">
        <property type="entry name" value="Fis1_TPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247:SF0">
        <property type="entry name" value="MITOCHONDRIAL FISSION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 11 TPR REPEAT PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14853">
        <property type="entry name" value="Fis1_TPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14852">
        <property type="entry name" value="Fis1_TPR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008835">
        <property type="entry name" value="TPR_repeat_11_Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR008835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS21158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="153" mass="17126" checksum="F336E32F9AACAA59" modified="2011-10-19" version="1">MTQLPYAIDAETPLAPAELAVLRAQYEKEGEMVGVQTKFNYAWGLVKSNQRSDQHLGVMLLSEIFRSSPERRRECLYYLALGNYKLGNYGEARRYNDLLLEKEPGNLQAINLRTLIDDKVSKEGMVGMAIVGGVTVVVGIAASLMFRGFGRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8I7</accession>
    <name>G0S8I7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endodeoxyribonuclease-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0030030</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693457.1">
        <property type="nucleotide sequence ID" value="XM_006693394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8I7"/>
    <dbReference type="GeneID" id="18257041"/>
    <dbReference type="KEGG" id="cthr:CTHT_0030030"/>
    <dbReference type="eggNOG" id="KOG3020">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031506_3_0_1"/>
    <dbReference type="OMA" id="VPCFGWH"/>
    <dbReference type="OrthoDB" id="413993at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053044">
        <property type="entry name" value="Metallo-hydrolase/TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47345">
        <property type="entry name" value="CUT9-INTERACTING PROTEIN SCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47345:SF1">
        <property type="entry name" value="CUT9-INTERACTING PROTEIN SCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="444" mass="48851" checksum="2544D9F85C786EB1" modified="2011-10-19" version="1">MCPPTDSSPPSPPGNSNTPFPWHIGLFDAHCHATDTMSSIPLIHSMRARGLTIMATRSQDQALVAEVAAEHGVSNREALSAETEGKGKGKGKVVPAFGWHPWFSYQLYDDSLPEWASSAGPLTGEMKEKHYGSVLQPEPDKKFITALPDPIPLSQFISQTRGFVQYLQAAGKPVLIGEVGLDKAFRIPWPWGFHPPSQGQGSPSPNNEDDGKGEEGTMTPGGREGRMLSPYHVRMGHQQAVLRAQLRLAGELGVPVSVHGVQVHGVLHDVLAGLWKGFEKEVVSRRKMKMVAPGAEDYFSSSEDEDYDYSDDDGALGRKVKPKLEKNPKSYVPKPFPPRICLHSYSSSPQMLTQYIHPAVPAEVYFSFSTAINLSTAGGASKFPEVVRACPDDRILVESDLHVAGEEMDRALEDICRRVCEVKGWELEDGVRRLRGNWERFVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8L5</accession>
    <name>G0S8L5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Putative transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0038510</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694271.1">
        <property type="nucleotide sequence ID" value="XM_006694208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8L5"/>
    <dbReference type="GeneID" id="18257889"/>
    <dbReference type="KEGG" id="cthr:CTHT_0038510"/>
    <dbReference type="eggNOG" id="KOG0062">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_263823_0_0_1"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000180">
        <property type="entry name" value="MFS monosaccharide transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF61">
        <property type="entry name" value="HIGH AFFINITY GLUCOSE TRANSPORTER RGT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="406"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="442"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="29"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="566"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1004"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="927"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1210"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="717"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1211"/>
            <end position="1225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS21975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1272" mass="139633" checksum="1024475882DB327C" modified="2011-10-19" version="1">MVGAVLFPIEGTADLRRVEAPVSFGAYLLCAFAAFGGIFFGYDTGWMSGVLGMPYFITMYTGMQYDYEAGKPIGVDPTKFGLPSSTKSLMTSILSCGTFLGSLVAGDVADYIGRRPTIISGCFVFCIGCSMQIASTNQTALFVMGRLIAGLGVGFISAVIILYMAEVAPRKVRGALVAGYQFCITVGILLANCVVYSTQARNDPGSYRIPIGVQFIWAVILGIGLFLLPESPRYHVMKGMIKEAAKDLSRVRGQPVDSNYIKDELAEIVANHEYEMQVIPQMSYIGSWLACFQGGFRRRGGNLRRTLIGCGSQLFQQITGINFIFYFGVTFFQQLGTISDPFFMSLVTTLVNVVSTTISFWAVEKIGRRPLLIYGGTGMVISQLVVAVIGVTAGRPEEHNDAAVKTMIAFICIFIFFFASTWGPVGWILVGELFPLPIRSRGVGISTASNWLFNMIIALVAPYMVGNDEHSADLGPKVFFIWGACCVGSTLFAYFCVPEMKGLTLEQIDQMMEETSARESTSESVATILVSCKQTRFDIKCPNYRELDVEGLNITVTSRPVDNGEAKGRGKAKASEGTEILSNAKLRLKAGGRYALVGRNGTGKSTLMRAIAEKLIPGIPEETRISILQQTSVKDVNADDLPETSGPSDGPSVLEEVIDKATSKTELEKEINALSTGLNSPFPHDAVFALRKLRLDRMKKRLFVLDKDARLRSGTRGLQARKALVEYEKQVAAAEAQLSQPPKEISSETLQAETQEAADLLGELQAQVEPSRMAEVEGNAKKILMGLGFKEGDMAKSAGSLSGGWRMRAALATALLKEADILILDEPTNFLDLFGILWLQKWLQHMEDTLATPPTLVFVSHDRDFASSVCTDLIILKDKELTYFHGDLPSYEAAQAEKRIYLTKMKEAQDKQRAHMQESIRQNLIQGRKNDDQNKIRQAKSRQKRLEDRMGMQVNEKGGRFKLNRDLVGWHTSSRAEIVVPQEERGVTIVLPDPTELRFPGSLISLEKVSFRYAGEKGQKVRPPATLIDVSLTVGMGDRIGILGLNGAGKSTLIRLLVGDPAPAGAKVTGNVTTHPRLKLAYYSQHAVEALQRLGQSDPSLTALSLLTSEVSPDAGLDESDIRGLLSSLGLRGNLVSSVPIRRLSGGQLVRLELARLLWRRPLCLVLDEVTTHLDYETVTGLRKALREWEGAVVLVSHDRWFMRGVVEGERDNEDGEEEQDEEEEEGRKDGEGVGRRRVVYKLAGGKLSLLEGGVREFEEGMERRVGRLIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8S6</accession>
    <name>G0S8S6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0040180</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988042">
        <property type="protein sequence ID" value="EGS20279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694428.1">
        <property type="nucleotide sequence ID" value="XM_006694365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8S6"/>
    <dbReference type="STRING" id="759272.G0S8S6"/>
    <dbReference type="GeneID" id="18258056"/>
    <dbReference type="KEGG" id="cthr:CTHT_0040180"/>
    <dbReference type="eggNOG" id="ENOG502S1A6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_1_0_1"/>
    <dbReference type="OMA" id="NIFPVMA"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07730">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF5">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="5">
        <location>
            <begin position="49"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS20279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="393" mass="43725" checksum="5DC28A71D24643FB" modified="2011-10-19" version="1">MAAPPDLGIPPSPHTVDVSIIDTGATIRGAPVRLFLTPPIEGHDYLAAPIYSFLIQHRTLDRTLVFDLGIRKDWKNLSPPLISLLNALGWTLRTKKDVREILDAGGIDTKRIEAVIWSHTHFDHTGDPSRFEPSTALIIGGKLPKGYPADPTSPILETDYTGRELIELDFATGNNGRYKPLQIGRFRALDYFADGSFYLIETPGHTAGHISALARVTPDPDPSFIFLAGDLFHHPGEIRPSRYLPIPSDIRPDPFAPDPHPVDCHYGCPGAIFDELQAQRGRSSVDTFYEPARMTGAESIHEDVDELLRTVNKLQDADAHKNVLVAAAHDESLAEVVEFFPKGKLNDFAQRGSVSRLRWRFLRDFAKAVGKMTHLLGPRREWGPVKGERDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8W2</accession>
    <name>G0S8W2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative chaperone binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0043630</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694758.1">
        <property type="nucleotide sequence ID" value="XM_006694695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8W2"/>
    <dbReference type="STRING" id="759272.G0S8W2"/>
    <dbReference type="GeneID" id="18258401"/>
    <dbReference type="KEGG" id="cthr:CTHT_0043630"/>
    <dbReference type="eggNOG" id="KOG0806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2936">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_419185_0_0_1"/>
    <dbReference type="OrthoDB" id="567237at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07197">
        <property type="entry name" value="nitrilase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08892">
        <property type="entry name" value="SRPBCC_Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.20">
        <property type="entry name" value="Activator of Hsp90 ATPase Aha1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036338">
        <property type="entry name" value="Aha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015310">
        <property type="entry name" value="AHSA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050345">
        <property type="entry name" value="Aliph_Amidase/BUP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="ASHA1/2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674:SF16">
        <property type="entry name" value="CARBON-NITROGEN FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G02350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674">
        <property type="entry name" value="NITRILASE C965.09-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09229">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01000">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103111">
        <property type="entry name" value="Activator of Hsp90 ATPase, Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="3">
        <location>
            <begin position="324"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS19873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="654" mass="73230" checksum="01891863FB531DA2" modified="2011-10-19" version="1">MVLHNPNNWHWVNKDAGAWTKKWLEENLTKLEAKEGDVTAKISRVINMDGDVEVAQRKGKVITIYDFKLTLEFSGSTPEDDDITGTITVPEVTHDLTEDEFVFDIDVYAENKEKQAVKDLVRSKIVPQLRAEFMKLSPALVAEHGKDIQHAPGENPSSGFATPKYHPPTGINAAKAATDVAPKTQANKTGTLVNTTSLSIDPEEFRTTAEEVYLTFTDPQRVAAFTRAPPKVWEGAKVGGKFALFDGNVEGEFLELEENKKIVQSWRLRQWPAGHYSKLQLEFDQNDIDRVTVMRVEWTGIPIGEEDATKRNWLEYYIRSIKATFGSLIQFRPMDLFLDNNFAIASSYIRRAAAEGAHLAVLPEYHLTGWCPERREFLSACSRSSLYLPRYQALARGLRINIVPGTFCEVHRHDPMPISEMPGGTEIRNMAYWIAAGTGELIGSYQKVNLWHPERKVLAAPEPPDGDPSRKVHKAFDTPLIWAAGDGTETKPIRAGMLICWDTIFPEAFRALAAEGAELVVVPSFWLTDPKDESFEGVDTVKINPDCEKVLLSNVVVTRAFKNECVVVFCNAGGVSQVAVPVVGRAPAEKIVKGSQEMTPAREGWIAGTKTEEMAIVEVDFQAVKVLKGEYKTLEDMEKRGWKYYGGPWMKRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9A1</accession>
    <name>G0S9A1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">[acyl-carrier-protein] S-malonyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0045090</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>holo-[ACP] + malonyl-CoA = malonyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.1.39" evidence="1"/>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694897.1">
        <property type="nucleotide sequence ID" value="XM_006694834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9A1"/>
    <dbReference type="STRING" id="759272.G0S9A1"/>
    <dbReference type="GeneID" id="18258547"/>
    <dbReference type="KEGG" id="cthr:CTHT_0045090"/>
    <dbReference type="eggNOG" id="KOG2926">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030558_5_0_1"/>
    <dbReference type="OMA" id="AANYNCP"/>
    <dbReference type="OrthoDB" id="541883at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.250">
        <property type="entry name" value="Malonyl-CoA ACP transacylase, ACP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050858">
        <property type="entry name" value="Mal-CoA-ACP_Trans/PKS_FabD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42681">
        <property type="entry name" value="MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42681:SF1">
        <property type="entry name" value="MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="6">
        <location>
            <begin position="59"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="20"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS20012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="431" mass="47568" checksum="C501342B3EE248B8" modified="2011-10-19" version="1">MLRGAARLLVAASRPRCSRFSLSQRQPLQPISSRHVSSTPSPEPTTPPSKPPRPKTALFFPGQGVEKVSMLTPWLDAFPRTAKPLIDEIDSILGYKLSAIIQDGPPRKLSLTPHAQPAIMATSILILRVLEQEFGFDTEKRVDYTLGHSLGEFAALVAGGYLSFEDGLWMTQRRADAMAAATQAAIQQYGGEYGMVAVVTEPDYLPGLISAIDEFVGNGRSISTLAAQDDDADVHPPPIDQVLIANINSKNQIVLSGSIERIKTLVAHVRQFLGHDPRAVRLKSEDPFHSPIMRPAVEVMRDILAHEKSRASGRQNSEIVVWPGKIPCVSNVTARPFESREELKDLLARQCLETVRWWDSIRYLDQECRVRRWVGIGPGKVGRNLVGKEVGMRGKDVVKGGGVWAITDPSEIEECLRGLEETEHLVDEPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9K1</accession>
    <name>G0S9K1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">General negative regulator of transcription subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0046170</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694997.1">
        <property type="nucleotide sequence ID" value="XM_006694934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9K1"/>
    <dbReference type="STRING" id="759272.G0S9K1"/>
    <dbReference type="GeneID" id="18258655"/>
    <dbReference type="KEGG" id="cthr:CTHT_0046170"/>
    <dbReference type="eggNOG" id="KOG2150">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013819_3_0_1"/>
    <dbReference type="OMA" id="YKPQTPY"/>
    <dbReference type="OrthoDB" id="293823at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1020:FF:000006">
        <property type="entry name" value="CCR4-NOT transcription complex, subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012270">
        <property type="entry name" value="CCR4-NOT_su3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007207">
        <property type="entry name" value="Not_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04065">
        <property type="entry name" value="Not3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005290">
        <property type="entry name" value="NOT_su_3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-Not complex component Not N-terminal" evidence="13">
        <location>
            <begin position="3"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="14">
        <location>
            <begin position="497"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="237"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="359"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="480"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="21"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="381"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="413"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="434"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="483"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS20112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="694" mass="77677" checksum="343A27353DBD74A1" modified="2011-10-19" version="1">MAARKLQQEVDKCFKKVAEGVSEFEAIYEKIEQSTNQAQKEKLEDQLKREIKKLQRLRDQIKTWAASNDIKDKAPLLEQRRLIETQMEKFKAVEKAMKTKAYSKEGLSAAAKLDPKEQAKIEASEFLSNMVDELEQQIETLEAESESLQATMKKGKGHAAKAERVAEIERIIDRHKWHQGKLELIRRSLENGGVDAEQVNDLEESIKYYVSDGMNGDFMEDEGMYDDLSLQDEEDAYGMNQDNDKTSSQDNQSIQSSKEKKEEEQEAEQPEKPSKPAPALSGKQRAAVEAATNAGRRPSNQLKSPLPTLATVHTTSSSNLSNGTSGPQMKPAAVPSRLAGEGLKYASAAAAAAANEKNNVGIAPLPPPPANAPGGPGPQGRISTTNSPRVPSSQPAGQDKASTAGSSSTVTPAKAGARSKAAAQPPAQAEAESSKATAQTNGASNVKPSQEAEEEEPIYHLPPSLQDLVDSYEISKKRAAALSSPSTQRMQAVSNASKPSALDGEPPRSYQPEVRFYSHTRYPQEPLPIFDDPRLYSRIDSDTLFYVFYYKQGTYQQYLAARALKDQSWRFHKQYQTWFQRHEEPKQITEEFEKGTYRFFDYESTWMNRRKADFEFHYKYLEDELVHLNTGQSVMALRYRRLSSKIPPVNWEDPPGYMDLAMLGITSSRNDETSREFDAVWYRNEAMWDKSDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9K4</accession>
    <name>G0S9K4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative GAMM1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0046200</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MYG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695000.1">
        <property type="nucleotide sequence ID" value="XM_006694937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9K4"/>
    <dbReference type="STRING" id="759272.G0S9K4"/>
    <dbReference type="GeneID" id="18258658"/>
    <dbReference type="KEGG" id="cthr:CTHT_0046200"/>
    <dbReference type="eggNOG" id="KOG2948">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051576_0_0_1"/>
    <dbReference type="OMA" id="FHCDEVV"/>
    <dbReference type="OrthoDB" id="10265310at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003226">
        <property type="entry name" value="MYG1_exonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215">
        <property type="entry name" value="METAL DEPENDENT HYDROLASE - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215:SF1">
        <property type="entry name" value="MYG1 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03690">
        <property type="entry name" value="MYG1_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="361" mass="40935" checksum="2BD8D1BFC6AE1404" modified="2011-10-19" version="1">MAETAAKRLKTDVTVGTHNGHFHADEALAVYMLRQHVPQYIGARLVRSRDPAVLNECSIVVDVGGEYDPARNRFDHHQRSFATTFPGRQTRLSSAGLVYLHFGRGIIARKLGQPEESEPVGLVWNKLYESFIEALDAHDNGINVYDPERLKSAGLEKRFSDGSFTLGAMVGRLNPNWNDPIPEDPVEAQAQEDSRFEQASQRIGEEFDRSLEYYTLSWLPARDLVADAFKARYEWDSEGRIMVFKGQSPPWKDHLYALEEQDPDANQVYYVLYPEKPVEGSKWRVQCVPVTKDSFESRKPLPEHWRGFRDEELDRTSGVSGCVFVHASGFIGGNKTFEGALAMAKRALELERLEELSMDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9N1</accession>
    <name>G0S9N1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peptide hydrolase</fullName>
            <ecNumber evidence="14">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CTHT_0046490</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Extracellular aminopeptidase that allows assimilation of proteinaceous substrates.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the peptidase M28 family. M28E subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="14"/>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695027.1">
        <property type="nucleotide sequence ID" value="XM_006694964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9N1"/>
    <dbReference type="GeneID" id="18258687"/>
    <dbReference type="KEGG" id="cthr:CTHT_0046490"/>
    <dbReference type="eggNOG" id="KOG2195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025866_0_0_1"/>
    <dbReference type="OMA" id="FTHSWNQ"/>
    <dbReference type="OrthoDB" id="2214at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF56">
        <property type="entry name" value="AMINOPEPTIDASE YDR415C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="8 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005130814" description="Peptide hydrolase" evidence="14">
        <location>
            <begin position="20"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="15">
        <location>
            <begin position="173"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGS20142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="374" mass="40709" checksum="6B2137091E5B61C4" modified="2011-10-19" version="1">MRSQALFALLATWAWSTAAAPAAEQAPRPSRPGLRLIKTSPEDHGKWVTEEQKIEFRTKGINFIDITDITDEEVLTALSSPNLEPADSFSAQAVTYPSRVSHQTEANALIAQASTTNPKNWLQTLTNYHNRHYRSTYGTQAGTWLYNTVKNIASVNPAITVTQFTHSFNQPSIIVQIPGNSTNLVIVGAHYDSTAGSSSARSPGADDNGSGVVTILEALRVLANAKFKGKNTIEFHFYAGEEAGLLGSAAIFSNYKSNRKTVLAMLNQDMTGYSPNGKLAVYTDYVDSSLTSYVRVIANAYIGSVNTDRCGYGCSDHASARSNGFPAAYVCEDTMDDASPYIHTANDAYSTIMWDAVLRHIKFTLAFLVEASYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAD9</accession>
    <name>G0SAD9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0041930</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694596.1">
        <property type="nucleotide sequence ID" value="XM_006694533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAD9"/>
    <dbReference type="GeneID" id="18258231"/>
    <dbReference type="KEGG" id="cthr:CTHT_0041930"/>
    <dbReference type="HOGENOM" id="CLU_816367_0_0_1"/>
    <dbReference type="OrthoDB" id="440424at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="340" mass="37532" checksum="3FD7548AA97BE73F" modified="2011-10-19" version="1">MNTLRSLLSCLPMKGKKQDFYTELIYDTTDGEKIAIYLEDDAIPYTDEDIPLYRDEDTAEKEKTPSTSGKEDALMPYTDGDILFSHGHIDKDLIADPVPLHVENASLFPSSPAMPFPNPAHAILPSLPNQHLFPSPFTFSTKLPNLKEIPSPEDQQVALRFVTLLVTLPSTHPTPAQLTAVLFHTVDAIGQGRENLGPAMREALDEIVPVADEVFNFPRNHPESLGGFLMIVGVGVLGEMIGGWAVGKLGFVFENLNDVEGEGEIGDGFVGEMGMGEMGEQYMGTDSARMRARVVYGEDSPQVKIKEGTVAEWWMREYAAYIPPGSVEEYLRLLDLQDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAG8</accession>
    <name>G0SAG8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0042230</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694625.1">
        <property type="nucleotide sequence ID" value="XM_006694562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAG8"/>
    <dbReference type="GeneID" id="18258261"/>
    <dbReference type="KEGG" id="cthr:CTHT_0042230"/>
    <dbReference type="eggNOG" id="KOG0591">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_500669_0_0_1"/>
    <dbReference type="OMA" id="NCEEQML"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF98">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="76"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="430"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="500"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="430"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="462"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS19740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="554" mass="62189" checksum="4239D6FFEE069306" modified="2011-10-19" version="1">MPTSSVSSQSSGMQLIPLSDYLQKADDTNFVWDEDSREQSDEWLDPIREAGLDYRKHKVFAAHTGHKRPKPPKPFTRSGPELGDSGSTVVYRVTAPAGVDYGRPLALKVISLRDGSRPMGATSQARLRALGEVATLAALRHPHIVRYVASYEEFSVQPWLLPHWSPRPKSHSAKQLAKAAAPEPDDDVNSGRSTRIGRHVLGIAMYPPGQCNLRTLMEEVAVAPDTSGWIMACMHNYFGCLSQAVAYLHRNSVRIRHKDIKPENIVIDKWGVPILTDFGLSKHFERGQYSQGPTFKTLKYADPEAIKERPRDERSDIFSLGCVFLEIATVLLGQHPEYAEQQLSNGTKESYDFHYSEHLHNLDSYLEKLSNQVAPDLIASDPSREASAKAIVAVLPYIRQMMDVSQWRRPKAKELYPWFRHLYDIHEHPGPCRTCEEERRTGRAIPLPNGDDDDDNNSRRSCSSPERTGPPSSAPVSRTATSLCLANLGRHNTQISLASTCPSSQPAPRVPFETYEPPSTPPIWKTEFQDEMIVEWSEPLEDEGGDTDMDLWDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAM4</accession>
    <name>G0SAM4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0042800</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694681.1">
        <property type="nucleotide sequence ID" value="XM_006694618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAM4"/>
    <dbReference type="STRING" id="759272.G0SAM4"/>
    <dbReference type="GeneID" id="18258318"/>
    <dbReference type="KEGG" id="cthr:CTHT_0042800"/>
    <dbReference type="eggNOG" id="ENOG502S3EX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019274_0_0_1"/>
    <dbReference type="OMA" id="EYGMQKQ"/>
    <dbReference type="OrthoDB" id="5400327at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057678">
        <property type="entry name" value="DUF7918"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223:SF5">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25534">
        <property type="entry name" value="DUF7918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7918" evidence="2">
        <location>
            <begin position="234"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="581"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS19796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="606" mass="64697" checksum="DBD356BB8DE9F87E" modified="2011-10-19" version="1">MPCFKGIAVSIHANGAPLPEYGIQKQSRFSRINTYIPVPQPQVNPETGKPEPAKFAISITLLTPGLAIPYSTPKPTPSNPFPKPQLVGPMPSSTGDRGKYHGVVTPYIPLTNNENETIAAYIYFDGRAKEEVATLLRPGEETWVNSRWVQVPESEGGGLAEREFLFREVGLERWLNGLDLKGHDAAEKLEKRRQKFERRRRRQQALAEAAAARSLDGSAPRSTLRYSIDEGAPLEAVPDEDSVSSSDDDEPPEAAGQIKVAMYRVIASGEVKKGEYSPQFDAHDDSDSDEKDPPNGLDADVEHTTSFAKPKTLDPKTISTQTVTGIDGPDKPYAVFTFFYRGERQLQKMGIIPPPKQATSPALKRRSGQLDFSNLGPLKTTGTVGFTAFRDKESQARRKKARKNNGAPGIPSSAMDADSDDDDDDEHIGDSEDLSKMDDVDAKYDPSKLGPEDAKHTGELAEGVNRIRLKRAHSAEPDSSESPRKSPGASDSVTPTDSNAPGGIASAAQGLFGRNQLPGENDNSIIGSPLKKARPSLGAEGLSASIAGATATGVAASSSAASTTGNPFLPSALGDVLAKAQAGAGQAGADQKGAEASVKMEEEEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAN8</accession>
    <name>G0SAN8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribonuclease H2 subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ribonuclease HI subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0042940</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694695.1">
        <property type="nucleotide sequence ID" value="XM_006694632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAN8"/>
    <dbReference type="STRING" id="759272.G0SAN8"/>
    <dbReference type="GeneID" id="18258332"/>
    <dbReference type="KEGG" id="cthr:CTHT_0042940"/>
    <dbReference type="eggNOG" id="ENOG502SCDS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057573_0_0_1"/>
    <dbReference type="OMA" id="YYFCPKL"/>
    <dbReference type="OrthoDB" id="29098at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09270">
        <property type="entry name" value="RNase_H2-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040456">
        <property type="entry name" value="RNase_H2_suB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019024">
        <property type="entry name" value="RNase_H2_suB_wHTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041195">
        <property type="entry name" value="Rnh202_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383:SF11">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09468">
        <property type="entry name" value="RNase_H2-Ydr279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17745">
        <property type="entry name" value="Ydr279_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rnh202 triple barrel" evidence="8">
        <location>
            <begin position="53"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Ribonuclease H2 subunit B wHTH" evidence="7">
        <location>
            <begin position="160"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="98"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="343"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS19810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="414" mass="45548" checksum="8094969435557EE6" modified="2011-10-19" version="1">MARTRSKAASFDPKDKAKDQDSQTKDSSSPQTSSSKSIYSLPEPSDRPSQVFILPKSATSSARIITLANPRTGSPTRYLVCPKTGFFEITKVTPPKSAPRSWLVQRSAHSESQEDGEQEGAATTTAQTISSPTLYLATPFDPVFLLLPALIAEPESAGTTNHLLDLLDLHHPSLREILSSRLAAVCDVVQAGDEDMYRLSEEKLVGEMLVKARRMISGNGLPASLEERWVKKALEAPVVGVRVVKRGDSGSQVSTNGESQGTTPDEEEPALRPAIVASPEVVHLQRLRTALDFLSSRYLPPTLSALLKFHLTSQSPLSKKFNIDFTPLDEYLAQLTKVRQEAAASRATTDFSRKRLGGGGNDDDEEADEKAEKRRKKEQEERIKKQNVSRGVRELAKVNTKGMMKLSEFFKKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAR3</accession>
    <name>G0SAR3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Lactoylglutathione lyase</fullName>
            <ecNumber evidence="3 9">4.4.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glyoxalase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0043200</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(R)-S-lactoylglutathione = methylglyoxal + glutathione</text>
            <dbReference type="Rhea" id="RHEA:19069"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="ChEBI" id="CHEBI:57474"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="4.4.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glyoxalase I family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.5" evidence="3 9"/>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694720.1">
        <property type="nucleotide sequence ID" value="XM_006694657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAR3"/>
    <dbReference type="STRING" id="759272.G0SAR3"/>
    <dbReference type="GeneID" id="18258358"/>
    <dbReference type="KEGG" id="cthr:CTHT_0043200"/>
    <dbReference type="eggNOG" id="KOG2944">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_0_1_1"/>
    <dbReference type="OMA" id="MGDAWGH"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="UniPathway" id="UPA00619">
        <property type="reaction ID" value="UER00675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07233">
        <property type="entry name" value="GlxI_Zn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004361">
        <property type="entry name" value="Glyoxalase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00068">
        <property type="entry name" value="glyox_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374:SF30">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE GLYOXALASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00935">
        <property type="entry name" value="GLYOXALASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="VOC" evidence="10">
        <location>
            <begin position="11"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="10">
        <location>
            <begin position="170"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS19835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="325" mass="37170" checksum="4FF938A45FEB7805" modified="2011-10-19" version="1">MATATDVKNYKFNHSMIRVKDPNESIKFYSFLGMSVLNKLSFPEAKFDLYFLGFDSPKAVSHGNNVWDREGLIELTHNYGTESDPNYKVNNGNVEPFRGFGHTCVSVDNIQAACKRLEDAGYKFQKKLTDGRMKDIAFVLDPDGYWVEIIGQNPVEKTEGVTETDVQTYRMNHTMIRVKDIEKSLKFYQEVLGMKLFRTIEQPEAKFNLYFLGYPGEKGIPESVDAIKEREGLLELTYNYGTEQDPDFSYHNGNAEPQGFGHICISVDNLEAACARLESLNVNWKKRLTDGRMKNVAFVLDPDGYWVEIVQNERFSGKPNFPHTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAR5</accession>
    <name>G0SAR5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0043220</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694722.1">
        <property type="nucleotide sequence ID" value="XM_006694659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAR5"/>
    <dbReference type="GeneID" id="18258360"/>
    <dbReference type="KEGG" id="cthr:CTHT_0043220"/>
    <dbReference type="HOGENOM" id="CLU_2512430_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="85" mass="9140" checksum="0D6CCBF03BFBBE0F" modified="2011-10-19" version="1">MDLSDSDENSYIDNDTDSDTASASSLSSGSDFDTDIDSETDSDSCSDSSSDSDSSDDVALTPFPPPRRRQLPSYNDQPTYPSMPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBF3</accession>
    <name>G0SBF3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0050070</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695355.1">
        <property type="nucleotide sequence ID" value="XM_006695292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBF3"/>
    <dbReference type="GeneID" id="18259045"/>
    <dbReference type="KEGG" id="cthr:CTHT_0050070"/>
    <dbReference type="HOGENOM" id="CLU_1602497_0_0_1"/>
    <dbReference type="OrthoDB" id="5403747at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="166" mass="17749" checksum="6A5C10C9500F1C7F" modified="2011-10-19" version="1">MVPKAQSIEPKENKGKKYPILDIFTDRETAIILCTVANAALMPEANFEHVAKQMDMKNPRSIANAWGEIKKKIRDYQTKLPEDLRMPTPAPVDAEGPAAPAGRARSAICRLHGSGRVQKPEGASGAGDKRGRPHKAVAVSATAAAQKLVTPMPSAEDEEAGGEGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBF9</accession>
    <name>G0SBF9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative cellulose binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0050130</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695361.1">
        <property type="nucleotide sequence ID" value="XM_006695298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBF9"/>
    <dbReference type="ESTHER" id="chatd-g0sbf9">
        <property type="family name" value="Acetylxylan_esterase"/>
    </dbReference>
    <dbReference type="GeneID" id="18259051"/>
    <dbReference type="KEGG" id="cthr:CTHT_0050130"/>
    <dbReference type="eggNOG" id="ENOG502QUMZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040058_4_1_1"/>
    <dbReference type="OMA" id="CPNTREV"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630:SF13">
        <property type="entry name" value="ACETYLXYLAN ESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="CUTINASE RV1984C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409027" evidence="7">
        <location>
            <begin position="30"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="8">
        <location>
            <begin position="274"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="244"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS19539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="310" mass="31849" checksum="05987DA77C9D4557" modified="2011-10-19" version="1">MWPSPKVAALLLWAHSLLVAGSPVDTTEASELVARQSCPEIHVFGARETTVPSGYGTAGQVVNLILQAFPGATSEAINYPACGGQASCGGIQYGDSARQGTQAVANAVNSFHQRCPNTKLVLVGYSQGGQIMDNAVCGGPDTGSGITTTTPPISQSALDAIKAVILMGSPRYVAGLPYNVGTCTAQGFAARPRGYVCGSNSSDKIQNYCDSTDPYCCTGNDANSHQQYGVKYGQQALNFVRSKLNSSSGGGGGSPTTSAGGSQPTQPSNGGGSNCSPKWGQCGGQGWTGPTCCQSGSTCRFQNNWYSQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBR2</accession>
    <name>G0SBR2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0054480</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695783.1">
        <property type="nucleotide sequence ID" value="XM_006695720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBR2"/>
    <dbReference type="GeneID" id="18259486"/>
    <dbReference type="KEGG" id="cthr:CTHT_0054480"/>
    <dbReference type="eggNOG" id="ENOG502T2GE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049751_1_0_1"/>
    <dbReference type="OrthoDB" id="5377226at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="337" mass="36398" checksum="7174C640C62D3411" modified="2011-10-19" version="1">MPSVTQDPPTAPSPSCKKRKLDDTAQLYAALVANFPSAKADHPVLEFYRAANCSNTGLLADGSLDHATLSPQHHLVSPLAGRKISPASPWGKRQRTSPDSSGPAEGDLMQRSPSNSPTQRYQRPSPPLRSSAKTAGLGDKTRSATVASQTTTPTPTISQSLMSRCHICSRKPTKKSELDSFTDCQGCGRRTCYICIRECLGWGPPAAMMNHAQADSRAPPTPTLPQEPSFTMVDIDLLDDDGNTNDIGADSYHQRIVEQQQLALLKSQQQAQQQPQMQLQQSVGNQCREGEVKAGRGFDGWPNSGGGHRQRVCSRCCVERGEDGEVVCLGCLPFVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBV8</accession>
    <name>G0SBV8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0054960</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695829.1">
        <property type="nucleotide sequence ID" value="XM_006695766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBV8"/>
    <dbReference type="STRING" id="759272.G0SBV8"/>
    <dbReference type="GeneID" id="18259534"/>
    <dbReference type="KEGG" id="cthr:CTHT_0054960"/>
    <dbReference type="eggNOG" id="KOG1065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000631_11_0_1"/>
    <dbReference type="OMA" id="PYVINHD"/>
    <dbReference type="OrthoDB" id="5839090at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000138">
        <property type="entry name" value="Putative alpha-glucosidase AgdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF133">
        <property type="entry name" value="P-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="7">
        <location>
            <begin position="412"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="8">
        <location>
            <begin position="837"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="622"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="622"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS18884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1063" mass="119055" checksum="D3AA314AF552F614" modified="2011-10-19" version="1">MRVLTPSLSAVGTEPAGNILNSSVLKPVGRSLSHTILQSYADRVSSSSSFSRLPCSLVTTKAIRLMKPLIVLIIGIRVVFAEAAREASIEAEVKPTIWANIHKSNPVSSVKEKFLSGWRRKIFQLDDIESLNSLAFEVDTGQNVLPNIKDPEAINPQAICPGYKAADVRYTQDGSFTASLHLAGKPCNLYGNDIEHLILEVEFQASDRLHIEIKPRYIGQENETWFLLPDVLVPRPRPESWSEQGPSDFEVEWSNEPTFSLTVKRRETGDILFSTEGTVLVYEDQFVEFVSSLPENYNLYGLGTLYAADVADNIDANIYGTHPIYLDTRYFEVNEEGYMTYTPYAAATDRTTSYVSYTHGVFLRNAHAQEVLLTSEGITWRTLGGSIDLYFFSGPTADAVIQSYQRTAIGFPAAQQYWTLGFHQCRWGYENWTVVQEVVENFSRFEIPLEAIWTDIDYMNKYRDFENDPQRYSYEEGAEFLDRLHSNGQHYIPIIDSAIYVPNPENPEDAYPTYDRGVKASAFLLNPDGSIYYGAVWPGYTDWVGAVLNGTGTIDWWIEELSIWSEKVAVASFCVGSCGTGNLTLNPVHPPFVLPGEPGNPILEYPEGFELTNSSEAASASAAKHSRTAAAKPTSTTKTSSYLRTTPTLGVRNVNWPPYTINNFHGDLAVHAVSPNATHHGGYLQYDFHNLFGHQILNATYQALLKIKPGKRPFIIGRSTFPGSGKWAGHWGGDNESRWALMYFSIPQALSFSIFGIPMFGVDTCGFGGNADAELCSRWMQLSAFFPFYRNHNILGARSQEPYVWSSVAEASRRAMRIRYMLLPYLYTLMMQASLDGSTVMRALAWEFPNEPWLADADRQFMLGSAVMVTPCLEQGATTVKGVFPGVRDGKTVWYDWYTGRKASEGVRPGENITIDAPLGHIPVFLRGGSVVPVQEPGMTTTESRSKPWGLIVALDWHEFAEGVLYLDDGESLMPQEVTWVKFSASTGSLIVQPAGTYVDINPLANVTVLGVKNKPHKMWLDGQDVEPGYWRYREEKETLELRGLEALFMEGAWKKTWELRWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBW3</accession>
    <name>G0SBW3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription initiation factor tfiid-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0055010</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695834.1">
        <property type="nucleotide sequence ID" value="XM_006695771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBW3"/>
    <dbReference type="STRING" id="759272.G0SBW3"/>
    <dbReference type="GeneID" id="18259539"/>
    <dbReference type="KEGG" id="cthr:CTHT_0055010"/>
    <dbReference type="eggNOG" id="KOG0008">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000572_1_1_1"/>
    <dbReference type="OMA" id="RFINYYR"/>
    <dbReference type="OrthoDB" id="5752at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040240">
        <property type="entry name" value="TAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022591">
        <property type="entry name" value="TAF1_HAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12157">
        <property type="entry name" value="DUF3591"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 1 histone acetyltransferase" evidence="4">
        <location>
            <begin position="435"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="65"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="893"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="921"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1017"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1080"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="897"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="931"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1021"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1051"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1086"/>
            <end position="1104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS18889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1114" mass="125999" checksum="9D98F827DC01299D" modified="2011-10-19" version="1">MDDDGEIDYSTLNDDDWKEQEARDDEIIKNINEHLATSAASELLSRIEAGEAFDQTGKAEDAIDFEDIDLSEDELPDEEPPSRAKPAAEDTADAADENPPEEEEEDLFGDRPTSRDSNRDIVASPRSISGDGEGEESADEHQAPRESLAELMALNFNLDPPNLASNQDPNIPPPAENLLEAVKQVYPGFEENAILSWNQLLRPKQAEWISKKPAKPPKPLVPTKLSLELDVDQEKLFRIPGPAQVPIRQKIRDAEARGLICLEEPEPIEQADLEVFNIDDDEDSETVGGFTLRDIALVCDDWDSMIRLGDRLPSPQPAPIPEPRLDDNILIKNEVDPDDEDWDRMFLSTNSRVIPQKRRAPPKGLPPIPRFTAPNFDNFEEATAKLGKRVILDMNDPYLLLEDVDSERQAKRRKVQHKMVRMANGRLGRDLTQRFNFSNDAAYEALKENSQSKVRATLYSINIEHSMTAQRLTYPFYRVKLAASDPHSYHRPQFHPKKEAFLPVRFKPPAVKRKKLLKGKRIPEIFQTSADLSMNDNSTAILFEYCEEIPIVLSNHGMGQKIINYYRRSKGTDSRPEKRELGEPYILMPEDRSPFAMVGQVQPGETVPTLHNQMFRAPIFKHTPRNTDFILGRSTTGKNGSTWYIRNIDHLFVVGQTLPSMEVPGPHSRRVTNIAKNRLKMVSYRLLRRSDNVTLSDITKHVADSNESQNRQKLKEFLVFQKDKRNWVLPEGEELMPESEIRSLVRPEDVCLLDAMQVGAHELENGGYEINDAMFKDDEAFDNIGDDLPADALANKMAPWRLTKAFIDASHGKAMIAVHGPGDPTGKGLGVSYIRTSMKGGFLEQLHGPLATSADAIERQRKANGGHMYNVKNQDTLYTESLRDIWERQRKSLEDTTEHDDNDVLAQEDEDDRFNVQSQVPAQSTNLPDGVSQVSQSQASTQNRKKLKIIREIKDENGQTRIVTEIVHDPVVIAQYLKRRRQMEFENIDVYNAKLTGDPEKDELILEKARIEQERLEKNKERRKKREKQKKLQQKMREGGDISILDEDSPEPSTEKVTGTTRKCANCGQVGHIKTNKKLCPLLNGSRPQNQNPDDAASLGSTNAPVAASFISLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBY8</accession>
    <name>G0SBY8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative heat shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0055270</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">Part of a larger complex that includes HSP70, HSP90, and immunophilins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695859.1">
        <property type="nucleotide sequence ID" value="XM_006695796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBY8"/>
    <dbReference type="STRING" id="759272.G0SBY8"/>
    <dbReference type="GeneID" id="18259565"/>
    <dbReference type="KEGG" id="cthr:CTHT_0055270"/>
    <dbReference type="eggNOG" id="KOG0548">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000134_46_5_1"/>
    <dbReference type="OMA" id="MYSAREN"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000004">
        <property type="entry name" value="Putative stress-induced-phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000010">
        <property type="entry name" value="Stress-induced phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000020">
        <property type="entry name" value="Stress-induced phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000002">
        <property type="entry name" value="Stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000027">
        <property type="entry name" value="stress-induced-phosphoprotein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041243">
        <property type="entry name" value="STI1/HOP_DP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17830">
        <property type="entry name" value="STI1-HOP_DP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0346">Stress response</keyword>
    <keyword evidence="4 6" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="4"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="STI1" evidence="8">
        <location>
            <begin position="141"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="331"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="STI1" evidence="8">
        <location>
            <begin position="531"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="200"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="223"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00064323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS18914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="583" mass="65253" checksum="CEE7CECAE73CAD67" modified="2011-10-19" version="1">MSTAEELKALGNKAIAAKNFDEAIDKFTQAIALDPNNHILYSNRSAAYASKKDWEKALSDAIKTTELKPDWPKGWGRKGAALFGKGDLLGAHDAYEQGLKLDPNNAGMKNDLEAVKRAMEKEAGGAGGFDPNASIGKLFSDPNLIQKLASNPKTSALLADPSFMAKLQSIRQNPNNMQELFSDPRLIQVLGVLMGVDMEMRSPDEAGGPSTTKAQEDVPMPDAPKKEPEPSKKEPEPEPEEELDDEEREKRQKKAEADKEKQLGNENYKKRNFDEAIKHYEAAWDLYKDITYLNNLGAAYFEKGDYQACIDTCTKAVEEGRQMFADFKLIAKSYARIGTAYEKMGDLTKAIEFYNQSLREHRTPEVVNKLRTAEKNKIEAARKAYIDPVKAEEAREEGNKKFKESDWPGAVAAYSEMIKRAPDDPRGYSNRAAAFIKLLEFPSALEDCDMAIKKDPKFIRAYIRKAQAYFGMREYSKCVDACADALKVDAEHYNGANTKEIEAQQQKAFSAMYAARENETEEQTRERLMRDPDIMSIMADPVMQSILQQAQADPAALAEHMKNPMVRTKIQKLIAAGVIRVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBZ3</accession>
    <name>G0SBZ3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dipeptidyl-peptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0055320</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695864.1">
        <property type="nucleotide sequence ID" value="XM_006695801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBZ3"/>
    <dbReference type="STRING" id="759272.G0SBZ3"/>
    <dbReference type="GeneID" id="18259570"/>
    <dbReference type="KEGG" id="cthr:CTHT_0055320"/>
    <dbReference type="eggNOG" id="ENOG502QZDY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015590_2_1_1"/>
    <dbReference type="OMA" id="FWTKHGY"/>
    <dbReference type="OrthoDB" id="416441at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050585">
        <property type="entry name" value="Xaa-Pro_dipeptidyl-ppase/CocE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00976">
        <property type="entry name" value="CocE_NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056:SF10">
        <property type="entry name" value="COCE_NOND FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xaa-Pro dipeptidyl-peptidase C-terminal" evidence="3">
        <location>
            <begin position="317"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="600"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS18919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="622" mass="71501" checksum="D2C6A9C6447F3E95" modified="2011-10-19" version="1">MPNHIRLDLHTIDDTSFPYVFEQNVTVHLKSGDLVRCNVYRPKTADRVPVLVTYGPYGKDIHYKDFSPKFAEVNPRHKSAHSAWETPDPGYWTAHGYAIVRADEVGTGQSPGVLDTMSPSTTDAFAQVIEWAAEQPWSSGKIGLLGVSYYAGSQWRVAARRPKGLACIIPWEGMSDYYRDRCRHGGIYSNGFIKWWWDRQVITNQYGRPGRAAANWGPDTLEGDLPESELLENRRDQVVENRKYRYRDDEYHACREYNLADIEVPLLSVGNWGGILLHLRGNIEGFTHAGSKLKYLRMITGRHDLPFYYDDEVEIQRSFLDAFLKGEDRVGWSQPGKVPPINLVIRKGNVGVNNPDGEATYPRREEYEWPLARTQYTKFYLHPDRTMRREKPRGPEPLALTYHALLTPDDWDEVLHFITPPFEEETEITGHIIARLCVSVSADRAKMRPPKQPTDIDLFLTLRHIGPDGCEIYYTGTAGDPVPLTKGWLRVSLRKVNEEHPWHRPWLPYREYRKVDQEMLEARTVYTVDVEIWPTCVVVEKGSQLLLEVSSGDTQGCGIFTHDDEYDRDPEVFQGWNHIHFGPDYQNYVVLPIIPPREEAAQGNRCDSRDKEVGSDETEKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0SC02</accession>
    <name>G0SC02_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">N-acetyltransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0055410</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695873.1">
        <property type="nucleotide sequence ID" value="XM_006695810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SC02"/>
    <dbReference type="GeneID" id="18259579"/>
    <dbReference type="KEGG" id="cthr:CTHT_0055410"/>
    <dbReference type="eggNOG" id="ENOG502SQRM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060131_6_5_1"/>
    <dbReference type="OMA" id="LMYPNGV"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF17">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY FAMILY (AFU_ORTHOLOGUE AFUA_8G05690)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS18928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="253" mass="28247" checksum="F218AECB0498FC97" modified="2011-10-19" version="1">MTTNPRIRVRDATPADAPIITEIHYKAFAHGIMDQLMYPNGVTEDNRAKFAARLFPPPRSEDEKAKKGENMVWVAEYVPDDGPAEIVAFSRWTLYRQPRPEEVWKVDAAYKPTLEMFGQGANIEVIDTFVGEMRRMSERAAKGEAMLFLGILACLPERQRLGAGSALLRRGVELADSLGLPMRLEASPEGYGLYKKFGFEAYDVLDTKVTETWGPVQPEGSNWGNNNAAELFGQAPKGVLRTVLMKRPVKVSN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2014-10-29" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G0SC29</accession>
    <name>NLE1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome assembly protein 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Notchless protein homolog 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Ribosome biogenesis factor RSA4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0055700</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2014" name="J. Cell Biol." volume="207" first="481" last="498">
            <title>A network of assembly factors is involved in remodeling rRNA elements during preribosome maturation.</title>
            <authorList>
                <person name="Bassler J."/>
                <person name="Paternoga H."/>
                <person name="Holdermann I."/>
                <person name="Thoms M."/>
                <person name="Granneman S."/>
                <person name="Barrio-Garcia C."/>
                <person name="Nyarko A."/>
                <person name="Lee W."/>
                <person name="Stier G."/>
                <person name="Clark S.A."/>
                <person name="Schraivogel D."/>
                <person name="Kallas M."/>
                <person name="Beckmann R."/>
                <person name="Tollervey D."/>
                <person name="Barbar E."/>
                <person name="Sinning I."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="25404745"/>
            <dbReference type="DOI" id="10.1083/jcb.201408111"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 33-517</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2015" name="J. Cell Biol." volume="210" first="169" last="170">
            <authorList>
                <person name="Bassler J."/>
                <person name="Paternoga H."/>
                <person name="Holdermann I."/>
                <person name="Thoms M."/>
                <person name="Granneman S."/>
                <person name="Barrio-Garcia C."/>
                <person name="Nyarko A."/>
                <person name="Lee W."/>
                <person name="Stier G."/>
                <person name="Clark S.A."/>
                <person name="Schraivogel D."/>
                <person name="Kallas M."/>
                <person name="Beckmann R."/>
                <person name="Tollervey D."/>
                <person name="Barbar E."/>
                <person name="Sinning I."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="26150393"/>
            <dbReference type="DOI" id="10.1083/jcb.20140811106112015c"/>
        </citation>
        <scope>ERRATUM OF PUBMED:25404745</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in ribosome biogenesis. Required for processing and efficient intra-nuclear transport of pre-60S ribosomal subunits. Interacts with the AAA-ATPase Midasin, which is essential for the ATP-dependent dissociation of a group of nonribosomal factors from the pre-60S particle.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associates with the pre-60S ribosomal particle. Interacts (via WD repeats) with uL18. Interacts (via UBL domain) with MDN1 (via VWFA/MIDAS domain). Interacts (via WD repeats) with NSA2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NLE1/RSA4 family.</text>
    </comment>
    <comment type="sequence caution" evidence="5">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EGS18955" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18955.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695900.1">
        <property type="nucleotide sequence ID" value="XM_006695837.1"/>
    </dbReference>
    <dbReference type="PDB" id="4WJS">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.80 A"/>
        <property type="chains" value="A=33-517"/>
    </dbReference>
    <dbReference type="PDB" id="6QTA">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.89 A"/>
        <property type="chains" value="B=30-128"/>
    </dbReference>
    <dbReference type="PDB" id="8PV1">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.56 A"/>
        <property type="chains" value="Ch=1-517"/>
    </dbReference>
    <dbReference type="PDB" id="8PV2">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.63 A"/>
        <property type="chains" value="Ch=1-116, Ch=118-517"/>
    </dbReference>
    <dbReference type="PDB" id="8PV3">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="Ch=1-517"/>
    </dbReference>
    <dbReference type="PDB" id="8PV4">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="Ch=1-517"/>
    </dbReference>
    <dbReference type="PDB" id="8PV5">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.86 A"/>
        <property type="chains" value="Ch=1-517"/>
    </dbReference>
    <dbReference type="PDB" id="8PV6">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.94 A"/>
        <property type="chains" value="Ch=1-517"/>
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    <sequence length="517" mass="57549" checksum="AC226E54F6B35E68" modified="2014-10-29" version="2">MATLAPPPSKRQRREEIQRTQTQQDVTPLVATDLGSFKANFIDSDGNQMTDVVEINFADATEKNISNLLNTLLGRDREEFTPYRFRIHIPGKDLIIDQYPNDLLSLLQKHGVTNPFETTITLSAEPQAIFKVHAVSRLAHRIPGHGQPILSCQFSPVSSSRLATGSGDNTARIWDTDSGTPKFTLKGHTGWVLGVSWSPDGKYLATCSMDTTVRVWDPESGKQVNQEFRGHAKWVLALAWQPYHLWRDGTARLASASKDCTVRIWLVNTGRTEHVLSGHKGSVSCVKWGGTDLIYTGSHDRSVRVWDAVKGTLVHNFTAHGHWVNHIALSSDHVLRTAYHDHTKEVPGTEEERRAKAKERFEKAAKIKGKVAERLVSASDDFTMYLWDPTNNGSKPVARLLGHQNKVNHVQFSPDGTLIASAGWDNSTKLWNARDGKFIKNLRGHVAPVYQCAWSADSRLVVTGSKDCTLKVWNVRTGKLAMDLPGHEDEVYAVDWAADGELVASGGKDKAVRTWRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
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        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
    <sequence length="247" mass="27656" checksum="A971A049F300FD8A" modified="2011-10-19" version="1">MAKSIINKHRKRGVQLRSAPRKFKPTLRTKTHNSITRPKSPQQLAKEKDHKSVTSKRDPNNNSSSNSNNKDKNVTPEQIREKARVSHNLAERQYRAKLNSNFEVLLDALQECGYLIEDIPITIDGEDSAMDDSAAGGPDPEDHRGYHRDNGDKVVAAAARHVGRPECGRGDAVQDSRGRSGSQQQQPRRISKADVLNFAAQVLCLQKHKLEEKEKEVQEKDERLSRLLVSLRSIGIKPADSLMLGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCD3</accession>
    <name>G0SCD3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative sequence-specific DNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0056810</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696004.1">
        <property type="nucleotide sequence ID" value="XM_006695941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCD3"/>
    <dbReference type="STRING" id="759272.G0SCD3"/>
    <dbReference type="GeneID" id="18259719"/>
    <dbReference type="KEGG" id="cthr:CTHT_0056810"/>
    <dbReference type="eggNOG" id="ENOG502SDP0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033452_0_0_1"/>
    <dbReference type="OMA" id="VAWERRS"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051775">
        <property type="entry name" value="Homeobox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24323">
        <property type="entry name" value="CEH-10 HOMEODOMAIN-CONTAINING HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24323:SF7">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="92"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="94"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="169"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="293"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="557"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="602"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="23"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="293"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="319"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="342"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="375"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="557"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="618"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="652"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS19059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="703" mass="75307" checksum="41DE611E4585AA31" modified="2011-10-19" version="1">MDKEGPQQLRDQPQPQGPAPDVSSSQEQQQQSPTQATETQTQQSSSSSPNSSSQNQTSISPPATKSLPATTATTPMATPEPAARPKSAQELFHPKNKRKRTNSHDKEILEAAYRANPKPDKAARLEIVKKVSLNEKEVQIWFQNRRQNDRRKSRPLTTDEFIVITDATQVQPDATGLYYPSPAGPAPSSSYSAPPTVAQTPAPAHMQPPSQAPMRTPMSAPERVRQPPLSSSSAGDSSAVKETPEPDSVAWERRSMIGFDSATPSHAPPGTTRSAPATLTRTFSGDVGYLANRWNTGSAVTTPRTPFTSDTRPLPPPTSSSSQPLRLSLSLDGKAELVSNLPSPPRPTPTPPLAPPPIPRAGLQRSYSTSAVCCTPSTPITLPPLSSITSSLPPPSSSKSTPTAKPPLPPRLTRGRSLDVSAWEFCCDSESKGEDALSVQAKLESQNARDAMVEINLVRSTGGAGAYLGRRRGSLGGGQGVKRPRASLGTNGKVGVLGVKGGSVLNQQQRQLIGARAGEKVDLTGAKPPAGIQSYRIYDGDDSDKENWSPEKAECLSLRKESPPHGFREHADPAGKGYDALYDSTQVAYRSCGRVRLNDRLIRSPPTKRSPPSVEVYRDDDDDSDIDEEDERSCEESNCQGDEAEGRDGSCCRSSPTNSQASGRSSALLDEEVERFMQSVSPSKKSDADAVAGLLSLSQGNWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCF7</accession>
    <name>G0SCF7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative DNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0057050</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the COX17 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TEL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696028.1">
        <property type="nucleotide sequence ID" value="XM_006695965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCF7"/>
    <dbReference type="SMR" id="G0SCF7"/>
    <dbReference type="STRING" id="759272.G0SCF7"/>
    <dbReference type="GeneID" id="18259743"/>
    <dbReference type="KEGG" id="cthr:CTHT_0057050"/>
    <dbReference type="eggNOG" id="KOG3496">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4346">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005799_0_0_1"/>
    <dbReference type="OMA" id="AGIMVKL"/>
    <dbReference type="OrthoDB" id="10258062at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1130:FF:000004">
        <property type="entry name" value="Cytochrome c oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.720:FF:000004">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.720">
        <property type="entry name" value="Telomere length regulation protein 2, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007745">
        <property type="entry name" value="Cyt_c_oxidase_Cu-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038528">
        <property type="entry name" value="TEL2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051970">
        <property type="entry name" value="TEL2_Regulation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019337">
        <property type="entry name" value="Telomere_length_regulation_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830:SF10">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05051">
        <property type="entry name" value="COX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10193">
        <property type="entry name" value="Telomere_reg-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5 9" id="KW-0186">Copper</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telomere length regulation protein conserved" evidence="11">
        <location>
            <begin position="607"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="527"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="999"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="540"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="569"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="999"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1014"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="1038"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="1039"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR607745-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS19083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1082" mass="117856" checksum="D1B7DABFCC869940" modified="2011-10-19" version="1">MEELLKPASIIRKPKPDPELELVATSVIQHHSNSNIETSSTTTTNPKLGPPTSPEDALSALKSQPDYDTLMTILRFLSHHKPQNSSFPTIKLPSPLTAQLVQVLVSDVVPNYWTLLLESVHDAKNSGLKLLLYCLSSVTGVNAILVRLRALIQDAKADGGDKGKKIEISMTLGILVDLLNRLLHGDGWLSEAWQVATSREDGPARVRPRVQEILTAFGSGRMVSLAAEAEAIVKGNGTGKDVEGSWVADSLQYIQWLGRNIVAFLESEAAAKDTKFASDVFGKGLRLGHADALTKQLLSSLVLQKGADPKKFGMLLDGLPQTEQRKVLFSVLKFFSSDYLNRLGRCEGDNSKALVSAVAGALSFIVNGMSSGRKHLVEWLTSSSAAGVGEEVGIRRAVLAVVAQEKEDICTVVEKSINQFGDQLYIKHSPMLQQEAHAQVLLISAGYVHRKVAVKLAMLLRSGVWMNTISNRLKASNLRARFIGMIVGEALSALVDKEDKRLNFHMEETDQEEGQWYKGLTKVMDDTGPLDPLSQPLSQTTPKKPFKTSKPAQKPTAPISGSKPLIIEELSDEGEDDDIIPYAKPDSDPEDSDDDPTLIRRDKPKAPVYIRDLIKYLRDTDSYDRQKLALETAPTLIRRKAGYGTELSEHAEELGSLLVGLHDRYDLENFNELRAQGMIALIIAKPEMMGPWFARTFFEGDYSINQRASVLVVLGLAARELAGLETSDYASAAAFPSKKLPEKVEQLYLTQPSTTAAAKLPSPSSLKPLPPNALDTIATSLTNDFLAPLAARAADAATGPDILKLSTFTSRLRDKAKQKTTSRPRVRSIPNTTASLLSHYFFSPLVARFQAALHSAPARGSSIRGQRASLLWHPQLLALYLQTLALVVHAAGPSTLSLPAMTADLWRLLLSTRVRACAVGDLAVTRAVLFGFMALLDVNEERMRDVCGELGREVVEAQEWVAGVFDGLRGGDEGGEEEEVKMLAAGVLVRLREGIERWQSNSSRNNMGNSQSTPAAAPAPVAAAPAANSQAENKPKPCCVCKEEKAKRDDCMLFSTASDPQKDCQSTIEAYRACMAGYGFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCJ1</accession>
    <name>G0SCJ1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Uracil-DNA glycosylase</fullName>
            <shortName evidence="7">UDG</shortName>
            <ecNumber evidence="7">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">UNG1</name>
        <name evidence="11" type="ORF">CTHT_0057420</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="7"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696062.1">
        <property type="nucleotide sequence ID" value="XM_006695999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCJ1"/>
    <dbReference type="STRING" id="759272.G0SCJ1"/>
    <dbReference type="GeneID" id="18259780"/>
    <dbReference type="KEGG" id="cthr:CTHT_0057420"/>
    <dbReference type="eggNOG" id="KOG2994">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032162_2_0_1"/>
    <dbReference type="OMA" id="PDNGYLM"/>
    <dbReference type="OrthoDB" id="10031947at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097510">
        <property type="term" value="P:base-excision repair, AP site formation via deaminated base removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.470.10:FF:000007">
        <property type="entry name" value="Uracil-DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003588">
        <property type="entry name" value="PRK05254.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003589">
        <property type="entry name" value="PRK05254.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003592">
        <property type="entry name" value="PRK05254.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264:SF0">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00987">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="10">
        <location>
            <begin position="126"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="312"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS19117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="390" mass="44183" checksum="B645602723853846" modified="2011-10-19" version="1">MSTLKRKAAAEAGSEPKKIKQAGIMSFFGTASKSSDSNSNNNNNNSTNDSEPAPKFDKAKWVASLTPEQRKLLQLEIDTLHESWLALLKDELVTKEFLELKRFLERETAAGKQWFPPKEDVYSWSRYTPFNNVKVVILGQDPYHNYNQAHGLAFSVKPPTPAPPSLKNMYIALKNDYPLFREPPNRGGLLTPWAQRGVLMLNTCLTVRAHEPNSHSNRGWERFTQRVIDLVAQRRTRGVVFMAWGTPASKRVMKIDTKRHLVLKAVHPSPLSAARGFFTCHHFKLANDWLEERYGKEKGPIDWALIEGDSVFEDKQPPLGSPAAKKREEEEQQQRTPKKGSLTEKVEEVVKASVLGRNVKETIASVMEEKKREVEEKEKGEENVAPKAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCT1</accession>
    <name>G0SCT1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1479 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0058320</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696152.1">
        <property type="nucleotide sequence ID" value="XM_006696089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCT1"/>
    <dbReference type="SMR" id="G0SCT1"/>
    <dbReference type="STRING" id="759272.G0SCT1"/>
    <dbReference type="GeneID" id="18259870"/>
    <dbReference type="KEGG" id="cthr:CTHT_0058320"/>
    <dbReference type="eggNOG" id="ENOG502QR55">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011148_0_0_1"/>
    <dbReference type="OMA" id="MFQGWVA"/>
    <dbReference type="OrthoDB" id="8249012at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010856">
        <property type="entry name" value="Gig2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613:SF1">
        <property type="entry name" value="DUF1479 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G09280)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBIU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07350">
        <property type="entry name" value="Gig2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS19207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="495" mass="55121" checksum="113672F999208598" modified="2011-10-19" version="1">MAISGGPLQIPSLMFDSLSLAKRDEMMTSSSSGPIHLTHRFSVLKESLTKGKETVLTSSWNRLLHELSREIDLVSALGTLAIPIINFADIENPQYSEQFLGQLRLRGVGVIRGVIPQRTASTWWQETQEYIGQSRHPKPQDVYWSPAQVKARACPNILAAQRFVMSIWKSRDPTARVTTSFPITYADRMSVRRPNHDQAHIGAHVDGGSVERWEPDGYGRAGTYNEIFQGRWEQYDPWESSTRLGVTSDLYHRTGACSIFRMFQGWLALKPIPSGRGSVHVCPLPRHATAYFLLRPFFSPRDGTSNNPNTEWSITSPQNSILHGALPSYAQEIHPSLHPHLQLDRSLVPVPALEPGDYLIWHPDLIHAISSPPTSSSSSEQLYPMYMYLPACPLTQTNALYLARQRKAFLRGHPGPDFFEAGAGLSSFGGRREPGGEADHAGHPGVRDVNDAGGDDGLRAMGLLPWDEEEALTDHEREVLAMANGILFPDLYDMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCX8</accession>
    <name>G0SCX8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0058740</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696194.1">
        <property type="nucleotide sequence ID" value="XM_006696131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCX8"/>
    <dbReference type="STRING" id="759272.G0SCX8"/>
    <dbReference type="GeneID" id="18259912"/>
    <dbReference type="KEGG" id="cthr:CTHT_0058740"/>
    <dbReference type="eggNOG" id="ENOG502S91F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_434738_0_0_1"/>
    <dbReference type="OMA" id="DMWDSIQ"/>
    <dbReference type="OrthoDB" id="5421421at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="647" mass="71655" checksum="B1BF9D04808EA278" modified="2011-10-19" version="1">MMDTDRQDNLGSPLIEDFLDCEKLIADLEGDTTSSSSPSTLSTPPTRTLKRLHIDISMTSTQYLAPGVNHSDRMGVDGMPVCSSGPAAVSYSTSEMSPYSAVSAVSSFNYPAAADPSLLTPVSSASSPPLSQRPPKNPRTYHSQTLSPPVSQVPTPPNTSKLYYGYEGPSNGGSSSPMTVNPAATEGGHFDVNPYANHHPSTPKSEVPPLVDPYLGSFAVSGGNDNDVHHPMPDYPYHVDVVPNGVFLGQQPLPHPIQHQRMPSDGQAPAIPQTHPPQFRPHSAPQAGTIEDLRASQFLGAYPSQAEVSPGRKTQPRKKPAASKKASRTAKSTPRNGSPGQSPDSNQDEPEEELELDPEAPEEEKYLFQLRKEYLSERGKGMWEEMKARYSERFQGNFEKACLQMKVSRAVARYGIWPKKEEQRLREAFEYVESIRYQLIISRMKENGGCRVWDWKPQHIEAKLIKMGLEEKTLDEKTGFRRRKKLTRRQASPPHSGMHPSVVGDWRNGLGLHHTYPHHLVAHPQQLHARPFEHMVPPEDSTNVIASFTSDVETIDDSILDQIYGRRNSHGIKEERDFTPESMDMPCTNANYDQQAKPNGLASTAALTEQQRCSERIARQAACEQLMQQLSRNATPYGVPTAQAVQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0SE26</accession>
    <name>G0SE26_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutaminase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0062180</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696534.1">
        <property type="nucleotide sequence ID" value="XM_006696471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SE26"/>
    <dbReference type="STRING" id="759272.G0SE26"/>
    <dbReference type="GeneID" id="18260256"/>
    <dbReference type="KEGG" id="cthr:CTHT_0062180"/>
    <dbReference type="eggNOG" id="ENOG502QPQS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008020_1_0_1"/>
    <dbReference type="OMA" id="WTGYLVR"/>
    <dbReference type="OrthoDB" id="431715at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052743">
        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032514">
        <property type="entry name" value="GtaA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033433">
        <property type="entry name" value="GtaA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF12">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17168">
        <property type="entry name" value="DUF5127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16335">
        <property type="entry name" value="GtaA_6_Hairpin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaminase A N-terminal" evidence="2">
        <location>
            <begin position="110"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="1">
        <location>
            <begin position="354"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="1">
        <location>
            <begin position="522"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="1">
        <location>
            <begin position="678"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS18203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="823" mass="92475" checksum="B9584AA646B8F1B5" modified="2011-10-19" version="1">MKLDVLALAAVAGASTLTPNVLPLIVRNPYLSTWLYHARGAPWDNWPIFWTGAHVGFSVMASVPETGKVYPLLGRPQDSLRWDHPQYKITYPEYLGANFDASTTNLTYRIYGFSSSNSALVTLSFLSPITPSSTFRQSIPAAYMTIYVEGCIDLNIYTDTNGEWVTGNRNNQIKWTLHTPVRYGNGQGTALKSWKVSRVHEQLFTEFADHAEWGTLYFSAPSDVHHQAGTSAILRQQFAEHGALSNTVDKRWRKVMQEEPVFAFSKSFNLAGKKKVDRWPPKADSITFTFALIQDPVVQFASAKGLIHMKPLWQSYIHTTDELITYHYDDFPTAAALAQNYSDTLAIDAFNSGSSEYKDIAALSARQVLGATQFSGTPDRPILFLKEISSNGNFQTVDVIFPSFPFFLYTNPKWLAHLLEPLLEHQLSGQYPNDYSMHDLGAHFPNATGHPDGKDEYMPVEECGNMLIMALALANALKDEDSSSPAYLQAHETAAEVLPYSPSGASADKYGFDLVGKTSGEEAATRWLARSWKLWEQWTGYLVRESLIPHNQLCTDDFAGWLANQTNLALKGIIGIRAMSEISEMLGKVDEAKHYRAIAEWYIDKWQEYGISRDGTHAKLAYTWESEGKGSDYDDAKDQVPGRLRGQKPLGGLSSLARRASLVRKRSEATQYKKREVFIPDRIYQMQSDWYSAVLQRYGLPLDSRHLYTKSDWEFFAAAVTSKKTRTEILTAVARWVNETSTDLYDTEGTGGYPGIHFMARPVVGGHFAFLALEGACGGKAIEALRFLDEIEPKELDVVRLLRRERELGLELQQKEGWRGEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEL1</accession>
    <name>G0SEL1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0064130</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696719.1">
        <property type="nucleotide sequence ID" value="XM_006696656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEL1"/>
    <dbReference type="STRING" id="759272.G0SEL1"/>
    <dbReference type="GeneID" id="18260451"/>
    <dbReference type="KEGG" id="cthr:CTHT_0064130"/>
    <dbReference type="eggNOG" id="KOG0274">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_103_3_1"/>
    <dbReference type="OMA" id="TMCRAAQ"/>
    <dbReference type="OrthoDB" id="190105at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22147">
        <property type="entry name" value="F-box_SpPof1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF1">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="6">
        <location>
            <begin position="452"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="701"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="818"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="858"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="900"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="940"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="269"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS18388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1044" mass="116859" checksum="93DC03859A81F4CC" modified="2011-10-19" version="1">MEARRSRSSHKVSMTIEEDEATVTHRMMQFADECIETKTVTTTTTTKRSYPPIFLREPRDVRSLDSKEYPLASKPTPPELQRLTFEIDDFQTVGWDEDEEEDDILDSQVSTAGGIIGFVHSPAHTTAQLQARRSQSTDYVRDIKVEPGIESPMAAASQTPVPPPELLQPRRSRRSIIRAVSPIHTPMLTRSSRLAAAKPALIAYAQPDKLRRAATRGSRREAEKAIRRPSGLFTTPDNSELAISRSTNMRPFPTDSFDTGVSQSTAVYDAASPTGDDSQAAFSNVATPPITDTDLRPFEATDDPLSIGRSPASRRSINAVAAQDVSLPSPRLSPTLAAAQLQSHADDDADDYETSFSTQLVRSRQNWADETQITEDSHDGAGPMDLSPVHYENSISRSRSGRPRYVDPATMLNTFDAMPDKLKTWMMFQFLRRCSRNTLHVVADVVNPALKTDFLKQLPLELSWHVLSYLDHRDLCRAAQVSKHWRRIVDGNERGWKELFDRDGFVLAPGELERAIKEGWGWQDPYGPYEYERDLTKPDRMTASESELMQSVVKSEKIEPAPKTRAAKRKRALTSLNERAAKRRAGVDGKVDGKNSQTAKMLKFEGPISAANAAALAVPDPGIGLPSLRQLHLFKSLYRRHYLIRRSWMSGDAKPRHIALAAHPRHVITCLQFDDDKIITGSDDTLIHVYDTKTGQLRKRLEGHEGGVWALQYEGNTLVSAGTDRSVRVWDIQKGQCTHTFYGHTSTVRCLQILMPSDTGKVDADGKPIMMPPKPLIITGSRDSQLRIWRLPEPGSRRYIQTGPPPNDEQCPYFIRILSGHNHSVRAIAAHGDTLVSGSYDTTVRVWRISTGELLHTLVGHNQKVYSVVLDHRRNRCISGSMDSTVKIWDLNKGEMLYNLEGHSMLVGLLDLREGRLVSAAADSSLRIWDPETGKCKKVLDAHTGAITCFQHDGSKVISGSEKTVKLWDIETGDCVQDLLTDLNSVWQVKFDWRRCVAAVQRGNLTYLEILDFGAARDGYKPDELGHRILLNQDEVQRLVEEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEL7</accession>
    <name>G0SEL7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0064190</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696725.1">
        <property type="nucleotide sequence ID" value="XM_006696662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEL7"/>
    <dbReference type="GeneID" id="18260457"/>
    <dbReference type="KEGG" id="cthr:CTHT_0064190"/>
    <dbReference type="eggNOG" id="ENOG502QT0U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017280_0_0_1"/>
    <dbReference type="OMA" id="WGEINDD"/>
    <dbReference type="OrthoDB" id="434648at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052032">
        <property type="entry name" value="ATP-dep_AA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041472">
        <property type="entry name" value="BL00235/CARNS1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43585:SF2">
        <property type="entry name" value="ATP-GRASP ENZYME FSQD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43585">
        <property type="entry name" value="FUMIPYRROLE BIOSYNTHESIS PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18130">
        <property type="entry name" value="ATPgrasp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="372"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS18394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="752" mass="83213" checksum="37A4D1FF1BF937E1" modified="2011-10-19" version="1">MPHSTAFEQPTAMDKGHTLPNGQPLKRSFEEFQSSKSALTSNNNGRRKKSTVSLCPPILVDVVPLCDLYSVINIVIFPSSNYSTINGTSNQNGLHRVNGSNGINGTDHRASNSEAFSPLAAALTAISLGPANWSPSSLTVFTAILPLQDGYIYRSDFLQLRLQDCPIPIVKIYENVKPLEKYKAWTLPLTTLRTEEALASAIEQGYVAGVIQWASLEATLSVVDMYDHLKRLVTELRCRLHNAPWLTSKPIPRKRVALIRGRPNLTAGGPIYRTARALGLELVIVDEPGHWLQPDTEENKMYREAFLATDMTEDEGVVDRIVKSLRSYPLPIHGVFTLSDNFFVTVARVAELLGLPCNPSSAFEISVDKYRSRLLQEMPGRIRRVKTMKDCKEYLESPERWQGTLIVKPTKGWSSECVSKVTRVGDLWPAISKAIARHGTDAVIEPFYDGPEIDANFILQDGEILFSEIADEPPFEADSPEASPDSTFSPEALTMPSALPTIEQEIAKSTLRDLLLKAGFHTGVFHVEARIVCSSAVYKDVDGSGVVDLIPKHKAGPARLQVSDSCYKMTPADRLSDTNGDIENPECKLLEINARPPGYRVTVPARHTYGVDYFAAHMLACIGDTDRLRLAACPFAFQDYPEHMALPAAQYHSRIVYIPAPAAGIVRWPVTGVPPCEELKQRRPDLANYIVLGVDYCVPGDKIELQTDGARTYVAHLLVVSRESRRKAIEIGNEVAREYRIIVEGGQQAKQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEM8</accession>
    <name>G0SEM8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Late endosomal/lysosomal adaptor and MAPK and MTOR activator-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0064310</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696736.1">
        <property type="nucleotide sequence ID" value="XM_006696673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEM8"/>
    <dbReference type="GeneID" id="18260469"/>
    <dbReference type="KEGG" id="cthr:CTHT_0064310"/>
    <dbReference type="eggNOG" id="ENOG502SGDI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108580_0_0_1"/>
    <dbReference type="OMA" id="RIVRYQH"/>
    <dbReference type="OrthoDB" id="5299893at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071986">
        <property type="term" value="C:Ragulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001919">
        <property type="term" value="P:regulation of receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028209">
        <property type="entry name" value="LAMTOR1/MEH1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15454">
        <property type="entry name" value="LAMTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01262">
        <property type="entry name" value="LAMTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="4" id="KW-0564">Palmitate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS18405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="17891" checksum="F533D8F97AF2DA7A" modified="2011-10-19" version="1">MGICSSCLGRRRADEYIEDDEAQHLFDDPNTVNYGSFEQQHVMAQEDPQEVQREIEALQRVVARTSDNMVDIYDIIPASNDKATTAVLQPGTFAFHGQDPTAARFQTLLAKLSSHEDLASAARIDWGTPDDDHFEMQQGAPPIKVAGGEPLLGNFADAAAAMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-12-14" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEP4</accession>
    <name>G0SEP4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0064470</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696752.1">
        <property type="nucleotide sequence ID" value="XM_006696689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEP4"/>
    <dbReference type="GeneID" id="18260485"/>
    <dbReference type="KEGG" id="cthr:CTHT_0064470"/>
    <dbReference type="HOGENOM" id="CLU_2277180_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="102" mass="11521" checksum="EFD8E999E99C84FE" modified="2011-10-19" version="1">MRLLTSLPRVTSCLRPFPKQQIRSYPTTGGDAGPEFSKPGRGMAGDLTMGRVTREFNKDGTDPTPRRWALYSMGAVGLGGAYLMMRPRRLPKREVIRQMREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0SF44</accession>
    <name>G0SF44_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAR-17a/AIG1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0060750</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696391.1">
        <property type="nucleotide sequence ID" value="XM_006696328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SF44"/>
    <dbReference type="STRING" id="759272.G0SF44"/>
    <dbReference type="GeneID" id="18260113"/>
    <dbReference type="KEGG" id="cthr:CTHT_0060750"/>
    <dbReference type="eggNOG" id="ENOG502RZDB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062880_0_0_1"/>
    <dbReference type="OMA" id="QHAMNSG"/>
    <dbReference type="OrthoDB" id="419711at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242:SF1">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242">
        <property type="entry name" value="OS02G0130600 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="32458" checksum="B4C7A5B42FCE1B95" modified="2011-10-19" version="1">MARNLFKFGVDPWDPTHRFETSWILSPFALFCCRALLSLYAFATLLTILIYDCIHSPEHCAESRATFSYFTHLTYWGLAFYFLVSAVHTFTYARSGIPLLAKLPRPLQALHSLFYTTVTVFPFIVTIVYWAQLYDGHWYTEVFRGWSNVSQHALNSAMALFEIIVPRTEPPLAIHMLWLIIILALYLCVAYVTYADKGFYTYNFLDPEEQGAMLAAWIVGIAVGCCILFGVVWGLIWMRKKVTEEKLGLKGKFFGGATAMEDASSSVVRELEEGKHEGSVPLENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFC5</accession>
    <name>G0SFC5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CWH43-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0061560</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696472.1">
        <property type="nucleotide sequence ID" value="XM_006696409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFC5"/>
    <dbReference type="STRING" id="759272.G0SFC5"/>
    <dbReference type="GeneID" id="18260194"/>
    <dbReference type="KEGG" id="cthr:CTHT_0061560"/>
    <dbReference type="eggNOG" id="ENOG502RZQS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_953170_0_0_1"/>
    <dbReference type="OrthoDB" id="10032492at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="2">
        <location>
            <begin position="149"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS18141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="292" mass="33279" checksum="D66CDC89026539A5" modified="2011-10-19" version="1">MPPLKPPLLILSRPLLFLLPPLIASTAWFTTLLILLLYWLVHEHSAYYAVSMASAQRIAFISDVAANATPNRRMYPVFITGCLVTALAMSATLALDWWWLHRRGLVRRRALERRLENRIEKEEGERREKGGGKGVNVAAGLVLGFAYHPEQRPFRFSYYTKVFFVVVEVSLAIAFFACVRTRHYQPAAVLEWVIALIFAAWAFSFCLDLYPAARQWEKQRRQQQEEEEGSNHEAGDGAVNAEMENSNELTTHPARLTKQPTSRGYLALKIYDRLEFYFGGGTSLPCRGKRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFS1</accession>
    <name>G0SFS1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0071910</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697454.1">
        <property type="nucleotide sequence ID" value="XM_006697391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFS1"/>
    <dbReference type="GeneID" id="18261229"/>
    <dbReference type="KEGG" id="cthr:CTHT_0071910"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_783037_0_0_1"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF163">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS17836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="38279" checksum="7B24FAEC15000CCB" modified="2011-10-19" version="1">MSISTSSRDEEQPLLRRSSEMNRITERSLQYGVVDFTSSGLTPPTDAIVVDFDPLGDPDNPLDWATSFKWTIVGMLAMMAFTVTFTCMSPVPLASAIVSELSHSPNPASSSSVLLVTIWELGEAAGPLVIAPLSEMVGRYRVINTANVIFITAIALAATATSVEQFIAARMLTRLAVASNVLAPEIVGDIFLRKLGEAILRPMIVLSGSGVLMAMSLLAGTVFTFLYVYNTTLADMLVNVYKIPPEMVGSCYVVFSLGSAISVVICNIALDRIYVRIRNSHSGVGRPEFRLPLAIIGCFLLPLSVGAYGWSTELRLPLAVLLFATTLMGSAILLATIPIMAFDVKIRRFLEEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFT0</accession>
    <name>G0SFT0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0072010</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697463.1">
        <property type="nucleotide sequence ID" value="XM_006697400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFT0"/>
    <dbReference type="STRING" id="759272.G0SFT0"/>
    <dbReference type="GeneID" id="18261239"/>
    <dbReference type="KEGG" id="cthr:CTHT_0072010"/>
    <dbReference type="eggNOG" id="KOG1529">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031618_1_2_1"/>
    <dbReference type="OMA" id="RETITFC"/>
    <dbReference type="OrthoDB" id="566238at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051126">
        <property type="entry name" value="Thiosulfate_sulfurtransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43855">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43855:SF1">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409480" description="Rhodanese domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="64"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="215"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS17845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="332" mass="35944" checksum="A2207349936C8D79" modified="2011-10-19" version="1">MIGHHRLAALLSAAAALLPSASAAAVASPASSELVERTLIPLPCYIFGPTVSPWWLKLCKPHLDLVVIDLRSADEYAANHIPGSFSLPFEPVSAWSNMGPGDLLLEMPPSADIFATLGSIGVSNPNPATKVVLVNGVGNPAFPQAASPRVATTLKYAGISEGRVSVLDGGFPAWLSEGYPVTTAVPTPTPRTYTATEDRSFLVNISYVAERINKKHQHIYIIDGRDEAVYNGTILEEWADKPGHIPSAVNLPAKYVWNPDGSWKSPLELLAQLRSKVGYGVSRSYGEIIVYCGVGGYASTWYFVLTRILGFDNVKMYDGSAQEWSKYYDMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGA3</accession>
    <name>G0SGA3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0065610</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat MORG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696860.1">
        <property type="nucleotide sequence ID" value="XM_006696797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGA3"/>
    <dbReference type="STRING" id="759272.G0SGA3"/>
    <dbReference type="GeneID" id="18260599"/>
    <dbReference type="KEGG" id="cthr:CTHT_0065610"/>
    <dbReference type="eggNOG" id="KOG0316">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_1_1"/>
    <dbReference type="OMA" id="MCWDIRT"/>
    <dbReference type="OrthoDB" id="71437at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051980">
        <property type="entry name" value="WD_repeat_MORG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842:SF3">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING PROTEIN 83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="16"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="83"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS17242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="385" mass="40851" checksum="D5FEBCACCE6CEE5D" modified="2011-10-19" version="1">MAQRAPKFPSRPVAQLVGSNGPVHALTYSASPSTYILSGSSDRSIRLYNPTNATLPPLSSSSYVTKSTSSTPSIPISTPIQTYTSHAYAVLSIAVSRSNAHFVSSGGDRAVLLWDVSTAQTIRRFGASSIAHSHTGRVNAVLFAGDTVENQNDAVAENMVVSAGVDATVRLWDVRSSNPKPIQILTEARDAVTCLAVHGPAILAGSVDGRLRTYDVRMGKCIADTMPAAVTSVCVSRDGRTVLVGTLDSKMRVLDRGEGTCLRTFPGQNGGEDGAWRNEELRVQSVFGGGERWVVVGDEMTGAGEVNFSNGEGRVWAWDLLTGKLVAKVNVPWGAGETGKKAIGRDGREKERKNVVSCIAWKESGFGDQFCVGGTSSVVTVFGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGA7</accession>
    <name>G0SGA7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Factor arrest protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0065650</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696864.1">
        <property type="nucleotide sequence ID" value="XM_006696801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGA7"/>
    <dbReference type="STRING" id="759272.G0SGA7"/>
    <dbReference type="GeneID" id="18260603"/>
    <dbReference type="KEGG" id="cthr:CTHT_0065650"/>
    <dbReference type="eggNOG" id="KOG3680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003184_0_0_1"/>
    <dbReference type="OMA" id="KMTRAMR"/>
    <dbReference type="OrthoDB" id="18234at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040185">
        <property type="entry name" value="Far11/STRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021819">
        <property type="entry name" value="Far11/STRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012486">
        <property type="entry name" value="Far11/STRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239:SF4">
        <property type="entry name" value="AT25231P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239">
        <property type="entry name" value="PROTEIN REQUIRED FOR HYPHAL ANASTOMOSIS HAM-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11882">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07923">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01293">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01292">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Far11/STRP N-terminal" evidence="2">
        <location>
            <begin position="184"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Far11/STRP C-terminal" evidence="3">
        <location>
            <begin position="593"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="846"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="890"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS17246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1105" mass="123469" checksum="BB8B881194BC992B" modified="2011-10-19" version="1">MNTVLPLRPAPDGAAAADAPRGDAESSDQITTTTTTTTTTTTTTTTKTTAATAATPSPGPEAVPIPGQSSPQQLRQPQQRRPSLHRNQQPPAPSPLIPPARIPPLPPFRSSVEIKNNINNAIKLQQQSQPPDQQASQYQRPQPSQQQDGSSPQGQDSLSLAQLRRLVAEVPRNAQGAPMPPAEPIAYDYVYEDIAPLEEEIDEWFVYTFRQLMRLTTANQAFDAAWNRTYPPTAERSGTVRWDGEGEEVEKRKMEFVKELVNGVRGGDKALKSEAVGALMYLVLGRWMESVKGAASPNLADGKARSAATWEQLSAMREGVRLLTECGGIEAVWDALKDAFNILWGPDTPSNIQLHVEELLNLMTIMYVLISEALDSPLEMAFVRDKLLALEPSLVNYMFRATVQLRWDDTGALPHPQVFLLFWKSILLVFGGIHEIAETKKATCEMEVNSEKEVITASPLDYHVFRQEITSKYPAYVPPQPFLPLEADQTSILPRLPNHPIKNDGSNGIIQPPPGPAGSSILHQPVHIATPAPSPPPSPGVGKGGKKQSYQTNQNFPFMYPPLDETSTNTGGKGAAALQDQLVGRKWEGSDVPASILEAGELFHKRVRMTRATRQLWAEREEFLKHERGWEGPDADIIDELDLSSLTLEDREELGLPLTNDQQKKSAVPEVDYGPRPVDEETKRRLDAVEAFYKEALPHLQSLVIVLLKQVMTMANGAPQAQQDQGIAGQRPQGPAQKGLYGIGSTARGEPTSPTDAEIEELRNKEIACKAATGILILLLKWFKLSHVLKFEYLTQLLLDCSYIPMALKIFAVHDVQQMVESRIDRLEHSFFYFCGQRAGVIIQRPTMPNPTATEFEDDSDGEAIPPPIKRRRSPVLAPSALADSDPLSAQALDSTSSSPDPPGRPEVDELGYPVHPLPKEPITDFSRRNLYTLINHLRIVQKICKRKAHRNLLMVQYKSSQILRKILKVPQHELRLYALKLFKSQVPYCGRKWRQSNMRVITAVYLHCRPELRDEWLAGVDLDTELEEALPLEQALRSLTHWFNLRRYPESMLAGGLREEVLREEQDFFMRELEKADLMGWLQREREGQANEEEAGQWEHEGWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGQ9</accession>
    <name>G0SGQ9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0067230</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697016.1">
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        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
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    <sequence length="822" mass="87439" checksum="F28A02EA772092E8" modified="2011-10-19" version="1">MVSDETYELCLPILQDPNLDDEEKTDKLEELLKEKTTLSGQALENAILDALWRFRDGGTNATSPPAIRHSILRRPSPAPWRGSGTPVSGSPRLGVSPLAPPGFMHSPFGRTKSSTASPFGSPRPSPRLAFAAPVPHSPSLSAYQFATDVTPCQEVFGDYQSDNVDWLVSDDAVSVTSSIGGTFSTGGGLGTTSTGTTSSASASGLNVAAPEFVSQRDQHQQQADMTPLDMLRSILGQSKTDEEITQALAAHGYDLGATISAFMEQQQREQQSEADGKEGNNNNSSGSSKVVIGKAMTPNGRPATPAEQPPTKTGVICKYFLSTGQCLRADCRFSHDLSSHLCKYWLAGNCLAGNTCIFSHDPAHLINRLNMDGTNTPPTQHATVNLQDYNSFPALQPGTPEQYGYTLGVAPPPGFRHHERPRSRPGSRHQHKDNNSNNNNTQTAPSPDDADAFPSLGSVVVKQAKKHGKRGGHGHGSGSSNKDGNSSGAPTTLADVVKMSPSPSPSAQKSKAARNGGNSAAASTRNSMENSAAAQAIPPPKHIPWLETGERANKGYLKARAEAIKHGGLRNKFLQSAAQAWNRNDARAAKALSLRGQSENDLMRKAHREAARQLYEDRHKPVDQCPEIYVDLHGLHPEEAVEYLESVMTECSEETRPIYVITGTSGPTGGGGKGSGGGKDKVGKAVRNWLNEWRFAWREFAVPGDGRGTNSSGAGAGAGSILGVDARSWDRGLSVDGGSFKRRENDTEGNGEVNNKEKEKDKEEGSQVQDLLAQGVEIGEGKVKLLVRDTSSSSSSTTTTTTTHATGGGKEKEVLKGPAGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
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                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGS17410.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="92" mass="9773" checksum="A0F5A3808D2198A8" modified="2011-10-19" version="1">MLAITSRTLAARMAPMRLARGFGTSSARQNAASGISVSPLPPRKPIGALRGGLFGFFLGTTAAGAGVYYYAVQEYKASNELLTEDIYVRLCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHC4</accession>
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            <taxon>Chaetomiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
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            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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    </dbReference>
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            <end position="174"/>
        </location>
    </feature>
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            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
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        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="191" mass="20355" checksum="8C4B3570800FFC28" modified="2011-10-19" version="1">MTSNTPQQADTRLEAPTSSATAKSPRLEEKSSQDTIAASTTEPFPTFEDKEAGGIPRPSDVSTVVTPRAHGNPFETDIEAAAAGAVTYDKPRTSGISNVGTWRKSCGAIECTTGGSDCQVWPGQDHWKRKAKAAKKKRHTCNCMANMSKRTRVVVKILILLLIVGLAVGVGFGVSKPLGAGIWKSSTQNQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHJ4</accession>
    <name>G0SHJ4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0070230</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
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            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697301.1">
        <property type="nucleotide sequence ID" value="XM_006697238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHJ4"/>
    <dbReference type="GeneID" id="18261061"/>
    <dbReference type="KEGG" id="cthr:CTHT_0070230"/>
    <dbReference type="HOGENOM" id="CLU_2158093_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="111" mass="12561" checksum="5E436B4AEDA976E1" modified="2011-10-19" version="1">MYLHINEEPTAAITARTIGYWHFPDTQRTVPNEERSSLREDYVRGYSYMTMADWDTPDMPMRIPREPPTKPPGEESVVWKFALVMATAVAGAVAVLSLAVFFLIGRRTGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHL6</accession>
    <name>G0SHL6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0070470</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WHI5/NRM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697323.1">
        <property type="nucleotide sequence ID" value="XM_006697260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHL6"/>
    <dbReference type="GeneID" id="18261085"/>
    <dbReference type="KEGG" id="cthr:CTHT_0070470"/>
    <dbReference type="eggNOG" id="ENOG502T64N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_550937_0_0_1"/>
    <dbReference type="OrthoDB" id="5345625at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013734">
        <property type="entry name" value="TF_Nrm1/Whi5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08528">
        <property type="entry name" value="Whi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="251"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="351"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="411"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="441"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="468"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS17705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="495" mass="53380" checksum="EEEFAA03296C4640" modified="2011-10-19" version="1">MDAPTSPAKRRVLGELNPNAASPKACRRTDLKLAGASPTKQQLPRSPIKMKLAPPTIEQQNASPSRKLRQPQKQHMEAEESPKKRRSPSPVSQQAVTESSRQDAERDEVVEPPAKRPCLQQSAEGQQGAQESVKSQSPPPSSIPSTIIDTGRSRAASPESPSVFDATAANDTTVLTEPETAAAPAAPASAIAPAIAVPRIPDIPRPAPYIAAKSSYPVEKPQKPRLTREQCREKAEILRLRLGLASYKVRTGQTEVPLEQLEKKFLPTPQNQQSSSPRGHPHAHPHPQAWHPQAGSGQYRPPNTGGSSSFMVAATPKRTPLPEAPVRRNSVPYQYQGGYAQYHHQYQAHPAYVQHSRSHSSRLSHRPQPSRYYPRGESDPLPRITEESESRYGHLVPRRASYAGPASVSTPAPARAGSPSAGAAPQSEGVNIRRRDRLELLTDLGNSSSNNSSGSSSSSNSSSSSSESENEDEEFDEEGGAASGLLRLARGKLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-12-14" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHV1</accession>
    <name>G0SHV1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0073470</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697603.1">
        <property type="nucleotide sequence ID" value="XM_006697540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHV1"/>
    <dbReference type="GeneID" id="18261385"/>
    <dbReference type="KEGG" id="cthr:CTHT_0073470"/>
    <dbReference type="HOGENOM" id="CLU_1937921_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="130" mass="14575" checksum="104D61B4758AE7A2" modified="2011-10-19" version="1">MTLPASTLKCFQTPRVYPRELTNRIYECLTAYISVIKAEPESHVHDLQKVNSSTPPEDIPYTIYRTKEAARCAAKQLSILRRWASKENVVLGATSRFEDRSPTRSFRSGPAAEPKNPVKTGAELTVTHNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>G0SI64</accession>
    <name>G0SI64_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0074660</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697716.1">
        <property type="nucleotide sequence ID" value="XM_006697653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SI64"/>
    <dbReference type="STRING" id="759272.G0SI64"/>
    <dbReference type="GeneID" id="18261504"/>
    <dbReference type="KEGG" id="cthr:CTHT_0074660"/>
    <dbReference type="eggNOG" id="ENOG502RIXY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006173_0_0_1"/>
    <dbReference type="OMA" id="IRCDGRP"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF4">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="58"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="661"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="747"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="675"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="700"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="752"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS17134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="911" mass="101192" checksum="AF1756C5A44184F5" modified="2011-10-19" version="1">MPQSRQTNKRPGTAGDTALANAESAAPKPKLPRVERSPSDFSSVVKSKLQSYTRTGQACDRCKVRKIRCDALPEGCSHCTNQNIECYVTDRVTGRTERRGYLQQLEREKGAMLVHIRELEKLLESNGIEVRPWQWPGYTTTYPSAVTYDAISNPVQNPASKDEWTQVGLVWVKNYRQKPQITLGDYIPFSALESRRTDSYLGVAEDNALLSSIKGTKLSILGTVIDIASFESPDTDEPPPETPIGWPLYNKSVMAFLQSILRVNPPPEHIELPPKPDAFTYAEWYFLAVSPFLPVLHKPSFFRLLTRIYDEGYKPTIPELVTVHMVFATMWFQYGIRNREEPERYAQLNELSNRHYHWCLSKFFDLAISPTLTAVQALAMIMVHTRNFPKPACSSTIAQYAFIKALELNLHRRVKMPNNTTTLENEMRKRVWWVILAVMVTLSGRLGRPMPISLHEFDVDFPIPIEDEYLGEEGILDHSQVGRCSWHVGLMGFKVVPLYMEMYTKIYGVRCDPRRYVQVVQDLDAAMDKFIESLPTELRLETYRDPNRQNDPVCMSNDPKVIAENSRICEETVKELLKVVKEVQRKKSLDTTWYQLAVYLAALFSLLVAHWQRRFDVTEAEVAALREDARAWLSIIAEIGRQMGAGSRLAADVGGIIDRTVGSIEQDMRKPGPPSDSSTGTMKSESPAPYPQPVARQNDPPANSVPSTATAPIPRHHVQRDAIATNGSSYYDSNISSPQYASVAYSSQAASGTPSHPNPSNQGGSIDSTQYLYAAASAATTTAAPTTTAAVSESAVQATNPLIAFASQATQHVAGQAANNWSAQTQFMAQTAAITNAWHDWAAAMTDNRATSMPGNQDRFSATTLLTLGTGRPADVGACTMVEHVNQPPDPQTGQWPLLLFHNGGGSVSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G0RXX7</accession>
    <name>G0RXX7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative adrenoleukodystrophy protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0004650</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691005.1">
        <property type="nucleotide sequence ID" value="XM_006690942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RXX7"/>
    <dbReference type="STRING" id="759272.G0RXX7"/>
    <dbReference type="GeneID" id="18254503"/>
    <dbReference type="KEGG" id="cthr:CTHT_0004650"/>
    <dbReference type="eggNOG" id="KOG0064">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007587_5_0_1"/>
    <dbReference type="OMA" id="DIQAGHF"/>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF69">
        <property type="entry name" value="PEROXISOMAL LONG-CHAIN FATTY ACID IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="461"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="677"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS23763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="711" mass="80866" checksum="B253C0B2EF00EC3E" modified="2011-10-19" version="1">MAPSMSKPAVLGRSMTVSTRAIRDLVQRLLQVYLRNRSRISKAIYIALFISFLNRIRNVVIRQKAAAKRANESKSTSSSADKKAELNWEFVRSLLKLIRIIIPSWRSPEARMLLTHSLFLVARTLLSVKVAAMDGSIVKSLVSGHGREFLTKLGWWMVIAVPATFTNAMLSYHQAELALRYRARLTEHLHDKYLSHLTFYALLALDDRIKNPDQLIGVDVSAFATCLSELYGNLAKPILDMVIYTYSLSRNVGGEGVLFMAFLVQLSSQVMRALTPPFGKYVADETRLEGEFRFAHSRLIDHAEEVALYAGHEAEKNTLDKGYFTLIKHINFVLRRRFYHGFMEDFVVKYFWGALGFALCSVPVFIKLPGQTLATMADRSESFITNRRLLMSASDAFGRLMFSYKEVMQLAGYTSRVSTLLDVMDDIKAGHYEKKLVSSSGTANNAAVLKGRGQVIESDYIEFINVPIISPNGDVLVPALSFRIAEGDHLLIVGPNGCGKSSLFRILGGLWPVYGGTVKKPSADKIFYLPQRPYIPRGTLRHQIIYPDTQATMHSRGYTDADLLAILQILNLEHLVEMHPDGWEYEAEWRDLLSSGLQQRVAMARLFYHRPRYAILDECTSSVTLETEKIMYDTAKKLGVTLMTVSHRRSLWKYHTHILQFDGQGKYVFTRLDAERRMRLEDEKEELEVKLRQVPELERRLEELTGEKVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G0RY05</accession>
    <name>G0RY05_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0004950</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Elife" volume="11" first="e80901" last="e80901">
            <title>Structure of the HOPS tethering complex, a lysosomal membrane fusion machinery.</title>
            <authorList>
                <person name="Shvarev D."/>
                <person name="Schoppe J."/>
                <person name="Konig C."/>
                <person name="Perz A."/>
                <person name="Fullbrunn N."/>
                <person name="Kiontke S."/>
                <person name="Langemeyer L."/>
                <person name="Januliene D."/>
                <person name="Schnelle K."/>
                <person name="Kummel D."/>
                <person name="Frohlich F."/>
                <person name="Moeller A."/>
                <person name="Ungermann C."/>
            </authorList>
            <dbReference type="PubMed" id="36098503"/>
            <dbReference type="DOI" id="10.7554/elife.80901"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.89 ANGSTROMS) OF 1-500</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VAM6/VPS39 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691033.1">
        <property type="nucleotide sequence ID" value="XM_006690970.1"/>
    </dbReference>
    <dbReference type="PDB" id="7ZTY">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.89 A"/>
        <property type="chains" value="A=1-500"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RY05"/>
    <dbReference type="SMR" id="G0RY05"/>
    <dbReference type="STRING" id="759272.G0RY05"/>
    <dbReference type="GeneID" id="18254533"/>
    <dbReference type="KEGG" id="cthr:CTHT_0004950"/>
    <dbReference type="eggNOG" id="KOG2063">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004190_1_1_1"/>
    <dbReference type="OMA" id="EDMRIGP"/>
    <dbReference type="OrthoDB" id="10260443at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019452">
        <property type="entry name" value="VPS39/TGF_beta_rcpt-assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF49">
        <property type="entry name" value="VAM6_VPS39-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23556">
        <property type="entry name" value="TPR_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10366">
        <property type="entry name" value="Vps39_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="18"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="4">
        <location>
            <begin position="761"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="47"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="473"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="898"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="56"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="480"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="532"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="909"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="930"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="950"/>
            <end position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS23791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="7ZTY"/>
        </source>
    </evidence>
    <sequence length="999" mass="110357" checksum="2F468C765ECB6969" modified="2011-10-19" version="1">MLSAFTARPIIELKPRDKSRIECILAYGDRVLVGLNTGSLRVYRVNDLSPSPSPANPSDSQSPEASQSSVNPDPSSSTQDPSSQPDSQPVVPQQKPTDLLREIERFSPRAIEQLAIIKEANTLVSLSNYCVSLHDLHTFEPIASPLPRTKNASGFAVTSNIVKDPATGIPEIISRLAVSVKRRLLLWSWHESELEEEVKEVVLTESIRSMTWACATRLVCGMNSGFVVVDVETGTVEDILGPPGGAAGGNQGRWGAVSAGGMGYMGLGGYMPKPLCTKLADGQLLLAKDVNTLFIDDTGKALEKRQIPWQAAPDGIGYSYPYILALQPPAKGCLEVRNPDTLSLLQTLSLPGAAALHFPPPTVSLAHAGKGFHVLSDRVVWKMDATDYDSQVEELVRGGKLDEAISVLTMLEDALLKNKTETLREVKMQKAEVLFRQKKYRESMDLFNEDEVNAPPERVLRLFPKSIAGELSGVEEEKQGQSQQSDSEQEGSSNGTATADQQQQERPKTPDVAEVSSTPKTGGFARYLMRTRTLNPETASIASSKKGSDDDATSIKGKPIDEQAQSEKDLMSAVLELNSYLAGARARLQRVLDPVTGKLKPRGTNTQTDEAFKALLLSNPHLQGADDAQLEAHLQHTFRVIDTSLFRAYMFSRPTLASSLFRIPNFCDPAVVNERLIEQNRFHELVDFFYGKKLHREALNLLKRFGACEEPDPLCPTLHGPQRTVLYLQGLPASMVDVILEFSEWTLRKDPDLGMEVFLADSENAETLPRERVMRFLGGIDIGLEVRYLEHVIGELGDANPEFHNRLVELFIKQLSTMEKGEKWEGTMERLVRFLRESKQYSLGRARGLIPKDDPAFYEAQAVVLSNMGQHRQALMIYVFKMKNYGKAEEYCNRIHKTLESPPQPSGMPISNHSISSPSPSAPSSPPASTLNQPISPSSENRRRETHNLPHPPLPLPFPSRPRSLPPFVSSPVPPLQTWLPPARNPLPLLSHPRHTTCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0RY75</accession>
    <name>G0RY75_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS5m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0005690</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691103.1">
        <property type="nucleotide sequence ID" value="XM_006691040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RY75"/>
    <dbReference type="STRING" id="759272.G0RY75"/>
    <dbReference type="GeneID" id="18254607"/>
    <dbReference type="KEGG" id="cthr:CTHT_0005690"/>
    <dbReference type="eggNOG" id="KOG2646">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037994_1_0_1"/>
    <dbReference type="OMA" id="IYEMCRA"/>
    <dbReference type="OrthoDB" id="309483at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000022">
        <property type="entry name" value="28S ribosomal protein S5, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000041">
        <property type="entry name" value="37S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277:SF1">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="10">
        <location>
            <begin position="326"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS23861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="490" mass="55303" checksum="E92E828E4872A960" modified="2011-10-19" version="1">MSVARPVASRLIFGRLAPAPASSLCTAATVAGPSTTTASVTATTPAPCHHQRIFAHHFHSSPQLAARRKPRFSSIRAAEMGLVDDKKIDEFAKEHFPKYTDKDFEELSHQYSAKHLEAIKAAEEAIDPRDLTIQGRLRVDPYTMQYIDDFAEYQPMIDKRPQNKMPPDPHARFMNLDEFTRDLVDWAEQFQQGDVTGKLKTLYDFVPEEWKTKHEAQWPNEVKQKAHREFQKYLQAEVERQMKNPDDNDGPTDADILQYIFERSAMTDNNLQSNSSVAYGLPKPLPGVAGMYKKPIDPADEGLDDSGVYQDLKRRTGMSVREILNIQTRCIVSRWVANQTRLGKIRKSSVVWIAGNGNGWLGIGEAKSTEASVANLKARLNAIANMRPIRRYEDRTIYGEVQAKVSGTIVKMAARPPGFGLRVSHRIFEMCRFAGIKDLAATMPRSRNPFNSVRAAYQCLLKQRDPEEIAMGRGRKLVDARKVYYGGAVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G0RY94</accession>
    <name>G0RY94_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDB1- and CUL4-associated factor 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">WD repeat and SOF domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0005890</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2017" name="Nat. Struct. Mol. Biol." volume="24" first="954" last="964">
            <title>3.2-A-resolution structure of the 90S preribosome before A1 pre-rRNA cleavage.</title>
            <authorList>
                <person name="Cheng J."/>
                <person name="Kellner N."/>
                <person name="Berninghausen O."/>
                <person name="Hurt E."/>
                <person name="Beckmann R."/>
            </authorList>
            <dbReference type="PubMed" id="28967883"/>
            <dbReference type="DOI" id="10.1038/nsmb.3476"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.20 ANGSTROMS)</scope>
    </reference>
    <reference evidence="15 16 17" key="3">
        <citation type="journal article" date="2019" name="Mol. Cell" volume="75" first="1256" last="1269.e7">
            <title>Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration.</title>
            <authorList>
                <person name="Cheng J."/>
                <person name="Bassler J."/>
                <person name="Fischer P."/>
                <person name="Lau B."/>
                <person name="Kellner N."/>
                <person name="Kunze R."/>
                <person name="Griesel S."/>
                <person name="Kallas M."/>
                <person name="Berninghausen O."/>
                <person name="Strauss D."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="31378463"/>
            <dbReference type="DOI" id="10.1016/j.molcel.2019.06.032"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.50 ANGSTROMS)</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat DCAF13/WDSOF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691122.1">
        <property type="nucleotide sequence ID" value="XM_006691059.1"/>
    </dbReference>
    <dbReference type="PDB" id="5OQL">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="d=1-446"/>
    </dbReference>
    <dbReference type="PDB" id="6RXT">
        <property type="method" value="EM"/>
        <property type="resolution" value="7.00 A"/>
        <property type="chains" value="CM=1-446"/>
    </dbReference>
    <dbReference type="PDB" id="6RXU">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.50 A"/>
        <property type="chains" value="CM=1-446"/>
    </dbReference>
    <dbReference type="PDB" id="6RXV">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.00 A"/>
        <property type="chains" value="CM=1-446"/>
    </dbReference>
    <dbReference type="PDB" id="6RXX">
        <property type="method" value="EM"/>
        <property type="resolution" value="7.10 A"/>
        <property type="chains" value="CM=1-446"/>
    </dbReference>
    <dbReference type="PDB" id="6RXY">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.70 A"/>
        <property type="chains" value="CM=1-446"/>
    </dbReference>
    <dbReference type="PDB" id="6RXZ">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.40 A"/>
        <property type="chains" value="CM=1-446"/>
    </dbReference>
    <dbReference type="PDBsum" id="5OQL"/>
    <dbReference type="PDBsum" id="6RXT"/>
    <dbReference type="PDBsum" id="6RXU"/>
    <dbReference type="PDBsum" id="6RXV"/>
    <dbReference type="PDBsum" id="6RXX"/>
    <dbReference type="PDBsum" id="6RXY"/>
    <dbReference type="PDBsum" id="6RXZ"/>
    <dbReference type="AlphaFoldDB" id="G0RY94"/>
    <dbReference type="EMDB" id="EMD-10051"/>
    <dbReference type="EMDB" id="EMD-10052"/>
    <dbReference type="EMDB" id="EMD-10053"/>
    <dbReference type="EMDB" id="EMD-10054"/>
    <dbReference type="EMDB" id="EMD-10055"/>
    <dbReference type="EMDB" id="EMD-10056"/>
    <dbReference type="EMDB" id="EMD-3847"/>
    <dbReference type="SMR" id="G0RY94"/>
    <dbReference type="IntAct" id="G0RY94">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0RY94"/>
    <dbReference type="GeneID" id="18254627"/>
    <dbReference type="KEGG" id="cthr:CTHT_0005890"/>
    <dbReference type="eggNOG" id="KOG0268">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033999_0_0_1"/>
    <dbReference type="OMA" id="EDHNAYI"/>
    <dbReference type="OrthoDB" id="10249065at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001074">
        <property type="entry name" value="Probable SOF1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007287">
        <property type="entry name" value="Sof1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051733">
        <property type="entry name" value="WD_repeat_DCAF13/WDSOF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851:SF0">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA U3 SNORNA ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04158">
        <property type="entry name" value="Sof1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="14 15 16" id="KW-0002">3D-structure</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="62"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="279"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="322"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Sof1-like protein" evidence="11">
        <location>
            <begin position="355"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="417"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="433"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS23880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="5OQL"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="6RXT"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="6RXU"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PDB" id="6RXV"/>
        </source>
    </evidence>
    <sequence length="446" mass="50787" checksum="6552B64C3CD282B5" modified="2011-10-19" version="1">MKIKALTRSITAQQAPGSDVQRAPRNLAPELHPFERAREYQRALNAVKLERMFAKPFLGQLGNGHVQGVYSMCKDKNSLNCIASGSGDGVVKVWDLTTRDEETWRVAAHNNIVKGLTFTNDKKLLSCATDGIKLWDPYASPSNTTPIATWQEGGPYTSLSFHRSANTFAASSGQGCIRIWDLEHSTAGQAIQWPSFVDTITDVCFNQVETSVIGSVATDRSIILFDLRTNMPVIKTVLHFACNRIVFNPMEAMNLAVASEDHNIYIFDARNFDKALNIQKGHVAAVMDVEFSPTGEELVSGSYDRTIRLWRRDAGHSRDVYHTKRMQRVFRTMWTMDSKYILTGSDDGNVRLWRANASERSGVKATRQRQALEYNNALLDRYGHLPEIRRIRRHRHLPKVVKKATEIKREELAAIKRREENERKHSNKKYEKRKSEREKAVLVKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYA0</accession>
    <name>G0RYA0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0005950</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691128.1">
        <property type="nucleotide sequence ID" value="XM_006691065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYA0"/>
    <dbReference type="STRING" id="759272.G0RYA0"/>
    <dbReference type="GeneID" id="18254633"/>
    <dbReference type="KEGG" id="cthr:CTHT_0005950"/>
    <dbReference type="eggNOG" id="ENOG502S7YV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070882_0_0_1"/>
    <dbReference type="OMA" id="EPAYPIG"/>
    <dbReference type="OrthoDB" id="9936937at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058841">
        <property type="entry name" value="HTH_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040554">
        <property type="entry name" value="KPWE_PEX14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36855">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36855:SF1">
        <property type="entry name" value="PEROXISOME MEMBRANE ANCHOR PROTEIN PEX14P N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25871">
        <property type="entry name" value="HTH_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17733">
        <property type="entry name" value="KPWE_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEX14-like helix-turn-helix" evidence="3">
        <location>
            <begin position="31"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxisomal membrane protein PEX14-like KPWE" evidence="2">
        <location>
            <begin position="167"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS23886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="254" mass="28511" checksum="BD9AA6E776B3E444" modified="2011-10-19" version="1">MNTNSVINPGQGLPVDPNSIPASLTNDPEGFKKFDSYPWEKDRQFLQGLNASLGPIISNQHDMFMRQKALSITLQSRIWWYKSHFGCQIDRIKYEAWTLNHPETNPDHKILKKLDEIRKIMGLPPAVPVPDPDVTKNIPEWQLNAPKCDLSKKAEDVGGRSTEGGAPYPEDFQALVEAVTQGKPIPGIREIPNKVVRPPGISPYGKAPAPPKPWEKNRAGENTQKEWALQGVCDKEFPPLEEDNSNDTTEKKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYE8</accession>
    <name>G0RYE8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0006440</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691176.1">
        <property type="nucleotide sequence ID" value="XM_006691113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYE8"/>
    <dbReference type="STRING" id="759272.G0RYE8"/>
    <dbReference type="GeneID" id="18254682"/>
    <dbReference type="KEGG" id="cthr:CTHT_0006440"/>
    <dbReference type="eggNOG" id="KOG0393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_21_1_1"/>
    <dbReference type="OMA" id="RTKRTCI"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032506">
        <property type="term" value="P:cytokinetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04132">
        <property type="entry name" value="Rho4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000678">
        <property type="entry name" value="Rho GTPase Rho4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS23934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="291" mass="31938" checksum="0D8CF84FC4B50925" modified="2011-10-19" version="1">MASYDHRPSTALGHNRHDSTFSSSSARMRPESRRDGRGLRSSDGTVSTTGTTSSSGRDSANTAATEGPAYSKKIVVVGDGGCGKTCLLISYSQGYFPEKYVPTVFENYITYPVHPPTGKIVELALWDTAGQEEYDRLRPLSYPETDLIFVCFAIDCPNSLENVMDKWYPEVMHFCPYTPLILVGLKSDLRYKKSCIDMLKSQGLTPVTPEQGMAVAKKMGAQYMECSSKEMKGVEEVFERAILTVVANDRKTLEAEAAASGKKGKDIGITYTSDGVPIPIVKKKKRKCALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYK2</accession>
    <name>G0RYK2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Septation initiation network scaffold protein cdc11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0006990</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691230.1">
        <property type="nucleotide sequence ID" value="XM_006691167.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0RYK2"/>
    <dbReference type="GeneID" id="18254737"/>
    <dbReference type="KEGG" id="cthr:CTHT_0006990"/>
    <dbReference type="eggNOG" id="KOG0531">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002093_0_0_1"/>
    <dbReference type="OMA" id="ATSWGTD"/>
    <dbReference type="OrthoDB" id="7451790at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061499">
        <property type="term" value="C:outer plaque of mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902412">
        <property type="term" value="P:regulation of mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031028">
        <property type="term" value="P:septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052574">
        <property type="entry name" value="CDIRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47566">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47566:SF1">
        <property type="entry name" value="PROTEIN NUD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="209"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="553"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="633"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="833"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="931"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1035"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1180"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1255"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1862"/>
            <end position="1953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2009"/>
            <end position="2030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="259"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="398"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="438"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="554"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="583"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="656"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="680"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="732"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="748"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="853"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="944"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="968"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="991"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1037"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1061"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1258"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1268"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1292"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1880"/>
            <end position="1889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1894"/>
            <end position="1906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1909"/>
            <end position="1922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1931"/>
            <end position="1948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2010"/>
            <end position="2021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS23988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2030" mass="223061" checksum="AAF5575C23649C76" modified="2011-10-19" version="1">MGPAWLDSLDEDWVSQPGSPIDASFADLAPSPSPKPQLRPKAAARSSKIPRPSPRGKKGLQQHGADNSISSSPNGNTSVLNERNLHLHERRTAALGHSRKHTPSKLSREIYPGSSNNSDGNNTSNASRSHSCSSNNSSANPGKSGVRDCQACRSASASSTASVIRRPMLRKSGGAANVRGTGDTPEWKRRLVYGELSYGEQRDLFTSAGTGLENIFKPPPTTTPSTRPTTAVTEKMEESPQPQTWNNDEQHEQEDDEHEHEFELEPEHEHEHEHEHEHENDHEEHEQDQEQEEQDQEHEQESDHNEPEPSEEYPEPQSHPRVTFSARPPPVYPPDASPEPNAAHDDDKFSRSPTESPPQPPPPRRGPRQIRYRRTSSESDRSPSRRSPSPDGMPPADQNHQQQPIPPAINTSSPAVPPPKPAQHLNVPSDILSNGGDDGSRKVSGRSDIRNEDFSPIILERLQASDGRTIAFQPMELPPEELKRRLQRLRQRQNQMLFTGDARSETGSLMGIVETSEDLERLGRYVNFKRGSREVDSFRMEGLSEALNEISELNPETSLQASTPKKFPSVRSERPEEEENDPAFDKSPDQSPPREEKRAGLAVGPGNSPLKLFQPYDTFTSQTLMRRLSQFHEPAGDGEANGSTYSPGAKEGESPPRNQSHGRPRQVSTSRFGAGELDGYEFHEDEFSHLDHSGGMDGDKENRGPYRQLDGDDEYGDSPSPNQKFQPIFDLSHTNSPSDQADSQFVLPRRRGKSRRRTARASLPVYPSGATELPLSTPHRRRDAMNEPKRPRTSPCKYDPTPKRRRTLHRSDIAYGIEDGRLLLGGEQQLQLEHEQTPSPGQHSPDQDGGITRSGTPSPPQRASATTHPVDFEVRPLRASRLGGQPPTGPTALPPGSAMMETNRKPSIKTEDFLHEANKIMAMIRSKAGLQTGRGLGSVEEEGEGMKESDEQQEGQREEQGEGDMSFESDKEPFSRPPSREGRPPLPRRSTRQEDPVLAEQLKKYEEGDDGMGDVVASMRSGGLRQSAMLNSMAKRQQLWMQMQGSQLQQPPQPQQQSPHDSFDRHSSWDSRATRTWLSNTPGAAAVMGNLPQVKIIPPNNGWPSPQPSGPHNEEGPAPSSRHVSGASALSVSMLRAGSSRGSNPNDARKTIAPESVSHLIPDQVGDMVLDRERQVWVKRKTSAAGGPEQNGVKGKVSVEESEDEEDPFAGIPDLSVDMTSEMLNLKPPAGLGNEKGRDPRKLAFSSPLAEVIVDQRSLGTATTTDETGSQPPSGSTPSVVNRPLPAGYETIASTRSNGSRPTVPMRQFSVGGETQTARPVSRIDERSEESEDQGNVGLAAGAENLVLPPEENSKGMELSLVGDMSMSVVSPERGGDKEKGKNPAAVTGDQTLSLLVATPPVGRNTKCPVVEADPVAVLNTYVGNLSLSPLSTFTIHRPNESLPLEASYVVGNHRFATGNPEGKRTVSLSVQELVAKLAEVEPFEPYWEDMKELDLRRKGLTAVHALEEFCPKLRTLDLSHNRIRNLGGIPGTVLHLRAMENLLSDLTAWSHLQNLQYLDVSGNDLTTLSPLQHLVHLRVLKADNNRLASLDGIKFHRYLQSLRARNNALTVLDLSSSTMNELATLDLKHNRISRVTGLARLPALTTLNLAHNNLTTFAVDDTDGPCPALKYLHLSDNHLVSLSLANLPHLRLLHADRNNLIQLDNLNPRSCRHLDSLSLREQHGEKGLDVTHLLARAFEVRKLFLSGNLLSKGFVPRTDMLNLQVLEVANCGLVQLPEDLGLFLPNLRVVNLNMNALKSIEGLKGAGRVRKVFVAGNRIGDLGKLVSVLSSWRGLRVLDVRENPCTGGFYKLGALAVAKGKKGKKRDVSGSSAAATEETATKEPDTPKDTPFPSLPDDPALPPLDPQHNSEDDPHDNHNSDSESSDLDASPSQSFTLPDQSPTQDSSFRARLDMDTRVRRRLYEALLASRCPGLRKVDGLGFDAKRMGTPRDGDEVWRVIRERGLIRGDTNQNGEGTTKSRWGVEDSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYY5</accession>
    <name>G0RYY5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0001020</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690655.1">
        <property type="nucleotide sequence ID" value="XM_006690592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYY5"/>
    <dbReference type="STRING" id="759272.G0RYY5"/>
    <dbReference type="GeneID" id="18254140"/>
    <dbReference type="KEGG" id="cthr:CTHT_0001020"/>
    <dbReference type="eggNOG" id="KOG3925">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017233_2_0_1"/>
    <dbReference type="OMA" id="FFPIHKD"/>
    <dbReference type="OrthoDB" id="361029at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18086">
        <property type="entry name" value="HsC9orf114-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003750">
        <property type="entry name" value="Put_MeTrfase-C9orf114-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150">
        <property type="entry name" value="CLASS IV SAM-BINDING METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150:SF13">
        <property type="entry name" value="METHYLTRANSFERASE C9ORF114-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02598">
        <property type="entry name" value="Methyltrn_RNA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="333" mass="37126" checksum="8C32E7059AE69F49" modified="2011-10-19" version="1">MMPPNERQTKKRRLDTEDETQKGSRFKPTVPRDWTVSIAVPTSILTDRVTREQKTTTVGRIARAAAIFSIDEIVVFDDSPPDSRLPSVDPDAYTGDTDPGHFMEHLLNYLETPPFMRKVLFPLHPNLKSQGLLPNMDMPHHPHKDEWMPYREGMTIEGKGKGTTVDIGLPTPVTISESIPPRTRVTLKMPVTPSGTPEPIHPAQPRTEAGYFWGFTVRRAPSLSAIFTTSPFPDGYDMSIGTSERGKPLNAAFPSYEQADFKHLIVVFGGPRGLEYAAMNDPELVQMGIQGGRTRELFDHWVNVLPGQGTRGIKTEEAVLVALSGLRRLWDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZ36</accession>
    <name>G0RZ36_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cinnamyl-alcohol dehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0001570</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690706.1">
        <property type="nucleotide sequence ID" value="XM_006690643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZ36"/>
    <dbReference type="STRING" id="759272.G0RZ36"/>
    <dbReference type="GeneID" id="18254195"/>
    <dbReference type="KEGG" id="cthr:CTHT_0001570"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="OMA" id="QGQMKEK"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000191">
        <property type="entry name" value="Methylglyoxal reductase (NADPH-dependent)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS23464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="349" mass="37699" checksum="80169AAEDFECADF2" modified="2011-10-19" version="1">MTKVLLTGGSGFIAAHILDQLLSKGHTVVTTVRSEDKAARIRAAYPEQSASGALTVAIVSDIAQPNAFDEVVAAHSDVEVVLHTASPFHFKFKDPQKELISPAVNGTTGILSAITRFAPSVRRVVITSSFAAIIDEAKVTDPSHTFTEVSWNPVTLADIHNSPATAYRASKTLAEKAAWDFVNSGEGKGKFDLVTINPPMVFGPLAKAQYVSSPEAVNTSNERIVDLVKGRWKTNGTPATGAAIIWVDVRDVARAHVKAGLELGEEVSGKRLFVVSGEFSNAEIARVVKKRFPEFEGVVPDEEGLKTGEIPPEDKRFRWDNSATRRLLGFEWIGLEESIVDAVESIKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZ84</accession>
    <name>G0RZ84_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative autophagy protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0002060</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690754.1">
        <property type="nucleotide sequence ID" value="XM_006690691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZ84"/>
    <dbReference type="STRING" id="759272.G0RZ84"/>
    <dbReference type="GeneID" id="18254244"/>
    <dbReference type="KEGG" id="cthr:CTHT_0002060"/>
    <dbReference type="eggNOG" id="KOG2110">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025895_5_0_1"/>
    <dbReference type="OMA" id="NIAILEM"/>
    <dbReference type="OrthoDB" id="1667587at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="272"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="288"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS23512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="446" mass="47949" checksum="0A0146B37858BE97" modified="2011-10-19" version="1">MAATLNYVTFNQDHSCLAVATSKGFRIFHTEPFAKVFNSEDGHVSIIEMLFSTSLVALVLSPRHLVIQNTKRGSVICELTFPSAVLAVRLNRKRLAVVLEEEIYLYDISNMALVSTIATSPNPNAIFALSPSSERCYIAYPLPKAREDNGERRPAHAPPLSTYVPPTSGEVLIFDALTLKAVTVIEAHKSPLCCVALNSDGNLLATASETGTIIRVFAVPSGQKLYQFRRGTYPSTIYSMSFNLSSTLLCVSSASETVHIFRLVTPQTASSAASRDADIPSSPRANRWSRSLSVDSTDYPGSSVGEVGEPSPNNNGTSSKRSSGSFGSLLRRSSQLVGRSVAGAVGSYLPQSVTEMFDPQRDFASFKIPRPHQNGGRSGALMGGSSAPLRSVVAMSSSSPQVMVVTSDGHFYVYNIDMQRGGECPLVKFVSVLDPEEKLDASAYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZW0</accession>
    <name>G0RZW0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Disintegrin and metalloproteinase domain-containing protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0004400</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Probable zinc protease.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690980.1">
        <property type="nucleotide sequence ID" value="XM_006690917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZW0"/>
    <dbReference type="STRING" id="759272.G0RZW0"/>
    <dbReference type="GeneID" id="18254478"/>
    <dbReference type="KEGG" id="cthr:CTHT_0004400"/>
    <dbReference type="eggNOG" id="KOG3607">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012383_1_0_1"/>
    <dbReference type="OMA" id="YGLQQNF"/>
    <dbReference type="OrthoDB" id="5951731at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04271">
        <property type="entry name" value="ZnMc_ADAM_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.70.10:FF:000003">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034028">
        <property type="entry name" value="ZnMc_ADAM_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF159">
        <property type="entry name" value="ADAM METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13688">
        <property type="entry name" value="Reprolysin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="705"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="7">
        <location>
            <begin position="274"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="6">
        <location>
            <begin position="511"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="425"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00056552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00074021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS23738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="822" mass="87709" checksum="2D7992D82B31E5BC" modified="2011-10-19" version="1">MIFSKALAAIIAVGAGLLQGSLAHSLKRSPLSSVTRLEDAVIHTPSHRVHAHTSFTITFTLPDRQQKVRLALEPNHDIFGADAAIQVLAADGTVRSIEPIDRAAHRVFKGDSFVQQVGSDEWQHVGWTRITVRRDGARPIFDGVFTVHGDNHHIQTKTNYRDTTVTGDPDIDDADDEFMVVWRDSDIQKHGDLKARDAAPICGSDRLEYNRDRSNLFYRSLDEATGESEDTSPWYMSPKMLFGRQFWDNIPGGNGAGVNLISSIGSTAGCPTTRKVALVGIATDCTYTAALKTKEAVQQNVINLVNSASQLYEATFNISLAIQNLTISEPECPNTPPNSAPWNTPCAGVDIEQRLSLFSKWRGQWKDTNAYWTLLTTCNTGPAVGLAWLGAVCQEGSVTRNNNETSAGANVVVRTSTEWLVFAHETGHTFGAVHDCSASTCLDGSVNRQECCPLSRSTCDASAQFIMNPSTGDRITQFSPCSIGNICSFLGRSPNRMSCLTSNRGVTTFTASQCGNGIVEKGEDCDCGGDEGCANNPCCDPQTCKYTAGSVCDPSNEECCTPQCQFMPAGSICRQSTGPCDPQEVCSGTSAGCPADEAAPDGQECGEPGAGLTCASGRCTSRDQQCKTFLSGSVANGNETTSCSSSGCDLSCASPRLGPQQCYVLNQWFLDGTPCEAGGRCYNGVCKGASATKQFVGWFKDNPQIAIPVACVVGGLIFLALVSCCWSCVCGAARRRRSAARSRARAAAMAAAAALPRSRSSHRRGWSSTAVRGGSVSTAPGAMPMGVVGNVGYAPVPTPPANVVTEPYQYTGWERGRSFRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZZ1</accession>
    <name>G0RZZ1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1</fullName>
            <shortName evidence="8">Oligosaccharyl transferase subunit WBP1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0008130</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DDOST 48 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691343.1">
        <property type="nucleotide sequence ID" value="XM_006691280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZZ1"/>
    <dbReference type="STRING" id="759272.G0RZZ1"/>
    <dbReference type="GeneID" id="18254851"/>
    <dbReference type="KEGG" id="cthr:CTHT_0008130"/>
    <dbReference type="eggNOG" id="KOG2754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031804_1_0_1"/>
    <dbReference type="OMA" id="AHDEYPR"/>
    <dbReference type="OrthoDB" id="29105at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005013">
        <property type="entry name" value="DDOST_48_kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055459">
        <property type="entry name" value="OST48_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055457">
        <property type="entry name" value="OST48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23358">
        <property type="entry name" value="OST48_MD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03345">
        <property type="entry name" value="OST48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005130811" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1" evidence="8">
        <location>
            <begin position="19"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 N-terminal" evidence="9">
        <location>
            <begin position="25"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 middle" evidence="10">
        <location>
            <begin position="318"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS23152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="476" mass="52711" checksum="03A886A83A226BA2" modified="2011-10-19" version="1">MRPLRSLLACLFAAGVSALSTSGNRLLVIMDDVSEKESYSQFLGDLESLSYLPCRGFQLSFESPKSESLSLFHLGERTYDHLLFFPTKTKGLGPNLTPNLLVDFVNAKGNILVTLSSGTTAPTSLISLLNELDIQLPADRTGLVVDHFNYDASSSPDTHDVLVLPAPFPVRPDVKDFFSGADVSSPSEKVLAFPRGVGATLGNGPLLAPILRAPRTAYSYNPKEQKETVDDLFAAGEQLALVATFQARNSARVTLVGSAEMLQDKWFDAEVKTKEGKATKTFNREFAKRVSGWTFNEIGVLRVNWIEHRLDEPGAPNNVSNPKIYRVKNDVKYTISLSEYSWTAWQPFTLPPDSDEIQLEFSMLSPFHRLALAPDASLSSDTATAYSVRFKVPDRHGIFNFRVSYKRPFLSNVEEKNTVSVRHIGHDEWPRSWAISGAWPWMSGIGVTVVGWLAFCVIWMFSAPVGPKVEVGKKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZZ3</accession>
    <name>G0RZZ3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beige protein homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0008150</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May be involved in protein sorting and cell wall formation.</text>
    </comment>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691345.1">
        <property type="nucleotide sequence ID" value="XM_006691282.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0RZZ3"/>
    <dbReference type="GeneID" id="18254853"/>
    <dbReference type="KEGG" id="cthr:CTHT_0008150"/>
    <dbReference type="eggNOG" id="KOG1786">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1788">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000175_2_1_1"/>
    <dbReference type="OMA" id="EMSNFHY"/>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01201">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000001">
        <property type="entry name" value="neurobeachin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056252">
        <property type="entry name" value="Alfy-like_Arm-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051944">
        <property type="entry name" value="BEACH_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108:SF4">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23295">
        <property type="entry name" value="Arm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="8">
        <location>
            <begin position="1849"/>
            <end position="1982"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="7">
        <location>
            <begin position="2021"/>
            <end position="2313"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="2447"/>
            <end position="2489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1149"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1739"/>
            <end position="1758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1788"/>
            <end position="1836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1157"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1188"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1741"/>
            <end position="1757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1818"/>
            <end position="1836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00054699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00073334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS23154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="2663" mass="298903" checksum="B9E41594859CB0CE" modified="2011-10-19" version="1">MLALHGRRYRSSTSASAHQTSQATEILHTLLQRLSDTISLPVAGDFPDTKQVIGQAQHVHQHLSALPPPSPPQDDFRHLHGFHVFLNVLRSFAGFYNPNKRTESEKKAVFELLHVVLATFSAAFRGHTGNRRYFQERVEGGGWEALEQTIASIGICGGDVDPWTSCQLFGKLFSFALDDQRLDGFFCSAVTPEPLSTAPDTQNGDQKENAAAAEDGSLVNISLPAVYNIEVIEQRLRAIIAPTTVVQNAEIVRTIVAFWESLPRSPGTAPNLASLMVLETLSLVASASFHNLNALHASGLLSRLLHLLFGEHSPLTEPERTKALCLCRSLMSLGVERLEDAQFLLTRRDVATSEFCLQMAERYTGPPFIHFDLSLHGYSSIELPSLGRSFPPQTAPGYTFTAWIRIDKFDPDSHTTLFGVFDATQTCFLLAYLEKDTRNFILQTSITAPRPSVRFRSVVFQEGHWYHIAIVHRRPKTITASKASLYVNGEFAEQVRAGYPSPPPPTNPSVESFVSFPSTTAKTNPIQAFLGTPRGLAAQLGAGLVHSKWSLASAHLFEDVLSDDLLAVYYRLGPRYQGNFQDCLGGFQTYEASAALGLRNEVFHPGKDENSDILKAIRDKAGTIVPENKVLLSVFPRAVFSPDGKFLDTLLFRSLSRNAASALFHATVKSGTAVALNGAVACVNDALIKLNGVSVLEGRPMVATPCHLDDNLWRLGGFTPVALKLVERSSTGDELLRAVELMFHCISNNWRNSEAMERDTGYAILSMLIRAKLGYGVAGNEALSQAWRLSLTSEARDRLSFQLLSLLLHFVGYKHADPIESFIINPLAYRVLLIDPDTWRRSCTRTQELYYKQFLTFAVKSKHHQFNSRRLLRMRIIKRLLDALKAETISEEIMPHFMASFEALVKCNYSAEVHRSIALFITYAFHTPGSLPRTPKPGSVGNRSATPVSGVVRRQTASSIDPPSLSSSQTSTLLTKKELGIRLLEMYTRLLCEKSNLVDIRKFAKTVTNKVIIEVGPKKKKKEYVLTTRQWLLYLLAESNPKIVVYGCKILARLLVTQPSSYTNKFASKTGGFWIMAHRLKQWWDISTLWPILFSILFGHDVANIDFDKSFDFFSLLEIFGESKVVFPDVLPVITAMLQHGLRDVIKYQDDPDSPAGDSTPTKACQSSLGSVQTRPRARSMELGQALEPRRTQPDKERVAANAGVLQTVVRFLADMHARSANFRDFALTSDYVRLLCSALYPVIVSADPVSAETELNSKDSGLTFEGVDVIIRPVPGSSSNAIPIVRTAGSAPTSDLASTPPSSSRRFPLRRPSSFVLVTAQPPPTAPTRLTPIMSPKKKVATRNISNAVLEGLMELIIGVFTDQILVRKEFPGFSLFLKVPPGFQEHRAYFETYILRNVMTHLKNAIQLEQKLLVEPRILQNLSRLNLHMIEIVFEGWFMNGAETMIDFNGTVLEYLQRPEVASLKSVRLCSSAVQTIKTAFLKFALLRLSDMDDPEIKESEAVAVMEQLLYWQTVLLDSLTLDGEYMKLLWYQLYNKLVDSRHSVRLIASTLWRIMLVQKPDESAALLRQTITPDQRWLARDFEKLTELDDLSFLEWVDENRSSLDVLFLGGMSKAWEDFVVAENQKSGDSAKMRLKHRKDKLRQWHMENLERENVLLRHEMANSAWMKSIYFTEHFKHQRLLQDQQDDNAFMASTFARMERDLRRAGAVFAEPQNIKWKLDRTEGRNRMRLRLLPEYPSQQRQQEFQPKRSNTAAAKPIVVSTKGSSAQGSSATLSASVPTSVAGALDGTAGDPDISVEPELVPGRTEDQSSVAPEEDFEMVEDPNEPDGDDTFEDKNRKVMRRLQQGDTVQNVFNISRIIGLDASEGILIIGKEALYLMDNLFQSSDGEIVNVWQAPPEERDPFSIIITGDRPNERRQNQGRPEQESRSWRWRDVLSISKRRFLFRDVAIEIFFTDGRSYLLTAINPAKRDEIYARLTAMTPHTTNPSLLPNPEDAWRLECLKLSEEAPQSLGAKFGSIFNSSGWHQAMKRWQRGEISNFHYLMLINTMAGRTFNDLTQYPVFPWVLADYTSEELDLTNPATFRDLTKPMGAQTPARAADFAMRYKSLSEIGETPFHYGTHYSSAMIVSSYLIRLPPFVQSFVLLQGGTFDHPDRLFFSIEGAWRSASRDNGSDVRELIPEFFYLPDFLTNINGYNFGVRQGDGGQVNHVILPPWAKGDPKIFIAKHREALESPYVSQNLHHWIDLIFGYKQRGELAVENLNVFHPLSYKGARDLDNITDPQERLITTGIIHNFGQTPHQIFTKPHPPREFYRCPVKRLDSSVHALTRLPYPLLESRERVASLIYVPKLDRLLCASPFRLNLPPHYDKFLEWGYTDNSVRFFLSDNRKPAGMFENLHIGQISTVAFADSKTLITAGEDCVVLVHNVVSQPGKPVVELHLRSSLFGHKTPVTHIAVSKAFSTILTVSAQDGAAFLWDLNRLEFVRRLPPIAPRPGGVGVECAKINDATGDIMICCGQNVLLYTLNGELILDQNVCVPPNASPPANSNKSAGSGANGGWEDDFVHSCAFYEGSGGNEWLENQLVFTGHKRGVVNIWRKTVDDRAGRWVLQHMRRLDHVNPKSETGVNVEAAITCIAPLPTLVYTGDEDGRVYEWNLVQRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0S039</accession>
    <name>G0S039_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CTHT_0008630</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 14"/>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691391.1">
        <property type="nucleotide sequence ID" value="XM_006691328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S039"/>
    <dbReference type="STRING" id="759272.G0S039"/>
    <dbReference type="GeneID" id="18254901"/>
    <dbReference type="KEGG" id="cthr:CTHT_0008630"/>
    <dbReference type="eggNOG" id="KOG3359">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008438_5_0_1"/>
    <dbReference type="OMA" id="MCGWDDN"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23284">
        <property type="entry name" value="beta-trefoil_MIR_PMT2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000012">
        <property type="entry name" value="Protein O-mannosyl-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF46">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="226"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="280"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="600"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="642"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="668"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="699"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="334"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="400"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="464"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGS23200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="740" mass="84840" checksum="301F90FF1D135994" modified="2011-10-19" version="1">MASSDRPAVASGADVGDALRRRNVPGAQPAAAQQQQPQPEEQKKEKKGPSILQVFDEWEWVIAPVIFTALAFFTRLYKIGLSNIVTWDEAHFGKFGSHYLKREFYFDVHARKLLVGLSGWLAGYNGSFEFKSGETYPAEVNYTFMRQFNAFWGAVCVPMAYWTAKELHFKRPTVWLVTLMVLCENSYTTISRFILLDSMLLFGTVATTLCWAKFHNQRKNPFEPEWFFWLFMTGLSIGFVCSVKLVGLFVTALVGLYTIEDLWNKFGDTKMPWSELAAHFFARVVGLIILPFLIYLLSFAIHFAVLTNSGPGDAQMPSLFQANLRGTSVGRDSPLEVAYGSLVTIKNMGYGGGLLHSHVQTYPEGSTQQQVTCYHHKDANNNWFFYPNRHDVPYDPNAPPRFIGNGDVVRLLHAQTGRNLHSHTIPAPITKSQWEVSGYGNLTVGDDKDHWQIEVVKDTASRDYSRIRTLTTAFRLRHKVLGCYLRAGNVNLPQWGFKQIEVTCTKDNNPRDKYTHWNIEQHTNEKLPPGNPSLYKSPFFQDFIHLNVAMMTSNNALVPDPDKQDDLASKWWQWPILHVGLRMCSWDDKVVKYFLLGNPAVYWGSTASLVVFGGLVAWYLIRWQRGYRELSASDLDQIHYAGVYPAVGWFLHYLPFIIMARVTYVHHYYPALYFAILTFGFLADWFLRNRGKVTQTAVFGVLYAVVIGLYIYFIPICFGMTGPNKKYRYMKWFDNWRMSD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-06-24" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0E7</accession>
    <name>NU120_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleoporin NUP120</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Nuclear pore protein NUP120</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">NUP120</name>
        <name type="ORF">CTHT_0009760</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. NUP120 is involved in nuclear poly(A)+ RNA and pre-ribosome export, in GSP1 nuclear import, in NPC assembly and distribution, as well as in nuclear envelope organization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 4">Component of the nuclear pore complex (NPC). The nuclear pore complex (NPC) constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof.</text>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-16069242">
            <id>G0S0E7</id>
        </interactant>
        <interactant intactId="EBI-16069391">
            <id>G0S2G1</id>
            <label>ELYS</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>6</experiments>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-16069242">
            <id>G0S0E7</id>
        </interactant>
        <interactant intactId="EBI-16069276">
            <id>G0SAK3</id>
            <label>NUP145</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>12</experiments>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-16069242">
            <id>G0S0E7</id>
        </interactant>
        <interactant intactId="EBI-16069375">
            <id>G0S2X1</id>
            <label>NUP37</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>8</experiments>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-16069242">
            <id>G0S0E7</id>
        </interactant>
        <interactant intactId="EBI-16069259">
            <id>G0SDQ4</id>
            <label>NUP85</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>15</experiments>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Nucleoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="1">Symmetric distribution.</text>
    </comment>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691499.1">
        <property type="nucleotide sequence ID" value="XM_006691436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0E7"/>
    <dbReference type="SMR" id="G0S0E7"/>
    <dbReference type="DIP" id="DIP-60572N"/>
    <dbReference type="IntAct" id="G0S0E7">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S0E7"/>
    <dbReference type="TCDB" id="1.I.1.1.2">
        <property type="family name" value="the nuclear pore complex (npc) family"/>
    </dbReference>
    <dbReference type="GeneID" id="18255014"/>
    <dbReference type="KEGG" id="cthr:CTHT_0009760"/>
    <dbReference type="eggNOG" id="ENOG502QQWQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003258_0_0_1"/>
    <dbReference type="OMA" id="TLWKNNM"/>
    <dbReference type="OrthoDB" id="67716at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059141">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056548">
        <property type="entry name" value="HEAT_Nup120"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021717">
        <property type="entry name" value="Nucleoporin_Nup160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048884">
        <property type="entry name" value="Nup120_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11715">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23300">
        <property type="entry name" value="HEAT_Nup120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21486">
        <property type="entry name" value="NUP120_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0509">mRNA transport</keyword>
    <keyword id="KW-0906">Nuclear pore complex</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000433179" description="Nucleoporin NUP120">
        <location>
            <begin position="1"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="770"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1128"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="770"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1165"/>
            <end position="1185"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P35729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="21784248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4">
        <source>
            <dbReference type="PubMed" id="21784248"/>
        </source>
    </evidence>
    <sequence length="1262" mass="141834" checksum="86225099E3BBDBCF" modified="2011-10-19" version="1">MAFDNFEILYKETRLNLEPASPSSVVQLRVAPTNAYGRSSLSSSSSSRPASATADDEKGYRTKNLATASSIYYRKHHSSPRGFLWRVLDNNTVLSIRVADVCRQEKVADAPLILNLRFASPLRPACVGFADHEDHDALFVYAIDQSNQLWSIILRPDHFRKRSATEGGLGDASRVYSPPGFGFKHPHRLAVVSPDQLIVTMHDGGILKFDRNKNHESHGSPWRESIYNVAGWGQSLRGLVPFQRNPTVRYEKINMELTAAASTAVTTMGHAETAFLFTICLDHRMRVWDVRTGQILYTGDILNNTKRDPQEVGKWTVDPSQNNLIRILDNGRGQCLVVTYSPVGAGEFKFWKVKANDQGSIHVTDCFPDARLMSPNPTSLDVWTLADFAIAQQPDGPELWALWKNNTSYRVNRLQIIPRNATAPFADGWKAVCVESPGPTPRASGSWNPTDSTEKWLDLIFSPGRFSKSTLETALAMYEKGLGTYKETVSRSGKGIAESICSVIGSTTTLDRSSQGGADYDQFRNTSETQWMRFWRLLLELDKQRGEALSLVFDQYDGMVWVTCADLLAAVRQCSDLERLYHNLQSPEKKNEDVAALISAGLTFVETFSDSMHQLCKAALRAELYENSALSDRERMQLFLDRAGFWVTDEDWAQVLDIVGQNYQMVTSRLYEDLFDLITATSEANSQELREPFTIFGKKVVVRAVQETVELHWQILFSQLILLVNMVDSESEEARPLHTRFDVGSVYRRLIDALRRLEHLRWMTKTELSVSPSKSRSGSSSPTLSKRGQDESYTRTALEELAGHLFGLPESNNMPLLSSITDLVLDLCAPTSTTVLNTWLIQCWLLKEGRPDLALELMPFAEQDPFSTYVQGRVFLALRDYDTAAQHFRKAAIGLSIPLKHVDRHSAGLLDDTEWNLLNSGLPNYYAHIVNLYDKQKAYSYVMEFSRLALQFAQTSNQDSASIKTEMLSRLFTASTATSHFEEAHSALLAMDDEALQKSYLRKLLERMCESGQSSELISLPFSGLQNKVDEILAEKCRATRDVLNGVPYHQILYAWRISHNDYRGAAAILLDRLEKLRRSGEGDKLGAEDGENGAGNDALDTQVTRQYLIVINALSCVAPQEAYILEDVPPPVPGKGTNDEEYSQTGSKRKLGKLNATSGEEDLDSRIEELARLLDSESAGDKKARPSSSSEEDQQLLERMQKFSTAVRQEQGQQTPRRLLRLEDLRKQYQQELDRIVAIQNNQFALTADGEDEDEDMMDIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0W3</accession>
    <name>G0S0W3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glucosamine 6-phosphate N-acetyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0011460</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="2.3.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the acetyltransferase family. GNA1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.4" evidence="8"/>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691665.1">
        <property type="nucleotide sequence ID" value="XM_006691602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0W3"/>
    <dbReference type="STRING" id="759272.G0S0W3"/>
    <dbReference type="GeneID" id="18255184"/>
    <dbReference type="KEGG" id="cthr:CTHT_0011460"/>
    <dbReference type="eggNOG" id="KOG3396">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072095_0_1_1"/>
    <dbReference type="OMA" id="NQRYDWI"/>
    <dbReference type="OrthoDB" id="10039976at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000048">
        <property type="entry name" value="Glucosamine 6-phosphate N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355:SF11">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="9">
        <location>
            <begin position="24"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS22673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="178" mass="20143" checksum="D505FFD80BF77E66" modified="2011-10-19" version="1">MAEKELFPSEYLSPEVQAQLPEGYKLRALRKTDYDAGFLDVLRVLTTVGDIPKEKFEERFDWISKQDSSYFIIVIEDTNSSPPRIVGTGALLVERKFIHQLGSVGHIEDIAVAKDQQGKKLGLRLIQALDYIAKQTGCYKTILDCSEHNEGFYVKCGFRRAGLEMAHYHEGPKSNSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0X7</accession>
    <name>G0S0X7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0011600</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691679.1">
        <property type="nucleotide sequence ID" value="XM_006691616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0X7"/>
    <dbReference type="STRING" id="759272.G0S0X7"/>
    <dbReference type="GeneID" id="18255198"/>
    <dbReference type="KEGG" id="cthr:CTHT_0011600"/>
    <dbReference type="eggNOG" id="KOG1872">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017549_2_0_1"/>
    <dbReference type="OMA" id="FKSDAEY"/>
    <dbReference type="OrthoDB" id="333239at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02657">
        <property type="entry name" value="Peptidase_C19A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16104">
        <property type="entry name" value="Ubl_USP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044635">
        <property type="entry name" value="UBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982:SF1">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="4"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="109"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="373"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="394"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS22687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="549" mass="60712" checksum="24BB068F34626CA1" modified="2011-10-19" version="1">MATVNVIIKHQGKKYDVEVDTTSTGEVLKYQLYSLTGVEPERQKILIKGGQLKDDTDLSKLGLKPGQVIMMMGTPGEGGGAIQRPTEKIKFIEDMTEAEAAQQAGATPAGLINLGNTCYLNATLQALRSIPELQDALSKHKHTSMSEIPQLDITNQLKELFKLMSETQGGLAPLAFLNALRTTFPQFAERSRKGPGYAQQDAEEAWSQIVSQLRQKLKLEIPGEGGASQSVSFVDKYMAGEFSTTLECDDPAALEGGEQPTSSKEAFFKLDCHIDNQTSHLRDGLLSGLTGKIKKRSEVLGRDATYTKTSKISRLPKYLTVHFLRFFWKRDVQKKAKIMRKVTFPHELDIVEFCTDDLKKALIPVRDKVREVRKEEEDIERARKRRKKNPLTDGEAKEANTKEEKKPTASADGDIVMTETYKTDAEWEAEKDASLLAAKKELNALIDPELRKDDGANQSGIYELRAVVTHQGASTDSGHYTAYVKKAAPKDPVTGKVGTEDGNWWWFNDDKISEVTPDKIDALAGGGESHSALILLYKAIPLPDAEGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1D5</accession>
    <name>G0S1D5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0013210</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691837.1">
        <property type="nucleotide sequence ID" value="XM_006691774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1D5"/>
    <dbReference type="STRING" id="759272.G0S1D5"/>
    <dbReference type="GeneID" id="18255359"/>
    <dbReference type="KEGG" id="cthr:CTHT_0013210"/>
    <dbReference type="eggNOG" id="ENOG502S1EZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056292_1_0_1"/>
    <dbReference type="OMA" id="IFRDVMA"/>
    <dbReference type="OrthoDB" id="421671at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025638">
        <property type="entry name" value="DUF4336"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835:SF1">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835">
        <property type="entry name" value="YALI0C07656P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS22845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="32205" checksum="D76DFB4423759CF4" modified="2011-10-19" version="1">MPSKLVPTNPEEVMVIRDVTPNVVTLSVPFARFGKVPIGGRATIVRLTSGALAIFSPVALTLTVRAKLSSLGNNVRYLIAPDIEHHLFLSEWKSAFPDAKLIGPEGLPEKRAKAHAAGSEMIGNEEFDAIVTRENYLNVLGEFGEDFATDFDMEYVSAHPNRELVFYFRPDRVLIQADLFFNLPATEQYSRVPESEKPSPGLLTRMFTSLQTPGSGNPLGMKRFMWYLVSNSRGDREAFNESVRRIGEWDFEVVVPCHGETVVQGGKELFERVFEWHLKAAREKGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1L5</accession>
    <name>G0S1L5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0014030</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691917.1">
        <property type="nucleotide sequence ID" value="XM_006691854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1L5"/>
    <dbReference type="GeneID" id="18255441"/>
    <dbReference type="KEGG" id="cthr:CTHT_0014030"/>
    <dbReference type="eggNOG" id="ENOG502S6PS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_7_2_1"/>
    <dbReference type="OMA" id="LMYMPLH"/>
    <dbReference type="OrthoDB" id="184880at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="493" mass="54774" checksum="CB600482D7719563" modified="2011-10-19" version="1">MADQRALNGSIGGVSVTVTELQPQSNPKKRGRRDDEVSSPTAVESLLTNPEGLKSPIARAVSPQPRTKSPSTVARRPSFAANADGSIHSLPESSPSVPPSLPSDPVTTSVSRPSSVESGGVSTGYPYSNSLPVSGSPTVDTSGLDDNAKRKSANYHDEEEHQAALTQAEEGTIVIDSDDQGTDDGYETDAHTAASTSLAESVRDYVWENGRRYHRFREGRYNFPNDDIEQQREDMKHAMVKLLCGNQLYFAPIGDNPHQILDIGTGTGIWAIEMGDLFPSSNILGIDLSPIQPEWIPPNVRFMVDDVEWLHPRNYFDYVHSRHTVQAIQDWPKLMRRVLEHLRPGGWFELQEVYHYPISQNNSMSPDHPIAKYWGLISEGLGRLGVPFFAVANGGLTNMMRECGFVNVTERVLQIPIGTWPKNKVLKTVGLYWRTILLDGIQAIALGPLTRGLGWTREEVELFLVDVRRAYQDNSILAYMPMHIIYGQKPLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0S243</accession>
    <name>G0S243_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromatin modification-related protein EAF3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0015920</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MRG family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS23103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692095.1">
        <property type="nucleotide sequence ID" value="XM_006692032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S243"/>
    <dbReference type="SMR" id="G0S243"/>
    <dbReference type="STRING" id="759272.G0S243"/>
    <dbReference type="GeneID" id="18255630"/>
    <dbReference type="KEGG" id="cthr:CTHT_0015920"/>
    <dbReference type="eggNOG" id="KOG3001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121546_0_0_1"/>
    <dbReference type="OMA" id="QPPYSKD"/>
    <dbReference type="OrthoDB" id="124855at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18983">
        <property type="entry name" value="CBD_MSL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000149">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008676">
        <property type="entry name" value="MRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053820">
        <property type="entry name" value="MSL3_chromo-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880">
        <property type="entry name" value="MORTALITY FACTOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880:SF15">
        <property type="entry name" value="MSL COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22732">
        <property type="entry name" value="MSL3_chromo-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="5">
        <location>
            <begin position="26"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="86"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS23103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="143" mass="15927" checksum="8A43CA5C9B20889C" modified="2011-10-19" version="1">MPPSKQKPEPPFQKDERVLCFHMDMLYEAKILDIMPAENGEGWQYKIHYKGWKSSWDDWVPQDRVRKFTDENKELAAQLVAQYKALQQGKNSKQPKKGGAKGAAAAASDGNSGRGSEERGAGGTTSSGRGPRRARDYDLEQVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2B5</accession>
    <name>G0S2B5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Flap endonuclease 1</fullName>
            <shortName evidence="15">FEN-1</shortName>
            <ecNumber evidence="15">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CTHT_0016650</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2023" name="Front. Mol. Biosci." volume="10" first="1320648" last="1320648">
            <title>Canonical binding of &lt;i&gt;Chaetomium thermophilum&lt;/i&gt; DNA polymerase delta/zeta subunit PolD3 and flap endonuclease Fen1 to PCNA.</title>
            <authorList>
                <person name="Alphey M.S."/>
                <person name="Wolford C.B."/>
                <person name="MacNeill S.A."/>
            </authorList>
            <dbReference type="PubMed" id="38223238"/>
            <dbReference type="DOI" id="10.3389/fmolb.2023.1320648"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 339-353</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Nucleus</location>
            <location evidence="15">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Nucleus</location>
            <location evidence="15">Nucleoplasm</location>
        </subcellularLocation>
        <text evidence="15">Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14 15">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="15"/>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692167.1">
        <property type="nucleotide sequence ID" value="XM_006692104.1"/>
    </dbReference>
    <dbReference type="PDB" id="8Q7I">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.95 A"/>
        <property type="chains" value="P=339-353"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2B5"/>
    <dbReference type="SMR" id="G0S2B5"/>
    <dbReference type="STRING" id="759272.G0S2B5"/>
    <dbReference type="GeneID" id="18255703"/>
    <dbReference type="KEGG" id="cthr:CTHT_0016650"/>
    <dbReference type="eggNOG" id="KOG2519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032444_1_1_1"/>
    <dbReference type="OMA" id="MGIPWVQ"/>
    <dbReference type="OrthoDB" id="1937206at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09907">
        <property type="entry name" value="H3TH_FEN1-Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09867">
        <property type="entry name" value="PIN_FEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000009">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000003">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00614">
        <property type="entry name" value="Fen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023426">
        <property type="entry name" value="Flap_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF9">
        <property type="entry name" value="FLAP ENDONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="21" id="KW-0002">3D-structure</keyword>
    <keyword evidence="7 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 15" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 15" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 15" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 15" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 15" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="18">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="17">
        <location>
            <begin position="146"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGS22148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="21">
        <source>
            <dbReference type="PDB" id="8Q7I"/>
        </source>
    </evidence>
    <sequence length="395" mass="45246" checksum="67268B9195CCF472" modified="2011-10-19" version="1">MGIKHLFQLIKEEAPLSIREGEIKQHFGRKVAIDASMSIYSFLIAVRSDGQQLMNDAGETTSHLMGMFYRTLRMVDAGIKPLYVFDGKPPKLKSGELAKRFQRKQEAQEDLEEAKETGTAEDVEKFSRRTVRVTREHNAECQRLLKLMGIPYIIAPTEAEAQCAVLARAGKVYAAASEDMDTLCFNTPILLRHLTFAEQRKEPIQEIHTDKVLEGLNMDRKQFVDLCILLGCDYLDPIPKIGPSTALKLIREHGSLEKVVEFIQNDPKKRYTIPEDWPYQDARELFFNPDVRQADDPECDFKWEKPDVEGLVQFLVKEKGFSEDRVRNGAQRLEKNLKGAQQARIEGFFKVIPKTEAEKQAQKRKIEEQIEARKKKAKEEKKEKAKQKAKPRGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2X2</accession>
    <name>G0S2X2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0018810</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692374.1">
        <property type="nucleotide sequence ID" value="XM_006692311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2X2"/>
    <dbReference type="STRING" id="759272.G0S2X2"/>
    <dbReference type="GeneID" id="18255919"/>
    <dbReference type="KEGG" id="cthr:CTHT_0018810"/>
    <dbReference type="eggNOG" id="ENOG502RXTJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044092_0_0_1"/>
    <dbReference type="OMA" id="SIHMIHG"/>
    <dbReference type="OrthoDB" id="674948at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40129">
        <property type="entry name" value="KETOPANTOATE REDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40129:SF2">
        <property type="entry name" value="KETOPANTOATE REDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS22355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="33833" checksum="B21F29FC8B436984" modified="2011-10-19" version="1">MTELLPSVHLLILGAGWTATFLIPLLQQRGIAFAATTTTGRTVAGVPTIPFKFDPNAPDEEITSAIGALPRARYILITFPMKGEGQSRTLVEHYLQTHPPQRGLPKARFVQLGSTGIWGQGGSTVSRSGEGKKGWGWITRHSAFDRANPRAVAEDELLLLGGCVLNLAGLWGGERHPKRWVVRVAGSKEAVRGKTSLHLIHGVDVARAILAVVDVDDEKWEKHGRGQRWLVSDGVVYDWWELLVEWAEEGQEEGKVSEQARWVWELMGEMGVLGLPREKEVLGRCLSSEEFWRTWGLVPLKARVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2X8</accession>
    <name>G0S2X8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">T-complex protein 1 subunit eta</fullName>
            <shortName evidence="9">TCP-1-eta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-eta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0018870</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterooligomeric complex that forms two stacked rings.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692380.1">
        <property type="nucleotide sequence ID" value="XM_006692317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2X8"/>
    <dbReference type="STRING" id="759272.G0S2X8"/>
    <dbReference type="GeneID" id="18255925"/>
    <dbReference type="KEGG" id="cthr:CTHT_0018870"/>
    <dbReference type="eggNOG" id="KOG0361">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_7_1_1"/>
    <dbReference type="OMA" id="HRKGNTW"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03340">
        <property type="entry name" value="TCP1_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000022">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000006">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012720">
        <property type="entry name" value="Chap_CCT_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02345">
        <property type="entry name" value="chap_CCT_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="546"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS22361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="575" mass="62935" checksum="59C2738394B1EFF1" modified="2011-10-19" version="1">MLLEVAKRSKSAAVISRMNLILPEVARAQAARQLELSTDTSQGKGQILSNINACLAVQSTIKSTLGPYGGDLLLVDQNGKQTITNDGATVMKLLDIVHPAARILVDIARSQDAEVGDGTTSVVVLAGEILKEIKEHVEAGVSTQIIIKGLRKAASMAVNKIREIAINTEEGDRIDTLHKLAATAMTSKLIKRNSDFFTKMVVDAVLSLDQDDLNEKLIGMKKIPGGSLTDSIFVKGVAFKKTFSYAGFEQQPKKFIKPKICCLNVELELKAEKDNAEVRVEQVSEYQAIVDAEWQIIYNKLEAIYKTGAKVVLSKLPIGDLATQYFADRDIFCAGRVTSEDMERVIQATGATIQSTCSDIRPEHLGTCGIFEERQIGGERFNFFEDCPEAKTCTLVLRGGAEQFIAEVERSLHDAIMIVKRAIKNKTIVAGGGATEMEISAYLHRYADQTVRNKQQAIIKSFAKALEIIPRQLCDNAGFDATDILNRLRVEHRRGNTWAGVDFQNESVADMMEKFVWEPALVKINAINAATEAACLILSVDETIRNEESKTPPAPGSKPARGGAGRGRGRGMPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G0S336</accession>
    <name>G0S336_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">nitric oxide dioxygenase</fullName>
            <ecNumber evidence="4">1.14.12.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CTHT_0019520</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">In the presence of oxygen and NADH, it has NADH oxidase activity, which leads to the generation of superoxide and H(2)O(2). Under anaerobic conditions, it also exhibits nitric oxide reductase and FAD reductase activities. However, all these reactions are much lower than NOD activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2 nitric oxide + NADH + 2 O2 = 2 nitrate + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19469"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 nitric oxide + NADPH + 2 O2 = 2 nitrate + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.12.17" evidence="4"/>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692438.1">
        <property type="nucleotide sequence ID" value="XM_006692375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S336"/>
    <dbReference type="STRING" id="759272.G0S336"/>
    <dbReference type="GeneID" id="18255990"/>
    <dbReference type="KEGG" id="cthr:CTHT_0019520"/>
    <dbReference type="eggNOG" id="KOG3378">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_12_0_1"/>
    <dbReference type="OMA" id="ADIHYEV"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008941">
        <property type="term" value="F:nitric oxide dioxygenase NAD(P)H activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071500">
        <property type="term" value="P:cellular response to nitrosative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046210">
        <property type="term" value="P:nitric oxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08922">
        <property type="entry name" value="FHb-globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06184">
        <property type="entry name" value="flavohem_like_fad_nad_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.490.10:FF:000003">
        <property type="entry name" value="Flavohemoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000034">
        <property type="entry name" value="Flavohemoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000010">
        <property type="entry name" value="Flavohemoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009805">
        <property type="entry name" value="PRK13289.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396:SF3">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0216">Detoxification</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Globin" evidence="17">
        <location>
            <begin position="4"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="18">
        <location>
            <begin position="153"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00056398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGS22419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="421" mass="46515" checksum="4FBF2322735B1674" modified="2011-10-19" version="1">MAAPLTQSQIDLVKSTAPVLKEYGVTITTKFYENMLREVPELNNIFSTTSQRTGRQPRALANAVLAYATYVDDLDKLKHAVERIAHKHVSLQVTAEQYDIVGKYLIQAIGQVLGAAATPEIVDAWVAAYGVLAKIFIKVEGDLYKQNKADKWLGWRKFRIVRKERESDSITSFYLAPSDGALPLPRFQPGQYVSLQVDVPELGYLQSRQYSLSEGYSPESGYYRISVKKEEGTEAGIPGIISNKLHEKYNVGDEVELSHPQGEFFLDPTDASKAGVPVVLISAGVGATPLKAILDSLTGPSAVVKRPISWIHASRSRAVQPFGDAVREITKANDNVNSVVFLKNVGPEDQEGVHYQFAGTRLSLEKLDAEKDLFVNNPQAEYYICGPESFMIDVRRGLVGMGVDKNRVFLELFSTGDVPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3M7</accession>
    <name>G0S3M7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyltransferase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0021810</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692650.1">
        <property type="nucleotide sequence ID" value="XM_006692587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3M7"/>
    <dbReference type="STRING" id="759272.G0S3M7"/>
    <dbReference type="GeneID" id="18256219"/>
    <dbReference type="KEGG" id="cthr:CTHT_0021810"/>
    <dbReference type="eggNOG" id="ENOG502QVJG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005679_4_0_1"/>
    <dbReference type="OMA" id="DSHWFRR"/>
    <dbReference type="OrthoDB" id="5405781at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF128">
        <property type="entry name" value="ACYLTRANSFERASE 3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="3">
        <location>
            <begin position="10"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS20354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="476" mass="53504" checksum="CF8CF73146A31FCF" modified="2011-10-19" version="1">MAARPSQRNIKWVEGLRGVTSALVIVTHIARALDFPLFWPADSKGAAPRLLQLPYLRIPYQGRIGVPIFAFLTGFVCAYKPLKLAYQQGNQSAALKSVARSAFRRPPRLVLPALIATFISFIFSVFGGYKSANRCDSFWVRFDAPDDIPFGDNVKRLFRSSLTTWTNTENVYDRHQWAMRPLLVGAFQVYIVLAATIGMRFRYRVAVHILLILYWLSNRNALTETFGAMLAHGTLLAELAQHRPTQNFISQHQRLFTWVVAPLLLLIGGFVGSYPHEHEDWAGWSMWLHRLIVDPNGDGSRGSLLVPKGTQPGRRTSSFFIMCIALALSVSPALQKFLSHRLLIWLGHHSFAVYLVHGTILRTIGIWIVYGISGEPWEPAGKNADGSPREPKWLHPKSRTHKMVAIIVFTTLTYIAAWAWMKWVDSACARATQWLENKVFDDEDGEGKAGYAEKGYAPLNNGNGTAQPGERREPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3V8</accession>
    <name>G0S3V8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0039050</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS22020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694316.1">
        <property type="nucleotide sequence ID" value="XM_006694253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3V8"/>
    <dbReference type="STRING" id="759272.G0S3V8"/>
    <dbReference type="GeneID" id="18257943"/>
    <dbReference type="KEGG" id="cthr:CTHT_0039050"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_4_1"/>
    <dbReference type="OMA" id="CGSAITY"/>
    <dbReference type="OrthoDB" id="449487at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000481">
        <property type="entry name" value="Alcohol dehydrogenase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF3">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G13270)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="12"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="367" mass="39220" checksum="A74F58A1D6D961F6" modified="2011-10-19" version="1">MPRYLTIKKIDGKPGQVYYPLQLNTLPSHPTPGPNQLLLRVHAAALNHRDLFIRQHLYPGISFSSPLLSDGVATVVALGPGCSPATQSLLNTRVLILPCRGWEKDEAAPEGEFVIHGASRGSDVGTGAEYVVVNEGEVAPCPGHLSDAEAAALPLVGLTGWRALVTKGGLGGVEGAKGKNVLVTGIGGGVALQVLGFAVAMGANVWVTSGEEGKIQRAVELGAKGGVNYKEKDWDKKLKGMLPKDRPYLDVVVDGAGGDVVARSVKLLKQGGVIACYGMTVGPKMDWLMQATLRHIELRGCTMGSRREFEEMVKFVREKKIRPVVSRVVKGLDNLEGIESLFEDMKAGRQFGKLVILIEGEDKTAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0S408</accession>
    <name>G0S408_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CTHT_0022130</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692680.1">
        <property type="nucleotide sequence ID" value="XM_006692617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S408"/>
    <dbReference type="SMR" id="G0S408"/>
    <dbReference type="STRING" id="759272.G0S408"/>
    <dbReference type="GeneID" id="18256251"/>
    <dbReference type="KEGG" id="cthr:CTHT_0022130"/>
    <dbReference type="eggNOG" id="ENOG502QRTW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031730_0_1_1"/>
    <dbReference type="OMA" id="YGSQCAR"/>
    <dbReference type="OrthoDB" id="3238762at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF9">
        <property type="entry name" value="ENDOGLUCANASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409291" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="16">
        <location>
            <begin position="20"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="17">
        <location>
            <begin position="285"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGS20384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="322" mass="33180" checksum="76B16FD6B4DA657F" modified="2011-10-19" version="1">MKTLSLAALAALWAQKAAAHAMFQQLWVDGVDYGTQCARVPGSNSPVTNVNSPEIRCNAYPSPAKGKCPVKAGSIVTIEMHAQPGDRDCSKEAMGGAHHGPVLVYMTKVSDAATADGSTGWFKIFEDGWAKNPSGKVGDDDFWGTKDLNTCCGKMDVKIPEDIPSGDYLLRAEAIALHVGGQPGGAQLYMTCYQLTVEGGGNANPATVKFPGAYSATDPGILVNIHSAMNNYVVPGPPVYSGGTTKRAGSGCTGCEQTCKVGSSPSGTVSAIPVGTGAPNGGGGCYAQKYQQCGGQGYTGCTQCVPGSTCQAISPPYYSQCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0S414</accession>
    <name>G0S414_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0022190</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692686.1">
        <property type="nucleotide sequence ID" value="XM_006692623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S414"/>
    <dbReference type="GeneID" id="18256257"/>
    <dbReference type="KEGG" id="cthr:CTHT_0022190"/>
    <dbReference type="eggNOG" id="ENOG502SQ4R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_270324_0_0_1"/>
    <dbReference type="OMA" id="FGDQWAS"/>
    <dbReference type="OrthoDB" id="2426273at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596:SF2">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G17550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="944"/>
            <end position="964"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1001" mass="111670" checksum="AAE0FD2656C4C247" modified="2011-10-19" version="1">MDFLPHPSSGVGPLDIPFVADAPYQFGSYFWDFPKVHGFGDQWASLPAPRLAALVQSWLYFGTISEFLGRPIDYEQFHDNSDECTVTAKPLIPLLNEWVAAHVAEVASRAAVDGEAAGYQRWRMVLFQHARFLESVLRFAEDFDKVSQSHIKPIPSIILSVKVLCTALRGLLYDLADYDADDYSKPWPSPTDRMRREFLPATDTQGKPNYSPSTQVLLEAMFLRGWCPYLARKVLTSFNYANAYYFTRLYRVFSKEVNHDNCTDGECIATNADLFEYVPRHVHFGCICQPKVAPMDQIRAIIEAGGIPLIRLRPTKTGVRIEVVRMTARTRFVVVSHVWSAGIGNKYANALPECQLRRLYAHLSNLKPLSRHGARDSDFNLLNSLDMGFQTATPRRPKYLWIDVLCMPPKEGPTAFLRIQAINKLPAVYQAADRILVLDSKLETLSVHESDILEQFSRFAVSPWFGRCWTFQEAALASACEVQGADGTFDAFFPQIPKALTSGPLPPRRRQTPLLTALTHPIGQIKILLSRKSSGAGSFQPLDGRAPIIDFDANTALMASMTRSLNQEFRSAFSNGIKPEKTVFGEGALAPDFCTLFVQVWNELSKRSTSMPGDMPIIMANLLGFNSEPIMRLPKSSDRMACILRSMDGIPVSLLFNLFGLRHEPGRNHRDRWLPVYPSRDRLAFGSTFTNLRVVGDDMYMPNNCVSRKKVAVLVCTGPPDPFSSSTFTVRDVSTGERYAIELHRSEGDEFATPEIGPYIIAIQLDPELNARPEGLFIEGLDAIPRVYAGALFRVRRVVTRVKKVYNHNLDEGYDDSFELVEDEEGNALSDEISSKRSTDYLSGDISAAFGRYECGLLRTIYDCPMTVTRLPGGGAGDPLSSVCSTPLERPGPILTAQPLPPTWQIVIEREPAAYPYPLSTRPSLADAITPITAILTITAIDGLVASGSVGLAIAICATLFYTLNSLAKACLITKLVLHSLFLIQLFVYPGVERVRRRWMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0S415</accession>
    <name>G0S415_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DMAP1-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0022200</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692687.1">
        <property type="nucleotide sequence ID" value="XM_006692624.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S415"/>
    <dbReference type="GeneID" id="18256258"/>
    <dbReference type="KEGG" id="cthr:CTHT_0022200"/>
    <dbReference type="eggNOG" id="KOG3628">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000737_0_0_1"/>
    <dbReference type="OMA" id="LVWTYWT"/>
    <dbReference type="OrthoDB" id="69964at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010506">
        <property type="entry name" value="DMAP1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056881">
        <property type="entry name" value="Mug62_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754:SF32">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2 DIP2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23024">
        <property type="entry name" value="AMP-dom_DIP2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06464">
        <property type="entry name" value="DMAP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24919">
        <property type="entry name" value="Mug62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01137">
        <property type="entry name" value="DMAP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51912">
        <property type="entry name" value="DMAP1_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DMAP1-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="654"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1574"/>
            <end position="1639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1679"/>
            <end position="1781"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="657"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="678"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1591"/>
            <end position="1602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1682"/>
            <end position="1704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1737"/>
            <end position="1770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS20391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1799" mass="199071" checksum="3B263FCA3589A6EC" modified="2011-10-19" version="1">MAELNPELREKLDELEKELEEGDITQKGYQKRRTQLLSQYGLTDAALQQKLGELRIHNPDEPSSAPNQDPRATSLAALNANQPPADARPVSISSSIDYRPQSLYVANPDQHPANLLAPGGHAAEERPNLRQHSSLFLETGPFQEDQGRTATMASQNYAFNPDQHVAYGEPTPTQHYDSRHGTLLDSQGYFSDFAGQQQGYDSGAPGEYGGPHRYSSGEAFSPTAAMAPPMINTSELPPPPDALQYQMPLEPRDIPFAIHDPHDANTPMSTFDNIAAVLRHRGRTNEKSPAYWVLDNKGKEIASITWDKLASRAEKVAQVIRDKSSLYRGDRVALVYRDSEIIDFAIALFGCFIAGVVAVPVNEFQDYAKLNFILTTTQAHLALTTDNNLKTFQRDITAQKLNWPKGVEWWKTNEFGSYHPKKKEDMPPLAPPDLAYIEFSRAPTGDLRGVVLSHRTIMHQMACLSAIISSAPGNGPPDTFSKTLRDKNGQLIRNSPGSETFLSYLDARQGIGMILGVLLTVYGGHTTVWVENTVVETPGLYAHLITKYKPTILVADYPGLKWTAYNYQTDPMATRNFKKGMEPSFSSVKLCLIDTLTVDCEFNELLADRWFRPLRNARPREVIAPMLCLPEHGGMVISVRDWLGGEERMGCLLKLNRPSEENKEDEKEKEKHKKEKTASTGPSTLLGQGTTATTEEPTKNDLGEVLLDREALKQNEVMVVAIGDEVNKRANDPSTIRVGAFGYPIPDATLAVVDPETCLLSSPNTIGEIWVDSPSLSGGFWVLPKHTEQIFHARPYKFEPGNPTPTPVEPEFLRTGLLGTVIEGKVYVLGLYEDRIRQKVEWVENGTENAEYRYYFVQHLVVSIMRNVPKIFDCSAFDVFVNDEHLPVVVLESPAASTAPVTNGGPPRQLDTALLDSLAERCMDVLMQEHNLRVYCVMITAPNALPRVLKNGRREIGNMLCRREFDLGNLQCVHVKFAVEHAVLNLPVGIDPVGGIWSPLASNSRTELLAGADKQYSGIDRREVVIDDRTSTPLNNFTSITDLIQWRVARQPDELSYCTIDGRGKEGKGVTWKKLDLKIAAVAVYLKNKAKLRAGDHVVLMYTHSEEFVFAVHACISLGLVVIPVAPMDSNRLHEDVPAFLHLIADYKVKAILVNQDVDHLLKQKPIAQHIKQTAQVLKVQLPNMYNTSKPPKQNAGCRDNNITMDPAWTQPGYPVVIWTYWTPDQRRIAVQLGHDTILGMCKVQKETCQMTSSRPVLGCVRSTTGLGFIHTCLMGIYIGTPTYLLSPVEFAQNPASLFLILSRYKIKDTYATPQMLDHAMNMMPGKGFTLHELKNMMITADGRPRVDVFQKVRMHFAATGLDRTAINTVYSHVLNPMIASRSYMCIEPIELWLDPKALRRGLVYLTDPERDPKALLVQDSGMVPVSTQIAIVNPESRMLCSEGEYGEIWVDSEACVKAFYGSKDPFDVERFEGRTVEDPSISAVFQAGGLVVVLVEVARKAYLASLVPVIVNAILNEHQIVVDIVAFVSRGDFPRSRLGEKQRGKILAGWVTRKLRTIAQFAIKDMDRDILGSSHSHHATGSVSVGHPPGTSSGDQSSSTHGMGGGADSDHHHRSSLTSFRSSSAGVPHGQSSSLRNVEHAPQIPEHRELDFQFDFPPSSGPVEMPADDRVPTLPQISEVSTTTNTNNQTSSGSGNGDDMGSSPTLPTNAYELPDEQNRRRISLSSSSPQPPPPMESSADQGQGQGYQEQQRPASSQPQQQLPPQIRLPGVDGRESLSEDWLKDTYASMNLAGTLSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4E2</accession>
    <name>G0S4E2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Small ribosomal subunit protein uS10m</fullName>
            <ecNumber evidence="4">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">37S ribosomal protein S10, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Mitochondrial ribosomal small subunit protein 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CTHT_0022500</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="4"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692716.1">
        <property type="nucleotide sequence ID" value="XM_006692653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4E2"/>
    <dbReference type="STRING" id="759272.G0S4E2"/>
    <dbReference type="GeneID" id="18256288"/>
    <dbReference type="KEGG" id="cthr:CTHT_0022500"/>
    <dbReference type="eggNOG" id="KOG2713">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3321">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008277_2_0_1"/>
    <dbReference type="OrthoDB" id="15808at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070183">
        <property type="term" value="P:mitochondrial tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000003">
        <property type="entry name" value="30S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000002">
        <property type="entry name" value="Tryptophan--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050203">
        <property type="entry name" value="Trp-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="17">
        <location>
            <begin position="167"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="110"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="344"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00035261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00078476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGS20420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="711" mass="79582" checksum="56EC12976A69C408" modified="2011-10-19" version="1">MANPRAKISAEGFDDKPFTQHPRLSRGKQDECAAVNKAIGALFPRAIAPRGIPVVGDAHCSGFDTAPCHGCHAQLSCHNKGDEVSQPRRRPLNHEVLRKPSKCLPVTYSSVASPPPSAVATNEPPKTPAGQKKGEEDEGIDRMPRSIEAFWLKPLRREVEYGVPMCDLQLRSYSARNLEFFCDFALRAAYYLGLPAFGPVPLPRKIQRWTVPRSVFVHKKSQENFERITLRRLIQIRDGHPETVQLWLAFLQKHAYYGVGMKANVWEFSKLDVAKEMDAAVQETEKLLEDKWEHLGYLQRKPEFSPKGKEVVEKLPKPEEIEEFLATERRKVSAGSRSAGIEVQGKESRGAVKTKDKSEKPERKVVFSAIQPTGIPHLGNYLGALSQWKRLQDEAIKDPNIKLYFSVVDLHALTVPGPKEALVASKKQTLAALLAIGLDPEHCALFYQSRIKQIANLYWILGCTSSMGYLSRMTQWKSKLKLDADTSLEDSRAKAALKHGLFSYPILQAADILIHRATHVPVGDDQRQHLEFARECVTNFNSTWKTNCLVAPETVIAPTKRIMSLTNPREKMSKSDPKARSRIHITDAPEEIEKKIKGAVTDALGNITYDPVERPGIANLLDILSAFDKQGRTPAQLAEEFADQQAPDLKAAVTKALIDGLAEIRDRYQFFQENEKALKDAEETGTIRAIRSAGNTMSMVEKAVGIYDFFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4P3</accession>
    <name>G0S4P3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tetratricopeptide repeat protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0023040</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692768.1">
        <property type="nucleotide sequence ID" value="XM_006692705.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S4P3"/>
    <dbReference type="GeneID" id="18256342"/>
    <dbReference type="KEGG" id="cthr:CTHT_0023040"/>
    <dbReference type="eggNOG" id="KOG2002">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003008_0_1_1"/>
    <dbReference type="OMA" id="EHWLTIA"/>
    <dbReference type="OrthoDB" id="343875at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031101">
        <property type="entry name" value="Ctr9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027:SF2">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="604"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="800"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="973"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1013"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="977"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1013"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1062"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1113"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1133"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1152"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1207"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1244"/>
            <end position="1253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS20472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1289" mass="145332" checksum="F1213F002B54171D" modified="2011-10-19" version="1">MASSQTLSGANGVPNGAIAAPKSKRFSDIPQTIDIPVQDQDDEAVEIDLEELADDPTELCTLFEMEHAARTYWMTVALAYAKQKKIDFAIEMLMRGANALQANPREKLSIITCLCWLYLYKSREAPRVAPDNVPASEVKTKEHYLQLATQSLNEASRINPAFPPLFLARGVLLLLRASLQPPSKGVGPTGVDSQKAEQLCNALKSFEEAIRVSQGKNMLAVMGKARALFSLGRYPESLAAYQEVLSKMPDMVDPDPRIGIGCCFWQLGYKDDARQAWERCLEINPESKTANILLGLYYLDASGHVPTNSPEFIRLYKKAMTEFTQKSFKLDKNSPLACSTFAGYFLSRKQFDTVDSLAHKAIRYTDVNAVASDGWYLLARKEHYAGNLERAADCYRRADDARGGAERGYLPAKFGLAQLSVLKGDLGEAKLRLEKIIQQSKNYEAMVLLGTLYAEEVFANQSAAVKEDKSAEAKKAIALLEGVRSAWKDPKKNLSPDACVLLNLARLYESEQPDKALQCLQQVEQLELSQIPRSEYPPDTEDEAVIKAAIRKLLPPQLLNNIGCFYSQEGKHTLATEFFQAALDSCARISSQSDSDIDTDALLTTISFNLGRSYEYEGQIDAAVETYERLLSRHSDYTDARTRLAYIKLRRNPSNKEGPDAVAKLYQENPQDLEVRALYGWFLGRVNAKKRPANLAEDPEQRHFKHTLQNYDKHDRYALVAMGNLHLMAAREMRRETDQDRQKRSATYSRAVEFFDKALQLDPKNAYAAQGIAIALIEDKKDYTNALQIFIKVRETIQDAHVYVNLGHLYAELKQFTKAIESYEIALSKEGKARDANILSCLGRTWLNKGRAERNLDAYKTALEYAENTLSVAPEQLHFKFNVAFVQIQIAMLLISFRDSERNSFQLEQASEGLEAAIKTLDEIAAAPNPPYPKHDLEQRANMARNTMRKQLERALASQREYEARNKEKLQAAMEARQAELRRREEERRRAEEAERERQEKIRREREEILARDRALAEQRAEEERLRMEAEMTTDTETGEKVMRKSKKRSARARSGEPSRSGRARRRKSTAHRGESGEDGANAGDEGAERRRARKRQRLTKKDSKYKSAEIVVDSDESDDGGAGIDEEDPLEQAERRLAEAAAERKRERRAAQSGSSRSRSNSVASNRSSRSARSTRSRSSIFGSNDDDEEDRPAKRQIRRRRSSAEEEEEEEDDKMDVDQEVSAVPAPVADNDDEEEETIARRPQKRAARRGRILDESDEEEEAAGNAPTPGAAEEKADTSMVDADED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4T3</accession>
    <name>G0S4T3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Mitochondrial DNA polymerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CTHT_0023440</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Involved in the replication of mitochondrial DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692808.1">
        <property type="nucleotide sequence ID" value="XM_006692745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4T3"/>
    <dbReference type="STRING" id="759272.G0S4T3"/>
    <dbReference type="GeneID" id="18256382"/>
    <dbReference type="KEGG" id="cthr:CTHT_0023440"/>
    <dbReference type="eggNOG" id="KOG3657">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001524_2_1_1"/>
    <dbReference type="OMA" id="AMHITNL"/>
    <dbReference type="OrthoDB" id="5588663at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005760">
        <property type="term" value="C:gamma DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08641">
        <property type="entry name" value="DNA_pol_gammaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000035">
        <property type="entry name" value="DNA polymerase gamma, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.390:FF:000003">
        <property type="entry name" value="DNA polymerase gamma, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.390:FF:000006">
        <property type="entry name" value="DNA polymerase gamma, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019760">
        <property type="entry name" value="DNA-dir_DNA_pol_A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002297">
        <property type="entry name" value="DNA-dir_DNA_pol_A_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041336">
        <property type="entry name" value="DNApol_Exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047580">
        <property type="entry name" value="POLG_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267:SF0">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18136">
        <property type="entry name" value="DNApol_Exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00867">
        <property type="entry name" value="DNAPOLG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00447">
        <property type="entry name" value="DNA_POLYMERASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family A palm" evidence="16">
        <location>
            <begin position="725"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="665"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00057053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGS20512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1194" mass="134899" checksum="56EF192EE8D98226" modified="2011-10-19" version="1">MLLSIRTHSLPGRGRGRDAPVAGFIRLRRHHHVVCSSSRHFPLLTSRRWQSTGAIASDNRGDDNRKSLALPCQPRFNEIGVQQLSDRIYQQLFPRGNTCPPSPKLIELARDHLQRHDLLGKNTDKNPPIAFDLPPLAGETLDEHFYKLGVDCAEPFLTLAKEFANKSLPPMPKSWVRQSGWTKYYPDGRTERVDAPEGQLLSFDTEVMWKESPFAVMACAATPEAWYAWLSPWLLKETDNDHQLVPLGDPTKERVIVGHNIGFDRARILEEYSLQQSRNCFLDTMSLHVAVNGMCSQQRPTWMKAKKNRELRDKIAKESNNLELVHLLNNGAFTAEEEELWVERSSINSLRDVAQFHLDITIEKELRDSFGELDRDGVLAKLDELLTYCAIDTDITHRVYKAVFPNFLSTCPHPVSFAALRHLASVILPVNKSWDAYIANAEATYHRLSDAVQERLIFLAEKALEIKDKPEVYQNDPWMKQLDWSGQEIKMVKGKRKGDPPRPAARQKKPGMPQWYKDLFATNDSPINITVRTRIAPLLLRLSWDGHPLFWSNAHGWTFRVPRGQSKKYEDKLMTPCEFPDEADKHLREDMDHVYFKLPHKDGPTARCVNPMAKGYLSYFEKGTLSSEYPYAKEALEMNASCSYWISARDRIMSQMVVYEDQLPPSMTTALPKPSQPQPSDEKHPNETSVCGFILPQVIPMGTITRRAVENTWLTASNAKKNRVGSELKAMVRAPPGYVFVGADVDSEELWIASVVGDATFRLHGGNAIGFMTLEGTKAAGTDLHSRTASILGITRNDAKVFNYGRIYGAGLKFAAQLLRQFNPSLSEQETMDIASKLYASTKGTKTNRKVLYKRPFWRGGTESFVFNKLEEFAEQERPRTPVLGAGITEALLGRFIRKGGYLTSRINWAIQSSGVDYLHLLIVAMDYLIRRFNLAARLAITVHDEIRYLVQEHDKYRAAMALQVANLWTRCMFAQQVGIHDLPQSCAFFSSVDIDHVLRKEVDMDCVTPSNPNPIPPGESIDIHTLLDKGDLARLDENIEPDPKYAPKLDGIHYVPRKPVMEELREAECGGDPEAEIRFIRAQICNDEDELREILRDARKATPLAGVFNVKAAGGGTSSSSNISSIGTSMLRKPFTPYSTGKVPGLPPQREPVFVTEAWNSSRFDKWKYGSNARPPKPIAPVNTKLGDMCFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4U8</accession>
    <name>G0S4U8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0031740</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693615.1">
        <property type="nucleotide sequence ID" value="XM_006693552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4U8"/>
    <dbReference type="GeneID" id="18257212"/>
    <dbReference type="KEGG" id="cthr:CTHT_0031740"/>
    <dbReference type="eggNOG" id="ENOG502QZ1C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_304025_0_0_1"/>
    <dbReference type="OrthoDB" id="5245577at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="333"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="420"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="532"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="644"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="697"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="37"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="250"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="281"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="349"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="448"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="471"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="536"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="715"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="742"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="771"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="821"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="861"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="929"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS21319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="978" mass="108264" checksum="E88A25E40D617366" modified="2011-10-19" version="1">MTSLPDICGLVSQMQEILTQIHSTITSLDTAFHDAKLDELEKQRGDALQQLSAAFNAETQALQMKRRAEREAVAERRILEDEERERKRKEEDQQLALRDLEEDDAREAKLKSEAQRIEQETGELMMRVEEEARAAVTEGRQRLEALQEKRRELNRLIEEHLEKSLPTLPITPLRSRRALQTDTASLLRFRQPDSVKPDGVTGASQYSHIRPDGKRASSPSQPGLWKPSRLSSSFGPTGSHNDSIPKGMWTSKQSSFTGNKLSEQESDYRPSIDSAGTTGIPQSEEPSPSIESPASKEAVILDMHRFHEESKNSEPPAGNSRKTSDFFTPQAAIRSETSRETILADVTLGSDSSTTSGQVPSDSDRSLQGIDLVPNQSATRISLEYGDTIPEITNGHSLPVSRLKGEHGFFAVNQEDISSSSWHVSTEVVSEPEITDASTKAKEGSPEPASQQIETSSEGLYESVTSPAPPDDERSESRAHLTSDGPNDNNGHHDEPVPYDEIAPSNQVLSQSLRDANSAAYYTPGDFPLPSTNCSKDIDGQMSQDHRADKDYTGEEDVKLAVNEGLDRVLAGSEAGPSILAESSLHLPQVSGEIALQLSPKETRSNELDVVNENDNPELPAEWKEDSGARNLSPGVDIHMLGKETQNRSAGKSVVAVESDNLSPRTGDVDPTTNPDDAENRVESLITMLETLRKFREPSINRQLMNSEAPAGDDEQSHRTDKLEGPDPLPEPHTEPSLNPRSKNEGKRKSQDSEYDPFRPERYRMPRFARSGSSSDNDSQRFVTPLTSQTFPRKPQAGPSNYFVTTHSEEPQAEQATSEIDELRDQHTVTNHGEDFLFDDDERSEDNASPQSRIDIDPSDPSAQKPTSSDRLQKTQGIDDAYLESPESSANAMSENGWEEEVTNYYGEDAKEVRSPPVQQNTGHHEQSGLEQPCQQQTANPGRTLEAPRKPRHRHLLLKSMSPFITKGLSFTIREVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0S544</accession>
    <name>G0S544_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycoside hydrolase family 30 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0024030</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692865.1">
        <property type="nucleotide sequence ID" value="XM_006692802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S544"/>
    <dbReference type="GeneID" id="18256441"/>
    <dbReference type="KEGG" id="cthr:CTHT_0024030"/>
    <dbReference type="eggNOG" id="KOG2566">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1255847_0_0_1"/>
    <dbReference type="OrthoDB" id="2012278at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006680">
        <property type="term" value="P:glucosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069:SF23">
        <property type="entry name" value="LYSOSOMAL ACID GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS20569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="24320" checksum="222248197692FACC" modified="2011-10-19" version="1">MYRSHLSLYLTRTCQRIDGFGFSLACQRANLITNLSDKTKQRELLDLLFNRTTGAGFPILRNGIGSTPNSNSDYMNTIAPDNPGGPNAQPQPMPTASRLAAYIKLYMQEGMNITHLGFLNEPDYSANYARMQANGQQAVDFFKIPHTTFEREGLTSQVGITCCNSMGRQNQVNMHNAIRSGGAEQYLRAVTSHLYTDSPFAPMTANPPVWLSGQCDLQGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5C4</accession>
    <name>G0S5C4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0024310</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the GSE complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692893.1">
        <property type="nucleotide sequence ID" value="XM_006692830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5C4"/>
    <dbReference type="STRING" id="759272.G0S5C4"/>
    <dbReference type="GeneID" id="18256469"/>
    <dbReference type="KEGG" id="cthr:CTHT_0024310"/>
    <dbReference type="eggNOG" id="KOG3887">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047421_2_0_1"/>
    <dbReference type="OMA" id="NCRTFQE"/>
    <dbReference type="OrthoDB" id="26136at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11385">
        <property type="entry name" value="RagC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.190:FF:000005">
        <property type="entry name" value="Gtr1 g domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000643">
        <property type="entry name" value="Small monomeric GTPase (Gtr2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039400">
        <property type="entry name" value="RagC/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF2">
        <property type="entry name" value="GH16429P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS20597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="419" mass="47183" checksum="950C00AB3F336886" modified="2011-10-19" version="1">MSTPVEGSGPVNLDAGALRSRLAKYQSPAALKLYRVYEQNRQRLSKDDGAIAVKVPDSTATVPQPRGKPRLLLMGQRSVVFHKLPPSETLFLESTARIQKDSLNSFMEFQVWDFPGQIDIFDNPNFAFDMDAIFGEIGALIWVIDAQDDYLEAVRRLNTTILHLQRSYPHINIEVFIHKVDGLSDDYRLDIQRDITIRIQDELSDQGIENAPVNFHLTSIYNHSIFEAFSKVIQKLIPRLGQLEAMLTNLCRTCRFEKAYLFDVNTKIYIATDSTGPEDMASYEICSDFVDVIIDFTEVYGSWPRSREWRARLEGAPWHQPLEQQVACEWAESGMVLADARRPIMLREVDRFLALVAIMKEGSYEKMPQINMNVDVVVKGLTEFFEITKQKEVTGAGVGTGAVQAAQGGTVGPVGVQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5K5</accession>
    <name>G0S5K5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DUF221 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0033280</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693766.1">
        <property type="nucleotide sequence ID" value="XM_006693703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5K5"/>
    <dbReference type="GeneID" id="18257366"/>
    <dbReference type="KEGG" id="cthr:CTHT_0033280"/>
    <dbReference type="eggNOG" id="KOG1134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002458_2_0_1"/>
    <dbReference type="OMA" id="FVQFNHQ"/>
    <dbReference type="OrthoDB" id="1076608at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF20">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="714"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="765"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="807"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="856"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="930"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="968"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1002"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="11">
        <location>
            <begin position="36"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="230"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="620"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="712"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="10">
        <location>
            <begin position="1172"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="312"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="425"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS21470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1251" mass="140805" checksum="1E2C854BFFF6B903" modified="2011-10-19" version="1">MSQPTPTSAHAAASPSSAIPEGPGSAQESTGISLIAFISALAASLIVFGVQMSLFFFLRNKLVRIFKPKTYLVPERERTDPPPSSHWALAFKLMSFEDREIIKKCGLDAYFFLRYLQTLLIIFIPIALVVIPILIPLNYIGGLGRDVVNGTIDGGVTDGTVTISVPTGLDTLAWGNVAPNKQDRRWAHLILALLVILWVCGVFFAELKVYIKIRQDYLTSAEHRLRASANTVLVSSIPDKWLSETALRGLFDVFPGGIRNVWITRDFTALLEKIHERARIHKQLEEAESELIRKAKRRQMKQAREGTLIQRMKAQNRADRAQRAKEEDEAAQRRAEGEGGLSAHTPHLPHGIQEAVAEAEGDKFDPKINHGRPGSPFGKIGRGIGKGVGKGVAVVAGAGMGLVEGATAAIRRGIDEELERKAGFGFVKTDDPRRPASPITPDSGSAHGGDTDDDYRPKVSFASEAPLKYSSSPSGSSQEAQDDSKAKNRQSARQSYLRHYGNTTRRATNLDEMIVTKKTRWWEFWKPPTGSYASPIPQGYEEREQDWKDDHKSFWDILRNSVPLLRDPGPAVEYPPAYTRDYTTQPEEDAEWRKWLKPEERPRHRVPRWPGLPWWLPLIFPPIGKKVDTIYWCRQELARLNLEIEEDQRHPERYPVMNSAFIQFNHQVAAHMACQSVTHHIPKQMAPRMVEISPDDVIWDNMAITWWNEWARRAVVFLLVTAMVVLWAFPVAWTASLSQIDALIRKYDWLSFLVENETLHNAVKAIAGVLPALVLSLILALVPIVLGYLATWQGAKTGASKSETVQVYYFSFLFVQVFLVVSIASGTFQTIAHLTSNLQDTPQVLAENLPKAANYFFAYMILQALSTSSGTLLQIGTLFIWYIWARIVDNTARAKWTRNTQLPTVTWGSFFPVYTNFACIALIYSIVAPLISLFAIITFSLLWVAHRYNMLYVTRFKTDTGGILYPRAINQTFTGLYVMELCMIGLFFLAQDETGVNVCVPHAIIMIIAFFLTALYQYVLNSSFGPLLRYLPITFEDEAVLRDEAFRRAQARRLGLITEDDEATDLTNPAGDHSADDIELEKLGDKTNDTHGKGHRRTASTFDRFRHQAGTWAARSGKQVMRAATFGGRAEDALRQAAQYRRERRQKDLEAQRAMGEALFGGYCDGVEDLTPHERDALVRKAFQHSAMRARRPVVWIPRDDIGVSDDEIRRTKEFSEYISITNEGTALDSRARVLYGRNPPDFSEVDLINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5M3</accession>
    <name>G0S5M3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0024780</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692938.1">
        <property type="nucleotide sequence ID" value="XM_006692875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5M3"/>
    <dbReference type="GeneID" id="18256516"/>
    <dbReference type="KEGG" id="cthr:CTHT_0024780"/>
    <dbReference type="eggNOG" id="ENOG502SQ20">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037033_0_0_1"/>
    <dbReference type="OMA" id="KARRFWW"/>
    <dbReference type="OrthoDB" id="2126185at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS20642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="532" mass="58434" checksum="2E7957C73F51B0D8" modified="2011-10-19" version="1">MAPVETDHGGGSLSIMLTASRPAIAAYLSYIVGKTRFRGVEDANSTFVHLGPWLRDTSVAFDALEILAEKTRRLWWGQQLDSAIVAWITLLAIEGHRRYIPHLWAYALLAHLVGLSYAQNLFYMAMLLAPWPFSPLETRLSKTFHQFFPRKHDNWFPKLAPVLGSLALSYGAIGWLSYAANTSWFAMAAVLSKLMTLSPLILTTVAPSSWGTTHPSSRDIHRETTKVFNMIALASSILHAKTSLCSFLYNLPDAYRHRHSMYIPYDTERRSRWERTATAIEKVLGSMADHPVVAAAGKDVLLSGLSLGLWAAVRALDVGCMLRSVLPWSKYHLHTEETKSGPEAPSYAQVAAAASAAAKKAATDRTIHAELRKSSTQGYGHAHHEVPPLTMNLRQRRQSSLSSETFIGHTHKPVSPTKKRGPGRPRKINPNPDSKPPSPPDTEPSEPSPTKPSLSLMEGEEEKQQLESELREWHEHPTTQLPKNRIGSAAKLAGEEEGQPDWESAALAWGMTVLGGLGVGSAGVFGGEGVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5S0</accession>
    <name>G0S5S0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein Urb1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0033400</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693778.1">
        <property type="nucleotide sequence ID" value="XM_006693715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5S0"/>
    <dbReference type="STRING" id="759272.G0S5S0"/>
    <dbReference type="GeneID" id="18257378"/>
    <dbReference type="KEGG" id="cthr:CTHT_0033400"/>
    <dbReference type="eggNOG" id="KOG1791">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009575_0_0_1"/>
    <dbReference type="OMA" id="RYITFKR"/>
    <dbReference type="OrthoDB" id="72892at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059018">
        <property type="entry name" value="HEAT_URB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039844">
        <property type="entry name" value="URB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032436">
        <property type="entry name" value="URB1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021714">
        <property type="entry name" value="URB1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500:SF0">
        <property type="entry name" value="NUCLEOLAR PRE-RIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500">
        <property type="entry name" value="NUCLEOLAR PRERIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26140">
        <property type="entry name" value="HEAT_URB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16201">
        <property type="entry name" value="NopRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11707">
        <property type="entry name" value="Npa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="URB1 N-terminal" evidence="1">
        <location>
            <begin position="96"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="URB1 central HEAT repeat" evidence="3">
        <location>
            <begin position="630"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="domain" description="URB1 C-terminal" evidence="2">
        <location>
            <begin position="904"/>
            <end position="1101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS21482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1146" mass="128178" checksum="5DA3F8419E9C32E0" modified="2011-10-19" version="1">MGKRLARALDGPAVPRKRLKVVHEAPTSEEVKTSKQLQHLLSFTPDTARARHGLQSFKLFLDELLHPEHDPERLSLLEAYLEAVKPNADDENPVFLPDIMQLWSHAAQTNNENIMSAVPVVLDLLLRLLSKTLDTVPYGLGICRTLLQKRQQELIARNLSADKSKSFIISPTLRVLREAIAFDGGTIARPLFRARANMLKSLARNMGIVHIGDEPEDAKRPSTRTNAVLFFLSALRFLHAEAKKELLSQRDIVSALTRDIKQDPPYLVKDILDGLKVHVLLDDKLPREAKSALLNASTLTRLSTLYQYRLDSPGEDEISIADIAHEFLMLACTNPSCGVLRQDSGYYPREVDLNVTIPDADIDDLGLEAIVWMNKFKAEVPVRNYTLSNFLPNLRPWSSVKQSELITAIFKVAPELVANYFLNNKSFSFEPKLSATWIGYAAFLFNIVTLPIPAHFCRGSDFATLPPPTSIVIDNILPPPLNQKALTRCLNHKSNLISFFGVRILVVAIEKLDQAIKLYHESSHTNKTAWTEAAKRLVDEFCQRSPSIKDMINAYRSIPEANLMHREAASRLLRLCYEVLPQMALMAKFDVSPLLETCLRRLSSQELDDPRDFALSLKELENLLAIAGYSPGMRWLVASEGLSLSPFTMLLKVCLEAPHGVALEAIRQVLDFVAKEQQVVPASDHHPGLLVLLEALQALGAEKPESVVQVWPFLDNCLTRCANAPVKYVEKLQQIVLEGAKTLDTGLSEAVVSPLAIVMLEQLPFVAAKKDEQDKLRALGEFLPKFLGYSVTSGESKPVLDLIFCKMAEYLPDIKDRVEKPGVLGGLVFTYSDWSRHTKTSVCTQKSEKKPIASSEEGQGKETIDLETLEAMLDVTDALKADNSALTKWISKTVDELVDEGYLTALISLLVSEHASIRKEALVNILKAAAKIKQSEYEEKEQVWLLLSELAETARDKINDGPLPSTTVSFACHALNVLRDPLSHLYPKVNTFLIRGPSWNLDKPPLVTEILSEDPAIGDSWYAQSGWLLEYLLDGLRTPSDFELFHKKRLKGPLFERILTLAANPYLRAPLRMQLCRLIYRTTKIEGGSTTLITRLGIMSWLEAREADCLDPSEAVIYAGLRERIWDTCDQARVKSWSKSGLGHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G0S651</accession>
    <name>G0S651_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA mismatch repair protein pms1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0034200</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693855.1">
        <property type="nucleotide sequence ID" value="XM_006693792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S651"/>
    <dbReference type="STRING" id="759272.G0S651"/>
    <dbReference type="GeneID" id="18257458"/>
    <dbReference type="KEGG" id="cthr:CTHT_0034200"/>
    <dbReference type="eggNOG" id="KOG1978">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004131_0_0_1"/>
    <dbReference type="OMA" id="MRPRRMP"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03484">
        <property type="entry name" value="MutL_Trans_hPMS_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000014">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000120">
        <property type="entry name" value="Mismatch repair endonuclease PMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF52">
        <property type="entry name" value="MISMATCH REPAIR ENDONUCLEASE PMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="5">
        <location>
            <begin position="220"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="4">
        <location>
            <begin position="863"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="376"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="472"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="638"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="773"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="427"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="445"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="478"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="523"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="650"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="669"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="780"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS21559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1018" mass="111923" checksum="C20776969EB754A7" modified="2011-10-19" version="1">MASSATIKAIDSNTIHQIQSGQVIVDLCSVAKELVENSIDAGATAIEVRFKNQGLDSIEVQDNGSGIAPHNYETVALKHYTSKLSSYDDLETLQTFGFRGEALSSLCALSRLSIVTCTQEQAPRAARLEFEPSGKLKSTTVVSGQRGTTVIVEDLFRSLPVRRRELERNIKREWGKVINLLNQYACIQTGVKFTVTQQPTKGKRMVMFSTKGNSTTRENIINVFGVKTMNALVPMDLTLELIPTAGPLTKGKARTDRKSTEVRVVGHISRPTHGEGRSTPDRQMFYVNGRPCGLPQFAKVFNEVYRLYNSSQSPFIFADIQLDTHLYDVNVSPDKRTILLHDQGQMLDNLRESLIELFETQDVIIPMSRVAALKQTSSKISTARPSPSTSPQETGSKSAAADSRLSKATTSFRAMENTGDNANEESANTEDNVDDVEKEDTRPRQQPKMHFRHSKPQAQFKGFTTLSNWLRNELPRPSHTSSPLSEEQATEASTRDKGMSSSVTSAGDRGDRIPQSQVTGDTNVRDDERSLLPDVGKDDEIAPNEPESPIRALCPPSQPPTLRMSSTPSKPLKRATQEMATITIGDHTVRSAIGNPSKKPRVDEPAKPVVKTGVLKGGMRSTQLPSFGIRLSQLFSASTQPEGDLELIEDAGKGIEEHEVIEEKKGEEGREEDDGHDSSDDDADGLFVSQDGNKDAEDEGSGEGQPEEILKPMETDQPQSMSDADVPMESLGTHLASCDQEHGDNDFEYVDEEEKVARENQKVQAMIQEAEIATAESTEETEKRSETFVKGRPKRKDMTCNLVQRVKANCSEIRRRIEYLSSRLPQEACQTTAGVRLESIESEDAEAKLSLKISKSDFTKMRIVGQFNLGFILAVREAVSASSSTSCSRDSGTKDDDELFIIDQHASDEKYNFERLQATTTVQSQRLVQPKTLSLTALEEEIILANLPALERNGFSVSVDTSGASPVGSRIQLLTLPLSRETTFSIADLEELIFLLADNPTSNATTVPRPSKADGKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6A4</accession>
    <name>G0S6A4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0026050</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693064.1">
        <property type="nucleotide sequence ID" value="XM_006693001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6A4"/>
    <dbReference type="STRING" id="759272.G0S6A4"/>
    <dbReference type="GeneID" id="18256643"/>
    <dbReference type="KEGG" id="cthr:CTHT_0026050"/>
    <dbReference type="eggNOG" id="ENOG502R9MA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_973190_0_0_1"/>
    <dbReference type="OrthoDB" id="5418627at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="286" mass="31521" checksum="A509118D240F83B1" modified="2011-10-19" version="1">MKANGETEGRELTIKVGPQATVEPVDAEIDEQDAAANGILGSPIEEMAKFDDDGSDASDDEFLSIKPKRKSSLLLPGSSKSVVASSSKQPATPSSSTSKREHHRHHGNTEDDYDDPLFEVEDIEAERKEQKKYIQDDDDDHTPSLRLRTLAREEQIQREAGIPPEQLKMRNGTSGSQSWKPPPVSPSAVLFGHSIGSYKGRSVTINPIKDPQLYDEIAKLKDVHFWVGSVDGRSGIEPADMGSYRAANRNSIIGQGGVPMSFTQRLALEEEMERRRLAGEKLPDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6E5</accession>
    <name>G0S6E5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exocyst complex component EXO84</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Exocyst complex component exo84</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0034630</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Plays a role in both the assembly of the exocyst and the polarization of this complex to specific sites of the plasma membrane for exocytosis. Also involved in assembly of the spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the exocyst complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EXO84 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693896.1">
        <property type="nucleotide sequence ID" value="XM_006693833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6E5"/>
    <dbReference type="STRING" id="759272.G0S6E5"/>
    <dbReference type="GeneID" id="18257501"/>
    <dbReference type="KEGG" id="cthr:CTHT_0034630"/>
    <dbReference type="eggNOG" id="KOG2215">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012488_2_0_1"/>
    <dbReference type="OMA" id="AAWLPNR"/>
    <dbReference type="OrthoDB" id="642193at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000264">
        <property type="entry name" value="Potential exocyst complex component Exo84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1220">
        <property type="entry name" value="Exo84p, C-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1210">
        <property type="entry name" value="Exo84p, N-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033961">
        <property type="entry name" value="Exo84"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032403">
        <property type="entry name" value="Exo84_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042561">
        <property type="entry name" value="Exo84_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042560">
        <property type="entry name" value="Exo84_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426:SF12">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16528">
        <property type="entry name" value="Exo84_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25345">
        <property type="entry name" value="PH_EXO84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst component Exo84 C-terminal" evidence="14">
        <location>
            <begin position="457"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="150"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="391"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS21600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="687" mass="76123" checksum="F6398EA6F460A61C" modified="2011-10-19" version="1">MSEERSKISLRSGGKRKNRPLKISGPILQDDGSGRGPPGPSIADQAPIPRPRPPPQASAKTSDLVKRRYSTRFNADFDPSATAPPPVPSLPSIERYAQAQNQDRRAPPSRDGGEAGAAGAGGSGPGIPVDIKALRDPSLAADQYVANILSDATEDEIRDYEAALRNLKSRASADLQQSVYQNRTQFIKISKEAEKLKNEMRTLRNLMAELKANTTALRSASNSVGGHGFDGDIPMGLSKREKRSSVADRTALWSAQMQALYKTVEGSQKFLPNSPGRHVVQNAGLWVELDNATYRSRRAMQIFLLNDHILIASRKKRKVDAPNDSRAPMTKLVADRCWHLLDVEIVDMAGPSDSSSGRNKLADAIMIRGGGNESFIYRTEKPGDPEKASLLLNIRKQVEELRRTLQSEREATNKAKETINYFASRDPGLLQKTELLETLSDIKDMLIEVDGKQQNLRWVESQMDELDINIALQQIEPAVARIEKLRNLAQGLKHNVIAQDFISFKVDERRMKLAALLIRELVTTHNQKVKTKANVSWLTRLGFEDRAREAYLEARSEIIQKRSRQCIFQGSLEQYIWEIAFVYFTLIRNTVSCFQACFPAPMMSACVKWAKEEVDAFNSILSRQLSGEEEGSEIWTRCLDAALEHAGTLFDVGLDFTSLVGQNLRTGTGIVAASDGQTNAPVGLGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6E6</accession>
    <name>G0S6E6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0034640</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693897.1">
        <property type="nucleotide sequence ID" value="XM_006693834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6E6"/>
    <dbReference type="STRING" id="759272.G0S6E6"/>
    <dbReference type="GeneID" id="18257502"/>
    <dbReference type="KEGG" id="cthr:CTHT_0034640"/>
    <dbReference type="eggNOG" id="KOG0371">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_8_1_1"/>
    <dbReference type="OMA" id="EGYNWGQ"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000003">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="8">
        <location>
            <begin position="134"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS21601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="329" mass="37581" checksum="A16641BB6E0E15E4" modified="2011-10-19" version="1">MDTNMEDVHVGRIPPDLGPINVEPTSIPTLDGWIESLMQCKQLSESDVQRLCEKAREVLQEESNVQPVKCPVTVCGDIHGQFHDLMELFKIGGPNPDTNYLFMGDYVDRGYYSVETVTLLVCLKIRYPQRITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALIDNQIFCLHGGLSPSIDTLDNIRALDRVQEVPHEGPMCDLLWSDPDDRCGWGISPRGAGYTFGQDISEAFNHNNGLTLIARAHQLVMEGYNWSQDRNVVTIFSAPNYCYRCGNQAAIMEIDEHLKYTFLQFDPCPRAGEPMVSRRTPDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6T8</accession>
    <name>G0S6T8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative anaphase spindle elongation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0026840</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693142.1">
        <property type="nucleotide sequence ID" value="XM_006693079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6T8"/>
    <dbReference type="STRING" id="759272.G0S6T8"/>
    <dbReference type="GeneID" id="18256722"/>
    <dbReference type="KEGG" id="cthr:CTHT_0026840"/>
    <dbReference type="eggNOG" id="KOG4302">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013892_0_0_1"/>
    <dbReference type="OMA" id="QLHGIYD"/>
    <dbReference type="OrthoDB" id="642895at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007145">
        <property type="entry name" value="MAP65_Ase1_PRC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321:SF41">
        <property type="entry name" value="FASCETTO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321">
        <property type="entry name" value="PROTEIN REGULATOR OF CYTOKINESIS 1 PRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03999">
        <property type="entry name" value="MAP65_ASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="712"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="642"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="729"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="749" mass="84014" checksum="A979E81BDE9EDA35" modified="2011-10-19" version="1">MDTSYLSQQLFAALSDALQNQVRLVAAEKKDLVDEANKLIHAIRLMKSSLEDNRLRRRDDDPDLQVTYPLNRCLKFLREKHAQIRDVYRERFEEVRKVAETLESYSSHLEPGFVKLKLPPTAPNQSIPLNFDLSENYVNQLDAEFARVYEEYTRRCETVREVATNIIDLWAELGIPQSQTDPAILKFYRDSPEQLGLLESDIARLCSKRDKLVEEKKNRERRLQTLKSQVEALWEKLEVDEEERKAFLNNNRGCGLRQINEFEDELARLNELKRQNLHIFVEDARTKLQELWDALFFSEDEMLEFTPAFSDVYSDALLEAHEREIERLEHLKEQRAPCLSLIEKHKGLLRDKEELEAASQDASRLMSRGQKGEKRDPGKLLREEKMRKRIAKELPKVTAELRKVLEQWEDEYGRPFLVHGERYLDILEAEEPKPGPGPRSRTPGPNQTPGAGSKTPSAAASGLNRAKSVGHITGNKQQPITKPAGAKTPIASATSSVRSTQGLPFRTTIANKQGSPTRLPARVPLSNLKHGNNSPERPRPESRGTDTGSIRSVNGLLRAVGAAPPKMRELLPAPDLDAPVNHYRTVLGASIVRQVEPEDPYGGDTDRYSLQENSRPESNASYYHHAPSSFSASTRPRAQTVGATESSASSTSSGSSRQMSNISSSSTVVTGSENWETYDDDSAPEPDASDMYFAKLRAARRNQHQQIIMVKQRGRGIPPPAQAQAQAGAAGGPDGSKSGGSEWTDEDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6X7</accession>
    <name>G0S6X7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0027230</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693181.1">
        <property type="nucleotide sequence ID" value="XM_006693118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6X7"/>
    <dbReference type="STRING" id="759272.G0S6X7"/>
    <dbReference type="GeneID" id="18256761"/>
    <dbReference type="KEGG" id="cthr:CTHT_0027230"/>
    <dbReference type="eggNOG" id="ENOG502R17J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010627_0_0_1"/>
    <dbReference type="OMA" id="MTRPHII"/>
    <dbReference type="OrthoDB" id="196165at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030950">
        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000035">
        <property type="entry name" value="SH3 domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053039">
        <property type="entry name" value="Polarity_Bud-Selection_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47775">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47775:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="366"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="128"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="495"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="731"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="163"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="454"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="477"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="495"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="528"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="586"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="613"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="623"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="750"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="784"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="877"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="901"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="915"/>
            <end position="935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS20885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1016" mass="112750" checksum="F00DBB1F12E73B29" modified="2011-10-19" version="1">MTRPQIIRADTIDLQPADAPSAQTHRRLTPDGSIAPHQASTLREVAAETAEEILRSPRPSWHAEPDNLEQHPLVLDSHDGTASTMPLSTQHDALAIAQNGGLSGNEIDDPNMAGDDAVDIEDDLIDRISSSPSIEDGGSPLALPTLPSTRYQGPPLEPAAVRSSSPSMSEASDPGSSSPYLEGPVYLPLGFGAQHDRGRKVSRPLFDYVSSSSRHHHLDGESRLRAISAARPSTLQYEHLDPSDSDDGLSTIPEEDSYIFEDANHENKNVTSFNGQLRGGSSKVYNWRDPPIENCEPHNKRDRRLSINHDGARDDRKCYWISAEDDDLTLPYESAEDDDGDFSDVSDSRFVDSGWGGECLQETEDIDFDFVYALHTFVATVEGQANATKGDTMVLLDDSNSYWWLVRVVKDSSIGYLPAEHIETPTERLARLNKHRNIDLSASMLTDTTEKPKSKNPLKKKKNKTVQFAAPTYVDYTDPEYSDEEENVDDLATQQLQQEQHQHQHQQQQQQQHQMQQQSSLDSDMEDESARVEPLKPRSQQRDTKTETKKPETSREENKTGVRISEYADSASEWPRKTSNGTVRDSFFKDDTVETKKITLTPNLLRDDEPRTSNDSLQSKQRPSLDKLDGNDKKKKKEKEKDKKSGGLRGFFSRRDKRGGKEEEDDILGRHTDDKDEEDDNLIEKPAQRQPSKLQKPQPRVEPSPARRSNSISREPGVDIKTFLSETRLNNVANVPPATMRLVESSPKSSQERSAQDQWRQREQSPGSRGAGTRRKPQSRLEADIDNDESDEDFALEPTQKAPIPDAIIHQQPQAVQDRAVPESQPEASRAAASKISPDSAAAHKPQSEPRAESPVDVSPVDNSPSGLITSEEEAAQDAASSSPAEPVEPEEPPVPVPEAQNQPQGKAPSTRSVISPTTINTGTATGNTTASSSPRVSESWDDVSLRAFFDSGSEIRDMLVLVFDKNNVDPDPDLDNPLASSLFREENAKLAEITTRLDNMLGDWLARKQRLRGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7J3</accession>
    <name>G0S7J3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine hydrolase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0028350</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693291.1">
        <property type="nucleotide sequence ID" value="XM_006693228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7J3"/>
    <dbReference type="STRING" id="759272.G0S7J3"/>
    <dbReference type="GeneID" id="18256873"/>
    <dbReference type="KEGG" id="cthr:CTHT_0028350"/>
    <dbReference type="eggNOG" id="KOG1455">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026209_5_1_1"/>
    <dbReference type="OMA" id="SYEGWSH"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000255">
        <property type="entry name" value="Alpha/beta hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051044">
        <property type="entry name" value="MAG_DAG_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11614">
        <property type="entry name" value="PHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="28"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="317" mass="35209" checksum="BFAD3E250DF1D42E" modified="2011-10-19" version="1">MVVEKEGTFTVDNVALYSKSWLPDTTTPTKAKLLFIHGFSDHINRYNRFFAALASRGISVHGIDQRGWGRSVSHPRDRGNTGPTERVLADMAAFISSHLDDNPDKLPVFVMGHSMGGGQVLTFASHPKYQESVVRRVRGWLLESPFIGFSPEEKPSALKVMAGRLAGKLLPKQQMRHAILPENLSRDPEVVQSIKDDELMHNTGTLEGLAGLLDRTDALATGKVRPNGGAVKSLWLGHGTQDKTTWFEASKKYFEECCGEIPDKEFKAYEGWYHQLHADGEVSEEFYKDVGDWILKRCEEPAQEGAADNGGKVDAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7T1</accession>
    <name>G0S7T1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme E2 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0028710</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693327.1">
        <property type="nucleotide sequence ID" value="XM_006693264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7T1"/>
    <dbReference type="STRING" id="759272.G0S7T1"/>
    <dbReference type="GeneID" id="18256909"/>
    <dbReference type="KEGG" id="cthr:CTHT_0028710"/>
    <dbReference type="eggNOG" id="KOG0425">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_804114_0_0_1"/>
    <dbReference type="OMA" id="KWINFEE"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000063">
        <property type="entry name" value="CDC34p Ubiquitin-conjugating enzyme (E2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="10">
        <location>
            <begin position="108"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="14"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="261"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="289"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="328"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS21031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="345" mass="38213" checksum="FE89CA0252B901AA" modified="2011-10-19" version="1">MASGCFGFRLASARKRQQWLHDQGSKQPATRLNVLQSRNTKAQDRQPTPDTTTTITTTPPPPPPPPPPPPPPPPPPPPPPPPPPPPTTTTTTTTTTTTMAGRGAGASGAAQRLMSEMKALRKEKWINFEEEDTSNIFKWRFALMVINSDSVFNGGYFRAEMTFPEDYPYQPPKFRFLIPIFHPNVYPDGQLCISILHKPGEDIMSGEEASERWSPLQGAESVLRSVLLLLDDPEINSPANVDAGVIYRDRRDEYNQRAREIVERSQKDIPEGFEVPKTFDSAPPPKPETDDDFWAESDEDFDFGGSDSDEDQDMEDYDGDGGDGQADGSDEDGEGIESDYQEGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7W4</accession>
    <name>G0S7W4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">E3 ubiquitin-protein ligase listerin</fullName>
            <ecNumber evidence="5 16">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">RING-type E3 ubiquitin transferase listerin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CTHT_0037220</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Mediates ubiquitination of proteins derived from mRNAs lacking stop codons (non-stop proteins) and other translation arrest products induced by poly-lysine sequences and tandem rare codons. Ubiquitination leads to CDC48 recruitment for extraction and degradation of the incomplete translation product. May indirectly play a role in chromatin function and transcription.</text>
    </comment>
    <comment type="function">
        <text evidence="16">E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 20">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the ribosome quality control complex (RQC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the LTN1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5 16"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694147.1">
        <property type="nucleotide sequence ID" value="XM_006694084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7W4"/>
    <dbReference type="STRING" id="759272.G0S7W4"/>
    <dbReference type="GeneID" id="18257760"/>
    <dbReference type="KEGG" id="cthr:CTHT_0037220"/>
    <dbReference type="eggNOG" id="KOG0803">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015885_0_0_1"/>
    <dbReference type="OMA" id="DISKEGM"/>
    <dbReference type="OrthoDB" id="6108at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16491">
        <property type="entry name" value="RING-CH-C4HC3_LTN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000038">
        <property type="entry name" value="E3 ubiquitin-protein ligase listerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039795">
        <property type="entry name" value="LTN1/Rkr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054477">
        <property type="entry name" value="LTN1_E3_ligase_6th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054478">
        <property type="entry name" value="LTN1_UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039804">
        <property type="entry name" value="RING-CH-C4HC3_LTN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE LISTERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389">
        <property type="entry name" value="ZINC FINGER PROTEIN 294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22999">
        <property type="entry name" value="LTN1_E3_ligase_6th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23009">
        <property type="entry name" value="UBC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01197">
        <property type="entry name" value="FANCL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 15 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="810"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGS21851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="874" mass="96801" checksum="12E5847E62E296CC" modified="2011-10-19" version="1">MTELSDSLLSEKAAALRKLLDKHVPKQNPLIRVLEGQLSQAGPDSLAIDTLVQQALSSLQSESLSVEDVFPSSTEWMTELSRFFSRPPNPSLSLTSSMSGAYFLAQGGAGSANQALTRDSAGRTVTARMALFTAKLLTSGVQLASLPPEFQLELVYLLLVTASLAGDQLAVGEPEGLWNNSPEALVDMQDFLDLSSAAVEAIVAAAESWRDLDMSGDSLLERLTGFMIRETQGSGPGAFYTAKALSSLFQALVKAHGPPTRLEEWITRLGVMRLAPDTTLAASAFLSGFGGALESSKVVLTLCTRLISEIPGCSAAQPQTLPSLVLLNLTMSVYEAGQVPVETRKQVLALQQMMRWAESPEEIGHQLAAEICKAIARFLPGCKDTYGPFWEQAIEYCFWLWEHAKEAQPEERLPYIHSSLKLMQAFHGTEDPNDDLQEALESHAKDESAGLISLLTLPREAPSSLPGELVDALLSRAVSKIPHTHLTDLSGLYESVSSESKEIQKAAFGLLHRALPAVQEDINLAVILDKKAAQLPDELLSLLLNAPNPDEYSDEDLAQFPAPIRSYLLAWHLVFDAYSKASFRVRSDYTENLRKDKYLDPLLNFLVDVLGHALACALDLDKEGFTAEHIRSYSIDLADSEPAERDMNWLLIHLFYLVLKYIPGLFKMWYFDCPYKQTKNTVQSWMEKFFSPLIISDALDEVVEWASKQEGGDPDTQELVVKVNKTMREITAGYPVDDDAATILLQVPKSYPLDPVEVLSVKRVAVRDDKWQAWLKGIKAVIMFGNCSLVDGLMAFRRNISLALKGQEECAICYSIIAQDKTLPDKKCGTCSHYFHRVCLYKWFQNSGRNTCPLCRNPIDYLGADTKRRRPEHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0S853</accession>
    <name>G0S853_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SANT SWI3, ADA2, N-coR and TFIIIB'' DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0029410</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693396.1">
        <property type="nucleotide sequence ID" value="XM_006693333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S853"/>
    <dbReference type="GeneID" id="18256979"/>
    <dbReference type="KEGG" id="cthr:CTHT_0029410"/>
    <dbReference type="eggNOG" id="ENOG502S6UJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_378115_0_0_1"/>
    <dbReference type="OrthoDB" id="2240312at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000500">
        <property type="term" value="C:RNA polymerase I upstream activating factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000182">
        <property type="term" value="F:rDNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039601">
        <property type="entry name" value="Rrn5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28079">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28079:SF1">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="733" mass="82750" checksum="DCCA366549EF8B7C" modified="2011-10-19" version="1">MDVDESSHGDQSSARTTRSSRSIPIRLYSTRPLPQRAPSDEVPESDPEQGDVEDEGEEGKGSDNEEYEHQQHELNQSKNDNHQYPLAHQNLNLTTSSQPRRASYLSTSSLNSLYSPSISSISSNSSHAHQPQQTHKAFPAFASTPHRHPPHSIIPPTPSQPLPLLSSPLKRPRARGGSSASSSPGGASDYDSHGPEMVGVEEEKEEGSEQPPPKRLRHPPTSYNPSYLALLNDEILSAAEHFTPQHDWDTPLQPSQIGLIYWTDTEKTLFFEALARLGPQNAKGIAERVRTKGELEVMEYIRLLQEERDKWKRDDVVVLPEEVPAAVELTQACCAALEEAADAVAARQETYEEGVEKKKWGSGVWLVTEGNLDLVERDGRLREAAEVFRLRNWLRLSERIFMNSTVEDYNWVFVPTEDGEPRKPAIRATAVQDFHAIVVSLVRRVVAAALYVAESRIRIKKRIHPRTRAWVKPKDVEAAVLSLGLRTRADKWRRFWATCARRLRIDVVDQGEGDEEKVMDFAEVERALGVEPEVIPRYEDEDMSSSEDEGSEEEDLPNLKDEPSSPASNTSIDLAEAPSRPPSATFAKEETPSDPEDENEKATIDRELLELLHHSALELPSSRRARDALRKRLRAELRHEAHADKLDMIASQREERMLWALLGKEPPVPLGEDWEEGVEEDKVKGLGRRTVEEVVRAYKRGGGSRRGISEAPSRWEMEWKLEEQRREEVGEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8B5</accession>
    <name>G0S8B5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Modin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0021150</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692586.1">
        <property type="nucleotide sequence ID" value="XM_006692523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8B5"/>
    <dbReference type="GeneID" id="18256153"/>
    <dbReference type="KEGG" id="cthr:CTHT_0021150"/>
    <dbReference type="eggNOG" id="ENOG502SXX6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009106_0_0_1"/>
    <dbReference type="OMA" id="EKVMGGW"/>
    <dbReference type="OrthoDB" id="5227693at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="642"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="517"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="646"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="824" mass="93786" checksum="8C85E413ABDF9C43" modified="2011-10-19" version="1">MSTVNPIPNETILNATIHNATILGDIGGKDNNTVEWVALVFSIIALIATLFQLFREYSASAVGWTCCSQRVIGRWSEFRNWKMRWLQFRIEVRFETPVLFVCPPTNKRGPIKDQEPVIVTGEKRSLDETRSELPRSEEQEAAAQKLSLKDRGIHTADNERASWLELLSHLHLMEKESKEWQAQQKEYAEKRLARLGPPADNPDSLGSPEDNPDHPMSLLRRNIESVDFKKHHTLAVAVQRKKRSWDDMPSSVKKPYATTTICHILEIAAMMGIHWKEFDRCHDRYRAEGNGFMLTGTHIPDLGLMFTLHISGQSKFRENRVIPVDEVKELCCGFVSTIFQTNKDFRRVTSPAEDPKDLGLLKLGSMNEIAETMVLLDCTTDTAKIFLNKDANHMHLFAVPFELVGMLGKTLYIRNSGFRMLPNPTPYHWDRNFFDLRQVIKEFSRRLEDPERPDFRGLSDEGEQYENEKANKSLSAQQLEKLLQWSKQLSGLFKKERELNKKLQEAKAKLKGERIMNQNGNQNNGEQQSEQQSEQRAFAGRLGRATGHVRGFANSVLRNRFARNHHQGEGVEMQPQNCPHDAPLPEEIEASGHSFLLYNALYDVLKECDNFILSSDRDLVRLIIREHFQQILKMINERGASPDAISSTAGTGTAPSSHEPPTRGISRHRTTDSSGPSDHGTDGYVRAERFDQLTTEPPERRAKIFMDVYFYKVLSVVCERAVYSFESYRRRLSTISPRSNMPRTVPLSRDISSMSGGTLTSEPPAPAATVGRPDIGSLEAQATAIWCTLVLRMLCWLQLHDFDKRDVQISKSELLGSRLPVYIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>G0S934</accession>
    <name>G0S934_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Probable lysine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Lysyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0044380</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Lys) + L-lysine + ATP = L-lysyl-tRNA(Lys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="3"/>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694830.1">
        <property type="nucleotide sequence ID" value="XM_006694767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S934"/>
    <dbReference type="STRING" id="759272.G0S934"/>
    <dbReference type="GeneID" id="18258476"/>
    <dbReference type="KEGG" id="cthr:CTHT_0044380"/>
    <dbReference type="eggNOG" id="KOG1885">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008255_6_1_1"/>
    <dbReference type="OMA" id="DFRNEGM"/>
    <dbReference type="OrthoDB" id="21243at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000050">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000238">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034762">
        <property type="entry name" value="Lys-tRNA-ligase_II_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001756">
        <property type="entry name" value="PRK00484.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF9">
        <property type="entry name" value="LYSINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039101">
        <property type="entry name" value="LysRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="266"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="627"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="646"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS19945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="656" mass="74988" checksum="DCA9DD7E02397397" modified="2011-10-19" version="1">MASSNASVPNNEGSAAPAAAPKPPTEEMANLHLDEVTGEWVSKTELKKRQKQRQREADKAAKAAAAPKPTAKPKVAGGDEEKDLNPNQYYEIRTRHVAELLKNPETNPYPHKFQVTYDDSKFHEEFRHLKSGETCPERELRIAGRIYNKRASGSKLIFYGMLFFHTAVAQNVKEGALPFEKQHENIRRGDIIGIVGFAGRTNPKNRQAEGKEGELSIFATEIVLLSPCLHMLPSVRFPFSDSEQRARMRYLDMLWNDKTRQILWQRSRMVRFIREFFHQRRFVEVETPMMNSIAGGATALPFITHHNDLDMDMYLRVAPELFLKKMIVGQFGKVFEIGKNFRNEGIDLTHNPEFTSCEFYWAYADVYDLMSLTEELVSSLVKELTGSYKTTFTTQHGETFEVNWEAPWRRVEMIPELERVTGEKFPPYDQLHTEETNQFLQRLCKKMNVECPPPLTNARMIDKLTGEFIESTCINPTFILNHPQMMSPLAKYHRDQKGLCERFEVFVCKKEIANAYTELNNPFDQRLRFEEQARQKAQGDDEAQLIDESFLHAMEYGLPPTGGWGLGIDRLAMFITNNYSIREVIAFPFLREEKTAPKEKFAAEIANVQPLPEEGIRSVGLQCPGGARPAGGHHRNTGHNLTFRPAMPPPNDDSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0S994</accession>
    <name>G0S994_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">acetyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0045020</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="6"/>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694890.1">
        <property type="nucleotide sequence ID" value="XM_006694827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S994"/>
    <dbReference type="STRING" id="759272.G0S994"/>
    <dbReference type="GeneID" id="18258540"/>
    <dbReference type="KEGG" id="cthr:CTHT_0045020"/>
    <dbReference type="eggNOG" id="KOG1389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031026_1_1_1"/>
    <dbReference type="OMA" id="QMGMDHL"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000010">
        <property type="entry name" value="Acetyl-CoA acetyltransferase (Thiolase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF5">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="10">
        <location>
            <begin position="19"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="11">
        <location>
            <begin position="295"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="8">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS20005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="419" mass="44102" checksum="E54125BF97262F24" modified="2011-10-19" version="1">MSALPRGIKAVLAKAPTDVVIVSSLRTPICRSYKGQLKDAFPEELLSVVLRATLDKHPQLDPAKIDDIAVGVVLNELGGSKAARMAINHIGFPNSTSLYTANRACASSLQAITLVAAQIKTEMIDVGIGAGMESMTRNYGTRAIPVDVWPELKQSPNQDALDCLMPMGLTSENVAERYGVSRADQDAFAVESHKRAARARDNGWFDTEIVPVTTRFQEVDKEGKPVGDPKTITVTADDGIRANASLESLAKLKPAFKPTGASTAGNSSQVSDGAAATLLMRRSTAAQLGLTDSIIGKFVGSAVVGCKPDEMGIGPALAIPKVLNQFGLSTNDVQRWEINEAFASQAIYCVRELGLEKAWEEGKVNPDGGAIALGHPLGATGARMVATLMHGLGRTGGEVGVVSMCIGTGMGMAGVFVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9V2</accession>
    <name>G0S9V2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0047290</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695098.1">
        <property type="nucleotide sequence ID" value="XM_006695035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9V2"/>
    <dbReference type="GeneID" id="18258767"/>
    <dbReference type="KEGG" id="cthr:CTHT_0047290"/>
    <dbReference type="HOGENOM" id="CLU_831549_0_0_1"/>
    <dbReference type="OrthoDB" id="4842715at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="334" mass="35575" checksum="71ADB92B9A97F992" modified="2011-10-19" version="1">MHPRVAGPLGKVKQHPGFTLYALDDNSTRAVIYIDRRLTASATNAPKPALVSATMNGLTITNTAAATAALQTTPQGQVPGGHTTTPNSPFPPPAAFETRQALEEYAWAVYDVLAGVVGRFAIRPGKHTRSARWWTEVLATAREVEPVIYQEMAAYLVTQVFRPAGAQEGTGLPARLPAPPDWAAKLAAVSNDDELKDAILEATSNVAGAVPSRSALDLVQSLVHDAEPMVRQSYHELLVTVDVDSTYLSVDTTKTEVLHIPPVASGPSAIESTQRGSQLKSDFADTPTKTGLAYIRRQRASGPSPDGNRVAWGLGRGLVSLQTPRKGAGYPSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9X3</accession>
    <name>G0S9X3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11 12">Endo-1,4-beta-xylanase</fullName>
            <ecNumber evidence="4 11 12">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0047500</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11 12">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 12">Belongs to the glycosyl hydrolase 11 (cellulase G) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="4 11 12"/>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695119.1">
        <property type="nucleotide sequence ID" value="XM_006695056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9X3"/>
    <dbReference type="STRING" id="759272.G0S9X3"/>
    <dbReference type="GeneID" id="18258788"/>
    <dbReference type="KEGG" id="cthr:CTHT_0047500"/>
    <dbReference type="eggNOG" id="ENOG502RXA7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052631_0_0_1"/>
    <dbReference type="OMA" id="NMQNHFN"/>
    <dbReference type="OrthoDB" id="2115822at2759"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.180:FF:000001">
        <property type="entry name" value="Endo-1,4-beta-xylanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018208">
        <property type="entry name" value="GH11_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033119">
        <property type="entry name" value="GH11_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033123">
        <property type="entry name" value="GH11_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001137">
        <property type="entry name" value="Glyco_hydro_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828:SF2">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00457">
        <property type="entry name" value="Glyco_hydro_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00911">
        <property type="entry name" value="GLHYDRLASE11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00776">
        <property type="entry name" value="GH11_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00777">
        <property type="entry name" value="GH11_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51761">
        <property type="entry name" value="GH11_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11 12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11 12" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408936" description="Endo-1,4-beta-xylanase" evidence="13">
        <location>
            <begin position="18"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="GH11" evidence="14">
        <location>
            <begin position="47"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS20234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="235" mass="25613" checksum="BA048FC190819590" modified="2011-10-19" version="1">MVSFETLLLAVVGAATASPIALPFDPAEVTARHARGENVTEFLLARGGTPSSTGWHGGYFYSFWTDGGGEVYYWNGDNGNYGVNWYNCGNFVGGKGWKPGAARIINYSGTFNPSGNGYLAIYGWTTNPLVEYYIVENFGTYDPSSQAQNLGTFYVDGSNYKIAKSTRYNQPSIVGTATFDQYWSVRQNKRSSGSVNVGAHFQAWAQRGLNLGNHDYQIVATEGYQSSGSASITVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9Y6</accession>
    <name>G0S9Y6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutamate carboxypeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0040340</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694443.1">
        <property type="nucleotide sequence ID" value="XM_006694380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9Y6"/>
    <dbReference type="STRING" id="759272.G0S9Y6"/>
    <dbReference type="MEROPS" id="M20.017"/>
    <dbReference type="GeneID" id="18258072"/>
    <dbReference type="KEGG" id="cthr:CTHT_0040340"/>
    <dbReference type="eggNOG" id="KOG2276">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029469_3_0_1"/>
    <dbReference type="OMA" id="CNVKFMI"/>
    <dbReference type="OrthoDB" id="7832001at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05676">
        <property type="entry name" value="M20_dipept_like_CNDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF4">
        <property type="entry name" value="CARNOSINE DIPEPTIDASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="6">
        <location>
            <begin position="293"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS19558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="560" mass="61994" checksum="8732C782249BE646" modified="2011-10-19" version="1">MPRTPLTIPPHLLFPGRCLDCSLRGFLFANFSSLRSINTAAAARVLPSQIPTRRRTSHNNTSPATFSNPRQPYLTDAIRAHQARKMAPQLNGYFQQVDALADAFIERLRQAVAIPSISADPARRPDVVRMAKFLESELIKLGAQVELRELGRQPGSDVNLPPVVLARYGNDKNKRTILVYGHYDVQPAEKSDGWDTEPFELTVMPDGRMCGRGATDDKGPVLGWLNAIQAHQAAGIDFPVNLLMCFEGMEEYGSEGLDDLIYEEAKKFFADTDAVCISDNYWLGTERPCLTYGLRGCNYYNIEISGPGADLHSGVFGGTVEEPMTDLVRILSSLVDTNGKIQIPGIYEQVAPVTPEEEGLYDDISFNMETLYESLGSKTTIYDDKKKTLMARWRFPSLSIHGIEGAFSGAGAKTVIPAKVIGKFSIRTVPNMDIEKTNEAVSRYVEAVFKSLGSKNTMKVYPQHTGMWWVASPNHWNFTAAAKAIERVWGVKPDFTREGGSIPVTLTFEKATGKNVLLLPMGSSTDGAHSINEKLDKRNYIEGIKLLGAYLHYVAEEPME</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAJ3</accession>
    <name>G0SAJ3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0042490</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694650.1">
        <property type="nucleotide sequence ID" value="XM_006694587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAJ3"/>
    <dbReference type="STRING" id="759272.G0SAJ3"/>
    <dbReference type="GeneID" id="18258287"/>
    <dbReference type="KEGG" id="cthr:CTHT_0042490"/>
    <dbReference type="eggNOG" id="ENOG502QSCZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016311_1_0_1"/>
    <dbReference type="OMA" id="AEWEDTT"/>
    <dbReference type="OrthoDB" id="5430106at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22794">
        <property type="entry name" value="THAP DOMAIN PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22794:SF2">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="588" mass="62549" checksum="E1D4D6A66ED78B0C" modified="2011-10-19" version="1">MAKDRDGEASGANQSKKPTSGVLDNGDQPPQQHLPHHHHRKAQKPHIVGGGPGSRLHARVPSSKALHKHHALASTTKLTRAISPERGNGVAHHRRISSQDRLPANSKKNLSHTALRRNRSQVEVTKRTKSSTNLQRSNSNSAVHKLKSKVQFNLGDDEDDQDGEDEWVDASSSASPYLSRRGSAVNTAQTNNLTVGSQDPLRRDSVNSEQTTSNENLARSSSNLNQLLTSKVLSRTPSQGAPPVMSTATVSVQPSAQQLSSQASSPGQGPSYTSTTAAAAQCRPGSSGKAELTSRFVGGNNSQEQGAGSGAAEEAFMMAANRGGLSRAALNGKVGLGMQRRQSSGALSQGRGMDALNARQGGASDSEDEEAALRPRRAAEFIVPRDMNRTQKKLNLQRASSSLEPTHPHPGVGVRPPGVGMGPGASSAFEGRDPRGSKLLERTGMEYLTVRRYLNPVALSLHRVMQLPGLENSRRIPRPGTSHSVRASGSDVDSLRDPSMADLMSGQSRTTSRQATPRSRAEFSLGVDSASSSYGADNDRLQEQASRAPSQHRLSGSSLVDGVEDAGTIALLRMMWDKTMDLGGSSQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAM8</accession>
    <name>G0SAM8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0042840</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694685.1">
        <property type="nucleotide sequence ID" value="XM_006694622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAM8"/>
    <dbReference type="GeneID" id="18258322"/>
    <dbReference type="KEGG" id="cthr:CTHT_0042840"/>
    <dbReference type="eggNOG" id="KOG4300">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037990_3_1_1"/>
    <dbReference type="OMA" id="CPRICSY"/>
    <dbReference type="OrthoDB" id="416496at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050508">
        <property type="entry name" value="Methyltransf_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42912">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42912:SF83">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS19800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="495" mass="54425" checksum="62E3678C3A92BC14" modified="2011-10-19" version="1">MKPQRCWGRLTRLQRLGCSPLCFRPAPRLNISPNHSPKYPARFNGTTNVTGPFKGTDILQRGARIRVQPRAQVASSTGTSSFAPQGGQGPQTKAQSLDVLLQERKWPLIGAGFMALGIGLYVSIVITSSLKKDREEKQTLQTQKPVRTPCTCTSSLPSLQPTPSGLPAILQDPTISPAARHTSAISFDRGLDLPEWLTGIKKLRKAIGATVRGHVLEVAVGTGRNIAHYDWSEVVIPPGEDPVAREQRQQEKIRKLLDKHLLGRDDGSLSSGELMSVREYKERGIGSLDGELLSFTGVDVSGGMLAVARDRVRENVPGLSKVMRRRRAEPMPELGPEHTESEVVVNALDNRIRLVLADALHDLPAPAARDERTGKVPEKYDTIVQTFGLCSVSDPSALLAKMAAKVQPDTGRIILLEHGRGWWDWVNGLLDKYAPSHFEKYGCWWNRDIEKLVRDAAEVVPGLEVVSLTRPLVFQAGTTLLIELKVSSQKARKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAM9</accession>
    <name>G0SAM9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trafficking protein particle complex subunit 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0042850</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694686.1">
        <property type="nucleotide sequence ID" value="XM_006694623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAM9"/>
    <dbReference type="STRING" id="759272.G0SAM9"/>
    <dbReference type="GeneID" id="18258323"/>
    <dbReference type="KEGG" id="cthr:CTHT_0042850"/>
    <dbReference type="eggNOG" id="ENOG502QV3F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003572_1_0_1"/>
    <dbReference type="OMA" id="SIYACFY"/>
    <dbReference type="OrthoDB" id="6278596at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012880">
        <property type="entry name" value="Gryzun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021773">
        <property type="entry name" value="TPC11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14374">
        <property type="entry name" value="FOIE GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14374:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11817">
        <property type="entry name" value="Foie-gras_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07919">
        <property type="entry name" value="Gryzun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex subunit 11" evidence="3">
        <location>
            <begin position="340"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="Gryzun putative trafficking through Golgi" evidence="2">
        <location>
            <begin position="638"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS19801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1259" mass="141030" checksum="D145B8C68840A58C" modified="2011-10-19" version="1">MDDYPPGCLDHSVPFLLTLGTCTDTPYDAKLSHALKEQAILIRSELPALDSDQARALMRYMQDRDASNSPCNARNETTRKYRFHIKSAERSLLLPPRRARLPDGFEPPSPTSATVLHSPYSPLSPVSPLYPDGLINTDWIRKHQDLIPSILLCFYTLVSDPTLSTLCDNQIKTDVNNIRALLSQSGYKTKLAVVLLSDGTNPASMEGVQERLDVIRRGCNLDAKALFLVPPNESQEELERVAENMLTTLYAVSLEYYRDLGRHARKKRSRGIAPQPTVPPTSGTSQTLSLAGWNVRYDFKTATFAEYRLEMDVALRSYELAYEALLSTEVMELIPSWSPRWNEARLLADIIAIRCIRCLLWNGQHSAASRRWQFHRERIADFVDRRGRGTNNYGWAAWEARWAAVMADLIDKADIPELAPSSGRLYLPPEKSVMGERLQPWELLHHQGYWHRMAARHTQTRRALARTIPESDRQPPSASPASLVAKSAFTYDTYMCPDPYEEYPIDGIGGGVEHGKLIVDRLIRARSEFLKRGQKRLAAEVSLECARELGMAERWEDVIKLLRPLWQDMPFRTEGWIPIIEEMDWLLRRAAYEEDEAELLLMIDWELHSQSFSKRPNWEYNLAKSLEDIETAEKPDIYIRHGQLISPVAASFLFRDEEGKAGQSVHCQLTIRSNAHQGSALLQLSSVQVNFSGGIGTVVLQHEDVDDTRQKHGNIVLSSLTLTTRESGEDDVKSTSAGSDGEKSAVLKGTADLRLPPGQVLVFNLEIPLREPGDAHAESVVVTIDNDEFKLNQSISFAENSSRNLWYISASAVKHIAHQRPLSLHVLPRPPKMEVRSLGWKEQYYTDEPISLEFEIENGEDVEALSKLDVTLFGEKPSSFTVDLPSGESQTSSSIRSEESRLSGAQLGAIASAKSLTIRLHLPPIESSSRHDLTLKVTYFLPTNPGTPISQTAVFQLNIVNPFEASYDLLPRVHPDPWPSVFDPDTVAPLPGPNSPDTPSFIPKGLSQAWCLVTRYASFASEPLRVTEVSVQISPSPLFRCTAVATKHSLPEDGSGRLIQPKTIEQAAFELTAQRATLDERGPAPLDMALTIRWTRAEGGNLEKVNTTTLPIPRFNIFGTEPRVLATVSYRRRGNTKDEGSGGHLVIVLTVTIENASSHFLTFGVSMEPSDEFAFSGPKMTTVNVLPVQRRSVEYRLLPLDQKDEDDNGEKGEHQGWWIRPGLMVRDKYFQKVLRVLPGGEGLRRGEEGLEVWVPGARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAQ2</accession>
    <name>G0SAQ2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0043090</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694709.1">
        <property type="nucleotide sequence ID" value="XM_006694646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAQ2"/>
    <dbReference type="STRING" id="759272.G0SAQ2"/>
    <dbReference type="GeneID" id="18258347"/>
    <dbReference type="KEGG" id="cthr:CTHT_0043090"/>
    <dbReference type="eggNOG" id="ENOG502QQ65">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_860780_0_0_1"/>
    <dbReference type="OMA" id="GYEYNVP"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="296" mass="26984" checksum="0DAA510F3B06518D" modified="2011-10-19" version="1">MPGVPLGALDNLVDKLKLAFKKRHEKKGVAAQKPAEEQPATSATPAPAPTTTETAAAPAPVAAPAPAPAPAPAPAPAPAPAPAPVQSVEAAAPATAAAPAPAAPAPEAAPAPAVAAPEPVAAPTPAPAVPAAAPEPTPAPTTTEAAVAAPAPAAPAPAVENPAPAATPAPAVAAEPTPAPAPASTPAPAVTPATPAPAPEPAAPVAPTPTAPAAAPVEAPVAPAPAAPAAAPTEAPAAPAPAAAPAPVEATPAPAPAAPAVTEVSAATAATPAPAAEEKKEEAAAAAAPAPATTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAR0</accession>
    <name>G0SAR0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative RNA polymerase II transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0043170</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694717.1">
        <property type="nucleotide sequence ID" value="XM_006694654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAR0"/>
    <dbReference type="STRING" id="759272.G0SAR0"/>
    <dbReference type="GeneID" id="18258355"/>
    <dbReference type="KEGG" id="cthr:CTHT_0043170"/>
    <dbReference type="eggNOG" id="ENOG502QRVJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005701_2_0_1"/>
    <dbReference type="OMA" id="NIARRGW"/>
    <dbReference type="OrthoDB" id="5426978at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF26">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="299"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="221"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="379"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="844"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="893"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="82"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="155"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="972"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="986"/>
            <end position="995"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS19832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1029" mass="111497" checksum="E2658CA3AF25EFD2" modified="2011-10-19" version="1">MDEKNPPQPAGDVAMREPYPEPMVADDAQYYQLASHQEQEPQIGQQQAVKPETPTLPNIAMEQQQPTQEQQHAPHPHELEGLQSLPEQQAPQEQQQPPQEAQISPQQQIQEQQDQTQQSRPAADAVDELQLAAQLTQNLAPMMVPVRMDGVPSEPQDQQALPQQDSDVSNNTETNLQEQLEASLQHHDREMQNHAAELQTPQEHHQHHHLQNHELQAHGLSNMLSPTTQPPQHHYAQAQGAPAPPPPPPPHAQIHPHLQSHLPPEHHHHLGPGAGAPGYSMGPDGTGPPARKRTKVSRACDECRRKKIKCDAQCETSDEPCSNCRRSNVQCLFSRVPQKRGPSKGYIKELADRINSIEGKLNSTRVEALDTLTRRASSDMFGTPIGDESRKRPFSSISSDGFPAASPTRMAVAGEHRPIVPYPPDFPPMNPNHPNHITSRLLDGIQVNADASDISLQQPEAGASEIAPAPAQEQLPEVEDTVFESYLQIIHPTFPILASTKARVQYLVFQTPLTLQKAFYHAFYSMIGPFLPSPESQPYGSPSTARRLLSSWEEECIPRTATTDLVRLLTLIMLGIGHDLDGIPAVKGQLGGPSKAEMVGRAVGLAHSMNLRVKAAKLDASSPLDPDTDSNWAVRAWWVLVMLDRWTALGAATPALIDNDSAVIVPALKQLVGEVVYHLIRISVRLGQIIPLAITSPRELGASSKVIFDSIVGMSVEDVRLALPNNESDPILLLSYWHLRLLCDLLSSSPSRRRNILQAASSLVWLLAQNHDLRSPLTHHFLTLASVALSELLASSSSSTNTPDENNKLRDEAAKLIDLVLQFRLSPSPWNEAVRKTLADRLGVPVPQHPTAGPNGHENGVNGAGTEAAADQNLQQLADLATAANHAFATATAPTGEPAGQQVDGRAAEQQPVASTPAPAPADVNSNSTPATAPGLAPEQASNLKSEPGMSGGPTPPAAALVDGFPAVDAGPSNTDATNQGAPVLQQQQQQQQQQQQQTFDTLAVLRAGYLASFEGVPVEGQDVDVMEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAS1</accession>
    <name>G0SAS1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0043280</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694728.1">
        <property type="nucleotide sequence ID" value="XM_006694665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAS1"/>
    <dbReference type="STRING" id="759272.G0SAS1"/>
    <dbReference type="GeneID" id="18258366"/>
    <dbReference type="KEGG" id="cthr:CTHT_0043280"/>
    <dbReference type="eggNOG" id="KOG1211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_0_2_1"/>
    <dbReference type="OMA" id="SWPGANH"/>
    <dbReference type="OrthoDB" id="421993at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF67">
        <property type="entry name" value="AMIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="3">
        <location>
            <begin position="179"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS19843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="647" mass="71112" checksum="697AE1163F16DEA1" modified="2011-10-19" version="1">MAPSKKFVNGPDPLKGQVFQFHVYRARGITDNLRPDVPYAEAKTKKNPVLRGIWLFCAAFLMEWFRFIRERIWRHTGFDSLRRIIPYIEDYEPWYEPLVIPRPDDLSQKVDSLDSGQAQTSPTNESQDEEDDEEEKFPTPPLYYTIQDYRRAYLSGTLTPTDVVRSILGLIHPKDAPHSQAVTATLIPSALAAAEASTERYKQGRPLGPLDGVPTVVKDEYDVAGYQTTLGSRNIYASTEDGHPSTWCVQQLEQAGAIVIAKSAMTEFGLDATGNNPIYGTPRNPYNRRYYTGGSSSGTGYSVAVGLVPVGLGSDGGGSIRIPAGFCGVFGLKPTHGRVSFRPGQNHSITCACLGPMAADIESLATVFEVIAKPDPSSHFPELKSPLDLRMPPPSSDEEDPNRLLGIPIAWVSQASPAVQTLINSLIRKLTTTHGFRTVPISIPFLPEGQLAHAMTILTDAATLLPPPPATRNLTPANRLLLALGRTTPATDYLLAQKLRRLLMQHLAWLWEQHPGMLIITPTAGCAGLKIGRESDAVQGGFGVSDGDSTMECMRYAWLANFCGLPSLSIPVGFVQARGGDVPVGMMVTGEWCAEERLLRFGRVVERVLYEEGMQGRRRRPGCWVDVLERARGRARERAAESGEERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0SB29</accession>
    <name>G0SB29_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallopeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0048680</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695231.1">
        <property type="nucleotide sequence ID" value="XM_006695168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SB29"/>
    <dbReference type="GeneID" id="18258906"/>
    <dbReference type="KEGG" id="cthr:CTHT_0048680"/>
    <dbReference type="eggNOG" id="KOG4525">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009601_2_1_1"/>
    <dbReference type="OMA" id="MFRNNFG"/>
    <dbReference type="OrthoDB" id="74460at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.30">
        <property type="entry name" value="Jacalin-like lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001229">
        <property type="entry name" value="Jacalin-like_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053002">
        <property type="entry name" value="Metalloproteinase_M10B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021917">
        <property type="entry name" value="Unchr_Zn-peptidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054:SF2">
        <property type="entry name" value="MIP04191P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054">
        <property type="entry name" value="ZINC METALLOPROTEINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01419">
        <property type="entry name" value="Jacalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12044">
        <property type="entry name" value="Metallopep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00915">
        <property type="entry name" value="Jacalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51101">
        <property type="entry name" value="Mannose-binding lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51752">
        <property type="entry name" value="JACALIN_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Jacalin-type lectin" evidence="2">
        <location>
            <begin position="723"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS19409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="875" mass="93728" checksum="C75F8EFBEF456F3D" modified="2011-10-19" version="1">MSPSFLTTLKDLRRRSMASFRSNDRSPSSDSASSSSSSSSSSSSSSSAENNQHSQNATNTTISTPSSLTPGTNTPGDVTPPSGIPIPSQKSDTALNLRVREPGTTEVRRPKSQLVHSTTSGNRLSVSPGQVAAPSLLPGPGRFPAPPLPAMMSGAVAGTQMSPYAPRVVNVPDGSWVYQKLLLLTGHIGPSPQSYSLDGTITITRLNNNLNPPDPSSDPAIPPLSFPVCASHFKALVYLLPGANRFRIEFVSPKLKDVTANGVNVNVTYLTVHMIPPTSTPPLHLVILLAKDSPGVFDAPPSRVEREGNGLETAVRKFRMAAYLWQAFTAEQMYRNRLGRRTVRFEEEWTVGSVGKRDWEVGVLRSEARVHVIRSEKTIAELRDPERAQQNENAGDKGGLFGIAADAVRDYFKPSKGQKIYAATLLLDAHWDVEKQLITGHAALGGSVGNLHLAVFGSHCLWSYPPCLEDVIPSFTDCTPTDTSHVANDCGDAPCAWEALCLGVGAHLHEVGHALGLPHRDSGVMARDWRRLNRVFVVREGFSARTKSRGGFVGELEDGEGCSWHRLDCLRLRSHALLRLPNDAGLGEPGVEVWVVEEGTVVVTAGSGLQVVEVYDEGEEVCRVWIEYLPSAPGEGPLRMVTLTEGELRARLRQGHPKYVGKEGPKGTIKIVVRSCAGGAAEIEDFGALVSRETSVLRLTPSNSNTNSTAAALGSMLPGSAPPTRTAFKGKKVGQAKLEGSEPVEVVFASALPRAAGEKGVVLSKVVVYHGAAVDGVEFVYDDGGVQLFGRRGGKGEGFEMDVRRGEYLTGFFVRAGSWIDAIQILTSLGRRSPLYGNANGGDPHTLIPPRGYTVCGVTGSCGQWLDSFGVIISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0SB89</accession>
    <name>G0SB89_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0049300</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695291.1">
        <property type="nucleotide sequence ID" value="XM_006695228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SB89"/>
    <dbReference type="STRING" id="759272.G0SB89"/>
    <dbReference type="GeneID" id="18258968"/>
    <dbReference type="KEGG" id="cthr:CTHT_0049300"/>
    <dbReference type="eggNOG" id="KOG1401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_1_2_1"/>
    <dbReference type="OMA" id="WGPLIFG"/>
    <dbReference type="OrthoDB" id="425114at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43713">
        <property type="entry name" value="GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43713:SF3">
        <property type="entry name" value="GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE 1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS19469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="444" mass="48162" checksum="B6B0022EC0FD732F" modified="2011-10-19" version="1">MDSRTSHAAASKALLAAEARYITNNPLSKQIYDQATSSLPGGNTRTVLHTFPFPLAITHGKGAHVWDADGHEYLDLVGELSAGLYGHSNPTIHNAIQRVLSSTGLSLGGQTPYEQRFASLLCARFHLDSVRMTNSGTEANLHALAGARRFTGRRKVVVFSGGYHGAVLSFPDGKPAENVVDKGDFVVVPRYNDVELAQEVIRKVGNELAAVLIEPMQGAGGCIVGKRAFLHAVQEVAREVGALFILDEVMTSRLAPGGLGAELGLKPDLMTMGKYLGGGFAFGAFGGREEVMRVFDPREPGALAHSGTFNNNTMSMCVGATGLEEVFTPEVCVKFNAKGDSLKKRLQDIARGTRLTFTGRGSLIGLHFTEDGMQDIICGEDLKGRDRKDLRDLFWFEMLEAGYWITRRGFIALILETSDDELDAFVQAVKEFLQKHKNLMTVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBG9</accession>
    <name>G0SBG9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Acyl carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CTHT_0050230</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="18 19 20" key="2">
        <citation type="journal article" date="2022" name="Sci. Adv." volume="8" first="eadc9952" last="eadc9952">
            <title>Conformational changes in mitochondrial complex I of the thermophilic eukaryote &lt;i&gt;Chaetomium thermophilum&lt;/i&gt;.</title>
            <authorList>
                <person name="Laube E."/>
                <person name="Meier-Credo J."/>
                <person name="Langer J.D."/>
                <person name="Kuhlbrandt W."/>
            </authorList>
            <dbReference type="PubMed" id="36427319"/>
            <dbReference type="DOI" id="10.1126/sciadv.adc9952"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.44 ANGSTROMS)</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695371.1">
        <property type="nucleotide sequence ID" value="XM_006695308.1"/>
    </dbReference>
    <dbReference type="PDB" id="7ZM7">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.77 A"/>
        <property type="chains" value="O/Q=1-141"/>
    </dbReference>
    <dbReference type="PDB" id="7ZM8">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.76 A"/>
        <property type="chains" value="Q=1-141"/>
    </dbReference>
    <dbReference type="PDB" id="7ZMB">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.75 A"/>
        <property type="chains" value="O/Q=1-141"/>
    </dbReference>
    <dbReference type="PDB" id="7ZME">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.83 A"/>
        <property type="chains" value="Q=1-141"/>
    </dbReference>
    <dbReference type="PDB" id="7ZMG">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.44 A"/>
        <property type="chains" value="O/Q=1-141"/>
    </dbReference>
    <dbReference type="PDB" id="7ZMH">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.47 A"/>
        <property type="chains" value="Q=1-141"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBG9"/>
    <dbReference type="EMDB" id="EMD-14791"/>
    <dbReference type="EMDB" id="EMD-14792"/>
    <dbReference type="EMDB" id="EMD-14794"/>
    <dbReference type="EMDB" id="EMD-14796"/>
    <dbReference type="EMDB" id="EMD-14797"/>
    <dbReference type="EMDB" id="EMD-14798"/>
    <dbReference type="SMR" id="G0SBG9"/>
    <dbReference type="STRING" id="759272.G0SBG9"/>
    <dbReference type="GeneID" id="18259061"/>
    <dbReference type="KEGG" id="cthr:CTHT_0050230"/>
    <dbReference type="eggNOG" id="KOG1748">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108696_0_0_1"/>
    <dbReference type="OMA" id="RFKTPRD"/>
    <dbReference type="OrthoDB" id="448946at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099128">
        <property type="term" value="C:mitochondrial [2Fe-2S] assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000035">
        <property type="term" value="F:acyl binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000003">
        <property type="entry name" value="Acyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002148">
        <property type="entry name" value="PRK00982.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="ACYL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863:SF28">
        <property type="entry name" value="ACYL CARRIER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="18 19 20" id="KW-0002">3D-structure</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Carrier" evidence="15">
        <location>
            <begin position="62"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGS19549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PDB" id="7ZM7"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="19">
        <source>
            <dbReference type="PDB" id="7ZM8"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PDB" id="7ZMB"/>
        </source>
    </evidence>
    <sequence length="141" mass="15575" checksum="52302C0C8DCA2621" modified="2011-10-19" version="1">MFRSAVLRSAAAATRTTIRSIPPAAAKKFAVAPVSRVTSFIPKTASWQVIRCYASNEGLQKVEVYERIKSLLAGFDKVNDPNNITETAHFANDLGLDSLDTVEVVMAIEEEFSIEIPDKDADQIHSVDKAIEYILRQPDAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G0SC68</accession>
    <name>G0SC68_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Putative lipid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CTHT_0056130</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695939.1">
        <property type="nucleotide sequence ID" value="XM_006695876.1"/>
    </dbReference>
    <dbReference type="SMR" id="G0SC68"/>
    <dbReference type="STRING" id="759272.G0SC68"/>
    <dbReference type="GeneID" id="18259651"/>
    <dbReference type="KEGG" id="cthr:CTHT_0056130"/>
    <dbReference type="eggNOG" id="KOG1012">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001661_0_0_1"/>
    <dbReference type="OMA" id="DHFYGDW"/>
    <dbReference type="OrthoDB" id="1029639at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04044">
        <property type="entry name" value="C2A_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04052">
        <property type="entry name" value="C2B_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04045">
        <property type="entry name" value="C2C_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04040">
        <property type="entry name" value="C2D_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21678">
        <property type="entry name" value="SMP_TCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037761">
        <property type="entry name" value="C2A_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037765">
        <property type="entry name" value="C2B_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037762">
        <property type="entry name" value="C2C_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037756">
        <property type="entry name" value="C2D_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056910">
        <property type="entry name" value="TCB1-3_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052455">
        <property type="entry name" value="Tricalbin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46980">
        <property type="entry name" value="TRICALBIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46980:SF2">
        <property type="entry name" value="TRICALBIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24920">
        <property type="entry name" value="C2_TCB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25669">
        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="162"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1948"/>
            <end position="1973"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="15">
        <location>
            <begin position="222"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="423"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="566"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="692"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="1077"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="1309"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="14">
        <location>
            <begin position="1495"/>
            <end position="1667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="860"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1265"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1442"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="881"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="927"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1267"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1451"/>
            <end position="1465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGS18994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1993" mass="222195" checksum="E7FE03AC0739BA17" modified="2011-10-19" version="1">MASEKDASAGPVRSNTLEIEAAERKIIEESRAAGVAAFSFDPNASHEQKVAQARAAIPPGFHKRPHGVAVVTDMDDGTKADIDLPSPTKSGVVDFPKAESKKGAEGKTEESEDEIWARTGWAPRFGWPTEPIIEAESMLDHQTWVETQLPEQFYGDWYHNAAIIVFACLASWFVAVLGGGLAWVFIIMAICATYYRTSIRRVRRNFRDDITRELALKKLETDNETVEWINSFLVKFWPIYQPVLAATVINTVDQVLSTATPAFLESLKLKHFTLGSKPPRVEHVKTYPKTEDDIVMMDWKFSFTPNDIADMTARQIKNKINPKVILEIRVGKAMVSKGLDVIVEDMAFSGLMRLKIKLQVPFPHVERIEMSFLERPTIDYVCKPLGGETFGFDINFIPGLESFILEQIHATLAPMMYAPNVFPIEVAKLLAGTPVDQAIGVVAITLHGAQGLRNNDKFAGTPDPYAVVSLNRRAPLAQTKVVKENANPRWDETHYVLITSFSDSLDIDIYDYNDIRKDKKLGAASFPLENLEEIYENENERLELSLDGKARGVLIADIRFFPVLEPTKLEDGSIEPPPESNQGILRFTVEQAKELDSSKSMVGLLNPYAVLLLNGKEVHTTRKLKRTNDPIFSDGSKEILITDKKHAKLGVAIKDDRDIAGDQVVGTYQIKLEDMLELMAQGKDWYNLAGVKTGRVKMTAQWRPVCITGISTGTGGYVTPIGVMRIHFKHARNLRNVEALGKSDPYARIVMSGIEKARTVTFKNELNPDWDEVLYVPVHSPRERIQLEVMDAENVGKDRSLGLTEISCADFVHKDPETGEWLVHDAKEVREDGLRMHGKGTPKGTLTYTVAFYPTLNVADPEEEEKEEQKAKEQEQQGSEKTSDTEGDKDKPSSNRPSLDGRGSARPSLDIAKANGLKEPPTPLTPSSPSSALLSPRKSREEREPPKIYLTPQELLKYESGLIIFRLMEAELPKSGVRVEVFVDDMAFPSYVSSAAKSKSHTFNEIGDCFIRELEFSKLHVKISEKSDKQGEDNKQNVLARLSGNSIDVLKQCLNNPTTLKLRDEDGNTYSLKVSLKYVPVKMTLDPSESINNMGNLRIDVLDAENLPSADSNGKSDPYAKFEFNGQEVFKTKTVKKTLNPEWNENFNIAVPSRTAAKFRATVWDWDFADKPDYLGGVDIDLTQLEPFQARILKLPLDGKSGTLRLRMLFTPDYVTRTRHGTSTLAGTFAVPGKVLTGVAGVASMPLKGGATVVGKGASLIKRGFRGKKDDDKDSDSSSNSSADIPAIVTENADDDRENRPLHHVRTRSAGASSVHSAIIPGAASGTASFTVVSAAGFPPSADVYVVITQVQDGKAKQVGKTKHRKQSSGPVRFDETFRIKCTPDATFKVEAKEHHTFGSDDHLGEALYYVDDSNTGAEKTLNVGSGTVVIKSSFVPEEKEGYVSGGSKGPSLSVTDSPKSQLPSLGTIHCPRQPLRPMGERGTVNVNLSSRAQMNTTGIPTRHNATVGAMAARVRQFAATHTPFRVYHGSSNSTRRSDRHEDNIIDTSKLDQVLRVDPVRKTALVEPNVSMDKLIDITAHYGLVPRVVMGVPGITVGGGFSGTSWESSSFKWGPFDATVNWIEIILPDGTVQMASKTEKPDLFWGAASAFGTMGIVTLLEVQLMNAKRYVELTYRREGDFGQVVETLLDQTALGTSNDYVDAIVFAKDSTLICTGQLTDALPRGAVPQRFLRARDPWFYIHAERIEKQLRRSPPNTKLRDYVPLVDYLFRYDRGSFWTARYVFQYFLTPLNRYTRFVLDPLDVGIPVPRAEEFVEWVDANLHIYPLWLCPVFVRRLERNSQYGLHADFGAPDGPDIYLNFGIWGPASSSQGDALRKNRALEQEVARLGGKKWLYSHVYYREDEFWEQYDRRAYDRVRRRYGADYLPSVYEKVRLDSEAEDAATRVTWIAWLFAIIWTIWPLRGLLALIRAVLGRDNLLQQRHNGLRRLIGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0SC79</accession>
    <name>G0SC79_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0056250</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695950.1">
        <property type="nucleotide sequence ID" value="XM_006695887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SC79"/>
    <dbReference type="STRING" id="759272.G0SC79"/>
    <dbReference type="GeneID" id="18259663"/>
    <dbReference type="KEGG" id="cthr:CTHT_0056250"/>
    <dbReference type="eggNOG" id="ENOG502SDZT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018065_0_0_1"/>
    <dbReference type="OMA" id="GMKRGDW"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="130"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS19005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="595" mass="67780" checksum="5E22271A844CE011" modified="2011-10-19" version="1">MDLNSASIHDVIHPTAAFSQNSPPANHPTDPPEEVPWSESQLNPKNRVNSLDPPQNPRWRIDGSTGLGTQFYALPLNAGPLPPMRFDVFIPEEAGLSPRLREILSLNAAFHTKDADRVRRLGITNHILRRLQTWMAGEGELKSLYENLPFGSRIILENLDLDLSKMRITVAPTYYLEKQLLALAKLDKALGVPSEQLPQAVDIKNLVIVQQLSDSVCIVRLSPGKTDDGTAHGNDKLWILKALTSGVKYMYVELRNLLLMKPHPNVISRPDYLVTKICSFGGKRAVVGFMLPYHSGGGLRDMLPLLRINGRLTMDMRLKWAIQLTSAVLHVREEGRMFYPDLRLDNIILSETGDLIMVDFEQRGVWCEFAAPEINAIDFIRILATRSVGDSGNNGNETGIPEDTRKYYASILSKLMPDWEKLQSCEEYPPLDGAYQSYIIPWLCLDEREQEAAEVFMLGRVLWCIFEGQSAPHHVTPWQSYLREPDIEFPAYRYTPVVLRDLIDRCTRGRRPGLSSLIVRQKSKLVLRGTVGESSPEEVMKAAREYWRAEVEEAERFVWLREERKRQGAWDGNHFGRPRLREVLRELQAFRDAYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCN1</accession>
    <name>G0SCN1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CTHT_0057820</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 23">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696102.1">
        <property type="nucleotide sequence ID" value="XM_006696039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCN1"/>
    <dbReference type="STRING" id="759272.G0SCN1"/>
    <dbReference type="GeneID" id="18259820"/>
    <dbReference type="KEGG" id="cthr:CTHT_0057820"/>
    <dbReference type="eggNOG" id="KOG0230">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1729">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022550_3_0_1"/>
    <dbReference type="OMA" id="ICHTQFS"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16489">
        <property type="entry name" value="mRING-CH-C4HC2H_ZNRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051878">
        <property type="entry name" value="ZNRF_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNRF1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661:SF4">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="15" id="KW-0458">Lysosome</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="20">
        <location>
            <begin position="240"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="19">
        <location>
            <begin position="537"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="70"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="284"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="330"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="425"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="159"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="338"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="369"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="426"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EGS19157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="585" mass="63693" checksum="010493EFA9B64587" modified="2011-10-19" version="1">MASRDNRPFSSDVHEDAESSSSSHIHHPDSTSSHDGQDNRSRVICPWRTPRYYNQECSRYFDCPTHTVERALSEDAEEEREDETTQEARHDRPQSGMSTSDDTGNEDGPQMTDPGPPEPRTATTAGAPSHPPQLARSRSPPGSSAGNPIMLDAPPAAPPRQRLAPSALSESQRGSVNSSSGGVSTSPAPVGSLSRQSRVSAAAAALSQAASQAGQSSSVAQNPVDVHPGTPVVLPRWQPDAEATYCPICHTQFSIFNRKHHCRKCGRVVCASCSPHRITIPHQYIVRPPGSSSPVPQRSSSSSHESHSLFPDFSGGERVRLCNPCVPDPNTAPPFAQQGHSSQASTLLPSLQPTTSPTSNRWNYYFGAPTSSSDPLARNRSATMSHPTRGPPSLTSGGYAQPSTSYTHNAYPGYYYQSMLNLGEPSSAAASSSGPSSSTSALNRQPLRSQPEREIPEEDECPVCHRELPPRTLPDFEARREQHINDCIAARSNMYNRSRAASSSAAGESSTAMPRPRYTRMFPYTATEKDCVDDAECTICLEEFEVGAQMARLECLCRFHLRCINAWWERHPGRCPMHQHDGYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCN7</accession>
    <name>G0SCN7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Putative bifunctional purine biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0057880</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis. Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). Also catalyzes the cyclization of FAICAR to IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PurH family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696108.1">
        <property type="nucleotide sequence ID" value="XM_006696045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCN7"/>
    <dbReference type="STRING" id="759272.G0SCN7"/>
    <dbReference type="GeneID" id="18259826"/>
    <dbReference type="KEGG" id="cthr:CTHT_0057880"/>
    <dbReference type="eggNOG" id="KOG2555">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016316_3_2_1"/>
    <dbReference type="OMA" id="IKHNNPC"/>
    <dbReference type="OrthoDB" id="6017153at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01421">
        <property type="entry name" value="IMPCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.20:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.440:FF:000001">
        <property type="entry name" value="Bifunctional purine biosynthesis protein PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024050">
        <property type="entry name" value="AICAR_Tfase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005492">
        <property type="entry name" value="PRK07106.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692:SF0">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN ATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="13">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS19163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="593" mass="65151" checksum="D881D353BC71E177" modified="2011-10-19" version="1">MADQRIAIISVYDKTGLLDLAKGLVKNNVRILASGGTARMIRESGFPVEDISAITKAPEMLAGRVKTLHPDVHAGILARNLASDEKDLAEQNINKVDYVICNLYPFKETVAKVNVTIPEAVEEIDIGGVTLIRAAAKNHARVVILSDPKDYPEFLKELEAGEIREESRKRYALKAFEHTADYDAAISDFFRKQYAGDGLQYLPLRYGTNPHQKPASAFIAEGQLPFKVLCGSPGYINLLDALNSWPLVKELKKALGKPAAASFKHVSPAGAAIGLPLTAEERKVYMVDDIPGIETSALAQAYARARGADRMSSFGDMIALSDIVDVPTASIISKEVSDGVISPGYEPEALEILKKKKGGKYLVLQMDPEYEPGKTETRTVYGVTLQQGRNDYEITPETFKNVIVPKNSTLPESALRDLTVATIAVKYTQSNSVCYATRGQVVGLGAGQQSRIHCTRLAGDKADNWWLRFHPRVLGIKWKKGTKRPDKSNAIDLLVSGQLPKSGPERESFEALFEEVPAAFTEEEKTEWLSKLTDVVVSSDAFFPFTDNVYRASRTGVKYIAAPLGSQNDVPVIETAEKLGITFVEQNIRLFHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCP0</accession>
    <name>G0SCP0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-1,6-mannosyltransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0057910</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ANP1/MMN9/VAN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696111.1">
        <property type="nucleotide sequence ID" value="XM_006696048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCP0"/>
    <dbReference type="STRING" id="759272.G0SCP0"/>
    <dbReference type="GeneID" id="18259829"/>
    <dbReference type="KEGG" id="cthr:CTHT_0057910"/>
    <dbReference type="eggNOG" id="ENOG502QRPX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017872_4_0_1"/>
    <dbReference type="OMA" id="IPKTREG"/>
    <dbReference type="OrthoDB" id="2405412at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000017">
        <property type="entry name" value="Mannan polymerase II complex ANP1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052086">
        <property type="entry name" value="Mannan_Polymerase_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083:SF6">
        <property type="entry name" value="MANNAN POLYMERASE COMPLEXES SUBUNIT MNN9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083">
        <property type="entry name" value="MANNAN POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03452">
        <property type="entry name" value="Anp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS19166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="375" mass="42374" checksum="B546E6F350A7C3CB" modified="2011-10-19" version="1">MARSMGAVRLKKANPSTLAIGTLICVIILWFLVGSSGPDFSASRKAAAASHPLSPPTFPFRKSRSGSFKKPPPIAHYNLNNVTTTPHPAENRENVLILTPMTRFYQEYWDNLLRLSYPHELITLGFILPKTKEGNQATAALQKQVTKTQKYGPEKDRFKSIIILRQDFDPPLASQAEAERHKLENQKIRRAAMAKARNSLLFTTLGPLTSWVLWLDADVIETPPTLIQDLARTNESIIVPNCFQRFWNPEKNAMDERPYDFNNWQDSDTALEMAKKMGPDDILLEGYKELPTYRTLMAYLYDPAKYRFETIPLDGVGGTTLLVKAAVHRDGAMFPAFPFYHLIETEGFAKMAKRLGWQPVGMPHYKVGYATVARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0SD48</accession>
    <name>G0SD48_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipid binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0050800</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695423.1">
        <property type="nucleotide sequence ID" value="XM_006695360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SD48"/>
    <dbReference type="STRING" id="759272.G0SD48"/>
    <dbReference type="GeneID" id="18259118"/>
    <dbReference type="KEGG" id="cthr:CTHT_0050800"/>
    <dbReference type="eggNOG" id="ENOG502SIPH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013290_0_0_1"/>
    <dbReference type="OMA" id="PRYEDDT"/>
    <dbReference type="OrthoDB" id="5407957at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045967">
        <property type="entry name" value="HAM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138:SF4">
        <property type="entry name" value="DUF5923 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19343">
        <property type="entry name" value="HAM1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAM1-like N-terminal" evidence="2">
        <location>
            <begin position="26"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="HAM1-like N-terminal" evidence="2">
        <location>
            <begin position="243"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS18478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="746" mass="84403" checksum="6EC477724B28D08C" modified="2011-10-19" version="1">MFSCFGPGHRRRSDEHQPLLPQYDDETSLQRRVHQKLHSYQIVRALSKGFMPSSEQLVANLRTLLSSAILNPDAGSVSLSDSGQALVHCFKLCIKHLIDLLVHKNADDQIQEFIWYLTKAKLSADVEHLAERAMRAKTGADRAAVYSSLQTVASLLLTNSNFRLFLKDLNVIAREVFRDTAFAVSEASREAAERIKPSAEEQESLKQPYHDSHSNFSQHDVLEQTAELSRVFSGTASTVVGEAENSIVRKLSGPEKDTLVHRLKEAVLNLRQRPTYVDSVSTLSLLFKRYIVIYSRMARHTIEAASEDIDHNPEAEAALANFWGFLRSFGEPREWEELQNRARAIAEHGCEDPKFEELAIHIGNILQEMLTDPAFFDSIEQSFQELRDQSKQLTTHSSLREDVDALLLQVQSTLTSVVKDKDIANLAKTSAAIASILSPSGQYVNSDLVADALNVFIPLLVQSIHYIPIPRAEISTPKMDLLLENLILEPGVTINNTSFFPYKLRVKTLTDVEIHKTRFRTTSAIKTLVRLHIDGLSLRGEEIGFWLRVHSGLLRWADEGIASFALDERGMDVQLDVEVGRDRMDKILTLRGVRVRIHKLDWTLHRTRSSFGFISWLFKPFLKPIVRKMVEIRMASAIAQAFQFANRELLFARERLRATRIADPQDLKTFIKAVLARLTLPEDPDLHVRVGLTGSGQGVFEGVYTPGSIVKLWREEATQVSQRIREQQRDGWRNSIFDVQGAVPAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0SD82</accession>
    <name>G0SD82_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0059280</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696247.1">
        <property type="nucleotide sequence ID" value="XM_006696184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SD82"/>
    <dbReference type="STRING" id="759272.G0SD82"/>
    <dbReference type="GeneID" id="18259966"/>
    <dbReference type="KEGG" id="cthr:CTHT_0059280"/>
    <dbReference type="eggNOG" id="ENOG502S3PM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061001_0_0_1"/>
    <dbReference type="OMA" id="MIFREQE"/>
    <dbReference type="OrthoDB" id="5357075at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="328" mass="36990" checksum="35E88431063EAD9E" modified="2011-10-19" version="1">MAAIYATMHSPEELAALFSRNMTLDPMSQPRIMPDPIMIPDPVQQSLTPQPVQANPEPQPQQGRPIVYISQHYNHSAHVARQQQQQQQQQQTRPASEPPQNEFAEVERVLREHSVDTTRLSPAQLQLFKSVDTPQKLRLLDLWRTCPPTPNNNSSNGWGSTTMEIEEESARVRWEQQQAQQGQEEEKMETETEEVVMSLDGTPATAQPAQDVDGRWIVEMAQSYMEPYMAAGYEDLARSEYQISLSNNNGFSSADAGGMAQQVSSSSSSSSSSSSTDPSCATVIGDGDAMIFREQEKRRVDSVYRDMNMGRGEEWRRRCVGWRDVEMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDF1</accession>
    <name>G0SDF1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin-like fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0051560</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695497.1">
        <property type="nucleotide sequence ID" value="XM_006695434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDF1"/>
    <dbReference type="STRING" id="759272.G0SDF1"/>
    <dbReference type="GeneID" id="18259194"/>
    <dbReference type="KEGG" id="cthr:CTHT_0051560"/>
    <dbReference type="eggNOG" id="KOG3028">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055680_0_0_1"/>
    <dbReference type="OMA" id="FRNAWAS"/>
    <dbReference type="OrthoDB" id="198787at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF44">
        <property type="entry name" value="OUTER MEMBRANE PROTEIN (SAM35), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17172">
        <property type="entry name" value="GST_N_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like fold" evidence="1">
        <location>
            <begin position="71"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="338" mass="37818" checksum="0AC917930D0CFDC5" modified="2011-10-19" version="1">MTSQAPPYTQPWRKIPIPRPLQVLFDTFPLRTYEANGLPERAEHLTTSDLPTLYLFCTEEDARTGFPSYNPGCLKWQTLLRLAKIPFRTLPSTNHASPSGSLPFLLPPRTSSTSLTTPIPASHIPQYITEHSPPEHVLPSLPTPKNGPLRPEAYLPLLTLHLRNAWLAALYLTPAYSSLLEKLYLLPSSSNSLVRSSLKRQLRLAATEEIVSSLGRGTSGVAGEALEKMVEFEEIWHDAKQAMEGLCQVLRESEEGWFFGSEVPSEFDAAVFGYTQVMVEFMSSDSSFSSKKPEEVSQGDGKVLLGEMVKQAGNGELARHRERILARAWPEWDGKREW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDM4</accession>
    <name>G0SDM4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0052300</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695570.1">
        <property type="nucleotide sequence ID" value="XM_006695507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDM4"/>
    <dbReference type="STRING" id="759272.G0SDM4"/>
    <dbReference type="GeneID" id="18259268"/>
    <dbReference type="KEGG" id="cthr:CTHT_0052300"/>
    <dbReference type="eggNOG" id="ENOG502T0TG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_199238_0_0_1"/>
    <dbReference type="OMA" id="LIALWIH"/>
    <dbReference type="OrthoDB" id="5402816at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="75" mass="8442" checksum="9EC8C2FE4BFEAB41" modified="2011-10-19" version="1">MPAISNSIVVRDAVSHLAKRSNWAAREPGVVLVFCIVFIVGCLLIALWIHKFIKARRERRAQGGSQEMMADRHTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDN5</accession>
    <name>G0SDN5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CTHT_0052410</name>
    </gene>
    <organism evidence="23">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">ATP-dependent RNA helicase associated with the nuclear pore complex and essential for mRNA export from the nucleus. May participate in a terminal step of mRNA export through the removal of proteins that accompany mRNA through the nucleopore complex. May also be involved in early transcription.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Associates with the nuclear pore complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695581.1">
        <property type="nucleotide sequence ID" value="XM_006695518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDN5"/>
    <dbReference type="STRING" id="759272.G0SDN5"/>
    <dbReference type="GeneID" id="18259279"/>
    <dbReference type="KEGG" id="cthr:CTHT_0052410"/>
    <dbReference type="eggNOG" id="KOG0332">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_0_1"/>
    <dbReference type="OMA" id="IAAETRW"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17963">
        <property type="entry name" value="DEADc_DDX19_DDX25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000849">
        <property type="entry name" value="ATP-dependent RNA helicase DBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 17 22" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="11" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="4 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0811">Translocation</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="21">
        <location>
            <begin position="172"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="205"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="402"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="112"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="172"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EGS18636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="580" mass="64552" checksum="39F53A57A03F08F6" modified="2011-10-19" version="1">MRRSRRPTIRWCPVNSIRRAQTIWYPAEDLQRALATRTSPTIKDLELLVSGPSVCDSSLRNSPEKRNRASLNIRPSRQPDCGRLYFFVFDFSLPQLSTTDFETMADLASRITKPGDAPAADQPADAPQGNGNGNEVPVDDGANTGLVDSTYDVEVKLSDLQDTDNPLSSKISSFEELGLRKELNEGLLAMNFKKPSKIQERALPLMLANPPRNMIAQSQSGTGKTAAFVLTVLSRVDFTKPTQPQALLLAPSRELARQIQTVIQQIGQFIKDLVTEAAIPGNVSRETGVRASVVTGTPGTVTDLIRQRKFDVSQLKVLVIDEADNMLDKQGLGDQCVRVKMMLPKNIQILLFSATFPEKVMNYARKFAPNANEIKLRHQELTVKGISQMYMDCPDESKKYDILCQLYGLMTIGSSVIFVKTRESANEIQRRMEADGHKVSVLHGAHEGQNRDALLEDFRTGRSKVLITTNVLARGIDVSSVSMVINYDIPMKGPGDREPDCETYLHRIGRTGRFGRVGVSISFVYDRKSFEALSYIANYYGIDLIQLSPDDWDATEKKVQEVIKSARARPEYKPASEATC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-06-24" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDP9</accession>
    <accession>G3EQ77</accession>
    <name>NU152_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleoporin NUP152</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Nuclear pore protein NUP152</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">NUP152</name>
        <name type="ORF">CTHT_0052560</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 6">The nuclear pore complex (NPC) constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. The 55-60 MDa NPC is composed of at least 28 different subunits: AMO1, ELYS, GLE1, GLE2, MLP1, NDC1, NIC96, NSP1, NUP133, NUP145, NUP152, NUP159, NUP170, NUP188, NUP192, NUP37, NUP49, NUP53, NUP56, NUP57, NUP82, NUP84, NUP85, POM152, POM33, POM34, SEC13 and SEH1. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Nucleoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited. FG repeat types and their physico-chemical environment change across the NPC from the nucleoplasmic to the cytoplasmic side: FXFG repeats are especially abundant in NUPs on the nucleoplasmic side (in a highly charged environment and enriched in Ser and Thr).</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JF276304">
        <property type="protein sequence ID" value="AEN86180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695595.1">
        <property type="nucleotide sequence ID" value="XM_006695532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDP9"/>
    <dbReference type="SMR" id="G0SDP9"/>
    <dbReference type="STRING" id="759272.G0SDP9"/>
    <dbReference type="TCDB" id="1.I.1.1.2">
        <property type="family name" value="the nuclear pore complex (npc) family"/>
    </dbReference>
    <dbReference type="GeneID" id="18259294"/>
    <dbReference type="KEGG" id="cthr:CTHT_0052560"/>
    <dbReference type="eggNOG" id="KOG0845">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0866">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002780_0_0_1"/>
    <dbReference type="OMA" id="AFGNMFS"/>
    <dbReference type="OrthoDB" id="185618at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13170">
        <property type="entry name" value="RanBD_NUP50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053074">
        <property type="entry name" value="NPC_Nucleoporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38697">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SIMILAR TO S. CEREVISIAE NUP2 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38697:SF1">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SIMILAR TO S. CEREVISIAE NUP2 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0509">mRNA transport</keyword>
    <keyword id="KW-0906">Nuclear pore complex</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDV6</accession>
    <name>G0SDV6_CHATD</name>
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        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
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        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
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            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
    <sequence length="1006" mass="110910" checksum="01634653A5DCF38B" modified="2011-10-19" version="1">MNNEQFRQLLLSKSSNSSSSSKDGTSSTPSSSTARPLALGSKLRPSIPMTPRPGSTASARIDFAKQLAERNQAFEQQTQKQQMKFKASAPKGVKFAPGYVDRAKQRQEEEDERVRRIRALEESYKKGEIDRETYEKLQVEIAGGDLETTGLVKGLDYKLLERIRRGEDVWGGNKDKGKEEKEGGQEEEQPEDDADAILEQLESTEVKAITREKTQKKGQFATTGLVPGQKRTRNQILAEFKAQREAAKAKQQSSLGSRFKKIGEQKTPGTRIERDSKGREVLIIIDEDGHERRKVRKLDTQEEREEDERTRLEREKEREALASGKVLGMEVPEYYRRQQEEKKEEEEDGEINIFDDVGSDYDPLAELEGSGDESGEDKEEKKRKEPKETEKKEASEEPKAPPPPRNYFKDSKSELLSREEYKAPSLDDPAFLAALRKAKAAGLLEKKEEERKAAEREERLRKKLEELHRDDEDLDLGFGSSRLEDDADMEEGHVKLSAWDEDDDDDDDGAGGGGKKGKRKRGKKKMDKNKFEDVMKVIQQRKASAAKGWPFIPCKLVLYRWRFSVELRRRSGSNGSSGSSGSSGSNGSNGSPALRALSSWKGRIKVALLFHDTFAILLAAYHPAIRILGVSTVFGNASLEKTTNNALSILTAIHKADSIPVYIGSPHALTRPPLPAPTDIHGDSGLDGTSLLPKPKVSARTSPPAIDAAYAALKACKPGTAWVVATGAFTNIAKLFMTYPDLIGHIRGLSLMGGALGGGFTDAVLGVVDGVPRAGNWTQYAEFNVLADPEAAAFIFGNKELAAKTTLIPLDVSHLVLTTSTVRDLLLYGREGVEKRHPMGGSPSPTTPTPSPEGARLQGKTPLRTMLVELLLFFAKTYAEVFSITEGPPLHDPLAVAAVLTGLSETHPHLKEHEIPFIEHDPSITEPGLAQPERYEVSVVTEGSYEDALLRGARTGQIVAKKLPPGTPGVRIPRRLDVALFWEVLEECVQRADEAVARAEEGGKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDY1</accession>
    <name>G0SDY1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative mitochondrial phosphate carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0053410</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695677.1">
        <property type="nucleotide sequence ID" value="XM_006695614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDY1"/>
    <dbReference type="STRING" id="759272.G0SDY1"/>
    <dbReference type="GeneID" id="18259379"/>
    <dbReference type="KEGG" id="cthr:CTHT_0053410"/>
    <dbReference type="eggNOG" id="KOG0767">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039456_2_0_1"/>
    <dbReference type="OMA" id="YKGAIWL"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000131">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="67"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="165"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="268"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS18732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="389" mass="42717" checksum="EF7917BE01AC708C" modified="2011-10-19" version="1">MPLFPSIRAMKERLGRSSSNTSLPTRPIERGRTPNEARLNLYPACSISNTTTVVKPSPGHIKLYSGQYYAACTLGGLLACGLTHTLVTPLDLVKVRRQVDSSLYPSNIRGLRHIYRHELGLRGIFTGWVPTFFGYSAQGSFKYGWYEVFKKTYSDLAGPENAYRYKTGMYLAASASAEFLADIALCPFEAVKVRMQAGIPSPYKGMTDGLQTITTAEGVVGGLYKGLYPLWGRQIPYTMTKFASFETIVELIYEKGLPGKKSDYGKAAQTGVSFTAGYLAGILCALVSHPADVMVSKLNAYRKPEEGFGEVVRRIYKDIGFLGLWNGLGVRIVMIGTLTGLQWMIYVSAFLGGFERSHADSGQDYFKIFMGFPTTGGPAPPSKKEVAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0SE82</accession>
    <name>G0SE82_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA-binding protein rnp24-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0062810</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696590.1">
        <property type="nucleotide sequence ID" value="XM_006696527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SE82"/>
    <dbReference type="STRING" id="759272.G0SE82"/>
    <dbReference type="GeneID" id="18260319"/>
    <dbReference type="KEGG" id="cthr:CTHT_0062810"/>
    <dbReference type="eggNOG" id="KOG4210">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027451_1_1_1"/>
    <dbReference type="OMA" id="RVWVNQL"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12396">
        <property type="entry name" value="RRM1_Nop13p_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034225">
        <property type="entry name" value="Nop13/Rnp24_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF119">
        <property type="entry name" value="NUCLEAR RNA-BINDING PROTEIN SART-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="91"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="205"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="278"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="364"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="305"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="390"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS18259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="436" mass="49015" checksum="A1B59B5428C06411" modified="2011-10-19" version="1">MANKDDELIPQEEQHQATTTVKKRKSELAEIQVDLSAPEPPSKKARRLLKKGKKLPKKQSESGDENEEPAEDGKADGVADDKKKKKERSPYGVWIGNLPFSVTKADLRKWLVDNSGGVITEDLITRVHMPTNKPMAGSKRTFENKGFAYVDFATYEANTAAIALSETELNGRRLLIKDANNYEGRPKKEEPEAAVAKIPEGRSSTKIFVGNLAFNTTEDDLWAHFEKCGKIRWVKVATFEDSGKCKGYGWVMFEEPEAAQWAVKGFVKIRETVETVEDFMDGESKADGDGDTEMKDAKEDREEAGSEENAEDGDDETDSKPEKPKKKELKEPRTRIRKWWVNQLFGRNLKVELAEDDQTRYQKRFGKGAKKKQKQEVSKKSTKSDTNAASKEKGSKSKELKEKTTKQEPSYATDINVARLTGAVVAPQGKKVKFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEI6</accession>
    <name>G0SEI6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 16">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="2 16">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CTHT_0063880</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="16">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13 16">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="2 16"/>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696694.1">
        <property type="nucleotide sequence ID" value="XM_006696631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEI6"/>
    <dbReference type="STRING" id="759272.G0SEI6"/>
    <dbReference type="GeneID" id="18260426"/>
    <dbReference type="KEGG" id="cthr:CTHT_0063880"/>
    <dbReference type="eggNOG" id="KOG0660">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="OMA" id="MDIPRPE"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07857">
        <property type="entry name" value="STKc_MPK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000013">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000157">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008352">
        <property type="entry name" value="MAPK_HOG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01773">
        <property type="entry name" value="P38MAPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 16 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="23"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="380"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGS18363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="411" mass="46839" checksum="50C5C6C4202FABD1" modified="2011-10-19" version="1">MGELQGRKIFKVFNQDFIVDERYTVTKELGQGAYGIVCAAVNNQTGEGVAIKKVTNVFSKKILAKRALREIKLLQHFRGHRNITCLYDMDIPRPDNFNETYLYEELMECDLAAIIRSGQPLTDAHFQSFIYQILCGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENVGYMTEYVATRWYRAPEIMLSFQNYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILGTPNEETLSRIGSPRAQEYVRNLPYMAKKPFHTLFPNANPEALDLLDKMLAFDPSKRITVEEALAHPYLAIWHDPSDEPECPSVFNFDFEAVDDINEMRKMILDEVFRFRQLVRTAPGATGHGLQVNVQAVPVPMPQGPAQQWTADDPRPQEYTEMQGLEGELARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEP1</accession>
    <name>G0SEP1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0064440</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696749.1">
        <property type="nucleotide sequence ID" value="XM_006696686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEP1"/>
    <dbReference type="GeneID" id="18260482"/>
    <dbReference type="KEGG" id="cthr:CTHT_0064440"/>
    <dbReference type="eggNOG" id="ENOG502SNX3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009274_0_0_1"/>
    <dbReference type="OMA" id="QMSFRSI"/>
    <dbReference type="OrthoDB" id="5244050at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="596"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="673"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="706"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="706"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="770"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="795"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="829"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="868" mass="93221" checksum="0E08F59E24A90A6C" modified="2011-10-19" version="1">MGQPSKFPFSLPGRKHKTAGLTSPPPISAPLTKVQKILGTAAINIDSPTLLNPNRAPWDAQPSPGLGVVELGGEDQSQRHGHRGRWDDTSAASIDRPETSNSRHHAIESPGLTRRQSSSTITSHHENRSASAAASGLPSKAQALLDIDGTYTNNVPPPLNNDSHDRDMRKARKKPSKLDLSALLPGHKSSKNRDRDRDHRADSSRGHYPDNDATDSRSSTPPPILQRADRKIRKILTKESLRDRDRDKQTTPVPTSAPPAGPNRQYSANNELHNLYDHYEQRTFADAMDRQLQGLSAEYSIGSLDSVPEWRSTTETTATTATTATSASTSSLPPTTANNASSGKAFLSPFPQPVNVNVAASARAKMQQPVIPSSPIMPDCASVSSRHTRTSRASKRTERSLNEIDLLQNSVLALSSDSEDDFGGTSPRDSFSNTGDCIGPKTGAGLPVTGIEAGFARPAKRTSFLTSTQYLPSSHPSEVSATPTGPKILPRSSSLAAKKLMAKQLAGLVVTDNSRLSVGTASTDKTERIVVPEKDRKPKKIPSESDFNQFNFPTPPTTGSMNLPTRGRRSVSVSRALDHHVSQLLSPGMVVDMYLQSPYSPPPETDGPRSATSLGIRRGSESSSINDEGAISSNGRFMAVTRQEEMLLSALRMKRARMREDIIAELEEDAAAAASEKHDSVSSNGNGNGNGGQLRRQITNESIATSMMSRQSSWSTMRAAETVLSARPRQGSTGRIVLERRDTSGSRSGASSIVEGDEPTLGEHERRGSKSSTTSSRRNQSISSTRPARDGSLSRLGSDQTSTRGQQKGYISGRIPEEPVEEEVGVPRPDSPISPSPADFPVPNMTGSRGTGNGMKGNKQVRLSAVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>G0SF15</accession>
    <name>G0SF15_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0060450</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696362.1">
        <property type="nucleotide sequence ID" value="XM_006696299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SF15"/>
    <dbReference type="GeneID" id="18260083"/>
    <dbReference type="KEGG" id="cthr:CTHT_0060450"/>
    <dbReference type="eggNOG" id="ENOG502SJUN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007003_1_0_1"/>
    <dbReference type="OMA" id="QFRIIMN"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053187">
        <property type="entry name" value="Notoamide_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="67"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="229"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS18031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="782" mass="89859" checksum="3D5B9E65F14A058E" modified="2011-10-19" version="1">MSSTSRSTSPEISQQLNQPFRPLMPAPPGMARIVSPQQPAFSHLFAFQAQPTGSSSRRKQGKTITAACGACRKRKSKCDGTRPTCLVCREKGTPCEYDTNVSETHAQALKRKYQELQTQKAALEQVYSLLQTRPEEEARAVYRRIRLGEDPTSVLRHAQYGDVVMQHALEPQSNFRYEFPYLREMPPFLVWEGNPYLRAEIHDWEWRASVSGSEGSPLPQRQRALLLLPGTTTGTGDDVASPRSTSSGTSETLSAGSLTSDRREPYLKPYHTARVVHPWLDSVKPSMWTGVSDDDVLMRKLLHDYILFDWDWFTMFHKDYFLEDMAQGRRRFCSSLLVNAVLCMGSYCHRGLRSCAEHWNPKSFCYQFLAEARRLFDIDAEEERPVRLPDEQDADWHRRLVEWEQRRLCTIQAAILINLIQNINGADKIGWRVTVRALELAREIKLFDEPPEYYGPEMVIVRTYTAWACYCWQSLSTFFYLRPPLIKDPPKALLPDPIENPQWYGELWIAYPGSTHRFPTYHGLSFKAKCEFWRIITEIGSIMFAGDRSPIVMPLKQTLHYVNRLRDWLHGLPEPLSPSKIVFPQHLKLHLGYYYMLIEVISPIIGCTEVDGVPLNPTPYDLYLEAVNCHETLIRIHYLRHGFEGFDTFMLHFLGFNNHLAIRAVETSQGSSYLEPRRSSVILFAKGIHEFSQALFIAKAILKLQVGRMQASEAELLRRELEIEPEEVAYGPMEQTVQSDWPEYDVGVEAKAERVKEGKTLATSLAELSLLERERKSASPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>G0SF35</accession>
    <name>G0SF35_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0060660</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696382.1">
        <property type="nucleotide sequence ID" value="XM_006696319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SF35"/>
    <dbReference type="GeneID" id="18260104"/>
    <dbReference type="KEGG" id="cthr:CTHT_0060660"/>
    <dbReference type="HOGENOM" id="CLU_915275_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="304" mass="32096" checksum="65A5A407175772FD" modified="2011-10-19" version="1">MIGKQANRVSQQQKQQQLQAADAGRTESMGPGRAAGEGEPSDGRQEMHLSAAHCDGDLGRGLGVTGDCRMQTGAFCCFPNPELPAREDQMGSMETGDAAASPGLGRWIELDGLSAAAAGRDLMRAPAQQAEETGRDRQKQQRPVESSTSAGKQGKRSPANVTVKWSTRHSRTRGKAHRTSGAAGATAEGHQDHGGTPLIPHRYAGREDGDGLRLELERPREKEGKALTDEVEHALPATRAVREPAAAFYLYVGRNGVDGAQSTPAALFAAVQSFKSSSAISPQPQVAVPAVTVGLKHPLPNQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0SF49</accession>
    <name>G0SF49_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative clathrin binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0060800</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696396.1">
        <property type="nucleotide sequence ID" value="XM_006696333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SF49"/>
    <dbReference type="STRING" id="759272.G0SF49"/>
    <dbReference type="GeneID" id="18260118"/>
    <dbReference type="KEGG" id="cthr:CTHT_0060800"/>
    <dbReference type="eggNOG" id="KOG0251">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014248_1_0_1"/>
    <dbReference type="OMA" id="AWTIVFK"/>
    <dbReference type="OrthoDB" id="44015at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005545">
        <property type="term" value="F:1-phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16988">
        <property type="entry name" value="ANTH_N_YAP180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.150:FF:000004">
        <property type="entry name" value="ENTH domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000025">
        <property type="entry name" value="ENTH domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.150">
        <property type="entry name" value="ANTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014712">
        <property type="entry name" value="ANTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045192">
        <property type="entry name" value="AP180-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951">
        <property type="entry name" value="CLATHRIN ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951:SF5">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-BINDING CLATHRIN ASSEMBLY PROTEIN LAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="4">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="276"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="490"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="490"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="518"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="554"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="567"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS18065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="644" mass="71109" checksum="5D5A1984C42427E5" modified="2011-10-19" version="1">MASSFEKSVKGATKIKLAPPKTKYIEHILVATHSGEAGVGEVFRALQYRLRDSAWTVVFKSLITVHLMIREGSPDVTLAYLAKHRNLLAVSVFSDAQTQGRNIRHYANYLSERARAFRETKIDWVRMREPRLEKLPVEKGLLRETEIVQNQVTALLKCDVMDNEPENEITITVFRLLVLDLLALFQALNQGLINILGHFFELSKPDAERALEIYRTFAKQTDYVVQYLSVARQYEHHTRVEVPKLKHAPVNLGRQLEEYLRDPDFEIHRRQYLAEQEAKKKGLSSKAKTSSSTNTKSTATQSSDSTSKPEASKGPDADLIDFFESIEQNQTTMVVQAQPVQTQPQPQPQPQPQVQMSMGMSPWGPTPFQTQPVAQVAQVQPNAFMAQPTGFQTGIGLQQQAQTPFSMPQQTPQQLNPSFTGAGFGGFTAQAQPQAAFQPTTLAPIPQDSMATFQTQTTVPTTTAPTFQTGLQAPQSTNPFRQSMLMAQQTGSPFTSTPASVNQQRPTTSPSTNPFARTSPQTSTQPFTTPVSSSPFQQTTTTTAAPMQQPLPTGSTNPFAKNFTGSQATQQAQQQQHVQQRPVTAGGILSQPTGSTNPFRQGAFVNHTTGLGWQHSQQPIGGGLDQLETIPVFPRPAAQTPWQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFE6</accession>
    <name>G0SFE6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0061770</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696493.1">
        <property type="nucleotide sequence ID" value="XM_006696430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFE6"/>
    <dbReference type="STRING" id="759272.G0SFE6"/>
    <dbReference type="GeneID" id="18260215"/>
    <dbReference type="KEGG" id="cthr:CTHT_0061770"/>
    <dbReference type="eggNOG" id="ENOG502RNGF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_469285_0_0_1"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03194">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="335"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="581" mass="65988" checksum="D513CBE8108A78F5" modified="2011-10-19" version="1">MEQTQSSTGTHLTLLAPPQEVLTLIVSQLCLHCHERERGRIIPYTYLERECDFNKPELSTWYYLNRLALYNLCLVSRQCRSIAEPILYHEFPPFWAFYPSPSAYPDWADRLAMFLRTVGLDSAKAAYVRRVCIHSNRMRCGGDLELAALAVREVFQARGIQLGPVYDAIAKRELELSDFGVRPGSRPPDGPKLEMGVLLLLAVLPNLTSLVLPNGFPSIGIPSQAIRLLGREQLVLQSYEVRASRPGGFLRYPLNVLEMASETLTSLTLDYPLDLSLRLIEPVPLPNLRHLYLLNSSIGHQNLKGVDHWLFKLKGLETFDYESAGSCLHNIAAKMVYRLYITNKNYSSWSLRVWLLMRQLDIPFIEEFRPMISGTFSQPQWKEFSPVARVPCLHVLPDNPHTDSEPLILWDSLSITTFLSLSHPEKPIYPSSPQALAWSLSAVAEMHSSFTSLRDHLAMNIGVRVQLSYPLPAGVVNDLQRLNTLWTEGLTRFGGPWLVGKEFSAVDAFYAPVALRLRTYVGLEEEFFSREAKGWVERVLGLESVREWVRDAVGERLREEVHDKESMGGEGRRVLDDLRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFH6</accession>
    <name>G0SFH6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Multifunctional tryptophan biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="16">Anthranilate synthase component 2</fullName>
                <shortName evidence="16">AS</shortName>
                <ecNumber evidence="16">4.1.3.27</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="16">Anthranilate synthase, glutamine amidotransferase component</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">Indole-3-glycerol phosphate synthase</fullName>
                <shortName evidence="16">IGPS</shortName>
                <ecNumber evidence="16">4.1.1.48</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
                <shortName evidence="16">PRAI</shortName>
                <ecNumber evidence="16">5.3.1.24</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CTHT_0070860</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 16">Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 16">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="16"/>
    <dbReference type="EC" id="4.1.1.48" evidence="16"/>
    <dbReference type="EC" id="5.3.1.24" evidence="16"/>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697359.1">
        <property type="nucleotide sequence ID" value="XM_006697296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFH6"/>
    <dbReference type="STRING" id="759272.G0SFH6"/>
    <dbReference type="MEROPS" id="C26.959"/>
    <dbReference type="GeneID" id="18261124"/>
    <dbReference type="KEGG" id="cthr:CTHT_0070860"/>
    <dbReference type="eggNOG" id="KOG0026">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4201">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007713_2_0_1"/>
    <dbReference type="OMA" id="EPIEWAN"/>
    <dbReference type="OrthoDB" id="524799at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000136">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000031">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050472">
        <property type="entry name" value="Anth_synth/Amidotransfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016302">
        <property type="entry name" value="Anthranilate_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418:SF4">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001382">
        <property type="entry name" value="TrpG-trpC-trpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 16" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 16" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="18">
        <location>
            <begin position="26"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Indole-3-glycerol phosphate synthase" evidence="19">
        <location>
            <begin position="247"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="N-(5'phosphoribosyl) anthranilate isomerase (PRAI)" evidence="20">
        <location>
            <begin position="598"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="582"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="590"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR001382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EGS17741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="775" mass="83918" checksum="753EDA1F642EE16F" modified="2011-10-19" version="1">MAAPLVDYSRDANPSPLVPTASNLILIDNYDSFTWNVYQYLVLEGAKVTVFRNDKITLDELIAKKPTQLVISPGPGHPKTDSGISRDAIRHFAGKIPIFGVCMGQQCIIDLYGGDVSYAGEILHGKTSPLTHDGRGVYAGLEQGLPVTRYHSLAGTHVTLPECLEVTSWIAKEDGSKGVIMGVRHKEYTIEGVQFHPESILSAEGRTMLRNFLHMQGGTWAENERLQKQKAAPKPAPSAGSGSSNILQRIYAARRTAVSAQKQLPSQRPSDLQAAYRLGLAPPQISFPDRLRQSPFPVSLMAEIKRASPSKGVFALDIDAPSQARKYALAGASVISVLTEPEWFKGSIEDLRAVRRVLDGMPNRPAVLRKEFVFDEYQILEARLAGADTVLLIVKMLEPELLKRLYDYSLSLGMEPLVEVQNAEEMTVAINLGAKVIGVNNRNLENFEVDLGTTGRLRSMVPEGTILCALSGINSHQDVLDCKHDGVNAVLVGEAIMRAPDASTFIRDLCAGPEQDDAQQKQESAPPLLVKICGTRSAAAATEAIRAGADLVGMILVPGTKRCVSHDTALAISAAVHSARLARSPPVAPNPSSEGSKQTQAQDWFTHTAATLREMVKTRGPLLVGVFMNQPLSDILTAVRVYDLDIVQLHGNEPLEWARLIPVPVIRKFTPSKDSSQTDLLRVRGYHVLPLLDSGAGSGRLLDLDGVRQVLREEEGVQIMLAGGLDEGNVAEVVRGLGELGTRVVAVDVSSGVEVGGEQSVERVREFIKAAKGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFL4</accession>
    <name>G0SFL4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0071260</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697397.1">
        <property type="nucleotide sequence ID" value="XM_006697334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFL4"/>
    <dbReference type="GeneID" id="18261164"/>
    <dbReference type="KEGG" id="cthr:CTHT_0071260"/>
    <dbReference type="HOGENOM" id="CLU_1815584_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="142" mass="15494" checksum="D98749D16FA5157D" modified="2011-10-19" version="1">MIDAVNSQRAAATASDLADEVRSQVTGQAVEAHRLSEIGPAPETPDQRLTRQGGMWWRWSESFTSRCESSLAAAGAKSLTPNLSPSPGPRSGQDHVPRRLHPRTIAVIPHYRHAGILILVFAVGRIPEDVDQHERPIFVSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFX7</accession>
    <name>G0SFX7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative cell wall protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0072510</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Dual chitinase/transglycosylase that plays a role in cell wall architecture. Chitinase and transglycosylase activities are coupled. Required for the polysaccharide cross-linking at the septa and the cell wall. More specifically, transfers chitin to 1,6-beta-glucan in the cell wall.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697510.1">
        <property type="nucleotide sequence ID" value="XM_006697447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFX7"/>
    <dbReference type="STRING" id="759272.G0SFX7"/>
    <dbReference type="GeneID" id="18261289"/>
    <dbReference type="KEGG" id="cthr:CTHT_0072510"/>
    <dbReference type="eggNOG" id="ENOG502QVQI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040459_0_0_1"/>
    <dbReference type="OMA" id="WNATANQ"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000159">
        <property type="entry name" value="Glycosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF22">
        <property type="entry name" value="GLYCOSIDASE CRH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409149" evidence="7">
        <location>
            <begin position="20"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="8">
        <location>
            <begin position="88"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="375"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00093308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS17892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="445" mass="47356" checksum="FF233435DFADEB74" modified="2011-10-19" version="1">MVRTSVLGAALLGAASVLAVDPPSCSLDKKCPKEMPCCSQYGQCGVGAYCLGGCDPRMSYSLDSCLPAPVCKDKVYKMDSLDRYKDISEYLGDPKTADWVGQGEPLIYQGNTLLTMPPKSVGTVLATTTYMWYGSVRARLKTSRGRGVVTAFILYSDVKDEIDFEWVGVDLGTVQTNYYFQGIPNYTNTGNISISSNSYEDFHDYEIQWTPDEIRWLVDGKVGRVKKRSETWNATANQWDFPQTPARVQISIWPGGLETNAEGTINWAGGKIDWESDEIKNYGYYFATFAEVEVKCYRTDSPPGTNKGISYYYTDYRATNDTVVDGNKSTVIKSLLATGLDPTKGDPAKASKSGSASAAESSVFAIPGGGVGIGNPVPGSSSGSDGSSGSGTGTGRSSFCDGSSFSQDCTGGSDAGENAGVRGVRSGLGASAFAVVVGIAGLLFL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2024-05-29" modified="2025-04-09" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGC7</accession>
    <name>MGM1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dynamin-like GTPase MGM1, mitochondrial</fullName>
            <ecNumber evidence="7">3.6.5.5</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="9">Dynamin-like GTPase MGM1, long form</fullName>
                <shortName>l-MGM1</shortName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="9">Dynamin-like GTPase MGM1, small form</fullName>
                <shortName>s-MGM1</shortName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="8" type="primary">MGM1</name>
        <name evidence="11" type="ORF">CTHT_0065850</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="13 14 15" key="2">
        <citation type="journal article" date="2019" name="Nature" volume="571" first="429" last="433">
            <title>Structure and assembly of the mitochondrial membrane remodelling GTPase Mgm1.</title>
            <authorList>
                <person name="Faelber K."/>
                <person name="Dietrich L."/>
                <person name="Noel J.K."/>
                <person name="Wollweber F."/>
                <person name="Pfitzner A.K."/>
                <person name="Muhleip A."/>
                <person name="Sanchez R."/>
                <person name="Kudryashev M."/>
                <person name="Chiaruttini N."/>
                <person name="Lilie H."/>
                <person name="Schlegel J."/>
                <person name="Rosenbaum E."/>
                <person name="Hessenberger M."/>
                <person name="Matthaeus C."/>
                <person name="Kunz S."/>
                <person name="von der Malsburg A."/>
                <person name="Noe F."/>
                <person name="Roux A."/>
                <person name="van der Laan M."/>
                <person name="Kuhlbrandt W."/>
                <person name="Daumke O."/>
            </authorList>
            <dbReference type="PubMed" id="31292547"/>
            <dbReference type="DOI" id="10.1038/s41586-019-1372-3"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (3.60 ANGSTROMS)</scope>
        <scope>FUNCTION</scope>
        <scope>SUBUNIT</scope>
        <scope>DISULFIDE BONDS</scope>
        <scope>MUTAGENESIS OF ASP-559; LYS-562 AND PHE-840</scope>
    </reference>
    <comment type="function">
        <text evidence="1 2 7">Dynamin-related GTPase that is essential for normal mitochondrial morphology by mediating fusion of the mitochondrial inner membranes, regulating cristae morphology and maintaining respiratory chain function (PubMed:31292547). Exists in two forms: the transmembrane, long form (Dynamin-like GTPase MGM1, long form; L-MGM1), which is tethered to the inner mitochondrial membrane, and the short soluble form (Dynamin-like GTPase MGM1, short form; S-MGM1), which results from proteolytic cleavage and localizes in the intermembrane space (By similarity). Both forms (L-MGM1 and S-MGM1) cooperate to catalyze the fusion of the mitochondrial inner membrane (By similarity). The equilibrium between L-MGM1 and S-MGM1 is essential: excess levels of S-MGM1, following loss of mitochondrial membrane potential, lead to an impaired equilibrium between L-MGM1 and S-MGM1, inhibiting mitochondrial fusion (By similarity). Plays a role in the maintenance and remodeling of mitochondrial cristae, some invaginations of the mitochondrial inner membrane that provide an increase in the surface area (PubMed:31292547). Probably acts by forming helical filaments at the inside of inner membrane tubes with the shape and dimensions of crista junctions (PubMed:31292547).</text>
    </comment>
    <comment type="function">
        <molecule>Dynamin-like GTPase MGM1, long form</molecule>
        <text evidence="1 2 7">Constitutes the transmembrane long form (L-MGM1) that plays a central role in mitochondrial inner membrane fusion and cristae morphology (By similarity). L-MGM1 and the soluble short form (S-MGM1) form higher-order helical assemblies that coordinate the fusion of mitochondrial inner membranes (By similarity). Inner membrane-anchored L-MGM1 molecules initiate membrane remodeling by recruiting soluble S-MGM1 to rapidly polymerize into a flexible cylindrical scaffold encaging the mitochondrial inner membrane (By similarity). Once at the membrane surface, the formation of S-MGM1 helices induce bilayer curvature (By similarity). MGM1 dimerization through the paddle region, which inserts into cardiolipin-containing membrane, promotes GTP hydrolysis and the helical assembly of a flexible MGM1 lattice on the membrane, which drives membrane curvature and mitochondrial fusion (PubMed:31292547).</text>
    </comment>
    <comment type="function">
        <molecule>Dynamin-like GTPase MGM1, small form</molecule>
        <text evidence="1 2 7">Constitutes the soluble short form (S-MGM1) generated by cleavage by PCP1, which plays a central role in mitochondrial inner membrane fusion and cristae morphology (By similarity). The transmembrane long form (L-MGM1) and the S-MGM1 form higher-order helical assemblies that coordinate the fusion of mitochondrial inner membranes (By similarity). Inner membrane-anchored L-MGM1 molecules initiate membrane remodeling by recruiting soluble S-MGM1 to rapidly polymerize into a flexible cylindrical scaffold encaging the mitochondrial inner membrane (By similarity). Once at the membrane surface, the formation of S-MGM1 helices induce bilayer curvature (By similarity). MGM1 dimerization through the paddle region, which inserts into cardiolipin-containing membrane, promotes GTP hydrolysis and the helical assembly of a flexible MGM1 lattice on the membrane, which drives membrane curvature and mitochondrial fusion (PubMed:31292547). Excess levels of S-MGM1 produced by cleavage by PCP1 following stress conditions that induce loss of mitochondrial membrane potential, lead to an impaired equilibrium between L-MGM1 and S-MGM1, thereby inhibiting mitochondrial fusion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Oligomeric complex consisting of membrane-bound and soluble forms of MGM1.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Dynamin-like GTPase MGM1, long form</molecule>
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
            <orientation evidence="2">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="subcellular location">
        <molecule>Dynamin-like GTPase MGM1, small form</molecule>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The paddle region plays a major role in driving mitochondrial inner membrane fusion (PubMed:31292547). It binds lipid membranes enriched in negatively charged phospholipids, such as cardiolipin, and promotes membrane tubulation (PubMed:31292547). MGM1 dimerization through the paddle domain promotes the helical assembly of a flexible MGM1 lattice on the membrane, driving mitochondrial fusion in cells (PubMed:31292547).</text>
    </comment>
    <comment type="PTM">
        <text evidence="2">Cleavage of the transit peptide by mitochondrial processing protease (MPP) produces a long integral membrane form of MGM1 (L-MGM1) (By similarity). Further processing by the rhomboid protease PCP1 produces a short peripheral membrane form of MGM1 (S-MGM1) (By similarity). Both forms are required for full activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="term" value="F:GTP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
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        <property type="term" value="F:GTPase-dependent fusogenic activity"/>
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        <property type="term" value="F:lipid binding"/>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="term" value="P:receptor internalization"/>
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    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Putative mitochondrial dynamin GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Dynamin"/>
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        <property type="entry name" value="Dynamin_GTPase"/>
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        <property type="entry name" value="Dynamin_GTPase_CS"/>
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        <property type="entry name" value="Dynamin_stalk"/>
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        <property type="entry name" value="G_DYNAMIN_dom"/>
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        <property type="entry name" value="GED_dom"/>
    </dbReference>
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        <property type="entry name" value="LIS_MGM1"/>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="LIS_MGM1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
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        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0446">Lipid-binding</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000460452" description="Dynamin-like GTPase MGM1, long form" evidence="9">
        <location>
            <begin position="28"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000460453" description="Dynamin-like GTPase MGM1, small form" evidence="2">
        <location>
            <begin position="190"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Dynamin-type G" evidence="5">
        <location>
            <begin position="249"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="4">
        <location>
            <begin position="815"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1 motif" evidence="5">
        <location>
            <begin position="259"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2 motif" evidence="5">
        <location>
            <begin position="285"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3 motif" evidence="5">
        <location>
            <begin position="359"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4 motif" evidence="5">
        <location>
            <begin position="427"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5 motif" evidence="5">
        <location>
            <begin position="456"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Stalk region" evidence="10">
        <location>
            <begin position="549"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Paddle region" evidence="10">
        <location>
            <begin position="710"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Stalk region" evidence="10">
        <location>
            <begin position="810"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="13 14 15">
        <location>
            <begin position="812"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Impaired mitochondrial morphology." evidence="7">
        <original>D</original>
        <variation>A</variation>
        <location>
            <position position="559"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Impaired mitochondrial morphology." evidence="7">
        <original>K</original>
        <variation>A</variation>
        <location>
            <position position="562"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Abolished GTPase activity." evidence="7">
        <original>F</original>
        <variation>D</variation>
        <location>
            <position position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="O60313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P32266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="31292547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="8">
        <source>
            <dbReference type="PubMed" id="31292547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="9"/>
    <evidence type="ECO:0000305" key="10">
        <source>
            <dbReference type="PubMed" id="31292547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="EMBL" id="EGS17266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="13">
        <source>
            <dbReference type="PDB" id="6QL4"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="14">
        <source>
            <dbReference type="PDB" id="6RZT"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="15">
        <source>
            <dbReference type="PDB" id="6RZU"/>
        </source>
    </evidence>
    <sequence length="939" mass="103185" checksum="5897D0A47FACE393" modified="2011-10-19" version="1" precursor="true">MSAQLRAAAAITPAARRVISGPAAVRRFHHYHHLPTGGIQRVEIAARGLRRSVQFPALANAYHNNAVIVRNASFTRLLPKLALKFIRVPALFGGMMLGAVGWVQYQAIKVSNSAQEFYGNIKATVADTAFSVWSSAVDIAEQTKRGWENTKNQFEIPEWLDRIMKGEGLAGEGSGSGEGGPNGGPEPPRQSRAGAATVAGASATVYGYGASDNDDRTPEEIMRDDNMMFITKKMIEIRNLLQKVGQGSTVTLPSIVVIGSQSSGKSSVLEAIVGHEFLPKGSNMITRRPIELTLVNDPEAKVDYGEFPDLGLARVTDFSLIQKTLTELNQSVPESECVTDDPIRLTIHSPNIPDLSLIDLPGYIQVAGENQPRELKRKITELCDKYIRGPNIILAISAADTDLANSTALQASRRVDPRGERTIGVITKMDLVEPEKGAAILSDRQYPLKLGYVGVISKLPPQSGLFRRDTGNLLASINRNEKNYFGSHPTEFGPDSGVSTGVMTLRKKLLQVLEQQMSSKLNETTEAIQRELEETTYQFKVQYNEQPMSAESYLAASLDDFKHQFHEFASSFGRPQLQTLLKDALDQKVLDQLAARYWNRPIEDLSPAPREPDNIIDLPKADPDSPYWHRQLDTACSGLTRLGVGRLAATVAASAIQQHVEKLLDKSSFAKHPSARKVISDAAATVLADRSYATSDGIEISLKPYKFDPDIQPNEWAQGREHVVGVLQAELEQCQAAMKALENSVGGRKKLKEVMSFVDKARKGEIIVEGDHPSGAGGFSAALLARGREAVFLRDRADILSLRIQAAKSRQCKTLTNKYYCPEVFLDAVATKLAQTAVLFLNVEMLNDFYVRFPREVEAKLHEHMHAGGGLEKFAREDPKVRRHLDLIRRKELLETVLGKIEELHRISSGTAGTLGLRGAGDLKKRIGAPSSSGRRSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGE5</accession>
    <name>G0SGE5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0066040</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696902.1">
        <property type="nucleotide sequence ID" value="XM_006696839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGE5"/>
    <dbReference type="STRING" id="759272.G0SGE5"/>
    <dbReference type="GeneID" id="18260642"/>
    <dbReference type="KEGG" id="cthr:CTHT_0066040"/>
    <dbReference type="eggNOG" id="KOG0241">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001485_2_3_1"/>
    <dbReference type="OMA" id="NDEMESP"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01365">
        <property type="entry name" value="KISc_KIF1A_KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000050">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="7">
        <location>
            <begin position="93"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="48"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="558"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="632"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="491"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="576"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="649"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="197"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS17284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="698" mass="78636" checksum="022A5E712EE517D8" modified="2011-10-19" version="1">MYSNHQLRFRDVVNDINETLIGISPYPRLMPNNAGCLPYAARHSYHYSDGGGSRAASSASSSRPMHAPPVRSTASSAPLRSLDGTLPSSIGGNVKVVVRVRAFLPREIERGAECLVEMDPVTNRTTLKPPNGYDPANVRAHSRKVIENKSFTFDKSFWSHNPADPRYATQEDIYDCLGEEFLDHNFEGYHTCIFAYGQTGSGKSYTMMGTPENPGLIPRTCEDLFQRIAVASQESPNVTYHVRVSYFEVYNEHVRDLLVPVVPGQPPYYLKIRESPTEGPYVKDLTEVPVRSLDEILRYMRMGDANRTTASTKMNDTSSRSHAVFTIMLKQIHHDLETDETTERSSRIRLVDLAGSERAKATEATGQRLREGSNINKSLTTLGRVIAALADPKRSRHGHRDKVVPYRDSILTWLLKDSLGGNSKTAMIACISPSDYEETLSTLRYADQAKRIRTRAVVNQRENISSAQRDAQIAAMAEEIRQLQLIVGDSRRRFEKDSREAEEKLEEYQARVRNLQELMEERTLVAEGKIRSLQTENEALRMHLRLAVEALKNPIRVPAGGVQNEEQNNKNKEAAEGTEEVEDDGYASGEPGSPAGEYAEDYEPENGAHDMQERMQGLLRDLDLFRRKIGDDKSRFLMSQPTPPPSSHSDSEDACQEKDASEDRTPNWWEVAALDERISELLNRPRPWLTARGRKNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGG4</accession>
    <name>G0SGG4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N-terminal acetyltransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0066240</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Commun. Biol." volume="4" first="2" last="2">
            <title>Structural basis of Naa20 activity towards a canonical NatB substrate.</title>
            <authorList>
                <person name="Layer D."/>
                <person name="Kopp J."/>
                <person name="Fontanillo M."/>
                <person name="Kohn M."/>
                <person name="Lapouge K."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="33398031"/>
            <dbReference type="DOI" id="10.1038/s42003-020-01546-4"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.57 ANGSTROMS) OF 1-190</scope>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696921.1">
        <property type="nucleotide sequence ID" value="XM_006696858.1"/>
    </dbReference>
    <dbReference type="PDB" id="6ZMP">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.57 A"/>
        <property type="chains" value="A/B=1-190"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGG4"/>
    <dbReference type="SMR" id="G0SGG4"/>
    <dbReference type="STRING" id="759272.G0SGG4"/>
    <dbReference type="GeneID" id="18260662"/>
    <dbReference type="KEGG" id="cthr:CTHT_0066240"/>
    <dbReference type="eggNOG" id="KOG3234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_7_1_1"/>
    <dbReference type="OMA" id="EQHPSMR"/>
    <dbReference type="OrthoDB" id="10264728at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000058">
        <property type="entry name" value="N-acetyltransferase (Nat5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051646">
        <property type="entry name" value="NatB_acetyltransferase_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS17303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="6ZMP"/>
        </source>
    </evidence>
    <sequence length="235" mass="27244" checksum="42FA9B2B92EDF953" modified="2011-10-19" version="1">MVTVRRFRPEDLNKLAKCNLDPFTETYELGFYLQYYAKWPSLFQVAEDQHGNIIGYIMGKLESSPDVYRFSPHYLPWHAHITAVTVAPEARRMGIGRLLTEQLEAAADAADAWFVDLFVRTTNHKAIAFYKSMGYSVYRVVKDYYGDHSADPSRSSEDAYDMRKPMKRDVKREHIREDGEKHEVDPSVVCLAANTFRLAIDICEYTLIDMWLDVIYGTLDITDLLHLTCTEQHFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGH1</accession>
    <name>G0SGH1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CDC20/Fizzy WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0066310</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696928.1">
        <property type="nucleotide sequence ID" value="XM_006696865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGH1"/>
    <dbReference type="STRING" id="759272.G0SGH1"/>
    <dbReference type="GeneID" id="18260669"/>
    <dbReference type="KEGG" id="cthr:CTHT_0066310"/>
    <dbReference type="eggNOG" id="KOG0305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014831_4_0_1"/>
    <dbReference type="OMA" id="WSKNTDE"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF1">
        <property type="entry name" value="FIZZY-RELATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="7">
        <location>
            <begin position="307"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="351"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="434"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="564"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="128"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS17310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="618" mass="68799" checksum="789052352FC7326D" modified="2011-10-19" version="1">MGSNHPAPGGSSVSRSSARRASVSAAPGNSHAYPAYSDNCHHSHARPEPSRQRHREQTPDMPPEAILQRRAEALARQTRIPRSPSPAVPPLSPRPPKIRGESSSKALLNATPATELEDAVANVSRRVVGRQVTPGASPHRKRQRITGDRFIPTRSGRDLSSGFRLLQPPTDPATPSRQKGRTPQKELSQKTQEANQAFFHVLRHEMFDDTVPVISPVSDQGPYTPPKVPAQPRPSMYTPSTPQKNLFVYNSPYHLTPSGTPQSRESRNFDVTSEGYNLTPFRYSTQRMLLAPRRMQRVVSKVPFKVLDAPGLVDDFYLNLLDWGGTNILAVGLDSSVFMYNAQTSKASRLCTLEDDKITSVSWIENGNHLAIGTKKGLVQIWDAARCKRLRTMTGHTGRVGSLAWNAHILSTGSRDRHIYHRDVRAPDQWLRRLVGHKQEVCGLKWNTQTNQLASGSNDNLVMVWDKLSEEPLWMFSQHKAAVKALAWSPHQRGLLASGGGTADRRIIFHDTVRGIVKNDIDTGSQVCNIMWSKNSNEIVSTHGYSQNQLVIWKYPSMTQVASLTGHTYRVLYLAMSPDGRSVVTGAGDETLRFWEVFNKRVVHKLDGSDGIQMPVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGI8</accession>
    <name>G0SGI8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">75k gamma secalin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0066480</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SCC4/mau-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696945.1">
        <property type="nucleotide sequence ID" value="XM_006696882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGI8"/>
    <dbReference type="GeneID" id="18260686"/>
    <dbReference type="KEGG" id="cthr:CTHT_0066480"/>
    <dbReference type="eggNOG" id="ENOG502SEKM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006541_0_1_1"/>
    <dbReference type="OMA" id="QMVDICC"/>
    <dbReference type="OrthoDB" id="5565328at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019440">
        <property type="entry name" value="MAU2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21394">
        <property type="entry name" value="MAU2 CHROMATID COHESION FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10345">
        <property type="entry name" value="Cohesin_load"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="232"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="328"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="473"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="485"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="520"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS17327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1174" mass="131096" checksum="DD83C1BBD4CA4BE4" modified="2011-10-19" version="1">MELAEAVEPMETSVGVRSRRSTDGPLLHPTSFITPGPTSPSCRVVHGSDCAGQINHKTTQEDLHRSVWPATGSTMPPGDVFASEGQQFQFPYPRPQQQHHQQPSRQVQAHPYLHPQQVQTQQQQQPQTPHHLLPPLSPSPQVSQHPALYANARVNGNQQAYQHQQHVRYVHPAFVTGQQPLATQFYANNAPQQNQHQTQQQQYSNFNAGFHQPQPLHPQTWQLPPLQHIQVPPAAQVAASSPTASSMHFLNSPYAQQSPDSRPLAHNFPTSQPTAMSPQLPRVTPSQPLPQPQAQYQSQPRPQPQTHLQSQIHQSPIQARPPLQSHIQPQPQLQSPAQILPQQQSQPLPQLQQTKSQLQVLPSPQLQQQPRPQPASQPQARPQLQSPIQIQPQQQPQPVGQPQPAFQPVRQQSRQQPQQQVRLQVQQTPRQPQPQIQQQSSIQSQPKAHQHHAQQQTQHNQVRQSQPRPPVQQPQARQPQQPQQPQQPQPQPQPQPQIQQQTPTAKASPIVSARQSQESQTREQAEDQRRLSATAGVSKSPASVLAPADTLPLLILVAEDCFEKANVAAQQVARSMTEGEVAEHHKLVATGLGCLEVALKSRKLWPRLEARLMLRYASVLVEETTNIEKAETVLSKGISLCEKHRFLDLKYNTIWLHMKVLFQRNQKAALISIENHIADCTSYKHLPWIYAFRFLKAAFHLQSTTGPDHHAIENLRKIAGLASQRDDKAIFVMAMLLEGLAHLASRKDDWVNRVQTCIAHAAKLQMDDSVHHPQSDVLILLLDLACSLHQKAYNMSAQKMGALQKRLEELKQSPDWPSRSGEMLLPIKRIPNVQQTVSTDTRAVLRPGDDDVDYLVLSALGKQEAFALAFVFNGIVACYKASTPARSSSMWGEAIRLLEDGKAVSPPQPLPVALEQAEWARELSCYAHILTGLQAATLSDWAKVKVCLETAQNCSSQTDFLDILTLYLQGVFYQGTAQLEKAIEIWKDPAFEVDPTGIPKPGTSRIQMELSILAALNRIWIMQEPGQRDDAELAEIIDLLRPICEDNPDHEIRTVYNLVLSCAQLNPPLSINQVKRHIQNSLGGAQMTCNTQHLAIALNVMRCRLFENVVGEQALKSAKAGAAQARKSGNVLWMSVAEGMLAQSYEMQGALELAREAHESGVKYANEAYHRTQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGM2</accession>
    <name>G0SGM2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0066840</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696979.1">
        <property type="nucleotide sequence ID" value="XM_006696916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGM2"/>
    <dbReference type="GeneID" id="18260722"/>
    <dbReference type="KEGG" id="cthr:CTHT_0066840"/>
    <dbReference type="eggNOG" id="ENOG502SF4J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035048_1_1_1"/>
    <dbReference type="OMA" id="VSCRRIA"/>
    <dbReference type="OrthoDB" id="5338512at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409487" description="Mid2 domain-containing protein" evidence="7">
        <location>
            <begin position="23"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="145"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="311"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="153"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="366"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS17361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="47690" checksum="E3D01322C3F3F7D5" modified="2011-10-19" version="1">MPKRKLALWAAALCATATHVSAYSISRYDVLLSRQANTCSVSGFSPCQYGNFPNNFCCPAGQTCLALAGNTTILCCPNNVSCRRIAPIPCEISLQDVSKNPDAVIKTTALNVPLGKCANACCPFGYSCKDDECVMNDDQSKVPEGFKPSTTVALTPTSTSEASLATSRLSSTSTSPTSTAISVPAEDGGEEGKKSGIPVGAIAGGVTAAVVIIMGTAILACIFYRKRQAANSSPKSKHSYISAPIPYGETIRTDFNAKAAAKNANYDSEFEPDSVTGAVLKDRMTPSVSQGASPDMGNAYGTSKEGYGGYGGLGTTTSGDNKAPPRLEMPTFSISSSEEDNYRTDVSPLSSDGYSPNDTNTKYGPNNNASTSQQAQAAREPSSMTLPFCADPNITRDRTGRFREYQYGALPDDGDTDRKRETRMTTFTQMLESVDLGGVVRGEGYVPRKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGY3</accession>
    <name>G0SGY3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0067990</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697090.1">
        <property type="nucleotide sequence ID" value="XM_006697027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGY3"/>
    <dbReference type="GeneID" id="18260837"/>
    <dbReference type="KEGG" id="cthr:CTHT_0067990"/>
    <dbReference type="eggNOG" id="ENOG502QXVT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017895_0_0_1"/>
    <dbReference type="OMA" id="HPECGKT"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="378"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="410"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="162"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="269"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="439"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="532"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="701"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="273"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="539"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="708"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS17472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="733" mass="80851" checksum="2C728AE25212632B" modified="2011-10-19" version="1">MRTKPRCLRPLTVNLEAVDPCRLPPSPTPANQNQQAGLLLERSPRAERTTPATLEAYSKHRNVTGCDLYTQPPAHQASPTTDNRGGTITRIASYSNIHSATMTYPDPPQFSSASLDLGLSSEPYSAYPRSASDYPTTTMGYDSAMYAEAPYVYGNGKGSPGLYPDDSDMHGTSSDLSIASASSSNAGSPMSTHGQIAPVNEWTATPHGLGVTPGIVDHNDYFPGNEYAFTPNGVEAYTPSYDLAASKVPGFVDPSLIHPEVRAMAMPNNYEQPYSAPPTSSTYPTSPALSVTASPQLRAGSTSPFVPNGNYQHPYSPFQPPVDQRRGSLISFQSNGSTEQPYSGDESREKQRCPHPDCGKYFKDLKAHMLTHQSERPEKCPIVTCEYHIKGFARKYDKNRHTLTHYKGTMVCGFCPGSGSPAEKSFNRADVFKRHLTAVHGVEQTPPNSRKKGSSSNNSTKPSGYAPDATGKCSTCSETFSHAQDFYEHLDDCVLRIVQQEDPAEAVNAKRLAEVENDPEVVKTLTKNNLPVTTVVPNTEEDGEDEHMEDLEGDDMSRRSSKPGVMSPTRKTKPTNPPNGVQKSRGMTHSRGGVPLIKPRSRKNRQNYPQSWGFDKGQMTIKKRVLTVFDGPRRLVKDDMMLSTEQEVRIRLQDKKHYITDLDLQTLKRAEGFLNATDEEKGPWISDDPTKEEMKLMLELSLQQSADKQTKQQDEQKPQEQQQKPSEVAVVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0SH79</accession>
    <name>G0SH79_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0069030</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697186.1">
        <property type="nucleotide sequence ID" value="XM_006697123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SH79"/>
    <dbReference type="STRING" id="759272.G0SH79"/>
    <dbReference type="GeneID" id="18260941"/>
    <dbReference type="KEGG" id="cthr:CTHT_0069030"/>
    <dbReference type="eggNOG" id="KOG0682">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_33_0_1"/>
    <dbReference type="OMA" id="GFPTTPM"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000003">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF10">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="9">
        <location>
            <begin position="37"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS17568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="475" mass="50304" checksum="A2629B806CB82CE6" modified="2011-10-19" version="1">MSSGTPEEYTGVTGVADQGVNPMLDDPNKYYSNGDFAWILTCSALVLLMVPGVGFFYSGLARRKSALSLIFLTLISISVVGFQWFFWGYSLTFAPNGSSYIGNLDNIGLRKVLAQPSVGSSALPEILFCLYQGMFAAITPALAIGGAADRARVWPVIVFFFVWATIVYDPLAYWTWNPNGWSFKLGGLDFAGGTPVHISSGAAALAYALMLGKRTGYNKVNGLPYRPHNVTHVILGTAFLWVGWFGFNGGSALAANVRAAMACVVTHISACVAGFTWCLLDYRLEKKFSAVGFCSGVIAGLVAITPAAGFVTPWAAVIFGVVGGICCNFATKIKFLVGIDEPLDVFAEHGVGGIVGNLLTGIFATDYMAALDGSGPTGTIEGGWVNGHWIQFAYQLADSVAGFAYAFGMTCIILSLMNLIPGLSIRVSAEEEDLGLDDTQLGEFAYDYVEISRVVGGDAPSSAPSIKGGKTELPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHL1</accession>
    <name>G0SHL1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TM7S3/TM198-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0070420</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697318.1">
        <property type="nucleotide sequence ID" value="XM_006697255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHL1"/>
    <dbReference type="GeneID" id="18261080"/>
    <dbReference type="KEGG" id="cthr:CTHT_0070420"/>
    <dbReference type="eggNOG" id="ENOG502RXUE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003667_0_0_1"/>
    <dbReference type="OMA" id="WRIIRER"/>
    <dbReference type="OrthoDB" id="102260at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025256">
        <property type="entry name" value="TM7S3/TM198-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39469">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39469:SF1">
        <property type="entry name" value="DUF4203 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13886">
        <property type="entry name" value="TM7S3_TM198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="TM7S3/TM198-like" evidence="7">
        <location>
            <begin position="50"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="265"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="596"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="896"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="943"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1024"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1154"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="332"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="351"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="640"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="907"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS17700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1175" mass="127489" checksum="53BDC588244880A9" modified="2011-10-19" version="1">MNSSVFQNATRTMSEPTPTVTSIVDLLNTTIPAGQLPLKPVITPGWSVAGTILLITGLFYTLIGIRAKRWHTFFGTAFLGALGTTVLILYLMTPPVSNAVQGGFVVAAVFTGAVLGGLAVVLIDVFDCFGCLLGGFCFSMWLLTLSPGGLVKKKSLKIVFIAVFMVAAFSLYFSRWTRRYGSVGCIAFSGATAVVLGIDCFSRAGLREFWAYLWELNDKLFPDGTVTYPLTRGIRVELAVTVILAVMGAMSQVKIWRIIRERREKGNKPSDKEEEELPGSDEEEAMQRRQMEEINREKEEWEKIYGNGRSSDTEIGTPETRKTSTEGSVAKDGPEGEGKGQRKDGEGEQQVPDDDDDDDDDDDDDGRDSGVQGIEEDNDQGKVAKKQTPPETAHPAMAPKMMARERMTPDSMVLPENHPPMTPQTDYQTPSIPVDAEHDDGDRSSVAATVDETDVCQEPEIPVPPELPARSERRPRSAMISPVPGHESVPATSTPAKPVFNYAPPIEPQEPLRADSDSIAATLDSLGSDRGQYDDDLDLDYSADDARRMALDQKTQLTVPSTLGQRTSQLTSDVSAQELTARAVEMVRATLATVPEPRRMRGLSRSSSLPDISTPSRSSVRRSKSEGFLVPWGHTPVDPKPVEEQHQEARSNKDAESNVSFRTALARLTKSNLPPAFPQVALTYRMQEWAKHLDAAETPEPDPLTIEEGRAVSPDGEQAAPVDVRDLQMTPQNASVPPAVLPKRVSAMSGHEQYYSSSGSTGGRTSGSSYPDLAGYLFPNPPTANKVNRRSASAMARGLQEEAIAEEVSAGMSVRKNEQTVESGGKNPARGYYRVSSSASFPDLLDAQQPLALQQQPKPQTLIGMREMLLKTRASIVNNGLANDTTLHIPYEAARPASDAGSVRNYPVSPGLQSSSGSPPSTRPSADLDDLPLSQRRALLQRSSSVLSNHSTGAPTPIPPTTMGTNPGLAAPAPLVQTTLAPVMPTTPTPILPPITTTPQLTPEAARQARLASFRASVAADLQSRSPPPIISRGHSPTPGAGPSSLNLNLNINPSLQSLQHTYQSYTPYLNGTTTNPTLTNLIPSNAAAAEAQRQQQERAEALRTMELRRSKLLSERQAEAARREAQIREKKRIEREWETRMVFGGKEVMEMHRGALRRLQSGSQSKTKERGGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHM6</accession>
    <name>G0SHM6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0070570</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697333.1">
        <property type="nucleotide sequence ID" value="XM_006697270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHM6"/>
    <dbReference type="STRING" id="759272.G0SHM6"/>
    <dbReference type="GeneID" id="18261095"/>
    <dbReference type="KEGG" id="cthr:CTHT_0070570"/>
    <dbReference type="eggNOG" id="ENOG502T5GN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_422721_0_0_1"/>
    <dbReference type="OrthoDB" id="4582308at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="648" mass="73298" checksum="3AEE06722CFFA32B" modified="2011-10-19" version="1">MYASAGRQAYQISPFSSVKCSISYLKPEFKTLLSSYQQQKAQTFQEHHDEESSKLPHETISLVNLPSEILNQIFCEVKWDSPTVPFELDGLQFYENLTANESYIASIRLTCRRLASAAAPWLMLAPCVSLTDPESIDHLEQIAAITSFSPYVKAVRVSAGFYSEEIAQDIRNSAKYLIWNVEGIKRVLEDLGYQDVVSTRLPGNRTPEKWDKILDEWKALSNNGDEQDQRGGKSELSSASVDRDSEAMQLLEKEHTEYQRRFNKQQKLLMAGPESAVERIAGAIAKMPQATRLVLSDASRCADYSIPKIPFEGGDGWLLSPMSWASYFKLHYSLGDHPARIFDTILNTLFNLPIAIHRAGVNLTALRPSCSSPCGNGSLGTRKKISRTTPFSPRPKNCERRAATCVSSIFTPDYLPGCVLTDSPNWLAWPHIGYFRRHPTIRSITHCEELLGWIMTAACNTLTHIRADELFMAPDAGEFAMPRGFPEGTALRLSNIQVLCLQNLNISLGILPRFLSYACATLRRLILFKVILKSYPIPSPRNLRRCSWACLLDEIRPYTMSREMEGGKAEHRVVVKIRKPTGYEIVWFDASDPNHSLMALFEPDDETPDLWAPSDQPYDIFEDEGSNYRDHLYHGFSPVDKYLMGWRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-12-14" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHN8</accession>
    <name>G0SHN8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0072820</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS16958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697540.1">
        <property type="nucleotide sequence ID" value="XM_006697477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHN8"/>
    <dbReference type="GeneID" id="18261320"/>
    <dbReference type="KEGG" id="cthr:CTHT_0072820"/>
    <dbReference type="HOGENOM" id="CLU_1749427_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS16958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="149" mass="16291" checksum="5EB5EF65B6DA84D7" modified="2011-10-19" version="1">MIILEPLQRRTAQSCYEEALRLSQTEDGSATPTPAAPDAVDTEYPTEIRRYIRSNGPPPETVLGDEGSLGDSLVAAPDAVGIEYQTEIERCFRSNMALPDILPVNSATRARASQNAISDKHSLSQGKAPIRKRFNARQQNCKTASVAKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHW3</accession>
    <name>G0SHW3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">STB6-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0073590</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697615.1">
        <property type="nucleotide sequence ID" value="XM_006697552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHW3"/>
    <dbReference type="STRING" id="759272.G0SHW3"/>
    <dbReference type="GeneID" id="18261397"/>
    <dbReference type="KEGG" id="cthr:CTHT_0073590"/>
    <dbReference type="eggNOG" id="ENOG502QT8Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010065_0_0_1"/>
    <dbReference type="OMA" id="AKFYQLY"/>
    <dbReference type="OrthoDB" id="19806at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070822">
        <property type="term" value="C:Sin3-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038919">
        <property type="entry name" value="STB2/STB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059025">
        <property type="entry name" value="STB6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31011">
        <property type="entry name" value="PROTEIN STB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31011:SF2">
        <property type="entry name" value="PROTEIN STB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25995">
        <property type="entry name" value="STB6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STB6-like N-terminal" evidence="2">
        <location>
            <begin position="81"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="674"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="911" mass="98964" checksum="7A33AA88ECBF3FE6" modified="2011-10-19" version="1">MALWLTYPSTALDDRAHRDGELAPMGGQRTTAAAAAASHHNINAKPAPSDADPDPEDNGSAPAPTAMGTGSLPTVPSTRRRVVVPDPVALKFLEVDPSVTIAQRRHVLHGYELYLVEQWACSRQTPTVVIVTYTGDPKHSVTVGVLEVPADEKDWSDRLKFYFSSIQQYHARPKETDMGEVMVTNLSSFPSALTVISVPEGDLLKYREVFIVNENLKRLGCAGRSGLTLAEPSSATQAKFMQMYKTSDRIPFFQAVLELVRLCQIALFLFGMLQEEYTDGLLCDVTEQAINDWWTEIGSECFNVEPSDGILGPITVAAILGTLMGARNRLSYSGAPVSKDVFDIEATKKGIGSFQKSLKLERTRRLDRQTLLKLRQVTAKAAAGEAGWGVQKAVKSTVAEFGKRGEIVIGMVSGKDKANIADIETLDFSKFVSLAYGERPKWLWYGKPRRTALDRDHSIPSMPPFGKEELVLLQQSGKKTHSTEDELEAKAREDTFVGSISAQAGSVQVESPGSDKDPLRKNVFKSVAGKVSDARSGLVRIRDAVGGGLSRHVSRPSKDDISDTLLGAFSNHGIAALAHTSAALSSPVAVGKAFPWKLKPEDVLPPLNEKEAGRSAPLVTGPTESDMATAAKDGIARRPSVSEPSLTETAKEARTASAPGSVTAESDGQTPAQTTTTTTTTTTTTTTTSSVDTTLLTLKRRHTCDCLSSLSRRPVSEARYPRRMSFSEAEEAVLTWEELITLADAPTASISPTLPNPQAELAHRLYTRLSTLQSDLAPWVSTQLTSVTGLNQTLITQQTELQNLYASLRENYTYTRQQIADTLLEERARLADAVKDVEGLAAKLEYEIGVLASRVNEVEDGVDQFAMQVEDVEGRCEELKTALETESWLHWFVRTLTGIGTGPNITREGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0SI16</accession>
    <name>G0SI16_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0074150</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697668.1">
        <property type="nucleotide sequence ID" value="XM_006697605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SI16"/>
    <dbReference type="STRING" id="759272.G0SI16"/>
    <dbReference type="GeneID" id="18261453"/>
    <dbReference type="KEGG" id="cthr:CTHT_0074150"/>
    <dbReference type="eggNOG" id="KOG1630">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046868_1_0_1"/>
    <dbReference type="OMA" id="TLMWSER"/>
    <dbReference type="OrthoDB" id="1277691at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF112">
        <property type="entry name" value="GROWTH HORMONE-INDUCIBLE TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS17086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="340" mass="36646" checksum="504E7973FE3448C5" modified="2011-10-19" version="1">MSFTLTLRAGLSCKAPQLGIRAFHQTATKNTFFTARTASLAFRASSKSGSSILTRLNATRSRGYQQYAYADPTARKAELTRKLLIGGAVFGGTLVAVNAVFNQEGRTDGGMPLFERSYLNKTFMHTGLGVGIIGLTAYQMIQSGFVYRIMVTNPWIVGLGGLALSIGSMVATRAIDPDNYIPKYLCWTAFNATQAAFVAPLMAIAPPALLARAGLYTLAMMGSLSIIGATAKQDKYLYIGGPLLAGAAIVAVSGFAPLVLPATAVRTLAFTEKLWLYGGLALFGGFTLYDVQKVLYHARLARAGVIKEDPVNESIGLELDFLNIFIRMVQILMMQGQRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0SI63</accession>
    <name>G0SI63_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EKC/KEOPS complex subunit CGI121</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">EKC/KEOPS complex subunit cgi121</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0074650</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. CGI121 acts as an allosteric effector that regulates the t(6)A activity of the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators. CGI121 is not required for tRNA modification.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the CGI121/TPRKB family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697715.1">
        <property type="nucleotide sequence ID" value="XM_006697652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SI63"/>
    <dbReference type="STRING" id="759272.G0SI63"/>
    <dbReference type="GeneID" id="18261503"/>
    <dbReference type="KEGG" id="cthr:CTHT_0074650"/>
    <dbReference type="eggNOG" id="KOG4066">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065847_1_0_1"/>
    <dbReference type="OMA" id="DANPHFD"/>
    <dbReference type="OrthoDB" id="329139at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2380.10">
        <property type="entry name" value="CGI121/TPRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013926">
        <property type="entry name" value="CGI121/TPRKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036504">
        <property type="entry name" value="CGI121/TPRKB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15840">
        <property type="entry name" value="CGI-121 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15840:SF10">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TPRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08617">
        <property type="entry name" value="CGI-121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143870">
        <property type="entry name" value="PF0523-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS17133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="204" mass="22621" checksum="073BAF1A5F89E966" modified="2011-10-19" version="1">MALENVALEHVPSGYGVYVGFFRDVTNADFLHQQLLSRNRDFEYAFIDASSVISRLHLLSAVYSALNTLLVGALRTPNVHSEIVTSFNTNNNIADAYRRWGITPGKTKDLIVVKIISPTAEGQNGFSATSARTPEAIWAHLTEHVMGKPVPVTDSEIAQATDWPKVRKYYRLNGVPALEKVADKAEHQRKMEQLAIMGMALRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0RY14</accession>
    <name>G0RY14_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0005040</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691042.1">
        <property type="nucleotide sequence ID" value="XM_006690979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RY14"/>
    <dbReference type="STRING" id="759272.G0RY14"/>
    <dbReference type="GeneID" id="18254542"/>
    <dbReference type="KEGG" id="cthr:CTHT_0005040"/>
    <dbReference type="eggNOG" id="ENOG502RS64">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013811_0_0_1"/>
    <dbReference type="OMA" id="DAKYRKC"/>
    <dbReference type="OrthoDB" id="49395at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030705">
        <property type="term" value="P:cytoskeleton-dependent intracellular transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22211">
        <property type="entry name" value="HkD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947:SF28">
        <property type="entry name" value="GIRDIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947">
        <property type="entry name" value="HOOK PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116907">
        <property type="entry name" value="Hook domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="185"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="444"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="647"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="815" mass="93551" checksum="42CE1D41CB52728D" modified="2011-10-19" version="1">MTQYSPSTQAALLKWVGTFDTVRRAQSLQDLRDGVILGQMLEQMLGTEFHSDSLIQSPRSDDEIRQNLEAVYRGLAGFLRVDNPSLAPSPSEFRSIAESLDDNALCEFLSYFLSAACLGSLSTTYVPKVMKLDQQTQAEIAKIITEKNQLKTETEEQEEEPQSESVDDFENVYPVRDPELMAEELEQMRDKIEILKRQNADLQTRIEKLMDTREALLGDLRMAQDELSTLKRARGSDVSSTIRDLRNEIREKMVEIDRLEDLLEKETARANKLEKENENLRAKAARVKDLEDKVTVLEHETKQQQQMIKGLENYKKKAQDLTAIQQRNRLLDEQILQLEQELKMFEEVKAQNRRLQREIDEKMKVLSNNEQEIIYTLQSKNHLQEANEELKRRIEYLESKRQLDEETIEKLQEQLHYYESSGAAAAGPLSLEEELEGGGGGDPSVALRLEIQRLKAENNLLRNNMTVASENERLRGELDTATQKIDHYRLKCTEAMQQHAVIEEQLTALMNHATTESDVAFVNMRKELTAATRELEKARKHMQDLEREAADRERELLRLKADLEAVGKDETAALAALKASDELISESLRTELEATRKQLQHRVFEYDQMKEQFMETLVSKDRVQKKLEEALANTGEGPKGEMAQKGRKEDAEKIEKLKAALRQKIEQLEKAEQEKYDLQRRLKLAETKAASDQMIRNLQRENAMIATAWYDLTSRLQSNHVVLQRRHDAPRSWVNKQRQMVYVFHFLNVALEAAAGRVEVWKRFAAAVAEALGSNAAAVDRPEDEEYELEGVITADDCDEDDAAFLREGDSGIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYR6</accession>
    <name>G0RYR6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0007640</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activation signal is received. Near telomeres, it may counteract gene silencing caused by the spread of heterochromatin proteins. Required for the RNA polymerase II and SPT15/TBP recruitment to the target genes. Involved in chromosome stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS24052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691294.1">
        <property type="nucleotide sequence ID" value="XM_006691231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYR6"/>
    <dbReference type="STRING" id="759272.G0RYR6"/>
    <dbReference type="GeneID" id="18254802"/>
    <dbReference type="KEGG" id="cthr:CTHT_0007640"/>
    <dbReference type="eggNOG" id="KOG1757">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062828_2_1_1"/>
    <dbReference type="OMA" id="MNKKGAP"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000021">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="12">
        <location>
            <begin position="18"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="13">
        <location>
            <begin position="105"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS24052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="143" mass="15235" checksum="37E4544F438CBDD9" modified="2011-10-19" version="1">MAGGKGKSSGGKSSGGKTSGTDGPKKQQSHSARAGLQFPCGRVKRFLKQNTQNKMRVGAKAAVYVTAVLEYLTAEVLELAGNAAKDLKVKRITPRHLQLAIRGDEELDTLIRATIAFGGVLPHINRALLLKVEQKKKAKAAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYZ5</accession>
    <name>G0RYZ5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0001120</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690665.1">
        <property type="nucleotide sequence ID" value="XM_006690602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYZ5"/>
    <dbReference type="STRING" id="759272.G0RYZ5"/>
    <dbReference type="GeneID" id="18254150"/>
    <dbReference type="KEGG" id="cthr:CTHT_0001120"/>
    <dbReference type="eggNOG" id="ENOG502S9TA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003071_0_0_1"/>
    <dbReference type="OMA" id="VFSYWRR"/>
    <dbReference type="OrthoDB" id="5408302at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="590"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="682"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="855"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="906"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="991"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="632"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="700"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1111" mass="116048" checksum="C3CD0DAE4BAA083E" modified="2011-10-19" version="1">MLSHLRFHRRGPSNPTSSLPDRSPARDGAAAQHEQLQAARDVSPRPDASQRSSNSVEKPPILPPIPRVASPTNDEDSSSRNNAQSIAQAIAAEPRKSSAGSSHGNTSTPSFIGGVALQRAMQSSQSTDATSVMSTPVLPSQISRVKHPPPPITTTLPTETPLTTSKRSKSKTFAALTAPEPHKPKKGLPFLNSVASLLGRRKTSHGTPDPQPAPSYDPRIKGTKVHDFSAPRPRNTPPATKPPVTDKSQSASLASRPTSLVEVAYPQPGPQDCTAHSTTDGVTAVPVAPASQEGSVPDDTPLEPSQHTDGAAASTDIAAATEADVVSALPDTSASVRTTRNISKASKRSSVSSSLPKHMKSTSSRFSFDMIGAANQEKLLEERHRQRAREKGLTNDDCRGSSSLDYYDDEFDYDAMMDDDGLEEKIPGINADLEEEEEDYLTGEAEQQNLAGFVFQNSTPASALASPLSSAVPMTPRDVDGNVIGCAVTKDLTPDPSTVASPVLPVPPASLGSQVPVEGMDTAVQLLPPVADPPPKPKDLGMFDDVFDQDLADELDFSNDGTHFDESIFDIEDTDQYGRPIPGAFQKAKEAMYARQREQLAAKRESSMTTTDASAQSGVAQSTAHTSLSVAPQQQDPPSSEQDNKDGSVSPKSPVSSAPGPISLSTQDLAYQAALAEAAQKAAASGKFRRDSSPEPPSSDLQQPNTQQPAAGTVTPPNQYDDYEDDADFGYTAICDDDYGAADDAIIAEANATALANDHEGFYGQEFGFYSAPIPQPGYYYTHHLNNMNSADPNNPNTVPGNPLFEYANGGYFGPTSLMRTHSGRVVSREPNLTPITERSEYSNRNSVMSFTLPPAIGDGPNTGTGGRNSLSSAGAANPNLAQLALLQDDDASLPGMQQILMIRRGWGAGGGSQGSSREGSPRSERTPASEMGFGHARVGSGFSIRSNLSDVVAGVGGAVQGSGAASPVMGAAPVTGLNAFAGATGTPPYRPGSAGGLAPNTLASQRPGLPQSPLFMSSLGPVAAPASPQQVPVSPAAAVPNAGVSSCETVMEGEEVEGGEKGEGQGEEKPCLLAPSAMPLGMKSAPDGVASVAKGVEKVKLEEKEEQEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZ91</accession>
    <name>G0RZ91_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ras guanyl-nucleotide exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0002130</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690761.1">
        <property type="nucleotide sequence ID" value="XM_006690698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZ91"/>
    <dbReference type="STRING" id="759272.G0RZ91"/>
    <dbReference type="GeneID" id="18254251"/>
    <dbReference type="KEGG" id="cthr:CTHT_0002130"/>
    <dbReference type="eggNOG" id="KOG2378">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005431_1_0_1"/>
    <dbReference type="OMA" id="HIAKWVA"/>
    <dbReference type="OrthoDB" id="28357at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF348">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR RASGEF, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="572"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="808"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="167"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="446"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="705"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="34"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="170"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="461"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="502"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="705"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="716"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="744"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS23519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1064" mass="116485" checksum="782880190B992388" modified="2011-10-19" version="1">MWVQDRSGAALPQSSVPWSTPPGRPGAVGTMGGADAAVSTAAAAPAITADAQTTTRSTTKPTTGSTSTQSNSSDAKNSSSIHSSGHNTTFLPGTEGTFFLVDDPPEPPDSDTLGPLKTSKHRDPSPSGLRANAATPSHSVRDSIASIVDDPFFRRYANLIDASPAPNPHAPSALSLTSKSVTTPSTGTAATSAATSPTTLTTATSVTTSTNATTATTPTTTTLGSGHRNDDRPSWIPPRKDSLTDPNPTPWVRRPLLRLETRQTDQLAQFECARHTMEPLNIAVIGSEGVGKSTFIQHLRRAPRPSSSNITTLKHELDGALYHVTLVELDLEGIPKLDPNQPVLWPKQIGGHMVPRMDGALLLYDGLNEETMRELPTVMAALANSSLPTVLVATKSDAPDDFRHRDLAGVAASSPTCAGHFRTSANAPQSIRECLQAMMRAALTARKDKAEGVGQRRRAASTANLDTPSDLSNGRPMSQHSKHSRASSDFSLVRGNEGGQYRGQSSRSPRSENQGSSSASIPEDGQQTVQGMLRTPGVRLDGGNDSSFLDVDESDAEGYRYGDDHDHRHDDKAAKLPGVTFDELVDRLVAPKMTRTDHNFVDVFLCLYRTFAAPSKLLTAIRARFDQVAADQSMQMLAKSEAQLRIVEVVAKWLSLYPGDFARPVSKNSLAEFVNQLMAEPVFVAAAQQMKRNLEHKVIEDDDTWWENSDPVEEPADSKDVAEKRRSGIAESMNSLQLDDHHSTSASGQRRPSQSSDLARHELPHASRPKAIFTFHTVEDYEREAATLVPTGLYPLNKFRYHTFMEIDPDDMAEEITRIDWIMFGSIRIRDLVRHVSLSHDQKEKCRSLKNVNRMVNHFNHIAQWVANMILIRDKAKHRAPCLEKFMGIAARLRQLNNYNGLAAVLAGINGTAIHRLAQTRALVAPDVQKRFAGLVLLMGTQKSHFAYRLAWENSPLPRIPFIPLHRRDLVSAMEGSKTFVGPDGDRINWKKFEVLGEVILPIMKSQGQPYTTLHRHEVSRELILDVKISTDEEEIYQRSVQVEPAGAAASAESSKKKFPWLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZG8</accession>
    <name>G0RZG8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AT hook domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0002910</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690838.1">
        <property type="nucleotide sequence ID" value="XM_006690775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZG8"/>
    <dbReference type="GeneID" id="18254329"/>
    <dbReference type="KEGG" id="cthr:CTHT_0002910"/>
    <dbReference type="eggNOG" id="ENOG502RKXA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_436126_0_0_1"/>
    <dbReference type="OMA" id="HINDQAL"/>
    <dbReference type="OrthoDB" id="5404794at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="627" mass="68459" checksum="F0AD161A242FF682" modified="2011-10-19" version="1">MTMSRQRPREILDSDDEGSVFGDSDYNCEQTLDMLPDTQDASYEANHEVVLASHAATESTDPSFFQRVYDAQYAAVAGQPDESGLIPDTLPGKDWVSVGTDTGPATATTSQRKRRRGRIQETDVVDLTSPTPLEKNNNSDVWDVPNSAPRQRNKRTYGRQRDTESDELAPTQDPFAVPEETPRLKRTRVRRGEVATQSSSPVMLVPSNTAEGGADSSSVNTEAGPSLYIPQSELAASQKQECQVVSLSPAEGSEVVSDTFAHQHQPTSSEIEEVATTALYKSSGMTTIAYPTPSRVKSSLRRREGQMEAQISGWGVYEPPQSSPDVLADLTSTENPKAKRTKAKVVSSTVEEKETPPSIRLPKKRRVVQDEDEGYGDWQQVTSMEQHINDQALSEEVPEGGADEQFGDQSVAPPALESPEIATKQLSPPVESAPKKRGRPRKRKFEEDMTPAQKEPAPVPTEPEAPVPPAKRKRGRLRKSEVKPTDDMPAQPAVETEADAIGSNPETLTEVQVNPQPVMAQPTEDSRHKEETADSSESKENNGNGPSKPATAKDSMPAKRNVDEYEETPIPKEEDMEDGGSKEAATPAIVLPKLNLGMKAQYRVGLSKKSKIAPLLKSLKRPTSTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZY4</accession>
    <name>G0RZY4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 NT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0008060</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691336.1">
        <property type="nucleotide sequence ID" value="XM_006691273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZY4"/>
    <dbReference type="GeneID" id="18254844"/>
    <dbReference type="KEGG" id="cthr:CTHT_0008060"/>
    <dbReference type="eggNOG" id="ENOG502R9IN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023134_1_0_1"/>
    <dbReference type="OMA" id="WHLSHSM"/>
    <dbReference type="OrthoDB" id="3365224at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039931">
        <property type="entry name" value="EEIG1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019448">
        <property type="entry name" value="NT-C2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456:SF1">
        <property type="entry name" value="C2 NT-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10358">
        <property type="entry name" value="NT-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51840">
        <property type="entry name" value="C2_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 NT-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="542" mass="59237" checksum="3CE245EE0FBAAB3E" modified="2011-10-19" version="1">MTSLSTDALSQPARVHPMPKFEVHLKIADLNNVPLVSGVSMVKWHLPGSIHGEHRGRTDKCPIVNHRVEYGYAKIFPVRIAIDRNNSLCECPIEFEVHQEFSATGVAGAGSRDEKITLGIVRLNLSEYVEESEAILRDTATAAAIKEALTSSGRTEKPGHHRRRSSVSESTIPTIGSDPSPRSSRDDDSPPSLPATDVQDGVVRRYLMQDSKINSTLKISILMVQVDGDKNFVAPPPKSAPVFGGIAGFVASDAFEPVDVNTVTPGHAPSSFSGKYRDLSEAQDVYRRALAASWASQPGELPADQCIEDIFAGGEGFPPPPNPKTHGRGHSRHHLSIAGHLHGQDRPRKSRARRNRPPSRREDSGSASDDEDNGTDVMGTVRARDFVNLRRHMSSHSLASERSTTTVATVLARDHNSGPDRESSHERPRGGLGAGFSASSSSLHQREPFPPFPSFFQHRREESKITYGGGLRSRTGSLASLANTVGSDKGYDSRGRDGFKRAREVDEFEIREDLIAWTVPGAMAHLRFIGHILTEPHQYFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0S007</accession>
    <name>G0S007_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative vea protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0008290</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the velvet family. VeA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691359.1">
        <property type="nucleotide sequence ID" value="XM_006691296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S007"/>
    <dbReference type="STRING" id="759272.G0S007"/>
    <dbReference type="GeneID" id="18254867"/>
    <dbReference type="KEGG" id="cthr:CTHT_0008290"/>
    <dbReference type="eggNOG" id="ENOG502QVY9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022491_2_0_1"/>
    <dbReference type="OMA" id="TDITFSY"/>
    <dbReference type="OrthoDB" id="5384689at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034250">
        <property type="term" value="P:positive regulation of amide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051176">
        <property type="term" value="P:positive regulation of sulfur metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043455">
        <property type="term" value="P:regulation of secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.3960:FF:000001">
        <property type="entry name" value="Sexual development activator VeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF14">
        <property type="entry name" value="DEVELOPMENTAL AND SECONDARY METABOLISM REGULATOR VEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0749">Sporulation</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="10">
        <location>
            <begin position="34"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="245"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="253"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="338"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="367"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="410"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="423"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS23168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="595" mass="65606" checksum="B41F42614CC1658D" modified="2011-10-19" version="1">MGAPIAAAPNHSVQVDTTGAVIEPAVISRETKGGRRLWYSLKVIQQPERARACGSGPKSSADRRPVDPPPVVELRIFEGATWQEAQQKDITFHYNANFFLYATLEHARLMAHPRGAPAPPANVPVLTGMPVSGMAYLDRPIEAGYFLFPDLSVRHEGRYRLSFNLYEQTKEEKDKDKDACNADLIFAPISDMNHPAAVESFDWRMEVKSAEFIVYSAKKFPGLAESTQLSRVVAEQGCRVRIRRDVRMRRRDNKGSNRNNEDGQYRNDRRTATPEGARTEYHERARSMSGSQERTPYPAEPHRRPSMHEYHAPPPPPPPQYSQQNSGPAGRHLQFLTNSNSQYPGQPQQSYSQAQSVPQSPVGTHYQPPPSYANPPPPPPPPSAPARSYSRERTPGPSYQPAPPATTPILRREGSQPSEHSRPPSQSCTLPPINNISQFAPSPGTVSQHTPPPPPPLATPTQHHASLAPLQPSTKENKVMLPPIDTSRISNSRPRPTLPSPATLAAVPRPPSLSAGPINPLTLPPPPPLAGSKRARDETFAQPAVQRYQDGQREKGAADDLPSEYTGNASPMWFERANGHRKDALKLNDATRFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>G0S027</accession>
    <name>G0S027_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="17 18">Plasma membrane ATPase</fullName>
            <ecNumber evidence="4 18">7.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CTHT_0008510</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O + H(+)(in) = ADP + phosphate + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:20852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 18">Cell membrane</location>
            <topology evidence="2 18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.1" evidence="4 18"/>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691379.1">
        <property type="nucleotide sequence ID" value="XM_006691316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S027"/>
    <dbReference type="STRING" id="759272.G0S027"/>
    <dbReference type="GeneID" id="18254889"/>
    <dbReference type="KEGG" id="cthr:CTHT_0008510"/>
    <dbReference type="eggNOG" id="KOG0205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_6_0_1"/>
    <dbReference type="OMA" id="VIEFHPF"/>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008553">
        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02076">
        <property type="entry name" value="P-type_ATPase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000011">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000005">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000008">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006534">
        <property type="entry name" value="P-type_ATPase_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01647">
        <property type="entry name" value="ATPase-IIIA_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 18" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="15 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 18" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 18" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="286"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="323"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="689"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="716"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="756"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="823"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="855"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="20">
        <location>
            <begin position="67"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00071631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU362083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EGS23188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="917" mass="99614" checksum="B29C82B10F370DA4" modified="2011-10-19" version="1">MADHPAGGAPALSTNIESGKFDEKEVIRPKHVAKEEEEDEDIDALIEDLESNDGHGAFEEEEEVQPGGFRVVPEELLQTDTRVGLTSEEVIQRRRKYGLNQMKEEKENLVLKFFGFFVGPIQFVMEAAAVLAAGLEDWVDFGVICGLLLLNAVVGFVQEYQAGSIVDELKKTLALKAVVLRDGTLKEIEAPEVVPGDILQVEEGTIIPADGRIVTDGAFLQVDQSAITGESLAVEKRKGDQCYASSAVKRGEAFLVVTATGDNTFVGRAAALVSAASAGSGHFTEVLNGIGTILLVLVILTLLVVWIASFYRSNPIVMILEFTLAITIVGVPVGLPAVVTTTMAVGAAYLAKKKAIVQKLSAIESLAGVEILCSDKTGTLTKNKLSLNEPYTVAGVDPEDLMLTACLAASRKKKGLDAIDKAFLKSLKHYPRAKSVLNKYKVIEFHPFDPVSKKVVAVVESPQGERIICVKGAPLFVLKTVEEDHPIPEEVDQAYKNKVAEFASRGFRSLGVARKRGEGQWEILGIMPCFDPPRHDTARTVNEAKSLGLSIKMLTGDAVGIARETARQLGLGTNIYNAERLGLGGGGDMPGSEVYDFVEAADGFAEVFPQHKYNVVEILQQRGYLVAMTGDGVNDAPSLKKADTGIAVEGASDAARSAADIVFLAPGLGAIIDALKTSRQIFHRMYAYVVYRIALSIHLEIYLGLWIAILNRSLNIELVVFIAIFADVATLAIAYDNAPYSKTPVKWNLPKLWGMSVLLGIVLAIGTWITVTTMYAHPNGGIIQNFGNMDEVVFLEVSLTENWLIFITRANGPFWSSIPSWELSGAVLIVDIIATLFCIFGWFEHGHQTSIVAVVRTWIFSFGIFCVMGGLYYILQGSTGFDNLMHGKSLRGSQKQRSLEDFVVSLQRVSTQHEKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0S085</accession>
    <name>G0S085_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0009130</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691437.1">
        <property type="nucleotide sequence ID" value="XM_006691374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S085"/>
    <dbReference type="GeneID" id="18254951"/>
    <dbReference type="KEGG" id="cthr:CTHT_0009130"/>
    <dbReference type="eggNOG" id="ENOG502RMH0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_832043_0_0_1"/>
    <dbReference type="OMA" id="HEAPLMT"/>
    <dbReference type="OrthoDB" id="1678912at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="19"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="346" mass="38009" checksum="FCE33128BD602B64" modified="2011-10-19" version="1">MHTLDPPAKYYKTAPKDAPAIRVGFVSPSVGYGLFAARDFEKDEFIFHEAPLMTALFNEKFSEDKALMRSQACAYRAALTAHRDVTTIAFPVLAARFGIAPMPYDQAADVLALHLGRNLVPGHGRFAGSTVTREQYEAYTGSLPVANDPSERDIRYACLDFFKNYAFEVHHSTPGNSLIAATREACVYLLGSLINHCCTPSPPLIPKPRLSLHHKDHHRHRCRNRNSNVNPHSGTNGKPASFISSLSSTVASSAPSSSSSSSTTSSCDNDYENPELLGPNCTWRIGPSGLANFVRPRHLCVQARRRIRAGEQLTWDYGKREKGFECECDTCRAGFLAGLGHHCGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0H5</accession>
    <name>G0S0H5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0010040</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691527.1">
        <property type="nucleotide sequence ID" value="XM_006691464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0H5"/>
    <dbReference type="STRING" id="759272.G0S0H5"/>
    <dbReference type="GeneID" id="18255042"/>
    <dbReference type="KEGG" id="cthr:CTHT_0010040"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_518744_0_0_1"/>
    <dbReference type="OMA" id="NILCEYP"/>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF24">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="166"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="199"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="16"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="225"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="473"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="290"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="477"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="501"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS23336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="525" mass="58043" checksum="5A79456207F7845B" modified="2011-10-19" version="1">MSDKQPRKKIIVTYWPKGSRIRVVDASSIEENTEQGSSVRTPVSPAESGDEAESKNKNDSEDKTKSSEKTKSNGNETQSPRPTTLARLFRTPLPTSRTFTPINSNGGQGTSSASSSRMNLRSAQGGQTATPSKAEPKKGEMENQQQPSRAVNGQRDTAAPKQKKRYPCKYAQKLNCDKTFTTSGHASRHSKIHLGVKNILCEYPGCTKKFTRNDNMKQHYKTHFRNETNQTGTTTRSARASITVNSRRASTDSSVTQTTTTSRVSSGSLAPSTTPGSVLPTPRISNPLRTASPSSPSTALTSPASFHSPLVRPSQRSHSSGNVNDNDNKEYFPKLYGDIPPERRLPAISEIQRPGSWTTALPPLRIPEGRPGQPPQLVQGHGYHGYYGYQPREPEPAHGYIGFRPREPENWQPVGWGTPAFLLTQTQRARSPSPSDRLLTVPDRLRHLMPVNRPANGLDMLIAACEEVNQMRKREWEEESGGEDNNEDNGDENQRGKRRKMNGEAADKDKQPEWNNDSDGDIVMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0L9</accession>
    <name>G0S0L9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative actin binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0010480</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the actin-binding proteins ADF family. Coactosin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691571.1">
        <property type="nucleotide sequence ID" value="XM_006691508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0L9"/>
    <dbReference type="STRING" id="759272.G0S0L9"/>
    <dbReference type="GeneID" id="18255086"/>
    <dbReference type="KEGG" id="cthr:CTHT_0010480"/>
    <dbReference type="eggNOG" id="KOG3655">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_826394_0_0_1"/>
    <dbReference type="OrthoDB" id="20822at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11282">
        <property type="entry name" value="ADF_coactosin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000018">
        <property type="entry name" value="Coactosin-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF56">
        <property type="entry name" value="ADF-H DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="6">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS22579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="336" mass="37068" checksum="6740789065CB34B9" modified="2011-10-19" version="1">MSGADAPEILAAYDAVRSDKDPTNWLLISYAGPTGNQLVLSKTGTGGLAELKEEFVDNDVQYGYCRVEYANDAESKRIKFVLIVWIGEKTKVMRKARVSIEAGNVKKVLSHYSVQVDASEKRDLDENDIVARLRKAGGADYNGGRCLARTDGFHVGDRHCGFDAQYNTAFTGQRQVLVFDDHSHEWIRICNAVGKRKVGADRWKNVARPSHQDTLAAPKTRGRDLATQNQRQTKLGPYNAVIHDAGIFRVTTGGVDTSALCKSGPPTTITVNMLALYLLICLMIRQKRLICISDLHKGGRLNLRPHQDERIAGLRSFGGCCVEAFTMLALGWGESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0U2</accession>
    <name>G0S0U2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0011240</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691644.1">
        <property type="nucleotide sequence ID" value="XM_006691581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0U2"/>
    <dbReference type="STRING" id="759272.G0S0U2"/>
    <dbReference type="GeneID" id="18255162"/>
    <dbReference type="KEGG" id="cthr:CTHT_0011240"/>
    <dbReference type="eggNOG" id="ENOG502SP4B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_879997_0_0_1"/>
    <dbReference type="OMA" id="PNEENCA"/>
    <dbReference type="OrthoDB" id="3508416at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="35900" checksum="10A7399FB5FB6C89" modified="2011-10-19" version="1">MPSYYSRGRVPAGNAQDIVDGLDQRSSQAAKPAQSSQSPYPIGQPVQSPGSAMQQRAISQFLKPSHMITPEYRIRRDNPTIQDVIDRIVAGFSANYRGDILAQANKAAKIPDDENCSVWMSGLPPNVTYAELLSSIRDAGRVWASHIRPATDKYPTPGAKVTFMTPKAAKTLIERQYLFIRDRYVRVQYDRNKVSKPQVPKGHTRVLWIYGPKEIVNLEFLNDLFARTCQFQTEHAELLCKGQVINIIEWKFSSYRCQAQWIYLGLKNLADLGIDVKFMIDPCDTFEENDDGNGKDCVEEEERSGEERLDEHFLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G0S175</accession>
    <name>G0S175_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0012600</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691777.1">
        <property type="nucleotide sequence ID" value="XM_006691714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S175"/>
    <dbReference type="GeneID" id="18255298"/>
    <dbReference type="KEGG" id="cthr:CTHT_0012600"/>
    <dbReference type="eggNOG" id="ENOG502T1M6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085413_0_0_1"/>
    <dbReference type="OrthoDB" id="4576642at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="284" mass="32175" checksum="B0F17698D81F3493" modified="2011-10-19" version="1">MLRRTLTRLMSLQHSHSIPSTSSSSSSSSSSSSSSSSSSSFSITSTSTSSPYSTTSSDLTLETLRKITQTTTVLPPAPTSWQEPFTPSPRVASFAAQNNLAFSNALRMFPGQNVQSMPLRISLCPKRAFNFYHQRYFEQYEHPLTEKTLHFYEEEMKKKPLWCYVHCSGADGSNTVVRTAARRYLTKVLAQALEREGYELSGRSLKPGEKELRGTIQVVVTEGKTLLNMDGKKLEEYVGLLVRKDIVPRLSGRLHQMNQEYERGKRQQPRDRQRSQQRGNRPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1R1</accession>
    <name>G0S1R1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ectonucleotide pyrophosphatase/phosphodiesterase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0014500</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691963.1">
        <property type="nucleotide sequence ID" value="XM_006691900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1R1"/>
    <dbReference type="STRING" id="759272.G0S1R1"/>
    <dbReference type="GeneID" id="18255488"/>
    <dbReference type="KEGG" id="cthr:CTHT_0014500"/>
    <dbReference type="eggNOG" id="KOG2645">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017594_4_0_1"/>
    <dbReference type="OMA" id="DGHKFGP"/>
    <dbReference type="OrthoDB" id="415411at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009141">
        <property type="term" value="P:nucleoside triphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16018">
        <property type="entry name" value="Enpp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.180:FF:000003">
        <property type="entry name" value="Type I phosphodiesterase/nucleotide pyrophosphatase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF120">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="713"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="768"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="676"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="726"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="796" mass="88705" checksum="595DCD04E9AC19EF" modified="2011-10-19" version="1">MPLEPLKLTAPAAGVGVGRDPALLLSPSEYDADAVSIRSDQDTDSEDDERQLRARNSRELLAHDRLVLMEEEELDQLVIEARREQARERRGSGLPIPNPLRLLTRRLSDASTVRNRSRSPSAQPPAPSIHDSAEDLRLEKRRARRARRKAKRDRLFADARHGEDGELMYEMEEGGMKEGSETGSSSDREDSDELDRRNLLHRADLKARRSCRCRAWALVYAIIGVAFSILVLVAWKLSTGTKSSRLSQNLVSNGTALFAPTTILISLDGFRADFLQRGLTPNLDALVKSGVSPPYMLPSFPSVTFPNHHTIATGLYPESHGIVGNTFWDPVLQAEFYYTDPARSRDPKWWKGEPFWVTAQKQGLKTAIHMWQGSQSHIQGVEPTYVDPYNGRMDLLAKADRILEFLDKPDPDRPQIVAAYVPNVDSDGHKYGPNSTEIRSTLRKVDKMFERLLFGLDQRNLTNIVNIIVVSDHGMATTDVSRLIQLEDIVDLSKFDHIDGWPLIGLRPKNPNELQAIYNQVIQKTKDNPNLDVYLRDVNMPERYHFSHNERIAPLWIIPKAGWALVKMDEMNVKEAQAKGETYHPRGLHGYDHEHPLMRAIFIARGPAFPHPPNSRLNPFQNIEVYNLLCDSVGIVPAPNNGTLRLPLRPVGLHSDPDAAKPETPSDPPATTRSASNSPPSVSPTHVPTTTKTILVNPVVSDSPQSLTHPITTIKSVGVDPPIPEPTSSQPQEGGETNSSGDGKSFVNKVESSVKDFWDWFTGKVSSWWDKVTGPADQGRSNSSGAEPSQDGKSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2H1</accession>
    <name>G0S2H1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0017210</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692223.1">
        <property type="nucleotide sequence ID" value="XM_006692160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2H1"/>
    <dbReference type="STRING" id="759272.G0S2H1"/>
    <dbReference type="GeneID" id="18255759"/>
    <dbReference type="KEGG" id="cthr:CTHT_0017210"/>
    <dbReference type="eggNOG" id="ENOG502SYMB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057878_0_0_1"/>
    <dbReference type="OrthoDB" id="5211263at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="399" mass="43390" checksum="879069534AF27C79" modified="2011-10-19" version="1">MATPAAIDLDQVLYARARWRKTILIPLWTFQMLVLLCLMGLFAYRLAETFDNWEQEIAEGKVPVVEVVWEATNVGFNTIALILNIIEISRKATECLTPFLMVCTHILKLTLSFAVLALDIVAVREKMDNHYSTIGLSLDCGLLAATLSSFVYAVHTYRRLLKYEDYHLTANARQQLYGQLAEDRSSTQLGGRRVSKFYNRTYTTEYHEDYADSFYTRTEYPSQLSRVSRQSLTYSPYSSSIPQQAPDPVPPPSLTGEELKRQIDRALGSEFGWDSNTAAAAAAVAIATREVSPTSSDGQLPPTPSTTTAVTATTTGGTPGTTSVMIPTPTSSVAPSIAAAGAASGSRRRSGSVVVGSGMAPVRHVHSESVDDGGVRVDKSKSAEVVFDRGQEGGEVSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2I8</accession>
    <name>G0S2I8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar protein sorting-associated protein 74</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0017380</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Mediates the cis and medial Golgi localization of mannosyltransferases through direct binding of their cytosolic domains. Involved in vacuolar protein sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">Golgi stack membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GOLPH3/VPS74 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692240.1">
        <property type="nucleotide sequence ID" value="XM_006692177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2I8"/>
    <dbReference type="STRING" id="759272.G0S2I8"/>
    <dbReference type="GeneID" id="18255776"/>
    <dbReference type="KEGG" id="cthr:CTHT_0017380"/>
    <dbReference type="eggNOG" id="KOG3983">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036311_1_1_1"/>
    <dbReference type="OMA" id="GETWNLL"/>
    <dbReference type="OrthoDB" id="2189106at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048194">
        <property type="term" value="P:Golgi vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3630.10:FF:000002">
        <property type="entry name" value="Vacuolar sorting-associated 74 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="entry name" value="yeast vps74-n-term truncation variant domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704:SF2">
        <property type="entry name" value="GOLGI PHOSPHOPROTEIN 3 HOMOLOG SAURON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704">
        <property type="entry name" value="TRANS-GOLGI PROTEIN GMX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS22221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="350" mass="39125" checksum="2889801D212F02F9" modified="2011-10-19" version="1">MATTTTSGLTRRRGAGGGGAGSGAGSGADEERRATPSIGPPITSYENGESGHRIAYDPHDISESAERSKQPKLTLMEEVLLLGLKDKQGYLSFWNDNISYALRGCIVLELAFRGRIAMQKNPSRRSFPLPDRIIEVIDDTLTGEVLLDEALKMMKTSEKMSVSNWIDLMSGETWNLMKIGYQLKQVRERLAKGLVDKGILRTEKRNFLLFDMATHPVVDTGAKEDIRRRVRNVLTQRTVVLNPSQWLPEGLEFRYLRTVAMVCAAYAANVLENALSTLGHEARERAFNQTDELLADYSQWPFGRKAVHNEIGENLPQVIAEEVNKYPERELQLEVVAACLAVFTRLDSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2M6</accession>
    <name>G0S2M6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0017780</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692278.1">
        <property type="nucleotide sequence ID" value="XM_006692215.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S2M6"/>
    <dbReference type="GeneID" id="18255816"/>
    <dbReference type="KEGG" id="cthr:CTHT_0017780"/>
    <dbReference type="eggNOG" id="KOG2806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001837_4_0_1"/>
    <dbReference type="OMA" id="FARIVSM"/>
    <dbReference type="OrthoDB" id="4364812at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF402">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="GH18" evidence="13">
        <location>
            <begin position="1"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1225"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1818"/>
            <end position="1842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1227"/>
            <end position="1244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS22259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1842" mass="210130" checksum="543DD8917D07A215" modified="2011-10-19" version="1">MASRHNSRENFVKNVVNFLRQYGLDGVDIDWEYPAAFDRGGTPADEDNYVLLLSQMRQAFDREGAGWEISIAIPSSYWYLKGFALERLQRYVDYFNFMSYDIYGMWDRDNKWTGPYLKGHTDWSMIELGLDLLWRNGVEPKKVNMGFGFYGRSFTMENPSCFEPNGICKFSDGGNPGSCSNTKGVLTYEEIASRNHSLDVVTIYEGKETTVKYNVYGVNQWVSYDDAQSFHDKLEHLTSRCLGGLMIWAIDQDTSDFKAFGELMGDYAHLNLHGLDADSAEELSDLFGQYNGQHCYVTERCTKDRDLNSGDTVHEGEKCDPGYESVAKAHNPIQKYPRKLYDKCEKGWYRHICCPKKQLPKECKWIGAPERNRHGCIGECGGGTFELNSDDAVDPYGNQLCYQGRRKLCCRSTKLFDDCFWTKCSQTPYASDDHPDCPDGTEYVTWRNDKPDGSGGMCQEEYGTRGSPLKSPFRSSLCCPKGQRLWEEYFNNKEKDKAVWSYDTQFEHNDMDKHRASLDVIDGSDAFGFLMLNGPQEAIDDSFHKTMTIVRRNAQIPKVKREIFTKNKTLIDKVFEHAAETFYAYCNYPAGSPECERLFLGGAEDTIISLPAHVGEGPFARVVSIQKVSEEDHKILIPRHHFEHRSKERLNDNPLWKIKIDYNFHLARQDRGKVKIRVDYSNLLGYWKEITDSPAERRRKRNFDPLPGEPGFKVEHFRKMVARGEEYDRIIGRRSQKTVKRTMSLKDSELEPNGHLSTSTVPLDFSYSKRSSHGKRWWGAFKEWLRKLTTVTKDELGDLPLSWSKSVNLFKASAGCPQRTWNANLRVDLNAEVSMQATYAYYMSATFIPPSKPDVFFYFGVEPTAALELVMVGNAAARLRTGQKKIVDTLSYPGLAIKGIAAVGPTLDVYGEIKGEINLHGKALAGCRVTLEKTQVYWPQDDKEIDKYDKILGINLRDKEVPKGNKIEPSFEAGVELKAEVDVIVQPQANVGIKVGGGSYTGGTSLVDAEISAYVFTALQFLATGVASTVTKTFNYTYGVYLHWNVGYKAVASILDWVSWATQPREAYPKPRVIRIYQKHGSIDLSRPGGGFIDRRTLDSLTLHSTFKYSNETLAQATSPLDSALSMRRRQNDDDGDPMDIDSPASPTFSQTQLTCPAGGSPSIKIPELRLNCAALPPLSVSLPGNKKFRMSTVCDGYKSGNIQLPMTLTHASVISEDSMMRKKQRRNEACKNNDPEPDGLHRDRKSCKEMNEELYKAGFPRPVHSTVQVLECDEFPWAASEEGGSFMPVNERSRLCVPRVQNNYAGQCVDLLNDMQSNVGKMEPIDPPKGQERPNLWAYWGGKQNANVKIWYTTDVINGVQNRMTTYSTRQPIPVGYLPKTWKGNDKTSWVFKRNYTFSIVDDGSDAKSWWDATRYKVTKAGEQLADPNSYQSILCAVNIFGQTDYYKYPEKNGEKWNGLCLTSPRGRRQEWDDQWGLSRCLVEFGKSHDVKRSVGDEEATEWAVKSIRADQSLTMSSISQESIEVTPPWGSLPVEQYLIRNWDHSSNMTADEQRKKVVAAFVDEDLLDEDLFAFPPTRTPTESEITEILAPWRPQKLRHIAAAHARIPGFFPTDFSPFYYIVRTYYDGGAEDDVKFRKWLDDSDEDWGHCIPREHEWFCVLNDPELFNYGDDHWTRVYEVLPELASRGPDCRFTEEHIIWGLSWGQSYRDSEEYSSDEENLAEGIRAAASRDEPWLVVFDLDAFKEERARLVYRDRKGYPIKETVLGMPEGYEDFRGRCSRGATFEGYWEHAVVANMYERKGKIMKKLLPLVKEAEEKERAEEKEGKEMQDQTKEEKVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2N7</accession>
    <name>G0S2N7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Autophagy-related protein 28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0017890</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692289.1">
        <property type="nucleotide sequence ID" value="XM_006692226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2N7"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015530_1_0_1"/>
    <dbReference type="OMA" id="HWNLLIC"/>
    <dbReference type="OrthoDB" id="5342758at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="201"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="503"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="610"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="660"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
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            <begin position="349"/>
            <end position="383"/>
        </location>
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        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="503"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="528"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="612"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="637"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGS22270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="746" mass="80844" checksum="40F2FA79F3B4D59D" modified="2011-10-19" version="1">MTSRSSFLPRLGFGRTDNNPLLPLHSLSSSVRKKPSEYNLAELSPRPDDGSNKTRMSPPPVRRRSPPPPSSTRGRDESTSHRSHLASSRPHRDRDFDQPILFAGPPPPIATSRMLYLDEEATESTSSRGGGGLGASLFTQNLGSVLFNRGSGASSPSVPRDNKDYYHDYTLDATWLTFQRRERALQEDLQQMLDAQSAGLAANLDPNNPTLNPSFNSNASSTSPAPPSRSSVVSDRSTPRTPPSSGNRARHVTFDPVPHTAMDLGTILPVRQPKPKAITLRAARAGLTRTIGLLADLKADEDAQIVTALGERKKALARLRGLSARREGIVEKLRVLEQDDEEGKEGEGEGKGEGEIKNLEARLAELKKRKAWLDARVEEVRSRREAGLSGYRGALREVEDKIGGLLSRPGVKPLDLRVVKAWGFGEEGVWEDPGGADFLKLRPERRTVQMAREWWEGEVAILERRKQDVDRERAALEEGVEVWKEAVKLVTDFEDGLMREMKGEEEGRPFGEDDRFGNQQRSSKGKGKASPSGGIAGTSELSSPSLAPARSPEQAMRNQLAKIHTVMAGLEERLHVAEEKGWKLLICAIGAELEAFRQAEGLLRDALRAAGFDDDSPDGDGGPDEGNDGREVPGIGSTRSSRPPTAIRSSSAQLLAGLESGPGVSTAVEGNDAGIKRGKNGSLADVAVETAGRDDKAAESDNEVPHDLLVSAVEEPSMASEASENEVPIEFLRVHGDYGGLGIRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2P6</accession>
    <name>G0S2P6_CHATD</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="3" type="ORF">CTHT_0018000</name>
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        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
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    <dbReference type="KEGG" id="cthr:CTHT_0018000"/>
    <dbReference type="HOGENOM" id="CLU_924385_0_0_1"/>
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    </dbReference>
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        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="111"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="235"/>
        </location>
    </feature>
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            <begin position="248"/>
            <end position="282"/>
        </location>
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            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
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        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
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        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="301" mass="33500" checksum="BB9AE0E2F9A3A821" modified="2011-10-19" version="1">MRGVLSRDVLHAIRNLSLFSSSDSWSQPIKEDNFEINQSEVVNLNDPTLNVNLDFTSREDAPLERGHFSRPQEGSGGGNVEKNLEGNLERMVGKPIITKLHSFLIQTSLAQGGSSSPLSSPQPARTPENPAESRTVPGSSPSAAANGIYKHPYYCEDFSPSDSTTWLLPSNPSQEVVESSHVADSFSVLRTVRFQKVARQTRHHRVRLQQRQQHQRSSHGFTPAARSRDGSGTTLSVGGVPMDLLHTVHRLKGELAQLRQEAQQAKADVTKLQRERQRMHDEVTKLHKGDQCLRNEIAQLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0S371</accession>
    <name>G0S371_CHATD</name>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">CTHT_0019920</name>
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        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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    <dbReference type="OMA" id="MGIWESS"/>
    <dbReference type="OrthoDB" id="3526284at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <location>
            <begin position="235"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="306" mass="34079" checksum="E2644A336C44A3E2" modified="2011-10-19" version="1">MGTSDDLPPSYNEAISGVDSKVRPSTSSVFWSPLSNHIRALPELLRQTIAARKTSQDVRDANTIMLMLPSVEDFLSRLSSGRLLDCFGNIPRISELTLVPAVAVPEGWELTGARERVLEGEVVEVSRVEDPAHTKDGKSSRQRPHRPKLISTLRDEVDETIDEWGWFETEELGDGKGFSGDPLWWDDEEMAKRLAKRLQPEPDLDRKKVHAIVIERKTATREEKLGWIARLGFGGSKSKKADRDQVSTTTLPSTPTSAPDSAEASSSPVKMIAKVGEVTFRKENQFGVWESRTGWGVVITIMISER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3H4</accession>
    <name>G0S3H4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acyltransferase MbtK/IucB-like conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0021050</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lysine N-acyltransferase MbtK family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692576.1">
        <property type="nucleotide sequence ID" value="XM_006692513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3H4"/>
    <dbReference type="STRING" id="759272.G0S3H4"/>
    <dbReference type="GeneID" id="18256143"/>
    <dbReference type="KEGG" id="cthr:CTHT_0021050"/>
    <dbReference type="eggNOG" id="ENOG502RZMI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027095_1_0_1"/>
    <dbReference type="OMA" id="FPHKQSW"/>
    <dbReference type="OrthoDB" id="448427at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31438">
        <property type="entry name" value="LYSINE N-ACYLTRANSFERASE C17G9.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31438:SF1">
        <property type="entry name" value="LYSINE N-ACYLTRANSFERASE C17G9.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13523">
        <property type="entry name" value="Acetyltransf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="55594" checksum="D5D4C264FD6CF321" modified="2011-10-19" version="1">MSPEVIHLPNGQNITVTPVFAGLFFKSNEPTTHPGVFPIGWTIVIHTEGGIVETEDGVSAFDSPHQGPDQGPRPDSKTQLHTFTRPTLQNDSLFISSISNPSNQDYKPAASPTRQIAMMLWVTLYWYFHQPPPPATVTTEASRLTPQAGRPRGEWRVRIKRDGVLRGHDLMAKLERMGLIASCDSSVGTSLQDTEETWANMFVTQKMFWQIPGRLFLFSRQPVMKSNISYPNSPTQSRPESPTQGEFLSQNTAVDAEGLQALGAPPTSNSSIPPFLLGPFYSGSYLPTYYPPPPLQYTITNHVRHPLRPKPPRMGEVFYTRFIPSIGQYLSFRVASLSPNPVPYMGPIGSKPPPQQHLCTMSDTTLLKAWFSSPRVTAFWGDYSPTFLTNALQSRHSFPVIGLWDGVPFGYFEIYWVKEDLLGRYAGSSIDDWDRGLHVLIGEEWARGRVQPWLTSLVHWMLCADYRTMSICVEPRVDNARSVHTPKRKRPEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3J8</accession>
    <name>G0S3J8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0021510</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Mol. Cell" volume="81" first="1781" last="1788.e4">
            <title>Mediator structure and conformation change.</title>
            <authorList>
                <person name="Zhang H."/>
                <person name="Chen D.H."/>
                <person name="Mattoo R.U.H."/>
                <person name="Bushnell D.A."/>
                <person name="Wang Y."/>
                <person name="Yuan C."/>
                <person name="Wang L."/>
                <person name="Wang C."/>
                <person name="Davis R.E."/>
                <person name="Nie Y."/>
                <person name="Kornberg R.D."/>
            </authorList>
            <dbReference type="PubMed" id="33571424"/>
            <dbReference type="DOI" id="10.1016/j.molcel.2021.01.022"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (4.20 ANGSTROMS) OF 1-77 AND 79-168</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 22 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692621.1">
        <property type="nucleotide sequence ID" value="XM_006692558.1"/>
    </dbReference>
    <dbReference type="PDB" id="6XP5">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.20 A"/>
        <property type="chains" value="V=1-77, V=79-168"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3J8"/>
    <dbReference type="EMDB" id="EMD-22284"/>
    <dbReference type="SMR" id="G0S3J8"/>
    <dbReference type="STRING" id="759272.G0S3J8"/>
    <dbReference type="GeneID" id="18256189"/>
    <dbReference type="KEGG" id="cthr:CTHT_0021510"/>
    <dbReference type="eggNOG" id="ENOG502SD63">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1586278_0_0_1"/>
    <dbReference type="OMA" id="YRDLMNC"/>
    <dbReference type="OrthoDB" id="203279at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.160">
        <property type="entry name" value="Mediator of RNA polymerase II transcription subunit 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009332">
        <property type="entry name" value="Med22"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06179">
        <property type="entry name" value="Med22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8" id="KW-0002">3D-structure</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS20325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="6XP5"/>
        </source>
    </evidence>
    <sequence length="168" mass="18249" checksum="67033A04EC153304" modified="2011-10-19" version="1">MDRDQGASDNLLERKNILIASIMTSYRDLITHATSPITSATASPGHAGYSSMALSTAIHAAVKYTEDLLSLTRTLRELWVVGPLTGPGEKDAQAEEGMAKDAEVVWDVLNEMRDRERERMMAALMEGDTRVRGAVRFERGDVEVVVAGQGQQIEMGRGVNGEVKSEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3R3</accession>
    <name>G0S3R3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0030330</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693485.1">
        <property type="nucleotide sequence ID" value="XM_006693422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3R3"/>
    <dbReference type="GeneID" id="18257071"/>
    <dbReference type="KEGG" id="cthr:CTHT_0030330"/>
    <dbReference type="eggNOG" id="KOG3947">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041441_3_0_1"/>
    <dbReference type="OMA" id="PHHDAWS"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF0">
        <property type="entry name" value="CALCINEURIN-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="76"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="266" mass="29799" checksum="77F33A51F8110677" modified="2011-10-19" version="1">MPLTLQLRRTSPWDPPTPLDHLLTSPIQGLTSFFYHRILLPLQGTPAGVRYYHYYYPSVVHNRVSSPKPDHGGDKIRIVCLSDTHTNTLKEGGIPEGDVLIHAGDLTNEGTPEEINAQLDWLRGLPHQWKVVVGGNHDSGFDPGTGATHLDLSLGCPSLLRELWRVRPRLHVFGHVHAAHGTEVVWYDACQREYERLMLRPAKGLLWDLIPSMKWVESLSVVWYGVLSIVRRWFGGSRQGGLLVNAAVMYRDSGVLGNPVTVVELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3X5</accession>
    <name>G0S3X5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 14">DNA replication licensing factor MCM6</fullName>
            <ecNumber evidence="3 14">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CTHT_0039220</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 14"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS22037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694333.1">
        <property type="nucleotide sequence ID" value="XM_006694270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3X5"/>
    <dbReference type="STRING" id="759272.G0S3X5"/>
    <dbReference type="GeneID" id="18257960"/>
    <dbReference type="KEGG" id="cthr:CTHT_0039220"/>
    <dbReference type="eggNOG" id="KOG0480">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000995_3_1_1"/>
    <dbReference type="OMA" id="RHQQTDK"/>
    <dbReference type="OrthoDB" id="1744952at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990518">
        <property type="term" value="F:single-stranded 3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902969">
        <property type="term" value="P:mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17757">
        <property type="entry name" value="MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.870:FF:000002">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000115">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008049">
        <property type="entry name" value="MCM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041024">
        <property type="entry name" value="Mcm6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF43">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18263">
        <property type="entry name" value="WHD_MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01662">
        <property type="entry name" value="MCMPROTEIN6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 14" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="16">
        <location>
            <begin position="489"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="807"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="807"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="852"/>
            <end position="863"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGS22037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="982" mass="107154" checksum="A748750187D6041A" modified="2011-10-19" version="1">MPSSEAGFLTSDGPARTPRARIPPSSSSVRAAAGPALQSESVAGISDGEADAEAFVDDQVPSRTRPVDPANIPKVEDKIGLLVQENFENFIENFTEPTTAASASQQQQGQGPTSSAQPAVTTDKYYVAQIKGMRVYQLSTFYVDWKHLESWNNGHLAQGIMESYYRFLPFLTQALHNMIAKYEPKYFREHRQPGTTVSSQIGGSSAASNAGSASQVEINAKTAHQQTDKLFSLAFYNLPLVSRIRSLRARNIGQLLSISGTVTRTSEVRPELASATFICEACYAVVPDVEQTFRYTEPTQCPNATCLNRTAWRLDIRRSTFVDWQKVRVQENASEIPTGSMPRTIDVILRGEMVDRAKAGEKCIFTGALIVVPDVSQLGLPGLRRVAVRDDRGATGAAEAGGAGVTGLKALGVRDLTYRLAFLACMVTPDVSTLGASGEAQIVDVVGSLTAGAAVETAETVKELQEAVLASYTKEEIDDLRAMVHSDRIYSRLVQSIAPMIYGHEIVKKGILLQLLGGVTKTTPEGMQLRGDINICIVGDPSTSKSQFLKYVCSFAPRAVYTSGKASSAAGLTAAVVKDEETGEFTIEAGALMLADNGICCIDEFDKMDVADQVAIHEAMEQQTISIAKAGIQATLNARTSILAAANPVGGRYNRKTTLRANINMSAPIMSRFDLFFVILDECNEQVDRHLAEHIVAIHQHRDNAVQPEFSTEQLQRYIRFARTFRPEFTDEAKEVLVQRYKDLRADDAQGGAGRNSYRITVRQLESMIRLSEAIAKANCVEDITPEFVNEAYHLLRQSIISVEHDDVEVEDEEPEDSQDALRQAAAAAAGEAPITDGDGDQAMADEPPAQTEGQQRQSKKQTISYDKYISMVNVLVQRVAEDEASGAGEGVEADALVEWYLEQKESEIQSEEEYHAEKALARKVLKKMVKDKANSSQDNILMEIRGQGMTADDEDNAGEGSSAQAQKVVYVLHPNCAVEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3Y4</accession>
    <name>G0S3Y4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative pyridoxal phosphate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0039310</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS22046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694342.1">
        <property type="nucleotide sequence ID" value="XM_006694279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3Y4"/>
    <dbReference type="STRING" id="759272.G0S3Y4"/>
    <dbReference type="GeneID" id="18257969"/>
    <dbReference type="KEGG" id="cthr:CTHT_0039310"/>
    <dbReference type="eggNOG" id="KOG0634">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_0_6_1"/>
    <dbReference type="OMA" id="ARVFVCQ"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42858">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42858:SF1">
        <property type="entry name" value="LD15494P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="1">
        <location>
            <begin position="113"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="521" mass="57946" checksum="7DB91DB719F956ED" modified="2011-10-19" version="1">MTEIRPSSQFKNEHQPTKTKHLINLLRGWPAPSLLPTHLIQAKANEVLSDPAIAISALQYAPDPGYQPLREALAEYLCKVYPSLDEFESAGQPRTFSSSEEECSASIKDVWEAENFAITGGASQSIACVLQSFTDPGYTRGIIISAPCYFLGCPIFEDAGFVGRLYAVREDKEDGMDLERLRWLLEGEDGRGSGDFVGEVRYKNPGKDRKIYRYVIYLVATSANPSGKTMSVEKRRRMVELARKHDALIISDDVYDFLQWTTADKISATNMKQRNIRPLPTLSQIDIALGRSPHDPPGKHFGHAISNASFSKLAGPGMRTGWIHGTKDFVHGFSVTGTNRSGGAASQFAAAILAKMLQSGELPAWIDGVVKPALQERYQLIMKAIKEELPDIVEVWNGNGPNGVSGDVSVFGGYFVWLTFPETIDTERLAQRAREEENLIIAPGTLFEVKGDEKNGGFRNNVRLCFSWEDKKNIVEGIKRLARVLGRILKDDDDLIHSDTAKIGMAREYKQLQEQELRDSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0S435</accession>
    <name>G0S435_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosome subunit biogenesis protein NIP7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0022410</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="11 12 13" key="2">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e56910" last="e56910">
            <title>Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation during pre-60S biogenesis.</title>
            <authorList>
                <person name="Lau B."/>
                <person name="Huang Z."/>
                <person name="Kellner N."/>
                <person name="Niu S."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
                <person name="Cheng J."/>
            </authorList>
            <dbReference type="PubMed" id="37129998"/>
            <dbReference type="DOI" id="10.15252/embr.202356910"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <comment type="function">
        <text evidence="6 7">Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with pre-ribosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NIP7 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692707.1">
        <property type="nucleotide sequence ID" value="XM_006692644.1"/>
    </dbReference>
    <dbReference type="PDB" id="8I9R">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="CG=1-184"/>
    </dbReference>
    <dbReference type="PDB" id="8I9T">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.60 A"/>
        <property type="chains" value="CG=1-184"/>
    </dbReference>
    <dbReference type="PDB" id="8I9V">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="CG=1-184"/>
    </dbReference>
    <dbReference type="PDB" id="8I9W">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="CG=1-184"/>
    </dbReference>
    <dbReference type="PDB" id="8I9X">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="CG=1-184"/>
    </dbReference>
    <dbReference type="PDB" id="8I9Y">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="CG=1-184"/>
    </dbReference>
    <dbReference type="PDB" id="8I9Z">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="CG=1-184"/>
    </dbReference>
    <dbReference type="PDB" id="8IA0">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="CG=1-184"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S435"/>
    <dbReference type="EMDB" id="EMD-35281"/>
    <dbReference type="EMDB" id="EMD-35283"/>
    <dbReference type="EMDB" id="EMD-35285"/>
    <dbReference type="EMDB" id="EMD-35286"/>
    <dbReference type="EMDB" id="EMD-35287"/>
    <dbReference type="EMDB" id="EMD-35288"/>
    <dbReference type="EMDB" id="EMD-35289"/>
    <dbReference type="EMDB" id="EMD-35290"/>
    <dbReference type="SMR" id="G0S435"/>
    <dbReference type="STRING" id="759272.G0S435"/>
    <dbReference type="GeneID" id="18256279"/>
    <dbReference type="KEGG" id="cthr:CTHT_0022410"/>
    <dbReference type="eggNOG" id="KOG3492">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097217_0_0_1"/>
    <dbReference type="OMA" id="LISMGTC"/>
    <dbReference type="OrthoDB" id="27490at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21146">
        <property type="entry name" value="Nip7_N_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21151">
        <property type="entry name" value="PUA_Nip7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.10:FF:000002">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.220:FF:000001">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040598">
        <property type="entry name" value="NIP7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055359">
        <property type="entry name" value="Nip7_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016686">
        <property type="entry name" value="Ribosomal_synth_fac_NIP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005155">
        <property type="entry name" value="UPF0113_PUA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17833">
        <property type="entry name" value="pre-PUA_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03657">
        <property type="entry name" value="UPF0113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017190">
        <property type="entry name" value="Rbsml_synth_fac_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88802">
        <property type="entry name" value="Pre-PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="11 12 13" id="KW-0002">3D-structure</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUA" evidence="8">
        <location>
            <begin position="96"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS20411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="8I9R"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="8I9T"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="8I9V"/>
        </source>
    </evidence>
    <sequence length="184" mass="20658" checksum="A6DBCEEA5F5E71CB" modified="2011-10-19" version="1">MRPLTDQEMKIVLDKLANYMTDLKSLIAPLEDGDRYVFRMQKDRVYYVKLSIANIATCVARDKLLSLGTCLGKMTKSGKFRLHITALPILAQNARYKIWVKDNGAQPFLYGSNIVKAHVGRWTEDCPEHSGCVVYNMADIPLGFGVTARSTAEARRLDPTGIVCFRQADCGEYLRDEDTLFTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4W1</accession>
    <name>G0S4W1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidyl synthase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0031870</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693628.1">
        <property type="nucleotide sequence ID" value="XM_006693565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4W1"/>
    <dbReference type="STRING" id="759272.G0S4W1"/>
    <dbReference type="GeneID" id="18257225"/>
    <dbReference type="KEGG" id="cthr:CTHT_0031870"/>
    <dbReference type="eggNOG" id="KOG1618">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030880_3_0_1"/>
    <dbReference type="OMA" id="SWMETIH"/>
    <dbReference type="OrthoDB" id="10251048at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000069">
        <property type="entry name" value="HAD-superfamily subfamily IIA hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006353">
        <property type="entry name" value="HAD-SF_hydro_IIA_CECR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01456">
        <property type="entry name" value="CECR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF51">
        <property type="entry name" value="HYPOTHETICAL HAD-SUPERFAMILY HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="536" mass="59417" checksum="A3298009652B6C91" modified="2011-10-19" version="1">MSKPGFKDVDFGNKASQSQINTPFDSPEKVSHPRTKERPKELQLQKAKEWLDAHGSQRSPMRATGWGGLEAALAVPVSPGSHNTIEIPALRSPDADTTQFMHNLSASPSMKERRLSRNSFGATLPIPKSKRQSRLSSLAYQEGRETLKADKGAGAMPSYATREILVSQIQDIKADKVKKAKNMAFVFDIDGVLVHGDRLIPEAKRALSMLNGDNELGIKIPHIFLTNGSGKLELARTQQLSKILQNPISTDQFIQSHTPMRALAEYYNTVLVVGGEGNRCREVAEEYGFKEIIVPNDIVVWDPTIAPYRTVSEEDKAKARPLDFSKINIEAILVFSDSRDYATDMQIIVDLLRSENGRLGTMAKDPVSQRIPIYFSQGDLLCPTEHPYPRMSQGAFRIGLEAMYKALTGVELERVVYGKPELATYKYADEVIASWMDMLHGEERVPDNIYMIGDNPASDVIGGNMYGWNTCLVRTGVFQGGGNDEDNPASFGVFANVWEAVTAACRKELGDDFIFKWDEKRINPVLSSEAASAIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5A3</accession>
    <name>G0S5A3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PXA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0024100</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692872.1">
        <property type="nucleotide sequence ID" value="XM_006692809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5A3"/>
    <dbReference type="STRING" id="759272.G0S5A3"/>
    <dbReference type="GeneID" id="18256448"/>
    <dbReference type="KEGG" id="cthr:CTHT_0024100"/>
    <dbReference type="eggNOG" id="ENOG502RYEC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018250_1_0_1"/>
    <dbReference type="OrthoDB" id="5582218at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051837">
        <property type="entry name" value="SortingNexin/PXDomain-PKLike"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22999">
        <property type="entry name" value="PX SERINE/THREONINE KINASE PXK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22999:SF23">
        <property type="entry name" value="SORTING NEXIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PXA" evidence="4">
        <location>
            <begin position="153"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="613"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="779"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="54"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="438"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="655"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="689"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="711"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="785"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS20576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="917" mass="98853" checksum="A572167AE67DC7A4" modified="2011-10-19" version="1">MATTSTFGPSPGPARVSTPRPTRHARTSSIQSQTPLASKSSSRQPPGSGLGCKTSTDSGSSGSSGSGTQQSSGSSSSAQRRSTRASTTGGDRTAAIAAGADPLSDKATVFLIRRILCLGDNGKGSGGTTGGSGGGGLSSAQALEEILPPLTSRNDVDLQLYALIAIILRDFVQSWYHKITPDETFVGEIVQLIAHITRALEQRLRKVDLESLVFDEIPELLERHITAYRTAHDPITQPPVRTEPREVYHSLWPLPALSPVPRTQLGDDEDTDPDTISIARQQAENEATYRQLLVYAVLAILLPTEDLENSVLTTLVGQILSELVIGNLVANKLSEPWMIFELLIIAARNARKGVTAEFGEKESASGASLSTSSKKRRRSAAAAVEATGGTTGGGKRFSIQGLFWSIVQWCFLTMSFFRGLWTLLTMAKTLPPRTSTQRAEKLKNYEPSKPADPHKQAPKTPVLAFRCWSAILRLVELDFRMPWLHGILSMLQWAAITGPGEVGAVDGKLDRPREVSNASELLTSGRWRLLSHLLCTSALDPAKLPSILRAARAALFPGNMPAGPSSLVPPASEAEYRRLRRRCARAVYRAIAPGPGAVRSVVKTFFLGGFGFGSRSQQKNDQKKSSQHQPGRKAQGKGNDNHNKPRGRATKWEGSASTPATSSFTSSSSSTGVGEVGLGPAAWLKNGGPKKDKDRDKTKARDDKKGNNIGSSPSPSTLSSLPAKDQHQQQQRSAPGPVGLAAVSSAFPPASFPSSTTTPITSASNVAVDADASSSLLPRPAVSASAGTNTSLCASRTNNGADDDRRNGKRRLIHKPASHSQAYYYYDINRWNDCGEDEDHYVYYDDIDSDEEWDEDEQAVLREIDRSVLDVFSDAYCNKHLIYGILELVLVRLIPELAERGVGELWAERIPDVVHPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5D6</accession>
    <name>G0S5D6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin thiolesterase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0024430</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692905.1">
        <property type="nucleotide sequence ID" value="XM_006692842.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S5D6"/>
    <dbReference type="GeneID" id="18256481"/>
    <dbReference type="KEGG" id="cthr:CTHT_0024430"/>
    <dbReference type="eggNOG" id="KOG1866">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_228178_0_0_1"/>
    <dbReference type="OMA" id="FSAIQCE"/>
    <dbReference type="OrthoDB" id="420187at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02659">
        <property type="entry name" value="peptidase_C19C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000136">
        <property type="entry name" value="Ubiquitin C-terminal hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021905">
        <property type="entry name" value="DUF3517"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF827">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12030">
        <property type="entry name" value="DUF3517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="1633"/>
            <end position="1961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2451"/>
            <end position="2471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS20609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="2602" mass="292464" checksum="89387B4B53E575EA" modified="2011-10-19" version="1">MAFAASTDPPRDRAVSSEPCTTRPNPFDDGDLASRKRRRTSLNSDSRSVSVETLDTFPSPPATGKLVAAEFRPSLAMKVDSETTIPATPKEQKQSAQQDTAQQEPQPAPCARPSDSDPQQKASAQLPKSAISLPPSPSPETAVPPAASTTTTDVAQIVMEGQKAVVPAETPVVDASAQTTGAQLGSESASPPVEVVSVNTTDDDDDGDGFETDESVTLLDGVSLINDPSADFPYHEPSESPLETIIRLTAYIPTHPQVALGFAEWIDKYLGYVHAVSFRAAADSYLVHKEIWQCIPELVIFLVSRKAPYPRNRDLRQAIFSFYRAFAKLAAHFVQFDVRLLRSASVPEQQRIQYLASQQYVQALAMLSTREEIALHASTPASAERDWSYSAEVTVILDLFQRHSEVQGGSLAAVRELAQLQCEYASQYPRLTDHIGSLCLLMANMLRMFAHNQALPDRVTILSRCYTLFRTVSAMVGNIIEKNLNHLTQEGAANILNSLAEIYELCLSVGGVVPAEILKEYRQVQPPIPVYHAAEAIAHHWKFTHFVRLIKSGQMQLRVMAVSNMCNDLITIYNKYQETFGDEATDAYTHFIANFLIETGLVNYILGPTCHPEITIESSNIIGFLLVSNTYTKEHTDALWQTVTTTQDPRVSDALMRMTSRITQLYSRDGLLYLCDKLNTVPVESFGPTMREFCDAVIRTIISRNPDCLVSDARPFNLFIRLVRQASVFGAQSPVAYPEVQQFAIHKLDSLMNHGPGLEGRWTIYADCLADIEKKSPTTMGSLWVLKLATRNYHGQDLHDLITTHDLTRLLIDEFESAIAVAKNTNFPAVLSGGQNVPRRDLLSILIHQEAHAMPQGQAHPIAGEHGLRLWNMLVGSKAACKEDRDAAWQMLNSAMKQSHGRNPFTATCFSEYLPNLEPEFFCQGTLEFVCEAVLPLVNDPTSIILDDEDNPHHPMLELLWRMALAAPTGTIEAKAIHTLVNDVYIESRSIHSFPHYRARKVHLALVERCVRQLSSAAARLRAFAEGAVSSGEGDNMVIVPSEQQLREQELLFIRSLAILREFHRLHQGKPQFSVPDMRALIPETPKDIEGEPAGLKFQSFDGEKHTDVMPLNIGKRNTAASLLASLRQATGFESYRMYYRGRPFVPSESDICKSLEDLQIHNGIILVKKEPAPPTPAKPRSGASPIEAEILSHFDEFWEYLSMEESLAREIYGFLIKLPVDEKALEVIDDPSRSYLDLFPLGQPFKSLYAIYALQQYLKAPRKSGAVGNTDLTANETVQSRADGIIRVMSVLVPAISDPQVCGLCPTRELQIELGSAMMKLLLLLVKDSDLPSSATRLLDAPLLNRLVDLLAETLTASNTNNATQHVMLCLQTILESCPISAEFADAFCAHPDVPRLLEDLLLNDPRDVVRRSTAVFIRNACKLGDEELAAPDIPAAKFRNFFWPVVSRLVTPAISKPEKSTEVLNLCFDMLQALRASQSEVVQIRQLAQEWFALLMNYTTFEDATKPEVVDEVAFGLIRIIHDTILAAETRQEVLPPPGVARKIFWKHLFPPQADSEEYDSCRPIVSQQTRAMLLDIVFSSVEHDHRQYLWLLEDMASLVPMYPNQDELYSYELPQQFEREKALRGSCGYPGLRNLSNTCYFNSLFTQLFMNVDFRRFMLSATVRDPEGSQHLLYQTQRLFAYMQNTLRRYVNPEECISSVKTYDDTQIDPNIQMDVDEFYNLLCDRWEGQFATGEEKSQFRSIYGGQLVQQVRSQECEHISERLEPFLAIQCDIKGKSTLEESLQAYVDGEIMEGDNKYKCSTCDKHVDAVKRVCLKDVPDHLIFHLKRFEWNLRTMTRSKINDMFTFPNRINMRPYTIDHLSSPDDDKEEDIFELVGILVHSGTAESGHYYSYIRERPTNGNAETWVEFNDDVVTPWDPSSMATACFGGPEYNAQFQQGNTVYDKQYSAYMLFYQRSSSLSKSQELLQSTGALAPLTVSVPPHLRDVIREENNWLLRRHCLFDPTQIPFACVLLLHLKNMGGPHGGCSEDHRLETQALHMALGHLDQVASRTKETPDFLRLLGQIRIMALQCARCSLAVFRFFVDYPDALRMLVQRNVDAEVRQNSVSFIIQVLQTIKKLAPRQYIGAEGMEEESSVISGMIGILEQLFGCFQVNLRSWNEVFDLMLEFVKLGPDELAAFLEHPLFLRSLLLIVVADGLEGPLPAQFLKMLNNISRRPPARPPAYESILSLLDVLLSRIRLLYTDSGYPIGAANTRERVLKNPDFANHPFDVTKGETDILHMASRSQPVNIFVDRLIAINQNHEATDSILANLIRQSPRMEDMIMRTLATRSVGHIAQLNVTPYLRVAGSVFLREAQNASRVTTLMQQVSRECWFLQNAEGKAFLDFVRDTFEGPRPRCKQGVEQVYSLALEFVPQWAPGLLGYFDMDVVEETEQLLQEKIFQYRTFRPQPPPSKEEEEGAQDQAQPQDEIVRLLGDKMRLTARSLGFRCLLYLRDNYVQKNAEVTERAVAGLQRTIKHCSRYFNLKEPGEDPDAQKFMETNNSIQEALTKLLVVDDLEEEDASGVGVDGAAALDHLQLVGDLGVNMAVVTELHGEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5G3</accession>
    <name>G0S5G3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Synaptobrevin homolog YKT6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0032860</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2015" name="Science" volume="349" first="1111" last="1114">
            <title>A direct role for the Sec1/Munc18-family protein Vps33 as a template for SNARE assembly.</title>
            <authorList>
                <person name="Baker R.W."/>
                <person name="Jeffrey P.D."/>
                <person name="Zick M."/>
                <person name="Phillips B.P."/>
                <person name="Wickner W.T."/>
                <person name="Hughson F.M."/>
            </authorList>
            <dbReference type="PubMed" id="26339030"/>
            <dbReference type="DOI" id="10.1126/science.aac7906"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (3.10 ANGSTROMS) OF 183-212</scope>
    </reference>
    <comment type="interaction">
        <interactant intactId="EBI-16174583">
            <id>G0S5G3</id>
        </interactant>
        <interactant intactId="EBI-16063831">
            <id>G0SCM5</id>
            <label>CTHT_0057760</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>4</experiments>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693724.1">
        <property type="nucleotide sequence ID" value="XM_006693661.1"/>
    </dbReference>
    <dbReference type="PDB" id="5BV0">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="C=183-212"/>
    </dbReference>
    <dbReference type="PDBsum" id="5BV0"/>
    <dbReference type="AlphaFoldDB" id="G0S5G3"/>
    <dbReference type="SMR" id="G0S5G3"/>
    <dbReference type="DIP" id="DIP-61668N"/>
    <dbReference type="IntAct" id="G0S5G3">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S5G3"/>
    <dbReference type="GeneID" id="18257324"/>
    <dbReference type="KEGG" id="cthr:CTHT_0032860"/>
    <dbReference type="eggNOG" id="KOG0859">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064620_1_1_1"/>
    <dbReference type="OMA" id="NTKLMIM"/>
    <dbReference type="OrthoDB" id="190375at2759"/>
    <dbReference type="EvolutionaryTrace" id="G0S5G3"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000004">
        <property type="entry name" value="Vesicle-associated membrane protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051097">
        <property type="entry name" value="Synaptobrevin-like_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136">
        <property type="entry name" value="SNARE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136:SF168">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="14" id="KW-0002">3D-structure</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="155"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS21428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="5BV0"/>
        </source>
    </evidence>
    <sequence length="242" mass="27177" checksum="C5527F06FF607CF4" modified="2011-10-19" version="1">MASSSTSTPLLYACIAYETTILTETTLSPSSHASSLSSLALPKIDHSKPQKATYAREPYHIHYLASSASEYPDDEASAGRLTYLVISPDKTLYRVTCFEFLTTLRTRFLARFPPEKHDFSNFLPYGCAEFEGELRKLMAEYSQRALDVENNGGDSINSVQREIEDVRGIMSRNIEGLLERGERIDLLVDKTDRLGGSAREFRLRSRGLKRKMWWKNVKLMGLLGFVVVLILLTIVTSVKGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5L0</accession>
    <name>G0S5L0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar complex-associated protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0024630</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="12 13 14" key="2">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e56910" last="e56910">
            <title>Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation during pre-60S biogenesis.</title>
            <authorList>
                <person name="Lau B."/>
                <person name="Huang Z."/>
                <person name="Kellner N."/>
                <person name="Niu S."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
                <person name="Cheng J."/>
            </authorList>
            <dbReference type="PubMed" id="37129998"/>
            <dbReference type="DOI" id="10.15252/embr.202356910"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692925.1">
        <property type="nucleotide sequence ID" value="XM_006692862.1"/>
    </dbReference>
    <dbReference type="PDB" id="8I9V">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="CT=1-688"/>
    </dbReference>
    <dbReference type="PDB" id="8I9W">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="CT=1-688"/>
    </dbReference>
    <dbReference type="PDB" id="8I9X">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="CT=1-688"/>
    </dbReference>
    <dbReference type="PDB" id="8I9Y">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="CT=1-688"/>
    </dbReference>
    <dbReference type="PDB" id="8I9Z">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="CT=1-688"/>
    </dbReference>
    <dbReference type="PDB" id="8IA0">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="CT=1-688"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5L0"/>
    <dbReference type="EMDB" id="EMD-35285"/>
    <dbReference type="EMDB" id="EMD-35286"/>
    <dbReference type="EMDB" id="EMD-35287"/>
    <dbReference type="EMDB" id="EMD-35288"/>
    <dbReference type="EMDB" id="EMD-35289"/>
    <dbReference type="EMDB" id="EMD-35290"/>
    <dbReference type="SMR" id="G0S5L0"/>
    <dbReference type="STRING" id="759272.G0S5L0"/>
    <dbReference type="GeneID" id="18256501"/>
    <dbReference type="KEGG" id="cthr:CTHT_0024630"/>
    <dbReference type="eggNOG" id="KOG2153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012441_3_0_1"/>
    <dbReference type="OMA" id="HYCPQVR"/>
    <dbReference type="OrthoDB" id="10263597at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011501">
        <property type="entry name" value="Noc3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016903">
        <property type="entry name" value="Nucleolar_cplx-assoc_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428:SF5">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07540">
        <property type="entry name" value="NOC3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028977">
        <property type="entry name" value="Nucleolar_complex_p3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="12 13 14" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nucleolar complex-associated protein 3 N-terminal" evidence="9">
        <location>
            <begin position="126"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="CCAAT-binding factor" evidence="8">
        <location>
            <begin position="482"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="38"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="536"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="363"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="541"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR028977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS20629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="8I9V"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="8I9W"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="8I9X"/>
        </source>
    </evidence>
    <sequence length="688" mass="77835" checksum="75093ABEEB8DF50E" modified="2011-10-19" version="1">MATRPLKRRKVTPPRDDGQDAAEREAKIQKAFLKNAASWDLEEAWESRPRKGKKKDKKKDEERPGRLPIRTEQGTWQVQDDVESIPSDAEWLDSDGELAVEQQLEPVAPAPAPEPPKISEKEQIRQAQEELAKIATQLNENPEEYPGHFKALARIGETPILAIQKLCIVTQMAVYKDVIPGYRIRPLGEDAVNEKVSKEVKRLRTYEQALVAGYHGYLKTLATYAASSIPEDRKGEPISSIAFTCACELVNAVPHFNFRGDLLRILVKKLSTRKIDRDFVKCREALEKLFQDDEEGNASQEAVSLLSKMMKAREYRVDESVLNLFLHLRLLSEFVGKGSRDTVIRPGDDRPIGKKPKKKWEFRTKKQRKLLKAEKEAQKVMEQADATVSHEERERIQSEILKMVFATYFRILKARVPHLMGAVLEGLAKYAHLINQDFFGDLLEALKDLIRDTDRLEEEDGPDSSQDDDQGVSVVRDTSRESLLCTVTAFALLEGQDAHNARSDLHLDLSFFITNLYRSLLSLSLNPDLELGAQSLHLSDPNDTSSGSTENSRRNNKINLQTTTVLLLRCLTSVLLPPWNIRSVPPIRLAAFCKQLMTLALQVPEKSSQAILGLLQDVVHTHGRKVAALWNTEERKGDGTYKPLSETVEGSNPFTTTIWEGELLRKHYCPKVREGLKAMEKELRSIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5Q4</accession>
    <name>G0S5Q4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Oligopeptide transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0025090</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692969.1">
        <property type="nucleotide sequence ID" value="XM_006692906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5Q4"/>
    <dbReference type="GeneID" id="18256547"/>
    <dbReference type="KEGG" id="cthr:CTHT_0025090"/>
    <dbReference type="eggNOG" id="KOG2262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004965_1_1_1"/>
    <dbReference type="OMA" id="LTWWAFL"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="494"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="553"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="580"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="624"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="664"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="707"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="730"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="759"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="809"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="40"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="111"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="122"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS20673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="875" mass="98288" checksum="9E7FE1446C6599D5" modified="2011-10-19" version="1">MAHPSGDVPTPDPHDGDLTSSRPNPLAVLRSPLSQLRDRLSHLVVPDGGTNESDSEVELLQDPNLPAEHYLRHQPLPRLPLSNNKPIASPDDEDEDEYKDVGEDIPLHHLESQQSHLMNGQEGEEDEEEDEELEDSPYPEVRASVPPRDDPSLPCNTLRAWTIGMSLIFVGASTNTLFSLRAPSISLGSLLAQVISWPLGHGWARWMPEKEISVPVLRLGWFLGRTGSRGERSMFKWETIQLNPGPFNIKEHAIIVVMAGVSFSVAYATDIILAQKVFYKQDFGILWQLLLVISTQSLGYGIAGMMRKFLVYPASMIWPGNLVAVTLMTAMHEQADVRDPTIIGGTIPRYRWFALVTLASFLYYFIPGFLAQFLSSFAFVTWLFPDSPVVNQLFGYTTGLSLIPITFDWTQITGFVGSPLIPPWHAIANTMIGVIIFFVFLASIIHYSGGWYSVYLPMSDSNTYDNTGKLYNVSRILSADYTLDVEAYNNYSPLFLSTTFALSYGLSFAAISSLIVYTYLHHGKTIWRQWKSSTTEKPDIHMKLMRRYKEAPTWWYLSLFVVMLALGFLTVLAWPTNMTWWAFLLAVFISFAFSLPIGIIQAVTNNQIGLNVLTEFVYGYIQPGRPLALMIFKTFGYITMSQALTFVSDLKFGHYMKIPPRTMFMAQVVATTVSCFIQVLVLNYALNNIPNVCEPTQPEHFTCPGGRVFFSASVIWGLIGPARIFSPGQIYSSLFLFFAVGAITPVIIYLLARRRPTSPIRYLMAPLIFGGAGAIPPATPLNYLSWGMVGFIFQYLIKKRYFGWWSRLNFLTSSGLDLGLALSTLVIFFAFTIHDIEPPRWWGNEVVKGTLDYKGEAVQVVLPEGRTFGPNSWRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6A6</accession>
    <name>G0S6A6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0026070</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693066.1">
        <property type="nucleotide sequence ID" value="XM_006693003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6A6"/>
    <dbReference type="STRING" id="759272.G0S6A6"/>
    <dbReference type="GeneID" id="18256645"/>
    <dbReference type="KEGG" id="cthr:CTHT_0026070"/>
    <dbReference type="eggNOG" id="KOG4293">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007077_0_0_1"/>
    <dbReference type="OMA" id="IFQVLWG"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF3">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="9">
        <location>
            <begin position="30"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="276"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="411"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="511"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="229"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="446"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="515"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="565"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="618"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="668"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="721"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="769"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="794"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="848"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="887"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="919"/>
            <end position="930"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS20770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="930" mass="100809" checksum="625BB92472AC4C4D" modified="2011-10-19" version="1">MASADSLSPPGSSTYSSDILHVGDGTWDNERNTFLLPNLMGVNFEMMRYNGMGNRFKDWPQYHRIILGHGILAAITFLFLVPISVLIARFYTARPGMALVYHSYLQIFAVGLSTVVFILGFVAVGPPRNLSNPHHGIGVALYIMLLVQAFGGPLIKKLAGRRSFRLHIHRWLGRATALLGIVQVPLGLTLYGSPKVLFILYAVWMGLLLILYFILDFVDPGCRGLAREGTSTVAGPTSSRITGSRVESDAKSGGRMKRLGGLALSAGAMAMMRGRNKERDVEKALSRSPTPSGRTREPTVISSRPDSYYYNEKPSERRRPSESGGGKGGLMGKLLAAGAAGAILSKFMGGKDRRYRDDYSAVTTDVPSRSRRYGARSEVTATEVTGYTGYTGYTGYSGYTTTDVTDDTRRYDSHLGRRSSVTASTRPPVTRGRRATTPPPRRSYTEGTSTRLESTIQSDYSSYYSPPPRRAPPPERRKSISAAGGSVSGPSGGGAGKGFLASIGLGFLAKLGMGGKDKDQRDERERERLRDDEEKRREEEEERRTSRRMSRYNSDDDYPSPSRRDSHHHPSRLSRRRSAPSTILAASDDVPTIEPRGRAPYDPAPPSNHPARTNTIAPAPPPIPPAGTMPGSSQPFRHDVTDPISMPPMPPDPHGILHRSSDPTISGDSRERERERHHSPSDHHRRRSTRDGAESSTPTDRPPVQGTGTPPTNPPVSVRVQVRDDPERNITLRRLTEEEARREQEQRNRRRGTSAPGAGAGGAGRRDSMSSVSDGETPSSRHYRRDSSSANTVRKVEGVTEAVAEDRLGDLELPNPGYARKAGGSGGNKDSAYYSGGAQGGPSQVPLTTAGPPGAMPAAAATVSSLTTGNSMAPPGSAAHNLVSPGGSYTTFTSQPMTDATAAADRRRRRRLERREGSRAGTTTTTTDYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6K4</accession>
    <name>G0S6K4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0026530</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693111.1">
        <property type="nucleotide sequence ID" value="XM_006693048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6K4"/>
    <dbReference type="GeneID" id="18256691"/>
    <dbReference type="KEGG" id="cthr:CTHT_0026530"/>
    <dbReference type="HOGENOM" id="CLU_2654281_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="76" mass="8465" checksum="C71F10FDF534DA79" modified="2011-10-19" version="1">MQSHQRVHSAHRTQQAGSRSEEGSKREREALAPGWLEAGALHSSSLNPAVESVTGQQQQQQQQQQQQQQPRPDNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6M8</accession>
    <name>G0S6M8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0026770</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693135.1">
        <property type="nucleotide sequence ID" value="XM_006693072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6M8"/>
    <dbReference type="STRING" id="759272.G0S6M8"/>
    <dbReference type="GeneID" id="18256715"/>
    <dbReference type="KEGG" id="cthr:CTHT_0026770"/>
    <dbReference type="eggNOG" id="KOG3872">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017542_0_0_1"/>
    <dbReference type="OMA" id="TWHFKCV"/>
    <dbReference type="OrthoDB" id="687730at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000030">
        <property type="entry name" value="FHA domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067:SF7">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE DMA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FHA" evidence="7">
        <location>
            <begin position="244"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="53"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="430"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="479"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="69"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="435"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="479"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="506"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS20839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="571" mass="61001" checksum="24A835D1CCF0B035" modified="2011-10-19" version="1">MFTHSTTSPTNPGPSNAAVSSVSASPVSTTPTRTSRLRGLSLLRDYAQSHLLSRDGHGSHHAHAHTNGHTHSSASTSAHSTSQPTVLSGTSLSTSAAASTSNNSHTHPSSTRVRLSQFVPALAHPLGQSPSSDPTRHNSCTSPENIRATDSSALPVPSIPPSLTPGGSSDTSFPPTSYDSRPQAETMSGTTSGTTSSSNSTPGPSNFDHLPSIRFSAFIDPRSPRPSLKFNPISRTLPTGKEVIRVGRYSEKENYPPVAPNQPSAAPVGFKSKVVSRRHCEFWFENGKWYIKDVKSSSGTFLNHIRLSPPGTESKPFPVNDGDIVQLGIDFKGGEEAIFRCVKMRLELNRGWQNKLNTFNMETHKRLRNLTGSGYSQDCAICLNSIACIKTLLSGPQYPIFICPNCRAAADLEAEVEDPEDWEKVEAEEFGKNALPSNGNSENNTPAASNQQPQQRQQPVSPEVNMTDALPVQQNVQTNGHASENSSTSMPIPINSCSGTRRTPSPGGGDGGGRLGTANGNHEGPITPRNDAGPWVFDGHGERNRPNSIAAAVLAAAARNPRLFSRENQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6Z2</accession>
    <name>G0S6Z2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0035560</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693986.1">
        <property type="nucleotide sequence ID" value="XM_006693923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6Z2"/>
    <dbReference type="GeneID" id="18257594"/>
    <dbReference type="KEGG" id="cthr:CTHT_0035560"/>
    <dbReference type="HOGENOM" id="CLU_2830994_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="66" mass="7871" checksum="D0FD501226F54447" modified="2011-10-19" version="1">MDAPDLIRKKGAPSWDKEKKREKEEEEEEEEQEEDDAAGNSRTWTQQGSRIIDLRRSRDRGERRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0S773</accession>
    <name>G0S773_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cellulase</fullName>
            <ecNumber evidence="3">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0027670</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693224.1">
        <property type="nucleotide sequence ID" value="XM_006693161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S773"/>
    <dbReference type="STRING" id="759272.G0S773"/>
    <dbReference type="GeneID" id="18256805"/>
    <dbReference type="KEGG" id="cthr:CTHT_0027670"/>
    <dbReference type="HOGENOM" id="CLU_2320116_0_0_1"/>
    <dbReference type="OrthoDB" id="5823761at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142:SF1">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="7">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS20928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="99" mass="10791" checksum="A3CF1A186DD652B7" modified="2011-10-19" version="1">MNEPHDIRNSLLLANLQAAIDTIRATHASNLILAPGNHWFGGHSWTKGGYEANNEWIRKLVDSLNNLAIDVHKCLDEDFSGSRPLCCQAPVSNLAGVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7B5</accession>
    <name>G0S7B5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Very-long-chain 3-oxoacyl-CoA reductase</fullName>
            <ecNumber evidence="12">1.1.1.330</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">3-ketoacyl-CoA reductase</fullName>
            <shortName evidence="12">3-ketoreductase</shortName>
            <shortName evidence="12">KAR</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Microsomal beta-keto-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0036260</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very-long-chain 3-oxoacyl-CoA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="EC" id="1.1.1.330"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Endoplasmic reticulum membrane</location>
            <topology evidence="12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.330" evidence="12"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694055.1">
        <property type="nucleotide sequence ID" value="XM_006693992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7B5"/>
    <dbReference type="STRING" id="759272.G0S7B5"/>
    <dbReference type="GeneID" id="18257664"/>
    <dbReference type="KEGG" id="cthr:CTHT_0036260"/>
    <dbReference type="eggNOG" id="KOG1014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_38_0_1"/>
    <dbReference type="OMA" id="LVAPGMM"/>
    <dbReference type="OrthoDB" id="5545019at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045703">
        <property type="term" value="F:ketoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141040">
        <property type="term" value="F:very-long-chain 3-oxoacyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05356">
        <property type="entry name" value="17beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000317">
        <property type="entry name" value="Very-long-chain 3-oxoacyl-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03107">
        <property type="entry name" value="3_ketoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027533">
        <property type="entry name" value="3_ketoreductase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086:SF2">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086">
        <property type="entry name" value="VERY-LONG-CHAIN 3-OXOOACYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0521">NADP</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS21759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="340" mass="37878" checksum="6C313ED1F75880A7" modified="2011-10-19" version="1">MEVVQELAQKTLQFWNTVPQGAQWALAGVGALYVVRNVLSFVQLILSCFILSGTNLRKYGKKGTWAIVTGASDGLGKEFAQQLAAKGFNLVLVSRTQSKLDALARELTLRWAGLQVKTLSMDYTQDNDADYERLAKLIDGLDVGILINNVGQSHSIPVPFLETARDEMQNIITVNCLGTLKTTKVVAPFLVKRRNGLILTLGSFAGVMPTPYLATYSGSKAFLQHWSASLASELQPYGVDVQFIVAYLITTAMSKVRRTSLLIPNPKQFVRSALGKIGLDSIEMFPNTYTPWWSHSIFKWIVATTVGTTSRFTIWYNRKMHIDIRNRALRKAAREAKKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7E7</accession>
    <name>G0S7E7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0036590</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694087.1">
        <property type="nucleotide sequence ID" value="XM_006694024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7E7"/>
    <dbReference type="GeneID" id="18257697"/>
    <dbReference type="KEGG" id="cthr:CTHT_0036590"/>
    <dbReference type="eggNOG" id="ENOG502SIJF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014597_1_1_1"/>
    <dbReference type="OMA" id="TIWRAYD"/>
    <dbReference type="OrthoDB" id="406634at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF11">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="175"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="207"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS21791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="612" mass="68079" checksum="4A5AD65E23673729" modified="2011-10-19" version="1">MGVYPRAGLNPEISLRGGMRGHGQHERQIRTQRSCRIAEEQSLSRFLTAIEGDERAVDFVRWAFRRPAAGPFRPTQWGQTPLSRSNPQNLQFVPLVPKAQNDHGHKEQAKVKKRLPEVQGKEGICRNCLQKGFVCPGYQQRLQWSTKHEVSTTIKASGPANFTQLVDAASKSIISRSAKPDAPSHNAAQAKASPAPSQQLRPPSVASPMTTAESPSSSSSTLSPPPQPEDQADSVDNSDALVPIVHTPEEQYLEVNVAAEPPLVDIPSFLINHWFNAVCSSWSALDSQNNPYRVLTNQLWRHSSAVYFALQSISAASLVERLPAVMKETAQWAPRRAHEVIQNELVAYSSGLRSEFPSDLFLALFCMSSSMCWMEARQLGQGYVREARRLLRLVNPERLSQADLALYNFFSGCLIYEEMLRSVVSEDETDIEHMLSWPEPALPSGPRLPSASHYWTGVPIDVLRLFGKAMALVRRSRNRWRMNDGTSYQVLQGAMKDIEEAGKVEASLMALIIPQLLVSSNDPQATAQAQNLHYTTEAYRLSSLLQLYITFPDLRDCRLSTTCKESSRPTGPEFLTSLALSITDVLKKVPARSLGCIQPLDFTAFSDDNLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7P1</accession>
    <name>G0S7P1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0037020</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694128.1">
        <property type="nucleotide sequence ID" value="XM_006694065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7P1"/>
    <dbReference type="STRING" id="759272.G0S7P1"/>
    <dbReference type="GeneID" id="18257740"/>
    <dbReference type="KEGG" id="cthr:CTHT_0037020"/>
    <dbReference type="eggNOG" id="KOG0907">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_14_0_1"/>
    <dbReference type="OMA" id="HIHYVTD"/>
    <dbReference type="OrthoDB" id="10263751at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="site" description="Deprotonates C-terminal active site Cys" evidence="4">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="4">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="4">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="5">
        <location>
            <begin position="31"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS21832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="109" mass="12207" checksum="5933F83DAE97D42B" modified="2011-10-19" version="1">MTVHAISSLPEFKETISKYPVVIVDAFAEWCGPCKAIAPALARWSEDPAYKDKIYFVKFDVDAVPDLAQELGIRSMPTFIIFKDGEKVDEMVGAQPQALLGLLNRYKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7S7</accession>
    <name>G0S7S7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor CWC2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Pre-mRNA-splicing factor cwc2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CTHT_0028670</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="22 23 24" key="2">
        <citation type="journal article" date="2025" name="Cell Res." volume="35" first="296" last="308">
            <title>Structural insights into spliceosome fidelity: DHX35-GPATCH1- mediated rejection of aberrant splicing substrates.</title>
            <authorList>
                <person name="Li Y."/>
                <person name="Fischer P."/>
                <person name="Wang M."/>
                <person name="Zhou Q."/>
                <person name="Song A."/>
                <person name="Yuan R."/>
                <person name="Meng W."/>
                <person name="Chen F.X."/>
                <person name="Luhrmann R."/>
                <person name="Lau B."/>
                <person name="Hurt E."/>
                <person name="Cheng J."/>
            </authorList>
            <dbReference type="PubMed" id="40016598"/>
            <dbReference type="DOI" id="10.1038/s41422-025-01084-w"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.80 ANGSTROMS)</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the first step of pre-mRNA splicing. Required for cell growth and cell cycle control. Plays a role in the levels of the U1, U4, U5 and U6 snRNAs and the maintenance of the U4/U6 snRNA complex. May provide the link between the 'nineteen complex' NTC spliceosome protein complex and the spliceosome through the U6 snRNA. Associates predominantly with U6 snRNAs in assembled active spliceosomes. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM CWC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693323.1">
        <property type="nucleotide sequence ID" value="XM_006693260.1"/>
    </dbReference>
    <dbReference type="PDB" id="9L5R">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="0=1-408"/>
    </dbReference>
    <dbReference type="PDB" id="9L5S">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="0=1-408"/>
    </dbReference>
    <dbReference type="PDB" id="9L5T">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.50 A"/>
        <property type="chains" value="0=1-408"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7S7"/>
    <dbReference type="EMDB" id="EMD-62841"/>
    <dbReference type="EMDB" id="EMD-62842"/>
    <dbReference type="EMDB" id="EMD-62843"/>
    <dbReference type="SMR" id="G0S7S7"/>
    <dbReference type="STRING" id="759272.G0S7S7"/>
    <dbReference type="GeneID" id="18256905"/>
    <dbReference type="KEGG" id="cthr:CTHT_0028670"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043308_1_0_1"/>
    <dbReference type="OMA" id="CNIAKDS"/>
    <dbReference type="OrthoDB" id="10251848at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12360">
        <property type="entry name" value="RRM_cwf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000249">
        <property type="entry name" value="Pre-mRNA-splicing factor CWC2, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034181">
        <property type="entry name" value="Cwc2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032297">
        <property type="entry name" value="Torus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16131">
        <property type="entry name" value="Torus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="22 23 24" id="KW-0002">3D-structure</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="19">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="18">
        <location>
            <begin position="177"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="16">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="382"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGS21027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="22">
        <source>
            <dbReference type="PDB" id="9L5R"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="23">
        <source>
            <dbReference type="PDB" id="9L5S"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="24">
        <source>
            <dbReference type="PDB" id="9L5T"/>
        </source>
    </evidence>
    <sequence length="408" mass="45818" checksum="DC7ED97AAE1161FB" modified="2011-10-19" version="1">MAELETNPDVAVAVAEDSNEQKQENQLVAVNNEVAAPIEKKVKKIIRKKRRPARPQIDPALVKSERPPQTGTVFNIWYNKWSGGDREDKYLSQTHAKGRCNIARDSGYTRADSRPGSYFCLYFARGICPKGQDCDYLHRLPTIHDIFNPNVDCFGRDKFADYRDDMGGVGSFNRQNRTIYVGRIHVTDDIEEIVARHFAEWGQIERIRVLNNRGVAFITYTNEANAQFAKEAMAHQSLDHNEILNVRWATADPNPLAQKREQRRIEEQAAEAIRRALPAEFVAEIEGKDPEARKRRKLESSYGLEGYEAPDAVHFARGPNAVNPRGREGFELEREQQLMLEAPPETSQPAQIEAPPQAQEKKLAGGILSSRTLAALQGAKVAVATKDSKPEKPSGPLVAYGSDDEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0S894</accession>
    <name>G0S894_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spo7-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0038020</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694224.1">
        <property type="nucleotide sequence ID" value="XM_006694161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S894"/>
    <dbReference type="STRING" id="759272.G0S894"/>
    <dbReference type="GeneID" id="18257840"/>
    <dbReference type="KEGG" id="cthr:CTHT_0038020"/>
    <dbReference type="eggNOG" id="ENOG502QTI4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032659_0_0_1"/>
    <dbReference type="OMA" id="ENWDEYR"/>
    <dbReference type="OrthoDB" id="5599171at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071595">
        <property type="term" value="C:Nem1-Spo7 phosphatase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005605">
        <property type="entry name" value="Spo7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28249">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN SPO7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28249:SF1">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN SPO7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03907">
        <property type="entry name" value="Spo7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
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        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="437"/>
        </location>
    </feature>
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            <begin position="22"/>
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        </location>
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            <begin position="354"/>
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        </location>
    </feature>
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            <begin position="405"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGS21928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="49074" checksum="45D2FA53CC0E64AC" modified="2011-10-19" version="1">MTEAMADVDSIVKGAPVSLPPGDLSSGTASASGSDDERDNNTNLKGKSLLQHRPGDPLSHTPSSPSMIYLNLLILEASLRAQYLELRARRRHHTFFLSLLTAWTAFFGYALFLAPREDGRGVGGSVYWAVETAERMCFLAGIVTALLVWVTGIWERGIRWPRRWFAVSNRGLRGFNCKLVLLRQPWWKEALSTIGWFLTYGLFSDNGSSYRWVDPALVREVDREMNLDKDTHPAVNVGHWDAEKGGHEEDLAPGGDYVKLLLLAKPFSPTFRENWELYRAEYWEKENERRARLRAKLKERDRQLRKQKYGWLWWLPWRRIPDRPPATTQTSAVAEKAQHPRHAAVAAEHKRARSGSIRRGSMSRGTSGSAAAALLDGEKKGGSSTSSSASENKKRKKLGPGSKGRQRERGERERESRSATPEVPSPLSRESSVADAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8D8</accession>
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        <dbReference type="NCBI Taxonomy" id="759272"/>
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            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21112.1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8D8"/>
    <dbReference type="GeneID" id="18256991"/>
    <dbReference type="KEGG" id="cthr:CTHT_0029530"/>
    <dbReference type="eggNOG" id="ENOG502SQFV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087700_1_0_1"/>
    <dbReference type="OMA" id="PTQFEYP"/>
    <dbReference type="OrthoDB" id="5418203at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="198"/>
        </location>
    </feature>
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        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="198" mass="21416" checksum="1030B4F881A4F0AF" modified="2011-10-19" version="1">MAPKPDELSTNLSKLSINTSLDTSSSKSKKPKKATSPVADSWEDEVDSDDGSSSEKENPPTTATENLDTPKPSGSGTSAPPPTPLSPFATKPSASNFPLTCPSTGPGGFTLPPIDPCSSDSTKPSSGERRRPEKTDAVARRMIASALGMKVPRRTEEQRAYDRALMEAEKKRREAEKEAQRKREKEIEDARKAIWGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8M5</accession>
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        <lineage>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
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                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EGS21985.1"/>
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    <dbReference type="KEGG" id="cthr:CTHT_0038620"/>
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    <dbReference type="OrthoDB" id="4159154at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cell cortex of cell tip"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.700">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF2">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
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        <location>
            <begin position="31"/>
            <end position="412"/>
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    </feature>
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            <end position="297"/>
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        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS21985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="412" mass="44133" checksum="F285714BD96B1F2C" modified="2011-10-19" version="1">MQPHSLILKLIPLLCCGLAVISLSVALAAGVKPNTMEGISIINFNMSRFGQLNITSALDDQVKDVCGLTGTVAKAVDNVVDKAKDVAGKAVDKVQDIGEEAIDAGKNAADTAKDVAKNIGKKLGFGRRDPLLGMVIKGTAKLVGGTGLGKNNEFSEKCTEVLGGLTQFPAALIAKLAGSTARALGIQEYYSVHIGVVCVGSYEPDPFAKNPKINITDCTTKLHRPGSKVFDFLEDLQEKISSGPFNKIKLIDTLRLPEMILKALKLVSSLLTNFSNAFLASVLALALALIVLCLLFVPKLEENPKIQFYCLMASTVLLGTSWLIALVASGIITWMACKIEEKLREYGPKFGIVATRPPGMYVLLWSGVVLESVALAVVTLMVLKETKARKEAKKGRGVEIEMSEKQSWNGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8P9</accession>
    <name>G0S8P9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Eukaryotic membrane protein family-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0039910</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAPT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988042">
        <property type="protein sequence ID" value="EGS20252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006694338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8P9"/>
    <dbReference type="STRING" id="759272.G0S8P9"/>
    <dbReference type="GeneID" id="18258029"/>
    <dbReference type="KEGG" id="cthr:CTHT_0039910"/>
    <dbReference type="eggNOG" id="KOG2490">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003655_0_1_1"/>
    <dbReference type="OMA" id="TCCVLMY"/>
    <dbReference type="OrthoDB" id="5376140at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008010">
        <property type="entry name" value="Tatp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317:SF4">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05346">
        <property type="entry name" value="DUF747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="507"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="803"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="376"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="239"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS20252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="928" mass="102870" checksum="9B599E95F61349EF" modified="2011-10-19" version="1">MDPDPNAGKASPSPSPSSAASPAIAEGFMNPSDARDGESRAKGQHDPARSKDKSSTRPSHAHLPSPVLTPNDPPDPVPEPRAQEPPSSSTKGVPTPEMSGESSEGERSKHDGNTQAAEGKTRPRSNTKSSQTDGVRRLSASKMQELTAPEALPVAPVSNETNPGEHSRRENERGSRSRPVSTPPTNRRRSSVQPPAQPSSRRNSFQPGHRPPPMDLKATENAQANPKPEAPPPEKRPSDPSPPSPIPPTIPLPPMSIPTHLQLELAGQRPSPLYIHHSHTVDIPYESYAVKFERLKNFLLLPWFLERAMGFGVLACLDAWLWTFTVLPIRFCIALGVLGSWWLHAIMAEGKFIVRFVWGGLGRMWKRGRVKKAVEGEGEQVEESTGSSTGIGAGNETKKRIPQTPTQTQGVFRHRRTRSKPSNLTTFHKADLLQGAIILCSSIALMNLDASRMYHFIRAQSAIKLYAIYNLLEVSDRLLSALGQDVLECLLSTETLSRNPHSGRSRVMLPLGMFILALVYNILHSVILFYQVIALNVAVNSYSNALLTLLLSNQFVEIKSTVFKRFEKENTFQLACADIVERFQLWVMLTIIGMRNVVEVGGLSVPGAGSEDGPSSFPLHTSSILPASFTILPSWIWSGEVLSPFFVVIGSEMVVDWIKHAYVNKFNNIKPSFYGRILDILCKDYYTNAFVTPSLTRRLGLPLLPLSCLFIRASIQTYNMFLATHLPTPLPPSTQTSLSVESATPSPAMIAALDRLDNIIRNALGRAVYGAPPYLDPSSPESFASETSLLSRIFTLRLTSDDAIAALTFLTVFLLLFLILLLCKLLLGMLLLRYSRNIYARMKLAEHNISLGKQERESYDAHGKRTGGYGTVEVGDERRRWLFADDGEGLRKVREKERRAEEKREKERERGVDLAGIRRYEMVARRIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8R8</accession>
    <name>G0S8R8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0040100</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988042">
        <property type="protein sequence ID" value="EGS20271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694420.1">
        <property type="nucleotide sequence ID" value="XM_006694357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8R8"/>
    <dbReference type="STRING" id="759272.G0S8R8"/>
    <dbReference type="GeneID" id="18258048"/>
    <dbReference type="KEGG" id="cthr:CTHT_0040100"/>
    <dbReference type="eggNOG" id="KOG1014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1906510_0_0_1"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS20271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="133" mass="14022" checksum="4E135CDE3ED0CB47" modified="2011-10-19" version="1">MARLTALLIPPLVRKKPSAEPTKTSNLSLIISMSSGAYHGPPWLVMYGATKDSNRSFGIGLGLKLAQDPSTAYIDSLVAVPGEVLSRGNCRGVPSHTPRRDEYGRNVVRKAGLAPPAAGARYTLIGGIASNTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G0S927</accession>
    <name>G0S927_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoglycerate mutase family-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0044310</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694823.1">
        <property type="nucleotide sequence ID" value="XM_006694760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S927"/>
    <dbReference type="GeneID" id="18258469"/>
    <dbReference type="KEGG" id="cthr:CTHT_0044310"/>
    <dbReference type="eggNOG" id="KOG4754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039184_1_0_1"/>
    <dbReference type="OMA" id="HDKITHL"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF54">
        <property type="entry name" value="PHOSPHATASE SPAC5H10.03-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="272" mass="31615" checksum="D8E2EC427C24A354" modified="2011-10-19" version="1">MTIYIYLVRHAQGQHNVAADHTLRDPDLTALGIEQSTQLAISFPYHDRITHLISSPMRRTLRTCFYGFKNRGKGDDNGTRKPILALPELQELSTMPCDVGSSVAKLDAEFNTSEEKVVDLSELPDGWQLFKLDSNSLFAPNMDRLEKRAWQARRRLREIGQKYERDHPGQDAHIVVVSHGAFIHFLTGDWEGMTKEGQAGTDWRNAEWRVFEFVEGDEDEVRLRETEESWRRRKGDTPRLTETQQRELKTNVEKVLEEDKKEWKKVTVCFQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0S966</accession>
    <name>G0S966_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0044730</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694862.1">
        <property type="nucleotide sequence ID" value="XM_006694799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S966"/>
    <dbReference type="STRING" id="759272.G0S966"/>
    <dbReference type="GeneID" id="18258511"/>
    <dbReference type="KEGG" id="cthr:CTHT_0044730"/>
    <dbReference type="eggNOG" id="KOG3328">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089876_12_1_1"/>
    <dbReference type="OMA" id="KQIMRAM"/>
    <dbReference type="OrthoDB" id="46529at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000033">
        <property type="entry name" value="acyl-coenzyme A thioesterase 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF57">
        <property type="entry name" value="PAAI THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="57"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS19977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="175" mass="18717" checksum="FC46FA37586733B9" modified="2011-10-19" version="1">MASKTPKLPPARFVRSVLKSFMQDSGLEPRLFGPHLRITNAQEGRVDFELDIQPHHTILHGGTIASMVDLGGSLAVASNGLYATGVSTDLNVTYIGSGGKVGDKLRATAVLDKIGKTLAYTTVTFYNDKGEMTARGSHTKYVRAAWNPDLPLWHAPEGAPVAEEEPEGNGEAKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0S992</accession>
    <name>G0S992_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0045000</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="476" last="476">
            <title>High-resolution structures of a thermophilic eukaryotic 80S ribosome reveal atomistic details of translocation.</title>
            <authorList>
                <person name="Kisonaite M."/>
                <person name="Wild K."/>
                <person name="Lapouge K."/>
                <person name="Ruppert T."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="35079002"/>
            <dbReference type="DOI" id="10.1038/s41467-022-27967-9"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.90 ANGSTROMS)</scope>
    </reference>
    <reference evidence="12 13 14" key="3">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e56910" last="e56910">
            <title>Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation during pre-60S biogenesis.</title>
            <authorList>
                <person name="Lau B."/>
                <person name="Huang Z."/>
                <person name="Kellner N."/>
                <person name="Niu S."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
                <person name="Cheng J."/>
            </authorList>
            <dbReference type="PubMed" id="37129998"/>
            <dbReference type="DOI" id="10.15252/embr.202356910"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <reference evidence="16 17 18" key="4">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e57984" last="e57984">
            <title>Structural insights into coordinating 5S RNP rotation with ITS2 pre-RNA processing during ribosome formation.</title>
            <authorList>
                <person name="Thoms M."/>
                <person name="Lau B."/>
                <person name="Cheng J."/>
                <person name="Fromm L."/>
                <person name="Denk T."/>
                <person name="Kellner N."/>
                <person name="Flemming D."/>
                <person name="Fischer P."/>
                <person name="Falquet L."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="37921038"/>
            <dbReference type="DOI" id="10.15252/embr.202357984"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.12 ANGSTROMS)</scope>
    </reference>
    <reference evidence="10 11" key="5">
        <citation type="journal article" date="2023" name="Nat. Struct. Mol. Biol." volume="30" first="670" last="677">
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                <person name="Kisonaite M."/>
                <person name="Wild K."/>
                <person name="Lapouge K."/>
                <person name="Gese G.V."/>
                <person name="Kellner N."/>
                <person name="Hurt E."/>
                <person name="Sinning I."/>
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        <citation type="journal article" date="2024" name="Nat. Commun." volume="15" first="716" last="716">
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                <person name="Kunze R."/>
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    <accession>G0S9Y7</accession>
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                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
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            <dbReference type="PubMed" id="21784248"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor TFIIIC triple barrel" evidence="2">
        <location>
            <begin position="17"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS19559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="889" mass="102592" checksum="A2FF7A5A849DB400" modified="2011-10-19" version="1">MNSIDDVDEWEYEYSTTETETYYLTLDLSVRDFLERRTDEIFHNTRSGYRVWYNPIFNAPEPQATNPDLLDDKDADDGEPPEREDADLDAIGMPPVSSRTPVDPMLEQNSGKDAQAEEQYPGTKAAEEIQILDLHSKEPIVSYRNHIFRGTWCENIGTEMIFAQHDDRSPLPALRRLGQNIDLLAASSVRINFQEATLQPRDKDIISGKFMYGTADNWEDIPERYKRNGGIYVHIGGDKSGLRQPQAHFLEDLIALKRKRGETDEVTIQPLETRHNNLMVEDEEEERRRRKLQQDHARNVRWRAKRQEEREMGLEPTRSDYVPGKNLKGKFPRTRARRAVLISRDTGVISRYVPRLLNPTPPDPEERDRDKHWVNTSPSWIDRQVCRWLGLCGLQHLRWDAPARPDRGDHSMMEAIKMIAAGWSEGYTFVEKVGESDWETAPVKPDLKRIRTSRALGNNNNNNNNNDDDDDDVRILNEVPDYVLLHAPLVHLYSGENFWPSDIAEHIQHLRPYQDGKELDLGKPLHLGNLATLNELNGSVFLTSEDDVEWRPRWLHNRVGIPTPFKDDGDYFPGGDGNRQPEPPEDGSTWWDADRKHPPHRIVPPFRSQNHRNRGQLGWRDKTRLQRRAAANQQRPIVGSGLNNKPDSSGYSKAPAVLILVDKGAGILDAFWFFFYSYNLGQTVLKIRFGNHVGDWEHCMVRFQNGIPRAMFLSEHAGGKAYTWHALEKRAQNDGKPPRPVIYSAVGSHAMYANPGLHPYVLPFKLLRDVTDKGPLWDPTLNHYAYWYDYEVDEEESRNGTIRDTDRTSLVPAASNPDLPTSWFHFEGFWGDDVYPLSDRRQWRIFGEYHYITGPLGPKAKWLDRRKVCQTEKCIIVDSIEAGKKSAWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAD0</accession>
    <name>G0SAD0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0041840</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694587.1">
        <property type="nucleotide sequence ID" value="XM_006694524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAD0"/>
    <dbReference type="GeneID" id="18258222"/>
    <dbReference type="KEGG" id="cthr:CTHT_0041840"/>
    <dbReference type="HOGENOM" id="CLU_1626834_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="163" mass="16421" checksum="8DD38D60F893F680" modified="2011-10-19" version="1">MSLQPLPQSSPSYPILPLWGLDESPLTPRGKGGGSGHSGGSSSAGSSSSSNSDSSSSGGSSYSGSISWKDGNGNSGSSQGSCYSTEKVCDNYWCIPNGATCCNHADGMYCNSCVSSNSFTSSSSSRGGSSFAISGMPAQVAKPQKCPVLAVLTWTALTYALTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAJ4</accession>
    <name>G0SAJ4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0042500</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694651.1">
        <property type="nucleotide sequence ID" value="XM_006694588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAJ4"/>
    <dbReference type="STRING" id="759272.G0SAJ4"/>
    <dbReference type="GeneID" id="18258288"/>
    <dbReference type="KEGG" id="cthr:CTHT_0042500"/>
    <dbReference type="eggNOG" id="KOG3026">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069491_1_0_1"/>
    <dbReference type="OMA" id="CMAVWSQ"/>
    <dbReference type="OrthoDB" id="79171at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd20446">
        <property type="entry name" value="Tudor_SpSPF30-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041297">
        <property type="entry name" value="Crb2_Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46297:SF2">
        <property type="entry name" value="TUDOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46297">
        <property type="entry name" value="ZINC FINGER CCCH-TYPE WITH G PATCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18115">
        <property type="entry name" value="Tudor_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="4">
        <location>
            <begin position="98"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="51"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="214"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="257"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS19766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="302" mass="33035" checksum="85CC0B7BA360A0EF" modified="2011-10-19" version="1">MSAAQLEADRKEYESQLELVITSLKDDPDNAELLGLKNELEQMIKLIDDSLAELKPKHEPKAAPKKAQSPPHEEPKWSRENHPTFRKAASEEKEPETITYQVNDNVMARWVSGDKAFYPARITAVTGSSTAPIYTVKFKNYDTVETLRAKDIRPIAQKRKADGTPVSGGSSAIGGAALTAATTPASATSLTPTSSNNGIVLSAAADLYPHAQAAKAAAENKDDKPQPKFKKLKATKELEKSKSKWQEFTAKGKISKSAMKKESMFRTPEGINGKVGFTGSGQPMRKDPARTRHVYQHSDDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G0SB14</accession>
    <name>G0SB14_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">RecF/RecN/SMC N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0048530</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695216.1">
        <property type="nucleotide sequence ID" value="XM_006695153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SB14"/>
    <dbReference type="STRING" id="759272.G0SB14"/>
    <dbReference type="GeneID" id="18258891"/>
    <dbReference type="KEGG" id="cthr:CTHT_0048530"/>
    <dbReference type="eggNOG" id="KOG0250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009063_0_0_1"/>
    <dbReference type="OMA" id="FMCHRSL"/>
    <dbReference type="OrthoDB" id="10072614at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306:SF6">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="14">
        <location>
            <begin position="136"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="723"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="329"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="756"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="727"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS19394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1176" mass="134498" checksum="0A15334C132BA751" modified="2011-10-19" version="1">MPGVVDSPEAESSRKRARRAAGHDGDDNGYVVEVRNTYGNQRPALRKRMRLSEEGPSRSGFTHQPSEDSSGDSVNARDAVEPPSSPPRTQYDLMRDGHFEHLQYEAQDDQRATQRLRSRTNVLSHNTVAENGILESVTCVNFMCHERLHCELGPLLNFIVGENGSGKSAILTAITLCLGGKASSTNRGGSLKAFVKEGQERAMLAVKIKNRGHDAFKPELYGDSVIVERHFSKSGASGFKVKSATGVTISTKKQEVEELVEYYALQVDNPLNILSQDNARSFLNSANKYQKYKFFIEGVQLQQLDNDYRLIAENLDMMVSKIPDQEEMVNRAREDFEKAKRLRESLEGARRIRAKAKVVRAQLAWIQVENEERELQKQEEKLNRLNEHIAQTDREIEEQAEALARADQQIAQAEELVSEVKQEQDDVKRRSEQARDELNRLRGELEKLHSDERDANENLKRIEEDIQKKEEEIGRERKRLESKNNGQHAAKLKELEEAKVEVANLGQKLKEVNERRPELIKAIDETNKKLEQIDKDVTSKRVQIDKVENSIRNLETSRGSPYDAYERGVAALVKRIDQDNGFRDKPIGPLGAYLRLTEPRWSYILEATLGGSLNAFLVTNNQDQKRLSAMMNELNVRHCPILICNPRPLDLTGKEPDPEYNTILRVLRIDNIMVRDQLIINHAIEQILLVPERVRAEQIMFDGARPRNVRACLALHDTRPNEGIRLTVNTGGPSTSPVQPDMRQKPRIQTDSDAQLNLQREALQRLRAELNALESEQRRLRQASQHATASLHQFERERLDLERKIRNAKALVETLTAELEDLTSGDTGHLNGLEQVLKDLEKQRELVGMQFGTLALQKQEKNREVEDARKKRAACRKEEEEVESKLKKAETKLQKRRDIRQVVLIEKNNLHERLDKLNRDKAELEDVIQETTRKLEAMSAEARTVAAERPAIPPGETHSSLEQKYASLDRHLRKLEKDRGKPEEEIHAEYAKATEAYEKAVQSLESTKLINQRLQQSLTQRLAKWRKFQRYISSQSRANFIYLLSERGFRGKLLLDHKRKALDLVVEPDQTQKQAAARSTKTLSGGEKSFSSICLLLAIWEAMGSPLRCLDEFDVFMDNVNRAISTNMLITAARRSVNRQYIFITPNAIEGRNTLDKDVKIIRLTDPRQRTLINHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0SB91</accession>
    <name>G0SB91_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyltransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0049340</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695293.1">
        <property type="nucleotide sequence ID" value="XM_006695230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SB91"/>
    <dbReference type="STRING" id="759272.G0SB91"/>
    <dbReference type="GeneID" id="18258972"/>
    <dbReference type="KEGG" id="cthr:CTHT_0049340"/>
    <dbReference type="eggNOG" id="KOG4750">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051638_3_1_1"/>
    <dbReference type="OMA" id="FYSGTHP"/>
    <dbReference type="OrthoDB" id="25818at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03357">
        <property type="entry name" value="LbH_MAT_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051159">
        <property type="entry name" value="Hexapeptide_acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416:SF54">
        <property type="entry name" value="ACETYLTRANSFERASE, CYSE_LACA_LPXA_NODL FAMILY (AFU_ORTHOLOGUE AFUA_2G08430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416">
        <property type="entry name" value="SIALIC ACID SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Maltose/galactoside acetyltransferase" evidence="3">
        <location>
            <begin position="12"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS19471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="226" mass="24762" checksum="667F098EFE3B1112" modified="2011-10-19" version="1">MDPNSIDIAENRRRMLAGELYYAWTPDLTADRQRCKAATKAFNERCTSGNASRRELVELWKAILNDTTPLPPPGATPEEDQKLLRDYPWCDGAIKFDYGFGSQVYINSNCTFLDTCTITIGSRVLIGPNVSFFAATHPTDPFVRNGLLGPELGKPITIGDDCWIGGGAIICPGVTIGRGVTVGAGSVVTKDVEDFVVVAGNPARVIKRLDVEAQLKKEREERESNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0SB94</accession>
    <name>G0SB94_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Hydrolase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0049390</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695296.1">
        <property type="nucleotide sequence ID" value="XM_006695233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SB94"/>
    <dbReference type="STRING" id="759272.G0SB94"/>
    <dbReference type="GeneID" id="18258977"/>
    <dbReference type="KEGG" id="cthr:CTHT_0049390"/>
    <dbReference type="eggNOG" id="KOG2230">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005015_2_4_1"/>
    <dbReference type="OMA" id="AWPNLHW"/>
    <dbReference type="OrthoDB" id="408532at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043534">
        <property type="entry name" value="EBDG/EBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041351">
        <property type="entry name" value="Ig_GlcNase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041447">
        <property type="entry name" value="Mannosidase_ig"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43536">
        <property type="entry name" value="MANNOSYLGLYCOPROTEIN ENDO-BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43536:SF1">
        <property type="entry name" value="MANNOSYLGLYCOPROTEIN ENDO-BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18368">
        <property type="entry name" value="Ig_GlcNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17786">
        <property type="entry name" value="Mannosidase_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409454" evidence="6">
        <location>
            <begin position="23"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="10">
        <location>
            <begin position="59"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="7">
        <location>
            <begin position="230"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosidase Ig/CBM-like" evidence="8">
        <location>
            <begin position="689"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="Exo-beta-D-glucosaminidase Ig-fold" evidence="9">
        <location>
            <begin position="786"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS19474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="897" mass="101608" checksum="DF0A159F22E76370" modified="2011-10-19" version="1">MKTARSTALLLLLSQLFLHVDATLVSKAGQVAVIPTWDLQSTAVVGNDLGKLSRDRLDTESWYHAPVSKCTLIGCLIEAKVYNETELFFSDNLRKLDENKFLVPWIYRSEFTLQPTPGQHFFLQTNGISSRADIYLNGKKVANSSEQAGSYVGRRYDITDIVRTENVLAIKVYPTDYYRDLALGWVDWNPWPTDNGTGVWRDVEIKQTGPVVLDPLRVVPYLGAPLTLPVKVSLRARLHNLEDRAITIEAVAQVALESGGTKYTRRQLITIPPKSSLDIFFEEFIENPQIWWPRQWGDQPLYIANLTIQTIDGNISDHASATFGLRSVTRQLNAHNDTIFFVNNRPFQVIGAGYTPNMFLRFDPAKWETELRYALDLGLNTIRLEGKNEHPELYNIADRLGMMLLAGWECCDKWEAWDYNPDLAVSPTPVWTDEDYAIAHESMFHETLMMQAHPSVLGFLIGSDYWPDERATSLYLEAARKADFQLPVIGAASKRGFSMQTGPSGMRMDGPYDWVPPNYWTTPDTLGTAAGFASELSAGVGTPGSLSSLEQFLTADDMDDLWRQPNKSLFHMSRAGSPFDTREIYNAALWARWGAPTSLDDYLMKAQLMDYEATRAQFEAFRAHWGDGRVLAQGSKGPATGMIYWMLNNAWPGLHWSLWDYYMRPGGSYFGAKVAGREEHVAFSYATKDVWAMNRALEVPIGQEKRRIEVSVLGVDGKEMFKGTSVFTTKPNWSGRVESLREVLGKVNDTVFLRLILTDEKGKTLSRNIYWLAPEIDVLDWEQSDWYFTPVTKYADFTALNKLEPADITIDAVVDGDGVFVTVENHAMVPAFFIKFDLVDEHGRDVLPLTWDENYVTLWPKEKLTLRAGVVQGRKWEPVQLKAVGKNTEKTIRLKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBD5</accession>
    <name>G0SBD5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C6 zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0049870</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695337.1">
        <property type="nucleotide sequence ID" value="XM_006695274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBD5"/>
    <dbReference type="STRING" id="759272.G0SBD5"/>
    <dbReference type="GeneID" id="18259025"/>
    <dbReference type="KEGG" id="cthr:CTHT_0049870"/>
    <dbReference type="eggNOG" id="ENOG502SJ6A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_514813_0_0_1"/>
    <dbReference type="OMA" id="MIWRECA"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF7">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="529" mass="58079" checksum="53C29E89B2E343D4" modified="2011-10-19" version="1">MSVIHVGFCDVAKTRYQPHNGSSNAPRGEELAMDMLELSEHPTHGPQPSGQPTRIASASHRAMLDPIPASSHVVVEETPASTESSTSTTPAPTPPTSATPASLPRPQGYTTFGRRSHKKSRTGCAVCKARKIKTSILHPTEDDPLPTLELELLHNFTTRTYTTLTADSSLWTFWRDDMVQLGFTCDYIMRAVLAVSALHLAYHRPDKRDWYTAQAILLHQRASRSAMKVMERAEGLDKDETACLFLFSMLTVFFALATPRSPTPSGTFFIGDSGIPDWAFLLSGAKSIMDVLGWERRHETVAAPFLYYGARRWEAHCAKLKAVKEKLGAGAASGSGLESGSCGEGSASGSASNPGLESNIASGPGSITSSVASSLAPGSAAEGISSRLLPLTSLREKISATIPASETDLLKTYLTALDLLEPSLLIITHEHSLSLHDSPHFRHDTKDVLDAMVWLWLVSDSLVPLLREPTKHQEAVVIFAHFCVLLKHYDSHWWLQGWADHLMGRAMEILDEEHRAWIKWPVMEMRWKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBG3</accession>
    <name>G0SBG3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Putative fatty acid protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CTHT_0050170</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 16">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695365.1">
        <property type="nucleotide sequence ID" value="XM_006695302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBG3"/>
    <dbReference type="STRING" id="759272.G0SBG3"/>
    <dbReference type="GeneID" id="18259055"/>
    <dbReference type="KEGG" id="cthr:CTHT_0050170"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_5_4_1"/>
    <dbReference type="OMA" id="VAPGFNI"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000040">
        <property type="entry name" value="Bifunctional cytochrome P450/NADPH--P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF108">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="6 16 17" id="KW-0349">Heme</keyword>
    <keyword evidence="14 16 17" id="KW-0408">Iron</keyword>
    <keyword evidence="9 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15 17" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="13 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="binding site" description="axial binding residue" evidence="16">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGS19543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="464" mass="52611" checksum="71005C9341A4919D" modified="2011-10-19" version="1">MSTPIPRPPGVPLLGNVFDVDSNNTWWSLKKLAEKYGEIFEIKVLGHHIVFVASAALAQELCDEKRFHKAVTGPIVEIRYSVNSSLFTAYHHEECWGIAHRIIAPKLSQESVAELFDHFVTTTEELVAKWTSVDPDTPIQPLRDLNRLSFEATVLSLYGMKVNNINGPEHPVIQAMEDATSEAMKRPTRPKLLNWLVYGRKFKKATKVMRDFAAEVVKHRREHPCDRHDLLWALMNGKDPETGKGLTDNEIIDEIVTMPIGSSTAPCAIAACIYYLIHNPAVVAKAREEIDTVLSDEPFQHDHLPQLHYIMGVVRETLRLSCAAPGFNIEPIPKEGDKSPVLLAGGKYSVPHNQTMIIVLAGVNRDPAVFEDPEAFKPERMMCESFAAMPEGVKKFFGNGMRECIGKNWAWDWLMVVTTLLIRSFDFEAADKNYEFMQDGWFNIRPIDFYIRVKPRQKEVDLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBI4</accession>
    <name>G0SBI4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0053690</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695705.1">
        <property type="nucleotide sequence ID" value="XM_006695642.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0SBI4"/>
    <dbReference type="GeneID" id="18259407"/>
    <dbReference type="KEGG" id="cthr:CTHT_0053690"/>
    <dbReference type="eggNOG" id="KOG3519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001112_0_0_1"/>
    <dbReference type="OMA" id="DQVGWIW"/>
    <dbReference type="OrthoDB" id="10256089at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031991">
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    <sequence length="2093" mass="227131" checksum="C736F3B55C194FE3" modified="2011-10-19" version="1">MDHGSLGEDAVRRSGPIVALNHHSHARSHSRSHSHSHTHHFRSRSSSRDDDTPPALGCSPDSIDDPKLQKIPIDAYAAANLHGFQANVRATDASNDPDDDPVDPADFYRSYREGAQPGHVAAPSLTDPMTADLPASPQLSASAANTNTTSPRRPTSSRSNGTGAPLKGPQATTALPQRGIPQPSQRSVSNPAESRIPTPSASATSTRPPLTVSHVPSVKDLKKRFDQSAPSSQSTDPVRKSTPRSRDPSLNGRLTSAGTGATSHGAPTTSSGTRDTPRDPTKTSHTRPRYLAGDPSHNISQQSFASRIARPRAGASKPPNDPGSRTLLFGEILPEQSGSATPGFGIESVTRPRRTSDSSIQNPTRYQMRSRSDPDVEPPSPSDWYRTVDSSQQHGFDHAATSLSKNHSRARSDLAGSKLPLPPIRPDIAVSKRDTDSPVSPVSSTSQTSTASRLPRLAKRMNTSSSHASPVSSRSSSPSAFRYSTGAGRSSRQPAQSTASRSKTPTTSSSSQVKTPSQTPTSSARKAPPPSTTTSSASRLNAYVAVPPPKLSPPLRSSRPRQSVASATTAASRMRAVERTPAPKQEEPTPRRRKISVGAIDFAQRRETIKLAYSKSLRETQALEARKAAAEKRKKELETVAKTKVEAEAAVVAALANSTATALAAPVLPRKTSSRRPSTTDPLAGSILTSARPGSEPREPEAAEAGQLPAESASGPAETAAESLPRIELPVSRELTPTEDSGLPEASVVLQEPHNEPLNYRPSSLRLEIPGAFPDAELVPSSHDDMPISAVSDTSAITEFDTEVQTEPPRQESGPVAGASLDEIPPALSQSAAEPKVTGQSLHEQQPHSSIQHDQKSASYRPSPENEPQEDDCVSIKISLDTSAIPDAQPRPSSQPAPARPSAYMPYPADEDDDEYVPRPYIPPADSYKTTVTILGPDHDFKPLHKDQPRETTPLAGLRQADELSAAAAASEPGSRGASRLDESRFEKGSPDLEGLERIEDFYIGPRLRDNVAALRDSTFTSSGSGTNTPLDVHHSSSSSQYPEPSGINTSLGLTVPSLLAPGNRQSHHSAWTDFSIGSEEPDGGRPFSAAASHDDYLTSEGGVIRVRPSVGDLSTCASSFGELTQSPEISSSLDRSRAPSPPMLPELPPSRQLSLEPESADILTARSEPGSTRTSSVSRPPIPERSSSVRTCDQESRTLYLSESRPHSYAHSHDGLQPAGSTNTMSPPASVSRLQLDSAAGSRDSLGESTLAEQQSAPLTEEEQAEQKRLRQRQLVIRELIDTEETFVRDMTVVEEIYKGTAEACPNLDSKTIKLIFRNTDEIIAFHTALLAEFKEGASTVYTPPKARRSPQLAPNAPDSDSSAAAPTASSSKIQHDDEKDRLTSLGPIFTRNIDQLKAVHETYLRTSDAAAKRLLQIQEDKTVMVWLNECNVVAKELTTAWNLDSLLIKPMQRITKYPDIITHLLKYTPDNHPDREPLIQARTAVIDAIDEINKSKKNFELVGQIVSNKKRKESSDVRLGLARAFGKRVDKLQGTGSKTAEDEEYQRLQQQFSDDFLRLQVVLRDVEFYTRSVSTYVHEFLQYLSSIELVMRLQPSRDYAHIESKWVQFNVSMRDIEKVALEKHLADVRKHVIEPFEQVIRCYTNPSLAMKKRAKRRLDYERYMQLKANGKKIDKQLAELVEQYEALNDTLKKELPKLSALTARVGNICLGKFICIQASWFAMWKEKVKMPLQELGDHVPEPAEIVSAFQREFSIQEERAMSLGILNPALKTRTSQSTTDEASSVLSRTRSRPSDLGSTRTRGLSINSDNNAPTLPTPDFGKRNSGQFTLSPASSGLPSPANYYRDFYPGINNTSSPQLRGGSGSPVTSSDPHATTTITTTTTTTTTTTNNNNNNNNNNNNNNGSAASSSASFSSRQPQQRPSTGRSLDSTGMPRQSSDSTAFYSAYMHQTPRSRRGSNSTFNSNIVAATETRRHSGLFQSALPPPDTPGATSAAEEFFFRSGVSSRASSPAGERGGSQHKVLWLAASLFEFNIETTKYEAGYPYLTYQAGEIFDVIGEKGELWLAKNQDDPSQTIGWIWSKHFAKLADDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBM3</accession>
    <name>G0SBM3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcription factor regA-like protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="9" type="ORF">CTHT_0054090</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EGS18799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_006695681.1"/>
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    <dbReference type="GeneID" id="18259447"/>
    <dbReference type="KEGG" id="cthr:CTHT_0054090"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003487_0_1_1"/>
    <dbReference type="OMA" id="ITMMRYR"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="XnlR_reg_dom"/>
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        <property type="entry name" value="Znf_C2H2_sf"/>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
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        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
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        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="922" mass="101699" checksum="A8B3C9667D47D7C0" modified="2011-10-19" version="1">MAGPIGYLINSDPAPPTPTISQVQQVPSVPSSASVAQPAAPSAPLPGHPGLPSVAPLSSLPSFTSAPVANTNAALTTPIVNHSPFRTSEASDTSGLPLVLTLPSPSVPPVSSVPSVSPASSVPSLPPVPSNDPASSPPTRLGSNGHNASTSAGSHAKGKPLYQCADCLRRYSRPEHLQRHIAAHTLGKRFTCDAGFSSRLGQGLGANTFNRCTRCKTRGLRCEVSLSEDALHLHHMPVNRSHVHPEDSVPSSSNASSAYQVTLELKTEESPGSSSSQELAGTVPSLYKEESQIPTPAASLDQTSSDFGPYTAAYLGPAHDEHTKPGFPDFIRDILYRSSYGDASTKLVDVQASAVLDFYDDTNFADFNDFNFDPLSHWNIDASRTAADQADGADNPPSITAMRAALCKLWTESPWRWIPEKTDSRYTEQSNLPLSSHDAQGVQLEANPMPVDRVTKDVLQGSSRDKILAIVLGTLRDNATINRVASSFPSTDAMDSWINVFLAAHLCQTSSWIHYASLYLNSQYPEWLAIAAAAGALLTPVLPLRRFGLALQEAVRVAIPERASAIFEENNRSIADLGKVQALVMIWDVGLYSGNRRKMEIAECHFPIAITMMRYRGKFARSAYQQITIYPTDEGKILEDKWKAWCQYESWKRLSFHTYLRDAQISMTQFNNMNMSYAELTLPLPCSTQLWFARSAEEFKACYLQAGFSDNSKRLPSLGDLFRDISLLSANRRLLDVQFSLSIYLHGFWTLIWEYRQMYSIQRPSCSANPPPPNPLLEARREDLQKALSNFHDLIRGWQEATQEIMLLFHLILMNLYVSILDLQLFTGKEGEEQARIVYPSLQRWAVSPDARRALWHAGQILRHARSFPKGHLKEFSVIAVHHAALSEQVMPWKESRKNRSHRLIGGKNINKIGEEFSSSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBN7</accession>
    <name>G0SBN7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carbohydrate kinase PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0054230</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695758.1">
        <property type="nucleotide sequence ID" value="XM_006695695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBN7"/>
    <dbReference type="STRING" id="759272.G0SBN7"/>
    <dbReference type="GeneID" id="18259461"/>
    <dbReference type="KEGG" id="cthr:CTHT_0054230"/>
    <dbReference type="eggNOG" id="KOG3009">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012201_3_0_1"/>
    <dbReference type="OMA" id="FNCIIAT"/>
    <dbReference type="OrthoDB" id="198885at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004730">
        <property type="term" value="F:pseudouridylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01941">
        <property type="entry name" value="YeiC_kinase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1790.10">
        <property type="entry name" value="Indigoidine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022830">
        <property type="entry name" value="Indigdn_synthA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007342">
        <property type="entry name" value="PsuG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909:SF1">
        <property type="entry name" value="CARBOHYDRATE KINASE PFKB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909">
        <property type="entry name" value="ZGC:136858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04227">
        <property type="entry name" value="Indigoidine_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110581">
        <property type="entry name" value="Indigoidine synthase A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="6">
        <location>
            <begin position="431"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="6">
        <location>
            <begin position="749"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS18813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="818" mass="88227" checksum="FA172634AA97601B" modified="2011-10-19" version="1">MAHLRRLPSIPRQPNYAFLRSHYQSYTSAPFLSRLINIHPEVADAIANNRPVVALESTIYTHGALSEDFPHALDRLVREHGAIPAVCGVYAGVPTVGLQPAEIMRMVSEGAKKASRRDLAYLVGKGDKLHGGTTISGTMVLARLAGIRVFGTGGLGGVHRGGESSMDVSADLTELGRTRVAVVSSGCKGFLDIPRTLEYLETQGVLVATFADEGQERVEFPAFWARESGSPSPAVVRDEKEAAGIILAQEKLGIESGLLFANPIPKQFAIPRKDMEEIIATAVREAEEKGFTGNANTPYILKRIRELSQGKSVPANKALVEANVGRAARIAVELAKMLDGSPVTPRTVTTTTTTTTTTTSYEGFDAAGKPSAGRMINVESKEVEAKTKPEIESHPVDVLVAGSVALDLNCNYVGGAGSAESSDKVTPAMHTSNPSTIHQSIGGVGHNIARAAHLVSDEGKVRLCSMVGDDIAGHTILSTLQSSGLDTSCIRQLGHEYPSARTAQYVAVNDANKNLVMAMADMAIFSSHSFPAYWNSAVAAARPKWLVVDANWSEHDIQSWIQAGRRHGAKIIFEPVSVAKSQRLFPNLDAWRRHHHHHKHDFVIPHELPVHPRPLVDLATPNHHELLAMYQAAKAHGHLDTSAWFDVIDAFGITGRSSGRDRFDAIFSQHNARDLVDAGLPVQSISLLPYIPTLITKLGPRGALLTALLPPDDPRLRDPGHSRWVISRCAVPDHPHIGGVYMRLYPPAEKVPDQEVVSVNGIGDTFVGVLVAGLAMGGRVERLIDVAQRAAVLTLRSQEGVSEDVRGLRRVLSGIVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBS0</accession>
    <name>G0SBS0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8004 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0054570</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695791.1">
        <property type="nucleotide sequence ID" value="XM_006695728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBS0"/>
    <dbReference type="STRING" id="759272.G0SBS0"/>
    <dbReference type="GeneID" id="18259495"/>
    <dbReference type="KEGG" id="cthr:CTHT_0054570"/>
    <dbReference type="eggNOG" id="ENOG502QUVC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005053_1_0_1"/>
    <dbReference type="OMA" id="NPPWTED"/>
    <dbReference type="OrthoDB" id="5300331at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058317">
        <property type="entry name" value="DUF8004"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39601">
        <property type="entry name" value="CHORIOGENIN HMINOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39601:SF2">
        <property type="entry name" value="CHORIOGENIN HMINOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26013">
        <property type="entry name" value="DUF8004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8004" evidence="2">
        <location>
            <begin position="388"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="568"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="858"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="858"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS18846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1111" mass="122462" checksum="1039DE8476384E85" modified="2011-10-19" version="1">MATMTTSNTVPTAPTTVPATARNSVDSNALPVYPEFSHLRISSKQQLPSVGSNTSNRSQQDNTSWVTNKKVPFFTSPPSAPSMTQANHLTPWEKLADNRSPSPSHPPSMASRPQSTLLPLSAASSSYDRLRCASAQPLDGAGSWMHGISADQEVNRAVSNPIDTSRLYPPQQESSCLSPQTDSSASGTTEKRKSRMSWLPGGRSRSNSVNQPRTTTGAWLLTPESREQSDGQQQQKSVIEYSPAPLLKGEKVPELWDEMGNVYVYVHPKESGKGPCFKVPDHILASSATLTELLVTEMMATRGSLYTQDDPDTTSPKGHLYLSLGNTDVERLIDARNLFAFLLRKPLVATPKHPDLFTTVLQVAGLLRRFNFCNYDGSSFGDFVDEVFDVFIVETGIADVRNSREKTLQALILAEQMKSFNLYNEAFAHAVGKYESLLELKSPLFERISASTRQRLDRAHMDLVGRQQNAALKLEEFEFPSLFAGVASSTSHEEFRHVRFKEWRSSFHKMRSFVLGYYKTLFGSWPPRARSKRNPFSQSGLNRLALKILYSDLCALYDLLVDRTNLTPQRRSSGSKANDEGEKGSGDKEKEKEMEKEEKENERERDRERDIEANLAALRAILSEFDKSSPPVLPRIPFDVPKLPSMTALYENYRELPTKKQAKYSKSLQPHELQLLLIKSHNIDTDSLEMPFLTAFKEFELREARSASHSHIEDDLIDQRIGTWLFLYVVIQSLPMLVVDAPGLRYGDGVEYFLCEAPQGNPPWTEDRDQVRKMWYQTADQALVELSTDVVMFSVEGIYIRSHCWLAAKEWQAQAEARAASAGAVSVPVTVTQPDWATSTAITTEGAFFNPLQPPSQSIFHNADPFQTQISSSSPSPPPQHPQRHKPTVRPISTGPELDNGNGNGLLSPPLANTSLGGLPMPMGRPRAGSTHDRARQAFRASIAIGLEPIGVQPLPQMAAPLTRSPSPMMMLGQHGQGAGDSHNGEGVGIMTGVVGNLAAGQAGDDSNNSWGTPDGAKTPMVRASRSGTNLNLFGGNSSAYMGEVFPPAPAQPWVHQHQRNFSGPVAFPMPTPSSYHQHAKTSSLGGGGSTFDDILKGMDDGGKKKKRFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBV6</accession>
    <name>G0SBV6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">fumarate reductase (NADH)</fullName>
            <ecNumber evidence="7">1.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NADH-dependent fumarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0054940</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>succinate + NAD(+) = fumarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18281"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.6" evidence="7"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695827.1">
        <property type="nucleotide sequence ID" value="XM_006695764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBV6"/>
    <dbReference type="STRING" id="759272.G0SBV6"/>
    <dbReference type="GeneID" id="18259532"/>
    <dbReference type="KEGG" id="cthr:CTHT_0054940"/>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011398_4_5_1"/>
    <dbReference type="OMA" id="EDLWVVV"/>
    <dbReference type="OrthoDB" id="10252157at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016156">
        <property type="term" value="F:fumarate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000007">
        <property type="entry name" value="NADH-dependent fumarate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010960">
        <property type="entry name" value="Flavocytochrome_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01813">
        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF1">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="9">
        <location>
            <begin position="540"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00067004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00077246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS18882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="624" mass="67527" checksum="C31786D0F6469F0B" modified="2011-10-19" version="1">MAPNRVIVVGGGLSGLSAAHTIYLNGGNVVVLDKQGFFGGNSTKATSGINGALTRTQVDLGIQDSVKQFYEDTLKSARDRARPDLIKVLTYKSAAAVEWLQDVFGLDLTLVSRLGGHSQPRTHRGHDAKFPGMAITYALMQRLEELAESEPHRVQILKKARVVGLNKEGNKITGVKYEHEGQLKTMEGPVVLATGGYAADFGENSLLRKYRPDTLGLATTNGNHATGDGQKMVMEIGGNGIDLDKVQVHPTGLVDPKDPNSKWKFLAAEALRGEGGILLNSDGDRFCDELGHRDYVSGMMFKEKEKGKWPIRLVLNSKASNVLDFHTRHYSGRGLMRKMTGHELAKEIGCTPEHLQKTFQTYNAIAEGKIKDPWGKRFFHNMPFDINDTFHVSLMEPVLHFTMGGVEINDKAQVLNKEKKPFEGLFACGELAGGVHGANRLGGSSLLGCVVYGRVAGDSASNYLFQQALQSVSQPAARLGQIALHIDPSNPGKLSIEWANGAAAPAAQAAAPAPAAAAAAPAAPAAKKESSQPKPFAIPDKEFTMEEVAKHNKKDDLWVVVKGVVLDLSNWLNDHPGGPQALINFAGRDATEEFEMLHDDEVIPKYAPEQVIGRVKGQKVTLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0SC97</accession>
    <name>G0SC97_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS11m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0056440</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695968.1">
        <property type="nucleotide sequence ID" value="XM_006695905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SC97"/>
    <dbReference type="STRING" id="759272.G0SC97"/>
    <dbReference type="GeneID" id="18259682"/>
    <dbReference type="KEGG" id="cthr:CTHT_0056440"/>
    <dbReference type="eggNOG" id="ENOG502S752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072439_0_0_1"/>
    <dbReference type="OrthoDB" id="1654884at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.80:FF:000011">
        <property type="entry name" value="37S ribosomal protein S18, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="41"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="95"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS19023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="246" mass="27368" checksum="C0549A73D5FFB908" modified="2011-10-19" version="1">MSRFLTSRLLAVPDLARPLTKSILPAVSTLQWARLFSQSPAVRNDDSQQQQQPPFPVVSPLVHTGPSQQQAPTSTATTGGSMMSKLAKDVLGRAIRPSATSSSAEEDLMREVSAEEKEDDDSEEPYHFHIYSHKHNTHVTLTKPNRDVIMTLSCGNLGFRKSQRKHYDSAYQLGAYFIDKMHQRGLVKKINRLEVVLAGFGQGREAVVKVLMGAEGKHLRPKIVRVSDATKLKFGGTRSKKHRRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCM8</accession>
    <name>G0SCM8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Histidine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Histidyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CTHT_0057790</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the aminoacylation of histidyl-tRNA in both the cytoplasm and the mitochondrion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(His) + L-histidine + ATP = L-histidyl-tRNA(His) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="3"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696099.1">
        <property type="nucleotide sequence ID" value="XM_006696036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCM8"/>
    <dbReference type="STRING" id="759272.G0SCM8"/>
    <dbReference type="GeneID" id="18259817"/>
    <dbReference type="KEGG" id="cthr:CTHT_0057790"/>
    <dbReference type="eggNOG" id="KOG1936">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025113_4_0_1"/>
    <dbReference type="OMA" id="CGGGNFK"/>
    <dbReference type="OrthoDB" id="1906957at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000015">
        <property type="entry name" value="Histidyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000021">
        <property type="entry name" value="Probable histidine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476:SF7">
        <property type="entry name" value="HISTIDINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476">
        <property type="entry name" value="HISTIDYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core" evidence="17">
        <location>
            <begin position="15"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon-binding" evidence="16">
        <location>
            <begin position="385"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="302"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="80"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="282"/>
            <end position="283"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00067413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001549-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF13393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGS19154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="520" mass="57789" checksum="FCA460DE22DC9B59" modified="2011-10-19" version="1">MAPKAQKFEIKTPKGTRDWSGEDMVLREKIFKTITDVFKRHGGVTIDTPVFELKGKYGEDSKLIYDLADQGGELCSLRYDLTVPFARYLAMNKDISQIKRYHIAKVYRRDQPAVKKGRMREFYQCDFDIAGVYDPMIPDAEIIRIANEVFDALGFKGKYTIKLNSRKILDGLFQVCGVPDNLIRPISSAVDKLDKMPWEDVRKEMVDEKGLAPEVADRIGQYVVLKGQRDLLEKLKQDPELSANPSMQQGFADLELLFTYLEAFDALHTVSFDLSLARGLDYYTGVIYEVVTEGSAPSVAATKENKEKVAKKKGGKSGDPDEDRSDDPTVGIGSIAAGGRYDNLVGMFSGKTQVPCVGISFGVDRIFSIIKASQTKKSRKNEVDVFVMAFGGGKDFTGLLKERSQICARLWDAGIKAEFLYKVKPKLQAQFKAAEDGGVPFALILGEDELAQGKVKIKEMGLPAGHPLKEGELISLDNLVEEVKLRITRKQQADQLAEQADQLKLVDGVEKDNNEAQASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCP3</accession>
    <name>G0SCP3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0057940</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="12 13 14" key="2">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e56910" last="e56910">
            <title>Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation during pre-60S biogenesis.</title>
            <authorList>
                <person name="Lau B."/>
                <person name="Huang Z."/>
                <person name="Kellner N."/>
                <person name="Niu S."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
                <person name="Cheng J."/>
            </authorList>
            <dbReference type="PubMed" id="37129998"/>
            <dbReference type="DOI" id="10.15252/embr.202356910"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <reference evidence="15 16 17" key="3">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e57984" last="e57984">
            <title>Structural insights into coordinating 5S RNP rotation with ITS2 pre-RNA processing during ribosome formation.</title>
            <authorList>
                <person name="Thoms M."/>
                <person name="Lau B."/>
                <person name="Cheng J."/>
                <person name="Fromm L."/>
                <person name="Denk T."/>
                <person name="Kellner N."/>
                <person name="Flemming D."/>
                <person name="Fischer P."/>
                <person name="Falquet L."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="37921038"/>
            <dbReference type="DOI" id="10.15252/embr.202357984"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.12 ANGSTROMS)</scope>
    </reference>
    <comment type="function">
        <text evidence="1 8">Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
            <location evidence="2 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the CGR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696114.1">
        <property type="nucleotide sequence ID" value="XM_006696051.1"/>
    </dbReference>
    <dbReference type="PDB" id="8I9T">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.60 A"/>
        <property type="chains" value="Cz=1-123"/>
    </dbReference>
    <dbReference type="PDB" id="8I9V">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="Cz=1-123"/>
    </dbReference>
    <dbReference type="PDB" id="8I9W">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="Cz=1-123"/>
    </dbReference>
    <dbReference type="PDB" id="8I9X">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="Cz=1-123"/>
    </dbReference>
    <dbReference type="PDB" id="8I9Y">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="Cz=1-123"/>
    </dbReference>
    <dbReference type="PDB" id="8I9Z">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="Cz=1-123"/>
    </dbReference>
    <dbReference type="PDB" id="8IA0">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="Cz=1-123"/>
    </dbReference>
    <dbReference type="PDB" id="8PV1">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.56 A"/>
        <property type="chains" value="Cz=1-123"/>
    </dbReference>
    <dbReference type="PDB" id="8PV2">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.63 A"/>
        <property type="chains" value="Cz=1-123"/>
    </dbReference>
    <dbReference type="PDB" id="8PV3">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="Cz=1-123"/>
    </dbReference>
    <dbReference type="PDB" id="8PV4">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="Cz=1-123"/>
    </dbReference>
    <dbReference type="PDB" id="8PV5">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.86 A"/>
        <property type="chains" value="Cz=1-123"/>
    </dbReference>
    <dbReference type="PDB" id="8PV6">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.94 A"/>
        <property type="chains" value="Cz=1-123"/>
    </dbReference>
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        <property type="resolution" value="2.12 A"/>
        <property type="chains" value="Cz=1-123"/>
    </dbReference>
    <dbReference type="PDB" id="8PV8">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.91 A"/>
        <property type="chains" value="Cz=1-123"/>
    </dbReference>
    <dbReference type="PDB" id="8PVK">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.55 A"/>
        <property type="chains" value="Cz=1-123"/>
    </dbReference>
    <dbReference type="PDB" id="8PVL">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.19 A"/>
        <property type="chains" value="Cz=1-123"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCP3"/>
    <dbReference type="EMDB" id="EMD-17950"/>
    <dbReference type="EMDB" id="EMD-17951"/>
    <dbReference type="EMDB" id="EMD-17952"/>
    <dbReference type="EMDB" id="EMD-17953"/>
    <dbReference type="EMDB" id="EMD-17954"/>
    <dbReference type="EMDB" id="EMD-17955"/>
    <dbReference type="EMDB" id="EMD-17956"/>
    <dbReference type="EMDB" id="EMD-17957"/>
    <dbReference type="EMDB" id="EMD-17969"/>
    <dbReference type="EMDB" id="EMD-17970"/>
    <dbReference type="EMDB" id="EMD-35283"/>
    <dbReference type="EMDB" id="EMD-35285"/>
    <dbReference type="EMDB" id="EMD-35286"/>
    <dbReference type="EMDB" id="EMD-35287"/>
    <dbReference type="EMDB" id="EMD-35288"/>
    <dbReference type="EMDB" id="EMD-35289"/>
    <dbReference type="EMDB" id="EMD-35290"/>
    <dbReference type="SMR" id="G0SCP3"/>
    <dbReference type="STRING" id="759272.G0SCP3"/>
    <dbReference type="GeneID" id="18259832"/>
    <dbReference type="KEGG" id="cthr:CTHT_0057940"/>
    <dbReference type="eggNOG" id="ENOG502S7VB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125051_0_0_1"/>
    <dbReference type="OMA" id="NGKQWHD"/>
    <dbReference type="OrthoDB" id="3942380at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005579">
        <property type="entry name" value="Cgr1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03879">
        <property type="entry name" value="Cgr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="12 13 14" id="KW-0002">3D-structure</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="60"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS19169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="8I9T"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="8I9V"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="8I9W"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="8PV1"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="8PV2"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PDB" id="8PV3"/>
        </source>
    </evidence>
    <sequence length="123" mass="14670" checksum="07CB17FC4506AF85" modified="2011-10-19" version="1">MNMSETQVNITAAPAPATTKKNLGMRKNGQVWLPAKKAFRPTKGLTSWELRVKKRQEQAAMKAKEREMKEEKEAERQKRIQAIKERRKKKEEKERYEQLAAKMHKKRLERLKRKEKRNKLLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDD0</accession>
    <name>G0SDD0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dual-specificity kinase</fullName>
            <ecNumber evidence="2">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0051340</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="2"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695476.1">
        <property type="nucleotide sequence ID" value="XM_006695413.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0SDD0"/>
    <dbReference type="GeneID" id="18259172"/>
    <dbReference type="KEGG" id="cthr:CTHT_0051340"/>
    <dbReference type="eggNOG" id="KOG0667">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_29_2_1"/>
    <dbReference type="OMA" id="RYIDQWR"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14210">
        <property type="entry name" value="PKc_DYRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000112">
        <property type="entry name" value="Putative dual specificity tyrosine-phosphorylation-regulated kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.10.30">
        <property type="entry name" value="DYRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042521">
        <property type="entry name" value="DYRK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF22">
        <property type="entry name" value="DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="1006"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="129"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="352"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="457"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1307"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="279"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="369"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="519"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="549"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="595"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="615"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="730"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="743"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="775"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1329"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1346"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1362"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1379"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1430"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1466"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="1035"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS18531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1512" mass="163693" checksum="B5255318CD7A0E3D" modified="2011-10-19" version="1">MNREHLDPAGPIRDSQSPTRTASNASPTRISSLRRPTITDAPMLSASSSNNHSLFSFGGRNNRSDNVNNNGTSDSFDFLPSVSFDDLQTSLESASADFKLTQFPSPTGQGTILGDHALDTMGERLDTTAKRNIASSHSTTSQPALGTRSRAGSLLRRPSTSGRAVGSSTASTSTTTSNPPPISAVTRARRAQSHYPPVSGSHIAKPPRKSTGDVVLGGDIETHRRRGSIASLTDKNGLDLPRTSIDSGSRPLPDAVRAQAGSRTAKARSVQPTARSSQPTLTAETTTLAAPETTHLSTSLPRSPRVVSKTSHPASAKRISVVPGVLPPHATGLGARTISPTDAKRLKRLSMHHSQMTGSNALPNPPPLAASLDRPSSRSPSMLPRKISTPSSSTRTTPDPSRKSYSSGLSANSSSSVNNTVTVRTSTQSLQQRLSLAASRLPTPKVLGLAALGHDLEDEDVPPVPAIPKAFESPRDPLAPAPKLEKRSSNRTFDTSSIHSKSSTSSVSGTQPSETPAHKLQRRPSQRKSIHTSKLDLDTKPIAAPARKTLQPLRLPPLTLNPLNTPTAAKIAALQEQAASSDRDRDNVSPPPTKTIPKTPTTPMTASKSTFFSRRYNDDKFDVQHLRSSSSVHRLRRDTPPPLPEPQSSSESFSAVHEPTPRSGPSPFLSSSVPKGGNVEAAYLKRSKTGGDISVDTTSESPVHQQQHVSHHQHKPSDPRPPKQAAPQPAKSPPPLPSPDEPQTPSSMSSLRRKLSLSWKRNNSKNSSGQIQTEKTSETKTTKHESMPPPPPRIPVSATVGSIPAVPKPPSPTKSSITTSNYLDARRRKSSSSSLHAIMAEQRARGEGLTAAKKDSTLESVAERATALHNSSVVQKILRPKASAPVMKDDDLWVPEYDKEDMLAEEEMRKLGLRRKDTEIAARTLDALRKRATPKERVSPQEAIRIAMLNVYERGEIVDYKDIYFCGTQNANKVVGDVQSNLPNHGYDDERGDYTIVPGDHLAYRYEIIDLLGKGSFGQVVRCIDHKTGVLVAVKIIRNKKRFHQQALVEVNILQKLREWDPHNKHSMVNFTHSFYFRGHLCISTELLDMNLYEFIKANSFRGFSLRLIRRFTKQILSALNLLKKHRVIHCDLKPENILLRHPLHTEIKVIDFGSSCFEDEKVYTYIQSRFYRSPEVILGMTYGLPIDMWSLGCILAELYTGVPIFPGENEQEQLACIMEVFGPPEKHLIEKSTRRKLFFDSMGKPRLTVSSKGRRRRPSSKTLQQVLKCDDEAFLDFIARCLRWDPERRMTPEQAIHHEFITGVKPSIPRTLSPAKRVPSLTSTHGPRPLPEPPTPAKPSTLSHRMREQKDEKEGSKHQHTGSGSSTGPGPLKPAVISSSSSRRVSGMTATTIGTSGTVGTISGTTLVGSNSVKRTPSHTFHTSHHTHNSSSSTGSLASTGGITSVPSNSSLPRASLRNAGGGLSTSASVQTLNGGSSSSGATATRGHDLAAAGASAAMGMTGTAALGRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDH8</accession>
    <name>G0SDH8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD/PDEase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0051830</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695524.1">
        <property type="nucleotide sequence ID" value="XM_006695461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDH8"/>
    <dbReference type="STRING" id="759272.G0SDH8"/>
    <dbReference type="GeneID" id="18259221"/>
    <dbReference type="KEGG" id="cthr:CTHT_0051830"/>
    <dbReference type="eggNOG" id="ENOG502QSR7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036524_0_1_1"/>
    <dbReference type="OMA" id="YDNSHDY"/>
    <dbReference type="OrthoDB" id="16547at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33594:SF1">
        <property type="entry name" value="HD_PDEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33594">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03035)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="1">
        <location>
            <begin position="43"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="222" mass="24771" checksum="53FBC668750F1788" modified="2011-10-19" version="1">MSEPSPNPILSLPDVHTAFAAFQDDPLVQAVTAYVKEYMKRYDASHSWDHVERVVAMAHHIYEHSPHELKNKADLRTVHLAALVHDVGDHKYRKPEEPLLPLSELLPQITSPIPFPADLAQKLQTIIPAISYTHETRHPSQTLSLIIQHPELAIVQDADRLDAMGAVGIGRMFTYGDARGNSDGKGRSLAETMKHLDEKLLKLEGMMKTDVGKEVARVRGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDJ6</accession>
    <name>G0SDJ6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0052020</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="4 5 6" key="2">
        <citation type="journal article" date="2025" name="Cell Res." volume="35" first="296" last="308">
            <title>Structural insights into spliceosome fidelity: DHX35-GPATCH1- mediated rejection of aberrant splicing substrates.</title>
            <authorList>
                <person name="Li Y."/>
                <person name="Fischer P."/>
                <person name="Wang M."/>
                <person name="Zhou Q."/>
                <person name="Song A."/>
                <person name="Yuan R."/>
                <person name="Meng W."/>
                <person name="Chen F.X."/>
                <person name="Luhrmann R."/>
                <person name="Lau B."/>
                <person name="Hurt E."/>
                <person name="Cheng J."/>
            </authorList>
            <dbReference type="PubMed" id="40016598"/>
            <dbReference type="DOI" id="10.1038/s41422-025-01084-w"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.80 ANGSTROMS) IN COMPLEX WITH 1D-MYO-INOSITOL HEXAKISPHOSPHATE</scope>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695542.1">
        <property type="nucleotide sequence ID" value="XM_006695479.1"/>
    </dbReference>
    <dbReference type="PDB" id="9L5R">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="F=1-233"/>
    </dbReference>
    <dbReference type="PDB" id="9L5S">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="F=1-233"/>
    </dbReference>
    <dbReference type="PDB" id="9L5T">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.50 A"/>
        <property type="chains" value="F=1-233"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDJ6"/>
    <dbReference type="EMDB" id="EMD-62841"/>
    <dbReference type="EMDB" id="EMD-62842"/>
    <dbReference type="EMDB" id="EMD-62843"/>
    <dbReference type="SMR" id="G0SDJ6"/>
    <dbReference type="STRING" id="759272.G0SDJ6"/>
    <dbReference type="GeneID" id="18259240"/>
    <dbReference type="KEGG" id="cthr:CTHT_0052020"/>
    <dbReference type="eggNOG" id="KOG3407">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091076_0_0_1"/>
    <dbReference type="OMA" id="MLVQGIH"/>
    <dbReference type="OrthoDB" id="10261348at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013169">
        <property type="entry name" value="mRNA_splic_Cwf18-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31551:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31551">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08315">
        <property type="entry name" value="cwf18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4 5 6" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>1D-myo-inositol hexakisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>1D-myo-inositol hexakisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="9L5R"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="9L5S"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="9L5T"/>
        </source>
    </evidence>
    <sequence length="233" mass="25322" checksum="D17E0A634C297326" modified="2011-10-19" version="1">MSSYSSLSAAADERKARLAKLASLKRKQPEDDHPPSQDQQPEQSAAESKQEGDSSQASDPVLQHLSLRNYDPVTRGPKLGFEAPPTENLNTLTLEEKAAALEAEARRKAQEEQEAAAQARGLDITTLQPKKPNWDLKREFKQRMAVLDVRTENAIARMVRERLAEKKKAIVGASAAASGAADGAASGGGNNGKGEEGVLEGAEILEGMRMREKEEEEEARREKEAEEAEFGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDL8</accession>
    <name>G0SDL8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Calcium-dependent cysteine-type endopeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0052240</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695564.1">
        <property type="nucleotide sequence ID" value="XM_006695501.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0SDL8"/>
    <dbReference type="GeneID" id="18259262"/>
    <dbReference type="KEGG" id="cthr:CTHT_0052240"/>
    <dbReference type="eggNOG" id="KOG0045">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006072_1_2_1"/>
    <dbReference type="OrthoDB" id="424753at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000072">
        <property type="entry name" value="Cysteine proteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF379">
        <property type="entry name" value="CALPAIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="8">
        <location>
            <begin position="238"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="181"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="741"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="995"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1162"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="193"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="756"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="770"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="802"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="812"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="833"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="855"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="926"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1003"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1088"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1112"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1180"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1195"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1214"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="460"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS18619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1341" mass="152054" checksum="600C008FDF18A958" modified="2011-10-19" version="1">MSRHSFRPPGPMPMGPPGMTIPNRGVNPLRTPQDKVDEFWEKFTTKAPGKGRFILNKRLSWTKDRFIFFPITLLPKNELTEKLAKRSAAKDLAGGETTATTRSYEEAAALCKAKVAQIVSECRRVNQKYRDPHFDLDFDLRTGRRDCLESLSNDKGDYYYPSDSDSEDSITSYYRGVRGSGDLGRVSNKTRNVRKDQAAGGEKKEGAETSGLTEFADGYGTRCRSRWPGADLKPQSVKRVGEIFDDPKFFIEGPSANDVRQGHNGDCWLMAALCTLSNKPGLIERVCVAQDPDVGVYGFVFHRDGEWFSEIIDDQLYLIKPDYDQAFTENGDRNLDRILWDKVQRDEDTEEIYRKTYQSGSSALYFAQCAHPNETWLPLLEKAYAKAHGDYAAIEGGYVGEGIEDLTGGVTTSLFTADILDKEYFWKEELMKVNQDFLFGCATGLWGLGWGERRGIQEHHAYSIMRAVEIDGQRLLLLKNPWGKGEWKGAWSDGSKEWTPEWLKKLNHRFGDDGAFWMSYKDLLRKFTTFDRTRLFGPEWRVTSMWTTLNVPWAREYHHTKFSFTLAKKSSVVIVLSQLDSRYFRGLEGQYRFGLAFRVHRAGEENYLVRTHTNFLMTRSCNVELELQAGEYTVLVKLDATRVDGLLPPEEVVRLNVKKRREKLLRIGLAYDIAHSKARIVETEEEKAAREAYEKRKREKLRKKLRKELNERRKEDYYLSWKKTREEWKTKARDRKVEKKLNKKLHDKRMAAKERAARKRREKMAKKVKRAEDEKEDEPSGKEIVDKKQEQLQKEKDDKAVNQHQSDGNDSADTRNEEEKSTETKAGIAQQQSHEEKPAKVTTDESKSVDDEQESASNASEGAEATPSSSSRPAADVAHQNPEKRSEEAPSTPESAILSAKSNTTDKKPNTVEPSTEEAACSTKTAAERTGGDESKPSEDKPASPKDSQVPVHEASGDKGPAGSKRATKADQPELEAKLRKALDIISAFKSELEGLLGGEGASKGRQDDRDDHDKTKDEVESHPDESIHKPPHTRDQPDHESTHEADQATHRSEPEESEDEFSDHGSPSPSDYDFSLPSLSDVSDTELEQHVKAYEESEKLGSGGLNRPAQVVLPGPGLESVPPPPGIMPGPSGDDEPEPWNAVAVVGLRIYYKVSEEDKDTEGLVKIKVVRPDPWAISDSEDEEDDEGEEGDDEKEKREEEKKEECDSQDVEAENKSEERSKEEVEGIKGEDEKNHVEEKEAKQEDEKVEKKEEKEKKGNEEASKEREKNDDRKRPKLEKQDSKAPKLERNDSGRTPKFERKDSGRIPRLERRESSRVDEARVLDVDDSAKDAALKGEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDV8</accession>
    <name>G0SDV8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative nuclear fusion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0053160</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695654.1">
        <property type="nucleotide sequence ID" value="XM_006695591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDV8"/>
    <dbReference type="STRING" id="759272.G0SDV8"/>
    <dbReference type="GeneID" id="18259354"/>
    <dbReference type="KEGG" id="cthr:CTHT_0053160"/>
    <dbReference type="eggNOG" id="KOG4568">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003115_0_0_1"/>
    <dbReference type="OMA" id="KWCAVCE"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032108">
        <property type="entry name" value="CLIP1_ZNF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF83">
        <property type="entry name" value="TIP ELONGATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16641">
        <property type="entry name" value="CLIP1_ZNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CAP-Gly" evidence="8">
        <location>
            <begin position="205"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="260"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="611"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="708"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="808"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="286"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="328"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="708"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="733"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="812"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="860"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS18709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="925" mass="97341" checksum="279BD88C18BA456B" modified="2011-10-19" version="1">MSSTATATASTSTSLTSTLPLPSVPPSTATSTYASTTRHTLSRRPGRRGIVTASTPNLNQLYTAHAASSATPSTLIRAASPALSVYSAFPAPSNANANASSLNTTTSSSHAPSHSSRLAPPALSRKGSYAALTPSTLAAIPDDSDTYPIKSVLTSDMPTPISPAAGAGGRYSAVGAGASAADDPVTIGDTVEVPGNMLGTVRFIGPVTGRKGIFCGVELHPEFASRGKNSGDVDGVYYFTTAQPGSGIFLPLSKAIKRDPPPVAPATSYPISPTGGGLKASGIASKFSQSLGPGRSQSPIGKKVRPSGGLQRPESPVRRLTSPAPSRPSITTAPKATPTPSRFGSPTSTSKFSQSVRSSAGDPNKRVTPSHTRKGSMSIGPRSASVLGTVSQPSLTDDEGTPRGSNGGYGGPSSFALKVRPASRSTSQAGTHTTAEDEIERLRAELEDRDRQLREQAQTLAEMEASLNELQGIIENSEGPPVQQRRNSLDDKDVSQLKALIREKNDKIAMLTAEFDAHRADFRSTIDTLEMASAETERVYEKRIEELMEEIRELQERTADVDTVAAQLKQLEELVQELEEGLEDARRGEAEARGEVEFLRGEVERTRAELRREREKASVAGNGSVSKELEQKEDEIRGLKAIIHSLSRDSVPGGEGADRALAQNAAGQSASIDDRLARERLEREVAELRALLESKTAREEELERELEQLRRGQAARHERDRSSIRDSRATVVGPSSSSQEGGTSAQAAGRAGSKANANGGLDTLESDTYSTATDHSTLWCEICETSGHDILSCTNVFGDKGPQRAALDKQDATSFSSNRDTLTLPVRTRGGASSTAGDSDTLGIEDDPSAKPAPLSPMRPAAAKPASSTAGSSSAAGTGLRQLPNPHDNGPVAGKESGVVDASKWCALCERDGHDSVDCPFEDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDW3</accession>
    <name>G0SDW3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Putative DNA repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CTHT_0053210</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Single-stranded DNA endonuclease involved in excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Essential for the incision step of excision-repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the XPG/RAD2 endonuclease family. GEN subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695659.1">
        <property type="nucleotide sequence ID" value="XM_006695596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDW3"/>
    <dbReference type="STRING" id="759272.G0SDW3"/>
    <dbReference type="GeneID" id="18259359"/>
    <dbReference type="KEGG" id="cthr:CTHT_0053210"/>
    <dbReference type="eggNOG" id="KOG2520">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003018_0_0_1"/>
    <dbReference type="OMA" id="PNSMDFS"/>
    <dbReference type="OrthoDB" id="31113at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048256">
        <property type="term" value="F:flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09904">
        <property type="entry name" value="H3TH_XPG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09868">
        <property type="entry name" value="PIN_XPG_RAD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000025">
        <property type="entry name" value="DNA repair protein RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000030">
        <property type="entry name" value="Flap endonuclease GEN-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000061">
        <property type="entry name" value="Single-stranded DNA endonuclease (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001044">
        <property type="entry name" value="XPG/Rad2_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171:SF7">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00066">
        <property type="entry name" value="XRODRMPGMNTG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="17">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="16">
        <location>
            <begin position="889"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="421"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="775"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="836"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1156"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="114"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="460"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="591"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="606"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="630"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="709"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="738"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1189"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="1223"/>
            <end position="1238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGS18714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1238" mass="138717" checksum="FBB3309CE5FDD8A8" modified="2011-10-19" version="1">MGVQSLWTILSPSARPTDLATLNRKRLAIDASIWIYQFLKAVRDKEGNALRNSHLVGFFRRICKLLWYGVKPVFVFDGGAPALKRATLQARRRRREGRREDAARTAGRILAVQMARLAEEEREKRKRLAEAGNEAARREVEEEQERLPAMEDIVYADELGMSRQERLRNRKFRKEDAYHLPDLDMSIEEMAKPNDPRIMSLEELEEYARQFQNGADINLYDFSKIDFDSDFFKSLPAADRYNILNAARIRSRLRMGLSKEQLNQMFPDRMAFSRFQIERVKERNRLTQRLMYEMGMAGTDLTIGPNRIASDRNREYILVKNEGAEGGWALGVVSREKDVGQRHKPIDVDALDVKYEKESEDEELEDEEFEDVPIEGLNRLPKPKMESLGVDREEGGLFVENGEDLFEDEGDEDLNRAVALSLEDQHRANEDEDEDEGLRRAIAMSLEKQHGVKAGPEPAGAEEIEAEEEEPESPPPEWKQRAVEPAKPITSTDGRVVAHIVNNRAIAAVPRRRQSESSDSEVDLQAALAAARKKQTKSEPKPQPMQASAKATKSPFDGPLPFEKLDWRGMLSAKASSARKEAETGHVTETGELEAESEDEAGGFIKEPEESASNDKMKPLPLPPWLTDTTDIRESLRKEQEREAEMNARAEKMEAEFRFGQGRDDEVIEIGSSSSDSDVEILNAPPKPAPVQKAPSPEPGASLPSLADLLKENAERAAQEEALKTKSATPEKVQAESVEAEAEAEVKADEDEDAVFEDVSLPTARKLTVEITESVPVPSEPIGETAATLAPHEEDVPLEESTSIDPDAPAAEEFSDFSDPEDEALLAQLAEEAEEHARFASQLNNKSVRENQQDYEQELRSLRSQQKRDRRDADEVTQVMISECQTLLQLFGIPYITAPMEAEAQCAELVRLGLVDGIVTDDSDTFLFGGTRVYKNVFNSNKYVECYLASEIESELSLSREQLISLALLLGSDYTEGLPGVGPVTALEILSHFPPGDKQALIQFAEWWTDVQQRGRPASADASSPWRTKFRRAHATKLFLPPGWPSPAVWDAYLSPEVDSSPEPFQWGVPDVEGLRRFLMGTVGWGKEKTDEVLLPVVRDMNRREVEGTQMNITRWVTGTVGAGVMGEAFAPRVRQGGSKRMARAVERLRRGVAGGNIGEGVEQEGQVDTSRTENICKRGRKRKAREVVEEEEEEKEGDEGDVEEYGEEEDGEYQAESEARKTRGRGKGKARGKKSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDW7</accession>
    <name>G0SDW7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0053260</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695663.1">
        <property type="nucleotide sequence ID" value="XM_006695600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDW7"/>
    <dbReference type="GeneID" id="18259364"/>
    <dbReference type="KEGG" id="cthr:CTHT_0053260"/>
    <dbReference type="HOGENOM" id="CLU_2637858_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="77" mass="8321" checksum="A4DCFBF24936CA4A" modified="2011-10-19" version="1">MSANKRSMWRQDAVDIASAAAQKQKRIRKPTLIGTLPGTRDSSSSLEPGIPTRVSQELSQSEELIKGRSMAAGPVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDY8</accession>
    <name>G0SDY8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0053480</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695684.1">
        <property type="nucleotide sequence ID" value="XM_006695621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDY8"/>
    <dbReference type="GeneID" id="18259386"/>
    <dbReference type="KEGG" id="cthr:CTHT_0053480"/>
    <dbReference type="eggNOG" id="ENOG502SGHJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_284285_0_0_1"/>
    <dbReference type="OMA" id="TVKCPWC"/>
    <dbReference type="OrthoDB" id="5386674at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="604"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="457"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="605"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="701"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="726"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="757"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="813"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="914" mass="98961" checksum="8AD9467B51ACDE20" modified="2011-10-19" version="1">MDSFLNFSHKPPSRFSPQYSSMTDVAWQQTDDLPYSSSSSFYTAPELDYSHEPQYLELPPPLQQFPQRSSSLSQYQRQHQHQHYHQYHHPYQNQYQDQYQHNQYTMATVAAQRPPLHVTIPTTPLEGGQTRAQNDQRDGQDSDPTTPTQKQKVKFLEDDDDSDSKSDQSSICQSPSWEGYGKKKKDKKKEKKQVEKEVKKKRSPARLSKLPPPTTPNGSRPSGLTNADRSKSDTVLSQNWQQGTLRPGPRLEDIGRAVSTDDFDQGENHWTGAAGDQASSGIQPRNVPRPPRDAYPPAGSRTPQANSRSQQGSPDRNRSQESLAGDGYVLQHRAQATARALANVADEQLMHAIENYAPSIHELNQSSRRTSLAVDPKAAALWLVGKRPRSRTRQDEIAVGDNDILSFKAVPYSQSSASMPPPKFVDTVPNKGKLSPEEIADLLAKAKVKDEKRAASRRASQSPRQSPTQRPQDVAPNATTTTTTTTTTTATKTTAAASPSSAPAKSNETSQQSENSSSSSVLGDVSPLPSRTSTPDTSRPQSAKDVPIFGEQAQDKTEKKGNGQSSEQRRRQGSDSDGSRSSYPIDLDAYTYVTPLVLNNEKEAQASQAVAGAASTSAPKPESQAPEQQQQQQQQSEAARKPGSSSETPDPERPKSRSQSLPRKGKARAAPAPLHLDGNNSDSQQLPLKPALKSPRRIPGSPLSSAAPSTRASSPARSPLRSEFSVPPPPPPPMPHSPGLPPADMASLQPPSFPGSRPTSSHASGASTPSQRTSNASGPVSILKNGNSNGKAPAAPSDALARTSGLPRHLQRPGTATPSSSTSGSNPGMMMSMPPAMPVGKMFVECCNCHFYHDMPAKIYECMARPDAVVVADEESGLSGQVTTMVRCPWCGHPMSRGCCAGYVAVVYIKERLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEB9</accession>
    <name>G0SEB9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication licensing factor MCM2</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">DNA replication licensing factor mcm2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Minichromosome maintenance protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CTHT_0063200</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696627.1">
        <property type="nucleotide sequence ID" value="XM_006696564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEB9"/>
    <dbReference type="STRING" id="759272.G0SEB9"/>
    <dbReference type="GeneID" id="18260358"/>
    <dbReference type="KEGG" id="cthr:CTHT_0063200"/>
    <dbReference type="eggNOG" id="KOG0477">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000995_0_1_1"/>
    <dbReference type="OMA" id="TYERVTT"/>
    <dbReference type="OrthoDB" id="844at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17753">
        <property type="entry name" value="MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000002">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000138">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008045">
        <property type="entry name" value="MCM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF44">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12619">
        <property type="entry name" value="MCM2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01658">
        <property type="entry name" value="MCMPROTEIN2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="20">
        <location>
            <begin position="490"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="143"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="697"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="869"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="707"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00074927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00078186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EGS18296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="893" mass="99722" checksum="DD8B796D8154DE81" modified="2011-10-19" version="1">MSSPLRENPSSANRGPAPNRAGRKRARADAEDGSPAGAPSSPIMPSSPPAFNIAHGNDNNDDDDIEEDVEIPDDIDDLEEMAEDDIDLFQEGFERDYRERPDDRYEDIDIDDEEYDAMDIGERRRLEAKLNRRDREVARRQRIPAAFLPGEDEGDIDLTAQPRRRRRRYDEDPDEDMEGDIMEEELSLEALHDFKASSLTEWVSQPAVQRTIKREFKAFLTEYIDESGSSVYGNRIRTLGEVNAESLEVSYEHLANSKAILAYFLANAPAEILKLFDEVAMDVVLLHYPDYERIHAEIHVRIYDLPVQYTLRQLRQSHLNCLVRVSGVVTRRTGVFPQLKYVKFDCTKCGVTLGPFQQESNVEVKITYCQSCQSRGPFTLNSEKTVYRNYQKITLQESPGTVPAGRLPRHREVILLWDLIDKCKPGEEIEVTGIYRNSYDAQLNNRNGFPVFATILEANNIVKAHDQLAGFRLTEEDEHRIRQLSKDPHIVDKIINSIAPSIYGHTDIKTAIALSLFGGVAKTTKGAHHVRGDINVLLLGDPGTAKSQFLKYVEKTAHRAVFATGQGASAVGLTASVRRDPLTSEWTLEGGALVLADKGHCLIDEFDKMNDQDRTSIHEAMEQQTISISKAGIVTTLHARCGIIAAANPIGGRYNSTLPFSANVDLTEPILSRFDILCVVRDQVDPEEDERLARFIVGSHSRSHPMSATNPRTNPNAAGNANNTQASSANGGDSMEVESDTQAAANAAAAKEEKEGEIPQELLRKYILYARERVHPKLYHMDEDKVARLFADMRRESLATGAYPITVRHLEAIIRIAEAFCRMRLSEYCSAQDIDRAIAVTVDSFVNSQKVSCKKALARAFAKYTLARPGGPGSTGNRLRGNRRVESQAQVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEF3</accession>
    <name>G0SEF3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b-c1 complex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0063540</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the UQCRB/QCR7 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696661.1">
        <property type="nucleotide sequence ID" value="XM_006696598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEF3"/>
    <dbReference type="STRING" id="759272.G0SEF3"/>
    <dbReference type="GeneID" id="18260392"/>
    <dbReference type="KEGG" id="cthr:CTHT_0063540"/>
    <dbReference type="eggNOG" id="KOG3440">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115154_1_0_1"/>
    <dbReference type="OMA" id="MAKWEAN"/>
    <dbReference type="OrthoDB" id="425749at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1090.10:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1090.10">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003197">
        <property type="entry name" value="QCR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036544">
        <property type="entry name" value="QCR7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02271">
        <property type="entry name" value="UCR_14kD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000022">
        <property type="entry name" value="Bc1_14K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81524">
        <property type="entry name" value="14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS18330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="129" mass="15017" checksum="803A4B2FEF05BD0E" modified="2011-10-19" version="1">MPVPAPSLIDAVVARPWLARLLKPVANWYVNAAGYRQMGLRADDLICEEDERVLKALKRLSPKENYDRVYRLRRATQLSLQHKLLPKNEWTKPEEDVPYLTPVLKQVVAEEKERHALDTLEVVRRKGQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEV0</accession>
    <name>G0SEV0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0059790</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS17966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696297.1">
        <property type="nucleotide sequence ID" value="XM_006696234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEV0"/>
    <dbReference type="STRING" id="759272.G0SEV0"/>
    <dbReference type="GeneID" id="18260017"/>
    <dbReference type="KEGG" id="cthr:CTHT_0059790"/>
    <dbReference type="eggNOG" id="KOG2707">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023208_4_0_1"/>
    <dbReference type="OMA" id="NAAMIGC"/>
    <dbReference type="OrthoDB" id="10259622at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072670">
        <property type="term" value="P:mitochondrial tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="8">
        <location>
            <begin position="179"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Gcp-like" evidence="8">
        <location>
            <begin position="297"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS17966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="486" mass="53585" checksum="2D207E1EBAAE8983" modified="2011-10-19" version="1">MRSFITRLAPRLATRIPRRYYSSDPRDPYGPFDKAPVVDPPAPETLVTLAIETSCDDTCVAVLEKCGSAARLLFEKKVTSDNKIYGGVHPATAVESHTAAVAPLVREAIRYLPNRQPGKRSFQYRKMTTGDIIAFKRLPDFVTSPSTTCKPTLSPLAWSTPSASPGPKPPQPKAPSYNPDFPFLTLLASGGHTQLVLSNSLTSHTILADSLNISVGDMLDKVGRTLLPPDILDAANDVMYAAQLERFAFPVPDPTPSNPSPKPDYSWYEVPPTRADEIKLFFPPEPYKWSLTPPLSQSRDMAFDFSGLGGQAQKILTQDPNRPLESIPIEERRELARGVMKLAFEHLASRVLFALQDMRGAVPHRSKQHPSNLQAAKKIGTTRARNIRTLVLSGGVASNAFLRKVLRDMLDARGFDDVEIVAPPPQLCTDNAAMVAWTGMEMYERGWQTALDVLPVRKWPFDPAQSGGGIMEIGGWMEWMPQGVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEX9</accession>
    <name>G0SEX9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutaredoxin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0060080</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS17995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696326.1">
        <property type="nucleotide sequence ID" value="XM_006696263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEX9"/>
    <dbReference type="GeneID" id="18260046"/>
    <dbReference type="KEGG" id="cthr:CTHT_0060080"/>
    <dbReference type="eggNOG" id="ENOG502SC8X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125054_0_2_1"/>
    <dbReference type="OMA" id="SDVWDKR"/>
    <dbReference type="OrthoDB" id="429967at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008554">
        <property type="entry name" value="Glutaredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052565">
        <property type="entry name" value="Glutaredoxin-like_YDR286C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33558">
        <property type="entry name" value="GLUTAREDOXIN-LIKE PROTEIN C5ORF63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33558:SF1">
        <property type="entry name" value="GLUTAREDOXIN-LIKE PROTEIN C5ORF63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05768">
        <property type="entry name" value="Glrx-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="109" mass="12463" checksum="FEEAF6FA4B01744D" modified="2011-10-19" version="1">MLRVTNRLLQSCRITLFTRANCGLCSQAKSVLSDVWDQRPFVYKEVDIIAPEAKGWRDLYEFDVPVIHISKADAPEEDPKQSSKAVKLMHRLKVEEVMAKMDVVEGKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0SF53</accession>
    <name>G0SF53_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0060840</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696400.1">
        <property type="nucleotide sequence ID" value="XM_006696337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SF53"/>
    <dbReference type="STRING" id="759272.G0SF53"/>
    <dbReference type="GeneID" id="18260122"/>
    <dbReference type="KEGG" id="cthr:CTHT_0060840"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_5_11_1"/>
    <dbReference type="OMA" id="PAKMNRD"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="522"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS18069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="579" mass="67104" checksum="A9E8D14A319DD741" modified="2011-10-19" version="1">MATFNVNNVNDGNIQTVSINHRRGAPRRMVSPDRYIHREISVVVFIGLALFTAGIHCFIVGAYTVHRVSRIIGAHILFAAVFYVFGWRCYIHPYYWSELRHIPTVPGCPIWGQFFDIITEECGVPQRRWHHQYGPYIRYFFPFGAERLSIAGEEGLRHMTQRNPYNYPKPVRAKKWMERILGEGVLLAEGETHALQRKALAPAFSGPGIRALTPVFWEKAVLMSKVWKESFERQNKKVLSVEVLDWLNRCTLDIIGKAGFGYEINSLTERNNNVRRAYQLVFNFSPSARIQHGVQAFWPVTKHLPTQMNRDVEEARSIIIDKAMEILNARLNEAENNRGGKDILTLIARENKNIKASGEEGLSFDEMRDQVMTFLGAGHDTTATAVTWALHLLAQHPEVQEKLREEIRKHFLFLFEEATRNDPKNWYHDPHKLPYLEKVCRESLRFIPPIPMTVRQTVTDDQIGPYFIPKGTVIYMLANVTNRLKDFWGPTADEFNPDRWDELPDTAQGHAYFTFLAGPRSCIGRKFAETEMKILLCALLSKYEFYPNFEWEDPEEHKMWRLVLRPLEGVHLHAKILEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFB4</accession>
    <name>G0SFB4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3'-5' exonuclease-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0061450</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696461.1">
        <property type="nucleotide sequence ID" value="XM_006696398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFB4"/>
    <dbReference type="STRING" id="759272.G0SFB4"/>
    <dbReference type="GeneID" id="18260183"/>
    <dbReference type="KEGG" id="cthr:CTHT_0061450"/>
    <dbReference type="eggNOG" id="KOG4373">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016103_0_0_1"/>
    <dbReference type="OMA" id="DVRSSNW"/>
    <dbReference type="OrthoDB" id="1920326at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06141">
        <property type="entry name" value="WRN_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051132">
        <property type="entry name" value="3-5_Exonuclease_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620">
        <property type="entry name" value="3-5 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620:SF104">
        <property type="entry name" value="EXONUCLEASE 3'-5' DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="4">
        <location>
            <begin position="170"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS18130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="565" mass="63488" checksum="02F8A609A02018CF" modified="2011-10-19" version="1">MAALNQKCQLWDVSRGIVFAGEPKVFYPNLVMESYHTAAATATDSEAQSACVAVASMGEIAKKPTRRRRKLVVSDVEVTATEEPVTMSHTSASAEEEPVPEDGEEVEEPIGNTIKKQPENSSTMVPPFTPLPFKMPEELFRAAKQAAEGSPQSFWSYSMYRGPDDERVKVHYCTSQYTTERVLQNYFAHEEVLGFDLEWETNATRSRGPRKNVSLIQIASPSRVGLFHVAKYPCKGSLVPPTLKQIMENPKITKVGVAIKGDCRRMEQHLDIKCRGILELSHLYKLVRFSRTGEYNLINKRLVSLAFLVEECLGLPLFKGADVRTSHWANVLDADQIEYSASDAYASVQLYFVLNHQREQLNPVPPLPPHAELDLPLRHAGNDYLFAEDSEAQSPTEDTTDPLNASTTAKQTDVVNSNDPANIDNLVEAFDDPNVHPLLNAAQKKAYRLCFTRQDIRISPIRLRAYYLWYDNPDLKPEKISEILRDPPLATITVVAYILDSLHTAGLPYDKERLRDEVLVHVTPEVRAKAWWRTKSGDVWVKPFEKEGLLPVRSQESGEPVGTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFI8</accession>
    <name>G0SFI8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0070980</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697371.1">
        <property type="nucleotide sequence ID" value="XM_006697308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFI8"/>
    <dbReference type="GeneID" id="18261136"/>
    <dbReference type="KEGG" id="cthr:CTHT_0070980"/>
    <dbReference type="HOGENOM" id="CLU_1467984_0_0_1"/>
    <dbReference type="OrthoDB" id="4790198at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409139" evidence="1">
        <location>
            <begin position="22"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="184" mass="20297" checksum="8CD293EC7995733A" modified="2011-10-19" version="1">MRPTSLPIFLLLSSPITPALSLPSLPTTLTTNIAISLARIHSIPIPPSLLEASALNIDVWGPIPDDAVRVPLPNSTDLYGFLSEPGTRANVWARAQGELDKFEEELRRWEFIGGLERRQRGIGNGKNFYIPNLQYDIYYAPPLGSGDYAAIANRREQGVWPARGAPEEKAFERFVGEVVRESGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFK0</accession>
    <name>G0SFK0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0071110</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697383.1">
        <property type="nucleotide sequence ID" value="XM_006697320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFK0"/>
    <dbReference type="STRING" id="759272.G0SFK0"/>
    <dbReference type="GeneID" id="18261149"/>
    <dbReference type="KEGG" id="cthr:CTHT_0071110"/>
    <dbReference type="eggNOG" id="ENOG502S0C3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037393_1_0_1"/>
    <dbReference type="OMA" id="SWKPAYL"/>
    <dbReference type="OrthoDB" id="2157866at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13298">
        <property type="entry name" value="PH1_PH_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13299">
        <property type="entry name" value="PH2_PH_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000286">
        <property type="entry name" value="PH-protein kinase domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336:SF15">
        <property type="entry name" value="DUAL ADAPTER FOR PHOSPHOTYROSINE AND 3-PHOSPHOTYROSINE AND 3-PHOSPHOINOSITIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="51"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="293"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="483" mass="51802" checksum="9B19F2361CA49264" modified="2011-10-19" version="1">MVMSDAQTHSRTPSSSGVQPNLDTSQPPATSSTTRKTPISVSPSGCFATDRILKSGYVHKRTQKTKTWRTIYIVLRPTTLSIYKSDKEEKLRRKIDLADLTAVTLLKDPKGKRQHLFGLFSLSKNYYLQAPTEKDAAEWVELIRSEARIDEEEEELFLASPPVRQGSFLQAGNFASGSLSATEGRSPVARAVPDRWVSSSPEPMELPSRTSLKPPSAGRRMSQIDSSGLSGAEFATHSDFSDWEPTRPGIKGTSFESLGALHPVPEGEGPDAVPADPKRSSTGPHPDPSEADRVIWQGYMYLLRTPAPGVKQWKKAWAVLRPRNLILYKDSAESSVLFVLYMGAIVNVVETDPLSKKKRHCLQIITDEKNYRFCCRDEEELVQCLGGFKSLLAKRREIEKGRAAAAQAGGSGNGSGRSSAGGENSRGGRQGTGGGGGLMNVATAIVMANAAATATGAASAITVGEGKSGGEWSSGGLASSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFL6</accession>
    <name>G0SFL6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative DNA repair and recombination protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0071280</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697399.1">
        <property type="nucleotide sequence ID" value="XM_006697336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFL6"/>
    <dbReference type="STRING" id="759272.G0SFL6"/>
    <dbReference type="GeneID" id="18261166"/>
    <dbReference type="KEGG" id="cthr:CTHT_0071280"/>
    <dbReference type="eggNOG" id="KOG0387">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_7_0_1"/>
    <dbReference type="OMA" id="PTWTGQF"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000094">
        <property type="entry name" value="DNA excision repair protein ERCC-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="402"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="713"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="218"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="261"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="903"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1057"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="42"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="272"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="922"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1057"/>
            <end position="1086"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS17781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1159" mass="130417" checksum="AF96849D58F14154" modified="2011-10-19" version="1">MDNESGTPATFATPPEAQASQASSVPAEPVAPATVINKPMALDAVTDEVEALKDLTENVRDQDDLERDITYQASIALIEAENKKDVKRIEKVENTKSKLESQLKAQQQKLSARHANPTSRLRIQKEIARLQAEIELCDKDIAAFRARIEQRTKEGVGSDGKAVSVGGRLPNETQREYLIRTGKITPFATFGGPRPDDVAGELAEAIIDAEEEAIAEELEEQMEEGPRSHQNLRLPGFVQDNDDDDDDVFSSAVKSEFSLRPRKKRKIRQVEDEGSDDEFVPEESASEAATSEDYETDDFELDEQTPKRKRGKIVKATEEEKIDLSKIDDGNESVYQRRLKSWVQRRSRARRRHRERLGYPAGEGSDDEEEWFKPLPDTPDYQFEGGLKLPGDIYPALFDYQKTVQLISFVAALHYSKKLTKPVIVVAPATVLRQWVNEFHRWWPPLRVSILHSSGSGMFNVRDEGEIEELVEDWNEEKKKPTRSNKAAKQIVDRVVKHGHVLVTTYAGLQTYGDILIPVEWGYAVLDEGHKIRNPNAAITIYCKELRTPNRIILSGTPMQNNLTELWSLFDFVYPMRLGTLVTFRAQFEIPIRLGGYANATNLQVMTAQKCAETLKEAISPYLLQRLKVDVAADLPKKREQVIFCKLSPEQRQAYELFLKSPEMAAILNRTRQSLYGIDILRKICNHPDLVDPKLKNKPNYKWGSVEKSGKMAVVQSLLPMWKRLGHKTLLFCQGTQMLDIIEAFVKTLDGIKYLRMDGKTPIKLRQTLVDQFNTDPDLDVFLLTTKVGGLGVNLTGANRVIIYDPDWNPSTDVQARERAWRLGQKREVTIYRLMTAGTIEEKIYHRQIFKQFLSNKVLKDPKQQTAFNLNDLHDLFSLNSYEDGVTETSELFKSSGTKTFASGPKELVVPGNKDAPVLVFRDSKSNPKSKEGDDSPSTEDKELDDLHNIDGVAGLETYQSASEPEDKPAEKEDRLLEGIFARSGVHSTVEHDEIINGSNKKPRADPRMLRQEADRIAAQAAQHLRRAGEQARTIPIGTVTWTGEVGEAGRPVNVRRAAQQQARGVRSGATSSASSSRSGTPASTGHGLTVRDFERMIPPFIKRHGGQVPSKLLVDHFNHYCSTTQQANEFKIALGKVAQMEKKGGSMRVIWTLKPAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFU8</accession>
    <name>G0SFU8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Defective in cullin neddylation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0072200</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697481.1">
        <property type="nucleotide sequence ID" value="XM_006697418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFU8"/>
    <dbReference type="STRING" id="759272.G0SFU8"/>
    <dbReference type="GeneID" id="18261258"/>
    <dbReference type="KEGG" id="cthr:CTHT_0072200"/>
    <dbReference type="eggNOG" id="KOG3077">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047042_1_0_1"/>
    <dbReference type="OMA" id="LWCKFLQ"/>
    <dbReference type="OrthoDB" id="27198at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014764">
        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281:SF31">
        <property type="entry name" value="DCN1-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DCUN1" evidence="3">
        <location>
            <begin position="42"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU410713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS17863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="289" mass="33222" checksum="51E1DB712B815A5B" modified="2011-10-19" version="1">MPRTPKPKANASQQKPYAKGTSSARYFDSKDAGYARGSREDPTEKALKQLFDSLSGGANELGLEQIAGYADALGIDANSFELFVLTDLVKVESMGQITRDGFVNGWKQFYESNRRVTPSLESQKQHIRGCIDQCRSNPEYFKKVYRSAFLAGKEAGKREMEIPIAFTYWELLFEPTLRGWRSTHVDFFTHWKEFLRQRFRSEEKARKDAEKRHAVDPDEPLEVLETDGWTRTISKDLWNQTLLFAYKTLEDETLGFWSEEQAWPGLIDDFVVWCKKNGVVKGDGMDVDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFX9</accession>
    <name>G0SFX9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0072530</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697512.1">
        <property type="nucleotide sequence ID" value="XM_006697449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFX9"/>
    <dbReference type="GeneID" id="18261291"/>
    <dbReference type="KEGG" id="cthr:CTHT_0072530"/>
    <dbReference type="eggNOG" id="ENOG502T143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1085868_0_0_1"/>
    <dbReference type="OrthoDB" id="5226619at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409124" evidence="2">
        <location>
            <begin position="19"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="256" mass="28477" checksum="75F3191D84D194C5" modified="2011-10-19" version="1">MLLKLLFTFITFALSVAADEDYNPPPLPDLLPWEVTYLKTWSPSGRPGTYPFSNIELTIRDPNNLTLGWFYGDRRIGWGPSSANCSLKWLRDIIPSEGYNGSIGYLDKPFACHPTNGVWEVSYLPTTKYPLSEFNLKFAAWFVVVLKTGGLELFRWEGEGRFASGFRGIYEEGDNMGGGGSSSGGSSYTLRPEYTPVKIQQHLVRRACLHGNCIGHYYPQTTMTTATATSSTPSTTSATPVKSTTEPAPIYCRRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFZ0</accession>
    <name>G0SFZ0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein DOM34 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0072650</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Dom34-Hbs1 complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:20890290). In the Dom34-Hbs1 complex, dom34 recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following ribosome-binding, the Dom34-Hbs1 complex promotes the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the eukaryotic release factor 1 family. Pelota subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697523.1">
        <property type="nucleotide sequence ID" value="XM_006697460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFZ0"/>
    <dbReference type="STRING" id="759272.G0SFZ0"/>
    <dbReference type="GeneID" id="18261303"/>
    <dbReference type="KEGG" id="cthr:CTHT_0072650"/>
    <dbReference type="eggNOG" id="KOG2869">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023334_3_1_1"/>
    <dbReference type="OMA" id="DDLWHLK"/>
    <dbReference type="OrthoDB" id="10249111at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071025">
        <property type="term" value="P:RNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000008">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.870">
        <property type="entry name" value="Pelota, domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038069">
        <property type="entry name" value="Pelota/DOM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058547">
        <property type="entry name" value="Pelota_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004405">
        <property type="entry name" value="TF_pelota"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00111">
        <property type="entry name" value="pelota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853">
        <property type="entry name" value="PELOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853:SF0">
        <property type="entry name" value="PROTEIN PELOTA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26356">
        <property type="entry name" value="Pelota_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159065">
        <property type="entry name" value="Dom34/Pelota N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="8">
        <location>
            <begin position="6"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="394"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS17905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="421" mass="47229" checksum="9A7428EFDB7CC0A3" modified="2011-10-19" version="1">MRFANKRQTVSGLEAEEGVKLLIDDPEDLWHAHNLINEGDLVDAPTLRTSRVEAPSTHNVVYKTEYLNLTVKVKSVFYDPAVSELKVSGFIARDAEGTVLGQHHTLTIKWENRKDRQLYFTLWKEDGWDTVAREALSEALNPDRPESMIAIVMQEGLSNICLVTGHRTILRQRVNTGRARKADELMNKKVRNKVQSFYEQTLLALRASADLSMPRTLILASPGFVAHSFREYLAQAAIKQEDKVLQKMANEAIIVHTSTGQVHNLNEVLMSPEVEKTVRNCKFAAASSIMDRFYEMMRKEDGRAWYGFNTVSKAVSEGAVGRGGGILLMNIALFRAVDLPTRKKYVALVDKVKADGGEVRLLSNEHESGQRLDALGGVAAILTYPMFELDLEENEEEKTKAHDGKPNTEEWEESAEGTTII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0SG21</accession>
    <name>G0SG21_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative sulfate transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0064740</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696778.1">
        <property type="nucleotide sequence ID" value="XM_006696715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SG21"/>
    <dbReference type="STRING" id="759272.G0SG21"/>
    <dbReference type="GeneID" id="18260512"/>
    <dbReference type="KEGG" id="cthr:CTHT_0064740"/>
    <dbReference type="eggNOG" id="KOG0236">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003182_10_0_1"/>
    <dbReference type="OMA" id="TGPMSVT"/>
    <dbReference type="OrthoDB" id="427213at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="531"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="588"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="74"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS17160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="730" mass="79726" checksum="BCBAC620AAA1F797" modified="2011-10-19" version="1">MTSNSNSSSGRDHAPLHPSHLRQAFTPSSYGSTDDSSSTRSAPSLHSRAGPSTERPTEATALLESALNFREPPHEGPCYHGVFSPRPTSPVNSVQGDLSTPSGDEEPDGTMTLGQRKTKSWRTKIAAKIKSKKISSSRRLAQRYGVEDSAWMYLSYYMPVLNWAREYSWSYFKGDFVAALTVAGMYVPMALSLADNLAHVPPINGLYSFVFNPLIYALLGSSPSMIVGPEAAGSLLVGTVIKGAVDRNGGDHDAMLHAKLCGIVSGIAGAMVFIAGLARLGFLDSVLSRPFLRGFISAIGIVIAVDQLIPELGLSILADQEHVGHSSSVDKVTFIFRNLHNVHTLSFAVAATSFVVIMVCREIKRRLQPRYPGVAYIPDRFLVVVLSAFLAYQFKWDTAGVAVLGKVEAASGHVFKFRWPLQPANLQYIRDSMSTSFLIALLGFFESSVAAKSLGGEGFAGIQLSPNRELVALGAANLVGGCFASLPAFGGYGRSKKPVLSSLISVVAWSLIEECPYDIHFFLKIRAWKELGLMAIILLTTIFFSLTAGMAIGVGLSLLQVIRHATRPRIQILGRIPGTDRFENAEANPDRLEFIEGCLIVKIPEPLTFANTGELKTRLRRLERYGTSLAHPALPRLRREDWNRNIIFDIHGVTSLDGSGVQVLEEIVRGYRERRVRVIFSRGPGPDSKVGRLLRRSGIVELVGEHHFVNDVHEALKLTEAEEMGRADRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGB5</accession>
    <name>G0SGB5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Elongation factor Tu</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0065730</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696872.1">
        <property type="nucleotide sequence ID" value="XM_006696809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGB5"/>
    <dbReference type="STRING" id="759272.G0SGB5"/>
    <dbReference type="GeneID" id="18260611"/>
    <dbReference type="KEGG" id="cthr:CTHT_0065730"/>
    <dbReference type="eggNOG" id="KOG0460">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007265_0_1_1"/>
    <dbReference type="OMA" id="EGDKEWG"/>
    <dbReference type="OrthoDB" id="2067at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03707">
        <property type="entry name" value="EFTU_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000001">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000003">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000766">
        <property type="entry name" value="PRK00049.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009372">
        <property type="entry name" value="PRK12735.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009373">
        <property type="entry name" value="PRK12736.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF36">
        <property type="entry name" value="ELONGATION FACTOR TU, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="52"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS17254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="444" mass="49184" checksum="46EE9407776039B0" modified="2011-10-19" version="1">MSAISRTFAPFLRTARLSLFRQAQNPLVQLQRESRTPILNFARTYAVYTRDKPHVNIGTIGHVDHGKTTLSAAITKRQAEKGLANFLDYGAIDKAPEERKRGITISTAHIEYSTENRHYSHVDCPGHADYIKNMITGAAAMDGAIIVVAASDGQMPQTREHMLLARQVGVQRLVVFVNKVDALEDPEMLELVEMEMRELLNQYGFDGENTPVIMGSALCALEGKRPEIGAEKIDELLKAVDEWIPTPQRSVDKPFLMSIEDVFSIGGRGTVVSGRVERGILKKDSDVEIVGKRNEVIKTKVTDIETFKKSCEEAIAGDNSGLLLRGVRREDVKRGMVVAAPGSVSAHKKFLLSMYVLTKEEGGRHTGFQQNYRPQVFIRSADEACTLTWPEGTEDPHSKMVMPGDNVEMVAEIHHPIAMEPGLRVTIREGGRTVATGLITRILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGC5</accession>
    <name>G0SGC5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0065830</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696882.1">
        <property type="nucleotide sequence ID" value="XM_006696819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGC5"/>
    <dbReference type="STRING" id="759272.G0SGC5"/>
    <dbReference type="GeneID" id="18260621"/>
    <dbReference type="KEGG" id="cthr:CTHT_0065830"/>
    <dbReference type="eggNOG" id="ENOG502S4R7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030267_1_0_1"/>
    <dbReference type="OMA" id="AHEDWDY"/>
    <dbReference type="OrthoDB" id="2157498at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029164">
        <property type="entry name" value="PIG-Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39400:SF1">
        <property type="entry name" value="PIG-P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39400">
        <property type="entry name" value="YALI0E29227P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15159">
        <property type="entry name" value="PIG-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="410"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="455"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="492" mass="52733" checksum="8086D0CF08ADAB8E" modified="2011-10-19" version="1">METTTTDPSPVQSSQSRQPSSNPDAQQQPVSGRQPAPARKRSSSGAGGLLSKLPFIRSSGEHRPRSRRNTNESDLTPAAQTQFPPIPSFTTLPADRSPRHTSAAIPSSTVTQPPTPHLLPLSALQLPLKQRRRRGSLRKAALLGRGVQRARREARDLTIDTKIQITGDGMPIEIHVGSVPSKAPDATSSNNNSPHRSIPVVKTEDHDSPSLGLGISEFTPRPGVDGYSSLRSSTPTSDPDMTPIAATAPNPHTSTPNITTTSYTIPGSSSPTIGYSTTDDEDSLHIQRPRSIPLPSITRQTTPSLSSASTTSLLLRPERASVSSISGSESYFRHRPLGTSSPAPGSPNPANGSGAAGAGTATTNMLTPSLDVRRRQKQRAKSPLALMSTASGLPPQDVGWDYSETEWWGWIILIVTWTVFVIGMGSCLGVWSWAWDVGTTPYAPPELEDDPTLPIVGYYPALMILTGVMAWVWVVVAWVGMKYFRHAQVSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGG1</accession>
    <name>G0SGG1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metalloendopeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0066210</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696918.1">
        <property type="nucleotide sequence ID" value="XM_006696855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGG1"/>
    <dbReference type="STRING" id="759272.G0SGG1"/>
    <dbReference type="MEROPS" id="M16.A04"/>
    <dbReference type="GeneID" id="18260659"/>
    <dbReference type="KEGG" id="cthr:CTHT_0066210"/>
    <dbReference type="eggNOG" id="KOG0961">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006065_0_0_1"/>
    <dbReference type="OMA" id="WEGFARI"/>
    <dbReference type="OrthoDB" id="4953at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000015">
        <property type="entry name" value="Putative zinc metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000031">
        <property type="entry name" value="Putative zinc metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000036">
        <property type="entry name" value="Putative zinc metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000042">
        <property type="entry name" value="Zinc metalloprotease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF16">
        <property type="entry name" value="METALLOPROTEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07610)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="2">
        <location>
            <begin position="59"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="3">
        <location>
            <begin position="197"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1038"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS17300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1051" mass="118816" checksum="07419EB748EFE12A" modified="2011-10-19" version="1">MTQLQRPRFRKVQSFRTNYAPATITQYVSERSGMQVIVADRKGPKISGYFTLATEIFDDSGAPHTLEHLVFMGSKRYQYRGLLEKLANRAYSYTNAWTAVDHTAYTLETAGWDGFAQILPVYLEHIIVPHITDDSCITEVHHIDGEGNDAGVVYSEMQALQYRSIELMDLKARRLLYPENVGFRYETGGMMEALRVLTPERIREFHKSMYHPQNMAIIVIGEANHDDLLRILDEFEERIAEDIPPPDPQFKRPFVDSPQPPPLEKTFVETVEFPEEDESTGEIAVAFFGPSCTDQVQATAMNIVMTYLCGSSVSVLENILVEKEQLASSVTYLLESRPNILVWFQPTGVSTEKLEFVYKRLIELLKEVASKPLDMDYMKECIQREKRQVKLHAEGSEQFYANNIITDYLFGDRDGRTLKDLETLVEYDVLESWTDGQWREFLRKWLSDAHHVSILGKPSKKFADELKAREAERLAKRKEELGKEGLERLRQRLETAKKNNEEPIPPEVLDQWPVPGTSSIHFIESETARAGKARTLGVFDNAPQKIIDSAAQSRPLFVQFESVPSNFVHLTVHVGMSKTPAKYKPLLPLFNDIFFNSPVMRDGKRIEFEEVVKQLEKDSISYEISSAARLGDSEGVSIQFQLEWEKYSIIISWLRTLMFDIIFDPVRLKAAIVKALADIPEEKRDGRAMAQEVSVAIHMKPESYLTAKRTLVKAVYLRRLKKLLEKEPETVVSWFNELRQSLFQFENIRVLVTADVAKLDNPVAPWDVLFQEPGLDHTKDLQPITKLHQLLSPEGESPGSYGSVIIPMTTLDSSYSVSFARGLKSHSDPRLPAYLVALGYLEAVGGPLWNAVRGTGLAYGVGFSREVDGGYIQFRVYRSPDASKAIEASRKIVAKIASGETPLDRHLVEGAVSGVVLGVADEQATMAAAAQYNYISTVVRGLEPGWNKKILAKVREVTDDEIREVMREIIMPVFEPGKSNVIVTCAPIMEENIVKALSAVGYKTQVHQLSDFYDDYGLKADEDGEEDSEEEEDEEMEDGSSYTSGSDEDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGI3</accession>
    <name>G0SGI3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0066430</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696940.1">
        <property type="nucleotide sequence ID" value="XM_006696877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGI3"/>
    <dbReference type="STRING" id="759272.G0SGI3"/>
    <dbReference type="GeneID" id="18260681"/>
    <dbReference type="KEGG" id="cthr:CTHT_0066430"/>
    <dbReference type="eggNOG" id="ENOG502SHIF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037656_0_0_1"/>
    <dbReference type="OMA" id="RCACVGF"/>
    <dbReference type="OrthoDB" id="4187949at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="581" mass="64514" checksum="6D1143C5FD84D65E" modified="2011-10-19" version="1">MTDQRSASPSPLQMAAKNREGEARLPKGHCRYILLLPEIKGQRCACVAFSLNKEIPSATCDCGHLACYHTNDPEPSTDQRQELEALKQKVYQLEAALSRGHDDVVDRFASRFAEVEDHVERHKEEVGESVKNVYRNVCLNWDTIQQTNRRLQQQEEQIREMQSKLKQHAEQIDELHASQLELRDADISLEERIENLTELMEEQEEMRQSSSRPSRRRSTSDASHPNVPLTPLGQGAAPSSDSSQRPSRSPAGGPVNPSPSRSGHGEGTGREGSRPPMTSLTTMVTRPIRLIPPLSARSTEAWTVHISLLPHASLPMPFERNTNAYQRCLSRGLHQMVAVQGRDWPAFKTAVEKAFGRFLRGREWMPLQAKLCDAETLQGLPMLRQLDPRLIDFERGYDHAFLRRHCAVCDSNGMIDSLYIAMRYHTISWHTLRHSPVYLDGLEGCWKYDHLLDSGDPFPDSDDAIDDQARPAAGDITTVLPNVRSQVTATGVKRPLSEMSRSASFGSATAVQPGPMVVGSSPSSSSSSSATAVPELHEDQPRAAKRMCPAVPIPVTVPVPVSVSSAASPIVEVRRRDIKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGI6</accession>
    <name>G0SGI6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0066460</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696943.1">
        <property type="nucleotide sequence ID" value="XM_006696880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGI6"/>
    <dbReference type="GeneID" id="18260684"/>
    <dbReference type="KEGG" id="cthr:CTHT_0066460"/>
    <dbReference type="HOGENOM" id="CLU_723614_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="382" mass="44702" checksum="E454D73A9107B058" modified="2011-10-19" version="1">MLLRRLAGRALRQPLAPFGQPPSWLFSRQLPMAERSSPSFALTRHLPISYPDSLCRNYSSRKSKKKKQKQQQKDKLSPYQRRKLKERKYIEHLLSSTSSKPGDSAPGAGLSAFFNDTMYSMGHSEDVENNLPSSKDIESVEFDWEGIEQSDVEDEEFGGLKFTKRQQPISKDKGSANFNLVEDQKPSLEDTKPIELDSKVAEKEDETCVFPSQQKTRKKVKLTDTLIEPELDPDSPVDPEKFTTPLDIDLSPDPRPRKGQQPLDPEEEKRRLLEYLEKPWEPWRPPEKQENRLNHHERRRIKRRLEMAARKKLQLQKKYGIEPGSTERDERVDLELAMWLVMEDQKDTERRMKKWERTAKKREKLKKKGMFKKARYAPSLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2023-02-22" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGP1</accession>
    <name>G0SGP1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0067050</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696998.1">
        <property type="nucleotide sequence ID" value="XM_006696935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGP1"/>
    <dbReference type="GeneID" id="18260743"/>
    <dbReference type="KEGG" id="cthr:CTHT_0067050"/>
    <dbReference type="HOGENOM" id="CLU_909126_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS17380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="306" mass="34853" checksum="F19D096B461B53AC" modified="2011-10-19" version="1">MAANNPVKGDKGEGKDRKDGELYGPLWKGSPYWTRIRALENIDLLAYFGANRILALIGGRTIHVTFLLYRLRHVLPTVTIQDPQAEHTGIDYLCEPFSLSTDHTELNLRAHWSNLCKHLAQLEQEYGRLLVKLLTDLRKFATHFQHLQHAGDNNGMDEPNQTFAFVLIIEELLSAGWEGAIARDTLQAIQVGVECTKEEIDQMLGVMEGTREYLQSGIIMGVRVNEAEGVDVSNLCELLEMERVGMDEEIIHQGIVKIRQQMQPFKELREAAECVERSLKAAWEFCERHVWFKDGDAAWLVIGFKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGV3</accession>
    <name>G0SGV3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0067690</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697060.1">
        <property type="nucleotide sequence ID" value="XM_006696997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGV3"/>
    <dbReference type="STRING" id="759272.G0SGV3"/>
    <dbReference type="GeneID" id="18260807"/>
    <dbReference type="KEGG" id="cthr:CTHT_0067690"/>
    <dbReference type="eggNOG" id="KOG2627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024820_0_0_1"/>
    <dbReference type="OMA" id="AQNDYLD"/>
    <dbReference type="OrthoDB" id="19679at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019148">
        <property type="entry name" value="Nuclear_protein_DGCR14_ESS-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940">
        <property type="entry name" value="ES-2 PROTEIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940:SF0">
        <property type="entry name" value="SPLICING FACTOR ESS-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09751">
        <property type="entry name" value="Es2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="256"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="406"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS17442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="479" mass="51915" checksum="1409754897C765A8" modified="2011-10-19" version="1">MTDKALIRKRSDTELMPPPPPAKRIARPKHVLDEDTYTEALSHIIARDFFPGLLEIETQKEYLDALESKDEEWIESAARRLKSVMTPGRRRDLLATPLRNGLQGAAGRTPVGFVGDTPASMASNATAATAAKPAVDTSLSLAAFQAKYTSEDNESFYKLLDKQNQKKAEKYAWLWTGNKLPSKQQLKQKEVEAKLLAQRGSLVDDGFKRDRLAIRDSADVPDRPAAPDTWKIDNPRNQLMFVPDGIEERGLQTVAERQAAESRAPPKKIVYANTRAPLPPTATIKDANSGSTSDNRSTRAGSPSLSEIRLAIAGHRRPCDAESSIAPSTTAGGETPRVNGYAFVSDRSPSPEPRASKKKKKDPLPEIELGPGDPTPNPFSLQPVRKREELHHRMVEKIAASRREASRLGVTGKVSGVGTPATVRSMTPGGRMAAGNLTPAAQRLLGKVVGSTFGGGVSPFSERVVATPRTVKRAGGSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGX5</accession>
    <name>G0SGX5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein CASP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0067910</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CASP family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697082.1">
        <property type="nucleotide sequence ID" value="XM_006697019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGX5"/>
    <dbReference type="STRING" id="759272.G0SGX5"/>
    <dbReference type="GeneID" id="18260829"/>
    <dbReference type="KEGG" id="cthr:CTHT_0067910"/>
    <dbReference type="eggNOG" id="KOG0963">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016758_1_0_1"/>
    <dbReference type="OMA" id="WQQEGFN"/>
    <dbReference type="OrthoDB" id="10257567at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012955">
        <property type="entry name" value="CASP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057476">
        <property type="entry name" value="Cux_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043">
        <property type="entry name" value="CCAAT DISPLACEMENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043:SF2">
        <property type="entry name" value="HOMEOBOX PROTEIN CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08172">
        <property type="entry name" value="CASP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25398">
        <property type="entry name" value="CUX1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="673"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="Cux N-terminal" evidence="14">
        <location>
            <begin position="17"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="CASP C-terminal" evidence="13">
        <location>
            <begin position="426"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="480"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="595"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="249"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="411"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="526"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="595"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS17464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="735" mass="81754" checksum="126C4D1293A6463D" modified="2011-10-19" version="1">MGEGSVADTVPPAPPSTANKFQNAISQWRTVDFTNLISNLDNTASEIVAFQRDSTVQRKDLAQKTKDFRKLDDASKLAEIKGLLKAYQTFIDLLTNHSKSVNSAFLHAYTALSEAPDPYPLLEASVDSMLVSEDTLPKLTEENQHLQKTVSRLTSQLEETESRLQAERDTRKKLEETLESKVREVESSWTAVLEEKKDNWEAKERALEEKIENQERLLNEIKASYEVNQRLGKADDAENQQGHVTSAELEMVNADLERTTARLAEVEARNEQLRLELAQAKSQASSQTVTSLEDDPAYMRMQSENSSLIRKLEAVRVEKEGLKRDLDTKLRGLEREVVLLKEERDALKAKVQKWSDYDEVKQELEVLKSIEFSTGDDDDAVADENSSKLSSKGDNLEQLLLARNKKLSDELTILRVSHQDLQGKLQKLQDELSRTNAELEKSQSLNEKLENELSTIQAEATNAFPSGASVAGTAYRYAPSVAPSRRPGGRTSPTSSIISGFNPRDPSDDRASTPGSGILPMITAQRDRFKKRNAELETELKEAHRTISQLRQEVAALQRDNLNLYEKTRYIASYNRATTSSAMTSSSSAFAVGSSSAATNPNPSTIPISPSTSPSPPTLDRYRKAYESNLSHLSPFAAFRGRESARAYQRMSLPERVVYSLSRAVLSTRTRRNLFACYVVLLHLLVFYTLFWMGGCEVDRFVEVGGAVVGTAAGAGGDAGVVGEGRDWREGQVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G0SH60</accession>
    <name>G0SH60_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">26S proteasome regulatory subunit 4 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0068820</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697167.1">
        <property type="nucleotide sequence ID" value="XM_006697104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SH60"/>
    <dbReference type="STRING" id="759272.G0SH60"/>
    <dbReference type="GeneID" id="18260920"/>
    <dbReference type="KEGG" id="cthr:CTHT_0068820"/>
    <dbReference type="eggNOG" id="KOG0726">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_2_3_1"/>
    <dbReference type="OMA" id="QDDTDPM"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000007">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000039">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="237"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="92"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS17549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="459" mass="50966" checksum="45708560A69606DE" modified="2011-10-19" version="1">MGQSQSGMGGGHDGRDEKDKKKEKPKYEPPPRPTTRVGRKKKKQGGASAASKLPPVFPTSRCKLRLLRMQRIHDHLLLEEEYVENQERLRKAKAAKDSSGSSSELDTVDRLADERSRVDDMRGSPMGVGTLEEMIDDDHAIVSSATGPEYYVSIMSFVDKDLLEPGASVLLHHKTVSIVGVLTDDTDPLVSVMKLEKAPTESYADIGGLEQQIQEVRESVELPLLHPELYEEMGIKPPKGVILYGAPGTGKTLLAKAVANQTSATFLRIVGSELIQKYLGDGPRLVRQLFQVAAENAPSIVFIDEIDAIGTKRYDSTSGGEREVQRTMLELLNQLDGFDDRGDVKVIMATNKIESLDPALIRPGRIDRKILFENPDQNTKRKIFALHTSKMSLAEDVDLEEFIAQKDDLSGADIKAICTEAGLMALRERRMRVQMSDFRAARERVLRTKQEGEPEGLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHI3</accession>
    <name>G0SHI3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0070120</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697290.1">
        <property type="nucleotide sequence ID" value="XM_006697227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHI3"/>
    <dbReference type="GeneID" id="18261050"/>
    <dbReference type="KEGG" id="cthr:CTHT_0070120"/>
    <dbReference type="eggNOG" id="ENOG502QQUZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009044_0_0_1"/>
    <dbReference type="OMA" id="GRHFWAQ"/>
    <dbReference type="OrthoDB" id="66409at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052809">
        <property type="entry name" value="Actin_polarity_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012860">
        <property type="entry name" value="Afi1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28245">
        <property type="entry name" value="ARF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28245:SF1">
        <property type="entry name" value="ARF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07792">
        <property type="entry name" value="Afi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08616">
        <property type="entry name" value="SPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="2">
        <location>
            <begin position="71"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="768" mass="86461" checksum="4D35A5BFCC73D420" modified="2011-10-19" version="1">MSQIARPTAMASDPDLSDTNAKSKTPSTASSSHQNNTLSVASRRGRYDASGRKRKKLRSQYPRGSTENHVEYILVASFDIDRGPVMEHQYPVAITGDEHMLAELMLPDQAHVRNQDWTIFFLHKDPSQEEEEAERRAREERRARRARRRDRAKGIIHESDDEADGTGLDDDDWDDDSSDSEPEINEGPPLIYVLNLVNTKQDKTVKRGAIPLLLLALEEYFKAPVPETLAMLYNAVNEMDLSLMPKLSYLERHLLQVSDNKDLFVEKFEQMIQERIAEEQGEDLADQPLDASREPPKRPSIFRSGTKQHIEGHSAYAVPRDTHEFESKVVYKGIPIPIKVPVAVMPETVGDFSLIKLIQNFSEPHAKNPQTFPLHPHLTTNGPNTHPIIVLVNALLTEKRIIFLGHNMPSGEVAEAVLAACALASGGILRGFTRHAFPYTDLTKIDDLLKVPGFIAGVTNPTFEHHPEWWDLLCDLPSGKIKISSKIEAAPITEGLVYFQQQNPAYANLVGGGAAANNDLTGDAAFMADILRSIASRAGERVIRAKWRGWIQKFTRIAAAFEESVFGTSALHITSDDPEAATLAQYGHGYVWADEATKVRELAGNVTRIEAWRNTRSYYSYIQDVAQSYTLRPLKGLDLAHLHDRLRTQRLTPQQSREIYDALCKYVRSYDEICLLLSVAPESQAGLFYVALGLFHKDRDVRFRTADLLERIAEHEAGQHWWRALSRFEKLAYMRIKREAEAEARAKAMQEREGGFGIGSPTDNRRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHT8</accession>
    <name>G0SHT8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative RNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0073330</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697590.1">
        <property type="nucleotide sequence ID" value="XM_006697527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHT8"/>
    <dbReference type="STRING" id="759272.G0SHT8"/>
    <dbReference type="GeneID" id="18261371"/>
    <dbReference type="KEGG" id="cthr:CTHT_0073330"/>
    <dbReference type="eggNOG" id="KOG0130">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_18_0_1"/>
    <dbReference type="OMA" id="ESEMQTH"/>
    <dbReference type="OrthoDB" id="15688at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12324">
        <property type="entry name" value="RRM_RBM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008111">
        <property type="entry name" value="RNA-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033744">
        <property type="entry name" value="RRM_RBM8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45894">
        <property type="entry name" value="RNA-BINDING PROTEIN 8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01738">
        <property type="entry name" value="RNABINDINGM8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="54"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="132"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS17008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="174" mass="18725" checksum="3CDFAC7D116A1F95" modified="2011-10-19" version="1">MPTDRDEMDLDEPVQPSSSDKNDKSKTPADVSSAKLAMMQTHNKATAVRSIEGWIIMVTNVHEEADEEAIQDKFGEFGEIRNIHLNLDRRTGYVKGYALIEYATLEEARAAIDGAHNTQLLDQTIQVDFAFVRPPPGKAAGGPRSGGGGASSGRGAGRGGRSGRSRSRSPGRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0SI23</accession>
    <name>G0SI23_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0074220</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697675.1">
        <property type="nucleotide sequence ID" value="XM_006697612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SI23"/>
    <dbReference type="STRING" id="759272.G0SI23"/>
    <dbReference type="GeneID" id="18261460"/>
    <dbReference type="KEGG" id="cthr:CTHT_0074220"/>
    <dbReference type="eggNOG" id="ENOG502S41G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038171_0_0_1"/>
    <dbReference type="OMA" id="IASVYTN"/>
    <dbReference type="OrthoDB" id="2020070at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055100">
        <property type="entry name" value="GNAT_LYC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053013">
        <property type="entry name" value="LAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815">
        <property type="entry name" value="LYSINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815:SF4">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22998">
        <property type="entry name" value="GNAT_LYC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="112"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="LYC1 C-terminal" evidence="2">
        <location>
            <begin position="186"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="42620" checksum="02BC62E3CA327DB3" modified="2011-10-19" version="1">MSPSSDQPQETTLPPIEPINPSLVTFTIATPHQRILSWRLNGASWASPLTLDQYVGREQTLSETELSANGGTLYYILHHRDDPELIISACEVTSKRLVIAGPGTNGSKVGNGYAIASVFTNPRFRNQGMASYLLKRVQEEVDKRGDECGVLYSDIGRVFYTRLGWKDFRTPQLLAGIEGDATAFPVPEGVELLNEDQVRKLCEDDVKAVEEEFSRLAAAPDGKTHIVFLPTPAQFSWHFARDGYVCPILRNREVQWRGARTEDGLAWIAWDHDLREKKLKILRIVSRHSAEEKKKAVKRLLLAAMAEARDWDVPKVLVWEPSEEVSVAATEIWRELGPKVSLVFEEREDGSIPSLRWQNGENREVVWHHNEYYGWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>G0SI33</accession>
    <name>G0SI33_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0074320</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697685.1">
        <property type="nucleotide sequence ID" value="XM_006697622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SI33"/>
    <dbReference type="GeneID" id="18261470"/>
    <dbReference type="KEGG" id="cthr:CTHT_0074320"/>
    <dbReference type="HOGENOM" id="CLU_1875205_0_0_1"/>
    <dbReference type="OrthoDB" id="6220758at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="136" mass="14468" checksum="C6DDC2EB5E22C6CC" modified="2011-10-19" version="1">MSNPGPMPPTASASTTSPLPPEAQHFGAEIKGNPTESEADVAADRSDLDPLPDYVRRQMKKAMREGGGEAGFPPAAPTPTPEEFGSTTSWESADQWFGEGVVKGNPTTSEADVAADRSRVDPLRRKLRFRKTIGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0RY78</accession>
    <name>G0RY78_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Diadenosine and diphosphoinositol polyphosphate phosphohydrolase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0005720</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691106.1">
        <property type="nucleotide sequence ID" value="XM_006691043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RY78"/>
    <dbReference type="STRING" id="759272.G0RY78"/>
    <dbReference type="GeneID" id="18254610"/>
    <dbReference type="KEGG" id="cthr:CTHT_0005720"/>
    <dbReference type="eggNOG" id="KOG2839">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_5_3_1"/>
    <dbReference type="OMA" id="ESDESCQ"/>
    <dbReference type="OrthoDB" id="2011998at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034431">
        <property type="term" value="F:bis(5'-adenosyl)-hexaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034432">
        <property type="term" value="F:bis(5'-adenosyl)-pentaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008486">
        <property type="term" value="F:diphosphoinositol-polyphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901911">
        <property type="term" value="P:adenosine 5'-(hexahydrogen pentaphosphate) catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901909">
        <property type="term" value="P:diadenosine hexaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901907">
        <property type="term" value="P:diadenosine pentaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071543">
        <property type="term" value="P:diphosphoinositol polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04666">
        <property type="entry name" value="NUDIX_DIPP2_like_Nudt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047198">
        <property type="entry name" value="DDP-like_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629">
        <property type="entry name" value="DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629:SF0">
        <property type="entry name" value="DIPHOSPHOINOSITOL-POLYPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
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    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="32"/>
            <end position="176"/>
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            <begin position="1"/>
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            <begin position="1"/>
            <end position="14"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGS23864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="182" mass="20913" checksum="809610487A3E8C33" modified="2011-10-19" version="1">MSPAGTVTTSSGVTRSMESRTGRSNQRYNTKGERLVAGVVPLTEDKSYVMLIQSTRRKGWVLPKGGWETDEECHEAAAREAWEEAGILVEIVYDLGEIRETSPRKKSSQTNSSGSPTKDGKKEKERSLYHFYEVTVTSEEADWPEREKRERKWFTFVEAHELLKDRPELQTALERSRMRRSL</sequence>
</entry>
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        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Signal recognition particle SEC65 subunit"/>
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    </dbReference>
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        <property type="entry name" value="SRP19-like_sf"/>
    </dbReference>
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        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 19 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="72"/>
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    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGS23976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="296" mass="31508" checksum="7749434E69E2F578" modified="2011-10-19" version="1">MSHPRVEEVSDSDLEMSDPSEADIDDFVESDILRARNQQQSSSSSSRPSQNPPKPAPSSQKQPHFPRPYPAMATTTDESAYKRFQCLYPVYFDATRSRAEGRRVPAHLAVKNPLATEIVAACANLRLTTVLEVGKQHPKDWANPGRVKVDLASLPPNAPVKIKNKHHLYLLVAQHLRENPTSDTSPALHVVVRGAPPPPPGVVEPGKPWPRPAVPRGWKMGELLPYYSPAMTGGGVSENFLKDMMKEMQNAGAGGGFPGLGGDMASLLGAMGGGLGGMGVAPAAGGSSGGKKKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYL7</accession>
    <name>G0RYL7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy-related protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CTHT_0007140</name>
    </gene>
    <organism evidence="23">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
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            <topology evidence="4">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
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            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Preautophagosomal structure membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATG27 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006691182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYL7"/>
    <dbReference type="STRING" id="759272.G0RYL7"/>
    <dbReference type="GeneID" id="18254752"/>
    <dbReference type="KEGG" id="cthr:CTHT_0007140"/>
    <dbReference type="eggNOG" id="ENOG502QVJJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OMA" id="AFDCKDI"/>
    <dbReference type="OrthoDB" id="29460at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018939">
        <property type="entry name" value="Autophagy-rel_prot_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF13">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09451">
        <property type="entry name" value="ATG27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0072">Autophagy</keyword>
    <keyword evidence="17" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 20" id="KW-0732">Signal</keyword>
    <keyword evidence="8 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409142" description="Autophagy-related protein 27" evidence="20">
        <location>
            <begin position="30"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="21">
        <location>
            <begin position="38"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="197"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005363"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EGS24003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="358" mass="40168" checksum="0E8D1EFC2AE59343" modified="2011-10-19" version="1">MTRPSRPTQTAGPLLLLLLLGSTASPSSAAATAPPSTFDCAKVEFDGHTYDFHDLAGPHTIVTTEYAAPTYRNTTYTIDLCGPLKRKGDIAKEERCPDVCAIKHRFDPKTGKSVTDSVIPIVIGHGNDHAAFNWGIKRIAEGRDTKDKKNDGLRLTLQSDTTYQQRPQSAVISLRCDPEKVGTEGEWEQKLVEYEPAKKNSKRGVETQEDTKKEEKDPVDISQPEHQLRKQDAALLWEGYKREQVVDGTETKEIDTLYLTWYTKHACRAEGENPPTDGGKESKHWGFFTWVFIIAFLAVASYLIFGSWLNYHRYGARGWDLLPHSDLIRDIPYLLRDVIRRVLNTVQSSGSRGGYSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYN2</accession>
    <name>G0RYN2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nuclease-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0007290</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2015" name="Cell Rep." volume="13" first="2565" last="2575">
            <title>Crystal Structure of a Eukaryotic GEN1 Resolving Enzyme Bound to DNA.</title>
            <authorList>
                <person name="Liu Y."/>
                <person name="Freeman A.D.J."/>
                <person name="Declais A.C."/>
                <person name="Wilson T.J."/>
                <person name="Gartner A."/>
                <person name="Lilley D.M.J."/>
            </authorList>
            <dbReference type="PubMed" id="26686639"/>
            <dbReference type="DOI" id="10.1016/j.celrep.2015.11.042"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 2-465 IN COMPLEX WITH MG(2+) AND MN(2+)</scope>
        <scope>DISULFIDE BONDS</scope>
    </reference>
    <reference evidence="10 11 12" key="3">
        <citation type="journal article" date="2018" name="Nucleic Acids Res." volume="46" first="11089" last="11098">
            <title>A monovalent ion in the DNA binding interface of the eukaryotic junction-resolving enzyme GEN1.</title>
            <authorList>
                <person name="Liu Y."/>
                <person name="Freeman A.D."/>
                <person name="Declais A.C."/>
                <person name="Lilley D.M.J."/>
            </authorList>
            <dbReference type="PubMed" id="30247722"/>
            <dbReference type="DOI" id="10.1093/nar/gky863"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 1-530 IN COMPLEX WITH MG(2+)</scope>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS24018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691260.1">
        <property type="nucleotide sequence ID" value="XM_006691197.1"/>
    </dbReference>
    <dbReference type="PDB" id="5CNQ">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.60 A"/>
        <property type="chains" value="A=2-465"/>
    </dbReference>
    <dbReference type="PDB" id="5CO8">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.40 A"/>
        <property type="chains" value="A/C=2-465"/>
    </dbReference>
    <dbReference type="PDB" id="6GRB">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.40 A"/>
        <property type="chains" value="A=1-530"/>
    </dbReference>
    <dbReference type="PDB" id="6GRC">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.45 A"/>
        <property type="chains" value="A=1-530"/>
    </dbReference>
    <dbReference type="PDB" id="6GRD">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.66 A"/>
        <property type="chains" value="A=1-530"/>
    </dbReference>
    <dbReference type="PDBsum" id="5CNQ"/>
    <dbReference type="PDBsum" id="5CO8"/>
    <dbReference type="PDBsum" id="6GRB"/>
    <dbReference type="PDBsum" id="6GRC"/>
    <dbReference type="PDBsum" id="6GRD"/>
    <dbReference type="AlphaFoldDB" id="G0RYN2"/>
    <dbReference type="SMR" id="G0RYN2"/>
    <dbReference type="STRING" id="759272.G0RYN2"/>
    <dbReference type="GeneID" id="18254767"/>
    <dbReference type="KEGG" id="cthr:CTHT_0007290"/>
    <dbReference type="eggNOG" id="KOG2519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007575_0_0_1"/>
    <dbReference type="OMA" id="DGNHAMV"/>
    <dbReference type="OrthoDB" id="2959108at2759"/>
    <dbReference type="BRENDA" id="3.1.21.10">
        <property type="organism ID" value="1279"/>
    </dbReference>
    <dbReference type="EvolutionaryTrace" id="G0RYN2"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09906">
        <property type="entry name" value="H3TH_YEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09870">
        <property type="entry name" value="PIN_YEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000037">
        <property type="entry name" value="Rad2-like endonuclease, putative (AFU_orthologue AFUA_3G13260)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000051">
        <property type="entry name" value="Rad2-like endonuclease, putative (AFU_orthologue AFUA_3G13260)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041177">
        <property type="entry name" value="GEN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037316">
        <property type="entry name" value="Yen1_H3TH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF75">
        <property type="entry name" value="ENDONUCLEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18380">
        <property type="entry name" value="GEN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8 9 10" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="4">
        <location>
            <begin position="108"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="459"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="507"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="461"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="521"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="546"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="564"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="644"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="674"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="699"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="731"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="744"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="763"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="786"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="816"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="829"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9 10 11">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10 11">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10 11">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Interchain" evidence="9">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS24018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="5CNQ"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="5CO8"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="6GRB"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="6GRC"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="6GRD"/>
        </source>
    </evidence>
    <sequence length="922" mass="100404" checksum="E5956606BC2625AB" modified="2011-10-19" version="1">MGIKGIYKEIGSGERISLCKLAIDHLEQHNRPLRLAIDMAIWQFQIQAARGGSNPAIRTLFYRFVRLLSLGIHPIFVFDGPNKPIFKRNRRSGTGNGVSTAMAKRLIRLFGFTAHDAPGEAEAECAYLEQQGIVDAVLSEDVDTIMFGSRVTLRDWSSEGSKGGPPTHVTLHDAKKIAEGPSGLDREGMVLVALMSGGDYLPDGIPGCGIKVACQAAKAGFGKELCRIKRADKEAITEWKQRLLHELRTNESGFFRTKHKALEIPENFPNMEVLRYYTHPVVSSPATIERLRQEFPPSSTVDIAGLREFTRETFDWTFRPGAIKLIKVLAPGLLVQRCLDRYVSGPRIDDPDLKKKEESTLVKGISMRREHFSTDATPELRVSFIPAELVGLDPGQEPEVQVEAFGRSGLALNSDDEFDEDISSSQKAPKKPFDPWQPDLAWVPETILKLGVPVTVEDWEEGQRSKGRAKEDKTAAKAKRKTKIIQSNMPAGALDKYVTVTKNISDTTVKSKESAPITIPSSPPKPSSQPAPPTLTRSKQAKKPSTKLSKQPTTRPSLDINPWTIASSQCSPPRAGPSSTLTADLLSTPTNDPPRSPAVSHVAKTMPGGSTTSSDILPSHTAAAARDVEPILIESSPVVPPPGTTASSTMANSSHPRQGTLVRGGVRGYGQKTPPKRQKRRVGQRALEEAEDSPALPTDEAKPSEVHAESQLVRKDRTFKRVKSGTEDDLSSNTASTTTQAVKQTTAPSSTSTQTSIKSFGRVSKEPIKISSEKVAAIETIVLSDSDSDSDDDDDLPLLFPTKKAPPFLRSEQNPSSSSTGSRSASSSTFVPASKSSTLVPDDDNHDEADPFGPIRPPSGDNGTQPIRSASEIPQEPGDDDTKAEKKVLGRGVWGWNAREWGKERRMWRVSEIEVVDLTGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZ06</accession>
    <name>G0RZ06_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mus7/MMS22 family-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0001230</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690676.1">
        <property type="nucleotide sequence ID" value="XM_006690613.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0RZ06"/>
    <dbReference type="GeneID" id="18254161"/>
    <dbReference type="KEGG" id="cthr:CTHT_0001230"/>
    <dbReference type="eggNOG" id="ENOG502QSDS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000374_1_0_1"/>
    <dbReference type="OMA" id="DNRIDYM"/>
    <dbReference type="OrthoDB" id="2386201at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035361">
        <property type="term" value="C:Cul8-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019021">
        <property type="entry name" value="Mms22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28122">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SUBSTRATE RECEPTOR MMS22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28122:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SUBSTRATE RECEPTOR MMS22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09462">
        <property type="entry name" value="Mus7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="799"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="957"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="709"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="970"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="983"/>
            <end position="994"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2325" mass="258752" checksum="E596610D38C4E340" modified="2011-10-19" version="1">MPNWKELGEVPDSDDDYDELPLDIDEIDCLPIIDLPVEQKDGDVPNRQDATVGQTGGGDGREEESQKQEQKVDEGTRDSRWPEKARTKQGRPQRDPYEIPSSPDEPLATRKATKIFIPLPAASQRDDGLGSVGLGSDDLAYKSQLVPSERPASSVPANTSSPPKLSTQSLPLPTQRHDGPNCPAGNDAADKTSSPARQCSDAAPSDFLQDGIFTSYVRVTTPTRPPRSASSSPLSLLAKTPSPPCASPSRQQRRPSPPAERPILQPSEDDVIRKTIVRAERSLRPRKPIQEHPYLIEKERYRKVMKSHGLKPIEVLPESPKSRKKTREEDSQEEEFRADESQESPDNGLPADETAPILFGNNILEEDELTMSSPVDRQLKTSSRQASADHTDDTSLSDEDLPPLGKIKPQKQTQRRLKRYSSGQLMSSTRKRARLVVDSSSPPPPPGRTKTAGAASRDLWDLPSSPPPVWSRPQNPLQHIADLLSSSPSRNQTGVEPQAGQLSDEDTPRHSRRGTQGAPIVIHDHDPQEDLTGSDSDSSHSSDSDSDVVRRESRRLRGLLPASWLRLDRRQNQQQEKEKQTTSRHVRRRSSELPTKRKGVALPRQASPKPPSSTAPFPIFADDDLDDASDTPPATSGSGLGTIQRPLSTAPETIVIDDEDPGSDVMEEDIIDWMPPSANRKRSGSRTLSHLAKRRKGDGLRQPKITQVLGRSTKQASSTRPKGDSTHHRVPRKKRENTPPMLSILDVVEPNAPHFIRIAARTARKKANLGKSSPSKKIICLATRSDNIVALSVLRDWKSGKTKPRVSVPSQPRKPKDRPALHEVSTNTAPRSRLFPTRKQADQATLDGFVTVRPEEGGEAVEAPRETARRLFIRKKVPNPGPIFLPAQLEEEETEDKRLSRARKRTLDAFYKRSRRVLGSAAEVLSRPLDTNFTLREESLRVGVPRPQDDAVDIVDEEDDPIPAPAPRQRQAKSRFRKRTHPHQINTDAPQYTRANDPLPVEPPPPVVLTAEVRNEPRSEDKLRGLGPYGTHYTHHFDIFPFDNDKGIFFHESTFIGQGYIRDAADPVLCEKVRRPRASVAFTLDGEVLKWGAWDDRVSSELGILVDWVGEQMGSPEELGRGVVEAAGFVVRYLTRSLSISSDADGKGVLGRCLEVFGSFVGRFEGVEWGALAEGNKRVLLDVGVRYLVAILAARTLSTADWINDFSLAMGFEEMLKKLARIVIERLLERGTDELRTLYDDLQGISVREGGIRSNRLLANWWVVLIRVLESAAIPRSSFWDLTQSVMLRDHDISHSTDAQLFERLWLDMFTLLPLTEIDNTGLHIPDQRKSLPLEGWTLPQQLLKRVLELSKANPRQPPGFNDYCRALVARCHVLVQEWGWRRCTGVIGTIFDFFGAQNLAHLRNEETNASPRFLEMLERNPVAAVRRIDPAEDRCAFHIFIKLLALAIVRLRELGGRERDIRNLVARTLPNHDRQLLKEDTVHRTDLAALRNHHDLLCALFWAAPPDSRPGIHHIEKLVVPGSAHKEACLINVRAWNQLARFVICHETGPTAPRTGVVAQLAAWRSNIFNQILDQYLSAASDIEQQFRMLSADVLLRVSEEVKEETIAKNKASAMEILHAILRASVDVLRLAPGMEEALAEFNASHVLLQKVFTTLDYEHPRFDWKIVREALDMLEHFIGRIDQAVEQQYSSNFSQNPDADRHVEEAVLLLDSRLAKEFFWMARTILKLTIEKLPREGSMQAQCAEKTVTLAGRIAARLIHHSVTKMSPYFSPGTYGLFSAPPKALTTAERTYLPLFLAVLVKNDVFDFRDLGMNILSLWLLTITKPARLLRYENYLAEALQHHHLPFLAGVTVPVTLAPDYSTNIDYLSSALHHMRKALRDAPNPGQAKVLREEFSRHLGLVMQKMREDLSLLRSLSSIEHVAYISFIRSAISLLKSLGVGICVIDPFFTQPSADYAPPMHDPTLHAAGIVAYGVRLAERDVTAAPQLFHYLFSSFRLALGNGLGMLRREEGIIARAVGEDRWVRGFILGTWVPAILGALEVRGGGLGGWVVLEVCVGALGEAFGEGEEIIGDEEEAKTVNGLLEGIMGWFVNVRRAFSLESPPPLGSDPELTILMLLHVMALLGELTNLLQPSLRAFLVNEAEVAASLGLNDIVRSLARLFSFMKTQLDNLLSQFPASRVPVQLGPPDLAAAALVEYLVPEDITIPGNGNTAKVSKIQNFSKTIVSEVKKNWVVTNGAVMVRMPATATAGGAVPPSAQAAVGLPSSPSLQGMRYEPWKLQELLERMREVTSRWKLGVEVEWRRGRKKIVCAGGLEGEMSAYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZ42</accession>
    <name>G0RZ42_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0001630</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690712.1">
        <property type="nucleotide sequence ID" value="XM_006690649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZ42"/>
    <dbReference type="STRING" id="759272.G0RZ42"/>
    <dbReference type="GeneID" id="18254201"/>
    <dbReference type="KEGG" id="cthr:CTHT_0001630"/>
    <dbReference type="eggNOG" id="KOG0714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043579_1_0_1"/>
    <dbReference type="OMA" id="ARSREHN"/>
    <dbReference type="OrthoDB" id="1507364at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000069">
        <property type="entry name" value="ER associated DnaJ chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051100">
        <property type="entry name" value="DnaJ_subfamily_B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015399">
        <property type="entry name" value="DUF1977_DnaJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908:SF3">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09320">
        <property type="entry name" value="DUF1977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="48"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS23470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="360" mass="40398" checksum="FEB55772F5C164F6" modified="2011-10-19" version="1">MPDASTTGASTNGDSARRREHNQGNQARKYTPEQEATVQRIRRCNPTAFYEILDIPKTASDAEVKKAYRKLSLLTHPDKNGHPHADEAFKMVARAFSVLGDKEKREKFDKWGTDPDSRFAQAQAQAQAAGAGMGGTGGNPFMGRRGQPMWDEEISPEELFARMFGGPFGGFGGPFGAFDGQQFVFNFGGGPGIRVHHFGGPRPRTRPRNAQNNRDNNNEIPWWTQLAGWLPILILVFWPLISTLISGLTSTFTPATPSMAFDAPNPPLYTLERTMPNLGFKYYLNPADVHSYSAHKLASLDKKAEVVLVQQLRLQCENEMAHKERLREAARGWFYQDQKKMELANNYDMPACRRLHSLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZC6</accession>
    <name>G0RZC6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitotic-spindle organizing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0002490</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2020" name="Cell Rep." volume="31" first="107836" last="107836">
            <title>Promiscuous binding of microprotein mozart1 to gamma-tubulin complex mediates specific subcellular targeting to control microtubule array formation.</title>
            <authorList>
                <person name="Huang T.L."/>
                <person name="Wang H.J."/>
                <person name="Chang Y.C."/>
                <person name="Wang S.W."/>
                <person name="Hsia K.C."/>
            </authorList>
            <dbReference type="PubMed" id="32610137"/>
            <dbReference type="DOI" id="10.1016/j.celrep.2020.107836"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS)</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Required for gamma-tubulin complex recruitment to the microtubule organizing center (MTOC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the gamma-tubulin complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Spindle pole body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MOZART1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690796.1">
        <property type="nucleotide sequence ID" value="XM_006690733.1"/>
    </dbReference>
    <dbReference type="PDB" id="6L7R">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.85 A"/>
        <property type="chains" value="B=1-83"/>
    </dbReference>
    <dbReference type="PDB" id="6L82">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.24 A"/>
        <property type="chains" value="B=1-83"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZC6"/>
    <dbReference type="SMR" id="G0RZC6"/>
    <dbReference type="STRING" id="759272.G0RZC6"/>
    <dbReference type="GeneID" id="18254287"/>
    <dbReference type="KEGG" id="cthr:CTHT_0002490"/>
    <dbReference type="eggNOG" id="ENOG502S6UI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160285_2_0_1"/>
    <dbReference type="OMA" id="ILYEMAQ"/>
    <dbReference type="OrthoDB" id="48571at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000931">
        <property type="term" value="C:gamma-tubulin ring complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031021">
        <property type="term" value="C:interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033566">
        <property type="term" value="P:gamma-tubulin complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051415">
        <property type="term" value="P:microtubule nucleation by interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022214">
        <property type="entry name" value="MZT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520:SF2">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12554">
        <property type="entry name" value="MOZART1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="11 12" id="KW-0002">3D-structure</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS23554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="6L7R"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="6L82"/>
        </source>
    </evidence>
    <sequence length="83" mass="9190" checksum="203282B8A54454B6" modified="2011-10-19" version="1">MPPSERAEKQAAAQQAVDILHEIATILNCHLDRRTLSICISMIENGVNPEALANVIKELRVLGQDPQQLDALVANYLASSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZE1</accession>
    <name>G0RZE1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0002640</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690811.1">
        <property type="nucleotide sequence ID" value="XM_006690748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZE1"/>
    <dbReference type="GeneID" id="18254302"/>
    <dbReference type="KEGG" id="cthr:CTHT_0002640"/>
    <dbReference type="eggNOG" id="ENOG502SUWQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_171231_2_0_1"/>
    <dbReference type="OMA" id="PTRVLRM"/>
    <dbReference type="OrthoDB" id="202195at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010530">
        <property type="entry name" value="B12D"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06522">
        <property type="entry name" value="B12D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="91" mass="10623" checksum="140D0DAB405CB8A5" modified="2011-10-19" version="1">MFATRTLRMFRPTVRMMRPVPKEEQAAHTVSQRLRRLKKIPPELIPLGVVVSFAVCAAVYSTTRHLLVDKNIRLKRQNRAADLHVEKHEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZG1</accession>
    <name>G0RZG1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peroxisomal ATPase PEX1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Peroxin-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0002840</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="513" last="513">
            <title>Cryo-EM structure of the essential ribosome assembly AAA-ATPase Rix7.</title>
            <authorList>
                <person name="Lo Y.H."/>
                <person name="Sobhany M."/>
                <person name="Hsu A.L."/>
                <person name="Ford B.L."/>
                <person name="Krahn J.M."/>
                <person name="Borgnia M.J."/>
                <person name="Stanley R.E."/>
            </authorList>
            <dbReference type="PubMed" id="30705282"/>
            <dbReference type="DOI" id="10.1038/s41467-019-08373-0"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (4.50 ANGSTROMS) IN COMPLEX WITH ATP</scope>
    </reference>
    <reference evidence="13 14 15" key="3">
        <citation type="journal article" date="2022" name="PNAS Nexus" volume="1" first="pgac118" last="pgac118">
            <title>Communication network within the essential AAA-ATPase Rix7 drives ribosome assembly.</title>
            <authorList>
                <person name="Kocaman S."/>
                <person name="Lo Y.H."/>
                <person name="Krahn J.M."/>
                <person name="Sobhany M."/>
                <person name="Dandey V.P."/>
                <person name="Petrovich M.L."/>
                <person name="Etigunta S.K."/>
                <person name="Williams J.G."/>
                <person name="Deterding L.J."/>
                <person name="Borgnia M.J."/>
                <person name="Stanley R.E."/>
            </authorList>
            <dbReference type="PubMed" id="36090660"/>
            <dbReference type="DOI" id="10.1093/pnasnexus/pgac118"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.88 ANGSTROMS) OF 200-802 IN COMPLEX WITH ADP; ATP AND MG(2+)</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690831.1">
        <property type="nucleotide sequence ID" value="XM_006690768.1"/>
    </dbReference>
    <dbReference type="PDB" id="6MAT">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.50 A"/>
        <property type="chains" value="A/B/C/D/E/F=1-802"/>
    </dbReference>
    <dbReference type="PDB" id="7SWL">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.88 A"/>
        <property type="chains" value="A/B/C/D/E/F=200-802"/>
    </dbReference>
    <dbReference type="PDB" id="7T0V">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.67 A"/>
        <property type="chains" value="A/B/C/D/E/F=1-802"/>
    </dbReference>
    <dbReference type="PDB" id="7T3I">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.30 A"/>
        <property type="chains" value="A/B/C/D/E/F=1-802"/>
    </dbReference>
    <dbReference type="PDBsum" id="6MAT"/>
    <dbReference type="AlphaFoldDB" id="G0RZG1"/>
    <dbReference type="EMDB" id="EMD-25474"/>
    <dbReference type="EMDB" id="EMD-25582"/>
    <dbReference type="EMDB" id="EMD-25659"/>
    <dbReference type="EMDB" id="EMD-9063"/>
    <dbReference type="SMR" id="G0RZG1"/>
    <dbReference type="STRING" id="759272.G0RZG1"/>
    <dbReference type="GeneID" id="18254322"/>
    <dbReference type="KEGG" id="cthr:CTHT_0002840"/>
    <dbReference type="eggNOG" id="KOG0733">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_8_4_1"/>
    <dbReference type="OMA" id="QLHMSII"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990275">
        <property type="term" value="F:preribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001602">
        <property type="entry name" value="Cell division cycle protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000149">
        <property type="entry name" value="Nuclear valosin-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="12 13 14" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="235"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="534"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="73"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="120"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="89"/>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
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    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0003590</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the eIF-3 subunit D family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690904.1">
        <property type="nucleotide sequence ID" value="XM_006690841.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0RZN4"/>
    <dbReference type="GeneID" id="18254397"/>
    <dbReference type="KEGG" id="cthr:CTHT_0003590"/>
    <dbReference type="eggNOG" id="KOG1361">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2479">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_248979_0_0_1"/>
    <dbReference type="OrthoDB" id="262529at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098808">
        <property type="term" value="F:mRNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002191">
        <property type="term" value="P:cap-dependent translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16273">
        <property type="entry name" value="SNM1A-1C-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000038">
        <property type="entry name" value="DNA cross-link repair protein pso2/snm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03003">
        <property type="entry name" value="eIF3d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011084">
        <property type="entry name" value="DRMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007783">
        <property type="entry name" value="eIF3d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07522">
        <property type="entry name" value="DRMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05091">
        <property type="entry name" value="eIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 8 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DNA repair metallo-beta-lactamase" evidence="10">
        <location>
            <begin position="1303"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="123"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA gate" evidence="8">
        <location>
            <begin position="304"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="549"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="683"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="140"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="556"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="573"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="601"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="702"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="733"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS23662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1494" mass="164552" checksum="F2D39C2631F23D54" modified="2011-10-19" version="1">MAIPPPGASALVDLINSLPDPDDTWGPPITNETTLNGVPYAPYSKGDKLGRMADWTEAKEGRDGRSRQQYKSYRDQQVYGAGSASLFAAPVAEDEASFSVVSNVRDTGKSRFGRGAVFTRTRTQRTGAARPGRQALGRSGRTGGYGAYDGRGGSRSSGARGRRFGWKDYDKPARARDASINIKPDWKLVEEIDFNRLTKLNLEADEGEDLDSYGFLYYYDRSYDKPPVKNAERKLEVIDRAVYNVTTSSDPVIQELAEKDEGTIFATDSILSMLMCAPRSVYPWDIVLVKQGNKVFLDKRDNAALDMVTVNENAADAPIEGDNSRDGINQPSALAEEATYINHNFANQVVVESQKVNMAHENPFYSASEETEPPASKAYKYRRFDLSTSEEDPVFIVVRTELDAVQKNPTTGEDQFITVHALNEFDSKAPGAGGALDWRTKLVSQRGAVVATEMKNNSCKLARWTVQSILANADTMKIGFVSRASPKVNDKHVILGVIGWKPKDFASQMNLKLSNGWGIVRTIADMVLQRDDGKYVLVKDPNKSILRLYEVPPGGLDEEEEGAEDDENENAEESSSTSSSSATPHKTKTGPNKTPQKRQIRLTQAFSSLTSSGKSTATTKPKQVLLGKEKPNHSILNFFQKAPRPEDEELFVGKGNDCTLLEDEEDEEPQTGAAYLDVGVRDNGEGHEEDIYGATPPQQISHADEGETERFNEAGGPVKRRRLNSEDGNLLESRTEAQSAHEKARDKESLIKKKMKRPGMPFLEDSSSEDEDEKQNSNLRVRSHESSFTVGECISIKDLGPGELTNGTRLDREVPFVWHETPMDEKLGNNEGYDDIPDRAEGCLANPDSDAYMNEEFTGEELEAMRYMEEQARFEMEEDREDSGIDENDAMEECCPVCNGSLAGASVDEATAHVNSCLDGNPTPLPQPKSGVAIDGINIGSRSVKAAIPRQGQPNPIILDDNIVGGRSSSSSSAFAKLMSSHAEDRAWATAAAAEHASRGLPAYKRTCPFYKIMPGFSICVDAFRYGAVKGCKAYFLSHFHSDHYMGLTANWTHGPIYCSKVTGSLVKSQLRTAAKYVVELEFNTTVAVPDTDGVTVTMIPANHCPGSSMFLFEKILSGGRVQRILHCGDFRACPAHVEHPLLKPETVDAISSRTKQQKIDVCYLDTTYLNPRYSFPPQSDVIRACAELCAMLNKSITANDNSVWDGLLCRGKVGHQPGIESVSKFLTVSSSFSSSSSNQKSGSPSTNALTFLGQPRNRLLVVCGTYSIGKERICVGIAQALQTKIYAAPAKLRMCRQLDDPELTALLTSDPREAQVHMHALMDINADTLAQYLQGFKGHFSKIVGFRPSGWNFRPSVSKSAPKNLANLPPNSLPTTQLLHSPQWRPQITARDLVPQRGGNATEAMCFAVPYSEHSSFRELALFLMALQIEKVVPTVNVGNETSRKRMRGWIDRWIAERKRGGLVRVLHERNGNGEDKERLWDGKDGKGGAVYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0S023</accession>
    <name>G0S023_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0008470</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691375.1">
        <property type="nucleotide sequence ID" value="XM_006691312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S023"/>
    <dbReference type="STRING" id="759272.G0S023"/>
    <dbReference type="GeneID" id="18254885"/>
    <dbReference type="KEGG" id="cthr:CTHT_0008470"/>
    <dbReference type="eggNOG" id="KOG2517">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_10_1_1"/>
    <dbReference type="OMA" id="HKAMWHE"/>
    <dbReference type="OrthoDB" id="203824at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019150">
        <property type="term" value="F:D-ribulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019321">
        <property type="term" value="P:pentose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07782">
        <property type="entry name" value="ASKHA_NBD_FGGY_D-RBK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006003">
        <property type="entry name" value="FGGY_RbtK-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01315">
        <property type="entry name" value="5C_CHO_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43435:SF4">
        <property type="entry name" value="FGGY CARBOHYDRATE KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43435">
        <property type="entry name" value="RIBULOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="4">
        <location>
            <begin position="24"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="5">
        <location>
            <begin position="327"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS23184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="609" mass="66564" checksum="415A55B0190D6FCF" modified="2011-10-19" version="1">MQSPEFDNPILHRHRGSSQETESYYVGVDVGTGSARACIIDSTGEIKALASEDIKLWHPSSYGGTHYEQSTTDIWRAVATCIRTCLSTSRVPSTSIKGIGFDATCSLAVFTSDTDEPVPVTYPDFANDGNDRNVILWLDHRALAEAEEINATRHPLLRYVGGTMSPEMEVPKVLWLQRHMPPDLFRKCKFYDLADALTHMATGTETRSFCSAVCKQGYVPVGIDGSIKGWQEDFWRTLGLGELVEEEFARIGGVDGVNGSFLSAGELVGRLSERAAKDFGLPAGIPVGSGVIDAYAGWIGTVGARVGLDPKDEESLPNDVSQAFTRLAAVAGTSTCHLAMSREPVFVPGVWGPYRDVVIPGFWMAEGGQSATGELLKHMLEKHPSYQETLKDAKATGKNIYEFLNGHLRQLASSHKAPFIGYLARHLFFYGDLWGNRSPIADPTMRGAIIGLSSDTSRDNLAITYYATMEFIALQTKQIIQTMNEAGHGIRGIFMSGSQCQNELLVELIATACEMPVVVPRYVNAAVVHGAAMLGAKAGSAGPEGKTEPLWDIMTRMSKPGNVVYSKASEAEKKLLQAKYEVFLDQCRTQREYRRKIDETLEQAELGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0S070</accession>
    <name>G0S070_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0008950</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691422.1">
        <property type="nucleotide sequence ID" value="XM_006691359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S070"/>
    <dbReference type="STRING" id="759272.G0S070"/>
    <dbReference type="GeneID" id="18254933"/>
    <dbReference type="KEGG" id="cthr:CTHT_0008950"/>
    <dbReference type="eggNOG" id="KOG3048">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091867_0_2_1"/>
    <dbReference type="OMA" id="QAKFKAC"/>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990113">
        <property type="term" value="P:RNA polymerase I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990114">
        <property type="term" value="P:RNA polymerase II core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990115">
        <property type="term" value="P:RNA polymerase III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23157">
        <property type="entry name" value="Prefoldin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000004">
        <property type="entry name" value="Probable prefoldin subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011599">
        <property type="entry name" value="PFD_alpha_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00293">
        <property type="entry name" value="prefoldin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674:SF2">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="164" mass="17614" checksum="175095E7707943F9" modified="2011-10-19" version="1">MASRSGQDKGQGEAVDLASLSVQQLSAVKKQLDGEVEHLSTSYAQLVAAQGKFKECLRIVKDRASTFEKDKSVLVPLTNSLYVKGKLSDPEHVLVDVGTGFYVEKDTTSAAEFYEGKIKELATNIQGLEGIVQAKTVNLRVVEEVLRQKVLASNAAGTGAKQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0I3</accession>
    <name>G0S0I3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative mismatched DNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0010120</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the membrane magnesium transporter (TC 1.A.67) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691535.1">
        <property type="nucleotide sequence ID" value="XM_006691472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0I3"/>
    <dbReference type="STRING" id="759272.G0S0I3"/>
    <dbReference type="GeneID" id="18255050"/>
    <dbReference type="KEGG" id="cthr:CTHT_0010120"/>
    <dbReference type="eggNOG" id="KOG0221">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_412181_0_0_1"/>
    <dbReference type="OrthoDB" id="29596at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053279">
        <property type="entry name" value="EMC_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018937">
        <property type="entry name" value="MMgT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28144">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28144:SF1">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10270">
        <property type="entry name" value="MMgT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="152"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="641"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="643"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS23344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="666" mass="72878" checksum="1FD198CC0CE15D8B" modified="2011-10-19" version="1">MALLSKTITAIGGLLLAHACYSAREHTTLQSLQAPSSSLTSSSTSISSLPLDIVVETIVSTFIILVGLVLGTHPLRPVEWRVWAGKIEREGEEGFTNNSGTVDEDYMGNPFSVLESRPNFVDIRKLRREFSDWAQQEEVKQEGGDIVPHAAASAHHGVVPSRPSKNPEAAFMQSGRSSAQGIRLRRPQEHDSISVRSRTSIRPQATTSRPSQRRRLQNTPRSQLAGGAALRLGHFGHIGRSLTEHAKLHTTGSFVLAGFGCADDEQNSDYHNQDMLSEVIMALDVDKDGKVGCAYYITMEEVLVLEEEIPIGGLEAVETLLLHVQPTSILIPNRTQGDLLEFLERDALRLDDSASSSEKGSYVLRELSSAQFDYESGKEALARLELGLSRPDPLQVISAEDEPAQCIGSSAHYSLMRLAETINLESFLSIGCAGAVLHDLERRRATEDQLSDNDRDLIVRTIDFQLSKESGRTEIMQGGVPETVAQHVLHCTVMPQLGFLIGVRLDPRTGEGIYHGQYHLGDEWTLCFTTDEEVEVMMELSAAVLQHEESMLTASELWGELDSFLALALAAEKYNWIAPRMTTSNIIDIVGGRHPLQELIVPAYVPNDCSLAGGHGVGAFDDPELPVSANEKCASPSMLILTGPNNSGKSGNNRSDRSNPYQDCYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0N1</accession>
    <name>G0S0N1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0010620</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691583.1">
        <property type="nucleotide sequence ID" value="XM_006691520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0N1"/>
    <dbReference type="STRING" id="759272.G0S0N1"/>
    <dbReference type="GeneID" id="18255100"/>
    <dbReference type="KEGG" id="cthr:CTHT_0010620"/>
    <dbReference type="eggNOG" id="ENOG502SG5D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_375044_0_0_1"/>
    <dbReference type="OrthoDB" id="2257100at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050946">
        <property type="entry name" value="AP-1_TF_bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11462">
        <property type="entry name" value="JUN TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11462:SF35">
        <property type="entry name" value="TRANSCRIPTION FACTOR JRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
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    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="662"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="43"/>
            <end position="363"/>
        </location>
    </feature>
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        <location>
            <begin position="586"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="680"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
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        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
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        <location>
            <begin position="329"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="586"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGS22591.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="740" mass="78395" checksum="5358CFF5C774A612" modified="2011-10-19" version="1">MEIDMLLDTRNDLEAQMGEDDSLFVPGPAQLVFQVSPFLAQFASSQGLRSRSDEGEETPPPDLVTPTESSDLDEGDGMNTDEQSTPPTPDGVAPPQNSPVPFFLPMRPAASSIEIPTTAAGPLGPPAETPDPAAGPSNTQNEHTKASTGSPENQAEPSEGSIEAPEVTNAPADAGAEHPETPESRGTQKPMEALSRPSNPSIESSQMAGHAGSSAALPEASTEPLEPVNGSLETSNTNPESPVDHAEMSLKAQETKSGHTTEVSKPLVESPDPSIPLSATPSGPHQPMIEPSEICQESPSSVTPSTLSNPFASPSQVPRPDTPETSIEPPHPSPEPEPAAEPTPVSLPESAPEPAPSSSPQLPRHLEIQEIPEFKPRNLHTCQICLRMLPQDEGQSTSRLLKTPSGEHVFSAVSTFNCHQTALSTLPAPEHPCGLCFNEAARTSLQEWPPQLHLPPPTSAASPSSCPNLCHQEDLGLGTLADKNLFCFDFSNDLLQWNQTVPITAADVETAVQTLSDTTLLTPEVDPDLAACLSALQPSLAVSVSDDSFVAFPVTSLSAGSGSSPAALSDSLVTPQISTTLTPESATITCSQSPSVAQTTSETSDTSTPGLIPGLKLPPPKEPKRRPGRKPGSSSILHSVADGRVIKTLGTTTPQIQEYEVDETTLIRRYRNNLAAKRCRQKKLDRITELEEEVKRVMSERDELRIALAKREAEVRALREMLRLATSTGESLKVGNGGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
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            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
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                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
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                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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            <begin position="1"/>
            <end position="18"/>
        </location>
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            <begin position="19"/>
            <end position="102"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGS22603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="102" mass="10181" checksum="F647CBACADA9811C" modified="2011-10-19" version="1">MRLATILSAVVLPLAALAAEEKITTVTSTTEVTLTKTVTLRRAQVTGHVNGTVVYTTTPTATATTTSEAAAATATDENAGSAFAPAKFAAAAFASLVAAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0P5</accession>
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        <lineage>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
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                <person name="Flemming D."/>
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                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
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                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
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        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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            <end position="27"/>
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            <end position="174"/>
        </location>
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        </location>
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            <end position="122"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="174" mass="18021" checksum="EAF82DCC301354AE" modified="2011-10-19" version="1">MVRLSRISTQVTFLAPLLLQGISQLSAALVSPYDQTSHDILGLSPTPSPSTIFPVPAEPHVALERDKSILADSVPVIISQETELISDNIALEPRTPKGGRGGNSSSGSSSGSSSGSSSQNSGPIAADSGSHANSNTSPDDSTTTHKPKKPKVKGCSEDISEFQELGMGLTLVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0X2</accession>
    <name>G0S0X2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative pre-mRNA splicing factor</fullName>
        </submittedName>
    </protein>
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    <organism evidence="11">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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    <dbReference type="STRING" id="759272.G0S0X2"/>
    <dbReference type="GeneID" id="18255193"/>
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    <dbReference type="eggNOG" id="KOG0007">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013259_3_1_1"/>
    <dbReference type="OMA" id="VKYQEQQ"/>
    <dbReference type="OrthoDB" id="447637at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Splicing factor 3A subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Splicing factor 3a, subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SF3A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022030">
        <property type="entry name" value="SF3A1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316">
        <property type="entry name" value="SPLICEOSOME ASSOCIATED PROTEIN 114/SWAP SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316:SF1">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12230">
        <property type="entry name" value="PRP21_like_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="SURP motif" evidence="9">
        <location>
            <begin position="38"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="SURP motif" evidence="9">
        <location>
            <begin position="138"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="314"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="208"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="334"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS22682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="534" mass="59091" checksum="A25FA2317CDA6239" modified="2011-10-19" version="1">MPGPTTNGDAAAAAAAQLDNLKPPPGIIIPPPGEIREAIEKTAGYVMRGGAGLEQRIRDNHGKNPKFSFLMSPNDPYNAYYEWRKAEIRAGRGTAISAGRVGEAAATPATAKPAGPPKPPDFQFSARMPRMSQKDLEIVRLTALFVAKNGRQFMTQLAQREAGNPQFQFLIPNHTFHNFFQSMIDQYTILLRDSGVNGEGSKAQQDRIEELRQNVADKYRILTRAKQRAEYAKWQEAEKAKKEEEAEKKKLEFARIDWNDFVVVETIIFTEADDQANLPPPTTLNDLQYASLEERNKVSISSALRIEEAFPFDDTSYNAHPPPPAYATQAPAAQPIPAPAPTPAPTPAPVSQAYGTSAPVADRTKPTGHEAPAQNEQDRLRPQPVQAAGGPVPMKIKENYVPRAAQRAANKFGTQTAMCPNCKQQIPLSEMDEHMRIELLDPRWKEQKAKAEARYATTNLSTVDVANNLKRLASQRSDVFDTSTGQTVSEEELARRKKVALGTADNTPDGRSQMQTFNLDEQIRAIHQKFADKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0Y6</accession>
    <name>G0S0Y6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA polymerase eta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0011690</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691688.1">
        <property type="nucleotide sequence ID" value="XM_006691625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0Y6"/>
    <dbReference type="STRING" id="759272.G0S0Y6"/>
    <dbReference type="GeneID" id="18255207"/>
    <dbReference type="KEGG" id="cthr:CTHT_0011690"/>
    <dbReference type="eggNOG" id="KOG2095">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012348_7_1_1"/>
    <dbReference type="OMA" id="AWPCSNL"/>
    <dbReference type="OrthoDB" id="5723at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009314">
        <property type="term" value="P:response to radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000009">
        <property type="entry name" value="DNA polymerase eta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000008">
        <property type="entry name" value="DNA polymerase eta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000014">
        <property type="entry name" value="Polymerase (DNA directed), eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052230">
        <property type="entry name" value="DNA_polymerase_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873:SF1">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21704">
        <property type="entry name" value="POLH-Rev1_HhH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UmuC" evidence="13">
        <location>
            <begin position="63"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS22696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="507" mass="56894" checksum="C7194C9CAEC3B8A4" modified="2011-10-19" version="1">MQQPLAPNVWDVQQTSWSNNDMPPRECAREDSSVSNPRRCSQFTFRHLSQMASCIPSSPLRVVAHIDLDCFYAQVEMVRLGIAEDTPFAVQQWQGLIAVNYPARSYGIGRHCTITEAKKLCPKLITQHVATWREADGKWAYREDPQVATDKVCLDPYRSESRKILVLIKELLPHGLQRVEKASIDEVFLDLSAHVHAILLERFPELLSPQPHRDLSELLPLPPISDLDWQADTLVDAGDSDNKTLAILDPDWDDVAFYVASGIVRHLRSSIKEKLGYTCSAGIARNKLLSKLGSSYKKPNQQTVIRNRAVAHFLSGVKFTKIRNLGGKLGEQVSRAFNTDSIPDLLTVPIEQMKVKLGDETAIWLYNTLRGVDMSEVNPRIQIKSMLSAKSFRPTLTTIDQAVRWLRIFAADIFSRLVEEGVLEHRRHPKTINLHYRPLGGQARSRSCPIPQGRALDDGTLFDLAKTLLTHIVQDGNVWPCAGLSLSVGSFEDSVSAIVCEHNLLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1S0</accession>
    <name>G0S1S0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0014590</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691972.1">
        <property type="nucleotide sequence ID" value="XM_006691909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1S0"/>
    <dbReference type="GeneID" id="18255497"/>
    <dbReference type="KEGG" id="cthr:CTHT_0014590"/>
    <dbReference type="eggNOG" id="KOG1944">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049109_3_1_1"/>
    <dbReference type="OMA" id="DWVPVFQ"/>
    <dbReference type="OrthoDB" id="10267969at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF80">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS22980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="238" mass="26436" checksum="D36A4C2FCABF9A2E" modified="2011-10-19" version="1">MALSPIARSTLQAALISAISNILAQFIAAHQAGQPFAFNPIPTLQYTLYALLSTPPNFMWQEYLESIFPSYTSQEDGDNKSEIKRMQEQPRLNKINTLIKTILDQTLAAVLNNLAFCLALGGMRMGMAKQASEFLRLQQQHHSQNQSPAGSFILSLLLLLEAFSKTGGPMRYEDVNWAVVWEQAKSELWGLMIVSWQFWPLVSVVNYAFLTSVEARTLIGSLAGLAWGVYLSLYAGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1V5</accession>
    <name>G0S1V5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">N-acetyltransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0014970</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Int. J. Mol. Sci." volume="23" first="10805" last="10805">
            <title>Extended N-Terminal Acetyltransferase Naa50 in Filamentous Fungi Adds to Naa50 Diversity.</title>
            <authorList>
                <person name="Weidenhausen J."/>
                <person name="Kopp J."/>
                <person name="Ruger-Herreros C."/>
                <person name="Stein F."/>
                <person name="Haberkant P."/>
                <person name="Lapouge K."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="36142717"/>
            <dbReference type="DOI" id="10.3390/ijms231810805"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.10 ANGSTROMS) OF 82-289</scope>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS23015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692007.1">
        <property type="nucleotide sequence ID" value="XM_006691944.1"/>
    </dbReference>
    <dbReference type="PDB" id="7OJU">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.10 A"/>
        <property type="chains" value="A=82-289"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1V5"/>
    <dbReference type="SMR" id="G0S1V5"/>
    <dbReference type="STRING" id="759272.G0S1V5"/>
    <dbReference type="GeneID" id="18255535"/>
    <dbReference type="KEGG" id="cthr:CTHT_0014970"/>
    <dbReference type="eggNOG" id="KOG3138">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054412_0_0_1"/>
    <dbReference type="OMA" id="HGIAMHL"/>
    <dbReference type="OrthoDB" id="47374at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051556">
        <property type="entry name" value="N-term/lysine_N-AcTrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919:SF8">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="86"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="322"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="334"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="355"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="417"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS23015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="7OJU"/>
        </source>
    </evidence>
    <sequence length="445" mass="46676" checksum="9B88535CAE8EA2B7" modified="2011-10-19" version="1">MSASRQASIKSFFQPRGLPTHNTTFSSKTPPTDRATQTTTPPPVPPPAPAPPSHQPAAPEPITISVRLPPGGVPNLPSPPSLPSGASIVPLAQEHIPALRRINSLLLPVAYPDSFYHKALDPLASGLFSRAILWQDTNADPPKVVGGLICRLEPNPFLSVTGEPTPVQLPADQPQRAPQAPKDTPFHAIYIQSLALLSPYRSLGLAAAALDHIIATAAVLPAAGSNIDARTIYAHVWTENEEGLKWYESRGFVKEGGEPVKGYYFKLRPDTAWIVRRHIGESAKLNDVVSQPQPQPQQQLQQQPAVDIAPTATSVLAAAVNLPPITSTPPPPSTGSKLPTSNTSTLASRPPPPLRSTSSSTSSATSLSYQNTRPPTEWNDIPPDMVAGPPIAARGRRVTAAAASDPAANGCSGTGSGASSRSASAAAGTGKKRKGRDYPTAAFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0S248</accession>
    <name>G0S248_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP citrate synthase</fullName>
            <ecNumber evidence="4">2.3.3.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CTHT_0015970</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>oxaloacetate + acetyl-CoA + ADP + phosphate = citrate + ATP + CoA</text>
            <dbReference type="Rhea" id="RHEA:21160"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.3.3.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.8" evidence="4"/>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS23108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692100.1">
        <property type="nucleotide sequence ID" value="XM_006692037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S248"/>
    <dbReference type="STRING" id="759272.G0S248"/>
    <dbReference type="GeneID" id="18255635"/>
    <dbReference type="KEGG" id="cthr:CTHT_0015970"/>
    <dbReference type="eggNOG" id="KOG1254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006587_3_1_1"/>
    <dbReference type="OMA" id="DMHVSGI"/>
    <dbReference type="OrthoDB" id="5295093at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042709">
        <property type="term" value="C:succinate-CoA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003878">
        <property type="term" value="F:ATP citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000004">
        <property type="entry name" value="ATP-citrate synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.110:FF:000003">
        <property type="entry name" value="ATP-citrate synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032263">
        <property type="entry name" value="Citrate-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056749">
        <property type="entry name" value="Citrate_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815:SF10">
        <property type="entry name" value="SUCCINATE--COA LIGASE [GDP-FORMING] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="SUCCINYL-COA SYNTHETASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16114">
        <property type="entry name" value="Citrate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24948">
        <property type="entry name" value="Citrate_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-citrate synthase ATP-grasp" evidence="15">
        <location>
            <begin position="2"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase citrate-binding" evidence="14">
        <location>
            <begin position="298"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF24948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGS23108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="489" mass="53509" checksum="C6B6BDA825A0E31F" modified="2011-10-19" version="1">MSAKSIYEADGKAILNYHLTRAPVIKPSPLPPPAEHNPPPKLASLRFPEGADINAVLDKAEKTYPWLLEPGARFVAKPDQLIKRRGKSGLLALNKTWAEARAWVAERAGKPQQVEHTVGILRSFLVEPFVPHPPETEYYININSVRDGDWILFTHEGGVDVGDVDAKAEKLLIPVDLSEYPSNEEIAATLLKNVPKGLHNVLVDFITRLYAVYVDCQFTYLEINPLVVIPNEDCTSASVHFLDLAAKLDQTADFECGQKWAIARAPQNLGIVVDDEPQNSTVNIDAGPPMEFPAPFGRELSKEEAYIAELDAKTGASLKLTVLNPNGRIWTLVAGGGASVVYADAIASAGFADELANYGEYSGAPTESQTYHYARTVLDLMLRAPMHPKGKVLFIGGGIANFTNVASTFKGVIKALREYAKALNEHNVQIWVRRAGPNYQEGLKNMKAATQELGLNAKIFGPEMHVSGIVPLALIPGKWEENTIKEFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0S266</accession>
    <name>G0S266_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Calcium/calmodulin dependent protein kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0016150</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692118.1">
        <property type="nucleotide sequence ID" value="XM_006692055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S266"/>
    <dbReference type="STRING" id="759272.G0S266"/>
    <dbReference type="GeneID" id="18255653"/>
    <dbReference type="KEGG" id="cthr:CTHT_0016150"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_0_1"/>
    <dbReference type="OMA" id="RPKVQPC"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000257">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000153">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="334"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="351"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="376"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS22099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="475" mass="52233" checksum="63DF0BCDBDDA8448" modified="2011-10-19" version="1">MNTQQPAAQPQQPVIQPCRYKVGKVLGAGSYSVVKECIHIDTGRYYAAKVINKRLMAGREHMVRNEIAVLKKVSMGHQNILTLVDYFETMNNLYLVTDLALGGELFDRICRKGSYYESDAADLIRAVLSAVAYLHDHGIVHRDLKPENLLFRTPEDNADLLIADFGLSRIMDEEQFHVLTTTCGTPGYMAPEIFKKTGHGKPVDMWALGVITYFLLCGYTPFDRDTDYEEMQAILNADYSFTPIEYWRGVSEHAKDFIRRCLTIDPNKRITAHQALQHPFVNQWARNNASDGSDKGTNLLPTVKKNFNARRTLHAAIDTVRAINKLREGQAGFMNGARSKEPGRDAPPGPAAAAAQQQQQGLAPPREEHNGGKDSGYSSAAHTITSSQPTTVASSHVQQQENMEDVPMDDTPAPMPHLQTLQPSPSPGAPAEQHQSNLPPAFAVPASLRPGSEVNRVVETSKGLWPGGGGGGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2G0</accession>
    <name>G0S2G0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0017100</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692212.1">
        <property type="nucleotide sequence ID" value="XM_006692149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2G0"/>
    <dbReference type="STRING" id="759272.G0S2G0"/>
    <dbReference type="GeneID" id="18255748"/>
    <dbReference type="KEGG" id="cthr:CTHT_0017100"/>
    <dbReference type="eggNOG" id="ENOG502R2EP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022034_0_0_1"/>
    <dbReference type="OMA" id="HPESPRT"/>
    <dbReference type="OrthoDB" id="428854at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="478"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="675"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="756" mass="77963" checksum="96DF8008FE86159B" modified="2011-10-19" version="1">MTSRDHQQQSQGHARTPSVNTNNPFRRRAAGGSTSAPLTVTVPVAAGVFDEWDKEPEVTSSIPTTTEPYRFPSAAAQGTADGHPVRSNAPPAPPPPPPPPSSSFRKEGKVVKKVRVQSPPPSSREDSEGEDAGPSEGHKSQGRNVTLDERGEEDPFESADNEGDQVYCSDYDKEDGTKPPPNPFQRTLQDLERETVKKEGVNNTLGQEKKATLDVQAFKKLLLTGKVDIPESETAQQQQGPGMPPRNLASHDTTLSIAHDSPRASLEGTGEGDERRGLVSQSPVPQPHPTPTAPPKKKPPPPSSRHGRLIRPGTESEPSPTGPESTLGTVKSPPRPRLGTSAGPDVYVNKSPLPPPKRSPAEEESESAYNRRAAGKVPEPVVEGGLGITQITQSPAPATPSPGVPTSLSHQQTQALNTSSNAKKPAPPPRRQPGHSRSESRTTSTLPISPTTLVPGPQAQQQDDAGDSLRRASMDSILSRSSSLRVSVSGAAPPAPPPPRRASHVPKGSVSLSVPGTAPGAGLDGTADAPLTPGGLAEAPSIVAGLNTNLAPVGVPPRPPSRQQHLRAPSIAISPTSTITNNGKSAPTPPPPPPTRHSSVRAKRPGSSSSNAATPGPQVTERKGSTAGLPMTPPPPPPPPSRRRGTALGSVSSIGGMVSPTSGIALTPKTPPGAVPGATTTPPTGAATGVPGAGTTGVNGVAVEEASSRLAVSTARGEVETGSVDFEVPESVAGDLLADLSELQREVDALRGKLGT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-06-24" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2G1</accession>
    <accession>G0ZGV2</accession>
    <name>ELYS_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein ELYS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ELYS</name>
        <name type="ORF">CTHT_0017110</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the assembly of a functional nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 4">The nuclear pore complex (NPC) constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. The 55-60 MDa NPC is composed of at least 28 different subunits: AMO1, ELYS, GLE1, GLE2, MLP1, NDC1, NIC96, NSP1, NUP133, NUP145, NUP152, NUP159, NUP170, NUP188, NUP192, NUP37, NUP49, NUP53, NUP56, NUP57, NUP82, NUP84, NUP85, POM152, POM33, POM34, SEC13 and SEH1. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof.</text>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-16069391">
            <id>G0S2G1</id>
        </interactant>
        <interactant intactId="EBI-16069242">
            <id>G0S0E7</id>
            <label>NUP120</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>6</experiments>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-16069391">
            <id>G0S2G1</id>
        </interactant>
        <interactant intactId="EBI-16069276">
            <id>G0SAK3</id>
            <label>NUP145</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>5</experiments>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-16069391">
            <id>G0S2G1</id>
        </interactant>
        <interactant intactId="EBI-16069259">
            <id>G0SDQ4</id>
            <label>NUP85</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>7</experiments>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ELYS family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JF276296">
        <property type="protein sequence ID" value="AEL00690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692213.1">
        <property type="nucleotide sequence ID" value="XM_006692150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2G1"/>
    <dbReference type="SMR" id="G0S2G1"/>
    <dbReference type="DIP" id="DIP-60576N"/>
    <dbReference type="IntAct" id="G0S2G1">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S2G1"/>
    <dbReference type="TCDB" id="1.I.1.1.2">
        <property type="family name" value="the nuclear pore complex (npc) family"/>
    </dbReference>
    <dbReference type="GeneID" id="18255749"/>
    <dbReference type="KEGG" id="cthr:CTHT_0017110"/>
    <dbReference type="eggNOG" id="ENOG502S4G4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070360_0_0_1"/>
    <dbReference type="OMA" id="EGLWHLD"/>
    <dbReference type="OrthoDB" id="20729at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025151">
        <property type="entry name" value="ELYS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13934">
        <property type="entry name" value="ELYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0509">mRNA transport</keyword>
    <keyword id="KW-0906">Nuclear pore complex</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000433194" description="Protein ELYS">
        <location>
            <begin position="1"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q8WYP5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="21784248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000305" key="4">
        <source>
            <dbReference type="PubMed" id="21784248"/>
        </source>
    </evidence>
    <sequence length="299" mass="33051" checksum="85B3B12EB1C9BFC5" modified="2011-10-19" version="1">MLDFTHFPEVFPTDGPRPYDQHFVRQTETFRKSLDGVLFIDRVLGALGLPDAAKAYPPRGDAGLRALHQQVCSAKVSAHAKLSVLYYLLLDHDEHRGSRSQLADALAEEVGLPANYQILMRGLWHMDRKEFKFALEHLAHPSLPAEFADEIITVLVRDGHTTGDYSLPLAYYHAVRPVLQTSSALENLFAALARTSVTDALAFSRTYPDHGARQLLFERLVASVLEEHGSGQVAGRSASRAKELVSLPLTGVEEKWLNDYLSTGEGRKSRSAKAVVQMRQVVTGRQKELGAVVGVRAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2T1</accession>
    <name>G0S2T1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0018380</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692333.1">
        <property type="nucleotide sequence ID" value="XM_006692270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2T1"/>
    <dbReference type="GeneID" id="18255876"/>
    <dbReference type="KEGG" id="cthr:CTHT_0018380"/>
    <dbReference type="HOGENOM" id="CLU_485702_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="561" mass="62177" checksum="41CA62156A08CE47" modified="2011-10-19" version="1">MARSHSPSLSEDWEEISDRFSVISLPDTPRLSPRIGPANSKIAVPAVAKLNEIAARPDRTNDYNEQFSTSDSHSKLDDDRTAGRTQSSDEDQANQRSQEDDPSQPAIQKHAFSSTTARPRPIPRPIPRIPPSSYTSPSPTVTSTRPISRRFSPLRQISRPTPAELASPAMRNTVSPVVNITTTSSLNSTPNPSPDSFTSPSQTARPPLRLPYITPSSLRTLLIETAKEFGETARKSPLTERTSSLCQQLELMVYSWKGRSQNYKWCAEMYELVRELRVKTRQAVERERRGKKCLPECRDTREVDEVYEKVMELWKGRDGTSWRGSGIGSGGRVTGWRVISPRGGGMTMTGSLETQTGLLEGDGNRRMSEESCYGTEDNSAGYDGYFGDLEPVVARERKACRHPSLESEREMMERPPPYKERSRLAEPAGGYPAPVIQIPPPPPVGWAFYPEPRSYQAEGRYWGRERSTTAPGVQEELAFWRRMDGVAEATGRMRDKVISGGRGETGTCMEHVAGRDGDGWGEDEESLPRALSSLEPETLSGQTILETAAAVVRMVAGSLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>G0S348</accession>
    <name>G0S348_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0019640</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692450.1">
        <property type="nucleotide sequence ID" value="XM_006692387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S348"/>
    <dbReference type="GeneID" id="18256002"/>
    <dbReference type="KEGG" id="cthr:CTHT_0019640"/>
    <dbReference type="HOGENOM" id="CLU_667313_0_0_1"/>
    <dbReference type="OMA" id="MAPMAMG"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408788" evidence="2">
        <location>
            <begin position="21"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="412" mass="40763" checksum="0E4A707BF75D7CE3" modified="2011-10-19" version="1">MKLTFSTLTLLFLFASPYLAFPTNPSTANAHTSEGAPKVAGDTNNHGKRTAAGGGVKTVNASDGLNTDGHGLNATAADAAKTVHETTPVAKDATAGEMLYFFPVSAPIAEDISAAVDMDTSNLYGTGYNTNPKSDANTDVNSANGPAADNAKATATETDHTIRPPMGPMGMGMGMAPMDMGMGMPMMGMGMAPMAMGMGMRPGMMGMGMPMPVMMPGLSPLPGMAMPVPVDPVPAPAPVVPAGTVPPAGGVPAAVRPVNARGWVEVDTEEKFGGGGGRYGKRDATSSEKEGHAPTPDAGFNWVGETEGVNKEYAKRQMGGMAGMRGGYPGTGYGGGYYVYGYPRYGGYAIGYGRGGYGGVGYGAGGYGRGTGGYAGGMGGIGGGGMGGGMGGMGGMGGGGGMGGGGGGGGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3C3</accession>
    <name>G0S3C3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0020500</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692525.1">
        <property type="nucleotide sequence ID" value="XM_006692462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3C3"/>
    <dbReference type="GeneID" id="18256088"/>
    <dbReference type="KEGG" id="cthr:CTHT_0020500"/>
    <dbReference type="HOGENOM" id="CLU_2573673_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="81" mass="8628" checksum="A057EE69BB9B27B7" modified="2011-10-19" version="1">MKPSPCAASPAHNTPSASFPFNPLIHVPANVPASMTGKMGKIQAGVIFPIVSLLSRLTVNKGKAQGDSYRGEEEEDHIEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3F5</accession>
    <name>G0S3F5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0020830</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692557.1">
        <property type="nucleotide sequence ID" value="XM_006692494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3F5"/>
    <dbReference type="STRING" id="759272.G0S3F5"/>
    <dbReference type="GeneID" id="18256121"/>
    <dbReference type="KEGG" id="cthr:CTHT_0020830"/>
    <dbReference type="eggNOG" id="ENOG502SJ2P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030289_0_0_1"/>
    <dbReference type="OMA" id="QEFAHNN"/>
    <dbReference type="OrthoDB" id="2739686at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38792">
        <property type="entry name" value="BNR/ASP-BOX REPEAT DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G06430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38792:SF3">
        <property type="entry name" value="BNR_ASP-BOX REPEAT DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G06430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS22538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="375" mass="41554" checksum="B53D97313B4AC8EA" modified="2011-10-19" version="1">MDVPHSLPNRQFHVAPSEHFIHSVHGTYPRLCRLPDGSLLAGYTTFSTLATDDTNHTVNEHILTIARSTDNGHSFSPWGEVARSAGDLDNLFLLPLPNSETVLAAFRNHDLSPEDGKMHTFFRITVCESTDAGQTWHFLSQAAEKEAPFGFWEPFLRLGSEPGEIQLYFSQEFAPDDQNTMLTRSFDGGRTWSTPVIVTGEGERLRDGMVGLAKTWDCFYIGNGDEEGEEGEKTRREALALVMETTRHGPFSIEAVLSYDGGHTFGHRQVVYEPRHGKHAGAPQIASFVDGSVAVVFMTDEDGDGRSHWPHGAQIKVVFSGPPINGRFHWTSPMVVGDSPSFWPGIMRVGDHQVLAVYELSSSIRGKILSVTSWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3S3</accession>
    <name>G0S3S3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase</fullName>
            <ecNumber evidence="5">2.7.8.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">GlcNAc-1-P transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">N-acetylglucosamine-1-phosphate transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CTHT_0030450</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transfering GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UMP</text>
            <dbReference type="Rhea" id="RHEA:13289"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.7.8.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:13290"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 4 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.15" evidence="5"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693495.1">
        <property type="nucleotide sequence ID" value="XM_006693432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3S3"/>
    <dbReference type="STRING" id="759272.G0S3S3"/>
    <dbReference type="GeneID" id="18257083"/>
    <dbReference type="KEGG" id="cthr:CTHT_0030450"/>
    <dbReference type="eggNOG" id="KOG2788">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029942_1_0_1"/>
    <dbReference type="OMA" id="LPHFNAR"/>
    <dbReference type="OrthoDB" id="10262326at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003975">
        <property type="term" value="F:UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06855">
        <property type="entry name" value="GT_GPT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033895">
        <property type="entry name" value="GPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571:SF0">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="188"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGS21199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="482" mass="53483" checksum="F1C3E393F35838AA" modified="2011-10-19" version="1">MTSTSNSTRSSSPLSNGLPTTLSRNEALSLATVTAACVAVLVNVFREPEPSPLIASLALSGLAFVAAFALIRWLGPTFLRAGIKGADLSKRVRRELPECMGGVCAVVYLLAVIVFIPFPFYKDIVAATSGGGNKDVVLPVEHVQRGRFLHRFPHSKLASYLSAIISLQSIALLGIGDDLFDIRWRHKFFIPAFAAIPLLVVYFVDFGVTSVVIPIQLQPYLGELLDLGALYYVYMAAVAIFSPNSINILAGINGIEVAQSIVIALLLSLNDCLYLLTPYPHPATDSHLFSLYFLLPFLGVSLALLYHNWYPARVFVGDTYCYFAGMVFVVVSILGHFSKTLVLLLVPQIFNFLYSTPQLFGLVPCPRHRLPRFNARTNLLEPSVTQWTPDHQPKAPIAWVLRLLGRLRLLRVTLDDEDRFVETSNFTLLNLWLVWRGPLREDRLALEITVLQAALGLFGLFVRHRLALLVFKADNWSLGFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3V7</accession>
    <name>G0S3V7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">KRR1 small subunit processome component</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">KRR-R motif-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0039040</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Cell" volume="166" first="380" last="393">
            <title>Architecture of the 90S Pre-ribosome: A Structural View on the Birth of the Eukaryotic Ribosome.</title>
            <authorList>
                <person name="Kornprobst M."/>
                <person name="Turk M."/>
                <person name="Kellner N."/>
                <person name="Cheng J."/>
                <person name="Flemming D."/>
                <person name="Kos-Braun I."/>
                <person name="Kos M."/>
                <person name="Thoms M."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="27419870"/>
            <dbReference type="DOI" id="10.1016/j.cell.2016.06.014"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (7.30 ANGSTROMS)</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="journal article" date="2017" name="Nat. Struct. Mol. Biol." volume="24" first="954" last="964">
            <title>3.2-A-resolution structure of the 90S preribosome before A1 pre-rRNA cleavage.</title>
            <authorList>
                <person name="Cheng J."/>
                <person name="Kellner N."/>
                <person name="Berninghausen O."/>
                <person name="Hurt E."/>
                <person name="Beckmann R."/>
            </authorList>
            <dbReference type="PubMed" id="28967883"/>
            <dbReference type="DOI" id="10.1038/nsmb.3476"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.20 ANGSTROMS)</scope>
    </reference>
    <reference evidence="18 19 20" key="4">
        <citation type="journal article" date="2019" name="Mol. Cell" volume="75" first="1256" last="1269.e7">
            <title>Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration.</title>
            <authorList>
                <person name="Cheng J."/>
                <person name="Bassler J."/>
                <person name="Fischer P."/>
                <person name="Lau B."/>
                <person name="Kellner N."/>
                <person name="Kunze R."/>
                <person name="Griesel S."/>
                <person name="Kallas M."/>
                <person name="Berninghausen O."/>
                <person name="Strauss D."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="31378463"/>
            <dbReference type="DOI" id="10.1016/j.molcel.2019.06.032"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.50 ANGSTROMS)</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. Essential for vegetative growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. Interacts with snoRNA U3. Interacts with MPP10, KRI1 and with ribosomal proteins RPS1A, RPS4A, RPS4B, RPS8A, RPS8B, RPS11A, RPS11B, RPS13, RPS24, RPS25, RPL4A, RPL7B, RPL8, RPL23, RPL25 and RPL28.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
            <location evidence="1 11">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the KRR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS22019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006694252.1"/>
    </dbReference>
    <dbReference type="PDB" id="5JPQ">
        <property type="method" value="EM"/>
        <property type="resolution" value="7.30 A"/>
        <property type="chains" value="g/h=1-322"/>
    </dbReference>
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        <property type="method" value="EM"/>
        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="g=1-322"/>
    </dbReference>
    <dbReference type="PDB" id="6RXT">
        <property type="method" value="EM"/>
        <property type="resolution" value="7.00 A"/>
        <property type="chains" value="CP=1-322"/>
    </dbReference>
    <dbReference type="PDB" id="6RXU">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.50 A"/>
        <property type="chains" value="CP=1-322"/>
    </dbReference>
    <dbReference type="PDB" id="6RXV">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.00 A"/>
        <property type="chains" value="CP=1-322"/>
    </dbReference>
    <dbReference type="PDB" id="6RXX">
        <property type="method" value="EM"/>
        <property type="resolution" value="7.10 A"/>
        <property type="chains" value="CP=1-322"/>
    </dbReference>
    <dbReference type="PDB" id="6RXY">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.70 A"/>
        <property type="chains" value="CP=1-322"/>
    </dbReference>
    <dbReference type="PDB" id="6RXZ">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.40 A"/>
        <property type="chains" value="CP=1-322"/>
    </dbReference>
    <dbReference type="PDBsum" id="5JPQ"/>
    <dbReference type="PDBsum" id="5OQL"/>
    <dbReference type="PDBsum" id="6RXT"/>
    <dbReference type="PDBsum" id="6RXU"/>
    <dbReference type="PDBsum" id="6RXV"/>
    <dbReference type="PDBsum" id="6RXX"/>
    <dbReference type="PDBsum" id="6RXY"/>
    <dbReference type="PDBsum" id="6RXZ"/>
    <dbReference type="AlphaFoldDB" id="G0S3V7"/>
    <dbReference type="EMDB" id="EMD-10051"/>
    <dbReference type="EMDB" id="EMD-10052"/>
    <dbReference type="EMDB" id="EMD-10053"/>
    <dbReference type="EMDB" id="EMD-10054"/>
    <dbReference type="EMDB" id="EMD-10055"/>
    <dbReference type="EMDB" id="EMD-10056"/>
    <dbReference type="EMDB" id="EMD-3847"/>
    <dbReference type="SMR" id="G0S3V7"/>
    <dbReference type="IntAct" id="G0S3V7">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S3V7"/>
    <dbReference type="GeneID" id="18257942"/>
    <dbReference type="KEGG" id="cthr:CTHT_0039040"/>
    <dbReference type="eggNOG" id="KOG2874">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040185_0_2_1"/>
    <dbReference type="OMA" id="TPDIDKW"/>
    <dbReference type="OrthoDB" id="441223at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22393">
        <property type="entry name" value="KH-I_KRR1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22394">
        <property type="entry name" value="KH-I_KRR1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000011">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000014">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041174">
        <property type="entry name" value="KRR1-like_KH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048550">
        <property type="entry name" value="KRR1-like_KH1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048548">
        <property type="entry name" value="KRR1-like_KH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048549">
        <property type="entry name" value="KRR1-like_KH2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024166">
        <property type="entry name" value="rRNA_assembly_KRR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581">
        <property type="entry name" value="HIV-1 REV BINDING PROTEIN 2, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581:SF0">
        <property type="entry name" value="KRR1 SMALL SUBUNIT PROCESSOME COMPONENT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17903">
        <property type="entry name" value="KH_KRR1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21800">
        <property type="entry name" value="KH_KRR1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006515">
        <property type="entry name" value="KRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="16 17 18" id="KW-0002">3D-structure</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 11" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="K Homology" evidence="13">
        <location>
            <begin position="118"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="272"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="272"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="311"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS22019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="5JPQ"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PDB" id="5OQL"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PDB" id="6RXT"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="19">
        <source>
            <dbReference type="PDB" id="6RXU"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PDB" id="6RXV"/>
        </source>
    </evidence>
    <sequence length="322" mass="37423" checksum="5FBE07B66BF6BF2A" modified="2011-10-19" version="1">MPSTHKKDKPWDTDDIDKWKIEPFLPEHSSGPFLEESSFMTLFPKYRERYLKDCWPLVTKALEKHGIAATLDIVEGSMTVKTTRKTYDPAAILKARDLIKLLARSVPAPQALKILEDGMACDIIKIRSMVRNKERFVKRRQRLLGQNGTTLKALELLTQTYILVHGNTVSVMGGYKGLKEVRRVVEDTMNNIHPIYLIKELMIKRELAKDPALAHEDWSRYLPQFKKRTLSKRRKPFKINDKSKKPYTPFPPAPEKSKIDLQIESGEYFLSKEAKQRAAEAERAEKARQKKEEKKREREKEFVPPEEDGGKKKKRKVKHGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3W8</accession>
    <name>G0S3W8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cullin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0039150</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 12">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS22030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694326.1">
        <property type="nucleotide sequence ID" value="XM_006694263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3W8"/>
    <dbReference type="STRING" id="759272.G0S3W8"/>
    <dbReference type="GeneID" id="18257953"/>
    <dbReference type="KEGG" id="cthr:CTHT_0039150"/>
    <dbReference type="eggNOG" id="KOG2166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004747_6_1_1"/>
    <dbReference type="OMA" id="IREWDRY"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000007">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000011">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000026">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000003">
        <property type="entry name" value="Cullin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000029">
        <property type="entry name" value="Cullin homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="14" id="KW-0436">Ligase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="13">
        <location>
            <begin position="409"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS22030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="765" mass="87974" checksum="2774F68147FA065A" modified="2011-10-19" version="1">MPPPMSGLPSRPMDDIDSTWAYLQQGITRIMMNLQEGLDLQTYMGIYTAVHNFCTSQKAAGFTLTTAAVGAAQRGAHLVGEDLYRKLSDYLTEHLTALVQQSKTHTDEALLQFYIREWQRYTDAAKYIHHLFRYLNRHWVKREMDEGKKNVYDVYTLHLVRWRDVLFAQVSEKVMDAVLKLVERQRLGETIEHSQIKAVVDSFVSLGLDEGDSSKTTLEVYRYHFERPFLEATRQFYQKESKQFVAENSVVEYMKKAEARLREEEERVKLYLHPDIAIPLKKACNEVLIADHQNLLREEFQVLLDNDREEDMARMYNLLSRISDGLDPLRAKFETHVRNAGLAAVAKVASDAEKLEPKTYVDALLEVHTQYSGLVKRAFNDEPEFTRSLDNACREFVNRNEVCKAGSNKSPELLAKYTDVLLRKSGTGVEDAELESTLAQVMTVFKYIEDKDVFQKFYSRMLARRLVHSNSSSDDAEMSMISKLKEACGFEYTNKLQRMFQDMQISKDLNNGYKEHLSAVGVKGLDSTFSILGTGFWPLTPPNTSFNPPEEVNADCERFARFYKNKHEGRKLTWLWQLCKGEVKTNYIRNAKMPYIFQVSAYQMAILLLFNEKDRNTYEEIASSTALNAEALDPSLGILLKAKVLLLEGGGGKVGPGAVFALNYDFKNKKFRVNLNVGMKSETKQEEAETNKTIEEDRKLLLQSAIVRIMKARKRMKHQQLVSETINQIKSRFMPKVADIKKCIEILLDKEYLERLDDDDIGYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3X1</accession>
    <name>G0S3X1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">Postreplication repair E3 ubiquitin-protein ligase RAD18</fullName>
            <ecNumber evidence="5 18">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">RING-type E3 ubiquitin transferase RAD18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CTHT_0039180</name>
    </gene>
    <organism evidence="24">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 25">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 18">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Interacts with E2 UBC2, forming a complex with ubiquitin ligase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 18">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the RAD18 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5 18"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS22033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694329.1">
        <property type="nucleotide sequence ID" value="XM_006694266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3X1"/>
    <dbReference type="STRING" id="759272.G0S3X1"/>
    <dbReference type="GeneID" id="18257956"/>
    <dbReference type="KEGG" id="cthr:CTHT_0039180"/>
    <dbReference type="eggNOG" id="KOG0287">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028491_2_0_1"/>
    <dbReference type="OMA" id="IPNTGPR"/>
    <dbReference type="OrthoDB" id="9049620at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097505">
        <property type="term" value="C:Rad6-Rad18 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000172">
        <property type="entry name" value="E3 ubiquitin-protein ligase RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039577">
        <property type="entry name" value="Rad18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004580">
        <property type="entry name" value="Rad18_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00599">
        <property type="entry name" value="rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51908">
        <property type="entry name" value="ZF_UBZ4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17 18" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14 17 18" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13 18" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15 18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 18" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12 18" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 16 18" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="20">
        <location>
            <begin position="26"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="UBZ4-type" evidence="22">
        <location>
            <begin position="200"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="21">
        <location>
            <begin position="271"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="379"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="379"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="401"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU368093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EGS22033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="449" mass="49544" checksum="6A1FB59881465664" modified="2011-10-19" version="1">MDVPDATDWLGTPLAGLHELEQTLRCRICKDFFNSPVLTSCNHTFCSACIRRTLSVNNSRCPTCQAEDQATKLRGNWAMRDAVEAFQKHRNAILSFTRAAMAQTQPPVKAPAHLSETSTDSGSPFVEVLSPKRKSPMTLVVEDLDPKRPRLEPRASRTKALAALLSNSDSTESKEPAFHSGETHSLRAARSFAKNADDALVECPCCGQRMRESRVNQHLDKDCPVMNGSTLSASSSNTSLNFLAAPTSTSIPAALQPPKQKPPERLAPLAYSMLKDHQLRKKMADLGLPTTGSRQMLERRHQEWVTLWNANCDSARPKSRAELLRELDVWERTQGSLAPTHTRAALSGAQIKDKNFDRVGWMAKYRDMFRELTEQARASMEKAKKGAEEKKEGSAPAQSTVEERGEGLAEKTAQEIHSPQAEAPDEEASSERLPESEVVPETPAPEPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>G0S447</accession>
    <name>G0S447_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="8">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0030680</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.45"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="8"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693517.1">
        <property type="nucleotide sequence ID" value="XM_006693454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S447"/>
    <dbReference type="STRING" id="759272.G0S447"/>
    <dbReference type="GeneID" id="18257106"/>
    <dbReference type="KEGG" id="cthr:CTHT_0030680"/>
    <dbReference type="eggNOG" id="KOG0544">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2012">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002556_0_0_1"/>
    <dbReference type="OMA" id="GANLHAF"/>
    <dbReference type="OrthoDB" id="10252231at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004839">
        <property type="term" value="F:ubiquitin activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01491">
        <property type="entry name" value="Ube1_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01490">
        <property type="entry name" value="Ube1_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2660:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12550:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000015">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.180:FF:000001">
        <property type="entry name" value="ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.60:FF:000002">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000001">
        <property type="entry name" value="ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.180">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, FCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12550">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2660">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, SCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.60">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, UFD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032420">
        <property type="entry name" value="E1_4HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032418">
        <property type="entry name" value="E1_FCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042302">
        <property type="entry name" value="E1_FCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018965">
        <property type="entry name" value="Ub-activating_enz_E1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038252">
        <property type="entry name" value="UBA_E1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042063">
        <property type="entry name" value="Ubi_acti_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018075">
        <property type="entry name" value="UBQ-activ_enz_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01408">
        <property type="entry name" value="Ube1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF4">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16191">
        <property type="entry name" value="E1_4HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16190">
        <property type="entry name" value="E1_FCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09358">
        <property type="entry name" value="E1_UFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00985">
        <property type="entry name" value="UBA_e1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0697">Rotamase</keyword>
    <keyword evidence="6 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="12">
        <location>
            <begin position="19"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="927"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="9">
        <location>
            <position position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS21221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1181" mass="131015" checksum="26B950E78BA7F50B" modified="2011-10-19" version="1">MGVTKTVHVKGTGPQPLRGQKVTVAFTGWLKDTSKPDNKGRLLHSSLNYGNFEVDIGVGKVIRGWDEAVLGMKVGEQATLDITGDYAYGEQGFRGRIPPNADLILLDVIPVKIVQSGLLNESLGTLHALGKRKISEGDLPISLKRPMTERKPEEVDPVNKMQVDNSNTGAPEIDESLYSRQLYVLGHEAMKRMSASNVLVVGLRGLGVEIAKNIALAGVKSLTLYDPTPVAIADLSAQFFLRSEDVGKPRDQATAPRVAELNAYVPVRIHESPNLSENLSQFDKYQVVVLTNTPLRLQIQIGDYCHQKGIHFIVADTFGLFGSVFCDFGDNFTVYDATGENPVSGIVAGIDEEGVVSALDETRHGLEDGDYVTFSEIEGMEALNGCEPRKVTVTGPYTFSIGDVSGLGEYKRGGLFQQVKMPKFLSFKTISEAIKDPEFVISDFAKFDRPQQLHIGFQALHAFVQSKGYLPRPLNEEDAALVLELSKNIAEEQGVKVEFDEKLLKELSFQATGDLSPMAAFFGGLTAQEVLKAVSGKFHPIKQWMYFDSLESLPTSVARTEELCKPIGSRYDGQIAVFGREFQAKIANMKQFLVGAGAIGCEMLKNWAMIGLGTGPNGRVAVTDMDQIEKSNLNRQFLFRPKDVGSMKSECAAKAVTAMNPELDGHIDVYKDRVSPETEHIFHEEFWNALDGVTNALDNVEARTYVDRRCIFFHKPLLESGTLGTKGNTQVVLPNLTESYSSSQDPPEQSFPMCTIRSFPNRIEHTIAWARELFDSSFVKPAETVNLYLTQPNFLETTLKQTGNEKPTLEMLLDFLKNEKALTFEDCVQWARMQFEKHYNYNIQQLLYNFPKDAVTSTGAPFWSGPKRAPDPLKFDPNNPTHFAFIEAATNLHAFNYNINVKGKTRQDYLNALDSMIIPDFSPDANVKIQTDDKDSDPNAGGSSFDDSAELQKLINELPDPKTLAGFKLTPVEFEKDDDTNYHIDFITAASNLRAENYKIEPADRHKTKFIAGRIIPAIATTTALVTGLVILELLKIVDGKKDISQYKNGFVNLALPFFGFSEPIASPKVEYKGPGGVKVTLDKIWDRFEVGNITLQELLDDFEKRGLTISMLSSGVSLLYASFFPPAKRKDKYGMKLSELVESVTKKPIPAHQKELIFEVVTEDADGEDVEVPYIKARIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0S483</accession>
    <name>G0S483_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0031060</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693553.1">
        <property type="nucleotide sequence ID" value="XM_006693490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S483"/>
    <dbReference type="GeneID" id="18257144"/>
    <dbReference type="KEGG" id="cthr:CTHT_0031060"/>
    <dbReference type="eggNOG" id="ENOG502QUXC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_23_3_1"/>
    <dbReference type="OMA" id="GWREMFW"/>
    <dbReference type="OrthoDB" id="2105912at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17324">
        <property type="entry name" value="MFS_NepI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42910:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42910">
        <property type="entry name" value="TRANSPORTER SCO4007-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="192"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="1"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="323"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="346"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS21257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="371" mass="39959" checksum="B19CD0190AEC4326" modified="2011-10-19" version="1">MWIVLCVTESFPTFQAISFICGFTTVTPQLMLPLVGDLAPPHRRASCLSIVVSGLSLGILVARILSGVLANYTHWRNIYWFGLGVQYVVLVLLYVWMPDYPSKNPGGLNYISMLAGIVKLLVTEPSLLQAAAVAFLLSAVFTSYWTTLSFLLSSPPFGYSSMVIGLFGLIGVVVIVTAPVYSRVVIDKVVPLVSAIMGLVVELVGVIVGTFAGLHHIAGPVIEAIAIDLGSQFAQIALRSLIYSIQPLARNRVNTAYMIAAFSGQLTGTAVGNRLYALGGWEYSGSCSIAFIGFALIICFLRGPRETGWVGWSGGWPILRDDLPSRKKQPSVEAPLSGQQTPVVQRENDAKDSVVDSGHGNHEKKTDTGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G0S487</accession>
    <name>G0S487_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">18S rRNA factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0031100</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the small subunit (SSU) processome assembly and function, and in the 18S rRNA synthesis. Required for the early cleavages at sites A0, A1 and A2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF2/ABP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693557.1">
        <property type="nucleotide sequence ID" value="XM_006693494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S487"/>
    <dbReference type="SMR" id="G0S487"/>
    <dbReference type="STRING" id="759272.G0S487"/>
    <dbReference type="GeneID" id="18257148"/>
    <dbReference type="KEGG" id="cthr:CTHT_0031100"/>
    <dbReference type="eggNOG" id="KOG3152">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054086_0_1_1"/>
    <dbReference type="OMA" id="TRKHNDF"/>
    <dbReference type="OrthoDB" id="287393at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034462">
        <property type="term" value="P:small-subunit processome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12263">
        <property type="entry name" value="RRM_ABT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001147">
        <property type="entry name" value="Pre-rRNA-processing protein esf-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039119">
        <property type="entry name" value="ABT1/Esf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034353">
        <property type="entry name" value="ABT1/ESF2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311:SF7">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="125"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS21261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="343" mass="38919" checksum="E2758EE8DFEDC629" modified="2011-10-19" version="1">MPEDHKRNNFLDAGDSDSDAGNRSDSDDNFQKGGRSAKRRRVEEDESDIESDFSDNDYKEQDNNESGGANLKQDGTEPSGDDKDSEGKDKKKKDKSEKELKLPDVTKPLTKKNLVVTAEAIKKSGVIYLSRIPPFMKPQKLRSLLEPYGKINRIFLAPEDPAEHARRVRMGGNKKKMYTEGWVEFVKKKDAKKCVDLLNARTIGGKKTSWYRDDVWCMKYLKGFKWHHLTEQIAAENAERAARMRAEIAKTTKENKEFIKNVEKAKVLNGIAAKAEAKRKRLGVGEGGKEESKEDEGETQTIEGGVGFVPAKRRTFKQIPLAKKRKVDEDQPEEVKRVLSKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4E3</accession>
    <name>G0S4E3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fcf2 pre-rRNA processing C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0022510</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2017" name="Nat. Struct. Mol. Biol." volume="24" first="954" last="964">
            <title>3.2-A-resolution structure of the 90S preribosome before A1 pre-rRNA cleavage.</title>
            <authorList>
                <person name="Cheng J."/>
                <person name="Kellner N."/>
                <person name="Berninghausen O."/>
                <person name="Hurt E."/>
                <person name="Beckmann R."/>
            </authorList>
            <dbReference type="PubMed" id="28967883"/>
            <dbReference type="DOI" id="10.1038/nsmb.3476"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.20 ANGSTROMS)</scope>
    </reference>
    <reference evidence="8 9 10" key="3">
        <citation type="journal article" date="2019" name="Mol. Cell" volume="75" first="1256" last="1269.e7">
            <title>Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration.</title>
            <authorList>
                <person name="Cheng J."/>
                <person name="Bassler J."/>
                <person name="Fischer P."/>
                <person name="Lau B."/>
                <person name="Kellner N."/>
                <person name="Kunze R."/>
                <person name="Griesel S."/>
                <person name="Kallas M."/>
                <person name="Berninghausen O."/>
                <person name="Strauss D."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="31378463"/>
            <dbReference type="DOI" id="10.1016/j.molcel.2019.06.032"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.50 ANGSTROMS)</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692717.1">
        <property type="nucleotide sequence ID" value="XM_006692654.1"/>
    </dbReference>
    <dbReference type="PDB" id="5OQL">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="k=1-203"/>
    </dbReference>
    <dbReference type="PDB" id="6RXT">
        <property type="method" value="EM"/>
        <property type="resolution" value="7.00 A"/>
        <property type="chains" value="CT=1-203"/>
    </dbReference>
    <dbReference type="PDB" id="6RXU">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.50 A"/>
        <property type="chains" value="CT=1-203"/>
    </dbReference>
    <dbReference type="PDB" id="6RXV">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.00 A"/>
        <property type="chains" value="CT=1-203"/>
    </dbReference>
    <dbReference type="PDB" id="6RXX">
        <property type="method" value="EM"/>
        <property type="resolution" value="7.10 A"/>
        <property type="chains" value="CT=1-203"/>
    </dbReference>
    <dbReference type="PDB" id="6RXY">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.70 A"/>
        <property type="chains" value="CT=1-203"/>
    </dbReference>
    <dbReference type="PDB" id="6RXZ">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.40 A"/>
        <property type="chains" value="CT=1-203"/>
    </dbReference>
    <dbReference type="PDBsum" id="5OQL"/>
    <dbReference type="PDBsum" id="6RXT"/>
    <dbReference type="PDBsum" id="6RXU"/>
    <dbReference type="PDBsum" id="6RXV"/>
    <dbReference type="PDBsum" id="6RXX"/>
    <dbReference type="PDBsum" id="6RXY"/>
    <dbReference type="PDBsum" id="6RXZ"/>
    <dbReference type="AlphaFoldDB" id="G0S4E3"/>
    <dbReference type="EMDB" id="EMD-10051"/>
    <dbReference type="EMDB" id="EMD-10052"/>
    <dbReference type="EMDB" id="EMD-10053"/>
    <dbReference type="EMDB" id="EMD-10054"/>
    <dbReference type="EMDB" id="EMD-10055"/>
    <dbReference type="EMDB" id="EMD-10056"/>
    <dbReference type="EMDB" id="EMD-3847"/>
    <dbReference type="SMR" id="G0S4E3"/>
    <dbReference type="IntAct" id="G0S4E3">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S4E3"/>
    <dbReference type="GeneID" id="18256289"/>
    <dbReference type="KEGG" id="cthr:CTHT_0022510"/>
    <dbReference type="eggNOG" id="KOG3100">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075129_1_0_1"/>
    <dbReference type="OMA" id="TRGIDTH"/>
    <dbReference type="OrthoDB" id="427886at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039883">
        <property type="entry name" value="Fcf2/DNTTIP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014810">
        <property type="entry name" value="Fcf2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686:SF12">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08698">
        <property type="entry name" value="Fcf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7 8 9" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fcf2 pre-rRNA processing C-terminal" evidence="4">
        <location>
            <begin position="86"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS20421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="5OQL"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="6RXT"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="6RXU"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="6RXV"/>
        </source>
    </evidence>
    <sequence length="203" mass="22526" checksum="201A7F1E930DC098" modified="2011-10-19" version="1">MATTLGLPDEEIDRLLAEAEARLAGSGDADAGAIALAKPAASKPLTVAAPAAPKAGEQTVPQVKKAEELSVRVPQLPQKKKGPPDTLSDWYNIPRTNLTPELKRDLQLLRMRDVVAMGKQFFKKDNRKDFVPEYCQVGTIIAGATDGVSGRLTRKERKRTIVEEVLSSDSVSKYKRKYHEIQEHKKSGRKGYYKKLMAARKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4G1</accession>
    <name>G0S4G1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="19">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CTHT_0022690</name>
    </gene>
    <organism evidence="23">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">NADH-dependent reductase for DPH3 and cytochrome b5. Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1. By reducing DPH3, also involved in the formation of the tRNA wobble base modification mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), mediated by the elongator complex. The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>2 Fe(3+)-[Dph3] + NADH = 2 Fe(2+)-[Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71231"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:71232"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 19">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18 19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Monomer. Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="19"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692735.1">
        <property type="nucleotide sequence ID" value="XM_006692672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4G1"/>
    <dbReference type="STRING" id="759272.G0S4G1"/>
    <dbReference type="GeneID" id="18256307"/>
    <dbReference type="KEGG" id="cthr:CTHT_0022690"/>
    <dbReference type="eggNOG" id="KOG0534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_9_0_1"/>
    <dbReference type="OMA" id="VQIFMCG"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000032">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000019">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF184">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 18 19" id="KW-0274">FAD</keyword>
    <keyword evidence="5 18 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="11 19" id="KW-0520">NAD</keyword>
    <keyword evidence="10 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="21">
        <location>
            <begin position="61"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EGS20439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="310" mass="33964" checksum="B51132B4AD1F0856" modified="2011-10-19" version="1">MASESLLARKYFDGIYIPLGLIVLGTAIIKTEWTHYALLVGIVLGGIKYYRMTPKKVLKPDAFQEFELIEKTILSHNVAIYRFKLPSPTSILGLPIGQHISIAADIKQPDGTTKEIVRSYTPISGDEQPGSFDLLIKSYPQGNISKHIASLSIGQTIRVRGPKGAFVYTPNMVRAFGMIAGGTGITPMLQIIKAIIRGRKDGDRTEVDLIFANVTEQDILLKEDLDALAAKDKGFRVHYVLDKPPAGWTGGVGYVTAEMIQKWLPKPADDVKILLCGPPPMVSGLKKATEGLGFKKARPVSKLEDQVFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5N3</accession>
    <name>G0S5N3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Pre-mRNA-splicing factor SYF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0024880</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="13 14 15" key="2">
        <citation type="journal article" date="2025" name="Cell Res." volume="35" first="296" last="308">
            <title>Structural insights into spliceosome fidelity: DHX35-GPATCH1- mediated rejection of aberrant splicing substrates.</title>
            <authorList>
                <person name="Li Y."/>
                <person name="Fischer P."/>
                <person name="Wang M."/>
                <person name="Zhou Q."/>
                <person name="Song A."/>
                <person name="Yuan R."/>
                <person name="Meng W."/>
                <person name="Chen F.X."/>
                <person name="Luhrmann R."/>
                <person name="Lau B."/>
                <person name="Hurt E."/>
                <person name="Cheng J."/>
            </authorList>
            <dbReference type="PubMed" id="40016598"/>
            <dbReference type="DOI" id="10.1038/s41422-025-01084-w"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.80 ANGSTROMS)</scope>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">May be part of a spliceosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SYF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692948.1">
        <property type="nucleotide sequence ID" value="XM_006692885.1"/>
    </dbReference>
    <dbReference type="PDB" id="9L5R">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="B=1-326"/>
    </dbReference>
    <dbReference type="PDB" id="9L5S">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="B=1-326"/>
    </dbReference>
    <dbReference type="PDB" id="9L5T">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.50 A"/>
        <property type="chains" value="B=1-326"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5N3"/>
    <dbReference type="EMDB" id="EMD-62841"/>
    <dbReference type="EMDB" id="EMD-62842"/>
    <dbReference type="EMDB" id="EMD-62843"/>
    <dbReference type="SMR" id="G0S5N3"/>
    <dbReference type="STRING" id="759272.G0S5N3"/>
    <dbReference type="GeneID" id="18256526"/>
    <dbReference type="KEGG" id="cthr:CTHT_0024880"/>
    <dbReference type="eggNOG" id="KOG2609">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051065_0_1_1"/>
    <dbReference type="OMA" id="RRRMHND"/>
    <dbReference type="OrthoDB" id="199717at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013260">
        <property type="entry name" value="mRNA_splic_SYF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264">
        <property type="entry name" value="GCIP-INTERACTING PROTEIN P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08231">
        <property type="entry name" value="SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="13 14 15" id="KW-0002">3D-structure</keyword>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS20652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="9L5R"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="9L5S"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="9L5T"/>
        </source>
    </evidence>
    <sequence length="326" mass="36881" checksum="1B54511332885D2E" modified="2011-10-19" version="1">MPPAKKRKTEASQEPRPASEQQEQNGAQEEQPTVQDSTPEVESRSDDKKVSQSPTLATDPSDDTSEQPSESSTKNAALTAAQERLARFRALQARAKESSQQNLKEATKESQRLATDPSQLTALSRKHAIAAHKLLKAEIEDAGGDFERKRAWDWTVEEAERWDKRMKKKEAHRDDTAFRDYAREAEKTYKRQIRNMGAPDLEKYMREKLSAIEKAAAAGTLDIIETEDGEMIAVDKDGTFFSTANATDFAQHKPDKAAVDRLVADLRKAEEASLKRRREKLAKSGEEHGDVTYINEKNKQFNAKLARFYNKYTAEIRDSFERGTMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5N9</accession>
    <name>G0S5N9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0024940</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692954.1">
        <property type="nucleotide sequence ID" value="XM_006692891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5N9"/>
    <dbReference type="STRING" id="759272.G0S5N9"/>
    <dbReference type="GeneID" id="18256532"/>
    <dbReference type="KEGG" id="cthr:CTHT_0024940"/>
    <dbReference type="eggNOG" id="KOG1569">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062853_1_0_1"/>
    <dbReference type="OMA" id="EFRVDKH"/>
    <dbReference type="OrthoDB" id="1747252at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS20658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="290" mass="31920" checksum="4C6EA4FB0E8B1646" modified="2011-10-19" version="1">MASLNQCLASLARLSLSAPARPILASTIPKFLAPATATPIAHYATVIKRAQKKKKNYKTYKCWDLSEMEQYLRAFEVGNPPHVSKYELHVKLRTGKGGPVLRNRIRFPHPVKSDARIGVICPENSPLAAEALAAGAVAVGQETLFERIRQGDIPFNKLICHVNSEAALKKANLGRILGPKGMMPNHKTKTITRNIRETVEELIGADEYRERTGVVRIAVGQLGFTPQMLSDNIKAFMSLLKQDLANCDDNHPKSLDEVVLSSTHGPGFSLDGTFFSKDENLKPEHLTSAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5Z1</accession>
    <name>G0S5Z1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0025430</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the pacC/RIM101 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693003.1">
        <property type="nucleotide sequence ID" value="XM_006692940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5Z1"/>
    <dbReference type="STRING" id="759272.G0S5Z1"/>
    <dbReference type="GeneID" id="18256581"/>
    <dbReference type="KEGG" id="cthr:CTHT_0025430"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012842_1_1_1"/>
    <dbReference type="OMA" id="QWGNCRT"/>
    <dbReference type="OrthoDB" id="6155966at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000458">
        <property type="entry name" value="pH-response transcription factor pacC/RIM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001875">
        <property type="entry name" value="pH-response transcription factor pacC/RIM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050806">
        <property type="entry name" value="pacC/RIM101"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47257">
        <property type="entry name" value="PH-RESPONSE TRANSCRIPTION FACTOR PACC/RIM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47257:SF1">
        <property type="entry name" value="PH-RESPONSE TRANSCRIPTION FACTOR PACC_RIM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="161"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="197"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="322"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="466"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="512"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="596"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="664"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="97"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="478"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="514"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="532"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="683"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS20707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="715" mass="74767" checksum="233F2423795BFE18" modified="2011-10-19" version="1">MSATSPTQQQAQQALASPALASPTQAAAVAATTTPTAANAAAVTSPQQAPQQQSDAAAAAAGNTTTSANNTNTAATNTNNNNNNNNNNGNGNGNGNGNSAQQTTQGQAQAQATAQAPATGTTSAQNQSAPATNAASADSNTPAPTSATPQSATSTTAEVPLICKWNECNEPFATAEALYEHLCEKHVGRKSTNNLNLTCQWNQCRTTTVKRDHITSHIRVHVPLKPHKCDFCGKAFKRPQDLKKHVKTHADDSVLVGPRTAQDPQGLNANYRATPRAPPSMYDQHGHMRGANQGHFAAPPQNGQPNYYQPPAPPHPSYHPSMYGYQQPPPMGGGAPRPDYLSHQAAAAPAPSPSFGEVRRRGMDDLNEFFGALKRRQIDPTSYQQIGRSLMPLHASLGFSAGGGLAAEYMPQPPHTLGVAGSHGPLTQHYYLPPMPNLRTKEDLQQIDHILEQMQATVYETAGSPAAQYPPVDLRHSPTAYAPRGPAPAAAAAANPADQYAVSAAQVVSPLTAPASSTGGTPAVTPPSSTISYASAHSPTASSSGMSPSSRHNSTSAPVSYPSLPSRPGLPYPTATALGSNFAHNERRLSGGMLQSASSIARRDSDRTPTPKGVAAAADGTAVSSPSDASEHGTETDSYEGTQLYRLIEALRISIRQRLQRGEYEVDSDSNQMQIDPALHGNQADNVGNADDSTNINGNGSAREDRVSYPSLPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6C5</accession>
    <name>G0S6C5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0034420</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693876.1">
        <property type="nucleotide sequence ID" value="XM_006693813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6C5"/>
    <dbReference type="STRING" id="759272.G0S6C5"/>
    <dbReference type="GeneID" id="18257480"/>
    <dbReference type="KEGG" id="cthr:CTHT_0034420"/>
    <dbReference type="eggNOG" id="ENOG502RV5I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009988_1_0_1"/>
    <dbReference type="OMA" id="WIPSYSY"/>
    <dbReference type="OrthoDB" id="5233646at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47965">
        <property type="entry name" value="ASPARTYL PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47965:SF101">
        <property type="entry name" value="HYPOTHETICAL ASPARTYL PROTEASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408949" description="Peptidase A1 domain-containing protein" evidence="4">
        <location>
            <begin position="27"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="5">
        <location>
            <begin position="65"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="452"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="510"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="551"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="655"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="808"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="863"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="457"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="513"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="558"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="676"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="748"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="821"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="864"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="876"/>
            <end position="914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS21580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="937" mass="102051" checksum="2F632B1CDF847EDD" modified="2011-10-19" version="1">MPLPARGLAISCFALQLLSALQPVTASADAGTGADGGADKPPSKSPEPLWIQPSGEWYGIDGDWSNFAFFIGSPAQAVYLTPATALSEIWVVSTGGCVPVQLCIDARGGVFDISQSDTWRSLGTWLLGMNYTGMGGNGDYGLETLAFVNTVASFTTAIDDALVAVYNDTNYYQGYVGLGVTQGRFGNNLTMPFISQLAQSYGSIPSHSYGYTAGAYYRPNGKNRGTVASLTLGGYDKLRFVPHDHKFALDPVTRLPTVRLRGITAHVDSIEHAPTKNWTSTSHPLVTMDDSIIAIIDSSTPYLWLPTPVCERFAAALNLTWREDLGVYVFANGAQYTHYQNDESLKFTFTLSSYQNADDFGQPLSTPGVVNITLPSAAFAQLLRYPFRNVIKWGDSSIPYFPLKRSTKEVNNEQYIIGRVFMQEAYLITSYDRSSFSLHQALFPQNASSNYSLEAIPRPPDSPYPPYRNEPTSPSLKGGLNTAQKAGIALGILITLGLLSLFLYFRHQHKRPSKENKDTAGAESERTEVPAALQEEVPTSPVKRMFTKVVNKKRSRKTVTAGSDGSSGQPVEVGADAQHQVYEMPVPPEPVELDSNDVGDDITELGLDTTQGLSQYEITRRKLERQMRGPVPAYTPPENGMAINIQEKSAQDISPIPHYRPADEPSPASSPTYANSSTLPYSLPSPLTPHGEWTSRMTDLPSPMTIAPPTRFPGPSSEQEAGISLSPGPSPVTPRSVHFPPSMAPTPITCSGSNPAPTTPTSGTMPRLGPPVQRTPIDPSRVVCLGPLPENIQLQLPQQPVPRLRIPQSPLADLSSPGVGPSQSLGHYRSDTQGSTDTLGSNYTMEEAERLKELERQHGLIMARSSQVQEQGENSSRQRETGEQKMSEGQIEHRSASSDTRESRSPNSEERIETGFEIIHVPQMAEKRYSFEVGDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6F1</accession>
    <name>G0S6F1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0034690</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693902.1">
        <property type="nucleotide sequence ID" value="XM_006693839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6F1"/>
    <dbReference type="STRING" id="759272.G0S6F1"/>
    <dbReference type="GeneID" id="18257507"/>
    <dbReference type="KEGG" id="cthr:CTHT_0034690"/>
    <dbReference type="eggNOG" id="KOG1657">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045277_7_3_1"/>
    <dbReference type="OMA" id="PYNTNAI"/>
    <dbReference type="OrthoDB" id="636685at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23645">
        <property type="entry name" value="HFD_Dpb3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF54">
        <property type="entry name" value="CHROMATIN ACCESSIBILITY COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="4">
        <location>
            <begin position="19"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="130"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS21606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="190" mass="20884" checksum="9D0750E336F8738C" modified="2011-10-19" version="1">MPYNTTAIPPRKEVTGQTLLPLTRVKKIIAVDPDINVCSNNAAFVITLAAEMFVQYLAAEAQNMTKLDRKPRRNIQYKDLANAVAAHDNLEFLEDIIPKTVPYKDIKIKAAATRAKLATEKMDGMAAAVDDRSTDGMSNGKKHKSIINGTTNGYSRSHVFSPDASDPSAQLQREMRQAQHSHDGDVDMTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6J5</accession>
    <name>G0S6J5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Carboxypeptidase</fullName>
            <ecNumber evidence="13">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0026440</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Release of a C-terminal amino acid with broad specificity.</text>
            <dbReference type="EC" id="3.4.16.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="13"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693102.1">
        <property type="nucleotide sequence ID" value="XM_006693039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6J5"/>
    <dbReference type="STRING" id="759272.G0S6J5"/>
    <dbReference type="MEROPS" id="S10.001"/>
    <dbReference type="GeneID" id="18256682"/>
    <dbReference type="KEGG" id="cthr:CTHT_0026440"/>
    <dbReference type="eggNOG" id="KOG1282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008523_10_4_1"/>
    <dbReference type="OMA" id="GDWMKPF"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.410:FF:000001">
        <property type="entry name" value="Carboxypeptidase Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008442">
        <property type="entry name" value="Propeptide_carboxypepY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05388">
        <property type="entry name" value="Carbpep_Y_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13 15" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Propeptide carboxypeptidase Y" evidence="14">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF05388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS20806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="554" mass="61732" checksum="275AE5ADC2675889" modified="2011-10-19" version="1">MKIAASTVLLGAASAASFQQHAQHVLSNGLNKVQEAAKPISDAFVDATSIPVEKLEDLFGSASAEAKALWEEIKLLVPESAFQQGSWFSKPKPHRRRDDWDHIVRGADVQKLWVQDADGESHRQVDGRLENFNLRVKAVNPSKLGIDTVKQYSGYLDDEANDKHLFYWFFESRNDPKNDPVVLWLNGGPGCSSLTGLFLELGPSSIDKKLKPVYNEFSWNNNASVIFLDQPVNVGYSYSGSSVSNTVAAAKDVYALLTLFFHQFPEYATQDFHIAGESYAGHYIPVFASEILSHKNRNINLKSILIGNGLTDGLTQYAYYRPMACGDGGYPAVLSESECRSMDNALPRCQALIKSCYESGSVWTCVPASIYCNNALIGPYQRTGRNVYDIRGNCEDSGNLCYSALGWISDYLNQKSVMQALGVEVDGYDSCNFDINRNFLFAGDWMQPYHRLVPNILKEIPVLIYAGDADYICNWLGNKAWTEALDWSGKKSFNEAELEDLKLPGANEAYGKVKASGNFTFMRIYQAGHMTPMDQPEASLDFLNRWLGGEWFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6P7</accession>
    <name>G0S6P7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0035140</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693945.1">
        <property type="nucleotide sequence ID" value="XM_006693882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6P7"/>
    <dbReference type="STRING" id="759272.G0S6P7"/>
    <dbReference type="GeneID" id="18257552"/>
    <dbReference type="KEGG" id="cthr:CTHT_0035140"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1107001_0_0_1"/>
    <dbReference type="OMA" id="YWARADE"/>
    <dbReference type="OrthoDB" id="10029320at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS21649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="28488" checksum="527820A605B893AC" modified="2011-10-19" version="1">MDVIWTCRPNSWQSSSNPLRPPLMWWRSRIIREYFLPIVEEVVAQAADKVNSSEGPDVKTALFLATKGYVAAEREELANTRFSFRLDKDFISKIIPHFTIFILVGHGTTAATLGFIYYLLRINPSKLSALWAEYDAVLGPDPNRAASLIAANPTVFNSLPGQPGFDLIDPADFTKRYPTDGFEVHGDMWSARHFEHIFPRAAELLPKRFLPPESDPLHVRKKAFRPFSTGLRSCIRQELGTMKIRMILAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6Y8</accession>
    <name>G0S6Y8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Helicase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0035520</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693982.1">
        <property type="nucleotide sequence ID" value="XM_006693919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6Y8"/>
    <dbReference type="STRING" id="759272.G0S6Y8"/>
    <dbReference type="GeneID" id="18257590"/>
    <dbReference type="KEGG" id="cthr:CTHT_0035520"/>
    <dbReference type="eggNOG" id="KOG0385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_17_3_1"/>
    <dbReference type="OMA" id="PNIFTDW"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000015">
        <property type="entry name" value="lymphoid-specific helicase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001315">
        <property type="entry name" value="SNF2 family helicase/ATPase PasG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="161"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="670"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="438"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="500"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="591"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="473"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="504"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="573"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="597"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS21686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="903" mass="102253" checksum="06B46F4509884E47" modified="2011-10-19" version="1">MPHLEYSEDDTTASTSSLSRLPTSAPSSPPPTSPDKKTMDMDKPKMTYTKLREEQILAEEEEKARIANLKAEEKRKRKVWRKRILTKEEREAKAKDLDRLLAQSAAFSSILTNKTKVLGRVGTSLDGKTLGEHDLVMAKQPKCMVGGTMRDYQLEGLTWMYEICIQGMSGILADEMGLGKTVQAISLIALLREQENYLGPHLIVAPLSTLSNWLDEFHHWVPSIPVVMYHGTPQQRTEIFKTKIMRNLKNGRPTEQFPVVCTSYEMVLKDRASLSKINWEFIIIDEGHRMKNFDSKLFRELKSFSSATRLLITGTPLQNNLKELWSLLNFLLPKIFRDWEAFESWFDFSDLEDEEGTEEFIADKTKQELVKKMHIVLQPLLLRRVKADVAKYLPKKREYVLYAPMTKEQTDLYNVINDKNIDTRAYLENKVIERLTSAAANSKASSPKRSTRQSRAGSVKQESDNNSEPTSDTAHDARSSAKKAEEIPPAKNAFALLMGKARHQSQTAKDAASASTKKADSLPSQSNKNTIKRKIPPTSEEPARKTAKASKEATPTSARGRPRRGRHSYKEADSDEELLDGDEFEEKLAKELTHGEETEEEQTAEDEEEIERMQTLELAKREIASKKLGNPLLQLRLVCNSPHNFYNPWSVDNGLPVDESIVTASGKMLLLDRLLPELFKRGHKVLIFSQFKTQLDILQDYCTELRKWPVCRIDGGVSQEERRAQIREFNSNPDLKIFLLSTRAGGQGINLASADTVILFDSDWNPQQDLQAQDRAHRIGQTRPVIVYRFATKGTVEEELLMSADAKRRLEKLVIKKGGFRTMGQKIDLKEELDRETLRTLLLKDGQVYKFSGDKEILSDHDLEVLCDRSDEAYERAAAGAGNADAYKVIETGAEGIVHAGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0S795</accession>
    <name>G0S795_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0036060</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694035.1">
        <property type="nucleotide sequence ID" value="XM_006693972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S795"/>
    <dbReference type="STRING" id="759272.G0S795"/>
    <dbReference type="GeneID" id="18257644"/>
    <dbReference type="KEGG" id="cthr:CTHT_0036060"/>
    <dbReference type="eggNOG" id="KOG2318">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010564_0_1_1"/>
    <dbReference type="OMA" id="DHDFAID"/>
    <dbReference type="OrthoDB" id="431825at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039754">
        <property type="entry name" value="Esf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056750">
        <property type="entry name" value="RRM_ESF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202:SF0">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25121">
        <property type="entry name" value="RRM_ESF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ESF1 RRM" evidence="7">
        <location>
            <begin position="173"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="NUC153" evidence="6">
        <location>
            <begin position="629"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="69"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="111"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="219"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="404"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="518"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="597"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="644"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="247"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="419"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="601"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="611"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="678"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS21739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="711" mass="80617" checksum="0FD42F0D4F1D871F" modified="2011-10-19" version="1">MPKSKAKSDKKDGTASRITDPRFANFETDPRYQLPSKKKLKTKLDSRFSKVLKDEDFISTAKVDRYGRKLKSDSKKKALQRLYEGEDEDDLPKLESDVEVDDDDIVRRELAKADKKYDPARDGGFSSSESDSDSSDSDSESSSEVAEDDEEEETRPGIRLRRDKEVVEEGEVTRRFAVVNMDWDHIKSVDLMALFTSFLPPGGRIEKVSIYPSEFGKERMQREDLEGPPKEIFKKSKASDDSSSSDSDSDSDSSSSTDEDSDEEVKKELLKEGDDQDFDSDALRAYQLERLRYYYAVVVCSDKDTAHKLYEATDGTEYLSSSNFLDLRFIPDDVTFDDEPRDECDSVPAGYKPIEFVTDALQHSKVKLTWDMHPEELARKETIRKAFTGSRADLAENDLRAYLASDTDSDDEDIGPSADGKDNEEAKLSKKELARRKLRAALGLPDDPIESLKPSKDGPVGEMQITFTPALSEKPQKEDVEETTIEKYKRKERERKEKRKLKALAKKQGVDLETLLEEKKKAEEPVEDLGFDDPFFTTEPTLPSKSALRKQEKQKKRAAREKEEAEDATQRAQLELLMADENGDGAHLDHFDMKEIMRAEKKGKKKKKGKKGEEDRGGLQEDFKMDVDDPRFKAVFESHEFAIDPSNPKFKATTGMKKLLEEGRKKRKAAPEDIPGVGKEDRSSKKAKQDDLSELSSLVNAVKKKVKANKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7F9</accession>
    <name>G0S7F9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0028000</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693257.1">
        <property type="nucleotide sequence ID" value="XM_006693194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7F9"/>
    <dbReference type="SMR" id="G0S7F9"/>
    <dbReference type="STRING" id="759272.G0S7F9"/>
    <dbReference type="GeneID" id="18256838"/>
    <dbReference type="KEGG" id="cthr:CTHT_0028000"/>
    <dbReference type="eggNOG" id="KOG4203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067096_1_1_1"/>
    <dbReference type="OMA" id="KHKIGLM"/>
    <dbReference type="OrthoDB" id="106623at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008655">
        <property type="term" value="P:pyrimidine-containing compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000023">
        <property type="entry name" value="Probable uracil phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="11">
        <location>
            <begin position="37"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS20961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="224" mass="24734" checksum="32C6973A2CD5C188" modified="2011-10-19" version="1">MSDTKSSVGPDYQHESQKPTATVSTPVEGVGSLIVLPQTPQLIALLSIIRNKDTNRGDFIFYANRIIRLLVEEGLNHLPTVEHTVTTPVGRTYDGLAFQGKICGVSIMRAGEAMEQGLRECCRSVRIGKILIQRDEETAQPKLFYDKLPDDIANRWVLLLDPMLATGGSAIMAVDVLKSRGVPEERILFLNVLASPQGVRNFASKYPKVRIVTAFVDEGLNEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7L3</accession>
    <name>G0S7L3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0036730</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694100.1">
        <property type="nucleotide sequence ID" value="XM_006694037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7L3"/>
    <dbReference type="GeneID" id="18257711"/>
    <dbReference type="KEGG" id="cthr:CTHT_0036730"/>
    <dbReference type="eggNOG" id="ENOG502SG05">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150138_1_0_1"/>
    <dbReference type="OMA" id="ENMGGEK"/>
    <dbReference type="OrthoDB" id="5278621at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="85" mass="8740" checksum="48C9506C8F6AA51E" modified="2011-10-19" version="1">MNPSNTSGAQKTPANANVGEDKPKMFDEHGTIGKQFTPEGAIGGTAQKIGGPLDKEGMIGKQFTTEGSIGGTVQNMMGGTKKKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0S846</accession>
    <name>G0S846_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription initiation factor IIF subunit alpha-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0029340</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIF alpha subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693389.1">
        <property type="nucleotide sequence ID" value="XM_006693326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S846"/>
    <dbReference type="STRING" id="759272.G0S846"/>
    <dbReference type="GeneID" id="18256972"/>
    <dbReference type="KEGG" id="cthr:CTHT_0029340"/>
    <dbReference type="eggNOG" id="KOG2393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025955_0_0_1"/>
    <dbReference type="OMA" id="IPIMTTK"/>
    <dbReference type="OrthoDB" id="76676at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001096">
        <property type="term" value="F:TFIIF-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008851">
        <property type="entry name" value="TFIIF-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011">
        <property type="entry name" value="TFIIF-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="203"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="334"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="452"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="366"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="470"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="490"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="515"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="583"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="646"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS21093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="758" mass="84700" checksum="507F8C67F39EC171" modified="2011-10-19" version="1">MSAPPPQGPPPAARPPGPPRPPGSGPPPSMQFHRKGVFNPLVARKKPRPKPACALPPKDHKALMELNASQAAHKFDELLGPENEAALKRLQEERARNGGWSETPDNCQEFPLVMTKRSMLEGLRYHIMRLNKKTDEDIDVTNQEQFPRPVTLLRRDPRLPPAHKMNQTKAEEQTPRDPAEAAELERIRQLKAEREAQRAADLAQIAPVLRNNEPKQKQNNNKKEKPTAFYGRDTEAQKKESRIHYEETWPWHLEDAEGKAGVWVGSYVSNLSDLHVALVIDGNRFRMIPLERYYRFDEKPKFETLSLDDAEKMMYEVKEIKRWVMKQKEQEALEREKNETRQFLRGPVRVKTESATSRAARRDERADDYELDMSGDEFQDDDENPGFDADDEETKETKNRLRREHIQANTFGEGDDQKVEQEEREEQLERLRRKMLGKQTLKTLKKFEHAMDFEDMESDDENNPFTDHEDSSDEESEDKEDEDSKKEPSGANTKGNVTPSSKQRVDTKKAPNAASNNNNNNNNNNNNNNNNNNNNNSNNNNNNNNNNSSSSSNNNNNKLKRPGSAHLSESSDNENARKKIKTGTKTAPATTLPSRGATPIPGRPKNPQASAMSDGEATAGEISDAGSKLKPKLKVKPGVRPGGTPAGSRSGSPAPSGAPKPSTGTTPTPQQPAQAQASSQSQQPQAAAAAVPPAPDRIQPADIAAALAPYAKEGISLGNLLRKFKDRIDKPGHISRSEWIQMVKQTAVYGPDKLLRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8D1</accession>
    <name>G0S8D1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10 13">Catalase</fullName>
            <ecNumber evidence="3 10 13">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CTHT_0021320</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 13">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 13">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="3 10 13"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692602.1">
        <property type="nucleotide sequence ID" value="XM_006692539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8D1"/>
    <dbReference type="STRING" id="759272.G0S8D1"/>
    <dbReference type="PeroxiBase" id="14257">
        <property type="entry name" value="CtheKat01"/>
    </dbReference>
    <dbReference type="GeneID" id="18256170"/>
    <dbReference type="KEGG" id="cthr:CTHT_0021320"/>
    <dbReference type="eggNOG" id="KOG0047">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010645_3_0_1"/>
    <dbReference type="OMA" id="WQMSDRA"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03132">
        <property type="entry name" value="GATase1_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000003">
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        <property type="entry name" value="Catalase_clade2"/>
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        <property type="entry name" value="Class_I_gatase-like"/>
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        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
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        <property type="entry name" value="Heme-dependent catalase-like"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 10 13" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 10 13" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="16">
        <location>
            <begin position="80"/>
            <end position="470"/>
        </location>
    </feature>
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        <location>
            <begin position="556"/>
            <end position="588"/>
        </location>
    </feature>
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        <location>
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        </location>
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    <feature type="active site" evidence="11">
        <location>
            <position position="203"/>
        </location>
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    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGS20306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="776" mass="86846" checksum="F5E5A3EE3E9E91BD" modified="2011-10-19" version="1">MKPLATNMQQGTLPRNFLSMNLKDGRYKQKPREKFNRPMAGIMSDTMERAKQAVLGPRESDKLHDLAKVTKDISPDHRLTTDYGVKQTTHDDWLKVASSDKTGPLLLEDPLGREKIMRFDHERIPERVVHARGSGAFGKFKLLEPIPELTMAGVLTDTSRETPVFVRFSTVLGSRGSADTVRDVRGFATKFYTKEGNWDIVGNNIPVFFIQDAIKFPDVIHAGKPEPHNEVPQAQSAHNNFWDFQFNHTEATHMFMWTMSDRAIPRSFRMMQGFGVNTFTLINSKGERHFAKFHWTPELGVHSLVWDEALKISGQDPDFHRKDLWEAIANGVYPKWKFGIQVIPEADENKFDFDILDATKVWPEDLVPVRYIGEMELNRNPDEFFTQVEQIAFCTSHVVPGIGFSDDPLLQGRNFSYFDTQISRLGVNFQELPINRPVCPVMNFNRDGALRHTITRGTVNYWPNRYGAVPPATLDEGGYLEYAERVAGIKARMRSAKFKDHFSQAQLFYNSLSPIEKAHLTNALAFELDHCEDPLVYSRMAQRLADIDFSLAKEVHSRIGGDPPSETNRRPNHGKKAPNLSQFDFPPSNPTIASRRVAILVGDGYDHYAFSSAYAALTTAQAVPLVVGTKRSRLRAANDAGSTEPHHHLEGLRSTLVDALFIPGGTESIATLACSGRALHWIREAFGHLKVIGATGEAVSLVQSAIGLPEVKVSGGGEVVECLGVVTVREVTAGSLKEAVDLVKGGDGFMERFFEGVAAHRCWERESQGLSIRIAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8E1</accession>
    <name>G0S8E1_CHATD</name>
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        <submittedName>
            <fullName evidence="1">Phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0029560</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006693348.1"/>
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    <dbReference type="STRING" id="759272.G0S8E1"/>
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    <dbReference type="KEGG" id="cthr:CTHT_0029560"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059493_0_0_1"/>
    <dbReference type="OMA" id="RHHTIDP"/>
    <dbReference type="OrthoDB" id="1065058at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="SDT1p Pyrimidine nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.450">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
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        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052791">
        <property type="entry name" value="SSM1_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438:SF1">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS21115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="217" mass="25311" checksum="F2E03E7A69C6B5FE" modified="2011-10-19" version="1">MGSADSDHPLTNRVEPKQVLFFDIDNCLYPKSARVHDLMKDLIDRYFHEHLSLPWEEAVRLHREYYQSYGLAIEGLVRHHQIDPLEYNAKVDDALPLDGVIKPRDELKKLLRDIDRSKVKLWLLTNAQVPLVCKPQRGMYEKAMREAGVERFEDCYFVDDSYLNCQKAEEIGWNVAHLVEDGVKVPDTPACKYQIRHLDDLRTVFPQFFKPESIAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8G7</accession>
    <name>G0S8G7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rab GTPase activator-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0029820</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693437.1">
        <property type="nucleotide sequence ID" value="XM_006693374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8G7"/>
    <dbReference type="STRING" id="759272.G0S8G7"/>
    <dbReference type="GeneID" id="18257020"/>
    <dbReference type="KEGG" id="cthr:CTHT_0029820"/>
    <dbReference type="eggNOG" id="KOG2595">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039465_0_1_1"/>
    <dbReference type="OMA" id="VYMFAQI"/>
    <dbReference type="OrthoDB" id="206700at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045913">
        <property type="entry name" value="TBC20/Gyp8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913:SF7">
        <property type="entry name" value="RE60063P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 20/GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="4">
        <location>
            <begin position="74"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS21141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="472" mass="52873" checksum="C276ED7B4DA69E6E" modified="2011-10-19" version="1">MDEPADDIKSIASEMEEDQKLPEPIPAGLDEKGPNQDAHADGGGVEDKKQAILHACRTRDLARLRALAESPGGFLSDDLRQQAWPVLLGLPPFGTDVKAEDDGRDGHNGYSSTTSSAFSWESLPRHKDEDQVQLDVNRAFVYYPKNQTDSQRQHQKSLLSDLILSVLRRHPYLHYFQGYHDIAQVLLLVLNPPISTPNTSLPQTSILLSHLSLLHIRDFMLPSMTPSLAQLHLIPDILRHADPLLYRLLSLTEPFFALAGTLTMYAHEVPTFSEITRLFDVLLARDPCFTAYLFASLILARRDELLSVEPDRDILHAVLSRLPDPLPVPIETLIANAAALERKYPPETLPSWKKRVSKWSVLKTARRKPGMEGIPPGSIEDAQQYFEKQVRELEWLEKRDRARKWVWQHRRSVGMAGMAVVVAVLAVLLRRAGENVPSGTWASVYLGYPGVLPGSVAEGMAWLSGVLRGLWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8J5</accession>
    <name>G0S8J5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0038310</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694251.1">
        <property type="nucleotide sequence ID" value="XM_006694188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8J5"/>
    <dbReference type="GeneID" id="18257869"/>
    <dbReference type="KEGG" id="cthr:CTHT_0038310"/>
    <dbReference type="eggNOG" id="ENOG502S2DU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021934_0_0_1"/>
    <dbReference type="OrthoDB" id="3853857at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001727">
        <property type="term" value="F:lipid kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF108">
        <property type="entry name" value="DAGKC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="2">
        <location>
            <begin position="185"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS21955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="578" mass="62652" checksum="72B1A48494272665" modified="2011-10-19" version="1">MSRLSKLVSRAFMRKRSKRQQQPSRADPSSPERESNDEMFISVDAPRFSTFHTPSSIGNGRLPLSTPSFDALGAISENEVVCILPPAAAKSSSEPYYTVYTLTESPVDHASGDGPSARKGPFTLQALHVPADQAPAYSSLLGQYLLTGEKAQRASLLSDDVEVDVIISTRSGLGLAREFYESVLKEILEALGRPLLEDEGKGGSKGHRITVTKDGNTIKEFAQGLGKAAADSTVKNKLVLLLSGDGGVVDMLNGLETSWLSQQSAKQAGEREQMTLSSPAVALLPLGTANALFHSLHKSLHQQAGSNGPSPLVLSLRTLLFGVPAALPTFRTEFSPGARLVAGPSEPTHAPTTAEDMHSSAAGTVQVGHLLGAIVASYGFHASLVWESDTPAYRKHGDKRFGMAAAELLREAHGYDAVVDIRRQQQLDTESIRLYHGAVADHRCSYVLTTLVSNLERTFTISPRGKPLDGQLRLVHFGDVGGDRTMEIMQAAYREGEHIGMQDVGYEPPAEDGTLEEVTVTVNEDDPRWRKVCVDGTIVELEQGGWMRVRREKGQWLRILVDRCVAEQTEKLRNAIGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2024-01-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8P4</accession>
    <name>G0S8P4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0039860</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988042">
        <property type="protein sequence ID" value="EGS20247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694396.1">
        <property type="nucleotide sequence ID" value="XM_006694333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8P4"/>
    <dbReference type="STRING" id="759272.G0S8P4"/>
    <dbReference type="GeneID" id="18258024"/>
    <dbReference type="KEGG" id="cthr:CTHT_0039860"/>
    <dbReference type="eggNOG" id="ENOG502RS39">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1023080_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408907" evidence="1">
        <location>
            <begin position="17"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="272" mass="29530" checksum="81FCCF478A84C29A" modified="2011-10-19" version="1">MKFFTALAAFVGLAAARAVDRVERRHCDAVTSWSTSYTTITLPPVTSYTTITLPGVTETSYTTIATTLATTQTIDVPVPTQTVTVPGGTTVVTDITVIIATLVKTVTEVETLIRADLKIIANILAAAKIDIDALVKVVVDLVAHLRVLLNAVVSLQGLKLRADIVAKIDLDVILDLLVRVRVLLEDVRVQVLALLKLDLRILIKLGVNLRVILRELIPTIVKILIALVNELVVILRPVNPILADKFKYHGGLLTQLLNLVGNLLANLLRILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8P8</accession>
    <name>G0S8P8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cytoplasm protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0039900</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988042">
        <property type="protein sequence ID" value="EGS20251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694400.1">
        <property type="nucleotide sequence ID" value="XM_006694337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8P8"/>
    <dbReference type="GeneID" id="18258028"/>
    <dbReference type="KEGG" id="cthr:CTHT_0039900"/>
    <dbReference type="eggNOG" id="KOG3043">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054590_2_1_1"/>
    <dbReference type="OMA" id="GDNPHTP"/>
    <dbReference type="OrthoDB" id="17560at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="252" mass="27289" checksum="B3E4AD65D3F6FA53" modified="2011-10-19" version="1">MASNPPGRCCTLGIKHEGTPSGELIKVGAYDAYLAKPPADKAHTGAGILFLPDVIGIWQNSKLMADQFAANGYVTLIIDTFNGDPLPLGPRPAGFNIHEWIAKGSDGKNPHTTEAVDPIVVEGIKYLREVHGVTKLGAVGYCFGAKYVVRHYKSGIQVGYVAHPSFVEEDELAAITGPFAISAAETDTIFPAEKRHKSEEILKAAGVPYQINLFSGVEHGFAVRGDPNVKISRFAREQAFLQAVTWFDNWLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>G0S942</accession>
    <name>G0S942_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0044460</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694838.1">
        <property type="nucleotide sequence ID" value="XM_006694775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S942"/>
    <dbReference type="GeneID" id="18258484"/>
    <dbReference type="KEGG" id="cthr:CTHT_0044460"/>
    <dbReference type="HOGENOM" id="CLU_953169_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="292" mass="30743" checksum="1EC342475E542D09" modified="2011-10-19" version="1">MKDLTLLRRSRSAPPSGTNLSNTHLTHLGMPPGTSSVDHRTCSREPSPEPLPDRKHWGKISKDLPLALWLKTNDNVLSSRNSVAAAAAIPRSFSLPALPGPEQMDLTSDGRSTGEPQVEGEYIFTPMDVVFPVLPHAPCPPSVPTPGANSFLGSGAGTPAPVAGPSSACFGTPPSIQKRPRKNSYSAPCPAPISGLFGSVPLGFSPAPWQHKPPALQDLPIPPGGLSNRASSDSGGMMEVEMELDRQGVARVIAEVGRRLGRIQLASRGGDGEGDIEMEGMEEGEEGDLIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G0S985</accession>
    <name>G0S985_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0044920</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694881.1">
        <property type="nucleotide sequence ID" value="XM_006694818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S985"/>
    <dbReference type="GeneID" id="18258530"/>
    <dbReference type="KEGG" id="cthr:CTHT_0044920"/>
    <dbReference type="HOGENOM" id="CLU_709800_0_0_1"/>
    <dbReference type="OrthoDB" id="4590737at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408963" evidence="3">
        <location>
            <begin position="24"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS19996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="389" mass="39642" checksum="6A63ED14B992FDB9" modified="2011-10-19" version="1">MKLQKILLPLVAISAHGAGVAAAAQISLNTSTGGLSPGAAAGITAGAVAGLAAIIAVVFLLWRKKQGGLRGALVTADYPSGMNMSPMNAGPSSGPRSGGGGATAGNETVPMEMGDGGVSQAGGQEGMMMQNGTGMGMRGGGKESFYTTSTEETPIAGNGYGTSPYVMPPASMMPPEPGYTQLVPPPASQQHLAPQRWESTVSRPVSDMTTNSTTGPTLNEPSLPVSPLSPPYYANTLPAPAPAAMGGGYQSPYQPPQPQRQYSAYTPQITLTHDQEQGEQAPRTSEEFSSSQPLPKTRHPIDLGNSPTIPTFLIPGGDRARALSFASVMSAGSSGGQGYGQRSAEVIGSGPNPGRAAMVPVAEEEPKPAQKRGGGANVIPSCSEQNRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9I3</accession>
    <name>G0S9I3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5-demethoxyubiquinone hydroxylase, mitochondrial</fullName>
            <shortName evidence="8">DMQ hydroxylase</shortName>
            <ecNumber evidence="8">1.14.99.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ubiquinone biosynthesis monooxygenase COQ7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">COQ7</name>
        <name evidence="10" type="ORF">CTHT_0045990</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + AH2 + O2 = a 3-demethylubiquinol + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:50908"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="1.14.99.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="8">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the COQ7 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.60" evidence="8"/>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694979.1">
        <property type="nucleotide sequence ID" value="XM_006694916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9I3"/>
    <dbReference type="STRING" id="759272.G0S9I3"/>
    <dbReference type="GeneID" id="18258637"/>
    <dbReference type="KEGG" id="cthr:CTHT_0045990"/>
    <dbReference type="eggNOG" id="KOG4061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071892_0_1_1"/>
    <dbReference type="OMA" id="WSTAVMG"/>
    <dbReference type="OrthoDB" id="275371at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008682">
        <property type="term" value="F:3-demethoxyubiquinol 3-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01042">
        <property type="entry name" value="DMQH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01658">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011566">
        <property type="entry name" value="Ubq_synth_Coq7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237:SF4">
        <property type="entry name" value="5-DEMETHOXYUBIQUINONE HYDROXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237">
        <property type="entry name" value="COENZYME Q10 BIOSYNTHESIS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03232">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0830">Ubiquinone</keyword>
    <keyword evidence="2 8" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS20094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="260" mass="28959" checksum="A23AD3AC1680EE44" modified="2011-10-19" version="1">MASRPVLRTARVLLPATPSRLFSTTAPTTSTTTSSSSSSFSSSSSPTSPSSISQPKGDGQQPPKSTKGRKPLTPEQRTMLSRALRVNQAGELAATLIYTAQTPLVVSREPHLRPLMQHMYDQEEGHLRTFNELIHRHRVRPTALYPLWQVLATGLGWTTAMLGREAAMACTEAVETEIGGHYNGQIRDLLAMVEGWEREGYEVGEEFRSLIETLRKTRDEELEHLDHAVEHDARKAEPHWLLTGIIRLGCRGAIWVSERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9K2</accession>
    <name>G0S9K2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="11">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CTHT_0046180</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="11 14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="11 14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="11"/>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006694935.1"/>
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    <dbReference type="AlphaFoldDB" id="G0S9K2"/>
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    <dbReference type="GeneID" id="18258656"/>
    <dbReference type="KEGG" id="cthr:CTHT_0046180"/>
    <dbReference type="eggNOG" id="KOG1526">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023296_1_1_1"/>
    <dbReference type="OMA" id="HGTVQRH"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:magnesium ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
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        <property type="entry name" value="nadp_idh_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PRK08299.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="6 11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 11 14" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 11 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11 15" id="KW-0521">NADP</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="16">
        <location>
            <begin position="78"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="144"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="163"/>
            <end position="169"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="378"/>
            <end position="383"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="12">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="12">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
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            <dbReference type="ARBA" id="ARBA00023554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-2"/>
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    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-4"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGS20113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="482" mass="53676" checksum="5EBE526F5FBBDAA4" modified="2011-10-19" version="1">MSSAASSALRASLLRSSASSRSAAAAAAAARPAFSNLRASPVSVSARAAPVYVFSQHFISRRTMATDAPIKKIKVKNPIVELDGDEMTRVIWKDIKEKFIYPYLDVDLKYYDLGIEYRDQTNDQVTIDAAEAIKKYSVGVKCATITPDEARVKEFNLKQMWLSPNGTIRNILGGTVFREPIVIPRIPRLVPGWKKPIIIGRHAFGDQYRAKDTVIPGPGKLKMVYVPEGGEPQEIDVFEFKNGGGVAQTQYNTDESIRGFAHASFKLALDKGLPLYMSTKNTILKRYDGRFKDIFQELYDNEYKPLFEAKGIWYEHRLIDDMVAQMIKSSGGYVMALKNYDGDVQSDVVAQGFGSLGLMTSVLITPDGKTFESEAAHGTVTRHYREYQKGKETSTNPIASIFAWTRGLVQRGKLDGTPEVVAFAEALEQACIDTVDIDGIMTKDLALACGKTAREDYVTTREYMDAVDKRLRKSLQEKLQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9L1</accession>
    <name>G0S9L1_CHATD</name>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0046280</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="eggNOG" id="KOG1616">
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    </dbReference>
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    <dbReference type="OMA" id="NELEFQH"/>
    <dbReference type="OrthoDB" id="5873279at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-activated protein kinase glycogen-binding" evidence="2">
        <location>
            <begin position="4"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
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            <begin position="123"/>
            <end position="216"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <end position="423"/>
        </location>
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        </location>
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        </location>
    </feature>
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            <end position="936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS20122.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="972" mass="105691" checksum="C589CE4012335C4B" modified="2011-10-19" version="1">MPSFTFQWPHDAQEVYVTGTFDNWSKSERLEKVDGVWQKTVTLPERAEKFYYKFVVDGNWTTDHTAPQEKDAEGNENNVLLPEQIMDANSKPEVEEAAQLQAATISSAAPESTTTQLVAAVPVEEKKEEPQPEVKKGEKEEELKEETTPGDSKEEAPKEEAPQEETAKEETPKEEQKEEPKVEEKPEEKKDDPQEEEKKEEPKPKEDEKEEEKPESAPEVAPETVVISSVAPESTTAELAAAVPLENKEDAAPAEPAADSSEVKVDPLPAAEGALNPIKLEPGEPVPKDVSAEALTSHVTLDKESYERSDRLPGVTPVATDLSPVTANMIPESSLPIASAGSDNVFISTVTAESTTADLAAEVLVEKPSGEAAAEVPKAVKESQEKAHVDPEASAVPEEVCEKAEVEQELLSKVPEVPPAAEGVAEEKPAEQAGEEKPVEAAAPAVEEKEEKPVEKAKIEEAKAEEATEKAAEEAKPTDGVKVEEHKGEEAPPEEPKAESNAEEIKVEEPNAEETKTEQAKPEEPKTEEAAPEESKVDEAKVEEPKAEESKSAEEAKVEEPKAEEPKPAEEAKVEEPKDEEPKPTEEAKVEEPKDDATEEVRSAEEPAVPAVEELKVEEAKPVEEPKPAEEVKAEEPKVEEPQPAEEVKPAEEPKAEETQQVEEANSADEVNSADEAKPAEEAKPAEEAKPAEEVKAVEETNVEEPQPAEETKPAEEVKAVEVKAVEETNTEEPQPAEETKPAEEAKPAEEVKAVEVKAVEETNTEEPQPAEETKPAEEAKPAEEAKPAEEVKPVEEVKAVEETNVEEPQPAEETKPAEETKAVEEAPAAVEEAPKVEEPKVEEPKVTEEAAKPEESKPSEEVAQPVEETPKAEEPKAEKTQLAEEPKAAEPTEAVTEPSAGAGEETAKANEEAKPSEESKPVEEDKPAEEAKAGEEQPPANGEAAKEETPSEKKKKTRLSGFWARLRERWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9U2</accession>
    <name>G0S9U2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0047180</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695088.1">
        <property type="nucleotide sequence ID" value="XM_006695025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9U2"/>
    <dbReference type="STRING" id="759272.G0S9U2"/>
    <dbReference type="GeneID" id="18258756"/>
    <dbReference type="KEGG" id="cthr:CTHT_0047180"/>
    <dbReference type="eggNOG" id="KOG4237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035565_0_0_1"/>
    <dbReference type="OMA" id="MVGFKAN"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="158"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS20203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="460" mass="49685" checksum="948F7900212730E4" modified="2011-10-19" version="1">MATIAIHDLITLQQGGYRDANLTHLKLASPLTSFPEEILSLGLSLTTLDLSGTGLSSLPSNLGAALPNLKTILLDNCSFAIFPSEAVSSCPNLTIVSLANNQISSIPEDIPLPSALETLIVTNNRLTSLPKVPFVPCKNLSILRLSHNSLTSLPRWLFTSLPSLSQLSFAANPCCTACQVPNGVHRGCCALADIPFKELEQQSEEPVPSLGFTTATVCKGQWKQSEEYAEEVAVLTFWGKKGEQEMDVWIEAGAHESLLSVWGRVTGHPGEDTDEEEGFKGAIVAQLVPEGYYPLAKPPSALDLGISSTTEEDSQPLELSHSSALAMLASIAGALSHLHEQGIAHGNLHPSNILASTELEHALLVGFGEATIYRHGNLSERSGVEKIEVLAFAKVLEHVLGLVKPGSEGDEERERLVRRGLEELRARCSAPGVEERPAFEEIREALEEMVGWRRMMRIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAA5</accession>
    <name>G0SAA5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0041560</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694562.1">
        <property type="nucleotide sequence ID" value="XM_006694499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAA5"/>
    <dbReference type="STRING" id="759272.G0SAA5"/>
    <dbReference type="GeneID" id="18258194"/>
    <dbReference type="KEGG" id="cthr:CTHT_0041560"/>
    <dbReference type="eggNOG" id="ENOG502RYBR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020985_1_1_1"/>
    <dbReference type="OMA" id="CANTHTS"/>
    <dbReference type="OrthoDB" id="3021074at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="545"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="582"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS19677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="647" mass="69256" checksum="2145C0D9C1249805" modified="2011-10-19" version="1">MPALPEIDFLTLLSDTSNKSFSNSSTQDDNNSLSPLKVICAWPVSGQYGAGSRFLYYVLVATCVLARKTEWLRNAALAAALVFPAVSGIHGIVLAAMDRKGGVDLDVYGALQFCAVGALTAPVTVRFSKTYFNTPGRNVIFLWTLIVLAGLMALTVEFFRLGPLPCADGGDGLPLYRLQDFEYGTTMCGLICSAEDGPHSPMRAGSANDIYVVPAPYVLTFGAATLIAAGSCIPPILSLISTWEKINFLNWQARWGRQRDVDSEPATSTNASEIHADCAGSPAEALGNTAQLNGVDNNLARGEVALPEPPPESTEQMMKINATIRELLNVIEFIVFSGAVVALIIVGEMNFWSQWAPIVASLLAACGSLYMLLAEEATDLECEHGPCQRCANTHTSICLHQHTAMSTAALIQSDNSEMAETCRPQIASTEPTLSGANPEWENENHGLANSVPPTGAESSSGWSRMRVERFLRRVAESLQTPSRDRYDDTQVRRNALSYPLVPGEDLRVPRFNEIIAAWDVVTTFAGRSRSSSLQNGAPGSGKIVTSSRSNSTSPTNRVPQTPTTSVLSSTGKLLDVPQFGQSPLSTASSGAGLSISSKSESEAPRQQPPAVPPIIITDSEQASEKMEGRHRSIPASTMMSPTTSEPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAB2</accession>
    <name>G0SAB2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0041650</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694569.1">
        <property type="nucleotide sequence ID" value="XM_006694506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAB2"/>
    <dbReference type="STRING" id="759272.G0SAB2"/>
    <dbReference type="GeneID" id="18258203"/>
    <dbReference type="KEGG" id="cthr:CTHT_0041650"/>
    <dbReference type="eggNOG" id="KOG1652">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087811_3_0_1"/>
    <dbReference type="OMA" id="FDCTFQY"/>
    <dbReference type="OrthoDB" id="2261329at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485:SF0">
        <property type="entry name" value="AT05822P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS19684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="154" mass="16205" checksum="DF352E7B037512F3" modified="2011-10-19" version="1">MDHTRDPCPWVILNDFGGAFCMGAVGGTIWHGVKGFRNSPYGERRLGAITAIKMRAPVLGGNFGVWGGLFSTYDCAVKGIRKKEDPWNAIIAGFFTGGSLAIRGGYKAARNGAISCAILLAVIEGVGIGFQKMFAGATKLEAPQPPPSGDKMLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAD7</accession>
    <name>G0SAD7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0041910</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPA43 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694594.1">
        <property type="nucleotide sequence ID" value="XM_006694531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAD7"/>
    <dbReference type="SMR" id="G0SAD7"/>
    <dbReference type="STRING" id="759272.G0SAD7"/>
    <dbReference type="GeneID" id="18258229"/>
    <dbReference type="KEGG" id="cthr:CTHT_0041910"/>
    <dbReference type="eggNOG" id="KOG4134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036411_2_1_1"/>
    <dbReference type="OMA" id="DEYGVLY"/>
    <dbReference type="OrthoDB" id="10250504at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055029">
        <property type="term" value="C:nuclear DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04328">
        <property type="entry name" value="RNAP_I_Rpa43_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041901">
        <property type="entry name" value="RNAP_I_Rpa43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041178">
        <property type="entry name" value="RPA43_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17875">
        <property type="entry name" value="RPA43_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="9">
        <location>
            <begin position="186"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="RPA43 OB" evidence="10">
        <location>
            <begin position="274"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="319"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="418"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS19709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="472" mass="53225" checksum="4CCEC033C362A9A4" modified="2011-10-19" version="1">MSAATAGDPHAAEVPSSQPTEKKHKRSKSDHKKKRLREDDDGAVVAETPRKQKKTKSESADEAEVEKSHEVVDEKVEKKKKKKSKEEGEDGTNKKEKKSKRRESAVMDAMDVDGTEEKTEKKKKKDKKRIDDTQEAEPSDEEKKDKKKKKHKPKEPVTMDIPIREAQPSTDIPSDSDFPFYTQTISLYVPFFPAGFDKPLTNIAAQHLDPLLNHYSPILRGVLLSYSNLNLSDRPVRASTIHPPTDQTPALLHSINEYAVGFGWLTFDAHLFVPARGKWMEGVVQLQNEGHIGVVCWNKFNASIEAKRLPKGWRWVDLAKGNANPKPEPPAEEQPQDSSKSDSSDALDGEELQVIEQMHTTGYWVTAQGKRVSGKLRFRIKNFDVGLAGDYGYLSIEGTCLDDAEEQALAAQEREMERQRRAKQQARGGLLRPMSRRVPEFSMTRFGREEQEEDGQGRAVLYRGSRPGTPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAE8</accession>
    <name>G0SAE8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0042020</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694605.1">
        <property type="nucleotide sequence ID" value="XM_006694542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAE8"/>
    <dbReference type="GeneID" id="18258240"/>
    <dbReference type="KEGG" id="cthr:CTHT_0042020"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005562_0_1_1"/>
    <dbReference type="OMA" id="PLREWHP"/>
    <dbReference type="OrthoDB" id="3142841at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052979">
        <property type="entry name" value="Adenylate-forming_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927:SF5">
        <property type="entry name" value="ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01222)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="446"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS19720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="721" mass="79941" checksum="E957A0748F5D7D36" modified="2011-10-19" version="1">MSPQQPSPSDNAQPSNPFSPATMASPETPLAHFPNPAQARLPPNARVRTVRSHSLPWSPNIAQRLPTYFMMPALPFRSQPLPTPADTNTRKTVMTYEESDCESDPSGDESPEEPKSPFSSSRSRQSRVSFLRRPSTTSNPTPTPILSPPSPPRDIEEAAADNARTPTHASNAPVNNNNNNNNNNNNNNTRSLSSPSPQQVPNLNEEKPPANPTDVFLAHNLSPLPLPPKKGTRFYRHLRHTFLSIYCRLFCLVFLANTIALITLLERHTSGSRTEKSQGLTYHGAITATTSNLLAAVLIRNEHVVNTLFWTLGTATKYAPLRVRSLAARVYTYGGVHSGGAVAAVGWYVSFLVLLTRELTSRQEVTVVRSWVYFVAYAILAVLVSILCTAHPKFRRVMHDWFEVIHRFGGWLCIILFWVLLVLLAAENRSPDGATIGKTLVREPNLWMLVTITGLVVYPWTRLRKREVQAEVLSPHCVKLTFRYRNVQFGQAVKLTDRPFKETHAFGVIPLPTASNVPQVRTEMMMMMMKGRCSGCCSSPSPSSPSPSPSPPSQDKPQTRGKAEEKGFSVIVSKAGDWTSSLIAHPPSKIYTRGVPQFGVLRIAALFRPVLLVATGSGIAPILSLLIQVPHHPVRIVWSTHDPEATYGRDICDVVYRSDLHAVVVDTSRVKRPDLVKLCYRVWEQEGCEAVVVISNQRVTRKVVYGLESRGVRAFGPIFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAF0</accession>
    <name>G0SAF0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nitrate/nitrite transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0042040</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694607.1">
        <property type="nucleotide sequence ID" value="XM_006694544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAF0"/>
    <dbReference type="STRING" id="759272.G0SAF0"/>
    <dbReference type="GeneID" id="18258242"/>
    <dbReference type="KEGG" id="cthr:CTHT_0042040"/>
    <dbReference type="eggNOG" id="ENOG502QPIC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024204_1_1_1"/>
    <dbReference type="OMA" id="IPCFMFA"/>
    <dbReference type="OrthoDB" id="434240at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015113">
        <property type="term" value="F:nitrite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004737">
        <property type="entry name" value="NO3_transporter_NarK/NarU-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00886">
        <property type="entry name" value="2A0108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="HIGH-AFFINITY NITRATE TRANSPORTER 2.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="474"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="210"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="221"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="269"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS19722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="498" mass="53248" checksum="A429FCFD651DB10D" modified="2011-10-19" version="1">MGFKSRLSTLWAPPQLNPVTKKARSIPLLNPLDRHGRVFFFSWMGFMIAFWAWYTFPPLLTVTIREDLHLTKTQVANSNIVSLSATLLIRLISGPLCDAIGPRKVFALVLLLGSIPVGLAPLIHNAAGLYTIRFFIGILGASFVPCQVWCTLWFDRNVVGTANGLAGGWGNAGGGVTYFIMPAVFDSLVGKGLTPGKAWRVTFVVPLGGGPTATKQSKPTSPSPPLTQPTRPPTPIRSSLSQAPLPPALHPPPAHPTPTLAPRKSKAPLPLPPSPRPKPCHPLPPEIPLPPSLHTAIPILLSPQCLFHVLTYACSFGGELAINAVLSSYYLSLFPTKLTQTTASNYAAIFGFLNFLTRPLGGVIADLLYNLAPARYKLWSKKLWITTCGVLTGSLLILIGLYKSPSLAVTIALVCVMAFFHEAGNGANFALLPHVFPQANGLLSGVTGAGGNLGGVVFAIVLRFMDGGTNYSKGFWVIGIVHVVVNLAVCWVRPVAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAI3</accession>
    <name>G0SAI3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS7m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0042390</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694640.1">
        <property type="nucleotide sequence ID" value="XM_006694577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAI3"/>
    <dbReference type="STRING" id="759272.G0SAI3"/>
    <dbReference type="GeneID" id="18258277"/>
    <dbReference type="KEGG" id="cthr:CTHT_0042390"/>
    <dbReference type="eggNOG" id="KOG3291">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049057_1_0_1"/>
    <dbReference type="OMA" id="TAFKWIL"/>
    <dbReference type="OrthoDB" id="9972728at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14868">
        <property type="entry name" value="uS7_Mitochondria_Fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.455.10:FF:000006">
        <property type="entry name" value="37S ribosomal protein S7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047988">
        <property type="entry name" value="Ribosomal_uS7m_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 10" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="9">
        <location>
            <begin position="136"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="44"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS19755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="308" mass="34082" checksum="CBE4C08A22A926D8" modified="2011-10-19" version="1">MPPRLNIWSACRSLSLAVRTRAAVKAPQMSGPVALLSRGLADNISSRQPPFFPQNKSPQGIPPYSPSQGQPQPQPQPAIQAQTEPETETYTSPENERAINQLRMIEYGLDPLDPAVEGHKFGLPDLPLPPEKTQKHRYDDVLQLVTRLMMKDGKLAKAQRDVAMVLNYLRTSPPPKIDPSKPLIPGHPPAQHLPLDPITYMTVAIDSVAPLIRMRGFKGLAGGGRSLEVPVPLKARQRRRTAINWILEVARKKPNRGSGRGTWPHRVAEEIIAVVEGRSPVWDKRTAIHKVGTANRSNLNHAQVKGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAK7</accession>
    <name>G0SAK7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial 2-oxoglutarate/malate carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0042630</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694664.1">
        <property type="nucleotide sequence ID" value="XM_006694601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAK7"/>
    <dbReference type="STRING" id="759272.G0SAK7"/>
    <dbReference type="GeneID" id="18258301"/>
    <dbReference type="KEGG" id="cthr:CTHT_0042630"/>
    <dbReference type="eggNOG" id="KOG0759">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_14_1_1"/>
    <dbReference type="OMA" id="TLWRGAI"/>
    <dbReference type="OrthoDB" id="756301at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000009">
        <property type="entry name" value="Mitochondrial 2-oxoglutarate/malate carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
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        <property type="entry name" value="Mito_Metabolite_Transporter"/>
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    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
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    </dbReference>
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        <property type="entry name" value="MITOCARRIER"/>
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        <property type="entry name" value="SOLCAR"/>
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    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
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    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
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            <begin position="228"/>
            <end position="248"/>
        </location>
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            <begin position="291"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
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            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
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    </evidence>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGS19779.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
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    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="33481" checksum="0093DBC66F68C1A0" modified="2011-10-19" version="1">MMGTAKSDSAVVANDFLHTPFMRAALPFINGGISGMVATTVVQPVDMIKVRIQLAGEGKAGGPKPTPLSVTREILASGKALDLYTGLSAGLLRQAVYTTARLGFFDTFMSALSSRAKANGNQVGFTERATAGLAAGGLAAMIGNPADLALIRMQSDGLKPVAERKNYKSVIDALTSIARSEGVGALWAGAAPTVVRAMALNFGQLAFFSEAKAQLKKHTDWSANTQTLSASAIAGFFASFFSLPFDFVKTRLQKQQRGPDGKLPYNGMADCFAKVARQEGLFRFYRGFGTYYVRIAPHAMVTLIVADYLAWLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAM1</accession>
    <name>G0SAM1_CHATD</name>
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        <recommendedName>
            <fullName evidence="4">Altered inheritance of mitochondria protein 21</fullName>
        </recommendedName>
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        <name evidence="2" type="ORF">CTHT_0042770</name>
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        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
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        </lineage>
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        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
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                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Aim21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11489">
        <property type="entry name" value="Aim21"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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        </location>
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        </source>
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        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="936" mass="100986" checksum="E9213504642CCAE1" modified="2011-10-19" version="1">MSATAAAQPPAIPPRPSRSPEKTPPMIPPRPAKRLQRSISPNPDRFAPSPLNEVPFNKAKELLQAQHAESAPKRHSVELPSLGEEGMEYARLTEELALANEEEPKPEQTRTIASDLQLHAPKPSLPAASAKQRVQTVTRTDSERAAAFGIGKPSSVEGSSPAPGVPTRPSLKKKASSASQLSATSLPEDEQGIPEIGQQVPMYPNAGDVQAPSPALSNKNHHRKGSALGHLPLDTYGLHGHGIIPQNKLEKAYYEKHPELLKKERVPHHYDRPNDFSMSQEDLNKIVRETAVRGTGVGATDYSGTPSEQVAWQALEESVSRSASPRPASPDKQAASLAEVIHVDEPNRRKSVMFSDSESANEEIEHPYTAPILAEDEVAKDPTAVLTKEPAVEPPTIEEPVSRSSSRAPSIRRVTLEPKPEPQEETEEYEPLFKDDDKAKERRPSIQEALKNNHKKQRFPSADIWEDAPSSVFYTAEVSAPELFEGGDDEEKPEPVVKVSPPPEIETPAIVFARQQEELVEKEYQQYGPEGFPAARGSKPPVKEEEKPSGPAVVPARPASRFPSRDVWEDAPESAQLETEVSAPQKEEDEEAEASPVEEAKPELPERPQQPPKPASEKPATPERRPIKPRQVSVNGEDHTKPAIPDKPKPQIPPRPAARPAPAAVPTSGASSEPSAETAAPAPRPKPAVPARPIGSKIAALQAGFMNDLNRRLQLGPQGVLAAKLKEKEKEEQSSGSGSTEEGGEEKVEAKEKAPLSDARKGRARGPQRRAPTSVAAAAAAAAAAAPPPVKEEPEVSFAFSVAKTVFEIDPEDGTLSTADEAVQEEKSAPVEKVEPKPAAESEAKVEETPVPSAEGKSEEKVTEAEPEKKGPEPEPEPESEAKVQTAEEVKDEKKVTESTPGPETKSLATNMAGEPLIEEEIKKGGEEETVKATQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAR2</accession>
    <name>G0SAR2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0043190</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006694656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAR2"/>
    <dbReference type="STRING" id="759272.G0SAR2"/>
    <dbReference type="GeneID" id="18258357"/>
    <dbReference type="KEGG" id="cthr:CTHT_0043190"/>
    <dbReference type="eggNOG" id="KOG2118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011310_3_0_1"/>
    <dbReference type="OrthoDB" id="5353557at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF21 and CBS domain protein"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACDP"/>
    </dbReference>
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        <property type="entry name" value="CBS_dom"/>
    </dbReference>
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        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF97">
        <property type="entry name" value="METAL TRANSPORTER CNNM-5"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01595">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5 7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="11">
        <location>
            <begin position="58"/>
            <end position="243"/>
        </location>
    </feature>
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        <location>
            <begin position="324"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="407"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="494"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="572"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="675"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="533"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="591"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="629"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="708"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="729"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="755"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="784"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="799"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS19834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="816" mass="88194" checksum="7AC464CA7300D0A7" modified="2011-10-19" version="1">MQSITPLPSRSVSLRSHGSGLLALRSTAVGLARLLSMTMSVAYAAPLHHLGEKKPETKGASLWVLYLISVVLVLAGGAFAGLTIALMGQDGIYLQVMARDPNEPQQKNAKRVYDLLQNGKHWVLVTLLLANVIVNETLPVVLDRCLGGGVAAVVGSTFLIVIFGEVLPQSICVRYGLPIGGAMAKPVLGLMYLLAPVAYPTAKLLDWLLGEDHGTVYKKSGLKTLVTLHKSLGDVSERLNQDEVTIISAVLDLKEKPVSSVMTPMEDVFTMSEDTVLDEQTMDMILSAGYSRIPIYEAGHPTNFVGMLLVKILITYDPEDCKRVRDFPLATLPETRPETSCLDIMNFFQEGKSHMVLVSEYPGEDHGCLGVVTLEDVIEELIGEEIIDESDVYIDVHKAIRRLAPAPKARLPRRPSVDQQPRRPRSGTMPCECSTDGPSICAPPRRSLDSPALSGSPKTTIMMRRSSAGLDGQWVQTTVPVRAKFEDIREHLKHLGPSNPASHPKDTRSTTVKVKPGIGGPPPSTRAGSTIDRAIEESPHLEDASETTSLLRPKSTPAKFDEAIRQRYGPSLAVPLSASPEQIDKSTQTTGNGSENANGNNNVNSNLDKLSASVPIKSPPPPPLRRITSASSVGSASVGSSSKTEHIPVPRKPYVRSGSITENVIESRGVRKVVLETMDTHHDEDHEEAVASTPSSFDGSRLFGLFMGRDKDKDKDKDKDKDKDKKSAGSRGSSRVGSPSGSTKGKNGKEKEKEDSEPEASADEDDEEDDPLLEGSRGLAAEASGRESRPGSRGGMEKKKTRRRKRKGGGWSSTVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAZ8</accession>
    <name>G0SAZ8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipid:diacylglycerol acyltransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0048370</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695200.1">
        <property type="nucleotide sequence ID" value="XM_006695137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAZ8"/>
    <dbReference type="STRING" id="759272.G0SAZ8"/>
    <dbReference type="GeneID" id="18258875"/>
    <dbReference type="KEGG" id="cthr:CTHT_0048370"/>
    <dbReference type="eggNOG" id="KOG2369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016065_1_0_1"/>
    <dbReference type="OMA" id="FYFLKWV"/>
    <dbReference type="OrthoDB" id="190846at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS19378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="637" mass="71347" checksum="B6B158A9420CF0D0" modified="2011-10-19" version="1">MANSLRRRGPTGNDTPSETTPAPTPTPRGGSSSREANDPTFKPNSSSHGHHRPKARKRKFTGIFLLGSLFGIIAAGFFAKSNDLIDFPEFGELSMDNLLDVLPAGLVKDMRDLIVGERAFLESYDSFAVGLKVRSEGLSAYHPMVMVPGVISTGLESWGITNASLPYFRKRLWGSWSMMRALVMDKEGWKRHIMLDKKTGLDPPGIKLRAAQGFDATDFFITGYWIWNKIVENLASLGYDPINSYTAAYDWRLAYRDLETRDHYFSRLKAHIEMAVRLQNRKVVLTSHSMGSQVVFYFFHWVASDQGGKGGDDWVENHIESWINVSGCMLGAAKDISAVLSGEMRDTAQLNAFAVYGLEKFLSKAERAEIFRAMPGISSMLPIGGNAIWGDLDWAPDDRPGQEHSFGSFLNFRTDQNFTVPRRNFTVEDAMNYLFETAEPWWVDQVKRSYSWGIARTEAEVAANEHDPRKWINPLETRLPLAPSLKIYCFYGVGKPTERGYFYRSPEPGSGTTLNMTIDTAVTTASGMVDHGVVMGEGDGTVNLMSTGFMCNRGWKIKRYNPAGVKITVVEMPHEPERFNPRGGPNTADHVDILGRQNLNEFILRIAAGQGHTIRDHVVSNIKDYAARAKVYEEDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0SB16</accession>
    <name>G0SB16_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0048550</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695218.1">
        <property type="nucleotide sequence ID" value="XM_006695155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SB16"/>
    <dbReference type="STRING" id="759272.G0SB16"/>
    <dbReference type="GeneID" id="18258893"/>
    <dbReference type="KEGG" id="cthr:CTHT_0048550"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026447_0_0_1"/>
    <dbReference type="OMA" id="ERITIWL"/>
    <dbReference type="OrthoDB" id="1049195at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000145">
        <property type="entry name" value="Putative RNP domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000232">
        <property type="entry name" value="RNA-binding domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000280">
        <property type="entry name" value="RNA-binding domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF3">
        <property type="entry name" value="FI21236P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="245"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="360"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="513"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="116"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="140"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS19396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="614" mass="67059" checksum="69EB2D5D1F231CE0" modified="2011-10-19" version="1">MADSDTYRPQLTPILSDVGRARWSSAGVRLNRAFARSFAGAAGRSPQFALQIGRVLGPYLAATAGARGPFPDHYGAWSLALAQPRRLKRSLAQPHPVALHPHRLVWRGCQPASLKAYSSTSSTTPPPHLPACATPIPPESATTTADNVDQPSTDMSQRERSRSPRRGRSRSPNGRRSYSPRDESRNNNHQKRRSRSPMTGQPQQTGQSSNTGYNAPPPHHGSYEDRAARREQVMNNIRETSQQDRRVYVGNLSYDVKWHHLKDFMRQAGEVLYADVLLLPNGMSKVGAYNIVEYATREQAQHAIATLSNQNLMGRLIYVREDRESEPRFGPPGGIPRGGYSGGMGGGAYGGFNPMGTAGRQLYVSNLPFNIGWQDLKDLFRQAARQGAIIRADVHMGPDGRPKGSGIVVFESPDDARNAIQQFNGYEWNGRIIEVREDRFANPGMGGPGFGRGGYGAPRGGFGYGGRGGFAGRGGYGYGGRGGFGGHGGYDNNVSMPPNPFTDNVVPGTEKCDTIFVRNLPWSTSNEDLVELFQTIGKVEQAEIQYEPSGRSRGTGVVRFDNADTAETAIAKFQGYQYGGRPLNIAYAKYLNPQQNDNAMDTDPHAGLTQDQIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0SB27</accession>
    <name>G0SB27_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase C14 caspase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0048660</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695229.1">
        <property type="nucleotide sequence ID" value="XM_006695166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SB27"/>
    <dbReference type="GeneID" id="18258904"/>
    <dbReference type="KEGG" id="cthr:CTHT_0048660"/>
    <dbReference type="eggNOG" id="KOG1546">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029389_0_2_1"/>
    <dbReference type="OMA" id="YLCRMER"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="6">
        <location>
            <begin position="196"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="81"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS19407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="492" mass="54762" checksum="668FB18E770E59EA" modified="2011-10-19" version="1">MSGYPGAGYGGGYMPPPQQQQPPYGYYPPQQPYGYQAPPPQPGYGYQPPIQQPPYGYYQQPPPQGPPQGYQYHHPAPPPQQQQQQQQQQPQQLQPQPQQFQSPANNNNNNNNNNNNNNNNNNNNNNPRPQSMSGPLYSAISLQKQPLMQRADIPTVNQNAYVQGNHNAPRPPPPTPQSFGPGAHGASFQYSQCTGKKKALLIGINYFNQRGQLRGCINDVRNMSAYLVENCGYKREDMVILTDDQQNPMSQPTKQNILRAMHWLVKDAQPNDSLFFHYSGHGGQTKDLDGDEEDGYDEVIYPVDFRQNGHITDDEMHRIMVRPLKAGVRLTAIFDSCHSGTALDLPYVYSTQGILKEPNMAKEAGQGLLNVVSAYSRGDLSGVASNIIGFFKKASNQEQAYARSMAIKTSPADVIMFSGSKDDQTSADATIQSQATGAMSWAFITALKKNPQQSYVQLLNSIRDELQTRYTQKPQLSCSHPLGKFPYNVYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G0SB59</accession>
    <name>G0SB59_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0049000</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695261.1">
        <property type="nucleotide sequence ID" value="XM_006695198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SB59"/>
    <dbReference type="STRING" id="759272.G0SB59"/>
    <dbReference type="GeneID" id="18258938"/>
    <dbReference type="KEGG" id="cthr:CTHT_0049000"/>
    <dbReference type="eggNOG" id="KOG0292">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007565_1_0_1"/>
    <dbReference type="OMA" id="EMTYQKQ"/>
    <dbReference type="OrthoDB" id="10261470at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22948">
        <property type="entry name" value="Coatomer_WDAD_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000002">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000022">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047312">
        <property type="entry name" value="Coatomer_alpha_WD-assoc_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016391">
        <property type="entry name" value="Coatomer_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010714">
        <property type="entry name" value="Coatomer_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF1">
        <property type="entry name" value="COATOMER SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06957">
        <property type="entry name" value="COPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003354">
        <property type="entry name" value="Coatomer_alpha_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="53"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="95"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="132"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="206"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="250"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="12">
        <location>
            <begin position="345"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="14">
        <location>
            <begin position="617"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer alpha subunit C-terminal" evidence="13">
        <location>
            <begin position="830"/>
            <end position="1210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR003354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS19439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1212" mass="135981" checksum="657C7669069F706F" modified="2011-10-19" version="1">MQSSTGMLTKFESKSSRAKGIAFHPKRPWILVSLHSSTIQLWDYRMGTLIDRFEEHDGPVRGVDFHKTQPLFVSGGDDYKIKVWSLQTRRCLFTLNGHLDYVRTVFFHHELPWIVSASDDQTIRIWNWQNRSLRHNHYVMCAQFHPKEDLVVSASLDQTVRVWDISGLRKKHSAPTSMSFEDQMARANANQTDMFGNTDAVVKFVLEGHDRGVNWVSFHPTMPLIVSAGDDRLIKLWRMSETKAWEVDTCRGHFQNVSGCLFHPHQDLILSVGEDKTIRVWDLNKRTAVNTFKRESDRFWVIAAHPEINLFAAGHDNGVMVFKLERERPASAVYQNTLFYITKDKCVKSYDFQKNIESPTLLSLKKLGSPWVPPRTLSYNPAERSVLVTSSADGGVYELINLPRDGSGAIEPTESKRGQGNSAVFVARNRFAVLNTSTQTIDIKDLSNNTTRSFKPPIGTTDIYFGGTGNLLILTPTVVYLYDIQQKKTTAELAVNGVKYVVWSNDGLYAALLSKHNVTIVTKNLEQVSSLHETIRIKSATWDDAGVLLYSTLNHVKYTLLNGDTGIVRTLDQTVYLVRVKGRNVYCLDRAAKPRILQIDPTEYRFKLALVKRNYEEMLHIIQNSSLVGQSIIAYLQKKGYPEIALQFVQDPATRFELAIECGNLEVALEVAKELDRPKLWTRLSTEALAHGNHSIVEMCYQKLKHFDKLSFLYLTTGDNSKLARMARIAEHRGDVTSRFQNSIYLGDVQDRIQMFKEIDLYPLAYMTAKSNGLEEECQAILEATGLTEEQLNLPTFGEPLTPPKPVVPTYKANWPTKATSQSVFEQALLGQVEALTLEDERAAANVEEGEEEAVGKRDLIANVDEDGDTAGWDIGDDIVAEVEEAIVTVDGAETGGAASSEADLWARNSPLAVDHVAAGSFETAMQLLNRQVGAVNFAPLKPRFLEVYQASKTYLPASAGLPPLINYVRRTVEETDPRNVFPIIPRDLEYLAANDLQRGYEAMKANKLEDGLKIFKGILHAVLINAVGSENEVAEARKLITSAREYVVAMSIELGRRALGPQDVVSKDPQLLKRSLELSAYFTIPKIEVLHRQLTLLSAMNWAMRNKNYNSALSFANRILANGVVAKFLESARKTKAQCERNPHDAVEIEFDQFAEFEICAASHTPIYSGTAYEECAFDGAKYHTKYKGTVCVVCEVCEVGKHGSGLKLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0SC22</accession>
    <name>G0SC22_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Allergen Asp f 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0055620</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695893.1">
        <property type="nucleotide sequence ID" value="XM_006695830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SC22"/>
    <dbReference type="GeneID" id="18259600"/>
    <dbReference type="KEGG" id="cthr:CTHT_0055620"/>
    <dbReference type="eggNOG" id="ENOG502SN6Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043430_0_0_1"/>
    <dbReference type="OMA" id="HFHERRT"/>
    <dbReference type="OrthoDB" id="118256at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019863">
        <property type="term" value="F:IgE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038903">
        <property type="entry name" value="Allergen_Asp_f_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42039">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42039:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25312">
        <property type="entry name" value="Allergen_Asp_f_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409041" description="Allergen Asp f 4" evidence="2">
        <location>
            <begin position="19"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS18948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="31508" checksum="9E813E4A0621A7D1" modified="2011-10-19" version="1">MQLTPLVLLTGLLGSVAAHPSGHAHMHRMVHVSERGLPFVKNVHNRPTAEPKTTAEPAPASTQAPEPKATIQSTKQTESEVKGFCGSSTGLLDSKAKRVTIAQVMYTGNLGTDNGCEWGSNLMVVSNDVAHKYKYVQKYTNVDDKPYQVVCGNKMGADRQLTGMFKVKGQNNLIFTLAPGETKAVVADENTQGVCAFAPYEVPLTSHGQYAGVWAEFDFGNTSNNGWSGADCSSLVAQAYNMDVPGCRMSHGGVNSDILPGGIGNNAYTKGMEELDGIGLNIVPGPCTIEVKVGFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0SC36</accession>
    <name>G0SC36_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative endoplasmic reticulum protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0055780</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SVP26 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695907.1">
        <property type="nucleotide sequence ID" value="XM_006695844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SC36"/>
    <dbReference type="STRING" id="759272.G0SC36"/>
    <dbReference type="GeneID" id="18259616"/>
    <dbReference type="KEGG" id="cthr:CTHT_0055780"/>
    <dbReference type="eggNOG" id="KOG4136">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058268_0_0_1"/>
    <dbReference type="OMA" id="TMGTEPV"/>
    <dbReference type="OrthoDB" id="28257at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097020">
        <property type="term" value="F:COPII receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007277">
        <property type="entry name" value="Svp26/Tex261"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13144:SF0">
        <property type="entry name" value="PROTEIN TEX261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13144">
        <property type="entry name" value="TEX261 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04148">
        <property type="entry name" value="Erv26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS18962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="218" mass="24743" checksum="4DF61B2BD41C6EFC" modified="2011-10-19" version="1">MWLLPLVGYFGTILGFCFMTLAIASGLYYLSEIVEEHTVIAKRFLTKMIYSVMALQLLLCLVDRFPFWPTALGVFSHFIYLGNMRRFPFVKLTDPLFIASCALVLINHYVWFRHFSHRQERAYQRMSSYYDHPHDLPTFSEIASYFGLCVWLVPFSLFVSLSASDNVLPTMGSEPPVSTSSISAGGAITVNSHKRRGQGMAKALVDSVRNGIREVDLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCL1</accession>
    <name>G0SCL1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-dependent helicase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0057620</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696082.1">
        <property type="nucleotide sequence ID" value="XM_006696019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCL1"/>
    <dbReference type="STRING" id="759272.G0SCL1"/>
    <dbReference type="GeneID" id="18259800"/>
    <dbReference type="KEGG" id="cthr:CTHT_0057620"/>
    <dbReference type="eggNOG" id="KOG0389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_16_2_1"/>
    <dbReference type="OMA" id="IQDKWAA"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17919">
        <property type="entry name" value="DEXHc_Snf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="440"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="798"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="27"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="115"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="197"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="163"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="247"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS19137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="978" mass="110248" checksum="3B900D3DF0B0D9DC" modified="2011-10-19" version="1">MEFSSPATGRRFLDDDDDHQSVIMESPYFTQPTQIIEKPTAKPQPSVTISSPSSVVEVPASSPFRPSTTPQHRNRSANLMASNPTSQLHAQKPFTISKTSHKREFVMISDGELDAPIYAGDDSSDDDERLATRADIRPSSFERKQPATTNITAYRAQAEDKQSPAQGKPGTSASNGTSKQYVLQNDWVSVSSDSSDELEHLCPAKPPQQTIRRRLVRGCRPRVSSPDGPQVNPGKLSAARVKVIDLVSDDDHDNDDEEDNYQPGKDSHHHSGFEENEEQELNDRVLAYLNSCDAIGLMAIANIKEASAKAMVSRQPFHDLSEAQAVAMAQKKRGKKSAKVVIGEDIVYAVKSYARALDSIDRVIAVCEDNAKKIKSVTSKWNIDQTGQCREEFKNADDKILTPHSAEGSTRLMDVPLRQPKLMTGCVMKPFQIYGLNWLYLLYKNQHGAILADDMGLGKTCQVISLMCSIVEQWERTGGESGPRPWPNLIIVPPSTLENWENEFKKFAPKLRVTKYQGSQAARDDILDEILDDPSNHHVILTSYSQLTREKELKDLAKCHPKVAVFDEGHKMKNPNSQFYKRLLKFKNSWRLVLSGTPVQNNLMEMIALLRFVSPNLFTAHFETLEELFSQKFSLADVSKGALLRSERVDRARTILEPFILQRRKEQVLKDLPPKLTRIIKCQMDPVQAALYKEYERRFKKSGVQNSLPSDNNIWMQLRKAAIHPQLFRRFYKDKDIEKMASILFKKVPQRDLKQPKLEHLVNELKALSDFELHLWCRDYSCIKNFDLPKGSWLDCAKVRELLKLIRGYMANGDRALVFTRFAKVLEILSECLADENIPYLALQGNTSVDERQDMINEFNSNENIPVFLLTTGSGGTGVNLASANKVILFDLSDNPQDDIQAENRAHRLGQTRPVEVIRLISEGTIEELVHKACEKKLELANKVTGWTDVSMTSEEMEKIVKQSLLSGEGVATPLSND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCV6</accession>
    <name>G0SCV6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Cyclin-dependent kinases regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0058520</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the CKS family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696172.1">
        <property type="nucleotide sequence ID" value="XM_006696109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCV6"/>
    <dbReference type="STRING" id="759272.G0SCV6"/>
    <dbReference type="GeneID" id="18259890"/>
    <dbReference type="KEGG" id="cthr:CTHT_0058520"/>
    <dbReference type="eggNOG" id="KOG3484">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140546_0_0_1"/>
    <dbReference type="OMA" id="RPINYGQ"/>
    <dbReference type="OrthoDB" id="440676at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.170.10:FF:000002">
        <property type="entry name" value="Cyclin-dependent kinases regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.170.10">
        <property type="entry name" value="Cyclin-dependent kinase, regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000789">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036858">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01111">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00296">
        <property type="entry name" value="CYCLINKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01084">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55637">
        <property type="entry name" value="Cell cycle regulatory proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00945">
        <property type="entry name" value="CKS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00068939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU311113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS19227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="123" mass="14613" checksum="25AB14B20EB8388E" modified="2011-10-19" version="1">MPAGQSLAEQMGIDISRRNPQPRPLTEEERARLDEFIDSIHYSTRYSDSEYEYRHVQLPKAMLKAIPPEYHDKSKGTLKLLWEEEWRGMGITQSLGWEHYEVHEPEPHILLFKRPLNYQPPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0SD01</accession>
    <name>G0SD01_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF155 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0058980</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696217.1">
        <property type="nucleotide sequence ID" value="XM_006696154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SD01"/>
    <dbReference type="GeneID" id="18259936"/>
    <dbReference type="KEGG" id="cthr:CTHT_0058980"/>
    <dbReference type="eggNOG" id="KOG2861">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011220_3_0_1"/>
    <dbReference type="OMA" id="NERCQVF"/>
    <dbReference type="OrthoDB" id="18302at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF4">
        <property type="entry name" value="SPORULATION PROTEIN RMD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="545"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="4">
        <location>
            <begin position="338"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS19272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="637" mass="70927" checksum="AB2CF5306475E557" modified="2011-10-19" version="1">MSIQPPKKSPAVLLTDARSRPQDRSSNPPSRSPSAVQRTAPGAAPRNTRISVDNVLQYASDIPSGQPRGPPPSHLLTQQRQTTRMGALIRRPSQPSVGMGMGMGMGESRGLPTLASARTGQQNVPSRTTKVSEKLVLLPETDGGKGLDEDEEGTGLEQRSEEEEEEFARPLTDEELDVLRKRGGIRGKSYAERLPKVERSQKVARVTAYCTAQAYKLEQTAEFLKKRHEAKTKRYDDCLYVAYHLPLLPGHKGYRLRSRPVLRTPGTGKTLLDIEIERSENRDEHMGVGEDGAPLGSSPGKVTILEEIPHRRGKGEEGEEPQRPLKRIIADTKNFGEVFIFSYGVVVFWNFSEMQEKDILADLTFAENEMGVSLANCPLSDMEVETEEFHFEYSADINRPRVFNDMITLLPRSDHMVRLTISHAIAQSTKLCFFEERMSETMLSAQHVPKTLATTGNLNMTRGEIVKILGRLFKSRVDINLCSNILDVPNFFWDSEPTLHPLYVAIREYLEIDQRIKVLNERCRVFLDLADILADSIADSKMSNITVIIIVLIVVSIVVTVSEVVLRVALLKRGSGGHREGDLLLVGRGQRQRLELRGLPEVNASIEDLRLWGQSLSEGQKTAVCGSDVVGRTFAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2023-02-22" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDX8</accession>
    <name>G0SDX8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0053370</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695674.1">
        <property type="nucleotide sequence ID" value="XM_006695611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDX8"/>
    <dbReference type="GeneID" id="18259375"/>
    <dbReference type="KEGG" id="cthr:CTHT_0053370"/>
    <dbReference type="HOGENOM" id="CLU_1777218_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS18729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="146" mass="15097" checksum="01E1D73DF6987588" modified="2011-10-19" version="1">MTPDLPPRVAEHEEAFRGLTTASLATPVPQSTTGMPTAAVPATQGAGGGAIYVSLPATGTLAPAWIPQGMAPMGVGGDVSVLLPQQQQSGAGAPLPATMIVPSQQGYCVYFQPHVQAQSQGVVELPTQLQQLWTRVKLSEGRAELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G0SE08</accession>
    <name>G0SE08_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Carrier protein flx1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0062000</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696516.1">
        <property type="nucleotide sequence ID" value="XM_006696453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SE08"/>
    <dbReference type="STRING" id="759272.G0SE08"/>
    <dbReference type="GeneID" id="18260238"/>
    <dbReference type="KEGG" id="cthr:CTHT_0062000"/>
    <dbReference type="eggNOG" id="KOG0764">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_6_4_1"/>
    <dbReference type="OMA" id="TTVWKHE"/>
    <dbReference type="OrthoDB" id="428293at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006862">
        <property type="term" value="P:nucleotide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="10"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="121"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="235"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS18185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="331" mass="36684" checksum="7D2F50618528730A" modified="2011-10-19" version="1">MTDTKYAGLSPALVETVAGLSAGSMATLAVHPLDIVKTRMQVYRSTYTSSPTPLTTIAILRALLQTDRPVSALYRGLTPNLLGNATSWASFFFFKSRFERAIACIRSSATRDGQKRGNHRLTPLDFFLASLLSGIATQLLTNPIWVLKTRMLALDASAQGAYPSMLSGARQLLRDEGWKGFYRGLGVGMLAVSHGAVQFAVYEPGRRLWVAAAERVRRSRGTSESNREAALSNEATVVLSTVSKLVAGTVTYPLQVLRSRLQYHEAERVFGRGLRGVVGQLWREEGVRGFYRGLVPGVVRVMPATWVTFLVYENVKWYLPRWIGEREIRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0SE41</accession>
    <name>G0SE41_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0062340</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696549.1">
        <property type="nucleotide sequence ID" value="XM_006696486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SE41"/>
    <dbReference type="STRING" id="759272.G0SE41"/>
    <dbReference type="GeneID" id="18260272"/>
    <dbReference type="KEGG" id="cthr:CTHT_0062340"/>
    <dbReference type="eggNOG" id="ENOG502SMWI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_377220_0_0_1"/>
    <dbReference type="OrthoDB" id="4161595at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="591"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="688"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="482"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="720"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="735" mass="81110" checksum="61B3773DFAD3A984" modified="2011-10-19" version="1">MAEEVPREEYHRRLHGTHDTIDLTGDDRRPESPTDVVIRRHGNMSNGLSNLRFTQNNVAGTSGQGRQDALTTLHNFASAGLSNGHDNTPAEDLEEGAANVSPTANSVIQDVANTQVNHPYGLAAPPNFRYVQLNEPLPPIGLHGRSVAEIINAIDWSHPVYAGPNRVVFISRHVIEVAAQFVHDKDELEKEINIFVGTVCKFMDNCNLYSNTARIPWRKALSHFFGRNKKCTRQVPENVWIVMCRKHYQRARYRNTTEYNKRLIRLIAFQVLRIENWSESNRLGGTPQNGIVESWSLQPRRREQMRIDEARKRKLEDDEDVEDDEDEMDDLDVPTPATSGGSSQIPDWLLEMCRDGYSTIDILRIILEIKVRLDSGELTQIPDIEILPKISGDQSQPRSKPRTGRVSKGTSKDLGHRRTQSLENPSAGLYRRHANASRRSSQPNDASRHDAKRQRRDNYQDESYEDDFGTYVGRAAERPDTLRTLPSTSSNLPSLSYGGYGAGANGPLPAPRSNMYNSAATGSFANTRPSHQRTFSDVSNLPWENTVTYNTSATGYDHSTNGMQQEVLHGPSFSSTAYPQWPEIGYAPRTQGASYHQQHQAPTTSYSPQSFFPPLSTSTPGTGASHSRQPSSSYMNGYSSATGGNASSGAHGGFAACYNAGRGSYSGGAQSGFGAAYNLGATSSASGAQGPYGNTYNPVNGQGHNAGYMSSPAGAQQYDGFDRTVDDESKRFDRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0SE89</accession>
    <name>G0SE89_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0062890</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696597.1">
        <property type="nucleotide sequence ID" value="XM_006696534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SE89"/>
    <dbReference type="STRING" id="759272.G0SE89"/>
    <dbReference type="GeneID" id="18260327"/>
    <dbReference type="KEGG" id="cthr:CTHT_0062890"/>
    <dbReference type="eggNOG" id="KOG0810">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042423_0_0_1"/>
    <dbReference type="OMA" id="RWICFIL"/>
    <dbReference type="OrthoDB" id="10255013at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15849">
        <property type="entry name" value="SNARE_Sso1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF307">
        <property type="entry name" value="PROTEIN SSO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
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        <property type="entry name" value="T_SNARE"/>
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    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="9">
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            <begin position="246"/>
            <end position="308"/>
        </location>
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        </location>
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            <end position="195"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
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        <source>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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            <dbReference type="SAM" id="Coils"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGS18266.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
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    </evidence>
    <sequence length="349" mass="38893" checksum="97FEB9D4830EC249" modified="2011-10-19" version="1">MSYNPYAQGPSAESGYAYGQPEQHEMQPYGQQPSHYISSYDSPYSSQPAQQQQYGSMLDPVSSAGRSSSQPQQRAAAGDSVLSTTEFLARVESVRNDIRSLTGAIQQIASLHQQALASSDTTVATGPRAQLDQLVANTQVQNTSIRSQIQALKSDAERTTDGSFAIKKRQWESLNNEFKETIQKFLREEQQYKERYREQIARQYRIVNPEATEEEVQRAVDADWDDEGIFQQALRTNRLGHANAVLGAVRARHNDMVKIERSIEELLDLLQILNEQVLLQGQTLDQVAIKAEEATEHLGQANVQIEKGVQHARRARKLKWWCLGIVLLICIAIALGVGLGVALTKNATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEC1</accession>
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            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
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                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
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            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
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    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGS18298.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="802" mass="86968" checksum="686B02F494B19F6A" modified="2011-10-19" version="1">MNCKSCRKRKPLKDPASLKKQVPRLRRAKGTTAPKIRFSHLHHREVPHEALIDIYFSRFHDKPFHIFDESTFRQRLQLNQLPNYLLHALYAVAARCAPHPNGFQAAAKLSEQYSAQARREIDTDEPSVDALQALILLVTAFTAQGKGKKAYMLLTSAVGMAMALELHRELDINARVTSIERETRRRLFWTCYLLDRFLSCGSRRPCLISDRAILLRLPCWSPNPASLPIEGDFFQSYANFQHIQAGGKKHQGSSAMLIDICRILGITNQYLAAGGVKGDSHFPWHSLSNLSKIRQELDIWASGTEEVFSSLNSLFRRPDSTMLVLSKLIYHLIHCLIYRPFLPIDLAELAGSGQHQSWQIEATNLCFLHANAITELVELGRQAGSIEWPAFVGYCICTAGTVHIHGAHYSRIGNAGDMNVFASSADFLSREMQQLSELRLAWACVQHQRETLQQMYNAHSELVKSLAHNPMRYSPVFHLEDFFDRYSNMGGGSGGPSFSFDTANLGLCDVVLDFAPDTNPNQNQPPVYTSHLNQTSDPGPPRPSPLKRKSSMQSGRPRPELSCLLSLNNTAFNTPPTPAMSTPSSARRSMFATPTMPSQPSPSMMHSPTPLTSPHGLPQKVVGGFTANANNHPTPVPHNNGLGTTFGNAGGANSASTATPGFGLSASGNGSGTHHLRSPTTGPANGQGFDHGLFGGIPANTFSTTTPPGWNSSEDKPGGQVNNTTVGNINATGPSGSVSTTSDTSPATTADSTGTTGGPGEEKDPFLSLLEQLAENEGLLGGTGSDLDFFLTGTPAPPPGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEC9</accession>
    <name>G0SEC9_CHATD</name>
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        <recommendedName>
            <fullName evidence="5">DNA replication checkpoint mediator MRC1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0063300</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006696574.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0SEC9"/>
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    <dbReference type="eggNOG" id="ENOG502QSP5">
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    </dbReference>
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    <dbReference type="OMA" id="ERFNFRP"/>
    <dbReference type="OrthoDB" id="2130597at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Claspin"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF09444">
        <property type="entry name" value="MRC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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            <begin position="977"/>
            <end position="1119"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
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        <location>
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        <location>
            <begin position="1147"/>
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        <location>
            <begin position="59"/>
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        </location>
    </feature>
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        <location>
            <begin position="89"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="111"/>
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        </location>
    </feature>
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        <location>
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        </location>
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        <location>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="247"/>
            <end position="261"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="407"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="479"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="535"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="567"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="601"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="626"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="653"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="697"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="729"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="791"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="941"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="986"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1174"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1218"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1240"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1279"/>
            <end position="1291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS18306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1417" mass="157238" checksum="09482FB5BA879784" modified="2011-10-19" version="1">MASSPTSPKDISFSFEKRNPFLNYDVSSSESEVDESILRPRGKLASMMQVRGQQKDTAMEEDDEEDEDIVIAFRKPKPAQKAASTEEQQQQKEKHGDIERDEDEDVVVTSRPRKLLSRRQRTSASPEPQSPQKKFTINDDRAVTNSPPSRASSPGLFVSPSRPSRVGTPSRTQDNDNDNDNDNDNDNDNADDSDSSLPSPSALTKNPRFQALVAKKRAERLAREAEEAAKKASAQRHQQQKQNPQYGDEEDEENYDDITDDEGGRTLTQKSSRGRGQRKASKKAMEEMSRETQRLARSMQLVHEAKVKKKISKGVLFERFGFRPDDAQTSNVKEAEPHTQQQQQHQIEGVASSSRAASPAEGARLSTSDAEMRDANGEEDTPPSSPPEVGEPTEEKEGKGAAVQLDEGSDDSDEEFPEDPEAILQQRKKLNKGKGKATAVDLKAKEAAEVAKRTPAKRQIRVKLPILQANTAHTSAITIDDDDDDDDLQIQPPHPNPRVSDLFSRVPINQAKHPRPLQMLRLLAQLDDPDKKHPAANIPPAKQAQQPPPMTASELSATLLQRARQQAKAERDRHLEELRARGIHVQTAEEREKEEQEVEDLVEKARRQAEEIMRKEKRERRKNGENEEEDPPGWDSEEEEEEEEGEKEKEIELSGEEEDDESLVEEEAEKEEESKQPAGEDAEKADPDSDEEILPTARRKLRKPKAKTTTAVLSSDDEDGSSSLVKATPQPNKTIKSPVNNTATTSPAIPTSVLRSARKPFIPGLPVSGPAGMGLTQIFMGTMDDSQEGTPAPPLSPSQPKPTFDVADFADSNFSQRVSRQEDEDMILDSQPTIRRGAEEEETQGVQLDFKPATQVHGFESFLNQSPDDDDEMIDPTQDQGFSKLPKLKQRFVEVGAAEGLTQESVINTQEEDGRVHSSPLVRRTTGKLFRRGEFPPSTQPDDEEEEDEFGFGTKKADAFAAMKEAALKKKKKFDKKKSKAREMIEEQAEESEDEYAGLGGADDEVSTDEDDARDVQDMIDDDTRETEEDGRRLAAFYADRERRADEAQVNKLFHDITTGMLRRKRAAGDWDDLDDSDDDEARRRRMKRRQFAKMQRALFADERISKVAANPRNQAFLRTIEDRDSDEEMDFLFAPTPAPVAGVARLERQDSGMAVDGEDEDDVVPDSQPLPATNQPKPTVVTTTNPRRTKPITKRPSTLAEIRQTLSSLLEDDQHLRTSSSIIPETELASSSELEDNGDTVSESRPTSSSGSNKENLPSRRTKPGSGSSAIVDRLSLKRQSSSNSSTSRQAFTTTSGSPTRGPKVPTLLRRATTNSLLSNSATNSSSSSTGTTFIGVTTNPNATTSASKLFAAGAGDMKIKKVAGKRSGVSYLARENERRAALAEAERRREERKVVRGMEGRVEVVRGVLGRGSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEH3</accession>
    <name>G0SEH3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0063750</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696681.1">
        <property type="nucleotide sequence ID" value="XM_006696618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEH3"/>
    <dbReference type="STRING" id="759272.G0SEH3"/>
    <dbReference type="GeneID" id="18260413"/>
    <dbReference type="KEGG" id="cthr:CTHT_0063750"/>
    <dbReference type="eggNOG" id="KOG0335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1337373_0_0_1"/>
    <dbReference type="OrthoDB" id="8026949at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS18350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="205" mass="21715" checksum="F7C6208F5B025893" modified="2011-10-19" version="1">MSDCSDNIGTAVNGVTNGWDNAGANGASGGWDSPGTNGAAGGPNPHVDKFACKDCSLATGRPIVRSPAQLLTVECRNGNMGHFSRDCPQGGGDNRGCRNCGQEGHMARECPEPLNMDRVQCRNCDEFGHMRKDCLQPRDSKSLFLSYMPIIANCSKLLASSATTVVRWETTAATARMALLRMPTVVTTGFGNGATDANALLTDDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEH5</accession>
    <name>G0SEH5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sphingolipid delta(4)-desaturase</fullName>
            <ecNumber evidence="8">1.14.19.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0063770</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Delta(4)-fatty-acid desaturase which introduces a double bond at the 4-position in the long-chain base (LCB) of ceramides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = an N-acylsphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:46544"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:31488"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="EC" id="1.14.19.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.17" evidence="8"/>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696683.1">
        <property type="nucleotide sequence ID" value="XM_006696620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEH5"/>
    <dbReference type="STRING" id="759272.G0SEH5"/>
    <dbReference type="GeneID" id="18260415"/>
    <dbReference type="KEGG" id="cthr:CTHT_0063770"/>
    <dbReference type="eggNOG" id="KOG2987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032156_0_1_1"/>
    <dbReference type="OMA" id="GATCNQN"/>
    <dbReference type="OrthoDB" id="200948at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042284">
        <property type="term" value="F:sphingolipid delta-4 desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03508">
        <property type="entry name" value="Delta4-sphingolipid-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011388">
        <property type="entry name" value="DES1/DES2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013866">
        <property type="entry name" value="Sphingolipid_d4-desaturase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879">
        <property type="entry name" value="SPHINGOLIPID DELTA 4 DESATURASE/C-4 HYDROXYLASE PROTEIN DES2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879:SF8">
        <property type="entry name" value="SPHINGOLIPID DELTA(4)-DESATURASE DES1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08557">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017228">
        <property type="entry name" value="Sphnglp_dlt4_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01269">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingolipid delta4-desaturase N-terminal" evidence="11">
        <location>
            <begin position="35"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS18352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="391" mass="44718" checksum="F3B289B5879D028A" modified="2011-10-19" version="1">MARRNAAANGPSTAKGQSNSAENSGEKETVNLYDPKLHDFIWTYTEEPHRTRRLAIIKAHPEVTKLCGHEPLTKYCVAFVVGLQVLMAHLLRDTPFWSWKFWLVAYVIGATANQNLFLAIHEISHNLAFRSPLANRLFAIFANLPIGLPYSASFRPYHLTHHKSLGVDGLDTDLPTALEAVVLDSILGKAFFCTFQIFFYALRPMAIYRVPFTWVHYLNILVQFAFDYAMIYLLPGYFTLNSFKYLLLSSFLAGSLHPTAGHFIAEHYVYETIPPEARDPKNMIPVPETYSYYGPLNWVTYNVGLHNEHHDFPAVPWTRLPKLYEIAKEFYEPLPQHTSWVYVLWRFIFDPTVGMKCRVKRKMGGRVVGGGTAVPVAKQADWKDDEVEARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEH6</accession>
    <name>G0SEH6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0063780</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696684.1">
        <property type="nucleotide sequence ID" value="XM_006696621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEH6"/>
    <dbReference type="STRING" id="759272.G0SEH6"/>
    <dbReference type="GeneID" id="18260416"/>
    <dbReference type="KEGG" id="cthr:CTHT_0063780"/>
    <dbReference type="eggNOG" id="ENOG502QWIY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016622_2_0_1"/>
    <dbReference type="OMA" id="NQPEFYT"/>
    <dbReference type="OrthoDB" id="3365616at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22952">
        <property type="entry name" value="ART10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF166">
        <property type="entry name" value="ARRESTIN (OR S-ANTIGEN), N-TERMINAL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G02050)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="459"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="484"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS18353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="600" mass="65637" checksum="C145FAA177F03B05" modified="2011-10-19" version="1">MSIRIILENPPEFYTNLDVIRGQVILNLSRHESVSAVVVKLEGESRTALGVPNDIPGLGIARDRGGHQNNSSDVVHENHKILYKVLQVFPDERTPAVNQPTILNPGQHHFPFEFKFPFNNVCSNPELMSRIGGLVNPGGYGSGGLFGFSGPRVMDGTKQLLYQHVTRTLPPSFTGFPGEAEIRYYLKVTVQRPGIFKENWRYELGLKFLPIEPPRPPKTNQEAYARRPYTFQPRALPTPTQPRKRSGFFSWGSNSSSDLNLQTSSASSGPPPSIEMSARLPHPAILTCNKPIPLRLIAKKLVPSRAEVFLTNLEIDLVGKTNVRCRHLINTEISRWVVVARHGLAIPVSKPDDAVGTEVLVPNSLWSDVPLPNTVMPSFVTCNLSRDYQLELKIGLSWGRPQPQSPHFKGKNRLDVSSLSQELHLPLHFSRIEVYSGLTPPAALAEAAVRNNGRPKPQPSSRPAAASPAQAQAQAPPLPPRRPVPASQAQSQSQSQSQPQPSPSTSTQPQPQPQSPTQGQDQENLPAYWPPEPPYDDAPPTYEEAMAEMMTGPMFPAQARPAYSGVTDVNGPSTLPDGDAGNTQGRTEAGAVGGGRSEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEX1</accession>
    <name>G0SEX1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0060000</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS17987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696318.1">
        <property type="nucleotide sequence ID" value="XM_006696255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEX1"/>
    <dbReference type="GeneID" id="18260038"/>
    <dbReference type="KEGG" id="cthr:CTHT_0060000"/>
    <dbReference type="eggNOG" id="ENOG502T3ZS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_438705_0_0_1"/>
    <dbReference type="OrthoDB" id="2873061at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587:SF4">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="452"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="623" mass="66967" checksum="265C9FA005CF60B5" modified="2011-10-19" version="1">MYIYDYPTGLLMPSPALHQAAASYSKPAALILQLISRLWQPRPDDNTPARSYSPAPYSSGNSYYRYSHRRTSTFPASGSDVPRKPVPLVFRLPVQVSSSSSSTSSAAQPVSFPSRPRANTAPPGAEQQQERTLRPTQPLLSSSPPQEPGRQSPPRGHKRTGSRTVFTSASKARPLRLVQDALNRKRRPPVFFAQSNRSLLQSVTYITIHQQLEHLTQELQDTLDKMANPNPILPKVVPLSSLPSNPRPPVPMPAQVDKEKIIADLRRQLDDSASEASSVDSRGRRRRRNKNNQLAQAGMGALPTPSILPRLADTKPVRLQLGLNLDVEVELKARLQGDVSLTLLIESTPSTPPPHATVLTCPRPDAPTVTHPDNLFFMRLGRLSFRPSGPGWWLPHLGFAPQSGGWEGAMPGGRVAWFPPWYDDPTNDDDKDQDQESSHGRKDYHGGNGPSVWTVACVVLLAVIVGFVLGFGSAVWLVSSLPVSPYFSFPSSFHSASSPSAAAFSSTPTPSPSVTVVKGLASRAAIWGLSTSWEELGSGFGNRLNGVTTASTGTFGYGLGHGVLDLGLLGMDLDLGLGSGKGWLASASSLAGVVEGDVVGFGLGDLLRDVGASLERQLGFVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G0SF33</accession>
    <name>G0SF33_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0060640</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696380.1">
        <property type="nucleotide sequence ID" value="XM_006696317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SF33"/>
    <dbReference type="STRING" id="759272.G0SF33"/>
    <dbReference type="GeneID" id="18260102"/>
    <dbReference type="KEGG" id="cthr:CTHT_0060640"/>
    <dbReference type="eggNOG" id="KOG2431">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003818_0_0_1"/>
    <dbReference type="OMA" id="CAWAYEA"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF89">
        <property type="entry name" value="ALPHA-1,2-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="96"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="535"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="703"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="538"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="706"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="728"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="521"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="608"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="696"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="478"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS18049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="743" mass="83153" checksum="BB2F15B729AC9E39" modified="2011-10-19" version="1">MRKLGSPRQDPSAPKHYFIGRSASRARHVKRHDQPHLNALTAAIILFNSISTAAPQWAGFSPMAIFPARRRFVRLALTTVLFLTVYLFFAQPPALHPPPPPPPRGHHHSQEKNHAGAPEKPAYKPTSFDWASRPVAHPLDDSEIGRLPEGEPLALPQIQHAFTTTELTASHNETQRKRREEVRDAARRAWNAYKKHAFGRDELTPLTLSSRDTYAGWGATLVDSLDTLWIMGLKDEFYEAVGMVGKIDWNKPRSNICSLFETNIRFLGGLLSAYDLSGEEVLLRKAKELGDMLLAGFDTSTHMPTNSFDISLARKGRLVPSFSESLAAAGSLSLEFTRLSQLTGDNRYYAAVNHVTRALARAQEKTALPGLWPVFIDLRSPLLTAGNTFSLGASADSAYEYLSKMYILLGGRGDVYEKLHVDAMQAAARYLLFRPMPPPPGKGSSSDSIPLEEVLFTGTAYVSGHTYTLRPEVQHLGCFAGGMFALGGRLFSLPGHVQIGKQIALGCAWAYSRFPTGIMPEVSLLAPCDGAGMSKTVDDDDDDDDDNGAVSKKKNVTSPEDVPKCEWNQAKWEKLLRQQGSSADKDDELRLPKPWTSVKDPQYLLRPEAVESLFILWRVTGDAAMLDRAWEMWQSVKDATEVKDNGAFAAIRDVRIRRGEWQDSMESFWIAETLKYFFLAFSDPDVISLDDYVFNTEAHPFRIPKPRREDGPVKGFENRDRGQETHQQHQQQQHQQQQQQQVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFF4</accession>
    <name>G0SFF4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0061850</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPO2/CSE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696501.1">
        <property type="nucleotide sequence ID" value="XM_006696438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFF4"/>
    <dbReference type="STRING" id="759272.G0SFF4"/>
    <dbReference type="GeneID" id="18260223"/>
    <dbReference type="KEGG" id="cthr:CTHT_0061850"/>
    <dbReference type="eggNOG" id="KOG1992">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009614_0_0_1"/>
    <dbReference type="OMA" id="AENEFLM"/>
    <dbReference type="OrthoDB" id="3268246at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005043">
        <property type="entry name" value="XPO2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF8">
        <property type="entry name" value="EXPORTIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03378">
        <property type="entry name" value="CAS_CSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="24"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS18170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="958" mass="108513" checksum="3B730661E02C4650" modified="2011-10-19" version="1">MASSLDLIAGLLNQTLNAQTHREAENKLKEEAKKPQYSLSLLKIVSNAAFQTNTRLAAALAFKNFIRHNYVDEEGNYKLPLDEVQTIKQELVGLMISSPPSIQTQLGEAISIIADSDFWERWDTLVQDLVSRLSDTDYKVTNGVLEVAHSIFVRWRPLFQSNDLNREILHVVEHFGEPFIKLLDLADRQIQANGTNVAALKGWLETMSLLVRLLYDLSCQDLPPVIETHLQPISLLLHKYLVYKYQTDEFDDEEDTATPLETLKADICDVLQLFTNKYDEDFGHLVPEFANDVWGLVSNLDEKTRYDILACKGMQFLTAVASVRRHAEAFNNHSILNEIVLKVVIPNVKLRESDLDMFAEEPIEFIRRDLEGSDSDSRRRAATDFLRKLLENFEDLVTQVVFVHINQYLEKGRTDFKDKDTAVYLFLAIAAKGAVTASHGVKTVNSHVDIVQFFEQHIAADLLANTQHAISKVDAIKYLYTFRSQLNKAQWTAAMQPLIQNLASDNYVVYTYAAIAVERVLFLTDEQGQHLFPRSDIQPFAKDLLEHLFKLIEKDTSAPKLQENEFLMRCIMRVLIVMKDGIIDSGIESVLNHLIQITNVIRENPSNPRFYYYHFEAIGALVSNSPRVDLLAHLWEPFSYILDKDISEFVPFVFQIFALLLELNPSGHVPGTFKVIIQNILAPNWWEQRGNVPPLSRFIAAVIPRAAEEIKAGGKLETFLGIFQRLLNGKKTEQNAFDVLEAIVGTFDGEILEPWFKEIIALVFTRLQANPTDSLKQRVARFYHLVSARGIEAKMGADYFIRHAESIQANVFTPFYLTVILPTTGQFARPVDRKLGVISYSKTLGDSEAFANRYQKGWGFTCNHLLDLLKNPPRVTAGFGDEIVNEADVDDIGFGVGFTPLNTCKRGPRDDFPDVLEVEKWVSAYLKDANVRHGGKIAGFVESRLTPEAKAALVPYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFH7</accession>
    <name>G0SFH7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0070870</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697360.1">
        <property type="nucleotide sequence ID" value="XM_006697297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFH7"/>
    <dbReference type="STRING" id="759272.G0SFH7"/>
    <dbReference type="GeneID" id="18261125"/>
    <dbReference type="KEGG" id="cthr:CTHT_0070870"/>
    <dbReference type="eggNOG" id="ENOG502QQZ5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_933840_0_0_1"/>
    <dbReference type="OrthoDB" id="342264at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS17742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="34493" checksum="C96D9553519FD238" modified="2011-10-19" version="1">MPNTCPHMVKVLKVRKALKLRRNIVTLDWLKDSMHMCKCLPEEPFSHVAAVKKQREREKRRARLQKGLEEEKRAVNTNLYRIYRDQTFFRYAVVITRDDEENGIVGERYILMLFESLAQPKLYWFLAKYYRKKGDTQAKFYRPSQSPGIFERGYALFKLFFFKKTGVNWDERLIQEKKRGEEGNVDGEDNGMAVVGNADQEGVTVKPKQRRVTFTYTPPTGGKPLGWVPAQFLSPEMPKLEPEPKLVSNLNGAVVVISRDDDDDDDDDNIDEKYERELRDVDITMVDVDCAGKGGEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFX8</accession>
    <name>G0SFX8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0072520</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697511.1">
        <property type="nucleotide sequence ID" value="XM_006697448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFX8"/>
    <dbReference type="SMR" id="G0SFX8"/>
    <dbReference type="STRING" id="759272.G0SFX8"/>
    <dbReference type="GeneID" id="18261290"/>
    <dbReference type="KEGG" id="cthr:CTHT_0072520"/>
    <dbReference type="eggNOG" id="ENOG502RVZM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035914_0_0_1"/>
    <dbReference type="OMA" id="CLMKLPP"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF125">
        <property type="entry name" value="N-ACETYL-6-HYDROXYTRYPTOPHAN OXIDASE IVOB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409197" description="Tyrosinase copper-binding domain-containing protein" evidence="4">
        <location>
            <begin position="21"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="5">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS17893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="419" mass="46670" checksum="FCE20C1C789400EE" modified="2011-10-19" version="1">MRPLNTFTTLSLFLLGGISASPTPPTKRWDFNPSRNPAYQLDIVDQLLVNTMPKVESWMSLKNATNGCTLEKAAIRREWSDLSVPEREEYIRAVLCLQSLPSKAPKDQVPGARSRFDDFVATHITQAFDLHSPRKLFAAHRYFIWAYEKALREECGYTGYQPYMNYERYADDPLNSPLFDGSPSSMSGNGLPEPYPGVPQGFPRPYNMIPPGDGGGCVTTGPFKDMVVNLGPRGGVLPNLPRNPRADGLGYNPRCLRRDVNKNSVAGARANYTYSLIMDHPDVDSFYNRYLGQPFLRGDPYPWGLHSAGHYLIGGDPGGDFYCSPGDPLFYFHHGMLDRVWWIWQMQDPENRVNAVPGEPDTWGPGDGSGHIHGKRQGSGSSSVWEDVIDLGWTAPPVKLMDLNDQLGGLGGELCYIYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFZ9</accession>
    <name>G0SFZ9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GmrSD restriction endonucleases C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0072740</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697532.1">
        <property type="nucleotide sequence ID" value="XM_006697469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFZ9"/>
    <dbReference type="STRING" id="759272.G0SFZ9"/>
    <dbReference type="GeneID" id="18261312"/>
    <dbReference type="KEGG" id="cthr:CTHT_0072740"/>
    <dbReference type="eggNOG" id="ENOG502QWPZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043034_3_1_1"/>
    <dbReference type="OMA" id="ASYYCTY"/>
    <dbReference type="OrthoDB" id="3162605at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011089">
        <property type="entry name" value="GmrSD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24094:SF15">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24094">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07510">
        <property type="entry name" value="GmrSD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409128" description="GmrSD restriction endonucleases C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="GmrSD restriction endonucleases C-terminal" evidence="2">
        <location>
            <begin position="103"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="204" mass="22361" checksum="D689F84370654761" modified="2011-10-19" version="1">MKFVTIFSLLAAVVSAAPAPQPTPPGIPSRSTAQSYLNSLTVAASYDDGNYNRDLFPHWNTVSGTCNTREYVLKRDGSNVVTNSACQATSGTWYSPYDGATWTAASDIDIDHMVPLKNAWISGANTWSSSKRSSFANDINSPQLWAVTDSVNQSKGDKSPDKWKPPLTTFYCTYAKSWITVKYNYNLTITSAEKSALQNMINTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGM6</accession>
    <name>G0SGM6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0066880</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696983.1">
        <property type="nucleotide sequence ID" value="XM_006696920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGM6"/>
    <dbReference type="GeneID" id="18260726"/>
    <dbReference type="KEGG" id="cthr:CTHT_0066880"/>
    <dbReference type="eggNOG" id="ENOG502S342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048444_1_0_1"/>
    <dbReference type="OMA" id="APVTCLW"/>
    <dbReference type="OrthoDB" id="2152248at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS17365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="36374" checksum="1DE7C3FE38238B06" modified="2011-10-19" version="1">MESVPLPPAPKISVVTLTLGPSSLLVDVHGLEELPASTETISCLWLHHPRLQTRAYMADIAARCISAWNERQEETKSKRGLIALAWDQPNHGSRLTDPKKNDSWREGNETHAEDMFASIVQMVRDQKGLLDSIDALLAEKAPGKKADQHLALGVSLGGHSVWQTMFAEPRVTADLLTDRARLTKLSTYTVDSGASFLGSQHFPTSLVQSCLENDPKGIFFGTSPVPDTSVPADAKAHKILHDRLRGKKFLLCSGGADKLVPYRCAEPFLTWFKQLTGNWYPEEGVLVDDRVYEGVGHSFSADMVRDSVRFVLEVMSEAEKSAARGASPSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGU3</accession>
    <name>G0SGU3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0067580</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697050.1">
        <property type="nucleotide sequence ID" value="XM_006696987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGU3"/>
    <dbReference type="GeneID" id="18260796"/>
    <dbReference type="KEGG" id="cthr:CTHT_0067580"/>
    <dbReference type="eggNOG" id="ENOG502R99U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_520733_0_0_1"/>
    <dbReference type="OMA" id="EHIMKAN"/>
    <dbReference type="OrthoDB" id="4590361at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="84"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="523" mass="60195" checksum="66A95F463CDC43C2" modified="2011-10-19" version="1">MKTSPTSSNQVPNFSSSYAPLTPACKEIRLLWLIVPIKEQTSAPKSCCSVETSNNTFSNEDDSGDDIPIHTTLETVSLLDNPAYMALSYTWVDPFANYQPRSSRKPYILLNGQHVEVRPNLYDFFRNMQRHIQTGSCDNPCGHHLRSLLRRLAQEGSEEKGVVRLPLWVDALCINQSDILERNSQVMLMGDIYRGAAAVISWLGEHRKLTRGLRTISELARRWRGYVEEIEQKKKYRKRSRREEDTSPPMAERDAKPEAVPGLDEQVIQFMRSTRDIWHNEQTLISLLRVFHTKYWRRIWIVQEMVLANPESHIFMTGPGPHMASISDMRVMIICLTNFWRLLTSSITTVANEGNQEDEEKRDVLIMWKLKDTISFEVYQWWVLHKLQRGEQTPSLMFVLNTAFGHDTTEPLDAVYGLLNLLPPDCGIVPDYQRSVRDVYIDWAVRTMRECGNLNLLTWIWSKKKSGPDFGLPSWVPDLFNSKSRIEMRDSDWDKPKGPKNTRNDSSSSRPALFGSVSAVMAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0SH91</accession>
    <name>G0SH91_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0069150</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the GSE complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697198.1">
        <property type="nucleotide sequence ID" value="XM_006697135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SH91"/>
    <dbReference type="STRING" id="759272.G0SH91"/>
    <dbReference type="GeneID" id="18260953"/>
    <dbReference type="KEGG" id="cthr:CTHT_0069150"/>
    <dbReference type="eggNOG" id="KOG3886">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044099_0_0_1"/>
    <dbReference type="OMA" id="QQKDHIF"/>
    <dbReference type="OrthoDB" id="10020193at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11384">
        <property type="entry name" value="RagA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.190:FF:000002">
        <property type="entry name" value="Ras-related GTP-binding protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002028">
        <property type="entry name" value="Related to GTR1-GTP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039397">
        <property type="entry name" value="RagA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF1">
        <property type="entry name" value="RAS-RELATED GTP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="422"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS17580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="459" mass="51152" checksum="018E887383B884D8" modified="2011-10-19" version="1">MEDHQQPPLSNPTIHRGRSDLDHESLSKLFGKLLNELTLTMSDFDAAMGASPAVPSGPDVLGLAAPHALKKVKKQKVLLMGKSGSGKSSMRSIIFSNYLARDTRRLGPTIDVDLSHVKFLGNLTLNLWDCGGQEAFMNNYLSQQRAHVFSNVGVLIYVFDIESREVERDLATYINIISALVQYSREAKVFVLIHKMDLIQPVTREDVFEKRAVLVKRKTAEAVAIMRKQQQHQQSQSPQSPSNPVLDIDLQLFATSIWDQSLYKAWASIIHDLVPNLSVIETQLASLGMAIDADEILLFERTSFLVVSKWTSREGERNPYGDRFERMSNILKSWKHTCSKYTGTPRNAEQFSEFEYKMGTTFSMFATKFTTNTYILVCMPPGEARFNAAKLNVAAARPWFKFLDGPVTVAHSAMSSHQQQHIPVGTPTSAVNSSNGNGGPSDSGTTVPEYFMANKDTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHC6</accession>
    <name>G0SHC6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0069550</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697233.1">
        <property type="nucleotide sequence ID" value="XM_006697170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHC6"/>
    <dbReference type="STRING" id="759272.G0SHC6"/>
    <dbReference type="GeneID" id="18260993"/>
    <dbReference type="KEGG" id="cthr:CTHT_0069550"/>
    <dbReference type="eggNOG" id="ENOG502S4JN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095059_0_0_1"/>
    <dbReference type="OMA" id="PHNDGEE"/>
    <dbReference type="OrthoDB" id="5344687at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42089">
        <property type="entry name" value="YALI0F09427P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42089:SF1">
        <property type="entry name" value="YALI0F09427P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="175" mass="19227" checksum="F836DBD28D2253D7" modified="2011-10-19" version="1">MHDTKTHPLLQQLPLTVSPFLNLPTAPTLPYTYKPMPSTLPPSILTPPPPETQPHPSSSSSSSSSSSSGSQSLPKYVTSPGGTHSAHPSEIISSCRALQSHLSKLQSQGERELEEFEERIRKRELAEKRRIAPGWLDSEVRVLQPERVNKGDEKEGGKDEGEELDRVFGLLEVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHP9</accession>
    <name>G0SHP9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DUF1640 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0072940</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CCDC90 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS16969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697551.1">
        <property type="nucleotide sequence ID" value="XM_006697488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHP9"/>
    <dbReference type="GeneID" id="18261332"/>
    <dbReference type="KEGG" id="cthr:CTHT_0072940"/>
    <dbReference type="eggNOG" id="KOG3156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063283_2_0_1"/>
    <dbReference type="OMA" id="MAYMRFR"/>
    <dbReference type="OrthoDB" id="889336at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000018">
        <property type="entry name" value="Mitochondrial protein FMP32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024461">
        <property type="entry name" value="CCDC90-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360:SF1">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07798">
        <property type="entry name" value="CCDC90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS16969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="26792" checksum="29F80601D2A5D728" modified="2011-10-19" version="1">MQKFYSTLPAASPELDEPIVDHWDPAESVGGVRRLSSITPSPELRRSFHVSAARQRDHHFDTLRFVQRLQAEGFTEEQAVALMRVLNDVIEESIQNLTRTMVPREEAAKITYTQKVDFAKLRSELLSADSTEHNTTRATHEKLTNDIAKLSSRLRDEIGRTQASVRLDLNLEKGRIREEAVSQELKIKETETKIEQEAAALRQQLEQVKFQTLQWLIGVCTGFAALLLGAWRLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHZ9</accession>
    <name>G0SHZ9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Monooxygenase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0073970</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697651.1">
        <property type="nucleotide sequence ID" value="XM_006697588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHZ9"/>
    <dbReference type="GeneID" id="18261435"/>
    <dbReference type="KEGG" id="cthr:CTHT_0073970"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032067_2_0_1"/>
    <dbReference type="OMA" id="GPWYGRV"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051820">
        <property type="entry name" value="FAD-binding_MO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43872">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G02570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43872:SF1">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G02570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS17069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="503" mass="56814" checksum="89EB57256FBD9C9A" modified="2011-10-19" version="1">MTAEAEPAEEFDIIIIGAGLSGINAAYRVQKELPHRSYAILERRHEIGGTWSFWKYPGIRTDSAMGLFGFPWRPWPYDNNMATAQAIRTYMEECAASEGIDRHIRFGHRVASAAWRSNEQRWTLTVVVTHKDGSVATKTVKAWWLICASGYYSYDKPLPAVIPGLENFEGQVIHPQFWDESINYDGKRIIIIGSGATAITLLPALAKTAQSVTMLQRSPTYVMSLPRRDSTLQLLCRFLPRSWAAAINWWNRMIIETLFVKFLLTFPNISRAFLMSEMRRQLPAGFDVETHFNPRYNPFQQRLCFCPGGDFFKALHRPNARVVTDIIDTVTATGIRLKSGAFLEADMIVTATGLYFNLFDGLDITIDGELLRDSIADRYIWNGSMLEGVPNAGLIVGYTAATWTPGADVRVRQMIKVMKYMERSGAVEARPWLDPKKKAKLPANPAVDLTSTYMVTAHNRMPRNAGKGPWMNGASWAADVFRLWFGSVRSGMRYVFAPKDKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G0RXS2</accession>
    <name>G0RXS2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0000190</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988030">
        <property type="protein sequence ID" value="EGS24088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690574.1">
        <property type="nucleotide sequence ID" value="XM_006690511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RXS2"/>
    <dbReference type="GeneID" id="18254057"/>
    <dbReference type="KEGG" id="cthr:CTHT_0000190"/>
    <dbReference type="eggNOG" id="ENOG502RM6Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_454137_0_0_1"/>
    <dbReference type="OrthoDB" id="4589628at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="147"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="534"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="404"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="154"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="539"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="582"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS24088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="601" mass="69196" checksum="D1EFB65BC33553CD" modified="2011-10-19" version="1">MKEVLHDPQFTTPVPQQAKNDETEQEHIVRVVKNNLAVIFKAMLHSEDSYMAQNFWERVSICSHGRGTQVSSTISELFIEARRTYTSRFGDSIINGATIYVDQWIELVDALASGHDPRNKSRKAWTTKFREWTEKRQKGELENLADKVEHDLSSRPQYTQRRGMSGSQNGRRPAVSHDNAEGSQNSDSDSDSEVVVVSERKCERYPAQINDKGKRKTVETAEEVTTRPIKRRADRYHHRALTTPPQSSPPSGHNRSRKHNNNNNNNNNEEEDDVNDTWEGPSGSPAARRCATRAAARTIDDSDVENPSHHRDNNNSNACPSEHNQQEEIKVLKTSVLQLHNRERNRGKYMTTLARKTVKKEFADFLNDHNGELKSHKELTQQVTKLQGRVEAREKHDDKQGKMLKDLKNTVNDQLEDYKALAEKVEVLEATTKEYEQQIEALTEEIKALKNAEFSTDSGSDFEPDSSNDKKTAANATVTWQEFQKIKNILNNHEKEFERRLKALEKTLCERYEKIIRDLEKENAELRNMLAQQNQATVQSNQNGQQDQQVPQRQQNNNGGRQAQNGHQHQIRNQNNRGNNNVRFQSYQCNSSRFNQKRLNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0RXW7</accession>
    <name>G0RXW7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short-chain dehydrogenase/reductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0004550</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690995.1">
        <property type="nucleotide sequence ID" value="XM_006690932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RXW7"/>
    <dbReference type="GeneID" id="18254493"/>
    <dbReference type="KEGG" id="cthr:CTHT_0004550"/>
    <dbReference type="eggNOG" id="KOG1201">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_5_1_1"/>
    <dbReference type="OMA" id="NWYAVLP"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05339">
        <property type="entry name" value="17beta-HSDXI-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="91"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS23753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="363" mass="39564" checksum="BAC328C97038E5E0" modified="2011-10-19" version="1">MDPRPIPPQRDSWFAPLSIDLLVKVLKTTFFHPFVAWIIPLCFRAQNLPWDAPKTLAAIVWASFISLCWVANVVNQRIAYGLPREVDLSEEVIVITGGASGLGLLIAEVYGMRGATVAVLDVEEMENGEARGVTYYKCDVTDKEQVAKVAAQIERDLGTPTVLINNAAIVIGKSLLSMSFDEVEKSLFTNLISHFYTLKTFLPALARNENGGTIVTISSVIGHLGAARLTDYAAAKAGITALHKSLTAELAQTHPNIRTVLVTPGQLSTPLFYGVQTPNAFLAPVVEPVDVAKEIIAAIDGGRSASVSMPLYARWVDWYNVLPASLQRIARRLSGIDTAMKTFVGRNGFKLQKEKKEVAIQAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G0RXY1</accession>
    <name>G0RXY1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier protein (Pet8)-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0004690</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691009.1">
        <property type="nucleotide sequence ID" value="XM_006690946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RXY1"/>
    <dbReference type="STRING" id="759272.G0RXY1"/>
    <dbReference type="GeneID" id="18254507"/>
    <dbReference type="KEGG" id="cthr:CTHT_0004690"/>
    <dbReference type="eggNOG" id="KOG0768">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_3_0_1"/>
    <dbReference type="OMA" id="IGPRTMW"/>
    <dbReference type="OrthoDB" id="276989at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000112">
        <property type="entry name" value="Mitochondrial carrier protein (Pet8), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="9"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="98"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="230"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS23767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="322" mass="34668" checksum="386A6364C61F651D" modified="2011-10-19" version="1">MAPSELPPPPFQTALLAGAVAGTTVDLSLFPLDTLKTRLQSAEGFFASGGFRGIYRGIGSVVVGSAPGAAFFFCTYETTKGLMLSYSTSGEDEYTRKKHAAITHMVAASAGEIAACAVRVPTEVVKQRAQAGQHGGRSWDALSHILRGNGDRKSVGVVKRACTIWRELYRGWGITVMREVPFTVLQFPLWEALKAWGRERKARTGRGLLGEGAGSSQKRDVDGRMIEEEVSAPESALYGSLAGGFAAAATTPLDVLKTRVMLSKERESITSIVRSIWREGGVRSFFAGIGPRVMWISAGGAIFLGSYQWAVNMLDRRDKGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>G0RY23</accession>
    <name>G0RY23_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0005130</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691051.1">
        <property type="nucleotide sequence ID" value="XM_006690988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RY23"/>
    <dbReference type="GeneID" id="18254551"/>
    <dbReference type="KEGG" id="cthr:CTHT_0005130"/>
    <dbReference type="HOGENOM" id="CLU_1467980_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="184" mass="20077" checksum="53938F372919EA54" modified="2011-10-19" version="1">MAPVERIKNNGESKDPQPNNTKNLQTTSNPEVIVDAEPASTTPPSPDSSSNYTTARSSLSLPPNFRVAAKDDRAESVLRFGPARARTVEPVARATSPFANINTPQRPASTPAGGNWHIRHRRQQQQSATSQKEPAVRPNRFERAHGNLTVPSLPTQQGDATSEQRERRTEPHEQPEFGNGAGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYG1</accession>
    <name>G0RYG1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0006570</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691189.1">
        <property type="nucleotide sequence ID" value="XM_006691126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYG1"/>
    <dbReference type="STRING" id="759272.G0RYG1"/>
    <dbReference type="GeneID" id="18254695"/>
    <dbReference type="KEGG" id="cthr:CTHT_0006570"/>
    <dbReference type="eggNOG" id="KOG2450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_0_0_1"/>
    <dbReference type="OMA" id="GQLIMQY"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019413">
        <property type="term" value="P:acetate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07091">
        <property type="entry name" value="ALDH_F1-2_Ald2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000050">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000001">
        <property type="entry name" value="Mitochondrial aldehyde dehydrogenase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="123"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS23947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="590" mass="64024" checksum="7404D9E19234C5FF" modified="2011-10-19" version="1">MRLVHTPSLGRALCRPGPNKLSRGYLQSSFWEAGRGSRPIVHKAARPRSHPAAFVPVSRTLNPGWLQLKHQNSSITAPIATTITSSFSTSAKMSSDLFVELSTPVTGPYKQPIGLFINNEFVEGIEKKKFEVVNPATEEVIVSVCEATEKDVDVAVAAARKAFEGVWRRVTPQQRGLMLLKLADIAEKNAELLAAVESLDNGKSITMARGDVAAVVGCIRYYGGWADKIEGKTIDINPDMLHYTRPEPIGVCGQIIPWNFPLLMLAWKIGPALATGNTVVLKTAEQTPLSALVFAQFIKEAGFPPGVVNIISGFGKTAGAAIASHMDIDKVAFTGSTLVGRSIMKAAAESNLKKVTLELGGKSPNIVFDDADIEEAISWVNFGIYFNHGQCCCAGSRIFVQEGIYDKFLEAFKKRAEQNKVGDPFHPETFQGPQVSKLQFDRIMGYIESGKADGAKIVTGGERHGDKGYFIKPTIFADVRPDMKIMREEIFGPVCAIAKFKTIEEAIQMGNDTCYGLAASVHTKDLNTAIRVSNGLRAGTVWVNCHNMLSHQLPFGGFKASGIGRELGELALANYTENKSVAINMAGKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYH6</accession>
    <name>G0RYH6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0006720</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691204.1">
        <property type="nucleotide sequence ID" value="XM_006691141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYH6"/>
    <dbReference type="STRING" id="759272.G0RYH6"/>
    <dbReference type="GeneID" id="18254710"/>
    <dbReference type="KEGG" id="cthr:CTHT_0006720"/>
    <dbReference type="eggNOG" id="KOG1137">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009673_2_1_1"/>
    <dbReference type="OMA" id="CKQHITL"/>
    <dbReference type="OrthoDB" id="10249535at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16292">
        <property type="entry name" value="CPSF3-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000001">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10890:FF:000004">
        <property type="entry name" value="Cleavage and polyadenylation specifity factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021718">
        <property type="entry name" value="CPSF73-100_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF11">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11718">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01098">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="12">
        <location>
            <begin position="36"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="13">
        <location>
            <begin position="262"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term" evidence="14">
        <location>
            <begin position="548"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="694"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="763"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="699"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="719"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="786"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="806"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS23962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="894" mass="99121" checksum="35E9DB54CD1C3960" modified="2011-10-19" version="1">MASKRKASQMAAAPEEPVDPSDELMFLCLGGGNEVGRSCHIIQYKGKTVMLDAGQHPAYDGLAALPFFDDFDLSQVDVLLISHFHIDHAASLPYVLAKTNFRGRVFMTHPTKAIYKWLIQDSVRVGNTSSNPTSQLVYTEQDHLNTFPMIEAIDYYTTHTISSIRITPYPAGHVLGAAMFLIEIAGLNILFTGDYSREQDRHLVSAQVPKGVKIDVLITESTYGIATHVPRLEREQALMKSITGILNRGGRVLMPVFALGRAQELLLILDEYWAKHKEYQKYPIYYASNLARKCMLVYQTYVGAMNDNIKRLFRERMAEAEASGDSAGKGGPWDFKFIRSLKSIDRFEDVGGCVMLASPGMLQNGVSRELLERWAPNEKNGVIITGYSVEGTMAKQLMQEPEQIQAVMTRSSAGGRRGPGGESEKVMIPRRCTVQEFSFAAHVDGNENREFIEEVGAPVVILVHGEVHNMMRLKSKLLSLNANKTNKVKVYSPKNCEELRIPFKTDKTAKVVGKLASIPQPLKMPKFDAAAADGSTTITAAATGPDSEPRIVTGVLVQNDFKMSLMAPEDLREYAGLTTTTIACKQRLRLTAAGIDLIKWGLEGVFGRVEELPEGKPRPTKEANGEGEDTKMVEAADEEYPLNEVVAAYNVMGCVTVRCWTNGEVEIEWEGNMLNDGIADAVMALLMGLESSPAAVKRSSSKHTHTHTHSHSHSHSHSHSHDHDHDHDRALPIRNPHANLDPSERLSRLMLFLEAQFGADNVSPVAEPKIPPLSPRIRARKKKAVSPPAESTPAPESESEPAPKEEEPEEEESEYDTDEEALDLARRTEEAKARELARLHKLGIPVPGVRIKIAEKMQATVWLETLEVESENKVFKERVRAVVERAVECVAPLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYL2</accession>
    <name>G0RYL2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CTHT_0007090</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691240.1">
        <property type="nucleotide sequence ID" value="XM_006691177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYL2"/>
    <dbReference type="STRING" id="759272.G0RYL2"/>
    <dbReference type="GeneID" id="18254747"/>
    <dbReference type="KEGG" id="cthr:CTHT_0007090"/>
    <dbReference type="eggNOG" id="ENOG502S1H2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063084_0_0_1"/>
    <dbReference type="OMA" id="VSDCAQM"/>
    <dbReference type="OrthoDB" id="4590657at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF1">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408641" description="CFEM domain-containing protein" evidence="17">
        <location>
            <begin position="21"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="18">
        <location>
            <begin position="2"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGS23998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="228" mass="23442" checksum="60AF5D26138F033B" modified="2011-10-19" version="1">MMKSGLITLLTLAGAATVAATDFPPNMPECAKWCATEMLENKPGELGCNVGDVTCLCQNQNFAYGVRDCSHGKCGYNADSDFAIAWVNSFCGGILATATTSASYIESPSIEPTPIWTTTYTTTFTTDGIVSTTTGTSTVFGISGVPVYTSHPFTTVTSTFVSTHTSGSSTFEVTHATTFTTSVDSASLTEPTEAEHPSSSSSEGHGAQITGAPALGVLAAAGLAAVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYT5</accession>
    <name>G0RYT5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="2">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0007830</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="2"/>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS24071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691313.1">
        <property type="nucleotide sequence ID" value="XM_006691250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYT5"/>
    <dbReference type="STRING" id="759272.G0RYT5"/>
    <dbReference type="GeneID" id="18254821"/>
    <dbReference type="KEGG" id="cthr:CTHT_0007830"/>
    <dbReference type="eggNOG" id="KOG0169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002738_3_1_1"/>
    <dbReference type="OMA" id="KVHICES"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF169">
        <property type="entry name" value="PHOSPHOINOSITIDE PHOSPHOLIPASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="4">
        <location>
            <begin position="160"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="105"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS24071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="384" mass="42185" checksum="06CBFDEE8B9C032C" modified="2011-10-19" version="1">MEPKVTHGYTLVSNVPFRAVCEVIRDVVDQEATVAAAGGMFPAPILVSLENHCDSAGQRRLVEIMHEVWEDRLLSTPIRPNDDTHVTLEELGGKIAVMVEYHLPEEKDSSSSSSSSSSSSSDSSDDEQKKAKAEYKAKKRRHPRSSYQSLHSLPKDGPPFHLINVSETGLSSHMADHAAKISRHNARHLLRVYPKGMRISSRNLSPIPFWGVGAQICALNWQTFGASMQLNDALFAGTPGYVLKPAALRRDGSGVLSQDAPRRILRLTVAGASNVPLPSGRSSNDLRPYVTCSLLQPRDDGGLAKVKRKTAVYRRHSLPFLSDDGPGPTDPVWNETLEWEFDDNELVFVRMLIKSDDSWSANPVLAVAANETKSAASITWNAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZU8</accession>
    <name>G0RZU8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0004270</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690968.1">
        <property type="nucleotide sequence ID" value="XM_006690905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZU8"/>
    <dbReference type="STRING" id="759272.G0RZU8"/>
    <dbReference type="GeneID" id="18254465"/>
    <dbReference type="KEGG" id="cthr:CTHT_0004270"/>
    <dbReference type="eggNOG" id="ENOG502RVVQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_316682_0_0_1"/>
    <dbReference type="OMA" id="NIDQRPG"/>
    <dbReference type="OrthoDB" id="5234071at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="369"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="764"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="931" mass="99351" checksum="BFA355DD76D5E20F" modified="2011-10-19" version="1">MDGRKSDRNIQEKQPQSQQQKWKRIDQNALGEGQFFGKNVHHTVVVNGSIRSVSRAGTPNSARSPYFHDTHNLAAASMFDLNNLGPGRRGSQSSLNLKAAASDINLRGRFRANNMSSISLTAPNPAFAAPSSSRPGTANGRSKPWVNPLDVHFCRNTPSGPATPKSPLATSPLQLPPTPTTDDAESKSVFGEDADKMVEQVMASVNKMEEEAKKARERERELEKQRETARLEMQRLERQKSTESTLSMRRPSVAQTDPEPDPEPLPALPALPDPEPAAAPKANPNSRPSSRGGPTAQIRSPLIHQGPPPTDPPTQSLPQLPAAALSRQGSNATVRPGTSGSAASSSASQEASSPTIVARPFGAAYQGITPSSPTSGSPNTQGAPKKIYRPYRPSPLTGPSLLNPGLGATSPPPKSPLLGKDYVESPVLGGYPPSAARANDEVKTPDAPKTPVQETKGLEPLLASLTSPSNMTSPATSIRRLSLDEEPIDQSLRPIIREVTAKRETVLTPRQHSLSMKIEELEKSLLTAQRQAHMSTTEESKRDSMTSSFYDEMDKFDDDDDGPILPAPLRIHPAERELTATPSSPRTAALVTAPVASPPTIPATGPVSSPPTIPAAAPAKRPESPFRIPVRRGPPPRRPTLDEYGVSPSQVSRRAGTATPTSRSGSFDDHSRGPSLDNGSRGGSIDNYSRSNSLDNYSVQNSPASRAQTPQLRHPNWRRDPPPAPSPIVEEAPPHPPNPNGFVDTGFNFDFGPSVACPAPPTPDSANWPLQSSVPEKPAASPPRAITESPEAIQSNHTRGRLARANVPPPLNLQFNNFNFSPDAPSRDPTLFSQKSLLTPPLRTAPPPTTGSMEVDSRPDTSSRANGVGNGSAGLAASPRLVSQFPPDDDRAAAFMGIGVARGPSIRQVRRPPQSQGGRLEMVDEFGTGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZZ8</accession>
    <name>G0RZZ8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha-ketoglutarate-dependent dioxygenase AlkB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0008200</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <dbReference type="DOI" id="10.1038/nsmb.3476"/>
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            <title>Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration.</title>
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                <person name="Cheng J."/>
                <person name="Bassler J."/>
                <person name="Fischer P."/>
                <person name="Lau B."/>
                <person name="Kellner N."/>
                <person name="Kunze R."/>
                <person name="Griesel S."/>
                <person name="Kallas M."/>
                <person name="Berninghausen O."/>
                <person name="Strauss D."/>
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        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="476" last="476">
            <title>High-resolution structures of a thermophilic eukaryotic 80S ribosome reveal atomistic details of translocation.</title>
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                <person name="Wild K."/>
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                <person name="Gese G.V."/>
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        <property type="entry name" value="S4_RNA-bd_sf"/>
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        <property type="entry name" value="uS4_arch"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF5">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="13 14 15" id="KW-0002">3D-structure</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="10">
        <location>
            <begin position="4"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="9">
        <location>
            <begin position="105"/>
            <end position="178"/>
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    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
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    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="9">
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            <dbReference type="SMART" id="SM00363"/>
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    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01390"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS22704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
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    </evidence>
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        <source>
            <dbReference type="PDB" id="5OQL"/>
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    </evidence>
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        <source>
            <dbReference type="PDB" id="6RXT"/>
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            <dbReference type="PDB" id="6RXU"/>
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            <dbReference type="PDB" id="6RXV"/>
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            <dbReference type="PDB" id="7OLD"/>
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            <dbReference type="PDB" id="7Z3N"/>
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        <source>
            <dbReference type="PDB" id="7Z3O"/>
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    </evidence>
    <evidence type="ECO:0007829" key="21">
        <source>
            <dbReference type="PDB" id="8OO0"/>
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    </evidence>
    <sequence length="190" mass="21983" checksum="57108617D2C152E3" modified="2011-10-19" version="1">MAPRKYSKTYKVPRRPYEAARLDSELKLVGEYGLRNKREVWRVLLTLSKIRRAARILLTLDEKDPKRLFEGNALIRRLVRIGVLDESRMKLDYVLALKAEDFLERRLQTLVYKLGLAKSIHHARVLIRQRHIRVGKQIVNVPSFMVRLDSQKHIDFALTSPFGGGRPGRVRRKKAKAAEGGEGGEEEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0S101</accession>
    <name>G0S101_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal protein L37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0011850</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="476" last="476">
            <title>High-resolution structures of a thermophilic eukaryotic 80S ribosome reveal atomistic details of translocation.</title>
            <authorList>
                <person name="Kisonaite M."/>
                <person name="Wild K."/>
                <person name="Lapouge K."/>
                <person name="Ruppert T."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="35079002"/>
            <dbReference type="DOI" id="10.1038/s41467-022-27967-9"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.90 ANGSTROMS) IN COMPLEX WITH ZN(2+)</scope>
    </reference>
    <reference evidence="17 18 19" key="3">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e56910" last="e56910">
            <title>Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation during pre-60S biogenesis.</title>
            <authorList>
                <person name="Lau B."/>
                <person name="Huang Z."/>
                <person name="Kellner N."/>
                <person name="Niu S."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
                <person name="Cheng J."/>
            </authorList>
            <dbReference type="PubMed" id="37129998"/>
            <dbReference type="DOI" id="10.15252/embr.202356910"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS) IN COMPLEX WITH ZN(2+)</scope>
    </reference>
    <reference evidence="21 22 23" key="4">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e57984" last="e57984">
            <title>Structural insights into coordinating 5S RNP rotation with ITS2 pre-RNA processing during ribosome formation.</title>
            <authorList>
                <person name="Thoms M."/>
                <person name="Lau B."/>
                <person name="Cheng J."/>
                <person name="Fromm L."/>
                <person name="Denk T."/>
                <person name="Kellner N."/>
                <person name="Flemming D."/>
                <person name="Fischer P."/>
                <person name="Falquet L."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="37921038"/>
            <dbReference type="DOI" id="10.15252/embr.202357984"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.12 ANGSTROMS) IN COMPLEX WITH ZN(2+)</scope>
    </reference>
    <reference evidence="15 16" key="5">
        <citation type="journal article" date="2023" name="Nat. Struct. Mol. Biol." volume="30" first="670" last="677">
            <title>Structural inventory of cotranslational protein folding by the eukaryotic RAC complex.</title>
            <authorList>
                <person name="Kisonaite M."/>
                <person name="Wild K."/>
                <person name="Lapouge K."/>
                <person name="Gese G.V."/>
                <person name="Kellner N."/>
                <person name="Hurt E."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="37081320"/>
            <dbReference type="DOI" id="10.1038/s41594-023-00973-1"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.20 ANGSTROMS) IN COMPLEX WITH ZN(2+)</scope>
    </reference>
    <reference evidence="20" key="6">
        <citation type="journal article" date="2024" name="Nat. Commun." volume="15" first="716" last="716">
            <title>Methionine aminopeptidase 2 and its autoproteolysis product have different binding sites on the ribosome.</title>
            <authorList>
                <person name="Klein M.A."/>
                <person name="Wild K."/>
                <person name="Kisonaite M."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="38267453"/>
            <dbReference type="DOI" id="10.1038/s41467-024-44862-7"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.10 ANGSTROMS) IN COMPLEX WITH ZN(2+)</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic ribosomal protein eL37 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_006691640.1"/>
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    <dbReference type="PDB" id="7OLC">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="Lj=1-95"/>
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        <property type="resolution" value="3.30 A"/>
        <property type="chains" value="Lj=1-95"/>
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        <property type="resolution" value="3.60 A"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    <dbReference type="HAMAP" id="MF_00547">
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    <dbReference type="InterPro" id="IPR001569">
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    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018267">
        <property type="entry name" value="Ribosomal_eL37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
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        <property type="entry name" value="PRK04179.1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768:SF0">
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    </dbReference>
    <dbReference type="Pfam" id="PF01907">
        <property type="entry name" value="Ribosomal_L37e"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01077">
        <property type="entry name" value="RIBOSOMAL_L37E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="13 14 15" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2 9 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9 11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 9 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13 14 15">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14 15">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14 15">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14 15">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS22711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="7OLC"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="7OLD"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="7Z3N"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="7Z3O"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PDB" id="8I9P"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PDB" id="8I9R"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="19">
        <source>
            <dbReference type="PDB" id="8I9T"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PDB" id="8OO0"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="21">
        <source>
            <dbReference type="PDB" id="8PV1"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="22">
        <source>
            <dbReference type="PDB" id="8PV2"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="23">
        <source>
            <dbReference type="PDB" id="8PV3"/>
        </source>
    </evidence>
    <sequence length="95" mass="10631" checksum="BE1C510C90B07ACB" modified="2011-10-19" version="1">MTKGTSSFGKRHNKTHGLCRRCGRRSLHNQKKVCASCGYPAAKTRKYNWSEKAKRRKVTGTGRMRYLSTVPRRFKNGFRTGVPKGARGPAVSTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G0S183</accession>
    <name>G0S183_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Roadblock/LAMTOR2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0012680</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GAMAD family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691785.1">
        <property type="nucleotide sequence ID" value="XM_006691722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S183"/>
    <dbReference type="STRING" id="759272.G0S183"/>
    <dbReference type="GeneID" id="18255306"/>
    <dbReference type="KEGG" id="cthr:CTHT_0012680"/>
    <dbReference type="eggNOG" id="ENOG502S7RW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113002_0_0_1"/>
    <dbReference type="OMA" id="DFAAMIW"/>
    <dbReference type="OrthoDB" id="9985637at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10779">
        <property type="entry name" value="DYNEIN LIGHT CHAIN ROADBLOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Roadblock/LAMTOR2" evidence="3">
        <location>
            <begin position="16"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS22793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="147" mass="15441" checksum="DD4EE409E91D55BC" modified="2011-10-19" version="1">MATVSDPVLATGPDALEESLGRLSKKPGVKAAIVLDRASGTILKTTGQVGTIRKPKPTGSSTESPSPAPAAGAFSGEGDASNSNQNQDVEEVAALVWNFVNTAGGLVEELDAEDEMRLLRLRTKRQEFVIVPDPKYLLIVVHDTSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1I8</accession>
    <name>G0S1I8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LicD/FKTN/FKRP nucleotidyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0013750</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691890.1">
        <property type="nucleotide sequence ID" value="XM_006691827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1I8"/>
    <dbReference type="STRING" id="759272.G0S1I8"/>
    <dbReference type="GeneID" id="18255413"/>
    <dbReference type="KEGG" id="cthr:CTHT_0013750"/>
    <dbReference type="eggNOG" id="ENOG502QREF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_529957_0_0_1"/>
    <dbReference type="OrthoDB" id="444255at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009644">
        <property type="entry name" value="FKTN/MNN4/W02B3.4-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD/FKTN/FKRP_NTP_transf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407">
        <property type="entry name" value="FUKUTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407:SF28">
        <property type="entry name" value="RIBITOL-5-PHOSPHATE TRANSFERASE FKTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408754" description="LicD/FKTN/FKRP nucleotidyltransferase domain-containing protein" evidence="6">
        <location>
            <begin position="33"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="7">
        <location>
            <begin position="258"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="78"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="461"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="462"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="487"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS22898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="514" mass="57338" checksum="BAA6F979643DB206" modified="2011-10-19" version="1">MIPPILRRPHPAFIVLTALIALSFLLSSAAVARNDDRTAFSASFAPAAQEVQNSEPVAVGVEEVVKAVLPTVTTTLPTTTAMTAPKETTTQVKGESTTKKEEDIKEAKTMVTVTVSTRATTSSSNPSVSTQPANRPPQPSPHNDNNNNNPKQANSISFTKQHRPPAAAIPPPPLPSTSTSSLRLAPSHNPPPSRPLPNSRPNMRLGLHVPEEYKYFHEAGKSMALTHYDARFFRDALPYEEHRIALRNLIRSYLATTSKLGIETWLAHGTLLGWWWNGRIMPWDYDVDVQVSGATMGEMVRRGLNGSFWSYPDESEGTTVDKRTYLLDINPHWSQLERGKGLNVIDARWIDTQTGMFVDITVLMEREPKKMPGVWSCKNRHYYDPWKQLYPLRETVFEGVRALVPFAVEEVLVAEYGEKCLVATEWEGHRWDGELREWVKMKVIPSSTQTPPGAVETLAAEASKKPETLETPRVVPAEETRIKKPNNESNVEQTLSEDPAVPLDGLRPDKAFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1J0</accession>
    <name>G0S1J0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ER lumen protein-retaining receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0013770</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ERD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691892.1">
        <property type="nucleotide sequence ID" value="XM_006691829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1J0"/>
    <dbReference type="STRING" id="759272.G0S1J0"/>
    <dbReference type="GeneID" id="18255415"/>
    <dbReference type="KEGG" id="cthr:CTHT_0013770"/>
    <dbReference type="eggNOG" id="KOG3106">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057784_0_0_1"/>
    <dbReference type="OMA" id="WKSRSCE"/>
    <dbReference type="OrthoDB" id="7694678at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00951">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00952">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS22900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="209" mass="24574" checksum="6AEF06CED272DC07" modified="2011-10-19" version="1">MTLNIFRVLASIFILLHKIVQLKSCSGISFKSQMLYLLVYITRYLDLPWTRSSYNFIFKVLFISSQCYIIYLMARAYKPTNDPNLDTFRVEFLLGFAFILAILFPVQYTFLEIAWAFSIWLESVAILPQLFMLQRTGEAEAITAHYLFALGTYRALYIPNWIYRYYTEGPRKVDTIAVVAGVLQTLLYSDFFWIYYTKVVRGEKFKLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0S203</accession>
    <name>G0S203_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative lipoate-protein ligase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0015490</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LplA family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS23063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692055.1">
        <property type="nucleotide sequence ID" value="XM_006691992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S203"/>
    <dbReference type="STRING" id="759272.G0S203"/>
    <dbReference type="GeneID" id="18255587"/>
    <dbReference type="KEGG" id="cthr:CTHT_0015490"/>
    <dbReference type="eggNOG" id="KOG3159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022986_3_0_1"/>
    <dbReference type="OMA" id="TTFTRNK"/>
    <dbReference type="OrthoDB" id="201621at2759"/>
    <dbReference type="UniPathway" id="UPA00537">
        <property type="reaction ID" value="UER00595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017118">
        <property type="term" value="F:lipoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16443">
        <property type="entry name" value="LplA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004562">
        <property type="entry name" value="LipoylTrfase_LipoateP_Ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561">
        <property type="entry name" value="LIPOATE-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561:SF3">
        <property type="entry name" value="LIPOYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="5">
        <location>
            <begin position="65"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS23063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="448" mass="49949" checksum="8F0701E41B100D5B" modified="2011-10-19" version="1">MFHNVDPPSCGSHALGINHKLRFSPKLVTRYFTQNLIRPFQIYRSASSDPYVNLSIEHHLLQSSPPDSTILFLYTNRPSIVIGRNQNPWLEVNLRLLRDGLPTSESQDKKQPIALVRRRSGGGTVFHDKGNTNYSVICPPAVFDRDRHAEMVARALRKLGVPHRTCGSRPGGGVRVNERHDIVVDILSPSGGMFKISGSAYKLTRTRALHHGTCLLSSPNLGSVSALLRSPAEGFIKARGVESVRSPIRNVNVGTEEFVDAVVDEFCDMYGVEDGGKEVLVIREEEALATEGINKGVRELTDPEWIFGQTPLFTFSTHPTEDDPRDRPPSLLAQLPHDFQGRITVRHGEIQSVYLSLSDDPFNMTDPSPLSQVLAKERLHHISDWRAVLSKAVSEAPLSDAFDVEQVGMWLNRMFGIPEPVEGQKERSLSEEVVRAIQESKLGMWLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2B8</accession>
    <name>G0S2B8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">glutaryl-CoA dehydrogenase (ETF)</fullName>
            <ecNumber evidence="11">1.3.8.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CTHT_0016680</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>glutaryl-CoA + oxidized [electron-transfer flavoprotein] + 2 H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13389"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid metabolism; lysine degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amino-acid metabolism; tryptophan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.6" evidence="11"/>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692170.1">
        <property type="nucleotide sequence ID" value="XM_006692107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2B8"/>
    <dbReference type="STRING" id="759272.G0S2B8"/>
    <dbReference type="GeneID" id="18255706"/>
    <dbReference type="KEGG" id="cthr:CTHT_0016680"/>
    <dbReference type="eggNOG" id="KOG0138">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_8_0_1"/>
    <dbReference type="OMA" id="HMMNLES"/>
    <dbReference type="OrthoDB" id="435240at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004361">
        <property type="term" value="F:glutaryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046949">
        <property type="term" value="P:fatty-acyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01151">
        <property type="entry name" value="GCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000003">
        <property type="entry name" value="glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000006">
        <property type="entry name" value="Glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000008">
        <property type="entry name" value="Glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052033">
        <property type="entry name" value="Glutaryl-CoA_DH_mitochondrial"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807:SF1">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="16">
        <location>
            <begin position="48"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="15">
        <location>
            <begin position="163"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="14">
        <location>
            <begin position="278"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGS22151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="428" mass="47031" checksum="5ED50DD5D824FDB7" modified="2011-10-19" version="1">MSRLLCRHFPRRALLARPAYSARSYASSASAAPQFNWEDPLNAKNLLTEEELAISEMAERYCQEHLAPRVLQAYRDEHYDPKILQEMGELGLLGATIKGYGCAGVSTVASALITRAVERVDSGYRSGMSVQSSLVMGAIHDFGTEELKEKYLPQLAKGKIIGAFGLTEPNHGSDPGSMETTAREHPTKQGYYLLKGSKTWITNSPIADVLVVWARLQETGKIRGFLVDRSMCPPGALETPAIKNKTGLRASITGMIHLEDCPVPKEHMFPDVEGLKGPFTCLNSARYGIALGVMGALEDCIARARTYALERRQFKGNPLAKYQLVQKKLADATTDAAYGVLAAIQVGRLKDEGKATPEMISMIKRQNCDRALWNARVLQEIFGGNAVSDEYHIGRHVANLYVTQTYEGQSDIHTLILGRAITGIQAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2D5</accession>
    <name>G0S2D5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lethal giant larvae (Lgl)-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0016850</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat L(2)GL family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692187.1">
        <property type="nucleotide sequence ID" value="XM_006692124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2D5"/>
    <dbReference type="STRING" id="759272.G0S2D5"/>
    <dbReference type="GeneID" id="18255723"/>
    <dbReference type="KEGG" id="cthr:CTHT_0016850"/>
    <dbReference type="eggNOG" id="KOG1983">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006030_0_0_1"/>
    <dbReference type="OMA" id="QIYVFGQ"/>
    <dbReference type="OrthoDB" id="19944at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045159">
        <property type="term" value="F:myosin II binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013905">
        <property type="entry name" value="Lgl_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241">
        <property type="entry name" value="LETHAL 2 GIANT LARVAE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241:SF25">
        <property type="entry name" value="TOMOSYN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08596">
        <property type="entry name" value="Lgl_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="257"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Lethal giant larvae (Lgl)-like C-terminal" evidence="7">
        <location>
            <begin position="556"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="983"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="983"/>
            <end position="997"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS22168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1065" mass="114056" checksum="5C4EA5AA83ED914D" modified="2011-10-19" version="1">MSFIRHRNTPDLSAGLVPPGSSSQTGWTSPFAEQTSRLLSRHGINSLVTCLAYDPVQSLLAVGTAESKYGRGRIYLFGAGRVQRVIDPPPPNETSSGIAGLGLTKKEGAASVVDVRFVCGGRRLLVLDGGDHVLLYDLAACPPGLVGRATYAKVACLATDPALEWALVGLQAGGDVMAFDLVSGRPAVGGGAWRLGNVWREREREKGRVAGLHSIGVVGVHWHPRDVGKLAVAYTEAVVVYSFKRNEVQKWLELPQHQTGKARITCAAWHPTGTFIVAGLDDGRLVVWDVKEGRVLCVCTVVVDSIEDNSCRRAPIAKLSWCCKSPSNPDDTALLILGGNAPSLSSPSTSTTSTTPLTFLDLGPTPTYATSSWDTLTQHFTAPKRLVPLPVPPGAEVASYTLIPRSSPHYHGACDPIAALVLLTSGEVVTLTIPSGYPISPTNMLPPSLSFIHPFVNRIFLTHIPRERWLGLVEKRQTGENFLRGGAPAPTFHGESRYPYPFRHVVLAAHADCTIRAWDVGFGRSSEIENAGQLQVDVARAVGRVGETDASGMAGVTVVGMSEVTAEMVAGTKGGEVVVWRWGVNNNNAFLGRREDEKEEGETKPGEVRDISHRTEPNLREGLMPLVLYALPGGKAPVSAVKVSDVGFVAAASENGCVSVLDLRGPAVIFQAQVGDLTREQDKRSSLLAFGKGKHAMDGRPEFATVLEFGVMTLGEDGYSSIACFVGTDRGRVVTLKILPVQGAGKGQPGYRVEPAGVSKVGSDRVMAVCPVNGDNGLPAAATVDAVAGLREGRKVDGILVVATQSTARVFKPPTSKPVASRSLDDISGHLCDAASVVYPPRSLSSPNVPPFAALLTLHSSGSLARIFSLPHLKELSHLSLPALDPARALNAAISRSGSILAWMGPSEIGLYSVWRETQQGYQRRDERYHGAGDGGDFLVIEGRECPARPTISGVEWVTGTQYVSVTDLGILIGGEGWERRREMEKQAAQGAHREEGGGTASKSQEGWGEYLARQIDERMERLNVVDDAMMKLQETTQGWSESVNNYVKKQKREALLGSIKKSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2S6</accession>
    <name>G0S2S6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0018320</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692328.1">
        <property type="nucleotide sequence ID" value="XM_006692265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2S6"/>
    <dbReference type="GeneID" id="18255870"/>
    <dbReference type="KEGG" id="cthr:CTHT_0018320"/>
    <dbReference type="eggNOG" id="ENOG502S4NI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090057_2_0_1"/>
    <dbReference type="OMA" id="RCDKMCA"/>
    <dbReference type="OrthoDB" id="3511549at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="66"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="162" mass="17990" checksum="5FA615B5F1F3AC93" modified="2011-10-19" version="1">MLTSTLLPVLEDLLPLFLPSSVSVTRAHDVLPPFEYHIDRSDPRVQVFSRDAVVKQSDKICTSILILKPTTSSTIRHHGEQDTIIYVVSGFGLLLSQPKSGEDLDRRQIGPGDFAYIPAWMEHQFQNTSDQADLHLVIIRSGGAPVEVSLTDWGGSRLDPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2W0</accession>
    <name>G0S2W0_CHATD</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0018670</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22343.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006692299.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="18255905"/>
    <dbReference type="KEGG" id="cthr:CTHT_0018670"/>
    <dbReference type="eggNOG" id="ENOG502RJEQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1876295_0_0_1"/>
    <dbReference type="OMA" id="VRIHIQE"/>
    <dbReference type="OrthoDB" id="4567962at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="136" mass="15356" checksum="034CC5302703A04A" modified="2011-10-19" version="1">MGSAISRCASRGSSRLASDYDDEKILGRQPNWLVPPALWRSRSKTSSGQPVRYRTPTPYPKGDRKPLPHEPQHVRIHIQEKTASTIVTPVVNHLEVASAGKHSRKPQQTSRSIRQPSNITITWESPVTGRLNRFER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>G0S395</accession>
    <name>G0S395_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0020190</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692497.1">
        <property type="nucleotide sequence ID" value="XM_006692434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S395"/>
    <dbReference type="GeneID" id="18256057"/>
    <dbReference type="KEGG" id="cthr:CTHT_0020190"/>
    <dbReference type="HOGENOM" id="CLU_601290_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="455" mass="49721" checksum="D15232196F182FF8" modified="2011-10-19" version="1">MQFVRMPGDLRNLVRHYARQDSYLWDTIDRGSAWTPWSHHIPSAQLRVQFFQAVLKVIDDLIPRVTFCLADWQATTRPIPAFPNFKARSDSQSNSCSSSPHQPVPSHSLVPAPSPALSPAAPTTLWPTSSVQAHNPLFSRLQWAVQRASPRLEEYRSMVSRSSTTGITNHSSESQQGQRVQTQRQVVQPQQTLTPARSSTGSFTMEPDWHDARSEGSTTDVSDVDSMTRCVILGYARYHPGEGNPQDLTVNDSNKDVGSDANFARPRDSLKLSDYNTLKSDNASVDATQVALAPVTEQTQTSQKTNEQEQFPLNPTLTESSPGPGADSEESMGNGNEANKQDSLRRQFTPCHQSSPVTTPATSVSLLSSKIDLAVEENTSALSLSPATTDDIQPTANQEDNTNGEIPDDHCATNKVNLEDLKDAANTPIVPTIIPTLPSEFPVILPGPPFSGTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3A9</accession>
    <name>G0S3A9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0020360</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692511.1">
        <property type="nucleotide sequence ID" value="XM_006692448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3A9"/>
    <dbReference type="GeneID" id="18256074"/>
    <dbReference type="KEGG" id="cthr:CTHT_0020360"/>
    <dbReference type="HOGENOM" id="CLU_315207_0_0_1"/>
    <dbReference type="OrthoDB" id="5244599at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="703"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="744"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="787"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="650"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="709"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="806"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="927" mass="100265" checksum="9671159D45533FA8" modified="2011-10-19" version="1">MAPDPSPSSYFNPAFSSHNDREAAETSPLLEVLHQYQYATHRPSKIPIRKGSNPHHKHNDSGVALSPPEPLPCRRPSKVLRGGIYNTVIGYGSATDEIMRLQHGRSASITAHISGRIADFPRGSGVYNTVTGRGSLNDTSRNRQYASNAVKNVQAETISRAADVTHLTDFSEEKQKGISLDEPEFAPRFPFDTGAPDDSFLFEDPSVDSSRDLFPILASFPAVPRPLGERSPGSVEALSKGTVPSSSIPTDAEVQDNPAPKSVVVSKETFKNFNLEEHPGPPSRDDTTRRSVDISPKTYARQWTTDPKGFGESSLVNPPQPPSEPVTPAELRMAQESEVPRADKKQKLFGLFYFGKDQPKDSMPGFERKRRTSSITSKTRNKLRKRSIKDSRAERNNLRAQTAPTADPRRSFSEAVVAVGAGVLGLLHHERKENSVHEGELTALQQALHGWSHASPASPTLERSADHAMTPTLTRHLGGQVTHPGGSGSAVLAPVEWTGTSTPFEHPREPPIPPLPPQFSYKQPSQPPPRIHHTAPGPSSSTIPNEPPQLPHPVTVQTHLHDIRDQFDLPTTTTTPSISPKTLPVLSTSHGIDETASIDSLIADLDNTLHPHDHPSSCQPQSQQATGTVTCLTPSPAPEIPPKSPSRLSQQRAHQPHQPQQQQQHLAAPAPLRPAVQTYETFGCSPNLGDRQHFSRASDIPSIATDAHLSSRHEPARGEEGMSEPEVEDTIAEDVLDILSNPRESAVSPLGSRSVSEHEGHYPEGGGEEEGEHLAEVRRRTGTSPTVPAIILRPPAGVGSAGEGGSAAASVGSVGTDQGSKMSKAEKRCTVSALVPPLELGPGPAKTMPALLPFEGMEKEISYVTRASSIPTVHSGRMPVAEEAPLPMPRGEVSMKVMHRCVFCGRENDISAYFRGLEIKVEKQNED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3D1</accession>
    <name>G0S3D1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0020580</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692533.1">
        <property type="nucleotide sequence ID" value="XM_006692470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3D1"/>
    <dbReference type="STRING" id="759272.G0S3D1"/>
    <dbReference type="GeneID" id="18256096"/>
    <dbReference type="KEGG" id="cthr:CTHT_0020580"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_34_10_1"/>
    <dbReference type="OMA" id="DECQMSG"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="10"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="188" mass="21363" checksum="16F7C869A996BC21" modified="2011-10-19" version="1">MDAYSRHQKHRSLPSLGNLEEMFHAVATLYKDPVFIIIDALDECQMSGNVRSKFIETLLSLQSRGIDINILATSRPVPDIVEAFDGHSCLEIAAQRDDIERYLRNKMSELPVVSKYPDLQHEIISCIASVADGIFLLARFFFESLKDKVSAKLIRKTLNELQNNSKEKKSKYALLCRAYNDAVERING</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3G6</accession>
    <name>G0S3G6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">P-type Na(+) transporter</fullName>
            <ecNumber evidence="19">7.2.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">CTHT_0020970</name>
    </gene>
    <organism evidence="26">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>K(+)(in) + ATP + H2O = K(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75815"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>Na(+)(in) + ATP + H2O = Na(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:14634"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.3" evidence="19"/>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692568.1">
        <property type="nucleotide sequence ID" value="XM_006692505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3G6"/>
    <dbReference type="STRING" id="759272.G0S3G6"/>
    <dbReference type="GeneID" id="18256135"/>
    <dbReference type="KEGG" id="cthr:CTHT_0020970"/>
    <dbReference type="eggNOG" id="KOG0202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_3_0_1"/>
    <dbReference type="OMA" id="FGIDDYI"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008554">
        <property type="term" value="F:P-type sodium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000016">
        <property type="entry name" value="Calcium-transporting P-type ATPase putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000193">
        <property type="entry name" value="Plasma membrane calcium-transporting ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000015">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006414">
        <property type="entry name" value="P-type_ATPase_IID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01523">
        <property type="entry name" value="ATPase-IID_K-Na"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="17" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="219"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="435"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="881"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="918"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="964"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1005"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1059"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1091"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="24">
        <location>
            <begin position="95"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00035017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00035029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="EGS22549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1133" mass="121047" checksum="260994D0ECDAA6F7" modified="2011-10-19" version="1">MGTENDLDVEAQTEPPICGPKSKSSIAFTISPSPTPAGTFVNATVGPDADAEPGAAAATDTDADATPITVGTGRASLASTVDTVAATAPSFFPEIAHTLSVPDVCALLDTDADAGLGVIEAPPPYDLLDPLSDLDLASVTSLRITDAQHHHQCIADQYRNGLNPAEAGRRLQWHGLNKVEGAKGLSPLTILIRQVSNSLTLVLVMTMILSFAISDHIEGGVIAAVILLNIVVGFFQDYRAEQTIQALYALSAPTCKVIRDGKAETIKAETLVPGDLVRLNVGDIVPADLRLVHSINLSTDDALLTGESVPVSKHAEIILKDRDVPLGDRANMVYSASTVTRGRATGIVVATGMMTEVGKIAAMLKRSSGKTADVDSGRVQEAWIRFRNGLRVLLGLDGTPMQVSLSKFALLLFALAITLAIIVFSVSRWKVTSEVLIYGICVAVAVIPESLIAVLTIATALGTRAMAKGNVIIRKLASLEAVGGVTNICSDKTGTLTQGKMVAKQLWLADGTEMSIRNTTHPFDPTSGSVHVGDEIYNWGIFDKTKASLLTAFLKTVALCNNSLVTKTESAYTAVGEPTEIALQVLAMRLGMGKPTLLEPGNRQLLAEYPFDSSCKMMTVVYTDEQGAYAYTKGALEAILPLLDASDELKAQAVTRAEALAAEGLRVLCVAQKMVDPRDFGLVSDNADTEKVSPIIKTATPERSAVERGLTFLGLAGLYDPPRPETAGAIRKCKDAGIQVHMLTGDHVKTATAIAYEIGILKKGALIGPNDVMLATAFDNLTDAEIDAMDHLPLVLARCSPTTKVRMVEALHRRKAFCVMTGDGVNDSPALKKSDVGIAMGLNGSDVAKEAADMVLTDDNFASIVRAIEEGRRLFDNIQKFLLHLLVSNIAQVFLLLIGLAFKDPHGISVFPLSPLEILWANLVTSSFLALGLGLEEAQPDIMQRPPHDLSIGVFNRELIVDKFVYGTAMGGLCLAAFTSVAYGVSRNEGLGLGCNEDFALGCLVAFRARATTFATLTFLLLVTAWEAKHFTRSLFNMHPERYSGGVLSLCRTVWQNKFLFGAVTAGVVIVFPVIYLPVVNRAVFKHDAITWEWGIVSACVAVYMAIVEVWKALKRRFGLGTTVLKGRLESEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3I8</accession>
    <name>G0S3I8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0021410</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692611.1">
        <property type="nucleotide sequence ID" value="XM_006692548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3I8"/>
    <dbReference type="STRING" id="759272.G0S3I8"/>
    <dbReference type="GeneID" id="18256179"/>
    <dbReference type="KEGG" id="cthr:CTHT_0021410"/>
    <dbReference type="eggNOG" id="ENOG502SJYP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029272_1_0_1"/>
    <dbReference type="OMA" id="ERGPFYE"/>
    <dbReference type="OrthoDB" id="4074350at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409276" description="Peptidase A1 domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="3">
        <location>
            <begin position="42"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS20315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="529" mass="57171" checksum="731ECB1FB30D3C3F" modified="2011-10-19" version="1">MSPSLLFFFLSGLAYASESEATPKQFKFTENTHIFGADGPWHGVEVSIGDQPTLMIPGRSWESYVITTDYCKATSGSATCEVGAYDPSRYGKTVPELDHVTFFTQNATRGIKTTGTSRMVFDSVTLDGVGTVPDHTLALIENESQMLEYPNGKRYPIMTGCLSLGSLASKSIFWTPDQKLMDVDVGNMIAYYLAGNDVIPSASYGFHYGSALPSSKIPGSLIFGGYDRNRVIGRVDSQGSYIDGSFVLRRLAVNTFEGSAPFEMTGVQIIPGTYKYSTDTGISVRLDACSPYLTLPSDVCKGIASYLPIYHHEGLDLWLWNTSHPGYKLIVESASALTFDFDAGERGKSTTIHLPLMQLNLTLGPPFTGEIPGMEGKEVPYFPCHSSPGHSGAWVLGRPIFQSLFIGANFLTKQLWLAQAPGPKIPSESDIVKIGRYDYDIESSKMKWTDTWNAVWRGLSQDEALIARGLYEPERRPSSSAGTGNGGSGGGGGSQTGSSDSNRSSASTIVGSRFGKFVMLASMLAVVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3L4</accession>
    <name>G0S3L4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nuclear distribution protein nudE-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0021680</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nudE family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692637.1">
        <property type="nucleotide sequence ID" value="XM_006692574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3L4"/>
    <dbReference type="STRING" id="759272.G0S3L4"/>
    <dbReference type="GeneID" id="18256206"/>
    <dbReference type="KEGG" id="cthr:CTHT_0021680"/>
    <dbReference type="eggNOG" id="KOG1853">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034391_0_0_1"/>
    <dbReference type="OMA" id="NMAIERS"/>
    <dbReference type="OrthoDB" id="5877028at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051642">
        <property type="term" value="P:centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033494">
        <property type="entry name" value="NUDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006964">
        <property type="entry name" value="NUDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921:SF1">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04880">
        <property type="entry name" value="NUDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NUDE" evidence="9">
        <location>
            <begin position="131"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="194"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="399"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="19"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="311"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="328"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="443"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="464"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="504"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="529"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="563"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="580"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="602"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS20341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="668" mass="73101" checksum="ECA7109DE773CF29" modified="2011-10-19" version="1">MIEPPTSPPNSSTKPEEALAWYKAQYEMLEQELSEFQASSKELEAELEKDLEAADKRERALREKIEGLSFEVEEWKRKYKESKAEASAAQSNLEKEITSLRDANRTLQLKLRDIEVANDDMERHARHTTSSLEDLESKYNIAIERGVMLEEEIKLGEQERERLRVEAQRLREELSDLKIEAEILQDKIRKQNSHMSNLSTDLTIPGSPSYLHSPRSNTSSPMNITTPPDTKSLSTIDTISEPQDPPSPPMSDVSMPLPKLSSLKTPNRLPRSRLPSADCSITPKPRPVNASSSSSRGGARSVTTSISSETRTTETRPPEPRRPRPSGPRESAALRAARAARGVSSTNSLTHIRTLTAQMQKLEARVHSARSKLPNSANTKDTPFASAFTNAYGPDNTYTGNHNFSSSNHTYSSSTSTPPRPSTRSASGNVSGTLSIRTRKRTVGSNASTSSQTSDEQLPPPSLAQSRHPPSASRSSIASASKHVPRLSSSSGVSRFSHGPLPNRNPTANGSTINHHTPSHKSTDSDLYSRPSSRTSMSSSTYGRPPSRAAESAIPIPSSRPMSRASSTRTPLSRPRSSMGVHNSVYSHGHSGSMSYTTTNEAADESLLEDDESDYRRTPTRRGGYETGIPLPGSGIPVRSRRPSGASSVSGMRRVSNARVYEDLGETY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3W5</accession>
    <name>G0S3W5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="10">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0039120</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="10"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS22027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694323.1">
        <property type="nucleotide sequence ID" value="XM_006694260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3W5"/>
    <dbReference type="STRING" id="759272.G0S3W5"/>
    <dbReference type="GeneID" id="18257950"/>
    <dbReference type="KEGG" id="cthr:CTHT_0039120"/>
    <dbReference type="eggNOG" id="KOG2099">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010198_1_1_1"/>
    <dbReference type="OMA" id="WLKQANP"/>
    <dbReference type="OrthoDB" id="9215500at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04300">
        <property type="entry name" value="GT35_Glycogen_Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000002">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000003">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468:SF3">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE, LIVER FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS22027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="885" mass="100604" checksum="CE0711F26D3F93E0" modified="2011-10-19" version="1">MTTATAIPHRERRPSVGAPIVDIQGNVGPAGISRPKHRRTHTGLGAGEIKIVEASIPEPQRETWRKHQAKPFADKDGFQRELVRHVETTLARSMFNCDESAAYSACALAFRDRLVYDWNRTQQRQTLADAKRVYYLSLEFLMGRALDNAMLNIGQKDIAKAGLAELGFRIEDVIEQENDAALGNGGLGRLAACFLDSLATLNYPAWGYGLRYRYGIFKQEIIDGYQVEVPDYWLDFNPWEFPRHDVTVDIQFYGHVVKTTDENGRVVHRWEGGETVKAVAYDVPIPGYGTSTTNNLRLWSSKAASGEFDFQKFNNGDYESSVADQQRAETISAVLYPNDNLDRGKELRLKQQYFWVAASLYDIVRRFKKSKRPWKEFPDQVAIQLNDTHPTLAIVELQRILVDIEGLGWDEAWDIVTRTFGYTNHTVLPEALEKWSVPLVQHLLPRHLQIIYDINLFFLQSVERQFPNDRDLLRRVSIIEETNPKMIRMAHLAIVGSHKVNGVAELHSDLIKTTIFKDFVDIYGPDKFTNVTNGITPRRWLHQANPRLSELIASKTGGYGFLTDLTQLNKLELHVNDADFRREWAEIKFNNKVRLAKYIKDTLGIAVNPNALFDVQVKRIHEYKRQQMNIFGAIHRYLTLKEMTPEERAKQQPRVSIFGGKAAPGYWMAKQIIHLINAVGEVVNNDKEIGDLLKVVFIPDYNVSKAEMIIPASDISEHISTAGTEASGTSNMKFVLNGGLIIGTCDGANIEITREIGDENIFLFGNLAENVEDLRHAHTYGGDWTLDPSLARVFEEIERGTFGNPQDFAAIISAVRDHGDYYLVSDDFHSYLETHKLVDEAYRDKEGWTTKSILSVARMGFFSSDRCINEYAEGIWNIEPLKGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0S465</accession>
    <name>G0S465_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycolipid transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0030870</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693535.1">
        <property type="nucleotide sequence ID" value="XM_006693472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S465"/>
    <dbReference type="STRING" id="759272.G0S465"/>
    <dbReference type="GeneID" id="18257125"/>
    <dbReference type="KEGG" id="cthr:CTHT_0030870"/>
    <dbReference type="eggNOG" id="KOG3221">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079400_0_0_1"/>
    <dbReference type="OMA" id="EMHGAEW"/>
    <dbReference type="OrthoDB" id="205255at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902387">
        <property type="term" value="F:ceramide 1-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902388">
        <property type="term" value="F:ceramide 1-phosphate transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3520.10:FF:000001">
        <property type="entry name" value="Pleckstrin domain-containing family A member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF25">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glycolipid transfer protein" evidence="2">
        <location>
            <begin position="32"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS21239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="206" mass="22680" checksum="6BE7B0652128B45E" modified="2011-10-19" version="1">MAVNIPPGGTVIDTFKGNFTKVPVDKSKGNAISTSEFLEAAESITTIFDLLGSVAFTPVKNDILGNVEKIRKRQLAAPLDSQNLQDLVRNELKTKSHTATEGLLWLGRGLEFLCAALTQNLNNPTEELSKSFGIAYEGTLKQYHNFVARGLFAAALKACPYRKDFYAKFGDDLQKVYAALKEYLAALEAIVAILKEFMTSPEAQWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0S492</accession>
    <name>G0S492_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CTLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0039350</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS22050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694346.1">
        <property type="nucleotide sequence ID" value="XM_006694283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S492"/>
    <dbReference type="STRING" id="759272.G0S492"/>
    <dbReference type="GeneID" id="18257973"/>
    <dbReference type="KEGG" id="cthr:CTHT_0039350"/>
    <dbReference type="eggNOG" id="KOG2659">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073203_0_0_1"/>
    <dbReference type="OMA" id="KMILWAQ"/>
    <dbReference type="OrthoDB" id="2415936at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH" evidence="3">
        <location>
            <begin position="77"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS22050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="243" mass="27506" checksum="89F6B87937D80113" modified="2011-10-19" version="1">MASATLSGAAQAPASLHPFDRRVAEMAVHKDDINRMILDYLTSMAHTKAALSFCREAKLDLQQSQEFVECRASIMMLILEGIVMKAISLLNEWDPELLDVDEELHFDLLQLHLIELIRMCQGKDPTPAVEFATNNLAPRAANNPKFLKKLEQTMALIIFPHNSLQPELAALLSPDLRRTVAYKVNMAMLRRRYPAHAEPSLLWLMRTRIHAEDVCRSKGRNLPEKIDLGMNPEGQDKPEPMDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5L5</accession>
    <name>G0S5L5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cysteine-rich interactor of PDZ three</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0024680</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692930.1">
        <property type="nucleotide sequence ID" value="XM_006692867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5L5"/>
    <dbReference type="STRING" id="759272.G0S5L5"/>
    <dbReference type="GeneID" id="18256506"/>
    <dbReference type="KEGG" id="cthr:CTHT_0024680"/>
    <dbReference type="HOGENOM" id="CLU_133934_2_2_1"/>
    <dbReference type="OMA" id="KKTEMYY"/>
    <dbReference type="OrthoDB" id="147332at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019367">
        <property type="entry name" value="PDZ-binding_CRIPT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10235">
        <property type="entry name" value="Cript"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS20634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="76" mass="8219" checksum="4FF2E806311B2863" modified="2011-10-19" version="1">MVCAKCQRLHKTVLATPEVKKKTEMYYGSPASSSSSTDKQKATLGQAGISKSKLLSKAAKNPFAQYSSSCLRCKMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5P4</accession>
    <name>G0S5P4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0024990</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692959.1">
        <property type="nucleotide sequence ID" value="XM_006692896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5P4"/>
    <dbReference type="GeneID" id="18256537"/>
    <dbReference type="KEGG" id="cthr:CTHT_0024990"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_13_6_1"/>
    <dbReference type="OMA" id="NEHVEDK"/>
    <dbReference type="OrthoDB" id="2533084at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF181">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="506"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="548"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="584"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="614"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="642"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="66"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="329"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS20663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="681" mass="75029" checksum="5E9BCDBA655E4752" modified="2011-10-19" version="1">MPGWKHAFSLPWAAVKAATPPGTVVLIEHGVTYRRGRYVNEVVKCPRPTEDPTDPLNWPGWFKVACMTTVAFYAFAANYISTAVAPALPIWNLQFPEEPRAMKDLMGFISFNVLVLGLGNIFWVPLSNIFGRRPVLVLSTLLLAVSTGLGMHLKGFKTTLILRILQGLGSSASETVVPAVVGDLFFVHERGKWMAFYTAFLASGSVLGGITGGYIAARMGWAKLFWIGAGLAGYALFSMLFSVPETLFERGGFMLPIQRNLPDPDEYRPRYRPSAQFSSRINQLKNRASTCQSLLADSRPLSSPAPAISLGTLPSARLTIPPDFQYHGPLDPPMTWYDPSSSSEELPTAAEPPARQTDGLTASSFRTAKYDNRFSCTTSTEEAPTSNWPSTRNSFAPIMTPAVRDKRAQPLAAPPEQQGEGWPLRSLPVRHKQTVLAFIKSLNWLGTYRGNWVHYLLKPWRTLRLPATWVVMLQYGGLVGSVAVISTVGPQILSLPPYSWGENTGLLFVGSLVGILLGAGCAALLVDWRLKRLAWNQDRGYAEPETRLAVMAPALVIGTSGLLVFGFCAQYPTKLGWLGLEFGNGMVAFALSQVPSIWFNYLIDAYDQLASDCFTIICVLRGLIPFAWTFFVTQWVERQGFLIPFGGFTAAMGLFSLLILPIIHLGKRMRIAMARYIVDNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5R4</accession>
    <name>G0S5R4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0033340</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693772.1">
        <property type="nucleotide sequence ID" value="XM_006693709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5R4"/>
    <dbReference type="STRING" id="759272.G0S5R4"/>
    <dbReference type="GeneID" id="18257372"/>
    <dbReference type="KEGG" id="cthr:CTHT_0033340"/>
    <dbReference type="eggNOG" id="KOG4733">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029565_0_0_1"/>
    <dbReference type="OMA" id="HGPRVHS"/>
    <dbReference type="OrthoDB" id="271725at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12243">
        <property type="entry name" value="RRM1_MSSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12244">
        <property type="entry name" value="RRM2_MSSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000468">
        <property type="entry name" value="Related to single-stranded DNA-binding protein MSSP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000323">
        <property type="entry name" value="RNA binding protein MSSP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="243"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="331"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="136"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="464"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="472"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS21476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="505" mass="54617" checksum="8DEACD6F41736E59" modified="2011-10-19" version="1">MPTDTNNRQGVYPSYLSSQHAGASQGDASAHHGQQAAHPTDAIGAVMNQFSTLALPAAPNLAAASNMTQIQAHPAYCGTQDQPVAYQGYSVPLQIGIAPEAYSFGVAGQFPVQGGFAPLPVPYAVPYTPGRVTSYADRSSDVPGLENRRGSYSTTESTPATPFFGSASERGSASRVAVFRSSYTTPSPEQIVAPKPHPQIDEEIIALVKQDPAIPEAVPAVFTPPSHQKTLEQCLENRIQGNRNVYIRGLHPTTDDELLLKYASRFGKVEQSKAIIDTSTGACKGFGFAKFADVRDSEKCIRGFYYLGYEVGFARESFNARLKAEGDETSTNLYLSNLPKRLNEAELNAIFAGYRVVSSKILRDSMGNSRGVGFARFETREECEDIIKKFHGAAIGEEGLLMQVRYADTPAQKELKRITAERRQFRTNEYNIGAYGTADVGIHPTIYNPPHWNRRTGMATNTTSVSMSTASDDGVTTDNATTTDSPTKKGAVSTQSSPTAKKEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5S4</accession>
    <name>G0S5S4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0033440</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693782.1">
        <property type="nucleotide sequence ID" value="XM_006693719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5S4"/>
    <dbReference type="STRING" id="759272.G0S5S4"/>
    <dbReference type="GeneID" id="18257382"/>
    <dbReference type="KEGG" id="cthr:CTHT_0033440"/>
    <dbReference type="eggNOG" id="KOG3108">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051033_0_1_1"/>
    <dbReference type="OMA" id="SFGNKRY"/>
    <dbReference type="OrthoDB" id="25571at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04478">
        <property type="entry name" value="RPA2_DBD_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040260">
        <property type="entry name" value="RFA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014646">
        <property type="entry name" value="Rfa2/RPA32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014892">
        <property type="entry name" value="RPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989">
        <property type="entry name" value="REPLICATION PROTEIN A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989:SF16">
        <property type="entry name" value="REPLICATION PROTEIN A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08784">
        <property type="entry name" value="RPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036949">
        <property type="entry name" value="RPA32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OB" evidence="7">
        <location>
            <begin position="70"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Replication protein A C-terminal" evidence="8">
        <location>
            <begin position="164"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS21486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="273" mass="29541" checksum="FBB2626E2EBE20D0" modified="2011-10-19" version="1">MGYASQGYGAQGGEDGGGFMTSSQQGSQGATKSKYAEDTLRPVTIKQILDCKEPYPGGDLTLDGAPISQVTFVGQVRSVNAQTTNITYTVDDGTGMIDVKKWIDADRINDEMNSNNHIVPDTYVRIFGRLTTYNNRKHIGAHCVRIIRDFNEVNYHLLEATYVHLLLTKGGPQRPGQTGAATVGDIGGDSMFVDQGFNSDVQAKLAACSPAARTVFNFLADNPMGGNEGVHVNLIASNTRLSYRDALDAGNELLSHGLIYCTMDDETWAVMEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5U3</accession>
    <name>G0S5U3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0033630</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693801.1">
        <property type="nucleotide sequence ID" value="XM_006693738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5U3"/>
    <dbReference type="GeneID" id="18257401"/>
    <dbReference type="KEGG" id="cthr:CTHT_0033630"/>
    <dbReference type="eggNOG" id="ENOG502RAI6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_190133_1_0_1"/>
    <dbReference type="OMA" id="ARWECTL"/>
    <dbReference type="OrthoDB" id="5221152at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="69" mass="7565" checksum="A1386D9F69731771" modified="2011-10-19" version="1">MPSKDQVYDLLQAQLQTKGIKFHIKTGGAKWECTLLDRNTHEKRKAERQGSTSSASSVTSSSSASTKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5X0</accession>
    <name>G0S5X0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dolichol phosphate-mannose biosynthesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0025220</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DPM2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692982.1">
        <property type="nucleotide sequence ID" value="XM_006692919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5X0"/>
    <dbReference type="STRING" id="759272.G0S5X0"/>
    <dbReference type="GeneID" id="18256560"/>
    <dbReference type="KEGG" id="cthr:CTHT_0025220"/>
    <dbReference type="eggNOG" id="KOG3488">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1767843_0_0_1"/>
    <dbReference type="OrthoDB" id="311279at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033185">
        <property type="term" value="C:dolichol-phosphate-mannose synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180047">
        <property type="term" value="P:dolichol phosphate mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009914">
        <property type="entry name" value="DPM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15039">
        <property type="entry name" value="DOLICHOL PHOSPHATE-MANNOSE BIOSYNTHESIS REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15039:SF11">
        <property type="entry name" value="DOLICHOL PHOSPHATE-MANNOSE BIOSYNTHESIS REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07297">
        <property type="entry name" value="DPM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS20686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="147" mass="15815" checksum="9C98D90CE3FADF39" modified="2011-10-19" version="1">MRGGMEMRTGAADGSAVVMQMRMCIDEAKRSSDCGDREAKIQALQPTPMGTLDKLVGLAMLVVATVVFLYYTIWTLLMPFVDSDHPLQNFFPPRVWAIRIPVILILLGSAVVGSFLSVVMIRSNRKKAAKAAAAAAAAGSTASKKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0S681</accession>
    <name>G0S681_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0025810</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="15 16 17" key="2">
        <citation type="journal article" date="2022" name="Sci. Adv." volume="8" first="eadc9952" last="eadc9952">
            <title>Conformational changes in mitochondrial complex I of the thermophilic eukaryote &lt;i&gt;Chaetomium thermophilum&lt;/i&gt;.</title>
            <authorList>
                <person name="Laube E."/>
                <person name="Meier-Credo J."/>
                <person name="Langer J.D."/>
                <person name="Kuhlbrandt W."/>
            </authorList>
            <dbReference type="PubMed" id="36427319"/>
            <dbReference type="DOI" id="10.1126/sciadv.adc9952"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.44 ANGSTROMS)</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB3 subunit family.</text>
    </comment>
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        <property type="protein sequence ID" value="EGS20745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006692978.1"/>
    </dbReference>
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        <property type="method" value="EM"/>
        <property type="resolution" value="2.77 A"/>
        <property type="chains" value="c=1-93"/>
    </dbReference>
    <dbReference type="PDB" id="7ZM8">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.76 A"/>
        <property type="chains" value="c=1-93"/>
    </dbReference>
    <dbReference type="PDB" id="7ZMB">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.75 A"/>
        <property type="chains" value="c=1-93"/>
    </dbReference>
    <dbReference type="PDB" id="7ZME">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.83 A"/>
        <property type="chains" value="c=1-93"/>
    </dbReference>
    <dbReference type="PDB" id="7ZMG">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.44 A"/>
        <property type="chains" value="c=1-93"/>
    </dbReference>
    <dbReference type="PDB" id="7ZMH">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.47 A"/>
        <property type="chains" value="c=1-93"/>
    </dbReference>
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    <dbReference type="EMDB" id="EMD-14791"/>
    <dbReference type="EMDB" id="EMD-14792"/>
    <dbReference type="EMDB" id="EMD-14794"/>
    <dbReference type="EMDB" id="EMD-14796"/>
    <dbReference type="EMDB" id="EMD-14797"/>
    <dbReference type="EMDB" id="EMD-14798"/>
    <dbReference type="SMR" id="G0S681"/>
    <dbReference type="STRING" id="759272.G0S681"/>
    <dbReference type="GeneID" id="18256619"/>
    <dbReference type="KEGG" id="cthr:CTHT_0025810"/>
    <dbReference type="eggNOG" id="ENOG502SBXP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145518_1_0_1"/>
    <dbReference type="OMA" id="VAFTAYC"/>
    <dbReference type="OrthoDB" id="521512at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012576">
        <property type="entry name" value="NDUFB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B12 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08122">
        <property type="entry name" value="NDUF_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="15 16 17" id="KW-0002">3D-structure</keyword>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS20745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="7ZM7"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="7ZM8"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PDB" id="7ZMB"/>
        </source>
    </evidence>
    <sequence length="93" mass="11130" checksum="92CCAECC70E52906" modified="2011-10-19" version="1">MQPTRILRNNGEKPNITGFDMREFLRHTKTPTYDPWERHEAWRYTGRFSRFNRFKGALPGFGIATVAFTAYCVFEHFFLKDDHHGHHGEKEHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0S689</accession>
    <name>G0S689_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">25S rRNA (uridine-N(3))-methyltransferase BMT5-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0025890</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693049.1">
        <property type="nucleotide sequence ID" value="XM_006692986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S689"/>
    <dbReference type="STRING" id="759272.G0S689"/>
    <dbReference type="GeneID" id="18256627"/>
    <dbReference type="KEGG" id="cthr:CTHT_0025890"/>
    <dbReference type="eggNOG" id="KOG4174">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035438_0_0_1"/>
    <dbReference type="OMA" id="KFMASAY"/>
    <dbReference type="OrthoDB" id="273345at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070042">
        <property type="term" value="F:rRNA (uridine-N3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019446">
        <property type="entry name" value="BMT5-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF26">
        <property type="entry name" value="FERREDOXIN-FOLD ANTICODON-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10354">
        <property type="entry name" value="BMT5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="25S rRNA (uridine-N(3))-methyltransferase BMT5-like" evidence="2">
        <location>
            <begin position="84"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS20753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="406" mass="44858" checksum="B2C39E0505038FBF" modified="2011-10-19" version="1">MGKARGLLKNAAKAVKQQHRANQAQKNQYRSQHQHQNPKNKPFSRPPPSKKQKTTHSKDNAASKHSQQQYQTPTLPFHPSDTILLVGEGDLSFAASLVTHHKCTNVTATVLEKDLAELSAKYPHVAQNISVIESSPQCRVMYGVNARKLPLFRSPSAPKKQPKRPYPDDDDDAPPGTMKRIIFNFPHVGGKSTDVNRQVRYNQELLVDFFRSAQPSLAPGGCIVVTLFEGEPYTLWNIRDLARHTGLQVERSFKFMASAYPGYAHARTLGVVKNKKGEVAKAAWKGEERPARSYVFVRKGEDSGLFTQGKKRKRSGGASDESESEGEGQDGQSGSEVEDTNEIENDGDDNDASAESEEENDADEGEQSDEEKDDIQESTVDVSDSDTDDNETTDQGKSSLTTKSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6D6</accession>
    <name>G0S6D6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0034540</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693887.1">
        <property type="nucleotide sequence ID" value="XM_006693824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6D6"/>
    <dbReference type="GeneID" id="18257492"/>
    <dbReference type="KEGG" id="cthr:CTHT_0034540"/>
    <dbReference type="HOGENOM" id="CLU_1077702_0_0_1"/>
    <dbReference type="OrthoDB" id="4572738at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="258" mass="29160" checksum="9CE1E831EB044441" modified="2011-10-19" version="1">MDEKDEITSRLTPPRPPDDSDSVQEYEVIEIEEDEEDESPRVPIRQALKQISRNYNSYSTNANASPYHAGDGFSEREAKPSGMNRLTRNGKLSSFSFYLGELDLAQSEPPSKPKRKARRVVFDNSFLPLPNKKPRRRLSNKQGTTEQEVKQERCSPAPISDNGLAEGQLDQQVKNASEEQQKLRSCNGAQHETFIAGAKEPGSCETRISESPPWRYHHEGRAASSAPDCEAKLKKQNDCLPFIFDFTDFGLLYFEFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6G6</accession>
    <name>G0S6G6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar import and degradation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0034850</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GID4/VID24 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693917.1">
        <property type="nucleotide sequence ID" value="XM_006693854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6G6"/>
    <dbReference type="STRING" id="759272.G0S6G6"/>
    <dbReference type="GeneID" id="18257523"/>
    <dbReference type="KEGG" id="cthr:CTHT_0034850"/>
    <dbReference type="eggNOG" id="KOG4635">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028759_0_1_1"/>
    <dbReference type="OMA" id="SSHTEFQ"/>
    <dbReference type="OrthoDB" id="62at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018618">
        <property type="entry name" value="GID4/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534:SF3">
        <property type="entry name" value="GID COMPLEX SUBUNIT 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09783">
        <property type="entry name" value="Vac_ImportDeg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00061469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS21621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="385" mass="43829" checksum="FFE8AD8C25D20782" modified="2011-10-19" version="1">MPRPSSNVSDTQSPRFFPSTCPESEEYQRSEVSSHTEFQGALSPESLSDWQPHAASQDLGGDGPSSPLHTMSPGPQSESVRDVEMGNDGERLPSPMRDEMDESHKRTDSNEAALTMRARSSRSLGNVRACDTNIRPVKTKSSGEPPGTSKQASDALPRSDSKIHNTDIWDMGRGPRWVEDSGLAGLAHEYSHMRLVLPNPSCYLRPGTRFVGTQQSKRQKYAVEVEFKHIDIRESFLCGYLRIQGLTSEDSTLITYFEGEIIGTKYGFITEQPAWGATPQIDVSHWEKFSPFEPYKPYVRKGQVYLKDAMQREYIFMRWKEHFLVPDHRVKMISGASFEGFYYICFNQIEGDVKGIYYHSRSEDFQQLELKCIQNRGLFASYEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6M3</accession>
    <name>G0S6M3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DNA ligase</fullName>
            <ecNumber evidence="16">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CTHT_0026720</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA ligase involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 16">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="16"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693130.1">
        <property type="nucleotide sequence ID" value="XM_006693067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6M3"/>
    <dbReference type="STRING" id="759272.G0S6M3"/>
    <dbReference type="GeneID" id="18256710"/>
    <dbReference type="KEGG" id="cthr:CTHT_0026720"/>
    <dbReference type="eggNOG" id="KOG0966">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004844_1_1_1"/>
    <dbReference type="OMA" id="EGIMIKH"/>
    <dbReference type="OrthoDB" id="19394at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032807">
        <property type="term" value="C:DNA ligase IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07903">
        <property type="entry name" value="Adenylation_DNA_ligase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07968">
        <property type="entry name" value="OBF_DNA_ligase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000234">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000013">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044125">
        <property type="entry name" value="Adenylation_DNA_ligase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029710">
        <property type="entry name" value="LIG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997:SF1">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 16" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="12 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="19">
        <location>
            <begin position="459"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="20">
        <location>
            <begin position="758"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="20">
        <location>
            <begin position="926"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="64"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00043870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EGS20834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1032" mass="116646" checksum="2966B9E52BD0E987" modified="2011-10-19" version="1">MSATKKRTKSPDPEAVEEDEKQYGNGPLTLEELDQQPRNHSKTFLFSELYKSLFNPLIECKPHPPGAATTATTAAAKGRPGRRGANPSKVSYHEQRRHIIERFMARWRADVGDDFYPAMRLILPDKDRDRGVYGLKESAIGRLLVKVMKIDRHSEDGYALMHWKLPGGAGGWKFGGGGGGGGGGGGNGKGAGTAGDFAARCYEIVGKRAMRTEPGNLTIADVNVMLDRLARANGEAEQLPIFEEFYRRMNAEELMWLVRIILKDMKVGATERTFFNLWHPDAEALFSVSSSLRRVCWELYDPEFRLEQEETGVTLMSCFQPQLAQFQMQGSFAKLVANLGVTEEEPEFWIEEKLDGERMQMHMMEDESVPGGFRFAFWSRKAKDYTYLYGNSLEDDKSALTRHLKNAFHPGVRNLILDGEMITWDPEVDKIMPFGTLKTAALEQQKNPFASGPRPLYRVFDILLLNDKSLTDYTLADRRRALERAVKGVPRRLEIHPYEKATSADAIEPALRKIISESSEGLVLKNPRSRYRLNSRNNDWIKVKPEYMSEHGESLDCVIIGGYYGSGRRGGTLSSFLCGVRVSENFTRSGAASKTEKCLSFCKVGGGFKGEDYAEIRHHTEGKWKDWDPSNPPSEYIELGGGERLQHERPDVWIRPSESVVISIKAASFGPSDQFATGYTLRFPRFRALRLDKAWDQAMDVDECDAIRTKVKEEEQERKAMEIENRKRRPTKRQKREIVVAGTDPNASAPLEFAVPLTNKQLFKGLEFCVLSEGLRPRKISKPELEELIKKHGGTIKQKVDPASVRGGGTIVLADKNVVRAASLKKAGGVDIVRPRWVFDCLERTGGEGYLLPFETDRHLLHATEGMKLVARDNTDAYGDSYARDVGIDELREILDRMNLPERSKEFDAGLFLDQLEEHGHGLEEMRSFLFRRCRVYFAVAEGKEGSETEVIRLGYYIRFGNGEIVESIKDRKDITHMVVVAGSKEQERIVAVDMRYKVSSWRAIPRIVTPKWVEDCWKEGTVVDEEAYAPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6X6</accession>
    <name>G0S6X6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MAPEG family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0027220</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693180.1">
        <property type="nucleotide sequence ID" value="XM_006693117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6X6"/>
    <dbReference type="GeneID" id="18256760"/>
    <dbReference type="KEGG" id="cthr:CTHT_0027220"/>
    <dbReference type="eggNOG" id="ENOG502S7P4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110778_0_2_1"/>
    <dbReference type="OMA" id="WLRTAIW"/>
    <dbReference type="OrthoDB" id="2122304at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35371:SF1">
        <property type="entry name" value="BLR7753 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35371">
        <property type="entry name" value="INNER MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS20884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="16704" checksum="F60B186FC83341BE" modified="2011-10-19" version="1">MASLIDFSSTNWSYYTIPAAFFLVMAPNFYAVALAGKNYDIAYPRTLESKVATDSSLPKPIQQRISRARAAAANGFETIGLYAAAVVAANSAQVPTEKLNKLTLTYIVSRAVYNFVYVALQENRKLAGLRPLVWGVGITVIMMLFVSAGQALNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6Z5</accession>
    <name>G0S6Z5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamine amidotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0035590</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693989.1">
        <property type="nucleotide sequence ID" value="XM_006693926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6Z5"/>
    <dbReference type="STRING" id="759272.G0S6Z5"/>
    <dbReference type="GeneID" id="18257597"/>
    <dbReference type="KEGG" id="cthr:CTHT_0035590"/>
    <dbReference type="eggNOG" id="KOG3179">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054974_0_2_1"/>
    <dbReference type="OMA" id="PWIQTLK"/>
    <dbReference type="OrthoDB" id="92161at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF5">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="1">
        <location>
            <begin position="66"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="249" mass="27594" checksum="5A51AD7E8F14B4E6" modified="2011-10-19" version="1">MSPLRLAVLEADTPVPRTFARHGGYAGVFSYLFERAVAPEPLSSLLTITAHDVVSGGAEAYPDPDTVDAILISGSKHNAFDNDEWIVRLVDYVRDVVQNQPRIKVIGICFGHQIVGRALGAKVGRSDKGWEISVTETELTEKGKEIFGGKKTLSLQQMHRDQVFTVPDGAELLASTDRCMNQGFLIPHRVITVQGHPEFTAEIMDELLELRHESGLFTDEMFEEARARNGDHHDGVFAAQALLKFLQDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G0S717</accession>
    <name>G0S717_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0035820</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694011.1">
        <property type="nucleotide sequence ID" value="XM_006693948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S717"/>
    <dbReference type="GeneID" id="18257620"/>
    <dbReference type="KEGG" id="cthr:CTHT_0035820"/>
    <dbReference type="eggNOG" id="ENOG502RJDG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1026726_0_0_1"/>
    <dbReference type="OMA" id="MARMEIS"/>
    <dbReference type="OrthoDB" id="5293596at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="271" mass="30863" checksum="5ED12EC44A2DD5DC" modified="2011-10-19" version="1">MPSQERTPLLAHSHNPSLGPEYPLLKDLLNIIDRLTRSSWGWLTHGKLVFSRGLILAYLTAVTPVLVYYKIKSHSATENGSPWASLFDFSTATYTWNWFLALLAFGWNFLKQRIRRHFRKGRHNVWEAAVLAKIAPSKGSSPYADFYLSLLYTAVQVSSYLNAIMYLAGGDGGETVSMPLDEEWLRGFYVINLYYVPALLSAIDTLVLNDVKRHEAWPYLALPMGFMSLKRSSSNKSIKEDSAARLTILMLKMARMEISLLKPERSPERRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7C7</accession>
    <name>G0S7C7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0036380</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694067.1">
        <property type="nucleotide sequence ID" value="XM_006694004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7C7"/>
    <dbReference type="STRING" id="759272.G0S7C7"/>
    <dbReference type="GeneID" id="18257676"/>
    <dbReference type="KEGG" id="cthr:CTHT_0036380"/>
    <dbReference type="eggNOG" id="ENOG502QUVP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105978_0_0_1"/>
    <dbReference type="OMA" id="NNTISTC"/>
    <dbReference type="OrthoDB" id="2141239at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408878" evidence="1">
        <location>
            <begin position="18"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="166" mass="17071" checksum="1C5E7E7437DC4E9E" modified="2011-10-19" version="1">MQTKAFVLVAIAGLAHARFGQEGAVQNLVQALSNFGPPGAAGTLAGRTPGVLLAGANACAKLELADEIVATLGDNPRVIEAAKALVAAEKNFNPFVQNIPTICNNPALPTTQALRGIVPKVDPAVVGADIQNANSQRSLTNPFNDNGLSVADISRAQGFSNFTDQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7G5</accession>
    <name>G0S7G5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Adenylate kinase isoenzyme 6 homolog</fullName>
            <shortName evidence="10">AK6</shortName>
            <ecNumber evidence="10">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Dual activity adenylate kinase/ATPase</fullName>
            <shortName evidence="10">AK/ATPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0028060</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with small ribosomal subunit protein uS11. Not a structural component of 43S pre-ribosomes, but transiently interacts with them by binding to uS11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the adenylate kinase family. AK6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="10"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693263.1">
        <property type="nucleotide sequence ID" value="XM_006693200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7G5"/>
    <dbReference type="STRING" id="759272.G0S7G5"/>
    <dbReference type="GeneID" id="18256844"/>
    <dbReference type="KEGG" id="cthr:CTHT_0028060"/>
    <dbReference type="eggNOG" id="KOG3347">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079096_3_1_1"/>
    <dbReference type="OMA" id="QCEIFGT"/>
    <dbReference type="OrthoDB" id="10251185at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000372">
        <property type="entry name" value="Adenylate kinase isoenzyme 6 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00039">
        <property type="entry name" value="Adenylate_kinase_AK6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020618">
        <property type="entry name" value="Adenyl_kinase_AK6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595:SF0">
        <property type="entry name" value="ADENYLATE KINASE ISOENZYME 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595">
        <property type="entry name" value="POS9-ACTIVATING FACTOR FAP7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13238">
        <property type="entry name" value="AAA_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 10" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMPbind" evidence="10">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="10">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS20967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="178" mass="20443" checksum="0451C392545C8F02" modified="2011-10-19" version="1">MAPPRSLPNIIITGTPGTGKTSHAELLAERTGLKHISINQIVKDKECHEGYDEEYQSWIVDEDKLLDAIEDEVTKGGCIIDWHACDLFPKSWIDLVVVLRVDTATLYDRLTERKYPEKKLQENIDAEIMDVLIQEAREAYDEEIVVELESVTTDQMESNVERIEQWLKQWKEDNGVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7H9</accession>
    <name>G0S7H9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative vacuolar protein sorting-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0028200</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OB-RGRP/VPS55 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693277.1">
        <property type="nucleotide sequence ID" value="XM_006693214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7H9"/>
    <dbReference type="STRING" id="759272.G0S7H9"/>
    <dbReference type="GeneID" id="18256858"/>
    <dbReference type="KEGG" id="cthr:CTHT_0028200"/>
    <dbReference type="eggNOG" id="KOG2174">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134810_0_1_1"/>
    <dbReference type="OMA" id="RSHVDMT"/>
    <dbReference type="OrthoDB" id="14246at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034424">
        <property type="term" value="C:Vps55/Vps68 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007262">
        <property type="entry name" value="Vps55/LEPROT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050">
        <property type="entry name" value="LEPTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050:SF0">
        <property type="entry name" value="RH04491P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04133">
        <property type="entry name" value="Vps55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS20981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="129" mass="13820" checksum="66085E28EFBA9883" modified="2011-10-19" version="1">MPQAGLKTIISLSFVLAIGFLLVILSCALWKAYYPLLVVATYVLAPVPNWICGHCANPDDFVESSGAAVLDLGRFCTGFLVVMGVALPVLLCHSGLISTPAMIMSIIGGLLIYGTIISFAMFFQEDQDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7N8</accession>
    <name>G0S7N8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Aprataxin-like protein</fullName>
            <ecNumber evidence="4">3.6.1.71</ecNumber>
            <ecNumber evidence="3">3.6.1.72</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Hit family protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CTHT_0036990</name>
    </gene>
    <organism evidence="24">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 3'-end 2'-deoxyribonucleotide-3'-diphospho-5'-guanosine-DNA + H2O = a 3'-end 2'-deoxyribonucleotide 3'-phosphate-DNA + GMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:52140"/>
            <dbReference type="Rhea" id="RHEA-COMP:13186"/>
            <dbReference type="Rhea" id="RHEA-COMP:13187"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:136419"/>
            <dbReference type="ChEBI" id="CHEBI:136420"/>
            <dbReference type="EC" id="3.6.1.72"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 5'-end adenosine-5'-diphospho-5'-2'-deoxyribonucleoside-DNA + H2O = a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + AMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:52128"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:13181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:136413"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.6.1.71"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 5'-end adenosine-5'-diphospho-5'-ribonucleoside-2'-deoxyribonucleotide-DNA + H2O = a 5'-end 5'-phospho-ribonucleoside-2'-deoxyribonucleotide-DNA + AMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:52132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13182"/>
            <dbReference type="Rhea" id="RHEA-COMP:13183"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136414"/>
            <dbReference type="ChEBI" id="CHEBI:136415"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.6.1.71"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.1.71" evidence="4"/>
    <dbReference type="EC" id="3.6.1.72" evidence="3"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694125.1">
        <property type="nucleotide sequence ID" value="XM_006694062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7N8"/>
    <dbReference type="STRING" id="759272.G0S7N8"/>
    <dbReference type="GeneID" id="18257737"/>
    <dbReference type="KEGG" id="cthr:CTHT_0036990"/>
    <dbReference type="eggNOG" id="KOG0562">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066882_0_0_1"/>
    <dbReference type="OMA" id="IHDMFPK"/>
    <dbReference type="OrthoDB" id="3512845at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033699">
        <property type="term" value="F:DNA 5'-adenosine monophosphate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120108">
        <property type="term" value="F:DNA-3'-diphospho-5'-guanosine diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990165">
        <property type="term" value="F:single-strand break-containing DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000012">
        <property type="term" value="P:single strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000017">
        <property type="entry name" value="Aprataxin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032566">
        <property type="entry name" value="Znf-C2HE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486:SF4">
        <property type="entry name" value="APRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486">
        <property type="entry name" value="APRATAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16278">
        <property type="entry name" value="zf-C2HE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT" evidence="21">
        <location>
            <begin position="99"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Aprataxin C2HE/C2H2/C2HC zinc finger" evidence="22">
        <location>
            <begin position="240"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00059438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00076243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF16278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EGS21829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="302" mass="34629" checksum="CE7354F0F3090012" modified="2011-10-19" version="1">MPEAEIPEEMDEFVQPESAPPTVDSPEVPVDHDATKTVSSVLETFTSTKKDAFAELMSHKQPSKKLMKPPRSLAEKAGKVIGGVWRGALGPFIEHPEKYPDQVLRVTEHTVLIKDRYPKATIHLLLLPRSKEHNLLHPHTAMADPAFLKIMRAEAETAAQLAAAELQRLLGRFSEKNRSRNEAIDACVPFDELPPGRDYRKDIRVGTHAHPSMAHVHVHIISRDMRSESLKRVKHYNSFNTPFFIPLEDYPLGEEDERWSTSYQNNNLTGDMVCWRCKKNFGHKFAELKRHLEEEFEAWKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7R0</accession>
    <name>G0S7R0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5'-3' exoribonuclease 1</fullName>
            <ecNumber evidence="5">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0028500</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the 5'-3' exonuclease family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="5"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693306.1">
        <property type="nucleotide sequence ID" value="XM_006693243.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S7R0"/>
    <dbReference type="GeneID" id="18256888"/>
    <dbReference type="KEGG" id="cthr:CTHT_0028500"/>
    <dbReference type="eggNOG" id="KOG2045">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001581_1_2_1"/>
    <dbReference type="OMA" id="VASWPWF"/>
    <dbReference type="OrthoDB" id="372487at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000002">
        <property type="entry name" value="5'-3' exoribonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016494">
        <property type="entry name" value="5_3_exoribonuclease_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041385">
        <property type="entry name" value="SH3_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040992">
        <property type="entry name" value="XRN1_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047007">
        <property type="entry name" value="XRN1_D1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041106">
        <property type="entry name" value="XRN1_D2_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047008">
        <property type="entry name" value="XRN1_SH3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF7">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18129">
        <property type="entry name" value="SH3_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18332">
        <property type="entry name" value="XRN1_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18334">
        <property type="entry name" value="XRN1_D2_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006743">
        <property type="entry name" value="Exonuclease_Xnr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="1 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Xrn1 N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 D1" evidence="10">
        <location>
            <begin position="718"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease Xrn1 D2/D3" evidence="11">
        <location>
            <begin position="910"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 SH3-like" evidence="9">
        <location>
            <begin position="1154"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1262"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1318"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1342"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1414"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1439"/>
            <end position="1461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS21010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1461" mass="163834" checksum="1DC0D3E70FFB648A" modified="2011-10-19" version="1">MGVPKFFRWLSERYPAISQLIAENRIPEFDCLYLDMNGIIHNCTHKDVDDVHFRLTEEEMFIAIFNYIEHLFGKIKPKKLFFMAVDGVAPRAKMNQQRARRFRTALDAERAREKALREGKELPKEEPFDSNCITPGTEFMAKLSLQLKYFINKKVSEDRDWQGPEIVLSGHEVPGEGEHKIMEYIRNARAQPDYNPNTRHCLYGLDADLIMLGLLSHDPHFCLLREEVTFGRQAKHKSKELEHQNFYLLHLCIVREYLELEFQELKEPGAIPFPFDMERVIDDFILMAFFVGNDFLPNLPRLHINEGALALMFKIYKKVLPKCDGYINENGKVNLDRLKILLEELEQEEYRFFEQEHEDTKWLQGKKMLENNEAEQAKAKAKGKLIISPSQKALWKQKIRKWLLNSTSPTLDLGADLNAADRKFVEDLAEAAHIEWATKPDDDGIRHLVLSRPVMDEDDEEDEEAHAALYRIAKRYDNAQVLDLSSEEAKAAVQEKYKQKFQEWKDKYYLSKMDGWTPQNLEQELKKMAENYVQGLQWVLYYYYRGIASWPWFYGYHYAPMISDVVKGLGADLNFKLGQPFRPNEQLMGVLPDRSKKIVPKVYWDLMTDPNSPIIDFYPREFELDLNGKKMDWEAVVKIPFIDEKRLLEAMAPRNALLTEEEKARNEFGVPLKFTYSEDVDFVYPSSLVDVFPPIFHCHCVENIFDLPPMEGLEYRAGLAEGALLNVEALAGFPTLATLPYTASLAFHGVNVFQQESRNESMIVRLTDSHLRTKIDTAKVKLGQRCFVGYPFLQEAKVVAVSDELFEYTLASDGSGQVIERHHTPREIEEWKKKAERIENFYSKRLGILIGPVESLVTVHMLKGLRKTDEGATVKEYGEVPGMETDYAAQIIVDEVVNEDERFIEQAALPIEEEFPVKSNGFFVGDYNYGQPLEVVGYTKDGKLSIWLAVPTAREPEFAKQIIHEAHRSQLYQPSYMVAKQLGLHPLTLSKITSSYYVRTVGDLRVNLGLNLKFESKKQKVLGYSSKSATGWEFSQAAVLLISEYMRRFPDFFAAIVKNPSGSELNETDLFPDPAYATARVKEIGAWLKTLKTSSMERVPLDAEQLDSDVVMRLAAKADELGLGNQQTVSKKMNGVPRNAVIRPEDAEHRLGNQVFSLGDRVVYVARKGKVPIAFRGTVVGISRTPTNKLIDVVFDVTFLSGTTLGDRCPPFRGQTVPSNVLLNLTNRQLVVETKAGQLRRAPINPSVTTLTAHGGYMLNGKKYRDAPAPPPLQAPYRSVVNGSANSRGGANTPRGGSRGGGRNGSPAHANLPHRPAPQHQNHQPQQSHPQQQINGHHAPGGARGGRGGPAGTLPFRGGRGGGAPRAGFATPQRGGAGFLPGNVGAGIPHPASAPPMYSAVPPPPSLDAPARGSGRGRGRGGVARGGNRGGRGRGGVSRGSVPAAQAASQPPQVAASASQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7T2</accession>
    <name>G0S7T2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin interaction domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0028720</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693328.1">
        <property type="nucleotide sequence ID" value="XM_006693265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7T2"/>
    <dbReference type="GeneID" id="18256910"/>
    <dbReference type="KEGG" id="cthr:CTHT_0028720"/>
    <dbReference type="eggNOG" id="ENOG502S0Z0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005620_1_1_1"/>
    <dbReference type="OMA" id="WAMTLFN"/>
    <dbReference type="OrthoDB" id="4489171at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055335">
        <property type="entry name" value="Ucp6/RUP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39597">
        <property type="entry name" value="UBA DOMAIN-CONTAINING PROTEIN RUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39597:SF1">
        <property type="entry name" value="UBA DOMAIN-CONTAINING PROTEIN RUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="722"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="805"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="737"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="852"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="903"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="959" mass="106945" checksum="FB092E0680D358B0" modified="2011-10-19" version="1">MAAVDQASIDMVVEVIGHIDKSLIANALRANHGNVETVIIEWFDDSDKFRRKYAWDESAFASNREGDRPAGSGGPSFVIHPPDNDVIYGTEPGGYYAPSRPPSRANNRSPMSRVVDLTAGDYTTDAPTSRQEEEDHLQRAINESLQTSGMPTPHMMAFPPPPAPHSQQSGITSNNDNPVYFGPANRPDYDPDEWAMVRVKTYGPDPDPALRVRKPGAPVLLRCRDEGWNKHRLGAMLMVYNQIPAARNLLLRCGGPPGYGLGNKSDWWKGETIFPPGMAPDSNGWGAEPSPNWVDELLRILAFMDSTDRSYGTADMLAKAKHPDVDETGDVEKDFIKSVMVAHNAQGTGKDLEVLVASAEVVSFDNLVPQTNEFFGILDLQLGSPINPVAPRSLYEVFDYIFMVNLRYHMDDPSTGRMAWILNPSEVLTLRFTGDESFPSQLEIPDTFYLDRYLKYNGTQFQRLQLDMMTVLKLLDAYFQEEESLVRWINPKTNRAYDRRAILKAAVRRCQERITKIKNKAFWRQHEEGSSTRKEEYYLPDHSGEPQFTEEEAKVVAYYKSKITEFEVELANIESSLNERVVPQKQKLQALLRRMQSSMTEPEPDHNWNPTHKYSLRGVISDPNTVFIRIREPLQPDDLLDDEAAAFTMDRWWKVSYNAEEGVEHNQVSWEVVKREGCGSKPAPMLIYATEKALEQEPLPLPDALKTFVRFDNHLFKQELAQSSHSMDKKRSAMPALNSQSKRLQRSNSMDSMASNRASMGDSDNEMHDAPVFNRGSVFSTGDFAAYQPRSSSINLIDLEDDESTTLVQDPLSPHALPHSLSGDCSNLPPPPPYDSISGGDVEMQGMGYASFPPPPGHSAPPPPFPPPPPPPHPPALDPGLDGLAQVSLASSPPKVSTALDESSPRKTAVDRSVDGVTKESDAVNGRTDPCDTDNTTDEQKAEHNQTPPVAPEQVRFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7V3</accession>
    <name>G0S7V3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0028930</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693349.1">
        <property type="nucleotide sequence ID" value="XM_006693286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7V3"/>
    <dbReference type="GeneID" id="18256931"/>
    <dbReference type="KEGG" id="cthr:CTHT_0028930"/>
    <dbReference type="HOGENOM" id="CLU_1011957_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="244"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS21053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="275" mass="29460" checksum="F090988CAA6F3212" modified="2011-10-19" version="1">MDDTTQPRVLNGSLRNERSAVSPMPSGSIIRGSLQSPPRSNPDEASMIPTPLSPQLSPGIRASSPEFDRGHQLEGLAQATYESSAAPITTPVSNANSVSNIDSSSSHYPTARDRLNAIFPPLNLTLPSTQTPLPALEDMEDKIQKMEREMAHIRAELSRMEQSCWMWRDRAQRAELKVRELEAKVEADFAAIEAVLAEPLPPPPWKRASDNGAASPSGSLNDASIVAVAGSDAESRDTVGIIATGLGSSAGQPKDEDEKTGVKGPKVSAFEEHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0S839</accession>
    <name>G0S839_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RWD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0029270</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IMPACT family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693382.1">
        <property type="nucleotide sequence ID" value="XM_006693319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S839"/>
    <dbReference type="STRING" id="759272.G0S839"/>
    <dbReference type="GeneID" id="18256965"/>
    <dbReference type="KEGG" id="cthr:CTHT_0029270"/>
    <dbReference type="eggNOG" id="KOG3299">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045276_0_1_1"/>
    <dbReference type="OMA" id="HLMQVMD"/>
    <dbReference type="OrthoDB" id="69641at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140469">
        <property type="term" value="P:GCN2-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23822">
        <property type="entry name" value="RWD_ScYIH1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="entry name" value="Impact, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020569">
        <property type="entry name" value="UPF0029_Impact_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="IMPACT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301:SF25">
        <property type="entry name" value="PROTEIN IMPACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="Impact_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00910">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="5" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="RWD" evidence="8">
        <location>
            <begin position="7"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="114"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS21086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="292" mass="32030" checksum="1380D09C9E6D8755" modified="2011-10-19" version="1">MSEALLDEIEAINSIYGDNTLVRSPQDSGPTIYILTLPGETASLRLQFPPEYPDVPLTVLGTHSSGSSGKRGTAARDLALFRDAVSEVYEAGQVCLFDAIEKVQELLAAVKEEEEREQKEREEQAASQSDDEGNEGVTPNRDGRHTDELPILSSPPPWTLSEPITESKSTFIARCAPVTSPQQAVSYMQHLLATDKKVRAATHNMTAWRIRGLNGTSFQDCDDDGETAAGGRLLHLMQRMDLWDVMVVVSRWYGGVKLGPRRFTLINQVARDAFVQAGLVSNSGEKKKKGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G0S840</accession>
    <name>G0S840_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Putative gamma-glutamylcyclotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0029280</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gamma-glutamylcyclotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693383.1">
        <property type="nucleotide sequence ID" value="XM_006693320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S840"/>
    <dbReference type="GeneID" id="18256966"/>
    <dbReference type="KEGG" id="cthr:CTHT_0029280"/>
    <dbReference type="eggNOG" id="ENOG502S7T1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093936_1_2_1"/>
    <dbReference type="OMA" id="DPEPWQK"/>
    <dbReference type="OrthoDB" id="1044435at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045038">
        <property type="entry name" value="AIG2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31544">
        <property type="entry name" value="AIG2-LIKE PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31544:SF2">
        <property type="entry name" value="AIG2-LIKE PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Gamma-glutamylcyclotransferase AIG2-like" evidence="4">
        <location>
            <begin position="18"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS21087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="169" mass="19633" checksum="601639FCB21E674A" modified="2011-10-19" version="1">MGSPVESKDVEEPAKCGFFYGTLMAPEVFFTVCYDTKNVPEEVKKRHNFHEAILHGYCRRRVRNADYPGITEDKEHTVRGIYVTGLSAHNMARLDFFEGSEYERRTVTVRLLEKIDKGDGTFELVEGEERTAEVYVFLPTGGLEGDEWDYEQFRREKMAYWTRAGYGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8C3</accession>
    <name>G0S8C3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alcohol dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="9">1.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0021230</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a primary alcohol + NADP(+) = an aldehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15937"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:15938"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:15939"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.2" evidence="9"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692594.1">
        <property type="nucleotide sequence ID" value="XM_006692531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8C3"/>
    <dbReference type="STRING" id="759272.G0S8C3"/>
    <dbReference type="GeneID" id="18256161"/>
    <dbReference type="KEGG" id="cthr:CTHT_0021230"/>
    <dbReference type="eggNOG" id="KOG0023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_20_2_1"/>
    <dbReference type="OMA" id="GWGEQKF"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008106">
        <property type="term" value="F:alcohol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000158">
        <property type="entry name" value="Zinc-binding alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056121">
        <property type="entry name" value="DUF7704"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24803">
        <property type="entry name" value="DUF7704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="13">
        <location>
            <begin position="161"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS20298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="507" mass="55851" checksum="775F1E6E8D6BD013" modified="2011-10-19" version="1">MITKRPITPTVSISGFPLPLPYRLFFLLVEPLATLAGAYYAHFDQQTYLTLSHAPSAPFTIPLGMSITMSQLGNMYFAFAMIEALVLRSTSDLRVWKTLLFCLLVADVGHLLSIRALGTQIYWNVAVWNAIDWGNVLFVYVGRAAVEMPYPETFTGFQVHGPDTWLEFHKNEFTPKPFGDYDVDIKIECCGVCASDIHTISGGWGKQHYPLAVGHEIVGTAIRVGPKVTLVKVGQRVGVGAQSWSCLDCRQCKNDNETYCRKQLDTYGAVWPDTGIVSQGGYSSHVRTHEHWVFPIPDALPSTIAAPMLCAGLTAYSPLVRNGASPGKKVGIVGLGGIGHLAVLFSKALGAKTWVISRSHAKESDAFALGADGYLATSDPNWNEPHVMTFDLIINTANSFEGFDLDAYLSLLDVHAKWVNVGLPEGDVRVKSQTFLKNGCFFGTSHLGSRREMLEMLGLAAEKGIRTWVEEVKIGEEGLRKALGRLHRGDVRYRFVLTGYQEVFGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8G8</accession>
    <name>G0S8G8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0029830</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693438.1">
        <property type="nucleotide sequence ID" value="XM_006693375.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S8G8"/>
    <dbReference type="GeneID" id="18257021"/>
    <dbReference type="KEGG" id="cthr:CTHT_0029830"/>
    <dbReference type="eggNOG" id="ENOG502QVPZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003539_0_0_1"/>
    <dbReference type="OMA" id="ARDHPRC"/>
    <dbReference type="OrthoDB" id="20774at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="2">
        <location>
            <begin position="60"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="3">
        <location>
            <begin position="564"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1112"/>
            <end position="1139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS21142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1340" mass="149581" checksum="1ACCB4956445F6BE" modified="2011-10-19" version="1">MALHTNVLHNGEWVTQTIDVYSILSKQTPSSSKKQTTREQLPPPTCGLLTTTISESPHIKHILPVRLRSLRHNDVAIIGLGPDGRLKEVIRRNDFDCQIRNACVIGTFSLDDLREASFETRIKTEEDEFCFSAGPAGHHHPLPPQLLAVFLENGEIIFMFVRENAERKLEFVTGKYEDNIHHALSNDYSGFYVAVDPSSRYMAMASVDYIVIYELEEREVLAERYSRGQPLKPVKTHRLRHTPGSVVNMTFLYPQLGHPGHIILLMIIANNGRPKGYVLDWILGEKLPNVVSRIGLNKFGIPPEHCCPTLLIPLRVESAYISVSGKHLALVTGAVHGAPIHERLSSLQNEPPAFPYHNRTTREPLWVAWARPLRYSSFYSGKDSRGNPPKDFFYLARHDGLVIHIEAKREDQDSVSLSLNILESFPCSMDVGLFACLCEDQAFDILVLGSTNGPGGYWKTLPLGPVVFLGELPYWGPVYDFTTTDEFIDCEGGSQHKAMVPWQEGTVRRPDRVFAAVDMGKKGAIVEYRYGLKADIGLDIDWPGAVKRVWLVSGHHPFSHQGYLLLLSGVDRSAAVYMSYDFGDAEEKTVDDGVPFDLSSPTFAMACSAPMVVQVTRQSIVLAAYGRSIRVPVQEISGLVDAEVSDACIRDDCIALSVLRQARYVIQILKIDTSTLRVAPVHELEVDGEVTALGLDADYTLLVGVRRNLQTSLDYCSLTNPLGGFETVNLTEYLVEQIGPLLPEGPPVAEGIADILPLKGMVLLGTRSGEVIILRNVDGSVLIESEKFGSAVAHLTYSSRSGENGSSVLITCDNALVSMSLDVAYTGTQAILKSKKHRVWPVDSQALHELAPPVQFAMALDVPADDSVTPLLMVSSSRLLLAELHHTPGLVNRVLTVNGTPTRVMYSHAMQSLIVGMVREGRPDLVFLHPDTGEHIGRPQNKQGAPIDSLQAFDKFGDRIFTLTEWTYKKDHGVWNLLLIGLKMGLLLVVRMDKDTHGGHLTIRYRLLYKRDYGEPVYSAIGYDAGIVCCAGDLIRWEVLDPEDKKLRPLREFPINSPGIALRIANGKLFCLTKSDSLAVLEHGNGTEPTTKLCHVDPYRTESWHMIMVESPEPEQQQQQHSAIEGEGSEENQQHQGKRGAMVLTADRFNGIGATWVPWLTKEQETHLVVNSELRVGSIRRFRRGRTRPVWQQYQGRCRPRYGRLAATIDDADILAVTFLGSVIQMSLLNPDAWRLLKYIANLAFADEEICPYLCFGEDKEEQARVRKDPEPREEAEERWVDGDLLRRVVERGILGRLVRGREERVKELLGKVEGRERENVEAVVRGVEEVLGYYLEVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8Z6</accession>
    <name>G0S8Z6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">mRNA cap guanine-N(7) methyltransferase</fullName>
            <ecNumber evidence="3 15">2.1.1.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 15">mRNA (guanine-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 15">mRNA cap methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CTHT_0044000</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Responsible for methylating the 5'-cap structure of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:67008"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.1.1.56"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.56" evidence="3 15"/>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694792.1">
        <property type="nucleotide sequence ID" value="XM_006694729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8Z6"/>
    <dbReference type="SMR" id="G0S8Z6"/>
    <dbReference type="STRING" id="759272.G0S8Z6"/>
    <dbReference type="GeneID" id="18258438"/>
    <dbReference type="KEGG" id="cthr:CTHT_0044000"/>
    <dbReference type="eggNOG" id="KOG1975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020346_3_1_1"/>
    <dbReference type="OMA" id="LITGDCF"/>
    <dbReference type="OrthoDB" id="10248867at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004482">
        <property type="term" value="F:mRNA 5'-cap (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004971">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016899">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039753">
        <property type="entry name" value="RG7MT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189:SF2">
        <property type="entry name" value="MRNA CAP GUANINE-N7 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189">
        <property type="entry name" value="MRNA GUANINE-7- METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03291">
        <property type="entry name" value="mRNA_G-N7_MeTrfase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028762">
        <property type="entry name" value="ABD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51562">
        <property type="entry name" value="RNA_CAP0_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9 15 16" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="5 15" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MRNA cap 0 methyltransferase" evidence="18">
        <location>
            <begin position="149"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="360"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="368"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="158"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>mRNA</name>
            <dbReference type="ChEBI" id="CHEBI:33699"/>
        </ligand>
        <ligandPart>
            <name>mRNA cap</name>
        </ligandPart>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="16">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="16">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="16">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="16">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="16">
        <location>
            <position position="442"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="16">
        <location>
            <position position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR028762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR028762-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGS19907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="518" mass="57891" checksum="DE346840BB74E27E" modified="2011-10-19" version="1">MSSTKQIKATTQDDNDPIPQPFDAKKLAPAKKRPCSPSEGQPDKKIKLSDSVASTNASASAASASGSTSNNTPSGSGEAPRKLKRPGQRARISEAEREQIRQRALERERQLREATEQQEQQQRQSINDIVRTHYNSVPERGREWRKTESRIKGLRAFNNWVKSCLIQKFSPDEDYTPGALERGLHSGNRLLVLDIGCGKGGDLFKWQQAPQKVDLYVGLDPAEVSIEQARERYRNMANRGGGGGRGGRGGHHRRPPRTFEARFHVKDCFSESIGDIDIVRQVGFTTSPLASSRGFDVVSMMFCMHYAFESEEKARQMLKNVAGALKKGGRFIGCIPNSDVISAKVVEFNKKLQEKKKKKKFQAAQAAGSSEPSQDGASTSDPDSKQKDATEEGEAEDDTAQWGNSIYRVRFPGATPADGIFRPPFGWKYNFFLDEAVEEVPEYVVPWEAFRALAEDYNLELQYHKPFADVWAAEKDDRELGALSERMGVRSRETGELLVTPEEMEAASFYVAFCFYRV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2013-12-11" modified="2025-04-09" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0S920</accession>
    <name>REI1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName>Cytoplasmic 60S subunit biogenesis factor REI1 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>pre-60S factor REI1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">CTHT_0044240</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Pre-60S-associated factor involved in the cytoplasmic maturation of the 60S subunit. Involved in the dissociation and recycling of other late pre-60S factors before newly synthesized large ribosomal subunits enter translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associates with nascent pre-60S particles that have not yet entered the translating pool, and is released from mature 60S subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the REI1 family.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="EGS19931" version="1"/>
        </conflict>
        <text>Truncated N-terminus.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19931.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694816.1">
        <property type="nucleotide sequence ID" value="XM_006694753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S920"/>
    <dbReference type="STRING" id="759272.G0S920"/>
    <dbReference type="GeneID" id="18258462"/>
    <dbReference type="KEGG" id="cthr:CTHT_0044240"/>
    <dbReference type="eggNOG" id="KOG2785">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018787_1_2_1"/>
    <dbReference type="OrthoDB" id="19329at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040025">
        <property type="entry name" value="Znf622/Rei1/Reh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182:SF8">
        <property type="entry name" value="CYTOPLASMIC 60S SUBUNIT BIOGENESIS FACTOR ZNF622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182">
        <property type="entry name" value="ZINC FINGER PROTEIN 622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000424593" description="Cytoplasmic 60S subunit biogenesis factor REI1 homolog">
        <location>
            <begin position="1"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C2H2-type 1">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C2H2-type 2">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C2H2-type 3">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="163"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="312"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="323"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="340"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="383"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P38344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="537" mass="61196" checksum="2BB080182EFFA13F" modified="2013-12-11" version="2">MATIAGSRAPTEVPSHPYTCNTCQVAFRNSELQRGHMRSDWHRYNLKRRVASLPPISSEVFTEKVLQARAATTAQADKAGFEKTCEVCQKTYYSENSFRNHLSSTKHKSKAAAAARRPANNKVDDDVSSMSFSLGEPARADSVVDSEAEEEFSEVVEGIKNASIHDTASPIKRPSAPQPAVEEQSKTDAQMEETPTTTPKPEALTPSATTCVFCNYESPTPQLNASHMERIHGMFIPEKQYLVDLEGLLKHLWEKVFRYNECLTCGKMKVNVFAIQTHMRDKSHYHIPYTTEEEQLEIGEFYDFRSTYSDGDWETEEEDKGEEDGGVRLGAKRESKVVDENGDEVMEDEEGWETDSDASSLDTDDLHAVPAEGHYHQYERLGKHPHHSRENKKAHREADGIHAPSKRTHAVYYDEYELHLPSGKSVGHRSLARYYRQNLYHYPTPEERAERLAIEAAERENRMDVDGEEPERGRTRTRALVPRDIKGLGVTTMSDPRVRGIVQKGKKEEWKNRDSKWWMHSQVAIKEKAKHPSTYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0S951</accession>
    <name>G0S951_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0044570</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694847.1">
        <property type="nucleotide sequence ID" value="XM_006694784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S951"/>
    <dbReference type="STRING" id="759272.G0S951"/>
    <dbReference type="GeneID" id="18258495"/>
    <dbReference type="KEGG" id="cthr:CTHT_0044570"/>
    <dbReference type="eggNOG" id="ENOG502S00E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107695_0_0_1"/>
    <dbReference type="OMA" id="EINCIQQ"/>
    <dbReference type="OrthoDB" id="9980836at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="1">
        <location>
            <begin position="36"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="216" mass="24236" checksum="E5970B60A5AED4B0" modified="2011-10-19" version="1">MSSTHSAETLISTFLQVTEDRIVPLTRSGVSSGSKVFGAAILNRLDLSPVTVSTNNERVSPLLHGEINCIQEFFASPAEGRPATRDCVFFATHEPCSLCLSGITWAGFNQFYYLFTYEDSRDLFSIPYDIDILQEVFRVPAPSDTPETLAARPLYNRKNKFFTAKSLADLLQDIPDETQRRHWAAEIERVKGLYSSLNERYQQGKQAGAESASIWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0S961</accession>
    <name>G0S961_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0044680</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694857.1">
        <property type="nucleotide sequence ID" value="XM_006694794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S961"/>
    <dbReference type="STRING" id="759272.G0S961"/>
    <dbReference type="GeneID" id="18258506"/>
    <dbReference type="KEGG" id="cthr:CTHT_0044680"/>
    <dbReference type="eggNOG" id="KOG1726">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048918_1_0_1"/>
    <dbReference type="OMA" id="WMPWGWG"/>
    <dbReference type="OrthoDB" id="434647at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF177">
        <property type="entry name" value="PROTEIN YOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="262"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="316"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS19972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="335" mass="36550" checksum="3395144A481C462F" modified="2011-10-19" version="1">MFGIFAHFLSSVASFLFPIFASYKALKAGDPSQLTPWLMYWVVLSIALLIESWLGWFLFFVPFYSYARLLFMLYLVLPQTQGARTIYEEYVHPRLEENEAAIEEFIASAHERLKAAGMEYLKRAIEAVRVNVLGLPPSPPEQPQPAQQTPQGYTASLLARFSLPSPRWMSGTGAQPQTGTWTGTAAGNDFYSLLSSAVSSLASPLVSGSASHETSTTPGATPSGLMPETVRSASAAARMTFIQAQRERLRLVLSALEREEQAAQQQLQNEESGDTLSPGKRSRSVGDFEKVDIVEGEEEQGVRRRNTAAGTSSAGEGSGGWLWGWGKGKSSGVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9J9</accession>
    <name>G0S9J9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0046150</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family. PPIase D subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694995.1">
        <property type="nucleotide sequence ID" value="XM_006694932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9J9"/>
    <dbReference type="SMR" id="G0S9J9"/>
    <dbReference type="STRING" id="759272.G0S9J9"/>
    <dbReference type="GeneID" id="18258653"/>
    <dbReference type="KEGG" id="cthr:CTHT_0046150"/>
    <dbReference type="eggNOG" id="KOG0546">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_37_0_1"/>
    <dbReference type="OMA" id="EMEQNCN"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000029">
        <property type="entry name" value="peptidyl-prolyl cis-trans isomerase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000009">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0697">Rotamase</keyword>
    <keyword evidence="8 11" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="12">
        <location>
            <begin position="21"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="11">
        <location>
            <begin position="318"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS20110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="382" mass="42303" checksum="E21A4DA5E7813FE0" modified="2011-10-19" version="1">MTAEENKPVSTEEKKNRSRCFFDITIGGKPVGRIIFELYNDIVPKTAENFRALCTGEKGIGKSGKPLHYKGCIFHRVIKQFMIQGGDFTAGNGTGGESIYGAKFEDENFELKHDRPFLLSMANAGPGTNGSQFFITTVATPHLDGKHVVFGEVISGKSVVRQIENLQTQADKPIKDAVIADCGELDPSEALDAATKKADKYGDEYEDFPEDQHPGDEAMPAQEVLKIASACKEYGNKAFKDGDYSVALDKYQKGIRYLNEEPDFDNEPAEAKQQYDQLRVTLNSNAALMNIKLGDWKEAVKCADNALLVEGISDKDKAKVLYRRGFAQVRLKDEDEALKNLEEAIKLVPEDPAVKAELAAVKKAAAERRAKEKAAYKKFFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9P7</accession>
    <name>G0S9P7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0046650</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695043.1">
        <property type="nucleotide sequence ID" value="XM_006694980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9P7"/>
    <dbReference type="GeneID" id="18258703"/>
    <dbReference type="KEGG" id="cthr:CTHT_0046650"/>
    <dbReference type="HOGENOM" id="CLU_1610563_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="165" mass="18304" checksum="5A385CE48CE99542" modified="2011-10-19" version="1">MAANLIIGFLKLLYGNLRLKYEVWQTQKEILEAMREADPFLDVERLTCVSLEEQQAHVSGARAAYDQTAFEIRGVREAWSQLPADERRDIPLPEAPPCPHSTPPPTSPPTSSSRNQNPGCRPPPPSLSDPAVGTVARPPRAPSLLVPRPAPRRPPRLRPRRPANT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9Q6</accession>
    <name>G0S9Q6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative FAD binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0046740</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695052.1">
        <property type="nucleotide sequence ID" value="XM_006694989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9Q6"/>
    <dbReference type="STRING" id="759272.G0S9Q6"/>
    <dbReference type="GeneID" id="18258712"/>
    <dbReference type="KEGG" id="cthr:CTHT_0046740"/>
    <dbReference type="eggNOG" id="ENOG502SJ3M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_0_1_1"/>
    <dbReference type="OMA" id="TSIFMFE"/>
    <dbReference type="OrthoDB" id="9996127at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF9">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409394" evidence="6">
        <location>
            <begin position="21"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="81"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS20167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="514" mass="57142" checksum="6A33E441324DC1F5" modified="2011-10-19" version="1">MRWQSMLLAAATAFSGLVAGMPILDPEGFTPYARGLEELTLFSPGCSIPDFWRFITRLSHNAEIYFQGQNKFNTYSIRWSNVGTPKVNITILPATENDVVEIVRLANGCNIPFLAYNSAHGSITTLKNMSWGILINLRKLSGVTIHAANETATILGGTNSKYMIQQLWDAGYQAVTGTCECVNYMGPALGGGHGWLQGHYGLIADQFRSLNVVLANGTKITVGPDHELFWAMNGAGHNFGIVTSANIKIYPKIHTTYAIEILTFTGDKAKDLYEAAITTFANQPVEVIQWSYWMNIPQLDPTGPIIEFYIIQEGVTAVDSQWTAAFYALNPIAANPQTGSYLDLSTWLSINMDGPPCQKTGMANPRFPLYLESFNATAMEEVYEAFKAGTNSSGPFYNSLFMFEGYSMQGVQAKNASNAAFAWRNDNLLVAPLIQYQPGNPALDEAAKQFGNELRQILHRGSGRTEMHTYVNYAYGDETPEEWYGHESWRLTKLRQLKTKYDPNNRFSFYGPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9S9</accession>
    <name>G0S9S9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">U4/U6 snRNA-associated-splicing factor PRP24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0047040</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a recycling factor of the spliceosome, a machinery that forms on each precursor-messenger RNA (pre-mRNA) and catalyzes the removal of introns. Chaperones the re-annealing of U4 and U6 snRNAs (small nuclear RNAs) released from previous rounds of splicing, an initial step in reforming the U4/U6-U5 tri-snRNP (small nuclear ribonucleoprotein) that can reassemble into another spliceosome complex; this step involves binding U6 and facilitating the unwinding of the U6 internal stem loop, followed by base-pairing of U6 to U4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695075.1">
        <property type="nucleotide sequence ID" value="XM_006695012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9S9"/>
    <dbReference type="STRING" id="759272.G0S9S9"/>
    <dbReference type="GeneID" id="18258742"/>
    <dbReference type="KEGG" id="cthr:CTHT_0047040"/>
    <dbReference type="eggNOG" id="KOG0128">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003925_2_0_1"/>
    <dbReference type="OMA" id="LWARYIL"/>
    <dbReference type="OrthoDB" id="360390at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12296">
        <property type="entry name" value="RRM1_Prp24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12297">
        <property type="entry name" value="RRM2_Prp24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000365">
        <property type="entry name" value="U4/U6 snRNA-associated-splicing factor PRP24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034397">
        <property type="entry name" value="Prp24_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034398">
        <property type="entry name" value="Prp24_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031766">
        <property type="entry name" value="RRM_occluded"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16842">
        <property type="entry name" value="RRM_occluded"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="601"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="675"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="767"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="877"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="559"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="966"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1021"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="584"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1030"/>
            <end position="1039"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00093627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS20190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1069" mass="120463" checksum="C84E5F7107169D7C" modified="2011-10-19" version="1">MTNPVGEDNWLEHVERQIRQATDLEGRVRVIESFQRATLAEPGSLKLWIAYCEYFWSLYVDCNQRGNEIGWPQDELAIGRETFTFDAALNLWQEGYEAVQYRLSDSHELWNRWVSHEMELLRRTTTEAGVRRITQLFKNRLLVPHATWNETSQMFSTFLSEYNRHAWETEMEQITRNAQGAKKLYEQRDPWEMKLAAATRSRDAAAMRSVMTEYLDWEIKQAKTRKDRDEAIACFQICLGLFSRALTGVLSSDENTWMNYIVFVSTTHTDIKEGRSPVPGHMVPDMLDALSRSVKHVPWCGALWARYILAAEESGLSFSDIEQIKHSATDNGQLDRDGMMGVLEMYAAWCGYLKRTAMVPDASEEAVDVAEVGLLSALEDVKHWGTRKYDNYQGDPQYRLEKILIQFLTEKKDDIDGARAVWEDLAKNPLHAGKYDFWLNWYFWEMMVFTTLRNRTPSPTPTNACQALRVPTFATEVLTRALKVRGLNWPDRVMEIYLQHCNDYETAETLREAQDTVLKTRKALAKRREREAAQAAQVAQVQWAAQTVNSADYHMVDVSETVGSPGSKRKREETPEDGTGSKRAKNENNDEERLKRDRENTSVFVLDLPAEVTQTKLKQFFREYGHINNIDIQKRDGEVVALVEFKTSDEAKSALLRDGKYLGDRVVRVQPATDCTLFVTNYPPDADERYIRHLFKDCGEIHSIRFPSLKYNTKRRFCYVTFRNREAATAATKLDGKPLSDGKYKLVAKFSDPLAKQQRHGAQAEERELHVINLPRGTSEEDISGLFSKAGRVVSVRVPRNMAGQSHGTAFVVMETKEQAQEAIRLCDKLIFGNHPIKVELSRPTTTKTTAVARVMDGTPEPQEGQGMPTPAEIAARTIAVLGIPDTMTDARVRAALTSATNAPIVKLVLHPVHGGAIVEFADAAAAGKAALSIDGMEIEPGKKVRTGTTQELFRNKAEKRVDRIDKPHSQPQSHAHPLQQQASQDKKSAAELMPPPTLLRRPGSGPKLKRGLGFVGAISAKKSAPATINGEQGQTGSKSNEDFRKFFLASRTAANAEGEAKNGNSGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9X9</accession>
    <name>G0S9X9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial phosphate carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0047560</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695125.1">
        <property type="nucleotide sequence ID" value="XM_006695062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9X9"/>
    <dbReference type="STRING" id="759272.G0S9X9"/>
    <dbReference type="GeneID" id="18258794"/>
    <dbReference type="KEGG" id="cthr:CTHT_0047560"/>
    <dbReference type="eggNOG" id="ENOG502SA1K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_177926_0_0_1"/>
    <dbReference type="OMA" id="MPLIARR"/>
    <dbReference type="OrthoDB" id="9992270at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40135">
        <property type="entry name" value="MITOCHONDRIAL PHOSPHATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40135:SF1">
        <property type="entry name" value="MITOCHONDRIAL PHOSPHATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="66" mass="7276" checksum="C659D4142FDE26E6" modified="2011-10-19" version="1">MFLTRAISVTNFVVATSALTFQVCVLYPWHKQLDDDFEALKKEHLRVLGAIKAIGEGAAGQKEKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9Y1</accession>
    <name>G0S9Y1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0047580</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695127.1">
        <property type="nucleotide sequence ID" value="XM_006695064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9Y1"/>
    <dbReference type="SMR" id="G0S9Y1"/>
    <dbReference type="GeneID" id="18258796"/>
    <dbReference type="KEGG" id="cthr:CTHT_0047580"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="OMA" id="WFQFYGR"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF29">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS20242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="493" mass="55735" checksum="99D21CFFEDB69BED" modified="2011-10-19" version="1">MGIELTSGFDSQMINALQIVPAWKNYFNNPKGALKGIIAAAYSLGAILSLPLIPIVNDKFGRRWSIFGGSVIMVIGAIIQGFSTHVGMYIIARMILGFGIPTCIVSGSSLIGELAYPKERPVLTSLFNVAYFIGQIIAAAICFRTNNITTDWAWRIPSLLQVCPSLLQICFVFLLPESPRWLISKDRLQEAQDILTKYHGEGDRGLEFVAAEFAQMQTTIRLEMEASKRSWMDIVKTSGMRRRLLITCMLGLFTQWSGNTLISYYLVDLLEMIGYKDSTYTQKINVSIACWSLFCGVTVSLLVTRIRRRVMYLTCTISLLLCYIAWTISTERAQTAQDSGHPNRAANIATLFFIYAYSPCYNIGYNALTYTYMVEVWPYAERSRGISIFQLFGRLAGFFTTFVNPIGLDKAGWRYLISYCCWLAFEVCFVYFMFPETFGRTLEELAFIFEDKKLADEAVAAVEKIVQQREEHLEQGVMQKQDVSKAAEKTLYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G0SA80</accession>
    <name>G0SA80_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0041310</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694537.1">
        <property type="nucleotide sequence ID" value="XM_006694474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SA80"/>
    <dbReference type="STRING" id="759272.G0SA80"/>
    <dbReference type="GeneID" id="18258169"/>
    <dbReference type="KEGG" id="cthr:CTHT_0041310"/>
    <dbReference type="eggNOG" id="ENOG502SZQW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1669187_0_0_1"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42090:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="158" mass="17389" checksum="209289BD04F91D50" modified="2011-10-19" version="1">MSLTRTLRPLIPSWALLHPRILPPFQPCRALQTAALQYPYKDSQDRESLKPRPSMEESQSASADEIAEKQVSWDGNVTDPDLERSAAALESGGNPGYCNPLDLSAADREWGGTMTSEDAADKSDKKIRSRHEKGKKHGKVAPLPDKKASIKGALPKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0SA86</accession>
    <name>G0SA86_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0041370</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FMP52 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694543.1">
        <property type="nucleotide sequence ID" value="XM_006694480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SA86"/>
    <dbReference type="STRING" id="759272.G0SA86"/>
    <dbReference type="GeneID" id="18258175"/>
    <dbReference type="KEGG" id="cthr:CTHT_0041370"/>
    <dbReference type="eggNOG" id="KOG4039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071330_3_0_1"/>
    <dbReference type="OMA" id="CIENAKA"/>
    <dbReference type="OrthoDB" id="430436at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051170">
        <property type="term" value="P:import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000366">
        <property type="entry name" value="Protein FMP52, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097:SF7">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="7">
        <location>
            <begin position="5"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS19658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="235" mass="25000" checksum="8ECE563A467E167E" modified="2011-10-19" version="1">MASTLVLGCTGLTGSFILTNLLSNPSTGTVHTISRRAPKAPADPKLHAIVDTDTTTWATTHLPSLSPPPTTVISALGTTRAAAGGITNQWKIDHDLNVELARAAKAAGVKNFVFVSSAGTRGVLANRVPYSQMKQGVEDTVKELDFETAIILRPGAILGKREESRPAEAVFQGLVRGIGKIVGVWAQDKIGQEAEVIARAAVHAARIAEEGKAPAKWWVLEQADIVRLGRDEWKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAD1</accession>
    <name>G0SAD1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative ADP-ribosylation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0041850</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694588.1">
        <property type="nucleotide sequence ID" value="XM_006694525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAD1"/>
    <dbReference type="STRING" id="759272.G0SAD1"/>
    <dbReference type="GeneID" id="18258223"/>
    <dbReference type="KEGG" id="cthr:CTHT_0041850"/>
    <dbReference type="eggNOG" id="KOG0071">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040729_9_3_1"/>
    <dbReference type="OMA" id="GGQISKM"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04149">
        <property type="entry name" value="Arf6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000412">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041838">
        <property type="entry name" value="Arf6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="3 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="26"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="128"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS19703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="188" mass="21187" checksum="7F698061CC1752A4" modified="2011-10-19" version="1">MGASMSISSLFGKLFGSKEVRILMLGLDAAGKTTILYKLKLNQTMTTIPTVGFNVENFTYKNIKFNMWDVGGQDKIRPLWRHYYSGTQALVFVVDSADHARIDEAKTELHRILNDREMSECLLLVFANKQDIAGAMDPQKITEKLELHKLGDRPWYVQPAIAIDGEGLTEGFSWLSDNIKKLPKYGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAX5</accession>
    <name>G0SAX5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Threonine dehydratase</fullName>
            <ecNumber evidence="12">4.3.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Threonine deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0048140</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22108"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.3.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from L-threonine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="12"/>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695177.1">
        <property type="nucleotide sequence ID" value="XM_006695114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAX5"/>
    <dbReference type="STRING" id="759272.G0SAX5"/>
    <dbReference type="GeneID" id="18258852"/>
    <dbReference type="KEGG" id="cthr:CTHT_0048140"/>
    <dbReference type="eggNOG" id="KOG1250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021152_6_0_1"/>
    <dbReference type="OMA" id="TRFEYTK"/>
    <dbReference type="OrthoDB" id="4418812at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04906">
        <property type="entry name" value="ACT_ThrD-I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04907">
        <property type="entry name" value="ACT_ThrD-I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1020.10:FF:000001">
        <property type="entry name" value="L-threonine dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000008">
        <property type="entry name" value="L-threonine dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1020.10">
        <property type="entry name" value="Biosynthetic Threonine Deaminase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001721">
        <property type="entry name" value="TD_ACT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038110">
        <property type="entry name" value="TD_ACT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005787">
        <property type="entry name" value="Thr_deHydtase_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01124">
        <property type="entry name" value="ilvA_2Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006674">
        <property type="entry name" value="PRK09224.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF11">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00585">
        <property type="entry name" value="Thr_dehydrat_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51672">
        <property type="entry name" value="ACT_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7 12" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ACT-like" evidence="14">
        <location>
            <begin position="403"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="ACT-like" evidence="14">
        <location>
            <begin position="502"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS19355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="583" mass="64137" checksum="CC55CA9DD1A279EF" modified="2011-10-19" version="1">MNTPETFETSRANGASQSQTPSQSNTPLLRTPSLSSLALTEYSARPSPPSEDRIAKMKKIVPEEFLLPNGNPDYLRLIITSYPRVREVCHETPLTHAVNLSNRLERKVLLKREDEQPVFSFKLRGAYNKMAHLDPKQSWRGVICCSAGNHAQGVAYSARRLKIPATIVMPKGTPSIKHLNVARMGGHVVLHGADFDEAKEECARREKQDGLINIPPFDDPYVIAGQGTIGMEILSQTNLQKLEAIFCCVGGGGLIAGVGVYVKRIAPHVKIIGVETYDADAMAQSLEKGERVVLKDVGLFADGAAVKTVGEETFRICQEVVDEMVRVTTDEACAAIKDMFEDTRSIIEPAGALAIAGLKKWAAANPCSDPTRTLVAITSGANMNFDRLGFVGARATIGEGREALLAAKIPEKPGAFAELINCVMPHSVTEFSYRYFDDTQANVLVGISLTAPGSQRAHELQTIINRIKESGTMDVTDLSGDELAKSHIRYMVGGRSNVPNERLYMFRFPERPGALERFLRTLRPKYNISLFQYRNYGGDIGQVLTGILCPNEEVAELETFLKEIGYPWEDCTDSPVFKTFLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0SB09</accession>
    <name>G0SB09_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UROS (Uroporphyrinogen-III cosynthetase)-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0048480</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695211.1">
        <property type="nucleotide sequence ID" value="XM_006695148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SB09"/>
    <dbReference type="STRING" id="759272.G0SB09"/>
    <dbReference type="GeneID" id="18258886"/>
    <dbReference type="KEGG" id="cthr:CTHT_0048480"/>
    <dbReference type="eggNOG" id="KOG4132">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051874_0_0_1"/>
    <dbReference type="OMA" id="IHGADTG"/>
    <dbReference type="OrthoDB" id="5595751at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10090:FF:000011">
        <property type="entry name" value="Uroporphyrinogen-III synthase (UroS), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390">
        <property type="entry name" value="UROPORPHYRINOGEN III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390:SF0">
        <property type="entry name" value="UROPORPHYRINOGEN-III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="HemD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrapyrrole biosynthesis uroporphyrinogen III synthase" evidence="1">
        <location>
            <begin position="35"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="322" mass="35259" checksum="41909A29ABAEB67A" modified="2011-10-19" version="1">MPTSIPVFLLKTRSSPTDAYEDLFASSTSPNGEPFSPSFVPVLEHRFDDTGLAQVRSLLKLRAIGNCQECAYGGLIFTSQRAVEAFALLVAEKKTAGVGGDNGNNPQNEQVSWPDLEDIPVYSVGPATTRALRAIPLNPPLQVIGEHTGAADELAPFIIEDYSKRYADREKKPPLLFLVGEKHRDVIPRVLREQAGWRVDEVVVYGTAELASFREDFAQRLGETVNFPVRWVVVFSPSGCEAMLAALGFLDEKTGRAKPKSNLDEKTTTSTFIATIGKTTKAHLVTKFGYEPEVCAEQPTPKAILEGIMRFMAALPQSSSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBF1</accession>
    <name>G0SBF1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Beta-xylanase</fullName>
            <ecNumber evidence="6">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0050050</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695353.1">
        <property type="nucleotide sequence ID" value="XM_006695290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBF1"/>
    <dbReference type="GeneID" id="18259043"/>
    <dbReference type="KEGG" id="cthr:CTHT_0050050"/>
    <dbReference type="eggNOG" id="ENOG502QR4K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_435448_0_0_1"/>
    <dbReference type="OrthoDB" id="3055998at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12108">
        <property type="entry name" value="Hr-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35585">
        <property type="entry name" value="HHE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35585:SF1">
        <property type="entry name" value="HHE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409459" description="Beta-xylanase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="9">
        <location>
            <begin position="43"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="361"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS19531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="628" mass="69342" checksum="3DAE4C9AB19D23E8" modified="2011-10-19" version="1">MQTKALLAALLATPAAVNAQLHNLAVAAGLEYFGTCLGESAYNSDSTYRRIISDKNEFGQVVPENGQKWDATEPSRGNFNYNSGDISANAARANGQLLRCHTLVWHSQLPGWVSSGYWTRSTLQSVIETHINNVMGHYKGQCYHWDVVNEAVDDNGNWRDSVFYRTFGTDYFAIAFRAARAADPSAKLYYNDYNLEYNGAKTDRALELVRIIKNAGAPIDGVGFQGHLIVGSTPSRSNLATVLRRFTALGVEVAYTEIDIRHSSLPASSSALVTQGNDYANVVGSCLDVEGCVGITVWGFTDKYSWVPSTFNGAGDALIYDSNFNKKPAWTSVSSVLAAKATGNPLPVTSTTFATVTTTSVRPTTTSAAPTTTAAPAQPEQTRWGQCGGIGWTGPTSACFSIDLTMSRRLLAKTALQPFRAFLAPAVRYQTTETFKGTARIPTAVATRVSDSIKRDHRELEQYYNKIKSSSSDDEKTRWQNQFVWELARHSVAEELVVYPAFERHIPSTGHDMAEKDRSEHRIVKEKLHDFQSMSPSDSNFLPTIDSLWQVLSQHIREEERDDLPALEEHVDAGTSDSLARSFDRTKHFVPTRSHPSAPDRPPYETAAGMLATPMDKLMDMFRKFPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBP8</accession>
    <name>G0SBP8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit M</fullName>
            <shortName evidence="5">eIF3m</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0054340</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit M family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695769.1">
        <property type="nucleotide sequence ID" value="XM_006695706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBP8"/>
    <dbReference type="STRING" id="759272.G0SBP8"/>
    <dbReference type="GeneID" id="18259472"/>
    <dbReference type="KEGG" id="cthr:CTHT_0054340"/>
    <dbReference type="eggNOG" id="KOG2753">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035254_0_0_1"/>
    <dbReference type="OMA" id="FNDEHKG"/>
    <dbReference type="OrthoDB" id="10267031at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03012">
        <property type="entry name" value="eIF3m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027528">
        <property type="entry name" value="eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040750">
        <property type="entry name" value="eIF3m_C_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF2">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18005">
        <property type="entry name" value="eIF3m_C_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="7">
        <location>
            <begin position="338"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="548"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="548"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS18824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="587" mass="66400" checksum="F7DCCC6FC34B0405" modified="2011-10-19" version="1">MATIAGQGNSAGIAGAEKATGAEGNQATKNSNQSPRVRRPLPLPEPLRNPRQLHYSVPYELEDAISPPALPKRNKSSPPHRQPEPVRYLTDCLSPVPEVLRLPDPISDLSSSEPSSAHSGYWDYYRNSRTAALLEGVTAYLNFFGPKKPRYYCPTDEEIMATPQLLFVDGTFAELAQELADFIQIGDQVRPLLAQEQNDEALEAIVKASHALNSAPEKDFTGAYNLLIHLVLQSDDPKKYLPTVCGNLLKPITSSPAHGFTLAANALSTIFNLLQPSNPLRYNVFLQIVRFIRQHSQFEVLKPRLKNLDGWFAAWKSDEEDKRKLYVEVSDTAAESGDEDEAYHYLLKAIGTFDREDQDDLSSEEAQKLSLKAIRMALLSPTRFDFQDLRALPAVQALGDSQPIYSQLLDIFTEQDLEDYNDFNEEHKGWLEKEGLDHEKLQRKMRLLTFASLAASTPNREIPYAKIAERLQIPIEEIEHWTIDVIRAKLVEGRLSQQQKVFLVHRTTYRVFGEKQWRELGTRVDQWKSVVDRLLTVVRKAQADVEAQREREQQELEKKLANANISGGHGGRHKGGKQQQQRTDEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBU1</accession>
    <name>G0SBU1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Serine/threonine protein kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0054780</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695812.1">
        <property type="nucleotide sequence ID" value="XM_006695749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBU1"/>
    <dbReference type="STRING" id="759272.G0SBU1"/>
    <dbReference type="GeneID" id="18259516"/>
    <dbReference type="KEGG" id="cthr:CTHT_0054780"/>
    <dbReference type="eggNOG" id="KOG0598">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_37_1"/>
    <dbReference type="OMA" id="KGSIFAM"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000048">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000222">
        <property type="entry name" value="Serine/threonine-protein kinase psk1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="201"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="9">
        <location>
            <begin position="462"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="116"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="116"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS18867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="546" mass="60948" checksum="697F3A65EDCFAF5B" modified="2011-10-19" version="1">MVPPPPRAKNTVRGFHGTPVMSTDEDSDCFTQSRSSEKNALKLSKKRRQHVFQDVVNVVNASCSPVFKPQVANGGSIGAISQLRMRMETLSLQTPTTSTATSSRCSSLTQSECLASPASSNTTISSGKRSTENLADSGYKSRSNSSTPASDDETASQGSPSYEIKLENDFVSRSEQPYNEAFRGTFEDASSSCRKMTAEDFEPLRCLGKGAYGTVLLVKQRSTGRLFAQKQLKKASLFVSNKLIEQTKTERQILESINSHPFVVKLYYAFQDHEKLYLILEYGQGGELFTHLKTEKLFTEQTAAFYMAEMIIALTHLHDELGVVYRDLKPENCLLDAEGHLLLTDFGLSKVAVDSDGCDSILGTIEYMAPEVILGKKYGKAVDWWSLGALGYDLMTGSPPFRGPNKARIEHNIVHQKLSLPYFLSPDAKDLLTRLLRKDPTKRLGYNMPRDLETIKKHRFFRRIDWDKLSRRELTPPIQPVITDPELAENFDPEFTEMPLSPVVSRRGDFEDATHYGSPADAHTANDPFRGFSFVAPSTLLETFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBV7</accession>
    <name>G0SBV7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative high-affinity glucose transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0054950</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695828.1">
        <property type="nucleotide sequence ID" value="XM_006695765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBV7"/>
    <dbReference type="GeneID" id="18259533"/>
    <dbReference type="KEGG" id="cthr:CTHT_0054950"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_1_1"/>
    <dbReference type="OMA" id="RRTFTGC"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF40">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="379"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="24"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="519"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="532"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="572"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS18883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="592" mass="64338" checksum="34E72EADC9DBF2AA" modified="2011-10-19" version="1">MAVFAMGWQKPDNVAGSSAPAIMVGLFVASGGLLFGYDTGAINGILAMDAFKRDFTTGYVSEDGKLGMSPAQVALIVAMLSAGTAVGALLSAPMGDFWGRRTSLIVAIGIFCIGAILQVCASRIPLLVVGRTVAGLGVGIVSVLVPLYQSEMAPRWIRGTLVCAYQLSITMGLLAAAVVNILTYKLESAAAYRIPIGLQLTWAVVLALGLLILPETPRYLIKRGRKDDAALSLSRLRRLDITHPALIEELAEIEANHQYEMSLGPDTYKDIIFGEPHLGRRTLTGCGLQMLQQLTGVNFIMYYGTTFFNGAGVQNPHTISLIMQIINVVSTFPGLFVVESWGRRRLLIVGAIGMAISQILIAAFATAMGQDNQTAQNRILIAFVAVYIFFFAASWGPVVWVVTSEIYPLKVRAKSMSVSTFSNWLLNFGIAYGTPFMVDTTGVKEDGRVRTADLGSRVFFVWGTFCLLSIAFVWYMVYETSKMSLEQIDEMYERVNHAWNSRNFQPSWSFQQMRDLGYSDSGIPPDPQVELQQQQSNQNHSSSSLSSSSSRSSTSQSESGGSSAPTGITAPSLPNSQDNKFMSNLGHVDFSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G0SC61</accession>
    <name>G0SC61_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0056060</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695932.1">
        <property type="nucleotide sequence ID" value="XM_006695869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SC61"/>
    <dbReference type="GeneID" id="18259644"/>
    <dbReference type="KEGG" id="cthr:CTHT_0056060"/>
    <dbReference type="eggNOG" id="ENOG502SPC3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093250_0_0_1"/>
    <dbReference type="OMA" id="CTENPND"/>
    <dbReference type="OrthoDB" id="5426355at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="21944" checksum="A63E9EF0F6D42F11" modified="2011-10-19" version="1">METTLFPVAALPTCVTRCGVLYDVNGACVPPGATKADAATYNRCFCADPRLAAFSQGPLGICDSACTENPNDLSSIQGWYTSFCAQATKAATSTARPQGQDGGTWLDNHYQWVIFLVIMVVAIVGIWIGACVWRKRYLRKKDRQYALSNGFAHTTSSGRIVPNASAGSVHVPTAGFFDPAPISSAAVYEKPPKAKKWVFRERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCR4</accession>
    <name>G0SCR4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative cell division control protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0058150</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696135.1">
        <property type="nucleotide sequence ID" value="XM_006696072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCR4"/>
    <dbReference type="STRING" id="759272.G0SCR4"/>
    <dbReference type="GeneID" id="18259853"/>
    <dbReference type="KEGG" id="cthr:CTHT_0058150"/>
    <dbReference type="eggNOG" id="KOG0305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014831_6_0_1"/>
    <dbReference type="OMA" id="PVKSHHG"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000098">
        <property type="entry name" value="WD repeat-containing protein slp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF8">
        <property type="entry name" value="FI02843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="9">
        <location>
            <begin position="278"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="323"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="406"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="537"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="149"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS19190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="598" mass="64865" checksum="46CFBC1732D067D1" modified="2011-10-19" version="1">MATATVSTPLKPHAGLFSSRTAGGRMPLTPSPSRRTKSINLNDSPCTPEKQADSPRVSSKSVYGGNLTAHLAKASSKNQHRDSPKSNIARTVSSPRKALELGVSDFTLTGAGSHTKTPSNTKTKKTATIRQKSSKTTLTYHADRFIPNRGASSAIANPGSGKLDIKDKKRSKKSRNEASSVLTSATDDALAALEGLNIEDEEPESYSRPSPNTVAYQDSLANACGVNLNTRILQFKPAPPESSKPIDLRKQYNRPLKPANASSAQFRRRIATAPERVLDAPGLIDDYYLNLLDWSSCNQVAIGLERNVYVWSADEGTVNCLLETSPDTYVSSVKWSQDGAYVSVGLGTGEVQIWDVAEGVKIRSMFGHDTRVGVMGWNKHILSTGSRSGLVFNHDVRIAEHKVAELVQHTSEVCGLEWRSDGAQLATGGNDNLVCIWDARSLAVPKFTKTNHKAAVKALAWCPWNMSLLATGGGSYDRHIHFWNTTSGARVNSIDTGSQVTSLRWSTHYREIVSTSGFPDNSLSIWSYPTLVRNVEIPAHESRVLHSCLSPDGQMLATAAADESLKFWKIFEKKPGTPSITTTGSSAKAELAKSMTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0SD11</accession>
    <name>G0SD11_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative nicotinamide mononucleotide transmembrane transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0050380</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695386.1">
        <property type="nucleotide sequence ID" value="XM_006695323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SD11"/>
    <dbReference type="GeneID" id="18259076"/>
    <dbReference type="KEGG" id="cthr:CTHT_0050380"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="OMA" id="TWRTTFY"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF57">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="441"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="57"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS18441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="505" mass="56609" checksum="4D5DC1B5DCAE328A" modified="2011-10-19" version="1">MGNPKHEVSAPDVTTESDSVANEKSVFKGGVDDVHVESAGWDEASTKRLIRKIDYTLIPFLAFLYLLSFLDRSNIGNARLDTLEKDLNLKTDKYQYNDALAVFFPFYVAAEIPSNMAMKRFRPSIWIPSIMVVWSICTTLMGIVENYAGLMACRCALGLAEGGLFPGITYYITMWYKRHECGLRMAIFFSAATAAGAFGGLLARGIMEMRGVGGLSGWQWIFILEGLLTFVVAVAAYIIMQDYPATAKFLTPEEREEVQARLKRDRSSLADEFDMKYFWQALKDWKIYCHMFITIFVYTALYSYSLFLPTIINELGISKTPEQSQLLTVPPYFVACLFCVAAGWYADKIGQRGIFMIGFMLIAIAGLLMLICTTNPAVRYIGCFLLATGVYPNVPMGVAWNGNNIGGSLKRGVGIAMHVGFGNLGGVVSSYLFLAKHKPRYFSGFGVLLAFQVAAVVLSVIMHIYLRRENARRDREYKPPSEYTEAEKLAEREKGDYASFFRYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDF3</accession>
    <name>G0SDF3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Reductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0051580</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695499.1">
        <property type="nucleotide sequence ID" value="XM_006695436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDF3"/>
    <dbReference type="STRING" id="759272.G0SDF3"/>
    <dbReference type="GeneID" id="18259196"/>
    <dbReference type="KEGG" id="cthr:CTHT_0051580"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="OMA" id="NSLACGP"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF17">
        <property type="entry name" value="RHAMNOLIPIDS BIOSYNTHESIS 3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS18554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="272" mass="28705" checksum="9386581C4A2D3FD7" modified="2011-10-19" version="1">MDLESLFSVKDKVVLVTGGAKGIGRMISEAFVRNGARVYIASRDGKACDAAAAELNALPGKPSSGQAIAIPANLASLDDCKRLAEELKKRESKLHVLVNNSGATWGEEYEKYPDSAWTKLLTLNLHRVFTLTQLLTPLLEAAAVRSADGVIVDPARLIHIGSIDGIRVPKLPTFAYSSSKAGLHHLSRHLAVELGPRGITSNTLACGPFPSKMMAHTLKTFGEEIRAANPLGRIGLPSDVGGACLFLASKAGGFVNGATIRVDGGVSLQSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDJ7</accession>
    <name>G0SDJ7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pentatricopeptide repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0052030</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695543.1">
        <property type="nucleotide sequence ID" value="XM_006695480.1"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="2" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="415"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="86"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="929"/>
            <end position="1025"/>
        </location>
    </feature>
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        <location>
            <begin position="798"/>
            <end position="828"/>
        </location>
    </feature>
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        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
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        <location>
            <begin position="958"/>
            <end position="1015"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS18598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1042" mass="120814" checksum="81FDDF12E482E8D3" modified="2011-10-19" version="1">MLERAGLVCRRCAARAGQPQWPFLRPLGGATGRAARAIGASQRSSNTPDTPKHASTVASPSPSHCADHIASSFHAQLEQPFHPATLRNFQPPQAAPPNTNPPKPTYEQRESAPPYISYERRRIRRRRPFTKDYYELARLNGTTMRHEKREYRRWEHRYLPCFNRIKTHGPQPYMPLESAPDNFGVPGSSPLLKEFLAQGDVASMHVWWHMKPVEERKRLWRGIFISTLGYAPHRAIDVLEVVAQYGVVPRYAVFDMFNYIIHWTLSLPLSCRPVYHARLAPLMLRLTREYRQIPWLQWTIYRVVSVSKAPMIAELYKEFLQRRKHLHSNTLLHIANRLAKDVHYKLLATDILEHLVCDRKLKPHYATILALNTAILKFPKPHPGSLEPKHFPPNKIPQLQAVLYERLAKLGLQPNLIHYTAMITGLCWAKKMSTAWRVYDEMCNQGIVPDVNVYGVLLHGAKLTSDVESVIRVFDEAPADILKSPYVWNEVLHIIHRIASREAIERTIRETRAVLDHEHIGPFAWKRSTWVPALHPGFHVMLELYSRFFKPEPLCHLLGFSSPSDLYNAVQQDDRHWRWKETLAPVLDRLSQAPVPKASVDPQIYTLGIMLLTYLRSVPDAQPIMSFYSHFQKLVNLRDPIAVKMLRKGSLVYDSVIYSLTQFDNTLRLAQNIIRDMLNGAAASYPHKSEGYDIPTNYDHNPDFTVDPPPEPIRLPKPGVYTWSILIAAANRKGIRHSGAIWREMRRHGIHPTKATWNVLLWAFAREQKPLSVAKTLVAMEQAGIEGDGHTMRAFSKLADKERALRYYEKLAERMRQEQKEQEDFRLQPWQQMLLDLQDRVRRHDRDRDERMMTSEERMARIRQQQLETQVPLLMEQLDSPRPTRPLQVYNRNHGEKQARASWDAIVAAVQEADGVMFNLEGGNQPMVAQTRTQQQEQQQEQSGPSAVPPTDYDSFFQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQLDELPLQPLDPVLPLPGRRPKRKLDSELTDAFSELLLDSENEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDK9</accession>
    <name>G0SDK9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Developmental regulatory protein wetA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0052150</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18610.1"/>
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        <property type="nucleotide sequence ID" value="XM_006695492.1"/>
    </dbReference>
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    <dbReference type="STRING" id="759272.G0SDK9"/>
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    <dbReference type="eggNOG" id="ENOG502S8IT">
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    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
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            <end position="159"/>
        </location>
    </feature>
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        <location>
            <begin position="534"/>
            <end position="581"/>
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        </location>
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        <location>
            <begin position="683"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
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        <location>
            <begin position="564"/>
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        </location>
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        <location>
            <begin position="683"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="699"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="753"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="815" mass="85247" checksum="A76A87AE431DFA67" modified="2011-10-19" version="1">MANVEGVFNPSTNGLSKPTTNREKGSSCWPEGPSSASEVGYQADFYDQYLDFDDCSDVESLLGAAGERLERSGGGEGRGGGALGLFGVSPAVSSSPQLSHSQANGLTLTGTAALAASSAPASQGESVHGNSSASSSSQLRKQHPSTLHRATSDTTDYPHMPAGIAATAATAAPKIAVDDVPCPSGVFDTPTGTGSISDSELLNLEGLTMRSPRLNITHHQLPVSASEPASPLLSSTASPLKTRFGALHIKIKEKAAATLQTKSKQSESEQVAVSVSVSQATLTNPTLSMAQIEGVKPRLRTESLDFSNQRLQSASLIGIETTQQPPSNLPPVISPSSEEAILNSLLDNDPFLQNPPLPDVSMSSVHLTNGSMTQTPMQTPLPDPIQSWDLPLTLPDDKALWTTAAEAGSMPYFDNLPIAADPTTTVGTAAWCDPTTSFPDLDVAMDTDSLPITTSSLACQTSTNAQDTALSVSLFLSQPQQPQTTFDYPSPPITTDETIPTFSTTNSMLHMPQPHSILPAAALRAGAAHNWLSHRPKPKAPSSGARHHHHFYNPLSMSLRKTRSVPAPSGSGSHSPKGHFRTLSKTGAFFMPGGSAVHRRSSSLQGLTLGGSRQGLSSSLPAVGESPLLTGAGPGAITKRKSWTGRRAGSSASLHCQYHAHALAAAIDAVLSPLPSSALPLSTPITGSSSSPSKRRLTSHLSSPNNPPTSSTSGGKKPAPTPTDGFVNYTPQDRNLLMTGVAPSGSSKTKARREREAAERQREFRDKLTKMVQAAGGDVSKLGLEKLGIELGLGPIEVGEGKERRRERVEGEGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDM2</accession>
    <name>G0SDM2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Ubiquitin-like modifier-activating enzyme ATG7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Autophagy-related protein 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0052280</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the ATG7 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695568.1">
        <property type="nucleotide sequence ID" value="XM_006695505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDM2"/>
    <dbReference type="STRING" id="759272.G0SDM2"/>
    <dbReference type="GeneID" id="18259266"/>
    <dbReference type="KEGG" id="cthr:CTHT_0052280"/>
    <dbReference type="eggNOG" id="KOG2337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012998_2_1_1"/>
    <dbReference type="OMA" id="RQIWDAI"/>
    <dbReference type="OrthoDB" id="338614at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019778">
        <property type="term" value="F:Atg12 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019779">
        <property type="term" value="F:Atg8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01486">
        <property type="entry name" value="Apg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.100:FF:000003">
        <property type="entry name" value="Autophagy ubiquitin-activating enzyme ApgG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.70:FF:000001">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme atg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000243">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.100">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.70">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006285">
        <property type="entry name" value="Atg7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032197">
        <property type="entry name" value="Atg7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042522">
        <property type="entry name" value="Atg7_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042523">
        <property type="entry name" value="Atg7_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01381">
        <property type="entry name" value="E1_like_apg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF3">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16420">
        <property type="entry name" value="ATG7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like modifier-activating enzyme Atg7 N-terminal" evidence="11">
        <location>
            <begin position="4"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="10">
        <location>
            <begin position="348"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="679"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="680"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606285-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS18623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="699" mass="78173" checksum="EABFA3323BF65A45" modified="2011-10-19" version="1">MSALKFVPFSSEIELPFYSALFSLKLDHDKLDDSARPVLGLYEPQPQADPESSTKMQIRGNALTSNDVPAGMCRAKGYIKNVNTIEEFRNIDKNAMITDLGRQIWEAIQDGTIYSVPSLLSSFAILSFADLKKYRFTYWFAFPALHSDPPWKRVGAIGHLDSKESTALVDAVMTWRYVVSNEAEHGFFLAKKVRDRDAAAKSFLDDYAADLGYRWEIASLREFENGFFNNTDEADRYVAFVDPSNYDESPSWPLRNLLVLIRQRYRLKKVNILCYRDTQAKRHEARSIILPLEMEGTVDQAAPQKMPNVTGWERDVNNKLRARVANLADHMNPTRLADQAVDLNLKLMKWRLAPNLNLDGIKNTKCLLLGAGTLGSYVSRNLMGWGVRTITFVDNGAVSFSNPVRQPLFNFQDCLQGGKPKALRAAEALKEIYPGVEAGGYVLSVPMLGHPILDEKKVKRDFELLHKLVDEHDAIFLLMDTRESRWLPTVMGKAANKIVMNAALGFDTYVVMRHGAEPEDGSQETLGCYFCNDVVVAANSVKDQTLDQQCTVTRPGVAAIASAMLVELLSSLLQHPKKHHAPAPVPAPGSTTTYARDPEDHPLGLIPHQIRGFLSTWQNIVIHGKSYPQCSACSKSIIDAYRKEGWEFVKRALNSRDYVAELSGLAEVQRQAEKVAAELQWDDEDDGSAEAEEGDGVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEM7</accession>
    <name>G0SEM7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0064300</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696735.1">
        <property type="nucleotide sequence ID" value="XM_006696672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEM7"/>
    <dbReference type="GeneID" id="18260468"/>
    <dbReference type="KEGG" id="cthr:CTHT_0064300"/>
    <dbReference type="eggNOG" id="ENOG502SPM8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139299_2_0_1"/>
    <dbReference type="OMA" id="EQTRWSC"/>
    <dbReference type="OrthoDB" id="5015991at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="54"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="110" mass="13493" checksum="FDCDDDA0ADF003FF" modified="2011-10-19" version="1">MCYYDQLVWRCGYWKWSVFREQCPRERRMGETCGLRLVMTAYFQEDICKLCDEINKKQRRIEKMSQDIARWKLEGNRRATIDRTTAEIKEIEMKLDRLRVQHEGRIKGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFP1</accession>
    <name>G0SFP1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA polymerase</fullName>
            <ecNumber evidence="14">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CTHT_0071560</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="14"/>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697424.1">
        <property type="nucleotide sequence ID" value="XM_006697361.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0SFP1"/>
    <dbReference type="GeneID" id="18261194"/>
    <dbReference type="KEGG" id="cthr:CTHT_0071560"/>
    <dbReference type="eggNOG" id="KOG0970">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001718_1_0_1"/>
    <dbReference type="OMA" id="MTKMNVG"/>
    <dbReference type="OrthoDB" id="6755010at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05776">
        <property type="entry name" value="DNA_polB_alpha_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05532">
        <property type="entry name" value="POLBc_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3200.20:FF:000002">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000036">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2820:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3200.20">
        <property type="entry name" value="DNA Polymerase alpha, zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024647">
        <property type="entry name" value="DNA_pol_a_cat_su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038256">
        <property type="entry name" value="Pol_alpha_znc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045846">
        <property type="entry name" value="POLBc_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015088">
        <property type="entry name" value="Znf_DNA-dir_DNA_pol_B_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861:SF1">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12254">
        <property type="entry name" value="DNA_pol_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08996">
        <property type="entry name" value="zf-DNA_Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0235">DNA replication</keyword>
    <keyword evidence="11 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 14" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase alpha catalytic subunit N-terminal" evidence="19">
        <location>
            <begin position="11"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="17">
        <location>
            <begin position="479"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="16">
        <location>
            <begin position="793"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger DNA-directed DNA polymerase family B alpha" evidence="18">
        <location>
            <begin position="1281"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="58"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="151"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="276"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="830"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="159"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF12254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGS17806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1495" mass="169102" checksum="3203524A0ABD2AC3" modified="2011-10-19" version="1">MSNANKRNKFAELRALRQAGKKVFDTYQVAEVEDLYEEVDENQYKKIVRARLNQDDFVVDDNGEGYVDDGREEWDHEEYYSDEDDEVSVRGKDRKNKKQREQEQAKRDASDRDITEYFTRGAAKPQKKPKPVKTEEDEKFLADLLGEVDANVPAPLPRIPKKRDRSAERRKVRALSPLPEARPPVAKRTKMLDGSASSPPAIHDAAMIEDDGFIPSVESEPAAAPMSDIVMEEPELEPLPSSPVSKVVQRRTQVKIEPDDDVDDLMEVAHAGAVTTTSVNLSGSRQARKIPKPEPHSVPASSSPVRPSEPEVDASAWNSINQKLNVVSSSPTEAKTFGKIHYTDAIEEDGSLHFYWTDYTELNGSLCLFGKVLNKKKNHYVSCFVKVDNILRKLYFLPRKYRMRNGVETDEPVEMMDVYNEVDALMTKLGVDMHKIKPRKKKYAFELPGIPSEAEYLKLMYPYTKPQIELGKTGETFSHVFGTNTALFEQFVLWRNIMGPCWLKIEDADFGALKNASHCRLEVLVSRPDSISPIGDSESTDAPPLTLMSVAIRTIFNARDNKQEILAISARIYEDVLLNDTTPADKLPCRTFTVIRPQGATFPIGFEKLAKERKKGLIKLMRQESDMLSFFLAQLDMVDPDVIIGHQLEGVDYSILLNRLYERKTHQWSRLGRLRRSAWPASIGKVGGNLFAERQIMAGRLLCDLANDAGKSVMYKCQSWSLTEMCSMYLSGDDNRRRDIDNDAALKTWATSKEGLMDYISHAETDTYFIAALALRTQILPLTKILTNLAGNSWARTLTGTRAERNEFILLHEFKKAGYILPDKIPAKGRARVDEENQDDDGGEGGKKKDKYKGGLVFEPEKGLYDKYVLVMDFNSLYPSIIQEYNICFTTVDRSNLSDDEDAVPAVPGKDRDQGILPRLLGKLVDRRREVKKLMKTPRATPEQLATWDIRQLALKLTANSMYGCLGYTKSRFYARPLAVLITYKGREILRSTKALAESMSLQVIYGDTDSVMINANVDNVLAAIEVGNKLKQEVNKLYKRLEIDIDNVFRRILLQAKKKYAAINMVEENGRWVEKMEVKGLDMRRREYCPLSREVSKRILDEILSGDDTEVSVQRVHKYLREISAKMREGAIPLNKYIILTQLGKAPKEYPNADSMPQVQVALREMARGKVMRRGDVVSYIITTNKNNTSGSDSLPPAKRAYTPQDVMKADSGLVPDVEWYIGKQIMPPVERLCANIVGTSATQLAENLGLDPRHYANNRSAAYNTADAARDLEIHPLESQIPDHIRFSNCARLTLRCRACKHLFPFEGLLPLPASDAQQQKEAAEEQNKIITPSGIHCPSCSALLPTLTLVAQVETAVRAQTARYYETWLTCDDASCGNRTRQMSVYGTRCLGPRGLARDCLGRMRFEMGEREMYNQLVYFAGLWDVDKARKKVTEEKSVSEEEKERVLALAEHNRERFGTVKGVVDKYLEKCGRQWVAMDTLFAKLGFMPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFS3</accession>
    <name>G0SFS3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0071930</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697456.1">
        <property type="nucleotide sequence ID" value="XM_006697393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFS3"/>
    <dbReference type="GeneID" id="18261231"/>
    <dbReference type="KEGG" id="cthr:CTHT_0071930"/>
    <dbReference type="HOGENOM" id="CLU_1434296_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="189" mass="21357" checksum="D2EB687E9CE91DCF" modified="2011-10-19" version="1">MFCGSVYILWWNIEVHKINVGGDTGPLGVLSVFCGTVVNAYIAVTAFLRKYNLSHIKFALLADFAVASCILGAYLHTFINKEPSWIKWSYIGWKWQRRWKAAEVMLLVPCSLLYAAVVMAFVGFRITRGKREDRRKALHRNNNGNNNDIPMTTIQSNEPEAEVDPEIIDDPPPPYAADPPPYSEAPRQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0SG83</accession>
    <name>G0SG83_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0065400</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696840.1">
        <property type="nucleotide sequence ID" value="XM_006696777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SG83"/>
    <dbReference type="STRING" id="759272.G0SG83"/>
    <dbReference type="GeneID" id="18260578"/>
    <dbReference type="KEGG" id="cthr:CTHT_0065400"/>
    <dbReference type="eggNOG" id="ENOG502S51C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004583_0_0_1"/>
    <dbReference type="OMA" id="ATWAFEA"/>
    <dbReference type="OrthoDB" id="5409589at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.20">
        <property type="entry name" value="Gas2-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003108">
        <property type="entry name" value="GAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036534">
        <property type="entry name" value="GAR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02187">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143575">
        <property type="entry name" value="GAS2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51460">
        <property type="entry name" value="GAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAR" evidence="5">
        <location>
            <begin position="588"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="341"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="544"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="666"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="846"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="383"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="468"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="688"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="711"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="760"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS17222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="890" mass="96373" checksum="3EBA3C09C698B16C" modified="2011-10-19" version="1">MNEIPPPRETVGHLAPPSDPSPPLRPRINDDLLANLTPRTVVDAFRTPTGSLKACIERASPAEQAFALRVAIASSNIAQWLEELSSWPWPSSGGSAGFEVPAAKRRKLSPSGTGTSDAEEYTGSLPTVDIAKYEKRIDEISQALDEIDMEEIKRQVLNNHIMPLSRPGTPNLGAARTQMSSLSAIARMDDLTAVITATTVQALPNLYKLTRLMECWSLRLMVLRRVPIFLDSLADAETALQSAWHAVERAGARHLPDGSSSPLTRAEYDVMKGVLERKVAKAGRDLDAMLDMLEGQPDTLPEDWIDRMDNLEREYGTWTVACEKKLKELELAALKVVERKSVENSGSDAPSESPKKNTDNHPVIIKIHPTEEGKGLDGSQDALDSDSIPDTDCELSDAEGRSSRSRARPSADSRRSSGMTESTVIHDPQTDMDSFSSEEPEAEYPEPACPPCELSSSFPPPPARSGRRSMSVSFNDKPTVTEFDSFPSPPGTPAKSDDNMSDDDMATEPNTPTECILPPADEKLQKKISEILQSVPAKIRLTQAPPNINLNPPDFKMPTARKSSKPDPMSRSHSNMSLRSAYSSRSATPSFTLAPAFTSRPSRSRNRNYNPEIKLYHLSRSNGEAPIKLFIRCVGEHGERVMVRVGGGWADLGEYLKEYAAHHLRRSGAASEPSKIEVKDVPKNGPVNASNSRRASTSSRPGPDSTPPSRPSSSLGTSPTSPLRLRKTRQRTDESACRPKTPVAGVDAAITTPPPSDTCSVSQSFSSSCSSAPRGPRSRPGSRAGARAVSAGNATMRMPWLSDDLAEEGEPVPLGMAGPKAKQLDMLSEEGRAWVETVKEKVRVASSGGLPSAADKKQQPLGGEGGLMEGFTLREMGKVGGTKRLFKKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGD2</accession>
    <name>G0SGD2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED5</name>
        <name evidence="11" type="ORF">CTHT_0065900</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Mol. Cell" volume="81" first="1781" last="1788.e4">
            <title>Mediator structure and conformation change.</title>
            <authorList>
                <person name="Zhang H."/>
                <person name="Chen D.H."/>
                <person name="Mattoo R.U.H."/>
                <person name="Bushnell D.A."/>
                <person name="Wang Y."/>
                <person name="Yuan C."/>
                <person name="Wang L."/>
                <person name="Wang C."/>
                <person name="Davis R.E."/>
                <person name="Nie Y."/>
                <person name="Kornberg R.D."/>
            </authorList>
            <dbReference type="PubMed" id="33571424"/>
            <dbReference type="DOI" id="10.1016/j.molcel.2021.01.022"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.58 ANGSTROMS)</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 5 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696889.1">
        <property type="nucleotide sequence ID" value="XM_006696826.1"/>
    </dbReference>
    <dbReference type="PDB" id="7JMN">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.58 A"/>
        <property type="chains" value="E=1-1099"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGD2"/>
    <dbReference type="EMDB" id="EMD-22397"/>
    <dbReference type="SMR" id="G0SGD2"/>
    <dbReference type="STRING" id="759272.G0SGD2"/>
    <dbReference type="GeneID" id="18260628"/>
    <dbReference type="KEGG" id="cthr:CTHT_0065900"/>
    <dbReference type="eggNOG" id="ENOG502R1HB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004096_0_0_1"/>
    <dbReference type="OMA" id="LYVYINA"/>
    <dbReference type="OrthoDB" id="5322661at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014801">
        <property type="entry name" value="Mediator_Med5_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35784">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35784:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08689">
        <property type="entry name" value="Med5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="13" id="KW-0002">3D-structure</keyword>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="888"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1032"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="888"/>
            <end position="902"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS17271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="7JMN"/>
        </source>
    </evidence>
    <sequence length="1099" mass="118677" checksum="AF2D35CCACC06EF4" modified="2011-10-19" version="1">MVTVTDPLTARLEAAIKAWSDFFSDAEHERLDPAIFADQSQTLFANHPLAPVPLADLLLRPTPSNRECVDQRTLQYLQVLQKQGRITTAAVLRALYKYSTAHTRAQTPDGKPKHGAGDSSTNDADVGGSSKADLTSRMVRWRNSYMVEEDVLWRLARAVNHGTGIKTSHDVTEVAKVLARWTALFAEVSAAISRDAFNSMNGLQVKDESEDARNAFVLFYFAFCENQLVNETLSQPVCKDICRKLLDSLDAFLPTLMHLTADITGRLEHFRSEVLARYAPQEKKSMDMPSFMNDLSMSLESFQVPELPVVNTRAGLYIYLGAALVGRPMIDDEALFSYLHNRYQGDLQAMAVHLILASFDLLANAVFRNEGAKTGHLLKSFLINKVPLILVQLVAYAATTMYPFNAEMCITEALNQVDINMFPTLSGMFDMPNNNSFNDSVRQDFCFACQLHGLLSQAAIETLLGDITYQSLPPEGRYVKEQLVQACLQEPDRTLKLIGELDNMNGNVGAAAQAIVEICRDLASKPLSLDVLLLFDKPHKILHPLCELLDNWAGYEEDHGEYQPVYEEFGSVLLLLLAFVYRYNLSTADLGIRSSGSFVAKLLNGVDRCQPLEQLSEQEKSHLGGWIHGLFDTEAGGLGDELMSSCPPQDFYLLAPTLFHQIVNALSAGYLTDEMLKGGLEYLVDVLLLPALVPALLYLSNLLWADNQPIQNAVIKILQPILKPTSISNEASTMLSSVLNIVAKPLEHALKSYQRQDPECQKIEPLLLAIADNLAVSRRTGGADHTELESWCSAQITNPATGALIHGGLAAAVRTTIQQLVQWAQNPTLNSMNGMPAPYTHRQTLAAQQILGPHRLLGIILDELKSSPEPGIAYDVVTTMICAPDVRNSTISSPSTQSNNSSDHNDQAQNHQSQDAKHKHPHRLTLRDALRLEAHDFRAHLRADPVLAETVVRLYRRVEAQLTPLALPLPPAAAAAPAVGVNVGVDAATAAAAAAAAAMMPDALGLGVVGGVELGGMEGAIAAAVAAANGSGTGGAGGDGTQGGAGDAGMGLDGQQQGQGGSSAGDMGLGGGTADDIFSGLSGPDDFGADFGSWSMDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGF7</accession>
    <name>G0SGF7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0066160</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696914.1">
        <property type="nucleotide sequence ID" value="XM_006696851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGF7"/>
    <dbReference type="STRING" id="759272.G0SGF7"/>
    <dbReference type="GeneID" id="18260654"/>
    <dbReference type="KEGG" id="cthr:CTHT_0066160"/>
    <dbReference type="eggNOG" id="KOG1315">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024136_0_0_1"/>
    <dbReference type="OMA" id="WVWAEII"/>
    <dbReference type="OrthoDB" id="302728at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="12">
        <location>
            <begin position="168"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="344"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="482"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="555"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="346"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="495"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="580"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="636"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS17296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="659" mass="73455" checksum="9C50051A56903BD9" modified="2011-10-19" version="1">MDIITNNTSSRSLSPSPSPSPNPASASPLYPLDSRPPLDPLTLDPSTRPPSPLHFDSTDDDMRSPRRWARRLERTCCACARYFPLAFVYSLTTWAAWVLVKLCSTPSRVEWLGTPAAVAGIVLYLMSNWCYTTAVFTPPGSTTNEYGYSTLPTTAPPNMTSFTVKSNGQMRFCKKCQARKPDRAHHCSTCRRCVLKMDHHCPWLATCVGLRNHKPFLLFLIYTTAFSIYCFCASGSWVWKEIFDTNTTYVDEFMPVMYIMLCIIAGIIGVVLGSFTSWHIYLAAKGQTTIECLERTRYLSPFRESMHNAFRSSHAPGNGNANAVPPPSYGQQLLEIHRNALPGITRPEEGEELRPDPSPRGVGFNSMPYADVTRGPQYQAGTCRYTPDEMERQRARQRYLDYLDEQDSSKLPNAFDLGVKKNLLHLMGPNPWLWMLPICNTTGDGWTWEPNPRWLEARERIARERMEQIERERRAGWGYDEEEAVGGYGTPQPREGGKTPTKADRVLGRDPNLYADVGVVAGHNKRLQKKREEVLAMRRLSPGGRTIEEELEEIDGLSDGEEEKPQQSSQSQPPPKPATASRQPLSLVTNTSHSNGPTIPTAPRWSPAGTATAASKLFRGPTPNSPLSPMGFPGVSNSNSRSSTPSNGNKGVDDDDELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGG0</accession>
    <name>G0SGG0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0066200</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL36 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696917.1">
        <property type="nucleotide sequence ID" value="XM_006696854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGG0"/>
    <dbReference type="STRING" id="759272.G0SGG0"/>
    <dbReference type="GeneID" id="18260658"/>
    <dbReference type="KEGG" id="cthr:CTHT_0066200"/>
    <dbReference type="eggNOG" id="KOG3452">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140672_0_0_1"/>
    <dbReference type="OMA" id="NKGHKTE"/>
    <dbReference type="OrthoDB" id="9616667at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1760:FF:000003">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1760">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000509">
        <property type="entry name" value="Ribosomal_eL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038097">
        <property type="entry name" value="Ribosomal_eL36_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10114">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01158">
        <property type="entry name" value="Ribosomal_L36e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01190">
        <property type="entry name" value="RIBOSOMAL_L36E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS17299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="107" mass="12003" checksum="37C6A2F284BCF848" modified="2011-10-19" version="1">MAAKKFETQRTGLAAGINKGHKTTARVAKRVSHTKGHLSKRTAFVRDLVKEVAGSLAPYERRIIELLRNAKDKRARKLAKKKLGTFGRAKAKVEDMNRVIAESRRAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGG3</accession>
    <name>G0SGG3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0066230</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696920.1">
        <property type="nucleotide sequence ID" value="XM_006696857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGG3"/>
    <dbReference type="GeneID" id="18260661"/>
    <dbReference type="KEGG" id="cthr:CTHT_0066230"/>
    <dbReference type="eggNOG" id="ENOG502S5IN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047851_1_0_1"/>
    <dbReference type="OMA" id="CGEWRER"/>
    <dbReference type="OrthoDB" id="5427526at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="415" mass="44483" checksum="57B88EE18CFCFFBB" modified="2011-10-19" version="1">MDSPRQTPQHSPNPSINDFQQFSFSASNSYYEGSPHHDRRYSKASASSFNESIAGSTSGLPLDGPDGGAGGKGLGNLADELAAFDDDGYDDGYGDGEGYDEEGASGYEDEREGAGVGIGISLDQADDAKREGVRDSGVDVESPRRRQGGVGGSGGGGLGVPSGTNGRRHRRAGSEYDGSEYGTDSDLESPGIPPRLAEKMAEVEALARRGTENNGSSADGTFKRVTDGLRDLGSQAGIEGAASRLITAHSALTTHLTHQTRLLHNLTYPLISSHNQSHIDPDSIDSLLPLLLSLQSTLPRPATPALHALSSLQNLTQDLIHTLNYLSDTLHMSRQTTTAAARKLKSARDVVAEMRRDEELREEGVRWLERGNWGERLARRECAHVCGEVVGGFEKVCEGWRERLVKALKEESSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGL6</accession>
    <name>G0SGL6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">M protein repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0066770</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696973.1">
        <property type="nucleotide sequence ID" value="XM_006696910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGL6"/>
    <dbReference type="STRING" id="759272.G0SGL6"/>
    <dbReference type="GeneID" id="18260715"/>
    <dbReference type="KEGG" id="cthr:CTHT_0066770"/>
    <dbReference type="eggNOG" id="ENOG502S2WH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016578_0_0_1"/>
    <dbReference type="OMA" id="HEVYRKQ"/>
    <dbReference type="OrthoDB" id="5413982at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF66">
        <property type="entry name" value="OS04G0158400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="589" mass="64240" checksum="BEF9D64E2AF89F64" modified="2011-10-19" version="1">MDDEKLKAEKMAAAKKKFEQMRKAKAKKAGKKGVGGDDASKKEEASAAAATSAEPGTPTSSTAGEGVAEGGKEERDKGEDVSEVQEEKTEQAPEEQPAEEAPAEAEEEPVPAPVTKTPSLAQQSKARSRSFRQGSISITTGSTPLSPGGLISPVGEGGETAPDIYRKQAQRIEELEKENKALAKEVRDVEKRWQRAEEELADLRERDLGDEGEVARLKKEIEALQRQNAQLQAQISRSGSGASSRHGSSPSLSLASPPAAATAELEAQLRSKSATIETMELEMSRLRAQVERLSLSASAPSEQIAALEEKLARAEKAAGVAQREVNDLKAELENASKKAVKEGSERASAETKVKILEKEVETLKGEKEDLAKKVEALEKKVATLTTLHKEQEGRMSALRKEKDSLEEEIKRLKKGGEGGIDDEGMDELEDEERRRLEQRIRELEAENTDLRRGIWIEKRKEMQMPPEGETAVRFESVDLDHGGHLSPHVHAHGSKKGGGLGDLLATGLNVLTGGGTTATAGGGAFDDLLDDDMEFDEEAFRRAQEEEQKARIERIKELKRTLKNWEGWRLDLVDIRRGGGEGIGEIFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0SH34</accession>
    <name>G0SH34_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitination network signaling protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0068530</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697141.1">
        <property type="nucleotide sequence ID" value="XM_006697078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SH34"/>
    <dbReference type="STRING" id="759272.G0SH34"/>
    <dbReference type="GeneID" id="18260891"/>
    <dbReference type="KEGG" id="cthr:CTHT_0068530"/>
    <dbReference type="eggNOG" id="ENOG502QSPS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005822_1_0_1"/>
    <dbReference type="OMA" id="NNAFWQP"/>
    <dbReference type="OrthoDB" id="4158994at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898:SF2">
        <property type="entry name" value="NUCLEOPROTEIN TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898">
        <property type="entry name" value="NUCLEOPROTEIN TPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="584"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="891"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1023"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="616"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="39"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="893"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="917"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1041"/>
            <end position="1057"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS17523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1074" mass="114844" checksum="C8FB8D77CD51E4D4" modified="2011-10-19" version="1">MPRPSSSAKRHPGAASSRDSRHEIGSVGPGKRVARNKSQVQGQNQNQNQGQLNGSAVEKAATSPSAAAADSSYSVSSSSVPPSPASAAAVANAPPSAYLLPDDMSSDRKLADGIRRGSLATTYSDSSADSLLDAHVPAAAHSVPEETTHRRIDVNDAKNTNVHRDPGPLDFAVTVLRACPLQDTIAILIILMQASPTVLATIYMLFTFLTFVPPVTTNSGLSITEIFDGSQGTPSLSTLIVMDFIMLGIWVFLWAPMQQFILDLAQVVISLTLGGGGTSNRGTTSNILLCVLIVGVSHWTHYSRWNGLSRVSSLFGSSRFLSSNDEPVRPLERKGTYGWVRSILAIHILTQGLVRCIREWYLRRERRDQQLQGLFDPEAGKLAAFSPDGCSDAALMAAESEAHLQASAAHLSSKKRRKQSAQVRVRQPLWAALASTKIVMVKEYELSHAASESAGSNATDIHNLGNAPFNTQPEQIWICYVGCDEVCFNTSHFPHQSDYGEIVTEDNKPGIDMSKPFYVRVNNAIWQPTRIIPLEDDEERKYQGTRWTGDIYGLTPLSNYEFEFVSTRTGEIIFSTSVRTIQAKNKDPETAPKTAPSNSRTLARHDSPVTTLRASIAAAELKLADERARLKAVRRENNRRLNAARKEIEKLTSAVQSAGGDDEKLRQKIAQNRIQEKRAEESISELETELKELETVPEELLAKHRASHDAWTSEKARFDQARANFKNFKQAIDKQIKALEEERASLQAKRNKIATRIAKVDDEHARITDANAKGLNEAERRRQERANLEAELARAEQNLRDRIQSIRSSNLNKQVQLHDMAAQMQAYLASFQDDLAAYDVAGHYPGASGQVGPWHSSAPAPTGAYPATSGPVGPWPPVTMAPSQYPFANSIQPSPALANSAPALNSTPPPQHRSRGRSSSMLSSVSGFTQSTDEDTDLGAIGSGRGAGTRAMATASVTATSNANSTASVNINITPGAVRSLPPGLFPPLLASGSGSVPGLLKTPGFGSTGSVGSVASTGSAFGSGSASVSGSGSGSGLGSGRSSVRSRGSGSGASLEGAEAVVGITSAAASAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHF1</accession>
    <name>G0SHF1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative metal ion transmembrane transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0069800</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697258.1">
        <property type="nucleotide sequence ID" value="XM_006697195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHF1"/>
    <dbReference type="STRING" id="759272.G0SHF1"/>
    <dbReference type="GeneID" id="18261018"/>
    <dbReference type="KEGG" id="cthr:CTHT_0069800"/>
    <dbReference type="eggNOG" id="KOG3907">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028824_0_0_1"/>
    <dbReference type="OMA" id="DDFPSIC"/>
    <dbReference type="OrthoDB" id="19859at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045891">
        <property type="entry name" value="ZIP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER , MEMBER 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133:SF0">
        <property type="entry name" value="ZINC_IRON REGULATED TRANSPORTER-RELATED PROTEIN 102B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="70"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS17640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="284" mass="29682" checksum="48ED2AC7E39FC966" modified="2011-10-19" version="1">MAGLFFLIVTSVVMAVASFLAGALPLSLSLSQSQLRLIAALGAGLLVGSCLIVILPEGIEALSADRIHSPEPQHVHSKPPASGRVLRAEEPVSPSTPPPPPELPAFHIGFALVLGFALMFLIDRLPRHASEIFQTQTSRHVSLDNLAGQSGEEESDGFLGSLTPSPRQTRSLATTTGLVIHAAADGIAMGASATSANWNVGLIIFIAILVHKAPAAFGLTSVLMKQGLSKRAARVHLLVFSLAAPIGALATYFFVALLGDESAEGEGAHWWTGMLLLFSAGTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHG9</accession>
    <name>G0SHG9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutathione S-transferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0069980</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697276.1">
        <property type="nucleotide sequence ID" value="XM_006697213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHG9"/>
    <dbReference type="STRING" id="759272.G0SHG9"/>
    <dbReference type="GeneID" id="18261036"/>
    <dbReference type="KEGG" id="cthr:CTHT_0069980"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007681_2_0_1"/>
    <dbReference type="OMA" id="TGMMHGW"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45613:SF9">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR CCM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45613">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="651"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="885"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="306"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="887"/>
            <end position="899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="952" mass="105965" checksum="7BF560D5F823C7C2" modified="2011-10-19" version="1">MPSFGTTTRAAIVRDVCLRCQFRLLLASRAHARQGHIRWSSSFPGVGGSSAAPVGGEPHEPSPNGMPSVQQPASEGSPSSYPSPLQRPSSRKSSSLAMFQSIVESQAKGPINSQVNSAPTSDTPPVASGGAASIQLVKDIAIIQNMLEKEEATIAEAYAFFEKTVYPQIKKSGAVLPQIAKNQLTNVLLNQLAAEKPRDFDSNKLPSVTRITEIMVELDALRPTIWGTLMIQLIQRILHQSTSPEDYYSIESFDSAMARRNALLRDLVGAWKAFSQQMVSEEELASAGPKTFSQRMVSEEERESAEQSPEAEQESGSPPKSKPTKPAFQEVLDAKYPKHLDSKPTLMEAMGVMFPRYQGPSLLRPTFAAYATYKLLTDPVNQTRTMRPVARPFLQMMKTLIFRSRSPRIADFGPVFENFPEMLRFMQTDGPANEGASSFVLSPVSFPRQNWEQLKIDIHQRIGQAIKIRNIGVLNKTWSDFWGPEPTPDAARIEQLIKCDELFNYFVMAYQALRRPQLAIQVWNGMERIGIKPTIKTWNSMLQGCAMCRNANGIRAVWGKVIQSGMKLDAPIWTARIAGLFACGEPDNALRALQEMAKVWSMRDDPQFANVAVQPTVGPVNAAIAGLIRCNREDDVRKVLAWAAKQGIDPDIYTFNTLLGPLVRRGDMEAIGEIFDMMRAINIKADVATFTVLLEGALSDITALTPEQQVNLVNRILHEMRSSGVPINMEAYAKIIYILLNQSGDRTGKAVKTVLAHIWRRGLELTSHIYTMMAEHYFSRDPPDSRAVTALIENRKLSENPNIDRVFWERVVKGYCQAATRLAELGYSDGMDEVQRAMAIFDRVFVPGATITFSALFELLRALVERNEMAAAKRVVDAAVTIGRSEADEEGGGEGEGGEGESQKPRASVFAAQMPPGKRYWRHRFWHLAYQYGLLDEKTQSLFFGGQRRLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHJ1</accession>
    <name>G0SHJ1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4484 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0070200</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697298.1">
        <property type="nucleotide sequence ID" value="XM_006697235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHJ1"/>
    <dbReference type="STRING" id="759272.G0SHJ1"/>
    <dbReference type="GeneID" id="18261058"/>
    <dbReference type="KEGG" id="cthr:CTHT_0070200"/>
    <dbReference type="eggNOG" id="KOG4704">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019791_0_0_1"/>
    <dbReference type="OMA" id="GYTIVWK"/>
    <dbReference type="OrthoDB" id="2152680at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028115">
        <property type="entry name" value="DUF4484"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018626">
        <property type="entry name" value="LCHN/Anr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053056">
        <property type="entry name" value="Lipid_Metab_Assoc_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28153:SF1">
        <property type="entry name" value="DUF4484 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28153">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09804">
        <property type="entry name" value="DENND11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14831">
        <property type="entry name" value="DUF4484"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4484" evidence="2">
        <location>
            <begin position="435"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="651" mass="71003" checksum="F4688EA8C904C71F" modified="2011-10-19" version="1">MAASRGGQPSLSVHLPQPSSSSSIPDVPPISALFLIDFDVKAGYTIVWKQAVPGLALDGAVEYKSLPSGLHSVSNDLIYFVHEGTHAGLSAFINKPTDEEESRHARMIAVGVLVPLSFGRLGRAWRHAENLKEMAEKLATDKTQTQILQEYWEKHCVRESSASEAPKDTPLESPLLTVPGPSRSTPGRGHSRNRSASDGAALIPAEQRLSPYHPALSLTKLLDTFGPLIFPIHRAALLRKRILISCHAPVHEICNFVYDISVIANIPVPVCDIIDPSAPVERLRPLFTIGIHDIGTLIEQRAPLKRGSQGDNQDDTAQVDSSQGWIACTTDSILAMKEGLWDMLITMPPPHTVNARQRIWPQVECPKGVPVKATQRDLRRFQSLTKGLARIEAAMRQSGEAAPETPGILPSRTSVETARPYEFLPPGVEEMDKIVEPITWAAIAYNGFLWWASAGERRRAGELEEQHQDAALLADLGGPMRPRPRSRPSSSGPDNQGQTQMADSLASLTQTSVHTDDDSAAQAQAHLELAVVAYFHRLTTTFISVLADIIDSTDDDDLMGLDPDDLDVLEPAALAATGTSDDQTGEEERRLLGSGNSRGWVRVDGDALSAMGLDVWSKADAAFVKELTTRYFSRRAHVQNRGFEICGVRVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHQ8</accession>
    <name>G0SHQ8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tetracycline:hydrogen antiporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0073030</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS16978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697560.1">
        <property type="nucleotide sequence ID" value="XM_006697497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHQ8"/>
    <dbReference type="GeneID" id="18261341"/>
    <dbReference type="KEGG" id="cthr:CTHT_0073030"/>
    <dbReference type="eggNOG" id="KOG2615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_54_6_1"/>
    <dbReference type="OMA" id="IWQMILF"/>
    <dbReference type="OrthoDB" id="419616at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="47"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS16978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="489" mass="52883" checksum="E7AEF746F737C7E1" modified="2011-10-19" version="1">MRSSSENGVRDATEQTPLLSSINNTVNTEQHHDDGSKPDEKPLPIWQIAALCYARWVEPVAFFSIFPYINQMAQENGQLADTDVGFYSGLIESLFSLTQMLVMVLYGRAADRVGRKPVLVFSLTGVSFATMLFGLARTIPQMIIFRCLAGVFAGTIVTIRTMLSELSTPATEARVFSWFAFTGNLGILIGPLIGGALVDPAHQYPSLFGHIRFFHDYPYVLPSLVIGTIGLTAVAVTSLFVQETLVKAKQPYPLNGSSLGTPSKPPSTWNLAKSPGVPIVLYTYGHIMLLAYSYTAIIPIFWFTKVSLGGLGFTPLQISLMLGLNGLAQAIWTLLVYPPLHARIGTNGILRACAIAYPFFFGTCPLMNALLRSNIPGAESIFWAVAPPLLCLGVGVSMCFTAIQLALNEVSPSPVTLGTLNALALAISSGVRSFSPALFASLFAVGARTQALGGYAIWVLMVVLAGGFTVVSRRMPDYEAIRRARIERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHV4</accession>
    <name>G0SHV4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0073500</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697606.1">
        <property type="nucleotide sequence ID" value="XM_006697543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHV4"/>
    <dbReference type="STRING" id="759272.G0SHV4"/>
    <dbReference type="GeneID" id="18261388"/>
    <dbReference type="KEGG" id="cthr:CTHT_0073500"/>
    <dbReference type="eggNOG" id="ENOG502TCM7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010785_0_0_1"/>
    <dbReference type="OrthoDB" id="5244857at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="670"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="767"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="701"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="786"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="912" mass="100597" checksum="55C5E0C1F592FE3D" modified="2011-10-19" version="1">MLSRPAFSIRKLIPQKKQDEVPEDYTGSYFIHDDDMDTFSRIKSWMPPTMGLMKKPKPMIDIRRSDDLHRIVYPPPPPLPDTPPSSTTSLSSYENNNAAVYAINATARPCPPRPSERGTQGSPQRSPQRSPLLSAQSCEDIQSTIQFRTIVHANTFPPQFQFTPPSSPPQLEGMGQNKVVLAPKLPLEATAELPPTPAIGTHTTSPDSESGAANPLTADAKGLFLTSAPQPAEKADISQLRQSYSHAILSDQQLEKFPKPKTATSVSTITRRKSQQRSHGSVRSNRSTRSNRSVRSATKTATRSELSSGQKRVVVASTPKRVKSKKSGIRPRVRARQSSVWQWTESAKGLMRERLFHRIEVDEMLPESELREIRKSRATKWTCSPELGVTHVSERFRKVTKKPAEPAEPIEPLDLNVARDAPTETSTPQSCLANQQEHDECPTSKAATQEQVSSKPGNSRQQELQNTLENAPAPTLPDSPTKGNNEAERTSPVAIISEEDCSAQPTSVNSEPTVAPTLKSPSHRRNPSRQLPPLPALPEAAPSSVENKTSPSPTEQSESRPEQPAAPAPQHVSTKFIEEDDEYVYLRSTPYTMTMPTFQHGRIRLSKPERAAAVDNTLDWTAFQMAILGGAGDFFGEATDYSRPSDTELDELENLISWFNSFGFEGYGRLVGPEPPKTPNRTWTPAMSSTHTRTPSLTAQSPASASGAGSSPNLGAETGFRRIDPPAPATAQESYYYRNYCQQQQYNTPHVNNEFGFYPAATMATPSQYLTPPAPDASQRHRRNESSSTFSVYRTSPQHLSQPQPSPAFYHQNTWPQSHPAYTYDYQPQPQLPKPLAQPNCVDVSIDSAKSRQRSNSIDSFQSLPQSPMMDLVVSHDAGGNEYVVPMGFNLSHDLGDFLTWHASHVSGVGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHW4</accession>
    <name>G0SHW4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GID complex catalytic subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glucose-induced degradation protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0073600</name>
    </gene>
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        <lineage>
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            <taxon>Dikarya</taxon>
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        </lineage>
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    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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            <dbReference type="Proteomes" id="UP000008066"/>
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</entry>
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        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
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                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
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                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
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        </source>
    </reference>
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            <end position="171"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="415" mass="46476" checksum="BEE596E9B5F61796" modified="2011-10-19" version="1">MSGCSWSWPYWKFGLKKDDLTTSLHDRYNTVTIPILDPEAFHHDVCEIAHLATSPEEFLGMLEKRKEQRLQELNEILESAALEIIANPTFIGNEQWQPAIQLFRTKSFDSLVRFFASYLPADHPWYKPAQPKSGTCYQDSSSGSFDGSSGTVFDEPESMSDSTDTGSHETLSSKAYYSDSHRSMTMCSDSSVASPSDNFHDYDDSRPSTPGRAYSFSESEPDCCPSSTGECNCREQFSSPGLTSNLGQYTPGSKLLISPDYESRPNHSLFSGTKTCTTKTYVTIFICIDGRKYYRAVHFSAETSKSVFITGATITIRSLSIQQTQHNRIQPGSTSNKQTKRAQPGKTGKISIKISRTIEKRKKNESASRGHFPDKQATKTEGHSIRGAVNTVAPKIVGYSETSWWWQTVFFYHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0SI45</accession>
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        </submittedName>
    </protein>
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        </lineage>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
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            <authorList>
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                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
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                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="174"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="3">
        <location>
            <begin position="366"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
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    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS17115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="793" mass="87604" checksum="047685B19E1BC493" modified="2011-10-19" version="1">MKLISVLTREVEEFHDDKVPPYAILSHVWGPENDEVTAQDLQGIAQHRKAQREARRNNAPLLTQGHHHHEPISGVNGVNGHSSTGRPSLDSTETMRLMLLTSMLMAFRGKTSPSIGNNLLRNLPALKDTTSTTTNGYSESYEIERANRNGESHHQRYSSLEVLAQAAASASTHQSTNTGPHPAELKPGYQKILYAVEQAEKDGFEYVWVDTACIDRTSSTDVSEAINSAFQWYSRAGICYAYLADVQADDNIEGYRTWLDLFNMSRWFKRAWTLPELLAPKKLVFYAKGWKLLGTKSSLVKHVARVTKIDEVTLIEPKLVHKASIAQRLAWAAGRQASRPEDVAYSLLGLFGIHMPIVYGEGAEAAFQRLQEEIIKRSDDHSIFAWGILNQLLGPKPRHTNTLPPSALCLDEEADDESDENLAGATPILARSPDDFANMQFVIVPQSPEVNAPAGVADYSMTNKGLHITLPLLPDPAGGARYVLALLPCHLSSDPSHRLAIPLSVTAIPNVYLRVKPGTLGAPSSEALLVPVSVLKEGKCENKRIYIPNVTEQIARLRQREEIIFLRATDVFSPGYEIVQVCGLGGKFATFDRKANVVKVGAVSVTGAGGAEMDEEEVRRMMSKNRAALYRLVVCQLAVVAFWSQHIKSGFIARILVEVTPSGQGGRCWVDLASDPRINSQDQICAEAQRLWEDPGSVDVTIPSLTGSPGVQMVTMEIVHPERYQPGVSGLDLSEGGWSTVQSAKLGVFDNCTFVEMWEREYMRTVQAKLERKKKGLMELSMTSMLWMAPDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G1DJ99</accession>
    <name>G1DJ99_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">NADH-ubiquinone oxidoreductase chain 3</fullName>
            <ecNumber evidence="9">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_m000280</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="10"/>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="12 13 14" key="2">
        <citation type="journal article" date="2022" name="Sci. Adv." volume="8" first="eadc9952" last="eadc9952">
            <title>Conformational changes in mitochondrial complex I of the thermophilic eukaryote &lt;i&gt;Chaetomium thermophilum&lt;/i&gt;.</title>
            <authorList>
                <person name="Laube E."/>
                <person name="Meier-Credo J."/>
                <person name="Langer J.D."/>
                <person name="Kuhlbrandt W."/>
            </authorList>
            <dbReference type="PubMed" id="36427319"/>
            <dbReference type="DOI" id="10.1126/sciadv.adc9952"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.44 ANGSTROMS)</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the complex I subunit 3 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="9"/>
    <dbReference type="EMBL" id="JN007486">
        <property type="protein sequence ID" value="AEI26007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004769780.1">
        <property type="nucleotide sequence ID" value="NC_015893.1"/>
    </dbReference>
    <dbReference type="PDB" id="7ZM7">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.77 A"/>
        <property type="chains" value="3=1-146"/>
    </dbReference>
    <dbReference type="PDB" id="7ZM8">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.76 A"/>
        <property type="chains" value="3=1-146"/>
    </dbReference>
    <dbReference type="PDB" id="7ZMB">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.75 A"/>
        <property type="chains" value="3=1-146"/>
    </dbReference>
    <dbReference type="PDB" id="7ZME">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.83 A"/>
        <property type="chains" value="3=1-146"/>
    </dbReference>
    <dbReference type="PDB" id="7ZMG">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.44 A"/>
        <property type="chains" value="3=1-146"/>
    </dbReference>
    <dbReference type="PDB" id="7ZMH">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.47 A"/>
        <property type="chains" value="3=1-146"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G1DJ99"/>
    <dbReference type="EMDB" id="EMD-14791"/>
    <dbReference type="EMDB" id="EMD-14792"/>
    <dbReference type="EMDB" id="EMD-14794"/>
    <dbReference type="EMDB" id="EMD-14796"/>
    <dbReference type="EMDB" id="EMD-14797"/>
    <dbReference type="EMDB" id="EMD-14798"/>
    <dbReference type="SMR" id="G1DJ99"/>
    <dbReference type="STRING" id="759272.G1DJ99"/>
    <dbReference type="GeneID" id="11030316"/>
    <dbReference type="KEGG" id="cthr:CTHT_m000280"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030964">
        <property type="term" value="C:NADH dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1610">
        <property type="entry name" value="NADH:ubiquinone/plastoquinone oxidoreductase, chain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000440">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038430">
        <property type="entry name" value="NDAH_ubi_oxred_su3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11058">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11058:SF9">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00507">
        <property type="entry name" value="Oxidored_q4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="12 13 14" id="KW-0002">3D-structure</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AEI26007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="7ZM7"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="7ZM8"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="7ZMB"/>
        </source>
    </evidence>
    <sequence length="146" mass="16317" checksum="B52A834DABE8FDA2" modified="2011-10-19" version="1">MSAMSIYIIFVSIIAILFLAIDLIFAPHNPYKEKLSAFECGFHSFSQSRSPFNISFFIYGLVFLLLDLEILLLYPFAVSEYVNSAYGLAAALIFIGIITIGFVYELGHDALKVHSRQNISTKDLKSSVVISYLGNINNDSVNLHIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G0RXX4</accession>
    <name>G0RXX4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alcohol dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0004620</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691002.1">
        <property type="nucleotide sequence ID" value="XM_006690939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RXX4"/>
    <dbReference type="SMR" id="G0RXX4"/>
    <dbReference type="STRING" id="759272.G0RXX4"/>
    <dbReference type="GeneID" id="18254500"/>
    <dbReference type="KEGG" id="cthr:CTHT_0004620"/>
    <dbReference type="eggNOG" id="KOG0023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_20_1_1"/>
    <dbReference type="OMA" id="YKGLKMT"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000002">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="9">
        <location>
            <begin position="19"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS23760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="353" mass="37774" checksum="8DECBD8103F7B54D" modified="2011-10-19" version="1">MTTFEIPSEQWAAVVEKTGGPVVYKKIPVQKPGPDEVLINVKYSGVCHTDLHAMKGDWPLPTKMPLVGGHEGAGVVVAKGSLVEDIEIGDYAGIKWLNGSCLHCTFCRQADEPLCPHALLSGYTVDGSFQQYAIAKANHVARIPKDVDLEAVAPVLCAGITVYKGLKESGARPGQYVAIVGAGGGLGSMAIQYARAMGLHVIGIDGGDEKGQSVRSLGACAYVDFTKSPDLVKEVKEATPDGLGPHAVLLLAVSEKPFQQATEYVRSRGTVVCIGLPANAYLKAPVFDTVIRMINIKGSYVGNRQDTQEAIDFFQRGLIKVPFKTVGLSQLQEVYELMEAGKIVGRYVVDTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0RY95</accession>
    <name>G0RY95_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0005900</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S9 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691123.1">
        <property type="nucleotide sequence ID" value="XM_006691060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RY95"/>
    <dbReference type="STRING" id="759272.G0RY95"/>
    <dbReference type="GeneID" id="18254628"/>
    <dbReference type="KEGG" id="cthr:CTHT_0005900"/>
    <dbReference type="eggNOG" id="KOG1463">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029573_2_1_1"/>
    <dbReference type="OMA" id="ESKIYHA"/>
    <dbReference type="OrthoDB" id="1418352at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000010">
        <property type="entry name" value="26S proteasome regulatory subunit RPN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040780">
        <property type="entry name" value="Rpn6_C_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040773">
        <property type="entry name" value="Rpn6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18503">
        <property type="entry name" value="RPN6_C_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18055">
        <property type="entry name" value="RPN6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="223"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS23881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="423" mass="47999" checksum="9ADB13F68BCCCF20" modified="2011-10-19" version="1">MAQEDSEKVREAQKLAKINPEKAIAIYKEIIAQPPSVTNEAAIREYEVALVSLGELYRDQRNTEALVGLVTTSRTVLSSFAKAKTAKLVRQLLDFFDAIPNSLEIQIAVTKSCIEWAKSERRSFLRQNLETRLVQLYMAKQSWYEALTLINGLLRELRRMDDKLVLVEVQLLESRVYHALGNISKARAALTSARTSAASVYTPPLLQANLDMQSGMLHAEDRDFQTAYSYFIEALDGYHTQEEPQKAQAALQYMLLCKIMLNLVDDVHQLMQSKQALKYAGRSLEAMKAIARAHANRSLEEYERALAAYKYELGSDAFIRNHLRRLYDNMLEQNLIKVIEPFSRVEIDHVARMVGLDTQQVERKLSQMILDKVITGVLDQGAGCLIIYDETQRDEAYDAALATIEKLSNVVDLLYTNQASLLE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-08-03" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYE0</accession>
    <name>ODPB_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate dehydrogenase E1 component subunit beta, mitochondrial</fullName>
            <ecNumber evidence="3 4">1.2.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pyruvate dehydrogenase complex component E1 beta</fullName>
            <shortName evidence="6">PDHE1-B</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">CTHT_0006350</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2021" name="Cell Rep." volume="34" first="108727" last="108727">
            <title>Integrative structure of a 10-megadalton eukaryotic pyruvate dehydrogenase complex from native cell extracts.</title>
            <authorList>
                <person name="Kyrilis F.L."/>
                <person name="Semchonok D.A."/>
                <person name="Skalidis I."/>
                <person name="Tueting C."/>
                <person name="Hamdi F."/>
                <person name="Kastritis P.L."/>
            </authorList>
            <dbReference type="PubMed" id="33567276"/>
            <dbReference type="DOI" id="10.1016/j.celrep.2021.108727"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2021" name="Nat. Commun." volume="12" first="6933" last="6933">
            <title>Cryo-EM snapshots of a native lysate provide structural insights into a metabolon-embedded transacetylase reaction.</title>
            <authorList>
                <person name="Tuting C."/>
                <person name="Kyrilis F.L."/>
                <person name="Muller J."/>
                <person name="Sorokina M."/>
                <person name="Skalidis I."/>
                <person name="Hamdi F."/>
                <person name="Sadian Y."/>
                <person name="Kastritis P.L."/>
            </authorList>
            <dbReference type="PubMed" id="34836937"/>
            <dbReference type="DOI" id="10.1038/s41467-021-27287-4"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
    </reference>
    <comment type="function">
        <text evidence="3 4 7">The 10-megadalton pyruvate dehydrogenase complex contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) and catalyzes the overall oxidative decarboxylation of pyruvate to form acetyl-CoA and CO(2) (PubMed:33567276, PubMed:34836937). Within the complex, pyruvate and thiamine pyrophosphate (TPP or vitamin B1) are bound by pyruvate dehydrogenase E1 subunits alpha and beta and pyruvate is decarboxylated leading to the 2-carbon hydrohyethyl bound to TPP. The E2 component contains covalently-bound lipoyl cofactors and transfers the hydroxyethyl group from TPP to an oxidized form of covalently bound lipoamide, and the resulting acetyl group is then transferred to free coenzyme A to form acetyl-CoA and reduced dihydrolipoamide-E2. Finally, the flavoprotein dihydrolipoamide dehydrogenase (E3) re-oxidizes the lipoyl group of dihydrolipoamide-E2 to form lipoamide-E2 and NADH. A fourth subunit, E3BP, is responsible for tethering E3 in proximity to the core, forming the entire metabolon.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3 4">
            <dbReference type="Rhea" id="RHEA:19190"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <KM evidence="4">148 uM for pyruvate</KM>
        </kinetics>
    </comment>
    <comment type="subunit">
        <text evidence="3">Eukaryotic pyruvate dehydrogenase (PDH) complexes are organized as a core consisting of the oligomeric dihydrolipoamide acetyl-transferase (E2), around which are arranged multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide dehydrogenase (E3) and protein X (E3BP) bound by non-covalent bonds (PubMed:33567276). The Chaetomium thermophilum PDH complex contains 60 E2 units, 12 E3BP units, about 20 E1 units, and 12 or more E3 units (PubMed:33567276). The units are organized in 1 E2 60-mer, 4 E3BP trimers, about 20 E1 tetramers, and a maximum of 12 E3 dimers (PubMed:33567276). Pyruvate dehydrogenase (E1) is active as a tetramer of 2 alpha and 2 beta subunits (PubMed:33567276). The E3BP trimers are bound inside the icosahedral core with tetrahedral symmetry (PubMed:33567276).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="3 4"/>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691168.1">
        <property type="nucleotide sequence ID" value="XM_006691105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYE0"/>
    <dbReference type="SMR" id="G0RYE0"/>
    <dbReference type="STRING" id="759272.G0RYE0"/>
    <dbReference type="GeneID" id="18254673"/>
    <dbReference type="KEGG" id="cthr:CTHT_0006350"/>
    <dbReference type="eggNOG" id="KOG0524">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012907_1_1_1"/>
    <dbReference type="OMA" id="WYANCPG"/>
    <dbReference type="OrthoDB" id="10266385at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000006">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027110">
        <property type="entry name" value="PDHB_mito-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006667">
        <property type="entry name" value="PRK09212.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008854">
        <property type="entry name" value="PRK11892.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624">
        <property type="entry name" value="DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624:SF96">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0630">Potassium</keyword>
    <keyword id="KW-0670">Pyruvate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000456221" description="Pyruvate dehydrogenase E1 component subunit beta, mitochondrial" evidence="2">
        <location>
            <begin position="47"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <note>ligand shared with alpha subunit</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>structural</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P11177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="33567276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="34836937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="33567276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000305" key="7">
        <source>
            <dbReference type="PubMed" id="33567276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="382" mass="41425" checksum="CA1995B8CF153A83" modified="2011-10-19" version="1" precursor="true">MSRFLRPAFRLATTATRASTIRPTPSSLITKAAAVPTTRLLQKRSYAAEATGVKEYTVREALNEALAEELESNPKVFILGEEVAQYNGAYKVTKGLLDRFGEKRVIDTPITEMGFAGLAVGAALAGLQPVCEFMTFNFAMQAIDHIVNSAAKTLYMSGGIQPCNITFRGPNGFAAGVAAQHSQDYAAWYGSIPGLKVVSPWSAEDAKGLLKAAIRDPNPVVVLENELMYGVSFPMSEAAQKDDFVLPFGKAKIERAGKDLTIVSLSRCVGQSLVAAENLKKKYGIEAEVINLRSIKPLDVEAIVKSVKKTHRLLAVESGFPAFGVGAEILALTMEYAFDYLDTPAQRITGADVPTPYAQKLEEMSFPTEQLIEDYAAKMLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYF3</accession>
    <name>G0RYF3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">6-O-methylguanine-DNA methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0006490</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = S-methyl-L-cysteinyl-[protein] + a 2'-deoxyguanosine in DNA</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="3"/>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691181.1">
        <property type="nucleotide sequence ID" value="XM_006691118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYF3"/>
    <dbReference type="STRING" id="759272.G0RYF3"/>
    <dbReference type="GeneID" id="18254687"/>
    <dbReference type="KEGG" id="cthr:CTHT_0006490"/>
    <dbReference type="eggNOG" id="ENOG502S8GR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_52_3_1"/>
    <dbReference type="OMA" id="GGYKGSW"/>
    <dbReference type="OrthoDB" id="1907495at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10815">
        <property type="entry name" value="METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10815:SF13">
        <property type="entry name" value="METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding" evidence="13">
        <location>
            <begin position="44"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS23939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="151" mass="16041" checksum="1B1AC9AE5E340902" modified="2011-10-19" version="1">MTSRTNTRSLTQTTILPSTTVQSSSKPSSIPLPKPLQNSPLGTPFERSVWRLTAQIPPGSFSTYGILAAALKSSPRAVGNALKRNPFAPEIPCHRVLATGNMLGGFKGKIGHRDGDACASLQEKRALLQKEGVRFDALTGRALGTPFSGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYL8</accession>
    <name>G0RYL8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine rich repeat domain containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0007150</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS24004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691246.1">
        <property type="nucleotide sequence ID" value="XM_006691183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYL8"/>
    <dbReference type="GeneID" id="18254753"/>
    <dbReference type="KEGG" id="cthr:CTHT_0007150"/>
    <dbReference type="eggNOG" id="ENOG502S6PB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021422_1_0_1"/>
    <dbReference type="OMA" id="IFAPRIW"/>
    <dbReference type="OrthoDB" id="5213490at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="747"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="756"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS24004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="906" mass="99646" checksum="4F631BA59899015A" modified="2011-10-19" version="1">MANTYASDTPCLPSYQDAIARVDWLDLVAPYMNVKHYARLCRVSKRFYAQFAPRLWNDPVTVVCLLSRDPVDLDWLYVFLAHCIKRVRPETRALVRSLDLRPLLAAVSVAQFSVSMAGSSALLSRALSVFPSLACLLVDGHPDLDLASLAARPVSEDASGHPLLLLSIPRCQTELPAAFFASPLLRSLVYLDVSYLPGSLKTALAQKTLSPASLPYLRILKAQGREMDDATAALLFKVFGAQLWSVDLSRNRLTDAVFEDMDLCFAPVPCRKGDAGVEGSIMQHSALGTSMFGLFSHIWESKWSGTFNHPHRYLADAPGYSQDVHTNRLDGTVKIHDDSADAVKTLLSGGAGRHSPVLERIPGLVICQSPFGLTHLYLNGNSISAAALTKRMRMSPGLLQHLECDTPLFTIPEAARRRSWLASKEVKLWGILGEAHWFRSLVAPDLQVLRIHHSLVTQLLTLHIPYRLPMETLWLAETYLLPRAEMAYPQAFVPDMNPRLRSLTLTHIPRYSTGRLIEKLIAFLKLASLQERAVQDVRRSSSRRGPAVLSGLRHIRLEFQPDPRQTFEEDLNYDEELDFERSLTSFQEFSITDTLNWDSSLADEKPVAQRQVDPSPYGTCLPNTAPPASEPKETSPTQSVQLTPFYPYSIRENENKNTMRHTWTYHGRTVIAPVFIGDGHLRPSNHPALNEYMRLLASGDADLLADPEPASPCHVAAGVPGGAIVFGAAWKGILATLSDRNWSALPTPPLLPRGMSNSSSSGNTGSKSESLKAGLGGCASGDLSSCAVHGCEGCAGNNYTTPFLGQKTCSSTGSGPTENHQAYITPQSHVQFQSQVSSPRKAPKPTRAQLAQMRDVVAAIKAYRAQTRAAYEEEKRKAKAEGREILLGEPHFHWMGSLEVVVPVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYW8</accession>
    <name>G0RYW8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate dehydrogenase assembly factor 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0000850</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SDHAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690638.1">
        <property type="nucleotide sequence ID" value="XM_006690575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYW8"/>
    <dbReference type="GeneID" id="18254123"/>
    <dbReference type="KEGG" id="cthr:CTHT_0000850"/>
    <dbReference type="eggNOG" id="ENOG502S6UN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101052_0_1_1"/>
    <dbReference type="OMA" id="GGDWSYN"/>
    <dbReference type="OrthoDB" id="201362at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012875">
        <property type="entry name" value="SDHF4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524:SF3">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07896">
        <property type="entry name" value="DUF1674"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="54"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS23396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="159" mass="17083" checksum="03B31BE728788F20" modified="2011-10-19" version="1">MSRFLPLRPLRAPRPALTPIRPYSSSFLQNSPAPPRLPADQQAEFERLQRAAAATLNSHTSIPSSISIDPLATSRHVTTPSPGSNPQAQVQEPPTLHRAPSPVDFVTAGTFSGGIRGGAPPEFEGDKNPKTGEIGGPKNEPLRWGPEGDWSFNGRVTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZ14</accession>
    <name>G0RZ14_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0001350</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690684.1">
        <property type="nucleotide sequence ID" value="XM_006690621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZ14"/>
    <dbReference type="GeneID" id="18254173"/>
    <dbReference type="KEGG" id="cthr:CTHT_0001350"/>
    <dbReference type="eggNOG" id="ENOG502SJVT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007091_3_0_1"/>
    <dbReference type="OrthoDB" id="4337792at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF131">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="60"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="841"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="889"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="845"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="896"/>
            <end position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS23442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1251" mass="138194" checksum="0C2273C59104506F" modified="2011-10-19" version="1">MAEPQSDPKSARFRKRRAIVVCIVCRLRKLKCNREIPSSNCVRSKDVACLYYPEGLDALPNPQTSQTQSQPAALPEPPPPEPGPSTSSSSYPVPPFSGGQEHNNFGFAAPPLPPPSEHRPRRPGRPSNLTTRLPSLAAANAAIAPPSRSIPPEAPLQPPGERRKKRKAPQAEEQGESSAAAAAGRRRVGRQFVNVTFSPADEKGDGRVETTTVELAGFTEDIHFQSEQHSPGPGQQQRGFSQSVVHRRRFFGQSHWLNVMNLIQPLFQTLTTYLRASPSPIPSLSRRAKHLAKLIKARQVCDVLVTNYLRTYESIYRLLHIPSFQRAYDAVWGPEHTPDTVFVVQLKLVLAIGAATYDGMFSLRSWATKWVYEAGTWLGMPGNKGGVSLAGLQTSILLLLAKEATGVDEDMVWVGIGSVIRMAMCLGLHRDPTGLAIGPGPGGRESLYDVEMRRRLWNTVLEIAVQASLNSDGPPGIGLEDFNTKMPGNYNDEDLERDTAPKPETTFTQTSLAIALRRILPERLAIAKYLNNFSSKGVYAETLRHDTELRAASKALNQILQTYRSVPNGPSDLDLRMLDLLIRRYFPALHFPFFSSSLTDKSYAFSRKVVVESALRFRRAIFPSPLPSSNQHDPPDDTGDLLSRSAINGETFLSTVPLQSFICILAELQALIRESEDERFGLSGILPSLSVETIRPDLVSFLSEFKEFAWRAIRAGATNVKGYLVGCVGVAAIDAVKRQENKEEVVVRALEEGVRKCVRWLERCVEGGYTDPALEEDGDIDVQEGRWDGDWDLEQKTMVPNASQQTLFPPIQLQPGAQFPSSGDADQFQLLSDSFSNLTLSRDLPGSPQSFPSAPSSPSYILSSARPTATIQPGLESFQGGTGTGCTSRCDPICDQPPQRQHPSQQNQQEDHPIISIPPLLVPPGENVIFAHSSFFSQNAPLGISELPSPSQVRVQAAWLNLTPTFTSHYHSHHGYQEQSGNFDPVNCACYVYTVPFPQLGLVVRFGRGVNASSEGKTLLLVRGALKQAGIEGWEKVPECFGWRRDGREEKEVVCGEVERLVRAWRGLSWGIGKYFIGSIDRTPLCDTLFRSCGSSPSPAAGPFPSVSAFHDYLVQTALSNSQSRQGTLVAGSHSHHHYNPHHLFPPNVPITFTHSALHPRNILIFPSPHQPPKVVAILGWDQAGFYPSYWQTFKAKWECTLSNGIADWQGEWLPRVLDLEKVEGEVKRAGWSLSALAEYWGYWVRMIVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZ17</accession>
    <name>G0RZ17_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0001380</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690687.1">
        <property type="nucleotide sequence ID" value="XM_006690624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZ17"/>
    <dbReference type="GeneID" id="18254176"/>
    <dbReference type="KEGG" id="cthr:CTHT_0001380"/>
    <dbReference type="HOGENOM" id="CLU_1686362_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="156" mass="17780" checksum="A435CBB0FFC24B72" modified="2011-10-19" version="1">MCTWINLRYACGCHARKPWRVQACDGFAYYQPCTSTRRVHMTYEHGCDQHLGRFPHLHPPPRPASYWRELAQRQSEWNVIPMTREEFERRRAEKEAQGKGHGNATQQSGQGDDPQPIQLDASKQAKGVVQSPTQHGAKRPADSDGNAPERKKSQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZ49</accession>
    <name>G0RZ49_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative GTP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0001700</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690719.1">
        <property type="nucleotide sequence ID" value="XM_006690656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZ49"/>
    <dbReference type="STRING" id="759272.G0RZ49"/>
    <dbReference type="GeneID" id="18254208"/>
    <dbReference type="KEGG" id="cthr:CTHT_0001700"/>
    <dbReference type="eggNOG" id="KOG1547">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017718_7_1_1"/>
    <dbReference type="OMA" id="QCEFVYL"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032161">
        <property type="term" value="C:cleavage apparatus septin structure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005940">
        <property type="term" value="C:septin ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043934">
        <property type="term" value="P:sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cell division control 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="7">
        <location>
            <begin position="31"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="307"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS23477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="343" mass="39197" checksum="0CBD467A57AFB8CD" modified="2011-10-19" version="1">MASVPPPTIYPQSHVGFDSITSQIERKLLKRGFQFNIMCVGQTGLGKSTLINTIFASHLIDSKGRMAPDEEIRSTTEIQAVSHIIEENGVRLRLTIVDTPGYGDLINNDRCWDPIVKYIKDQHSAYLRKELTAQRERYIQDTRIHCCLFFIQPSGHSLKPIDIVVLKKLSDVVNVVPVIAKADSLTLEERQAFKERIREEFAFHNLKMYPYDNEELDEEERTLNNQIKSLIPFAVVGSEKTIIVNGKPVRGRQNRWGVVNVEDENHCEFVYLRNFLLRTHLQDLIETTSQIHYETFRAKQLLALKESSAGGHSSNNSRPISPSAGDRDREVSRSSQRQTMNGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZE8</accession>
    <name>G0RZE8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0002710</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTC36 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690818.1">
        <property type="nucleotide sequence ID" value="XM_006690755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZE8"/>
    <dbReference type="STRING" id="759272.G0RZE8"/>
    <dbReference type="GeneID" id="18254309"/>
    <dbReference type="KEGG" id="cthr:CTHT_0002710"/>
    <dbReference type="eggNOG" id="KOG4555">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074601_0_0_1"/>
    <dbReference type="OMA" id="ILYKAAR"/>
    <dbReference type="OrthoDB" id="539634at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006570">
        <property type="term" value="P:tyrosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038906">
        <property type="entry name" value="TTC36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21405">
        <property type="entry name" value="CDNA SEQUENCE BC021608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21405:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="267" mass="29701" checksum="09FC774FDE2FA796" modified="2011-10-19" version="1">MAYVNVELSRRDINVLEKIKDPESNPYLAPHIDPSLPKDPHFSDEEYQKLAQQERDIILSIQNLEIQHAKQQSADLTAITEGYRTCVSRLSDLIQAHPQYASARNNRAQALRRLYGDSVLISDAPRNPQTLLHDVSDVERIEAANTILGDLCEAISLVSPKVPYGSRVSPQVARTLSNAHTQRAAIYLMTSKLLGSEKSLSMDPARPESRWTKLDFETFASQDFAMGGRYGNEIAKGLAVSTNPTAKLCGQMVREAMKKEYGPDFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZJ8</accession>
    <name>G0RZJ8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">UDP-N-acetylglucosamine transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0003210</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690868.1">
        <property type="nucleotide sequence ID" value="XM_006690805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZJ8"/>
    <dbReference type="STRING" id="759272.G0RZJ8"/>
    <dbReference type="GeneID" id="18254359"/>
    <dbReference type="KEGG" id="cthr:CTHT_0003210"/>
    <dbReference type="eggNOG" id="KOG1583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033007_0_0_1"/>
    <dbReference type="OMA" id="NPFTGWH"/>
    <dbReference type="OrthoDB" id="999962at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005462">
        <property type="term" value="F:UDP-N-acetylglucosamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005464">
        <property type="term" value="F:UDP-xylose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF4">
        <property type="entry name" value="NUCLEOTIDE SUGAR TRANSPORTER SLC35B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS23626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="47045" checksum="D9CEA4096374DAFE" modified="2011-10-19" version="1">MKARRRLALHKHQQSPSNSHKERGEKAALAAAMMSAAPSPRVINAAPSLEKAEMYGIDDNRPVFSRAMALAGRMFIETIPQWLAIGAMLSLIFGGCCSNVFALESIIKVEPASGTLLTFVQFLFVAAIGLPEQFDPKRPPFFLKPNKVPIRRWLVNIILFFSINVLNNHAFSYDISVPVHIILRSGGSITTMIAGSLYGKRYSRIQIVAVILLTVGVITAAWSDAQTKGTPTADKPSSAASFGTGLAILFIAQVLSAIMGLYTEETYRRYGPQWKENLFYSHLLSLPLFLPFLPSLTKQFMKLANSAPLQLPTPQLSLEEYPNLAPSIQRAIERIKIPNQLFYLALNVLTQYACIRGVNLLAAASSALTVTIVLNIRKLVSLLLSIWLFGNRLAFGTLVGAVIVFFAGGLYSLDGKRKPPMRRVAPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZL9</accession>
    <name>G0RZL9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Small-subunit processome Utp12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0003430</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2016" name="Nucleic Acids Res." volume="44" first="7475" last="7486">
            <title>Integrative structural analysis of the UTPB complex, an early assembly factor for eukaryotic small ribosomal subunits.</title>
            <authorList>
                <person name="Zhang C."/>
                <person name="Sun Q."/>
                <person name="Chen R."/>
                <person name="Chen X."/>
                <person name="Lin J."/>
                <person name="Ye K."/>
            </authorList>
            <dbReference type="PubMed" id="27330138"/>
            <dbReference type="DOI" id="10.1093/nar/gkw562"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (3.51 ANGSTROMS) OF 769-931</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="journal article" date="2017" name="Nat. Struct. Mol. Biol." volume="24" first="954" last="964">
            <title>3.2-A-resolution structure of the 90S preribosome before A1 pre-rRNA cleavage.</title>
            <authorList>
                <person name="Cheng J."/>
                <person name="Kellner N."/>
                <person name="Berninghausen O."/>
                <person name="Hurt E."/>
                <person name="Beckmann R."/>
            </authorList>
            <dbReference type="PubMed" id="28967883"/>
            <dbReference type="DOI" id="10.1038/nsmb.3476"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.20 ANGSTROMS)</scope>
    </reference>
    <reference evidence="14 15 16" key="4">
        <citation type="journal article" date="2019" name="Mol. Cell" volume="75" first="1256" last="1269.e7">
            <title>Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration.</title>
            <authorList>
                <person name="Cheng J."/>
                <person name="Bassler J."/>
                <person name="Fischer P."/>
                <person name="Lau B."/>
                <person name="Kellner N."/>
                <person name="Kunze R."/>
                <person name="Griesel S."/>
                <person name="Kallas M."/>
                <person name="Berninghausen O."/>
                <person name="Strauss D."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="31378463"/>
            <dbReference type="DOI" id="10.1016/j.molcel.2019.06.032"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.50 ANGSTROMS)</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat WDR3/UTP12 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690889.1">
        <property type="nucleotide sequence ID" value="XM_006690826.1"/>
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    <dbReference type="PDB" id="5IC9">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.70 A"/>
        <property type="chains" value="A/C=748-956"/>
    </dbReference>
    <dbReference type="PDB" id="5ICA">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.51 A"/>
        <property type="chains" value="A=769-931"/>
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    <dbReference type="PDB" id="5OQL">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="I=1-962"/>
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    <dbReference type="PDB" id="6RXT">
        <property type="method" value="EM"/>
        <property type="resolution" value="7.00 A"/>
        <property type="chains" value="UL=1-962"/>
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        <property type="resolution" value="3.50 A"/>
        <property type="chains" value="UL=1-962"/>
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        <property type="resolution" value="4.00 A"/>
        <property type="chains" value="UL=1-962"/>
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        <property type="resolution" value="7.10 A"/>
        <property type="chains" value="UL=1-962"/>
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        <property type="method" value="EM"/>
        <property type="resolution" value="4.70 A"/>
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        <property type="method" value="EM"/>
        <property type="resolution" value="4.40 A"/>
        <property type="chains" value="UL=1-962"/>
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    <dbReference type="PDBsum" id="5IC9"/>
    <dbReference type="PDBsum" id="5ICA"/>
    <dbReference type="PDBsum" id="5OQL"/>
    <dbReference type="PDBsum" id="6RXT"/>
    <dbReference type="PDBsum" id="6RXU"/>
    <dbReference type="PDBsum" id="6RXV"/>
    <dbReference type="PDBsum" id="6RXX"/>
    <dbReference type="PDBsum" id="6RXY"/>
    <dbReference type="PDBsum" id="6RXZ"/>
    <dbReference type="AlphaFoldDB" id="G0RZL9"/>
    <dbReference type="EMDB" id="EMD-10051"/>
    <dbReference type="EMDB" id="EMD-10052"/>
    <dbReference type="EMDB" id="EMD-10053"/>
    <dbReference type="EMDB" id="EMD-10054"/>
    <dbReference type="EMDB" id="EMD-10055"/>
    <dbReference type="EMDB" id="EMD-10056"/>
    <dbReference type="EMDB" id="EMD-3847"/>
    <dbReference type="SMR" id="G0RZL9"/>
    <dbReference type="IntAct" id="G0RZL9">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0RZL9"/>
    <dbReference type="GeneID" id="18254381"/>
    <dbReference type="KEGG" id="cthr:CTHT_0003430"/>
    <dbReference type="eggNOG" id="KOG0306">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005318_0_1_1"/>
    <dbReference type="OMA" id="MNIPLTC"/>
    <dbReference type="OrthoDB" id="407922at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
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    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000157">
        <property type="entry name" value="WD repeat domain 3"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="2.130.10.10:FF:000178">
        <property type="entry name" value="WD repeat domain 3"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="5"/>
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    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
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    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
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    <dbReference type="InterPro" id="IPR051570">
        <property type="entry name" value="TBC1_cilium_biogenesis"/>
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    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
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    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
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    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
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    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN 3 WDR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF25173">
        <property type="entry name" value="Beta-prop_WDR3_1st"/>
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    <dbReference type="Pfam" id="PF25172">
        <property type="entry name" value="Beta-prop_WDR3_2nd"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
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    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="11 12 13" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="106"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="170"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="422"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="511"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="603"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="645"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="692"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="8">
        <location>
            <begin position="827"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="318"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS23647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
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    <evidence type="ECO:0007829" key="11">
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    </evidence>
    <evidence type="ECO:0007829" key="12">
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    </evidence>
    <evidence type="ECO:0007829" key="13">
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    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="6RXT"/>
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    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="6RXU"/>
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    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="6RXV"/>
        </source>
    </evidence>
    <sequence length="962" mass="107424" checksum="C2F481FF4BC26982" modified="2011-10-19" version="1">MVKSYLKFEPSKSFGVVVSSNSNLVWSSRGKAGAGAGQAIVAANEEVLVWDIKKGELLSRWRDENCKFRVTAIAQSRTDPDVFAVGYEDGSIRLWDSKIATSVVSFNGHKSAITVLAFDKTGVRLASGSKDTDIIVWDLVAEVGQYKLRGHKDQVTGLYFIEPDPVVRTEGEDDHAVMAVDSEPSDGFLLTTGKDSLIKLWDLSSRHCIETHVAQANGECWALGVSPDFTGCITAGNDGEITVWALDADALASSAQKVDLSQSVNFLQNRGTLHRSSKERAAEVVFHPLRDYFAVHGVEKSVEIWRIRNEAEIKKTLARKKKRRREKLKEKKAEGADADMDETDDTDIAKAEVSDVFVQHVIVRTTGKVRSVDWALNPGVKDLQLLVGGTNNLLELYNIVGKERLKSKGEEPDYNKALAVELPGHRTDIRSVAISSDDKMLASAANGSLKIWNIKTQQCIRTFDCGYALCCAFLPGDKVVIVGTKEGELQLYDVASASLLETVNAHDGHAVWALQVHPDGRSVVSGGADKTAKFWDFKIVQEPVLGTTRTTHRLKLVQSRILKVSDDILSLRFSPDARLLAVALLDSTVKVFFNDTLKLYLNLYGHKLPVLSMDISYDSKLIVTSSADKNIRIWGLDFGDCHKALFGHQDSILQVAFIPHNSDGNGHYFFSASKDRTIKYWDADKFEQIQRIDGHHGEIWALAVSHSGRFLVSASHDKSIRVWEETDEQIFLEEEREKELEELYEQTLTTSLEQDPDEQDANREIAAATKQTVETLMAGERIAEALELGMTDLNTIREWEEARQINPNIAPPQRNPIFVALGNIPAETYVLNTLQKIKPASLHDALLVLPFSTIPSLLTFLNLFAQRELNVPLTCRILFFVLKTHHKQIVASRTMRATLEKVRANLRAALRRQKDEMGFNIAALKVVSMQLRDKSVREYVDETWEEKEKEKGVRKRAFASLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0S057</accession>
    <name>G0S057_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Intracellular protein transport-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0008820</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691409.1">
        <property type="nucleotide sequence ID" value="XM_006691346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S057"/>
    <dbReference type="STRING" id="759272.G0S057"/>
    <dbReference type="GeneID" id="18254920"/>
    <dbReference type="KEGG" id="cthr:CTHT_0008820"/>
    <dbReference type="eggNOG" id="KOG0946">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006318_4_0_1"/>
    <dbReference type="OMA" id="GQETFCN"/>
    <dbReference type="OrthoDB" id="198977at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048211">
        <property type="term" value="P:Golgi vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000296">
        <property type="entry name" value="Related to transport protein USO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006955">
        <property type="entry name" value="Uso1_p115_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024095">
        <property type="entry name" value="Vesicle_P115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006953">
        <property type="entry name" value="Vesicle_Uso1_P115_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013:SF0">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04871">
        <property type="entry name" value="Uso1_p115_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04869">
        <property type="entry name" value="Uso1_p115_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vesicle tethering protein Uso1/P115-like head" evidence="5">
        <location>
            <begin position="359"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="Uso1/p115-like vesicle tethering protein C-terminal" evidence="6">
        <location>
            <begin position="909"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="951"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1012"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="951"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1018"/>
            <end position="1044"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS23218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1044" mass="116530" checksum="6483550F4908BA4F" modified="2011-10-19" version="1">MSMFSSITTAPAKQSVSETIPILSNRLATATLLEDRRAAILGLRSFAKQYPASVASTALRSLISSLSRDGEDVDTVKVVLETLLMLFTPDPSSPEASEEIALWVADEFTQRHENISMLLGFLAPDRTDFYSRLYSLQLLAAILEARTERTEECIISTNEGIPRIVAALEDPREAIRDEAVGLLTDLTPTSTVIQNLVTLEKGFTPIFAIITREGGLAGGARVVEDCLVLLGNLLRMNPQNQTMFRDMGFVSEVARLLREAYAASEEGQPIAEWVEVQRNRNVFALLAVLRLFLVPGAAGTPLNQEAFLGDLGAPSGRGRGGKSVGSVLDSTLQIGFSRVADMPIRAEALMACADMIRGNAKLQERFAALQVTSPLDFPPEAGDARVNGAIPKVYVIDGLLDMVLGVSSLQAFDLRMAACACLKAYFYKHAEIRMHFLDHAVRTHKMRADDLTNALSILLQPGLESVVDPYRIWFAAVLILHLLHENPETKALAMSITEGDEENGEEVVTSIQTIAAHLLSSVSKNLDPRISIAYLMLLLCWLFEDLDAVNDFLGEATNLQGLIQAAIENPNGDVVVQGLSAMLAGVVYEFSTKDSPVPRATVREMIMSRMGRDRYVDKMSRLRSHPLMREFEVLPQKLEDNGIDLKPPEVFFDETFVEFFKDNYSRILRAIDRDPDAETSVIINGVQKGVSRQLVDDLRAELSEKSQALQDAESKLSSLTEQLAQEQKSHQHAVQNAQDELARAADAANALRAQLAARDAQLQSASDQTATLTRQLAALQQEYQRAQAEIVRLKAAADAQQRAHAAELKSVTENLQRSHDKQLAQLKTEHKSREDELTREMAQLKIEHKSRQEELTRAMEAVKKAVEQESERAKRRWEAESADLRATISRLEVEVMKVGKERQRGDERIKELEQAVQDAESRFDDAEKKLKKKTEEVKRLEGVEARLKELEAKLKEADEERGRLEAEVERRKKEKEEKEKEKKEVQGELDDLLMVFGDLEEKVTKYKERLKALGQEVSDGEEEGEEEEDEDEDQDDEESSNEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0V8</accession>
    <name>G0S0V8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCD97-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0011410</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691660.1">
        <property type="nucleotide sequence ID" value="XM_006691597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0V8"/>
    <dbReference type="STRING" id="759272.G0S0V8"/>
    <dbReference type="GeneID" id="18255179"/>
    <dbReference type="KEGG" id="cthr:CTHT_0011410"/>
    <dbReference type="eggNOG" id="ENOG502SFGZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1618810_0_0_1"/>
    <dbReference type="OrthoDB" id="333176at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040233">
        <property type="entry name" value="CCD97-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018613">
        <property type="entry name" value="Ccdc97-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31840">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31840:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09747">
        <property type="entry name" value="CCD97-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCD97-like C-terminal" evidence="2">
        <location>
            <begin position="15"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="164" mass="18256" checksum="6B6BA21D0BF0DE43" modified="2011-10-19" version="1">MARLRAQTVQEERERARQQQQEQGQGTGVDGVRVTGETAPKHTFPPNGGHARAGPSANTNGMGDDDIPGTTLSSLNADLLPPPTNKEEGRAQWEEFLRDRFIRGEDDDFDYSLIDDNDEYDVLERQEQEEAWFDEEEPEWASSCGEEGEGGGRVLKGETGVQDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0X3</accession>
    <name>G0S0X3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sorting nexin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0011560</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="eabf8598" last="eabf8598">
            <title>Architecture and mechanism of metazoan retromer:SNX3 tubular coat assembly.</title>
            <authorList>
                <person name="Leneva N."/>
                <person name="Kovtun O."/>
                <person name="Morado D.R."/>
                <person name="Briggs J.A.G."/>
                <person name="Owen D.J."/>
            </authorList>
            <dbReference type="PubMed" id="33762348"/>
            <dbReference type="DOI" id="10.1126/sciadv.abf8598"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (9.20 ANGSTROMS) OF 71-186</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Prevacuolar compartment membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691675.1">
        <property type="nucleotide sequence ID" value="XM_006691612.1"/>
    </dbReference>
    <dbReference type="PDB" id="7BLQ">
        <property type="method" value="EM"/>
        <property type="resolution" value="9.20 A"/>
        <property type="chains" value="G/L=71-186"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0X3"/>
    <dbReference type="EMDB" id="EMD-12224"/>
    <dbReference type="SMR" id="G0S0X3"/>
    <dbReference type="STRING" id="759272.G0S0X3"/>
    <dbReference type="GeneID" id="18255194"/>
    <dbReference type="KEGG" id="cthr:CTHT_0011560"/>
    <dbReference type="eggNOG" id="KOG2527">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057172_2_0_1"/>
    <dbReference type="OMA" id="NMYTDYE"/>
    <dbReference type="OrthoDB" id="5227681at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034499">
        <property type="term" value="P:late endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07295">
        <property type="entry name" value="PX_Grd19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000030">
        <property type="entry name" value="Sorting nexin-3, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042138">
        <property type="entry name" value="PX_Grd19_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051074">
        <property type="entry name" value="Sorting_Nexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963:SF2">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="17" id="KW-0002">3D-structure</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="14">
        <location>
            <begin position="74"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS22683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PDB" id="7BLQ"/>
        </source>
    </evidence>
    <sequence length="195" mass="22152" checksum="93E6710B097C8AF9" modified="2011-10-19" version="1">MSSPQSYDTATAVPGAEDQQQTTQQPQSPPKSPSSTDKRALAAAAAARLHRPIMPTLPESRPQTFDEIYGPPENFLEIEVRNPQTHGVGRHMYTDYEIVCRTNIPAFKLRQSSVRRRYSDFEYFRDILERESARVTIPPLPGKVFTNRFSDEVIENRRAGLEKFLKIVVGHPLLQTGSKVLAAFVQDPNWDRNAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0S144</accession>
    <name>G0S144_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0012290</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691746.1">
        <property type="nucleotide sequence ID" value="XM_006691683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S144"/>
    <dbReference type="STRING" id="759272.G0S144"/>
    <dbReference type="GeneID" id="18255267"/>
    <dbReference type="KEGG" id="cthr:CTHT_0012290"/>
    <dbReference type="eggNOG" id="KOG3801">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011335_1_0_1"/>
    <dbReference type="OrthoDB" id="2399539at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990221">
        <property type="term" value="C:L-cysteine desulfurase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20264">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045297">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051522">
        <property type="entry name" value="ISC_assembly_LYR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166:SF7">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166">
        <property type="entry name" value="PROTEIN C6ORF149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="3">
        <location>
            <begin position="558"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="349"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="631"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="637"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS22754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="652" mass="71763" checksum="732B2F5F6BAE4371" modified="2011-10-19" version="1">MDVDNNPSGPSVPLTVPPPPGQSPDQLQPGGTHPPVIIRRRAPIACRRSDKSKKRDVTKMKSVDESIPVRLPVPAAPSQVKGGDEWDLLPPLLEVLDAVNTFTRHYFQLGFIPKQLFPERLQANPRSVSVFFLLGILSVSARLTPALVRRYGSAVKASEIFMERASALAQTEVYKEPSLERCQAFYLLSIAQQGSGLKYQSSINMAISIRMATLMQLHREETYVLQNPTRELIIRAESARRTLAYLGVTMIPRLCNIVLRKAYLQEMLSDNKSDPTLTSFWNKMAHELFQNVEDLYQQIETQFSERPSEEGPGAQMAIPAQTVWPLASRWYEHLERFYKTQSVVPVGAEGGMDDSRDPIPHVLQQAPKGQDMRSGSQTSISPIPGRDGQPASNPAVTIAPLSTPPVVSTSYAGAAGIAPPTSVAQAQTVPQPLPPQQHMLPSHSQVEVTPATVPVPQGPAAPRPPTTDGLGLLLEAFDTHQAASGAAAPPNVVVAGPTTITTVPQPPHSQHQAQATFSPHVPTQQQQAYFPPQTQPQPNPHATGLVMNDGQVGLEGEYRQLLRQGRQFTNYNFREYAKRRTRDAFRENKDVQDPAQIQELIQKGRQNLDMMKRQVAISQFYQLNKLVVEGGLSGKDSPGHGETVRQKDTGWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0S160</accession>
    <name>G0S160_CHATD</name>
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        <recommendedName>
            <fullName evidence="2">Transcription elongation factor Eaf N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0012450</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691762.1">
        <property type="nucleotide sequence ID" value="XM_006691699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S160"/>
    <dbReference type="STRING" id="759272.G0S160"/>
    <dbReference type="GeneID" id="18255283"/>
    <dbReference type="KEGG" id="cthr:CTHT_0012450"/>
    <dbReference type="eggNOG" id="ENOG502SEGQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041956_0_0_1"/>
    <dbReference type="OMA" id="VDSTFHM"/>
    <dbReference type="OrthoDB" id="125903at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019194">
        <property type="entry name" value="Tscrpt_elong_fac_Eaf_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09816">
        <property type="entry name" value="EAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription elongation factor Eaf N-terminal" evidence="2">
        <location>
            <begin position="15"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="374" mass="41525" checksum="6BFB22B788C2B3C6" modified="2011-10-19" version="1">MAAPVTIDPTKPGRYPIILSDALLGKPSKELYTAVRYNYRPTLSSETAPNAARIKQSGRDDSYNLGFDDQGNKYQYNGVRTTGDGNYILIFDPARQAFVLHRVDSTFHMNVTRTPTEGNVEALRKQFPQLEVKNGNEVKQQKGKGAARAGASKAASTKAKAGAAAVDEAKSKESEKAKPVTLSFPDLNASPKSQPATQEQQEKTEPPPPPKRRAVSPIESEEEDDDDDGGLTVEYPDGEPVKYVTTNYPITLTRRFSEFARDHENEEDEESNNSYDRGGYNMYGGYDADEAGYEEEEEEEEEEEEVRPPPPPPPKPQSPEVPPATEPERYTFDEGDEDGEGEEDPDFGDLEADLEREFNKVQAEVDESDVSEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1R5</accession>
    <name>G0S1R5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED17</name>
        <name evidence="10" type="ORF">CTHT_0014540</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Mol. Cell" volume="81" first="1781" last="1788.e4">
            <title>Mediator structure and conformation change.</title>
            <authorList>
                <person name="Zhang H."/>
                <person name="Chen D.H."/>
                <person name="Mattoo R.U.H."/>
                <person name="Bushnell D.A."/>
                <person name="Wang Y."/>
                <person name="Yuan C."/>
                <person name="Wang L."/>
                <person name="Wang C."/>
                <person name="Davis R.E."/>
                <person name="Nie Y."/>
                <person name="Kornberg R.D."/>
            </authorList>
            <dbReference type="PubMed" id="33571424"/>
            <dbReference type="DOI" id="10.1016/j.molcel.2021.01.022"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (4.20 ANGSTROMS)</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 17 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691967.1">
        <property type="nucleotide sequence ID" value="XM_006691904.1"/>
    </dbReference>
    <dbReference type="PDB" id="6XP5">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.20 A"/>
        <property type="chains" value="Q=1-634"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1R5"/>
    <dbReference type="EMDB" id="EMD-22284"/>
    <dbReference type="SMR" id="G0S1R5"/>
    <dbReference type="STRING" id="759272.G0S1R5"/>
    <dbReference type="GeneID" id="18255492"/>
    <dbReference type="KEGG" id="cthr:CTHT_0014540"/>
    <dbReference type="eggNOG" id="ENOG502QS9H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015164_0_0_1"/>
    <dbReference type="OMA" id="AAETKYW"/>
    <dbReference type="OrthoDB" id="5319830at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019313">
        <property type="entry name" value="Mediator_Med17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114:SF7">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10156">
        <property type="entry name" value="Med17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="12" id="KW-0002">3D-structure</keyword>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS22975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="6XP5"/>
        </source>
    </evidence>
    <sequence length="634" mass="69538" checksum="BE4500A8B5D80E76" modified="2011-10-19" version="1">MTDRPFILQVPPTQQRGPQNIAEFVARINPDAFRVLNEAELRRKVEEEKNGVGQDEDVDMESSPSDNEGEPADAKDIITAKHEMLRVIDQTRQTTLYALDFVSLLLSKENPGQAVTTFSPGLRELVGIGTLGATMLDAPTPLTQSRIPDNKLVTIGKRLMDLNKAADTALAASKRLQKEIAAETKYWSEVLAVRNDGWQTSRMPREPQTMGVKFGFNNAAPEFKAVSIAPMRRADNGSVLLDRSSIGHKSQRIQVRILEDGRIVGRSSLPSPVSADAPLQDRVKEMRDTIFAQELWHEINREARTLLNQGVHLEPSSITYTMDASTTVSIRLATLGEEEEGLDEQQEGPQDVMAESLNIALSLLLSHAHRMNELRRSEPGINKGPPRTYPILLPLISYHKYNQSIQTCLQTLSAHISVLRSASVDSSMTVKEPLLSSPPGAPAATSLYTILTRPPAVQFDITITPDSRIRILLKPTQLTGAAFSICCLPALHPGAQNPLATTCPPSTDDYDSLTQVVSYLQAAIPRALAAHYEAVLVVEATVNGGMLGDLPPSPSRWMPLIDGKGIVDPETMRFGIRFSFGRNPAKGGQLELGAQTDYVDGSRKRVRRNWIWPGAQSSLDSVAKHVLARGPPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1R9</accession>
    <name>G0S1R9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein YIF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0014580</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Has a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Golgi apparatus membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the YIF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691971.1">
        <property type="nucleotide sequence ID" value="XM_006691908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1R9"/>
    <dbReference type="STRING" id="759272.G0S1R9"/>
    <dbReference type="GeneID" id="18255496"/>
    <dbReference type="KEGG" id="cthr:CTHT_0014580"/>
    <dbReference type="eggNOG" id="KOG3094">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047877_2_0_1"/>
    <dbReference type="OMA" id="SGYKFVH"/>
    <dbReference type="OrthoDB" id="337750at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005578">
        <property type="entry name" value="Yif1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083">
        <property type="entry name" value="YIP1 INTERACTING FACTOR HOMOLOG YIF1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083:SF0">
        <property type="entry name" value="YIP1D-INTERACTING FACTOR 1, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03878">
        <property type="entry name" value="YIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="307"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS22979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="326" mass="37070" checksum="A007B52C599D0E96" modified="2011-10-19" version="1">MQRPTYSHSPPLHHPVPQHVSTVPQLRSPPPLASSYDGSPYQPQPQHQAPSGTGMFGPYANFINDPAAQIATQFGQSAFRHGQEYFEQNVNRFVNVTALKHYFNVTNSYVLSKLFLVLFPWRHKPWTRRQAPGGGGRPGQENWYYLPPRDDINSPDMYIPVMSLVTYIFLQALISGLRGKFQPELFGYIATTAVVVQIVEILGLKLGCYLLSISNESQLLDLVAYSGYKFVGINVTIIIAEIVNGGKGTGGWVGWMVFLYTFLANSLFLMRSLKYVLLPENNNDRGNPMQTMHPLDSRAKRNQRTQFLFFYSYIVQLFFMWILCRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G0S239</accession>
    <name>G0S239_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">tRNA (uracil(54)-C(5))-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0015880</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNA. May also have a role in tRNA stabilization or maturation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>uridine(54) in tRNA + S-adenosyl-L-methionine = 5-methyluridine(54) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42712"/>
            <dbReference type="Rhea" id="RHEA-COMP:10167"/>
            <dbReference type="Rhea" id="RHEA-COMP:10193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74447"/>
            <dbReference type="EC" id="2.1.1.35"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.35" evidence="5"/>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS23099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692091.1">
        <property type="nucleotide sequence ID" value="XM_006692028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S239"/>
    <dbReference type="SMR" id="G0S239"/>
    <dbReference type="STRING" id="759272.G0S239"/>
    <dbReference type="GeneID" id="18255626"/>
    <dbReference type="KEGG" id="cthr:CTHT_0015880"/>
    <dbReference type="eggNOG" id="KOG2187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014689_3_1_1"/>
    <dbReference type="OMA" id="GGCKWQH"/>
    <dbReference type="OrthoDB" id="10250660at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030697">
        <property type="term" value="F:tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000201">
        <property type="entry name" value="TRM2p tRNA methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000174">
        <property type="entry name" value="TRM2p tRNA methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025795">
        <property type="entry name" value="tRNA_(uracil-5-)_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="RNA M5U METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061:SF30">
        <property type="entry name" value="TRNA (URACIL(54)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51622">
        <property type="entry name" value="SAM_MT_RNA_M5U_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 9 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 9 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TRAM" evidence="12">
        <location>
            <begin position="91"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="493"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="493"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00070108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS23099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="544" mass="60047" checksum="F4A6AE26CB9497E6" modified="2011-10-19" version="1">MSSNGTEAAIQAQAESNPHKRPLQNSPHGKQAQKPSKRQRKKDKKHIVQEGSHEEILLTDVQNLLASLKASDDAAPTEDGVSETTTQETALPELGTELELEVVELSSTGDGLARRKGVPDEKHVYVVPFSIPGDVVKARVVRHHLEEGYTAADFLSVIAPAPYRDDARIQCQYFGRCPGCQFQMLSYDHQLRIKREIIVKAYKNFSELPPELVPTIGETIGSPLQYGYRTKLTPHFDGPPGMFRKNVPKKPLQACPPIGFTPKHSRTVLDIEDCPIATEAVSEGVDCRAGENEDGSSPNENPAVPAEVECQPGRAKDVLVRIDTPSHVDFKTCITDQKAPATEWIDNFRFTSPAGTFFQNNNSILSPFTAYIREHILPPPAEGQKPIRYLIDAYSGSGLFTITQSSLFPGGSIGIDISEGSILYARRNAAANDLPESRCRFVAADANELFKSVSEYDPDETVVVLDPPRKGCDGNFLRQLLRYGPRRVVYVSCNVHTQARDVGVLVRGVEGVKRRYTVESIRGFDFFPQTGHVESVAVLNRVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G0S295</accession>
    <name>G0S295_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CTHT_0016440</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination. Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692147.1">
        <property type="nucleotide sequence ID" value="XM_006692084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S295"/>
    <dbReference type="STRING" id="759272.G0S295"/>
    <dbReference type="GeneID" id="18255682"/>
    <dbReference type="KEGG" id="cthr:CTHT_0016440"/>
    <dbReference type="eggNOG" id="KOG2747">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011815_0_0_1"/>
    <dbReference type="OMA" id="WIAPDDC"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046972">
        <property type="term" value="F:histone H4K16 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000067">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF219">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="16">
        <location>
            <begin position="212"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="250"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGS22128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="718" mass="76851" checksum="50F47F77D8595BD5" modified="2011-10-19" version="1">MPAHLKRKCPAKEEDEEVHARRPAPAARAPAVTAAPEGPLRRATRASSIPPVQAPADPEPRRRRRNIDANAQVPKSPRGKENIPEQPQPQQPQQPQLKPARATRACRAPSPVSVSASAGGSSQARAAPKPRPAPRDSDSSSSAPAPTATSRWSSQQRVAGPSMLPQQQQSGSVSRSTHMFTTAPTAPPSSAAAAVNGASGGQASTAGSVEARSDRNIDKVVLGNICFRAWYPSYYGKEVLGDLSAGGKGTKNNSSNTNGANGHSGSKNNGPNGGKTHGRRGADNSQPILDRLYVCPCCFKYSKELVAWWEHVQICERKGFIPGTKIYTHPKGKRTVLVPAGPAPKQGRGRRAANAYPKLVEQEVHDEGEWSVWEVDGEEDTLFCQNLSLFAKLFLDTKSVFFNVTDFKYYLLVYTPPSRPANPDTPNAKLIQPRGQIVGFFSKEKLSWDQNNLACILIFPPWQRKGLGSLLMGISYEISRREGLIGGPEKPISDLGKKGYKRFWAGEIARWLLSLPSQQQQQQRAATAPSPDADADPVALPVGPAYGDGDKFLITITDISQATWIAPDDCLAVLREMGVAEDAGMGPAPAPRRYYHHHAAPHAAVVGADDDTVPVAASVGPASASASLSSCPASATGTSAAATSVPHFNGGPAENMMMTSSTTPREVPRVKISLGAVRAWIEKHRINLERTCDPGGFIEGYGWAKKDKDVVVGGTEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2E4</accession>
    <name>G0S2E4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative NGG1 interacting factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0016940</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692196.1">
        <property type="nucleotide sequence ID" value="XM_006692133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2E4"/>
    <dbReference type="STRING" id="759272.G0S2E4"/>
    <dbReference type="GeneID" id="18255732"/>
    <dbReference type="KEGG" id="cthr:CTHT_0016940"/>
    <dbReference type="eggNOG" id="KOG4131">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037423_0_1_1"/>
    <dbReference type="OMA" id="NFDKTHL"/>
    <dbReference type="OrthoDB" id="3345469at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1390.30:FF:000001">
        <property type="entry name" value="GTP cyclohydrolase 1 type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.30">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00486">
        <property type="entry name" value="YbgI_SA1388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="NGG1 INTERACTING FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799:SF13">
        <property type="entry name" value="NIF3-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="DUF34_NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602678-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="295" mass="32023" checksum="226971F5605CCA85" modified="2011-10-19" version="1">MASVSSPAFTQRVVQAMRSLYPEELADRAWDNVGLLQDNVAPASGDVPRRVLLTNDLTERVAEEAVKKGVSVIVSYHPFIFRGLKSITTNEPHQRIILRLAQANIAVYSPHTAVDAAPSGLNDWLADILPSHNIPLSSRSIAQPLRTPAPPGFEQSGYGRLLTLSQPTSLSSIVKAYASGLGSFRHVIVSPPHNASDPKEALIRSVAVCAGSGADVFKDVDADCYVTGEMSHHVALRLGMLGKAVVMVLHSNSERGYLKGVMKPRLEELLKEEGAEVIVSEEDRDPFEIWDVSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2E9</accession>
    <name>G0S2E9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0016990</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692201.1">
        <property type="nucleotide sequence ID" value="XM_006692138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2E9"/>
    <dbReference type="GeneID" id="18255737"/>
    <dbReference type="KEGG" id="cthr:CTHT_0016990"/>
    <dbReference type="HOGENOM" id="CLU_2183654_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="109" mass="12092" checksum="C8DE76C775C79A9B" modified="2011-10-19" version="1">MVPSSAGVLAAFRRARDQKVRELKATMSVVEKLLSALKDVERNLTGNYERKVGKQIITKLHSFIQVSMTDGPQPSSPVVYHWNGLKPGAEQSTCETAQEASYRSIKTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2F1</accession>
    <name>G0S2F1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0017010</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692203.1">
        <property type="nucleotide sequence ID" value="XM_006692140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2F1"/>
    <dbReference type="GeneID" id="18255739"/>
    <dbReference type="KEGG" id="cthr:CTHT_0017010"/>
    <dbReference type="HOGENOM" id="CLU_440748_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="364"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="461"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="620" mass="70557" checksum="C75195E02745A897" modified="2011-10-19" version="1">MTDDATSDPLTPTTDPKYEHHPRPMMDDITEPLNNNNNNNNNNNSHALPADLCESNDGNNDNVLKALQRLSAKLNTNPPNIPFLSIHPEARYDCPQPPSATADLSDKEKDIVTSTSQDVSIAELFHEIKRLEQEVRSYGKKVDSLNFKIELLKQENDTRWERVGMGQKQEEKLAKVGEIAKTCDRNSWSSSNSNSNSDSDSDSGSETTESRTERPVREGLNNINMEMGISKGEDWKREELRKRLEELRGEWVRRKEEEEDKKKKHYISEVNKGRVIISEQVRGVRKKKEWSTRLTVGEPSWELWAEEHVWDARTRGPSQEGDTGMKGSLGELKWCAASAGNGGEEEDVHSRKRKVRFVDEENGHGLLGSKQFDYERTSGEGGQMSGNDVTPSNKDDRAFSEQTHIDIEEHDDAETPEEDQFSREELTALRKENTQLKAEIGDLWVQVCKETEETRQWRDWAQWLEEENARLQEENNQLSLELDEERREGIVDCIVNSLLDLFFGSSSSLDAAQTHEQGQNAGRRTLSLENPGVAEMLRVTVATRTAFQGGIEVGGEWWLRMGPTYQWCVERGVGLLSWAWPKPEGTLQKRHVGYGLEDWSWPGSSMEAVQSLGDEEQEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2U1</accession>
    <name>G0S2U1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0018480</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692343.1">
        <property type="nucleotide sequence ID" value="XM_006692280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2U1"/>
    <dbReference type="GeneID" id="18255886"/>
    <dbReference type="KEGG" id="cthr:CTHT_0018480"/>
    <dbReference type="eggNOG" id="ENOG502QU2M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1142485_0_0_1"/>
    <dbReference type="OrthoDB" id="5395440at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="122"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="243" mass="28013" checksum="AD409FFFCD3EB02F" modified="2011-10-19" version="1">MQQELEQLRSEQAERERLIADTAKLQKEIEALRAECAEHARRAQEASRLQHELQMLRSENAELKMSTSIGSPPPPPTRMSMGLSRALKSLLERQGPQNRENAKRIRQLEMERDRLLSASPKKAGYEHEVTKLRDEINVLRRRAEEAIEQKFQVEKGPIGLKMDLDRAQEEIASLRRLLEEKAILIPNAWDRPSSSYSEKEENEQVHPSGPSLRLRSRRHTRTCTPPILMLLGASRAWKSLFAK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-06-24" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2X1</accession>
    <accession>G0ZGV1</accession>
    <name>NUP37_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleoporin NUP37</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Nuclear pore protein NUP37</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">NUP37</name>
        <name type="ORF">CTHT_0018790</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1 6">The nuclear pore complex (NPC) constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. The 55-60 MDa NPC is composed of at least 28 different subunits: AMO1, ELYS, GLE1, GLE2, MLP1, NDC1, NIC96, NSP1, NUP133, NUP145, NUP152, NUP159, NUP170, NUP188, NUP192, NUP37, NUP49, NUP53, NUP56, NUP57, NUP82, NUP84, NUP85, POM152, POM33, POM34, SEC13 and SEH1. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof.</text>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-16069375">
            <id>G0S2X1</id>
        </interactant>
        <interactant intactId="EBI-16069242">
            <id>G0S0E7</id>
            <label>NUP120</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>8</experiments>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JF276295">
        <property type="protein sequence ID" value="AEL00689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692373.1">
        <property type="nucleotide sequence ID" value="XM_006692310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2X1"/>
    <dbReference type="DIP" id="DIP-60571N"/>
    <dbReference type="IntAct" id="G0S2X1">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S2X1"/>
    <dbReference type="TCDB" id="1.I.1.1.2">
        <property type="family name" value="the nuclear pore complex (npc) family"/>
    </dbReference>
    <dbReference type="GeneID" id="18255917"/>
    <dbReference type="KEGG" id="cthr:CTHT_0018790"/>
    <dbReference type="eggNOG" id="ENOG502SJ54">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007901_0_0_1"/>
    <dbReference type="OrthoDB" id="5323870at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0509">mRNA transport</keyword>
    <keyword id="KW-0906">Nuclear pore complex</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0853">WD repeat</keyword>
    <feature type="chain" id="PRO_0000433191" description="Nucleoporin NUP37">
        <location>
            <begin position="1"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 1" evidence="2">
        <location>
            <begin position="21"/>
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        </location>
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        <location>
            <begin position="162"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 3" evidence="2">
        <location>
            <begin position="237"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 4" evidence="2">
        <location>
            <begin position="282"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 5" evidence="2">
        <location>
            <begin position="351"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 6" evidence="2">
        <location>
            <begin position="455"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 7" evidence="2">
        <location>
            <begin position="494"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="57"/>
            <end position="77"/>
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    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="419"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="671"/>
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        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="716"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="423"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="683"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; EGS22354." evidence="5" ref="1">
        <original>GRKRVFFEEG</original>
        <variation>AELGKDCGKSSLFGKQKVAPAEVHSPRGGSRAREMRELLRLKPEELLDSPKMEKVKERITISPAKRKASGGLLREVLERSAKRNPALFPEKF</variation>
        <location>
            <begin position="742"/>
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    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q8NFH4"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PubMed" id="21784248"/>
        </source>
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        <source>
            <dbReference type="PubMed" id="21784248"/>
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    <sequence length="751" mass="80253" checksum="812400069D09F2DE" modified="2015-06-24" version="2">MALQPVPRMRRTLQNTQHTYSLGRRIYDVKTYPVQSPQGATILIYGHENGATVVWRGGRRLKPPKPQTNEKRNGTKPEDAVMIIDSDDETGPTFVDKPEFEDSPSVADGSVAEIIQTLDLALGTAVNHIAVLPMPPCAAEDASWNGANILKTKIVFAVTCATNDVYVITLPLTPPSHEAKARPELRKSLLAGNAGKGVWGETLTLLTGPSRSCNGVAISLVKHRSSSRSRSSERSAAQAAPITRVVVAAHSREASGTLRLWDVPLEAKPGTINRVEPFQTEYLPSPLTSISFNPVNLTQLLTVASPHAVRIYDYATASLPSDDTSEGPFPSQGSWLISLYPPFARGPAMSTSRKPIVAAEWIARGRAILTLLADGQWGIWDLDGASPTAAGGGSNLFSKTSAGLRGTAITAFSVTGHLEGTSPLRNPTTQKASSSSSGEFVPMTPHTRRDAIATAFGGSPEKLAAVRGGITVAQLPSTLTSGAGDESAVLFLGGADPIVCVIPVLSKFWDSQLRRAAGGGVNLWSGAQPTRMIRLTDLSAGLLGERCTGAVAITKAVRANASTNGILKEDDNSGSQGLPIEVLLQGESRLVIVHENGDAPTSSLTSRLLGARKKQRDEFKSVNAIVAYPPLEKPSVSFNLNLTQRPEKPGTLFAPRSRHSKSLFEQSIDTIPSTDAGDEETIPATSAPSSQQGFMFATDLELAADLPDDEADAEGRDVEQELLDIMEIDRELEQLEQARERGRKRVFFEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>G0S387</accession>
    <name>G0S387_CHATD</name>
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        <recommendedName>
            <fullName evidence="20">U3 snoRNP protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0020090</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Nucleic Acids Res." volume="44" first="7475" last="7486">
            <title>Integrative structural analysis of the UTPB complex, an early assembly factor for eukaryotic small ribosomal subunits.</title>
            <authorList>
                <person name="Zhang C."/>
                <person name="Sun Q."/>
                <person name="Chen R."/>
                <person name="Chen X."/>
                <person name="Lin J."/>
                <person name="Ye K."/>
            </authorList>
            <dbReference type="PubMed" id="27330138"/>
            <dbReference type="DOI" id="10.1093/nar/gkw562"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (3.30 ANGSTROMS) OF 81-414</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="journal article" date="2017" name="Nat. Struct. Mol. Biol." volume="24" first="954" last="964">
            <title>3.2-A-resolution structure of the 90S preribosome before A1 pre-rRNA cleavage.</title>
            <authorList>
                <person name="Cheng J."/>
                <person name="Kellner N."/>
                <person name="Berninghausen O."/>
                <person name="Hurt E."/>
                <person name="Beckmann R."/>
            </authorList>
            <dbReference type="PubMed" id="28967883"/>
            <dbReference type="DOI" id="10.1038/nsmb.3476"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.20 ANGSTROMS)</scope>
    </reference>
    <reference evidence="17 18 19" key="4">
        <citation type="journal article" date="2019" name="Mol. Cell" volume="75" first="1256" last="1269.e7">
            <title>Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration.</title>
            <authorList>
                <person name="Cheng J."/>
                <person name="Bassler J."/>
                <person name="Fischer P."/>
                <person name="Lau B."/>
                <person name="Kellner N."/>
                <person name="Kunze R."/>
                <person name="Griesel S."/>
                <person name="Kallas M."/>
                <person name="Berninghausen O."/>
                <person name="Strauss D."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="31378463"/>
            <dbReference type="DOI" id="10.1016/j.molcel.2019.06.032"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.50 ANGSTROMS)</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UTP6 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="method" value="EM"/>
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        <property type="chains" value="E=1-414"/>
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        <property type="chains" value="UF=1-414"/>
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        <property type="method" value="EM"/>
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        <property type="method" value="EM"/>
        <property type="resolution" value="4.40 A"/>
        <property type="chains" value="UF=1-414"/>
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    <dbReference type="EMDB" id="EMD-10051"/>
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    <dbReference type="EMDB" id="EMD-10055"/>
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    <dbReference type="EMDB" id="EMD-3847"/>
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        <property type="interactions" value="1"/>
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    <dbReference type="eggNOG" id="KOG2396">
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013949">
        <property type="entry name" value="Utp6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055347">
        <property type="entry name" value="UTP6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08640">
        <property type="entry name" value="U3_assoc_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="15 16 17" id="KW-0002">3D-structure</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 6 N-terminal" evidence="11">
        <location>
            <begin position="12"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="12">
        <location>
            <begin position="95"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="223"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010734"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS22470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="5IC8"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="5OQL"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PDB" id="6RXT"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PDB" id="6RXU"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="19">
        <source>
            <dbReference type="PDB" id="6RXV"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="46851" checksum="846C56EE2AEF4C01" modified="2011-10-19" version="1">MAWVADKARFYLERAAPELREWEEKEIFTKDEIRNLVAKRSDFEHLVLAPGTKPTDFLNYVNWERSLDRLRAKRCARLNIRSVTSHASQARTFGIFERAVLKHPGSIELWLAYLEFAAQVKATKRWRRIMTRALRLHPMNASLWTLAGRRAAQNGDMQRARAHFLRGCRFCTREPTLWLEYARCEMDWLARMEAKKQGQGVRKGVNALEAIKATEGQEEGDIIPIGEDTEDDSGDEDGLILPDPDAEGTDGTKKAAKPVFDAEQTKKLEQSPALSGAIPIAVFDVARKQPFWGPAAAEKFFDVFAKFGHLSCHERIISHVVTTMQELFPNHPCTWSVHIRQPLVGVDVLTPAFPKALRESLARLKAALQSTTDRKALATKMVAWMDGILAIEKLDAAIRTVLEHTKRSLEESPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3M2</accession>
    <name>G0S3M2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0021760</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
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            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <reaction evidence="10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="EGS20349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="186" mass="20886" checksum="B18EF00934C089EF" modified="2011-10-19" version="1">MAEVNPQTGLPPNWEVRMSQSKGLPYYFNTADKNSRWEPPPGTDTEKLKTYMATYHSVARPPAPQAPAYNANDRAGKIRCAHLLVKHEESRRPASWREAKITRTKAQALEIIKAYQERIKKGEISLGQLALTESDCSSARKYGDLGFFGRGEMQPEFEEAAFALKVGEISDVVETASGYHLIERLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
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    <organism evidence="4">
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
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    <dbReference type="GeneID" id="18257060"/>
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    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333">
        <property type="entry name" value="CYTOKINESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333:SF5">
        <property type="entry name" value="TRANSGLUTAMINASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="494"/>
        </location>
    </feature>
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            <end position="271"/>
        </location>
    </feature>
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        <location>
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            <end position="334"/>
        </location>
    </feature>
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        <location>
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            <end position="42"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
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        </location>
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        <location>
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            <end position="189"/>
        </location>
    </feature>
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        <location>
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            <end position="225"/>
        </location>
    </feature>
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            <begin position="254"/>
            <end position="268"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="701" mass="76975" checksum="38C157F92503D85C" modified="2011-10-19" version="1">MGDADGPHFTTLAERIAALNQQKNFHAPVPSGKRPPPPPPRPVARAATETTTTSTSTQPSSSVKPPPLPPQPTRVSTERQPPPLPRRSVDHEDSQLPSAPSPGRPPPLPARNTQQHTPQSLPPRKGSNASDVSLVSAVSSFSLNSTHSTTHEPPRRLPPRFDQSKIPPLPPKRTSEAKSKESETPEQRPRVLAPTLDQARLPPLPPSRRELEAKAKEQEAAEQQKAHTTPPLPPRRSTDSMKPVQPPPLPSRNGHPSPTTQPQESASAPTLPARRPLFKSALECGLSSGRKFPIQKPASTEPPPIPLASRPSAELPPLPLASRPSADSPPLPSNRPGVASSCLICRDFTLPDALAAANPTSSIPPHVDPIVHLAHVLCDPLPSLTDKARAIFTWCHHNIVYDVHNFLNHTVQYGLTPQQTIASGKAVCEGFARVYESIARQAGLECEVITGHGKGYGFSEIRPGDPIPRKDPTGHAWNVVRIDGGEYKLIDACWGAGHFKSCTNRYEQVFSPEWFTMSNERFGWKHFPEREGKYWFGVPKTWEEYILGPGGRDASEKAQVMGDAAREGLDDEGFVPRGKYISLSQEQVKAQSTGGLMRFLFAKVCPHWDSEKHGRGKQMLFLLKLGRYDGKDLRPVVYDGVWYFIDVPVQELGLPGQNVELVGLTMFDGRDARGLTKEEFASRFGRCAYAWTVLVRWELVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3Q9</accession>
    <name>G0S3Q9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0030290</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006693418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3Q9"/>
    <dbReference type="GeneID" id="18257067"/>
    <dbReference type="KEGG" id="cthr:CTHT_0030290"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006466_0_0_1"/>
    <dbReference type="OMA" id="LNHNPKQ"/>
    <dbReference type="OrthoDB" id="427030at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="164"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="238"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="636"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="332"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS21185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1046" mass="116451" checksum="DFCE03253184091D" modified="2011-10-19" version="1">MASILTSPPRDTTGSLPDSQPVQLPTLQQLTPPEIKPEIKQENEQEKNSRPRSASDDKDVDNLELDDAEGEEGEHGGDQAHSSNSDGPARKRRRSRKGLDKKFECPEKGCGKSYSRAEHLCGIGDCQRTFVRLDLCNRHKDRHNAKGSALNRKDSMMSQAAAPVTPVTDTRPPTFPPAPGSASPEVNRPGTAYPKPRSMSLQYPTTKDGLATPYSPMTSTPPAYPNGTQNGVDYMRHDPNYTHIPPGQAHHSPAAPRPPAIQTNVGPYSVMSPVSAQPGYHTQPHNTPQSANGMSFVPSQNFPAFQLPPSDFAANSHPSPASVAPQHRDEQQQTSYASQQSTTEFGDQQPQQQASDMMLLDQIGMQQTMPVFQVDGIINKSPYVAMPDDFMAFLFSQGGESPMTGMPMQGYNNYGDFGNYGMGYYNDSNQLGYYPQPAGPQQVMSVTNLLDQNLPEMVISEDKALEVYELIKERFHDNGRTPVERQRESILEGDRNDDNHPLSRKMMQQYIAAYWLHFSDQVPILHKPTFSPDKTPNLLLIAIMTIGAACLDKVQGQKGAKAGTPLANFLAWHLRWEMFQDPNCRPPAKLWVFQTLLLLELYEKMYSTRELHERAHIHHATTITLMRRGRALIGKSALDSPPNPRDAQNGSRQGSAAGATTPEEWWNHWIMNEATRRAAFAAFVIDSIHATMFGHSTVMVAHEMRLPLPCDDKLWKATSSAEVARIESNLMSMGCKPISFLEGLKRTLSNQEVQTNAFGRMILMAGLLSVSWHMNQRDLQVNSLGGGVSQALGGRDKWRGTLTRAFDSWKSDFDKALMKQRSELSADPYNYDLQSRNEANVVFESRIVLHHLAHMAMHVDIVDCQIFARAKRLLGRTIGPQDLNSAQRRMKDAWAPTAKARDATYYALKFLQSVLCPEQSDTPGVSYRTDGELYSASSDVLLNRPWVLYFAALVVWCYGYALEGASPGIPLPTTQQEKVQGMREYLAKYGSVQSPEELKNMQGISHNTPLLMVLKDTFDATRWELLHEGATLLNNCIQLNMGQPVA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-03-16" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3T2</accession>
    <name>PNO1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName>Pre-rRNA-processing protein PNO1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">PNO1</name>
        <name type="synonym">DIM2</name>
        <name type="ORF">CTHT_0030540</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for small ribosomal subunit (SSU) synthesis. Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the small ribosomal subunit, ribosomal RNA processing complex (SSU RRP complex).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PNO1 family.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EGS21208" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21208.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693504.1">
        <property type="nucleotide sequence ID" value="XM_006693441.1"/>
    </dbReference>
    <dbReference type="PDB" id="5OQL">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="h=1-259"/>
    </dbReference>
    <dbReference type="PDB" id="6RXT">
        <property type="method" value="EM"/>
        <property type="resolution" value="7.00 A"/>
        <property type="chains" value="CQ=1-259"/>
    </dbReference>
    <dbReference type="PDB" id="6RXU">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.50 A"/>
        <property type="chains" value="CQ=1-259"/>
    </dbReference>
    <dbReference type="PDB" id="6RXV">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.00 A"/>
        <property type="chains" value="CQ=1-259"/>
    </dbReference>
    <dbReference type="PDB" id="6RXX">
        <property type="method" value="EM"/>
        <property type="resolution" value="7.10 A"/>
        <property type="chains" value="CQ=1-259"/>
    </dbReference>
    <dbReference type="PDB" id="6RXY">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.70 A"/>
        <property type="chains" value="CQ=1-259"/>
    </dbReference>
    <dbReference type="PDB" id="6RXZ">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.40 A"/>
        <property type="chains" value="CQ=1-259"/>
    </dbReference>
    <dbReference type="PDBsum" id="5OQL"/>
    <dbReference type="PDBsum" id="6RXT"/>
    <dbReference type="PDBsum" id="6RXU"/>
    <dbReference type="PDBsum" id="6RXV"/>
    <dbReference type="PDBsum" id="6RXX"/>
    <dbReference type="PDBsum" id="6RXY"/>
    <dbReference type="PDBsum" id="6RXZ"/>
    <dbReference type="AlphaFoldDB" id="G0S3T2"/>
    <dbReference type="EMDB" id="EMD-10051"/>
    <dbReference type="EMDB" id="EMD-10052"/>
    <dbReference type="EMDB" id="EMD-10053"/>
    <dbReference type="EMDB" id="EMD-10054"/>
    <dbReference type="EMDB" id="EMD-10055"/>
    <dbReference type="EMDB" id="EMD-10056"/>
    <dbReference type="EMDB" id="EMD-3847"/>
    <dbReference type="SMR" id="G0S3T2"/>
    <dbReference type="IntAct" id="G0S3T2">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S3T2"/>
    <dbReference type="GeneID" id="18257092"/>
    <dbReference type="KEGG" id="cthr:CTHT_0030540"/>
    <dbReference type="eggNOG" id="KOG3273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064992_0_2_1"/>
    <dbReference type="OrthoDB" id="1932641at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22391">
        <property type="entry name" value="KH-I_PNO1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22392">
        <property type="entry name" value="KH-I_PNO1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000009">
        <property type="entry name" value="RNA-binding protein PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055212">
        <property type="entry name" value="KH-I_PNO1_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055211">
        <property type="entry name" value="KH_PNO1_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826">
        <property type="entry name" value="RIBONUCLEASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="RNA-BINDING PROTEIN PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22891">
        <property type="entry name" value="KH_PNO1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <feature type="chain" id="PRO_0000435810" description="Pre-rRNA-processing protein PNO1">
        <location>
            <begin position="1"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="KH" evidence="3">
        <location>
            <begin position="180"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q99216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="259" mass="28677" checksum="C3D904A45E65A076" modified="2016-03-16" version="2">MPAPTALKQPPPAPEQQAAPAITNENEDELLIDIQQAAATLTDPNAAEPPEETMENEMAVDEEGRPRFAPGKNIDPIRRIETRKIPIPPHRMSALKANWTKYPPLVDHCKLQVRMNIKEKRVELRSSKYTVSNEALQMGADFVSAFAMGFDIDDAIALLRLDSLYIQSFDIKDVRQTLGPDALSRAIGRIAGKDGKTKFAIENATKTRIVLAGSKVHILGAFENIGMARESIVSLVLGAQPGKVYNNLRIIASRMKERW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3U0</accession>
    <name>G0S3U0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0038840</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the xlnR/xlr1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS22002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694298.1">
        <property type="nucleotide sequence ID" value="XM_006694235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3U0"/>
    <dbReference type="SMR" id="G0S3U0"/>
    <dbReference type="STRING" id="759272.G0S3U0"/>
    <dbReference type="GeneID" id="18257922"/>
    <dbReference type="KEGG" id="cthr:CTHT_0038840"/>
    <dbReference type="eggNOG" id="ENOG502QUI0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006123_1_0_1"/>
    <dbReference type="OMA" id="NFPSFSM"/>
    <dbReference type="OrthoDB" id="5365785at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000004">
        <property type="entry name" value="Xylanolytic transcriptional activator XlnR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051439">
        <property type="entry name" value="XlnR/Xlr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663:SF1">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="93"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="131"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="548"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="729"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="170"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="281"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="729"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="759"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="791"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS22002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="983" mass="106799" checksum="E893DF70B3568DF8" modified="2011-10-19" version="1">MLSNPLHRFSPYHMPATTSLLSNGHVPASHLHPGLDPLAAGPHYALQQMPHMGLHNPHLARAGPQPKHRQHPYGPAARAAGAAGPIRRRISRACDQCNQLRTKCDGQQPCAHCIEFQLTCEYMRERKKRGKASRKDLAAQAAAQAAAQAAAQNANKQESQENGENKEGQSSENQSNGNSSAATTSATTSAATTSAATTTTAAAPTKPTLTVSTETRGTPDRPMTDVQRTGSMDSLGDLSAHPGPITGHPDHLNSPIDINGYPRVHAGYDRQPMGSHLMSGPTHSPYGSNQASMSSYPDLPYALQTQSPTGYTPNAQNGFPLANSPISAYPMGGETASPGWMNIHQGLRYPVLEPLVPHLGNIIPLSLACDLIDLYFASSSAAQMHPMSPYVLGYVFRKRSFLHPTKPRQCQPALLASMLWVAAQTSDAPFLTSVPSARGKICQKLLELTVSLLKPLIHNPSEEASPVSSPIVDGVALGGLGVALPGSNMDAITAECGAFGAAGTLDDVVTYIHLATVVSASEYKGASLRWWNAAWSLARELKLGRELPPHAPASRQGGASDEECSEGVPPGVITEEEREERRRIWWLVYIVDRHLALCYNRPLFLLDIECEGLLQPMDDTDYQNGNFSSYVDPALLATDPDAHAGKRARIRGPSFECTGHSIFGYFLPLMTILGEIVDLHHARNHPRFGIGFRSQREWDDQTNEITRHLETYERSLKRFEQEHLSPAAKAQLEQAAQQAAQQQAQQQTQGEGEKACEGNNNNSNTETTTTTAATTTTNNNNNNNNNNNNNPGTPSGHSVRSTGSPAPRMSESDIQTRIVVAYGTHVMHVLHILLTGKWDPINLLDDNDLWISSQGFITATGHAVSAAEAISNILEFDPGLEFMPFFFGIYLLQGSFLLLLIADKLQLEASPSVVKACETIIRAHEACVVTLNTEYQRNFSRVMRSALAQVRGRVPEDLGEQHQRRRELLSLYRWTGDGTGLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3U9</accession>
    <name>G0S3U9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAR1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0038960</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS22011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694307.1">
        <property type="nucleotide sequence ID" value="XM_006694244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3U9"/>
    <dbReference type="STRING" id="759272.G0S3U9"/>
    <dbReference type="GeneID" id="18257934"/>
    <dbReference type="KEGG" id="cthr:CTHT_0038960"/>
    <dbReference type="eggNOG" id="ENOG502QQV3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019832_0_0_1"/>
    <dbReference type="OMA" id="TENPDCH"/>
    <dbReference type="OrthoDB" id="2422440at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47482:SF5">
        <property type="entry name" value="FAR1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47482">
        <property type="entry name" value="OS11G0632001 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="304"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="442"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="362"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="719"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="35"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="179"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="304"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="319"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="785" mass="86640" checksum="34C97DA987828413" modified="2011-10-19" version="1">MSNQSNNTYPGLTFSNHYNTLRRGPFPPPHNPAGVPSVTSVTSVTTNKPSPSLTQHATHATHATHASPYAQSQHHPAAQHHPAQHQAYQPQQPQPSQYPHHLFAPSPQISSVASVQNASRPPPPPMPSLTAPGPTPRQRASVATPRQQMQQHPQHTTHAPTHTQHQPPPPPVNYMPQNLSPSLTGPSPLSQQSMAQAAQQSLSQQSLAQQSLAAATPSMSQPLSAQQLSQPSLTHQSLAQGPTLSQQLQQQAMPSPLTQSLNQTSVAQQTLAQSVQPVQQVQTTATAAAAAAAAAAAAAQQNDTATSQMLSQHATAAHHQQHHQQHHQTHTHTHTQTHTQSSLQPVQQTLGQVTQVQKTQSLQQVQQQHQQQQQQQQQQQQQQQHQHQHQHQHQQQQQQQQQQQQQQQQQQQQQHQHQHQHQHQQQQQVQVQVQVQVQHSQTQSTQVQASSSRNEPVDQGQDGHQDDDVEMVSSQADSSGNEMALVPAGGGSGSGSSGTSNALTPKVPDHHVPFIPRAPMGPMMSAPPEGGSFPTLEAIHKHVLDYCTSVGYAVVIGRSKKTVPGLKKVLFVCDRAGKPPKRVSPELRKRKTTSRKCDCPFGFFAIEQRTQWTVRYRPNPAHLQHNHGPSESPLLHPAARKLDSKMVATVKQLKESGMGVSQTLDILQQENPHVPLLPRDIYNARAAINRNPQKVASGLAENRAAIYSKPQPTPEERIRADLRRELAKVREEYEKLKEESAKEIADLKAKIEEKNKMIEKFEQFIDLCNQRVMVSLGKEREQRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3X6</accession>
    <name>G0S3X6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone acetyltransferase ESA1</fullName>
            <ecNumber evidence="4">2.3.1.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Histone acetyltransferase esa1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15 24">protein 2-hydroxyisobutyryltransferase ESA1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 25">protein acetyltransferase ESA1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16 26">protein crotonyltransferase ESA1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">CTHT_0039230</name>
    </gene>
    <organism evidence="31">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination. Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(2E)-butenoyl-CoA + L-lysyl-[protein] = N(6)-(2E)-butenoyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53908"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:137954"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:53909"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] = N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:15921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:131780"/>
            <dbReference type="ChEBI" id="CHEBI:144968"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:24181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:45949"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="4"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS22038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694334.1">
        <property type="nucleotide sequence ID" value="XM_006694271.1"/>
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    <sequence length="503" mass="57781" checksum="91C6BC1B051172F3" modified="2011-10-19" version="1">MSGGSKQPEVGSNEQRQKGKATPDTLMIGCIAMVQKDGAYRRAEILSIRETKSGRQFYCNFDNFNKRLDEWVPVSRIDFEQDVEWPNPDKDKLKDPKKKAGSSVSKKSQPSKKSQKKVGKREQSVVSEGQAGTPHPWTEFVEGQKKGKVDGDEKGVASLEVGAKGGQAGPDEMDVDEDETPAGAAKKEKAPPAFNREQEIEKLRTSGSMTQNPAEIARIRNISKVEFGQYTLFPWYFSPYPEVFSQEDCIYICEFCLSYYGDFKSFRRHRMKCTLQHPPGNEIYRDDYVSFFEIDGKRQRTWCRNLCLLSKMFLDHKTLYYDVDPFLFYVMTRRDEKGCHIVGYFSKEKESADGYNVACILTLPQYQRKGYGRLLIQFSYELSKIEGKMGSPEKPLSDLGLLSYRQYWSEQIIDLLLGYAERDEKCTIEGIATTLAMTTQDVEHTLQALKMQVYHKGEHKIVIPEKLIEQREKSRAKQRHVIDPSKIQWKPPVFTAASRTWGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0S428</accession>
    <name>G0S428_CHATD</name>
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        <recommendedName>
            <fullName evidence="4">Hyaluronan/mRNA-binding protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0022330</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="476" last="476">
            <title>High-resolution structures of a thermophilic eukaryotic 80S ribosome reveal atomistic details of translocation.</title>
            <authorList>
                <person name="Kisonaite M."/>
                <person name="Wild K."/>
                <person name="Lapouge K."/>
                <person name="Ruppert T."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="35079002"/>
            <dbReference type="DOI" id="10.1038/s41467-022-27967-9"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.90 ANGSTROMS)</scope>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2023" name="Nat. Struct. Mol. Biol." volume="30" first="670" last="677">
            <title>Structural inventory of cotranslational protein folding by the eukaryotic RAC complex.</title>
            <authorList>
                <person name="Kisonaite M."/>
                <person name="Wild K."/>
                <person name="Lapouge K."/>
                <person name="Gese G.V."/>
                <person name="Kellner N."/>
                <person name="Hurt E."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="37081320"/>
            <dbReference type="DOI" id="10.1038/s41594-023-00973-1"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.20 ANGSTROMS)</scope>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2024" name="Nat. Commun." volume="15" first="716" last="716">
            <title>Methionine aminopeptidase 2 and its autoproteolysis product have different binding sites on the ribosome.</title>
            <authorList>
                <person name="Klein M.A."/>
                <person name="Wild K."/>
                <person name="Kisonaite M."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="38267453"/>
            <dbReference type="DOI" id="10.1038/s41467-024-44862-7"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.10 ANGSTROMS)</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006692637.1"/>
    </dbReference>
    <dbReference type="PDB" id="7OLC">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="B=1-302"/>
    </dbReference>
    <dbReference type="PDB" id="7OLD">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="B=1-302"/>
    </dbReference>
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        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="B=1-302"/>
    </dbReference>
    <dbReference type="PDB" id="7Z3O">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.30 A"/>
        <property type="chains" value="B=1-302"/>
    </dbReference>
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        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="B=1-302"/>
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    <dbReference type="OMA" id="KKWAGAK"/>
    <dbReference type="OrthoDB" id="5426471at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HABP4/SERBP1-like"/>
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        <property type="entry name" value="HABP4_PAIRBP1-bd"/>
    </dbReference>
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        <property type="entry name" value="STM1-like_N"/>
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        <property type="entry name" value="AT19571P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12299">
        <property type="entry name" value="HYALURONIC ACID-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04774">
        <property type="entry name" value="HABP4_PAI-RBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09598">
        <property type="entry name" value="Stm1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01233">
        <property type="entry name" value="HABP4_PAI-RBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7 8 9" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hyaluronan/mRNA-binding protein" evidence="4">
        <location>
            <begin position="97"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="195"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS20404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="7OLC"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="7OLD"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="7Z3N"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="7Z3O"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="8OO0"/>
        </source>
    </evidence>
    <sequence length="302" mass="32606" checksum="7737E2F8BDD55C29" modified="2011-10-19" version="1">MSVASKNPFDILGNTEDETPVVPVKAVEKTSTHTAKRNTDGLPPKGHAAGNRRGGANVSGNEAAFRDRNAGRDANRGKPTDEAAPRGGRRGGFRGRGKREEGDRHPTRSAPRSNSEKQASQGWGATEGEAELKDEQAAEEIAQTEKKEAAEGEAAPEAEAKEEEPQEKVLTYDQYLAKLAEKKLALEQENALKVRKPNEGAEDKFKGLKPLTKNEDEALFAPTVQKKERQRERKTKQIIEIENRYVEERPRGGRGGRGARDGARGGRGRGGAPRGGRGGAKENAAPAINTNDETAFPSLGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0S466</accession>
    <name>G0S466_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0030880</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693536.1">
        <property type="nucleotide sequence ID" value="XM_006693473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S466"/>
    <dbReference type="STRING" id="759272.G0S466"/>
    <dbReference type="GeneID" id="18257126"/>
    <dbReference type="KEGG" id="cthr:CTHT_0030880"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_332602_0_0_1"/>
    <dbReference type="OMA" id="DYRPLYY"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="41"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="163"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="327"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="420"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="631"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS21240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="894" mass="100346" checksum="C593E6749AE3CACA" modified="2011-10-19" version="1">MIRMAPPKTGAATKSASSPKKKRPGDGKSVKAKARSKKASSVPILRLPPEIVLLITHRLDLQDKLALNRTNRWFYSIINPVIYAENVRESNAFCLFWAAENGVMGTLRHALAAGADLNATGPIPSKPIEIEPIIITDPDTENPDVNVDPDLGDEPLIEPAQRPWATPLHLAAKNGHLEVVRWLLDHGADIDAPSYRACDCQPLKTTWPASQRPAEWPRWRALHTAMCNQEREVAELLIYRGASLDLDAAPGHNHTALHSAAANALVPIIKLLALNDVNLDVNQRDAWNNTALHYVSLIWSPRESPEIRDTVTKLLALGADLEAHNNSGLTPLLYACSRGNYAVAHWLVNIGGNPDPHRHIPDFRDYRPLYYCILPRMDFFDHDDGPVKHDEFEGNRVALIHALVDNGADVDARFDKRTHRGATALMFACELAEPRAVTALVRAGADVNAQDRCGRTPLAYAVSVRLEHRHEVPEITTILLRHGARMDIEDATEHRHCPLDAAAKHIRWSEDGVLEAMLKVADASNVRESKVKEVLRNAASTGNYKALKLLLEFCDRIFHVTDDDIKEYLICIIEQSGAWSQVETFNCLMDFGRRVFTNEYLLHKALMRQNRELCLAILQRGVAVSEPRFHGNQTYLHLACQWGDIEVVNALLERGADVNIFDRELRTPLSIAVSENLTSVAISLMKEVADPFLVPPDDMFREIYSSGDPDEDDLEWRYAKKHYLTAFDIAIREDRVCIVEDIISRFCLPEIPPHTRLSYVHRAAFNPNPTILIKLLEAGADPRGGPGCRNPPFVTLIRQVWDQPRPVDNAVSLLYSARQFFRYLNGPYANAYPWALLNEIALSQPEDDDKRKVKEICMTELGLSVKCPQHKGKEPILCVRSLDLPARAKREPGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4A5</accession>
    <name>G0S4A5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">ER membrane protein complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0039480</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS22063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694359.1">
        <property type="nucleotide sequence ID" value="XM_006694296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4A5"/>
    <dbReference type="STRING" id="759272.G0S4A5"/>
    <dbReference type="GeneID" id="18257986"/>
    <dbReference type="KEGG" id="cthr:CTHT_0039480"/>
    <dbReference type="eggNOG" id="KOG3318">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098404_2_0_1"/>
    <dbReference type="OMA" id="QQTFKVI"/>
    <dbReference type="OrthoDB" id="369569at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009445">
        <property type="entry name" value="TMEM85/Emc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19315">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06417">
        <property type="entry name" value="EMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017207">
        <property type="entry name" value="UCP017207_TM-p85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="16"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS22063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="181" mass="20098" checksum="175A4101064C28E3" modified="2011-10-19" version="1">MSNTTILPAWAAGLKNPPAYKQKQPGIPDPPGYGQPSSGSSKKKDKDAKRQQPTADEMDTLKVKKAWEVALGPIKGLPMTLLMIYMTPNSLQIFSIMMVFMTFKNPIMGILGTNQAFHRFETDTNRSRILQVKVAYVAFQLVALALGIWKVNAMGLLPTTRSDWLAWEAQRDVIEHAVPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4D3</accession>
    <name>G0S4D3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0039770</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS22091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694387.1">
        <property type="nucleotide sequence ID" value="XM_006694324.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S4D3"/>
    <dbReference type="GeneID" id="18258015"/>
    <dbReference type="KEGG" id="cthr:CTHT_0039770"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_60_2_1"/>
    <dbReference type="OMA" id="IQYTMLY"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19542">
        <property type="entry name" value="CT_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000003">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000014">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056896">
        <property type="entry name" value="SIDD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF3">
        <property type="entry name" value="SIDEROPHORE SYNTHETASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24895">
        <property type="entry name" value="SIDD_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="722"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1516"/>
            <end position="1592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS22091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="2101" mass="231174" checksum="4EA91114AB64822A" modified="2011-10-19" version="1">MGSIQQHFQDARLERACDGISAFEVASLSTDDLGAPLTPEIVLFAWFIVLLRTQEDGQVFFEWASENKQPASLRANEVMQDLDSKAEDVVAAISQRPLLHVEANFSDGRLDVYPVWRSHSMLSFTIARYTRGLADTVKMYLAAPDATIQSLLVPTQHDLDQIWGWNHKLPPTYNQCMHEIIAERARQHPDKEAICSWDGSLTYGEIERYSTALAYRLRDELGVQLHDFVPLCFEKSRWTIVAVMAVMKAGACMVMMDPSLPLARLQNMGQQVGAKVMVSSLSQQDLARSILPGGKQIVVEPSIFENSPDEKEPLAPVPPDALMYIIFTSGSTGTPKGVKISHCTYTSSAYPRAKAVGYADDWRVLDFASYAFDVSIDSMMLTLANSGCLCIPSDEDRLNDINGVMRRMRVNYCGITPSVARILDLDVISSLKGLGLGGEACSARDVNYWGQKARIIIGYGPCECTIGCTVNSSAATGRDYISIGPGNGAVIWIVDPNDHETLMPLGAVGELLVEGPIVGQGYLNDPDKTAAAFINDPRWLTAGHGRYPGRSGRLYKTGDLGRYDPDGSGGIVFVGRKDTQVKLRGQRVELGEIESQLRIRLPSDANIIAEIIVPQGSSQGQATLVAFVAPGSQAPKPQDTEIELTQLPEHLVAALSKADAEISKVLPRYMVPTAYIPVNYIPSLISGKTDRRRLKIFGTKVDIRQLTAEQVAAPREAAATDRPLTEMEQRLREAWAFTLRLDAENIRLNDNFFALGGDSLAAMRLSSVCRERGLDLSVIKTFGNPTLSTMAAVVVSLSNSQAEECKPFSLINQPVEDLIKEAAKACGCKATLIQDIYPCTATQEAHITLSLKSPEPYVAQRVSCIPSHFSVEAWKKAWDLVITDTPILRSRIVQLSAHPTLLQVVINGQIPWKHSTADLEDFLVEDRNDRINLGQALARWAIVEPAGTETRYMVWTLHHAVYDGWAEPLVLDKVRNVLRQIVDGAEEIQVPTAPSTMADFAKFLHDTDQIAMKEFWRQELEGAIGPQFPRVPSRDFIPNPDVIVERKISLSTSAAKFPFTLATLIRGAWALVSSRYSGNDDVVFGETLTGRDIALPGVEGIIGPLIATVPIRVRVDRQTAVGDYLQKIQQSVLARTPYQHMGMQNIRKVSRDAQYAVEAPSGIVIQPEPAEELAKELGFEVGDVVREAIHFNPYSFMLACGIVKDGLRVCASFDSRLVSVAQVERILGQLETACLELTKDLSRKVNQVPYLPPSELNQIWNWNREPPMFFDSRSGQLKVNSSAVQPGQAFHAQATIPWVCDLHNPTMLAPIGCPGELWLEGWFLTGDTVVYSPAWLVAGSPEVPGRNGKTQPTGAIVKLQEDGNLVFIGYKDSDSTQGQAVDVTELEVHIPTQLPSIPTAAVSTGRQVLLFVEDQQGEKTVEVLSGPQTIAETTIVGTVSVTLASLLKRFDKFVQNSLAPHLLPSAYVVVDKLPVSNGRVDRTLLQQVACKISSNTVQALRAGFQTAWETITPVQTTTTAAEDILRRAWAHILRLKAEKIDTSDNFFRLGGDSVLAMKLVSHLRSEGHGLTVADIFRNMRLADAAKVLKVNQFNQELPQGKVYQPFALLDVDAKAFVAEIRPKLADNEWTVKDVLPVTDSQALDIRATVNKPRTSVQYTYLLSGPSGFNRAQLIFACNQLVRANDILRTVFIEHESTFLQVVLESLEVPVMEHTASDDLEQSVRELCNAHAESEGAFRLGAPFLHFFIVEGKDGREGFVITLSHAQYDGVSLPILLRDLEAMYTGSLTAGSVPFSSYLAHTRDEVVLSKAVSYWSKLLKGSSLSILEGQSVPAGKALFRTKTIDGATQLPQHITTASLLSAAWGLVLARRLKTMDISFGGITGGRTIDSMPDAEKVQGPCYQFTPIRIPFQSQWTASDLLEFVQRQSAESMAYDFVGWDVISKKCTDWAASGHTFFNSIVHHQDWEDFDEMPFAGQSCKVGILNPHGDAAYPLKLVSFVKKGVLNVGVVGSESDEELVESLLNDLTAAISELAASPESSLFNEAPEVVQVELRPVKDSPPLIQATSRPILGSSRKTKSKYRRRLTSLENLWRNIKQKVKHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4E9</accession>
    <name>G0S4E9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NCT transcriptional regulatory complex subunit A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Negative cofactor 2 AB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0022570</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Forms the NCT transcriptional regulatory complex with nctB and mot1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NC2 alpha/DRAP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692723.1">
        <property type="nucleotide sequence ID" value="XM_006692660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4E9"/>
    <dbReference type="STRING" id="759272.G0S4E9"/>
    <dbReference type="GeneID" id="18256295"/>
    <dbReference type="KEGG" id="cthr:CTHT_0022570"/>
    <dbReference type="eggNOG" id="KOG1659">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045277_6_1_1"/>
    <dbReference type="OrthoDB" id="653904at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017054">
        <property type="term" value="C:negative cofactor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001046">
        <property type="term" value="F:core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22906">
        <property type="entry name" value="HFD_DRAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000036">
        <property type="entry name" value="CBF/NF-Y family transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF5">
        <property type="entry name" value="DR1-ASSOCIATED COREPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="8">
        <location>
            <begin position="323"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="174"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="293"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="401"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="183"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="436"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00061393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00065307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00072430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00075891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS20427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="450" mass="48514" checksum="20624979042D38A6" modified="2011-10-19" version="1">MSDAAHDSGGGYAPRSPDLSSFHNNDDLAVGPTPALVTERAPQAPSGQQLAARGFFGSGSQHHQQKQQPSTSHPGPQEPNFSRPQLHTPANSTSPYFPDGGHQQSHALYHHHNAHHTHHRSTSQHEYHTPFTTPPHFQSQNYRPTNNSNPSQATPVFDVGVAYSHSLTTQREYIPPCVPAQPPYQQQLHQQQPSYYQSPTSYRGSFQQHHQQPYQPPQQFSPQQPHYSTAAAQAHQPYSYTPATSAGPTQQASQPDEFDQSSAMPPRRAAAAAAAAAVTAQAKNDAMTDASGTLTSTATTGTSSSASGSTANGAIQPGPVKTKFPTARIKRIMQADEEVGKVAQQTPIAVGKALELFMVALVTKSAELARQRNSKRVSAQMLKQVVESDDQWDFLRDIVSKVENDDKEKGGRGGGGAGGRANKAAESESEDESGMAKKKRGGGRRKKVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4N3</accession>
    <name>G0S4N3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0031620</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693604.1">
        <property type="nucleotide sequence ID" value="XM_006693541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4N3"/>
    <dbReference type="STRING" id="759272.G0S4N3"/>
    <dbReference type="GeneID" id="18257200"/>
    <dbReference type="KEGG" id="cthr:CTHT_0031620"/>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102602_4_2_1"/>
    <dbReference type="OMA" id="MNDTINI"/>
    <dbReference type="OrthoDB" id="10254945at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="5">
        <location>
            <begin position="14"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS21308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="101" mass="11061" checksum="0C074A79B513D8B0" modified="2011-10-19" version="1">MNDTINIAESSAATPTYTLADVQKRNKAYGVWVITHGLVYDVIKYFDDHPGDAAVLHEVAGIDATEAFKEVSHSIEANDELKMLYTGDLASEDRAASIKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0S536</accession>
    <name>G0S536_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0023950</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692857.1">
        <property type="nucleotide sequence ID" value="XM_006692794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S536"/>
    <dbReference type="STRING" id="759272.G0S536"/>
    <dbReference type="GeneID" id="18256433"/>
    <dbReference type="KEGG" id="cthr:CTHT_0023950"/>
    <dbReference type="eggNOG" id="ENOG502S8T0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003878_0_0_1"/>
    <dbReference type="OMA" id="AHPHQWS"/>
    <dbReference type="OrthoDB" id="4153178at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="892"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="984"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="695"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="752"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="921"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="594"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="700"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="770"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="796"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="810"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS20561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1010" mass="108826" checksum="02B074569B8977B5" modified="2011-10-19" version="1">MSAPPSRHGPSTPLHERSSSQQSNRIGIRIVPYSPPRIDEERASSQASSRDNNDRRDSTASQFYARRPSTRDEVIMEEGAEGSAQSPGSALPSPTKPGFSSVRSRDDRVSGVKPTGAQSAQSSQATQASPSSSSVGPTIRHVKSSSESLMGVVGQRTPSALSRWSRSSNPPSSPGSPGPAQLVRPPSRRRNLQLAIHPDGTFSLVRDGQDPSAPTLNLSPSGRSPRLSGTSRASTQDYAWSDRARRASTPFTTESTVALESVSDLPRFSACSAASSSTQIVPEEPPKSSSPWGYRLLSGLRPAPTTPEFKGRQPVYDAPLSSTTESLLPTLPEAASSVEDINEKKKKKEEEEDKQTAHDEERSVAPKSSFTSDFSSHTVQTVSERTNYKVYGPGSTAQESNDSLAFSAESAKNWEVLGPSSPAIPQIPSSPPTIPRDAGSDNYVLHGPPSISDTSSQSQATVIRRKPLPDYSQESLVVPPLRPIRKRSSERLGYYRQRSRETLRSRTGSVQSLRSLSSIFTTQDPTQALLALGPAPWALPQRPGSSYRTPKTPTGSRPSTGMIEGAPHQWSSQLSTVMSESEPASDPAMSPVPGGSSSSSSSHGYQHHRRRSSGWVSSMHSRGMPSISSSMVGQLEEAAAAVVTSAGTASDIQGPLRPPAPIRMVHEQDEHGDGLAELSHRPSKTGLSNLFQGASRYFHSPSNSRSRSRSRSNSVASRANSFTSSIPAWARVYYGSGERRWLGHKPSFLSLADTSEDGSSRPPSGYIPNGSESPGTDQFPQTIYSPRKRPREIRPGQQSQVPQTPTGRPTSQAAAASSTSMDVTPAPPTTVNNMLAPPENRFLRTLREKTSSIWSPHLLPDAHAKRYSVWDPPSVDWSADKGGLFGRRNIQIVLFALGFVCPLAWLCAAFLPLPPNPRMTWGGSASTDEEAGVDLDNAGRPSNGGRPSNGGSVGRGYPIREYQKMVMEEKKFESARWWRGLNRVMTVVGVAIIVAVIVLAVVGSRQRWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0S553</accession>
    <name>G0S553_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0032270</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693668.1">
        <property type="nucleotide sequence ID" value="XM_006693605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S553"/>
    <dbReference type="STRING" id="759272.G0S553"/>
    <dbReference type="GeneID" id="18257265"/>
    <dbReference type="KEGG" id="cthr:CTHT_0032270"/>
    <dbReference type="eggNOG" id="ENOG502TC02">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_507121_0_0_1"/>
    <dbReference type="OMA" id="HEVTECW"/>
    <dbReference type="OrthoDB" id="4587647at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052145">
        <property type="entry name" value="Mediator/Homeobox_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24330">
        <property type="entry name" value="HOMEOBOX PROTEIN BARH-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24330:SF19">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="362"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="485"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="393"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS21372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="537" mass="58106" checksum="0F33CA22478F9BF6" modified="2011-10-19" version="1">MSWAGIEIQQLRPVETVGAGERDGQDQDDREASGTGSVYSAEEEIAEDADGVGVNAVGDMSGDQHQNAGHGYDNQGRMNVGDHQSTMAGGNENSGGVQTDHQGRGNGGSSQQQQQQQHQQQAQVQELDFPRPVKRRRIGEPPEDLPQIEATPERIFKPNLPEPDDHEVTECWFEHCNARSGNTRGHNYMQKHFTDKHALIRADQGRTEIGGRFKSPKYLALCPTDWPFNYVLGPSCKWCTTIQGIRAIIGDPTHEGPAICTFCWTFLPTRADLIRHVDHGPCKSNEMYERKLAMIRDLYLAAIRMPDAPAIARAAEGARAERAAAERVARSEEWQIERAMQQRAMEHMRLWKQRQLQQQQQQQQQQQEQLGQDDVATTAEQAAPTPPAPIHTSYQASQQAPASAFSTQRFISTEDAGSEGTPGPSSYAAPAVPAPTRQSALAGTAVSYAQPAAAPALAGPGVAAGGDGTGNGWATAAIDAMARSIDRLSSVVAELTATNTQLTRELKERDERIAALEGMLAQAGAGLGGGVGRGRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5H5</accession>
    <name>G0S5H5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">6-phosphogluconate dehydrogenase NADP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0032980</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIBADH-related family. NP60 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the V-ATPase e1/e2 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693736.1">
        <property type="nucleotide sequence ID" value="XM_006693673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5H5"/>
    <dbReference type="STRING" id="759272.G0S5H5"/>
    <dbReference type="GeneID" id="18257336"/>
    <dbReference type="KEGG" id="cthr:CTHT_0032980"/>
    <dbReference type="eggNOG" id="KOG0409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035117_5_1_1"/>
    <dbReference type="OMA" id="IFSCIAN"/>
    <dbReference type="OrthoDB" id="435038at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008389">
        <property type="entry name" value="ATPase_V0-cplx_e1/e2_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF3">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G11600)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05493">
        <property type="entry name" value="ATP_synt_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="11">
        <location>
            <begin position="6"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS21440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="428" mass="47390" checksum="6484608BDF04C3FC" modified="2011-10-19" version="1">MAPTLFWIGLGNMGRGMVKNLVEKGNLENPLLLWNRTKQRSIELSEKLPSGKTQVVDTIAKGVPKADIIFIILSKDDVVEAAADEILKAGDVTGKLIIECSTLHPDTTTRLAKRFADHGAQFVAAPVFGAPAMADAGMLIGVLAGPSAAVERARPYFKGVMAREEIVMSDEPHAKALQMKLVGNSFILNMVEQLAEAHVLAEKCGLGPQYVQKFVEQLFPGPYVAYSQRMLSGDYYKRKSPLFAVDLARKDAAHIMSLAAASGTRMKNVETMDENLVRVKEHAGELGDYVAVYGILRKEAGLNRTSNFRQQESCMLKRFQELCVMSPCLAPIGMPLLELQANQHRAAHHHDACRQQPWSVFIGLVIVSGMCVAAWVFSPKGENQVLWRSSLILSIVSCYLMWAITFLAQLHPLIEPRRSDLRKEYIHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5S7</accession>
    <name>G0S5S7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0033470</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693785.1">
        <property type="nucleotide sequence ID" value="XM_006693722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5S7"/>
    <dbReference type="STRING" id="759272.G0S5S7"/>
    <dbReference type="GeneID" id="18257385"/>
    <dbReference type="KEGG" id="cthr:CTHT_0033470"/>
    <dbReference type="eggNOG" id="KOG1150">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070940_1_1_1"/>
    <dbReference type="OMA" id="EIVNKAW"/>
    <dbReference type="OrthoDB" id="342454at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46620">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN SPF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46620:SF1">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN SPF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="69"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS21489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="251" mass="29529" checksum="BE782EAE37DE0CCF" modified="2011-10-19" version="1">MATQETKEPTVTPQDAAIPAPPAQQPKQQETKTEEPVDTRDALELIEQEAKEWEKDAEIDRILKAFRLDAYAVLGLKPGVPESDIKLAYRKKSLLIHPDKTRNPLAPEAFDRLKKAQMELMDEKHRKMLDEAIADARMLVLRENKWTVDSPELKTPEFERLWTEKTKWVLIENEQRRRRQLKAQMQEQGREQRRQEEEAEARRRKREHEEAWEATREQRINSWRQFQKSKAGGSSSESSEKKKKKKLKPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0S626</accession>
    <name>G0S626_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0033940</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693830.1">
        <property type="nucleotide sequence ID" value="XM_006693767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S626"/>
    <dbReference type="STRING" id="759272.G0S626"/>
    <dbReference type="GeneID" id="18257432"/>
    <dbReference type="KEGG" id="cthr:CTHT_0033940"/>
    <dbReference type="eggNOG" id="KOG4313">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048013_0_0_1"/>
    <dbReference type="OMA" id="HRRLEYP"/>
    <dbReference type="OrthoDB" id="10261522at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044715">
        <property type="term" value="F:8-oxo-dGDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03676">
        <property type="entry name" value="NUDIX_Tnr3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000019">
        <property type="entry name" value="Thiamin pyrophosphokinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031804">
        <property type="entry name" value="DUF4743"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15916">
        <property type="entry name" value="DUF4743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="144"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="349" mass="40398" checksum="6EECA81D8957CF34" modified="2011-10-19" version="1">MAPRYTSLDLLNACDAFPDPKRNPQAYSEYMKGFYTLLWHDDEGSYPIGYVPLSVIEALKNTPSDITGRVDMDDEARTVSLFEEATNEEERTKLVGQLMKYWHENKTFQLLKSWRDELWPVYGRKGELLFNMERMAVGLIGAMRYGVHMTAFIRRKDNSSRYDFRIWVPKRAASKSSFPGMLDNTVAGGLMTDEDPLECIIREADEEASLPEDYMRAHAKETGTVTYIYITDERSGGEPGYIYPECQWVYDLELPVDGSIIPKPKDNEVESFRLHTVEEIQEQLAQGLWKPNCAIVMIDFFIRHGIYTPENEPHYDELRARAHRFIPFPGPHWPHWKPCQPRGRAAKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6D0</accession>
    <name>G0S6D0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0034480</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693881.1">
        <property type="nucleotide sequence ID" value="XM_006693818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6D0"/>
    <dbReference type="GeneID" id="18257486"/>
    <dbReference type="KEGG" id="cthr:CTHT_0034480"/>
    <dbReference type="eggNOG" id="ENOG502S7BG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042062_0_0_1"/>
    <dbReference type="OMA" id="WTENIGD"/>
    <dbReference type="OrthoDB" id="5286775at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="502" mass="57082" checksum="57F64B789A5C6A58" modified="2011-10-19" version="1">MSPMAFPKEPAPTLEEDSSSDYHSVSELSRQNEEMGLNGGTICVMQSIEDDDLDPTSYNGRHVSVSESSGSYNDLHHDDDEDDDDFDLCDYFHPFGDPYLRGRLQRKRRAGTVNQTNPRASKRARVGDSDYYDDLALQNDDDANSTSSDWDRFGTVPLCLPDWHAQLDQVDNSSLWNAEQQKLHKLIYMLGRHPVLPSSWRISFRMYGVSQGDEALQNDEDFVVFAPKRSKKRVAVRAYDNELSATKALERLFILSQTVTDYEEIGTTELIPRVIVRTIRRYLKWAMRDAGIDYRRSLPNVLIRAYSPSDFPPDSSNSKSNGNGLSNPPVESSAQKKAKALKQTQRHRRRGWVYEDEIEHEDQDGSMQQFVHHLTTDTSRRLQDLGRRWRELLDSHNAPSNGQNGTSKQDKGRSGQAIQLPTLYMFVVTEHLVMLNSYDPNSESNPVITISHVALNTRRQWAWNALWIAVVVNLAREGLLKLMNAGLVAPLTKSPNQLDPDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6D4</accession>
    <name>G0S6D4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Chorismate mutase</fullName>
            <ecNumber evidence="4 13">5.4.99.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0034520</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>chorismate = prephenate</text>
            <dbReference type="Rhea" id="RHEA:13897"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="5.4.99.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13898"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; prephenate biosynthesis; prephenate from chorismate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="5.4.99.5" evidence="4 13"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693885.1">
        <property type="nucleotide sequence ID" value="XM_006693822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6D4"/>
    <dbReference type="STRING" id="759272.G0S6D4"/>
    <dbReference type="GeneID" id="18257490"/>
    <dbReference type="KEGG" id="cthr:CTHT_0034520"/>
    <dbReference type="eggNOG" id="KOG0795">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057757_0_0_1"/>
    <dbReference type="OMA" id="ATCDVNC"/>
    <dbReference type="OrthoDB" id="191918at2759"/>
    <dbReference type="UniPathway" id="UPA00120">
        <property type="reaction ID" value="UER00203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.590.10:FF:000002">
        <property type="entry name" value="Chorismate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.590.10">
        <property type="entry name" value="Chorismate mutase, AroQ class superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008238">
        <property type="entry name" value="Chorismate_mutase_AroQ_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037039">
        <property type="entry name" value="CM_AroQ_sf_eucaryotic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01802">
        <property type="entry name" value="CM_pl-yst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21145">
        <property type="entry name" value="CHORISMATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21145:SF12">
        <property type="entry name" value="CHORISMATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017318">
        <property type="entry name" value="Chor_mut_AroQ_eu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="Chorismate mutase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51169">
        <property type="entry name" value="CHORISMATE_MUT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0827">Tyrosine biosynthesis</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="14">
        <location>
            <begin position="146"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR017318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS21589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="268" mass="30858" checksum="7EBFA1421F2B652F" modified="2011-10-19" version="1">MDSLIDLSDPSKALDLARIRYQLIRLEDTITFHLIERVQFPLNQNIYIPGAVPIPDSNLSFMDWYLREQEKLQSLIRRYESPDEFPFFPDAVQKPILPSLHYPRILHPNSINVNDKIKKFYIEQFLPSVCPDYGHGDRGVSQENYGSSATCDIACLQALSRRIHFGKFVAESKFQSDPEKFTRLIRAGDREGIADAITNKEVEKKVLERLRLKVQTYGTDPSLGPNAWNQGKINVDAVVSMYENFVIPLTKEVEVEYLMQRLDPVPNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6F0</accession>
    <name>G0S6F0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U2 small nuclear ribonucleoprotein A'</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0034680</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2025" name="Cell Res." volume="35" first="296" last="308">
            <title>Structural insights into spliceosome fidelity: DHX35-GPATCH1- mediated rejection of aberrant splicing substrates.</title>
            <authorList>
                <person name="Li Y."/>
                <person name="Fischer P."/>
                <person name="Wang M."/>
                <person name="Zhou Q."/>
                <person name="Song A."/>
                <person name="Yuan R."/>
                <person name="Meng W."/>
                <person name="Chen F.X."/>
                <person name="Luhrmann R."/>
                <person name="Lau B."/>
                <person name="Hurt E."/>
                <person name="Cheng J."/>
            </authorList>
            <dbReference type="PubMed" id="40016598"/>
            <dbReference type="DOI" id="10.1038/s41422-025-01084-w"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.80 ANGSTROMS)</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the U2 small nuclear ribonucleoprotein A family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693901.1">
        <property type="nucleotide sequence ID" value="XM_006693838.1"/>
    </dbReference>
    <dbReference type="PDB" id="9L5R">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="h=1-242"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6F0"/>
    <dbReference type="EMDB" id="EMD-62841"/>
    <dbReference type="SMR" id="G0S6F0"/>
    <dbReference type="STRING" id="759272.G0S6F0"/>
    <dbReference type="GeneID" id="18257506"/>
    <dbReference type="KEGG" id="cthr:CTHT_0034680"/>
    <dbReference type="eggNOG" id="KOG1644">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061027_1_0_1"/>
    <dbReference type="OMA" id="PNYREYM"/>
    <dbReference type="OrthoDB" id="433501at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044640">
        <property type="entry name" value="RU2A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552:SF6">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS21605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="9L5R"/>
        </source>
    </evidence>
    <sequence length="242" mass="27210" checksum="32C1DED789EFE4DF" modified="2011-10-19" version="1">MRLTAELIQNSLSYLNPLKERELDLRGHRIPAIENLGVAGPHDAIDLTDNDIQVLGNFPLSPRLRTLLVARNRVAMIHPTLPNAIPNLRNLVLASNNLTELSDLDVLGKFPRLTHLVLMDNPVTKKEVKDAERNKAKELFGTAEAPTELAAKIMGIKSKTFDVTAVPNGETQKSKLSRLKLTEKERKKLQEMIKKATSLEEIIRLEKYLNEGRLPPGIMVVEDAMEEHISMTSQSVDIWDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6K2</accession>
    <name>G0S6K2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetoacetate-CoA ligase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0026510</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693109.1">
        <property type="nucleotide sequence ID" value="XM_006693046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6K2"/>
    <dbReference type="STRING" id="759272.G0S6K2"/>
    <dbReference type="GeneID" id="18256689"/>
    <dbReference type="KEGG" id="cthr:CTHT_0026510"/>
    <dbReference type="eggNOG" id="KOG1175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_3_3_1"/>
    <dbReference type="OMA" id="MPNTWQT"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005914">
        <property type="entry name" value="Acac_CoA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01217">
        <property type="entry name" value="ac_ac_CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002937">
        <property type="entry name" value="PRK03584.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921:SF1">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="7">
        <location>
            <begin position="35"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="100"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="575"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS20813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="688" mass="75603" checksum="0B1FD7DBE4FE1CCB" modified="2011-10-19" version="1">MAATELWRHPNPEGTQMWKFLQHVNSKYGLNLKGYPDLYRWSVDNVADFWGEVWHFVGIKSSRLYDEVLPKDAPMFPRPDFFAGARLNFAENLLFPANVEVDEKATAVITATEDESQLSETSWAELRDQVRRCSSALRAVGVKENSVVAGFVANHVQALVVLLSAAALGAIWTGISPDNGVSAVLDRLVQIKPQVLFADNATLYNGKEWSSKAKTLDIVEELKKHGLEQVVVIRALKNTETGLDDIRAKGVKAEEYDAFLSRSPSNARLEFAQLPPSHPLYVLYSSGTTGLPKAIVHTAAGTLLQHKKEHFLHCSLSPSSRMLYYTTTSWMMHHWSVSALACGSSLVLYSGSPFRPHGYLSLPKLLSSLRVTHFGTSAAYLTTLEANNVLPRDDLTLDLSNLEAIYSTAAPLPPSTFSFVYRAFPARINLASITGGTDIISLFGAPCPLLPVRVGEVQCAGLGMAIDVVDSASAPEDPQPVSPPDAPGDLVCVKPFPCQPLTFFGPDGDKKYRAAYFERFPGMWHHGDFVRRADPKTDGSGLVMLGRSDGVLKPAGVRFGSAEIYNILTRFFASEVEDAVCVGRRRPQDRDETVCLFVVMAEGKTFDEDMKKRIAETIRRELSPRHVPGVIEEAKGGVPKTGNGKKIEVAVKQILSGMDVKTNASVANPEALDWFREWAKKANEDLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0S706</accession>
    <name>G0S706_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0035700</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694000.1">
        <property type="nucleotide sequence ID" value="XM_006693937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S706"/>
    <dbReference type="GeneID" id="18257608"/>
    <dbReference type="KEGG" id="cthr:CTHT_0035700"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019225_0_0_1"/>
    <dbReference type="OMA" id="WINAYFN"/>
    <dbReference type="OrthoDB" id="2915840at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS21704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="487" mass="55209" checksum="1CB0BD38B0259567" modified="2011-10-19" version="1">MLGTFEYPDFPMEPETFGIQPEPFLPRIRGEEKFGAPLFHSKDFPKHSDTIQSSKSVVVFGGTKSAFDVVYAYASQGVKVDWVIRESGHGPIWISPPYVTPLRVWLEKLVHTRLLTWLSPCIWGGVDGFKGIRKFYHETAVGRAITDAFWKVIGNDVLTLNRYDAHPETKKLKPWSNPMFVASSFSILNYPTDIFEYVRNGSVRVHIADITGLSAKAVHLSDGTRLDADALCCVTGWKYMPPVKFLPEGIDRELGLPHALDKADLFTSEEIAKADSEIFTRFPRLQDQPVQNKKFKPLLDTEGLSSSDEITSDTPLTPWTLYRFMVPPSAQLLQTRDIAFAGVLLNFTTSIIAHVQALWINAYFNNQLPADVLPTLRTNKEDAHLDVNGKSTEDIRRETLLHSRFGRWRYPAGHGDRFPDFVFDALPYVDLLVDDLGLKVRRKKGWFSEILQPYSPADYRELVEEWLENVKRVESSEGCSADSGSYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>G0S792</accession>
    <name>G0S792_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V-type proton ATPase catalytic subunit A</fullName>
            <ecNumber evidence="2">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CTHT_0027860</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Vacuole membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693243.1">
        <property type="nucleotide sequence ID" value="XM_006693180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S792"/>
    <dbReference type="STRING" id="759272.G0S792"/>
    <dbReference type="GeneID" id="18256824"/>
    <dbReference type="KEGG" id="cthr:CTHT_0027860"/>
    <dbReference type="eggNOG" id="KOG1352">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008162_3_0_1"/>
    <dbReference type="OMA" id="RIVKTFW"/>
    <dbReference type="OrthoDB" id="1676488at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18111">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18119">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01134">
        <property type="entry name" value="V_A-ATPase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000002">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000008">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000052">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000003">
        <property type="entry name" value="Vacuolar ATP synthase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00309">
        <property type="entry name" value="ATP_synth_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005725">
        <property type="entry name" value="ATPase_V1-cplx_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003220">
        <property type="entry name" value="PRK04192.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01042">
        <property type="entry name" value="V-ATPase_V1_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607:SF1">
        <property type="entry name" value="H(+)-TRANSPORTING TWO-SECTOR ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="V-TYPE PROTON ATPASE CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="17">
        <location>
            <begin position="220"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="ATPsynthase alpha/beta subunit barrel-sandwich" evidence="18">
        <location>
            <begin position="323"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="16">
        <location>
            <begin position="428"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="19">
        <location>
            <begin position="661"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="22"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF16886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGS20947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="809" mass="87056" checksum="38F9B682FA57DAC1" modified="2011-10-19" version="1">MQVGLRPQLKTRRSLVDLLVGSGSSEFSAPSSSTLSRPNSGSNSGVGGSQGSTETSVAAFGSPMAAGPSTASIAQFPQLQSASTAPVSDAQQHKQHKQHEQQQANVDLELPVQVSGPDDIQPPPSPAASQPPSTPDSASASPAPAPPSLTPDPSRHWTSSVPAIVVHSAPSSPASPNPAAPRSTPAAPASSASSASLTSSPTMAPSKTDDSQEGFHPGKIYSISGPVVVAEDMTGVAMYELVKVGHDKLVGEVIRISGDQATIQVYEETAGVTVGDPVIRTGKPLSVELGPGLLNNIYDGIQRPLEKIAGISKSIYIPRGIAVPALDRSKKWDFTPTMKVGDHITGGDVWGHVFENSLISVHKIMLPPRARGVITRIAPKGSYTVEEKLLEVEFDGKKTEYPMMQTWPVRVPRPITEKHSADKPFLVGQRVLDALFPSVQGGTVAIPGAFGCGKTVISQSVSKFSNSDVIVYVGCGERGNEMAEVLKDFPELTIDVGGRKEPIMKRTTLIANTSNMPVAAREASIYTGITVAEYFRDQGMNVAMMADSSSRWAEALRELSGRLGEMPADQGYPAYLGAKLASFYERAGKVQALGSPYREGSVSIVGAVSPPGGDFSDPVTSATLGIVQVFWGLDKKLAQRKHFPSINTSLSYSKYTAVLDKWYEKEYPDFPRLRDRIRQLLSDSEELDQVVQLVGKSALSDPDKITLDMATLIKEDFLQQNGYSEYDAFCPIWKTEWMMKLMMGFHDEAQKAVAQGHTWAKIREATQDLMAQLRQLKFELPSDGREAVCKRYEAIQQAMLDKFASVVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7G6</accession>
    <name>G0S7G6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Putative myosin MYO2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0028070</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693264.1">
        <property type="nucleotide sequence ID" value="XM_006693201.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S7G6"/>
    <dbReference type="GeneID" id="18256845"/>
    <dbReference type="KEGG" id="cthr:CTHT_0028070"/>
    <dbReference type="eggNOG" id="KOG0160">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000192_3_1_1"/>
    <dbReference type="OMA" id="EIMFDDR"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15480">
        <property type="entry name" value="fMyo2p_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01380">
        <property type="entry name" value="MYSc_Myo5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046943">
        <property type="entry name" value="Fungal_Myo2/2A_CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036103">
        <property type="entry name" value="MYSc_Myo5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF706">
        <property type="entry name" value="DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50084">
        <property type="entry name" value="Myosin S1 fragment, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 9" id="KW-0518">Myosin</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="14">
        <location>
            <begin position="6"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="13">
        <location>
            <begin position="74"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="12">
        <location>
            <begin position="1226"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="9">
        <location>
            <begin position="656"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1082"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1560"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="946"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1570"/>
            <end position="1584"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="168"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS20968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1597" mass="182217" checksum="AD2AD901E6D63A65" modified="2011-10-19" version="1">MAEGYEVGTRAWQPDPTEGWVASEVIKKTVEGDKVKLDFKLENGETRTVEVTLDALRSGNDPSLPPLMNPAMLEASDDLTNLSHLNEPAVLQAIRLRYAQKEIYTYSGIVLIATNPFARVDSLYVPGMVQVYAGKQRATQAPHLFAIAEEAFMDMLRDNKNQTIVVSGESGAGKTVSAKYIMRYFAMRESPDHPGSRTKKGGEAMSKTEEAILATNPIMEAFGNAKTTRNDNSSRFGKYIEILFDKETNIIGAKIRTYLLERSRLVFQPLKERNYHIFYQLVAGVSEKERQELGLGPVEQFDYLNQGNTPTIDGVDDKAEFAATKQSLSMIGVSEANQAEIFKLLAGLLHLGNIKIGASRTESVLSPTEPSLVKACEIFGIDAAEFAKWIVKKQLVTRGEKITSNLTQAQAVVVRDSVAKFIYSSLFDWLVEVINKSLAAEEVLNRVHSFIGVLDIYGFEHFAKNSFEQFCINYANEKLQQEFNQHVFKLEQEEYLREQIDWTFIDFADNQPCIDLIEGKLGILSLLDEESRLPMGSDEQFVTKLHHQYGNDKHKFYKKPRFGKSSFTICHYALDVTYESEGFIEKNRDTVPDEHMAILRASTNRFLREVLETAAAVREKDVAASASNAVKPAAGRKIGVAVNRKPTLGGIFKSSLIELMNTINSTDVHYIRCIKPNEAKEPWKFEGPMVLSQLRACGILETVRISCAGYPTRWTYEEFCLRYYMLVHSSQWTSEIRTMAEAILKKALGSAPPGKPGMDKYQMGLTKIFFRAGMLAFLENLRTNRLNECAILIQKNLRAKYYRKKYLAARDSVVAFQTLWRAHKARVQAQEMRTIKAATTIQRVWRGTKQRKEFLRIRNDIIRAQAIFKGYLKRKEIMETRMGNAAIIIQRNWRSRRQIRAWRDFRRKVIIVQSLWRGRRARKEYKVLRAEARDLRQISYKLENKVVELTQTLGTMKAQNKELKSQVENYENQVQMWRNRHNALEQRTRELQTEANQAGIAAARLEQMEIEMKKLQASFEESVANVKRMQEEERKLRDSLRATSSELEAARLESQRHEAEKNSLRQQLAELQEALEQVRRNAPANGDNTHNHAAPPGLINLVSTKKPKRRSAGAELRDMDRYSMAYNPRPVSMAVPGMNRQTTLSGSTLFPGVDSIELELEALLADEEGLNEEVTMGLIRNLKIPSPTSNPPPSDKEVLFPSYLINLVTSEMWNNGFVKESERFLANVMQSIQQEVMQHDGDEAINPGAFWLSNVHEMLSFVFLAEDWYEAQKTENYEYDRLLEIVKHDLESLEFNIYHTWMKVLKRKLNKMIIPAIIESQSLPGFVTNENNRFLGKLLQGSSQPAYSMDNLLSFLNSVYRAMKGYYLEDSIITQCITELLRLVGVTAFNDLLMRRNFLSWKRGLQINYNITRIEEWCKSHDMPEGTLQLEHLMQATKLLQLKKATLNDIEIIQDICWMLSPNQIQKLLNQYLVADYEQPINGEIMKAVASRVNDKSDVLLLPAVDMDDSGPYEIAEPRVITALETYTPSWLPCPRLKRLAEIVSQQAIAQQEKLEYEQQLAAGMYGDQDLGDDEGDLPPESELEPPRRPTSLTASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7K1</accession>
    <name>G0S7K1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="4">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CTHT_0036600</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>XMP + L-glutamine + ATP + H2O = GMP + L-glutamate + AMP + diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="4"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694088.1">
        <property type="nucleotide sequence ID" value="XM_006694025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7K1"/>
    <dbReference type="STRING" id="759272.G0S7K1"/>
    <dbReference type="MEROPS" id="C26.957"/>
    <dbReference type="GeneID" id="18257698"/>
    <dbReference type="KEGG" id="cthr:CTHT_0036600"/>
    <dbReference type="eggNOG" id="KOG1622">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014340_0_5_1"/>
    <dbReference type="OMA" id="IWQSFAV"/>
    <dbReference type="OrthoDB" id="1724632at2759"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003921">
        <property type="term" value="F:GMP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000017">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000001">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000001">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000848">
        <property type="entry name" value="PRK00074.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922:SF2">
        <property type="entry name" value="GMP SYNTHASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922">
        <property type="entry name" value="GMP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54810">
        <property type="entry name" value="GMP synthetase C-terminal dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="8 16" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 16" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="17">
        <location>
            <begin position="205"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="233"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGS21792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="538" mass="59448" checksum="66A87F992845193A" modified="2011-10-19" version="1">MNGEPGEAMAHKAFDTILVLDFGITRRLRELNVFSEMLPCTQKLAELKFKPKGIILSGGPYSVYEDGSPHVDPAVFDLDVPILGICYGMQELAYRISPDNVIAGKHREYGHSMLKARSIGGHVDRLFEGIEDSMRVWMSHGDKLAKLPEGFHTVATSDNSEYAAIAHESKPIYGLQFHPEVTHTQNGTALLKNFAVNICGCKQDWTMEKFLEQAIAQIRETVGEKGQVLAAVSGGVDSTVAAKLMKEAIGDRFWAVLVNNGVMRLNECEQVQKDLSEALGINLTVVDASKEFLEGLKGITDPEKKRKFIGGKFIDIFEAEAIKIEEAAAKDPTKGGGKIEFFMQGTLYPDVIESLSFKGPSATIKTHHNVGGLPERMMNGQGLKLIEPLRSLYKDEVRALGRALGIREELVMRHPFPGPGIAVRILGEVTPEKVEIARQADHIFISEIRKAGLYDQISQAYAAVDPSRAVGVMGDKRVYGYIVVLRAVTTTDFMTAEAFNFPWEFLQRVMNRIVNEVHGVCRVVYDITSKPPGTIELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7K9</accession>
    <name>G0S7K9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Metalloendopeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0036690</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694096.1">
        <property type="nucleotide sequence ID" value="XM_006694033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7K9"/>
    <dbReference type="STRING" id="759272.G0S7K9"/>
    <dbReference type="MEROPS" id="M03.009"/>
    <dbReference type="GeneID" id="18257707"/>
    <dbReference type="KEGG" id="cthr:CTHT_0036690"/>
    <dbReference type="eggNOG" id="KOG2089">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001805_1_1_1"/>
    <dbReference type="OMA" id="KNFQSAM"/>
    <dbReference type="OrthoDB" id="534666at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06455">
        <property type="entry name" value="M3A_TOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000006">
        <property type="entry name" value="Thimet oligopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.40">
        <property type="entry name" value="Endopeptidase. Chain P, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024080">
        <property type="entry name" value="Neurolysin/TOP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF84">
        <property type="entry name" value="SACCHAROLYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="8">
        <location>
            <begin position="245"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS21800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="722" mass="82123" checksum="F386A61CFE7D6F1D" modified="2011-10-19" version="1">MSKYANPPQAPPLFTGTKESIVADSKALCDRTRQLLDNLVATIKPDEDPASATFESVLKPQIEDENQASLSNRVLGFYQYVSADSELRNASTEAEKILDEFAIECSMREDVFRLVDAVYKNSGLSETLEKDKDRVIDEALAKSVGFDDIESARLLHKERKSYIKNGLGLPEGPQRDRFKEIKKRLSQIQIEFQKNLNEENGGLWFTPEELDGVPQDVLDTLEKGTGENEGKLRLTFKYPDLFPTLKFAKNPETRKKVFIANENKCNQNVPLFKEAILLRDEAARLLGYPDHASFRIEDKMAKTPQAVLDFLNDLKTRLAPGGVKEREHLLELKKKDHEARGLPFDGNYYLWDHRFYDRMMVEQEYSIDENAIAEYFPLKSTVAGMLRIFEELFGLVFVELTPEDRKRISPTGKAEDIAWHEDVIIFSVWDDDTEGNGFVGYLYLDLHPRPGKYGHAANFNLQPGFLKSDGTRHYPATALVCNFSKPTPTKPSLLKHDEVVTLFHELGHGIHDLAGRTRYSRYHGTSTVRDFVEAPSQMLENWCWTPSQLKSLSSHYQTGAQIPDELIEKLIATKHVNDALFNLRQLHFGLFDMAVHTPKHHGELEELDVSKLYNELRAQISQIQGPEALGEPSTWGNGQATFGHLIGGYDAGYYGYLYSQVYSTDMFYTAFKTNPMDPVQGRRYRHTVLEKGGSQDEMLSLTQFLGRKPSTEAFYKELGLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0S829</accession>
    <name>G0S829_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative UPF0673 membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0029170</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693372.1">
        <property type="nucleotide sequence ID" value="XM_006693309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S829"/>
    <dbReference type="STRING" id="759272.G0S829"/>
    <dbReference type="GeneID" id="18256955"/>
    <dbReference type="KEGG" id="cthr:CTHT_0029170"/>
    <dbReference type="eggNOG" id="KOG2852">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_14_0_1"/>
    <dbReference type="OMA" id="NPAHDGI"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF150">
        <property type="entry name" value="OXIDOREDUCTASE TDA3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="40"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS21076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="501" mass="54785" checksum="FC5A0BB5ABF66957" modified="2011-10-19" version="1">MGDRSHLGWAPVNLVTMQGFRSRGVGRAPGDMDTQERRHIVIVGGGIIGCTTAYYITRHPKFNPALHTVTLLEATEIAAGASGKAGGLLALWAYPDCLVPLSYRLHKELAAEHDGEKKWGYRRGLGCGSVYAVVKAADLKERKRKRVPTPPSRPNNDDGNGKLSLESVAQLEEKGKYWEKLPKQDEAAAKLLKDSPLPPDLDWIEGRLVTHYEEMGTPGVTETAQVHPRYFTQTIAELAKQAGVDIREGAKVMKIGEVESESEGEENAEGQTNTKGTIAKGKRVQSVEYEDRATNEIRTIDDVTDVVVTAGPWTGKLLPQTQIGNIRAHSVVFEADVSPYAVFTSIQLPAKWVPEHMAARGERRRHGRHVDPEVYARPGKEVYACGETDNDVPLPPTAEEVETDLSRCEDIIAYIGTISPQLASAPVKTRQACYLPLHKRDGEETGPLIGPMATKGLWVAAGHSCWGIQNGPGTGYLMARMLFGDEVDESVAQLGPKKYNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0S900</accession>
    <name>G0S900_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0044040</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694796.1">
        <property type="nucleotide sequence ID" value="XM_006694733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S900"/>
    <dbReference type="STRING" id="759272.G0S900"/>
    <dbReference type="GeneID" id="18258442"/>
    <dbReference type="KEGG" id="cthr:CTHT_0044040"/>
    <dbReference type="eggNOG" id="ENOG502RKST">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_302715_0_0_1"/>
    <dbReference type="OMA" id="TRSKKHW"/>
    <dbReference type="OrthoDB" id="4848543at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="652"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="691"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="744"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="801"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="43"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="199"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="369"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="755"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="824"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="850"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="879"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="924"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="967"/>
            <end position="987"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS19911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1017" mass="114110" checksum="BC4BBE154FF5E53F" modified="2011-10-19" version="1">MLRQRRVDISQHFAENMATIVNKYQQEQCATLQLEKAKYHKYIKRLRKELAEAAETLEQYAINSEAQSREILALQTAKYEMSGQLADFEAKLKTSEERFQKLNEKYHTCKTYINSAIDEQQDLYTRSKKHWDEVVEQLRAMERARNAEVEMTVRKAEVIREQMMEKVRQTIAQNKAEATQLYGQINLLTDQIKEKDSELGKERETVRLLSERLKELQETASCFEALAAQSKKIFDKLEEQQKEADNRHQKETKDFQQRLDALASRLEALSNVVSGQLDTLSNIQDTQANSLKSIVTKLDTILEAGGNAEEAISQLSKDLGTHADKIWLRLDNQLESLASQLTNKAEEHGKTEALYKKQVAECEKHQTELSHLHEIAQQQADKIHELENDLLAMDAAYEENKEAIDYLQSIEAEANELREELTSKTTSLTELQIKLNEKTQAYASELEILSSNLMKLSQAAKEKEKAFQVATEQAVKNARQELLLEMQAAKADAEKRLSEKQQELDSISAQLERSKQELQEKERSEHQAAMVINSLKESLGSAEARAVTATQELAQSTASAEQLRSNLGSRIKTLEEELINHKKRVSEYEEQVRSQDAKYRALTTALEQWALKQGLDVNSLTFLKTSNGSAEEINAEIMRALEQLAGLHQKNTNYESGQSGLSPINSNAAGPANHSGSQEVQLIHENPTEGHQDQLVQPGASKRSPSEPADLSSGMEIAAGGALSSFQVKRLDQIRRVIVRSPANVSSEPNAPSVDQEKARRREAVRPKSIMKRVTRSTSAALSLQGREDFAVQTQGAFASHPDGLALNEGEHNFPTTPKTERTVQSNSFVPSSSVSERVSKRRHPVDVGLENRDDTPRSSKQPRSEPTTKRLRRRLLTESGSGKKNVEQQQYPMRQGAQHLPGNVFNPTLSVPPPSAQKESRFAPTTSQKGGLMNAPQSLSQKPINLRTYGSQRTTSLTGASRQGESQSSLYSRSQSQSQSQPQYLLKSEDSQDSLTMSQNRLADANILLSFPNLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G0S926</accession>
    <name>G0S926_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Vacuolar protein sorting-associated protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CTHT_0044300</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Endosome membrane</location>
            <topology evidence="2 12">Peripheral membrane protein</topology>
            <orientation evidence="2 12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the VPS27 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694822.1">
        <property type="nucleotide sequence ID" value="XM_006694759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S926"/>
    <dbReference type="STRING" id="759272.G0S926"/>
    <dbReference type="GeneID" id="18258468"/>
    <dbReference type="KEGG" id="cthr:CTHT_0044300"/>
    <dbReference type="eggNOG" id="KOG1818">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011862_1_0_1"/>
    <dbReference type="OMA" id="DQQCSAK"/>
    <dbReference type="OrthoDB" id="957735at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15735">
        <property type="entry name" value="FYVE_spVPS27p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21385">
        <property type="entry name" value="GAT_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16979">
        <property type="entry name" value="VHS_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1940:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000031">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000161">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017073">
        <property type="entry name" value="HGS/VPS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049425">
        <property type="entry name" value="Vps27_GAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21356">
        <property type="entry name" value="Vps27_GAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036956">
        <property type="entry name" value="Hrs_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0967">Endosome</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VHS" evidence="16">
        <location>
            <begin position="26"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="15">
        <location>
            <begin position="168"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="287"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="522"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="476"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="560"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="604"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="637"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="652"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="717"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR036956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGS19937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="755" mass="82803" checksum="37C9520C1325C42A" modified="2011-10-19" version="1">MMSWWSSGANSALEEQIEKATSSSLEDISLNLEISDIIRSKTVAPKDAMRALKKRINHKNPNIQLSALNLTDTCVKNGGAHFLVEIASREFMESLVSLLRAVGPAAVNAEVRAKILELIQSWATATEGRYELGYIGEVYRNLQREGFQFPPRVNVSSSMIDSSAPPEWVDSDVCMRCRTAFTFTNRKHHCRNCGNCFDQQCSSKTLPLPHLGILQAVRVCDGCHIKLTDKSTSRRATQDKSTLYSNFPGNKQRTHMEPRSARVEDTFDEDLKKALAMSLEEVQAHNRGYNPSAANGPSSQSKVNGNARPKSIEEEEDEDLKAAIAASLADMEEQKKKHAAALKEQASNAATSSAAHFTLPKNDYELTPVEAENINLFATLVERLQTQPPGTILREPQIQELYDSISALRPKLARTYGETMSKHDALLDLHAKLSTVVRYYDRMLEERLSRAYSQHNIGYNLPPLRQTTGAYPSLQPTAPSAPATVPSAESFYTGETSNQTIAQQSYAQSTPQAQYANYDRRSSMAMVSQPPQAYPPQQVPQPTGTWGAQPPGQAPPYAPQPSYSSSQPATDPSAPALAQPSAPPTAPDQVPTADPAASFYFNPSAPPQQQPSQPQPQPQQPPPSSVPDATVSPYPNLAQSIQALQGSVPQTPASAPVQLSQPAQAPQQQQQTPQQQQQPLQPQKPPQTLQQQSQQQPQQPYWQYPAAQQMPLPPVWQPSQQQQQSSSVTPDAFPSAPQHAPAPKQPVVEEALIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0S991</accession>
    <name>G0S991_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0044990</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL50 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694887.1">
        <property type="nucleotide sequence ID" value="XM_006694824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S991"/>
    <dbReference type="GeneID" id="18258537"/>
    <dbReference type="KEGG" id="cthr:CTHT_0044990"/>
    <dbReference type="eggNOG" id="KOG4500">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_279504_0_0_1"/>
    <dbReference type="OMA" id="LANCPAN"/>
    <dbReference type="OrthoDB" id="26149at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040144">
        <property type="entry name" value="RAP1GDS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018305">
        <property type="entry name" value="Ribosomal_m50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10957">
        <property type="entry name" value="RAP1 GTPASE-GDP DISSOCIATION STIMULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10501">
        <property type="entry name" value="Ribosomal_L50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS20002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1139" mass="125275" checksum="1E27C9ACA4D404D6" modified="2011-10-19" version="1">MRCIPRLRSPAAAAIVCQSSTAASATLRIPAITPAAATPATISTLLSSTNHSPSCSCPLHSQTARRYLSTTPARPEHQQEQAAAQEEEYVEYPSRPQIQTDLVIPGRIRSAPISEKITDATYTPAETADGLVEIGGLDKWWDDPMHWGGPEGPARAVAVAAPRFGPVQRMTDPAYLEAITKRAIIEAIVLAKYFHGSNDKRDQEVLRRVFNVFGGNDWLLKMMEIELVAGEDGAVKIKDFRDEHSVRDVMKDAVAKAIKAEKEGTEVPRTEVVWTPKFRASTAKKMVESWGKEWKKAELRDPVVKFYAAKRIQQLTGHRIPDGKLHGYKTIEALLRHLVDPPKAKKLFEVVQQKGVFNELPNVKVFPRRVTPIDEEQMVGRWKVIVRELKKRELPIIGHEHLEGPVEQRWITGKNNDLLNGRISVPEGEDEKSWRTDQLKNVLQTVQQGTADGQASIIELLANAARDQSWRSALGESGLINFVLDVVSADGPLAPDHPLNKQVLRFLGNGCADNEPNRAIIEKTGKLPAFILRCLKEESLMPFACIAALNYCLDYLPAQSQMSAYGLSKALVDIVSGDRLEWCLEGPLPSLSHIMTVLELLSNQDHEPSKAYPDTPSQLLKLATSDRYDADLDSFMEICSPALAYLTSSHFQTHFLSSQNLILIEEAFTQLYTRFDTSDIDEDTAAQLKQIGEAFLTVFADLSALPDFSTACSLDSQPGRTLASWLESSQPPYLQAAACLVLGNLSRSDESSIALLPKVQSSLVGILIRMIPSSQSPTDISKPTGWSPIQLTHAALNFAKNLAIPAANKPSLGAALLDPVHPILPRLWSSTRTQPQLQFAAVSLTRLLLVNCPSNVTLLCTPLEANNNNGPSTLALLVSASTSADADPIKHEVSRAVATVCRALHSPNTNTTSPVLNPSWNWGASDAPSPLAAFYTTHSAHIVNALRHPLMQTRFPALRADVIFTLALMTRSSEEGAKVALRVFLPPSEPREGVEMDEKAKKKQEKEKAEAKTCWLALAEVILGADEAKKLEGLFLFGDTSAQGSEDRGEDSKREEKDGDVSVIQVGMDGLSLSPQQIDMQAQKEQPAHAVRMNRENGLVLLAELFRRFTEELALLRKTIETLLTKGGEFVVKDRQEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0S995</accession>
    <name>G0S995_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-ketoacyl-CoA thiolase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0045030</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694891.1">
        <property type="nucleotide sequence ID" value="XM_006694828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S995"/>
    <dbReference type="STRING" id="759272.G0S995"/>
    <dbReference type="GeneID" id="18258541"/>
    <dbReference type="KEGG" id="cthr:CTHT_0045030"/>
    <dbReference type="eggNOG" id="ENOG502SZUB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018105_1_0_1"/>
    <dbReference type="OMA" id="NATEMSQ"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="314"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="364"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="481"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="585"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="243"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="399"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="481"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="532"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="552"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="585"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="626"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS20006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="656" mass="70614" checksum="F962A99E8845DB0F" modified="2011-10-19" version="1">MSSDSEQSAQVARSIPDEEQQAALGVEVASASSQRDDISVVSSSQQSIPPTEAPNSPLDHHPSAFKSEPQENPAAAPAIAARAASVLSSSQTPPPSSQIAGMTGQAAPANTMTYLSSQRAGIFSPPATTAPNGLKRESIPPEFAAPTPAQIAEASVEDLRSMLQASLAEQARLKTEVAHYKMEAAHHKLQYNMLSLRAEEDSKRAAVEHEITKKEVQVLQKAEYARQARQDLIAANESAQVKYLQLKVLHERALEEIELLQKKLKAARKILKQNQDEIASLMDEREILLNRIRENREHFHILCSPGGMFYSAVSSSRAHQQAASPQQHRATPRQTPRSAVQRETHREHQNGEGFAVLLQALSQDNNNNVNNDPSVPSTPSTSQRPGAARVGSSVKHTRNVQSTSSLPSTPVSKTRSDGRGGLLPSVDLIPQTEPAYRNARFIPETPATPRGGRERRKSRESTISAEDNQELARQALQSFASRGAGSSGGVPHSHPHPHHQRVDQSPNQRRRASMADDVEVYESQASQAASEMLRRDPRESYEVAQSRDPTPANTTTSSGGAMTASGSGAKLQAKLFGGLNKSGLSTSAAAPLASSSPAKRKLSHDAGIEGGGADARERALMSPTKRLREVGGLRGDPISHPHSGERRVGLGIYGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9X8</accession>
    <name>G0S9X8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative 2 iron, 2 sulfur cluster binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0047550</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695124.1">
        <property type="nucleotide sequence ID" value="XM_006695061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9X8"/>
    <dbReference type="STRING" id="759272.G0S9X8"/>
    <dbReference type="GeneID" id="18258793"/>
    <dbReference type="KEGG" id="cthr:CTHT_0047550"/>
    <dbReference type="eggNOG" id="KOG1336">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003291_4_2_1"/>
    <dbReference type="OMA" id="PRCTHYG"/>
    <dbReference type="OrthoDB" id="6029at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03478">
        <property type="entry name" value="Rieske_AIFL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050446">
        <property type="entry name" value="FAD-oxidoreductase/Apoptosis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557:SF2">
        <property type="entry name" value="RIESKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="10">
        <location>
            <begin position="7"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS20239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="542" mass="57158" checksum="2DAAE681071E8CD2" modified="2011-10-19" version="1">MAQEYKLKGITSLALKPGEKLEAEVEGLDTKVLLLNAGGNVQAVGSRCTHYGAPLVKGVVGANGTITCPWHGACFNGKTGDVEDAPALDPLPVFKAIERDGAVYISGDAAVIKNGYRKPNFQCAASGGDKVLVVGGGSGALGVIEGLREKGFRGAITLITNEGYLPIDRPKLSKALMTDLGKLQWRDESWFKSGSVDIVNDEVTSVDFATKTVTTKTGSKFAYTKLVLATGGTPRALPLPGFRELGNIFTLRTVHDTKKIVSVIGEKGKKIVIIGSSFIGMEVAVATAAGNQVTVVGLEKVPLERVLGEKVGAIIQKGVEAKGVKFYLSASVEKAEPSPSDPSVVGAVYLKDGTRLDADMVILGVGVTPATEYLKGNSQVQLEADGSIKVDESFSVIGLEGVYAIGDIATHPYHGPGGDGKLVRIEHWNVAQNAGRTAARHIVDPTVKPRFYTPVFWSALGSQLRYAGNTTASGWDDLILQGDPDQGKWVAYYAKGETIVAMASMGMDPVMAQCAQLMSLNKMPTKTQLIGGLDVLSLGPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2023-02-22" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9Y2</accession>
    <name>G0S9Y2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0040290</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694439.1">
        <property type="nucleotide sequence ID" value="XM_006694376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9Y2"/>
    <dbReference type="GeneID" id="18258067"/>
    <dbReference type="KEGG" id="cthr:CTHT_0040290"/>
    <dbReference type="HOGENOM" id="CLU_2549076_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS19554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="83" mass="9821" checksum="59FA167D8B3B1B66" modified="2011-10-19" version="1" fragment="single">MAPASASFLSALRKARDVKVKELNALVSVVEKLYAAIENVRVRVRVRVRVRVRVRVRVRVRVRVRVRVRVRVRVRVRVRVRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9Z7</accession>
    <name>G0S9Z7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0040470</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694454.1">
        <property type="nucleotide sequence ID" value="XM_006694391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9Z7"/>
    <dbReference type="STRING" id="759272.G0S9Z7"/>
    <dbReference type="GeneID" id="18258085"/>
    <dbReference type="KEGG" id="cthr:CTHT_0040470"/>
    <dbReference type="eggNOG" id="ENOG502S0Z5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035325_0_0_1"/>
    <dbReference type="OMA" id="PGMGFYQ"/>
    <dbReference type="OrthoDB" id="4092340at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="323"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="410"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="182"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="440"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="481"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="500"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="544"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="556"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS19569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="621" mass="66355" checksum="A1772BF2B715D217" modified="2011-10-19" version="1">MDSGSLTQMHAPFNQAPGMGMPSGLASRRGGAQNIKPLSFDALKSASGVDNGLPTPRTARSHLLAGLRTAPKSATVSSFSTLPSSPTTAAPQGRNRNSMIGGGGGLYDATNLYNNPPKTSLPRFASQQPQLQPQAQAYNPMMGFAQQYTTDQVLAPPQINLDDAAREGTIDPALHAQLLYTNAYLTEQQQRLQQQLRALQEAAQQFQNMNLNGQSQMMQQQMYPSVYQQQLQNTQAMMAPTAPHQANMYGVYNPAASQQSLYMDQTTQSQLNAQLTAQLNAQLHAQLNAQIQANQAQLVSAYAALQQQQQQAQQAQQAQQQQAQQAAIGTPRVQVSPPPASANNNRPGFRVPTPPRCFDSPSESASNLTQQNAARRPGHKKTPLGGKTQLMISVNDEPLKSAAPKTAVFPLTPMTSSYGPGQARAGEHPIRQPRNPPSLDELRSKPTAKHEGSKNFVARTRRSAVHNLVRAGLERRKEARSSGSGSTSPTSETTEEAIQTPLTDNDSDSVRSGSGSLIDRDDCMLPPSTRSSTSSWGAIGSDRPSSRQKAERKNSAENVSLTPDNEGSREQAESFAALLKNRGGSDKAGAGAGVEGQRKAPRLVLTSAEKRKAAAAAAGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0SA72</accession>
    <name>G0SA72_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Neutral ceramidase</fullName>
            <ecNumber evidence="5">3.5.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0041230</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an N-acylsphing-4-enine + H2O = sphing-4-enine + a fatty acid</text>
            <dbReference type="Rhea" id="RHEA:20856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="EC" id="3.5.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the neutral ceramidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.23" evidence="5"/>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694529.1">
        <property type="nucleotide sequence ID" value="XM_006694466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SA72"/>
    <dbReference type="STRING" id="759272.G0SA72"/>
    <dbReference type="GeneID" id="18258161"/>
    <dbReference type="KEGG" id="cthr:CTHT_0041230"/>
    <dbReference type="eggNOG" id="KOG2232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011300_0_1_1"/>
    <dbReference type="OMA" id="WTQVRSD"/>
    <dbReference type="OrthoDB" id="191371at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017040">
        <property type="term" value="F:N-acylsphingosine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2300:FF:000004">
        <property type="entry name" value="Neutral/alkaline nonlysosomal ceramidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2300">
        <property type="entry name" value="Neutral/alkaline non-lysosomal ceramidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006823">
        <property type="entry name" value="Ceramidase_alk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038445">
        <property type="entry name" value="NCDase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031331">
        <property type="entry name" value="NEUT/ALK_ceramidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031329">
        <property type="entry name" value="NEUT/ALK_ceramidase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670">
        <property type="entry name" value="CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670:SF20">
        <property type="entry name" value="NEUTRAL CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04734">
        <property type="entry name" value="Ceramidase_alk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17048">
        <property type="entry name" value="Ceramidse_alk_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409411" description="Neutral ceramidase" evidence="6">
        <location>
            <begin position="25"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase N-terminal" evidence="7">
        <location>
            <begin position="61"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase C-terminal" evidence="8">
        <location>
            <begin position="589"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="512"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="554"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606823-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606823-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS19644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="751" mass="81469" checksum="41D8C8873E54259C" modified="2011-10-19" version="1">MASTISAISLFLLALFALAHFSSSVQGPNRHVARLAKRFDPVEHDTPIVPKASAAAAGDKYLLGVGKADITGPVVEINFAGYADTEQRGTGLRQRIYCRAFIIGQVGKPENRFVYLVLDTMSGDTAVRNGILEGLAKLGSEYAVYGRNNVAVTGTHSHSGPGGWFNYLLPQITSFGFDKQGYQAIVDGAVLAIKRAHESLQEGYLDFGTTRIEDANINRSLYAYLANPEAERAQYPDSTDKTMTLLRFRRASDLKAIGVLTWFAVHPTSMLGNNTHVSGDNKGVAAYLFEQSVKGSDAVADGFVAGFSQSNHGDTSPNVLGAWCDDGSGQMCDFQTSTCSDGKSQKCHGRGPLFYNLDLGVSSCYELGRRQFFPAKELFHSLDSESTPVVGPTVRAFHYWNDMSYYKFPLPNGTIVQTCPAALGHSFAAGTSDWPGAFDFTQGDSGEPNNPFWSVVGGLLRTPSHAQKACQAPKPILLDVGEMTTPYAWTPNIIDVQTLRVGQFFIIVSPSEVCTMAGRRWRNAVKAAAQEAGMTGDTEPYVVIAGPANTYAHYVTTPEEYAVQRYEGASTLYGQWELPAYINLTLRGLPYLAPTATGSPPAGPTPPDNRAKSLSFITGVVMDGTPIGKSFGQCIKQPSSSYSRGAVVSATFQGANPRNNLRLEGTFAAVEKLGADGKTWTRWLDDKDWRLVYTWKRTNGALGYSEVTITWETDVDLDPAGTYRIKYYGDQKPLIGSIKAFEGTSNSFTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAD4</accession>
    <name>G0SAD4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydantoin racemase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0041880</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HyuE racemase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694591.1">
        <property type="nucleotide sequence ID" value="XM_006694528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAD4"/>
    <dbReference type="STRING" id="759272.G0SAD4"/>
    <dbReference type="GeneID" id="18258226"/>
    <dbReference type="KEGG" id="cthr:CTHT_0041880"/>
    <dbReference type="eggNOG" id="ENOG502RZ0H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053002_1_1_1"/>
    <dbReference type="OMA" id="CAGMSGM"/>
    <dbReference type="OrthoDB" id="412018at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047661">
        <property type="term" value="F:amino-acid racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052186">
        <property type="entry name" value="Hydantoin_racemase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053714">
        <property type="entry name" value="Iso_Racemase_Enz_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28047">
        <property type="entry name" value="PROTEIN DCG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28047:SF5">
        <property type="entry name" value="PROTEIN DCG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="28233" checksum="BB4C10B124B5134A" modified="2011-10-19" version="1">MSSISNPPLHPSILLLNPNSSESMTLGILEAAEKMHLPQRIHLSAYTAPPSSPRSINDGSDLELSTEVVYNDIKSKTLLSAHDAILVACFSVHPLVKALSSLSTNNKPIITGIFESSILTCLSLLSPTGKWGIVTTGQFWEFHLTSGVNSFLGITDPHASNAKFAGVESTGLNASDFHGGVSQEEIRHRLREATRRLLRKGNIECVVMGCAGMAGLEEIIREVAQEEYGEKGKEVCVVDGVRAGVSVLEQAVRSRRAFRGVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAL6</accession>
    <name>G0SAL6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative tata-box binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0042720</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="9 10 11" key="2">
        <citation type="journal article" date="2023" name="Nat. Struct. Mol. Biol." volume="30" first="640" last="649">
            <title>Structural basis for TBP displacement from TATA box DNA by the Swi2/Snf2 ATPase Mot1.</title>
            <authorList>
                <person name="Woike S."/>
                <person name="Eustermann S."/>
                <person name="Jung J."/>
                <person name="Wenzl S.J."/>
                <person name="Hagemann G."/>
                <person name="Bartho J."/>
                <person name="Lammens K."/>
                <person name="Butryn A."/>
                <person name="Herzog F."/>
                <person name="Hopfner K.P."/>
            </authorList>
            <dbReference type="PubMed" id="37106137"/>
            <dbReference type="DOI" id="10.1038/s41594-023-00966-0"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.80 ANGSTROMS)</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694673.1">
        <property type="nucleotide sequence ID" value="XM_006694610.1"/>
    </dbReference>
    <dbReference type="PDB" id="7Z7N">
        <property type="method" value="EM"/>
        <property type="resolution" value="5.10 A"/>
        <property type="chains" value="D=1-255"/>
    </dbReference>
    <dbReference type="PDB" id="7Z8S">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.90 A"/>
        <property type="chains" value="D=1-255"/>
    </dbReference>
    <dbReference type="PDB" id="7ZB5">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="D/G=1-255"/>
    </dbReference>
    <dbReference type="PDB" id="7ZKE">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.60 A"/>
        <property type="chains" value="D=1-255"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAL6"/>
    <dbReference type="EMDB" id="EMD-14534"/>
    <dbReference type="EMDB" id="EMD-14562"/>
    <dbReference type="EMDB" id="EMD-14584"/>
    <dbReference type="EMDB" id="EMD-14762"/>
    <dbReference type="SMR" id="G0SAL6"/>
    <dbReference type="STRING" id="759272.G0SAL6"/>
    <dbReference type="GeneID" id="18258310"/>
    <dbReference type="KEGG" id="cthr:CTHT_0042720"/>
    <dbReference type="eggNOG" id="KOG3302">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060161_1_0_1"/>
    <dbReference type="OMA" id="NCEYEPE"/>
    <dbReference type="OrthoDB" id="2127950at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04516">
        <property type="entry name" value="TBP_eukaryotes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000001">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000002">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9 10 11" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="28"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS19788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="7Z7N"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="7Z8S"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="7ZB5"/>
        </source>
    </evidence>
    <sequence length="255" mass="27231" checksum="3356BAFC0754E4F7" modified="2011-10-19" version="1">MEAIQTHPANAAQAKAFTAPGSLSFPGGASEIANSTAPTNGASNGGQQQGVQATSGAGVTPATPAATPGAGPAGPSGITPTLQNIVATVNLDCRLDLKTIALHARNAEYNPKRFAAVIMRIREPKTTALIFASGKMVVTGAKSEDDSKLASRKYARIIQKLGFNAKFTDFKIQNIVGSCDIKFPIRLEGLASKHHNFSSYEPELFPGLIYRMIKPKIVLLIFVSGKIVLTGAKVREEIYQAFEMIYPVLQDFRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAN2</accession>
    <name>G0SAN2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0042880</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694689.1">
        <property type="nucleotide sequence ID" value="XM_006694626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAN2"/>
    <dbReference type="GeneID" id="18258326"/>
    <dbReference type="KEGG" id="cthr:CTHT_0042880"/>
    <dbReference type="eggNOG" id="KOG2137">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008724_1_0_1"/>
    <dbReference type="OMA" id="MAHKCIP"/>
    <dbReference type="OrthoDB" id="79687at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14011">
        <property type="entry name" value="PK_SCY1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF6">
        <property type="entry name" value="SCY1-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="692"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="734"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="786"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="866"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="994"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="734"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="744"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="786"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="808"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="887"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="994"/>
            <end position="1019"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS19804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1030" mass="109514" checksum="7B33B348F54DF69A" modified="2011-10-19" version="1">MFANALKTFAASNISANYSISSNLTAVAGPWKIYPAKNKKTGKECSVFVFDKKGLLDAHRAGLRGAEAAEAKRAAEVVVERLKKEALALARLRHPGILEVVEPVEETRGGGLQFVAEAVTASLSGLLQEKDDQERGGTTGRASRYVTEEPDGTRRRREIEIDELEIQKGLLQISKALEFLHENAGLVHGNLTPDAILVNAKSDWKLAGLAFCSPADSSNAHSSSIPPINLREALRHVPSLPRSVQLNLDYTSPDFVLDNNITPAADMFSMGLLCIALYNSPHRSPIECHGSLTSYQRIFQSSSSIPNSSNNFLSSRKLPKELANHLLPRLITRRPAQRMNATEFQQSEFFNNTLVATIRFLDTFPAKTMADKTKFLRGLVNVLPSFPKSVMEKKILPALLEELKDKELISLILHNVFKIISLLPSGRRAFGDKVRPALKEIFVTNVKHEPGKEREKDPARDAGLMVVIEQLGVIGENCNGKEYKDDILPIIFSALDSGTPSLVDAALQSVPNILPQLDFSTIKNELFPVIATIFSRTNSLAIKIRGLQAFVTLCGGSNDPGDDGLDGLSPQNKKATSSTALDKFTMQEKIVPLIRNIKTKEPAVMMAALKVLRVVGRIADADFVAIDILPILWTMALGPLLNLKQFQAFMELIKELSGRVEEEHSRKLAELARGDPTSPAVKDDFMSFGPPATVGSQLDANGTSETDFESLVKGSSGAGAGANPLDVGLESLASPTGSVSSKRSTPAPTFSWSTAPAAAAPASSTQKGAFRSVTPDLSHIQPIAPATTQFSQPLQPTSVGSTEPKPPTSTFSSSFSTVTTQPSTTGSTSIDWSAATKTSASNIWSTPSTTSTTTNTLASSLGSLSLNPQAHQKTGTSSFSLPPPPGSTTTTTGTARSGLSSFSLAPPPGSNLNKKPSASSFGGLGSLNASATGSGLNSLNSLNSLKNLSTSTSTSTGMGMGMGMISSSNSGFGTTMAGGMSLSMQPLQPMNVSGGSSMMGMGMDSGFGQSHGQQQQQSQKTGLDKYESLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAP0</accession>
    <name>G0SAP0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-1,2-mannosidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0042960</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694697.1">
        <property type="nucleotide sequence ID" value="XM_006694634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAP0"/>
    <dbReference type="GeneID" id="18258334"/>
    <dbReference type="KEGG" id="cthr:CTHT_0042960"/>
    <dbReference type="eggNOG" id="ENOG502QR5Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003690_4_1_1"/>
    <dbReference type="OMA" id="DFTGNTY"/>
    <dbReference type="OrthoDB" id="449263at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000010">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2080.10:FF:000001">
        <property type="entry name" value="Alpha-1,2-mannosidase subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.60:FF:000002">
        <property type="entry name" value="Glycosyl hydrolase family 92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.60">
        <property type="entry name" value="alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1610.10">
        <property type="entry name" value="alpha-1,2-mannosidases domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2080.10">
        <property type="entry name" value="GH92 mannosidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF42">
        <property type="entry name" value="PUTATIVE SUBFAMILY (AFU_ORTHOLOGUE AFUA_6G13760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92 N-terminal" evidence="3">
        <location>
            <begin position="69"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92" evidence="2">
        <location>
            <begin position="332"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS19812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="867" mass="97345" checksum="B2F72A2507187FF7" modified="2011-10-19" version="1">MGTEDSPYHKALMAVPVSLRGMPRSPRVIVYTLAFIAIFYSIPWLNLGSRDGIIPPLFQRRPRYDVLQYVDPLIGTANGGHVFPGATLPYGMAKPVADTQSPGENAAGYVSDTNPILGFSHLHDSGTGGNPSLGNFPLFVHPGCANDDYRACRFAVNNRPVYRIPDQVFASPGYFAINLTNTVRAEMTASQHVALYRFGFSGKEKVDTLEGRGIPYSPLVLVDLVDLMNSRSAGGVQVYPESGRIVGDGQYSPSFGTGRYQAFFCADFKGARIRRSGTFIGDDAREEPKFFGGHEPGWNNPSGSAGAWVQFERPEGDELLVRVGVSFISVDQACENAEREIGDWDFERVEGEARTAWRKKLGAIEIDPRGVSDELQVTFWSGLYRSMLSPQNYTGENQLWNSTEPYYDSFYCIWDSFRAQHPLLTIIDPVAQTEMIRALVDIFRHEGKLPDCRMSFSKGFTQGGSNADIVIADAWVKNLTANIDWETAYEAVVSDAEIEPPEWGIQGRGSLVSWHKLGYIPWDDKDVNGTGPMSRSVSRGVEYAYDDFCIAQLAEGLNRPADAHKYRLRGANWQNFWNPDQLDLPSPEKTQYRNPNDPSSYSDLVPLTGFKGFLQPRLRNGTFRHQPVRTCSPVSDFHSCYFDTVYDTYEGSPWLYSFFAPQDMATLIRLMGGRDTFVSRLAYFHESGIAYMGNEQAFLPTFQFHYAGRPGMSSYYVRKYIPSLFNASVNGIPGNDDCAMGAFTAFAMMGFFPVAGQDVYLLTPPFFREVRIKAWEEGKWAVIRVRNFDERGRRIYVREAWLNGRKYTRNWITHGFFRKGGVLEFVVGEEEGDWGTREEDVPPSYPVKEWVPSRGMSPEELAAELAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAT7</accession>
    <name>G0SAT7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0047730</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695139.1">
        <property type="nucleotide sequence ID" value="XM_006695076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAT7"/>
    <dbReference type="STRING" id="759272.G0SAT7"/>
    <dbReference type="GeneID" id="18258811"/>
    <dbReference type="KEGG" id="cthr:CTHT_0047730"/>
    <dbReference type="HOGENOM" id="CLU_509963_0_0_1"/>
    <dbReference type="OrthoDB" id="4587051at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="534" mass="59684" checksum="CBA2B85A2DF2AFAD" modified="2011-10-19" version="1">MRLLFLDSTKYILKGLEKCSEVLGQIHEDFIETVNQKEIQIYTFQEGRGISSIKGLHNKIVDDFSSRLHLPSSLETVATIDANHQDIVRCSDRNDPQDRSIFGAIDQLLNQLMNDTTMASHRPMSRGPVASEEEFNPRKKVSEAGNRQLVPSKENPRAAQPPQASQAAGAASEPPAGAAETFVPGTNAGTQAIGSFQVKFGNIDAQGGTVLILGNGTYVSNVAGAHVQGIQGVKGAKPETTPERRLGPHYIIREPKNTEFVGREPILTQLMEMLYDTQQAYRAVIVGTPGVGKTQVALQLSYSIKDRKWLLVVDIADDAQAVFGSTEIPTSSSQYRGIWQYLPWEDKGRMVLFTTRFWEVAWAAANSGRNVLKLGVMSKEEATQLLRSLIHKDEGDSDDFQTNGAELVRELEYLPAAIKVAAGYIVTNYITVGTYLEHLRHVLPKPYWENYWTWRPLLPHAMHILWESKGNYGVERATLLARVGDAFKTDSRWSEAIECYEELGLHKPFEVNHDKPTKNYGPKITLYFSHHRHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAU3</accession>
    <name>G0SAU3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">GPI mannosyltransferase 1</fullName>
            <ecNumber evidence="13">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">GPI mannosyltransferase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0047800</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly. Required for cell wall integrity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the PIGM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="13"/>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695145.1">
        <property type="nucleotide sequence ID" value="XM_006695082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAU3"/>
    <dbReference type="STRING" id="759272.G0SAU3"/>
    <dbReference type="GeneID" id="18258818"/>
    <dbReference type="KEGG" id="cthr:CTHT_0047800"/>
    <dbReference type="eggNOG" id="KOG3893">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024220_1_0_1"/>
    <dbReference type="OMA" id="LINCWIL"/>
    <dbReference type="OrthoDB" id="1741594at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990529">
        <property type="term" value="C:glycosylphosphatidylinositol-mannosyltransferase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051751">
        <property type="term" value="F:alpha-1,4-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007704">
        <property type="entry name" value="PIG-M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886:SF0">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886">
        <property type="entry name" value="PIG-M MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05007">
        <property type="entry name" value="Mannosyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 13" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="185"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS19323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="371" mass="41312" checksum="DFD20BF7843D3EC2" modified="2011-10-19" version="1">MASKTPSKPTTLSLLTRFLTPRYPLYLSSLLLRLILLLYGLYQDAHSPLKYTDIDYLVFTDAARFVAHGPSALGPYERETYRYTPLLAWLLLPTAYNNMGFGKVVDVAMFSFGKILFAAADLAAGWLLERVLMREGGMDGVKARKYAAVWLLNPMVATISTRGSSEGLLGVLVMALVTTVVEKRVVVAGVLLGLGVHFKIYPFIYAFAVVWWMDRERMGETTKKTSWVGKAIGFVTPERVLLGVVSLATFLALNAVMYTLYGFPFLQHTYLHHLTRLDHRHNFSPYNTQLYLSSSLPPSSASLKPESLAFIPQITLSCIFIPLTLAKSHLPTAMLAQTFAFVTFNKVCTSQETIGESMVLNRMPEDLPSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G0SB72</accession>
    <name>G0SB72_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0049130</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695274.1">
        <property type="nucleotide sequence ID" value="XM_006695211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SB72"/>
    <dbReference type="GeneID" id="18258951"/>
    <dbReference type="KEGG" id="cthr:CTHT_0049130"/>
    <dbReference type="eggNOG" id="ENOG502QWM5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034486_0_0_1"/>
    <dbReference type="OMA" id="SWRMTTP"/>
    <dbReference type="OrthoDB" id="3364892at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF26">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G07710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="183"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS19452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="505" mass="55570" checksum="1853D7B585DA8E56" modified="2011-10-19" version="1">MSGKNTPDAVVPPGADPPTFDKTPPTTNAATAASAASVRALTSQAIAFYFRAPVKAFFRTRVDYLAYARALQEQELAERRRRRRGSIGGKTVPSSSPSSTVSSVSSSQTSWLRWIRARLRATTPGVLASAVRHYGWRVVPDQVLPPLIANVGVGALLYTTYLHVLGYLHPESAIPSRRVYPPPGPGDTFAAGLVAGAIQSVVAAPLDAVQARWDVGRSAAGMTGSGNPTIGRKAPGLVGRDGQKPKSMWEFSAAKLKEIGLRGIFAGWALSFVKDSLGSAVFFSVFEYVKAQGYYNFVRWYYGSLNEDAIIMLVKKRPTPPGIIGPLEDGSSSSSSGAEDDDLPRMPRVIRPHYAIEPAFLLLAGMSASVAQQIVLHPLSHVQAEHWERLETLDQQVRRFRKRRPSYSGGTSSSSKSSPWAPWNWRKTLKANRDAYKVTWDRCVAEAKATGLGMRRWLYRGFWWNTIRQVPSTSAGLIIFELFRRKYGLTDQVRINRDGYDILLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBJ4</accession>
    <name>G0SBJ4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0053790</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695715.1">
        <property type="nucleotide sequence ID" value="XM_006695652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBJ4"/>
    <dbReference type="STRING" id="759272.G0SBJ4"/>
    <dbReference type="GeneID" id="18259417"/>
    <dbReference type="KEGG" id="cthr:CTHT_0053790"/>
    <dbReference type="eggNOG" id="KOG0381">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025284_3_1_1"/>
    <dbReference type="OMA" id="THYYQPQ"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051965">
        <property type="entry name" value="ChromReg_NeuronalGeneExpr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46040">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46040:SF3">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="5">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="119"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="119"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="201"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="417"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="345"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="431"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="482"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="526"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS18770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="576" mass="62712" checksum="C5EC3B4DE55C3AD1" modified="2011-10-19" version="1">MSQVLETIFGELGITQYLDAFLEQGFDTWETILDITESDLDALGVKLGHRRKLQRKIASYRGIAPDAALVFPTQSSVEDGKSQDAVKSENQKGDGREPVTMIVTKRKYRRHPKPDENAPERPPSAYVLFANKMREDLKGRNLSFTEMAKLVGENWQNLTPEEKEPYETQAQRCKDKYLAELAEYKKTPEYRKYQEYLKEFREKHGSPSQDKENAKRIKVEAASTTSRTSPGATPSRKTSRSGSGPESHRGSEPPTGRQRLGSVVSTAESQCSASAAPSVANHSPQESTAASPVVPVKSEQPSSRGSPTLGAVHPQPGLPLPPAHHGEDRGMQRQLPSLSDVFDNRGLSGSGRPSSSDPSNYHYSAHGHSNSDVRGPTFKSDPHYEHSSHPTSFSHPPRTAADGPLPIHALLANKPEPAFDHRQPLPMHPHQQQHHHQHHHQHHHHHSFHGNPFQASANHSDAAGGLPALNGYHNGASSATHAPPAQSHLQPLPLPSSSMHHHSASAAPSPFSASSHPQQPLRTLTPPVPPPASSSARLPPPGPSPEQGGRPGHSHSVSFDGMSALLRAGEIVDRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBM1</accession>
    <name>G0SBM1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0054070</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695742.1">
        <property type="nucleotide sequence ID" value="XM_006695679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBM1"/>
    <dbReference type="STRING" id="759272.G0SBM1"/>
    <dbReference type="GeneID" id="18259445"/>
    <dbReference type="KEGG" id="cthr:CTHT_0054070"/>
    <dbReference type="eggNOG" id="ENOG502S590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017360_0_0_1"/>
    <dbReference type="OMA" id="GKTGRNW"/>
    <dbReference type="OrthoDB" id="1162399at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="582" mass="63936" checksum="0C6E88FC6D3AF3C8" modified="2011-10-19" version="1">MALQAVYKKFLAAPNTSALADDASLHYVTTTTSIVGATEIIKHLSTVRNRINKKKEDALSAVEGGNVLVFEAETILEFVSSGGPYLPGMDDNFLADRVVTLPIIHIVTFNSDGKITQIRQSWDQGCLLKQVEVIGRSGANWPIRDAKEQINLITKCVQGQGAAAAATQTLPTRSRGGSTNAMRDPHATLELFAPREELESTPATVVSPYAGRRPRQRSFTEILGDEPQDPESPTDGRNRSESPSKASVSRTRPRQRSFTEILGDEPVDEPGSPSEGRGRSHSPGKVIAPKVGAGKNFQPQRIFDEEVADDTPETHERKPSAGRFVRPDPKKYEHFDFDDGSETPAPPAPKPATGKKTVHESSWSFEDFTTPQKPIAMKGGHRARDIRHWGPDNELLPNTPNPNAPVPKPRRDNEAHFEFVDDGEQTEEQRSRPTRSSVHSKHLFENRLPITDDAKDDVPEKPSVKVANAKDRLKDFGAHFDLTDSSPHHNGTSEPAKVPEHRKKAVSMIQPSWAPHDESPQKENSKPGGRLGPDEHRIAIGGDGMGGKKGSSRAWFTGEDEEPAPVKKSRGPPAKSDNFWDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBN6</accession>
    <name>G0SBN6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0054220</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC7 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695757.1">
        <property type="nucleotide sequence ID" value="XM_006695694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBN6"/>
    <dbReference type="STRING" id="759272.G0SBN6"/>
    <dbReference type="GeneID" id="18259460"/>
    <dbReference type="KEGG" id="cthr:CTHT_0054220"/>
    <dbReference type="eggNOG" id="ENOG502S942">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049078_0_0_1"/>
    <dbReference type="OMA" id="QFLHNAN"/>
    <dbReference type="OrthoDB" id="205166at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008501">
        <property type="entry name" value="THOC7/Mft1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405">
        <property type="entry name" value="MAINTENANCE OF KILLER 16 MAK16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405:SF5">
        <property type="entry name" value="THO COMPLEX SUBUNIT 7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05615">
        <property type="entry name" value="THOC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="42"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="233"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="136"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="355"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS18812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="405" mass="43982" checksum="91C9BC97072A70F2" modified="2011-10-19" version="1">MATWGLLDDKEENELHKSRLLNVEEKPFKRITKRLNTLHTLAIVHARQAPTPPPETASSTAPTDGTQQASQSGESASPTPATDALLSTDLAQLKEDITLDFAAFDSSIARLQFLLTANERERDRYAAERQRIVAASQAVRNNTAQLRQQLEQARATLAQRRKFDELADAITNNPALKPRAEQAENLRKLEEEIAELEAEAEQYSVTWNERREQFARIMDESMRLRRLIRDEKEEVDRREGMDDDQGETGGSAEGGETTAGQTPRPSGAVSGNATPRPESGVPAPKSVADSGDVGTPRPVSTTGCRTPARESSVPSAAAPEGQSFLKPPTGAGASFSQAGSTAGSREVSTEREVEAEQGEVEESEDVEMIEVKDDQSEPDSPLTPPPADDAPQIVVDTQPDTMDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBU5</accession>
    <name>G0SBU5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Phosphoribosylaminoimidazole carboxylase</fullName>
            <ecNumber evidence="4 11">4.1.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0054820</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2</text>
            <dbReference type="Rhea" id="RHEA:10792"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="EC" id="4.1.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.21" evidence="4 11"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695816.1">
        <property type="nucleotide sequence ID" value="XM_006695753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBU5"/>
    <dbReference type="STRING" id="759272.G0SBU5"/>
    <dbReference type="GeneID" id="18259520"/>
    <dbReference type="KEGG" id="cthr:CTHT_0054820"/>
    <dbReference type="eggNOG" id="KOG2835">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011534_3_0_1"/>
    <dbReference type="OMA" id="ITFDHEH"/>
    <dbReference type="OrthoDB" id="15425at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01928">
        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016301">
        <property type="entry name" value="Ade2_fungi/plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054350">
        <property type="entry name" value="PurT/PurK_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609:SF5">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609">
        <property type="entry name" value="PURINE BIOSYNTHESIS PROTEIN 6/7, PUR6/7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22660">
        <property type="entry name" value="RS_preATP-grasp-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001340">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52255">
        <property type="entry name" value="N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="13">
        <location>
            <begin position="123"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS18871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="614" mass="67001" checksum="7E98C0388BE74226" modified="2011-10-19" version="1">MAESRNPVIGLLGGGQLGRMLCEAANPLGVDIAILDAENAPAKQAHNTYRHVTGSFKDPERIRELAIKSDFLSVEIEHVETEVLEDIDKNGVTLPDGSLHRPPIHPSWRTIRLIQDKYLQKEHYRNSDKKIPIADQVAIDGGAAALASLKDAAARFGFPFMVKARKGSYDGRGNYRVNSEADFEAAINALKGLSLYAEKWAPFIKEIAVMVIRTEDDRGNLKACVPYPAVETIHEDSICTKVFMPPRDISEEVCENARKLATEVVSTLWGRGVFAVEMFVLEDGSLMVNEVAPRPHNSGHYTIEAVPQMSQYKAQIHAVLDLPVPKQLSPRARSAIMLNILGGATPSSHLGLANLARTTFDDDMDVHLHLYNKESKPGRKIGHITLTSNTLSIHDLEAKAKSFIDLVDQIRRDRLAATTETLRPTQEPAKPQAAQPVPSEKPLVLVTMGSDSDLPVLKAGLDILRQFGVPYALDITSAHRTPRYMMKVADEAAARGIKVIIAAAGGAAHLPGMMSSETPLPVIGVPVKATHLDGIDSLLSIVQMPRGIPTATVGINNSTNAALLAIRILGTSIPEFFTKMKKYQEKMEEEVLTKGSKLREIGDVAYLANMAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCJ6</accession>
    <name>G0SCJ6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative polyadenylation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0057470</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696067.1">
        <property type="nucleotide sequence ID" value="XM_006696004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCJ6"/>
    <dbReference type="STRING" id="759272.G0SCJ6"/>
    <dbReference type="GeneID" id="18259785"/>
    <dbReference type="KEGG" id="cthr:CTHT_0057470"/>
    <dbReference type="eggNOG" id="KOG0108">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028601_0_1_1"/>
    <dbReference type="OMA" id="NEYEIMG"/>
    <dbReference type="OrthoDB" id="272703at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12398">
        <property type="entry name" value="RRM_CSTF2_RNA15_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.70">
        <property type="entry name" value="Transcription termination and cleavage factor, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025742">
        <property type="entry name" value="CSTF2_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026896">
        <property type="entry name" value="CSTF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038192">
        <property type="entry name" value="CSTF_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14327">
        <property type="entry name" value="CSTF2_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14304">
        <property type="entry name" value="CSTF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="8"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="87"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS19122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="294" mass="31145" checksum="EED6F8EF177FA27B" modified="2011-10-19" version="1">MSTRQPSRVVFVGNIPYGLTEEQITEIFSGAGKVLNFRLVYDRETGRPKGFGFAEFPDYDSAASAVRNLNDYEIMGRKLRVDFSNEVVGDDDNRDRDGATNNYSTSPTSSTPSTTLPPLPQGKDLPPGVHCTDAISRTLNTLPPAQLLDILQQMKTLATTDPARATELLTQAPQLSYAVFQALLIMGLVSPEAINSVLEPTAATTAASTIPGAVVPPPYGYPGATGTPVGGSPAAAPPPAAAQPAAGAAAIAQDPEALMRAVLELPQETIDQLPEVERQQIMALRASYAAQLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCQ6</accession>
    <name>G0SCQ6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative heat shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0058070</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696127.1">
        <property type="nucleotide sequence ID" value="XM_006696064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCQ6"/>
    <dbReference type="STRING" id="759272.G0SCQ6"/>
    <dbReference type="GeneID" id="18259845"/>
    <dbReference type="KEGG" id="cthr:CTHT_0058070"/>
    <dbReference type="eggNOG" id="KOG1051">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005070_4_0_1"/>
    <dbReference type="OMA" id="VSKMMQG"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000120">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000010">
        <property type="entry name" value="Chaperone clpB 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF176">
        <property type="entry name" value="HEAT SHOCK PROTEIN 78, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="120"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="517"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="9">
        <location>
            <begin position="695"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="333"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS19182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="802" mass="88653" checksum="FEF97F257D372622" modified="2011-10-19" version="1">MQARVRLASATSRRVAAASRGALRQRSQFSQTLGATTQLTTAFGNSLHVLPTAAFRAYSNGRPQPPGGTYRMNLGGEPEKPALEQFGIDLTAKARAGKLDPVIGRSAEIQRTIQILSRRTKNNPVLIGSAGVGKTAVIEGLALEIVRGAVPESIKNKRVISLDLGSLIAGAKFRGDFEERLKKVLSEVQAANGEVILFIDELHTLLGLGKAEGSIDASNLLKPALARGELQCCGATTLAEYRQIEKDVALARRFQPIIVSEPSVQDTISILRGIKDKYEVHHGVRITDGALVAAATLSNRYITDRFLPDKAIDLMDEAASSLRLQQESKPEEILRLDQKIMTIQIELESLRKEKDIASRERREKLEKDLKQYQDEVKVLMEKWEKEKAEIDAIKQTQAELDKARIELEKAQREGNFARASELRFGVIPSLEKKLPKDDVVEKEDSLIHDAVTADDIANVVSRTTGIPVNKLTSGHTERLIHMEDILRESIRGQDEALKAVADAVRMQRAGLSGDNRPTASFFFLGPTGVGKTELCKKLAGFLFSTESAVVRFDMSEFQEKHTISRLIGAPSGYVGYEDAGQLTEAVRRKPYAVLLFDEFEKAHRDISALLLQVLDEGYLTDAQGHKVDFKNTIIVLTSNLGADILVGADPLHPYKETPDGDIHPDVKKAVMDVVAAQYPPEFLNRIDSFIVFKRLSLQALRDIVDIRLRELQARLDDRRITLVASDEVRQWLAERGYDPKFGARPLNRLITTEIGNRLADKIIRGEIRTGHTAVVEIAEDGDGLTVRAEEKAESRPAEAAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCS9</accession>
    <name>G0SCS9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0058300</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696150.1">
        <property type="nucleotide sequence ID" value="XM_006696087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCS9"/>
    <dbReference type="STRING" id="759272.G0SCS9"/>
    <dbReference type="GeneID" id="18259868"/>
    <dbReference type="KEGG" id="cthr:CTHT_0058300"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010119_1_1_1"/>
    <dbReference type="OMA" id="ARETGFF"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000036">
        <property type="entry name" value="Oxidoreductase, 2OG-Fe(II) oxygenase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF812">
        <property type="entry name" value="2OG-FE(II) OXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="174"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS19205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="390" mass="43285" checksum="E7C8F6B9225E451C" modified="2011-10-19" version="1">MSFTSIPILDLSLAKDPATKPKFLEELRHALLEVGFLYLKNVGISDEFFQQVIKEGKAFFDIPEEEKLKIEMKNAPSFLGYSRLSAEITAGAIDHREQIDLSTEHPLPGPNDPRHYNLRAPNQWPSPELLPNFRPVFTEYMKRMGEISIYFTSLIAEAIGLPPDAFNKFFDKDQQHKLKIVKYPDVGTLGAAGKQGNQGVGPHKDSMLSSYLLQASHHKGLQVQNMKGEWIDCPPIDGTLVVAIGQGLEALTQGVCVSTTHRVLSPPAGEGARFSIPFFQGVSGDVTFDDLENVGIGQVPEHIKELRRKVLAENGGRLDDVEFTFRSGGHAKTLGEAILRNRVKSHQDVGERWYPDILASIREEQAKAKQQEQQKNQGVMVAQGVAVEAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDB5</accession>
    <name>G0SDB5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0051190</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695461.1">
        <property type="nucleotide sequence ID" value="XM_006695398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDB5"/>
    <dbReference type="GeneID" id="18259157"/>
    <dbReference type="KEGG" id="cthr:CTHT_0051190"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008362_1_0_1"/>
    <dbReference type="OMA" id="WTVFRCT"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="325"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="23"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS18516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="686" mass="76522" checksum="1950DF79F14E476A" modified="2011-10-19" version="1">MQTAQQVTPSQIHPSFLEVDQNAIKTDSTKSPQAMDGAAPRDSVTEGSPKKALLHQSQSPDAFSPSPHARVHEGNLDEFMQMGNDFGMQETVTYQDLMMWPDFSMELDMYPGTIPLMRTDVSMPAFPEFSDTSSSESMGTASSRSSIHTRGTSIMSTGDFDTSIKPSEFAMAALSDESIPEFEVVLAAEASWNFARCNPPSSAGSCPRTAIVHLECLEQKSKHEGTWSSLEKYLEQVEWDPSDVASVVPLTPRTRDKMLAITQSFLHKALDIHRGSLSNGGYPKASSPGDFSFLVLPPNNILEYFLRSYVRSLSVYYPLVTTCVDPNEMLQNNQASTLLFLLMIAQGAAAMPIAEARYLSAGLTETCRISLFDIVEKDIELASDPTTLRCALLFIVLGAWSGDKWLMDIAMGQRGMYMSMLKHAGFLDPQPSMPIFDGSSNTELQWRAWINRETRNRLVYNYVMLDQELSLFHDTAPFFAITELQCPLPAPEVLWMAADSEQWVNAMQSVYGCSPNISPELLGTPSITPSLYDLFQDFLQDNLSRRSPTLSAQRLRLILHPLQALLCHLRQMLSCFSESHNGRRTSTRTVTKASTLLRLEEVQSLLQKWYDLTMDYSKDHPGCPVTRCNLVLYHLIALNAVTNFPEIERLARREGLDGAGSSWELALRYKRPQKSNNPGGHRSGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDL0</accession>
    <name>G0SDL0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0052160</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695556.1">
        <property type="nucleotide sequence ID" value="XM_006695493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDL0"/>
    <dbReference type="GeneID" id="18259254"/>
    <dbReference type="KEGG" id="cthr:CTHT_0052160"/>
    <dbReference type="HOGENOM" id="CLU_1261376_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="219" mass="23973" checksum="CD263E1C901A3771" modified="2011-10-19" version="1">MVPSPNNYPWLTGPIPSIVEPKPSKPQPVEVDSIPIEPEPIRPQPIEPDTSSQQPEPIEVDEEYMRNPNAAEEDEARLRAELPRLLAKRPSAYLRRLNPRLNPKVEKMIATGDQCNVRGESSAAGPGGQQRQQHTAPNPITASSDNLADEALSNSHIYLTYLESDPDCAMPDPLTAQEDEGVSDISLGRGLEVSECCAQSPKDEEEDEDSGTERGERSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDY0</accession>
    <name>G0SDY0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycosyltransferase family 28 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0053400</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695676.1">
        <property type="nucleotide sequence ID" value="XM_006695613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDY0"/>
    <dbReference type="GeneID" id="18259378"/>
    <dbReference type="KEGG" id="cthr:CTHT_0053400"/>
    <dbReference type="eggNOG" id="KOG1192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000537_1_0_1"/>
    <dbReference type="OMA" id="SFAHIHV"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000100">
        <property type="entry name" value="Glycosyltransferase family 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000009">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF13">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase family 28 N-terminal" evidence="3">
        <location>
            <begin position="122"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Erythromycin biosynthesis protein CIII-like C-terminal" evidence="4">
        <location>
            <begin position="448"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="661"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="944"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1046"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1118"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1226"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="665"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="691"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="944"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1050"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1064"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1128"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1149"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1193"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1226"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1259"/>
            <end position="1271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS18731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1271" mass="139101" checksum="5F6B299AE03AA782" modified="2011-10-19" version="1">MPENSLPVQTNAVPMVAEELETDELDVPPPPYGDHHHQLQFSRSGFAADASVNNNGRVNIYISEKNRRLTELLAPSFKREHHARITQPHPSSPVTGEPLPPPYIPPSLGGQPGQIPPPRLNVVIQIVGSRGDVQPFVALGQVLRDTYGHRVRLATHATFKDFVEENGLEFFNIGGDPAQLMAFMVKNPGLVPGFEAIKSGDIKRRRKEIEEILMGCWRSCIEAGDGMGPPPEKGEDGKVIIPEGKRPFVADAIIANPPSFAHIHIAEKLGIPLHMMFTMPWTPTKTFPHPLADIVASTNTDSATSNYVSYALVEMLTWQGLGDVINRFRTKVLELEPVSLLGAPGLLTRLRIPATYCWSPSLTPKPADWAPEITVSGFYFLDLESNYVPDPELQAFLAAGPPPVYIGFGSIVVDDPDGLTKLIFSAIIKSGVRALVSKGWGGLGGDALDVPEGVYLLGNCPHDWLFKHVAAVVHHGGAGTTAAGIRAGKPTVIVPFFGDQIFWGNMIARAGAGPAPIPYKKLTAEKLAAAIEFALTPDVKRRAAELGESIKAEKGADVGGKSFHEFLNVESMRCSLAPSRVAVWRVRRSKVRLSALAAAVLVKEGVLKYSDLKLYRPIEYNTEERPWDPISAVTMALVGDIGAFTMALADFPREIFKGVSRKDSNTTTGTETPSSGLSPTSTFSHKRAKSNSHLSATSSSTTLVSEPPAPRPRSSHGPATSFDELLQKIPTPHQHRSPSPRPSTPKPSSDEKEPSSSNINLDLALAAGKSAARILTAGMRFTPNVCLSLARGFRNAPRLYNDETVRPQSEKVTGLATGMKVAGKEFTLGMYDGISGLVTQPLRGAEKEGSKGLIKGIGKGIGGLILKPAAAAWSLPAYVMQGVEKEMRNYWGREGMMGIVAARIKQGEEEYGLATEGEKMDVIRRWGALGEELREFWNWRRKDRERENEGNGDGEGKRGSWFKWRRSVPATPTTSGNTEGAGESQVAAWQAVVGQSQAGTVSFPFDDDAALEKAIKESVQQTSTGNAEEDAMVEAAIRASLLEMRRVHEQQQQQQQQQAQQAITRHDDPKDHSPVITDYELRNISDEEYHALIEEAIRQSMIEHQIEQARLWSAQHTNLSPTQQSSVPPSPNPAPAYAPPITTSPPLPSHTSTSASGTTPSPPRPDPMVTVPVPVVPVPNDEDEQLRLALEQSAREHREQEERQAKERSEEEIVLEYVKRQSLAEEEFRRLREQREREEESRRSIVGPSNPAGDEEDEVLRRVLEESLRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2023-02-22" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDY7</accession>
    <name>G0SDY7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0053470</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695683.1">
        <property type="nucleotide sequence ID" value="XM_006695620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDY7"/>
    <dbReference type="GeneID" id="18259385"/>
    <dbReference type="KEGG" id="cthr:CTHT_0053470"/>
    <dbReference type="HOGENOM" id="CLU_1959318_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS18738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="128" mass="13586" checksum="42A116EC98E4541E" modified="2011-10-19" version="1">MKKPPVRQPAEALGWWQALYGAIVGPGGPMLKLAANWHDVKGAPHTLVCPVLNPAEAYEPGGCPGVRMETSSRAQTQPGTFQVPGLPDEPGYGFASAISAIVSPRAPAPTISSRQPWWVRILPQPDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0SE19</accession>
    <name>G0SE19_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative low-temperature viability protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0062110</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LTV1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696527.1">
        <property type="nucleotide sequence ID" value="XM_006696464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SE19"/>
    <dbReference type="STRING" id="759272.G0SE19"/>
    <dbReference type="GeneID" id="18260249"/>
    <dbReference type="KEGG" id="cthr:CTHT_0062110"/>
    <dbReference type="eggNOG" id="KOG2637">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028555_1_0_1"/>
    <dbReference type="OMA" id="TAQHFTL"/>
    <dbReference type="OrthoDB" id="5852896at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007307">
        <property type="entry name" value="Ltv1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21531">
        <property type="entry name" value="LOW-TEMPERATURE VIABILITY PROTEIN LTV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21531:SF0">
        <property type="entry name" value="PROTEIN LTV1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04180">
        <property type="entry name" value="LTV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="212"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="282"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="308"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS18196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="445" mass="49719" checksum="D9E5C845DD44372E" modified="2011-10-19" version="1">MAKGKWIDKKTATHFQLVYRPQNDPLIHDENAPQMVLNPTQPPNSKGKGKGKTLSELASELGDDVRSVRANEGEAANYGIFFDDTEYDYMQHLREIGTGEGEAVFIEANPVINRGKKGGKQKQSLEEALRQLDLKNKSEELLDPEILPNKNLQHVSYQAQQDVPDEIAGFQPDMDPRLREVLQALEDDAYVDEEGGEEIFQELAKDARELSQDEFEETFDDFEEDEGWESDRTVKAEKKPEPAQTGDGDAQPASDTKPGQQTSGDTAEGEVPPEATSDAWMEEFKKFKSDQKAAERKSAKARAAPSEIQSSIWTVTTNGGRRKHRKGALTNPSTYSMTSSSLLRTEQLSILDARFEKLEEEYNAEYDEMASMSAVSTASTVQGPTRQDFDGLLDEFLDNYQMAGKKRVKKGKLSGVEQFDEIRRELGPPRIPAKYLGKGKGKARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0SE46</accession>
    <name>G0SE46_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0062390</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696554.1">
        <property type="nucleotide sequence ID" value="XM_006696491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SE46"/>
    <dbReference type="GeneID" id="18260277"/>
    <dbReference type="KEGG" id="cthr:CTHT_0062390"/>
    <dbReference type="eggNOG" id="ENOG502S606">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041168_1_0_1"/>
    <dbReference type="OMA" id="AHIKTED"/>
    <dbReference type="OrthoDB" id="5364312at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42111">
        <property type="entry name" value="YALI0D23727P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42111:SF1">
        <property type="entry name" value="YALI0D23727P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="393" mass="40385" checksum="06FCCE403B23A864" modified="2011-10-19" version="1">MTASGSAPSQGSQPAPKVAEPSGSDSGTGTSTARPAAPEAEEKKKKRSLFGFGKKRAEESTKPSSKEAAKPTSNKPPSALAQTTATTNRSTATSSAQPEHPYFSPSSPGRPGFPSSPRISSPASSQIFERDVQETGSILIPNSPAIPSHIQTENYIPPVLDASSEAITDNHLDPDNVEIITHASHQPIGVGLAAATSSALSSPHEPPAHSSWTDELAAFSARRYPADSASNYGSLADTTDVRRLSFISFADVVQAEQQQLREQLSGGEPGSRESTHLIAGLTSLNINSSSSPRNRSPSPVRSPVSSAGSKSGSVTGVDLSPRLHPTVPAAAGKQSLGSPTNLGPGGSGLPPAPVVTGEIAVETMAQALRRTGSGDLSGYPHVASVRSFPVSPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEY2</accession>
    <name>G0SEY2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inosine/uridine-preferring nucleoside hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0060110</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS17998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696329.1">
        <property type="nucleotide sequence ID" value="XM_006696266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEY2"/>
    <dbReference type="STRING" id="759272.G0SEY2"/>
    <dbReference type="GeneID" id="18260049"/>
    <dbReference type="KEGG" id="cthr:CTHT_0060110"/>
    <dbReference type="eggNOG" id="KOG2938">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036838_9_0_1"/>
    <dbReference type="OMA" id="RNVVSMF"/>
    <dbReference type="OrthoDB" id="5783963at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008477">
        <property type="term" value="F:purine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006152">
        <property type="term" value="P:purine nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.245.10:FF:000006">
        <property type="entry name" value="Inosine-uridine preferring nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304:SF56">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G11790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="INOSINE-URIDINE PREFERRING NUCLEOSIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="4">
        <location>
            <begin position="7"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS17998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="434" mass="48371" checksum="71D66BA58F551E92" modified="2011-10-19" version="1">MAPKNRIIIDTDPGVDDVLALLLALSASPEELEVLMISVTYGNVPRQKCLRNVVALFHVLEKEMAWREANGKPVYGALNAYKPIVAVGAEHALEDEELVADYFHGSDGLHGVHDKHPHLSPAETWRTLFEDNGSVPISEPPTFSRYFTPSKTPSYKEMLRILREEPEDSVTIVCVGPLTNVALAAAEDPETFLRVKELVVMGGAVHVEGNVTPYGEFNCTADAIAAARVYALTSPTPSSTMPPAFSEKSLPPYPEKLSRRLKLTLFPLDITTPHELFREQFNAKVMPLIEAGSPLAQWTETFLTGTFNKIDQMLGEGHNEGLSLHDPLCVWYMLTHDDPKWKTVPKPEDIRVETCGQWTRGMHVIDRRNRARPDESTIETHPQDPIEAVTVKLDEVPGDKMGWLSPRKGNRINRMVQSPGEKIFADVLLNKIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0SF65</accession>
    <name>G0SF65_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0060960</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696412.1">
        <property type="nucleotide sequence ID" value="XM_006696349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SF65"/>
    <dbReference type="STRING" id="759272.G0SF65"/>
    <dbReference type="GeneID" id="18260134"/>
    <dbReference type="KEGG" id="cthr:CTHT_0060960"/>
    <dbReference type="eggNOG" id="KOG4231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_144_2_1"/>
    <dbReference type="OMA" id="MINMATS"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="4">
        <location>
            <begin position="21"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS18081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="311" mass="34147" checksum="5B9794147E013662" modified="2011-10-19" version="1">MLGRLRMSTQEALQEYDNCAAAVFSCKNIKNPTAWFRASGLKKVVEELVAKRGMGDLMQEENPPNKGKVLVCVMPTKSWGEARIIRSWEPSDPDSRWHKNTTIWQAARATTAASIYFKPEVLGNGKEDQPFIDAAIGANNPVEYLLKEAVRHFGSGKPLGCVVSIGTGTREVEIASPPKGLLKGWINPLPYVASVAKLLKTSATDPEHAHRSIAYRVEGYPGAYFRFNVTNAAAVVGLSQYKKIPELKSLTVKYLSDPDIIAKIREAADKLRGEAFDHGLSLGYVSMSSLDLLNNAYFMIVSAKTKRSSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFA7</accession>
    <name>G0SFA7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0061380</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696454.1">
        <property type="nucleotide sequence ID" value="XM_006696391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFA7"/>
    <dbReference type="GeneID" id="18260176"/>
    <dbReference type="KEGG" id="cthr:CTHT_0061380"/>
    <dbReference type="eggNOG" id="ENOG502RMMX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1023083_0_0_1"/>
    <dbReference type="OrthoDB" id="3525430at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="272" mass="30937" checksum="D45BFC7E75D888DC" modified="2011-10-19" version="1">MSTTRDSNLTQSIPAQWQIYPSIPTECPRRRDTFIAFAITNLVTMVLGLAVGCRPFIYIISCRMFGKKKRKNVYWYNWLPTWGLTFVGNVLCAVLIMRTPGYEHIRVADVAMLYLQRPRITLLALTTVTYAIVWKGEMPWIRAWVATAGAELLLQIMAAIWVVRAGEGYLNQRHILAIAIWEWVNAGLTAIMAIYIVRCWRNQVAHAEAVDEAAKYPNGFVMQNDFWVQNGFSERQAVPKVKRLTFRVWLILMVIGGLGYAGVGAHQNLGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFF3</accession>
    <name>G0SFF3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0061840</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696500.1">
        <property type="nucleotide sequence ID" value="XM_006696437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFF3"/>
    <dbReference type="STRING" id="759272.G0SFF3"/>
    <dbReference type="GeneID" id="18260222"/>
    <dbReference type="KEGG" id="cthr:CTHT_0061840"/>
    <dbReference type="eggNOG" id="ENOG502SFQA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021365_1_0_1"/>
    <dbReference type="OMA" id="WFRTPPD"/>
    <dbReference type="OrthoDB" id="5379885at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="485"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="624" mass="68155" checksum="BA0D8E23C2F544AD" modified="2011-10-19" version="1">MEGALTVPPDRTIIGRAAWKEDVEPIQQFSVTSIADCQVQTLAHRKQGPPLPTLVINILPDPVLDKLRKRRSSRTATFSSSSRDTSPTTLMFRPGDERYTLNDWARFIQQFIQPQLLDRVPMSPITPGSPSFINPFAPRRELSDTQFKPESGSESSRQTFYPKSAGQAYPPRDRPVTFSDTPSLRSKRSDLSSQTSVTQPPVSLHSYGSIVPAELPSPATTIGEYQGDFIEGWTSAQGRSSALSSPVRGRDSVSSQPPSSLPPIADPPGPRETILDRAFQLRRIPGSENTNPGDEKMSSLARFDALMAELEEKRKKREAEEAKLRGETAPPPQPAPETQAPQSAWDSDTDDDSDGFVGEGERDIEDRFSMPETSIRRAPDYVSERCEPPPKNPARARRAPPAYNHEALMALSGNGPSSRPQTGYSKSRSNRPSMSQRTHSQPHLATILASSARRDGAVPFPAYAENDDTFSSITSSPPATRLHRSSTTTGTTSSLTPHHEKRLSTSSSKRLSFSEFTRRLSSSTSSLLIVQSNTSGKDGSAASGRATPSSTRQSIVSDGADHHSLIAPQSPPQHLHHLHPRAGSLSAHRERALEREQSAASERAERYGWRGSVGVFGAPEGNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFZ6</accession>
    <name>G0SFZ6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alternative oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0072710</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697529.1">
        <property type="nucleotide sequence ID" value="XM_006697466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFZ6"/>
    <dbReference type="STRING" id="759272.G0SFZ6"/>
    <dbReference type="GeneID" id="18261309"/>
    <dbReference type="KEGG" id="cthr:CTHT_0072710"/>
    <dbReference type="eggNOG" id="ENOG502S5IM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026659_0_1_1"/>
    <dbReference type="OMA" id="CPQITIY"/>
    <dbReference type="OrthoDB" id="20368at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11296">
        <property type="entry name" value="O-FucT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS17911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="51602" checksum="7B04118FE0FF0EE0" modified="2011-10-19" version="1">MVLVGVSGFGRPRILILVLLALLILIWSPRLSKPRLLCFHPGCYYNDPHLLSPPKQTVDLSKADAPFIPWPLARVCAEANHWTPGVVFICDNNSGGIGNIRNYILTCIRYAIEAGATAIVLPQIRTRSAEDLSNIMLPHEPFTYFFDEAHFRRSFAIACPQITIYNSTSDIPHAPVPFKPEQITPHNFGKRGGCDKRELNKHTDRFGVQFAAHIENTTQEFHLPPPSPEHPRIIRFTWGVQFDWPVFRDGPEFVATFGGLLRFRQDILDLGYRTASYMRQFASSQDGASTSKYIGIHLRTESDALPRWPKYDDQATAYLERAGAMSFKAAYLATGNRTEAKRLADAAEKEHGMAVITKHELLQHHPEDLTKLEALTWDQQALIDFIVLLESDYFLGVSPSSFSMNVALKRHLKTEGLYTRPWKIGGDGDGHSWLVGKYEHYWDDWLFMFDSMWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFZ8</accession>
    <name>G0SFZ8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial chaperone BCS1-like ATPase lid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0072730</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697531.1">
        <property type="nucleotide sequence ID" value="XM_006697468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFZ8"/>
    <dbReference type="STRING" id="759272.G0SFZ8"/>
    <dbReference type="GeneID" id="18261311"/>
    <dbReference type="KEGG" id="cthr:CTHT_0072730"/>
    <dbReference type="HOGENOM" id="CLU_2236310_0_0_1"/>
    <dbReference type="OrthoDB" id="4185654at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondrial chaperone BCS1-like ATPase lid" evidence="3">
        <location>
            <begin position="12"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS17913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="105" mass="12061" checksum="9558D1C2EF2190DC" modified="2011-10-19" version="1">MIFLGHISQRSSELMFLRMPGPDQEAASPASSINIPAEELEQLAQEFSQHIPPQTFTHAQLQGYLLNCRDSPREVLKNIESWVKEEVTLIEAAKEKEKRRSEQRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGH5</accession>
    <name>G0SGH5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA polymerase</fullName>
            <ecNumber evidence="13">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CTHT_0066350</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the DNA polymerase type-X family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="13"/>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696932.1">
        <property type="nucleotide sequence ID" value="XM_006696869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGH5"/>
    <dbReference type="STRING" id="759272.G0SGH5"/>
    <dbReference type="GeneID" id="18260673"/>
    <dbReference type="KEGG" id="cthr:CTHT_0066350"/>
    <dbReference type="eggNOG" id="KOG2534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008698_4_1_1"/>
    <dbReference type="OMA" id="QEGWITH"/>
    <dbReference type="OrthoDB" id="205514at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00141">
        <property type="entry name" value="NT_POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.210.10:FF:000005">
        <property type="entry name" value="DNA polymerase IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000010">
        <property type="entry name" value="DNA polymerase lambda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.110:FF:000005">
        <property type="entry name" value="DNA polymerase POL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="entry name" value="DNA polymerase, thumb domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028207">
        <property type="entry name" value="DNA_pol_B_palm_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018944">
        <property type="entry name" value="DNA_pol_lambd_fingers_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022312">
        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002008">
        <property type="entry name" value="DNA_pol_X_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276:SF29">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY PROTEIN POL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14792">
        <property type="entry name" value="DNA_pol_B_palm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10391">
        <property type="entry name" value="DNA_pol_lambd_f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00869">
        <property type="entry name" value="DNAPOLX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00870">
        <property type="entry name" value="DNAPOLXBETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81585">
        <property type="entry name" value="PsbU/PolX domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="15">
        <location>
            <begin position="91"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="77"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="196"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGS17314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="626" mass="70242" checksum="FB6DB01DE28F2EB0" modified="2011-10-19" version="1">MSALDHPNSLARTLNFPIIFLLPTHLSADELEELEEQIPTLTNDINEAEVILGKIFRKERALFELRKLKLATEEIQRTGDERPTARSPAHKRAKLTRSVTHSSGIGSDTLDSDTTASVSDAEIQRRLAGPGPAEQTVRVVRLAWFTESIKAGKVLPTRDYLLYEGRKLRAAPAKQREKTSPASSEKSVEVMKRARADAEFSPGEGFRPPSSQGRRGETYSSHPVKRPPLVRQTTSEHEIDTQLPPIPDYLHTTYSCQRPTPVNPPNESFIKELEKIKTARTLMGDRIGVRAYSSAIATIAAYPYAFKTAQEVARLPGCGAKIAQLFQEFKDTGQIAEANEDDSNPRLAVLKLFYEIWGVGETTARSFYNRGWRDLDDIVEYGWDSLTRVQQIGVKYYDEFKQGIPREEVERIANTILEHANALHPGFEMVIVGGYRRGKLKSGDVDVVLSHRDENATHNFVERIIVRLEEAGYITHTLTLSTANSERGQIPVNWKGDDRRGAGTGFDTLDKALVVWQDPVWTTGEKKNPNPHRRVDIIISPWKTVGCAVLGWSSGTTFQRDLRRYCKRERALKFDSSGIRSRVDGSWVDLESGPNGEPAPDMLTAEKRVFEGLGLVWRPPEERCTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGM5</accession>
    <name>G0SGM5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative 37S ribosomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0066870</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696982.1">
        <property type="nucleotide sequence ID" value="XM_006696919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGM5"/>
    <dbReference type="STRING" id="759272.G0SGM5"/>
    <dbReference type="GeneID" id="18260725"/>
    <dbReference type="KEGG" id="cthr:CTHT_0066870"/>
    <dbReference type="eggNOG" id="KOG0876">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057349_1_0_1"/>
    <dbReference type="OMA" id="MTAREPN"/>
    <dbReference type="OrthoDB" id="275227at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S26, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="2">
        <location>
            <begin position="134"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="2">
        <location>
            <begin position="250"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="308" mass="34364" checksum="02C4C57D775BD15E" modified="2011-10-19" version="1">MIRPRLRISSAARPRLAVPIQAARPSFAQQIRSRHTLQPLPYEEKFNTAENGIPNFLSGPAFNIAWTQYQTHLIEKLNTMIADTDFEARQVKDILLMTAREPSQAPLFNYASMIHNNAFFFKHLSPEPVAMPEHLKLHLEQSFGSIETLRREMVYTAAAMFAPGFVWLVKSPQLGLPHAFRILTTYAAGSPYPAAHWRRQPVDMNTAAGMNDEQGLATAQGYIENAAFGAGKSNPAVASKLKFAPGGTDVQPVLCINTWEHVWLWDYGFGAGGQGGKLAYAEAWWNAINWEMVANEANIKRHQMTGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGV1</accession>
    <name>G0SGV1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Checkpoint protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0067670</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the HUS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697058.1">
        <property type="nucleotide sequence ID" value="XM_006696995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGV1"/>
    <dbReference type="STRING" id="759272.G0SGV1"/>
    <dbReference type="GeneID" id="18260805"/>
    <dbReference type="KEGG" id="cthr:CTHT_0067670"/>
    <dbReference type="eggNOG" id="KOG3999">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035754_0_0_1"/>
    <dbReference type="OMA" id="VCWMRLE"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044778">
        <property type="term" value="P:meiotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016580">
        <property type="entry name" value="HUS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007150">
        <property type="entry name" value="HUS1/Mec3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900:SF0">
        <property type="entry name" value="CHECKPOINT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900">
        <property type="entry name" value="MITOTIC AND DNA DAMAGE CHECKPOINT PROTEIN HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04005">
        <property type="entry name" value="Hus1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011312">
        <property type="entry name" value="Cell_cycle_HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR011312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS17440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="368" mass="40962" checksum="84D43F71D0A15ADC" modified="2011-10-19" version="1">MRFRTDLRNVRTFSKLTAALSSLEKIAWVRLDDDTVRFTVIPDTGSQVWASLSVPLIFDNYHIQSAEPNNTINLELPLQPLLRALKSAIGSSYANLRLTKKDGLPMLSMTIHTMTRDSGGEARGRKAPGFGANSGEAEEDHFTSQSFAPEPLELTMKREREKIITQDIPVRVLHPDTVETIMQPKVREPDVHIQLPPLLQLKAISDRFTKLALTTSTNSRYSTPKLVLQANMHGSLRLSLHTDTLSITSTWTGLENPELDESQLPVPIEEHPSTIFKRAGPDRWATVRVDGRDWSRVLSVGRLEGRVIACFCDEHALILYVYVPHLDGGDQGREERGVGGEREDVVTVIKGHDLDGVMVTDGATRTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0SH23</accession>
    <name>G0SH23_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyltransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0068410</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697130.1">
        <property type="nucleotide sequence ID" value="XM_006697067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SH23"/>
    <dbReference type="STRING" id="759272.G0SH23"/>
    <dbReference type="GeneID" id="18260879"/>
    <dbReference type="KEGG" id="cthr:CTHT_0068410"/>
    <dbReference type="eggNOG" id="KOG2898">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048121_0_0_1"/>
    <dbReference type="OMA" id="WFRFLWD"/>
    <dbReference type="OrthoDB" id="272512at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063:SF60">
        <property type="entry name" value="LYSOPHOSPHATIDIC ACID:OLEOYL-COA ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063">
        <property type="entry name" value="PHOSPHOLIPID ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="268"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS17512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="335" mass="37349" checksum="D422103741300392" modified="2011-10-19" version="1">MEKFSQFRDRGSGVSPFLPVTTLSSQLARLGHAICFCIRLPLLLFYAGVYFLFLQYIPLPVVIRKLLLWIFLAIPAVWWVDVQLDGVRRGLLSQQPRTRVPHPGSVIAASFSSPLDALYLAAVFNPIFVASHPRSRKVRRISLLKAVCYALSADFQLADSIESQPGGSRGLTDLRALLSRYPNRIIVVFPESGTTNGRGVLPLSPCLLTTPAENAIFPISLRYTPPDVTTPVPGFRAWIRFLWNLLGRPTHCVRVRIAEPIYNTSRATNGGDWVNVPPPRAQQQQQQEGDGGPGNREEQALLDNVAEALARLGRAHRVNLTLRDKKAFVNVWVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>G0SH29</accession>
    <name>G0SH29_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative maltose fermentation regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0068480</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697136.1">
        <property type="nucleotide sequence ID" value="XM_006697073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SH29"/>
    <dbReference type="STRING" id="759272.G0SH29"/>
    <dbReference type="GeneID" id="18260886"/>
    <dbReference type="KEGG" id="cthr:CTHT_0068480"/>
    <dbReference type="eggNOG" id="ENOG502S86Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016574_2_1_1"/>
    <dbReference type="OMA" id="KAWYYLR"/>
    <dbReference type="OrthoDB" id="4132249at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="514"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="523"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="543"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="599"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS17518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="720" mass="79622" checksum="7FB66EAFB38A3BB7" modified="2011-10-19" version="1">MSTAVKRACDACHRRKVKCDGINPCRNCSASQLTCTYNSIPQKKGPKGSRAKVINELKETQRQSTLTAKLQNGALASQTLAPTPRLLTKELLKTCVDFFFNHMYPIMPILERSRLDQDVMYMDQNLDTYCLLTSLCSFVSLQPGMVMPMTDPFNPDMMFGNNIVTGTLLMEETLRVRKGFDYVASPTLNSVCTSYFLFAVHHALEMHEKAWYHLREATTLVHMMSMNEEQAYLQCDNGDGIDVSRRRRLYWLLFVTERAYALRYRRPLSLQASIALPAPSDHPADPFAHSGTSFLRLIGLFRGFDEVLLQLWMKTKSECSDPYLMALEKQIQDVLPPYLNDTNAQLSEIQINQQWLKHKAWEVSIANGNDNNAGLSYVDNINMHELLPMVSHFPGNLGLQGLSLFEHLLNVTCALTEILAMQPAPRTPFIPSPHDQLRKILNVVHVIRNGEHRFLPLLLNKVHAELPKLASPMLQNAPESAACPATIDIFDGFGTAGMAQPPCGFSSEFDNKFGVPRLNDMTPNSHSGSNSNSPNSAPSGNNDMNSPFTTSSPGGIMSPGIDLPHGLQTDFTSMPEMVMSPMSHAPPPSSLPTSGAMADQQSQQPQHTPISPFSNSNHQIHNIAGSNVNPPTNMGLASQMHLGQGMNSGINTGLAQTVSSTSLLARVQPQQHRTHSFAMGMSQLRAVGDFQALQRANTDVMNPLTLNTMGTTIDFNALQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHA8</accession>
    <name>G0SHA8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0069350</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697215.1">
        <property type="nucleotide sequence ID" value="XM_006697152.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0SHA8"/>
    <dbReference type="GeneID" id="18260973"/>
    <dbReference type="KEGG" id="cthr:CTHT_0069350"/>
    <dbReference type="eggNOG" id="KOG0955">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002663_0_0_1"/>
    <dbReference type="OMA" id="NTSKWSH"/>
    <dbReference type="OrthoDB" id="20839at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15670">
        <property type="entry name" value="ePHD_BRPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000007">
        <property type="entry name" value="Bromodomain containing 1, isoform CRA_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF107">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="514"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="181"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="424"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="695"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="905"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1022"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1214"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="267"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1026"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1045"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1116"/>
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        </location>
    </feature>
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        <location>
            <begin position="1126"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1160"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1228"/>
            <end position="1260"/>
        </location>
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        <location>
            <begin position="1280"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1317"/>
            <end position="1329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS17597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1329" mass="146225" checksum="80639AB616182508" modified="2011-10-19" version="1">MAPSPATPRRTARGRPRGRPRTSGSASASRSRRAAADAPTTEPPPKRRRYIPGGPGGGGRFVEEDGTEIPTESHGASTSTGTASASARPRASQRTSSPTAAYPRRERSTRLRNANAASAVNRDQQDDMQYSSAAAVAAAVVQNEGYKPREERGWEEFHPNLDIDGIFMVYAAAEVDGLVKPGQQQPQAASQTGPDAPAVNGTALPTKQDNTGSAAPAAEDAANGTPGRQPQEGKLTLGAGPVPPETPSRRRVGRPPRDSVSLYANRPPEPAPAPKIPKPLPIYGQTSKERLDLKMPSYRRTNRVALFESKSFGQARYVDKSMSNVGYQESDHFIRPERRLIKASDANLDEEIEQWGVSKLDGEAAVQNPAGNVGRVEYDMDEQDDMWLEKLNAQRKANDLDPITREIFEIAITKIEKEWHALEKRIPKPNPKPPQTHRPRSSSAAAVNGEPHVGEEQDSKCAICDDGDCENTNAIVSVMAAIWPSIRSATVFRLFRRANGSVASASLLDAAFRYVTCIFCPNTDGAFKRTNSSKWAHLLCAMWIPEVSLGNHTFMEPVMEVEKVPKTRWKLTCYICNQRMGACIQCSNKNCYQAFHVTCARRCRLYLKMKNSQGALAVLDGTLPLKAYCDKHCPEDYAQENKVAEATREAKKFYKKTMKGRIWADSRASALQLAQTHHHYYHQNVVPEHHASDEALKNGVSGGDKKKDKPPKNMWKLPSGAPIIPQAVFDVVESALARFPIRKRKDFVGECCRYWTLKREARRGAALLKRLQLQMETFTSMELTRRNFAAMGPTGKTRLSRRIDFCRTLIADLEQLRGITEEVVEREADKYEAVEMEQDFVDTCYFPVARELQPVLDKAFSLDKNVFKKAFLEMQDRLDERFYTTTLLFTHDFCQAICTGINTDPAPSAQEVRPDPIDASPNKSNNYAEARDRRRLAKRIVRAVQPMLESALRAEADICNKPYDELRAQLEAMLEASLDIKQAQQAASITVSNPASVAADQEDVDMADAPADGQIIVVDQSTGHDEDAEGEPDGDAEGDLDEPMPDVKEQSVEVSADEIKVDTSAHLSRQGTPPQPNEHNQQQQAKALINGFSEAAKHHNPPGNLSPNSFPGGPYTTATLQLDSSITINNPTTTAPPESDPLTPPQSTSSFSHPVPAPTASGSTLPIITTTAPDPPSGYSLPANVQDDSFLTKGGVPWYLSGFEPHGTTALAEETWTTGREAWGGNKKMGKKKKKKKKKEKEKEKKKKKEKEKEKKKKKXXXXXXXGGGGGGRRRGIRKGGWLLRVEGGAEGLEVAGSTGSNTKRKNRKGSAGNGRVLRRGVRSSNRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHM5</accession>
    <name>G0SHM5_CHATD</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0070560</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697332.1">
        <property type="nucleotide sequence ID" value="XM_006697269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHM5"/>
    <dbReference type="STRING" id="759272.G0SHM5"/>
    <dbReference type="GeneID" id="18261094"/>
    <dbReference type="KEGG" id="cthr:CTHT_0070560"/>
    <dbReference type="HOGENOM" id="CLU_1825077_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="141" mass="15480" checksum="8BDCE39F89D1D6EF" modified="2011-10-19" version="1">MIPPPEPTSEFKPSSKGGSSALRSGRSSRSSTIARKAEKFISPRGPAPIPIYDFDSAPAPHIGHEKPKDVQPSTTNNTKESKPGFFRGMFGSANDETPMAVAYHSWISRVMMRKFNQESLEVGDLEIELIPIQHNMKLTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHQ6</accession>
    <name>G0SHQ6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0073010</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS16976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697558.1">
        <property type="nucleotide sequence ID" value="XM_006697495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHQ6"/>
    <dbReference type="STRING" id="759272.G0SHQ6"/>
    <dbReference type="GeneID" id="18261339"/>
    <dbReference type="KEGG" id="cthr:CTHT_0073010"/>
    <dbReference type="eggNOG" id="ENOG502R8BV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021363_0_0_1"/>
    <dbReference type="OMA" id="GYACSFY"/>
    <dbReference type="OrthoDB" id="5244801at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="690"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="409"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="601"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS16976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="756" mass="81557" checksum="E622CC9EBA39CDC6" modified="2011-10-19" version="1">MPIDSTTMAASLEKLEKQLDRLEKLFSKRKKSKPSHDLGRAVPEAASSTWFQQEDDDDLVHFPQPPFIRPTSSRMVARDELLMAPRLTRRARSLPESPSTPRLTTPTKPGSSSTRLADSPQSTRPDPKTPKKGLLPKLRPDIPRRSSSLFLAAATFDIPPELFELNFSSPTGRTEYSLSSGRSPAKSASPVSVSPKSQVERKRRSSHNTLEQPKAHEALQEMLKNEKETLGDAVQSQRESQIIVPADGSDEAAPLSPRLVPLPMPGPEEIEFFGLEQTQTSTIQNQHSTKGTDPTTPSKPDSNPAQSLHEPTLGEFLALKDEDIADSQPVATTHTKPLMPPPLRISSNPQSPVVSTPSSPVCEFELLTLCPPLASRPAAAAALEAARIATKYEFDLVYVVNLWPTNITRSGRRNNSNSSNSPTSSPLSGPSSGDDTTNPTNTTPQNTASSMTGRLLAAYGLPSIMCPFRISAPVHQKVLRTKGWLEYRSEGASLDEFARGYSCSFYTGYTPTTNPPTTTTKSEVRGGQQQQGGKKERRIPNRGVVFAAFRLPYEDGTVRCSDARELDELHRDAERLVDMVLDGQLTKRQVAMKKSRQAAMQQGQNQSQEQGGKGVMNSKQKRSSPGGPSKPITPTKSMTSLKGNLNPYSVSTTHFPFPLPPHTTTAPATTMQYGYHHPAAQLSAPALALPSSSSSISGSTNTSSMYSAISTSTSSTTPLTAQTSATSPSPSSIRCVAGGNVGRGGVRSEQAAVLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHQ7</accession>
    <name>G0SHQ7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
            <ecNumber evidence="7">4.2.1.93</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ATP-dependent NAD(P)HX dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0073020</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6S)-NADHX + ATP = ADP + phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19017"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(6S)-NADPHX + ATP = ADP + phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32231"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.93" evidence="7"/>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS16977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697559.1">
        <property type="nucleotide sequence ID" value="XM_006697496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHQ7"/>
    <dbReference type="STRING" id="759272.G0SHQ7"/>
    <dbReference type="GeneID" id="18261340"/>
    <dbReference type="KEGG" id="cthr:CTHT_0073020"/>
    <dbReference type="eggNOG" id="KOG3974">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030651_0_0_1"/>
    <dbReference type="OMA" id="IMNSIPH"/>
    <dbReference type="OrthoDB" id="8110916at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047453">
        <property type="term" value="F:ATP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110051">
        <property type="term" value="P:metabolite repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592:SF0">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="1 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF C-terminal" evidence="8">
        <location>
            <begin position="8"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="178"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="217"/>
            <end position="221"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS16977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="287" mass="30578" checksum="62430F0FE5AC48BE" modified="2011-10-19" version="1">MSATTKDILSRVRMMIPPLLSKFHKGQLGRVAVIGGSEDYTGAPYFSAMASAKLGCDMSHVICTPTAAQVIKSYSPNLMVHPYMRSSPSPSSPSLTTDASTEPHSLASRIIAMLSRLHVLVIGPGLGRDPLMHDTCALVITAARERGMPIVLDADALLIVQNKPELVRGYKLAVLTPNVVEFDRVTKALGIEDDGTSETGRVEKLARALGGVTVLQKGKKDFLSDGEKTMVVDWEGGRKRSGGQGDTLTGLQASDLTDEVHNAFMNIFGEVDVDGDEGDETGGAARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHU6</accession>
    <name>G0SHU6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sorting nexin-4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Autophagy-related protein 24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CTHT_0073420</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697598.1">
        <property type="nucleotide sequence ID" value="XM_006697535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHU6"/>
    <dbReference type="STRING" id="759272.G0SHU6"/>
    <dbReference type="GeneID" id="18261380"/>
    <dbReference type="KEGG" id="cthr:CTHT_0073420"/>
    <dbReference type="eggNOG" id="KOG2273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027221_2_0_1"/>
    <dbReference type="OMA" id="RGMDQER"/>
    <dbReference type="OrthoDB" id="205639at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06863">
        <property type="entry name" value="PX_Atg24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000035">
        <property type="entry name" value="Sorting nexin-4 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000042">
        <property type="entry name" value="Vacuolar targeting protein Atg24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949:SF2">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="16">
        <location>
            <begin position="61"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="403"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGS17016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="487" mass="54753" checksum="E47CFC9D0583CA84" modified="2011-10-19" version="1">MAVLDQDNFSNISWHSDQNDIAGPSTSRSSPQDNNNSRGSPGYAGSSSRRDAALSRVGGDILECTVTEPHKENDGTKDAYVSYLITTHTTFSTFQRPTTQVRRRFTDFVFLYKVLTREYQGCAVPPLPDKQRMEYVRGDRFGPDFTARRAYSLQRFLTRLALHPILRRASILHQFLESPDWNAIMRTRSQRGGLGGAGVGGDGQSQGGSVFDSFADSLMNAFTKVHKPDRRFIEVKEKADKLDEDLNLVEKVVARVARREADLETDLRELAEQFQKLITLEPGVESAVRAFAASVEDTAAGLKKLRDHTDQDYVGSLRDMVAYSGALKNLLKAREQKQLDYEQLTEYLNKSTAERDAMQSGSIGGGMISSFSAAALGGASGFLRSKVEDFRGVDHEQARRDRQRKLELRIDELTREVENARKEADAFAEQVVKEVESFEWIKRVEFKRQFAGLVDAHIGFYDGVIETWERFVREMEKEGAVKSADTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0SI05</accession>
    <name>G0SI05_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0074030</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697657.1">
        <property type="nucleotide sequence ID" value="XM_006697594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SI05"/>
    <dbReference type="STRING" id="759272.G0SI05"/>
    <dbReference type="GeneID" id="18261441"/>
    <dbReference type="KEGG" id="cthr:CTHT_0074030"/>
    <dbReference type="eggNOG" id="ENOG502QQN3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_4_3_1"/>
    <dbReference type="OMA" id="GTYMMDS"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054416">
        <property type="entry name" value="GST_UstS-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22041">
        <property type="entry name" value="GST_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="25"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Glutathione S-transferase UstS-like C-terminal" evidence="2">
        <location>
            <begin position="104"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="234" mass="26766" checksum="27DAD85C1DDEA01F" modified="2011-10-19" version="1">MSTPDKPEPIVLFDLPSKEPCSTWSFNPWKTRLLLNYKGLDYRTDVPNPPDPHSETPYTIPTIRLPNNNYIMDSRRIANALEALYPEPPLHLDSPVLASLETIIPRIIQALAPLFMPRVAYRLLPERSSAYFVETRSKWYGDLLELEKEKGGDVAWRATEEDLKEITRMLKEKPEGPFFLGKVSYADFVWGSVLIFVKRCGEDALEGLLKTTGDESVHLALLEGLKPWTERNDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0RXX6</accession>
    <name>G0RXX6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0004640</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691004.1">
        <property type="nucleotide sequence ID" value="XM_006690941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RXX6"/>
    <dbReference type="STRING" id="759272.G0RXX6"/>
    <dbReference type="GeneID" id="18254502"/>
    <dbReference type="KEGG" id="cthr:CTHT_0004640"/>
    <dbReference type="eggNOG" id="ENOG502S16F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_525916_0_0_1"/>
    <dbReference type="OMA" id="TCECTDE"/>
    <dbReference type="OrthoDB" id="3923593at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409117" evidence="2">
        <location>
            <begin position="19"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="548"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="624" mass="63099" checksum="255AC605FBE9F9ED" modified="2011-10-19" version="1">MKTTSLLTFGLFAGLSTAYSHPRQMMRWRRGFFNNPASSNVLLGTGVAATTSTATEDIVTDTAVATDILSSTSTESTAVPLETGVSTSSSETTSSSSSSSSSSSIDSILLSTGIATEVPLSTGVETTTSVLLSTGVSSATESVITNAPFFPITNATTTAAAGTGTGTIGAGITTLTVSTTEIRTITSCKEEVIACPTRTEDLATLPTEALSTVIVTDTVILTEVVCPVTAVPSISSSVIEDASKGLITPSTTITGPTTTTATETPSETATESVSQTSTAVPIAITSSAVASTGITTLTVSTTEVRTVTSCRSEVIDCPTRTEDFASFPTEALETVIVTDTVILTEVVCPVTEVSSISSSIIEEASKGNITPSVTLTGPAEVSATSTAVPIATSVDQDTTITRTLTSTGTRTVTVKKPTATVTPGTGSGSGSGNGNGNGNGNGSGSDTCVCDPTTVTITQAAATVTVTQAAVTVTEASTVYVTLTNHINIPSTTITSAVVTTTAVPGAGEGEGEVDDECPTDIEEVVTVTSTATADIATETAVPEEETVTVTQTDAPSAEVTESPSAETTETPAVTEATETATATETATETATETSTETATATPIVFPGKHKKFRNKFRPFHDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0RXX8</accession>
    <name>G0RXX8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0004660</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691006.1">
        <property type="nucleotide sequence ID" value="XM_006690943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RXX8"/>
    <dbReference type="STRING" id="759272.G0RXX8"/>
    <dbReference type="GeneID" id="18254504"/>
    <dbReference type="KEGG" id="cthr:CTHT_0004660"/>
    <dbReference type="eggNOG" id="KOG0308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002197_0_0_1"/>
    <dbReference type="OMA" id="PMWLGDV"/>
    <dbReference type="OrthoDB" id="2421129at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051246">
        <property type="entry name" value="WDR48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021772">
        <property type="entry name" value="WDR48/Bun107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862:SF14">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11816">
        <property type="entry name" value="DUF3337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="20"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="83"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="216"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="562"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="789"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="920"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="595"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="667"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="693"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="802"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS23764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="948" mass="103600" checksum="9D885FF7543BCDDC" modified="2011-10-19" version="1">MAKKARQRISYVLEHPNSSPGGHRLGVNGLAIDRENAILYSGGRDGVICAWDLKRSLQNTHAAVTDPSSHPNPKSIASFRTQTHAHTHWINDITLVQHHNALVSASSDLQVKLWRPLASDAQEPVPIGHHRDYAKCVATPNQSTNWVASGGLDRRIYLWDLSGKGQVLEIDVSGEEVVEKGSVYALGVTHSVLANGGPESIVRLWDPKSGKRITKFVGHTDMIRAILVSEEGDMVLSASADQTVKVWSVTAGRCMHTLTMHDHSVWALFSDDPGLNVFYSSDRSGLVVKTDVRDTMGDLDKGLCLAVAKEHEGVSKIVAWDGSIWTATARASINRWQDVDLTGELRLPEAYKQHRASMMSVRSKESTGPTAGAEGARTTIPAKSVLRISNTASFPLVIDRNADDPFQGQARKTDPSEVEVEPIYHSPVETIEGQFGLVKHKLLNDRRRVLTLDTAGDVLMWDLIQCRPIRSFGKRHLEDVEPEVNTKEAVAPWCSIDISSGNLTVVLEPYNCFDAEMYADELTLDEPIEFREDQRINLGKWVLRYLFANLIDEEIRRDEEFRQSLTKSPPTKKSRGGREAPPLSIDIPPLPKFDPTTQRANNNGSHPPVTPGLVIGLATPGSPMIQMGEGTFSPLEKMPSHLAGRPSVEQEDYFSDTIGTPEPPLTTRLTQGQIPGQEPPSTEESSAKNSTEVAKEKEKDKDKENGTKGSTTFNMKKFRMNMSFGTKKLSRSTSTAAAEKPALGTTAAAGGVDDKADESETSSTHEKEFDDSFLGVIQRLRSEYEKLISDHPDKPLDSKITPAPPNDTPPLNIPPGTKVIIQEETTGGSAEVYRGTVASVGADADIIEEKAPLWLGEALLLNVLPAKEPVKVSFVLYPWKDSLPPIASADGNNRLNANRMLRVKKILAYVAERIDPAYENEGDVEGEQQGGEGGGKEAEAGGLVGVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYT4</accession>
    <name>G0RYT4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Lysoplasmalogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0007820</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM86 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS24070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691312.1">
        <property type="nucleotide sequence ID" value="XM_006691249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYT4"/>
    <dbReference type="STRING" id="759272.G0RYT4"/>
    <dbReference type="GeneID" id="18254820"/>
    <dbReference type="KEGG" id="cthr:CTHT_0007820"/>
    <dbReference type="eggNOG" id="ENOG502S96P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079086_2_0_1"/>
    <dbReference type="OMA" id="RAAWFHR"/>
    <dbReference type="OrthoDB" id="2133758at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012506">
        <property type="entry name" value="TMEM86B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31885">
        <property type="entry name" value="GH04784P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31885:SF6">
        <property type="entry name" value="GH04784P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07947">
        <property type="entry name" value="YhhN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS24070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="24095" checksum="702F7F09E6539BBA" modified="2011-10-19" version="1">MSQSLSLSSAVLAASVGAAVLYATLVRSRPSVWRMTIKTCSTALLAAVVMVEGGPLRLAGALALGSLGDAFLAWDDETSFFRGLASFLAAHLLYIAVFTHGKTEVHIFWALLTSSGWRAAAAGSLALLVPTMVALLLPRLGQALRAPVVVYSLTIFVMAFSALTLDSPHVVAGALMFTASDSILAADRFLVAPTSPHKPWMQHAVWVLYYAGQFLIAMGFLALQTSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYX3</accession>
    <name>G0RYX3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0000900</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690643.1">
        <property type="nucleotide sequence ID" value="XM_006690580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYX3"/>
    <dbReference type="GeneID" id="18254128"/>
    <dbReference type="KEGG" id="cthr:CTHT_0000900"/>
    <dbReference type="eggNOG" id="ENOG502SJUN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007003_1_0_1"/>
    <dbReference type="OMA" id="HEYPTFP"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053187">
        <property type="entry name" value="Notoamide_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="236"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="586"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="731"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="595"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="613"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS23401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="777" mass="88201" checksum="8B918962B3CEF0AD" modified="2011-10-19" version="1">MLYQLQEVRVKAPQRLRSAPFCRVPSLFTGEVPECDGKRPACSPCDGASVKCTYLSENPEETRTSATKRKYDEVASRLSQYEELWTLLQTRNDQDIQEIVRLIREKKDAEWIVRYVRGGDLIKQTRVSPETRFRYAFPDFANWPTLFHDPDDPYLKAQIFDISLPRTRPTLPDPRGFASAESTPTLRGATIRKVYPEFVYEVPYHAAAVHDPRISCVKASMWTSVTSDDDLVRKLLGIYFQFEYPRNRFFAKEPFLDDLANGEMRFCSPLLVNAILANAAHGLQDDTQRVAYWTPQSLSYLFLAEAKSLWDTECQREPSLPTIQAAMVLSLRYGADGNDKLGDPLLQQAVAIAEHMELFTRYDSKDPVLSKVRAFTAWSLFSWQAVACYHNMKAPYVSEPPSFASPDLNTISGLTGDIYLRYPGQGAMIQSYLGSSVKAETELHCIMQDINVECRRAGVLGNSPPALQSAVGFYTRLDKWFQELPEELQPHNIVMPHQLHLHMQYYTVLIQLFESWTSNPAAIFNGRTAQDIALIARARLETLIRIYYLRHSFTHLDSILVLYLLLLGSISLRLIAPRRSSSPYPSNLLALTDAPSSSTSPGSSRHSSPSTTVTQDQSKRSPNSQTEGLSSENSPPPPTTTFLLCAQGLRDQGQNNYLGMMMFNILYNLAKKIKPNLCKDLDNIKLSYTYDPVEKRAQDKAKLGDVVKDIEMQWPVFRWVDDKCKGMGTVLKELEKLSIDEQEEGEQQQKQKEVKDLNEAELEEELGVLPVRQVVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZ24</accession>
    <name>G0RZ24_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0001450</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690694.1">
        <property type="nucleotide sequence ID" value="XM_006690631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZ24"/>
    <dbReference type="STRING" id="759272.G0RZ24"/>
    <dbReference type="GeneID" id="18254183"/>
    <dbReference type="KEGG" id="cthr:CTHT_0001450"/>
    <dbReference type="HOGENOM" id="CLU_567401_0_0_1"/>
    <dbReference type="OrthoDB" id="4763081at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="481" mass="55272" checksum="F5632D22DE66417D" modified="2011-10-19" version="1">MRPIHYEIYERPQSSSDNSSSEDDIPTTLAPHALPEAILVHINCFNLYRLCSHALRKSKLVPDKTEADSLDRLWTEEGEYERDVKRIDPREILCWERKMGMEQRMDVEKQRGRWPWMRITVDLIGIRRIERLGERPRYHGEDTEENGLQYGYAMVNVDELKGVIAEVKHKRLRLRLPRGLPSQPPTGFYIWNTECPPLISECRIYGGWKSDPDCNGLRRWFGPYDPYNSRMLKATRLDHPSIRGITFFLDRVDARPLGMHVHWKNHCEQCIYLYDQSNDNGPGDAEMAIFPGKTSVEWYPLYFYVPIGKDDKIVGFGILRTKEPILHGTELATKMVPHALMVRLEHAGDIIASQNHLVNKPMETFDWCLAQSRGSGPVALVYGVPHYGCLIWEWFGGYDGTNPEKHCRFEPKFELPPSLKHRGLNFSDCDDAIYTWAPLDGLESATEYHDGLPKYGYGSSGILLRYNDGSQRTVGLGISAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZ30</accession>
    <name>G0RZ30_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="2" type="ORF">CTHT_0001510</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EGS23458.1"/>
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    </dbReference>
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    <dbReference type="STRING" id="759272.G0RZ30"/>
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    <dbReference type="OrthoDB" id="5153231at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
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    </dbReference>
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        <location>
            <begin position="711"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="727"/>
            <end position="740"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="752" mass="85130" checksum="0ED13AA6A170F305" modified="2011-10-19" version="1">MPERTTQILIAEQGRVCPLCTLMLQDGDKVWACTGNNTRSWEREFVLKLVKGDPREAVKEIPSDQKAVPLPSADIAYHRACHRLIRENMGTAWYLEAILKHDFCNDWVIWYHTKQRPAILKAAIVPALEAEFRPAQGKLPYEIWFRIAGYLMSEFIVAQVLNVTDRTIGTTVEFDVTRDVYATFVKVLGNVYIKRIRNLKSNEKPEAREYRILAAQSAHPARIMYVGRDHLGIRKVQFAVPGRTLPGPNSVPGVWWQRWNLSGKLRNMMICRAFNKKIGPRPNDKIARSEMLFPVRDTQPLTFVSEMDLAAIPLRMQRLRPFSLEDWRPDSLRNVIAVCDPEVKGHTFMHRVGLNEPGTIGYSVAVTKYGIQKILVHREEYTFPEYRYWIRDEPEWCCWVYMPMNVGEHITQICASPSHMLNKDKSTGLTFITNRNRARYFSRWATPDPTWADAGILRDNNNETYLYDCLYKPNATGDSMYYGVGRQPKDRSIVVHLAFKGSDLRLEKCNYRYPLTPTTIPLDDQNAWFFSCCSLKDVVKITLCVSRESADEEQRLRREKGFWLLPPSSNDRSSPQAAAAPPPGAVLGMLLEYANGDKESVGSFRFDWATSVPPMEVVDAPGQALYIGYTRDQAAWVRQVRLGPPSEDERFLLRWKKVPWDGMLEWWVSGVGMELKLLGFSDNGVPTNGGRRTAEAADDGSELAVAESAVTEAGGQLAVPGGRRVGHSQSSGADKGQQSGVAGHPASWDTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZ73</accession>
    <name>G0RZ73_CHATD</name>
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        <submittedName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0001940</name>
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    <organism evidence="3">
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006690680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZ73"/>
    <dbReference type="STRING" id="759272.G0RZ73"/>
    <dbReference type="GeneID" id="18254232"/>
    <dbReference type="KEGG" id="cthr:CTHT_0001940"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_590505_0_0_1"/>
    <dbReference type="OMA" id="GFYTHAP"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="71"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="400"/>
        </location>
    </feature>
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            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
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            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="463" mass="50309" checksum="3C3A89CDF5569183" modified="2011-10-19" version="1">MRAATNGSLIPPAWQGIDGYTPGSVPTGAPIMGVPRGKNFSSAHHNVVDQTAITDFASFCRKTTMVKHVRRSHQRGVLSNEMEDSLSETGSEHSPATPKSHNALPWQPYPLPLDQPSQPLQRAASFADFGQPMPYALPPQYSQRHSMSSGGVADYHAGGPHPQQTLPHLPHPNQHLLQRAPSLPHHSFFVPEQSNPAVATMHPNPHHAPQMPYQQVPRQAVERPHLEIPYPNILTAGLQSSPSTFSPGSGRSPSVQEGFYTHAPPPSSAGYTLHSAGPDQLSPLSFPGSQVPHSSQAQAATPRTHSNPMEMQRDDHVMQQNHQHAGQQHLKGQPKVQSPGPFQSQTSAQGRPNQQPQPVQGPNPDVPALPEAEPTHHQQHPQQAQQQQQQQSDVTAPQTPADDQQWFAYQAGATPVSIPPHHQIGGIHSYAPTLMGMYPDPWAEKFELDTGGIPLPSARIAEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZB5</accession>
    <name>G0RZB5_CHATD</name>
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        <recommendedName>
            <fullName evidence="2 5">Vacuolar protein sorting-associated protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0002370</name>
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    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2018" name="Nature" volume="561" first="561" last="564">
            <title>Structure of the membrane-assembled retromer coat determined by cryo-electron tomography.</title>
            <authorList>
                <person name="Kovtun O."/>
                <person name="Leneva N."/>
                <person name="Bykov Y.S."/>
                <person name="Ariotti N."/>
                <person name="Teasdale R.D."/>
                <person name="Schaffer M."/>
                <person name="Engel B.D."/>
                <person name="Owen D.J."/>
                <person name="Briggs J.A.G."/>
                <person name="Collins B.M."/>
            </authorList>
            <dbReference type="PubMed" id="30224749"/>
            <dbReference type="DOI" id="10.1038/s41586-018-0526-z"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.52 ANGSTROMS)</scope>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="eabf8598" last="eabf8598">
            <title>Architecture and mechanism of metazoan retromer:SNX3 tubular coat assembly.</title>
            <authorList>
                <person name="Leneva N."/>
                <person name="Kovtun O."/>
                <person name="Morado D.R."/>
                <person name="Briggs J.A.G."/>
                <person name="Owen D.J."/>
            </authorList>
            <dbReference type="PubMed" id="33762348"/>
            <dbReference type="DOI" id="10.1126/sciadv.abf8598"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (9.30 ANGSTROMS)</scope>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2021" name="Sci. Adv." volume="7" first="eabg4007" last="eabg4007">
            <title>De novo macrocyclic peptides for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complex.</title>
            <authorList>
                <person name="Chen K.E."/>
                <person name="Guo Q."/>
                <person name="Hill T.A."/>
                <person name="Cui Y."/>
                <person name="Kendall A.K."/>
                <person name="Yang Z."/>
                <person name="Hall R.J."/>
                <person name="Healy M.D."/>
                <person name="Sacharz J."/>
                <person name="Norwood S.J."/>
                <person name="Fonseka S."/>
                <person name="Xie B."/>
                <person name="Reid R.C."/>
                <person name="Leneva N."/>
                <person name="Parton R.G."/>
                <person name="Ghai R."/>
                <person name="Stroud D.A."/>
                <person name="Fairlie D.P."/>
                <person name="Suga H."/>
                <person name="Jackson L.P."/>
                <person name="Teasdale R.D."/>
                <person name="Passioura T."/>
                <person name="Collins B.M."/>
            </authorList>
            <dbReference type="PubMed" id="34851660"/>
            <dbReference type="DOI" id="10.1126/sciadv.abg4007"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the VPS29 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690785.1">
        <property type="nucleotide sequence ID" value="XM_006690722.1"/>
    </dbReference>
    <dbReference type="PDB" id="5W8M">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.52 A"/>
        <property type="chains" value="A/B/C/D/E/F=1-201"/>
    </dbReference>
    <dbReference type="PDB" id="6H7W">
        <property type="method" value="EM"/>
        <property type="resolution" value="11.40 A"/>
        <property type="chains" value="S/T=2-194"/>
    </dbReference>
    <dbReference type="PDB" id="6XS8">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.95 A"/>
        <property type="chains" value="A=1-201"/>
    </dbReference>
    <dbReference type="PDB" id="7BLP">
        <property type="method" value="EM"/>
        <property type="resolution" value="9.50 A"/>
        <property type="chains" value="B/D=1-201"/>
    </dbReference>
    <dbReference type="PDB" id="7BLR">
        <property type="method" value="EM"/>
        <property type="resolution" value="9.30 A"/>
        <property type="chains" value="B/D=1-201"/>
    </dbReference>
    <dbReference type="PDBsum" id="5W8M"/>
    <dbReference type="PDBsum" id="6H7W"/>
    <dbReference type="AlphaFoldDB" id="G0RZB5"/>
    <dbReference type="EMDB" id="EMD-0154"/>
    <dbReference type="EMDB" id="EMD-12223"/>
    <dbReference type="EMDB" id="EMD-12226"/>
    <dbReference type="SMR" id="G0RZB5"/>
    <dbReference type="IntAct" id="G0RZB5">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0RZB5"/>
    <dbReference type="GeneID" id="18254275"/>
    <dbReference type="KEGG" id="cthr:CTHT_0002370"/>
    <dbReference type="eggNOG" id="KOG3325">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063749_0_1_1"/>
    <dbReference type="OMA" id="VRGNMDY"/>
    <dbReference type="OrthoDB" id="10258130at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07394">
        <property type="entry name" value="MPP_Vps29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000024">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028661">
        <property type="entry name" value="Vps29"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN VPS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9 10 11" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="6">
        <location>
            <begin position="4"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS23543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="5W8M"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="6H7W"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="6XS8"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="7BLP"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="7BLR"/>
        </source>
    </evidence>
    <sequence length="201" mass="22223" checksum="DB594BF34AF1F96A" modified="2011-10-19" version="1">MAFLILVIGNLHIPDRALDIPPKFKKLLSPGKISQTLCLGNLTDRATYDYLRSISPDLKIVRGRMDVEATSLPLMQVVTHGSLRIGFLEGFTLVSEEPDVLLAEANKLDVDVLCWAGGSHRFECFEYMDKFFVNPGSATGAFTTDWLAEGEEVVPSFCLMDVQGISLTLYVYQLRKDENGTENVAVEKVTYTKPVEPTGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZK1</accession>
    <name>G0RZK1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Borealin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0003240</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the borealin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690871.1">
        <property type="nucleotide sequence ID" value="XM_006690808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZK1"/>
    <dbReference type="GeneID" id="18254362"/>
    <dbReference type="KEGG" id="cthr:CTHT_0003240"/>
    <dbReference type="eggNOG" id="ENOG502S9QE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038589_1_0_1"/>
    <dbReference type="OMA" id="ITMQQKQ"/>
    <dbReference type="OrthoDB" id="2392550at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018851">
        <property type="entry name" value="Borealin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018867">
        <property type="entry name" value="Cell_div_borealin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16040">
        <property type="entry name" value="AUSTRALIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16040:SF7">
        <property type="entry name" value="AUSTRALIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10444">
        <property type="entry name" value="Nbl1_Borealin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Borealin N-terminal" evidence="11">
        <location>
            <begin position="59"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="148"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="185"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="282"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="341"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="382"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS23629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="425" mass="44705" checksum="428AE68D1EF49641" modified="2011-10-19" version="1">MAVLGVTKRKSDQISTTSDEEQQLALSAMSTQLAPRNGEGSQRYRSPIKKRRIGITAAQKQALIENLQLEITERARRLRSNYNLHAQSLRTRIEMRVNRIPMALRKLTMGELMERYEHQKLSASTGGIMKSLKDSTTSRPVLSRSMTAAVPSVAPAKRKSDEISKDKENELVEQADPSSKRHRGNTVSGISRPATSHALSLTTSNKTLTRSVIGSPTKATASRPAMTPGRPTLAQSVIEKSSKAPRPTPLSPRKTANPSVPPSSSTAGSTSVKRQRGATVTAAVASSNPPSSAQRPISRAAAAPSRTAQRRVSGTSESSENSTSTVIRRRPISAPPGSQPKLISTNAAASIAPATSSQKESTAGKTRTAVVAAVKRGNAGVTTTPSTTPATTTAAKKPAGAKLVGTSSSNPGGSSAAGRVLRKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZY9</accession>
    <name>G0RZY9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ser/thr protein phosphatase family-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0008110</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691341.1">
        <property type="nucleotide sequence ID" value="XM_006691278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZY9"/>
    <dbReference type="STRING" id="759272.G0RZY9"/>
    <dbReference type="GeneID" id="18254849"/>
    <dbReference type="KEGG" id="cthr:CTHT_0008110"/>
    <dbReference type="eggNOG" id="KOG4419">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019028_0_0_1"/>
    <dbReference type="OMA" id="PISFYRV"/>
    <dbReference type="OrthoDB" id="7722975at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07407">
        <property type="entry name" value="MPP_YHR202W_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000043">
        <property type="entry name" value="Ser/Thr protein phosphatase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.780.10:FF:000008">
        <property type="entry name" value="Ser/Thr protein phosphatase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.780.10:FF:000009">
        <property type="entry name" value="Ser/Thr protein phosphatase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053828">
        <property type="entry name" value="Nucleosidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014485">
        <property type="entry name" value="Pesterase_C1039"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041823">
        <property type="entry name" value="YHR202W_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF43">
        <property type="entry name" value="SER_THR PROTEIN PHOSPHATASE FAMILY (AFU_ORTHOLOGUE AFUA_3G04160)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21953">
        <property type="entry name" value="NadN_nucleosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017316">
        <property type="entry name" value="Pesterase_C1039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408685" evidence="1">
        <location>
            <begin position="25"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="Putative 5'-nucleotidase C-terminal" evidence="2">
        <location>
            <begin position="375"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="622" mass="70829" checksum="24C8811408865D82" modified="2011-10-19" version="1">MRPTKDILGALTGTVTVLTSFVAASQPGAEQPVPGPMRDLIWGKLNFLHTTDTHGWHAGHLLEGQYSADWGDYISFAQHMRKKADDHGVDLLLVDTGDRVEGNGLYDASKPPGKYYYDIYREQHIDIICSGNHELYKADTADREHEYSVPNFRDVYIASNLDYIDPKTGERKPMARRYRKFRTKNQKLDIVAFGFLFDFTGNANNTITIPVQQTIEEIWFQQAIREETDLFVVIGHVGVQMDEFKEIHRAIRQHNPDKPILFFGGHAHVRDATQYDSRSFALASGRYFETIGWMSIDGELKRKEKHGDLKRREETSSLSFHRRYIDNNLLGLYHHSGLNSTTFHTEHGRNVSAMITKARKELNLDYAFGCAPKSLWMSRAPYPSEDSIYSWLETEVFPDVVVNASRKDIPRLVIANTGVIRFDIFEGPFTIDSTYIVSPFTSKFVFIPDVAYSSAHKVLKLLNSAGRIFAESGPMDNRFMANPEQFAIRESIIYDNIVDSNGHQKPMDTHGKTVLTPGYTTRDDVGTDGDDTIHAPINFYVVPNCFQAKIGISKDEEPKNVDLVFLDFIKPWVLAALDFLGTPYQDEDVLPYVEERFTDMMAGWIEKNWPKRCDENGVCGCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0S018</accession>
    <name>G0S018_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0008420</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691370.1">
        <property type="nucleotide sequence ID" value="XM_006691307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S018"/>
    <dbReference type="STRING" id="759272.G0S018"/>
    <dbReference type="GeneID" id="18254880"/>
    <dbReference type="KEGG" id="cthr:CTHT_0008420"/>
    <dbReference type="eggNOG" id="KOG2071">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015606_0_0_1"/>
    <dbReference type="OMA" id="ARSDFAN"/>
    <dbReference type="OrthoDB" id="343582at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16982">
        <property type="entry name" value="CID_Pcf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000016">
        <property type="entry name" value="mRNA cleavage factor complex component Pcf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045154">
        <property type="entry name" value="PCF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054127">
        <property type="entry name" value="Pcf11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047415">
        <property type="entry name" value="Pcf11_CID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021605">
        <property type="entry name" value="Pcf11_Clp1-ID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921:SF3">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX 2 PROTEIN PCF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21936">
        <property type="entry name" value="Pcf11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11526">
        <property type="entry name" value="Pfc11_Clp1_ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="4"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="746"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="501"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="781" mass="82907" checksum="242F6279D43B9433" modified="2011-10-19" version="1">MADNSAEVAEDYRQALEDLTMNSRIEIATLTNIARENANHGLAIAEVLINHIKKAPPSRTLPALYVLDSIVKNVPTPYALYFGPKLYSIFMGAYTKVDNATRRKMDEMLKTWKEPVPGSLSTKPVFPIEQVRPIENALIAARNAAMAANQNSYQGQQQLLRGRQPVPSRDTPTPPTGRPYPPPPQGQAPYPGPNGHQQLGAVPSNAQQPYPGHPPVSGPNPIPPRATTQPAPPVGGYAGYQPPAGRDVYGAQPAAISIDKLKDDIQQLIVAEKAEFAQDPLDTSKQTRLKALLDLQAIIQSQDMPQEQLMIIRDRVAELAVNKLRPQPQPACPPVTAAAGPAVAVGAAAPVGAAHALLSPYTGTSPTATTSPNPVVPQQPTPIPPAAVAVVAAALARQPSVPTATVPPSHPSVPPTTSGGTGSSGGGISLDSLFGKGALATLLRMNATTPQQTTVPQQTSPPAPPLPPPPVAAPATTGIPPSAVATIAAALQAAPTPPPAAQQSQPSSQQHPADPSRPGAPVLPQDPAALLAILRQSGLLKPAATATPPVDTGIQLTPASLKIYRPHLIPQLLENLGPPCTQCGRRFKTDEEGRRRKTAHMDWHFRVHQRSAEAERRGQHRSWYVDELDWIRSREAIDTEYITPAPGQDDLTSATTTLPYHIAPFPPTGSSSTKTSTSFGPGSKVPYLPVPEDAASRAANSTCPICQEKFEMKWLDEAQEWVWTDAIRAGPQGRVYHASCHREAAGAVSSTTTSGNNGKGVLGKRKAEDEGKKRIKTEPFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G0S054</accession>
    <name>G0S054_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Oligopeptide transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0008790</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691406.1">
        <property type="nucleotide sequence ID" value="XM_006691343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S054"/>
    <dbReference type="STRING" id="759272.G0S054"/>
    <dbReference type="GeneID" id="18254917"/>
    <dbReference type="KEGG" id="cthr:CTHT_0008790"/>
    <dbReference type="eggNOG" id="ENOG502QQ2H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010539_2_0_1"/>
    <dbReference type="OMA" id="TPTAYVW"/>
    <dbReference type="OrthoDB" id="627262at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045035">
        <property type="entry name" value="YSL-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645:SF0">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="546"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="636"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="695"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="725"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="763"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="35"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="494"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS23215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="792" mass="85765" checksum="72D4D2C53B192167" modified="2011-10-19" version="1">MLDAITIHTSPQRPSMQPAITCTFRFSYWEFEVHERDKKKQRRESRQQQLSSSRPQQVQQPTASWSKPNPAQPQLSAPKPIPAPAPAPEAPPVPSLPLAQPRLSTESIEPIERSPNSNHVPKYSHVPGQSFTWRAVFVGLAVGLVICFSNTYFGLQTGWVSIMSMPASLMGFGIFQLLFRHSPLPFSPVENVLVQTVAGSMAIMPLGCGFVGVLPAMRYLLREDEMGPVVLSPGKLVLWGLGLCYFGVVFAVPLRKQVIIREKLKFPSGFSTAVLISVLHGKTGDPDTRDGKSASSVVAADFASLAAPPRSDENDDESTIDEDVSPLHAESWRRNVQLLLLCFFVSGLFTFATYFFPLLRNIPIFGSVAASTWLWTLNPSLAYVGQGIIMGPATTLHMLLGATVGWAVLSPLAKGRGWAPGRVDDWENGSKGWIVWTSLAIMLADSVVSLAYLAVRSVAKALPSDIREAAPQRIKKLLGWRSHAGYTSLNADAQDSDAYESEAGTEADDAPPDQQISDRTVVVGLILSILFCIACIHIVFGDLVPLYATVTAVLMALVLSIMGVRALGETDLNPVSGISKLAQLFFALIVPQSNKSSVLINLVAGAVSEAGALQAGDMMQDLKTGHLLGAAPNAQFWGQVIGATVGAIVSAFIYVLYTSVYEVPGDLFQVPTSYVWIFTARLVTGKGLPPMAREWAIGAGILFTITTILRIRTVNKPWRVLIPSGIAVAVGMYNVPSFTLARAIGGLFGWWWRRVAGWQETPLIVLASGFILGEGFLSIVNLLMQSAHVPHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0L5</accession>
    <name>G0S0L5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chitin-binding type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0010440</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691567.1">
        <property type="nucleotide sequence ID" value="XM_006691504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0L5"/>
    <dbReference type="GeneID" id="18255082"/>
    <dbReference type="KEGG" id="cthr:CTHT_0010440"/>
    <dbReference type="eggNOG" id="ENOG502SPFY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1124406_0_0_1"/>
    <dbReference type="OrthoDB" id="1193027at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-1" evidence="4">
        <location>
            <begin position="98"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="40"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="152"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="156"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS22575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="247" mass="24697" checksum="F07E056B195EA8A8" modified="2011-10-19" version="1">MPLQTTLSLACGKQVPNAVAASVGAQTTCAAPRVCGWPKPTPTPPTTTISTTTTSSTAATTSSSTATTTTSQVISPSSGTVSTSVIPTPTGPLLVTTNGQCGNNTICIGNPNFGPCCSQFFWCGSSIEYCGAGCQSQFGACFGVPGIPAPPASNGTSPTTRSTSQAPPASPSTISTTTITTSSTTTSSTASPTPIVTIPPGMVSTTDGRCGNGVTCLGSTWGRCCTGVRALRPGPLKEIPDETIRDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0S136</accession>
    <name>G0S136_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Elongation factor 1-alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0012210</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691738.1">
        <property type="nucleotide sequence ID" value="XM_006691675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S136"/>
    <dbReference type="STRING" id="759272.G0S136"/>
    <dbReference type="GeneID" id="18255259"/>
    <dbReference type="KEGG" id="cthr:CTHT_0012210"/>
    <dbReference type="eggNOG" id="KOG0052">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007265_3_5_1"/>
    <dbReference type="OMA" id="AIRDMGM"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03693">
        <property type="entry name" value="EF1_alpha_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03705">
        <property type="entry name" value="EF1_alpha_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000005">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000211">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000168">
        <property type="entry name" value="Elongation factor 1-alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_A">
        <property type="entry name" value="EF_Tu_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008969">
        <property type="entry name" value="PRK12317.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="6"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS22746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="460" mass="50161" checksum="9DA0E7A2F86F6CBE" modified="2011-10-19" version="1">MGKEDKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAELGKGSFKYAWVLDKLKAERERGITIDIALWKFETPKYYVTVIDAPGHRDFIKNMITGTSQADCAILIIASGTGEFEAGISKDGQTREHALLAYTLGVKQLIVALNKMDTCNWSEARYNEIVKETSNFIKKVGYNPKTVPFVPISGFHGDNMLEPTNNAPWYKGWEKETKDGVVKGKTLLEAIDAIEPPKRPTDKPLRLPLQDVYKIGGIGTVPVGRIETGVLKPGMVVTFAPSNVTTEVKSVEMHHEQLAEGLPGDNVGFNVKNVSVKDIRRGNVCGDAKNDPPAGAASFESQVIILNHPGQVGAGYAPVLDCHTAHIACKFAELIQKIDRRTGKAVEDNPKFLKSGDAAIVKMVPTKPMCVEAFTEYPPLGRFAVRDMRQTVAVGVIKKVEKQTGGPAKVTKAAQKAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1S1</accession>
    <name>G0S1S1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative cell fusion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0014600</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691973.1">
        <property type="nucleotide sequence ID" value="XM_006691910.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S1S1"/>
    <dbReference type="GeneID" id="18255498"/>
    <dbReference type="KEGG" id="cthr:CTHT_0014600"/>
    <dbReference type="eggNOG" id="KOG0379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002697_1_0_1"/>
    <dbReference type="OMA" id="CIGYIPA"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061245">
        <property type="term" value="P:establishment or maintenance of bipolar cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000049">
        <property type="entry name" value="Cell polarity protein (Tea1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244">
        <property type="entry name" value="KELCH REPEAT DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244:SF456">
        <property type="entry name" value="MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="445"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1141"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1472"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="764"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="815"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="948"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1034"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1163"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="527"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="559"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="571"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="613"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="643"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="671"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1141"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1472"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1499"/>
            <end position="1512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS22981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1512" mass="165871" checksum="1A2FF7DF1754DC47" modified="2011-10-19" version="1">MAFLFRGKKHQDRALQSRDGPQGPGSAMGGAAARVRDEKGSRSTPTGSLHSLDNEGSMGSPDQPYGRQRGQSLDQPQQSQTSPPQMQLQQQYPGEPPYRNGAPPLSNNPNASLYPWSQRRLTYTTSHPSPFPRYGAAVNSVSSKEGDIYLMGGLINSSTVKGDLWLIEGGSPNLACYPLATTAEGPGPRVGHAALLVGNAFIVFGGDTKIEETDILDETLYLLNTSTRQWSRALPPGPRPTGRYGHTLNILGSKIYVFGGQVEGLFMNDLSAFDLNQLQNPNNRWEILISNDPAPPQGKVPQPRTNHTMVTYGDKLYLFGGTNGYQWFNDVWSYDPVTNSWTLLDCIGYIPSPREGHAAALVDDVMYIFGGRTKEGADLGDLAAFRITTRRWYTFQNMGPSPSPRSGHSMTTVGKTIVVLGGEPSSPTASVNDLAIAYCLDTTKIRYPNDSGASGPRTRRPSDVTSPSSRGAAPSRDGSAGASENRRYTGVPSNNPYRSPPGGEFSPPNGHPSGPSKVPRSGGPTGPSGPSPQGQPPRPTQVGAVPRPRTASLERQEQPSRGSPITSPVSQQQQQQQQQQQQQQQQQQQQQQQQQQQSTIPKESDDVAANGRRTPNQNPPRSSSRQADVQTPDAAKQKPPKPSGNQGPSDNATDSAPKQVGRPVSPPPPNRQNSNPLSRRSSTRNSQTVALLKELDAARNRNAWYATELELARKNGYIPNVSLNPALDGRAMDAFDDDDKPLIEALLAMRNELANVQASVDKQAVLAAKQIAEVERQRDAAIQEAAYLKAKLAALRGGSTAGTPQFDEKDAEDRIGELSKKLAFALNSQKELQDQLDRLTIEHEAEKKARKLAEDTVTAAQKRLAELETYKQQASSDLERLKSELHLVQREAREQSVNATEALAKIEMLRIEKEALEQKYSEIVGSSKEQSETFESLRQAVAASAETKALLERRLDEERALREKVEAKLNKLKAEHEARTAELVAVTQRLRDAEELAEQHANEARVHREAVLAGLDKIAARDASKSDKVDSERLASLQSQINAANALVRKYQQEIDNAADKLRGAEERIAGLEAYQEQASREGVSVRRQLQSTLREVQSLQATNAELKQQLAKQQLEANAMLIQYNALKDILLERGISPTAAAARARSSPRGTPREGSPEMRLRELEQQLAEARSALEEAKAQAALQQQESESLYRDKLAQLENDYQSTVHYVKGTEKMLKQLNEQLARYKSENNRLKEQVVELEDKLSTERSAAKLSDAPADWETRQQQLQGEIDRLQAQLRENSQKFEQQITSIQQELAEVQKERDSALGKTEEAVRRLETTRRDLETLQQENARLERRAIDAEQKVTTLLDQVEMSVDNFRRRSGRQATDSGTSGETISAIASANATNGGGPGHTRQESLTDVESLYSKGDAATLASRRNSLGLGASIGDARNSAALDSLANELESLRSHWEQRNYRLSNTFDFDMPTPTAASPATATAGGVAPGNASAGLSESLADWRKNRLEEEQRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1Y1</accession>
    <name>G0S1Y1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CTHT_0015250</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 15">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 15">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS23041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692033.1">
        <property type="nucleotide sequence ID" value="XM_006691970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1Y1"/>
    <dbReference type="STRING" id="759272.G0S1Y1"/>
    <dbReference type="GeneID" id="18255563"/>
    <dbReference type="KEGG" id="cthr:CTHT_0015250"/>
    <dbReference type="eggNOG" id="KOG1376">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015718_1_1_1"/>
    <dbReference type="OMA" id="YMASCIL"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000008">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="16">
        <location>
            <begin position="49"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="17">
        <location>
            <begin position="248"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGS23041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="449" mass="50088" checksum="AE3839A5433AECA0" modified="2011-10-19" version="1">MREIISLNVGQAGCQIANSCWELYCLEHGIQPDGYLTEERKNAEPDTGFSTFFSETGQGKYVPRTIYCDLEPNVVDEVRTGPYRGLFHPEHMITGKEDASNNYARGHYTVGKELIDQVLDKVRRVADNCSGLQGFLVFHSFGGGTGSGFGALLMERLSVDYGKKSKLEFCVYPAPQTATSVVEPYNSILTTHTTLEHADCSFMVDNEAIYDICRRNLGLERPNYENLNRLIAQVVSSITASLRFDGSLNVDLNEFQTNLVPYPRIHFPLVAYAPIISAAKAAHEANTVQEMTMSCFEPNNQMVKCDPRNGKYMATCLLYRGDVVPNDAHAAVAHLKTKRTIQFVDWCPTGFKLGICYQPPHQVPNGDLAKVNRAVCMLSNTTAIAEAWSALSHKFDLMYSKRAFVHWYVGEGMEEGEFAEAREDLAALERDYEEVAADSLEEGEGEAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0S241</accession>
    <name>G0S241_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-tRNA hydrolase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0015900</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS23101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692093.1">
        <property type="nucleotide sequence ID" value="XM_006692030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S241"/>
    <dbReference type="STRING" id="759272.G0S241"/>
    <dbReference type="GeneID" id="18255628"/>
    <dbReference type="KEGG" id="cthr:CTHT_0015900"/>
    <dbReference type="eggNOG" id="ENOG502SF32">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070640_0_0_1"/>
    <dbReference type="OMA" id="TPEEWWV"/>
    <dbReference type="OrthoDB" id="1733656at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409220" description="Peptidyl-tRNA hydrolase-like protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS23101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="33892" checksum="0BEFA2943C0E259C" modified="2011-10-19" version="1">MRLSKAATFLALPLLAAATGADAQTKPVQPQAAAQAVIASQRGAGAFTQYMAKFQSFLSNIVGAQNPLGGADGDSSSSSSSSSAKAAGAGKKKVMAEPKPIATLTLEGWRDALYAPVKENATVAEEWLVLVSGGNKTCYGRCTALDTAFNVSALDLANLPSPSVRHLHLGRLDCDAQPILCNVWSANPGSLWSLSLLPAPAPVEIHTRSFNLSLAAPTPTAQDIVTAYLARADPEVDEKAEIPTRRRWHRFENEGWLHPFDGKLAKLGLSVPVAYFFYGLNAVPTWVLMLVVSFVSRTLINRRLAPSTQPGAPASSRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G0S255</accession>
    <name>G0S255_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative mitochondrial dicarboxylate protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0016040</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS23115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692107.1">
        <property type="nucleotide sequence ID" value="XM_006692044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S255"/>
    <dbReference type="STRING" id="759272.G0S255"/>
    <dbReference type="GeneID" id="18255642"/>
    <dbReference type="KEGG" id="cthr:CTHT_0016040"/>
    <dbReference type="eggNOG" id="KOG0759">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_14_1_1"/>
    <dbReference type="OMA" id="TTRFGAY"/>
    <dbReference type="OrthoDB" id="448427at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000107">
        <property type="entry name" value="Mitochondrial dicarboxylate carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="34"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="135"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="235"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS23115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="329" mass="35687" checksum="B345E623E8F093EE" modified="2011-10-19" version="1">MQAAENNTTASPRPAGATAVLKSEDKSSSQSMRKPIHYPFWFGGSASSMAACVTHPLDLVKVRLQTRTSSMPSSMVGTFVHVVKNEGLRGLYSGISASLLRQITYSTTRFGIYEELKSRFSSTHHTGPDGKPKPPSFPLLIGMATVSGVIGGIAGNPADVLNVRMQHDAALPPARRRNYAHAIDGLVRMVREEGPASLMRGVGPNSVRAAAMTASQLASYDMFKRTMLALTPLHDGLVVHFTSSFMAGVVAATVTSPIDVIKTRVMSAHGNHGVLHVVREVSAKEGLGWMFRGWVPSFLRLGPQTICTFIFLESHRKVYRKLKGIEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0S271</accession>
    <name>G0S271_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0016200</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692123.1">
        <property type="nucleotide sequence ID" value="XM_006692060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S271"/>
    <dbReference type="STRING" id="759272.G0S271"/>
    <dbReference type="GeneID" id="18255658"/>
    <dbReference type="KEGG" id="cthr:CTHT_0016200"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013226_0_0_1"/>
    <dbReference type="OMA" id="LENQMDP"/>
    <dbReference type="OrthoDB" id="10044938at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052600">
        <property type="entry name" value="Nuc_rcpt_coact/corep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23295:SF6">
        <property type="entry name" value="NEOSIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23295">
        <property type="entry name" value="NUCLEAR RECEPTOR COACTIVATOR 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="576"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="641"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="281"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="354"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="385"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="404"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="519"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="641"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="691"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS22104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1028" mass="107914" checksum="E8458A6D04EB60EC" modified="2011-10-19" version="1">MAFFSPEPDRLEYNSRIYTLYPAPFNFPSTSAIASAWMQDEEEQSPRIVAASLSPLSPKPISVQSIQNTVVSKLQDQAATAEAAAAATVASPAPPPLFPNISHHRPVPLPLPLAMDPMPEQPAIAESIVTNADAVSDVGRDDNESINYSDGDERDVGQEPQDKADPDAAADANDDYAKTFDSPIEPSENEHEHEHEHEHQGEADEAQLNQPGVPEAAESMNAFSVPMTLPFAQSTQNIQSTQPSQVQAQAQAQTPAAALQIQVPASAATLQSPSAPPGLPGLPFTASTTAATPAHEQANGPDTSSSSGAENPFSAPKASPPLSPAAPNTVPSTEETLADPSADATPVAPPAPVAAPATAAAPAPQSANEDDAAVDIQKLVNDLTAKAAGSSSASSNAGPSQDKPSAAAAVTTAPTTAATLQATPTSSTSSSTSTLPAPSHPSLPPKPNLPPPPASLPAIPPSAFQPRGTNGPVPSVPMNSASAGAPHGTYMPPGAPGAGNDGIASLPPHPSAAYGAPSHLPPSHMPSAPHYPPASDASAPGNYHHGASIKQLWEQFLADEKRYTSEAKWERFPEGSRIFIGNLSSERVTKREVFDVFHRFGRLAQISLKNAYGFVQYHTVAEGQAAMLGAQGIELGGRRIHLEVSRTQKKKEDRDRSPNRRRGREDDRFNGGDRGWRRDDYRPGRSPSPRRGRDGYGRDRDFGGHGERRRSRSPRYGRYGDEYRRRSPSPHRRVPSDADRLDLPRRFGADVPDVQFLLLQEVSREFVNWVQGAFHNRGLKTDVMYLNPRFPRDTVVQRQVVEGVHAIVDLDYAAQSKGKIPIQVFIRSGGSTVRFELYQDIDPPVAAELVIREKNNSAAHLAQPQAPTAAPYAPHAYAPPAAAPPAYAYPYAAPAAAPVAPAQPAAPAAPDLTNIVGQLDNNALQALLSSLQTAQAAQNPAAAAHSGVPAAQPTAPAAPAAAPQIDVNALLGNLRAAAAAQQPAAPAPAAPPAYGYGAAAPAPAVPTVDASTAQHVQSIIDTLKRAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2J3</accession>
    <name>G0S2J3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Casein kinase substrate phosphoprotein PP28 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0017430</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692245.1">
        <property type="nucleotide sequence ID" value="XM_006692182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2J3"/>
    <dbReference type="GeneID" id="18255781"/>
    <dbReference type="KEGG" id="cthr:CTHT_0017430"/>
    <dbReference type="HOGENOM" id="CLU_1204646_0_0_1"/>
    <dbReference type="OrthoDB" id="21120at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019380">
        <property type="entry name" value="Casein_kinase_sb_PP28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10252">
        <property type="entry name" value="PP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Casein kinase substrate phosphoprotein PP28" evidence="3">
        <location>
            <begin position="167"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="179"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS22226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="230" mass="24902" checksum="364C72BDA944FABF" modified="2011-10-19" version="1">MAPNKFKKFTRRTDRFDDVILDEDGNEISMWSEEAQRQLANGLQSGEDSAPSGSEADPQSPTSLPPSGGALPPPTEAQGPPMGRNERKALKKARKEAALRKAAERSVQVGDLPPSDSESEVEAPQPGPATGSSQTRGQASLLSADEELDRQFSRMAVGTGKAKKDPRAEIKSEQMKADLERLRVIRERREAEAARKQAEKEAKAASIKAKSAEIEAKLAKAKSKKTGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2W3</accession>
    <name>G0S2W3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0018710</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692365.1">
        <property type="nucleotide sequence ID" value="XM_006692302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2W3"/>
    <dbReference type="GeneID" id="18255909"/>
    <dbReference type="KEGG" id="cthr:CTHT_0018710"/>
    <dbReference type="eggNOG" id="ENOG502SUAH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_499647_0_0_1"/>
    <dbReference type="OMA" id="CENIAWE"/>
    <dbReference type="OrthoDB" id="4768051at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="545" mass="60756" checksum="8DF635A800078A6E" modified="2011-10-19" version="1">MVVLYLHADKPSLDLWERRIFITLTILFSSLVSLSVGSLLVVLGAALRWPLLASRGHTPREVNLILSMANPSGSLRLLGYYSGGWDRGRLRFRKWKATTWVVLLYLVVNIIGRLSIAIFGLSYGMNESVVYPAMVNDFGNKGFMQESYMLRDLAQAARFSITGVVNVPTPFNRSDPSTYNMNDIGGLGLKRSVNSETGAVTYTYPLREYRGPEEYPSSDRIMHNGNSTLPQDSPTFMYILDALDGDAASQYATGPDSLTTHYTWAMDWDESKIGDPAACATTLVNWRGNGTISFFYECTTCLTSNSGIPGLDTSILSNFNSSRLPYAAGILPRISPFDYFYDYSGPSGEFVARVYSSSSERIHQPQLFELPDTPYYFYLEPKFHTKPVPLNFEIEIAHLVARLPILAIIGAERELPRKTRDPNATSADAYIVTNLEVKWPRAFGILAGLVAGQVLVIGVAAVATRNVPIRDHDSLLSVARLLRTAMEKIEGRSMASGEELAECIERELRLGEGMRYGTEIVDEGTRRVDLWEGMGENFERDKKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3H6</accession>
    <name>G0S3H6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0021070</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2017" name="Protein Sci." volume="26" first="327" last="342">
            <title>Interaction network of the ribosome assembly machinery from a eukaryotic thermophile.</title>
            <authorList>
                <person name="Bassler J."/>
                <person name="Ahmed Y.L."/>
                <person name="Kallas M."/>
                <person name="Kornprobst M."/>
                <person name="Calvino F.R."/>
                <person name="Gnadig M."/>
                <person name="Thoms M."/>
                <person name="Stier G."/>
                <person name="Ismail S."/>
                <person name="Kharde S."/>
                <person name="Castillo N."/>
                <person name="Griesel S."/>
                <person name="Bastuck S."/>
                <person name="Bradatsch B."/>
                <person name="Thomson E."/>
                <person name="Flemming D."/>
                <person name="Sinning I."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="27863450"/>
            <dbReference type="DOI" id="10.1002/pro.3085"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) OF 76-293</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692578.1">
        <property type="nucleotide sequence ID" value="XM_006692515.1"/>
    </dbReference>
    <dbReference type="PDB" id="5M43">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.65 A"/>
        <property type="chains" value="A=76-293"/>
    </dbReference>
    <dbReference type="PDBsum" id="5M43"/>
    <dbReference type="AlphaFoldDB" id="G0S3H6"/>
    <dbReference type="SMR" id="G0S3H6"/>
    <dbReference type="STRING" id="759272.G0S3H6"/>
    <dbReference type="GeneID" id="18256145"/>
    <dbReference type="KEGG" id="cthr:CTHT_0021070"/>
    <dbReference type="eggNOG" id="KOG1716">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023312_0_0_1"/>
    <dbReference type="OMA" id="FAWQGMQ"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14518">
        <property type="entry name" value="DSP_fungal_YVH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848:SF4">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="10" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="79"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="147"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="421"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS22559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="5M43"/>
        </source>
    </evidence>
    <sequence length="443" mass="48900" checksum="0F283FDCE12A038E" modified="2011-10-19" version="1">MGSIDQSTNAHVDSIVMRSGPEDDEVSPSADPRLGVGVLAVNHLAGSSGVPVDENIPKGPSRQQILKAIGFLRSSMALNRIKGDDELFVGGVFGANRARLIKEHRITHILSVIDHTVDRENEAFRHVKHLSIDIDDMEDQDILIHLPKIVRFIDSGLRGIDPSDSSAVASPGVVLVHCAMGKSRSVTAIIAYLLWKYPYRFGKSDPNISAKEAVSRALEWVRETRPIAGPNDGFMRQLEMWWDMGCPADSDDAVEREPAYQRWLYQREVEDAARIGRAPDRLRFEDEAATAEGDKNGKINDTNGGAELRCKKCRRVLATTPFIVPHKDRGNADRSDCPHYFIEALSWMRPILEEGKLDGRLACPNTKCGATIGRYAWQGFRCTCGDWVGPAFSLQKSKVDKVVTGSRQNSGRMAGISIRIPPRPVPSQSVVPENGGDKCKQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3Q8</accession>
    <name>G0S3Q8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone deacetylase complex subunit SAP30 Sin3 binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0030280</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAP30 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693480.1">
        <property type="nucleotide sequence ID" value="XM_006693417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3Q8"/>
    <dbReference type="STRING" id="759272.G0S3Q8"/>
    <dbReference type="GeneID" id="18257066"/>
    <dbReference type="KEGG" id="cthr:CTHT_0030280"/>
    <dbReference type="eggNOG" id="ENOG502RZ9X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090091_0_0_1"/>
    <dbReference type="OMA" id="HEYRYAY"/>
    <dbReference type="OrthoDB" id="510958at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024145">
        <property type="entry name" value="His_deAcase_SAP30/SAP30L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038291">
        <property type="entry name" value="SAP30_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025718">
        <property type="entry name" value="SAP30_Sin3-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13286:SF23">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT SAP30 SIN3 BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13286">
        <property type="entry name" value="SAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13867">
        <property type="entry name" value="SAP30_Sin3_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase complex subunit SAP30 Sin3 binding" evidence="8">
        <location>
            <begin position="149"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS21184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="200" mass="21703" checksum="859437D09A9AFC3F" modified="2011-10-19" version="1">MPPKAARSGHDDSKADSTAAKEKNVGGAGSNGKMRRVASSQGASLREVASANAANAAAAAAAAAAAAAASAAATASASTNANGNQENNVPGLQWPAFERDVLHAYRRAYRLKTPTSFVSDVHQWVLTQPGSIGLYSPTIARRKEFRRQTSDQLNAAVRKHFNAMGLQENDVIVEFLHKVRKEHMKVRRRRFLYMPRDRDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3Z1</accession>
    <name>G0S3Z1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CTHT_0021940</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692663.1">
        <property type="nucleotide sequence ID" value="XM_006692600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3Z1"/>
    <dbReference type="SMR" id="G0S3Z1"/>
    <dbReference type="STRING" id="759272.G0S3Z1"/>
    <dbReference type="GeneID" id="18256232"/>
    <dbReference type="KEGG" id="cthr:CTHT_0021940"/>
    <dbReference type="eggNOG" id="ENOG502RY3D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031730_1_3_1"/>
    <dbReference type="OMA" id="VQWNGWP"/>
    <dbReference type="OrthoDB" id="4849160at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF36">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409294" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="16">
        <location>
            <begin position="27"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="17">
        <location>
            <begin position="27"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGS20367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="339" mass="37281" checksum="010BFAE5BF942D5F" modified="2011-10-19" version="1">MPPSTSSLLSILLTLSSTLIPDPVFAHSHLSHIVVNGALYHGYDPRSPVKNPDSNKTYNNPRPNHPGSVAWSYAAFDDGFVAPENYSHPDIICHIGATSPKAHAPVRPGDLIHIQWNGWPVGHVGPILTYIAPCKSQSGCAGVDKTTLRWTKIDESRPVLEILPNNENRWDVEHGRAGIVGKRWATDVMVAANNSWQVEVPRGLARGAYVMRHEIIALHFAAKRGGAQNYPVCFNLWIEGEKEGSVTLDGYDAREFYRDDHIGVWVNVTAPALASYIIPGPTIASWAMPVPYAQQTSMLLRSEGTPVVVTRSTETVLWTAEVTPTPTGQAVRHRYHLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0S418</accession>
    <name>G0S418_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative FMN binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0022230</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the flavoredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692690.1">
        <property type="nucleotide sequence ID" value="XM_006692627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S418"/>
    <dbReference type="GeneID" id="18256261"/>
    <dbReference type="KEGG" id="cthr:CTHT_0022230"/>
    <dbReference type="eggNOG" id="ENOG502S020">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059021_3_0_1"/>
    <dbReference type="OMA" id="GNLIICE"/>
    <dbReference type="OrthoDB" id="10250990at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798:SF5">
        <property type="entry name" value="FLAVIN REDUCTASE LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798">
        <property type="entry name" value="FLAVOPROTEIN OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="6">
        <location>
            <begin position="104"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS20394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="317" mass="35085" checksum="65E623346FA80CAD" modified="2011-10-19" version="1">MAAERTANWEKQLQRNPHPDFKKVEASRPPYNSSDFRYTKTPDPNWKFGDGANHLYCTSSTNSTSESNNTNGHKCVPPSEIKHIPINPYAPNRPSTLNYKLLISAVVPRPIAFLSTRSADGKTTNLAPFSYFSVIGHDPPLFTIGFACPIESTKAKDSLRNLVETKECVINIISEHWIEAANSAAVNAPYGVSEWDVAGVTPVYDCETVKVARVKEAVFAIEGRLESVREFQSRSVPGKVTSTLAIVEGTRFWVREDAVNEEKSLVDFNVLRPIARLGGITYGRVSEGFELPRADFEKDVGGYEGVAKLPSKHPRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4H5</accession>
    <name>G0S4H5_CHATD</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0022850</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692749.1">
        <property type="nucleotide sequence ID" value="XM_006692686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4H5"/>
    <dbReference type="STRING" id="759272.G0S4H5"/>
    <dbReference type="GeneID" id="18256323"/>
    <dbReference type="KEGG" id="cthr:CTHT_0022850"/>
    <dbReference type="HOGENOM" id="CLU_806537_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="344" mass="37681" checksum="0A14B85BEAF066B2" modified="2011-10-19" version="1">MAPGAGLTSDLGNVSVQTVRRKKKKQLEGDAKKLRDEAEKQLDRLKEWEEPFNRPEGVTIPWLKGTGTGTKTETETGTGTGTVEQKLKEAEEQAERLRKWEGQYNRPEEVKMPWMKGVEIEPTMLPMKEEKEEKAPEKAEEAQTQPRLHPSLLEAAAAAPAPPPKPRGRTPSGRRLPSLEEMVPEYDKGEYTLSPRSTSISKDSAIAWEGGGRSSIGQESSSTATAAGTEPRYSWKGTEGMMVAETQPRTEMGETIEAPPRMEKPKRVRSSGLAADGGDFDAAKEGAGREADRLLEQKVQQQKAQEGAGPSKHGHHLHLAEEGKKLHGLKEKIKAKLHIGGTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2023-02-22" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4T2</accession>
    <name>G0S4T2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0023430</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692807.1">
        <property type="nucleotide sequence ID" value="XM_006692744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4T2"/>
    <dbReference type="GeneID" id="18256381"/>
    <dbReference type="KEGG" id="cthr:CTHT_0023430"/>
    <dbReference type="HOGENOM" id="CLU_2249833_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS20511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="104" mass="11621" checksum="A9E1B15008C863AE" modified="2011-10-19" version="1">MIAQKNQNLAYPTEAILKRPPAANTMLANSVNVMLVLAEFATAKPGRKNVYLYDWVPIVSMNLAANALCGYIIKRTTGGEHIKIKNVTATYTTRAWIQRGDRQR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-06-24" modified="2025-04-09" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4X2</accession>
    <accession>G3EQ72</accession>
    <name>NUP49_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleoporin NUP49</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Nuclear pore protein NUP49</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">NUP49</name>
        <name type="ORF">CTHT_0031980</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). NUP49 plays an important role in several nuclear transport pathways including poly(A)+ RNA, tRNA, and pre-ribosome transport.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 6">Component of the nuclear pore complex (NPC). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Nucleoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="1">Symmetric distribution.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited. FG repeat types and their physico-chemical environment change across the NPC from the nucleoplasmic to the cytoplasmic side: GLFG repeats are especially abundant in NUPs in the central region (lacking a charged environment but are enriched in Ser, Thr, Gln, and Asn).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nucleoporin GLFG family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JF276282">
        <property type="protein sequence ID" value="AEN86175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693639.1">
        <property type="nucleotide sequence ID" value="XM_006693576.1"/>
    </dbReference>
    <dbReference type="PDB" id="5CWS">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.77 A"/>
        <property type="chains" value="D/J=246-470"/>
    </dbReference>
    <dbReference type="PDBsum" id="5CWS"/>
    <dbReference type="AlphaFoldDB" id="G0S4X2"/>
    <dbReference type="SMR" id="G0S4X2"/>
    <dbReference type="DIP" id="DIP-61841N"/>
    <dbReference type="IntAct" id="G0S4X2">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S4X2"/>
    <dbReference type="TCDB" id="1.I.1.1.2">
        <property type="family name" value="the nuclear pore complex (npc) family"/>
    </dbReference>
    <dbReference type="ABCD" id="G0S4X2">
        <property type="antibodies" value="1 sequenced antibody"/>
    </dbReference>
    <dbReference type="GeneID" id="18257236"/>
    <dbReference type="KEGG" id="cthr:CTHT_0031980"/>
    <dbReference type="eggNOG" id="KOG0845">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027081_1_0_1"/>
    <dbReference type="OMA" id="KLPTHYH"/>
    <dbReference type="OrthoDB" id="2538017at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024882">
        <property type="entry name" value="NUP58/p45/49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437">
        <property type="entry name" value="NUCLEOPORIN P58/P45 NUCLEOPORIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437:SF2">
        <property type="entry name" value="NUCLEOPORIN P58_P45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21121">
        <property type="entry name" value="Nup49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0509">mRNA transport</keyword>
    <keyword id="KW-0906">Nuclear pore complex</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000433176" description="Nucleoporin NUP49">
        <location>
            <begin position="1"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="repeat" description="GLFG 1">
        <location>
            <begin position="17"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="repeat" description="GLFG 2">
        <location>
            <begin position="45"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="repeat" description="GLFG 3">
        <location>
            <begin position="63"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="repeat" description="GLFG 4">
        <location>
            <begin position="79"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="repeat" description="GLFG 5">
        <location>
            <begin position="96"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="GLFG 6">
        <location>
            <begin position="111"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="GLFG 7">
        <location>
            <begin position="127"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="repeat" description="GLFG 8">
        <location>
            <begin position="142"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="repeat" description="GLFG 9">
        <location>
            <begin position="156"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="GLFG 10">
        <location>
            <begin position="168"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="GLFG 11">
        <location>
            <begin position="181"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="GLFG 12">
        <location>
            <begin position="193"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="196"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="239"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="375"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="32"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="207"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q02199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="21784248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <evidence type="ECO:0000305" key="6">
        <source>
            <dbReference type="PubMed" id="21784248"/>
        </source>
    </evidence>
    <sequence length="470" mass="48589" checksum="5904EB28F07DBA16" modified="2011-10-19" version="1">MSLFGTNTTSQTPAGGGLFGTTTSQSAQTGSLFGTATSQPQQTGGLFGSTATQTPSSQLQSTGLFGSTTATSQPQQTGGLFGSTTTTTSQPQQTGGLFGATATSQPQSTGGLFGNTTTTSQPAQTVGLFGTTTQPQPAQSGGLFGSATQQKPATGGLFGSTTTNTGAGLFGNTSNTIGGGGLFGQTAKPATGGLFGQSTTQPQQQQNATPGLTMGQSTNTQQQVVPGVRIDLSNIKSTTRFNDLTEALQQEIAKIDEEIQKCIRDKEAVDAFLPAHGEQLAAIPTDVNFVTRKSEGAHNALSSDILAIDQLRELVKQDADNARLSFKAIDNLKLPMQYHQAGLWSKQMGGAGTAGASGASADADGQSNADLISYFSKTADEMEEMMKKFEKTITEIEAHLTGVEAHAMAMQNVAAQSRNAAQGGVDERVYELAAVLREFEESILKVAGVVGGVKEGVTELQLRDFMGHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4Y2</accession>
    <name>G0S4Y2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Oxidoreductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0032080</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693649.1">
        <property type="nucleotide sequence ID" value="XM_006693586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4Y2"/>
    <dbReference type="STRING" id="759272.G0S4Y2"/>
    <dbReference type="GeneID" id="18257246"/>
    <dbReference type="KEGG" id="cthr:CTHT_0032080"/>
    <dbReference type="eggNOG" id="KOG0069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_340090_0_0_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12163">
        <property type="entry name" value="2-Hacid_dh_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="9">
        <location>
            <begin position="596"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="9">
        <location>
            <begin position="706"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS21353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="835" mass="93562" checksum="524CBD32F6627FA2" modified="2011-10-19" version="1">MKANKMERGPMHLVESLDKEMGKSIHTCIVPIGDYQLIVTRDPENVQAILASNSADWDVGEHRTASWSPLVGHGVFTTRGEEWKVSRLLVRPQFSKDAINDLDLVERHVQELFEAIDEYMDGRPAVEAGWTNKFDLQPLFYNMTLDITTELIYGYSVHSQNPKARVKLPDLPGYPAPDRMNISSHMDAGKAWIETRGALWKYRWLLPSGEFKKHCEAVHRFADWFVQLRLMRGDAYLDGLADTGAPRKDRYVLLHELAKETQDPDELRGQTLNILLAGRDTTAALLGWIFYFLARHPRVFKKLREEILEQFGPYSPTKPSGLTDFGKLRGLYLNAVINESLRVAPVIPLNERVALRDTKLPRGGHPNPLQPIMVPKGTQVLISTYAMTRREDIWGPNVDEFRPERWIEKGGRKFGFEFIPFGGGVRQCLGQQIARIQTAYIVVRMLQRYDVIENHGRPADAPLKFHHTIENRCGSGVVTLKGHKLLLVTPWPVPAGFAEGLKSEFPDLEVVIHLQNWDGKALPLEVLPPEIWKNVTILLTFSTLPKPEEASTLQYVQLMSAGVNHLLDNPTFKDTNVKFCSANGVHGPQISEWIIGTYLAFEHHLPQYLQQQKEGYWDRAQMHTIQDAANKTIGILGYGSIGRQTARVARAMGMTVHAYTLHPRPTPESRRDHSWTPAGLGDPEGTIPAKWFSGGSPADVHAFLASGLDLLVIATPLTAQTKHLLSKAEFEVLAKTAKGRTFVSNVARGPVIDTNALIEALEGGLIKGAALDVTDPEPLPDGHRLWGTKNVIITPHVSGASVKYFDRVLEILKGNLKRLADGKELVNLVDKKRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5D7</accession>
    <name>G0S5D7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7582 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0024440</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692906.1">
        <property type="nucleotide sequence ID" value="XM_006692843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5D7"/>
    <dbReference type="STRING" id="759272.G0S5D7"/>
    <dbReference type="GeneID" id="18256482"/>
    <dbReference type="KEGG" id="cthr:CTHT_0024440"/>
    <dbReference type="eggNOG" id="ENOG502S6GP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025449_1_0_1"/>
    <dbReference type="OMA" id="DIEAWYR"/>
    <dbReference type="OrthoDB" id="5350192at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056004">
        <property type="entry name" value="DUF7582"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24483">
        <property type="entry name" value="DUF7582"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7582" evidence="2">
        <location>
            <begin position="242"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="652"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="746"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS20610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="797" mass="88605" checksum="EE0AE00DF2D4ABAF" modified="2011-10-19" version="1">MPAIINSPPTQKQLPRLPKSRFAISPPLEAGPSPTHRLPSNVIDALEYASRRLAKKATHHITLLAITREYELPEAMVFRPKPYPSPPPTQTKQNGEFGISSGRPFFSSIPGKNNKSKSKLDALKQLVRGSGLSGSSDGGDIRERIVHVHRDAQYRRNNPGVSGAVRGGNISPAWSEASANSSVADSTLSSPRTLGMKWPGSPVSSMTSPTTPGSVPLTPATPWSVVSDAESKVGTEERKKPFGIRLTYAHPLEQSEEKALAKVLEKAGRRFKVDPLWLPTPIPPSHLSLPVDLVLASTAQNDRLFTSDRLTLLTLDHVYTFRAALLSYSRSSSFHQQASPDPSPSFVPRIPAMTPSASPEGQKALEDAVDELRKLFLANGRKPLKKATLMAAYRWIGPPDCVMEEVFKEFSRVYRRVYAAIEERLGIFDDEESDQDVLSLRNEVAVPVVMKREQKKLTNMSESPRLTPMVEEVRQEQQRQDLLGLEEPERTAKDTDTLDFEDIEAWYRAVQDIVIEYPAPQNKQPLSPLAGSPTKKERLFSPRPAPLNLSHSNILPTPSPTSTSEPKPEPLRPKVNDEEIPPSPTSPPPAPTTATLPPFPWREMVEEAEKERQKENEKQQQRKKDENLVQSKVKGMGLKLQTKFEKPIKKFGVKQQVVEQDQVRKAKDVEEEGEEEEEEEEDGDLTARPLPTQQGTRYDPWSNYATPTAEGMRPRGRGVPSIDGMLLENQGLNWSMEHYRLATGQYPITPADDEDDGVERVGPKTPNGDDDISPITRGEWGFLIGGVKRRLANVGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5L7</accession>
    <name>G0S5L7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0024720</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692932.1">
        <property type="nucleotide sequence ID" value="XM_006692869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5L7"/>
    <dbReference type="GeneID" id="18256510"/>
    <dbReference type="KEGG" id="cthr:CTHT_0024720"/>
    <dbReference type="eggNOG" id="ENOG502RKNZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_688873_0_0_1"/>
    <dbReference type="OrthoDB" id="4581301at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="400" mass="46048" checksum="8B88FF9EB0CA1C35" modified="2011-10-19" version="1">MLSRRVLAIQQLPIRPPSTSTRRPFFQQAGYSTRPDAKSSSQSSGTHSQPPKTSHLQNVPSKPDKEANPSPLFRRIHKLIGQVLPYWVPRAPRKLQYAGKPMGPAAWRRLNNRTRRRWAKKTNRARRRLRAKIEEMRANPPFQVSKLLLDLDSINCPGVRPYTEEDERMLTEQWRSTPSMDALYQRMCALKKEIEQAKFRWNAPLFPHDTRRVTERDVLAVALLGVPAPVKTAGDETAALQEPPLGYFDSQAAWSIGLPPRITEDIHHTTHMLLHRLRIQPKLEAEKMDTPNGLRRSLDRVFRVEDKLETIQRLVAPLLQQPWGRQLVHGYKDVIVGLCAGGLEKESRQQAWRAYWFLQNISAALEADGLGLELEGYAQIRRVRERLTREELALEMGDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5U8</accession>
    <name>G0S5U8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0033680</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693806.1">
        <property type="nucleotide sequence ID" value="XM_006693743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5U8"/>
    <dbReference type="GeneID" id="18257406"/>
    <dbReference type="KEGG" id="cthr:CTHT_0033680"/>
    <dbReference type="eggNOG" id="ENOG502T5A4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_574903_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="475" mass="50731" checksum="087522A2E0F8B2B7" modified="2011-10-19" version="1">MLELSTFNSYNPSCTIDPFLSHVVGWVNNDPAEQYASCTSLYGFPVVSTETPEVNVVFETITTTVSDTTIVVELTTTETTVAETSTSYETLLQTLTVYTATVTSTAPHSYVTTVPWNGGAVVKRGETVPEQRLKRKRRRGCLRPTPTASSPFTASAGSSPSLINLTSSSISVSHAGTAPYWTNSTSSTYPTGTLSHWTNSAASSIPTYATQNVPYWTNSTSSTYPTGTFSHWATSATSSIPTYVTQESPYWTNSTFLTHPAGTSTQWSPSASNSLSTSIARNTLYWINSTSTTSSPPIGTVAYWTASASFSDSTRSSSYSTEYSSSYPTEFSFSSDVPKTFTESFPLSNAFESSSKVPATTVALTDSPEYYSACSCINAVESTSWVTAPTFTSTSTVYETVYTTATATSTSAVTVFVTTTIIQPMTTTLSIDVYADTPTTTTTTVWSTIYSASPTQTAGLTEVAEGQIRSAGLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5Z7</accession>
    <name>G0S5Z7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0025490</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693009.1">
        <property type="nucleotide sequence ID" value="XM_006692946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5Z7"/>
    <dbReference type="STRING" id="759272.G0S5Z7"/>
    <dbReference type="GeneID" id="18256587"/>
    <dbReference type="KEGG" id="cthr:CTHT_0025490"/>
    <dbReference type="eggNOG" id="KOG1716">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012050_0_0_1"/>
    <dbReference type="OMA" id="QAKSRWI"/>
    <dbReference type="OrthoDB" id="426001at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033550">
        <property type="term" value="F:MAP kinase tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008330">
        <property type="term" value="F:protein tyrosine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14521">
        <property type="entry name" value="DSP_fungal_SDP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF519">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE MPK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="319"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="431"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="44"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="356"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="512"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="764"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="886"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="557"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="586"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="604"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="668"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="774"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="791"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS20713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="918" mass="99558" checksum="269BD7A8B8DFDDF8" modified="2011-10-19" version="1">MPSAAARQLYEDQIPSFMSVYDVDGGSIDQSNAVTIIDPSILMDGAKDPKASQLALGPGALPPEPGHRHHDSTSTRTTESADSSPTTTVSCTDSSDLSDPSPSSSPDSPVNLAPLPGPGFASTRSFGGTLSSMANLSVSDSSQERPMTSPGPRRPKNMKGLSIQPPYNPLSSHTLLSEPASPSFIKPVIPAMKRKPSQLSLKTNSSDLLTRTVVEVPNSPIVPPILQRRALKHSTSTPHMLSGLRSATFGPPGGMTIPAVLERNETGLSSYFRPPRENSISEEESSIRTQIANRAAYDSEPYHDIENNEDMKSPGYPDGPLPIYDDNVFLYLEPTAEEASRFDVVINVAREVRNPFEKLSQSEPTTDTKERPEDDSPVPDTATTDASFCTAREYPSSDASSDSPTTPKAQKILKVPEYIHVPWDHNTDIVPDLMRLCETIEQRTKEGKKVLVHCQQGASRSASLIIAYGLYRNPELSVNDAYYQAQAKSRWISPNMRLMYCLQDFQKEVAKKKRLSPTGALKQRSGRSPTKHRATMSADNIGVTPPEPLTAPLPEDSGSRRTSPERTPNRPRGMTTPRPGEPISPGPSSAPSSFSWSEKEDESDPGKFGRFHIPERPAPPKEETKLAPPIESFSQPLRSPGLPPPSFGEQALRPPSSPGLPLSQHTTRPPPSPRLPPPQVSTRARTPPPPIKVGPPLRSIKIEAPQPSPGLIGLPKSPGFAPPEILEPPMSPGFRLAKPPPSPGFGARRFGLGQANRLTFGSLNCLGASPLKQEANETEEKKEPETIRVVQQQHQQQQQHQQKQEQSQQPKKHITAILPSFADEPLMSPRAETMTSNPIHERLAAVSSGASGLGGVAGTGLQFVEIPPTPRDGVFSPRATLFPRDPLYPFGRPMQAADPRSPPTKGETPIVRSIDEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G0S615</accession>
    <name>G0S615_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">U1 small nuclear ribonucleoprotein 70 kDa-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0025670</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693027.1">
        <property type="nucleotide sequence ID" value="XM_006692964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S615"/>
    <dbReference type="STRING" id="759272.G0S615"/>
    <dbReference type="GeneID" id="18256605"/>
    <dbReference type="KEGG" id="cthr:CTHT_0025670"/>
    <dbReference type="eggNOG" id="KOG0113">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045151_0_1_1"/>
    <dbReference type="OMA" id="GRTTKGW"/>
    <dbReference type="OrthoDB" id="4207594at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12236">
        <property type="entry name" value="RRM_snRNP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000298">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034143">
        <property type="entry name" value="snRNP70_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051183">
        <property type="entry name" value="U1_U11-U12_snRNP_70-35kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022023">
        <property type="entry name" value="U1snRNP70_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952:SF5">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12220">
        <property type="entry name" value="U1snRNP70_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="102"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="196"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="237"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="291"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="356"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS20731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="387" mass="43213" checksum="63B7C5EBEBE74FC7" modified="2011-10-19" version="1">MTDRLPPNLLALFAPRPPLRWVPPIDLPPEQRKTAPIGGLAQYLPKIAEYEREYEYHPTESWLERRDRKKREKAEALKKLLEEGPKNYNPHADPNIRGDAFKTLIVARLSYEADEKDLEREFGRFGPIERIRLIRDTHAHEKPNKKIKPHRGYAFVVFEREKDMRAALEGCDGIRIKGRLIKVDVERGRTVKGWKPRRLGGGLGGRGYTKQAASRPMGPGGFGGGFRGGYGGGFRARDRGFRGGSGGGDRGFRGGSGGGSSYSGRDRDRDRGYGSPNGGPPGAPSGPRDGYGSRDSRDRRDGRDGRDGSRYDDRYGGSSYRGDRAPRQTGSNAEPLRPRGSASGGDSGGYYGSSSGHRDYDRPREDDYSRKRSYEGSYEDPRKLRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0S657</accession>
    <name>G0S657_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nodulin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0034260</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693861.1">
        <property type="nucleotide sequence ID" value="XM_006693798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S657"/>
    <dbReference type="GeneID" id="18257464"/>
    <dbReference type="KEGG" id="cthr:CTHT_0034260"/>
    <dbReference type="eggNOG" id="ENOG502RWDV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012596_0_1_1"/>
    <dbReference type="OMA" id="PDGLGCY"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF158">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 12-LIKE CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="541"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="204"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS21565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="578" mass="61947" checksum="089E6A753A3B51F9" modified="2011-10-19" version="1">MKDRDRELHRARVVSSVAATIISLACGTNYVYSAWAPQFADKLHLTTTESNLIGLAGNLGMYSMGVPIGLFVDHRGPRPAVIAGSLLLAFGYFPISAAFETGSGSVPVLCVFSFLTGLGGCMAFNAAVKTSALNWPHHRGTATAFPLAAFGLSAFFFSLLGGLLFPGNTSAFLSLLAIGTFFMTFAGYFFLKVYPHTSYHSLSAGDPTSTGSQRLHRTPSSDRAKAARHPGHSHYRSLGSEPGRSPTSYTTPLADESAGAVEGAQPLQESVCAGSSKDTGPVPRTLDETDVEVVLPIQSSDTAFHEVDETSSLMSKSSSPSSSLAGDVLVQNSVDLDRSHRIDIRGLRLLRNLDFWQLFAILGVLAGIGLMTINNIGHDVNALWKKFDAKVTEGFLVKRQQMHVSILSVGSFIGRLLSGIGSDYLVKSLQASRAWCLVIAGGLFCIAQLCAVNIENPHFLGFVSGLSGLGYGFLFGVFPSIVAEAFGIHGLSQNWGFMTLSPVISGNIFNLFYGVVFDSHSIVGPDGDRTCPDGLDCYKNAYYVTLVASWFGIAVTLMTIRNQYRQRLNEEGKVAAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>G0S691</accession>
    <name>G0S691_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Putative resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CTHT_0025910</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693051.1">
        <property type="nucleotide sequence ID" value="XM_006692988.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S691"/>
    <dbReference type="GeneID" id="18256629"/>
    <dbReference type="KEGG" id="cthr:CTHT_0025910"/>
    <dbReference type="eggNOG" id="KOG0054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_27_1_1"/>
    <dbReference type="OMA" id="CFETGMR"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042592">
        <property type="term" value="P:homeostatic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18595">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18603">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000565">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000020">
        <property type="entry name" value="ABC metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000450">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000001">
        <property type="entry name" value="ATP-binding cassette subfamily C member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="546"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="579"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="988"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1032"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1120"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="16">
        <location>
            <begin position="320"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="642"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="16">
        <location>
            <begin position="995"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="1313"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="868"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="872"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="910"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="951"/>
            <end position="969"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGS20755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1571" mass="174923" checksum="0DD08D952892B3FF" modified="2011-10-19" version="1">MEAADDFYDDPFSSRHQKLLYQTGSFTGYYAGPQLGSGYLNAARSFRQPFCGNEEGWGPLSPFRYDFTPCFIDVWVATVAVFGILAGTAAVWWLLKKKQSGPVSKDWHFWTKQTLLVFIIADVAVQLALQISNFPDIWYGDFRVYTTVATILSLFVVFTIQWLEHSRLRNANGVVLFYWLLLLITLSVKLRSLISQQIYATSLPYFVTYCVGFGLSVAEFFFEWLWPKKQDAYSVLIEEDECPVEHATVFSRLTFSWLTPLMKQGYATYLTEEDLWALSRTDTTKATGAAFEKAWEYELEHHKKPNLWRALFRAYGGPYILASFFKIGNDISQFTQPQLLRFLIAFIYSYRIEEPQPVIKGAAIALAMFAVAVFQTTMIHQYFQLAFVTGMRIKSGLTSSIYKKALKLSNEGKSSKTIGDIVNYMAVDAQRLQDLTQFAQQLWSAPFQIIICMVSLYQLVGWSMLAGIAVMIIMIPVNGVIARYMKNLQKQQMKNKDARSRLIAEIVNNMKSIKLYAWGAAFMNKLNYIRNDLELKNLRKIGAGQAFANFTWSSTPFLVSCSTFAVFVLTGDRPLTTDIVFPCLALFNLLTFPLAVLPMVITSIIEASVAVSRLTSYLTAEEIQPEAVIVKPPVEQIGEETVRIEDGTFSWNRHENKTVLKDINFKAAKGELTCIVGRVGAGKSSFLQSILGDLWKVKGRVEVHGTVAYASQSPWIMNATVRENIVFGYRFDAEFYEKTVKACALLDDFAQLPDGDETVVGERGISLSGGQKARVALARAVYARADVYLLDDVLSAVDSHVGRHIIDNVLGPRGLLKSKTRVLATNSIPVLVESDYICMLKDGEIVERGTYNELLSNKGLVFDLVKTAGKGDSTQNSGSATPRESESETSTVIEASSNGQDKDDLEETQEGLSALQSIRPGPSSSQSKPRADSMATLRRASAASFNGPRGKLHDEENPNSRTKQAKEHSEQGKVKWSVYAEYAKTNNLVAVTFYLFALIAAQTANIAGSVWLKEWAETNTSVGGNPDIGKYLGIYFVFGIGAAALTVIQTLILWIFCSIEASRKLHERMATAIFRSPMSFFDVTPAGRILNRFSSDIYRVDEVLARTFNMLFNNLARSGFILGVISVSTPPFVALIFPLGAMYYWIQRYYLRTSRELKRLDSVTRSPIYAHFQESLGGISTIRAYRQQDRFQLENEWRVDANLRAYFPSISANRWLAVRLEFIGAVVILAAAGFSVVSVASGAPLTEGMVGLAMSYALQITTSLNWIVRQTVEVETNIVSVERVLEYARLPSEAPEIIHRSRPPVSWPSRGEVQFNNYSARYREGLDLVLKNINLDIKSHEKIGVVGRTGAGKSSLTLALFRIIEPATGNICLDGLNTSTIGLLDLRRRLAIIPQDAALFEGTIRDNLDPGHVHDDTELWSVLEHARLKDHVASMEGGLEAKIHEGGSNLSQGQRQLVSLARAMLTPSNILVLDEATAAVDVQTDAMLQQTLRGPLFANKTIITVAHRINTILDSDRVVVLEKGEVVEFDTPKELVKKRGVFYGLVKEAGLLEEFEKGETGGKAGQGSDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0S699</accession>
    <name>G0S699_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tafazzin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0025990</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a cardiolipin + a 1-acyl-sn-glycero-3-phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:33731"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="ChEBI" id="CHEBI:62237"/>
            <dbReference type="ChEBI" id="CHEBI:64743"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:33732"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:33733"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion outer membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the taffazin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693059.1">
        <property type="nucleotide sequence ID" value="XM_006692996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S699"/>
    <dbReference type="SMR" id="G0S699"/>
    <dbReference type="STRING" id="759272.G0S699"/>
    <dbReference type="GeneID" id="18256637"/>
    <dbReference type="KEGG" id="cthr:CTHT_0025990"/>
    <dbReference type="eggNOG" id="KOG2847">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046747_1_0_1"/>
    <dbReference type="OMA" id="IMRYFKW"/>
    <dbReference type="OrthoDB" id="193467at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000872">
        <property type="entry name" value="Tafazzin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497:SF0">
        <property type="entry name" value="TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497">
        <property type="entry name" value="TAZ PROTEIN TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00979">
        <property type="entry name" value="TAFAZZIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="13">
        <location>
            <begin position="65"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS20763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="378" mass="42921" checksum="91A9E242BB62FCE6" modified="2011-10-19" version="1">MSASSPVPQRPSLSWQIKSALVMGMTGVISRVFLYGFNKVEVHGLDRFLELLDSRKDPANRKHGLLTVSNHISVVDDPVVWGLLPLTKYAFNPDNLRWTLGAADICFKNKLFASFFTVGQVLPCHRLKHSPYGGPFQPALTQAIRLLSTPNPLLSSNSPTSLPLTYTTDGTDTHPSPLSFPKLRRHAWVHVFPEGLVHQHASTDLRYFKWGAARLILESDPVPDIVPMFIDGTQRVMPEDRGFPKFLPRIGKKVRVVFGEVVDYERTFGDLKRQWDALVERERKRLVKEGGEKAMILLKQMMPGELPTDELKYGKEAREIRIEVARRLREEVLRLRRELGGYPEPDPSFAFAETWRPDDVIGAKKYKSRVDGSNINQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6C4</accession>
    <name>G0S6C4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Synaptobrevin homolog YKT6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0026260</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693084.1">
        <property type="nucleotide sequence ID" value="XM_006693021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6C4"/>
    <dbReference type="STRING" id="759272.G0S6C4"/>
    <dbReference type="GeneID" id="18256664"/>
    <dbReference type="KEGG" id="cthr:CTHT_0026260"/>
    <dbReference type="eggNOG" id="KOG0861">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074848_0_1_1"/>
    <dbReference type="OMA" id="HYIGIIR"/>
    <dbReference type="OrthoDB" id="27923at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15867">
        <property type="entry name" value="R-SNARE_YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000020">
        <property type="entry name" value="synaptobrevin homolog YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045848">
        <property type="entry name" value="R-SNARE_YKT6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806:SF1">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0564">Palmitate</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Longin" evidence="10">
        <location>
            <begin position="8"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="138"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS20788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="198" mass="22240" checksum="B2CEB7A26DAFB4E9" modified="2011-10-19" version="1">MKLYYVGVLDNTKRPAVQLCAAHELSEFSRWTKNEYAAFMTMISKTVAERTNPGQRQSVEEGDYVVHCYARTEGVAGVVITKDYPHIAAHSVLSKLMDQFLSENPLDKIRSASKDGDINWPAVNDFLNNYQNANEASSIARIQQELDETKIILHKAIDSVLQRGEKLDDLVAKSSDLSAQSKMFYKSAKKQNSCCLVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6G8</accession>
    <name>G0S6G8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0034870</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693919.1">
        <property type="nucleotide sequence ID" value="XM_006693856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6G8"/>
    <dbReference type="GeneID" id="18257525"/>
    <dbReference type="KEGG" id="cthr:CTHT_0034870"/>
    <dbReference type="eggNOG" id="KOG0013">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054816_0_0_1"/>
    <dbReference type="OMA" id="GCMGRYL"/>
    <dbReference type="OrthoDB" id="1640476at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.225.20">
        <property type="entry name" value="Ub domain-containing protein, DC-UbP/UBTD2, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032752">
        <property type="entry name" value="DC-UbP/UBTD2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038169">
        <property type="entry name" value="DC-UbP/UBTD2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039869">
        <property type="entry name" value="UBTD1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13609">
        <property type="entry name" value="UBIQUITIN DOMAIN CONTAINING 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16455">
        <property type="entry name" value="UBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="237"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS21623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="314" mass="35052" checksum="38881DD3D4764349" modified="2011-10-19" version="1">MGCCLSREGDAHSPYSGGDATGSSRAINEEAQAAGSSGSNTGYDDSSSRRRRRYSHQPLAQHINKPLRRHDWTSHDRLWTPAALRRERIEFFDTRVSGRQEIWQTIHAALEVLWAADEVARKGQSQRLSEDGGPSEDDPATALMTAQSILDAAEITLPTGDLHDGAYDAFGNFYQLPRHIISDPTNLVWRPGMTEDDDLEDTKADLSGGETCEEREDADEAERRRVEKGKAVIDIRDQITVKARLSDTSQDVVVFADKKDTVRRIARLIAEEAQLPSNKKIRIAYMGKILQENSPLEAQGWKQGHVVNALVFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6K9</accession>
    <name>G0S6K9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Transmembrane GTPase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0026580</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
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                <person name="Niu S."/>
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                <person name="Hurt E."/>
                <person name="Cheng J."/>
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                <person name="Cheng J."/>
                <person name="Fromm L."/>
                <person name="Denk T."/>
                <person name="Kellner N."/>
                <person name="Flemming D."/>
                <person name="Fischer P."/>
                <person name="Falquet L."/>
                <person name="Berninghausen O."/>
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        <property type="method" value="EM"/>
        <property type="resolution" value="2.19 A"/>
        <property type="chains" value="Le=1-131"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6V4"/>
    <dbReference type="EMDB" id="EMD-12976"/>
    <dbReference type="EMDB" id="EMD-12977"/>
    <dbReference type="EMDB" id="EMD-14479"/>
    <dbReference type="EMDB" id="EMD-14480"/>
    <dbReference type="EMDB" id="EMD-17004"/>
    <dbReference type="EMDB" id="EMD-17950"/>
    <dbReference type="EMDB" id="EMD-17951"/>
    <dbReference type="EMDB" id="EMD-17952"/>
    <dbReference type="EMDB" id="EMD-17953"/>
    <dbReference type="EMDB" id="EMD-17954"/>
    <dbReference type="EMDB" id="EMD-17955"/>
    <dbReference type="EMDB" id="EMD-17956"/>
    <dbReference type="EMDB" id="EMD-17957"/>
    <dbReference type="EMDB" id="EMD-17969"/>
    <dbReference type="EMDB" id="EMD-17970"/>
    <dbReference type="EMDB" id="EMD-35279"/>
    <dbReference type="EMDB" id="EMD-35281"/>
    <dbReference type="EMDB" id="EMD-35283"/>
    <dbReference type="EMDB" id="EMD-35285"/>
    <dbReference type="EMDB" id="EMD-35286"/>
    <dbReference type="EMDB" id="EMD-35287"/>
    <dbReference type="EMDB" id="EMD-35288"/>
    <dbReference type="EMDB" id="EMD-35289"/>
    <dbReference type="EMDB" id="EMD-35290"/>
    <dbReference type="SMR" id="G0S6V4"/>
    <dbReference type="STRING" id="759272.G0S6V4"/>
    <dbReference type="GeneID" id="18256738"/>
    <dbReference type="KEGG" id="cthr:CTHT_0027000"/>
    <dbReference type="eggNOG" id="KOG0878">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071479_4_0_1"/>
    <dbReference type="OMA" id="HPSGYEE"/>
    <dbReference type="OrthoDB" id="268693at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00513">
        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_eL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_eL32_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L32 AND DNA-DIRECTED RNA POLYMERASE II, SUBUNIT N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="Ribosomal protein L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6 7 8" id="KW-0002">3D-structure</keyword>
    <keyword evidence="6 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="binding site" evidence="6 8 9">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS20862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="7OLC"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="7OLD"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="7Z3N"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="7Z3O"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="8I9P"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="8I9R"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="8I9T"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="8OO0"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="8PV1"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="8PV2"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="8PV3"/>
        </source>
    </evidence>
    <sequence length="131" mass="15057" checksum="A1FF2B59C1E3E719" modified="2011-10-19" version="1">MVAAKKHVPIVKKRTKRFMRHQSDRFKCLDSAWRKPKGIDNRVRRRFKGNLAMPSIGYGSNKKTKHMMPSGHKAFLVHNVKDVELLLMHNRTYAAEIAHNVSSRKRIDIITRAKQLGVKVTNAKAKVTTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6W6</accession>
    <name>G0S6W6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ADP-ribosylation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0027120</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693170.1">
        <property type="nucleotide sequence ID" value="XM_006693107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6W6"/>
    <dbReference type="STRING" id="759272.G0S6W6"/>
    <dbReference type="GeneID" id="18256750"/>
    <dbReference type="KEGG" id="cthr:CTHT_0027120"/>
    <dbReference type="eggNOG" id="KOG0072">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040729_9_3_1"/>
    <dbReference type="OMA" id="MGAGMSW"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04151">
        <property type="entry name" value="Arl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000624">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS20874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="180" mass="19912" checksum="0A547E976CDC496B" modified="2011-10-19" version="1">MGQSISWLSSLFWSKKEIRILILGLDNAGKTTLLYRLKIGEVVTTIPTIGFNVESVTYKNLNFNVWDLGGQTSIRPYWRCYYANTAAVIFVVDSTDIERLQTAADELAAMLNEEELKDAALLVFANKQDQPGAKGAADISQALRLGELRDRNWSIMACSAVEGTGITEGMDWLAQTVAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0S736</accession>
    <name>G0S736_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytocyanin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0036010</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694030.1">
        <property type="nucleotide sequence ID" value="XM_006693967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S736"/>
    <dbReference type="GeneID" id="18257639"/>
    <dbReference type="KEGG" id="cthr:CTHT_0036010"/>
    <dbReference type="eggNOG" id="ENOG502S40X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025344_0_0_1"/>
    <dbReference type="OMA" id="SFDKPCQ"/>
    <dbReference type="OrthoDB" id="5415867at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF15">
        <property type="entry name" value="EXTRACELLULAR SERINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS21734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="52245" checksum="F03ED880AAA7550D" modified="2011-10-19" version="1">MGGIRRIEVDVGKGGRLEFVPSKIMEPVGTVVRFNFDPKNHSVTESSFDNPCQPIEGGFSSGFIPTQSSPSGVTFDYTIVDDKPKWFYCGQGTHCQSGMVGSINAPTVESNSGRTHEDFVAKAQQAPPPSKVPPNAPLGGTLTVNGTIVTSLNGNVLPDKLDGLPTTTAPPIPIGTGDLPPPGIEAPDYYAEKAGGGKPTHWNWAPSFSDEAAAYLQFHSRIEDLLLHLLWDGHRKLEAGGAWAGVYPAAIVKTIGAWAAQSLIHRATTGEILAHYNRSIPASCKYILPSVTSSVNDFIAAFSALNNLQIGVLTDMSVHLAKADPFVVPFLLSQAGAKSRAGAVVSMIRNHLAASAPREIGLPAKLAWSYVMNHFVDHCPDKLAGMPDQPWKVLEATLKVEERAVSVQLKYEGGVPDGKAHYVAWIGPYGSLEFTELDEENMTSIVPGKMYGDIWIVVVDKDDLQLAEIPDHLVAGPQLVWIDDPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0S768</accession>
    <name>G0S768_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CTHT_0027620</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 21">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family. DDX48/FAL1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693219.1">
        <property type="nucleotide sequence ID" value="XM_006693156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S768"/>
    <dbReference type="STRING" id="759272.G0S768"/>
    <dbReference type="GeneID" id="18256800"/>
    <dbReference type="KEGG" id="cthr:CTHT_0027620"/>
    <dbReference type="eggNOG" id="KOG0328">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_0_1"/>
    <dbReference type="OMA" id="TRFHDFK"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18045">
        <property type="entry name" value="DEADc_EIF4AIII_DDX48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000498">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15 19" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="18">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="57"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="238"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="14">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGS20923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="400" mass="45542" checksum="65CB0D220130FDAA" modified="2011-10-19" version="1">MVEGGIDRKADEKIQFTTSKEVTVHPTFESMNLKESLLRGIYAYGYESPSAIQSRAIVQICKGRDTIAQAQSGTGKTATFSIAMLQVIDTAVRETQALVLSPTRELATQIQNVVMALGDYMNVQCHACIGGTNVGEDIRKLDYGQHIVSGTPGRVADMIRRRHLRTRHIKMLVLDEADELLNQGFREQIYDVYRYLPPATQVVVVSATLPYDVLEMTTKFMTDPVRILVKRDELTLEGLKQYFIAVEKEEWKFDTLCDLYDTLTITQAVIFCNTRRKVDWLTEKMREANFTVSSMHGDMPQKERDAIMQDFRQGNSRVLISTDVWARGIDVQQVSLVINYDLPSNRENYIHRIGRSGRFGRKGVAINFVTSEDVRILRDIELYYSTQIDEMPMNVADLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0S796</accession>
    <name>G0S796_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0036070</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694036.1">
        <property type="nucleotide sequence ID" value="XM_006693973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S796"/>
    <dbReference type="STRING" id="759272.G0S796"/>
    <dbReference type="GeneID" id="18257645"/>
    <dbReference type="KEGG" id="cthr:CTHT_0036070"/>
    <dbReference type="eggNOG" id="ENOG502S025">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_0_2_1"/>
    <dbReference type="OMA" id="PVAKYWD"/>
    <dbReference type="OrthoDB" id="3648173at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF123">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="35"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="279"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="342"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS21740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="371" mass="41152" checksum="E9E005F2040BC06C" modified="2011-10-19" version="1">MAVWYIGGMEVVERNHALVVNSFFWTILAFIIVVLRLFTRGYVIKRIGPDDWLMAGAMVASIGFLIAEMYQIKWGLGKPVNPATLIQFLAALYATIPLYNLSQTLYKLSVATQLYRLFNTPKNQLKIKIMFAWILLCGMYTVLGCLFYCSPVKKAWDVFVPGTCMDRDVLHYTISALNILNDLLLIAVPLYFVLKLQIPKKQRLVLASIFSCGAFVTIVSIIRLKALHENVTGPEVDQPITGVNIALWSHLDINVAIIFLSLPALQALITRYILKKHYSGSDSHSGATGAVTGSGPGSRVLRSHATRNDDLDYEAGDRMAIHVQQSIEMKSYAIDDTGSEKDLIDKQNFGPTNYTTISAGGNNPKSNQSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7Y7</accession>
    <name>G0S7Y7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Magnesium-dependent phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0037470</name>
    </gene>
    <organism evidence="2">
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    </organism>
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        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
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            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
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    </dbReference>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <sequence length="210" mass="23609" checksum="68EDAF848CD805D2" modified="2011-10-19" version="1">MAKSKRLAPRAPGADSTFSLPAWATDGLPLPRMVVFDLDYTLWPFYSDIHISPPVRAVPNTQSSVLADRNGEQFGLYPDAPYIIRLLQSLKIRLAVASKSPVGDLCREVLKQLRLPEDSPGVESSSSKKLRVIDAFDGGLEIYEGTKIRHFEVIARRTGVPFNEMLFFDDERPNLEVERLGVTMRLIRDGLTWDELEKGIAQWRANRGIA</sequence>
</entry>
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            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
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                <person name="Sarges P."/>
                <person name="Flemming D."/>
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                <person name="Kunze R."/>
                <person name="Devos D.P."/>
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        <citation type="journal article" date="2019" name="Mol. Cell" volume="75" first="1256" last="1269.e7">
            <title>Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration.</title>
            <authorList>
                <person name="Cheng J."/>
                <person name="Bassler J."/>
                <person name="Fischer P."/>
                <person name="Lau B."/>
                <person name="Kellner N."/>
                <person name="Kunze R."/>
                <person name="Griesel S."/>
                <person name="Kallas M."/>
                <person name="Berninghausen O."/>
                <person name="Strauss D."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="31378463"/>
            <dbReference type="DOI" id="10.1016/j.molcel.2019.06.032"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.50 ANGSTROMS)</scope>
    </reference>
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        <property type="entry name" value="Sas10/Utp3/C1D"/>
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    </dbReference>
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    </dbReference>
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        </location>
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        <location>
            <begin position="286"/>
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        <location>
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        </location>
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        <location>
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        <location>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PDB" id="6RXV"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PDB" id="6RXZ"/>
        </source>
    </evidence>
    <sequence length="381" mass="42547" checksum="2D436FB063F54DC1" modified="2011-10-19" version="1">MAAPTTLPALLDTLTRSLTSTLEVAPKLQSLELPKDGISLLDVKNELLLSYLQNIVFLILIKLREAKYSARSERKSDEQSLSDLVVRKLVELRLYLEKGTRPLEDKLRFQIDKVLRAADDAERKAKAAEEAEKAKCQKSDDESSSESQSDSEEEESGDMDSKVNGLSGARTEDLLHRPNLSNFQRPAAATKVTKEKDNSGVYRPPRIAPIAMPTNDRRDKAERRPLKSATLDEFIADEVSTAPIAEPSIGTNIVKRGRGLKTAAERRMEEERREYEETNFVRLPKESKKERAKRARMEGRSGRMNFGGEEFRELGEGAERISRLTKAKSSGGGTKALLEKSRKRTIDTVNGSRGSGVAMGERYQKRLKVLESGRGTRGKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8F8</accession>
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        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0029730</name>
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    <organism evidence="10">
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
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                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
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        <text evidence="2">Belongs to the EAF7 family.</text>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Eaf7/MRGBP"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13581:SF5">
        <property type="entry name" value="MRG_MORF4L-BINDING PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF07904">
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="10"/>
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        </location>
    </feature>
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        <location>
            <begin position="185"/>
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        </location>
    </feature>
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        <location>
            <begin position="206"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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    </feature>
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        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
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        <location>
            <begin position="301"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS21132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="374" mass="39867" checksum="2E143E121E68BBB8" modified="2011-10-19" version="1">MPPKKKAARASTQSATPATTDGGGEAMEIDSTVQTPTTPAAPQPSQPKSPLKLVTDPWTDDQMASLFKGVIRWKPAGMHKHFRMLAISEHLRNHGFDPDQHPHTRIPGIWAKLGEYYNLEAVDERENQMDPPEEMEEGGQRRYVDFTLPWEEYGEMILERARKEPSEAPTSPAQWDPNAPPGSYASGATTTTTTTTTTAAAAAAAAGGGGGGGESQGTAAQPTTMTGTTKKRKRGEAQAQTRTRSSTVEDTENETPTASPTRKGTTGKGARGARGAGTATKRTTSKARKVKEESPSSSSESSEEEEEEEEGEGEEEGEGEEEEEDSSSSSEEEEEEEEEEETGATAARTGRGGGRGRGARGRGRGRGRGRGRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8L2</accession>
    <name>G0S8L2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipase</fullName>
            <ecNumber evidence="5">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0038480</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the phospholipase D family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="5"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694268.1">
        <property type="nucleotide sequence ID" value="XM_006694205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8L2"/>
    <dbReference type="STRING" id="759272.G0S8L2"/>
    <dbReference type="GeneID" id="18257886"/>
    <dbReference type="KEGG" id="cthr:CTHT_0038480"/>
    <dbReference type="eggNOG" id="KOG1329">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000690_2_2_1"/>
    <dbReference type="OMA" id="ILYWAHH"/>
    <dbReference type="OrthoDB" id="14911at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09138">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016555">
        <property type="entry name" value="PLipase_D_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF186">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009376">
        <property type="entry name" value="Phospholipase_D_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="6">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="6">
        <location>
            <begin position="626"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR009376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS21972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="862" mass="98362" checksum="310F79F9C8DF176A" modified="2011-10-19" version="1">MSFGSFLKKAKDGLKDVKQGLQDLDKVKENLGKMSISDVGKIFGGDDKHSHTHDGVECHEGASHGEYGANRYSSFAPETTGRAKWYVDGASYFWALSMALEEAREYIYILDWWLSPELYLRRPPSRNNRYRLDHMLKAAAERGVKVYVIVYKEVPQALTLNSDHTKKALRALHPNIFVFRHPDHHPGNDVVTGLQDFHKSLMNFSFKNFNLAKASEDVLKGLYGTADDVVLYWAHHEKLCLIDGKIAFMGGLDLCFGRWDTISHPIADAHPGNVDDIIFPGQDYNNARVFDFENVDKWEQNKLDRSRFSRMGWSDIALSLTGPIVESLETHFVQRWNFIFNKKYSTKDPGKYERLEVRSHQRQSHHGHGHGHGMAYTAQSFLDEGTEYLRNEMHQRFSRLSHHFFGEEEHGRPRRSYEGPRGQQIQLTRSACNWSLGVKTEHSIANAYIDAIKNARYHIYIENQFFITATSDKQKPVTNKIGKAIVDRILRAHQYNEPFHIVVIMPAVPAFAGDLKSDGALGTRAIMEFQYFSINRGGYSILETLQKAGVEDPSRYITFYNLRSFDRINTNTPGDSQYRRYNYAASQLSHYSWDSIAACYMDNGPDLNAIPWTGPPEKEMDAYVSEQLYIHSKLLIADDSLVICGSANLNDRSQLGNHDSEIAVVITDANPSLDTTMAGYPHRASHFAASLRRFVFRKHLGLLPHQPVDQPDRNWTPVTHDPVNEYDWGSDADCLVADPLSPRFMDLWRTTARRNTEIFSRAFHPVPDDKVRTWKDYEEFFSKYFVNPGESAEKQAEGYKQGKVDYGHVVKEEFPGGVEELKAWLSGVRGTLVEMPLGFLADEEDIAKEGLALNSLTQELYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9F5</accession>
    <name>G0S9F5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitrilase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0045700</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694951.1">
        <property type="nucleotide sequence ID" value="XM_006694888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9F5"/>
    <dbReference type="STRING" id="759272.G0S9F5"/>
    <dbReference type="GeneID" id="18258608"/>
    <dbReference type="KEGG" id="cthr:CTHT_0045700"/>
    <dbReference type="eggNOG" id="KOG0807">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030130_1_2_1"/>
    <dbReference type="OMA" id="KRESWGH"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07572">
        <property type="entry name" value="nit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045254">
        <property type="entry name" value="Nit1/2_C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF27">
        <property type="entry name" value="DEAMINATED GLUTATHIONE AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS20066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="245" mass="27433" checksum="6D8EC57A0B996322" modified="2011-10-19" version="1">MALIALFLPEATDYIASNGEETVKLAQPVDQSEFVLGLREEARREKLPIHVGIHEPGNDRRKVKNTVLWIDERGEIAHRYQKIHLFDVDIKDGPVLKESSSVERGNKILPPFDTAVGKVGSAICFDLRFPEISLSLRRLGADIITYPSAFTVPTGKAHWEVLLRARAIETQSYIVAAAQVGKHNDKRISYGHSMIVDPWGKIVAQLGGDQGLEPEIATAEIDHELLRKVRMEVPLTRRTDVYPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9F9</accession>
    <name>G0S9F9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0045740</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694955.1">
        <property type="nucleotide sequence ID" value="XM_006694892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9F9"/>
    <dbReference type="GeneID" id="18258612"/>
    <dbReference type="KEGG" id="cthr:CTHT_0045740"/>
    <dbReference type="HOGENOM" id="CLU_1618812_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="164" mass="18391" checksum="BDF0A0AD2FB92142" modified="2011-10-19" version="1">MSTVAFKPNHLAVFGAAAAGGAGGQPPRRPNFNPKPLDDDGDLELNHQEEEGVSAGDEDNDSPDDAAEEGFQERRRAGGGAFPPNSLPNHPLKHKKDPIRQKKQREKNKKKSKTGKRTYLKEPDTFDWRVRAGLWLMGTTPEKIMVKVKEQERKRERGSEHDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9N6</accession>
    <name>G0S9N6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative mitochondrial outer membrane beta-barrel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0046540</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAM50/omp85 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695032.1">
        <property type="nucleotide sequence ID" value="XM_006694969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9N6"/>
    <dbReference type="STRING" id="759272.G0S9N6"/>
    <dbReference type="GeneID" id="18258692"/>
    <dbReference type="KEGG" id="cthr:CTHT_0046540"/>
    <dbReference type="eggNOG" id="KOG2602">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014798_3_1_1"/>
    <dbReference type="OMA" id="KHPVARF"/>
    <dbReference type="OrthoDB" id="1724197at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.50:FF:000008">
        <property type="entry name" value="Mitochondrial outer membrane beta-barrel protein Tob55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.50">
        <property type="entry name" value="membrane protein fhac: a member of the omp85/tpsb transporter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815:SF18">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY COMPONENT 50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY SAMM50 PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="domain" description="Bacterial surface antigen (D15)" evidence="6">
        <location>
            <begin position="162"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS20147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="510" mass="54059" checksum="8A56BCF2E6904695" modified="2011-10-19" version="1">MASSLGSGGSNAAADLATKTSSETSLKQLYQGPAQVLSEHLLTPASINTLEVHGATNTRRGLLDHIFKPVVDDSSAPETTLGQVLERLGTATRKLGRFDIFKEDGFNVFLSEAPRPEGAPASERTDLDISIQVKEKSRLVFSAGTDFGNLEGSAYTNAVARNIFGGAETLTINASTGTRTRSAYNAVFSTPINGNPDLRLNLEALRSSTQKPWASHDEHVTGGTLRFAWLTPDNDTHALSYSAAWRQITSLAATASPTVRADAGDSFKSSLTHTFVRDRRDNPLLPQSGYLFRTVSELAGWGPLRGDVSFAKTELEASAAVPFSLLKGVSLGGAFRFGLLYPLPMGYSLTGRAQPSRINDRFLLGGPTDVRGFKLGGIGPHDGADSVGGDVFAAGAVNMLLPLPRAGAESPLRLQLFANAGRLVGLNTKKSGKDGKEGKGLGMESRTVYRSVNAALSELTNGLPSVAAGFGLVYAHPVARFELNFSLPLVVRRGEEGRKGLQVGVGINFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9T5</accession>
    <name>G0S9T5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0047100</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695081.1">
        <property type="nucleotide sequence ID" value="XM_006695018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9T5"/>
    <dbReference type="GeneID" id="18258748"/>
    <dbReference type="KEGG" id="cthr:CTHT_0047100"/>
    <dbReference type="HOGENOM" id="CLU_2468866_0_0_1"/>
    <dbReference type="OrthoDB" id="4567934at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="88" mass="9408" checksum="C5D0A1D5DF4466F6" modified="2011-10-19" version="1">MTQITQEPVRQTPMKAAASNPAPLPLADGHSEQTGAGAMNAQVVTSQPKPLNPMSTEDPELTLRGGDLYCGFSRGCCGFTCSWYKRCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9Y5</accession>
    <name>G0S9Y5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Alkaline protease-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0040330</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694442.1">
        <property type="nucleotide sequence ID" value="XM_006694379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9Y5"/>
    <dbReference type="MEROPS" id="S08.061"/>
    <dbReference type="GeneID" id="18258071"/>
    <dbReference type="KEGG" id="cthr:CTHT_0040330"/>
    <dbReference type="eggNOG" id="KOG1153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011263_1_4_1"/>
    <dbReference type="OMA" id="DNPPSWG"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000014">
        <property type="entry name" value="Proteinase K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF58">
        <property type="entry name" value="ALKALINE PROTEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409406" evidence="8">
        <location>
            <begin position="18"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="10">
        <location>
            <begin position="55"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="9">
        <location>
            <begin position="151"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS19557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="399" mass="41048" checksum="CCCE608F5D2CDE3B" modified="2011-10-19" version="1">MHFSTALLATLLPAVLAAPAPAGPIDRRAPILEARAGEVIPGKYIIKLKEGYSDDTLEKVLSRVGIKGKTDHIYKMRRFKGFAGKLDDKVLDAVRSLPEVEYVEQEAVYTINAYVSQTNAPWGIARISQKTSGKTTYVYDNSAGAGTCAYVIDTGIYTSHSDFGGRATFAANYVDNSNTDGNGHGTHVAGTIGGTTYGVAKKTKLYAVKVLNASGSGSTSGVVAGINFVASDHVNRNCPNGTVANMSLGGSYSASINNAANALVDAGVFLAVAAGNDNANAANYSPASAAKACTVAATDSSDRKASYSNYGSVVDVLAPGSNILSTWIGSTTAKNTISGTSMASPHVAGLGAYIMGLKGKMGGEALCTYIKNTALSGVISGFPSSTTNKFAFNGNPNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0SA66</accession>
    <name>G0SA66_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative specific RNA polymerase II transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0041170</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694523.1">
        <property type="nucleotide sequence ID" value="XM_006694460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SA66"/>
    <dbReference type="STRING" id="759272.G0SA66"/>
    <dbReference type="GeneID" id="18258155"/>
    <dbReference type="KEGG" id="cthr:CTHT_0041170"/>
    <dbReference type="eggNOG" id="KOG2588">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008057_1_0_1"/>
    <dbReference type="OMA" id="RVKTWDI"/>
    <dbReference type="OrthoDB" id="2133190at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11399">
        <property type="entry name" value="bHLHzip_scHMS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052099">
        <property type="entry name" value="Regulatory_TF_Diverse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019006">
        <property type="entry name" value="Sre1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09427">
        <property type="entry name" value="DUF2014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="3">
        <location>
            <begin position="330"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="394"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS19638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1122" mass="120623" checksum="37F46709205A1D49" modified="2011-10-19" version="1">MAGFDAATQTLLAALSGSSGLNNNFGLNPDDSLVDNFVDNGSGNGLGTPDANSVAATLGDTPASSGSAVPGARSGSGFGAVSAAGPGAGAGGSGTSSSVPPSAVTASLQLQQQPAFFNPVPPTQWVFQDTPPYDSPSSAGSPFGNVPPSAPQQSWELPVHHLNLAQQLLQPQPSPSPFFHPASTAVSSANVAAVAAATTANVPVTQSFAAPNLPVSEPETQRRIQNTLTPAQRERLKTITMPPHLQYHFPKSEGSPDSASSPQEAKGVTTASPTTLDPSKQNHDHASGTSHNADDNASNTNTNTNTRKRKSSADDDDDDDDEEIEVPPPVKKTAHNEIEKRYRTNLNDKIAALRDSVPSLRIMCKSARGEDTTEDREELHGLTPAHKLNKATVLSKATEYIKHLEKRNNRLIEEINSMQARIATFEKLFMAGAMTGQLPNPLQQTQPMQFNPASNPYMNNMNGMNMTAMNTPMATPQDANPPGMIPIPEDMKRIITAQQLNAGRPYPVPPAAAHFVQNPALLRQQHIQQQQQQAQARGWSPYFGKVMVGSLAGMMLIEALVENEKDRETTEGRGLFAIPVQLLAAFVRSTHFSIGGYYIDAKSIIAKLRLFTLLAIFLWVACSSFLDNMSFFRPPQKTKRAATAAAPVHFAPSLSSPLHVRRTAWLTAIQTVWVPQRNAFFEAAALLLKASKYALRCLIGDRAYLALTGLTEEQEAARVKAWSIALDAQLTGGDVDINKSRLTLTLFASGTLPDTPLRLMLKALHIRLLLWKLNGASWLANSVATTLARRKWNEARQLNQMIMSLVRKDTDDVLPEHLAVLLEQDCDDVLNDDIVQRAHNLAFNKPTTDDVMGGIPGMDSVVEDPAVRSPIDAVAAWYSTLLVHRALLNSLPKPQSPSDAAPAPTRSILNDVELAIKLAPIGSNAKVRALIARAVLVDGKRGTYIAAVLQALGPTTPYVKHTSAFLCTPYGLGALDADSHMALRCAMAMAQLGKFKGDLPRAAYMLIESILPHGCDIKTLSLLGYTAAFHLMEEISRHIKRDTCTDSMERLAGQLRIWIGSEEFGGGKVAGMTGEMRMRMVSRCLAVTKSVVGIQGAGCAVVDQGYVSMEDEDSLEDDGSGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G0SA85</accession>
    <name>G0SA85_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative 20S pre-rRNA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0041360</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TSR2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694542.1">
        <property type="nucleotide sequence ID" value="XM_006694479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SA85"/>
    <dbReference type="STRING" id="759272.G0SA85"/>
    <dbReference type="GeneID" id="18258174"/>
    <dbReference type="KEGG" id="cthr:CTHT_0041360"/>
    <dbReference type="eggNOG" id="KOG4032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074896_0_2_1"/>
    <dbReference type="OMA" id="QSNWGGP"/>
    <dbReference type="OrthoDB" id="263560at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019398">
        <property type="entry name" value="Pre-rRNA_process_TSR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21250">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10273">
        <property type="entry name" value="WGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="163"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS19657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="228" mass="25366" checksum="56D1B3AE3519A552" modified="2011-10-19" version="1">MATTAFPDPAQCQQNFEQAVALSLHLWPALTLAVQNEWGGPDSADKRDWFAGAIADLFPDVSRLTPAQLEQKLVQQAQLSPEQQASATVNGVKVDEPDQEDVEAVLLQVMLDEFEVAVEDDSAYEVAEQVVKLRKECLRGKFDGVEALRIKWEARGSSKNCGAVFQQVKNEDDEDEDDDDEDEETQDGDGDVEMEEAPELVATNGSRRERPEPVVDEDGFTLVTRKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAC0</accession>
    <name>G0SAC0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin conjugating enzyme-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0041730</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694577.1">
        <property type="nucleotide sequence ID" value="XM_006694514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAC0"/>
    <dbReference type="STRING" id="759272.G0SAC0"/>
    <dbReference type="GeneID" id="18258211"/>
    <dbReference type="KEGG" id="cthr:CTHT_0041730"/>
    <dbReference type="eggNOG" id="KOG0896">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_488316_0_0_1"/>
    <dbReference type="OMA" id="FEGRERW"/>
    <dbReference type="OrthoDB" id="6508832at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20273">
        <property type="entry name" value="Complex1_LYR_unchar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23807">
        <property type="entry name" value="UEV_UBE2V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000026">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046896">
        <property type="entry name" value="Cup1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="3">
        <location>
            <begin position="5"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="517"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="548"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS19692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="558" mass="63669" checksum="EBFD45014E5D59E9" modified="2011-10-19" version="1">MAKVPRNFKLLEELEKGEKGLGTAAVSYGLDDPEDMLLYNWNATIMGPPHGNHENRIYSLKVYCGDQYPDEPPKVKFLSKINLPGVNPTNGDVDPNAIQILRDWKRIAQDLANKPKPKHDPLCIESVLVAIRKHMDEHKKLPQPPEGLALYKSLLSQSLRVQIPPNTLQSLPPLPIHTPLTNETPLALLIRNGFRRNRSLTSPRLICSALKQGYRFLTLLTRAAEDPNSTEYASVVDFLQKNASRVEEIRAQREKEREKRRRFIEVVTTRKPGTGPLLKRVTPEGVRPPVYEPGIEWPRPLSIFPSGVRKPPTLVATSAGVPFLRFGGRQSRFLERVLRQKTNWRMEKIRILLDAQDEGMEWARDEDQWEELMGLLFLKENPDAVRELGQEDQMPDEPSYASSLHGMCAVLIDEIQAETEDQVARAKALWKMVLMEREQALKEAKEQLEREGKGDEEPQIKSWRRPVWEKKTPKWMREKGFDKKNARKAALEKRKENIRKAMEKFWWFKNAGEAAAVATGSKNTASQLPTVAEDPTKTKLGEASVGKRTTETEHSDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAE9</accession>
    <name>G0SAE9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0042030</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="15 16 17" key="2">
        <citation type="journal article" date="2022" name="Sci. Adv." volume="8" first="eadc9952" last="eadc9952">
            <title>Conformational changes in mitochondrial complex I of the thermophilic eukaryote &lt;i&gt;Chaetomium thermophilum&lt;/i&gt;.</title>
            <authorList>
                <person name="Laube E."/>
                <person name="Meier-Credo J."/>
                <person name="Langer J.D."/>
                <person name="Kuhlbrandt W."/>
            </authorList>
            <dbReference type="PubMed" id="36427319"/>
            <dbReference type="DOI" id="10.1126/sciadv.adc9952"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.44 ANGSTROMS)</scope>
        <scope>DISULFIDE BONDS</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFB7 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694606.1">
        <property type="nucleotide sequence ID" value="XM_006694543.1"/>
    </dbReference>
    <dbReference type="PDB" id="7ZM7">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.77 A"/>
        <property type="chains" value="8=1-86"/>
    </dbReference>
    <dbReference type="PDB" id="7ZM8">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.76 A"/>
        <property type="chains" value="8=1-86"/>
    </dbReference>
    <dbReference type="PDB" id="7ZMB">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.75 A"/>
        <property type="chains" value="8=1-86"/>
    </dbReference>
    <dbReference type="PDB" id="7ZME">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.83 A"/>
        <property type="chains" value="8=1-86"/>
    </dbReference>
    <dbReference type="PDB" id="7ZMG">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.44 A"/>
        <property type="chains" value="8=1-86"/>
    </dbReference>
    <dbReference type="PDB" id="7ZMH">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.47 A"/>
        <property type="chains" value="8=1-86"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAE9"/>
    <dbReference type="EMDB" id="EMD-14791"/>
    <dbReference type="EMDB" id="EMD-14792"/>
    <dbReference type="EMDB" id="EMD-14794"/>
    <dbReference type="EMDB" id="EMD-14796"/>
    <dbReference type="EMDB" id="EMD-14797"/>
    <dbReference type="EMDB" id="EMD-14798"/>
    <dbReference type="SMR" id="G0SAE9"/>
    <dbReference type="STRING" id="759272.G0SAE9"/>
    <dbReference type="GeneID" id="18258241"/>
    <dbReference type="KEGG" id="cthr:CTHT_0042030"/>
    <dbReference type="eggNOG" id="KOG3468">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154847_2_0_1"/>
    <dbReference type="OMA" id="YRDSCAN"/>
    <dbReference type="OrthoDB" id="268414at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008698">
        <property type="entry name" value="NDUB7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900">
        <property type="entry name" value="NADH:UBIQUINONE OXIDOREDUCTASE B18-LIKE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05676">
        <property type="entry name" value="NDUF_B7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="15 16 17" id="KW-0002">3D-structure</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="disulfide bond" evidence="15 16 17">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS19721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="7ZM7"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="7ZM8"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PDB" id="7ZMB"/>
        </source>
    </evidence>
    <sequence length="86" mass="10293" checksum="3F6AD3486C4FF2E0" modified="2011-10-19" version="1">MATDAAETSRRATREEMRDAKVPLAYRDSCAHLLIPLNRCRYETYYLPWKCEDERHSYEKCQYLEFKKRVQKMEELREAKGGARSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAH3</accession>
    <name>G0SAH3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C6 finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0042290</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694630.1">
        <property type="nucleotide sequence ID" value="XM_006694567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAH3"/>
    <dbReference type="STRING" id="759272.G0SAH3"/>
    <dbReference type="GeneID" id="18258267"/>
    <dbReference type="KEGG" id="cthr:CTHT_0042290"/>
    <dbReference type="eggNOG" id="ENOG502SKCU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011237_1_0_1"/>
    <dbReference type="OMA" id="DNGWSTI"/>
    <dbReference type="OrthoDB" id="5420905at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052973">
        <property type="entry name" value="Fungal_sec-metab_reg_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="390"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS19745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="856" mass="95022" checksum="2C0803A7FBCFE859" modified="2011-10-19" version="1">MNFDFHAPAGGETALLEQFVFDNGDRYFTTSSAAPSQDLTTTALATMSQASRQSLSPDTTWLPLDLTGNIGAPISVHSPTSSSSSSSSSGSSSGSIPSTPNEHHQNPESPVHRGSAISSPLQQQQQQQQQQQQQQQQQQQQTSPFQTTAPTPATALISDWSPLSLQQPTPDLAPFLPEHALINFAPYAVANLPPTTLDYLPATTQATLEAGLQLGPAFSPVSPVENITRVMPWATRMPGNWQDFDQLNFQADGLPRVTQTIVPHSPTGSFLSIGSSSDNGWTTIDMYSGVDAFQSSPTHSAGHSPAIFNPSQTLHIRTNSDVSDINSLDFYEDINFSSPYSPESDGFVEVSRNGADQVSPASTELVSPTATVASLPIKASATASINRPLVGSGASGSGMASPPERRNSGARKSPTIAKTTKSVIRRPSTGKKDGTGEKKVGRRRGPLLPEQRKQASEIRKLRACLRCKFLKKTCDKGEPCAGCQPSHARLWQVPCTRIDIKDIAYFMKDWKADYERHVNPSVTVYNVKGYSQKETLMWITHGYGFCLPVMVREVYVVDDSCFQVDWVESSIPNQEPIELYTRTEQLDVGQEGISRQMLNEYIDKHVDQGFEQFIDDHFEGTPFITELFKTAYRFYTKTQLPVIRTALKLVVAYNLTMHITMVEQPPTDQPMKGHIDDEDSKFYGRTVAPLLVNFQIKCAMAELWRDLQKEVLEQLSQLYSSVYSGERLKNWPTIFMLASILLAVWEEMQFDCHYRVPDPAAVEKFCRDMETVPVGVIVGLFHAISQKLPAFTEWDTRRHGQVLNNNPAVCEAMTEVRQHVLKHEAYLRTRADAKFNRLDFDSLANKFLSKLVIRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0SB26</accession>
    <name>G0SB26_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0048650</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695228.1">
        <property type="nucleotide sequence ID" value="XM_006695165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SB26"/>
    <dbReference type="STRING" id="759272.G0SB26"/>
    <dbReference type="GeneID" id="18258903"/>
    <dbReference type="KEGG" id="cthr:CTHT_0048650"/>
    <dbReference type="eggNOG" id="ENOG502S9CJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014758_0_0_1"/>
    <dbReference type="OMA" id="CRPETSF"/>
    <dbReference type="OrthoDB" id="5407653at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="580"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="622" mass="69579" checksum="F7650BD14AA08972" modified="2011-10-19" version="1">MFGSLTSMLLSHMSAAKIPRDQVPPPTPVALPRFHPQLSDEQVAQKLEGPLPAILQQIVRPNEVTLKHLEALGVHVHPDASLTELIPNPAWIPDFATWKNWTREQAIHHDEETRRRLNNGRISPGSRAYYERRNEFLLSNDDAFRTIRRLPPRKGGSVVRLGNAYEFYRNLELFTAYWDDTSKQEGDAGAAATTTAANGEDKEEEEERPGEGGFTMASFYRSHPGTKMPLDYRNNLVTAFLKLVTYDFGCNISAARYEPRLHITSRTATSSRSSYFPSGCIFIFRSPTTREDAKAGIVEGPLAAVTARNVTEFSPDADPFDKEAVVDLARELLAALITAQHRAREGREEKRFGEGAWWCTKPRWGGGPGGPIGREVDQLASGDETIGDKDAPPPVEGAHVPPPEPASAPSGPSFGRLPFGQGTSAFSRSSLRSRALGLASASGNGNGESSGGNGSDAKEIGEKASKRLKKSNPMYDNYRQIRPPSSTWDKKARYQAIGRVRGADYDDIFVVSMLFHHVSLLRVRVPNRLLEVLEGEGDDSRSWGRLEVWRSKWFDLFKPEERVEAMEAVWAMMGWLMRKEEEEEEEKEKEKEKEKEKEKEKEKEKEKEGVRQGKKDVEMSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>G0SB37</accession>
    <name>G0SB37_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitin carboxyl-terminal hydrolase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0048760</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695239.1">
        <property type="nucleotide sequence ID" value="XM_006695176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SB37"/>
    <dbReference type="STRING" id="759272.G0SB37"/>
    <dbReference type="MEROPS" id="C19.A61"/>
    <dbReference type="GeneID" id="18258914"/>
    <dbReference type="KEGG" id="cthr:CTHT_0048760"/>
    <dbReference type="eggNOG" id="KOG1867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008279_11_2_1"/>
    <dbReference type="OMA" id="NVSCNCI"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02660">
        <property type="entry name" value="Peptidase_C19D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000127">
        <property type="entry name" value="Ubiquitin C-terminal hydrolase Ubp8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000821">
        <property type="entry name" value="Ubiquitinyl hydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF937">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="1">
        <location>
            <begin position="183"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="516" mass="58663" checksum="A5162B00DD222E0D" modified="2011-10-19" version="1">MATKPAPPASPKNYKVKAPQPGTPMYGCEHLQRLFNQDQATTNTSIQHYKSILRTIFDASPVLSQTAKGIDGQAITTLTPTYLCLQCPLTLTEEDRTKHGAKKSHRFYVESRSGALYCQMCDDIVWDPTFEELRIRKMGTGTFSASRKRKHEEMFASSDPIRDNPSYITMNTTMSSCKANGLRGIYNAGATCYQNVILQCFLHNPILRNYYLSDGHPSSSCDVPHCLSCAMDDIFQSFYADESTNGYTAANILSGFWISEKKAFENLVTTKEQDAHEFFQFLAEELHERNGDGKRPEMGSEHTCNCIIHQTYYGKLQTTTTCQNCQGVTSQVQSFLDLSLPLENLAQRKKKGTAKPGPLTLQECLEEEYIKQDKCEYRCNNCGSMQQAKRQTSIRRLPNVLSIQLKRFEYKQGRNERAAKIDTPVQFPLQLNMLPYTSRARNHDVSQNYELQRSCTYDLLSVVVHVGEIDTGHYVSYCRVGDQWFVFNDHKVELAQKSDVLNSKAYLLFYCVRSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0SB50</accession>
    <name>G0SB50_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inheritance of peroxisomes protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0048900</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for peroxisome inheritance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the INP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695252.1">
        <property type="nucleotide sequence ID" value="XM_006695189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SB50"/>
    <dbReference type="STRING" id="759272.G0SB50"/>
    <dbReference type="GeneID" id="18258928"/>
    <dbReference type="KEGG" id="cthr:CTHT_0048900"/>
    <dbReference type="eggNOG" id="ENOG502S7ZC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016546_0_0_1"/>
    <dbReference type="OrthoDB" id="4097008at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005780">
        <property type="term" value="C:extrinsic component of intraperoxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045033">
        <property type="term" value="P:peroxisome inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024758">
        <property type="entry name" value="Inp1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12634">
        <property type="entry name" value="Inp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="240"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="564"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="610"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="240"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="283"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="350"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="403"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="568"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="638"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="662"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS19430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="706" mass="77092" checksum="D64117D22062F1AE" modified="2011-10-19" version="1">MDIPRPRSSGFPAPRRVVTAPVPQSTPQSPSSPQVSSGLVDTLYVHPNVKIVSFTATGRSLSVGPRTASVHEVEPGSLPWTSQLERTIAVGSFKIYRAPGSVAFLSCGSALQPILPKSQAWCVDVESSKFVLQIRRPQYWRIEVPVKEEEEVRLALQLREVFDAILLFEKTPCPFQRPFTVELPELPKTPVKKRPWTPARRSSASLPLTPVTSVEIARLHHGTPRGSFCVSDLRSKKEAAKALSEHGRRLAVPEEEETSGGDKPTSSQPIVITQPEARITKPIETSNVPREPQRNQAWLSVPLPPSPPLSSPGSPLLSRLPTTPEIPEAPTSQEETRPEAETSQASKRWSVASSDSNASSEYSVTTAPSSLPDIEVEVSSPELENTSTTNITAPTQNDEILNSIQQLTGTSTTSTREQSSSAPSTALPPTRRPVYRRATTSSSISPSRRALTPLPSAADLFVPRATLLNATSTNESLATSTALVVANRPLYTTVLHKLISSPPAHLISLMLRVASRIAAGEWRGLVLGRGEGGQEVSVHWDWSDDDDIGDDILRRGRRRRRVVWDQPETPTTPSGWQANDGTNVKDTPSKGGRTFWGDEIDDWWAQRRKEGKGKMAGTFPESDEEDDEIGPMGERRSSKSRSRSSRRGRSGSDGSRGRTRSRTNSLLLGLGLSPESDELEKRAEEAAAAANDHGYAMPGDFEWEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBE3</accession>
    <name>G0SBE3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0049960</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695345.1">
        <property type="nucleotide sequence ID" value="XM_006695282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBE3"/>
    <dbReference type="GeneID" id="18259034"/>
    <dbReference type="KEGG" id="cthr:CTHT_0049960"/>
    <dbReference type="HOGENOM" id="CLU_582658_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409435" evidence="2">
        <location>
            <begin position="28"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS19523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="469" mass="52554" checksum="FAC6E770D99C342B" modified="2011-10-19" version="1">MLLLQQTHRISLPLLLQILFFAETAYSHHNFSATPDVCGLSLHKSDYPFPFKLSFDSAHVEWSIPHLYPRLPFFGGGEMASAREQHTLIPDEDADEENGTAPLAGIAQELVMCCGDNCLQGRLSAGVWTWWSDERRRAKSELVVWWAPWHEPVRIEMPISAPDIVWIEIIRLSRKKAQVIFKKYINPYTNLTIKLLLDIATGTRQTNITGTMLINNGLRATLFYPSPHQTAAPSPSILAHFPPTSLFNNQATSNTSNEAQQAGDNSSRHSALPHTSSSSPPFPSPMPGEIPGGQICTDSIHWLLTDLTTYFPRSLQHPNSTFPGFTPVSITSHGAGFWLDISDGDVNPDDDNDSDLGEDTSSESVSNPQFPGHEHSDDEENDDHLQESEKKTNKGPIWPPVRLWHIQREIPYRGTVELCRAKAVGREEGYEEDPREEGGFGREWVLEGGHPWVWKKNVPSRVQNFSVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBI7</accession>
    <name>G0SBI7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucanase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0053720</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains.</text>
            <dbReference type="EC" id="3.2.1.91"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 7 (cellulase C) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695708.1">
        <property type="nucleotide sequence ID" value="XM_006695645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBI7"/>
    <dbReference type="SMR" id="G0SBI7"/>
    <dbReference type="STRING" id="759272.G0SBI7"/>
    <dbReference type="GeneID" id="18259410"/>
    <dbReference type="KEGG" id="cthr:CTHT_0053720"/>
    <dbReference type="eggNOG" id="ENOG502QPHV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020817_3_2_1"/>
    <dbReference type="OMA" id="DDHEANM"/>
    <dbReference type="OrthoDB" id="412382at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016162">
        <property type="term" value="F:cellulose 1,4-beta-cellobiosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07999">
        <property type="entry name" value="GH7_CBH_EG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.100.10:FF:000001">
        <property type="entry name" value="Glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.100.10">
        <property type="entry name" value="Glycoside hydrolase, family 7, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001722">
        <property type="entry name" value="Glyco_hydro_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037019">
        <property type="entry name" value="Glyco_hydro_7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753:SF2">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00840">
        <property type="entry name" value="Glyco_hydro_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00734">
        <property type="entry name" value="GLHYDRLASE7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409462" description="Glucanase" evidence="10">
        <location>
            <begin position="17"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS18763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="454" mass="49290" checksum="999712959A009BD2" modified="2011-10-19" version="1">MYRYLTTLSLVSLALGQQAGTESPERHPSLPIEVCTAPDSCVKEQTSVVLDANWRWTHIVNGYTDCYSGNSWNATACPDGKTCAANCAIDGADYEGTYGISTPSPGALRLNFVTKHQYGTNVGSRVYLLASDDKYRLFNLLNKEFTLDVDVSRLPCGINGAVYFSEMDEDGGMGRFQGNKAGAKYGTGYCDSQCPQDIKFINGEANVEGWGGTDGTSGTGKYGTCCAEMDIWEANSDATAYTPHPCKVFEQTRCEGTDCGAGSERYAGLCDKDGCDFNSFRLGNRDFYGPAKTVDTSRPFTIVTQFITDDGTDAGTLKSIHRFYVQDSKVIPNSEVVIEGVDPVNYISDSFCEQQKTAFGDNNYFKTLGGMAAMGESLKKMVLVLSIWDDHAAHMNWLDSTWPLDADPNKPGVVRGRCDPSAGVPATVEKEHPDAYVIFSNIKVGAINSTFTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBM2</accession>
    <name>G0SBM2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0054080</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695743.1">
        <property type="nucleotide sequence ID" value="XM_006695680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBM2"/>
    <dbReference type="GeneID" id="18259446"/>
    <dbReference type="KEGG" id="cthr:CTHT_0054080"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_13_6_1"/>
    <dbReference type="OMA" id="LHWICPT"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF34">
        <property type="entry name" value="PROTEIN HOL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="477"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="51"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="239"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="245"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS18798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="525" mass="57771" checksum="93A44D688101E674" modified="2011-10-19" version="1">MALQMQNSKTWKIDDNVHADDLKTADPNDPLNWPQWYKHYMATVISIAMMMCNFLAAGPFIAMVNITMDFFPGAHPAKNPRLFGSSVAKVAYFFTTTALLQGVGNFIWVPVANKYGRRPIYVLSYLIYFATAIWLSFEHSYGGFLAGRILMGFGAGAAETVAPITIADIYFLHERGTVMAFYSSFLSVGAAVGLVISGLITIHHHWRVIFQVASALIGLVHLFAIFAFPETAYTRNSSLGESKTDSSAGSGSSSDATSSSEKVEKNFALSDPKKDAEKATTSSHIPPKNTYLQTLKVFHGTFTSESLAKLVLRPLGLICLPPVLWVALVEAATIGFLVAMTSNVEVAFERTYHFESYQVGLCFVAAIIGSLVGIPVGGKFGDKVADWFTRRNEGIRNPEMRLPAMIPAMITAPLGLVLFVNFAIVQGTNIALVYVIDAYRPVAGEVTLAVMGFKSLFGFLLSFYTNTWVTQSGYLNAYGTMGAISAAVLLCWIPLYIWGKQVRHATWHWRIVRYVDWSDDREVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G0SC57</accession>
    <name>G0SC57_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0056010</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695928.1">
        <property type="nucleotide sequence ID" value="XM_006695865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SC57"/>
    <dbReference type="GeneID" id="18259639"/>
    <dbReference type="KEGG" id="cthr:CTHT_0056010"/>
    <dbReference type="eggNOG" id="ENOG502RMY0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_452693_0_0_1"/>
    <dbReference type="OMA" id="DTAIMIN"/>
    <dbReference type="OrthoDB" id="4579890at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="603" mass="66573" checksum="B18B4989C4D944F2" modified="2011-10-19" version="1">MGVITPTPKLPIRSKPLPDGHDDPSSHDEAEEILPETHISPTASSRKTKSLEVKPKSRLEEQNSESKLVGSEGNDIFDLSDITESDGSERPRKRQAQEQTNQEHSTTDKVSVRDRDGNTIATNRPRRRPKVLKDPMVLETLNQPEIKPTTNQVEPSNPKSKTDVGHRSPKMKLKAEAEWVSKKSSGVVSDFLTDLPPFALQSSEADQRRSTSAFMNQFEPLLPKQKLASSPPILHTQVHKEIITTDTGENGDHGNECSTSPLLVDQDPAHTDSKCPAVACLGNQPTHRAAAGSSAEKPDIKAAVLPSIHLDNSSNTIRRSSERLSKDPVAIKNDAVRSNAQPQDTSPLPNLKDPSATDALAPEEMWRRAIDDDSPPLVLQRLTTPKEEIVRDIAAEYEQNALRMIDNMSSRHWDEKEDMYNLLQQASRKALSIVVDAAFDIRTFTNRLQEVDLSQTTSILSKSGLADKLGVATRSFYQKVKHHTETGSIHDLMPDDFNPVSDSESQSEVLDALATTYRLRLFDAMQHSDNQDPDSAQSMVKEVNDFIEKCLAGDIKKAARPEAKQKPKPATPLTIDEELEAALNSAMVKKHHEADKLSAVGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>G0SC62</accession>
    <name>G0SC62_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0056070</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695933.1">
        <property type="nucleotide sequence ID" value="XM_006695870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SC62"/>
    <dbReference type="GeneID" id="18259645"/>
    <dbReference type="KEGG" id="cthr:CTHT_0056070"/>
    <dbReference type="HOGENOM" id="CLU_2542379_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="83" mass="8915" checksum="211C71DC6F837980" modified="2011-10-19" version="1">MSSSTSQSQNTTRNKAPNFSGGNNNDNGHANGNQGQGMTRDRARSILISDPAASRLSGHTGIDKFIRESARDAPWNPICGRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCC2</accession>
    <name>G0SCC2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0056700</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695993.1">
        <property type="nucleotide sequence ID" value="XM_006695930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCC2"/>
    <dbReference type="STRING" id="759272.G0SCC2"/>
    <dbReference type="GeneID" id="18259708"/>
    <dbReference type="KEGG" id="cthr:CTHT_0056700"/>
    <dbReference type="eggNOG" id="KOG3386">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079690_4_0_1"/>
    <dbReference type="OMA" id="DITEYCH"/>
    <dbReference type="OrthoDB" id="161814at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF115">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="133"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS19048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="162" mass="18239" checksum="9B683B3327036183" modified="2011-10-19" version="1">MDHHDHMHHMGHSSHSGMDHGSPDSAGPMCNMNMLFTWSTDNLCIVFRQWRITSTPSLLVSLALIVTICAGYEALREGIRRYDAVVARRLDTAPRQNRDAVTRRAHYIKAILYGIQNFYAFMIMLIFMTYNGWVMLAVSFGAGLGYLLFGGKTPVAKETACH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCG4</accession>
    <name>G0SCG4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Threonylcarbamoyl-AMP synthase</fullName>
            <ecNumber evidence="3">2.7.7.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">L-threonylcarbamoyladenylate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CTHT_0057130</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Likely catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. Required for normal translation, by ensuring translation fidelity at the level of codon recognition, appropriate translation initiation selection and maintenance of reading frame. Also involved in telomere replication. Binds to single-stranded telomeric (ssTG) DNA and positively regulates telomere length.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SUA5 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="3"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696035.1">
        <property type="nucleotide sequence ID" value="XM_006695972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCG4"/>
    <dbReference type="STRING" id="759272.G0SCG4"/>
    <dbReference type="GeneID" id="18259751"/>
    <dbReference type="KEGG" id="cthr:CTHT_0057130"/>
    <dbReference type="eggNOG" id="KOG3051">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031397_0_0_1"/>
    <dbReference type="OMA" id="RTQRWKS"/>
    <dbReference type="OrthoDB" id="412787at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000008">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11030">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="Sua5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038385">
        <property type="entry name" value="Sua5/YwlC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005145">
        <property type="entry name" value="Sua5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050156">
        <property type="entry name" value="TC-AMP_synthase_SUA5"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00057">
        <property type="entry name" value="L-threonylcarbamoyladenylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490:SF16">
        <property type="entry name" value="THREONYLCARBAMOYL-AMP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03481">
        <property type="entry name" value="Sua5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="YrdC-like" evidence="15">
        <location>
            <begin position="94"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="38"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGS19090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="470" mass="49848" checksum="A1B73215A81CF115" modified="2011-10-19" version="1">MTTNSTTPSTTTNPPSPTTTTIIETRILKVPLPNLASLNADDSPLGRWRRKSDGSRDLSVWEVPSSPSSSNPSPSVTTAANGNRKSIRNEGDVLAPIREAAHALLTTPIPVAFPTETVYGLGADATRSDAVRGIYAAKGRPSDNPLIVHVCDLTMLRRLLKPDWTEEDPDPIPPIYHPLISKFWPGPLTILLPLPEPSPLAPEVTAHLSTFGARLPASPLARSLIALTNRPLAAPSANASTRPSPTTAQHVRDDLDGRISLVLDGGPCDVGVESTVVDGLSTPPAVLRPGGVGVEEIRGVGKGWERVVLAWGEVVKGVPRAPGMKYKHYSPKARVVLFERGAAQGTKGRMIEEEVGKLREEKTVGIIRTGGWEFAGGSLQVSGERREVIGEGGVVVVEGKTIVPGKEVKLLDVDLGQDVKGVAHGLFAALRALDGLGADVIYVEGVEDRGEDLAAAVMNRLRKAASEIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCQ8</accession>
    <name>G0SCQ8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0058090</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696129.1">
        <property type="nucleotide sequence ID" value="XM_006696066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCQ8"/>
    <dbReference type="STRING" id="759272.G0SCQ8"/>
    <dbReference type="GeneID" id="18259847"/>
    <dbReference type="KEGG" id="cthr:CTHT_0058090"/>
    <dbReference type="eggNOG" id="KOG0236">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003182_0_2_1"/>
    <dbReference type="OMA" id="GMIMFPI"/>
    <dbReference type="OrthoDB" id="409725at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034490">
        <property type="term" value="P:basic amino acid transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.24:FF:000012">
        <property type="entry name" value="Sulfate transporter family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052706">
        <property type="entry name" value="Membrane-Transporter-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43310:SF4">
        <property type="entry name" value="AFR304WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43310">
        <property type="entry name" value="SULFATE TRANSPORTER YBAR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="457"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="543"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="625"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="651"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="682"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="11">
        <location>
            <begin position="753"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="980"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="38"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="890"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="898"/>
            <end position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS19184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1060" mass="116799" checksum="334B8276962EA07C" modified="2011-10-19" version="1">MMGGSSPHLSVLGNLPPIDSAESARCVREDTAELAHYILSDKDSRGSPFLRRQRSVSSQPTRQRTISSTPNLGDMHGPVAAGASSPIAESSEPPSPWGSFVAEGRRASTAGAATSSNPSMLTTMFKKSPPPRPDVRSYFPAPPPRDDQVFEENLPPTDDDDVPSETGSQETLTRVSTVEHRPLFGDRDAREAEEEAAGETSPLLAFRSRESRGSSSYGSGNGLANGHNGAGLIDLEGQKHARRRGWFGRTWDSLVETKDRVKEVVPVVVNPKRWNRYAMWESIVVAPMACLPAVVVGLLLNILDALSYGMILFPLGRPIFANLGSVGISMFYVSCIISQLTFSFGSIFKGGVGSELIEVVPFFHNMAATITDIVGEDDPEAVIATTISSYALSCMLTGAVFFLMGKFKVGYLVGFIPRHILIGCIGGVGYFLIATGFEVTARLDGNLEYNLETLKRLLQANTVPLWIIPLVLAVILFYGQSKITSKYFLPLYILAIPAAFYAVAAAMDVLDPETLRDGGWVFQGPPAGEPWWHFYTLYKFHKIHWGAIVHCIPAMFALTFFGILHVPINVPALALNTGEDHADLNHELKLHGYSNLFSGMAGSIQNYLVYSNSLFFMRSGGDTRLAGFELALFTFLVMIMGPGMIGYIPVMMVGVLIFDLGFELLLEAVWQPRKKLKTAEYLTVIVIVLVMGTYDFVVGIGVGILLAFVSLIFQTSRISAVRASYSGDVVGSTVRRNPTQQHYLRQVGRQINILKLSGYLFFGTIVGVEDKIRALITEEAFNRHPIKFLILDLWLVTGLDYSAAEVFNTISRLCNSKDIELVISGVDAERGLGRNLRAVGLGEDGIEVKLLPDLNSALEYCENELLKTLYANLDDDTASTRSTSTVISGANHLDVPDTQHSSDTNNNNTMLGTSPRRVLLREAARASLHHSLEAIQHQYSRSSLSKWQSFSEPLRLMLQIFRDVSDKNEDFWFRAVPYFKRYEHSPGTVLFRRGEPADGFYLVEAGILRAEYDLPQGMLFESIVAGTTTQNMEIDVISMYETQWLSMPVLPFEVQDAFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0SD49</accession>
    <name>G0SD49_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0050810</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695424.1">
        <property type="nucleotide sequence ID" value="XM_006695361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SD49"/>
    <dbReference type="STRING" id="759272.G0SD49"/>
    <dbReference type="GeneID" id="18259119"/>
    <dbReference type="KEGG" id="cthr:CTHT_0050810"/>
    <dbReference type="eggNOG" id="KOG4231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_144_6_1"/>
    <dbReference type="OMA" id="PEFDCTI"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07216">
        <property type="entry name" value="Pat17_PNPLA8_PNPLA9_like3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF4">
        <property type="entry name" value="SERINE HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G07870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="4">
        <location>
            <begin position="20"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="133"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="454"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="24"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="272"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="486"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="512"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="584"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="621"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS18479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="653" mass="72051" checksum="5D7B0C5DE30A8165" modified="2011-10-19" version="1">MDSQGLRRRDTTKGPPLRILSLDGGGVRGYSMFILLQQIMHQTFVEIEGRAPRRHEIPKPCDHFDLIVGTGTGGLIALMLGRLRLDLETCKELYVRLTRMVFETDKTIAGIPYRSTLFKATKLEEAIKEAVREHTVNETEGNDGSTIFSPLSPVSRSSAARPRRHSSNASVISFSSRSPQSQNTRPPPYTWRLGDPEARLYDEREYRTKTAVTAIYKGTPKGGAPALLRSYDSRREPAPEFDCKIWEAGRATCAIGLAFKPIQIGQSVFHDDGAGDFNPSMIALDEAVVNEWPGREVGVFISLGTGKRPRGSDANSALWYEGFLGEFAEARRKLIAKIEGCEKIHEKMKKEHLARRGVNPENYYRFNVEVGVGEFGMNEWNRLADISTNTKHYLSRDEENRMVQSAAAKLAKIHFARLRRERAENATVPASAPNAVQPYVPVSDIEIPMIAELPGDFPTIAPPRPSTPPSRQSFDSGTDSLPVRTHTPSPRTSAERPQQSPNLSAQPFQLAAPPPPSSMPMPGSPSQAPPTRPPKQVGPGVPGLPSSDDSDRLVVNAPTPSQYRLASSVEKITVVGPDDWPYWPQEPPAQAPPFLEPPPRPPKTPLPEHQQGPGRKMTAPVPAPAPLPPYPLDDDEQPPPMVNMARKPRYTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0SD75</accession>
    <name>G0SD75_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0059210</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696240.1">
        <property type="nucleotide sequence ID" value="XM_006696177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SD75"/>
    <dbReference type="STRING" id="759272.G0SD75"/>
    <dbReference type="GeneID" id="18259959"/>
    <dbReference type="KEGG" id="cthr:CTHT_0059210"/>
    <dbReference type="eggNOG" id="KOG1212">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_9_3_1"/>
    <dbReference type="OMA" id="GMQPWKY"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1300.10:FF:000003">
        <property type="entry name" value="Amidase signature enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF10">
        <property type="entry name" value="ACETAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="66"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="213"/>
            <end position="216"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS19295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="561" mass="62076" checksum="C1B89A55F23317BD" modified="2011-10-19" version="1">MSILISYLHHRRDCRLKQSQRSSTISSLPAIYHTPLSDSDKSIITSPIASLVAGIHAGTTSPLSVLHAYGKLAVKAHARTNCLTEVMISDAEKWAEGDREKGGVNLKGPLAGIPVSLKDTIVVGGYDTTVGYSSFVGNKTTQDGAIVRLLKDLGAVPYVKTNLPITLLSFESTNAVWGRCVNPHNPAYSPGGSTGGEAALLAMGGRIGVGSDVAGSVRLPAHWSGCYSLRCSTGRWPKAGICTSMPGQEGVPSVYSPMARTLDDLRYFVRAVLDEGTQVWRYDHSVHPLPWRDSFEKDVLQERRRLKVGVLRTDGVVDPSPACVRALGMVEEALKREGCEVVTVEGAPDMYEGLRLASLLLNADGCQMFESFRRWGEWNDPGARQMRRLASLWAPLRYIYYLWVRYVRSDQVWAGLVRHWSPKSAFENWKLVMQREAYRAKWFEYWNSQGFDAIIAPPNATPALPHDAMKDALDYSAGVLPVTRVDKELDALPASFKLRNLNGVAQGAYKHYKADRMHGLPVGVQVVCRRLEEEKVLAVMQRIEDGLGEEKYKLMSLDELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0SD99</accession>
    <name>G0SD99_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0051020</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695445.1">
        <property type="nucleotide sequence ID" value="XM_006695382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SD99"/>
    <dbReference type="STRING" id="759272.G0SD99"/>
    <dbReference type="GeneID" id="18259140"/>
    <dbReference type="KEGG" id="cthr:CTHT_0051020"/>
    <dbReference type="eggNOG" id="ENOG502TKFQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036218_0_0_1"/>
    <dbReference type="OMA" id="MQQRHAS"/>
    <dbReference type="OrthoDB" id="3757673at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS18500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="278" mass="30868" checksum="E8DA04F597D6A879" modified="2011-10-19" version="1">MTSNIFPHSQPSVLTPSPPTAPISAPLPLAVLLSLTSFLLLVTLLVHILPYYKSYLSASSEVSCLLETSDYLLAEADTYTHEVSKLPRLSDRVRLSKLVREFRREAEALRKEVNSLVLRRGQHQEHGRGEGLALRPIARLGWAVYKGRLDERIRRVDVLRVRLLVAQVGVISNTIAESTPPPTRENSPGLGVIYEEKPLDAPPTPPLTPKTMPRKGWDSSESFNTTELTPAKQKLTLQTDCVDTSSRKGWAGVVRELQKSPLLKERHASIELAMSRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDN3</accession>
    <name>G0SDN3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Glutamate--cysteine ligase</fullName>
            <ecNumber evidence="3 11">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Gamma-ECS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Gamma-glutamylcysteine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0052390</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cysteine + L-glutamate + ATP = gamma-L-glutamyl-L-cysteine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glutamate--cysteine ligase type 3 family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="3 11"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695579.1">
        <property type="nucleotide sequence ID" value="XM_006695516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDN3"/>
    <dbReference type="STRING" id="759272.G0SDN3"/>
    <dbReference type="GeneID" id="18259277"/>
    <dbReference type="KEGG" id="cthr:CTHT_0052390"/>
    <dbReference type="eggNOG" id="KOG3754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010467_0_0_1"/>
    <dbReference type="OMA" id="IAHMFIR"/>
    <dbReference type="OrthoDB" id="7939818at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000001">
        <property type="entry name" value="Glutamate-cysteine ligase Gcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000004">
        <property type="entry name" value="Glutamate-cysteine ligase Gcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004308">
        <property type="entry name" value="GCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164:SF0">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03074">
        <property type="entry name" value="GCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="5 11 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="487"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="538"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="544"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS18634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="723" mass="82320" checksum="9A0BEE6A9764ED01" modified="2011-10-19" version="1">MGLLALGTALDWPDAKKQANLVRSWGIKVRSDFMLSLLPSVKAGKANDAMEIRLTPFPQQLLEIWNKAKGKERDAMLWGDEVEYLVVVYSKESPKVLLSLRQADILKALENIKDVPEKAADGQSTRSPPVFHPEFGRFMLEATPGKPWGIEFRELLEVEPNMKARRRIAKAHMLPNEYPITLTTFPRLGVPGVFTEPFYPVSGPKLRSQFVPDEIANPHIRFPTLAANIRARRGRKVQVNVPVFRDEKTPWPWKDPTVNYDLHNWPEDDDVRNGAAPDNYIHMDAMAFGMGSCCLQITFQAKNITEGRQMYDQLSPLGPIMLALTAATPIYKGFLADTDVRWNQISKAVDDRTPEELGEKPLKNDRWRIPKSRYASNSTYISEDPRLRPEYLDPDLVIDESIKQQLLDGGMDDRLATHFAHLFIRDPIVIFSEDLQELDLTKTDHFENIQSTNWQHMRFKPPPADNNIGWRVEFRPMEIQITDFENAAFAVFIVLVTRVILSFGLNFYIPIRKVDENMETAHARDAVLTRRFHFRRNLFPPSRPSRSASSRSGSGTSTPMSTSSGSSTPAAPVESEYRLMTINEIINGTAYARANSQYQRQQPDLQQDDYDHSDYLEEEDFPGLIPLVESYLDSVNVDVTTRCQLARYLDLIRKRASGELWTAAHWIREFVARHPRYEKDSVVGEEIAKDLVGAVVAIGEGKGESVWGVDKFLGRFVPKDPIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDZ1</accession>
    <name>G0SDZ1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Short-chain dehydrogenase/reductase 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Retinal short-chain dehydrogenase/reductase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0053510</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695687.1">
        <property type="nucleotide sequence ID" value="XM_006695624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDZ1"/>
    <dbReference type="GeneID" id="18259389"/>
    <dbReference type="KEGG" id="cthr:CTHT_0053510"/>
    <dbReference type="eggNOG" id="KOG1201">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_5_0_1"/>
    <dbReference type="OMA" id="HYWLAQE"/>
    <dbReference type="OrthoDB" id="10253736at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052650">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000131">
        <property type="entry name" value="Short-chain dehydrogenase/reductase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS18742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="378" mass="42106" checksum="4F8FD9DECC428F8E" modified="2011-10-19" version="1">MPMHNAFLPREGFKADAVLKIIRNTALNPKLLLPLLLLVKYTKKGQDWAVLHPKAYSRLKKLLVFSLIRCINRYFSRGVLNNWVDDKYDWSKEIVVITGGAGGIGGQVVQLLAERGIKVVVLDIQPLTYPAGPTVYYFKCDITSPKTLAAVAGEIRATVGEPTILVNNAGVVQGRTILDASERDIRFTFDVNTFAHYWTVKEFLPSMIRNNHGMVVTVASVAAWVTVPNMVDYAASKAAAHAFHDGLTAELKTRYNAPKVRTVLVNQGYTTTPLFKGYYNDSPFLMPALHPETVAEAIVMQILKGESNQLVLPAFANTLSMLAALPHWYQVRLREKNHRIMAQFAGRKVVQDLDKFYEEREKVEAAGDFGASTVLVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0SE14</accession>
    <name>G0SE14_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative translation release factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0062060</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696522.1">
        <property type="nucleotide sequence ID" value="XM_006696459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SE14"/>
    <dbReference type="STRING" id="759272.G0SE14"/>
    <dbReference type="GeneID" id="18260244"/>
    <dbReference type="KEGG" id="cthr:CTHT_0062060"/>
    <dbReference type="eggNOG" id="KOG2726">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089470_1_0_1"/>
    <dbReference type="OMA" id="RIMLCEY"/>
    <dbReference type="OrthoDB" id="277888at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000065">
        <property type="entry name" value="Peptidyl-tRNA hydrolase domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052405">
        <property type="entry name" value="Mito_Transl_Release_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203:SF1">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION RELEASE FACTOR IN RESCUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203">
        <property type="entry name" value="PROBABLE PEPTIDE CHAIN RELEASE FACTOR C12ORF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="6">
        <location>
            <begin position="85"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="66"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="165"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="165"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS18191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="231" mass="25378" checksum="3D0F65C2059016FA" modified="2011-10-19" version="1">MTPATTPLLRRALVAFPAANAISHGLRSPKNDSILLPSVRGPSLLGTLSPTVTLLGRSVPATAAPFTTSPLLHKKPLPPRPKPPPESEIEESFLKGSGPGGQKINKTNSAVQLRHTPTGIVVKCQATRSREQNRKIARELLAQKLDELINGDKSRTAIVSEIKRKKAASRAKKARRKYRKLEEAKKQAARLEEGGNEGKEFEEEEEEEEEGEKDEDELDTNTQDNIKEKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G0SE38</accession>
    <name>G0SE38_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0062300</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696546.1">
        <property type="nucleotide sequence ID" value="XM_006696483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SE38"/>
    <dbReference type="STRING" id="759272.G0SE38"/>
    <dbReference type="GeneID" id="18260268"/>
    <dbReference type="KEGG" id="cthr:CTHT_0062300"/>
    <dbReference type="eggNOG" id="KOG3290">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048953_0_1_1"/>
    <dbReference type="OMA" id="KYSEDNW"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF15">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS18215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="322" mass="35739" checksum="4ED656C8A3C60850" modified="2011-10-19" version="1">MSSDGLTPEQLAAFHRDGYLIIPDALPPTTVTALLDETHRLLDSLDLSTHPLTRFRTGGETGEDHVGDDYFLTSGDKIRFFFEEDAFDSEGNLVRPKHRAINKIGHYLHGLSAPFKALLARGPEDEGWDLAKDMKARPATVARQLGYVDPRCLQSMIICKQPEIGGAVPAHQDSTFLYTDPPSAVGFWYALEDATLENGCLSFLPGSHRWAPVEKRLVRNGDGSDGKGTKMVVNEGSRFPRGEGYGEELRGQAREGEYVPGEVKAGSLVLIHGNLLHKSERNTSQKGRIIYTFHVIEGAEGWRYDEKNWLQPPTEGFTKLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G0SE39</accession>
    <name>G0SE39_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0062310</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696547.1">
        <property type="nucleotide sequence ID" value="XM_006696484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SE39"/>
    <dbReference type="STRING" id="759272.G0SE39"/>
    <dbReference type="GeneID" id="18260269"/>
    <dbReference type="KEGG" id="cthr:CTHT_0062310"/>
    <dbReference type="eggNOG" id="ENOG502S8AT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041452_0_0_1"/>
    <dbReference type="OMA" id="YLPDMFL"/>
    <dbReference type="OrthoDB" id="4034134at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038872">
        <property type="entry name" value="Put_GTT3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41807">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41807:SF1">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS18216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="401" mass="42619" checksum="116CEA7390B77BF1" modified="2011-10-19" version="1">MANPWLARQRKAELVELAQAVGLKDVDSKRKADLEIAIDEVLSDNAARYQSDPRFTDYFKSRARAGGSPVKRERESAAATGAAAGDVKPSRRKSTKPIEEPVAATESEESESPTDPSAAPSDTPSMALTRTPARAFALAARLTNSLPATPADVAQAVDRSTVAVRSQLSSLVGPASPVATSLTDAAHTTRAWLSTVHAVLSAAALFEAYHLRRELLPDVYAFTIPAISWLGTGDKPVHVPDVFALLTSGFWACTATWLLTSLIIPGVAGWFFNLSSATGTAPVRVPASAPAKRSRGRPSGASQKREGVDKNQEEEQEEEGGEGMSEGKQQKQEYAVDPLMFSVAKALITYVVYAQGVTFGGLLSPWAVTRVEAALYSGWRGVLVGTGVTALAAVWEAVSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G0SE57</accession>
    <name>G0SE57_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0062520</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696565.1">
        <property type="nucleotide sequence ID" value="XM_006696502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SE57"/>
    <dbReference type="STRING" id="759272.G0SE57"/>
    <dbReference type="MEROPS" id="M01.034"/>
    <dbReference type="GeneID" id="18260290"/>
    <dbReference type="KEGG" id="cthr:CTHT_0062520"/>
    <dbReference type="eggNOG" id="KOG1047">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014505_1_1_1"/>
    <dbReference type="OMA" id="CTALQWM"/>
    <dbReference type="OrthoDB" id="79562at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09599">
        <property type="entry name" value="M1_LTA4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000009">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.320:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000004">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.30:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.320">
        <property type="entry name" value="Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049980">
        <property type="entry name" value="LTA4H_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038502">
        <property type="entry name" value="M1_LTA-4_hydro/amino_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034015">
        <property type="entry name" value="M1_LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015211">
        <property type="entry name" value="Peptidase_M1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726:SF3">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09127">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01263">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal" evidence="14">
        <location>
            <begin position="466"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="135"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="265"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="563"/>
            <end position="565"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR634015-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR634015-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR634015-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS18234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="612" mass="69542" checksum="2FA83947B94DB8D8" modified="2011-10-19" version="1">MAPVRDPNTLSNYHEWRTKHTIANFTVDFAKQCLRGSVILELESQTDKASKEIILDSSYLDLAGIKLGSTPAQWEVKERAGPNGSPVHISVPEGADKGETVTLEIDVATTDKCTALQWLTPAQTSNKKAPFMFSQCQAIHARSIFPCQDTPDVKSTYEFNIRSPHVVVASGVPVPEATKDVDGEKVYKFVQKVPIPSYLFALASGDIAMAPIGKRSVVATGPNELEASQWELEEDMDKFLDAAERIVFPYQWGEYNVLILPPSFPYGGMENPIFTFATPTIISGDRQNIDVIAHELAHSWSGNLVTSCSWEHFWLNEGWTMYLERRILAAIHKNDAYFDFSAIIGWKHLEEAIEEFGKDHEFTKLCISHKGIDPDDAFSTVPYEKGFHFIYYLDRLVGRENFDKFIPYYFKKWSNKSLDSYDFRDTFLEFFSAPEYADLKDKISGIDWEGRFYNTGLPPKPEFNTSLVDVCFELANKWKRRDFEPSPSDTASFTSNQVLVFLNAIQNFEEPLTVEQSQILGKVYGLTESKNVELKTAYFQIAMRAKDTSAYPAVAELLGKVGRMKFVRPLYRSLSKVDYDLAAKTFEKNRDFYHPICRQLVEKDLGLAEKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0SE63</accession>
    <name>G0SE63_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Guanine nucleotide-binding protein alpha-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0062580</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-alpha family. G(q) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696571.1">
        <property type="nucleotide sequence ID" value="XM_006696508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SE63"/>
    <dbReference type="STRING" id="759272.G0SE63"/>
    <dbReference type="GeneID" id="18260296"/>
    <dbReference type="KEGG" id="cthr:CTHT_0062580"/>
    <dbReference type="eggNOG" id="KOG0082">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014184_6_0_1"/>
    <dbReference type="OMA" id="ANSHWFK"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000051">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF242">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-1 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="45"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="148"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="173"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="242"/>
            <end position="245"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS18240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="327" mass="38100" checksum="9AE4F628C9DE20E6" modified="2011-10-19" version="1">MCFGGREKRVDEVGAARSRDIDKMIKADEKRMQREMKFLLLGAGESGKSTVLKQMKLIYAQGFSKHEKMEWKPVKHMAQIMIDYEMTADEPLPIEYYEPLKSLWVDAGVKKAIEKGNEYALHDNLDYFCDDLDRLWDRNYVPTDQDLLRSRLRTTGITETVFDLGQLTYRMLDVGGQRSERKKWIHCFENVNCLLFLVAISGYDQCLVEDKDGNQMNEALMLWESIANSHWFAKSALILFLNKIDLFREKLPRSPITAHGFTDYHGPPDDDKQASKYFMDKFRALNRNPDKEIYGHFTNATDTNLLKITMNSVQDMIIQRNLKQLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEJ5</accession>
    <name>G0SEJ5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mannose-1-phosphate guanyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GDP-mannose pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">GTP-mannose-1-phosphate guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0063970</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>alpha-D-mannose 1-phosphate + GTP + H(+) = GDP-alpha-D-mannose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="EC" id="2.7.7.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="3"/>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696703.1">
        <property type="nucleotide sequence ID" value="XM_006696640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEJ5"/>
    <dbReference type="STRING" id="759272.G0SEJ5"/>
    <dbReference type="GeneID" id="18260435"/>
    <dbReference type="KEGG" id="cthr:CTHT_0063970"/>
    <dbReference type="eggNOG" id="KOG1460">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_3_0_1"/>
    <dbReference type="OMA" id="MPVPNWW"/>
    <dbReference type="OrthoDB" id="285674at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06428">
        <property type="entry name" value="M1P_guanylylT_A_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="10">
        <location>
            <begin position="311"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS18372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="441" mass="49013" checksum="4E911959FFEDBF95" modified="2011-10-19" version="1">MSLQLPLRERSNGIPGVTKAVILVGGASRGTRFRPLSLDVPKPLFDIAGHPIIWHCLAAISKVPSIHEVYLIGYYEESVFRDFIKDASLEFPNLSIKYLREYQALGTAGGLYHFRDTILRHHPEHIFVLNSDVCCSFPLNEMLRLAEEKDAEAVILGTRVPEEAACNFGCIVSDSHTRRVLHYVEKPESYISNLINCGVYLFSADALFPSIRSAIKRRVDRPRLASYRSSENLAASFHLEDDDSTEKPEVIRLEQDILSDMADNKQFFVYETKDFWRQIKTAGSAIPANALYLQKAWQNGSQELAQPSANIIPPVYIHPTAQVHPTAKLGPNVSVGPRAVIGAGARVKESIVLEDAEIKHDACVLYSIIGWSSRVGAWARVEGTPTPVTSHNTTIIKNGVKVQAITILGKECVVGDEVRVQNCVCLPFKELKRDVANEVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFB7</accession>
    <name>G0SFB7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0061480</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696464.1">
        <property type="nucleotide sequence ID" value="XM_006696401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFB7"/>
    <dbReference type="GeneID" id="18260186"/>
    <dbReference type="KEGG" id="cthr:CTHT_0061480"/>
    <dbReference type="eggNOG" id="ENOG502RS71">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_356010_0_0_1"/>
    <dbReference type="OrthoDB" id="5413827at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="788" mass="87912" checksum="06D0E73358779E8E" modified="2011-10-19" version="1">MSVQIKPFLNRTVEPDRRRSTAEVEAATPYSYSIQARPVYSTYFTFAAHPGCPEYSTSSSVRESLAAASTKMSTDSHFYSYHAARNTLTFGRNLYDEYITRQNTAQQKVTQNFNRDFVSVGARPRSIISPATSSITHSNVVGQSAYASNIGQEHRLGQAPVAPASPSSGHAAAQKLPKKGVLGQRDERISDTITVRRPAASSSVPRTKAVVQQVPKKRTTAQRDEYNEDIIVVRDPVARASPRVPRRQGPPTTADIIDLTADEELPTGTTFSHDSNDEDVIELEPPAAEYHKGLRAFLHKPPRQVVTNSRPRKRQRQVQAVSQAAKTRAQLHNPRASAQARITRARNYPDALSARLHENLPVPDRDMALPERPQPSAVQKNNTSHNQNLRPRRKAADIAESEIMVATSSILPSVESSTGFFSLAPEIRDKIYRHLLVSSTPVGVRNLWTELARRTRRRRGNCDSGTRGNDSIININILLVCRQTAAEGIRVLYSENTFLYQLRDPEVVCRLQQEHRLVLRTAPRGFPETGINLEKYAHLLRHITIELEPNRSGTAYEKLMAAAIQALALPHIRLYKLTITVSPLFETYRRKAGGSGTVKTKYLSVVPYFSKNAPVLKALLGVNTRFLRINVHTNSKQNNSTLGRRRAPTPIIITTASAANNNNAGVDSSSDSDSGNNIFQSSAAAYKKTSDTTSRHYEATLDLRYVPWNEVNTPVKRQLSPSPLPDQLEHDELAQAKRRERGQVAKQALLSLRRHIEEACTLSPAELKCVENNIWEEHAEAEKKRKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFG9</accession>
    <name>G0SFG9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable enoyl-CoA hydratase, mitochondrial</fullName>
            <ecNumber evidence="2">4.2.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0070770</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="2"/>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697352.1">
        <property type="nucleotide sequence ID" value="XM_006697289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFG9"/>
    <dbReference type="STRING" id="759272.G0SFG9"/>
    <dbReference type="GeneID" id="18261115"/>
    <dbReference type="KEGG" id="cthr:CTHT_0070770"/>
    <dbReference type="eggNOG" id="KOG1680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_6_1"/>
    <dbReference type="OMA" id="FCDARED"/>
    <dbReference type="OrthoDB" id="2018133at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000019">
        <property type="entry name" value="Enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000001">
        <property type="entry name" value="Probable enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF54">
        <property type="entry name" value="ENOYL-COA HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS17734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="292" mass="31206" checksum="5A6FF46D5879AF21" modified="2011-10-19" version="1">MSARLFGSVRVASRFQPSALPRVARSFSTSACRSYEFIEVSEPRPGVGLVKLNRPKALNALCSPLIDELNTALRAFQASPTVAAVVLTGSERAFAAGADIKEMAPLTFSEAYTKSFIESWSDLTTALKKPLIAAVAGHALGGGCELALMADILYCTANANFGQPEIKLGVIPGAGGTQRLTRAVGKARAMDLILTGRSFSGEDAERWGVAAKVFPDYEALLEGALSTAETIAGYSKVAVQAAKEAVNKSQDLALRDGVEYERRVFHSLFGTNDQKIGMKAFAEKKKPEWTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFL8</accession>
    <name>G0SFL8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0071310</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697401.1">
        <property type="nucleotide sequence ID" value="XM_006697338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFL8"/>
    <dbReference type="GeneID" id="18261169"/>
    <dbReference type="KEGG" id="cthr:CTHT_0071310"/>
    <dbReference type="eggNOG" id="KOG1944">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066033_0_0_1"/>
    <dbReference type="OrthoDB" id="860at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF93">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN 25D9-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="307"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="312"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS17783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="39306" checksum="1D4F9B540B514FFB" modified="2011-10-19" version="1">MSPKVDIDVSDMVEDAVKDVVKHAVKEQLKDAKEVIKHPFKEAKEAITHPFKEAKEVITHPFKEAVQDIREFKAEVKKDGGFIGHTAAAIHEAATGQLPGTSGKHPISAVVGTALTGGRKNAGTRGYLADHPLRTKMLTAGTLAGGQELLASWLAKDRNKHGNYFTSRVPKMAAYGAFVSAPLGHFMIWCLHKAFSKRTSLRAKIMQILVSNFIIAPIQNTVYLVAMALIAGARTWQQIRATVRVGFWKVMRVSWISSPICLAFAQKFLPQDAWVPFFNLVSFIIGTYINTITKKKRLAALRKKHFGDRATAPPPPPPGPAGPGPNLGMGGPRPEDYPHPHPHPHPHPHTGLGPNPPYQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-03-16" modified="2025-04-09" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFM2</accession>
    <name>DBP2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName>ATP-dependent RNA helicase DBP2</fullName>
            <ecNumber>3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>DEAD box protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">DBP2</name>
        <name type="ORF">CTHT_0071350</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-dependent RNA helicase involved nonsense-mediated mRNA decay and ribosome biogenesis through rRNA processing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="6">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EGS17787" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="3.6.4.13"/>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17787.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697405.1">
        <property type="nucleotide sequence ID" value="XM_006697342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFM2"/>
    <dbReference type="SMR" id="G0SFM2"/>
    <dbReference type="STRING" id="759272.G0SFM2"/>
    <dbReference type="GeneID" id="18261173"/>
    <dbReference type="KEGG" id="cthr:CTHT_0071350"/>
    <dbReference type="HOGENOM" id="CLU_003041_16_9_1"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17966">
        <property type="entry name" value="DEADc_DDX5_DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000435812" description="ATP-dependent RNA helicase DBP2">
        <location>
            <begin position="1"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="160"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="347"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="534"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="4">
        <location>
            <begin position="129"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DEAD box" evidence="2">
        <location>
            <begin position="283"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="173"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P24783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="556" mass="60625" checksum="D008464162849C27" modified="2016-03-16" version="2">MSSYGGGYSGGGGGYSNNYDRNGGYSNGYSGSNGYSGGGGGYGSHGSRSYGGGGYGGGYGGGDRGGDRMAGLGSGLQKPNWDLATLPKFEKSFYKEHPNVTARSMAEVEKFRRDHNITVSGRDVPKPVETFDEAGFPRYVMDEVKAQGFPAPTAIQAQGWPMALSGRDVVGIAETGSGKTLTYCLPAIVHINAQPLLAPGDGPIVLVLAPTRELAVQIQQEINKFGKSSRIRNTCIYGGVPKGPQIRDLQRGVEVCIATPGRLIDMLESGKTNLRRVTYLVLDEADRMLDMGFEPQIRKIISQIRPDRQTLMWSATWPKEVRNLAADFLTDFIQVNIGSLDLAANHRITQIVEVISESEKRDRLIKHLEKIMDSRDTQNKCLIFVGTKRVADDITRFLRQDGWPALSIHGDKQQNERDWVLDQFKTGKSPIMVATDVASRGIDVRNITHVINYDYPNNSEDYIHRIGRTGRAGAKGTAITFFTTENAKQARDLVSVLQEAKQHVDPRLLEMARYSGGGGSSRYGGYRGRGGGGYRGGHRSAAHSGANAVPVANRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFZ5</accession>
    <name>G0SFZ5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0072700</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697528.1">
        <property type="nucleotide sequence ID" value="XM_006697465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFZ5"/>
    <dbReference type="SMR" id="G0SFZ5"/>
    <dbReference type="STRING" id="759272.G0SFZ5"/>
    <dbReference type="GeneID" id="18261308"/>
    <dbReference type="KEGG" id="cthr:CTHT_0072700"/>
    <dbReference type="eggNOG" id="ENOG502SJ3M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_0_1_1"/>
    <dbReference type="OMA" id="GICECVG"/>
    <dbReference type="OrthoDB" id="9996127at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF9">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409200" description="FAD-binding PCMH-type domain-containing protein" evidence="6">
        <location>
            <begin position="19"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="65"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS17910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="478" mass="53433" checksum="E9C23A9F18E1A9D9" modified="2011-10-19" version="1">MKLIHTLLDLLTPITVIAHKGDHTPKTIDFASLSLLLSPSSSITFPKASSLNPLLRWSFNINVNYPALPRAVVSPATEADVVATIKFSNKHEIPFLVQGGGHATSASLKEFKEGVLISMKKFDKLEIKPGRKTALIGVGLKVNDVVHGLWKEGLQTTTGICACAGAVGPALGGGHGFLQGQYGLAADEIVRNEDLFWAIRGAGHNFGVITEMEYKVHEVEEGKKTWAVQAFVFTGSVEHVEELYKVAEELRKKQPKEMVPIIAFQFMYNGPQSDFVAYTKPLADFTPIATFSNVTDYPGLMTFIGTHLEGPLCPEKSTAVLHAADVDYYDVPAIRNVWELFNEMVTTVPGLAGSYMMLEGYSVQAMQAVPEESTAYPHRKQDFLLAPILLWVNGNKTLDELGEKWGIKLKQASWSKFRPRSYINYAAVDESLETLYGEQWRLKKLRRIKETYDPENHFRFFSPIIRREKPEKTRKEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0SG16</accession>
    <name>G0SG16_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-xylosidase C-terminal Concanavalin A-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0064690</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696773.1">
        <property type="nucleotide sequence ID" value="XM_006696710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SG16"/>
    <dbReference type="STRING" id="759272.G0SG16"/>
    <dbReference type="GeneID" id="18260507"/>
    <dbReference type="KEGG" id="cthr:CTHT_0064690"/>
    <dbReference type="eggNOG" id="ENOG502SM8A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016508_2_1_1"/>
    <dbReference type="OMA" id="KLTEAPH"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09000">
        <property type="entry name" value="GH43_SXA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF12">
        <property type="entry name" value="BETA-XYLOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-xylosidase C-terminal Concanavalin A-like" evidence="7">
        <location>
            <begin position="329"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS17155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="541" mass="61685" checksum="60BB6E7725D99C45" modified="2011-10-19" version="1">MPPVRNPILPGFNPDPSVLRVGEDYYIATSTFEWYPGVQIHHSRDLANWEVIVRPLSRKSQLDMRGNPDSCGIWAPCLSHDGEKFWLVYTDVKRKDGSFKDTPNYVVTARDITGPWSDPIFLNSSGFDPSLFHDLDTGKKWLVNMLWDHRQRPHYFAGIALQEFDPIQGKVVGPRKTIFYGTDLALVEGPHLYKRNGWYYLLTAEGGTGYDHACTLARSRDIWGPYEVHPQKHILTSKDHPRSALQRAGHGDIVDTPDGRTYLVHLTGRPVTQRRRCVLGRETAIQECYWAEDGWLYVKDGPVPSLWVDLPAARDEAKYWAEKIYTFETGLPKDFQWLRTPEPERIFETNPEGKLVLTGRESIGSWFEQALVARRIEHFSLDAETVIDFSPTDERQFAGLTVYYCRYNFFYLTITAHSNGQRELQIMSSEGSWPDSNLRFPFPGEPIPIPQEGKVRLAVTIRGGKQLQFYYALEVEEELKKIGPVLDASIVSDECGGHKEHGSFTGAMIGVAASDLNGTAARAIFDYFLYRPVSHESDRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGE2</accession>
    <name>G0SGE2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">magnesium chelatase</fullName>
            <ecNumber evidence="1">6.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0066000</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism.</text>
    </comment>
    <dbReference type="EC" id="6.6.1.1" evidence="1"/>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696899.1">
        <property type="nucleotide sequence ID" value="XM_006696836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGE2"/>
    <dbReference type="GeneID" id="18260638"/>
    <dbReference type="KEGG" id="cthr:CTHT_0066000"/>
    <dbReference type="eggNOG" id="ENOG502QQMN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034390_0_0_1"/>
    <dbReference type="OMA" id="HWHDPED"/>
    <dbReference type="OrthoDB" id="5582146at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016851">
        <property type="term" value="F:magnesium chelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.80">
        <property type="entry name" value="Magnesium chelatase subunit I, C-Terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052041">
        <property type="entry name" value="Nucleic_acid_metab_PIN/TRAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11603">
        <property type="entry name" value="AAA FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11603:SF132">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ChlI/MoxR AAA lid" evidence="4">
        <location>
            <begin position="391"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="82"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="126"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="247"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="344"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS17281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="487" mass="51633" checksum="954ED4C65AAA623E" modified="2011-10-19" version="1">MDDILAKVHTLTDLELATLLCLIAREHCLISTHPSSIDDLAAELSLVASKTFGLTASIISCHKHMTLDEFATGLLVPCPASSPSVNTLSVSPYRPRHYEHQGQTSSTAGPSSSAAAAAAAAAAAGGREGGREGGGGGGGYFLSAGVSSSPRHNPSMSPPVMSASQPPRIANIILAKNLHLTPRVVQIQALELLRTRRIFTRTSVQTAPKQFLFIALVGANSGGEARVTPHLNDFFYIGHWHDPDEDGFPHLEGELDEDGIRNDDASNNGDNNDADGRSISSLSTTSVLVKHPSHSSTQNQQGPDQAASRQSSRRRWLSRSNSSMISTVSSTNLPPPLQRHPSLLTPSSDPEASSPTPLLTPTDISQLSLASTAAYISPAVLRYTHNIITFLRTHRAVAGGVSPTATRHLEQLSRSLAALHGIDYVTPSLVAMAVRKVYLHRLGLVSEPEGERSVQWGGDLEAVREAMAGWTVEGVLEEVLGVVGVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGK1</accession>
    <name>G0SGK1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0066620</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696958.1">
        <property type="nucleotide sequence ID" value="XM_006696895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGK1"/>
    <dbReference type="GeneID" id="18260700"/>
    <dbReference type="KEGG" id="cthr:CTHT_0066620"/>
    <dbReference type="eggNOG" id="ENOG502S9PF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009397_8_0_1"/>
    <dbReference type="OMA" id="DPSFMKA"/>
    <dbReference type="OrthoDB" id="3879658at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08999">
        <property type="entry name" value="GH43_ABN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="413" mass="42503" checksum="2B2F4D1C64ADEEB8" modified="2011-10-19" version="1">MPRLVPGQTTAAPEEGANGSNSNSGSNTTSGGSTSSGSNSKTPLLAVDFPDPCIVRDPLSGTWYGFGTGSWQSVLSDSTGTTTFKNIQAASAPALGGPWTYLPDANPLPTAGNWTSYPQENPTTDTLTWAPSVVRINLTAAGDTSQTYQYVMYYSALHPSTTINITTSAANPVDNTTIVTNTTVTTTDTTLHCIGAALSPPNEPLGPYTPLPTPLICPLSQGGAIDPSGFVDPATGRRYILYKVDGNSLGGGGECNNGVSPERGTPIMLQEVDALDGVTLIGEPVQVLDRDAAVDGPLVEAPELALLNGDKDDDDGGVYVLLYSNHCWDGPLYSVNYAVSKVADGGSVKGPFKRAVGAKPLIQTGDGFNITAPGGAAWAEGGGWIVFHGNCEQGRCLFGAAIAAATNGNVTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGL3</accession>
    <name>G0SGL3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA N(3)-methylcytidine methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0066740</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696970.1">
        <property type="nucleotide sequence ID" value="XM_006696907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGL3"/>
    <dbReference type="STRING" id="759272.G0SGL3"/>
    <dbReference type="GeneID" id="18260712"/>
    <dbReference type="KEGG" id="cthr:CTHT_0066740"/>
    <dbReference type="eggNOG" id="KOG2361">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029724_1_1_1"/>
    <dbReference type="OMA" id="PAKYWDI"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052735">
        <property type="term" value="F:tRNA (cytidine-3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000221">
        <property type="entry name" value="Methyltransferase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026113">
        <property type="entry name" value="METTL2/6/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809:SF11">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037755">
        <property type="entry name" value="Mettl2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="6">
        <location>
            <begin position="182"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="25"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS17352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="392" mass="45340" checksum="76AC2348D43DDCB8" modified="2011-10-19" version="1">MTTDSPAPAAAAPAAVAEKQLAAEIASLEIAEDPSSDQQEQKQEQKQEQKQEQKQEQNKEEQMQVPPHRSHDPKNNQKRSDPFQFGSRYLTEEDDVFEFNAWDHVETDDAYKAYAEQQYAMQRAAPVSEFDKHRFNSDPAKWWNRFYQNNTSHFFKDRKWLQQEFPVLEQVTREDAGPKVILEIGAGAGNTAFPILAKNKNPQLKLHACDFSKKAVEVMRNHESYNPELMQADVWDVAGEELPPGLEENSVDVAIMIFIFSALSPKQWKKAVENVYRVLKPGGEVCFRDYGRGDLAQVRFRKGRYLEENFYIRGDGTRVYFFEKEELADIWTGKKFAKENGDADEKEGVPFSFEIENLAVDHRLLVNRAKKLKMYRCWIQGKFRKPATQNTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGX3</accession>
    <name>G0SGX3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0067890</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIM50 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697080.1">
        <property type="nucleotide sequence ID" value="XM_006697017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGX3"/>
    <dbReference type="STRING" id="759272.G0SGX3"/>
    <dbReference type="GeneID" id="18260827"/>
    <dbReference type="KEGG" id="cthr:CTHT_0067890"/>
    <dbReference type="eggNOG" id="KOG1605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_521756_0_0_1"/>
    <dbReference type="OrthoDB" id="1711508at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FCP1 homology" evidence="3">
        <location>
            <begin position="298"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="198"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="483"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="495"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="513"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS17462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="522" mass="58535" checksum="663F859A07BD2B69" modified="2011-10-19" version="1">MDNGQLGDGTPPPKRSGEPDTPASVQSSAMDCSSSTNSRSTPSPGRTPAQVQTVSNRSGQPAQLIQNDDDDDYEPPAVIPPEKDDVYRSPLVDVPIRDDGYESRPANPPAQSTSAFTPPVAQPFPAFAPCQFAPYQFVPYQPYFAQMGQYIGDMGQYTRHLGQYFRQIGQFPWPMANGSFGPFFATMPAYQQARAYPTMPQPQVPTPTAGNLWRNFPQSQNTPAPIVGEHSSQLQNNSPALKQEKSPEALPSPRSPRMMKKDGRHPDPINTPSKESGGVPNPTPSYLKRASQEPVAVEEPRPLLIVIDLNGTLLYRPDKHKPTKYQTRPLASQFIRKCIEKYRVVIWSSTRDENVRIICQKLLSPDLLSRVVAIWGRTKFGLSPSDFKKRTMCYKRLTKLWADPRVAQSYPAGAEGEHGWDQSNTILIDDTPEKARAEPYNAIIVPEYTGEQNEQPRVLECVEQYLETLRYQADVSAYMRVNPFALPEKQTEEKKKRKKRKRKRAGSESGEVAQQEQEQAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0SH45</accession>
    <name>G0SH45_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serum paraoxonase/arylesterase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0068650</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697152.1">
        <property type="nucleotide sequence ID" value="XM_006697089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SH45"/>
    <dbReference type="GeneID" id="18260903"/>
    <dbReference type="KEGG" id="cthr:CTHT_0068650"/>
    <dbReference type="eggNOG" id="ENOG502QUCT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033924_0_0_1"/>
    <dbReference type="OMA" id="NDHHYRE"/>
    <dbReference type="OrthoDB" id="5307922at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051288">
        <property type="entry name" value="Serum_paraoxonase/arylesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799">
        <property type="entry name" value="PARAOXONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799:SF12">
        <property type="entry name" value="PARAOXONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS17534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="46864" checksum="4CCDF4EB691EAEDC" modified="2011-10-19" version="1">MKWLTLSLFGALLSWAIYSIAPFVSRTITVFGLFRRYPEGTTTTDETLQAIPDTTHCEDLHYHAPSGTLFTACEDNLEGRHKWFPPLANFDDPEVGSKGLGSIHVIDPKTMKSQRLKFDNFNGPFITHGIDVIPDKDRPEGEAVYIFAVNHVPEVQASGAKGPSARSQLEVFYHIIGTSSVKHLRSIWHPLIRTPNDVVALSPTSLYVTNDHFYREHGIMRTIEDMYIKSDWSDIVHIQLDSLKAPSADAGVTARIALAGLHNTNGIGHGRTEDEILISSCTSGVLNIAQVPSDPSTGNLTVVEAIEIDHIADNPSYFADPYASAVDDRSGFLEAGVSRAADLLHTMRDPNAKDPVMVTYLRPKRPEEGGGWEKRVLLDDDGARLRSASAAVLVAIDPASEPNGGSRKAWLFATGFLSKNVIAVKVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0SH53</accession>
    <name>G0SH53_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0068730</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. LDAH family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697160.1">
        <property type="nucleotide sequence ID" value="XM_006697097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SH53"/>
    <dbReference type="GeneID" id="18260911"/>
    <dbReference type="KEGG" id="cthr:CTHT_0068730"/>
    <dbReference type="eggNOG" id="KOG3975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018394_3_0_1"/>
    <dbReference type="OMA" id="LIGYYHT"/>
    <dbReference type="OrthoDB" id="448051at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019363">
        <property type="entry name" value="LDAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390:SF0">
        <property type="entry name" value="LIPID DROPLET-ASSOCIATED HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10230">
        <property type="entry name" value="LIDHydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS17542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="42965" checksum="C3EAD4ED29F069F9" modified="2011-10-19" version="1">MPRRYSMPDHTDNPVSAYEDKVPFLEYPSTRRDDPTRKQCLIYFIPGNPGLIAYYEPFLSALRKLLDEVEARADCSHAFTIYGRNLLGFDDGDHFPLFGTPTGYGDGSKTEPFSFKDIIASACDWVRAVDVRLPRHPDGSLRHYDETILIGHSVGAYIALEIFNHHHAAYKFPEIVDDWAGLKLKAGILLFPTISHIARSSKGWKLDFIRRTPILNWLAPYIAKGLVSLWPNWALEGILRYALRMPDHAVAATMRFLRSHDGILQALHMGRDEMMTITEVRWSDDLWQVQDVDQRLKQRTKFVFYYAKSDHWVDNKSRDEFIEQRMRDVENKLEFIIDQDDIPHAFCLNHSEQVAKKVKGWVENIADLTPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0SH68</accession>
    <name>G0SH68_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0068910</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SWI5/SAE3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697175.1">
        <property type="nucleotide sequence ID" value="XM_006697112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SH68"/>
    <dbReference type="GeneID" id="18260929"/>
    <dbReference type="KEGG" id="cthr:CTHT_0068910"/>
    <dbReference type="eggNOG" id="KOG2868">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1175714_0_0_1"/>
    <dbReference type="OrthoDB" id="255837at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032798">
        <property type="term" value="C:Swi5-Sfr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034974">
        <property type="term" value="C:Swi5-Swi2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010772">
        <property type="term" value="P:meiotic DNA recombinase assembly involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010760">
        <property type="entry name" value="DNA-repair_Swi5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28529">
        <property type="entry name" value="DNA REPAIR PROTEIN SWI5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28529:SF2">
        <property type="entry name" value="DNA REPAIR PROTEIN SWI5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07061">
        <property type="entry name" value="Swi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS17557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="220" mass="24439" checksum="CFCC61C71FE8E720" modified="2011-10-19" version="1">MATSVGLNHRKSKTTSKNNDDVIAAAVQAELSHVAAFEGWLLERIEADGDGAGVLARVQEHLLQYKLGLLESTLDSKQDEHLKDWSMHVSVHDNGSNGQAIIVTVPGSLKPIEIVPKDDEEAAYLLSDKYLGFMVKACRSFAHSQASLRSLFQLAKEIDQETSHLRQTPEVTIQTYIRHLKEYNDMKDIAQQLIGLVAENRGVPVGSLYRNREFGVTEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHA0</accession>
    <name>G0SHA0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="15">ATPase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0069260</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ABC-type transporter; part of the gene cluster that mediates the biosynthesis of the phomopsins, a group of hexapeptide mycotoxins which infects lupins and causes lupinosis disease in livestock.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697207.1">
        <property type="nucleotide sequence ID" value="XM_006697144.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0SHA0"/>
    <dbReference type="GeneID" id="18260964"/>
    <dbReference type="KEGG" id="cthr:CTHT_0069260"/>
    <dbReference type="eggNOG" id="KOG0054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_27_5_1"/>
    <dbReference type="OMA" id="LCTHAIK"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000055">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000066">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001854">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF345">
        <property type="entry name" value="ABC MULTIDRUG TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="311"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="411"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="491"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="526"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="899"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="941"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1040"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1122"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="280"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="602"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="902"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1215"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="573"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="837"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1311"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1313"/>
            <end position="1329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00059074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS17589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1504" mass="166014" checksum="6993E7486BF2DD7B" modified="2011-10-19" version="1">MDFAGCPDDEKFGPVVQGCRDDFDFTIKFEKIFFSLIPASLLIAAALCRVVYLLRRPVIVGGRVLQVAKVATVVVYAALQFSLLLLSSINAQRFRALFVSSDTLSLASALCMLVLSFLEHSRSPRPSTLLSGYLFVTILFDIAQVRTFWLASTNSKELAFSRLSTCGVVIKALMILLEARSKSKWIIQWDVKEHSPEETTGLYGLGAYLWLNALFLKGYRKVLEVNDLYPLDNDMAAESLHARLSHHLDVSTFKGKKHGLAVALAKALAVPLILPVVPRVALGAFRFCQPFIIESLLKHLGKKDEVSPDNIGYGLIGATILVYVGIAVANAFYWYFQERVLYKARGLMAKAIYMKTTELKITASDDSAALTLMSTDIDRILLGFHPIHEFWANIIQVALACWLLSRQIGPSFVATLIVVTACFLWTAIQAKFAGPRQKIWMEKIQRRVGLTSTIIGQMKHLKISGLSRPIEQSIQALRVDELKASARYRQLMVFAAFIGLMPGFLSPPVTFAFASRKLDVTTIFTSLSYITLLTEPLGLIFQWFPMLVGTFTCLNRIQAFLEQDARHDYREQTVRGQTTVTAPADTEKSVDEGSPSASSARLIVRGGAFGWDPERPVLKDINFEIPASRLTIVIGPVASGKTTLCKALLGEVPAAHGHVSMLGPSLSSKIGYCDQNPYLCNETIRENIIGFRLFDRERYDEVIEATMLKPDLALLPQGDQTKIGSSGITLSGGQKQRVAIARALYLDTDFYIFDDILSGLDADTEKQVFLRVFSPSGLIRKRNATAVLCTHSVHHLPSADHIIVLGQDGTLLEQGTFQELMANDKYVSTLGVLDSSESNSEGSWATPKEDVAPSDGSARVLPAKTQLPVMSEAEARARMTGDWAVYRHYFARIGLLSKVTFIVGGVSWGFFLNFSTIWLKFWSEDVQSPKQSHSNAFWNGLYALFQMCAIFTLLVVAMIMMIMMVSISGAKLHQEALATVINAPLKFFATTDTGAVVNLFSQDMTLVDIQLPNAFVNLVLDAWGVIGMAAVIAATSPYLVITYPFLCAVLYVLQKFYLRTSRQMRLLDLEAKSPLYSHFIDTLKGIDTFRAFGWIQDSIAKNSKLLDTSQRPAYLLAMIQRWLAFTLEMIVALLAVAVVVLATQLRSNQALAGAGLVTLMVFGDNLTAIIRFYTQLETSIGAVSRLKSFGEKVESENRPGEDLVPPKEWPRKGEIEIKGVSASYGAADQEEDEKIHLALNDINLHISPGEKVAICGRSGSGKSSLLLLLLRLLDPTDTNTSTLTLDSLPLTRIPRSLLRDRLIAIPQEPVFLPSTTSTSSPPPSSGSESSSKKAVTATTIETNLDPDYLATREDCIAALQRVTLWDFISSRGGLDAQLATDTFSQGQKQLFSLARAIVRRRVRARETGNDSDNGGDGGVLLLDEVSSSVDRETEETMARVIAEEFKGWTVVMVSHRLGMVMRWFDRVVVMDKGGIVETGRPRELVEQEGSRFRELWLAQAGGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHG2</accession>
    <name>G0SHG2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cysteine synthase 1</fullName>
            <ecNumber evidence="5">2.5.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">O-acetylserine (thiol)-lyase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">O-acetylserine sulfhydrylase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">O-succinylserine sulfhydrylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CTHT_0069910</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of O-succinyl-L-serine into cysteine, the last step in the cysteine biosynthesis pathway. Can also use O-acetyl-L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-succinyl-L-serine + hydrogen sulfide = L-cysteine + succinate</text>
            <dbReference type="Rhea" id="RHEA:53816"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:136856"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="5"/>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697269.1">
        <property type="nucleotide sequence ID" value="XM_006697206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHG2"/>
    <dbReference type="STRING" id="759272.G0SHG2"/>
    <dbReference type="GeneID" id="18261029"/>
    <dbReference type="KEGG" id="cthr:CTHT_0069910"/>
    <dbReference type="eggNOG" id="KOG1481">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021018_1_0_1"/>
    <dbReference type="OMA" id="VVTVFWD"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000011">
        <property type="entry name" value="Cysteine synthase (o-acetylserine)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000049">
        <property type="entry name" value="Cysteine synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007989">
        <property type="entry name" value="PRK10717.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="19">
        <location>
            <begin position="42"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00072087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00078262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00081847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGS17651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="375" mass="40344" checksum="33C075E016A76378" modified="2011-10-19" version="1">MFRHGARAFATSASRLAVAAAAEPSARLVNVARAQGISRGLTEAIGNTPLIRLNRLSEETGCEILGKAEFMNPGGSVKDRAALYIVKDAEERGLLRPGGTVVEGTAGNTGIGLAHVCRSRGYKLVIYMPNTQSQGKIDLLRLLGAEVYPVPAVPFDNPNNYNHQAKRHAESLPNAVWTNQFDNTANRRAHIETTGPEIWEQTNGKVDAFTCATGTAGTLAGITRYLKEVSNGRVKSFLADPPGSVLHSYIQSGGKLIERTGSSITEGIGQGRITDNLAPDVGLLDGSLHIPDEKTIEMVYRCLDEEGLYLGASSALNVVAAKEVAEKLGKGHTVVTILADGAYRYADRLFSRKWLESKNLLSAIPEHLQKYVVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHN0</accession>
    <name>G0SHN0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vacuolar protein sorting-associated protein 21-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0070620</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697337.1">
        <property type="nucleotide sequence ID" value="XM_006697274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHN0"/>
    <dbReference type="STRING" id="759272.G0SHN0"/>
    <dbReference type="GeneID" id="18261100"/>
    <dbReference type="KEGG" id="cthr:CTHT_0070620"/>
    <dbReference type="eggNOG" id="KOG0092">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_10_2_1"/>
    <dbReference type="OMA" id="GASFFRY"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000611">
        <property type="entry name" value="RAB GTPase Vps21/Ypt51, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="242" mass="25696" checksum="9F40459EA833D513" modified="2011-10-19" version="1">MADQNAPRPSSSVKLVLLGEAAVGKSSLVLRFVNNDFQENKEPTIGAAFLTQKCNLPTRTIKFEIWDTAGQERFASLAPMYYRNAQAALVVYDLTKPSSLIKAKHWVAELQRQASPGIVIALVGNKLDLTNDGGAGGAGVGDQAGEDDAAAAGGEEESGDARKISTEEAKAYAEEEGLLFFETSAKTGYNVNEVFTAIALAIPETSLKTTRGPGSHAATRTEEQRVNLNTARESGQENACAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHP1</accession>
    <name>G0SHP1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">M-phase inducer phosphatase</fullName>
            <ecNumber evidence="2 10">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0072850</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the MPI phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2 10"/>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS16961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697543.1">
        <property type="nucleotide sequence ID" value="XM_006697480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHP1"/>
    <dbReference type="STRING" id="759272.G0SHP1"/>
    <dbReference type="GeneID" id="18261323"/>
    <dbReference type="KEGG" id="cthr:CTHT_0072850"/>
    <dbReference type="eggNOG" id="KOG3772">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017900_0_0_1"/>
    <dbReference type="OMA" id="HSPQMED"/>
    <dbReference type="OrthoDB" id="26523at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110032">
        <property type="term" value="P:positive regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01530">
        <property type="entry name" value="Cdc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000021">
        <property type="entry name" value="M-phase inducer phosphatase cdc-25.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000751">
        <property type="entry name" value="MPI_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF17">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00716">
        <property type="entry name" value="MPIPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6 10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="12">
        <location>
            <begin position="353"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="181"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS16961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="540" mass="60332" checksum="4968D57709A59209" modified="2011-10-19" version="1">MDASSPLAAMRPAPASPFNQGSVFGKHLRANRLTGTYKFQRNNSDLFKSVRGSSPAASLAADLSQNFKLNDASSPMFPTPRRSLFTTATMIDASEGRDYATTPPLPESPALDDSDMMDMSPLPQKASRLAHVELSSPTPGADEMLLESPTPHTHSLDTVKSGAVDRRKLCLKRPSLLRTKGLTSNGLTSRAHGDVQAPPSFRLSTGDDSNISTSSSPMSLSECFEDSPPQEHCSLNIESPTTMATTRARAHLSALHSVRDGSPITARRSANTFARTRRQYRRSLSMFENPEDIIKGKKDGPTAAPSTLQSIMDMEEPHQLILPHFFTDDPTDTIPRITRQTLLDVLDGKYSQHYDHKMVIDCRFEYEYEGGHIDGAVNYNDKELLADHLFRHPMEGRTLLIFHCEYSAHRAPIMARYIRSEDRNYNADNYPKLTYPEIYILDGGYSSFFCEHRERCYPQAYVEMNDAKHVNTCEREMSRLRQQRKGLSRAQTYAFGQRGQSLDESPTALGRGHRDREFSKLLAASPLGSDRAGTRRVASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHU1</accession>
    <name>G0SHU1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0073360</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697593.1">
        <property type="nucleotide sequence ID" value="XM_006697530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHU1"/>
    <dbReference type="GeneID" id="18261374"/>
    <dbReference type="KEGG" id="cthr:CTHT_0073360"/>
    <dbReference type="eggNOG" id="ENOG502RJJE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_687207_0_0_1"/>
    <dbReference type="OMA" id="HPRAWED"/>
    <dbReference type="OrthoDB" id="3492129at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="364" mass="40258" checksum="321B6B0680FBDC2D" modified="2011-10-19" version="1">MRKQTRARPELHPVQTSVDDRKSSPTPSAMFSATSSLFPAITRTDGLLSPICPPQSPGYDLVERKRRRAVDEHHDRREKYDAPLPMTARSLSPISEHMMSDRRPFTANLPPPSARVISPLSPDPHPEHSRRPTLAEETRSILLSGLPNDATRQEAAAHSPPSDRRQSLPASILSARRSSIELQQKLEERGRTYNSVYFVAAVALRRASDSSSSVNEGESGKTSPIDGDTVTIRARIRPCAPDRKPFLVKRTFDRTTLPELPSLGARRLSAISPRSSIALSPNPRRSSVAVEVDFGPSGADKSPVRCSNPVPIHLLYALIYFPILGHLMCSKHINPHDKIDLPLPSPEAWLQTVQHGMWALSLSF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2014-02-19" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>P0CT45</accession>
    <name>IPI1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName>Pre-rRNA-processing protein IPI1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">IPI1</name>
        <name type="ORF">CTHT_0115680</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IPI1/TEX10 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PDB" id="8PV4">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="CS=1-338"/>
    </dbReference>
    <dbReference type="PDB" id="8PV6">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.94 A"/>
        <property type="chains" value="CS=1-338"/>
    </dbReference>
    <dbReference type="PDB" id="8PV8">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.91 A"/>
        <property type="chains" value="CS=1-338"/>
    </dbReference>
    <dbReference type="PDBsum" id="8PV4"/>
    <dbReference type="PDBsum" id="8PV6"/>
    <dbReference type="PDBsum" id="8PV8"/>
    <dbReference type="AlphaFoldDB" id="P0CT45"/>
    <dbReference type="EMDB" id="EMD-17953"/>
    <dbReference type="EMDB" id="EMD-17955"/>
    <dbReference type="EMDB" id="EMD-17957"/>
    <dbReference type="SMR" id="P0CT45"/>
    <dbReference type="STRING" id="759272.P0CT45"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024679">
        <property type="entry name" value="Ipi1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF2">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12333">
        <property type="entry name" value="Ipi1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000425283" description="Pre-rRNA-processing protein IPI1">
        <location>
            <begin position="1"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P38803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="338" mass="37390" checksum="812219A96F362661" modified="2014-02-19" version="1">MGSSSKKKKEKQKDFQKPKLKVGKPKQKPSNFTDTSFKTKSIVVNQQTLTTEGLDSAELFKQNLTLAVNAKSDNQRRDALAYVTNQLSANPANNPVGTVGVLTKVLPLITDGASSVRVQLLKLFRTLPPQEVRPHAEKILLYIRGGMTHLSNDVRTDTLNVLDWLLEVAGDEVVSCPGGWLKTLNSFSSMLGWNPNVSSAMTTKGWTSAPKATLGMKKGPESQAKQIQVLAKFLQTGFRPEEPLPYKPRAYWDNIYRLPTTPNPFAYLNLFGLPRDEDSEMYPDRMSRLRVFDMKWRAAITSGMETAKKEGGTVGRAAAILDKALKASLESDGSMQVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0RY28</accession>
    <name>G0RY28_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0005180</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691056.1">
        <property type="nucleotide sequence ID" value="XM_006690993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RY28"/>
    <dbReference type="STRING" id="759272.G0RY28"/>
    <dbReference type="GeneID" id="18254556"/>
    <dbReference type="KEGG" id="cthr:CTHT_0005180"/>
    <dbReference type="eggNOG" id="ENOG502S4HG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_444097_0_0_1"/>
    <dbReference type="OrthoDB" id="2367685at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="17"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="615" mass="65114" checksum="3FE31ACF3ECFB9F8" modified="2011-10-19" version="1">MAGPPSPGGEGPTYAPPPLPAGWIAQWDAQSKKYYFVQLSTGTSQWEVPTEPAPVGGIDDPANPANGMPQAPAEIIVHPDGSQTARYPDGRLEPVNPREDGTTGPVPAGTRGVGHDGSSDRGLGSLIGGALNTFGNKQGKSGVGLAGQVLGSLAGGGHSSSSHGSSGGGLGLAGQVLGTLAGGSHSSGHSSGSGGLGGKLAGQLASNLFGKSSSSHGSGSGASNLLGGHGSANLVTGLVGAAASGLFGGGSSKHRDNPFGYTNNPTPGGYTGTAPPPQYQPPSQPGTPNIVPSYQGGQPTTSQPHSAYGQSPAGQQYPPSYSAPPQHGQPYGQQNYGQSPPVPAPYPTSTSYGAASSYYNSAPASGYPPQSQYGQGRGQQRREEKEEEEKWQRQEEQKKWLESELERWRPQVEERLSEIKELLESGMEALRCEVNLHLPAVDQLRLELGTLRRHADDQLAAIRSHMNDQLFQIQQQQWIQQTNARNRLNGIDERLLQLEEELGKEKQRQAREEKEKRYRQCRERLSQARTRHLQQIKDAEEGKFDISTLPEPLRQPFLSSSPYSLRDAAPSSQPDPGLHAPPPSEDRSPPRPRPRLRSCSGSGSSNVGPDKKKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0RY59</accession>
    <name>G0RY59_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0005530</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691087.1">
        <property type="nucleotide sequence ID" value="XM_006691024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RY59"/>
    <dbReference type="STRING" id="759272.G0RY59"/>
    <dbReference type="GeneID" id="18254591"/>
    <dbReference type="KEGG" id="cthr:CTHT_0005530"/>
    <dbReference type="eggNOG" id="KOG2940">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046586_0_0_1"/>
    <dbReference type="OMA" id="YEVVYGH"/>
    <dbReference type="OrthoDB" id="16816at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050602">
        <property type="entry name" value="Malonyl-ACP_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090:SF1">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="118"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS23845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="350" mass="38914" checksum="74B592DE5A9288A6" modified="2011-10-19" version="1">MRVNLARVFRPQNLQAQLSQIGRRTYALESSRGAIFRVFNSRTKWLQKERAASNPELSRQTDYLKDEVARRDIKRHFPRVLDLGANSCNIARALVRENPDPDPAHPESPPLAVSSNIAELVAAETSSALLHRDADLPFNTQVPSLKITRYVLEDEERLPFDRDSFDCVLSSCSLHWINDLPGVLSQINGVLKPDCPFIGAMLGGDTLFELRTSIQLAEQERRGGISPHVSPLADVRDVGGLLQKAGFQMLTVDVEDIVVDYPDMFALMEDLQAMGEGNCVLNREMGPIGRDVLLAADAIYKALHGNEDGSIPATFRIIHMIGWKEGENQPKPLKRGSGQVSLKDVLEKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G0RY89</accession>
    <name>G0RY89_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA wybutosine-synthesizing protein 4</fullName>
            <ecNumber evidence="5">2.1.1.290</ecNumber>
            <ecNumber evidence="4">2.3.1.231</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Leucine carboxyl methyltransferase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-methoxycarbonyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CTHT_0005830</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine + CO2 = wybutosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:37119"/>
            <dbReference type="Rhea" id="RHEA-COMP:11844"/>
            <dbReference type="Rhea" id="RHEA-COMP:11847"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73544"/>
            <dbReference type="ChEBI" id="CHEBI:74275"/>
            <dbReference type="EC" id="2.3.1.231"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36903"/>
            <dbReference type="Rhea" id="RHEA-COMP:10379"/>
            <dbReference type="Rhea" id="RHEA-COMP:11844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73543"/>
            <dbReference type="ChEBI" id="CHEBI:74275"/>
            <dbReference type="EC" id="2.1.1.290"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methyltransferase superfamily. LCMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.290" evidence="5"/>
    <dbReference type="EC" id="2.3.1.231" evidence="4"/>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691117.1">
        <property type="nucleotide sequence ID" value="XM_006691054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RY89"/>
    <dbReference type="STRING" id="759272.G0RY89"/>
    <dbReference type="GeneID" id="18254621"/>
    <dbReference type="KEGG" id="cthr:CTHT_0005830"/>
    <dbReference type="eggNOG" id="KOG2132">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2918">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002761_1_0_1"/>
    <dbReference type="OMA" id="FCILEQF"/>
    <dbReference type="OrthoDB" id="47172at2759"/>
    <dbReference type="UniPathway" id="UPA00375"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000043">
        <property type="entry name" value="tRNA wybutosine-synthesizing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46529">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46529:SF1">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13418">
        <property type="entry name" value="Beta-prop_TYW4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 18" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="JmjC" evidence="17">
        <location>
            <begin position="856"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGS23875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1046" mass="116018" checksum="E8D1C1B3BE830A5C" modified="2011-10-19" version="1">MPKPTNVSFPRGKSAQAKADDQVMATNSSSIVSKRSVERLYHPNEPHFFRYFVPKPQRRAPLINRGYWLRLRVIDVLVRDFLHDAKKRGRRAVVVNLGCGSDVLPWQCLTRYPEESKRVLFVDVDFPDLIEHKRQTVLNTPELVGAFTGLKGPGETVKPVVLQTDQYVQIGCDLRDLVTFRKGLDAVLRAELAECEFIFVAEVSITYMETEGADRVIQWASTLGNAEFILLEQILPDGEDHPFASTMLNHFQKLNTPLKSVKTYATITDQHTRFLNHGWPSVRVWTLWQAWADETFLPADERRRLDEIEPFDEWEEFALFGSHYCVVHARTEIEGTTTYNPPPAVPKTDGIPIKEVPLQFDPCPGQKGQRRFAAAMQLSSDRPKEQPVLLNVLGLGIKTRLQSCDLFSYGVEPGSEATFAFRGGIGPAARMCHSLTDLGSVGVLLAGGRGSPSTPVKDCWLFDRSLRAWRRTDDLPVPLYRHSVVALGESGMALLVGGRGEKDLFEGALLYHPEAGWVDCQVAGERPEATYGAVLACVGASRAGYFAGIYTGGIKDGLIADQLLRWELDISDVKKPSIRFTSMQVKGVDNEQIARWLFGRFGATCLQHSEGFFLLGGVTRDHLLSRADEVLSFAVSTDELIITKRVLGQCAQSGVPVPRPLLAGHSAISLPDGSITIVGGGATCFSMGTFWNGGIYTLRFAESDRNETAASQLASRWTFERAVDIVPGEQVTPTRTIPQVNGEKARITPIPNIKLQSPDEFLKILREGRPVVFKGLDLGSCVSSWTLDYLESKIGTDRKVVIHEAATQAMDFNSKNFRYVTTDFGDFARRAQRGDKLYLRALSQDKPSEKPTVLADDYPEIAADFVLPPQLSSVKERLFSSVLRLSGPVNMWLHYDVMANVYCQIGGSKRMVLFPPADVEYFSFAPGASSSSVDVFSTLGTPELAATHPHVAELGPGDVLFLPALWLHTAMPTSSVSIAVNVFFRDLDNTSYAPGRDVYGNRDLGAYEKGRQDIARIANSFSKLPAEVREFYLLRLADELRSKARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYI8</accession>
    <name>G0RYI8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0006850</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691216.1">
        <property type="nucleotide sequence ID" value="XM_006691153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYI8"/>
    <dbReference type="GeneID" id="18254723"/>
    <dbReference type="KEGG" id="cthr:CTHT_0006850"/>
    <dbReference type="HOGENOM" id="CLU_2621818_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="78" mass="8805" checksum="182A3935607F7150" modified="2011-10-19" version="1">MPTQPTIQDRNVGFLKQTNQRKSLRDQPIRSGYPEQPTRQPSSIPALRKARDVKEINALVSVAEKLYAANENVEKSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYJ6</accession>
    <name>G0RYJ6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0006930</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691224.1">
        <property type="nucleotide sequence ID" value="XM_006691161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYJ6"/>
    <dbReference type="STRING" id="759272.G0RYJ6"/>
    <dbReference type="GeneID" id="18254731"/>
    <dbReference type="KEGG" id="cthr:CTHT_0006930"/>
    <dbReference type="eggNOG" id="KOG0698">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021251_2_0_1"/>
    <dbReference type="OMA" id="FKGGSTC"/>
    <dbReference type="OrthoDB" id="416093at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF589">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE [ACETYL-TRANSFERRING]]-PHOSPHATASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="6">
        <location>
            <begin position="117"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="170"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS23982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="462" mass="50490" checksum="A7902F8B8DED8DF3" modified="2011-10-19" version="1">MTSLAKTSRFLRVPSALCLPSRRNFHNYFVSHLPSASLFPDSRSTAGPSAPNRDLTVVRIPLRSAKHHFGVAVSRGQRIQNEDTNQAGTITMPAFAKRPPISLVRGQDAAAAAKAAGIGTTAASALGDPQVFYFAVFDGHGGTECSDFLRDELHGYIEQAAADLQLQSSLQKKDDPKKLPSSLQDPSTLSSPTILPQHDHEVPPSESSTPRPLRLQSDLLQEYRRTIGGYWRRFRPSCFTIPPIPSSRDPNPPPPLTSQGPITLETVLTYAFLRADLDFVTAQARDTRVLLCETKTGLAVPLTADHRPSSPTESRRLRRYLSDSLVTDSFGEERLHGLANSRSFGDMGSKRIGVSAEPDIVRVDLHPAQYSFMVLCSDGVSGTLSDQEIVDIVKEAGTPEEGARSVVEYATEVSSDGDNATCLVVRLGGWERRCEGGLGSMGTKEVREMRRVEAEDPRRRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYM4</accession>
    <name>G0RYM4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ars binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0007210</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS24010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691252.1">
        <property type="nucleotide sequence ID" value="XM_006691189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYM4"/>
    <dbReference type="STRING" id="759272.G0RYM4"/>
    <dbReference type="GeneID" id="18254759"/>
    <dbReference type="KEGG" id="cthr:CTHT_0007210"/>
    <dbReference type="eggNOG" id="ENOG502QV85">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014337_0_0_1"/>
    <dbReference type="OMA" id="RRGPKNV"/>
    <dbReference type="OrthoDB" id="2104370at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018562">
        <property type="entry name" value="ARS-binding_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42048">
        <property type="entry name" value="ARS-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42048:SF1">
        <property type="entry name" value="ARS-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09441">
        <property type="entry name" value="Abp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="292"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="529"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="722"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="800"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="392"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="439"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="493"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="554"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="722"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="736"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS24010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="828" mass="88391" checksum="DBB9E5A53817D9AF" modified="2011-10-19" version="1">MPPSRALPSREGITSPSALEEAYIAFILYCNPCVPLTTDPSPLREAFRTPPKSDGKTFSTYTLFTLIRKLESRELKTWAELALQLGVDPPDAEKGQSAQKIQQYAVRLKRWMRAMHVDAFFDYLMGRESEYWTCVPPAEVSPLDIERDGVAAEDDMALRALIPAVKPRRGRRKLDAADEEASSRSRRESPQEGEDGRVQDREPWTAFPDGRGRAFVFPPPPRPPRPPPPPPPLPPPPPPPPGKSAQGGNGAQWLGSDLVQTPLSAYPAAPQSAITPSTRASFWADEPKSAIALTPSGAKPRSVSRRHGAKVVSSAWRSGGLGATGKTRGRPPKRGLESEGPFSAFPTSDGPVFRFPSPVRERPEEVPKSAVPTGSGSGVEPGTSAQATASKTSVAAQAPSTQAQTTVSAQASQTPASTSTQAPAAQPTPAQPASARPLEPLPPLHPPTQPPSQPVRSRSQPAPADPNNPRPAKRSRLSLQVPPRIGGEVRLATPPPAVPPASAVPPAPVMPPALMTVNGQAADVALQNTSKQSKEPKGTGMGPGSFEAFYPPSTTTTNTTRPNNNDAATNASTAAPSSNKITSSSDSMTNSTTTPTPPPNRQRVFFTNPHDRTNKSSVEAFFTSSILSAEWYDPSHRRIPPCSVEEAHAFAQRVIENLLETSESKEKFLINLAALVGGNLMLHKGSLKITRLGEDEKEVRYLVRWELRYGDLVGSWGMEERVKKRRGDKEGGKGGASVDGSAAASVNGSAGTNSAEPSVAHGSVESGNGSGSGDGGEETSVNGDGSNKNNKGEGYWEQRYREMAAALKERDDELARLKQRIIEAVRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYN1</accession>
    <name>G0RYN1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0007280</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS24017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691259.1">
        <property type="nucleotide sequence ID" value="XM_006691196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYN1"/>
    <dbReference type="STRING" id="759272.G0RYN1"/>
    <dbReference type="GeneID" id="18254766"/>
    <dbReference type="KEGG" id="cthr:CTHT_0007280"/>
    <dbReference type="eggNOG" id="ENOG502S8RP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023246_0_0_1"/>
    <dbReference type="OMA" id="GDYRGWI"/>
    <dbReference type="OrthoDB" id="337660at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="295"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="442"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="457"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="488"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS24017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="619" mass="67437" checksum="E5EBE3DF17714F1B" modified="2011-10-19" version="1">MSTPTAAALLAHRSVANIRAPSRAEESRDPSSSTTTTATTTPLRGLSAFTTPSSLRADEEIIIVELGTRKLHIGFSGDALPRGTVWFGPDQLRRVGDFREWQAGYRYDWRSETAGGRWGRDYELWRFDVRGVDLGLVGDRVERALREGFTKYMLIDSRPRRMIFVLPSGLPIPLLSAALDSVFTRFQPPTISLLSSPLAITVGAGVRSALVVDLGWSETVVTAVYEYREVSSRRSIRGGRMLVENTHRLLASYLPEPLKRPSLGQDHVLSFEECSDVTNRMVWCRPRPGAAGAAAAAAAAEQQVTQTPSSSSSVLPTVPEHEEPPQVQEPTPSAEEPTIINIPLTSCARPVTVSIPFDAFSDPCEETFFDSQYAPASFDDHELPIPLLVYRSLLQLPLDVRAVCMARIIFTGGCANVLGLRGRIFDEVSHLVRERGWDPVQGRGVEQYKKNTKLKRGPPVGQPPRQGTPEQQTQPQIQITTPSGGSRESGEGESGERGQEQDGIWQDSPARDAPQIDPIDEQLKRQADKTPKPVQGQLRAIESVGAWSGASLITHFKAPALAVVEKDQWLQHGVAGASKPGEVEHQVMSKSTSSHRQSLGGGLGRGSGGAWTLGIWGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYY6</accession>
    <name>G0RYY6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0001030</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690656.1">
        <property type="nucleotide sequence ID" value="XM_006690593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYY6"/>
    <dbReference type="STRING" id="759272.G0RYY6"/>
    <dbReference type="GeneID" id="18254141"/>
    <dbReference type="KEGG" id="cthr:CTHT_0001030"/>
    <dbReference type="eggNOG" id="KOG0907">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_1_0_1"/>
    <dbReference type="OMA" id="FQTKGRT"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="179"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS23414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="211" mass="22781" checksum="9431B3E8E7B5F123" modified="2011-10-19" version="1">MATYITSSHEFSRILTSHTVVIADFYADWCGPCQRISPIFDSLAKQHSKPSRLAFVKINVDTHQDIAQQYGVRAMPTFKIINKGGVVETIQGANPPELTAAVERAVRLAGAGKGAAFAGEGRRLGGSPIVPRSGGRGGGARSWDLMALLEVVLRFVGLYFWTLFSLDPYKAAENSPFNVNRKTNTQAGNTGATKRPAGRPAFKTLADLKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZA5</accession>
    <name>G0RZA5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0002270</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690775.1">
        <property type="nucleotide sequence ID" value="XM_006690712.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0RZA5"/>
    <dbReference type="GeneID" id="18254265"/>
    <dbReference type="KEGG" id="cthr:CTHT_0002270"/>
    <dbReference type="eggNOG" id="KOG1012">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002125_2_0_1"/>
    <dbReference type="OMA" id="WDSDRNT"/>
    <dbReference type="OrthoDB" id="419768at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04041">
        <property type="entry name" value="C2A_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04052">
        <property type="entry name" value="C2B_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21676">
        <property type="entry name" value="SMP_Mug190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057349">
        <property type="entry name" value="C2_Mug190_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037767">
        <property type="entry name" value="C2A_Mug190-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037765">
        <property type="entry name" value="C2B_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348:SF3">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25331">
        <property type="entry name" value="C2_Mug190_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25669">
        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SMP-LTD" evidence="13">
        <location>
            <begin position="375"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="602"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="791"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="35"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="764"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="999"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1193"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="84"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="773"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1001"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1199"/>
            <end position="1219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS23533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1309" mass="146783" checksum="DA681A02228C6AE8" modified="2011-10-19" version="1">MTTDERIYPSGKTHYSGTNRVPTIREFLDRLDRLKPARDAQLEEEQVEGEKAQAQGQAQAQQHHQKHPEHQEQREWLPETEGEVFVKEDKGKGKGKGKEGKEKEKEKEVIGGGEEEQKEHTIGVQTHTQGQGREDGYDWIHRAPSSASQIKQKLVGGKSKANQHGESGSKEDVTPIPPVRPPSDPNKPGKNRRIVRDPVTRQDVEIADVTGREMRQADEPKITVPLHALNPSSSPSLVDDDDDDDDDETQFLYQIISPSQPQPPSKTSFPSTTTTEIPLHHTPPTNVLFHPTPTITFSTREFESLTRRSTALCLITFLSLTILSITSSRPFAHLLLAVLITSLIYFFTKNVIKRGLQGEWHAEARRGRTALLSHVPESAEWLNALLKTVWTTLDAERVFSGVGDTLEDVMQASVPRVVEHVKVKDLSQGKEPIRVVSIRALANGEVGELKKTRQKEVRDPEEVKAEEEGGGFYNLEMTVAYHARETTSTSGGWEGKVRENVGMQIVFYLGVKGLFGVPVPIWVELRRLVATLRLRVALAPCPPFVRTVSFTLMGQPKVEASCVPLVRQGTNILELPLVAEFVNWAIATAADMYVAPRSMTIDVGKLLQGDDIKKDTNALGVLYVRIRKATGLSKQDRRGSKGGGSDPYVVVSFSKFSKPLYCTRVIEDDLNPIFEESCGLTVTAEVIKADEQLSMELWDSDRSSADDLVGKVEVSIQELMQQPGKMIQHVSKLRGIKAGSTMPGLLHWEVGYFTKAPFRRAMRTNGLDPTLPEELRSKPELQDEHGSIDDEEEDAVVHTPPDPLWRSGVLSVVVHRIVGLEFENVKGSHWSWRRRHEEDYDPARPEAGEAKEEQSGRLPNAYCTILINDELVYKTRVKAVSSRPIFEAGTERFVRDWRCCIVTVTVRDARNRQHDPIIGVVSMRLGDVLRTSSQSTRWYPLDGGIGFGRVRISLLFRSIAIRLPPSQIGFGEVGTWEFLCDSITTTDYAPSERTKLKLRTGGSSATIPSSSCSRREGDPPISGLSWSLNPPSIIRLPIRARYRSPIVFAFHPPGKRHRTDVYATLWLCDIPDWEEREITLPIWRCSNAKRLTQNYITESNLSTVPDLEVTEVGRVHFKGRFKPGTDRDHIRFVRDNDSRETIETWEACFAEGVRGEEVEGEVPGLVRELYEESLVQGRDVLALAGEGERRRWFGRREGDEEGSDSSEGETGEGDDEDGSEGSHEKKYTCSAESSTGPIAAYKAYKERSRDLNRRHRGLMQWKAMRNIQFAKDEAVFAAKKLMKVGSLSGRKPDVETEVQKALDNIVKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZD5</accession>
    <name>G0RZD5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2293 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0002580</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690805.1">
        <property type="nucleotide sequence ID" value="XM_006690742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZD5"/>
    <dbReference type="STRING" id="759272.G0RZD5"/>
    <dbReference type="GeneID" id="18254296"/>
    <dbReference type="KEGG" id="cthr:CTHT_0002580"/>
    <dbReference type="eggNOG" id="ENOG502SQ7Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006657_0_0_1"/>
    <dbReference type="OrthoDB" id="5288828at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018744">
        <property type="entry name" value="DUF2293"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38113">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38113:SF1">
        <property type="entry name" value="DUF2293 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10056">
        <property type="entry name" value="DUF2293"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2293" evidence="2">
        <location>
            <begin position="201"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="829"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="835"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="854"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="870" mass="98717" checksum="E7CD4C6534A5FCC6" modified="2011-10-19" version="1">MARERKTKHGPAAGDHAKQRHKRDRKGNLVDWRAPLPPGINALPEKPSVKLRHTTYYEVVDNKDKKKKLEMEFTEQIEPPPGFEFVPIGNPALTTACKEISRDQGAMVFIVVVNRPGFSNRLSKHLNRVGYHVRESIVEQARASLRPEQLLPLSSAPDQPEPIPEDQDEIFKQADAAIKDLFPRIPNFDREAILDQSFNKVTVLAHIRHNHTRYDELLQETSYVIARKAVENLCLETLAKWRGDEETGRDQLDEILREVIVISDSEDEESDESAEFQDENEGHEESSAATSAAEPFARIADRAEGPRRVPPLAESSSVLSITDRSRADNVHSSHAPQKVIKSSNREKEGGWAQRNLAHQARRDQVWVKALERQRRMDQGLADSVGYVPTEKLSSQRPQLWRTEPGQADSRTAAVRTLAQLPPQTDSLPVRASRPVDAYYRRDDHPEELRQVPPTHYRIPPEDCVQENHFPCVRNSVGQDFVRVSHQGQDLKDYLVPSIELPSPEFPTVEGRAALPIREREPYHVQSLWDSRRIEDHPHGGTVPPRETQKTASIYAALETQGFIELKPHSETSQTVHLGSRLDQISQRNPEPVSNARVSSSGSVRTMDSRNPRGRSYVEPLYPSGSGLVYGPSSHSTWARKDGALLRSEDYVIDADNDRLRRPDVIPAHVSSEIHGRSTGGADNRGAIRVGPCERQLTQRLDQQFLDLARNGFIQIAKSSDQFPKQHDHRSVEQTLPEYESHPVLIQHRAQRENRFTPDIYRHPSVHLQWEPAWFVDPGRQGRHHGQGSDHAFSPLPNDFQRQERVVGIEYVQQPSISTRAYPQHHTVFDVHGEQYPPPPRPHPSGPQLAASHQPHSERPVPRNHKIIEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2023-02-22" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZJ4</accession>
    <name>G0RZJ4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0003170</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690864.1">
        <property type="nucleotide sequence ID" value="XM_006690801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZJ4"/>
    <dbReference type="GeneID" id="18254355"/>
    <dbReference type="KEGG" id="cthr:CTHT_0003170"/>
    <dbReference type="HOGENOM" id="CLU_2426821_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS23622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="91" mass="9748" checksum="1E5B7DDC3E0167B7" modified="2011-10-19" version="1">MVAGVLGDVLAAVQQHNTAFPVTGHWAMARSGAVLSVRVEARQVKAKVKAEVKAEVRAKMMKLLQSRELRPGYLDRGWGAGPGGVDAIKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZL4</accession>
    <name>G0RZL4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CCAAT-binding factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0003370</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="9 10 11" key="2">
        <citation type="journal article" date="2019" name="Mol. Cell" volume="75" first="1256" last="1269.e7">
            <title>Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration.</title>
            <authorList>
                <person name="Cheng J."/>
                <person name="Bassler J."/>
                <person name="Fischer P."/>
                <person name="Lau B."/>
                <person name="Kellner N."/>
                <person name="Kunze R."/>
                <person name="Griesel S."/>
                <person name="Kallas M."/>
                <person name="Berninghausen O."/>
                <person name="Strauss D."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="31378463"/>
            <dbReference type="DOI" id="10.1016/j.molcel.2019.06.032"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.50 ANGSTROMS)</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690884.1">
        <property type="nucleotide sequence ID" value="XM_006690821.1"/>
    </dbReference>
    <dbReference type="PDB" id="6RXT">
        <property type="method" value="EM"/>
        <property type="resolution" value="7.00 A"/>
        <property type="chains" value="US=1-549"/>
    </dbReference>
    <dbReference type="PDB" id="6RXU">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.50 A"/>
        <property type="chains" value="US=1-549"/>
    </dbReference>
    <dbReference type="PDB" id="6RXV">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.00 A"/>
        <property type="chains" value="US=1-549"/>
    </dbReference>
    <dbReference type="PDB" id="6RXX">
        <property type="method" value="EM"/>
        <property type="resolution" value="7.10 A"/>
        <property type="chains" value="US=1-549"/>
    </dbReference>
    <dbReference type="PDB" id="6RXY">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.70 A"/>
        <property type="chains" value="US=1-549"/>
    </dbReference>
    <dbReference type="PDB" id="6RXZ">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.40 A"/>
        <property type="chains" value="US=1-549"/>
    </dbReference>
    <dbReference type="PDBsum" id="6RXT"/>
    <dbReference type="PDBsum" id="6RXU"/>
    <dbReference type="PDBsum" id="6RXV"/>
    <dbReference type="PDBsum" id="6RXX"/>
    <dbReference type="PDBsum" id="6RXY"/>
    <dbReference type="PDBsum" id="6RXZ"/>
    <dbReference type="AlphaFoldDB" id="G0RZL4"/>
    <dbReference type="EMDB" id="EMD-10051"/>
    <dbReference type="EMDB" id="EMD-10052"/>
    <dbReference type="EMDB" id="EMD-10053"/>
    <dbReference type="EMDB" id="EMD-10054"/>
    <dbReference type="EMDB" id="EMD-10055"/>
    <dbReference type="EMDB" id="EMD-10056"/>
    <dbReference type="SMR" id="G0RZL4"/>
    <dbReference type="STRING" id="759272.G0RZL4"/>
    <dbReference type="GeneID" id="18254375"/>
    <dbReference type="KEGG" id="cthr:CTHT_0003370"/>
    <dbReference type="eggNOG" id="KOG2154">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015945_1_0_1"/>
    <dbReference type="OMA" id="YYNNIVT"/>
    <dbReference type="OrthoDB" id="10263185at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027193">
        <property type="entry name" value="Noc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455:SF0">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9 10 11" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="6">
        <location>
            <begin position="318"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS23642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="6RXT"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="6RXU"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="6RXV"/>
        </source>
    </evidence>
    <sequence length="549" mass="63239" checksum="A5D717F6CC98597C" modified="2011-10-19" version="1">MPSAVETVTKASTKRKRQENEDEGKKRRKSISNGDSEAQKQHIKNLEEQIAESKKHYNNIANLIELAQKHDEDPKWSLAAAEALCRVFVRLLAAGSLVKRKDISEKDATIINWLRDRLSDYDGVLLSMLQSKKLAVHALVLAMAVLKAQAQHLTDREEAIFPRSFFLEIIAVVLESPIEHLRGHFSENFVKKYDDIRFYTFEAIKHFLTEREQSVDEDVRNNVFNLLLSIEDVPESNDSLENFFIERPPKKKHPLLSLSQHKKQAQEAWLAFMHLGLSKEQRKKVLEVMSASIAPWFTKPEMLMDFLTDCYNSGGSVSLLALSGVFYLIQERNLDYPEFYTKLYSLLDADILHSKYRSRFFRLLDTFLASTHLPAVLVASFIKRLARLALNAPPSAIVVIVPWFYNLFKKHPLTTFMMHRVPRTKEEREKLEKDGLDDPFLPNETDPMETRAIDSCLWEIVQLQSHYHPNVATICKIISEQFTKQAYNLEDFLDHSYGSLLEAEMTKEVKKPPVIEFMIPKHIFTKAAPEEEKKDSLLVSLWDFGSGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZV8</accession>
    <name>G0RZV8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0004380</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690978.1">
        <property type="nucleotide sequence ID" value="XM_006690915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZV8"/>
    <dbReference type="GeneID" id="18254476"/>
    <dbReference type="KEGG" id="cthr:CTHT_0004380"/>
    <dbReference type="HOGENOM" id="CLU_1677671_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="157" mass="17684" checksum="7F94367DCF17F4E9" modified="2011-10-19" version="1">MDKRKGAPTVKRAFTSQPQSFRQRMRRQQCDESSDQTAADTQATRRSIGWEEDRRDAFRRVRSRAGKPVNGVVFGRCKRDDEVLTSRMRLCTPKIWGKRPSSGGWGRGRFTHLELAFWGGLVSHLTHPTRAAAKHSSTASSTDTAGRGSLLVPLDYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0S029</accession>
    <name>G0S029_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0008530</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>oxaloacetate + acetyl-CoA + H2O = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>propanoyl-CoA + oxaloacetate + H2O = (2S,3S)-2-methylcitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23780"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:58853"/>
            <dbReference type="EC" id="2.3.3.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691381.1">
        <property type="nucleotide sequence ID" value="XM_006691318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S029"/>
    <dbReference type="STRING" id="759272.G0S029"/>
    <dbReference type="GeneID" id="18254891"/>
    <dbReference type="KEGG" id="cthr:CTHT_0008530"/>
    <dbReference type="eggNOG" id="KOG2617">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022049_2_1_1"/>
    <dbReference type="OMA" id="VLEWLFK"/>
    <dbReference type="OrthoDB" id="8017587at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050440">
        <property type="term" value="F:2-methylcitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006101">
        <property type="term" value="P:citrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06105">
        <property type="entry name" value="ScCit1-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.580.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010109">
        <property type="entry name" value="Citrate_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01793">
        <property type="entry name" value="cit_synth_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007128">
        <property type="entry name" value="PRK09569.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF8">
        <property type="entry name" value="CITRATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR610109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS23190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="473" mass="52578" checksum="50D9F5E2FAE9FE59" modified="2011-10-19" version="1">MAPAMRLATAGLRASLRAPSLVSRNAAFTAARCYSSKSQQTLKERFAELLPEKIEQIKQLRKEHGSKVVDQVTLDQVYGGARGVKCLVWEGSVLDAEEGIRFRGLTIPECQKLLPKAPGGNEPLPEGLFWLLLTGEVPTEQQVRELSADWAARAEIPKFVEELIDRCPTDLHPMAQFSMAVTALEQTSAFARAYAKGVHKKDYWHYTFEDSMDLIAKLPTIAARIYQNVFKGGKVPPVQKDKDYAWNFANQLGYAENPDFVELLRLYLTIHTDHEGGNVSAHTTHLVGSALSSPFLSLAAGLNGLAGPLHGLANQEVLLWLTEMKKTIGDDLSDEAITKYLWDTLNAGRVVPGYGHAVLRKTDPRYTAQREFALKHLPEDPMFKLVSQVYKIAPKVLTEHGKTKNPWPNVDAHSGVLLQYYGLTEAKYYTVLFGVSRAIGVLPQLIIDRAVGAPIERPKSFSTEKWIEICSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G0S062</accession>
    <name>G0S062_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0008870</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691414.1">
        <property type="nucleotide sequence ID" value="XM_006691351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S062"/>
    <dbReference type="GeneID" id="18254925"/>
    <dbReference type="KEGG" id="cthr:CTHT_0008870"/>
    <dbReference type="eggNOG" id="ENOG502SK1W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008952_0_0_1"/>
    <dbReference type="OMA" id="VRTWNSC"/>
    <dbReference type="OrthoDB" id="74545at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01709">
        <property type="entry name" value="RT_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37015">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37015:SF1">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS23223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="914" mass="105262" checksum="B1C906002D28002F" modified="2011-10-19" version="1">MASPASVLNKTLQNITFSKIRELEALRKSYESRKREYLAKADAAATEQDRLACLLDAVKELYPPASKDDSLSNIQRWLDQSRYDASIPESKLVSFSQQLRSKLDIQSRKLDMALLYSRLLTEWMDQPVSEPLPASVGDADDDSFELIERQRQRLSELVDKFEAVVFEPFETNEVEIRGFLDRLFPDEESQKELAKLRKTISEASEKFMAEKAPFNLESLTSCIKGLLTEDILSDEKQAILRDFLDSDVAKSEIADVLNMRFSDLKEWHWDAGEEGIRVMPRRGLNGKYRIWADDDILQMLFVQYIGIRLCNLLKPALKSFMRAIYSRNHDGHMVPSPAELERRRYYLGGLRSSSNNIEQRRRDEYFEKFFLSQLPATETSLFDGDHKYDDDSDDDRGLDAQDFNKLLSSPQKRSGIKQQLLRRLTAELLVHRLRGVTHDTRSQPGGGVAIVQTDLQWYATALPHSTVYAVMRYVGFGEDWIHFFKKYLAAPLNLDKASDDRPQKGPRIRQRGVPMAHSSEKFTGELVLFFMDLAVHRETGIFLYRLHDDIWLFGEPKSACKAWTCLQSFVKVFGLDLNKSKTGSVYLPGAGKKDTQIAQALPDGPVSIGFLTLDPETGKWTINQKLVQAHVDQLKKQLAESKSVLAWVQTWNSCIGRFFSHTFGEPAECFGREHINEVLNTYTNMLKRLFPQSDGKEGSAVEYVKRMIQDRFGVSDLPDSFIFLPEALGGLGLRNPFINLFLVRNEVDKTPEELIHEYLQQEREQYLGYKKEFDNLRANDNKALLRRLQNIYPGEELQKQKAIPEDQLHTFLSLEEFSRYRERQDTHFCRLYDRLVSVPVVEEIVLSKDVQNALLSLCKDGKWTLDAEKKWFLQLYSEELFQQFGGLSLVDKQFLPVGVLAMMRGKKVSWNMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0N9</accession>
    <name>G0S0N9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NIPSNAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0010700</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NipSnap family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691591.1">
        <property type="nucleotide sequence ID" value="XM_006691528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0N9"/>
    <dbReference type="STRING" id="759272.G0S0N9"/>
    <dbReference type="GeneID" id="18255108"/>
    <dbReference type="KEGG" id="cthr:CTHT_0010700"/>
    <dbReference type="eggNOG" id="KOG2883">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053393_0_0_1"/>
    <dbReference type="OMA" id="REKSWSV"/>
    <dbReference type="OrthoDB" id="10262843at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000004">
        <property type="entry name" value="NIPSNAP family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000037">
        <property type="entry name" value="NIPSNAP family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012577">
        <property type="entry name" value="NIPSNAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051557">
        <property type="entry name" value="NipSnap_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017">
        <property type="entry name" value="NIPSNAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017:SF17">
        <property type="entry name" value="PROTEIN NIPSNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07978">
        <property type="entry name" value="NIPSNAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIPSNAP" evidence="3">
        <location>
            <begin position="175"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="NIPSNAP" evidence="3">
        <location>
            <begin position="256"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS22599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="355" mass="40470" checksum="056F4174306E445D" modified="2011-10-19" version="1">MLSRRARAVMSVARSTPCQTRLFATTLATLTQQQHRSPSLSDIRPGEEESFNTRQNAFRAQLVEAQKQREASGLSDTTSSPTPGGLGSLSTALGSTGSVASVKEPPRKAGPLTNLIYGTKEGRELDAQLQASFSQVLARGKYVHQIEFHEVKPECVDEYVALVGSWYPRVAADPENKVHLVGSWRTEVGDCDTFVHIWEYQRYTGFHTSLNNISQHPDFPAFDRKLRSLIYRRRSSLMQEFSFWPTTPPRQLGGLFELRSYTLHPGNLLEWETHWRRGLKARREVMEGVGAWFVQIGDLNTVHHLWQFADLEERKRRREKSWEIEGWAETVHKTVPLIQDMKSRILVAMPWSPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0S122</accession>
    <name>G0S122_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Outer spore wall protein RRT8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0012070</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691724.1">
        <property type="nucleotide sequence ID" value="XM_006691661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S122"/>
    <dbReference type="GeneID" id="18255245"/>
    <dbReference type="KEGG" id="cthr:CTHT_0012070"/>
    <dbReference type="eggNOG" id="ENOG502QVX4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062645_0_0_1"/>
    <dbReference type="OMA" id="GRYFQLK"/>
    <dbReference type="OrthoDB" id="10012223at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005619">
        <property type="term" value="C:ascospore wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052786">
        <property type="entry name" value="Spore_wall_assembly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292:SF2">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="31544" checksum="59DDA328B7EFFDD6" modified="2011-10-19" version="1">MSSHISARAQQVLKEDIEQTLALAHNATKSRSYLYPFKGMLYFLTHTELWKPLRSKLIPYLTLYSGVLGSMFAVTYIPQLTLMAFVNGPFAVFTTAFLVVSESSTIVNLLARNYLLRDAIFDTFDGTLLSRNAGYLVAQGREVKTHGDVIERLGKMLRKPFTSFGINDLIRYLMYLPLNIVPVIGTVAFLFLRGRARAAHVHERYFQLKGWSISKREKWLKDHDGPYTAFGIVATVLEEVPLASILFSFTNTALWAADIEAQETSPIENIASRLLGAQGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G0S146</accession>
    <name>G0S146_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0012310</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="cthr:CTHT_0012310"/>
    <dbReference type="eggNOG" id="KOG1311">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021757_0_0_1"/>
    <dbReference type="OMA" id="VPVKYCK"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF43">
        <property type="entry name" value="PALMITOYLTRANSFERASE APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="412"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="13">
        <location>
            <begin position="367"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="122"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="286"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS22756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="592" mass="65385" checksum="A12E1B038A000B6B" modified="2011-10-19" version="1">MTGDDGFPQFPRSAFPGPPSIISSRMTDIMTEDGGEAAEAPSVAANRRSALYSDGTSRPGTARTGMTGISQRAPWGQAPSLRQGLAGKRASIAGSVGGSSVGARPGSAMSRSHVPTLTSHAFFRPMSSQKLQAQRGLGRPGTMEQRRFSQYSNGGENRNSMISGPDTQAGAQLDGQAGDGDLRPPPSRGTEFTEQEGFSHITATTSPTHGHYPASSLADSVKPLQGRRDAGKNLVLDLDGSNSKTHKTPVNIPTPIRTPRSLRSSFILPRGDAGGGNREMEGGEKLESVASTPMPPGTPKERPESKKKPNLGRNYEYFEGSTILPRNLHKFPPEEEDPDPYRLGPPTTEWVLVKSYEKNTAAMEVPTKFCKTCNIWRPPRAHHCRLCDNCVETQDHHCVWLNNCVGRRNYRYFFTFVASAAVLGLYLSGASLAQILVYQRREDISFGSSINHFRVPFAMVIYGILAAAYPAALTGYHVFLMARGETTREYLNSQKFLKKDRYRAFTQANWCKNWIVVLCRPRPPSYYQFKRRYEEGDQRLSAQKRTQGIVFGRRKRERDEGMEMQDVRGGPMEFMGPVALRDAARPVTMPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1B7</accession>
    <name>G0S1B7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF7728 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0013030</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691819.1">
        <property type="nucleotide sequence ID" value="XM_006691756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1B7"/>
    <dbReference type="GeneID" id="18255341"/>
    <dbReference type="KEGG" id="cthr:CTHT_0013030"/>
    <dbReference type="HOGENOM" id="CLU_552058_0_0_1"/>
    <dbReference type="OrthoDB" id="5409353at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056145">
        <property type="entry name" value="DUF7728"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40622">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40622:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24854">
        <property type="entry name" value="DUF7728"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408822" description="DUF7728 domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="401"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7728" evidence="4">
        <location>
            <begin position="71"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS22827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="494" mass="54557" checksum="96BC695319DFB46F" modified="2011-10-19" version="1">MKLNLLPAAAGLLAVPTSVAFLIPPDLPNKDIDLALSDAPTDAVDTIARALSDSSVNDFDLFASSVPDSYQIAVTCHGCPGKRHSKDPTEPKYGLFTFMFKIINHDNEPDSLWVDQRQIWPIDEQKHYHEFYAWYELDCSVPNLCNPASPLPEPLHTPSIGWGIKYYEREMEERSKNIKLLNLRFFIHSVDHIPVDGIPDEVSISMLQNEEGRLVIADIKAVTAGTPYDSPITEEGLQLAITSNNEGDEEGSEPATPTKPADGEFEIIVVEITESVDQQQEESGNDDTAEECTDIFCELLAYTKEQLKKLKQLKIFKGGCHGRPNDMPHHMPGPHHMPGGPGPHHMPPQSPGGFLPHHPHHHHPPPPPPPESPFADELKHDDTWHTEESWAQMVHDVAVNILVPVLIGIVAGVSVSIIGMAIGTLLVSTYRKFLSSRPRENDNESMIGPKPSAKEAVVVDEERAGLMENQDLPPAYEDAVAPAPAYEVHNEEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1E9</accession>
    <name>G0S1E9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0013350</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691851.1">
        <property type="nucleotide sequence ID" value="XM_006691788.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S1E9"/>
    <dbReference type="GeneID" id="18255373"/>
    <dbReference type="KEGG" id="cthr:CTHT_0013350"/>
    <dbReference type="eggNOG" id="ENOG502QRPA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002643_0_0_1"/>
    <dbReference type="OMA" id="DETMTPR"/>
    <dbReference type="OrthoDB" id="5423926at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="903"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1015"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1104"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1164"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1457"/>
            <end position="1873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="422"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="663"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="717"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="762"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="787"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="817"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="905"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="971"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1029"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1068"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1108"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1186"/>
            <end position="1195"/>
        </location>
    </feature>
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        <location>
            <begin position="1210"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1227"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1247"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1319"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1372"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1463"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1516"/>
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        </location>
    </feature>
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        <location>
            <begin position="1543"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1587"/>
            <end position="1609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1623"/>
            <end position="1640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1645"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1655"/>
            <end position="1674"/>
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    </feature>
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        <location>
            <begin position="1680"/>
            <end position="1706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1707"/>
            <end position="1735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1745"/>
            <end position="1759"/>
        </location>
    </feature>
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        <location>
            <begin position="1760"/>
            <end position="1769"/>
        </location>
    </feature>
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        <location>
            <begin position="1789"/>
            <end position="1808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1815"/>
            <end position="1824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1888" mass="200066" checksum="97A2AAC7507C6A83" modified="2011-10-19" version="1">MFGSRRHHHHQRASNPPLTLPSTTTITTTTITSTTPNTIPQPADAAAQAAAAAVFRRHDSNTSLSAAAAAAALRARPMTPTNVAEVQTKRTLRRSASIASSRSGDGGSITGGGGTGLRRRGSNASMTERTFRTPSPRPVNMGSGRSSPRIPGGLFGGVAEEAPPPVPSLPKGFVGEGDERVPQQQQQQQRPQHRKTVSLGVNATPLRLASQTLASGEGPAWFGAAKVGDMRNMRRIDPAMASPPSSPPRIGEDQNARPSSQSSSINFSYPTRTKLSSPPLTNSCTSNAGAANAFGLSQAPMSVVNPIQAPMRTSLSQTFDNRPASNGSQVSQTAQATTVSASSQSIPTLDDQVLVYDPNSRRMVPQSELRALQQELEQIGAAQQPITKRKKKARKEGSVLAAGTLRRSRIDAAHSPKGSTESVVSQQSQLSQPAEIPAQDPGVVASVQVPTATSVIITQVDQHTQPIVETSPAPPPVVVPVQPTVPLEMPRPMVRRLPSVVREVPEPGESEDDNNNKTETKTTSSEAIADAFDSVPRRTRVPVQGSPVTHLRRSPSRTSTASVTHPARVSQISVVATVADIEPMPVPDSEIAQVAKEEECRENSRTSQVARERTHSNSPVRHAHFSTAVQEHNPTIRHSPPPRSTSPRKSALKNSTSSPRGMSPAGGADGSEASGSVTHDIAAAPATRKKSVRVSFDDETTMPGKDEEHHESKSRSDSSSAPSSRHSWLGHFARRSNKDLSALDADEGVMGPRPALPSFGSVRDKKPRDTSTVEEERPLVVKPKIQSKPSHQGRSSGPSVVLGMSGDHVIGGVIAAQEQPQQLPQPSRNEANTSKVREPLPPIVTSREGDGFLSDTSSLLDSEYEPTPISPKKEFAVVKEGGLLGAANGSAVPADSLSAVEVVRDQQQSSSEGEARLTTNPLVFAKETEARSPQLKDLPGGFPDSESEPASSVAGSMWPVEESVAEEKLKNNTPQETMTQADDESSSDAESIYADAYETLANVDGAGFQSIDAVVERPMGTKEPAGLQDGTSTQCASSQATAQIQKPAGTSAETPSQKPVEQALKLQTDVSSATTAVGTPSSLTSPQEEWERLKAFWKSLTPEQRAQFARELEEDRPDGNDDTNGANGKKAEPSTTPTTHKKATQKSVVWDDLERRARAVELAQQMMAQQAKEKEIASSQPVEEPAASASTSTSTIKRTLRDAQPAPAQASGTKLRSSLRTNGSSKVEATAPAAVAPEPATNHRRSATQPEPSFDVSTQSIVPLQRRGSTGSDSSFKRSRPNKSYGLGFRHSLRENSPALAEQAQAQADRPFKRLSLRGAPPAGSPGASPMQKVEEQLAPGQMRKTLRDNSRPPPARSASFSAGEKKKPRGKSPLGLRLPSLPGLSYGGKKSQSSSVKASGPKKFASRFADSSDDEDDGVQSGFRSRFEDSSDDEPLPNAVPVLSGAARAAGIAAMAGADAPNRSQTGSVASTALPEELEESDSSVKEERQPPPAAVSSPSSVKKLDRSLRRSRSGRGQLPAPDRPSTPSAATATTIPSAESVDTTPTKRSPGTTKKRRNSLISVLRPLHLQRKKHDSSVDGAGKIVRPEVIESPARRDTRLERDVRELRRIRRGSSESQIREEEEGEGEQEEVSTEVEEAVSGKKGKLQKRIKRGESVRERGRGSGKGKEKEVQGAVSGENAGPAGAENAAPTLSVQDEPQQPLDQPQPQPQPEPQPEPQPEPQQQPPPEPPSPSIFRPLFKRTGTSSSIPSGPAASSANLGTRTLATNPPPTRPSHTGGSLRLPRFSHSTSSQHPPQQVQQRRVSSLVLPSFSGHNNNTGSAVPSAAASDAGSFMGPIPDVGRSNTDVATGGVSGAGSIAGTVSSSGGGERKKRFGKLRRMFRLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1I3</accession>
    <name>G0S1I3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0013700</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691885.1">
        <property type="nucleotide sequence ID" value="XM_006691822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1I3"/>
    <dbReference type="GeneID" id="18255408"/>
    <dbReference type="KEGG" id="cthr:CTHT_0013700"/>
    <dbReference type="HOGENOM" id="CLU_550936_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025040">
        <property type="entry name" value="DUF3984"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13136">
        <property type="entry name" value="DUF3984"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="495" mass="56190" checksum="2FD9A195B812AF91" modified="2011-10-19" version="1">MELASTSSMSSSAPNSPAPRRPNRANRNINNLNLNPLTPILPEEHKQRHANRRVEDFIPPYTSSTLCRRSAPPTPGQSLFSHQPGPGENSWVRPPRRRGASAPGLQTRLVALQQYKQCPTDFYFQPGGKTRPFPQAPLSEVLERAGAWLTNTVREETGSTYLVRSAKSMTDLQEASAAISGELPLDDFRKRWWDDYERKEKERELERTNPELAKARRLEMARLQREHERAKRWLHEKRWAERRYIKHGTGTWQSLSAPLSRIGSQMSIGTGGNSETYGLPPGVLMTPGTGVITMTGDLGYEEIEKEVKEIEAEEAARDAEDEEYFRMTGQVDPRTLKALEKPLPPEAEQPPALEAVERDIRTLLRRQRNGITGGWFGKMLGIRSYRLSGDTEEDKLKEGDFDEQDYWEAGQHESGVYYFGNEDLSSDDHRPLDEWGNPLTSPRYLPVPGSLVWIDAQYEAADMEEAGLIEPAPEQATWVEDMAWLFRLAKSLLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1N7</accession>
    <name>G0S1N7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BTB/POZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0014260</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691939.1">
        <property type="nucleotide sequence ID" value="XM_006691876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1N7"/>
    <dbReference type="STRING" id="759272.G0S1N7"/>
    <dbReference type="GeneID" id="18255464"/>
    <dbReference type="KEGG" id="cthr:CTHT_0014260"/>
    <dbReference type="eggNOG" id="KOG0511">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022885_2_0_1"/>
    <dbReference type="OMA" id="EGARCIY"/>
    <dbReference type="OrthoDB" id="684045at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18497">
        <property type="entry name" value="BACK_ABTB1_BPOZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000248">
        <property type="entry name" value="Ankyrin repeat and BTB/POZ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000183">
        <property type="entry name" value="Ankyrin repeat and BTB/POZ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044515">
        <property type="entry name" value="ABTB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46231">
        <property type="entry name" value="ANKYRIN REPEAT AND BTB/POZ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46231:SF1">
        <property type="entry name" value="ANKYRIN REPEAT AND BTB_POZ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="6">
        <location>
            <begin position="148"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="6">
        <location>
            <begin position="363"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="313"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="313"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="330"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS22947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="635" mass="72224" checksum="447CB493E1A78C57" modified="2011-10-19" version="1">MSFRKFELENKLKEDNNLIRAGVLRNDHPLDTSREFQDFLQACRRGDLKYCQEAISNGININARDQFDYTPLVIASLCGHYELVQLLLESGVIADPGSFERERAVYNALNDKIRNLLLSYDYSKSSDPLQPWSSHITSLLVRDSPHTSDIVLTLSNEHFSLHKFILCARSPYFMRKLSETPETTTWKVSPSIPVEALRIVLRYLYLGELPRDLVPPRSAVSEEEVFSGIDKLCRQLELEKLWEEVLSINDRRLARQRHQDEVQRAQAQIEAFFNETVLKHKMIVDTAEVADVKWPHHNAIFANCLLRADEPLPPEEEEEEKDNDDHDQESSIPVNGTTIPIGPTSSHRIFNGTSKRIRRSVLFPAHKAFLIRSPYFETMFASDFREAYDTATLHVITVDCTPPVLEIILRFLYTEKFSCPLEHALDLLYTADMLLLEQLKTKAAATISTLGSGNSNVLVDRTHLNQACAPKSKGSNTSEPEPEPINVYDVIHAAWDLKIQRLEEFAARYLASRLEDYVETDEFAELIRESAARLKSERHETDTIELLDDIRYYLGERFRLRFEGGGIGELLAGGLEEGEGERGQRKTNAETGGDLGGVRALNGQVVEDEFASDAVNYHVLMEKIDKMLEKLNLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1P5</accession>
    <name>G0S1P5_CHATD</name>
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        <submittedName>
            <fullName evidence="5">Pantothenate kinase-like protein</fullName>
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        <name type="synonym">Thermochaetoides thermophila</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
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        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
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                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="4'-PHOSPHOPANTETHEINE PHOSPHATASE"/>
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    </dbReference>
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        <property type="entry name" value="PANTOTHENATE KINASE"/>
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    </dbReference>
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    </dbReference>
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            <begin position="1"/>
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            <begin position="23"/>
            <end position="41"/>
        </location>
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            <end position="552"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
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            <dbReference type="EMBL" id="EGS22955.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
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</entry>
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    <accession>G0S1R0</accession>
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    <reference evidence="5 6" key="1">
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            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
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                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
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            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="476" last="476">
            <title>High-resolution structures of a thermophilic eukaryotic 80S ribosome reveal atomistic details of translocation.</title>
            <authorList>
                <person name="Kisonaite M."/>
                <person name="Wild K."/>
                <person name="Lapouge K."/>
                <person name="Ruppert T."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="35079002"/>
            <dbReference type="DOI" id="10.1038/s41467-022-27967-9"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.90 ANGSTROMS)</scope>
    </reference>
    <reference evidence="11 12 13" key="3">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e56910" last="e56910">
            <title>Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation during pre-60S biogenesis.</title>
            <authorList>
                <person name="Lau B."/>
                <person name="Huang Z."/>
                <person name="Kellner N."/>
                <person name="Niu S."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
                <person name="Cheng J."/>
            </authorList>
            <dbReference type="PubMed" id="37129998"/>
            <dbReference type="DOI" id="10.15252/embr.202356910"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <reference evidence="15 16 17" key="4">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e57984" last="e57984">
            <title>Structural insights into coordinating 5S RNP rotation with ITS2 pre-RNA processing during ribosome formation.</title>
            <authorList>
                <person name="Thoms M."/>
                <person name="Lau B."/>
                <person name="Cheng J."/>
                <person name="Fromm L."/>
                <person name="Denk T."/>
                <person name="Kellner N."/>
                <person name="Flemming D."/>
                <person name="Fischer P."/>
                <person name="Falquet L."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="37921038"/>
            <dbReference type="DOI" id="10.15252/embr.202357984"/>
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        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.12 ANGSTROMS)</scope>
    </reference>
    <reference evidence="9 10" key="5">
        <citation type="journal article" date="2023" name="Nat. Struct. Mol. Biol." volume="30" first="670" last="677">
            <title>Structural inventory of cotranslational protein folding by the eukaryotic RAC complex.</title>
            <authorList>
                <person name="Kisonaite M."/>
                <person name="Wild K."/>
                <person name="Lapouge K."/>
                <person name="Gese G.V."/>
                <person name="Kellner N."/>
                <person name="Hurt E."/>
                <person name="Sinning I."/>
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            <dbReference type="DOI" id="10.1038/s41594-023-00973-1"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.20 ANGSTROMS)</scope>
    </reference>
    <reference evidence="14" key="6">
        <citation type="journal article" date="2024" name="Nat. Commun." volume="15" first="716" last="716">
            <title>Methionine aminopeptidase 2 and its autoproteolysis product have different binding sites on the ribosome.</title>
            <authorList>
                <person name="Klein M.A."/>
                <person name="Wild K."/>
                <person name="Kisonaite M."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="38267453"/>
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        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.10 ANGSTROMS)</scope>
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    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL14 family.</text>
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    <dbReference type="EMDB" id="EMD-17953"/>
    <dbReference type="EMDB" id="EMD-17954"/>
    <dbReference type="EMDB" id="EMD-17955"/>
    <dbReference type="EMDB" id="EMD-17956"/>
    <dbReference type="EMDB" id="EMD-17957"/>
    <dbReference type="EMDB" id="EMD-17969"/>
    <dbReference type="EMDB" id="EMD-17970"/>
    <dbReference type="EMDB" id="EMD-35279"/>
    <dbReference type="EMDB" id="EMD-35281"/>
    <dbReference type="EMDB" id="EMD-35283"/>
    <dbReference type="EMDB" id="EMD-35285"/>
    <dbReference type="EMDB" id="EMD-35286"/>
    <dbReference type="EMDB" id="EMD-35287"/>
    <dbReference type="EMDB" id="EMD-35288"/>
    <dbReference type="EMDB" id="EMD-35289"/>
    <dbReference type="EMDB" id="EMD-35290"/>
    <dbReference type="SMR" id="G0S1R0"/>
    <dbReference type="STRING" id="759272.G0S1R0"/>
    <dbReference type="GeneID" id="18255487"/>
    <dbReference type="KEGG" id="cthr:CTHT_0014490"/>
    <dbReference type="eggNOG" id="KOG3421">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082438_3_0_1"/>
    <dbReference type="OMA" id="KLCFVVD"/>
    <dbReference type="OrthoDB" id="1875589at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23702">
        <property type="entry name" value="eL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039660">
        <property type="entry name" value="Ribosomal_eL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002784">
        <property type="entry name" value="Ribosomal_eL14_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01929">
        <property type="entry name" value="Ribosomal_L14e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7 8 9" id="KW-0002">3D-structure</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL14" evidence="4">
        <location>
            <begin position="53"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS22970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="7OLC"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="7OLD"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="7Z3N"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="7Z3O"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="8I9P"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="8I9R"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="8I9T"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="8OO0"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="8PV1"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="8PV2"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PDB" id="8PV3"/>
        </source>
    </evidence>
    <sequence length="142" mass="16080" checksum="D1F15720B755EBD6" modified="2011-10-19" version="1">MAEINVEATSWRRVEVGRVLKLENGSLAAIVEIIDHKRVLADGPSSDPKLATPRGIVPLSRALLTPIVIPKLPRGARTGAVKKAWEAYGVDAKWKETNWAKKQLQQERRQSLTDFDRFKVMRLKKQRRFEERKALAKIKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1V3</accession>
    <name>G0S1V3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="6">PPIase</shortName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0014950</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="10 11 12" key="2">
        <citation type="journal article" date="2025" name="Cell Res." volume="35" first="296" last="308">
            <title>Structural insights into spliceosome fidelity: DHX35-GPATCH1- mediated rejection of aberrant splicing substrates.</title>
            <authorList>
                <person name="Li Y."/>
                <person name="Fischer P."/>
                <person name="Wang M."/>
                <person name="Zhou Q."/>
                <person name="Song A."/>
                <person name="Yuan R."/>
                <person name="Meng W."/>
                <person name="Chen F.X."/>
                <person name="Luhrmann R."/>
                <person name="Lau B."/>
                <person name="Hurt E."/>
                <person name="Cheng J."/>
            </authorList>
            <dbReference type="PubMed" id="40016598"/>
            <dbReference type="DOI" id="10.1038/s41422-025-01084-w"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.80 ANGSTROMS)</scope>
    </reference>
    <comment type="function">
        <text evidence="2 6">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS23013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692005.1">
        <property type="nucleotide sequence ID" value="XM_006691942.1"/>
    </dbReference>
    <dbReference type="PDB" id="9L5R">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="S=1-167"/>
    </dbReference>
    <dbReference type="PDB" id="9L5S">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="S=1-167"/>
    </dbReference>
    <dbReference type="PDB" id="9L5T">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.50 A"/>
        <property type="chains" value="S=1-167"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1V3"/>
    <dbReference type="EMDB" id="EMD-62841"/>
    <dbReference type="EMDB" id="EMD-62842"/>
    <dbReference type="EMDB" id="EMD-62843"/>
    <dbReference type="SMR" id="G0S1V3"/>
    <dbReference type="STRING" id="759272.G0S1V3"/>
    <dbReference type="GeneID" id="18255533"/>
    <dbReference type="KEGG" id="cthr:CTHT_0014950"/>
    <dbReference type="eggNOG" id="KOG0881">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_16_3_1"/>
    <dbReference type="OMA" id="ELYNDHA"/>
    <dbReference type="OrthoDB" id="271386at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000008">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="10 11 12" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="7">
        <location>
            <begin position="8"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS23013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="9L5R"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="9L5S"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="9L5T"/>
        </source>
    </evidence>
    <sequence length="167" mass="18338" checksum="3927150CE0D5B323" modified="2011-10-19" version="1">MATDVALETTMGTIILELYNQHAPRTCENFKTLAARGYYDGTIFHRVIKDFMVQGGDPTGTGRGGRSIYGDTFEDEIHPGLRHTGAGILSMANAGPNTNGSQFFLTLAPTPWLDGKHTIFGRVKKGIRVLQRMGLVPTDADDRPKTEIKIIRAYVVGEGEEDDKQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1Z2</accession>
    <name>G0S1Z2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphatidylinositol N-acetylglucosaminyltransferase GPI3 subunit</fullName>
            <ecNumber evidence="3">2.4.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GlcNAc-PI synthesis protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0015370</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalytic subunit in the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.198" evidence="3"/>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS23052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692044.1">
        <property type="nucleotide sequence ID" value="XM_006691981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1Z2"/>
    <dbReference type="STRING" id="759272.G0S1Z2"/>
    <dbReference type="GeneID" id="18255575"/>
    <dbReference type="KEGG" id="cthr:CTHT_0015370"/>
    <dbReference type="eggNOG" id="KOG1111">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_19_2_1"/>
    <dbReference type="OMA" id="SHFWMSG"/>
    <dbReference type="OrthoDB" id="734129at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017176">
        <property type="term" value="F:phosphatidylinositol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03796">
        <property type="entry name" value="GT4_PIG-A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000053">
        <property type="entry name" value="Phosphatidylinositol N-acetylglucosaminyltransferase GPI3 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000026">
        <property type="entry name" value="Phosphatidylinositol N-acetylglucosaminyltransferase subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039507">
        <property type="entry name" value="PIG-A/GPI3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013234">
        <property type="entry name" value="PIGA_GPI_anchor_biosynthesis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08288">
        <property type="entry name" value="PIGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="PIGA GPI anchor biosynthesis" evidence="11">
        <location>
            <begin position="48"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="10">
        <location>
            <begin position="217"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS23052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="486" mass="54677" checksum="10D98C7551616598" modified="2011-10-19" version="1">MTPRSRPTYNIAMVSDFFFPQPGGVESHIYQLSTKLRDRGHKVIIITHAYEGRTGVRYLTNGIKVYHVPFLVVYRSASFPTVFSFFPIFRNIVLREKIDIVHGHASLSSLCHEAILHARTMGLRTVYTDHSLFGFADAASIFANKLLKFSLSDVDHVICVSHTCKENTVLRASLDPLMVSVIPNAVVAENFRPLEDSEVQNGMFKGHPAPVRPPGPDDMITIVVISRLFYNKGTDLLTAAIPRILENHPNTRFIIAGDGPKAIDLEQMIEQNVLQDRVEMLGPIRHEEVRDVMVRGHIYLHPSLTEAFGTVIVEAASCGLYVVCTQVGGIPEVLPSHMTVFAKPEEDDLVEATGRAIAAIRANKVRTELFHEQVKSMYSWTNVATRTERVYDGISGAISEEEFYGYEAVDGWSATRGRSGVQSFALIDRLKRYYGCGIWAGKLFCLCVIVDYLIFLFLELWFPRDQIDICPDWPRKEPKERGKDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2B4</accession>
    <name>G0S2B4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acyl-CoA dehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0016640</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692166.1">
        <property type="nucleotide sequence ID" value="XM_006692103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2B4"/>
    <dbReference type="STRING" id="759272.G0S2B4"/>
    <dbReference type="GeneID" id="18255702"/>
    <dbReference type="KEGG" id="cthr:CTHT_0016640"/>
    <dbReference type="eggNOG" id="KOG0137">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_4_4_1"/>
    <dbReference type="OMA" id="YQCEKMG"/>
    <dbReference type="OrthoDB" id="10254877at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF28">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="7">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="79"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS22147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="543" mass="60884" checksum="0EA57CDDC477E58C" modified="2011-10-19" version="1">MSKIFTQSDVAAHSKPDSLWIVIDGDVYDLTKFQDEHPGGKKILQKVAGKDASKQFWKYHNEAILKKYQKQLQIGSLDTKPKAEEPPAPAPAPKKEAPKPKAAAAPAHGEEAEALDPFGSLIPFSDPSWYQGYHSPYYNETHAALRAEVREWIEKEIEPFVTEWDEKKQVPPEIYKEMGRRGYLAGLLGTKYQKDYVKNHVKSVPPEQWDLFHELVLTDELSRTGSGGFVWNVIGGFGIGCPPLVKFGKKSLVDRILPGILSGEKRICLAITEPDAGSDVANITCEAKLSEDGKYYIVNGEKKWITNGIWCDYFTTAVRTGGPGMDGVSLLLIERDFGGVSTRRMDCQGVWSSGTTYITFEDVKVPVENLIGKENKGFRVIMTNFNHERIGIIIQCLRFSRVCFEEAVKYANKRRTFGKKLIDHPVIRLKLAHMARQIEASYNWLENIIYQCQKMGETEAMLRLGGAIAGLKAQATVTFEFCAREASQIFGGLSYSRGGQGGKIERLYRDVRAYAIPGGSEEIMLDLSIRQSMRVHKMIGMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2K5</accession>
    <name>G0S2K5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative phosphatidylinositol transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0017550</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692257.1">
        <property type="nucleotide sequence ID" value="XM_006692194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2K5"/>
    <dbReference type="STRING" id="759272.G0S2K5"/>
    <dbReference type="GeneID" id="18255793"/>
    <dbReference type="KEGG" id="cthr:CTHT_0017550"/>
    <dbReference type="eggNOG" id="KOG1470">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016665_3_0_1"/>
    <dbReference type="OMA" id="ISTMRWR"/>
    <dbReference type="OrthoDB" id="43460at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052432">
        <property type="entry name" value="PITP/CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN CSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN CSR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="213"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="476"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="494" mass="56331" checksum="BCD9AA8F2DF8BB99" modified="2011-10-19" version="1">MATEIAPGRPGNLTPEQEEKLRKLWQYIFQVCAVGQEQSSSAENAPAAEAEKSQDADKKEKKSRMSLFSRKSKKDSDGASSSGDSSAPPGARVVLHLKDGDNDKYGQTKQFYDTLASQSPQSIRDTIWSMIKHDNPDALVLRFLRARKWDVERALIMLVSTMSWRMSEMKVDDDIMRNGEGAAWAAEKNSEDANEKKLAHDFMTQIRKGISYVHGVDKQGRPLCFVNVRLHRQGEQAEEALERYTVYLIETCRMLLQPPVDTATIVFDMTDFSLANMDYAPVKFMIKCFEANYPESLGAVLVHKAPWIFQGIWKVIRGWLDPVVANKVHFTNNAKEMEEFIPMKHIPKSLDGEEDWTYSYVEPTEDENALMRDIATRDQMLAERAKLYREYEEATLEWIRIAEEGGDQTEIKKKRDEIAERLRVDYWKIDPYLRARSYYDRIGVLQPGGRLNWYPEEKKAEQQQSQGNGAAEKVEAVVSAAAAESTTTSAQDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2P4</accession>
    <name>G0S2P4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0017980</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692296.1">
        <property type="nucleotide sequence ID" value="XM_006692233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2P4"/>
    <dbReference type="GeneID" id="18255836"/>
    <dbReference type="KEGG" id="cthr:CTHT_0017980"/>
    <dbReference type="HOGENOM" id="CLU_521753_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="522" mass="60482" checksum="6089E59433EFBEFF" modified="2011-10-19" version="1">MCKIRVVHFTLCGSTRVPMSLHPWTDTDIASWPYDASKTLIATGSCHTCECESIHLWQRYRSYIQQHYGLDDESQFVFSKHLRLCMWHRCCLVWEQRTWCPVVGRRWNALAEEWADDEFFDPGVAALFNDPLVAVPQPQPQLQPQPQSQDDSFDSDASSPPEPAWSDFSSSSELEVPDSIHLHRSHNHLEPIPEALHAWELALHRHPEHDCDNKCVLNEYRPLAELMTEKVAAEELDLISPASEAPHKCELCGHEQPRFWWGESWDLPGAQPEGNIPGVAGPEITGVRFPGEILYREDGQLAPSEFKNDNDQEGEEAAVSMSNELMMLDMTRGDFYWYSANLFTQKLSLRETMDTLRHMKDREPYIFGEDMGIILLKTYPLDILWYLRDLRVLIRQAEEKIEKVADRWVTAMYHLGSLLESLRRYPKGPGDSVRGLGGEFEVTWEMLQVGKSEDGKEAMERVMEMEGSLKNVGEYKLLYKELSEVLRVPKVLNKRWEERRKKFTLRTPKERIGYWAWKKKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2U7</accession>
    <name>G0S2U7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0018540</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692349.1">
        <property type="nucleotide sequence ID" value="XM_006692286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2U7"/>
    <dbReference type="GeneID" id="18255892"/>
    <dbReference type="KEGG" id="cthr:CTHT_0018540"/>
    <dbReference type="eggNOG" id="ENOG502RR4N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091764_0_0_1"/>
    <dbReference type="OMA" id="WGFTIMA"/>
    <dbReference type="OrthoDB" id="5199007at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS22330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="207" mass="23057" checksum="390C18AD31833A3D" modified="2011-10-19" version="1">MSTRPELDSFKCHASVEAALEPLSIVDGHLSIPTETCIFTLLSECYTKIRDIFGLNDPENVLGQPDALDSMLKVTFDTFHRSFVTEKSTHVLADLDDHEKSSLYLQAVAGMVLIFQRLKAAGPELSQRLFSRELQLFAESDQRESVLETIDTTDIINSCFAKRAVVDFISGVIEGRKKEQKTEDQSVNAAWGKNLGVPWGFTVMALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3E7</accession>
    <name>G0S3E7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0020750</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692549.1">
        <property type="nucleotide sequence ID" value="XM_006692486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3E7"/>
    <dbReference type="SMR" id="G0S3E7"/>
    <dbReference type="ESTHER" id="chatd-g0s3e7">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="18256113"/>
    <dbReference type="KEGG" id="cthr:CTHT_0020750"/>
    <dbReference type="eggNOG" id="KOG4389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_10_6_1"/>
    <dbReference type="OMA" id="NNWYPQF"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000213">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005130817" description="Carboxylic ester hydrolase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="9">
        <location>
            <begin position="33"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS22530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="576" mass="62490" checksum="350D6C734554EB6A" modified="2011-10-19" version="1">MKGFSKLLTAALIGTAAAAPPEPPTKVLAKRAAPTVTISTGTVIGTDRIVTEAFNGIPFAKAPTGNLRLRPPVRINESLGVIDATGIAPACPQFLADASSNEFLAQVLDKVTNLPFFQKALKITEDCLTVSVIRPKGVKAGDKLPVLFWIYGGGFELGWSSMYDGGPLVASATSLGKPFIFVAVNYRVAGFGFMPGKEILADGAANLGLLDQRMGLEWVADNIEAFGGDPNKVTIWGESAGSISVYNQMALYDGDNTYKGKPLFRAAIMNSGSMIPADPVDCPKGQQVYNTVVAKAGCSGAADTLACLRSLPYEKFLRAANSVPAILSYNSVALSYLPRPDGKVLTKSPDLLAKEGKFAAVPMIIGDQEDEGTLFSLFQTNVTTTDRLVTYLKDIFFHNASKKQLEDLVNTYEPWVWAGSPFRTGLLNEVYPGFKRLAAILGDLVFTLTRRIFLEYVTAAKPNVPVWSYLASYDYGTPILGTFHGSDLLQVFYGVLPNYASKSIHSYYANFIYNLNPNDASGGTSSKSKVSETWPQWTSSTRKLINFFANRNEFIKDDFRSDSAAFIRNNVNILHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3K4</accession>
    <name>G0S3K4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0021570</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692627.1">
        <property type="nucleotide sequence ID" value="XM_006692564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3K4"/>
    <dbReference type="GeneID" id="18256195"/>
    <dbReference type="KEGG" id="cthr:CTHT_0021570"/>
    <dbReference type="eggNOG" id="ENOG502QR0G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047601_0_0_1"/>
    <dbReference type="OMA" id="HQPDPKC"/>
    <dbReference type="OrthoDB" id="10248513at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000039">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.13, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF874">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="5">
        <location>
            <begin position="226"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS20331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="441" mass="49799" checksum="D01C70CC33BB63AF" modified="2011-10-19" version="1">MSPPELSMDLPVIDLDVFLNNPIDSPEVQAECKKAADALITYGALVLHDSRVSEQDNETFLDLLEDYFAQPEEVLKKDERPELSYQVGVTLENTEKPKCAVDEPCLNVIRRLAPSERPLDISGHQPDPKCRFFWRMGETAPNTQFPSLNADNIVPQAPHIKERWTPAMNKWGTSMKNAVEGLARMAAVGMGLDANTFVDAGRYGPHLLAPTASDLVKYGAKDTILAGFHTDLNFLTIHGRSRYPGLHIWARNTGKRIAVKIPAGRNYLLVQAGKQLEYLSGGLVKAGYHEVVVNERTLETIAMRKEKFPDRPLIRISSTFFWHLSSDFDLAPIPSLAAKAKEVRQKMIELGWDEGEEVSYPPIKVGEQVQNELKHIALMWWDISSMLECFLGYLKWNFIDHFGATERFAFMADCKQFKAEPGRLEKLKLNGRKIKEFTVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0S486</accession>
    <name>G0S486_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="4">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0031090</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="4"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693556.1">
        <property type="nucleotide sequence ID" value="XM_006693493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S486"/>
    <dbReference type="STRING" id="759272.G0S486"/>
    <dbReference type="GeneID" id="18257147"/>
    <dbReference type="KEGG" id="cthr:CTHT_0031090"/>
    <dbReference type="eggNOG" id="KOG2450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_1_0_1"/>
    <dbReference type="OMA" id="FPEGCFQ"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07102">
        <property type="entry name" value="ALDH_EDX86601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000009">
        <property type="entry name" value="Aldehyde dehydrogenase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000012">
        <property type="entry name" value="NAD-dependent succinate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="5"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS21260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="466" mass="51303" checksum="45BA51F63647BD3A" modified="2011-10-19" version="1">MSEIITTISPTTGEPILTRNGISQQELEQLPEIAKKAFESWRTTKLADRQAIIRKALAILDERKDELATELTVQMGRPIAYTPKEIGTAIKRAEYMMSISDEALQDTPGQAESGFKRFIRKVPVGPVLIIFAWNYPYLILVNALIPALLCGNSVILKPSPQTPTVVEQIAKAFNEAGLPHGVIQYFHSGSPAIIESIVRDPRIALVCFTGSVAGGLAVQGAASTRIVNVGLELGGKDPAYVRGDVDITWAAEEIVDGAVFNSGQSCCAIERVYVDEKIHDEFIAAIQKVLKGYRVGDPLDKKTHVGPVISKRAKETIEAHIKDALEKGAINATPENETFDDLPQKGNFVPPTLLINVDHSMRVMKDETFGPVIPVMKVKNDEEAIKLMNDSEYGLTASIWTKDTQKAYELCELVEAGTVFVNRCDYPSPDLAWTGWKNSGKGVTLSRFGFDQFVKLKSYHLKDYPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4A4</accession>
    <name>G0S4A4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0039470</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS22062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694358.1">
        <property type="nucleotide sequence ID" value="XM_006694295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4A4"/>
    <dbReference type="STRING" id="759272.G0S4A4"/>
    <dbReference type="GeneID" id="18257985"/>
    <dbReference type="KEGG" id="cthr:CTHT_0039470"/>
    <dbReference type="HOGENOM" id="CLU_125562_1_0_1"/>
    <dbReference type="OrthoDB" id="2017497at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032126">
        <property type="term" value="C:eisosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052649">
        <property type="entry name" value="NCE102-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28165:SF2">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28165">
        <property type="entry name" value="NON-CLASSICAL EXPORT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="6">
        <location>
            <begin position="11"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS22062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="211" mass="22416" checksum="C4C7212679B7305D" modified="2011-10-19" version="1">MAKLAVLGPQVLQFLLALTVLGLAAHFVRIWVIGSAPVTIRYTVFVGAFGMFVAIVGAAVLLFASESASSIVQLGPVLLDAIFAILALAAGIAWAIGLGGGLENCKHGGNMLKNNLLNQGSRGSGKNKVYGVFKGTNDEEKVYHRLQGNCRRARADEALLFISTAISLGFVVYGFLKARKASGGLVSFQLGKLGRRTYVYLEQTVLRVMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4D5</accession>
    <name>G0S4D5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Short-chain dehydrogenase/reductase 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Retinal short-chain dehydrogenase/reductase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0039790</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS22093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694389.1">
        <property type="nucleotide sequence ID" value="XM_006694326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4D5"/>
    <dbReference type="GeneID" id="18258017"/>
    <dbReference type="KEGG" id="cthr:CTHT_0039790"/>
    <dbReference type="eggNOG" id="KOG1201">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_5_2_1"/>
    <dbReference type="OMA" id="CDITTVE"/>
    <dbReference type="OrthoDB" id="10253736at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052650">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000131">
        <property type="entry name" value="Short-chain dehydrogenase/reductase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS22093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="358" mass="38972" checksum="F5393588C9A5ED1D" modified="2011-10-19" version="1">MTSRLCYFVLDAAASIGRTLLSPFVTVPVLFAVTYHLDTVSRLLSPLPQGLALISPPHQSSSLLNVLRVVVAWGILRAANRALSAIAATSWRLVPAPGWDWPNEIAVITGGSSGIGKAIAEKLSSMGVRIAVLDIQELPKDLQENPRVHFFHCDVTIFKSVAAAADAVRNQLGHPSILINNAGIAKPMTILETDEVFLRRIMGVNLMSMWFTTQQFVPYMIETNKGHVVTMASMASFISVPTAADYAATKAGALAFHETLSLELKHYHKAPNVLTTVAHPNFVKTPLIQGFADNLERKGLRLLTPEEVASDIVKQIKKRRGGQLIISKDGSYLAGIRSWPLWLQEGVRDIIASGAAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4W6</accession>
    <name>G0S4W6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CinA C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0031920</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693633.1">
        <property type="nucleotide sequence ID" value="XM_006693570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4W6"/>
    <dbReference type="GeneID" id="18257230"/>
    <dbReference type="KEGG" id="cthr:CTHT_0031920"/>
    <dbReference type="eggNOG" id="ENOG502S20M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030805_1_0_1"/>
    <dbReference type="OMA" id="FKFLNMD"/>
    <dbReference type="OrthoDB" id="2350783at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="entry name" value="CinA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008136">
        <property type="entry name" value="CinA_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00199">
        <property type="entry name" value="PncC_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02464">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="CinA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CinA C-terminal" evidence="1">
        <location>
            <begin position="12"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="175" mass="18157" checksum="8E0C3A734505AB33" modified="2011-10-19" version="1">MTPRSTETMFDIASDVINLLRKSKETLAVAESLTGGGVMMALTAVPGASECVRGGVVSYTIPLKENILGVDENLIAREGVVHASVAAQMAEGARRVAAVDGIEATWGLGTTGDAGPDKQGKDVGTVFLAVAASDDTQTWGPFSFPGSREQVRQGAILEALARLRQALVGRKANSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4W7</accession>
    <name>G0S4W7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP phosphoribosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0031930</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693634.1">
        <property type="nucleotide sequence ID" value="XM_006693571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4W7"/>
    <dbReference type="STRING" id="759272.G0S4W7"/>
    <dbReference type="GeneID" id="18257231"/>
    <dbReference type="KEGG" id="cthr:CTHT_0031930"/>
    <dbReference type="eggNOG" id="ENOG502S6WE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120084_2_1_1"/>
    <dbReference type="OMA" id="NYTECCF"/>
    <dbReference type="OrthoDB" id="15981at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41774">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41774:SF1">
        <property type="entry name" value="NGG1P INTERACTING FACTOR NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="95" mass="10080" checksum="7571FE463E5A4C25" modified="2011-10-19" version="1">MASAVARYKLVFYVPLNAVEACKKAIFAAGAGRYPGGNYTECCWTTNGTGQFRPGDAANPHIGKVGELEYVEEACVSTICFGEDVARNAVAALKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0S525</accession>
    <name>G0S525_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor Iwr1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0023830</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IWR1/SLC7A6OS family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692846.1">
        <property type="nucleotide sequence ID" value="XM_006692783.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="18256421"/>
    <dbReference type="KEGG" id="cthr:CTHT_0023830"/>
    <dbReference type="eggNOG" id="ENOG502SE90">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039754_0_0_1"/>
    <dbReference type="OMA" id="EYWEHFA"/>
    <dbReference type="OrthoDB" id="6255506at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040150">
        <property type="entry name" value="Iwr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013883">
        <property type="entry name" value="TF_Iwr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28063">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN IWR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28063:SF1">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN IWR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08574">
        <property type="entry name" value="Iwr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor Iwr1" evidence="3">
        <location>
            <begin position="343"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="383"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
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        <location>
            <begin position="386"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="412"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="438"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="449"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS20550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="475" mass="54040" checksum="F95E68CB387A0FE7" modified="2011-10-19" version="1">MAGLPPETIHVKRKRGTDDNPVDFLRLERSKRYRLSGESGWVYQRKVPENEITRHVVEPATSVVPTIQPTKKGDEHRLRGVTNKGRDVPAAARGSTPSSTPKSTGSSETVTTAQSEGQTTDQSPSDRIRRFHLSKASSLQLTSGVSKKRSAPAVFVERDAKKQRESLKSLVEERNITVTEHSLKGLEWTAAPASQAPPAKLKRPGLRARTKPTTSASVAESSKTGTQTETSKSESQTKTSKLPPSLRNRESDADMNQLARIMDSWTLEEITKNLDRMEEDKTTSKFSAPSPYKSRFRPKAPKLRWFERHPEAAAQQQQKGVKGAENMNIDVAVADGDVADSDDDYIIETYERVPIERLHEKNVPEDKVGLLVFDSEPDMVEFFYGNEEDSDDQFPEDEEDENAENYYTHEYPDEDLDWDDELDRDPYQYTNQNASDREEYDERDFIDEVWDRCDREDDDDNKGGTEELPPWRPRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0S546</accession>
    <name>G0S546_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isochorismatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0024050</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
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        <property type="protein sequence ID" value="EGS20571.1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="OMA" id="HVCVFQT"/>
    <dbReference type="OrthoDB" id="269496at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR050993">
        <property type="entry name" value="Isochorismatase_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119:SF3">
        <property type="entry name" value="ISOCHORISMATASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="2">
        <location>
            <begin position="14"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS20571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="211" mass="23135" checksum="7B7CBB6064A980C1" modified="2011-10-19" version="1">MAAPVPERRFKNPALFVCDIQEKFRPTIFELDKVILTTRKMLLSSLHLSIPIFVTTQNRTRLGDTVSELKPLLQQAADKGLLQADLDKTRFSMYLPAIASHPIFSSGKKAEVAIVGIESHICVTQSALDLLAAGHRVYIIADGVSSSNKEEVGIALQRLRQAGAIVTSSESWLYELMGDAAIPEFKGMVNVVKETMRDTRAALQGLLGSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5X3</accession>
    <name>G0S5X3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Polymer-forming cytoskeletal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0025250</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006692922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5X3"/>
    <dbReference type="GeneID" id="18256563"/>
    <dbReference type="KEGG" id="cthr:CTHT_0025250"/>
    <dbReference type="eggNOG" id="ENOG502T0K4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087646_0_0_1"/>
    <dbReference type="OrthoDB" id="5194604at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007607">
        <property type="entry name" value="BacA/B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04519">
        <property type="entry name" value="Bactofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="29308" checksum="EA9CA47E0A12BB58" modified="2011-10-19" version="1">MKRGSTPPMSMTTESSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSLSSPSTTAEHSKRPRTSVSTTHSTTPTVTTTASSSSSSSSSPQTTSSEAVTMYEYEQIITFDQPIMLAGSSSSFYPSHNANKMRSIKSDDPLDLRGPMEVDGSVKSMSSVTFRGDFSVKDRIEAYGDVDIQGNLSCGGKFKSMGNVKIRGSVVCTDKVKVFGKLRIHGTLEVQGDLEVYGSLTIDGYLKCKILTAYDSLTTVGDQSWYEVEQGETVQGAKLIQRHNYAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5Z2</accession>
    <name>G0S5Z2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MIOS-like alpha-solenoid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0025440</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693004.1">
        <property type="nucleotide sequence ID" value="XM_006692941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5Z2"/>
    <dbReference type="STRING" id="759272.G0S5Z2"/>
    <dbReference type="GeneID" id="18256582"/>
    <dbReference type="KEGG" id="cthr:CTHT_0025440"/>
    <dbReference type="eggNOG" id="KOG1008">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005843_0_0_1"/>
    <dbReference type="OMA" id="YEPTGHA"/>
    <dbReference type="OrthoDB" id="341486at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001167">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037593">
        <property type="entry name" value="MIOS/Sea4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049092">
        <property type="entry name" value="MIOS_a-sol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453:SF9">
        <property type="entry name" value="GATOR COMPLEX PROTEIN MIOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453">
        <property type="entry name" value="WD40 DOMAIN-CONTAINING PROTEIN MIO FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21719">
        <property type="entry name" value="MIOS_a-sol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIOS-like alpha-solenoid" evidence="2">
        <location>
            <begin position="539"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="926"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="926"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="939"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="967"/>
            <end position="981"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS20708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1022" mass="113330" checksum="C1B8713145F18C97" modified="2011-10-19" version="1">MDRQEPGLIKWSPNAAHDSFLHISLQERVVQLYEPTGLAQRGRFEYRKLAKHNDLPPLTAYDWSPTVPGIVAVGTQTGVVNLLRIDDNSNGYQELALKISRTCQAVAFNTGGKLAVALDRVRSDHCLYIWDVSRLSSLNDAHIVGLPPDLGLPLDPVDRLEHNASVSSIRFFEDNPNVLVAGIKGQGLRIHDLRDHAHSSVAYFQTKCCNNLAIDYADQNYFASSALDQPGVMIWDRRALNRHTVSSSYAEALDRDGLCWGGALRLDRAVHVDPNDPAALDAKSSMIRSLRFCRDHPGMLAVLSQTGQLRVFSARHEHLDPDARVASSPELLEVRRSYEMDPLYAEPGRKSERIVSFDWITMSSPVLKPRVLVLRANGTFDVLEKPSFTSEYPFKLVPWQPPYRGLDGTDYQELMEFEPSQEERIFAPFLTEQALTDVPLFGPNKASVRTLVEKTLADGLSQHTLAVSGGSDQRTSVSKEAPTVADKLKALRKAAKNSEGNSEGLLSQLERRESLLSCTRDMTGLSSQDRYVLDHVMLLRAQEGYRFDPIKNQGIVADDPWLKDAWAWVAGAEAAAFDDGMVAFPLDVGYMGVHTIWNNDLGSRPEMRLAEDAELPDEAGWERCLNTINKQLRIPKFDGQVKTRRPHHRAMCLAICGFGRSDTEDMEFSSPSKRESTWYTMVAAQALFRGDTKGAVQVLKKASTEYPELLFVSLALQLMGKNGGHDGETNVALDFDEKVASRTDPYLRAISAIIATGDWAVIANQRSLPLRDRCFVAVRNLDDDALTAWLDREVSLAIETGDIEGIVLTGITDRLVDILARYVHKFNDFQTATLLLSICAPRFIDDIRATAFRNAYRNYLQRHRAFFLRAKFDVESTKRSKHRGVPTLRPAARQIGLRCVYCDVAIKQEQLANTSVSTLPFRASTGSSGITATNPATQNSPNPSGSLSNPATPRLLPGGSAAASRAGTPSSRSEFRYHQQQQAAGSAYTDKLVSAGISCPNCKQHLPRYLDMINVDEATCSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0S604</accession>
    <name>G0S604_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Single-stranded DNA-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0025560</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693016.1">
        <property type="nucleotide sequence ID" value="XM_006692953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S604"/>
    <dbReference type="STRING" id="759272.G0S604"/>
    <dbReference type="GeneID" id="18256594"/>
    <dbReference type="KEGG" id="cthr:CTHT_0025560"/>
    <dbReference type="eggNOG" id="ENOG502S0M8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126647_0_0_1"/>
    <dbReference type="OMA" id="TQYVRKG"/>
    <dbReference type="OrthoDB" id="1078367at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="SINGLE-STRANDED DNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302:SF0">
        <property type="entry name" value="SINGLE-STRANDED DNA-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002070">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR002070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS20720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="149" mass="16822" checksum="0737BDBFFA984F1F" modified="2011-10-19" version="1">MSAFLRSASRTAVSSARSFSTSSPREVARITVIGRLADTPELRTSASGRQWLRYTVNTRSGPASNPKTSWWNVNAWIEEGPQRQFLQNLPKGSLVMVDGDVTIDQWVTAEGTQRSALNIRHRSIEVLRRPRRNIQEGEQQESQQEGQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6E9</accession>
    <name>G0S6E9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0034670</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693900.1">
        <property type="nucleotide sequence ID" value="XM_006693837.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S6E9"/>
    <dbReference type="GeneID" id="18257505"/>
    <dbReference type="KEGG" id="cthr:CTHT_0034670"/>
    <dbReference type="eggNOG" id="KOG1240">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001696_0_1_1"/>
    <dbReference type="OMA" id="ATNTCRI"/>
    <dbReference type="OrthoDB" id="242910at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071561">
        <property type="term" value="C:nucleus-vacuole junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13980">
        <property type="entry name" value="STKc_Vps15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000497">
        <property type="entry name" value="Phosphoinositide 3-kinase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000542">
        <property type="entry name" value="Phosphoinositide 3-kinase regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001688">
        <property type="entry name" value="Phosphoinositide 3-kinase regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045162">
        <property type="entry name" value="Vps15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583:SF0">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="25"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="1119"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="925"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1092"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1457"/>
            <end position="1537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="954"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1092"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1468"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1491"/>
            <end position="1537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS21604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1582" mass="175950" checksum="EE7564ADE3A83634" modified="2011-10-19" version="1">MGQGFSLAAPPAGAAGIDVPELADLVYEKSIGNGRFMKSVRARHRDGVVLAKVLIKPYPMSLEPYKKAILRERRALANVPNALPYHRAIETETNGYLVRQFLYNSLYDRLSTRPFLEDIEKKWLAFQLLCALRDCHAKDVYHGDIKTENVLVTSWNWLYLSDFSSSFKRVMLPEDNPADFSYFFDTSGKRTCYLAPERFLPPGQDADPNAKVTWAMDIFSAGCVIAELFLETPIFNLAQLFMYRKGEYDPSISHLSRIPDKDLREMIAHMIQLDPEKRYSAEQYLEFWKGKVFPEYFYNFLHQYMELITHISSNQSLLPSSARHLSQPDQRIERVWLDFDKISYFLGYQTGLHHDEEPQLSSWLGLGHFPVRLNIPNNEHYVSAEKQPSADDGTLIFLNLIVSSLRNTQHASAKIKACDILLAFAERLSDEAKLDRVLPYLMALLTDKCDMVVVAAIRTITQLLDLVKIINPVNSQVFLDYIMPRLQPALLNPQRPSSPIVRATYASCLGKLATTATRFLALAAALRADGSGAFSDPEVEPGNEPKATFDGLYDDTRRELAEIFETHTKALIEDSDPFVRRAFLTSVPDLCIFFGAAQANDIILTHLNTYLNDRDWTLKCAFFDTIVGISAFLGSNTLEKFILPLMAQAVTDPEEHVVHSALHSLAELASLGLLTKQTYLELVGGIARFTMHPNPWIRVSAVDFIAAGRHSLSQAYLRVMVQPHLIPYLKPERLVDFSKLGLLDTLQKPLSRTVFDQSLVWASKSEKSDFWKPFRRSREAGPTPMNSSGVMSISGSQVLSAKSAKNEEDEQWLNKLRNLGLSKDDEPKLFALREFIWRLSQIKARDSATQETVNTSQLNSIIPLRSLGITPQTVLFDETRPTKTLPDQDAGAPKTIKDALLDASMSVDGPINKKKRFAVNTYRSNLSSTDKMSPQAADGKIIQEEDGSTSTAKPGERSRDDATHRPSTAHGKAAVGPTDDAASVSSKKTLRFQPCAISLMNRNDNTKASPETGTTEANAFGEVEAPLSQTPVRLPSFPDTESVLGKNKERLRPNHSYSGNDPNILKMLNAMYIDNYPHDIIEYGPLVTPISQKRASNRTTASRPKDDGWKPSGKLVATFSEHTGAINRVVVSPDHQFFLTGGDDGCVKVWDTARLERNITHRSRLTHKHAPGAKVVALCFIESTHSFISCATDGSVHVVKVDTVFSGNTFRYPRLRLLREYQLADGEYAVWCEHFKQEASSVLILATNKSVILGIDLRTMSLLYRLENPVHHGTPTCFCVDRKRNWLCLATSHGVLDLWDLRFKMRLKAWGVPGKGAIYRLAIHPTKGRGKWVCVAGGTGQGEVTVWDLERTLCREVYRVSGNKEGPKGYEAWEVDEDKPEGMLGRFATDIDPASSAITMGGNADRGVRAMYVGIADSISSPGEDRDIRHAFIITAGSDKKLRFWDLGRIENSVVYSGLQPDEGRPTFTASHPTPSMTLNTERWPRQQDHSASSSAVAAGAGANGGSLSPSSRRGSTNTSTTGGSRSSGTVGGRPPRSTVISLQQQQLLKSHLDAVTDVAVLESPYMMSVSVDRSGVVFVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6H6</accession>
    <name>G0S6H6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0034950</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693927.1">
        <property type="nucleotide sequence ID" value="XM_006693864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6H6"/>
    <dbReference type="STRING" id="759272.G0S6H6"/>
    <dbReference type="GeneID" id="18257533"/>
    <dbReference type="KEGG" id="cthr:CTHT_0034950"/>
    <dbReference type="eggNOG" id="KOG3957">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4323">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_294399_0_0_1"/>
    <dbReference type="OMA" id="KDEQAPW"/>
    <dbReference type="OrthoDB" id="5863171at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047369">
        <property type="term" value="F:succinate-hydroxymethylglutarate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15502">
        <property type="entry name" value="PHD_Phf1p_Phf2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1540.10:FF:000005">
        <property type="entry name" value="succinate--hydroxymethylglutarate CoA-transferase isoform X4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050483">
        <property type="entry name" value="CoA-transferase_III_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207:SF3">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="764"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="436"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="565"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="657"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="825"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="894"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="939"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="456"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="488"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="565"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="584"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="721"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="825"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="894"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="958"/>
            <end position="968"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS21631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1030" mass="111013" checksum="14A6B2016A114BCC" modified="2011-10-19" version="1">MFRLLTVSRRLLRTGTLNPAGPRRFTVSAVMAADGTLPLEGYRVLDMTRVLAGPYCTQILGDLGAEVIKIEHPIRGDDTRAWGPPYAPYKSSSAHQGPGESAYFLGVNRNKKSLALSFQDPAGVEILHKLAAKCDILVENYIPGSLKKYGLDYETIHKINPSLVYASITGYGQTGPYSQRAGYDVMVEAEFGLMHITGTRDGPPVKVGVAVTDLTTGLYTCTSIMAALIARAKTGKGQHIDAALSDCQTVTLANIASSCLISGEKDTGRWGTAHPSIVPYRAFKTKDGDVLFGGGNDRLFGILCDGLGCPEWKDDPRYKTNALRVANRDELETEIEKITVTKTTQEWLEVFEGKGMPYAAVNDIQGTLNHEHTKARNMVTEVEHPECGPIKLLNSPIKFSETKPKIRSPPPTLGQHTDEILREHLGMSEHEIKSLRDRGIIRSKGQTMADSGTSKDSSKSDGGHSVKDTASTSAGARASEAETEPKPAVTPTPPSSIPPTRPPYIPQFTAATQMILSRLKGEPSSLSTALSQAARSPSVTSAISTSSYEDVKRRLVMSMNTSTSLTMKMPSSSSTQSMPATLPMPSAMTVSTTPTTTTTTTTMMTTTTTAAAAAAVNSTSATTTIGPARSSISTAGMSAIRKVQAGLTSITKSPVAKVAQNKTAPMESKIKKLKTSAIVPRGVGSKRKRARNKDDDDDDDDASSASSFSEQSGSEAPIDGASQSMPLTTTKSGRSVMKPDSYNPAAMEAASKKRANYGKRTTEQALCKNCTRMYSPAGNRMVFCDGCNDGWHQLCHDPWIQDDVVGDQARGWFCSACTTKRHQQQQQQQQQQPQQQPQPKRQKTDPRPARESWASRPPQQKRAYLSTLSQQELVSLLMLALEMHPDLPIFPASPSGAGAASSHGTAGQAPRSLFAGTSTDGLFSRAEAHPTGQINYVRKISNANGNGNGKGRGSANGTKKEKEETPRLEEEEGFDPLAALWPKPGMGLYRQLPPDTEDNDRLVDQGDFEAFSSIIFDDRGRKVEENGMPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6K3</accession>
    <name>G0S6K3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative specific RNA polymerase II transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0026520</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693110.1">
        <property type="nucleotide sequence ID" value="XM_006693047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6K3"/>
    <dbReference type="STRING" id="759272.G0S6K3"/>
    <dbReference type="GeneID" id="18256690"/>
    <dbReference type="KEGG" id="cthr:CTHT_0026520"/>
    <dbReference type="eggNOG" id="ENOG502QQTI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007201_1_0_1"/>
    <dbReference type="OMA" id="DWHPRNL"/>
    <dbReference type="OrthoDB" id="2262349at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000012">
        <property type="entry name" value="C6 transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052780">
        <property type="entry name" value="AAA_Catabolism_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="128"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="205"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="279"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="520"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="637"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="920"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="994"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="52"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="651"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="930"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1000"/>
            <end position="1010"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS20814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1103" mass="120580" checksum="9BA77D18B918BED5" modified="2011-10-19" version="1">MAHFAAPSLPLQSLSPVSPVPPSSTTSSGGNPAGAAAAAPSTSTRGGPGSGPSPSATTPSQPVQPVQPSSSGSAPTPAQAPQQPHDQQQQQQQQPPQPPPPPPPQQPQPEPPRYRPPNPPQHKRVYQACIPCRRRKVRCDLGSVDDPHDPPCVRCRRESKECFFSATRRKRKADEDDPELEEYILRNGRKQARGASVTLDRRYYSDMPLTPHGRAQSSRRMGDSAKSVRSNSSAGGEFGNGEPNTPLENLEARTVMRREVYGPHDALDLLYKAATDKFNDTSSQKPEDDPAPNHAATHSTSRHLRQESEPRKLSSTTASGGYHSRHASRHETSADNAIDPELTRRDPTSDPGYQEALKAWNRFRFVRAGWFTAQEAIDYIDYYYKYLSPLTPISPPTFQNPASHLTLLTEEPILAVTLLTIASRYRRMPGTGGHCRSHAIHEQLWTYLRGMIERVVWGQEAFGGGFCGSGADENQSSSTAPWRGLRRGSLRTLGTIESLMILTEWHPRALHFPPNEATDELLVPAPDAKPPSDSDGTQKPGGSFGGRRIESWLEPAWRSDRMCWMLLSTAMGLAYELGVFDDIDELLATGAITRPEYEDEAYRLRANRIKRLLLIYLSQLAGRLGWTNMVPEKLRKSDPAISGRKRRASVEGTTPGTNPSSLSNSFNYIPDLELDDQIIHCWAGISHAMQVGNDKLFKSRKHTTEIIQSGKYIELLREFQPMLKNWWNEFERFRLPPYIRHILTIEYEYVRIYINSLSLQAVVERCTSNASGGGGAGGSVSGQSGSTLSPQTQNYYGKLPLGQLGGFGAEDQEYVREVISGSRNLLRTVVDGLLPGEYLKHAPVRTYFRIISGAMFLLKTFALGAPKADVEISIGLMDRTVDALRNCVVDDVHLGIRFADMLETLTSRLRNRFIYAVPPQMPPADGRSPAATNGDGANGNSAASGMTTHLSHVQDMFMKMRDSSGPPERSATPANISATPWDFSAGAFPYPGGPGSVFGPSTPAAATSTTMDNTNNPHGLPADGSSSVTTGSGAGGVIFDSDWANPNNEMWYLPTGPAFFQNIDNTSVSMTAEGVNVGGLDLLEYMAMDPIDNQPFGMDGGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6T5</accession>
    <name>G0S6T5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">rRNA biogenesis protein RRP5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Ribosomal RNA-processing protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0026810</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2019" name="Mol. Cell" volume="75" first="1256" last="1269.e7">
            <title>Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration.</title>
            <authorList>
                <person name="Cheng J."/>
                <person name="Bassler J."/>
                <person name="Fischer P."/>
                <person name="Lau B."/>
                <person name="Kellner N."/>
                <person name="Kunze R."/>
                <person name="Griesel S."/>
                <person name="Kallas M."/>
                <person name="Berninghausen O."/>
                <person name="Strauss D."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="31378463"/>
            <dbReference type="DOI" id="10.1016/j.molcel.2019.06.032"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (4.40 ANGSTROMS)</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the biogenesis of rRNA. Required for the formation of 18S and 5.8S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693139.1">
        <property type="nucleotide sequence ID" value="XM_006693076.1"/>
    </dbReference>
    <dbReference type="PDB" id="6RXY">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.70 A"/>
        <property type="chains" value="Cz=1-1796"/>
    </dbReference>
    <dbReference type="PDB" id="6RXZ">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.40 A"/>
        <property type="chains" value="Cz=1-1796"/>
    </dbReference>
    <dbReference type="PDBsum" id="6RXY"/>
    <dbReference type="PDBsum" id="6RXZ"/>
    <dbReference type="EMDB" id="EMD-10055"/>
    <dbReference type="EMDB" id="EMD-10056"/>
    <dbReference type="SMR" id="G0S6T5"/>
    <dbReference type="STRING" id="759272.G0S6T5"/>
    <dbReference type="GeneID" id="18256719"/>
    <dbReference type="KEGG" id="cthr:CTHT_0026810"/>
    <dbReference type="eggNOG" id="KOG1070">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000845_0_0_1"/>
    <dbReference type="OMA" id="GQYLRAY"/>
    <dbReference type="OrthoDB" id="412781at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05702">
        <property type="entry name" value="S1_Rrp5_repeat_hs11_sc8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05703">
        <property type="entry name" value="S1_Rrp5_repeat_hs12_sc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05693">
        <property type="entry name" value="S1_Rrp5_repeat_hs1_sc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05697">
        <property type="entry name" value="S1_Rrp5_repeat_hs5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05698">
        <property type="entry name" value="S1_Rrp5_repeat_hs6_sc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05706">
        <property type="entry name" value="S1_Rrp5_repeat_sc10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05707">
        <property type="entry name" value="S1_Rrp5_repeat_sc11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05708">
        <property type="entry name" value="S1_Rrp5_repeat_sc12"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="protein RRP5 homolog"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000155">
        <property type="entry name" value="rRNA biogenesis protein RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="rRNA biogenesis protein rrp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000196">
        <property type="entry name" value="rRNA biogenesis protein RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="rRNA biogenesis protein rrp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000278">
        <property type="entry name" value="rRNA biogenesis protein rrp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000279">
        <property type="entry name" value="rRNA biogenesis protein rrp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045209">
        <property type="entry name" value="Rrp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057301">
        <property type="entry name" value="Rrp5_OB_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057302">
        <property type="entry name" value="Rrp5_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048058">
        <property type="entry name" value="Rrp5_S1_rpt_hs11_sc8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048059">
        <property type="entry name" value="Rrp5_S1_rpt_hs1_sc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 11 PRE-RRNA PROCESSING PROTEIN RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270:SF10">
        <property type="entry name" value="PROTEIN RRP5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24685">
        <property type="entry name" value="OB_RRP5_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23459">
        <property type="entry name" value="S1_RRP5"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="15 16" id="KW-0002">3D-structure</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="10" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="140"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="257"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="448"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="540"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="634"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="722"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="818"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="921"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="1029"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="1116"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="1210"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="1297"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="1581"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1374"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1459"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1750"/>
            <end position="1796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1375"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1750"/>
            <end position="1767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1780"/>
            <end position="1796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00055575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00076674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS20843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="6RXY"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="6RXZ"/>
        </source>
    </evidence>
    <sequence length="1796" mass="197170" checksum="74787B31FA290AA2" modified="2011-10-19" version="1">MGSLKRKEGPDGSSASKSKRAKSGETTKDTKIDSNKDAKQLKTPAVAKPITTPVVTVLKDEEPLFPRGGGSVLTPLEQKQISIQAKKDVLFEEAKKGGKEDTAARSKKKRKSKIEEPATKSKDEDSVKIESLNFKRLVKGSLVLGTICGISPLEIAVALPNNLIGHVPITAISESLTQRLQALQANGEKGDGEESGDENNLDDIDINLFVHLGQYVRAYVVSTIDESVAGKTRRHIELSLYPAHANSGLSEQDIVLNSTLMASVVSVEDHGFVMDIGISDSQLKGFLPRKQLDPSIPEETVQPGSVLLCIVTGKAASGKVVQLSTLVDRLGNPKHFPAEATTIDTFLPGTAAEVLVSEVHTHGLVGKVMGHLDVTADIVHSGSGPDGADLVNQYKVGSRVKARVICNFPTANKPKLGISLLPHVLSLKPKTTTKDGQEVLPTDVLAHSAIIQECRVERVEPGIGLYVNVGVEGVSGFVHISRVKDGKIDTLFENSGPYKIGSVHPGRVVGYNSFDGVYLLSLEKSVLEQPFLRIEDIPIGAVVSGQVEKLVVNTQGFGGLIVKIAEGISGLVPEMHVSDVHLQHPEKKFREGMKVKARVLSTNPARHQVRLTLKKTLVNSDAPAIKSYDELAVGMQAFGTIVAVLQHGAIVQFYGQLRGFLPVSEMSEAYIHDPKEHFRVGQTVSIYVLSFDPEVARLIVSCKDPSAFGLEKQLALKKLQVGDVVSAKVTQKTEDDVFVELIDSSLKAILPVGHLTDKSVNKTQAALKRIHVNQTLTELVVLEKNEGRRSIILSHKPSLVQAGKEGKLISTVDDARLGEQVPGFVRNITASAAFVQFGSKLTALLPKSLMPQDWHDKPNFGLHKYQSLLVKITSIDKELGRLVVAIPSAADQESKKPEKPADQAVNPLDETVTTMADLTIGKLTKARVRAVKETQLNVEIADNIQGRIDVSQIFDKWEDIPDPRRPLKRFKPKDIIDVRVLGIHDARNHRFLPITHRSSHAVLELSAKPSDVQAPSLPEPLSLEKIEVGSTHLAFVNNVASNYLWVNLSPNVRGRISAMEASNDLSKLANLERSFPIGCALKVRVLSVDKEKSRVDLSARTPGASHELTWDMIEQGMVLPAKVTKINDRQVIVKLSESVAGPVHLPDLADDYDEANPLSHSKFEIVRVAVVEVDKSNKKLRLSMRPSRVLNSSLPIKDREITKNTKLQVGDIIRGFVKNVSDKGLFVNLGGDVVALVKIKNLSDSYLKDWKEHFQVDQLVKGRIISLADGRIEMSLKQSVVEKDYVPPITISDLKEGQTVTGKVRKVEEFGAFIDIDGSDRLSGLCHRSEMADRMVQDARTLYNEGDRVKARVLKVDVENKRINLGLKPSYFKDGDEDDVDVDSDSDAGAALNGGADSDSDEEMSDIGGALVVGESDDESDEEKDSDIEMTEAPEEGLIGLEAGGFDWAAANLDADDHGNADVAEVPSKKAKKRREPQGIVDKTAELDVNGPQTASDFERLLLGQPDSSELWIAYMASQMQVNDLSSARQIAERALKTINIREETEKLNVWIAYLNLEVAYGTDETVQEVFKRACTYNDDREVHERLASIYIQSGKYKEAEDLFEKIVKKYGSEAPHVWYNYAHFLHTKSNKPEQARALLKRATQVLGNTKDTYLYLLPKFAALEFRSPNGDREQGRTLFEKLLATYPKRFDLWNQLLDLETSASSVAKNPADPSVIRDLFERGTKVKGLRPRQAKAWFRRWAQWEEKFGDAKSREKVSAKAQEWARAKAAATGKALEDQGQEEGESSGAEEEGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6Z6</accession>
    <name>G0S6Z6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0035600</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693990.1">
        <property type="nucleotide sequence ID" value="XM_006693927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6Z6"/>
    <dbReference type="STRING" id="759272.G0S6Z6"/>
    <dbReference type="GeneID" id="18257598"/>
    <dbReference type="KEGG" id="cthr:CTHT_0035600"/>
    <dbReference type="eggNOG" id="ENOG502QU8E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017709_1_1_1"/>
    <dbReference type="OMA" id="FWFFRMR"/>
    <dbReference type="OrthoDB" id="5368598at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023041">
        <property type="entry name" value="Glucose_rcpt_Git3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022596">
        <property type="entry name" value="GPR1/2/3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF37">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR GPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11710">
        <property type="entry name" value="Git3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11970">
        <property type="entry name" value="GPR_Gpa2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose receptor Git3-like N-terminal" evidence="7">
        <location>
            <begin position="35"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="G protein-coupled receptor GPR1/2/3 C-terminal" evidence="8">
        <location>
            <begin position="405"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="307"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="532"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="246"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="324"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="341"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="557"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="574"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS21694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="583" mass="65706" checksum="C2A448F005F02FC9" modified="2011-10-19" version="1">MPAILLPETVFESLPHTISRRTLSNEQRQHLADVLTTLSLTFASVSVLSTLVALYWFVKMKRNFRHESSDFIKSMAAVIFSVVSLTRGPVRSESAFCQVTGFAFTLGIESSDIAVLLIAIHSAMYIFRPKSGLYPYRQVAYLAYYLSPVITSSLAFIRGNGYENLGHYCYLRSDSGHWNRLMLSWVPRYIICICIVGIYAFIYIYILWHMGDWRREQSELQQTGRRSASSTVPSSPHLCCPDWLISPSSSRRTSATDTIAASKGSRQRTGSVVSNIAQQNFPGSQVSKTQTSQPWTAVHWRWSGFGQTHSGFDSRPSLDHTTEPIPPDAPPISAPPPAHTSDPTSPDPENTHINTSSSDQAHSKPTISRALHRQSQTSHETEQAGTDSSLIQLQSVVDDPAMLRHRERIRKQLRSLFVYPLVYVIVWLFPFISHVVNAETSVYRGDRPAWLLVVSIVSICSQGTADCALFMAREKPWRHSAGRGFWESMGRRIAWSWGGRWFGKGGVGSGDRAGRIREEMLVDGRLARERRQEEIQSERNNVGRSRSKEQGNASMEWWDRWDEEREPEGRRPSGAEPRQSAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G0S704</accession>
    <name>G0S704_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0035680</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693998.1">
        <property type="nucleotide sequence ID" value="XM_006693935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S704"/>
    <dbReference type="GeneID" id="18257606"/>
    <dbReference type="KEGG" id="cthr:CTHT_0035680"/>
    <dbReference type="eggNOG" id="ENOG502QS40">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029138_0_0_1"/>
    <dbReference type="OMA" id="VRYINYS"/>
    <dbReference type="OrthoDB" id="2548233at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42034">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42034:SF1">
        <property type="entry name" value="CONDENSATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS21702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="511" mass="56938" checksum="AFD6A99198A83A04" modified="2011-10-19" version="1">MVVHEKLKWHQTSPGLWQRGIDEVEEFYATMAALYEGSGRMFFAITGHVSIEVDVPSHMSVDESEKRLDAALSKAWICMRYDHPTIASRVSLHSKTHEWIKSYRKILAASDLEDWLRRTFIVLSNGQSGAEFANSDPPAPKDPTCFVLRQPSARGEAGNFIIRRDIVLRSPHDIIDGIGTLMLFSNFIARSSEAYSKGDSYPIPLLDGSENANLSPSYRIAAFVPSVLTEAQERRIERIIAQRAAVKSDATVEILTVPFQHGALVPGRHQRSALTLSRDQTSSFLAACKVNGVTPTHVFHAAAAVALRDLQPRPEVTKRVRYISYILRNERSRCAEPFNSTRHPVALYHSVSGNSLVVDLDLRKAGDEPSDQDRKQEFYSVLKTIKAFYEGVRNDSDHYALVPKLWALSTPPLPVPSSHSFPVPLPNAHPSVSISSMGRSDTILTPKMGAFRVSNPWVTGEELGTGWGLFLSTFDGELCLSAAYNDAWHTRETVDDYLKRCRDIAFTCLGL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-06-24" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7R3</accession>
    <accession>G0ZGV6</accession>
    <name>POM34_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleoporin POM34</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Nuclear pore protein POM34</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Pore membrane protein of 34 kDa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">POM34</name>
        <name type="ORF">CTHT_0028530</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 6">Component of the nuclear pore complex (NPC). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="1">Central core structure of the nuclear pore complex.</text>
    </comment>
    <comment type="sequence caution" evidence="5">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="EGS21013" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21013.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JF276301">
        <property type="protein sequence ID" value="AEL00694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693309.1">
        <property type="nucleotide sequence ID" value="XM_006693246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7R3"/>
    <dbReference type="SMR" id="G0S7R3"/>
    <dbReference type="STRING" id="759272.G0S7R3"/>
    <dbReference type="TCDB" id="1.I.1.1.2">
        <property type="family name" value="the nuclear pore complex (npc) family"/>
    </dbReference>
    <dbReference type="GeneID" id="18256891"/>
    <dbReference type="KEGG" id="cthr:CTHT_0028530"/>
    <dbReference type="eggNOG" id="ENOG502S8U7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044363_0_0_1"/>
    <dbReference type="OrthoDB" id="429932at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070762">
        <property type="term" value="C:nuclear pore transmembrane ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030474">
        <property type="term" value="P:spindle pole body duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012578">
        <property type="entry name" value="Nucl_pore_cmplx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28003">
        <property type="entry name" value="NUCLEOPORIN POM34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28003:SF1">
        <property type="entry name" value="NUCLEOPORIN POM34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08058">
        <property type="entry name" value="NPCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0509">mRNA transport</keyword>
    <keyword id="KW-0906">Nuclear pore complex</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000433189" description="Nucleoporin POM34">
        <location>
            <begin position="1"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="134"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="232"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q12445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="21784248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <evidence type="ECO:0000305" key="6">
        <source>
            <dbReference type="PubMed" id="21784248"/>
        </source>
    </evidence>
    <sequence length="326" mass="34279" checksum="E2C521B788DBC07A" modified="2015-06-24" version="2">MSSTLSVAKAASTPVKQITSAVGPVKESPGNWKHPRLAEITRRQSRNIFGEKNVRQIVYNVAAIVLLEIFRVFASPSIPSQLILPSLRPYSLWIHAVFLVIPLTNIVIALLPLFRPVDDLSDIPLTPAQRKLLGLPPSSKPATPNSVYSTPPRYSRTPSLAGSPASIKSYTSSTLPTASSPTPGAAGIGAGSPAAPIYLSPSKFTTSTSSQQFSPSPSGASPLLHRAISNTSTASGVSPYGSPNSPSKFGASTNSTLAASTISTSTFSVSTTSSIAHVLNNSRLRESVIEGVPATPTPVGKGASVKANSKWLYQRGRRTSSNNWVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7V8</accession>
    <name>G0S7V8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0037160</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694141.1">
        <property type="nucleotide sequence ID" value="XM_006694078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7V8"/>
    <dbReference type="GeneID" id="18257754"/>
    <dbReference type="KEGG" id="cthr:CTHT_0037160"/>
    <dbReference type="eggNOG" id="ENOG502S025">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1255849_0_0_1"/>
    <dbReference type="OrthoDB" id="3648173at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="35"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="186"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="191"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS21845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="220" mass="24166" checksum="334033029A8519B8" modified="2011-10-19" version="1">MLEHGSHIMKAWWFALLFYILTLFLTKVSICVFLVIATDFMIFLLPVPVVYPLKLPRRQKFALVTIFAIGFFVCLISLIRLWILIKTQSNPNPDFTYAGTPLIYWTVIEVDTAIVVACAMTLKPLITRFFPNLLIPRSIWDASVLESNGRPRTIGSAPWRPGGGARGIGDVGMESMRNGDSVDLGLGGGQVSPSEGTDVGSTWGRSNGEELGKMTAKSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0S893</accession>
    <name>G0S893_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0038010</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694223.1">
        <property type="nucleotide sequence ID" value="XM_006694160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S893"/>
    <dbReference type="STRING" id="759272.G0S893"/>
    <dbReference type="GeneID" id="18257839"/>
    <dbReference type="KEGG" id="cthr:CTHT_0038010"/>
    <dbReference type="eggNOG" id="KOG1716">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049471_1_0_1"/>
    <dbReference type="OMA" id="PFVEREP"/>
    <dbReference type="OrthoDB" id="10252009at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140096">
        <property type="term" value="F:catalytic activity, acting on a protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990444">
        <property type="term" value="F:F-box domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062026">
        <property type="term" value="P:negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070372">
        <property type="term" value="P:regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052449">
        <property type="entry name" value="STYX-Interacting_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588">
        <property type="entry name" value="SERINE/THREONINE/TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588:SF1">
        <property type="entry name" value="SERINE_THREONINE_TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="215"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS21927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="387" mass="42603" checksum="D553A3769B9039CB" modified="2011-10-19" version="1">MLSNQHSDRTRAHSPLRPGVLPTAPYSTRPPSPPYIHVPAVPFPAAPFPAATSTTTTGNLSTSSNPSDANTRARTPSPFSNILMTITPSPNAVHYSQYTPTPLSHADLALVTRNLAPQYAKDASTNWVYESRRQAQQVLDWVYLGPASVVRDKVFMEREGITMVLAARDKRFAAVSLPGLKRALEGTGVEVEGVEVGDARELVRVFDVVVGIINRHMLRIERERVENEGQGKPGKVLVCCETGNDRSAAIVAAYLMAMFALDTVQAVQYMLLKRFCVTLGDETKHMLQAYGDILRARGDVGVMMSTSTTAPAMPAVTNVSAQGQQSHQQPLQPPQQYLQPHPTKRRIEETRYVEMDDGIDPDDVMSDAMDEERYAGRSFAPFVEREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8L0</accession>
    <name>G0S8L0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0038460</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694266.1">
        <property type="nucleotide sequence ID" value="XM_006694203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8L0"/>
    <dbReference type="STRING" id="759272.G0S8L0"/>
    <dbReference type="GeneID" id="18257884"/>
    <dbReference type="KEGG" id="cthr:CTHT_0038460"/>
    <dbReference type="eggNOG" id="KOG0191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021868_0_0_1"/>
    <dbReference type="OMA" id="IFVYFYD"/>
    <dbReference type="OrthoDB" id="72053at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052250">
        <property type="entry name" value="PDI_TMX3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426:SF1">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408902" description="Thioredoxin domain-containing protein" evidence="6">
        <location>
            <begin position="20"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="14"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="275"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="162"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS21970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="750" mass="85676" checksum="3F646C0E598E372A" modified="2011-10-19" version="1">MRLSSWLLWGAAALAVASPEDDKKTKDATYFNGKKVPPLLEITQDTWEKERKASRFLLVKHFSPWCPHCQDFAPTFQTLYEFYYTSTPAGDAPKNVDFTSFYDFRFAEINCVAFNDLCSQHKVSSYPTTILYENGEPISTLKGDKAIDILSVMVEDALEKAKPGTRPAKLRLPKPGDKSAPQPVEDTTVTKHDEAKAAAVPNTNEHEPDLKKNELPTTGAPKVEEPKAEPKQEGVKKVDEPQKAIDLAPSTPEAKPDPTSKPYSSPSPTYVWEPPVPPIKKPSGPVNQQGASVPLTAEDFQRLVTLTQDPWFIKFYAPWCHHCKALAPTWEQLAKEMKGRLNIGEVNCDKEPRLCKDVRIKGYPTMLFFRGGERVEYQGLRGLGDLLQYAKRCIEVSNGVQDVDYDTFKALEEKEPVIFLYFYDHATTTEDFIALERLPMTIMSHARLVKTRDPRLYERFKISTWPRLLVSREGRPTYYPPLSPREMRDTRLLLDWMRSVWLPLVPELTAANAREIMDGKYVVMGILNREDESSFNTAIRELKTAANEWMDRQIQLFRMERQELRDAKQLRIEEAEDRGDERRLRDAKNIRINMNLSRRKEVVFCWVDGVFWQRWLRTTYGVDIKENGERVIINDADNRRYWDTTSTGNPIVPSRTSILETLTKITANPPKIKPKLTIGFIEKIFFDIRVSFRDHPYLSSGCVLGIAFGVLSWFRGRIRLPSLRRSGYLRLEEGAAAALGLGGGSGEKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8P2</accession>
    <name>G0S8P2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bola-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0039840</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BolA/IbaG family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988042">
        <property type="protein sequence ID" value="EGS20245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694394.1">
        <property type="nucleotide sequence ID" value="XM_006694331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8P2"/>
    <dbReference type="STRING" id="759272.G0S8P2"/>
    <dbReference type="GeneID" id="18258022"/>
    <dbReference type="KEGG" id="cthr:CTHT_0039840"/>
    <dbReference type="eggNOG" id="KOG3348">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109462_0_0_1"/>
    <dbReference type="OMA" id="AIMICNT"/>
    <dbReference type="OrthoDB" id="203381at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052275">
        <property type="entry name" value="Mt_Fe-S_assembly_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46188">
        <property type="entry name" value="BOLA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46188:SF1">
        <property type="entry name" value="BOLA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS20245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="166" mass="18136" checksum="37255F980FDE1D9E" modified="2011-10-19" version="1">MFCRACLRANAVFIDAVPSSRLLLWTSQRRSVAALVSSSRTSSILRQTQTSTKLPNQRMFSTSRILSSSPAPAEGASSAATSTIPEKPTYLTEGESQVWDRLVAEFAPTELIVRDISGGCGSMYGIDITSEKFKGLTILKQQRLVNAALKDLMKDWHGVQLKTKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8T2</accession>
    <name>G0S8T2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0040240</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988042">
        <property type="protein sequence ID" value="EGS20285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694434.1">
        <property type="nucleotide sequence ID" value="XM_006694371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8T2"/>
    <dbReference type="STRING" id="759272.G0S8T2"/>
    <dbReference type="GeneID" id="18258062"/>
    <dbReference type="KEGG" id="cthr:CTHT_0040240"/>
    <dbReference type="eggNOG" id="ENOG502STK7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099909_0_0_1"/>
    <dbReference type="OMA" id="AMMWANA"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39608">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G08640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39608:SF2">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS20285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="26397" checksum="98176899A6D7B9F5" modified="2011-10-19" version="1">MDAGSDFWTGSIVRGLLGLHNFLIFASSAILVGLLSYLLHHSGYRGRHLIFEEVIAVITLFFYLIAIFLPIFKSYRGYMLPLNFVLTYLWITCLIFSSQDYSGNGCLFHTPPLFGRCGLKHAIQAFWIIGFVYLFFNTILEAMMWANAKLREGRRAGDAEKGATTMAGTTAGGTNSGAAATALPPPLPHAREPDHPLVLSPGAKTPAPKWPAPTRADGYPIGRGIQIGKVGVQRPGGLECGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8X4</accession>
    <name>G0S8X4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative chromosome transmission fidelity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0043770</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694770.1">
        <property type="nucleotide sequence ID" value="XM_006694707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8X4"/>
    <dbReference type="STRING" id="759272.G0S8X4"/>
    <dbReference type="GeneID" id="18258415"/>
    <dbReference type="KEGG" id="cthr:CTHT_0043770"/>
    <dbReference type="eggNOG" id="ENOG502SN0Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002639_5_5_1"/>
    <dbReference type="OMA" id="THITHHE"/>
    <dbReference type="OrthoDB" id="5347061at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF9">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="48"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="508" mass="57518" checksum="0481838985DE0E95" modified="2011-10-19" version="1">MFPLSDRPDRGRLWIKSKLGLTLLDLGVDPSESAPIRLIESAGKNGRYVTLSYCWGKAKFLKTTKDNYTRHKQGILFADLPRTFQHTIRVCRALGVRYLWIDALCIIQDDSQDWAAESVRMADVYQKSFFTLSATWGDSPDCGLFQDFDTASESRIGPVALRQVVHPTLTHITHHENEFPVLTRGWCYQEHLLSRRILYFTMWEVMLQCLESTICECGSSIHKSRGTEQEKYKQFFCCPEDQHPASPSATSPDVASNFWHVTVSDYTLLRLTYSSDKLPAISGIATVIQRKTNWHYLAGLWRETLLTDLCWYVWPPPPAPPNATSSPCGGKPQKQRRKSPTWSWITIPHSNCIHYQAALLSFYQKMPIHLTLHASILDAGCTPPSSMSEVHSGFIVLECYMQQIPLTMMQALVMDLTQGLALDEGLDTPLEEGPFYLIPMVAYVSGDEWFKYTGYTALVVTPAEEGKDEMVRVGLLICHVNPATGGKPGTYKIWERAVNGKKVRIRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8Z4</accession>
    <name>G0S8Z4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0043980</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Required to prevent the proteolysis of the CreB deubiquitinating enzyme in the absence of carbon catabolite repression. CreB deubiquitinating enzyme stabilized in a complex with the CreC leads to the expression of genes such as those in the proline and quinate pathways.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with creB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat creC family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694790.1">
        <property type="nucleotide sequence ID" value="XM_006694727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8Z4"/>
    <dbReference type="STRING" id="759272.G0S8Z4"/>
    <dbReference type="GeneID" id="18258436"/>
    <dbReference type="KEGG" id="cthr:CTHT_0043980"/>
    <dbReference type="eggNOG" id="KOG2394">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016971_1_1_1"/>
    <dbReference type="OMA" id="GVARFWM"/>
    <dbReference type="OrthoDB" id="3367at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045013">
        <property type="term" value="P:carbon catabolite repression of transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051362">
        <property type="entry name" value="WD_repeat_creC_regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107:SF16">
        <property type="entry name" value="AT02583P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="438"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="94"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="168"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="475"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="579"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="475"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="581"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="609"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS19905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="705" mass="75854" checksum="32317DC29E7EE6D0" modified="2011-10-19" version="1">MVETNNQLSHPSGPQYQFLVGEGLYVLKEDLHLATPPPHPSEAPVVNPNPLSTAPQPATSGTKVSLITLDIPNNSNSINASSGPSTVIYRTLSRKDSTIQQQQQQQQQPIASTAGSIREHPDESQSSTDVRESISDAGRLGTSSAGGGNAATASDVTVPLFASSNASSSAATPAFGESNSLLSSQRDSGSSKGKLRKPKNNMSKTNSSFISRVICHEALGKRLQERAKDGLLAFANVGRAFQWLDLSSAIKAEYLTKILLTRAHCLCHDVNKITKSQSHIDMVMGFSTGEIIWWEPISQRYTRLNKNGIINRTPVSEIKWIPGSENLFLAAHWDGSLVVYDKEKEDAAFVSEDDAVSGGRPSVETVRTSRVNYSKQMHVLKSVNSKNQKTNPVAVWKLSNHRINAFAFSPDCRHLAVVSEDGSLRVIDYLREELLHIFYSYYSGFTCVCWSPDGKYIVTGGQDDLLSIWCPSEASSPRPQRGLTSGSTANVSTSDVSPNGTNAAAAETDTLNGSSSAVPGGLVARCQGHHSWVTSVAFDPWRCDDKNYRFGSVGEDCRICLWDFSVGMLNRPRAASVRQRGASNSFAPESGAVTSNGGEGVQGSRVRSDSTMSSMSRPDTANASAPAGAGDDSKAKKREVLVHPVQSRAATAMLPPVLSKVIDDDPLSWIGFTPDAIMTSCKSGHIRTWSRPSELTPEVGGHTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9C1</accession>
    <name>G0S9C1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CTHT_0045300</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694917.1">
        <property type="nucleotide sequence ID" value="XM_006694854.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S9C1"/>
    <dbReference type="GeneID" id="18258568"/>
    <dbReference type="KEGG" id="cthr:CTHT_0045300"/>
    <dbReference type="eggNOG" id="KOG0261">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000487_3_0_1"/>
    <dbReference type="OMA" id="AVCPPYN"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02736">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02583">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035698">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035697">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015700">
        <property type="entry name" value="RPC1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="15">
        <location>
            <begin position="262"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGS20032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1541" mass="173198" checksum="4742574FAF23A4B2" modified="2011-10-19" version="1">MSVAVTRRRKEQVVDQRPKRFKALKFGIQSHQDIVSQGVLEVSDNLLYDVENNRTAFPHGPLDPRMGTSSTNRDAKCATCNMGLQDCPGHFGHVRLPLPVFHIGYLKYIQTTLQNICKDCARVLLTEPERRQFLKELRRPGIDNLRRAAILKKINEQCRKVKQCPYCGEIQGVIRKLSVMKLVHDKYAAYNKSTAQKKIAPESKVEFDASFENAKKYTPELEKHTKKAMDDLNPLKVLNLFKRISPTDCELLGLDPTEGRPEMFLWQYIPAPPICIRPSVAQENASNEDDITSKLSEIILYAGHLRESLKKGVSLPVIMEQWEFLQLQVGMYVNSDVPGLNQPGFGKPIRGFCQRLKGKQGRFRGNLSGKRVDFSGRTVISPDPNLSIEQVAVPQLVAKNLTYPERVNHANIEKLRQRVINGPNNWPGAMGIIKKDGAKFNLKIGTEALRERHANDLQFGDIVERHLEDNDIVLFNRQPSLHKLSIMSHLVKVRPWRTFRLNECVCTPYNADFDGDEMNLHVPQTEEARAEAINLMGVKHNLITPKNGEPIIAATQDFITAAYLLSSKDKFFDRETFTYICTQMLLGETHLDLPPPAIMKPRCLWTGKQIFNVLMRPNKECPVLVNLDAKNKVFSKKKDGHPPDMDIDDAFLVVRNSEVMCGRMDKATVGGGKKNSVFYVILRDYGPDYAAAAMNRLAKLCARMLTLRGFSIGVGDVWPSGPLTAHKAKLVEDAYKRCDELIETYRQGKLEKAPGCSMEETLENMISGILSQVRQQAGNYCVDSLSNNNAPLIMAKSGSKGSDINVAQMIACVGQQIISGKRVPDGFQDRSLPHFHKNARQPPSKGFVRNSFYTGLTPSEFLFHAISGREGLVDTAVKTAETGYMSRRLMKSLEDLSTQYDDTVRTSEGNVVQFQYGADRLDPVDMEGDAKPVDFARTWNHAQSITWDNKEPGLLPREIQRLCKEILDEERRKYVRRHLVTNEELKYDDETIRTSMDHDVLIAIDEHESVRVYLNTIADYVRSHAMKLARARKSVGLDPCIPEDDEKMRKELEKWQPAGKGLDSMEVDGQTKKPDFVFKELHRDLAEDTPEKRQARAQAHVDRVAKVSERTLRQFIQMCLHKYKKARVEPGHAVGAVGAQSIGEPGTQMTLKTFHFAGVAGMSITQGVPRIKEIINASKLISTPVITCKLENKVDIKAARVVKARIEKTYISDVISYIDDEWLPDVAKIVLQVDLQAVADMQLGITIKDIADAIVKNKKLKLKVEPDDLRVGHDRVEVIVRNTWTDATAARKAARQRAAAIEKGTAMPLTMDESVADFQLRVNFLKRMLPQVAISGYPEANRAIIQTDDKTGEHAVLVEGYGLRQCMTTEGVIGTQCVTNSVMECRDVLGIEAARTTIASEIRSVMKDMNIDPRHMELLADVMTYKGEILGITRFGLAKMRDSVLQLASFEKTPDHLFDAAAGMKKDRILGVSECIIMGQSMSIGTGAFQVVRRLGIRDHQLAPRATVFEEAWKREEGLKRKMKLEKRRGVTGGQEVAVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9D1</accession>
    <name>G0S9D1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAR1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0045410</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694927.1">
        <property type="nucleotide sequence ID" value="XM_006694864.1"/>
    </dbReference>
    <dbReference type="GeneID" id="18258579"/>
    <dbReference type="KEGG" id="cthr:CTHT_0045410"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_262909_0_0_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004330">
        <property type="entry name" value="FAR1_DNA_bnd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03101">
        <property type="entry name" value="FAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAR1" evidence="8">
        <location>
            <begin position="924"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="1188"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="1221"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="1254"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="669"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1053"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="674"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="692"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="721"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="754"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1053"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1074"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1088"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1107"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1125"/>
            <end position="1183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS20042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1283" mass="145047" checksum="910396FBF88E4EC5" modified="2011-10-19" version="1">MFWGTILVGTVTAYWVLRYLFCRLMYPKPLPGIPYIESSLDRILGDLPQIKSHSRMTKETTEGMFAVAKRLGSPIAQLIFPVFQSRRIVIVDDPREAEHILCHRHHEFDRSIVTSQFWLPLFPHSTIAQATTPKLKAQKRLWAGTMNTKFLDRVVAPNMWYASMELVDLWRLKAVASDGNAFDVAKDFSNAALDAIWVAVFGQPLGVLKRELHDLVMVLAKKQGIKPEMFDGEKYHTENMTATEKKRMENAAVVQQAVTYMNEIVLMGFRSFWPALTFSLLKLSPTYRRFKKVTYGKVKELMAQACQRYQREVMLFEAANSDVEGEYLDTCAMDLVLRRQILTAKKEGHPMGDPTKDQAMLEELLLLLLAGHESTAAALSWFTNLIALYPKVQRQLRRTLELAFCMDSAPSTPSTDAINKLFKLPSAAQILAAQIPYLDAVMYETLRFAPPTGAVVRQATVDTTILGCPIPKGTHVMLNTRIFYPPKKLETHGEQAEDVGLGFIGGMETAVRRRDVSVDKGPCGITKLSRSCTQGFELLRDSWSHLERFAPERWLVEKDSEVVFDANALPSLVFGGGYRGCFGRKLAMRELKIMITLLILSFEFLPIESGESILAGEERTFRRPKTCQAFIGELRSLVKTRLLALDDDMSNAYVIQQFQLTVDASAQSTEVVQRARRRRVHPRKNKTTEQPPQNPLSLPPAQEPEQTLDEVSPDREPSPSAQLQVEQTQAAQAELTQEQARTAENNAAAATTTERSRLGPKPKDPTKPPRKRTKNPPEYVKRMKLYQEIDKTVTPEQIEQAKRNYERIYRHQQIHKLYHSIDDYGSAEYLRRPGYLRLTAPLLEAKRQMMAQQPGQWQTPDLEPHEVMEPVDLSKVPAPGTLYDPNGLPYSQPITALQLPKVRPTLCLGPYDTFEEGKNAAIQYAVVQGYMLIQQSSVREKDKDGKYLRDSPILRVDLLCDRAGQCYSQAKTDRRRPTHKLGCPAHLVLLRRRRDGNKWFIDPRCEYHNHDLVPDDMESIAAYRRWKRQMEGLPKETKHEAYLRLRARKMKFAGQGQAGTSQGVSTSQSSAQTPIPQTSPQQMMSTPSLASQAAYAQQALQHHQHRNMSAQTLPQTSSQAMLSYQQQQQTAARIPSPQSLPPLHSQHQQQQQPPSQPTQQQQQQRQQQQPPTQSQSQSCRQQNQPPPNPTSPLHMAAFKGQLKILTMLLDRGADVNMLDGTGRTPLHCAIEGKQLRAVQMLVLRGADISRENSDGLSPLHMAVESGEEEVVAVLLDRGADPNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9H8</accession>
    <name>G0S9H8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative dynein light chain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0045940</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694974.1">
        <property type="nucleotide sequence ID" value="XM_006694911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9H8"/>
    <dbReference type="STRING" id="759272.G0S9H8"/>
    <dbReference type="GeneID" id="18258632"/>
    <dbReference type="KEGG" id="cthr:CTHT_0045940"/>
    <dbReference type="eggNOG" id="ENOG502SQGV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109453_0_0_1"/>
    <dbReference type="OMA" id="YKFACNS"/>
    <dbReference type="OrthoDB" id="10059120at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21456">
        <property type="entry name" value="DLC-like_SpDlc1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF4">
        <property type="entry name" value="DYNEIN LIGHT CHAIN TCTEX-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="147" mass="16200" checksum="5FA6E1B6F62E3430" modified="2011-10-19" version="1">MAAQTNSPIPLKRLEQIANDVCNSVFEGVEFYEHPKTSQWNETIINKMLKAVISEATPQGSTVPTYKFAVNSTIVQHIVPTSQINKPVATTSEDGTTTNKKGQAGRRGMHSATGGYWNEKTDGMWSFKWDGEGKGLDVVIMLIWIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9K6</accession>
    <name>G0S9K6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutaminase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0046220</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695002.1">
        <property type="nucleotide sequence ID" value="XM_006694939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9K6"/>
    <dbReference type="STRING" id="759272.G0S9K6"/>
    <dbReference type="GeneID" id="18258660"/>
    <dbReference type="KEGG" id="cthr:CTHT_0046220"/>
    <dbReference type="eggNOG" id="ENOG502QPQS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008020_1_1_1"/>
    <dbReference type="OMA" id="WAGMIRV"/>
    <dbReference type="OrthoDB" id="431715at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052743">
        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032514">
        <property type="entry name" value="GtaA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033433">
        <property type="entry name" value="GtaA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF1">
        <property type="entry name" value="GLUTAMINASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17168">
        <property type="entry name" value="DUF5127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16335">
        <property type="entry name" value="GtaA_6_Hairpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409416" evidence="1">
        <location>
            <begin position="22"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A N-terminal" evidence="3">
        <location>
            <begin position="102"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="2">
        <location>
            <begin position="337"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS20117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="687" mass="76148" checksum="DDA7638A4D29401B" modified="2011-10-19" version="1">MWLKQIAVTSLAVMGCHCTSARPAFEPARPPAVPLAVRSPYLNAWLQGGSGGVLPGSWPRFWTGHVLGWQGFVSVDGVTYNWLGAAPGPEPVNQTSLTYTSTQSIFTFDVAGKVTMTVNFLSPVYPDDVARQSLQFSYISIKVMSADGKSHQVRTYMDVTGEWASGDINEIVNWETNTTNGIIYHKFFRKNQVEFGEAHEVASWGHWYLSTKAGKDIGPDTEVRNQFVKKSVLKNTKDTSYRAVQENWPVFALAHDLGNITKDGIVERVLTLGIIQDRVIQFAGQSGKLEPVPGLWSSYYPNETAAVVSFYHDYAHALDVSARLDEQIRRDSEAAAGREYALITTLAVRQTFGALQYAGTPAKPYIFLKEISSNSDIQTVDVIFPAYPIFLYLNATLGRFLLEPLFENQESGAYPNAYAEHDLGTFPIAKGYPAGDDEPMPLEECGNMIIMALAYAQRTGDNEYLAKHYKLLSQWAEFLVNDSLIPASQLSTDDFAGTLANQTNLAIKGIIGLKAMSQIAQLTNNKDVFGDVADRYLQEWKRFAINAKASPPHTTLSYGNSNSHGLLYNIYADKLLNLQFIDQAIYDMQSDFYLTVANEYAVPLDSRHNWTKSDWEMFAAAVAKPETRAMFISKLARWISDTTTDRAMTDLFDSVTGAYPANGPVFVARPVVGAVFSILALQEAPPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9T2</accession>
    <name>G0S9T2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="13">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0047070</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 13">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 13">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 13">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="13"/>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695078.1">
        <property type="nucleotide sequence ID" value="XM_006695015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9T2"/>
    <dbReference type="STRING" id="759272.G0S9T2"/>
    <dbReference type="GeneID" id="18258745"/>
    <dbReference type="KEGG" id="cthr:CTHT_0047070"/>
    <dbReference type="eggNOG" id="KOG2467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022477_0_0_1"/>
    <dbReference type="OMA" id="CATTHKV"/>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000097">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF57">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 13" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 12 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="14">
        <location>
            <begin position="58"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS20193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="532" mass="58193" checksum="72D1A3A2521811DA" modified="2011-10-19" version="1">MSATIPGLRRMAVCTAALRGVAGVSRRTISRTLRPAVQRRSVGSAANDAQQRMLAAHLQQADPIMYDIIEKEKTRQKNFINLIPSENFTSQAVLDALGSPMQNKYSEGYPGARYYGGNEFIDASERLCQQRALETFGLDPREWGVNVQALSGAPANLYVYSALMETHDRLMGLDLPHGGHLSHGYQTPTKKISFISKYFETLPYRLNEETGLIDYDKLEETALLYRPKIIVAGASAYSRLIDYARMRDICDKVNAYLMADMAHISGLVAAKVLPGPFTHADIVTTTSHKSLRGPRGALIFYRRGVRRVNAKTGAEELYNLEGPINASVFPGHQGGPHNHTIAALAVALKQAQTPEFKSYQTQVLANAKALARRLGEPKEKGGLGYKIVSGGTDNHLVLVDLKPQGIDGARVERVLELVGVAANKNTVPGDKSALTPGGLRMGSPAMTTRGFTEEDFERVADIVDRAVTIAIRVDKAARKAAEEKGEGKTAGRLKTFLEYLGNGETDREIVQLRSEVADWVGTYPLPWDEGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0SA69</accession>
    <name>G0SA69_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative K(+)/H(+) antiporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0041200</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694526.1">
        <property type="nucleotide sequence ID" value="XM_006694463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SA69"/>
    <dbReference type="STRING" id="759272.G0SA69"/>
    <dbReference type="GeneID" id="18258158"/>
    <dbReference type="KEGG" id="cthr:CTHT_0041200"/>
    <dbReference type="eggNOG" id="KOG1650">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005126_10_0_1"/>
    <dbReference type="OMA" id="QVKVERW"/>
    <dbReference type="OrthoDB" id="2687058at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050794">
        <property type="entry name" value="CPA2_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32468">
        <property type="entry name" value="CATION/H + ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32468:SF0">
        <property type="entry name" value="K(+)_H(+) ANTIPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="9">
        <location>
            <begin position="44"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="836"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="842"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS19641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="893" mass="95681" checksum="528B37F5299B3599" modified="2011-10-19" version="1">MAGDVSGNGTGVPPQAGILEGVNPVQYSPGNPIALFIVQAAIVIIFCQLLHYPLRLINQPRVIAEVIGGILLGPTVMMRIPNFRETIFPPESMPVFNNVANLGLIVFLFLVDMRMFTQNWKAALSVGLAGMAIPFALGFGIAYGLYKEFHEGVAEKPIGFGVFGLFVGTALAITAFPVLCRILSELNLLRSSVGVTVLAAGIGNDVTGWVLLALCVALVNNSSGLSALWALLCCIGWTLLLVFVVRPPFMWLLRRTGSLQSGPTQGMVALTMLMVLASAWFTGAIGVHPIFGAFLAGLICPHDGGFAIKLTEKIEDLISVLFLPLYFALSGLNTNLGLLKDGLTWGYTIAVIIIAFVGKIAGGTLAAKLNKLLWRESFAIGSLMSCKGLVELIVLNIGLQAGILSETTFSMFVVMALVTTIATTPLTKALYPPWYQKKVERWRRGEIDWDGNPLVHSDSSHEDMPKKGEESQIRRLMVHLRLDSLPSLFTFITLLGSDPTRTSVHKEKDASGDSSSGQELPIKKRPLEVYGLRVIELTDRTSSVMHLTEGEDFYSQRDPVVNAFKTFSQLHDVAVSGRVAVVPTDSYAETLISQASDVSADFALIPWGEYGTVSEDQSFLMAASASERFRSSAHLDFINQTFQQAVRVCTTGIFIDNGFGGVTKPTTERPSLIRSKSNISIRSHHEPPALPAPHKDHHIFVPFFGGPDDRAALRLVFQLAKNQHVTVTVARIIWPVLKLQSQSTDGSGTRPATGTSIGAGTNDEVVQDEQDLALLTSIHSSLPADVASRIVVTEERVSSPTAAPTEVVALAQKSVGQRPKNAGDVVVLGRRNARLDESSVPGEVSAESGASSSTVGGGLDLKKTIGTVAEQLVAAGVKASVLVVQAGGKGLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAC6</accession>
    <name>G0SAC6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arsenite methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.137</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0041800</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>arsenic triglutathione + 2 [thioredoxin]-dithiol + 2 S-adenosyl-L-methionine + H2O = dimethylarsinous acid + 2 [thioredoxin]-disulfide + 3 glutathione + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:69464"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:23808"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:183640"/>
            <dbReference type="EC" id="2.1.1.137"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>arsenic triglutathione + 3 [thioredoxin]-dithiol + 3 S-adenosyl-L-methionine = trimethylarsine + 3 [thioredoxin]-disulfide + 3 glutathione + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:69432"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27130"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:183640"/>
            <dbReference type="EC" id="2.1.1.137"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>arsenic triglutathione + [thioredoxin]-dithiol + S-adenosyl-L-methionine + 2 H2O = methylarsonous acid + [thioredoxin]-disulfide + 3 glutathione + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69460"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17826"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:183640"/>
            <dbReference type="EC" id="2.1.1.137"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methyltransferase superfamily. Arsenite methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.137" evidence="4"/>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694583.1">
        <property type="nucleotide sequence ID" value="XM_006694520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAC6"/>
    <dbReference type="STRING" id="759272.G0SAC6"/>
    <dbReference type="GeneID" id="18258218"/>
    <dbReference type="KEGG" id="cthr:CTHT_0041800"/>
    <dbReference type="eggNOG" id="ENOG502QQD6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052868_3_1_1"/>
    <dbReference type="OMA" id="VNCISGA"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030791">
        <property type="term" value="F:arsenite methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026669">
        <property type="entry name" value="Arsenite_MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43675">
        <property type="entry name" value="ARSENITE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43675:SF8">
        <property type="entry name" value="ARSENITE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="9">
        <location>
            <begin position="66"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS19698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="352" mass="36945" checksum="A52F88D4B7283DB2" modified="2011-10-19" version="1">MATENTTTIYEEVRKHYSAASRSVSTKYGEAVAKSFGYTAEELAAIPAEANLGLSCGNPLAIASVKEGETIIDLGSGAGFDVFLAAKRVGANGKAIGVDMNDDMLERARKILESQPEEVKKVVSFVKSNITDMSSVLEDGVADCVISNCVINLVPAAEKPKVFKEMYRVLKHGGRVAVSDILAKQDLPEQLVKDVAMYVGCIAGASKVEEYETWLKEAGFKDVLIIDTKSDLNVYVEIGEDGEKKRSTEAKNDLCCGQNLQNCALIPAASEESGGCCGANKAEPAFQKQGEGCCKMSAGVSSSAGCCGAPSSSSPAPSGCCGVPVPAGLAESLSKTDLNEYVGSFKIYALKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAC8</accession>
    <name>G0SAC8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cyclin-dependent kinase 1</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Cell division protein kinase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CTHT_0041820</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Cyclin-dependent kinase that acts as a master regulator of the mitotic and meiotic cell cycles.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="17">Forms a stable but non-covalent complex with a regulatory subunit (SUC1) and with a cyclin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694585.1">
        <property type="nucleotide sequence ID" value="XM_006694522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAC8"/>
    <dbReference type="SMR" id="G0SAC8"/>
    <dbReference type="STRING" id="759272.G0SAC8"/>
    <dbReference type="GeneID" id="18258220"/>
    <dbReference type="KEGG" id="cthr:CTHT_0041820"/>
    <dbReference type="eggNOG" id="KOG0594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_6_1"/>
    <dbReference type="OMA" id="YLYQITR"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07835">
        <property type="entry name" value="STKc_CDK1_CdkB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000144">
        <property type="entry name" value="Cyclin-dependent kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000027">
        <property type="entry name" value="Putative Cyclin-dependent kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF254">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 21" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7 18 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 19" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="4"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00054329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00064036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EGS19700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="320" mass="36588" checksum="D9E55F42955AAAC6" modified="2011-10-19" version="1">MENYQKLEKIGEGTYGVVYKARDLANGGRIVALKKIRLEAEDEGVPSTAIREISLLKEMRDPNIVRLLNIVHAEGHKLYLVFEFLDLDLKKYMEALPVAEGGRGKSLPEGTNAELSRLGLGDQIIKKFMSQLCEGVRYCHSHRILHRDLKPQNLLIDREGNLKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGGRQYSTGVDMWSVGCIFAEMCTRKPLFPGDSEIDEIFKIFRLLGTPTEEIWPGVTSYPDFKPTFPKWVRDHSVPLIPNLDETGLDLLEMMLTYDPASRISAKQACNHPYFEDYPRPNYDRYHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAT2</accession>
    <name>G0SAT2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arylsulfatase</fullName>
            <shortName evidence="5">AS</shortName>
            <ecNumber evidence="5">3.1.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aryl-sulfate sulphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0047660</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an aryl sulfate + H2O = a phenol + sulfate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17261"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:33853"/>
            <dbReference type="ChEBI" id="CHEBI:140317"/>
            <dbReference type="EC" id="3.1.6.1"/>
        </reaction>
    </comment>
    <comment type="PTM">
        <text evidence="6">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="5"/>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695134.1">
        <property type="nucleotide sequence ID" value="XM_006695071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAT2"/>
    <dbReference type="STRING" id="759272.G0SAT2"/>
    <dbReference type="GeneID" id="18258804"/>
    <dbReference type="KEGG" id="cthr:CTHT_0047660"/>
    <dbReference type="eggNOG" id="KOG3731">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006332_4_0_1"/>
    <dbReference type="OMA" id="WCHGEHE"/>
    <dbReference type="OrthoDB" id="96314at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005539">
        <property type="term" value="F:glycosaminoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008449">
        <property type="term" value="F:N-acetylglucosamine-6-sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018958">
        <property type="term" value="P:phenol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16147">
        <property type="entry name" value="G6S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000051">
        <property type="entry name" value="Arylsulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012083">
        <property type="entry name" value="Arylsulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108:SF8">
        <property type="entry name" value="SD21168P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000972">
        <property type="entry name" value="Arylsulf_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409447" description="Arylsulfatase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="67"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="6">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000972-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS19312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="630" mass="72084" checksum="1A911100B6A1F444" modified="2011-10-19" version="1">MRYTGVAALAGLLLPQAQAGYYNDLHTQKTLVANHGKSYVDQIADGGYTDLTAEWERPAPGPNGKKPNIIFILTDDQDLHMNSLDYIPLIRKHLIEKGTLYTRHYCTTAICCPARVSLLTGRLAHNTNVTDVNPPHGGYPKFIKQGLNNDYLPVWLQQAGYDTYYTGKLFNAHTVENYNKPYPAGWNQSDFLLDPYTYMYLNATYQRNREPPKSYKGQHTVDVLAEKALGFIDIAAKNERPFFLGIAPVAPHSNVQSKLLDDIDESDPWKDIDDEDETLFSPPIPAERHKHLFPDAKVPRNPNFNPDVPSGANWVRKLPKLSDENVEFNDHFYRQRLRALQSVDELVEGVVERLEELGILDNTYIIYTTDNGYHISQHRLQPGKECGFEEDINVPLIIRGPGVPQNYVSEVITAHVDIAPTILNLAGAPSRADFDGERIPLSARELEEAKDKRHEHVTVEFWGIAAFEGKRFREDESRLQLNNTYKALRIIGKDYNFYYSVWCNNEHELYDLKTDPYQMNNLLHEDATPPPTLLGVEFDKVVARLDSLLFVLKSCKGQTCIKPWQALHPAGNVENLKDALHPRFDVFYQKQQKRVKYERCELGYIVDAEGPQFERDGLVYRHGVRWSEWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0SB04</accession>
    <name>G0SB04_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0048430</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695206.1">
        <property type="nucleotide sequence ID" value="XM_006695143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SB04"/>
    <dbReference type="GeneID" id="18258881"/>
    <dbReference type="KEGG" id="cthr:CTHT_0048430"/>
    <dbReference type="eggNOG" id="ENOG502S0C8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013866_4_0_1"/>
    <dbReference type="OMA" id="TIMSTDD"/>
    <dbReference type="OrthoDB" id="4314040at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF13">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS19384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="608" mass="66783" checksum="5E87305975AD568F" modified="2011-10-19" version="1">MVYLGKPSKGCGMCRQRRIKCDETKPTCNQCAKARRQCPGYRDEFDIVLRIENQAARRRALKLGSGRRRKNASTPSSTSSDDASSSSSSSPPSSTSSISGPRTQLTPTERNLSLTQQLQRRTPPPSVPANLSLPLEEVARCHFMANFVLLPGKNGSHGFMEYLIPLLAESPPLSLLPPSPPASLSSRSSSPTATTINPYVPFQHAFNACALAWLGNRVGRRTLLPSPVPSPPPHLSAEERATTPGQLIGRAFGEYARALRAMQTLLKHDPQRAAASDAVLASVLLLEWWMSAGIVDSTAAECQRLNLETGELRAEATRVMAAAVERTPATTAYVQSILERAKQLDARVAEWMRNVPFEWRYETIWPENIRPLGGMSMADLACAEVFPDLRRGVDVYRDFSTAASWNLARTTRLILWSIAVRCAAWIGMPQVRDWRQTEEYLQAKDVASNMVADIIASVPYHLRWKGINCKQDLGFAVGNDDAPGVRGLGAYFLTWPLACVMTQDYATEEQRAYVRGRLNYIGDECGIKYAHILAQLNFRIPSMLIRSDGLMAKPFPKAYDFEKLVSAPPPQAHSMLVGQAAAPGEQTQDRLAALAAMAVGQMGPTEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBF4</accession>
    <name>G0SBF4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Adenine DNA glycosylase</fullName>
            <ecNumber evidence="3 13">3.2.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CTHT_0050080</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Adenine glycosylase active on G-A mispairs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.</text>
            <dbReference type="EC" id="3.2.2.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.31" evidence="3 13"/>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695356.1">
        <property type="nucleotide sequence ID" value="XM_006695293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBF4"/>
    <dbReference type="STRING" id="759272.G0SBF4"/>
    <dbReference type="GeneID" id="18259046"/>
    <dbReference type="KEGG" id="cthr:CTHT_0050080"/>
    <dbReference type="eggNOG" id="KOG2457">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012862_0_0_1"/>
    <dbReference type="OMA" id="CRPGDFN"/>
    <dbReference type="OrthoDB" id="10248838at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035485">
        <property type="term" value="F:adenine/guanine mispair binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032357">
        <property type="term" value="F:oxidized purine DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000701">
        <property type="term" value="F:purine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03431">
        <property type="entry name" value="NUDIX_DNA_Glycosylase_C-MutY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000002">
        <property type="entry name" value="Adenine DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044298">
        <property type="entry name" value="MIG/MutY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029119">
        <property type="entry name" value="MutY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944">
        <property type="entry name" value="ADENINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944:SF1">
        <property type="entry name" value="ADENINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14815">
        <property type="entry name" value="NUDIX_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="15">
        <location>
            <begin position="192"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="39"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="408"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGS19534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="638" mass="71557" checksum="D78333B697FE99CB" modified="2011-10-19" version="1">MTTRRSARIASKRQYPQTEEADIFPASKKKCTNANALFNNDTDAASSDGPELLSFRTASDSELSPPTSLDFQHSSPDVRSSKRRKKQPRFKSSKKSPSKSTDLNRILQAILSPPHPLSPRVPSHRTPHPMSYHHPKLLSSKYARESLLQWFDSRVASQTRPMPWRKPFLLPSTTPPADIERRAYEVWISETMLQQTRVSTVIPYWEKWISKWPTAGDLARAEKDEVLSVWRGLGYYARARRLLEAAKAVCAPGKQEGERLPRNVEGWLGLPGVGRYTAGAVTAITFGVPAAMVDGNVLRVLSRQMGIYGDVKGDRRVVELVWRVAEELVKVVSREGSQEPNDRPGRWGQALMELGSTLCMPRPECGRCPISVTCRVYEEGLAIAEGNGTKGVVGDIEDGCELCQPFEEGEEDGKDVEENEQPTRANQSKMQQTLSRFFAPKDTNVTDTVSARTLGVIISHAKKFPYRPPKKTIRAEETLVCVIRRSDCRYLIQRRPDKGLLAGMWEFPSQTLNDSNKTAKSRKARAAGFVKDNILNEKRKVSVSIRHVGELGTVPWQFSHLSLTMHVHLFELNEAGLDDNLVGGRRWATIEEIEQENMGTGMRKCWTLNPFGMFKSSKMACKRNSSATVLVESIPYGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBG4</accession>
    <name>G0SBG4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0050180</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695366.1">
        <property type="nucleotide sequence ID" value="XM_006695303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBG4"/>
    <dbReference type="GeneID" id="18259056"/>
    <dbReference type="KEGG" id="cthr:CTHT_0050180"/>
    <dbReference type="HOGENOM" id="CLU_1916838_0_0_1"/>
    <dbReference type="OrthoDB" id="4590717at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408992" evidence="1">
        <location>
            <begin position="23"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="132" mass="12792" checksum="97FDD7D4300922D0" modified="2011-10-19" version="1">MVLVKIALIFFLAYALLPVTFGQVTITVPSGATLPSGATLPSGVSVVTAGATTNTVQGNANRRQVTITVPSGATSPSGVTLPSGVSVVTAAGTTAAAERRQVTVTIPSGASIPSGVTLPSGVSVVTAGATSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBP3</accession>
    <name>G0SBP3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Inorganic pyrophosphatase</fullName>
            <ecNumber evidence="4">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Pyrophosphate phospho-hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0054290</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>diphosphate + H2O = 2 phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="4"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695764.1">
        <property type="nucleotide sequence ID" value="XM_006695701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBP3"/>
    <dbReference type="STRING" id="759272.G0SBP3"/>
    <dbReference type="GeneID" id="18259467"/>
    <dbReference type="KEGG" id="cthr:CTHT_0054290"/>
    <dbReference type="eggNOG" id="KOG1626">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040684_0_1_1"/>
    <dbReference type="OMA" id="LYANEQK"/>
    <dbReference type="OrthoDB" id="1608002at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.80.10:FF:000004">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="INORGANIC PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00387">
        <property type="entry name" value="PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="64"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS18819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="386" mass="42396" checksum="99A0A174F85A8A34" modified="2011-10-19" version="1">MPQSSLCPGQSQSRPLASLASPTSSLSYPAAGAPPPRFPSVATAAASSISTSASAANPARAQLRTASSRSAQIARHLSSSSLSQTQPARSYNTDTKMSSPYTIRKVGQPNTIDHRVYIEKDGVPISPFHDIPLYANPEGTILNMIVEIPRWTNAKLEISKDELLNPIKQDTKKGKLRYVRNCFPHKGYLWNYGAFPQTWEDPNSIHPETKAKGDNDPLDVCEIGELVGYTGQVKQVKVLGVMALLDEEETDWKVIVIDVNDPLAPKLNDVEDVERHLPGLLRATNEWFRIYKIPDGKPENQFAFTGECKNKKYAMDVIRECNEAWERLITGKTPAGNISTANLTVAHSASRISSEQLPPLPQNQELPPAPIDPSIDKWFFISGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBW1</accession>
    <name>G0SBW1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0054990</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FRG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695832.1">
        <property type="nucleotide sequence ID" value="XM_006695769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBW1"/>
    <dbReference type="STRING" id="759272.G0SBW1"/>
    <dbReference type="GeneID" id="18259537"/>
    <dbReference type="KEGG" id="cthr:CTHT_0054990"/>
    <dbReference type="eggNOG" id="KOG3962">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062276_2_0_1"/>
    <dbReference type="OMA" id="ACDVNGK"/>
    <dbReference type="OrthoDB" id="5539371at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23339">
        <property type="entry name" value="beta-trefoil_FSCN_fungal_FRG1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008999">
        <property type="entry name" value="Actin-crosslinking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010414">
        <property type="entry name" value="FRG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928">
        <property type="entry name" value="FRG1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928:SF0">
        <property type="entry name" value="FSHD REGION GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06229">
        <property type="entry name" value="FRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50405">
        <property type="entry name" value="Actin-crosslinking proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS18887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="265" mass="29780" checksum="94CC945A142F08DF" modified="2011-10-19" version="1">MVKPLTFKGDKKPKKRKRAVNDDDTGREVKAAKPSADTVDVEPEADDSWVSADVPSDISGPVMLVLPTEPPSALACDANGKVFTIVIENIIDGNPSSAEPHDVRQVWVANKIPGTEHFRYLSCDKIGVLSATADAVSPLETWDIISTPSTPGTFQLQTQRDTFVTVRETPNSKKQQYEVRGDETDVTFHTTLRIRMQARFKPRVQKSKEEKALKERVISRRELEEAAGRKLTDEEVKMLRRARKEGDYHEKLLDIKVKSKHDKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0SC27</accession>
    <name>G0SC27_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Lactose permease-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0055680</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695898.1">
        <property type="nucleotide sequence ID" value="XM_006695835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SC27"/>
    <dbReference type="GeneID" id="18259606"/>
    <dbReference type="KEGG" id="cthr:CTHT_0055680"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="OMA" id="RWRFLQV"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000217">
        <property type="entry name" value="MFS lactose permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF36">
        <property type="entry name" value="LACTOSE PERMEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="487"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="68"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS18953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="550" mass="60523" checksum="9A60FF33057FC3A1" modified="2011-10-19" version="1">MSSSASKENIHKEKQAAAPTVTTTAVPASKAPSKGKKEKEVHNAELYAAIQEANINPWSWTSIHLYFAIFISFCCAVANGYDGSLMTSIIAMRHFVEVFKPKEGTNESVIFSLYTVGAMVGAPFAATLSDKFGRRKAMFCGGAVIIIGMIIISTAMKFAQLVVGRFVLGLGIAIMTVAAPAYSIEIAPPHWRGRCTGFYNCGWFGGSIPAAIVTFATNYIDNHYSWRIPLILQAFACVIVMIGVFFIPESPRYLMANGRDEEAFAFLVKYHGNGDPNSRLVRLEIEEMREGIRQDGIDKVWWDYRPLFLTHNGRWRMAQVLMISIFGQFSGNGLGYFNTTIFNNLGVDSIPAQLGYNILNQGLSAFGALTAVSLTDRMPRRKVLVIGTFMCALALATNAGLSEKMAQLDAKGLFSASYGKGALASYFLFNIIYSFTYTPLQGVIPTEALETTMRAKGLALSGFIVNAVGFINQFAGPIGLKNIKHRYIFVFVGWDVIEAIAWYLFGVESQGRTLEQLEWVYNQPNPVKASLKVDKVVVDEEGKVTEKLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0SC88</accession>
    <name>G0SC88_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Adipor-like receptor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0056340</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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                <person name="Kunze R."/>
                <person name="Devos D.P."/>
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            <title>High-resolution structures of a thermophilic eukaryotic 80S ribosome reveal atomistic details of translocation.</title>
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                <person name="Wild K."/>
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                <person name="Lau B."/>
                <person name="Huang Z."/>
                <person name="Kellner N."/>
                <person name="Niu S."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
                <person name="Cheng J."/>
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        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e57984" last="e57984">
            <title>Structural insights into coordinating 5S RNP rotation with ITS2 pre-RNA processing during ribosome formation.</title>
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                <person name="Lau B."/>
                <person name="Cheng J."/>
                <person name="Fromm L."/>
                <person name="Denk T."/>
                <person name="Kellner N."/>
                <person name="Flemming D."/>
                <person name="Fischer P."/>
                <person name="Falquet L."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
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        <citation type="journal article" date="2023" name="Nat. Struct. Mol. Biol." volume="30" first="670" last="677">
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    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.190:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.190">
        <property type="entry name" value="translation elongation factor selb, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00573">
        <property type="entry name" value="Ribosomal_eL33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001780">
        <property type="entry name" value="Ribosomal_eL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018266">
        <property type="entry name" value="Ribosomal_eL33_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038661">
        <property type="entry name" value="Ribosomal_eL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10902">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01247">
        <property type="entry name" value="Ribosomal_L35Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01105">
        <property type="entry name" value="RIBOSOMAL_L35AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6 7 8" id="KW-0002">3D-structure</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS19139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="7OLC"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="7OLD"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="7Z3N"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="7Z3O"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="8I9P"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="8I9R"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="8I9T"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="8OO0"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="8PV1"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="8PV2"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="8PV3"/>
        </source>
    </evidence>
    <sequence length="109" mass="12304" checksum="AD98B618F0B9852A" modified="2011-10-19" version="1">MPSEAGHRLYVKGRHLSYQRGRRNTHPKTSLIKIEGVDDTAAANFYLGKRVAYVYRAQKEVRGTKIRVIWGKITRPHGNSGVVRAKFTHPLPARSFGASVRIMLYPSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCT6</accession>
    <name>G0SCT6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0058370</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + nicotinate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAPRTase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="3"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696157.1">
        <property type="nucleotide sequence ID" value="XM_006696094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCT6"/>
    <dbReference type="STRING" id="759272.G0SCT6"/>
    <dbReference type="GeneID" id="18259875"/>
    <dbReference type="KEGG" id="cthr:CTHT_0058370"/>
    <dbReference type="eggNOG" id="KOG2511">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030991_0_0_1"/>
    <dbReference type="OMA" id="IEHCLEY"/>
    <dbReference type="OrthoDB" id="193380at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034355">
        <property type="term" value="P:NAD+ biosynthetic process via the salvage pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01401">
        <property type="entry name" value="PncB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.140.10">
        <property type="entry name" value="nicotinate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006406">
        <property type="entry name" value="Nic_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098:SF1">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nicotinate phosphoribosyltransferase N-terminal" evidence="9">
        <location>
            <begin position="17"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Nicotinate/nicotinamide phosphoribosyltransferase" evidence="8">
        <location>
            <begin position="183"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Nicotinate/nicotinamide phosphoribosyltransferase" evidence="8">
        <location>
            <begin position="327"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS19212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="484" mass="54573" checksum="126C547B41A52019" modified="2011-10-19" version="1">MDFNSSSPYPEGVISFLDTDLYKLTMQCAVLKYYKDVPVTYSFTNRTPEKKLSRKAFRWLEEQILKLGNISLSNEELDYLKRHCPYLSSEYLEYLSEFRLRPRDQVVVKFLPVSEDTGADTDIGDMDIHINGTWAETILYEIPLLALTSEAYFKFMEPDWTYEGQEERAYEKGMRLLEAGCVFSEFGTRRRRDYHTQALVFRGLIRAAREAEKRGYTGKLSGTSNVHLAMRFNIPPVGTVAHEWFMGTAAVVGDYRAATEEALCRWVSCFGEGVLGIALTDTFGTPEFLNAFSKPVRYLGEPVPTATDRKPSIADTFISASSSTASKEKKAKKTYAEVFTGVRQDSGDPKSFVKLIREFYDSQGITDKKVIVFSDSLNIERCLEYKQVAEEACFQPTFGVGTYLTNDFTNTKTGKKSTPLNIVIKISSAAGRPAVKISDNIGKNTGDKATVEKVKRELGYVEQSWAEGDETARWGREDDVPSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0SD08</accession>
    <name>G0SD08_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF829-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0050350</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695383.1">
        <property type="nucleotide sequence ID" value="XM_006695320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SD08"/>
    <dbReference type="GeneID" id="18259073"/>
    <dbReference type="KEGG" id="cthr:CTHT_0050350"/>
    <dbReference type="eggNOG" id="ENOG502SJWV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036503_0_0_1"/>
    <dbReference type="OMA" id="GDGMPKH"/>
    <dbReference type="OrthoDB" id="77878at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008547">
        <property type="entry name" value="DUF829_TMEM53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265:SF14">
        <property type="entry name" value="INDOLE-DITERPENE BIOSYNTHESIS PROTEIN PAXU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05705">
        <property type="entry name" value="DUF829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="33509" checksum="368A816A1E6CEDF8" modified="2011-10-19" version="1">MTSKQLVVAESLLTGFQKLSSQVYVRQGDPGSPDSSHPTTIIIYGWGDARPKHVVKYVDGYHRLYPHACIVLIFSPILKTLYQTLESRSRTMIPVIQAVYPDVLDTKIEKSRELKRVLLHVMSNTGGMNCAATMNAYHKLTGGHVFPHDMLVCDSTPGSTAFLPNVGPWSRAMTLGASSWLPWPFFVTQALAAIFLGCLHGFGWLIGATSAAEWSTNAVNDPKMSDTSAKRLYLYSKEDDIIHWADIEKHAADARQKGWSVSAELFEGTPHVGHMRAHPEQYWNAIAKAWEEVVSNKIRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G0SD33</accession>
    <name>G0SD33_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0050650</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006695345.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="18259103"/>
    <dbReference type="KEGG" id="cthr:CTHT_0050650"/>
    <dbReference type="HOGENOM" id="CLU_407678_0_0_1"/>
    <dbReference type="OMA" id="SICEYRT"/>
    <dbReference type="OrthoDB" id="4591016at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="632"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="652"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="674" mass="69498" checksum="1FA57D30EEA4B508" modified="2011-10-19" version="1">MASNAPAERQPAQYTPYRPGARLTQQAQQKCQSPHDGPQREYKPLQPPEQGLVSSMAGLAISNTGPAQIQGAATPNSVPEFGTAGSRRSLRVIQPYRLPGKSESAQVAPNSLPTTPAPSQSVAKPTAANQANITASVQQPLSNNGHSFPNPPQTNEPSSTALGQDSQSQATTTTALACDTLQTPGPIPVLPPWKVNVNPYLNTQAQSSLVPKSPRPAYPDHEGLIPVEKPAPPDHEGLIPVDSELEFSSPLFPNQSVTSPLSPSQPTDNQNISQYSPTATSSQPTVTQCAQQTQQPTSLPINNPHPQVNQITGQYPPVTAPSPPPVMQPGQVSSQQTQPAIVAPVPKPPHPQPSDGLSSPSTPSLGQTPVTPSSPPPPYSPPLQSPPQYPGSTGSVAVPPATIACATQGHAPVTQVSSGPYLAAVASPAPGPNPPPLPPRPATQPHVYPTTQSQLPTINVPTISVPQTPMGAQPLSPHPGTQPAPMFPAPTPQAAAVGPYAPVAVSPRPGTTTPQPMAIPQTIPPPPQSTSHLNAYPVSKPSVIPIIPSVSGSMSPARPATALGHIASSVLNRPDKWSKKTASFLGEAIKFAAATAEEAMQVAGVHRHKSLSARSPPTYNYALVPVPGFPGPQPQPWPAPVPGTPMSPVVPGPAAGAPSVPGVPGAPGPMMPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0SD67</accession>
    <name>G0SD67_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative bud site selection protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0059130</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006696169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SD67"/>
    <dbReference type="STRING" id="759272.G0SD67"/>
    <dbReference type="GeneID" id="18259951"/>
    <dbReference type="KEGG" id="cthr:CTHT_0059130"/>
    <dbReference type="eggNOG" id="ENOG502QRI8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029881_1_1_1"/>
    <dbReference type="OMA" id="WAPIREP"/>
    <dbReference type="OrthoDB" id="5584247at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052246">
        <property type="entry name" value="Cell_Polariz_PKAAnc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155:SF1">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155">
        <property type="entry name" value="A-KINASE ANCHOR PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="177"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS19287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="370" mass="41641" checksum="A6920C898987E133" modified="2011-10-19" version="1">MSSRSASAASRAAGTPPPQPEAPRNRLPTLFEVLSRRTLAPVDLFSFYIYMRDQQRSVDYLDFWLDIAQHMSLCRHYVRELRRSVLLETPDPEQASKRSSGILEALGEMSHPVAAPAHYITEKEREQDAQMSAFLREENPAFQHSPPGSSGGHDRLSPTGSHSHRLNGSSSPAHTVSRQDIRASAEKILYTYLMPGAEREIILPGSITQDITVAVEEHGRDDPEVFDVAKDYVFQAMERDAFPGFLRMKGFGNLIPSTMIMRLIIGLISMFGAFWAAFILIFLDKDRETRLWLILPFTIGVYCLSAYQYSLDPILAIIGLSEYTPFHFVRIQEPYVRNLLIRRAIVAFVVALLADAALCVLFVLVPGKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDT1</accession>
    <name>G0SDT1_CHATD</name>
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        <recommendedName>
            <fullName evidence="5">ER membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0052890</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006695564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDT1"/>
    <dbReference type="STRING" id="759272.G0SDT1"/>
    <dbReference type="GeneID" id="18259327"/>
    <dbReference type="KEGG" id="cthr:CTHT_0052890"/>
    <dbReference type="eggNOG" id="ENOG502QRTT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027878_1_0_1"/>
    <dbReference type="OMA" id="TTPDRSW"/>
    <dbReference type="OrthoDB" id="5577218at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048309">
        <property type="term" value="P:endoplasmic reticulum inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013635">
        <property type="entry name" value="Ice2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31726">
        <property type="entry name" value="PROTEIN ICE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31726:SF2">
        <property type="entry name" value="PROTEIN ICE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08426">
        <property type="entry name" value="ICE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409049" description="ER membrane protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS18682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="47419" checksum="5247FAA003791012" modified="2011-10-19" version="1">MWWLISACSSAIFLLSIVLSIPISFDVGGRDAGLAYSLSLFLFYLFYSTSKLLTPEKSRVRWLITHLIGLSQWVVIPALLIWSLDRFSVDAGSANWVTRTFSHLTGRHKTWKEWFFGQEGFLETVALGAWDSTLSYSSPVFQLLEGFCSLLVIQAAGQITRWLVNRGRSDTWVVGSVISSALYFLWRVISFPQINKFDATLIGIAMTTALFLCAYGIASGRGNPVESSLLFAYTVLCVYQIFTDYQPSPEAAAAAEQAAAAQPDFPPLPPIIMASYSTLMHILGSLPTAVNSAFQFLYAAFQTITPSVIISLTYRTIVFYCATRIIPAVRELGARAILEDPSLEDSEDSDAANRLLGFLSWFSPSMLIALYTSLLLQHFSVSADDAGWTLRAGDVGGSTWRWVNIAATMGLYAVELYLGGDGDGGAHWKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0SE53</accession>
    <name>G0SE53_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tetratricopeptide SHNi-TPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0062470</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696561.1">
        <property type="nucleotide sequence ID" value="XM_006696498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SE53"/>
    <dbReference type="STRING" id="759272.G0SE53"/>
    <dbReference type="GeneID" id="18260285"/>
    <dbReference type="KEGG" id="cthr:CTHT_0062470"/>
    <dbReference type="eggNOG" id="KOG4563">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028900_1_0_1"/>
    <dbReference type="OMA" id="IAECHYK"/>
    <dbReference type="OrthoDB" id="5587616at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001111">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051730">
        <property type="entry name" value="NASP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019544">
        <property type="entry name" value="Tetratricopeptide_SHNi-TPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081:SF1">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN NASP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10516">
        <property type="entry name" value="SHNi-TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Tetratricopeptide SHNi-TPR" evidence="5">
        <location>
            <begin position="244"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="92"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="424"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="330"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="445"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS18230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="455" mass="49334" checksum="582D9EFD9D10761F" modified="2011-10-19" version="1">MATPTAQSGNATPACELDPEETKKSLNVSLADLCAKATALYAKKKYEEAAEVFAQAAEMQAEMNGEMNPENAEILFLYGRALFKVGQAKSDVLGGKAPDAKKPVSKAKPEKQTGSYAAAESSKAAEKKQNGGSATAEVPAAKKGLFQFEGDQDFDDSEEDEEEGDEEEEEEEDDLAVAFEVLDLARVLLNKKLEALQAEQATKEIEAQEQAGKGKEVAVEITETPGETLASEPATIRHIKERLADTHDLLAEISLENERYHNAITDSRASLKYKQELYPFESEIIAEAHFKLSLALEFASVTKNPDDEASSSSAAVQKQGYDPALRAEAAAELEKAIESTKLKLQNKEVELATLHNPEDNETTRRQIADVKEVLADMEQRLIDLKKPPIDLNAALGMPPAGSSSSVTKVSEDVAKNATDLTGLVRKKNKRKAEEPEETVAAAEGIEAKKPREEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0SE85</accession>
    <name>G0SE85_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0062850</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="3650" last="3650">
            <title>Structural mechanism of protein recognition by the FW domain of autophagy receptor Nbr1.</title>
            <authorList>
                <person name="Zhang J."/>
                <person name="Wang Y.Y."/>
                <person name="Pan Z.Q."/>
                <person name="Li Y."/>
                <person name="Sui J."/>
                <person name="Du L.L."/>
                <person name="Ye K."/>
            </authorList>
            <dbReference type="DOI" id="10.1038/s41467-022-31439-5"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.19 ANGSTROMS) OF 606-746</scope>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696593.1">
        <property type="nucleotide sequence ID" value="XM_006696530.1"/>
    </dbReference>
    <dbReference type="PDB" id="7VQO">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.19 A"/>
        <property type="chains" value="A/B/C/D=606-746"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SE85"/>
    <dbReference type="SMR" id="G0SE85"/>
    <dbReference type="STRING" id="759272.G0SE85"/>
    <dbReference type="GeneID" id="18260323"/>
    <dbReference type="KEGG" id="cthr:CTHT_0062850"/>
    <dbReference type="eggNOG" id="KOG4351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4582">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007590_0_0_1"/>
    <dbReference type="OMA" id="NKHGHHP"/>
    <dbReference type="OrthoDB" id="661148at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14947">
        <property type="entry name" value="NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02249">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02340">
        <property type="entry name" value="ZZ_NBR1_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032350">
        <property type="entry name" value="Nbr1_FW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930">
        <property type="entry name" value="OVARIAN CARCINOMA ANTIGEN CA125-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930:SF0">
        <property type="entry name" value="PROTEIN ILRUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16158">
        <property type="entry name" value="N_BRCA1_IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9" id="KW-0002">3D-structure</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="470"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="93"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="265"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="537"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="743"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="835"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="162"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="282"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="540"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="776"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS18262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="7VQO"/>
        </source>
    </evidence>
    <sequence length="854" mass="93740" checksum="7A5D01999CD56A29" modified="2011-10-19" version="1">MATPAVQVTPDTLITFKVSLDGSPRRFKLPLRDVGINVLEGKLRAALNIPPEVDAVFERFSDSAAAFVVLDQNKPAVYKQLYRAAKAKQKLKLRVTTKKPEEANNKPQPAAVEDAPEQEAQQPVESVPAPEREADSATAENIASAPERPASPMPEEKQVEITQAAAEQSTTETNSAIESFGEKLKTSTEYLREVLNEASTAPAAAPEQLPPVPAPAPAAVPLPCRVDCPPLRSHYAECVDRGVTCKGADHWMIKRFVRDGVIINSTTERLPPKTKPAPTETPKPATTSASPPRTFPTGPAAPVTSVTPPIAPPVPTMTSERIIPVFNDFLYSSMRTCNCCVRDFPEVAFVHCTTCEDYDLCRSCFAKNRHGHHPGHAFVPAVEGTRLEPEVARLLAPGRGVIHNALCDGCDNTIRGVRHKCLNCPDWDYCSQCILNAPVIHPGHRFVPIYEPLEQADSNANFRFQSRPVHFGICCDGPLCNNGPNSNRYIVGDRYKCAVCHDTDFCEACEASPANTHNKTHPLIKFKTPVRHVSVTTTGENEHGRQMPPMGDRRVPRPRAPESAPHQCPAPSNVGNVQTVVDVKPIEPEVPVKEEKVEEKVEKKPEPVVEKEPSAEELEATFVRDTVQDGTVLAPNHLFEQTWVLRNTGKVAWPAGCSVKFVGGDYMGRVDSAHPAASKEVEESCESTVCDRAVQPGEEAPFTVLLRTPYRACRVISHWRLTTPKGTKFGHRLWCDVVVEKPKSRSPSPAPAFVEEKAKEVSPEPEPATSQMIFPKLDRESPVMSVHEEEARSEGVPTSVAVPSIQDEFEDCEDVDWPENGSEDGFLTDEEYDVLDASDEEFSMGLHPSTSKQK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-06-24" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEA3</accession>
    <accession>G0ZGV3</accession>
    <name>GLE2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mRNA export factor GLE2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Nuclear pore protein GLE2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Nucleoporin GLE2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">GLE2</name>
        <name type="ORF">CTHT_0063040</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. It is specifically important for nuclear mRNA export.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 5">Component of the nuclear pore complex (NPC). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Nucleoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="1">Symmetric distribution.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat rae1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JF276298">
        <property type="protein sequence ID" value="AEL00691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696611.1">
        <property type="nucleotide sequence ID" value="XM_006696548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEA3"/>
    <dbReference type="SMR" id="G0SEA3"/>
    <dbReference type="STRING" id="759272.G0SEA3"/>
    <dbReference type="TCDB" id="1.I.1.1.2">
        <property type="family name" value="the nuclear pore complex (npc) family"/>
    </dbReference>
    <dbReference type="GeneID" id="18260342"/>
    <dbReference type="KEGG" id="cthr:CTHT_0063040"/>
    <dbReference type="eggNOG" id="KOG0647">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038526_1_0_1"/>
    <dbReference type="OMA" id="EAMDQSI"/>
    <dbReference type="OrthoDB" id="256303at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000190">
        <property type="entry name" value="Nuclear pore complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0509">mRNA transport</keyword>
    <keyword id="KW-0906">Nuclear pore complex</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0853">WD repeat</keyword>
    <feature type="chain" id="PRO_0000433190" description="mRNA export factor GLE2">
        <location>
            <begin position="1"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 1" evidence="2">
        <location>
            <begin position="28"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 2" evidence="2">
        <location>
            <begin position="76"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 3" evidence="2">
        <location>
            <begin position="117"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 4" evidence="2">
        <location>
            <begin position="160"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 5" evidence="2">
        <location>
            <begin position="256"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P40066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000305" key="5">
        <source>
            <dbReference type="PubMed" id="21784248"/>
        </source>
    </evidence>
    <sequence length="357" mass="39411" checksum="10B48D9A61EC99EF" modified="2011-10-19" version="1">MAGLFGTTTSTTTSTLGDLKNDVELGSPPEDSITDLSFNPNPNDPKDFLAVSSWDKKVRVYEIAANGQNQGKVQMEHEGPVFAVDFFKDGTKVISAGADKQAKVLDLASGQAMQVAAHDAPIRCVKYFEAGGTPMAVTGSWDKTIKYWDFRSATPAGTVQCQERVYTMDVKENLLVIGTADRYIDVINLKEPVKFYKTLQSPLKWQTRVVSCFTDSQGFAIGSIEGRCAIQYVEDKDQSMNFSFKCHRDTPQNNVTNVHAVNAISFHPQHGTFSTAGSDGTFHFWDKDAKHRLKGYPNVGGSITATKFNRNGTIFAYAISYDWSKGYQGNTANYPTKVMLHPVLGDECKPRPSVKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEE1</accession>
    <name>G0SEE1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0063420</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins. Involved in mitophagy. Required for the switch to necrotrophic growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The mitochondrial prohibitin complex consists of two subunits (PHB1 and PHB2). The subunits assemble into a membrane-associated ring-shaped supercomplex of approximately 1 mDa. Interacts with ATG24/SNX4; the interaction is direct and plays a role in mitophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prohibitin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696649.1">
        <property type="nucleotide sequence ID" value="XM_006696586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEE1"/>
    <dbReference type="STRING" id="759272.G0SEE1"/>
    <dbReference type="GeneID" id="18260380"/>
    <dbReference type="KEGG" id="cthr:CTHT_0063420"/>
    <dbReference type="eggNOG" id="KOG3083">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047969_0_2_1"/>
    <dbReference type="OMA" id="YEFRLVT"/>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035632">
        <property type="term" value="C:mitochondrial prohibitin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF0">
        <property type="entry name" value="PROHIBITIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="5">
        <location>
            <begin position="26"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00053189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00066275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS18318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="276" mass="30523" checksum="5FC4FE9CC8493DC6" modified="2011-10-19" version="1">MAARGLNFIYQAAVPAAVGVGLLQASMYDVKGGTRAVIFDRLSGVKEQVVNEGTHFLIPWLQKAIIFDVRTKPRIIPTTTGSKDLQMVSLTLRVLHRPEVQALPKIYQNLGTDYDERVLPSIGNEVLKAIVAQYDAAELITQREVVSQRIRHDLTKRAREFNIALEDVSITHLTFGKEFTKAVEQKQIAQQDAERARFIVERAEQERQANVIRAEGEAEAAETISKAIAKAGDGLIQIRRLEASREIAQTLANNPNVVYLPGGNKGANLLMSVGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0SER1</accession>
    <name>G0SER1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">VPS37 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0059390</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS37 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS17927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696258.1">
        <property type="nucleotide sequence ID" value="XM_006696195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SER1"/>
    <dbReference type="GeneID" id="18259977"/>
    <dbReference type="KEGG" id="cthr:CTHT_0059390"/>
    <dbReference type="eggNOG" id="ENOG502S268">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088665_0_0_1"/>
    <dbReference type="OMA" id="SWRKKQT"/>
    <dbReference type="OrthoDB" id="10260857at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009851">
        <property type="entry name" value="Mod_r"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678:SF2">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07200">
        <property type="entry name" value="Mod_r"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51314">
        <property type="entry name" value="VPS37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS37 C-terminal" evidence="8">
        <location>
            <begin position="171"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS17927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="271" mass="29496" checksum="4482077CD74953F5" modified="2011-10-19" version="1">MDAHAPPAPPPKPPGSHEASWISTPAGPLLPRPPPPPPDVIAESLNSTDSGNGIATAVASVASQQQQQQQQQHIGHSPDELEDPGEQWLPKFLQDKSKQDLAAILSNPSLLSALTHSPSTIHPSLQASHSALQTALAENVALASQLLELEARVTQQRSTTQAQLLATHALERQWRAKQSAMDHALAPFAPASLYQRLAQSVLEQEAVCKALEESFLEGEPGSGSGNGDESGVATEKEVMDWVKRYREAKKLYYLRQERKERWDEGRVGGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEX4</accession>
    <name>G0SEX4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nuclear localization protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0060030</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS17990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696321.1">
        <property type="nucleotide sequence ID" value="XM_006696258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEX4"/>
    <dbReference type="STRING" id="759272.G0SEX4"/>
    <dbReference type="GeneID" id="18260041"/>
    <dbReference type="KEGG" id="cthr:CTHT_0060030"/>
    <dbReference type="eggNOG" id="ENOG502R38T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013061_2_0_1"/>
    <dbReference type="OrthoDB" id="5598844at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013933">
        <property type="entry name" value="CRC_Rsc7/Swp82"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597:SF5">
        <property type="entry name" value="LOCALIZATION PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08624">
        <property type="entry name" value="CRC_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="270"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="419"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="478"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="288"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
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        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
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        <location>
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    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="582"/>
            <end position="592"/>
        </location>
    </feature>
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        <location>
            <begin position="605"/>
            <end position="615"/>
        </location>
    </feature>
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        <location>
            <begin position="616"/>
            <end position="632"/>
        </location>
    </feature>
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        <location>
            <begin position="663"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS17990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="714" mass="75114" checksum="C1F1E01361880E6D" modified="2011-10-19" version="1">MYAAPPNGVEGATINPAALNSADPLALSRGLKRSRSPDDFADTGPNGPAGDDGGDKPRKRGRPMKPLPSGTATASLPPVPSAPQNAPPQTPQNQNATLPVQTPSSYTTTTAQASPPKPAPSKPLKALPTVRDHTTDILAPSGDEYLVREIDEAGEKKVLPNGQLLGGRQYKCRTFCVPNRGDKLFMLATECARVLGYRDSYLLFNKNRSLYKIIANQAEKDDLVAQEILPFSYRSRQIAIVTARSMFRQFGSRMIVNGRRVRDDYWESKARKQGFTEDDPAGEKRPGASRARAAAEASHAASLMAAPHGEIVYSTSQFGPQPPLVPPGMLGGPATTRPSMITLGPDYSDTRSRDYSSILKNGPRQEITGPPYQDRIQPTPLTELHAQAHHAAEFNRTLNQQREMRADYMNSIWRRPHEQPVPPALPAPVSAPDPVVPPAVPPSRTSAATHTSSLQPPAILPNQSPQLMMTAAPYSQSIHAPNPVASQGSLRAGMAHHRSVPQATFQQAARGPTHHSSATGSTTTASLAPAPAPAQPNYTYSQSAAAAPNQMWPPAPQTPQHGAPGAGPAPGAPSPYSAYTTAPAQPHQSTPGNAGGPGTPQLRHGSAPSAAAPAPGSNPAPTGAPAPGPSPLAPYSGLPGMPGQGYGPVYGAEQTPRGYMHHQTWNTGPGQGQGQQNQQQGQQQPGQQGQGQGQQTQPQPAAVAAGGWWGGQGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFE1</accession>
    <name>G0SFE1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0061720</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696488.1">
        <property type="nucleotide sequence ID" value="XM_006696425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFE1"/>
    <dbReference type="STRING" id="759272.G0SFE1"/>
    <dbReference type="GeneID" id="18260210"/>
    <dbReference type="KEGG" id="cthr:CTHT_0061720"/>
    <dbReference type="eggNOG" id="KOG0314">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019105_1_0_1"/>
    <dbReference type="OMA" id="NVPDHEP"/>
    <dbReference type="OrthoDB" id="106784at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16620">
        <property type="entry name" value="vRING-HC-C4C4_RBBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DWNN_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033489">
        <property type="entry name" value="RBBP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025829">
        <property type="entry name" value="Zn_knuckle_CX2CX3GHX4C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439:SF0">
        <property type="entry name" value="CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08783">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13696">
        <property type="entry name" value="zf-CCHC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01180">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51282">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DWNN" evidence="9">
        <location>
            <begin position="5"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="8">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="358"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="578"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="358"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="391"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="605"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS18157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="625" mass="68354" checksum="8E5FBC660BAA554D" modified="2011-10-19" version="1">MTSSVFFKFKSQKEPTRVEFDGTGISVFELKREIILRSGLGDGTDFDLVICADENMKEVYDDDTTIIPRSTTVIARRMPPKVPGKGNAARYVSGKMPIHAKNSSRREQIVKPTVKTQSSTLAQLSSAMTEEEKMAAVFQAQTENFTAREEEMATQQYVAKGGPKKPANVPDHDPPQGYICYRCGEKGHWIQLCPTNDNPEYDNRPRVKRTTGIPRSFLKTVDKATALGHNADGDESKVPSGIMVNADGEFVIAEPDKASWEQFQAKAKAKSDAKAAASEGDKEIRERGLECPVDKKMFIEPMKTPCCEKTYCNDCITNALIESDFVCPACKTEGVLIDDLKPDEEAVEKIKAFLAEKDSNKKKEDGSKSPRGDEKPESTDDSKKTEKAESVKATSKSPSPTPSTAASVTTNGQTTQASTNQQNKSSTSTASATNGEQQAATSSSSTSKKRPADELLENPKIPKAPKAMQQKEAQHQQQDMMNMMPSMGPMGFNPMMGPMGPMMYPGMPPMMPNFPMGPNPMGMGFPPMMNPMMFPNGGPANGMNGWGPGPNGMMNGWGGPNGMMNSGMGMGGPGMGFSGGPNQHKTFTHQPPPSEEEEAYFRKPVNPHRHMNRQRRIRPSDYREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFH9</accession>
    <name>G0SFH9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein arginine methyltransferase NDUFAF7</fullName>
            <ecNumber evidence="7">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0070890</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NDUFAF7 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="7"/>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697362.1">
        <property type="nucleotide sequence ID" value="XM_006697299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFH9"/>
    <dbReference type="STRING" id="759272.G0SFH9"/>
    <dbReference type="GeneID" id="18261127"/>
    <dbReference type="KEGG" id="cthr:CTHT_0070890"/>
    <dbReference type="eggNOG" id="KOG2901">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024840_0_0_1"/>
    <dbReference type="OMA" id="YYHPQRN"/>
    <dbReference type="OrthoDB" id="5595109at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12710:FF:000004">
        <property type="entry name" value="Protein arginine methyltransferase NDUFAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF7">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="338"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="344"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS17744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="575" mass="62516" checksum="0FC93747548D7271" modified="2011-10-19" version="1">MRTASRVLKSAHSARQLPASLTPRSSLRPFRSLSGLAHSSRPSIRPCTTPIALTLPRQLLSTTSPLRNESKPKEELKDEPKQEEIELEYEIDEDLSERKWSTPLAKTIAEAIEVTGPIPLASYMRMCLTADLGGYYTGALPASEANPERDPFGAAGDFVTSPEISQVFGELCGVWFVAEWMAQGRPATGVELMELGPGRGTLMDDMLRTMQRFPGIAKALERVYLVEASPQLRQAQKRLLCGDEAVLEGCEVGWKSRSKYGGVEIVWTESIRAVPMDPSKTPFIIAHEFFDALPIHAFQLVSVPASSDAKPSPIITSVSSPTPSPPQNPNLQWRELLVSPTPPGSTHASLNTPLSERSSPVPDFQLTLSPSPTKHSLYLPDSTPRYRRLKSLPPQQALNATIEICPDLFSHTTNIAHRIGGHPTLNPKPHPSGAALILDYGPGDGSIPTSTLRGIRRHRRVSPFSEPGLVDLSADVDFQAIVDTALDASEGVEVHGPVEQAFFLRAMGIAERAGEIVKKVEAMGDQKKKGDVERAWQRLVDRGPGGMGRVYKALAIVPEAGGRRRPVGFGGDVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFM0</accession>
    <name>G0SFM0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0071330</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAR2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697403.1">
        <property type="nucleotide sequence ID" value="XM_006697340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFM0"/>
    <dbReference type="STRING" id="759272.G0SFM0"/>
    <dbReference type="GeneID" id="18261171"/>
    <dbReference type="KEGG" id="cthr:CTHT_0071330"/>
    <dbReference type="eggNOG" id="KOG3937">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024943_1_0_1"/>
    <dbReference type="OMA" id="GAHFFWV"/>
    <dbReference type="OrthoDB" id="201752at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13778">
        <property type="entry name" value="Aar2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13777">
        <property type="entry name" value="Aar2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.550">
        <property type="entry name" value="Aar2, C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007946">
        <property type="entry name" value="AAR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033648">
        <property type="entry name" value="AAR2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038514">
        <property type="entry name" value="AAR2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033647">
        <property type="entry name" value="Aar2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038516">
        <property type="entry name" value="AAR2_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12689">
        <property type="entry name" value="A1 CISTRON SPLICING FACTOR AAR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12689:SF4">
        <property type="entry name" value="PROTEIN AAR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05282">
        <property type="entry name" value="AAR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20981">
        <property type="entry name" value="AAR2_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAR2 N-terminal" evidence="4">
        <location>
            <begin position="2"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="AAR2 C-terminal" evidence="3">
        <location>
            <begin position="217"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="421"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS17785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="471" mass="53313" checksum="C9B106A3B4D20B25" modified="2011-10-19" version="1">MHLPNDLIIGLDTIAMTTSKSLTGFRDIPPGAHFLWLQQPNGISRCGYWFITERHGTVRVKKWNRFHEVLAEPTAQEVRNIEASIETTYFSLQPYNIYEQQKQQKSPNTETIFNPSLVPQWARTQTLLWHTLTWAISTPFLECITGKKGVKEYLVDSTDCAKEIIKDSSHQEPIFSASKPLFNSTSSEFSFSFTQDFRDLQFLDAAGLADTKASVSDTTPRILAALNNGKSTTRDILAELQFTFITGTQLSNSACLDQWWSLVLKILLRAHALAVSHPMLARDLILTLHAQLYFTENYVGEASQARDSQDGKNKDVGATEPGSGRRNGPNADRLLYQYRPVNRLRLRHALAEYKRRLRTHGVILESNSDSGISATIIQQQEEERAALAHAWEELESWLWRCGWDLGRVEGERDAGRKEMEEFGRGNGFDGSKGKVMRQWPGDSEDEDEDGMPVVVELDENGREVGLVSFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFS0</accession>
    <name>G0SFS0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dioxygenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0071900</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697453.1">
        <property type="nucleotide sequence ID" value="XM_006697390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFS0"/>
    <dbReference type="GeneID" id="18261228"/>
    <dbReference type="KEGG" id="cthr:CTHT_0071900"/>
    <dbReference type="eggNOG" id="ENOG502QT05">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036005_0_0_1"/>
    <dbReference type="OMA" id="TEFANSY"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000003">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF28">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT TAURINE DIOXYGENASE (AFU_ORTHOLOGUE AFUA_8G02210)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="77"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS17835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="368" mass="41958" checksum="BF603CE7A564509A" modified="2011-10-19" version="1">MATTTITKTNTEELPLRLTVAYDEKLHEKYKYTEYLPVYDEVTKFPPLKPFEFNDRGLVANKDKPNLFSKDNPNLKVTKLTPLIGTEIRGLQLSQLNDLQKDELALLIAERGVVVFREQDFKDIGIEKQKEFGRYFGPLHIHPVGAHVKDHLELHNIYLGPDNEYRSKRRSNRLTSTGYHSDVSYERQPPGITILTLLSVPPTGGDTAWVSQTAAYQRLSSPIRALLEGLRAEHSGFPQAEQARRDGKFVRREPVATLHPIVRVHPATGQKALFVNPGFTKRIEGLKDEESDALLRLLFDHITKGQDFQVRVKWEEGTVVLWDNRVTAHTAISDYDVHNPQEGLRHGFRITTLAERPRGVNGLESIWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G0SG11</accession>
    <name>G0SG11_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0064640</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696768.1">
        <property type="nucleotide sequence ID" value="XM_006696705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SG11"/>
    <dbReference type="GeneID" id="18260502"/>
    <dbReference type="KEGG" id="cthr:CTHT_0064640"/>
    <dbReference type="HOGENOM" id="CLU_1170534_0_0_1"/>
    <dbReference type="OrthoDB" id="3594103at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="26326" checksum="95AEFA5F327F8013" modified="2011-10-19" version="1">MLKEELQAVKQWDHKIDLPSTSYQAGHALVNYLYCGSLDCHGHGSNNGPPPQQKLALLLEIYALARTYVLPGLEVLAREELESLAAKFSPFELFDAAKISYPTSVGDDVWFPGFVKVCIKAALQNPSSLQVERNLTDYTNGGSLVKLFLSFANDEAASEASDDAMMQPTPSEVTSTTERSPTSTSQLMVTQQHEAKDDSSPTPVYRDLVNLLERLKKCSTETDPYDKDYLKGNWRWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0SG88</accession>
    <name>G0SG88_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ste24 endopeptidase</fullName>
            <ecNumber evidence="3">3.4.24.84</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Prenyl protein-specific endoprotease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CTHT_0065460</name>
    </gene>
    <organism evidence="24">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic side chains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.24.84"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="19">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the peptidase M48A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.84" evidence="3"/>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696845.1">
        <property type="nucleotide sequence ID" value="XM_006696782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SG88"/>
    <dbReference type="STRING" id="759272.G0SG88"/>
    <dbReference type="GeneID" id="18260584"/>
    <dbReference type="KEGG" id="cthr:CTHT_0065460"/>
    <dbReference type="eggNOG" id="KOG2719">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025947_3_1_1"/>
    <dbReference type="OMA" id="FYPFLWG"/>
    <dbReference type="OrthoDB" id="360839at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07343">
        <property type="entry name" value="M48A_Zmpste24p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.10:FF:000002">
        <property type="entry name" value="CAAX prenyl protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027057">
        <property type="entry name" value="CAXX_Prtase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032456">
        <property type="entry name" value="Peptidase_M48_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000271">
        <property type="entry name" value="Ribosomal_bL34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10120">
        <property type="entry name" value="CAAX PRENYL PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16491">
        <property type="entry name" value="Peptidase_M48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00468">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="10 23" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9 19" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 1 N-terminal" evidence="22">
        <location>
            <begin position="41"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="21">
        <location>
            <begin position="228"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="active site" evidence="18">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="18">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00060927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF16491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EGS17227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="682" mass="77418" checksum="511543AB435FA11B" modified="2011-10-19" version="1">MLGFLQRLARFLDRPLFPWKKLIIGFSVGQYLFESFLSWRQYQVLQRTQPPKVLEHEVSQDVFDKSQAYSRAKAKFSAINGLYSQLLNLGFYHFDVLPKLWSWTGDLLLRWAPARFSGEISHSIVFILAFIVIQQVLSLPSSIYQTFVLEEKFGFNKQTPKLFVTDLIKTNMLFFFLVPPILFGFLSIIKKTGNQFFYYLWMFGAGLQMFMITIYPIVILPLFNKLSPLEEGKLKTDVEDLAKKLKFPLHELYVIDGSKRSAHSNAYFFGLPWKKHIVIYDTLIEKSENDEVVAVLAHELGHWKLGHTTKIFGISQAHFFYIFALFSVFINNNSLYADFGFTDQHPIIIGFLLFSDILGPMDNVIKLMMNILSRKFEFQADGFAKELGYKTELARSLIKLQIQNLSTMDADWMYASYHFSHPILPERLKALEWVPTSKVAVEKPQSEKDTKEDVAVATGRDELCRRSVQQSRLRNPNRNGQFELDQKLWDYDGVSGNSTANPLAKAATNPIVRNDSMVSVTKVQVTPATMSRVTTTALQAALRRPTARLLASRVSAMAIVSKPTARSFSHLPTLRPTLVPSSPVFRSPTSTSTSTTSMFQPTSALNGSLAAAADVVPKSSLLGSHPSMDAAQIRAGPRNTMNRSTRLIQKRRHGFLARKRSKTGQKILKRRICKGRKRLAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGF6</accession>
    <name>G0SGF6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ubiquitin conjugating enzyme-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0066150</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696913.1">
        <property type="nucleotide sequence ID" value="XM_006696850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGF6"/>
    <dbReference type="STRING" id="759272.G0SGF6"/>
    <dbReference type="GeneID" id="18260653"/>
    <dbReference type="KEGG" id="cthr:CTHT_0066150"/>
    <dbReference type="eggNOG" id="KOG0428">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041481_0_3_1"/>
    <dbReference type="OMA" id="YHGRITF"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000093">
        <property type="entry name" value="Ubiquitin conjugating enzyme (UbcF), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="4">
        <location>
            <begin position="14"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="240"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS17295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="319" mass="35233" checksum="A1D74298C157F98A" modified="2011-10-19" version="1">MATTAPRQFNSKSPTIRRILREAHELATSPSPDYHASPLETDLFEWHFTLRGPPNSPFEEGIYHGRISLPPTYPYRPPSFRFLTPSGRFETNREICLSISGHHEETWQPAWGVRTALVALRSFMETDAKGQLGGLEAGEEVRRRLAKESRTWRCGVCGGGKTNGEILEEWEEKVRELEKEGKGAVKEEKVPEELRLAWRDELVGGKKGGDKDGESDGESARLAEGFVQTAPAEKETTAIAAQPATGGPPRAQTTSSSTAPVTTQPETRPLPVQTQPQPQQQLAMQQPRADEDNVTLWLDRLIVAVAVLLVAVILKVLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGK8</accession>
    <name>G0SGK8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP-3 complex subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0066690</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Adaptor protein complex 3 (AP-3) is a heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696965.1">
        <property type="nucleotide sequence ID" value="XM_006696902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGK8"/>
    <dbReference type="STRING" id="759272.G0SGK8"/>
    <dbReference type="GeneID" id="18260707"/>
    <dbReference type="KEGG" id="cthr:CTHT_0066690"/>
    <dbReference type="eggNOG" id="KOG1059">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001908_3_0_1"/>
    <dbReference type="OMA" id="SGNNWMA"/>
    <dbReference type="OrthoDB" id="10264595at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017105">
        <property type="entry name" value="AP3_complex_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781:SF12">
        <property type="entry name" value="AP-3 COMPLEX SUBUNIT DELTA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781">
        <property type="entry name" value="DELTA ADAPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037092">
        <property type="entry name" value="AP3_complex_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="10">
        <location>
            <begin position="39"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="348"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="737"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="911"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="857"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="352"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="780"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="809"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="927"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="962"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="987"/>
            <end position="997"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS17347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1011" mass="110887" checksum="E4782FECE596A399" modified="2011-10-19" version="1">MYGCSPLPTCAQPADAGCPRFEKSLYDLIRGLRNHKGSEKEYIQSCLKECRSEIRSQDMDVKATALLKLCYLEMLGHDMSWASFHVLEVMASQRYHQKRVGYLAAVQSFRSDTDVLMMATNLLKKDLAASLPIIMSLPIGALPHIVTPSLSMSLLGDLLPRLTHSHSAIRKKTVVTLYRLALVYPEALRAAWPKIKERLMDPDEDPSVTAAIVNVFATLTPLEPRLVRKLLPPLTNLIRTTPAMSLLYECINGIIQGGILGDASDFSAREEIASLLKYVALLAFNKIVATHPFLVAEQEDVILECIDSEDITIRIKALDLVQGMVSSDNLISIVGRLMRQLKAASPSAELNSLDDSEQDSSDEANVDPKRRSKPQEPLIPLPEDYTIDVIGRILKMCSQNNYANIVDFDWYIDVLTQLVRIAPTPPPQEVESDSATSISKLAAEISERIGNELRNVAVKVKAVRPAAVRAAELIISRLTIETSITRPALNGALKPVAWVVGEYASLLASADDALRNLQDLLPRIRDPEILATCLQAVLKLFAYVAGNDQIPWTPERKSMVSLLMARVIHVIEKFVSHPYLEVQERAVEFVELLKLTAEAAAGQTPSTAELHQDPPLLLTQAIPSLFAGWELNSVAQGAQYNVPIPDGLDLDEPIHPDLPRLLAQADSLSLPDQSEDEFAAYYHQKPPITSISSTEPAINKLGEAPEYTGSYQQHAAEESYLDPDTIARRKAERMERYRDDPFYIPPEPIRSSTPIHNILQKENGPDLDIDSIPIMQLDLGPTGTPSSTPKPIAAKPKPRQRIVVAADETLSTSLPNRASGTSTPRSYDSDPTLSRPSTAATRKAKQQSLLQVDSSHLESLSLDASESAAALERQQREEAEMQQALREVQRLRLEMQRANERIMVAQAKGVTAEGVVVASKPKKKKKDDKEKRVKVGESEGVEGKVKKKKKKKAVESQKAEGSGTGSGTGSGTGTGEGASEPAAVGVVKKKRSGKAKRLVQLDDREEAGGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGP5</accession>
    <name>G0SGP5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0067090</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697002.1">
        <property type="nucleotide sequence ID" value="XM_006696939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGP5"/>
    <dbReference type="GeneID" id="18260747"/>
    <dbReference type="KEGG" id="cthr:CTHT_0067090"/>
    <dbReference type="eggNOG" id="ENOG502RF9B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045142_0_0_1"/>
    <dbReference type="OMA" id="KCQEMMQ"/>
    <dbReference type="OrthoDB" id="5234702at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="447" mass="49131" checksum="12B32E2ECE5EDBA9" modified="2011-10-19" version="1">MATSIPLPFQAQIPVTPPPDFQMFMKGPTPPPPHTTTPFPNPFSPLAAHHPNHVAAAAAAAAYFHHPPHQEKSTFSSPHPSPLQPQTTQKQTTPQQRQPSPHPGPQPSPTACPCAAAAAAASSQNPQAASCSTSKPPPPSPLGPDPASNTTMDPSAAAAAAAAAATAVDPRYIAMASRIASYYQQRCQAVANFQQQRCQAWANAQRQKCQEMMQAATVIVAWYIRDRIQRKRRKQRKAFKRGLAQRAREAIRERESGRGMSKGERVRRWVMSVPTGEENASQAGSAAARRSPELPADQEEREFDIDRERGEDKDSQLYNVADNLIKSHLARIDVPLLGVLSFDPESESSDSEESDYELMDYEDEPELGEEDPGEEEEEEDDDDEEEEYDDEDDAEDDDGYNDYDDYYEDQRRGRGAGRDGKADETASKAAQIGTTKGSRKRSRSSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G0SH16</accession>
    <name>G0SH16_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0068340</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697123.1">
        <property type="nucleotide sequence ID" value="XM_006697060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SH16"/>
    <dbReference type="STRING" id="759272.G0SH16"/>
    <dbReference type="GeneID" id="18260872"/>
    <dbReference type="KEGG" id="cthr:CTHT_0068340"/>
    <dbReference type="eggNOG" id="KOG0586">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019271_1_0_1"/>
    <dbReference type="OMA" id="IARCEWA"/>
    <dbReference type="OrthoDB" id="410920at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000640">
        <property type="entry name" value="Serine/threonine-protein kinase PRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF42">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SIK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="362"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="13"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="171"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="228"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS17505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="716" mass="77887" checksum="16E1C71CC6C7B29A" modified="2011-10-19" version="1">MASLPLQPLQIPPLTSDDACGSSSSSVNSITDCDSHSEQHDQERIALDVPPASAPVALSIDATQSTHLDSVHAAASSRFYPLLPVAVKSLDMHCSYGNTTSHNTFVHSNGVRRPALTLHAKSSTQSLRPVSRTPSLKARSICNPFGSTSATSSTVPSPVISAMGEVTPLPSPLLGSDSPTPWKHLMGRKASRDTSFACPTPSPDVDGAPSATPSRSASIKKPYAGLTTWPTLDNTPEESQPATPVKPASGHTRNRSISDYRPDSVLIPKRTPTVSGTRPKDINPKSVAGDGHLRREPHLAGARGLTSIEKPPTPPPSESSLSIADSGYMTSSGSSNPPCISKSADVEYFEAYDRYDSKLRRWRAIRVLGQGTFSQVVLATSQTTATAPDEDGTGAHADVSSPSKHDRRSLVAVKICEHGPRGGASEQRIEMSLKRELEIMKDIRHPSLVHLKAWNIDQSRAILVLSYYPGGDLFDLASNHRDILTQSLLRRMFSELVGAVRYLHDRNIVHRDIKLENVLVNLPAKELADSDMDWTTYPYPVVTLTDLGLSRRVAPDEKLETRCGSDDYAAPEVIMGQPYDGRATDAWSLGVLLYALMESRLPFDPPPNLVGDYAVHMRMRSRTSHRIARVEWRWYLYGVDDGHQDDADGDHDADPAKFAAAGLQGACEAVEGLLKRARNRWPLAKIAEIEWVKGGINVPGGIRFREEEEGEEVLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0SH66</accession>
    <name>G0SH66_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin-like fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0068890</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAX family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697173.1">
        <property type="nucleotide sequence ID" value="XM_006697110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SH66"/>
    <dbReference type="STRING" id="759272.G0SH66"/>
    <dbReference type="GeneID" id="18260927"/>
    <dbReference type="KEGG" id="cthr:CTHT_0068890"/>
    <dbReference type="eggNOG" id="KOG4244">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044137_1_2_1"/>
    <dbReference type="OMA" id="MEYAERI"/>
    <dbReference type="OrthoDB" id="5809458at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026928">
        <property type="entry name" value="FAX/IsoI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF41">
        <property type="entry name" value="FAILED AXON CONNECTIONS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17172">
        <property type="entry name" value="GST_N_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01180">
        <property type="entry name" value="SUF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01200">
        <property type="entry name" value="SUF1.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like fold" evidence="3">
        <location>
            <begin position="34"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS17555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="271" mass="30884" checksum="B8D25A2FD820DFD5" modified="2011-10-19" version="1">MEGKEVSDTTVAQIKPEIILFRGFTWTLRHVWSPFVVKLEARLRFAGVPYKAAAGTPREAPRGKVPYIQLGNNPALIGDSTIIIRTLIDQGIMPDLNKELSGEDKARDLAIRALLEDKLYFFLVRERWEDNYYKMRDGVLEPLPYPVRMVVGYLVHRRTMEMLYGQGVLRYTKVEAAALRREIWEAIAEMLKESQSKLVLQGACHDILKPFWILGGQNPTEADAVVFGFIVSSLVCEAGPETANMIRSFPVLLQYATAIHDTYFNEYQGWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHD8</accession>
    <name>G0SHD8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="21">WD40 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CTHT_0069670</name>
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    <organism evidence="22">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="22">DSM 1495 / CBS 144.50 / IMI 039719</strain>
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        </source>
    </evidence>
    <sequence length="2313" mass="259063" checksum="C6E1C0B9C5A0B18E" modified="2011-10-19" version="1">MGRSDSDSEDYEVEQPSLPDDDPMRAYIPATFGKTTREANIEAQIERTRRKVEPKKPEQKKPLMVTSKMDSEDESESDSDSDSDDSESEDEAEKFPVTHEIVLKTHERAITTIALDPAGSRMLTGSLDGTIRFHDFTSMTPTTLRAFKSIDPWETKKSVNNDSHPIQHLEFSRHSGGLFMCVTAHPQLKIMDRDGAVVTEFVKGDMYLRDMHNTKGHVGEINNGTWHPLDQNICITAGSDSTVRIWDINNKRCQKEIIVFKSKAAGAAGRTRMTAVAWGSPPEGNSSLIVAAALDGSLVMYPGNGPFTRPAGEVKDAHQPDTWTGGIDISPDGRMVVTRGGDGLIKLWDTRKFKAPLIKVEHASTSDRYPMTNIKYAPDARYIITGSVNGELHILNPANLRPEHVTPITPGVPLITVEWHPKINQIITGSANAETHVLYNPKLSHRGALEVMSRAPKKRHIDDDPAFTMDQSSLGFSGDAIVAPGALGRRGGVSASGKSRDPRRPQVQQITPFMRSQPDEKHIEQNIPLSKMLHEDPREALLKYAEVAKKEPLFTNAWAKTQPVTQYAELSDDEEEGPEKKKVKRRAAAAMMGQPTNCILRLAGTAEPLPSACMNAASGVSPHQQEGADRPRDRVSARIKKITNLPPRRINAISKQPASDGAINSQPHPPATTLETPLCLHDFLYFDHAKTRTLLFFSPPGLCSPFFAPRRAQAGHLQPLSLPPPPPLLRLFHRRDNHTPADPVARAHHHNVFAGRRSDRPYRAIAINRTDAVVDSAVAMTSVQVPQVPPAVQLPGTAIPANMTQQQAQEVYKRWRQMKESGVPPTDPEFIKTQNILSALQRQSDMRKQMQMQQQMQLQQQQQQQQQQQQQQQQQQQQQQQVMQNGANGVINGTQFGRVAQPGAAPASMPPATGALGASALPAGSAAPAQNAAGASALPPQLQGHPHFTQAQLNLLMNQIKAFRMLGKNAGVPIQMQKAIFEHRARRRQSLGKQEPQPAATSVTPTTSAETPAPDASKPAVNGPEAIKAAAPATTTASLSDPQSKTFKTVKSPFDAGFVRKTISYIDHSRRKNRQLVPGLFPTGIDFEQLRADREKIIFNRMSQRYQELKSLPGNLAHWDASKDELVADDTAKRKAIIEMKKLALYSKQRALREKIGRQMMHYDNLAMTTNRAQYRRMKKHNVREARITEKLEKQQRDARENRERKKHIDFLQAIQNHRNEVLNAGAAQRLKMSKLSRHMYNHHFNIEKEEQKRIERTAKQRLQALKANDEEAYLKLLDQAKDTRITHLLKQTDGFLKQLAASVREQQRQAAEKYGEPMDIPSSEDEDEDDENGRSKIDYYAVAHRIKEEVTEQASILVGGTLKEYQLKGLQWMLSLYNNNLNGILADEMGLGKTIQTISLITYLIEKKKQNGPYLVIVPLSTLTNWNLEFEKWAPSVTKVVYKGPPNARKMQQEKIRQGKFQVLLTTYEYIIKDRPLLSKIKWFHMIIDEGHRMKNTNSKLSATIQQYYTTRFRLILTGTPLQNNLAELWAMLNFVLPNIFKSAKTFDEWFNTPFANTGGQDKMELTEEEQILVIRRLHKVLRPFLLRRLKKDVEKDLPDKTEKVIKCKFSALQARLYKQMVTHQKIIVSDGKGGKTGARGLSNMIMQLRKLCNHPFVFDEVENQMNPQNISNDLLWRTAGKFELLDRILPKYKATGHRVLMFFQMTAIMDIMEDYLRYRGLHYLRLDGTTKSEDRSELLKLFNAPDSPYFMFLLSTRAGGLGLNLQTADTVIIYDSDWNPHQDLQAQDRAHRIGQKNEVRILRLITSNSVEEKILERARFKLDMDGKVIQAGRFDNKSSETDRDAMLRTLLETADLAESGEQEEMDDEELNMVLARNEEELAIFQKIDEERNRDPIYGTAPGCKGVPRLMTEDELPEIYLHEGNPAEEENEVHLGRGARERKQIRYDDGLTEEQWLMAVDDDEDTPEAAAARKQARREKREQNKLKRLAMLNASMENSPSASRASTEDVETPKKRGRKPGSKNQEKRKAEDGDDEPPAKKRRGPQGRPKAVGTSSGGSALAPELRDKLQKACRRIFDGLMNLAVDDDEPPEKPEGENDDESEDEGPPKRLIIGPFVKLPPKREWQDYYVIIQNPICMNDIQKKIKREEYNSLGDMRKDLDLLVTNCRTFNEETSGICQDANTIEAYFKEHFAKELAEDPDLRALEDPNSPNLVGLNVDGVNSSASSSSAEASGPATTGESSAAQSSQPASSTTSTTPAPAPAPAAPTGPPRIKLVSSANKENKGDTNASANGSAAQTNGGVNGVANGNSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHG7</accession>
    <name>G0SHG7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cell division control protein 42-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0069960</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697274.1">
        <property type="nucleotide sequence ID" value="XM_006697211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHG7"/>
    <dbReference type="STRING" id="759272.G0SHG7"/>
    <dbReference type="GeneID" id="18261034"/>
    <dbReference type="KEGG" id="cthr:CTHT_0069960"/>
    <dbReference type="eggNOG" id="KOG0393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_841979_0_0_1"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01874">
        <property type="entry name" value="Cdc42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000236">
        <property type="entry name" value="Cell division control protein 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037874">
        <property type="entry name" value="Cdc42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 13" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS17656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="330" mass="36402" checksum="04D6DB4A7732291A" modified="2011-10-19" version="1">MDLTGHTYLGSRSARTGHTPGCPPAPTSPAQDLLGPTSLPGFPKPPPSDLQRSVLLANKGELAVALTPAFSHAGRLIPFVTLIIHRLLRLESHLREWRSERSSASTSSSILLPPFLLLLPSLRPLRIASELAVDRLDVSWTRCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGDEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVTSPASFENVREKWFPEVRHHCPGVPCLIVGTQVDLRDDPQVLNRLAKQKMQPITKEQGEEMARRLGAVKYVECSALTQYKLKDVFDEAIVAALEPPALSKGKKHRCTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHU2</accession>
    <name>G0SHU2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Polysaccharide synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0073370</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697594.1">
        <property type="nucleotide sequence ID" value="XM_006697531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHU2"/>
    <dbReference type="STRING" id="759272.G0SHU2"/>
    <dbReference type="GeneID" id="18261375"/>
    <dbReference type="KEGG" id="cthr:CTHT_0073370"/>
    <dbReference type="eggNOG" id="ENOG502QTJK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019940_4_1_1"/>
    <dbReference type="OMA" id="HEKHIWY"/>
    <dbReference type="OrthoDB" id="3828420at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06434">
        <property type="entry name" value="GT2_HAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052427">
        <property type="entry name" value="Glycosyltrans_GT2/GT47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844:SF1">
        <property type="entry name" value="EXOSTOSIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844">
        <property type="entry name" value="SYNTHASE CPS1, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G02500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13641">
        <property type="entry name" value="Glyco_tranf_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="427"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="428"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS17012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="506" mass="59088" checksum="253D5068272F05BA" modified="2011-10-19" version="1">MPGLMDIVIPRWDLDFLWSPKFWAIFHTILWLHRYVRLLVHCVSHWCYKSVQPKWTNPKYKSSDVTVIIPTIHNRPEELRPSLESILACQPAKLILVTTYNKYEALGRVASTLRVPKCDPPIEIEVLHVDKANKRLQVCKALEDDHVRTPITVMADDDVEWPSTLMPWLLAPFEDDRIGGVGTCQRVKRIHEGDIRTRIWNWLGAAYIERRNFEISATHNIDGGTSCMSGRTGAYRTEILKSYDFLDNFKNERWGRYILNADDDNFVTRWLVAHQWKTWIQYEPECEIETTLENSYKFLYQCSRWARSNWRSNWTSLFVERHVWRQQPWCTYALHIATFTSLAFVVDPLLLFTCWWGTEGWNMRDRYILLGAEIAFMFGFTKVVKLVGLFRKNPKDIMFLPVSILFGYFHGLIKLYALFTLKETSWGSREDGDEHNTFRLQEKPPRSQAMTTPSGPDLPKAMRHARLTQIRRVVVASQKAEVDSSSPIKGKAEGLYSIENMKSMLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHZ1</accession>
    <name>G0SHZ1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0073890</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697643.1">
        <property type="nucleotide sequence ID" value="XM_006697580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHZ1"/>
    <dbReference type="STRING" id="759272.G0SHZ1"/>
    <dbReference type="GeneID" id="18261427"/>
    <dbReference type="KEGG" id="cthr:CTHT_0073890"/>
    <dbReference type="eggNOG" id="KOG1199">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_42_0_1"/>
    <dbReference type="OMA" id="RHIFEND"/>
    <dbReference type="OrthoDB" id="3819888at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658:SF8">
        <property type="entry name" value="17-BETA-HYDROXYSTEROID DEHYDROGENASE 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS17061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="324" mass="34261" checksum="6F6704BB45B4E4BA" modified="2011-10-19" version="1">MKIEGRTFVVSGGASGLGLATIQSLLSAGASVALLDLPSSQGPSLAQSLPRTIFIPVDVTSTSDITAAVEKVKSWIAETGHPLGGIIPCAGVGLPGLILDKKLNPVSLESIDFVLNINLRGTLDLVRQFLPLLAKAPPEGKDGERGVVVMVASAAAFEGQMGQVAYAASKGAVASMTLPMARDLSRFGIRVVTIAPSMFDSAMTAMLSDKVKEGLRKAMEFPARPGQPEEFASLVKHAVENIMLNGVVIRLDGATRMPSEVYVSVNATPSSRMMGFCADNVQPIDQDAIYPCNAKQRHLVADLSSRFPILIPHSNQVTHNYDPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0SI20</accession>
    <name>G0SI20_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Structure-specific endonuclease subunit SLX4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SLX4</name>
        <name evidence="11" type="ORF">CTHT_0074190</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a heterodimer with SLX1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="9">Phosphorylated in response to DNA damage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SLX4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697672.1">
        <property type="nucleotide sequence ID" value="XM_006697609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SI20"/>
    <dbReference type="STRING" id="759272.G0SI20"/>
    <dbReference type="GeneID" id="18261457"/>
    <dbReference type="KEGG" id="cthr:CTHT_0074190"/>
    <dbReference type="eggNOG" id="ENOG502SEB3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005957_0_0_1"/>
    <dbReference type="OMA" id="SICCLWK"/>
    <dbReference type="OrthoDB" id="5349119at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22999">
        <property type="entry name" value="SAP_SLX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03110">
        <property type="entry name" value="Endonuc_su_Slx4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027784">
        <property type="entry name" value="Slx4_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018574">
        <property type="entry name" value="Structure-sp_endonuc_su_Slx4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02178">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09494">
        <property type="entry name" value="Slx4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="101"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="243"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="285"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="644"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="868"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1082"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="683"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="722"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="735"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="766"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="868"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="896"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="948"/>
            <end position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS17090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1121" mass="120112" checksum="78AF21B7697E683F" modified="2011-10-19" version="1">MIADQSPIVISSSPDFPLLPDLPLKSNPRPFLRDGGHAASIPDDAPQTLTSAAKTWQSSGSGISDESMPIGRGKAPITQTAQNAIILDSEDDQPQTAFSLDSLKADSQPASRKVDVNSMSDASRAMAQEKLSNGMVTKPSAKDSQSRKQTETVSRHFAPAPQELALARRLDWTPPRDLNSVLPPLDSSTTKEVFSPEEDGRPSPKEVFRNLQDTFGLKEDDLPRTDLDAAPARTEVLGKRKLIEMGSVSSMQPSPEASPTKPRIKKKQRTLTELATAAYRVSEDSDVAMGENGPKQGSMLSYLNADKGASTEEAKTVPKKPTKRAIKPRGNASRKKQEPPKPVLLSPQSALKEVSRQDFVFGTASQLALEDDPELLRAVHEAMKISNQTDSDPFTGSSPVTKSNLAIRKRPGTGLWAAGARDENGDLVDLEEIDLTASSPSLDRLLCSKSQENNAARSFAVNDRIELLSDDSSEFPDVSSVIGSISAAAPVKDLSQPASPNGVSKIVIDSDNFPDVSELVGGAATSTPPSSQKPAAVAPLIQIDDSEDGEHVSPEFEPPPSNQEQLMLLSQSRNSAPSQSQMPPRPNFELYTDARLAKEVSSYGFKAIKKREAMIALLNQCWESKHKVGLGSRLSQVSMSITSANLARKKQSSAASSDDETPPEPPKKRGRPRKSSTSTTSEAAKETKTTKKKTTKTESKTRKEAEGEEEPEPEKKGRGRPKKTETAEPAESKAAKASTTKATKKSAATKTKAATTATKTTKKSSKAQASKPAPEKSTAASTEPQPEAPPEVEPIVEIVDSELGNALLRSPTVILSTAYKPAVRREAEKLVAPDDLLPPVLSATVSSKDWPLLTGTAASITAVPTAAATTSSKSKTTTTKSIAKSTTSLLRRKSPTRTATATAAETTKTKTTSSGARSKSPTHTTTATTPRRRKSPMSVIEIADSESEGSLSSPKSEIFSSLPPEGMDLSVTEETDDTSLVTSPTTRQLDMFKYITEAVTSAPPSTDVENPSWHEKMLMFDPIIIEELTAWLNSGQLARVGYVGEVAPEDVKKWCETYVPFFSNVVFSVIASNGSVVKNGAAGPISPDLRLQDSGADKRGTLRQKRPQQVLSRVPRLTPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G0RY16</accession>
    <name>G0RY16_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0005060</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006690981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RY16"/>
    <dbReference type="STRING" id="759272.G0RY16"/>
    <dbReference type="GeneID" id="18254544"/>
    <dbReference type="KEGG" id="cthr:CTHT_0005060"/>
    <dbReference type="eggNOG" id="ENOG502SATJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056572_0_0_1"/>
    <dbReference type="OMA" id="RREANDH"/>
    <dbReference type="OrthoDB" id="4158841at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17242">
        <property type="entry name" value="DUF5315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="351" mass="35789" checksum="AF0B7BC3B6A7E87C" modified="2011-10-19" version="1">MSQKELTKGTASTRSPFPSLFQPPSQSTTPHGSQPGPPSGGTSGFTSTLNPPTAFSGTNNSLRPGTSGTASTTLQNPFTAGLGTGPSLTVPPTGIAAGQPTTHPRSSSISLSIPRPPSRDSRASSSRRGPASDRVDALWAEMQATLEAVELSAGAAIGGSDSQGGATGGVRGRRIFSPEHERMLDELRKAQIALAQAWARSEADEAIETGNAEGAGAGGDGGGATSEAAAAVTATGAGAKSVDGAGDGTKSTAGTMSAAAARPGSSGFVAGAEQQGKEEEVETEVDILLARKRREANDRYFQRVNQGVLDVVAKLDQVAISMRAVEQESKQLWGDEQQEQDQESVPDSSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0RY64</accession>
    <name>G0RY64_CHATD</name>
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            <fullName evidence="2">Putative vps protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">CTHT_0005580</name>
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        <lineage>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23850.1"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="759272.G0RY64"/>
    <dbReference type="GeneID" id="18254596"/>
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    <dbReference type="eggNOG" id="KOG3229">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069208_0_2_1"/>
    <dbReference type="OMA" id="KILWEVT"/>
    <dbReference type="OrthoDB" id="2329734at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="241" mass="27164" checksum="A82261BF045C5C68" modified="2011-10-19" version="1">METLRNLFGKPDPQAQFRKCNAMLRAEMRKLDREIANLKNVEIKTKNMILAADRRARRAASGPNANSRAKQQAEREVRDFARELVRTRKTTQRMITSRAQLASVQMQVNEAFALRKIQGSIRASVGIMKDVNALIRLPELAVTMRDLSVELMKAGIIEEMAEEMLPTADVELEMEDEEAEGEVDKVLGEILKDRMEKTGPLPSVPTGTTESVPAQQALEEEDADTQAMLDQMRNRLEALRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0RY69</accession>
    <name>G0RY69_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0005630</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type III membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OST4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691097.1">
        <property type="nucleotide sequence ID" value="XM_006691034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RY69"/>
    <dbReference type="GeneID" id="18254601"/>
    <dbReference type="KEGG" id="cthr:CTHT_0005630"/>
    <dbReference type="eggNOG" id="ENOG502SZVF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2037800_0_0_1"/>
    <dbReference type="OrthoDB" id="2124077at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018943">
        <property type="entry name" value="Oligosaccaryltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051307">
        <property type="entry name" value="OST4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036330">
        <property type="entry name" value="Ost4p_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48164">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48164:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10215">
        <property type="entry name" value="Ost4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103464">
        <property type="entry name" value="Oligosaccharyltransferase subunit ost4p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="91"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS23855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="121" mass="13159" checksum="70211CA10B7F4A26" modified="2011-10-19" version="1">MCTQVVIITNINHISLVSSVCCATTRKPQASFDPSEPTAYQTVSLSATTNKLEMITDGELYRLAIFLGSAAMILIILYHFFEINANEDEGKAVQEKAADKAPMEKTSKSPTLSAATSTKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYE4</accession>
    <name>G0RYE4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0006400</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691172.1">
        <property type="nucleotide sequence ID" value="XM_006691109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYE4"/>
    <dbReference type="GeneID" id="18254678"/>
    <dbReference type="KEGG" id="cthr:CTHT_0006400"/>
    <dbReference type="eggNOG" id="ENOG502QW4G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035426_1_0_1"/>
    <dbReference type="OMA" id="YYDNQQW"/>
    <dbReference type="OrthoDB" id="5401193at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="424" mass="44375" checksum="ECDA9005449EA506" modified="2011-10-19" version="1">MSAYYEPSQWPPTGQPGWDHQTPPPARSGANSAIPREEPQAFAHQLEEVDRAIDNLVKSGKMFAYPGARRESLPPYPGPARFYPAFDARPPAIPGARPHPIPEFDPRAPHPAANLQNFYAAQRHQPSRGSNEAEQMMQAKRRMAAQRERELRNYHQEQQYNRTVLAGMPYGPDKPDRTMSPGGMSEEERRKLIAQQRSALYGEGPFGESGGYVDESGAPRPGLPGPQAGPAGLRGHSPLAYDYGRAPPVHPDAAAQASSAEGGQGAQSAGPNERSRANSNSSPQSNPPAGGKGMFDSPAAVQQSSRTSASSPGGSPPRQSAPGAPGSGKPSQTTVAPIGTRPSVTSAPTNPALNKRSTTPLPSPLSQGYTASSGNEEGANTGNNNANSSSAGTETPNVGLAGWGARSNGWGSKSGLGTQASVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYG0</accession>
    <name>G0RYG0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0006560</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691188.1">
        <property type="nucleotide sequence ID" value="XM_006691125.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0RYG0"/>
    <dbReference type="GeneID" id="18254694"/>
    <dbReference type="KEGG" id="cthr:CTHT_0006560"/>
    <dbReference type="eggNOG" id="KOG3417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001471_0_0_1"/>
    <dbReference type="OMA" id="ICNYATM"/>
    <dbReference type="OrthoDB" id="10254377at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF363">
        <property type="entry name" value="PROTEIN SON OF SEVENLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="420"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="1556"/>
            <end position="1820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="232"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="562"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="841"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="991"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1073"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1239"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1326"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1376"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1443"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1496"/>
            <end position="1520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="841"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="855"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1257"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1392"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1448"/>
            <end position="1461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS23946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1822" mass="201568" checksum="2E9153BA478A9463" modified="2011-10-19" version="1">METGLSSPHSPPRPSPTTGPLQQQQLQHPLSPRHAQSQDPASSLSQPPPPPPQQQQQQQQHHHHHQRRAFPDALRLRVPPRPGKDGAGGRSRTGRAGGAGISLSKSKLWGSSSGAAAHAKPLLPVTERKSHDENLRGATGRRLKKGSLDSDKWDITPDGSSAGREGRQFTVANVGNNGRIYLRPTIRPAHQRIPQPHFVFPMTPPDTAGLGGSFTTELRRDSTAQLTDVDDQWHLPSTEPNPGRATPSYRRHRRAMSDSTIHETNPEPGGFKVVISKPGEEERPRTVEEMDLARPPVLNVSIPSWRIGTPRFSMRGTPFFFRGSSYAPTEEVRSSRASFFPSTHDGPSRDSFRKPSPFRGSKIRISKFDPNDPLNPASPTFLHPLRKTYMSGHVVIEPSMFDALTFKPMCDDRTIVRYSSTGAVTAATPARLVAEITSPSFLDYELLSDFFLTYRSFLEPSDLLRMLFARLRWAIDRSDEAGLVVRVRTFVALRHWILNYFIDDFLVDYDLRATFCNQLNGFAEELARDPKAQKVPLKILSELKKCWRRVCAQFWEGPEFDPSLGSDIPIQPGGTPENGDGNPDPATSWLQPPDGTAPQHENSEASQNQPPQTSLFVDMAKTTGYIDAIVAGDRPTTPDIDPETLDRDATASPTSLMSVDAVSCSFPTKAFKSNHPGGTYPAAHPVDQSAMQNSEHVATTPRAVVGKRVRAAQAHKRNGSLTDSLREHPTMTERALYKNAELLLALPYAGSLVRGDLLPPPQAVVDVQLPAGTAGARQTTLVQRPPSQLPKENGILASAMSGQGMKKLLGSTPGRRTGTRPSIRIDLLGAEVAEDFKRAVREDSQTGTEQHENRSATSQAQESTSNVQGGLSPMPRETSHHQAFSPNWQVLRPTSDMGITNGSQSIVIVDGSSLPENHPLVTGALPPVNPSVEAFAETFSQNAADPTPPTTPPGRMVGGTPRRSSYILGHQPVRHSHSADPLPPFIPDLATLGHASTHNDYPRPSLDDQSSRRLPLSGVGGIRRRNSDHVSYASSSHREDWQSHKRNAPSTTDTFHQPETIRSFDATTISEHSLDDGLSNKSAMPQPLRTLRRRPGGDLRAAKNVCDLDGHVLRRSRSAGSLTTYDESLRSSYIRSAEGPEEGYVDVAASDYSYERGEVFSLGALAEQNPKRDVSWVSTHDSKPVMRPSFEKEAQKLALIPDDADDDGGIETALLKLEGKYQRKKPPPPLVPVPKLSIDLGRPRENAPPADGVEIVKNGDRGLSKEEKQERRNVHIGEEAFQLAAAHNALLDISGRHGSQMARSFFSDDSRISYCPTPLLEQGLTDEARSKRTVTQEWTDRSVLQDPDDNDIETVQHRSIYDSQHQSFQFIQKTDSMDRIPPGKTMPLAEEQQQQQQQQQQQQQQRASLEQSFLNVESDNESDISTELSTEIVDYEDGQNPATIGLAVTTSNGQSITSRNQEPPAERSGSPQLTLLQALQMSPTTAYREKIQDRQNHFDKPLPPTPNPASSTPATSQTHLQYQHHHFLGARDAAAQSQPSLPNKYSVHLPFILAFDSDILAQQFTLVEKDALNEIDWKELIDMRWKNADQNNVNNVRSWVSFLRNTDARGVEVVIARFNIMVKWAISEIVLTQDLEERARCIIKFIHIAAHCRRYRNFATMSQITIALTSNEVSRLSRTWALVPPHDKRTLHDLEQLMSPTRNFYNLRAEMEAGSVTGKISKSGSSSSILADMACIPFVGIYTHDLLFNAQKPSEIASSPTTAPLVNFERCRTAAGIVKTLLRLLEASTLYAFQPIEGITERCLWMGALDDEEIRRLSERLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYI7</accession>
    <name>G0RYI7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CTHT_0006840</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dynactin 150 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691215.1">
        <property type="nucleotide sequence ID" value="XM_006691152.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0RYI7"/>
    <dbReference type="GeneID" id="18254722"/>
    <dbReference type="KEGG" id="cthr:CTHT_0006840"/>
    <dbReference type="eggNOG" id="KOG0971">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4568">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002523_1_1_1"/>
    <dbReference type="OMA" id="LFEMEPV"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000743">
        <property type="term" value="P:nuclear migration involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022157">
        <property type="entry name" value="Dynactin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF6">
        <property type="entry name" value="DYNACTIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12455">
        <property type="entry name" value="Dynactin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="10 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0243">Dynein</keyword>
    <keyword evidence="7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="15">
        <location>
            <begin position="23"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="71"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="343"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1072"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="127"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGS23973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1400" mass="153758" checksum="784A0343A34EA912" modified="2011-10-19" version="1">MDLVPGLRIQLSDGRTGTVRFVGHTAFAPDEWVGVELDEPTGKNDGSVHGDRYFDCEMGYGMFVRPNKVAPLVDEPAPPQQVTRPPSRPAMEKAGRKPGSRPSSLSSSTMGKPPPPDPNLAKRMSLNAPSPSPGQRPSTNRPPSGITSPTKQLAGTAPSSRVPSRSTTPASGSGLAKPGASSAMGGGMRPRPPSTSSRTMPPPPIPTAKQPTRAASGPASTAPTRTSSGGGNKLAAPKPGIRAPARHATSPSQQSLSGSETTARKLTRGGGASSGDEQRSQATKLSSDDDESSVPVSPVQTRAATLEKLSVGGVEKGGQGKAPSAGRPSAGPSPAPSITAAQAQAYQKEIEDLKAKLKVLEKKRMEDREKLNSLEKVKGERDKFERIIQTLQIKYQPQQAEIAELRRQLKEAEMRLHNVEEMQAEHETAMELATLDREMAEEMAEMYKTELEALKQKTEELELEVEILREENAELTKGTSPEERQSASWLQLEKTNERLREALIRLRDLSQEQEDELRAQIRSMEEDLREYEAVKEQYAVCKESLARSEAAVEDLREQLNNALGAEELIESLTEQNMNQAEEIKELRAIIDDLEALKEINDELEINHIQNEKEMQEEIELKDAIIVEQARQAAQQKEAMEDMEYTLSRFRELVTSLQSDLEDMRASHAVTEHESEQLASRSRAMMDLNMKLQISAAKAQAKAIDLELRRMEAQEAEQHLDIVKLFLPDSFQSDRDSVLALLRFKRLSFKANLVAGFLRERVNSFDSPGHEDDVFDGCAAIDRLTWVACMCDRFVAAISRCDLEQFARYEGALYELEPVERALNAWIDGLRRDDLKEKACADELTRTMALMSHLGEVHFAGDLQTFADDVHMRALLMQAQLESAAVALNAVKSMVQRAVQVDETNDEEGVLASQFAKRVDAAVTQTRSAKVIAQKTVRALEDLRARNLSLTPDSLDAFEQAESNAAQLADMSRRIGADLHKFLHDVDAPADFKATYVAVQNTIARTLDTSDSDPLSSYMTTLRVLTGQITDLSALATDLSHTAEFDPSPTPWSLRAAELRAAATAPADAEAQQARLREELGALRRQLAIREEDLSTAVVKIETLEARARDAAARAVKAKEVELELEKVRGELAQTAEVVATLEREVKVLEGERDKWKAAAATAGTARAVAAGAASKEQQVVSAAAVKELEKLRRDVEGLQAAVRFLREENRRVRGRECAGMAWLAEPLSKPSSSSTKLVSAELAGEGRAVLGELINLATRAKIPDLSAMSARRGAAEGAEGKEKEKEKAKIATWRPANTTPSYQLARAKEEWAVWREWERDVLRRGRELVAFEQRKKELVGSLGGERGTKGDRERRRGVARLQIRLPPVGGAKQVGREVRIWEVEGGQEWEGLVAGARVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYP5</accession>
    <name>G0RYP5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0007420</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS24031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691273.1">
        <property type="nucleotide sequence ID" value="XM_006691210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYP5"/>
    <dbReference type="STRING" id="759272.G0RYP5"/>
    <dbReference type="GeneID" id="18254780"/>
    <dbReference type="KEGG" id="cthr:CTHT_0007420"/>
    <dbReference type="eggNOG" id="KOG4629">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010480_0_1_1"/>
    <dbReference type="OMA" id="HSMHDVD"/>
    <dbReference type="OrthoDB" id="544685at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058650">
        <property type="entry name" value="Msy1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323:SF14">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25886">
        <property type="entry name" value="Msy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="459"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="403"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="699"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="794"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="700"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="715"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="741"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="823"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="855"/>
            <end position="876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS24031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="876" mass="96606" checksum="6B76BCD42BC3C4A2" modified="2011-10-19" version="1">MSLKSPRSPTHQGFRPLNSANNSRTEMHDIPLQPVRSNTSIRSRRGADDEKQGYFGPGPTQSNTNGPMVAGRRRIQKELKRAGSSDLNEEPASLNAMGRLYEKIVGFSVVTRYLVYVAPVALLLAAPLVVLPLTGDGDKDRIKLGDGKNHSLFQLFLWIEVSWLTLWAGKLVAHFLPGLFMFFCGVISAGTKKYATVLKGIEIPLSLFFWGLASWLSFKFMFLGANREWVTVVGRILLSLFLSSAVLLIEKSLVQLISITYHQRSFANRIQDSKRDIHLLSLMFDASRNLFPMYCDEFAEEDYIINGSLDIMLTGGKVSGKPMKLVGDMSRFGDKITSVFGNIASEITGKKVFNPNSAHSIVVEALERTRSSEALARRIWMSFVPEGKDTLTREDIIEAMGPSYREEAEESFDAIDADQNGDISLEEMVRKIVDIGKERKAIANSMKDISQALAAFDKVLLFVVFIICIIIFLAVFQSSFIGTLTTAGTALLSLSFVFAATTQEFLGSCIFLFVKHPYDVGDRVDIAGPEKEQLVVEKISLLYTVFTRIDKMQVVQIPNIVLNNLWIENVTRSKAMKETIDVNVSFDTSLEDIELLRQEMEKFVRAPENSRDFQPDLGISVGGVGDCDKLTLKIAIKHKSNWHNDAVRAARRNKFMCALTMALKRVPIYPPGGGSEPLGGPGNPSYSVAVSDEFAVSARKKAEQDKEAKRLANQLAEQTSASDSRSVHEQPTETPLERIPSANSPSALTTGFNLGRQESHTRGRRKPGESLPPTAVLGDDNAVSVGVTLTRTSSSISATRRDHRSFDIERNAGASPDWGSSNPYAGSSPSQQQQPNPYGPPIRQATEPAYLGVPSQQQGRDIIGGRQQGQQSPGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYZ4</accession>
    <name>G0RYZ4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DnaJ homologue subfamily C member 28 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0001110</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690664.1">
        <property type="nucleotide sequence ID" value="XM_006690601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYZ4"/>
    <dbReference type="GeneID" id="18254149"/>
    <dbReference type="KEGG" id="cthr:CTHT_0001110"/>
    <dbReference type="eggNOG" id="ENOG502RFG7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019422_1_1_1"/>
    <dbReference type="OMA" id="HNANSAF"/>
    <dbReference type="OrthoDB" id="1922282at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018961">
        <property type="entry name" value="DnaJ_homolog_subfam-C_membr-28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39394:SF1">
        <property type="entry name" value="DNAJ HOMOLOGUE SUBFAMILY C MEMBER 28 CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39394">
        <property type="entry name" value="YALI0E31793P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09350">
        <property type="entry name" value="DJC28_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DnaJ homologue subfamily C member 28 conserved" evidence="2">
        <location>
            <begin position="270"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="550" mass="59691" checksum="FCE4C83004CC2FE5" modified="2011-10-19" version="1">MAIAPFRCARCGHVLRSRALPVSSAPQSLRNFSQSSPWHDPSNESSSSQSSKPDENPTGKTESQAISKDTQPKTSDPPDPEPGAMTRLLEQATEDALFFGGRAGRRAIEEAGFSDELKAKLLEKVAAASFNAEHSAALTQAGLGSSKIPSSAGQGTRATATSKPWTGEEEMGDAVLRMLDDARKPLSAELRGKAAPPPPVDMRIRGAGNVSPGLRAANARERAQAYASMGMGKDTGLTEDEKEALKREFRERFSPGYRALPNSISGLAALANERIEDAMARGQFKNIPRGPGVERDTRADNPFIDTTEYIMNKMIKRQDLVPPWIDKQQELVRAAEDFRKRIRTEWKRHAIRLITSRGGSLEDKISRAKAYARAEELHNPSRRKIDQISVPSNTTDDSLKLHQSASSSSASQPSSSTDDAATALRPLRDPQWERSQRSYMELTITHLNSLTRSYNLMAPELAKKPYFSLERELSGCYADVAPLLADEIRTQALRPKESSGGFGGGGGGLLGLFGGGGGLSGTGGGGVTGEEGKEKQYGLRELWRDLWKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0S009</accession>
    <name>G0S009_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Suppressor protein spt23-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0008320</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691361.1">
        <property type="nucleotide sequence ID" value="XM_006691298.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S009"/>
    <dbReference type="GeneID" id="18254870"/>
    <dbReference type="KEGG" id="cthr:CTHT_0008320"/>
    <dbReference type="eggNOG" id="KOG3836">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002768_0_0_1"/>
    <dbReference type="OMA" id="HPMMRRI"/>
    <dbReference type="OrthoDB" id="71307at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00102">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057962">
        <property type="entry name" value="SPT23_MGA2_DBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25603">
        <property type="entry name" value="SPT23_MGA2_DBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1342"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="6">
        <location>
            <begin position="763"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="937"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="970"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="28"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="512"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="634"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1047"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1201"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1278"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="542"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="580"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="654"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1053"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1278"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1292"/>
            <end position="1302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS23170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1423" mass="153557" checksum="5926604B53AF6F5A" modified="2011-10-19" version="1">MPDPDFESQFDLEFNAGMLAGHHHTNEFIFDSDEGSPLPNRPASPGLDCGQVMNGTPEDYGSPSEALGLTSNTSSPHDSMFDSESSKRTSSTASTKYTFGDMSMDDNGSNNMKLDWNLTDDDFAAMMQPSFNMQASSSAPAQQDVRSPTDSPSPFTFSPDATNMQDAATISKASPQSDAGLSFQTACEDGVGAFTFRSPGPSMPSDVSTAPGASSFSPAALCLRPSQSIQSPPKYEFRGAQQPAAPIAPTMATFPGMHIFSAGPVSSSHSFYQDAMRIPIGRSYEHDQYGPGPYRLEVDANNSKSRVETQIQIRLRLSHLPPGVTKLHLPKHTISKTKLWAKPPAQPSPDMLELHTVLVCTSAMQVQKQKEAALQRAKAAARLVRAPPPPPNGEEEELKPQDGGEVKICEQCIGRERKRAGRKKLKNPEDELAWISDEHRRVIVFNTHEVKDWVLQNPPECGSRPFFQVEAPMRIACYCRHHAEKLGFRIIFTLTDHRGEIIAQTLSPSIMITDDHKNTSPKPQPGSRIRKLSPTRDEIPTQGVNGLTPSLESSPSLDLQAARRSSAGVPPMSTTSLETPQQQPVLAAAAQAARPISRPPSPSLAGGPAKRRKANKSVKIPGDVTMTRLDTAVPSGHRLHPSISSTGPLTPATSPFPPTPPATLPQTSDMSLFGSTAAPTETMPNPFGSASQTPGTGNSQLLLPNLSRSSSFANMNIPMFGAPGPARPNPVSSPNATRPVQATAGAAPPAPIIGQPRPQPQAQPVIFKVIPGEGPIAGGIEVTLMGQGFYNGMHVMFGDRQAPATTFWSSESLVCLLPPAAQAGMVPVTLKEQNPQMQNVATQWFRYVDDTEQQLLRTALMILGNKMTGGYENVADFARRIIKESGMSLPTGTTEMGAEGTTTRAIDSFENHLLKVLELMDITNTARKPRLNLRRSTGHTMLHLACILGLHRFVAGLLARGANPDLRDKGGYTALHLAALHDRPEIVRILINHGADTTLRTLSGLTAADVARSRECLRLILRFEQHKRTQSGSVPHSRIGSVTSLRSLRQEAMESSESEASPSTSSDEPKSEDDGIVFSDDSSSELATGRAVSDESGLRMRRGRSNVNTPREKSPAARPRRRGTEGAFGLPAAAMNLIKEQVAVHFQQLQQMMVPGLQYLPQFPQLPQFSQFSYLPQMPNMPPLPEYQAAVLQRLAAMIGAARPGPDQPGEPTTKSREASWGSSADADVQTPPPAYDELFPDQAGNSALDTKRASVAQAAADAVADAKCAAMFDQPVTSATTSTTTAADQRAEEDDDADDSASQELPVLLHVGRKSAITREQQVTLRRAHARNRKKLAWDRNLFLIWIPLLVLMVCVMIYHGLHGFMGTAPGWRPPVILPDALVAGKESQGNIANPALDVGTVADLRAPQMQEQHEAVPILNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0S091</accession>
    <name>G0S091_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0009190</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691443.1">
        <property type="nucleotide sequence ID" value="XM_006691380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S091"/>
    <dbReference type="STRING" id="759272.G0S091"/>
    <dbReference type="GeneID" id="18254957"/>
    <dbReference type="KEGG" id="cthr:CTHT_0009190"/>
    <dbReference type="eggNOG" id="ENOG502S23I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089740_0_0_1"/>
    <dbReference type="OMA" id="KHACDDA"/>
    <dbReference type="OrthoDB" id="29558at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009582">
        <property type="entry name" value="Spc2/SPCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 25 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06703">
        <property type="entry name" value="SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS23252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="235" mass="25347" checksum="D87FF3369BCBFCA3" modified="2011-10-19" version="1">MANSQDKINVYNLADLKNNSDDAIPNYLNSLGFRQSHRLIDVRLALGYSAFAVAAACFVWDHKYGFEATKYLTAVAVAVYTLLNGALTAWIMWVERGTVYVGEAPQTRETIRISTATKKNVPTYFVTVEITPKDGKGKKQTIEISRPFAEWFDAAGRFVAVPFQTMLATAVPVIGKSDPKRVATSAQGPGETSSTPAYTPQMLDLLAKASGSASGVTAEAVTGTDVKTGGKRRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0S7</accession>
    <name>G0S0S7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Chromosome segregation in meiosis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0011090</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Nucleic Acids Res." volume="48" first="6996" last="7004">
            <title>Crystal structure and interactions of the Tof1-Csm3 (Timeless-Tipin) fork protection complex.</title>
            <authorList>
                <person name="Grabarczyk D.B."/>
            </authorList>
            <dbReference type="PubMed" id="32469068"/>
            <dbReference type="DOI" id="10.1093/nar/gkaa456"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (3.10 ANGSTROMS) OF 48-157</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Plays an important role in the control of DNA replication and the maintenance of replication fork stability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CSM3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691629.1">
        <property type="nucleotide sequence ID" value="XM_006691566.1"/>
    </dbReference>
    <dbReference type="PDB" id="6XWX">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="B/D/F=48-157"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0S7"/>
    <dbReference type="SMR" id="G0S0S7"/>
    <dbReference type="STRING" id="759272.G0S0S7"/>
    <dbReference type="GeneID" id="18255147"/>
    <dbReference type="KEGG" id="cthr:CTHT_0011090"/>
    <dbReference type="eggNOG" id="KOG3004">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036204_1_0_1"/>
    <dbReference type="OMA" id="DANTCEN"/>
    <dbReference type="OrthoDB" id="437078at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012923">
        <property type="entry name" value="Csm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040038">
        <property type="entry name" value="TIPIN/Csm3/Swi3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13220">
        <property type="entry name" value="TIMELESS INTERACTING-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13220:SF11">
        <property type="entry name" value="TIMELESS-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07962">
        <property type="entry name" value="Swi3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="12" id="KW-0002">3D-structure</keyword>
    <keyword evidence="6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0236">DNA replication inhibitor</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromosome segregation in meiosis protein 3" evidence="9">
        <location>
            <begin position="69"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="187"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="266"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="333"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="266"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="345"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="464"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS22637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="6XWX"/>
        </source>
    </evidence>
    <sequence length="473" mass="50858" checksum="3C24A59B6AFBC689" modified="2011-10-19" version="1">MASSMRGRNLDPGNLSDWDDEDLFGPSSPKQGDKNDKTKNDKNSKQKTDALGIDKELNLKKKQRAPKVKLDDQRLLSEKGIPKLRKMAPRLKFKGKGHEFSDTARLLSFYQEWLDDLFPKATFLDALAMVEKAGHKTTVRNARLKWIDELRPKASFEDEGEDEHPIYTRDMPRPPEKVAPVFAKATGATTAQAASNDDGSGRERARTPLSQTIEDLLGDIYDATPRRNTTTNTAPARPEPDGDIPNDEDIDALMAEAKVQAAQNSGSIFGNGIRSNGSQPTRELNDDELDELMAEADAYGAQRATTAPETKRLQSTRELNDDELDGLMADAAAAEAEARARQRAARASQPASGPAANNSIFGDVKPVSPTDDYYGDDDDLDAIMVEAEALVSSQQAKPAEAGSADATTQAPEKPAAGGDDGDDLDALMAELEASAGSHNATLDEQKGASGGGTGQAQEKAGGDGEAEMEGLWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G0S164</accession>
    <name>G0S164_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0012490</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691766.1">
        <property type="nucleotide sequence ID" value="XM_006691703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S164"/>
    <dbReference type="GeneID" id="18255287"/>
    <dbReference type="KEGG" id="cthr:CTHT_0012490"/>
    <dbReference type="HOGENOM" id="CLU_305019_0_0_1"/>
    <dbReference type="OrthoDB" id="5417386at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="427"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="548"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="783"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="727"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="783"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="973" mass="109739" checksum="4CF98628CB8C8BAB" modified="2011-10-19" version="1">MDCLSNNRGIRVRRETVTVHSDDRPSHRRTPSQVTTTILSGTAGHQTHPSYHFESFLLDDASSSTDNLVNVPVPRVPNQNQSRQSIKGRKRDSLRDLIDFFRNTSRAPENLKSIPDLPAQAMADPECNPKRKLSLWRGLGRKPWKSENGNRNQKQQQQQQQQRRWSKLLRLPDSAVTSTTINGHKHIAISIPIEHDNLDLLRHNNNINTKQDPVRPRRTIKVDHNHNVTVSVPPRRRPRPLSEPLPRGSSINGADDLLKLVLDPHEARQPHQAPAPRFSATASMDDFDEQQHSRRAEVSVRARARGGGPVPAQHHVSYDHQLTDLLDQQGPVFPYTLPTALVIAQSDPAADTSLDNAHRRRLPLLRRQRGLCIRRPQSAYSLDALDTLHTIMDRSYLCKSPSVADSSDSDSSETILSDTVSVSIPSPHLSAECLGDDTPAQDPAQHGANPTATKCGDCSWIAISPVLETTRNPDELYQRDDGQVLRLENRESHGLLLGSSFRPSRPISLQSFSAISSLELPPPQQPQQAQQAQCRPVLRITPVQIIADLPPTPDSLDESRSTTPEFAAAAPSPTVPRILRSPRRKPRTLDLRAQANESPTSQPSPTHEIQSLKDLTFPRLLPPPDIDPNKPISPHRILATIPPNHNHQDYFSPFAPSPLPSPLVSNDGLAVDTSSPNRDSIGGGLLAGENFMGSLITRLDRLEKILSGDIRWAVVRDWDGEVRRARMKERERIREQERKEQERIREQERIREKERIKKQEKLKEEERVREQERLREQQRVKAQKRLEEYERPKPAKPGNSKSGKTMAWWKTGEQGIIGTEAETSCEVGDDERKEVRFSLELPVEQNGQQESIPREGQRTLHSWYKSTSTLGVERDEPLIQLPGPRDLLSFREHEELRKRAGSPMKHGGFEALLGENNKTGQTQIEVVIPERRSSLAGQQQHVEGRKRDLSDRDGLEKIAKVMNELVLGFDEVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1B0</accession>
    <name>G0S1B0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Altered inheritance of mitochondria protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">AIM11</name>
        <name evidence="6" type="ORF">CTHT_0012960</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AIM11 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691812.1">
        <property type="nucleotide sequence ID" value="XM_006691749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1B0"/>
    <dbReference type="GeneID" id="18255334"/>
    <dbReference type="KEGG" id="cthr:CTHT_0012960"/>
    <dbReference type="eggNOG" id="ENOG502S3SI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084856_0_0_1"/>
    <dbReference type="OMA" id="TNPHEYF"/>
    <dbReference type="OrthoDB" id="3558022at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038814">
        <property type="entry name" value="AIM11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39136">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39136:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="17"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS22820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="213" mass="22968" checksum="B3F5E25639ADB046" modified="2011-10-19" version="1">MFFSRWLKSMVLGEESDVKPAAGPQGTASTSPAAPGATATLPAATQPITVQPTPRPAPHPRDEYPPVFSQRSLRQLSLFLGGAGFLYCSVFLTRRAIMRHRIASQLKFFQPNWTRGHTSANPPKRGDPLVAVEALNLATLNTVSFAIMMAGGISWAFNISSLEDLREITRRSLGGAAGMTDMEAEKEVAAWVAKTLGLELKADSAESDEPKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1E5</accession>
    <name>G0S1E5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Isovaleryl-CoA dehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0013310</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691847.1">
        <property type="nucleotide sequence ID" value="XM_006691784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1E5"/>
    <dbReference type="STRING" id="759272.G0S1E5"/>
    <dbReference type="GeneID" id="18255369"/>
    <dbReference type="KEGG" id="cthr:CTHT_0013310"/>
    <dbReference type="eggNOG" id="KOG0141">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_0_1_1"/>
    <dbReference type="OMA" id="CFITNSG"/>
    <dbReference type="OrthoDB" id="9988775at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008470">
        <property type="term" value="F:3-methylbutanoyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000001">
        <property type="entry name" value="Acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000021">
        <property type="entry name" value="Isovaleryl-CoA dehydrogenase IvdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000003">
        <property type="entry name" value="isovaleryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF18">
        <property type="entry name" value="ISOVALERYL-COENZYME A DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016578">
        <property type="entry name" value="HsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="10">
        <location>
            <begin position="57"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="9">
        <location>
            <begin position="171"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="8">
        <location>
            <begin position="281"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="27"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS22855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="439" mass="47322" checksum="30D5924AB9F499BB" modified="2011-10-19" version="1">MSSLTRTLSRTLSRTVVRAPLSRPLPSLQPILPSLSQRRNASSKHPKGFTPPSQSDLAELRERVQDFVRREIPEEVAAATDKSNNFPADMWQKLGDAGLLGITADEDVGGLGMGYQAHCVVMEELSRASGSIALSYAAHSQLCVNQLQLNGTAEQKARFLPDLIAGRKVGALAMSESGSGSDVVSMRTRAVETEGGFLLTGSKMWITNGPDADLIIVYAKTKPDAGSKGITAFIVDTRAEGSKGFAVLRKLDKMGMRGSNTGELVFDNVFVPHSHVLGPVNGGVRVLMEGLDLERLVLSAGPLGLMQAALDVALPYAHSRKQFGTPIGQFQFIQGKLADMYTKLQASRSYTYATARAVDEDGVIRTHDCAGAILYAAERATECALDCIQILGGMGYTEDMPASRILRDAKLYEIGAGTSEVRRMVIGRAFNREYAHLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1F6</accession>
    <name>G0S1F6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Transaldolase</fullName>
            <ecNumber evidence="3 9">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0013420</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transaldolase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="3 9"/>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691858.1">
        <property type="nucleotide sequence ID" value="XM_006691795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1F6"/>
    <dbReference type="STRING" id="759272.G0S1F6"/>
    <dbReference type="GeneID" id="18255380"/>
    <dbReference type="KEGG" id="cthr:CTHT_0013420"/>
    <dbReference type="eggNOG" id="KOG2772">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047470_0_1_1"/>
    <dbReference type="OMA" id="THAEFLW"/>
    <dbReference type="OrthoDB" id="2015515at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00957">
        <property type="entry name" value="Transaldolase_TalAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000088">
        <property type="entry name" value="Transaldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004730">
        <property type="entry name" value="Transaldolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00874">
        <property type="entry name" value="talAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF18">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS22866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="321" mass="34800" checksum="02A8E8CBBAC69A5D" modified="2011-10-19" version="1">MANSLEQLKASGTVVVSDSGDFASIGKYKPQDATTNPSLILAATKKPEYAAVLDAAIAKAKAEGGDIQTQVDAALDHLLVQFGKRILEIIPGKVSTEVDAAFSFDTQKSVEKALHLIKAGVSKDRVLIKIASTWEGIKAAEILQRDHGVNCNLTLMFSIVQAIAAAEAGAYLISPFVGRILDWYKAHTGKSYSKEDDPGVASVKNIFNYYKKFGYKTIVMGASFRNTGEITELAGCDYLTISPALLEELLNSTEPVTKKLDASAAATLDIQKRSYINDEPSFRFDLNEDQMATEKLREGISKFAADAVVLKEIIRAKLEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1I6</accession>
    <name>G0S1I6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0013730</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691888.1">
        <property type="nucleotide sequence ID" value="XM_006691825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1I6"/>
    <dbReference type="GeneID" id="18255411"/>
    <dbReference type="KEGG" id="cthr:CTHT_0013730"/>
    <dbReference type="HOGENOM" id="CLU_572369_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="359"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="57"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="399"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="477" mass="54438" checksum="3A5AD42187D4FA11" modified="2011-10-19" version="1">MGENDNELLHELEQAQAQATYEIELLQDLGQTKAEAQTQAQGQPQDKPQPSYSIDLLEELEQTQAQAQAQASKLERVKHGTSVALDLLLKREEEVAKLQQKIKELEDAFVFECLRDPEKEEEIIRLKARIEELEEKERALINAEKKGQMEEGVVVAAMEQMGKCVEKWVNKWFGACKLVIDKEKTPEDVLHCLRRLLPQFHGLMSSPPRLVQAFVTVVLSKSIFMRMYPGVKQKYDNAIKDMLEVFKEYHIPPELVSTWRVNTTSMFELAPLEPATSTFVNNIAVSILNVLNIITRTEWTLDPETLQEQRERRFLDLRTIARHAVDWTRKFAEQKTVYRLVNPKITTLFMGEYMTDVDEEEPGTTVEGYNVLGLPGPSIPKPQQNVGSSKQQQTSESSSLKEGEIKEEPGNDKKSNELVTAENSESHVLGKRKREEAHPRRLKCVLWPGLAKVVVDEVPGVNDEKVEVILKARVWCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1J2</accession>
    <name>G0S1J2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0013790</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691894.1">
        <property type="nucleotide sequence ID" value="XM_006691831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1J2"/>
    <dbReference type="STRING" id="759272.G0S1J2"/>
    <dbReference type="GeneID" id="18255417"/>
    <dbReference type="KEGG" id="cthr:CTHT_0013790"/>
    <dbReference type="eggNOG" id="KOG3422">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078858_1_1_1"/>
    <dbReference type="OMA" id="MPGMYEF"/>
    <dbReference type="OrthoDB" id="268521at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.10:FF:000003">
        <property type="entry name" value="54S ribosomal protein L16, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_uL16_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_uL16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220:SF13">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="226"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="240"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS22902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="252" mass="27741" checksum="3C859DDED2BB411E" modified="2011-10-19" version="1">MRPNSSLALVSAFQALRISTPATQNAVRPAILSATTTGLLNFAKSSSPQLQSQHVRLFSVTAMREGNWLEPNIKRTQKMRKGRPRVPTGGSTKGTTVVWGDYGLRMCDHHRRISAAQLKVAADTIKQRLRGEKYRLYTRVAANVGVFVSGNEMRMGKGKGSFDHWAARVAVNQIIFEIRGQVHEKVIRDAFRLAGNKLPGQYEFVKKGDPPVVGITKLENGITLEDLKRPRKKLPPPPEAAESATETATASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-12-14" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1W0</accession>
    <name>G0S1W0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0015020</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS23020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692012.1">
        <property type="nucleotide sequence ID" value="XM_006691949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1W0"/>
    <dbReference type="GeneID" id="18255540"/>
    <dbReference type="KEGG" id="cthr:CTHT_0015020"/>
    <dbReference type="HOGENOM" id="CLU_1245220_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="158"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="222" mass="25899" checksum="D1BA5E5C83F23302" modified="2011-10-19" version="1">MSELPSNMNDFLKDVWPKVELTLIPESELLSISDDKTMHSDYQVLMTRRLKVVHATMDAVDNDISLVEFEFFTARNEAMRQIFEAGHDKVSANYLSWHVEYNAWEAIFGDSKPFPISKPSLGQDAHDDGKAGNASSLNRPAAVQQVDPEYGTFKVSFLKAWEQDLDKREQELMKHFEELKKKRKEFDKRQDDLIKNMELWKQKLRKWENKLISQAKDSSSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2023-02-22" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1W1</accession>
    <name>G0S1W1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0015030</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS23021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692013.1">
        <property type="nucleotide sequence ID" value="XM_006691950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1W1"/>
    <dbReference type="GeneID" id="18255541"/>
    <dbReference type="KEGG" id="cthr:CTHT_0015030"/>
    <dbReference type="HOGENOM" id="CLU_2793778_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS23021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="68" mass="7820" checksum="63F5E74E94A07E53" modified="2011-10-19" version="1">MISRHVNLRNLNAGDDLLEGWNFLDKRVIPEFGKPVEVKHPDYKILIDRHHEIFNAFSAATHNGNQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1X8</accession>
    <name>G0S1X8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0015220</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS23038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692030.1">
        <property type="nucleotide sequence ID" value="XM_006691967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1X8"/>
    <dbReference type="GeneID" id="18255560"/>
    <dbReference type="KEGG" id="cthr:CTHT_0015220"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013253_0_1_1"/>
    <dbReference type="OMA" id="WATHYED"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06097">
        <property type="entry name" value="Aspergillopepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034163">
        <property type="entry name" value="Aspergillopepsin-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF2">
        <property type="entry name" value="ASPERGILLOPEPSIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="8">
        <location>
            <begin position="21"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS23038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="399" mass="43895" checksum="B56ADD6386C9B01B" modified="2011-10-19" version="1">MTRFGQFGEINAESVRDDREYLSRVGFGTPPQWLDVDMDTGSSDVWIYTSDTKKNVAGDRKVFDIDKSKTARKVNNTSWMITYGDGSRAWGNVYTDHISLGNLTIQNATIESAISASASLTDDPDIDGIFGLAYALPSQTIPRQPTVLSAIVPQLAEPIFTVDLRWHSDKGAYTFGFVDKGRIKKGKQVYWTPVVGDSGFWQVDYADARVVDGKNGGKKNNDYIEENKEKKRMNGKLGSGNGWTAIVDTGTTLLLLDQETCATYYSKVPNATYNRSLGGLWTYPCQLSDTDTGAKGGKMAPYEHPKGSNPNKRGGAGTLPDFEIEFDNGFVATIPGVYMNYSSLPDDEETCMGGLQSFDMEDFGILGDVFLKAVYAVFDVEKGQVGFAEKELELEEKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G0S296</accession>
    <name>G0S296_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0016450</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692148.1">
        <property type="nucleotide sequence ID" value="XM_006692085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S296"/>
    <dbReference type="STRING" id="759272.G0S296"/>
    <dbReference type="GeneID" id="18255683"/>
    <dbReference type="KEGG" id="cthr:CTHT_0016450"/>
    <dbReference type="eggNOG" id="ENOG502QPKK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005247_0_1_1"/>
    <dbReference type="OMA" id="AGMMMQE"/>
    <dbReference type="OrthoDB" id="5376140at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1154" mass="133779" checksum="E1497AEA602A98FC" modified="2011-10-19" version="1">MSSALHDVGDKPEASSDHPGDSSENTSKAPSNPWTELESLKRKNRFFKRQITALRKATQKDPQFEPYERFLLAVKKETIEQWRKAQDPEIDEIFAPVSDEPRPDPFLEESSTPDASNGETVYERGVGVPGGRGFADLEDQDIFENIDEETRKLDPRNRTPEFPVLKYPQDPELQKALPRGFHDMTFEEQQEELWIVYSEKLLGTKWPLPPKGEKHREYVDDYPAYSPPKVLGMLYRWRARKWRAHEWRLARAIALNRSLRLPVLATQAFLRRHALLARRRGVAVKIETYLGTTEEWKARVAELEATTGITEADIKQWVWILSPQSGDLKIQRFLASECRKPFFLVMLLLAKDKTIKEPAVLMGLLKYIRENYILRERPEDEMNHPAYKEQGRAMSWWHFLVLLYRLVWHVREEWPAVFPVLAHMTAEFIQTIPVDSQSRSMTGAQARSVVLNKALQYFAWPARIRPLVHMEHNWAAQRYLLRLATSSEPPLVIMQNGYRAIRQVLIALSKTKGEARNVERASKTWPPYRRAVDGMDERRPPEDDLSRSSKAGILVREAGYADEFVDRTLSALGGSLFGDSPTIQSRALSPPFFYGSRAGFNIFVEWAAQVKATRNAREAWIVFLNPPEPGLRPDLRVYAEMFDKLFARPVSDHPAIRPGDVKEVFPVHDGNLSKFEIARLTPPTPDELYDMMLQDKLRPAGKCLAILVRNAPSKQEALRYLRDSPFAAYIDPLMNRLKWHDAESMKTLARLPPPIFNAWIRMLCRTHMRKTGEVRLETNKNGLSSQDTTAEMVINDPHLAGEDRVLERQIAKGYSILEAIALTRAFQTYNKRSAYGDKQPWHTIMEALAGPKVLYSRFGALFNPLETLTVFLEIYQRTTISKGVDPIAFEALCVMMRKTLMLSTFVVENGKLAPRQFIAYQSPVENQILRAHRLAREAFRDLVNPVPAEEATGESPDTQTAVEDIENNEMEQFYEEDDWPPKGLLRYNVTGRPLFRYMMALGCCGDWKEMVRLMDWILDGWDGEYIHEEAKSPHDIMYHYMIRTFAYFIRVGGYMVPHQEMERLRVKLEELRMTRECTWFWPTGEDLRRMEDEFETDLIIREKWTRLPQMIFFADPENKMEMLAELIPKGADKWVTKGQLTQEELVRELRRESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2S2</accession>
    <name>G0S2S2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative hexose transport-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0018270</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692324.1">
        <property type="nucleotide sequence ID" value="XM_006692261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2S2"/>
    <dbReference type="GeneID" id="18255865"/>
    <dbReference type="KEGG" id="cthr:CTHT_0018270"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="OMA" id="HMGEYDP"/>
    <dbReference type="OrthoDB" id="8120565at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF20">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="317"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="416"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="40"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="546"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="557"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS22305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="566" mass="62184" checksum="AEFAC9411913645D" modified="2011-10-19" version="1">MGGAPAGTAGIYDAALHKRQALMGKSGPSALWKNFRVFRIACFACIGGVLYGYNQGMFSGVLAMPAFEKHMGEYTTNQTKKGWLTAILELGAWLGTLLSGFLAEVLSRKYGVLVACAVFMLGVVVQATARTVGHNAILAGRFITGMGVGSLAMIIPIYNSEVAPPEVRGALVATQQLAICFGIMISFWIDYGTNFIGGTTLETQSDAAWLLPICLQLGPALILFFGMLFMPFSPRWLIHHGREDEARKVLASLRELDESHELVELEFLEIKAQSLFEKRTIAELFPDLREPTAWNVFKLQFVSIKKLFQTRAMFKRVVVATVTMFFQQWTGINAVLYYAPFIFKQLGLSSTTTSLLATGVVGIVMFIATIPSVLWIDRVGRKPVLTIGAVGMATCHIIIAVIVAKNINQWAEHVAAGWAAVCMVWLFVVHFGYSWGPCAWIIVAEIWPLSTRPYGVALGASSNWMNNFIVGQVTPDMLEGITYGTYILFGLLTYLGAAFIWFFVPETKRLTLEEMDVLFGSEGTAQADLERMEAINNEIGLTQLLRGEQGQNTSDAEQTKAEGEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2Z4</accession>
    <name>G0S2Z4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0019070</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006692333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2Z4"/>
    <dbReference type="GeneID" id="18255945"/>
    <dbReference type="KEGG" id="cthr:CTHT_0019070"/>
    <dbReference type="HOGENOM" id="CLU_1786633_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="82"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="145" mass="15702" checksum="B4AC8D072DAA1984" modified="2011-10-19" version="1">MCSQTSNNEQSREAASSNTSSAGVTGNEDNKDPFDVAGLLAALADALSRSEGRDAALAAIRAACSGTGKHPAQQQQRVGWRDVALLQRIEALERDNSALRKELIVIAELRNGIAELRDAVSKLRGHMETLSRQLDGVFINFYNMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G0S374</accession>
    <name>G0S374_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">OsmC-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0019950</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692476.1">
        <property type="nucleotide sequence ID" value="XM_006692413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S374"/>
    <dbReference type="GeneID" id="18256033"/>
    <dbReference type="KEGG" id="cthr:CTHT_0019950"/>
    <dbReference type="eggNOG" id="ENOG502SD2C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100275_0_0_1"/>
    <dbReference type="OMA" id="KSKWINE"/>
    <dbReference type="OrthoDB" id="3906254at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052924">
        <property type="entry name" value="OsmC/Ohr_hydroprdx_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35368">
        <property type="entry name" value="HYDROPEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35368:SF1">
        <property type="entry name" value="HYDROPEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="OsmC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS22457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="20074" checksum="49C4F1CA778BE066" modified="2011-10-19" version="1">MAARFALHGLCRPLANSTLLAKSQAIRLISTTKALQSTLPVAISGTGIGVLQHISVPGKTYSFTADTYPILGGEDSAPSPVVYSLAALSACNQVTGAVVAKDHGIRLGQWHVDVEAQLPTKTLVKGEEGNPNWESVKLKLRVQTDIPEGSAEFEKFVSEVERRCPITALFKRSGVKYESEWVNEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3C1</accession>
    <name>G0S3C1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alkaline ceramidase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0020480</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alkaline ceramidase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692523.1">
        <property type="nucleotide sequence ID" value="XM_006692460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3C1"/>
    <dbReference type="STRING" id="759272.G0S3C1"/>
    <dbReference type="GeneID" id="18256086"/>
    <dbReference type="KEGG" id="cthr:CTHT_0020480"/>
    <dbReference type="eggNOG" id="KOG2329">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063293_1_0_1"/>
    <dbReference type="OMA" id="PWAWLLE"/>
    <dbReference type="OrthoDB" id="187171at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008901">
        <property type="entry name" value="ACER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187:SF1">
        <property type="entry name" value="ALKALINE PHYTOCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05875">
        <property type="entry name" value="Ceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS22504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="33336" checksum="969E9EA042654565" modified="2011-10-19" version="1">MLGKHRSLAHFGLKDKQKHRLIRSFCEEDYAISYYLAEFINSISNIAYSQYSCSSSALLMPAPLTHPCVTVYLALRAMFCRQHNKRITLRADYLSLSLLILGINSFLFHATLRALPEFCDELGMLGLTWSLLQATLCMRQSSLARVRAITVVLAAAYIIFSAVYILYLPHIIYQVIAFTTALVGVLLRSQYLLHWVRPPFAEAKRREWNVRVWKAVGICIAGYVLWNVDLECCMWLRGLRAKVGLPWAWALELHGWWHVLTAVGAARVMDVVRDVWEEEERERKEGKKMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3E3</accession>
    <name>G0S3E3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxysterol binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0020700</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692545.1">
        <property type="nucleotide sequence ID" value="XM_006692482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3E3"/>
    <dbReference type="STRING" id="759272.G0S3E3"/>
    <dbReference type="GeneID" id="18256108"/>
    <dbReference type="KEGG" id="cthr:CTHT_0020700"/>
    <dbReference type="eggNOG" id="KOG2210">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012334_0_2_1"/>
    <dbReference type="OMA" id="WEPLFFK"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008142">
        <property type="term" value="F:oxysterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF92">
        <property type="entry name" value="OXYSTEROL BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="433" mass="48678" checksum="227E5021A9A2FC87" modified="2011-10-19" version="1">MATTTTTTMTTVSPTEHKSFSSHITSLLKFLSSFQGDLANATGPPSFLAPVSVTEVGCCWAQYPRLFSAAAFEPAPEKRALHVLRWFLSSLRTQLYTGIEFDKIRNGNGKNTTRGHSIRKPLNAFLGEVFLAEWKDDRAGAKTRLVSEQVSHHPPITAMHISDESAGVRADGYARVEMTFNGAVHVNQVGHAIYRVDRYNEEYLVPLPDVKVKGFLSGCLYPEITGTYHILGINGFAAEIKFWGESVLSRAKRNSFEAKIYRKGDSKKTAIYTVVGCWSEGGWTVKDAKTGQVIEKFDLDAPENQAIPITLLPVEEQDEWESRRAWAGVIEGLKTGNLSQVVEEKSKLEQAQRQMRAMEAVRGVTWEPLFFRSCSGEEHEVFRRMVKEWGLEREWKLEGERTKGVWRVNEEAVKGLKRPFRKGVSPTGYHETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3F6</accession>
    <name>G0S3F6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L-amino-acid oxidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0020840</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692558.1">
        <property type="nucleotide sequence ID" value="XM_006692495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3F6"/>
    <dbReference type="STRING" id="759272.G0S3F6"/>
    <dbReference type="GeneID" id="18256122"/>
    <dbReference type="KEGG" id="cthr:CTHT_0020840"/>
    <dbReference type="eggNOG" id="ENOG502QWMG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004498_8_2_1"/>
    <dbReference type="OMA" id="NCSHLMS"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001716">
        <property type="term" value="F:L-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF382">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408799" evidence="1">
        <location>
            <begin position="20"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="178"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="691" mass="76143" checksum="3F6DF31881ED810D" modified="2011-10-19" version="1">MTVLTGLKPLLLFGGYAAAASIGLPVKLETRSAVTSRLANVHYTAERSIDGPVTITYGSCSSSSPLEAHHVVGETEISKGCAKRLVWVLPEITESGGCLSAWNSAGTLVGRSVPQQLENRHLRRAQKRAESIPMDSTTGVETLGPWFDGVAALQNKQPGPVDVEEAKSKQVAIIGAGMSGLMSYLVLTQAGMKNVTILEASQRLGGRVHTEYLSGGPFDYSYQEMGPMRFPVTYQDPETKEKINITDHQLVFQLADELNKLNGYDKNLTVEFIKWVQSNPKGLVYKNGFKLPSGLPPTVEQIRADPSLSTPAKAQEESVKALSEELEAAMPDESFYTLIAKNMFKAHKEWTENGLKGLGGDTWSEFAYLMYHLNATLKDVDALGALNSHGSIWAELYEGLYFSAVDWVTIDGGLNRLPLAFAPHVAKDTYMGRKIERIQYTNDSKVQLVWRDVSSRPVKSVGLDTSRDLKNATFDYAIVGAPFSVVRSWRLPSLPTPITNAINRLPYQGACKVALEYSERFWEKAPYGIFGGCSTSTDIPGVGSICYPSYNFNGTGPATLLASYTQVGWVESLSEEEHVKYILDAITEIHGEETRKLFTGRYDRRCWNHDPLQAGAWANPTIGQHQMYIPEYFKTYGGLIFVGEHTSYTHAWIAAALESGIRGSVQLLLDLGLVDEAKAAVNKWMARWIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3N9</accession>
    <name>G0S3N9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">CTHT_0030070</name>
    </gene>
    <organism evidence="25">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:16638"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the C-terminal section; belongs to the chitin synthase family. Class V subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the N-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693461.1">
        <property type="nucleotide sequence ID" value="XM_006693398.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S3N9"/>
    <dbReference type="GeneID" id="18257045"/>
    <dbReference type="KEGG" id="cthr:CTHT_0030070"/>
    <dbReference type="eggNOG" id="KOG2571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4229">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000192_0_2_1"/>
    <dbReference type="OMA" id="LEMHHQI"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030436">
        <property type="term" value="P:asexual sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030448">
        <property type="term" value="P:hyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14879">
        <property type="entry name" value="MYSc_Myo17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000337">
        <property type="entry name" value="Chitin synthase 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000012">
        <property type="entry name" value="Chitin synthase ChsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000017">
        <property type="entry name" value="Chitin synthase ChsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000019">
        <property type="entry name" value="Chitin synthase ChsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036037">
        <property type="entry name" value="MYSc_Myo17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF45">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 18" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 18" id="KW-0505">Motor protein</keyword>
    <keyword evidence="10 18" id="KW-0518">Myosin</keyword>
    <keyword evidence="7 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="880"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="920"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1581"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1611"/>
            <end position="1634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1646"/>
            <end position="1665"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="22">
        <location>
            <begin position="1"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="21">
        <location>
            <begin position="943"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="domain" description="DEK-C" evidence="23">
        <location>
            <begin position="1816"/>
            <end position="1871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="594"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="782"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="613"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="635"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="104"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EGS21165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1874" mass="207894" checksum="41F1CF8A30FF0642" modified="2011-10-19" version="1">MTLTIPPLSGTGGGAHMQPSLPSLPAHLQSDTQITAHLASRFHVSIPCSRLSSHALVCINTYTASTKGDGSRDSCAMNAADDLAERALLRLGHRSENQAILFLGESGSGKTTVRSHLLTSILNRSSTPLSQKVSLAAYVFDTLTTTKTATTPTASKAGLFYELQYDTSASSSPVLIGAKLLDHRLERSRITNVPTGERNFHILYYLLAGTSPAEKSHLGFDGPANKRWKYLGHPTQLKVGINDAEGFQLFKTALRKLEFPRSEIAEICQILAAIMHLGQLEFETSANTTVQGDESGGFSHEGAQTTTVVKNKDVLGIIAAFLGVSSSELQTTLGYKTKMIHKERVTVLLDPAGARENANELARTLYSLLVAYVIEAINQKLCAAEDAISNTLSIIDFPGFQQQSSTGSALDQLLTNSACEFLYHLTLQHFFDRKADLLETEEVSVPATSYFDNSDAVKGLLKPGNGLLSILDDQTRRHRTDMQLLESLRKRFEGKNPAISVGAAQAKLPGSNFYTENTAATFTVKHFAGEVDYPVKGLVEENGEVISGDLLNLINSTKSDFVARLFGQEVLQTVVHPRERSTVMQAYVSSKPMRAPSIMSKRGRPATALAARRRQEAERDDASADHSDVGGDAGGSSKRAGGSSRNSEQGASGQFLAALENVKQSFTAQGTNCYFVFCLKPNDRRIANQFDSKCVRAQVQSFGIAEISQRLRSTDFSLFLPFGEFLGLCEADSVIVGSEREKVEAVVEEKRWPSNEVAIGSTGVFLSERLWMEIAQLGESYSQSGRYGPSETGDGGTSPADPFITSKERLALSGSALGEKKAALFGSNDIDARSDAGASAFGGGDMFKNLDTREQMAERSNEKEMVEVEEYKDSPSRKRWVFVVYLLTWFIPDFLIRVLGRMPRKDVRMAWREKLAINMIIWFSCLVAAFFIVVFPMLICPRQYVYSPEELSKYDGKDGRPAWAAIRGQIFDIGKFAPRHYPIYLPTKMLTQYAGMDITGLFPVQVSALCQGKDGSIDPAVQLSYKDTNVTGTANVLSSQDMNSKYHDFRWFTNDSRPDWFSQRMKMLRANYKVGNVGYSAQYVRTLSKKHSQVVAILNGRVYDMTMYITGGRRQQNPPGMPPPSDPNAIDFMEELVVQLFQQMSGEDITERWETLPLSAERKARMQLCLDNLFYVADVDTRASAKCKFSEYLVLAVSCLLASVIAFKFFAALQFGGKNMPENLDKFIMCQIPAYTEDEESLRRAIDSAARMKYDDKRKLLVIICDGMIIGQGNDRPTPRIVLDILGVSESVDPEPLSFESLGEGQKQHNMGKVYSGLYEVQGHIVPFLVVVKVGKPSEVSRPGNRGKRDSQMILMRFLNRVHYNLPMSPLELEMYHQIRNIIGVNPTFYEYLLQIDADTVVAPDSATRMVSAFVEDTRVIAVCGETALTNAKSSFVTMIQVYEYYISHNLSKAFESLFGSVTCLPGCFSMYRIRAADTGKPLFVSKEVVEAYATIRVDTLHMKNLLHLGEDRFLTTLLLKYHSRYKTKYIFTAHAWTIAPDSWKVFLSQRRRWINSTVHNLIELIPMNQLCGFCCFSMRFVVFIDLLSTVVQPVTIAYIVYLIVMVARNATVVPITAFVLLGAIYGLQAIIFIMRRKWEMVGWMILYVIALPVFSFALPLYAFWHMDDFNWGNTRVVAGENGKKIVISDEGKFDPSSIPRKKWEDYQAELWEAQTAREDTRSEVSGYSYATRPNVAMSEYGGYTPSRPGSIAGGIEGNYPPMPTAPSRMSLAASEMLMPGNRASQFGGSQFLGPHTSTTGTGHSQDVEMSNLAGMPSDDALLAEIREILRTADLMTVTKKGVKQELERRFGVPLDSRRQYINSATEAILSGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3S5</accession>
    <name>G0S3S5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dolichol-phosphate mannosyltransferase subunit 1</fullName>
            <ecNumber evidence="13">2.4.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0030470</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a di-trans,poly-cis-dolichyl phosphate + GDP-alpha-D-mannose = a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + GDP</text>
            <dbReference type="Rhea" id="RHEA:21184"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 13">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 13">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 13">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.83" evidence="13"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693497.1">
        <property type="nucleotide sequence ID" value="XM_006693434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3S5"/>
    <dbReference type="STRING" id="759272.G0S3S5"/>
    <dbReference type="GeneID" id="18257085"/>
    <dbReference type="KEGG" id="cthr:CTHT_0030470"/>
    <dbReference type="eggNOG" id="KOG2978">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_13_3_1"/>
    <dbReference type="OMA" id="KCFRREV"/>
    <dbReference type="OrthoDB" id="2603at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006720">
        <property type="term" value="P:isoprenoid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000036">
        <property type="entry name" value="Dolichol-phosphate mannosyltransferase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398:SF1">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="14">
        <location>
            <begin position="14"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS21201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="245" mass="27610" checksum="7BD4940988BBA96F" modified="2011-10-19" version="1">MTPTKSASEKDIYSVILPTFNERQNLPIVTWLLNRTFTEHNIDWELVIVDDGSPDGTQDVARQLVKVYHPHVQLQTRTGKLGLGTAYVHGLKFARGNFIIIMDADFSHHPKFIPQMIARQKECDYDIVTGTRYAGNGGVYGWDLKRKLTSKGANIFADTLLRPGVSDLTGSFRLYKRSVLEKLFESTDVRGFTMQMALAVTAKAKGFTIAEVPISFVDRVYGDSKLGGEEIVEYAKGVLKLWWQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3U5</accession>
    <name>G0S3U5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dynein heavy chain, cytoplasmic</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Dynein heavy chain, cytosolic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CTHT_0038920</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Consists of at least two heavy chains and a number of intermediate and light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS22007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694303.1">
        <property type="nucleotide sequence ID" value="XM_006694240.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S3U5"/>
    <dbReference type="GeneID" id="18257930"/>
    <dbReference type="KEGG" id="cthr:CTHT_0038920"/>
    <dbReference type="eggNOG" id="KOG3595">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000038_7_0_1"/>
    <dbReference type="OMA" id="NERQMTR"/>
    <dbReference type="OrthoDB" id="447173at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072384">
        <property type="term" value="P:organelle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000122">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000001">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000001">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000071">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000517">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.130:FF:000007">
        <property type="entry name" value="Dynein heavy chain, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000004">
        <property type="entry name" value="Dynein heavy chain, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000075">
        <property type="entry name" value="Dynein heavy chain, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000829">
        <property type="entry name" value="Dynein heavy chain, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054354">
        <property type="entry name" value="DYNC2H1-like_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF4">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22597">
        <property type="entry name" value="DYN_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
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            <dbReference type="PubMed" id="21784248"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Mem_transp_PIN-like"/>
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        <property type="entry name" value="AUXIN EFFLUX TRANSPORTER FAMILY PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AUXIN EFFLUX TRANSPORTER FAMILY PROTEIN (EUROFUNG)"/>
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    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="171"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS21334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="228" mass="24659" checksum="702EED9049F6CA22" modified="2011-10-19" version="1">MVSAGLQESFLSAIQASLSVLLVVFYGGLAAFLGFIDRINTKPISKICVRMFLPALLITKVGSQLHAASAHRYVIIFVWAIICHLISFFVGTAANFALGMPDWATVAILVNNTTSYPLLLITALEDTGVLESLVVTDETTKEAIERAKSYFLIFSTVSNCITFAVGPRLIDSENPPEEDEGDKPPHIPNGIRHSATATDLESNETHSASAQGRSPTSMDDSTKEMEQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0S501</accession>
    <name>G0S501_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0023580</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the MSS1-MTO1 complex that catalyzes the 5-carboxymethylaminomethyluridine (cmnm(5)U) modification at the 34th wobble position (U34) of mitochondrial tRNAs.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MnmG family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692822.1">
        <property type="nucleotide sequence ID" value="XM_006692759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S501"/>
    <dbReference type="STRING" id="759272.G0S501"/>
    <dbReference type="GeneID" id="18256396"/>
    <dbReference type="KEGG" id="cthr:CTHT_0023580"/>
    <dbReference type="eggNOG" id="KOG2311">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007831_2_2_1"/>
    <dbReference type="OMA" id="CNPAMGG"/>
    <dbReference type="OrthoDB" id="10266265at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070899">
        <property type="term" value="P:mitochondrial tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000145">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.570:FF:000001">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000002">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.570">
        <property type="entry name" value="GidA associated domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00129">
        <property type="entry name" value="MnmG_GidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049312">
        <property type="entry name" value="GIDA_C_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004416">
        <property type="entry name" value="MnmG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026904">
        <property type="entry name" value="MnmG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047001">
        <property type="entry name" value="MnmG_C_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044920">
        <property type="entry name" value="MnmG_C_subdom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00136">
        <property type="entry name" value="mnmG_gidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="GLUCOSE INHIBITED DIVISION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PROTEIN MTO1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21680">
        <property type="entry name" value="GIDA_C_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13932">
        <property type="entry name" value="SAM_GIDA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01228">
        <property type="entry name" value="GIDA_assoc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01280">
        <property type="entry name" value="GIDA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01281">
        <property type="entry name" value="GIDA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain" evidence="7">
        <location>
            <begin position="603"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS20526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="718" mass="78884" checksum="D8912BF7FE38A8D5" modified="2011-10-19" version="1">MTIKLGLFRGLGRPLLRPIQQHGSLCTPRIKRTFATVEDDFNARNFDVIVVGGGHAGSEASAAAARAGARTALITPDINNLGVCSCNPSFGGIGKGTILREIDALDGLAGRIIDKAGVQFRVLNRKKGPAVWGPRAQIDRSLYKKYMREELQSYPNLSVILGRVSDIVTADAHDDPNADGAKSKITGIRLESGETLTTNQVVITTGTFLGGEIHIGLESWPSGRIGEPPTYGLSKSLRAAGFKLGRLKTGTPPRLHKNSIKWNILEPQAGDEPPVPFSYMDDEVAVKDQLLCYATYTNTATHDIVRANLDKTIHIRETVKGPRYCPSLESKIIRFGDRERHIVWLEPEGFDTDVIYPNGLSMTVPAQAQEQLLRTIRGLEDVVMLQPGYGVEYDYVDPRSLKRSLETKAIRGLWLAGQINGTTGYEEAAGQGILAGINAGRASKGLPPITLSRADAYIGIMIDDLITKGVSEPYRMFTSRSEFRLSARPDNADVRLTPLGREAGVVSDARWSRFSDDRACAEHLLRLLRKTSLTVSQWRAAGLPINPVRDETRRRDGFEALRMPGVQPSHLRLILPFLKNHSSLSAASADFPDRIIDRVAIEAVYEPYVRMQESEAARLRRDEGLCLPPDLDYDSVFGLSIVEKQVLKEARPENIAQAKRIEGVTPAGLVRLLKYTTRGSSWDKSSAESVVVEGLDMSGVEDLEALDARSRVEDMKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G0S551</accession>
    <name>G0S551_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0032250</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693666.1">
        <property type="nucleotide sequence ID" value="XM_006693603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S551"/>
    <dbReference type="STRING" id="759272.G0S551"/>
    <dbReference type="GeneID" id="18257263"/>
    <dbReference type="KEGG" id="cthr:CTHT_0032250"/>
    <dbReference type="HOGENOM" id="CLU_841977_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="330" mass="37555" checksum="510E4D8ADF330526" modified="2011-10-19" version="1">MESLGPGRFIKIHWTWMYDLLQEIYFDPGLKRIDALREYKGMDMMLMSILGSTHFPERSTKPEESFYAVDIQGLQEEKDLFSPNSSFVLWNEDFQRFISAAITEGIAHSGSAAWNYVVTSYNDTALNLVEIGNVWPNITSFRASMGHGPIEQMFVEKTVTWTNGKMDYAYELNLQAKADTGSIDPNLEFKSPQEYLDHLQTFTDFHFEVERFGYGTGIRGTSRILALTLVGVYLSIITIYFLHITFISPYLFRDPLPTIQAWEDITNLILLAWNSKPTADDLLGRSTIDVQSRKAWGAEIGIRADETTGRTLLATARDGGSVLEKNVKYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G0S556</accession>
    <name>G0S556_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deoxyhypusine hydroxylase</fullName>
            <shortName evidence="9">DOHH</shortName>
            <ecNumber evidence="9">1.14.99.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Deoxyhypusine dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Deoxyhypusine monooxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LIA1</name>
        <name evidence="11" type="ORF">CTHT_0032300</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:14101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="Rhea" id="RHEA-COMP:12592"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="ChEBI" id="CHEBI:91175"/>
            <dbReference type="EC" id="1.14.99.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the deoxyhypusine hydroxylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.29" evidence="9"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693671.1">
        <property type="nucleotide sequence ID" value="XM_006693608.1"/>
    </dbReference>
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</entry>
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        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
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                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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        </lineage>
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        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
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                <person name="Flemming D."/>
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                <person name="Kunze R."/>
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            </authorList>
            <dbReference type="PubMed" id="21784248"/>
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        </source>
    </reference>
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    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="FNIP_N_dom"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RE13835P"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF14636"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="EGS21494.1"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="1276" mass="138707" checksum="2FE1782DF83E9405" modified="2011-10-19" version="1">MLGKLFNLGAGAGTPPLAQPPSQKTFPLESVQEDIHTRHLLFPDPQDLFEHRPNQLYPLSSISSASTHTTSNAFDYNADIELDIPDVRIIIMQDALSSVAASLLYDSQPPPPVPPTSLDRPSATAGSYVVQEPRKGPLSPRKPSISLPQRPMVIQSGSPRNRQGAFDRRPSVHSRNQGCIESESQRAWREYREELATFSSCIFGNSELMAYKGTSTKVHVVPSDVRQLDGGFGDGRNSIGRSTMRTSRLSQSFTSENQHMFTSPTSNMSLRSVDRKKVLITRLFPVNLPLDEDISPFSDDNIPDHSKAAEHINPKRFQPRQKRTPMYAVALIISLPPSNIHATPAANALRYGFKSSSSYAEQDSFPSSLSSTRRSGWTFVGQGGGGGQDLFDTSFGSETDDQIDAITQHWDIIMRTLSHLQTVVASTLFTMLRQADRAFPDPVSPLSTQVTRGSAGSSRRGDDGAAIKTTKTNAKHITLLPNCLLDNKQISAEVDAARTRVVAGIRASRVTTGQNRWPIWREEARWVARWAAGKEQGFFFFNLLTAFLATHTDWMQALCPPSYRRRHYLHQRTKAEEDASVPARTIIVSDNKIAARRLIFLLSAFLPASQLLPGPRAHRPSTPASLSALSQSPPSFVVPILKEDSLRRKIHRRTGSRMPSHSRNLSVQSHAARAGGSIPLPLAHLSMEGRHERRASDAASIRTTQLPIRGTDPRKTGAATTTTITPETSIPHFSGIYRADIFSQGRPGSSNSVAADDLKRLTRDESPGSQSSAGGERWSKSRWSTVISGIWKKESTAKPTAGQPGSSSASVNRRESVAAVSSKPAQATQVPGPPAAGQPGNANTFGTQPVSPKNSITPSAGHSSETYPPAEAPCLAPNPQRIPDPSSAFESPVKTSINLDDGVIDVDVPLPDFITSFESAVSSPSSSGYLSASGFGTGLDAFEQSCRFSADGDAPINVAGWLQHYHPDFILQAVPAQHGLIDHIKASMQAEPTPQLPPGTPTAEDGTTETWVDVASAIVADATTFTITRIRYRRLLRLGFGIDRQYQSSWSSPTRQGDIQLKDEFIEEPLVTFDETLIEAVEKVIATGYPGFGSSTTDLLVTETAMPTPTNSKLSSATSSRSNSKRRDDRAFFGMDNTASSTAGAETCPPSQTQSRSPLHTTGLAPPPSIVQEIPRSQCKTVLLSALEDIIHEVIAEREHRQEEEEVTRTLTGEQLGHGKDIEQGQQGNEGLGRERGRQMGGGVGGDKEREKAKERESPLREAVRAWIESVDITGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G0S655</accession>
    <name>G0S655_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cystathionine beta-lyase</fullName>
            <ecNumber evidence="3">4.4.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cysteine-S-conjugate beta-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CTHT_0034240</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L,L-cystathionine + H2O = L-homocysteine + pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13965"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:18121"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29256"/>
            <dbReference type="ChEBI" id="CHEBI:58717"/>
            <dbReference type="EC" id="4.4.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homocysteine from L-cystathionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.13" evidence="3"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693859.1">
        <property type="nucleotide sequence ID" value="XM_006693796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S655"/>
    <dbReference type="STRING" id="759272.G0S655"/>
    <dbReference type="GeneID" id="18257462"/>
    <dbReference type="KEGG" id="cthr:CTHT_0034240"/>
    <dbReference type="eggNOG" id="KOG0053">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018986_2_1_1"/>
    <dbReference type="OMA" id="NCIGATG"/>
    <dbReference type="OrthoDB" id="2545919at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047804">
        <property type="term" value="F:cysteine-S-conjugate beta-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000013">
        <property type="entry name" value="Cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000009">
        <property type="entry name" value="Cystathionine gamma-synthase homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006238">
        <property type="entry name" value="Cys_b_lyase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01329">
        <property type="entry name" value="cysta_beta_ly_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF50">
        <property type="entry name" value="CYSTATHIONINE BETA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 13 14" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="13">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGS21563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="433" mass="46965" checksum="5E8F00A288587869" modified="2011-10-19" version="1">MSAPSPSPATQATNKVFTRVDLDGHALPPSPAPSSPLSGRRRYALATELVHTETKDQYGASSIPIYQSATFKQTSANGGNEYDYTRSGNPTRTHLERHLAKIMNATRCLAVGSGMGALDVITRLLKPGDEVIAGDDLYGGTHRLLTYLKNNQGIVVYHVDTTNPDRVREVLSDKTAMVLLETPTNPLIKIVDIPTIARATHEASSKALVVVDNTMLSPLLANPLDFGADIVYESGTKYLSGHHDIMAGVIACNDPMLADKMYFTINATGCGLSPNDSFLLMRGVKTLAIRMEKQQANAQQIAEFLESHGFRVRYPGLKSHPQYDLHWSMARGAGAVLSFETGDVALSERIVESTRLWSISVSFGCVNSLISMPCRMSHASIDAKTRAERQMPEDLIRLCVGIEDVNDLIDDLSRAVSALTLQAAASLLPKATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6C1</accession>
    <name>G0S6C1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0026230</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693081.1">
        <property type="nucleotide sequence ID" value="XM_006693018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6C1"/>
    <dbReference type="STRING" id="759272.G0S6C1"/>
    <dbReference type="GeneID" id="18256661"/>
    <dbReference type="KEGG" id="cthr:CTHT_0026230"/>
    <dbReference type="HOGENOM" id="CLU_1454222_0_0_1"/>
    <dbReference type="OrthoDB" id="610462at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="42"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS20785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="186" mass="19928" checksum="43AF0291E685F4C7" modified="2011-10-19" version="1">MSAPWGAPDSATSPVLTLQPGQQLIGYPPSGPMGEVVTIEQRKIVILHLERDSLTEETVRQLLAEHAGIGSATSTASAGEGEDIEKIEIPINKDGRARGTSLVTFRTAELAFKAIAALDGRQIGSGSSGGRRLAARLASEGVSTGKGFGDRLGYRAGKPAYQQQNLLVDVRLQHRHPQLRHRMWLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0S703</accession>
    <name>G0S703_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0035670</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EGS21701.1"/>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF16">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17270)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS21701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="399" mass="43005" checksum="649CC96A6FD8DA0F" modified="2011-10-19" version="1">MRVIETEPANTPACLPYFSEPAEPTHEVRKSQGHGHRHHQIYSPIDREPQTHGADHVLTLKLVSAGFSFFVAGVNDGSVGALIPYFMREYGISTTVVSTVFISNFLGWLSAAISNTHLSQCLDLGAMLALGAACQAAGHALRPWGPPFALLVFSFWLITLGQAYQDAHANTFVVRVGSAAHHWLGFIHAMYMAGCLVAPFVATAVASSVGVGDRWHLFYVCPLGLGLANLVLVLVAFRDSVRLICTPKASSQDALPPDQGNTAATPSRHAAAANLIKITLCTPAMWLLSLFFFFFLGAAITAGGWLVEYLVVVRGGELAQMGYVPAGFNGGCLLGRLLLPEPTKRFGERRMIFLYAVLCVALQLLFWLVPNIIAASIAVSFLGFFSGPFFATSNPRILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0S771</accession>
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        <submittedName>
            <fullName evidence="9">Succinate dehydrogenase cytochrome-like protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="9" type="ORF">CTHT_0027650</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693222.1">
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    </dbReference>
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    <dbReference type="STRING" id="759272.G0S771"/>
    <dbReference type="GeneID" id="18256803"/>
    <dbReference type="KEGG" id="cthr:CTHT_0027650"/>
    <dbReference type="eggNOG" id="KOG0449">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094691_0_1_1"/>
    <dbReference type="OMA" id="LTWMLSG"/>
    <dbReference type="OrthoDB" id="588261at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="GOC"/>
    </dbReference>
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        <property type="term" value="F:electron transfer activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
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        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978:SF5">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0349">Heme</keyword>
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    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS20926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="188" mass="20535" checksum="32E61117DD46D21E" modified="2011-10-19" version="1">MIAQRAGTTVLRRVAGKPNTFFSANVAKFGLAQPLSTTQLRPVATQKITADEAAALLAKQRLNRPVSPHLAIYDKQQTWFGSSAWTRITGASLSGTLYLFATAYLAAPMLGWHLESASIAAAFGALPVAVKGGIKFLAAWPFAFHTFNGVKHLLYDMTIGFHRKQIVKQSWYLWGASLVTGMFLAFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G0S789</accession>
    <name>G0S789_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0027830</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S789"/>
    <dbReference type="GeneID" id="18256821"/>
    <dbReference type="KEGG" id="cthr:CTHT_0027830"/>
    <dbReference type="eggNOG" id="ENOG502QU2K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1677672_0_0_1"/>
    <dbReference type="OrthoDB" id="4867494at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="157" mass="17156" checksum="9C8C30953861A66D" modified="2011-10-19" version="1">MKHPYSFAAAFIGLAPAFSGAFKHKSSTTTTIAPETSTDFAPTPTFNPNPPICGAGFTYCGYILRDSQNFNEYDILQTYCSAHKHNCPNGKPRTDPYQALYLCVPPAAPEQPHGKSPVPPPRLPDQPNPLDVNYNDNDYHYAGGNDTNPYTLAYAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7D4</accession>
    <name>G0S7D4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0036460</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694074.1">
        <property type="nucleotide sequence ID" value="XM_006694011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7D4"/>
    <dbReference type="GeneID" id="18257684"/>
    <dbReference type="KEGG" id="cthr:CTHT_0036460"/>
    <dbReference type="HOGENOM" id="CLU_2542377_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="83" mass="8984" checksum="5198AA55D961ED64" modified="2011-10-19" version="1">MKLRRLRGTFSAKVCGTAGPTRQPEWKHIVPESPDLSKHGVKASAGGWILAEDVLVNPLAPGPSPSVPRCPMQDKRTATWLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7K8</accession>
    <name>G0S7K8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0036670</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694095.1">
        <property type="nucleotide sequence ID" value="XM_006694032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7K8"/>
    <dbReference type="STRING" id="759272.G0S7K8"/>
    <dbReference type="GeneID" id="18257705"/>
    <dbReference type="KEGG" id="cthr:CTHT_0036670"/>
    <dbReference type="eggNOG" id="ENOG502QSFH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027816_4_0_1"/>
    <dbReference type="OMA" id="DAGRLMF"/>
    <dbReference type="OrthoDB" id="655540at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF8">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="431"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="62"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS21799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="478" mass="51429" checksum="2B73957B9A92F213" modified="2011-10-19" version="1">MAAINSAMDMNAQTNGKKYGFDDQSPAVMDSSSDNEVGEIRPTAMTDYEKQKIAEGQAKFHQLGWKRLTIVLIVTAVALGSLSLPGAFATLGMVAGVILTVGIGLCALYSSYVIGQVKLKYPHISHYADAGRMMFGKVGYEVVGAMFVLQLIFTTGSHVLTGAIMFDNLSDNGACTIAFTVVSAIILFLVALPPSFSEMAILGYIDFASIIAAILITIIATGIRASDAPGGLAEVNWSAWPKPDLTLAEAFIAITNIVFAYSFALCQFSFMDEMHTPRDFSKAVIALGVFEIALYTLVGALVYRFVGADVRSPALLSAGPTVSKVAFGIAIPVIFISGSINTVVVARYLHERMFKNSVIRYINTPMGWATWVGLDAIITIIAWVIASAIPFFSDLLAICSALFISGFTFYFPSIMWFMFVKEGSWFSLKNMALSSANLVNLIVGLVVLGVGTYASVWDIDHRYDLGIVPDPFSCAPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7L9</accession>
    <name>G0S7L9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial fission process protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial 18 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0036800</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MTFP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694106.1">
        <property type="nucleotide sequence ID" value="XM_006694043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7L9"/>
    <dbReference type="GeneID" id="18257718"/>
    <dbReference type="KEGG" id="cthr:CTHT_0036800"/>
    <dbReference type="eggNOG" id="ENOG502RZGV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053720_0_1_1"/>
    <dbReference type="OMA" id="EHATEWI"/>
    <dbReference type="OrthoDB" id="424969at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019560">
        <property type="entry name" value="Mitochondrial_18_kDa_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001:SF2">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10558">
        <property type="entry name" value="MTP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="218"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS21810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="232" mass="26126" checksum="CC5CA4A205588BA9" modified="2011-10-19" version="1">MKLSSRNWLRDNSNVRYAAYASRFRTILLSAHRYVAYTSDIGESFRPVAHPYLVRAAYGVSWIYILGDVSYEGYKAYLHNQRVLNPNLELTAQQQQMFGLDVTSNGSSPAPTATSGKVPPLEDYRTVMLQRGIFQSIASMGLPAFTIHSVVRYSGRAMKNVKNATVRTWVPIGLGLSVVPFLPKIFDKPVENAVEWTFHKAFEKFGGHEAVGNSPLIGREKQLSERPKEKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7T7</accession>
    <name>G0S7T7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0028770</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693333.1">
        <property type="nucleotide sequence ID" value="XM_006693270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7T7"/>
    <dbReference type="GeneID" id="18256915"/>
    <dbReference type="KEGG" id="cthr:CTHT_0028770"/>
    <dbReference type="eggNOG" id="ENOG502RNHQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108572_0_0_1"/>
    <dbReference type="OMA" id="NRHEEHD"/>
    <dbReference type="OrthoDB" id="3437826at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="136" mass="14751" checksum="0B9FC618813EF3DE" modified="2011-10-19" version="1">MASLVAAARLQRRDSTDRRSKLLRASATVPTITTTTAGGNAIASVPTRRASELLTRVAIIAGSPSEPIVRSQPVPSRSPTLDSVDRQSDLSVSPVSQPDFGDMHEGFEARYFSFPSFDLYESSRREDEKDDGPKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>G0S855</accession>
    <name>G0S855_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0029430</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693398.1">
        <property type="nucleotide sequence ID" value="XM_006693335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S855"/>
    <dbReference type="GeneID" id="18256981"/>
    <dbReference type="KEGG" id="cthr:CTHT_0029430"/>
    <dbReference type="HOGENOM" id="CLU_524775_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="519" mass="58183" checksum="61F37E10B73467F0" modified="2011-10-19" version="1">MFSLLFGRPWGQQQSQPEEAAQAMPVHSSLAGSAAPETHSNVSTQASSAVAGGNSGYSVDACTTTITSPGSGSVNVGKPKPRDAWRPEAQEPTHPAGALFTQALPIAGAEKKLATEPDIPRSAPIDIPLAGSRDHPRLWHQQAMRGAFSDDIPRPPRRVHPQGGVRVVLPRLGTNQPSNLSAPTSVVEEGQFNQASPANEIQPLCIDDLPEAVINGEEEDKENHQYETVDLPDGRTHVVGGLVEETYEQQTILFAQQLPANHPEAQPGFGMSSARHPFFIWPPPDLHESNKELDRELAKYAPVLKPFDPNFLEKYVDGYTKETRAFCQAMNESNLEIVVQHQQVKALEQRCDMMEKHRTDLVALRCRPQNQRLFHFFGQRIRETDYEIQAVKKELEKRRRALKQTIAYAGELVANAGRWDFDLPNAIDEHRFREIKEAEEKERIGAEIEQGMLTGVYGPLKEQPKRTQDAVKDFTKRFFDEREKKKPREKTPNWRQQNLPVNTPSLLTALFAQEKAQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8A0</accession>
    <name>G0S8A0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycoside hydrolase family 76 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0038080</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694230.1">
        <property type="nucleotide sequence ID" value="XM_006694167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8A0"/>
    <dbReference type="STRING" id="759272.G0S8A0"/>
    <dbReference type="GeneID" id="18257846"/>
    <dbReference type="KEGG" id="cthr:CTHT_0038080"/>
    <dbReference type="eggNOG" id="ENOG502S9QC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028686_0_0_1"/>
    <dbReference type="OMA" id="YYVDWAQ"/>
    <dbReference type="OrthoDB" id="9984024at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053169">
        <property type="entry name" value="MUG_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791:SF1">
        <property type="entry name" value="ENDO MANNANASE, GH76 FAMILY (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 191 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS21934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="43011" checksum="CD0369263723D59D" modified="2011-10-19" version="1">MVAIRWSELAARAVFYLSTNPTSHADRVLQAAKALQGWYHGPSGLWTTTGWWNSANCLTVLADWALHVGSNTGDVNVPQIIATTFENAQKTHFTARKILYGDGLMQSTYTYDPVAKRGFSEFLNEFYDDEGWWALALIRSWDVTKENAYLDMAVRIFADMQNGTDTVCGGGIWWSKEKKYKNAISNELYLSVAASLANRIPNNKDHFLKIAKDQWTWFKNSGMINGNSLINDGLRIQEDGKCVNNGLPTWSYNQGVILGGLVELFHATADTSYLADAVAIATAAITKLSDNTGIIHEVDRCEPNCGNDGPQFKGIFMRNLQYLTRVVPNPVFQGVIRRNAHSIWTNDRNEQNQLGIKWTGPPDLGKGPTAATHSSAMDVLVGALAISGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8N4</accession>
    <name>G0S8N4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA topoisomerase 2</fullName>
            <ecNumber evidence="5">5.6.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">DNA topoisomerase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CTHT_0038710</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the type II topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="5"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694290.1">
        <property type="nucleotide sequence ID" value="XM_006694227.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S8N4"/>
    <dbReference type="GeneID" id="18257909"/>
    <dbReference type="KEGG" id="cthr:CTHT_0038710"/>
    <dbReference type="eggNOG" id="KOG0355">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001935_2_0_1"/>
    <dbReference type="OMA" id="TWTQDFK"/>
    <dbReference type="OrthoDB" id="276498at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16930">
        <property type="entry name" value="HATPase_TopII-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03481">
        <property type="entry name" value="TopoIIA_Trans_ScTopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03365">
        <property type="entry name" value="TOPRIM_TopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.40:FF:000003">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000008">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000004">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.670:FF:000001">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.199.10:FF:000002">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="entry name" value="Topoisomerase II, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="entry name" value="Topoisomerase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050634">
        <property type="entry name" value="DNA_Topoisomerase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001154">
        <property type="entry name" value="TopoII_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031660">
        <property type="entry name" value="TOPRIM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034157">
        <property type="entry name" value="TOPRIM_TopoII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169:SF38">
        <property type="entry name" value="DNA TOPOISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169">
        <property type="entry name" value="DNA TOPOISOMERASE/GYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16898">
        <property type="entry name" value="TOPRIM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01158">
        <property type="entry name" value="TOPISMRASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00418">
        <property type="entry name" value="TPI2FAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="Type II DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52040">
        <property type="entry name" value="TOPO_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13 15 19" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="17">
        <location>
            <begin position="564"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IIA-type catalytic" evidence="18">
        <location>
            <begin position="817"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1195"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1297"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1408"/>
            <end position="1887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1195"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1451"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1465"/>
            <end position="1494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1514"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1540"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1570"/>
            <end position="1593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1605"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1620"/>
            <end position="1632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1706"/>
            <end position="1723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1730"/>
            <end position="1750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1778"/>
            <end position="1800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1810"/>
            <end position="1820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1830"/>
            <end position="1840"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="15">
        <location>
            <position position="907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGS21994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1887" mass="210817" checksum="3FD6C80ABB20D3A2" modified="2011-10-19" version="1">MASDSDSVFEDRYQSESDAWTPDEKPKLVAKKATAKQPKKLVQTTLTGSKTTGKKRPKPAGDDEDDDGNFSSTPPTSKKAKKAPAKKAKATGKALAEIENDSMQIDDAASGTADGDAAPAATTGKKKTATETYQKLTQLEHIIRRPDTYIGSVEKTDQKMWVFNKNEKMMENRTITYVPGLYKIFDEILVNAADNSQRDSSMTYIKVTIDRESGEISVENNGKGIPVEIHEKEQVWIPELIFGHLLTGSNYDDNEKKTVGGRNGYGAKLTNIFSKRFTIELQDSVNGKRYKQTWTDNMGNMEKAKITSNKSSDFVKVSFLPDYKRFGMENGIDDDLEALLYRRVYDMAGTVNGVKVYLNGEQLKINFKSYCELYARAIARERGDEATDGDKPPAAKVEFDQVRDKGRLWQIGFTVSDGTFQQVSFVNNIATTSGGTHVNYIADQICDALVKELNKRKKGHSLKPSHFRNHIFIFINCLIDNPAFTSQTKEQLTTKVSAFGSKCQLSEPFLKKIRQSEAIANIMAFADKKADKMLAKSDGNKRSRISNEKLVDANLAGTKRGHECTLILTEGDSARGLAVAGRAVLDPDRIGVFPLRGKMLNVRDASIDQIMKNKEIENIKKFLGLKHKQEYTDTKSLRYGHLMIMADQDLDGSHIKGLLINFLEVQFPSLLRIPGFFQEFITPVVKVWQGNNPKKPQNLKMFFNLPEYEQWKEEHKHELRKWKYKYLKGLGSSSNEDAQVYFKDLDRHLKRFEVMTDEESKMLELVFSKKKADARKEWLANFVPGTYLDSTTHTVKYKDFIDKELILFSMADNVRSIPSVVDGLKPGQRKVVYGAFKRNLVNDQKVAEFAGYISEVAAYHHGEQSLQQTIVGLAQNYVGSNNVNILEPSGNFGSRLAGGSDAASARYIHTRLSPFARKVFSKLDEPNLEYQFDDGNMIEPKVYVPIIPMVLVNGADGIGTGWSTGIPNYNPKDIVENLKRRMGRDESGDGVEKPFLPMTPWWRGWKGQVLPDGPNRWKFNGIIKQDETNPNEVHVTELPIRMWTDDFKARLEEILRAEKTPSFIKDYKEFNDHRTVHFVIEMEPKHMEAALKEGLIEKFKLSKIISATNLVAFDTQGKIKKYENPEEMLEEYYHYRLAMYTERKKHWLSVYDAEYRKLKNQYRFILEIIEGKLVINRKQKKILVKELRDRDYEPFPPNAEKKVKNTDEELNRDEASSDDEDAGGGVTARDYDYLLSMPVWSFTAERLEKLKGMIAAKKAEWNELNAKSEKDLWVEDLDAFMEEWEAQLKQDEENYHNVTKKGRRQSLKLGLGNAKGGRRRAGDDDDDDDYNPAAKKAKTAKATAATKVKQEKEVKEEKIEPKKTQERFAEKFAAKSVKVKDDLSDEDFALLQGGDNKVAVKKEPGTKSRFELSDSDDDFMDLGKPSAATAKKAAVKEEVDGDDGVVEVSRPRRAAAKKAKYTASSEEEEEEEEDDEDDSMEDFIVDDDEEEDVEEKPAAAAKKSLVSRKKVPSEEDDDEDFDMELSEKEKPKPAAKKPTASKDKAKVEEDHDDLSVEEIPAPPKKTASSKTKDSDASAESDKPSKSSKTRKDEDSDVIMEDAKPSRRAAAKAKARYVESSDSESDSDNDMDLGDVGSLVKGIGGGSSAAASNRLSLFSMSRPEDGSLSAKRLKPARKESKSSNFAEDDEHDDTNYEALAMSSPRKGPTTAAAGKKPADALADFLSDDDLPSAATKPSASSSTGATSKAKPLAVVPTQPKKRGRPLGSKNKPKDDPSSTTTKAAAKPKLKQTTLSPAAKAYAAKKAKASIDDDESGEDEFVDAPASPPPAAAKTRPGRAAAQKAKTTIVIDDDEEDDSILAGPSKKGPGRKRRESDDVFGLSSSEDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8V5</accession>
    <name>G0S8V5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0043560</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694751.1">
        <property type="nucleotide sequence ID" value="XM_006694688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8V5"/>
    <dbReference type="STRING" id="759272.G0S8V5"/>
    <dbReference type="GeneID" id="18258394"/>
    <dbReference type="KEGG" id="cthr:CTHT_0043560"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_0_1"/>
    <dbReference type="OMA" id="YRRCVNN"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000050">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS19866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="548" mass="63170" checksum="DDF4AAB863FD35BE" modified="2011-10-19" version="1">MITDQVIQLSRQYGPAAAEFLRQYWPGILAFCLVAWHVRNYFYNGLNKYPGPFLAHFTDWWRFFNVYGRRPELTHIALHKKYGPVVRLGPNSLSFADPDALKTIYGLNKGFIKQAVVKGKPMPSLFSTTDNDFHMQFRRCVNGAFAMSALVQYEPFVDNTTRLFLEQTKKLYIDNPQACDFTRWLQFYAFDVIGEITYSKRHGFIEKNEDVDGIVAYLTKLFLYVAPIGQIPLLDKLFLKNPIYLKLSDWGLIDATFPVAKFARARMSERLPELEREKEAKKQGKSILPTSETRTPDLLSKFIAAHEARPEFMTHNLVQTMAVSMAFAGSETTAISLSAVFYFLLRNPAAMARLRKEIDDAARAGLFSDYETGLVTWHEAQQLPYLDMCIKEAFRLHPAPGLPMERIVPKDGIEIAGHWIKGGTIVGCSAWVLHRDEKIFGERVDEYWPERWEPKGPEDEGRVKVMNGMMLQFGMGSRTCIGKNISLLEIYKLVPTMLRRFEITFDDPNREWEIVNAWFVKQHNFITQFELRPLVLPDEGFLTSEKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8V6</accession>
    <name>G0S8V6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0043570</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694752.1">
        <property type="nucleotide sequence ID" value="XM_006694689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8V6"/>
    <dbReference type="GeneID" id="18258395"/>
    <dbReference type="KEGG" id="cthr:CTHT_0043570"/>
    <dbReference type="HOGENOM" id="CLU_1594337_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="167" mass="18293" checksum="87A891022491CD4B" modified="2011-10-19" version="1">MTASAADTTATRREACPSEVMGYSRTLNWSSPPSKPSSSSSSSTSSLPRSHTPPSSRSPSILRPAPQHLRKLASYYPSPNRPLPAFSTRLYHLFPFICHSVLIPGCKTAWREQLCIEKIWCEEGAKYGSGRQSKLGNVRKTGKKPSSEVDKNVTPEGAVAKENKDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G0S909</accession>
    <name>G0S909_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative chromatin structure-remodeling complex protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0044130</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694805.1">
        <property type="nucleotide sequence ID" value="XM_006694742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S909"/>
    <dbReference type="STRING" id="759272.G0S909"/>
    <dbReference type="GeneID" id="18258451"/>
    <dbReference type="KEGG" id="cthr:CTHT_0044130"/>
    <dbReference type="eggNOG" id="ENOG502QVTM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008152_1_0_1"/>
    <dbReference type="OMA" id="DKYKFDS"/>
    <dbReference type="OrthoDB" id="338531at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.60:FF:000021">
        <property type="entry name" value="Chromatin structure-remodeling complex subunit rsc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052406">
        <property type="entry name" value="Chromatin_Remodeling_Comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970:SF14">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ARID" evidence="6">
        <location>
            <begin position="15"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="RFX-type winged-helix" evidence="7">
        <location>
            <begin position="658"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="138"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="842"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="945"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="845"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="945"/>
            <end position="955"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS19920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1025" mass="115424" checksum="0DDB004FBEFC21E1" modified="2011-10-19" version="1">MAPAKPTIEHTVDRTPEYEKFIEELRAFHEKRGTNFDPEPKMGNTTVDLLKLFKYIVAHGGYDKVSEEKLMWRKMCEGLGLMRHNAPADAYTLKQIFYKNLAAYEIKTIHNKEPPPPEILEFTTAKGGSLLTRTLETYQVKNKQQPAEREGSNTEEGTPSRENQSAPTSTRASRGLREAPPPRVIFQPDTGPSRTRHSSNQHHNQQHSSNSGSNSQNQSQNQGQASSQTHSGTATPSHQGHPHATRGNASHTYNPPGPDAMNPVLQSYQPPPIQQVPLRIVDTPASNPELFARKQRQLRYPQPSAPNPGALVRATLGATALEGPNIYERCLLALRSSLRAEQAFALNHLVKISYERGDKYKFSQFSGLAEGLTEFALGVTKLFYGVEMFISHDFDLDCDDPTALDGINGTDDLDRRLAEVKKVNPDIQDSIQPAEFADQLTLINEAVLTIRNMVMLPDNAWFLSEYPPVKDLLVIILHLPEMDMLVELKHLALEIAEQLTPYMLLSESDPLYFIMMRTLERSEDRGMILSALRALGRIAMQHPTETNKLKGVGQHPNILPKMASWLLLNDDELLDACLDFLYQYTAEPDNIDLMLRTINVDHVVAHLVRLLSHGAKRSQREIVLKAAQVAYEAAPEQILALPKDLQERLLAMEEPDRCQAWLRCLFEEDPGSHVTQIAIWQAYNGAFAEALKMQGRPMIGAQEYIKNISNVYQSGGAQVVREQGPTGEIQKFIMSGIRPRSRPIALDGRSYLKCHWKYDGPTPPGIPVPQHCGSWHLTAETMWRHILVDHLREPITSDGKFQNREAAFSCHWDGCTKYRTPTKQRLAQLMAHVKTHLRAEEAQQHKMSQLTGPNDPNQPLTASPTVSKRHPPHQPHASRQGRVIRPATTITITYEETASARDERNPNAPPQAAGIPLSAVLILRNIARNVPHTNLEREERERAAEAAGQGEQQAQVVVSNDREKEIDDDAGSRIKAIWNERLFRPVLPRLWEVFTENRLLAPYVASLFSLLERDDRDYSSEGYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9E4</accession>
    <name>G0S9E4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoglycerate mutase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0045550</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694940.1">
        <property type="nucleotide sequence ID" value="XM_006694877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9E4"/>
    <dbReference type="GeneID" id="18258593"/>
    <dbReference type="KEGG" id="cthr:CTHT_0045550"/>
    <dbReference type="eggNOG" id="KOG4754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039184_1_2_1"/>
    <dbReference type="OMA" id="NSAKPCD"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF24">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS20055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="24040" checksum="81CA22E6F49620EC" modified="2011-10-19" version="1">MAPTVILVRHAQGLHDPELTELGRDQCRQVRDKLVPRIPKDFDVGLIIVSPMKRTIQTALLMFGELIERGVPIMAHAGWQENGVQPCDIGSSIDELKAMFPQVDFSQVDPVFPDKSSPEAAFYHETKSAIINRGQTVLIELRERPEKAVIVVSHSGFLRLGCTGHWFMNADWRVFEFEEGEEVKLRQWEETKAGGMGWSWEETVPLGHGLPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9M6</accession>
    <name>G0S9M6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="10">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0046440</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="10"/>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695022.1">
        <property type="nucleotide sequence ID" value="XM_006694959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9M6"/>
    <dbReference type="STRING" id="759272.G0S9M6"/>
    <dbReference type="GeneID" id="18258682"/>
    <dbReference type="KEGG" id="cthr:CTHT_0046440"/>
    <dbReference type="eggNOG" id="KOG3996">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048602_0_0_1"/>
    <dbReference type="OMA" id="KARFWLF"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
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        <citation type="journal article" date="2017" name="Nat. Struct. Mol. Biol." volume="24" first="954" last="964">
            <title>3.2-A-resolution structure of the 90S preribosome before A1 pre-rRNA cleavage.</title>
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        <citation type="journal article" date="2019" name="Mol. Cell" volume="75" first="1256" last="1269.e7">
            <title>Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration.</title>
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                <person name="Bassler J."/>
                <person name="Fischer P."/>
                <person name="Lau B."/>
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                <person name="Kunze R."/>
                <person name="Griesel S."/>
                <person name="Kallas M."/>
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    <reference evidence="10 11" key="4">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="476" last="476">
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            <title>Structural inventory of cotranslational protein folding by the eukaryotic RAC complex.</title>
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                <person name="Gese G.V."/>
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    <reference evidence="14" key="6">
        <citation type="journal article" date="2024" name="Nat. Commun." volume="15" first="716" last="716">
            <title>Methionine aminopeptidase 2 and its autoproteolysis product have different binding sites on the ribosome.</title>
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                <person name="Klein M.A."/>
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                <person name="Kisonaite M."/>
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        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.10 ANGSTROMS)</scope>
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        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS28 family.</text>
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    <sequence length="68" mass="7727" checksum="6EF4721FCC2515AD" modified="2011-10-19" version="1">MDSSKAPVKFVKVTRVLGRTGSRGGVTQVRVEFMDDTTRSIIRNVKGPVRENDILVLLESEREARRLR</sequence>
</entry>
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        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
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                <person name="Kunze R."/>
                <person name="Devos D.P."/>
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            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694452.1">
        <property type="nucleotide sequence ID" value="XM_006694389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9Z5"/>
    <dbReference type="STRING" id="759272.G0S9Z5"/>
    <dbReference type="GeneID" id="18258082"/>
    <dbReference type="KEGG" id="cthr:CTHT_0040440"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009666_3_1_1"/>
    <dbReference type="OMA" id="IHHAAIM"/>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.10:FF:000001">
        <property type="entry name" value="APSES transcription factor (MbpA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF15">
        <property type="entry name" value="TRANSCRIPTION FACTOR MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0183">Conidiation</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="10">
        <location>
            <begin position="17"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="257"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="379"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="116"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="425"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="579"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="487"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="579"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS19567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="706" mass="79114" checksum="133A67ABDB0BE045" modified="2011-10-19" version="1">MGAIGPIMPDDHPLTGIYSATYSNIPVYEFQFGPDLKEHVMRRRQDDWINATHILKAAGFDKPARTRILEREVQKDVHEKVQGGYGKYQGTWIPLEQGQLLAQRNNVYERLRPIFEFEPGPESPPPAPRHTSKPKAPKSRPAVPKWNSASAHASSHAHDDYDNAESALNDDDTPDNLTVASASYMAEDDRYDAAPHYASTGHRKRKREEMLQDLTEQQHAMYGDELLDYFLLSRNEQNVMRPEPPPNFQPDWPIDTDRHTALHWASAMGDVEVIKQLKRFNASLDARNVRGETPFMRAVHFTNCYEKQTFPLVMKELFSTVDARDNSGCTVIHHAAVMKSGRAMSQSCSRYYLDNILNKLQELRTPDEVQALLDAQDNDGNTALHLAAMQDARKCIRALLGRGAATDIPNNQGVRAEDLIRELNAAKSKQQSQSRAAAQRSSSPFGPDSAGQRRGSFSAEAGKLTPPPKFRSEAANAVTQRIEPLIIQRIRDLAQSYDAELNEKEEAEREAKRILNNAQAELQALKASIAELEARLEPEESAAKVEHEADELARRVLAYVTHQNRIMLREWVRREVGVNGETKENENPDGEKKSSDSDPSKQTEHMEDDDPQTRLSLAQDLYILLTTQRRHEQSYVSALGALGTGSQIDKYRHLLRACLPPEDQELLDENLEELIKMMEEEASSEGVTQGGGVIGPAASVVAQVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0SA14</accession>
    <name>G0SA14_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0040640</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694471.1">
        <property type="nucleotide sequence ID" value="XM_006694408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SA14"/>
    <dbReference type="STRING" id="759272.G0SA14"/>
    <dbReference type="GeneID" id="18258102"/>
    <dbReference type="KEGG" id="cthr:CTHT_0040640"/>
    <dbReference type="eggNOG" id="KOG2588">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041446_0_0_1"/>
    <dbReference type="OMA" id="MPNYSRT"/>
    <dbReference type="OrthoDB" id="2133190at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052099">
        <property type="entry name" value="Regulatory_TF_Diverse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="3">
        <location>
            <begin position="439"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="136"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="379"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="502"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="379"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS19586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="554" mass="61296" checksum="56BC5FFD92A252F5" modified="2011-10-19" version="1">MMDSDPLRHLEFFSMPNNQTVNPVDQGFLNVTAAPNPALWDPGLNVDTAGLSVSPSTAPTSLSLDSVTQPPPARGLTNLSQRDLAGLPGGQGSQVLPARGLTSRDGHERKRSRLSSESTPLDSVDYWIDFDKDDTTLPSIPEGAETESKTVGGSTKPQMDNRPTTTTTQASAPAPAPVFPQAFKTEEFIDDSALDNALSEEDAYSSINLTDQLSKVDSAPPQEVPPRLYSTPLSWEQPQPGIRMDSLIGLNSQTLNEAEQRQLIAIAMNPGPTLGGLGSNINLNFSGLSPGMPMTFGAGGNGLGNVNVANRVQRHVLPQQQLPSQQPQQQQQQQQQQHHHQQQQQQQQQQQQQQQQQQQQEQPQQQQQQQQQQQQQQGQQQHGQQQQGQGQQGPQQQQQGQQPQQQQSQTTTTSSQSRSAQQNQQKKQGATGDKPKPKGDRTAHNDIERKYRTNLKDKIAELRDAVPSLRQMMENAGEDDGTGTRVPKVSKGTVLTKATEYIHYLERRNKQIVQEHRELSRKLQAFEQLLNATARSQYAMPSYSRTLFDPRGFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAP5</accession>
    <name>G0SAP5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Piwi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0043020</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694702.1">
        <property type="nucleotide sequence ID" value="XM_006694639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAP5"/>
    <dbReference type="SMR" id="G0SAP5"/>
    <dbReference type="STRING" id="759272.G0SAP5"/>
    <dbReference type="GeneID" id="18258340"/>
    <dbReference type="KEGG" id="cthr:CTHT_0043020"/>
    <dbReference type="eggNOG" id="KOG1041">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004544_4_1_1"/>
    <dbReference type="OMA" id="HELCYLF"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="2">
        <location>
            <begin position="683"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS19817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1033" mass="114352" checksum="3E88843BE5BF5FF7" modified="2011-10-19" version="1">MSDRGRGGGRGRGRGEFRGGGGGRGGGRGGGRGGGGAGRGDFHGGGVRGGPVHVYSGRNGIPQPDPAITKLEDTYIQNYAGDITSKLGKLSLSDKPEFFPHRPAFGTEGNPVTLWANYFPLNIKKNTPLYQYSIRVLDKKVTKEQAEAVDVERSPQPQKGKGKGKGKGKEDSQKPAPPKEAKGQKREKVIQQALSGFPTHTVTTELKSQVVSVGPLKLPPDNIIEVTLAEAGSKSETWFVYFDGPQSMDLTGLVRFVEEQGDKGSEDVFPKYQAEINSLNVVLGHTPRSDPNTEVVGRSRFFALDKGRVEASLQLQSQLIDILRGYVQAVRPATGRLLLNVNVTHGIFRKGIKLDKLFKSMGLTGLNDPDKLSDQKLKHDLVRVNKVISKARIQCMVPDVNGKLIPVERTIAGLATTKDGPKKRGKDEKDEGNRPEFFFPDFPYTSPATTRFLLRPPKTPRDPPKGLKYGDKVTVEAYFKAKYNQQVNPGLPLINIGTSTEPVYFVAELCTLLPSSLKAKLSPKEQDAMIQFACRPPPANALSITQKGRELLRLDSNPLLEKFGIEVGKELITVEGRELTPPSLKYANDTKVPEEGGWLMKKVKVYKPNPIPINTWTFMTIGFNSHGKLQEDVHKFARWLRNDMGINIAPTPVPANGVKANSNEAAIHNAFARLDKDKKRPNFVLVILPEKSTSLYNMVKKTADVDFGFQTVCVVGNKFTKEGGQLGYFSNVGLKVNLKFGGVNHHVEDAVGLIKGGKTMFVGYDVTHPTNMSAAAAEKAPSIVGLVASIDRELGQWPAVVFQNPKGQEQVDKVFADHFKSRLRLWQNNNSGHLPQNIIIFRDGVSEGQFKMVLDVELPYIRDACRAVYPNGKQPRLTLIVSVKRHQTRFYPTDPTHAHHKSMSPKEGTIVDRGVTNVRYWDFFLQAHASLQGTARPAHYTVLLDEIFRADFGPQAANKLERLTHDMCYMYGRATKAVSICPPAYYADLVCTRARIHQSELFDDEGSSINDGERERITRRRVHERVKDSMYYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAU5</accession>
    <name>G0SAU5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RmlD-like substrate binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0047820</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695147.1">
        <property type="nucleotide sequence ID" value="XM_006695084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAU5"/>
    <dbReference type="STRING" id="759272.G0SAU5"/>
    <dbReference type="GeneID" id="18258820"/>
    <dbReference type="KEGG" id="cthr:CTHT_0047820"/>
    <dbReference type="eggNOG" id="KOG0747">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055718_0_0_1"/>
    <dbReference type="OMA" id="TIRMENR"/>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048269">
        <property type="term" value="C:methionine adenosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048270">
        <property type="term" value="F:methionine adenosyltransferase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05254">
        <property type="entry name" value="dTDP_HR_like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="DTDP-4-DEHYDRORHAMNOSE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491:SF4">
        <property type="entry name" value="METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD-like substrate binding" evidence="1">
        <location>
            <begin position="12"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="299" mass="33883" checksum="BEA8E5F3F0F6990C" modified="2011-10-19" version="1">MAGDADGTKKNRFLIWGGNGWIAGHLKTLLEQQGKEVYATTVRMENREEVLAELKRIQPTHVLNAAGCTGRPNVDWCEDNKEATMRSNVIGTLNLADCCWLLNIHCTVFATGCIYQYDEAHPWDGPGFKETDPPNFAGSFYSMTKAHVEEILKQYSNCLILRLRMPVSDDLHPRNFVTKITKYEYVVDIPNSNTILTDLLPASVLLAEHGETGVYNFTNPGAISHNEVLTLFREIVRPSFTWKNFSLEEQAKVLKAGRSNCKLDTTKLETKLKEYGYEVPEVHEAYRRCFERMKAAGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAV7</accession>
    <name>G0SAV7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Quinate repressor protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0047950</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the 2nd section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the shikimate kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695159.1">
        <property type="nucleotide sequence ID" value="XM_006695096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAV7"/>
    <dbReference type="STRING" id="759272.G0SAV7"/>
    <dbReference type="GeneID" id="18258833"/>
    <dbReference type="KEGG" id="cthr:CTHT_0047950"/>
    <dbReference type="eggNOG" id="KOG0692">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008871_0_1_1"/>
    <dbReference type="OMA" id="AVYSMIH"/>
    <dbReference type="OrthoDB" id="4415835at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000019">
        <property type="entry name" value="Quinate pathway repressor protein QutR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000386">
        <property type="entry name" value="Quinate repressor protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090">
        <property type="entry name" value="AROM/DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090:SF27">
        <property type="entry name" value="QUINATE REPRESSOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="8">
        <location>
            <begin position="459"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase" evidence="7">
        <location>
            <begin position="600"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="SDH C-terminal" evidence="9">
        <location>
            <begin position="746"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS19337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="808" mass="89402" checksum="30FBC6817522AF48" modified="2011-10-19" version="1">MASTAMKRKVIDLEKTFHTTTGFSSPGYKKLYGAAACQSRQVSILHDVLGKHKYNAIIVCSWVERGVQSALEQLCETHPVIYVLRDPEAIQNHLKLCSTQKARDILDASSTVFRRCTRFEFFNMSEEPSISGQAIDARLPSPTNDPDRPIAPYLTLKRAERHFLKFLSLILPCGAIPFIESAFPLATVPAEEREFTYAISLSLSTLLEKNVDVQEIETGADAIEVVVDDLVTGCASPLQSLALLSPQRASQISRVLAQIRRDTVIPILLHVVFPEAALTNDFWRTLYISYLCHGLRLAPDYITLDLRLNTSFLVEILSTKGTCKVIGNLQLVDPDPPPWNDSSWRFYYEKAQAVGCDLVRFTRKARNAAENFDVRLVQQLADSTSGPRLPIIAYNTGALGRWSACFNRILTSVNPYEYRNGKPLAHAESNIPIGPTLTAFEATQALYSSFYYEPMRLYVFGANVSYSLSPAMHNAALKACGIPHRYEPYSTGNIASIQQLVNDPHFAGASVGLPFKVEIISLTHTLSRHAKAIGAVNTLIPVRDLNPDGSIPEDGLLSNERNRAGPVKALYGENTDWIGIRACIRRGLSPANAVRPTSTGLVIGAGGMARAAVYAMLQLGVKHIFILNRTLANAQKLVSHFETLLSRNGLPLFSTGSDTDQRTTFHIIKSRDDPWPEGYKLPTMIVSCIPTHSVGGNPAPNFTLPEGWLGSPTGGVVLELEYKTLDSPLLEQVRKEAHRGWVAMDGLDLLPEQGFAQFELFTGRRAPRRLMRREVFKAYPDDPYGYGRGRSNLAQLQPRLNNIVAQVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G0SB06</accession>
    <name>G0SB06_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein transport protein SEC24</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Protein transport protein sec24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CTHT_0048450</name>
    </gene>
    <organism evidence="23">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695208.1">
        <property type="nucleotide sequence ID" value="XM_006695145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SB06"/>
    <dbReference type="STRING" id="759272.G0SB06"/>
    <dbReference type="GeneID" id="18258883"/>
    <dbReference type="KEGG" id="cthr:CTHT_0048450"/>
    <dbReference type="eggNOG" id="KOG1985">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004589_2_1_1"/>
    <dbReference type="OMA" id="AVECSKQ"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01479">
        <property type="entry name" value="Sec24-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041742">
        <property type="entry name" value="Sec24-like_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF39">
        <property type="entry name" value="SECRETORY 24AB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="18">
        <location>
            <begin position="260"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="19">
        <location>
            <begin position="334"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="21">
        <location>
            <begin position="581"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="20">
        <location>
            <begin position="675"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="17">
        <location>
            <begin position="806"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EGS19386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="942" mass="102515" checksum="2CF7EF636D155C39" modified="2011-10-19" version="1">MSAPYDGYGQQQPYPDPAQAYGAPAPGVPAPEQQPHHHHHEQHKKKKRAYAAEAFEIGSGANAAVGGQLPGGGQYGVPPAAAAAAAAPAYGAYPQPVQPELPPQPQYGMPQPAAPVGGYQPLEPYYPGAGASSVGIVAGLAGGIANMSLGPSPSSQPTPAQQQRVGPLNQLYPTDLLNQPFNVAELDLPPPPIILPPNCSVTPSPNANCNPKYVRSTLNAVPTSHSLLKKSKLPFALIIQPYASLHDLDDPVPIVQDQVISRCRRCRSYINPFVTFLDNGHRWRCNMCNLTNDVPQAFDWDAAAQKPVDRWQRHELNYSVVEFVAPQEYMVRPPQPLVYLFLFDVSYAAVSTGLLATSARTILDSLNRIPNADRRTRLGFMAVDSALHYFVIPKDGEENAETSMLVVSDLDEPFLPVPTELLVPLTECRNNIEAFLTKLPDMFANNQSNGSAMGPALRSGHKLIAPLGGKLVVLTASLPNLGVGKLEMREDKKLLGTSKEGSLLQTANSFYKSFAVECSKNQVSVDMFLFSSHYQDVASLSNLPRYTGGQTWFYPGWNAGRPEDAIKFASEFSDYLSSEIGLEAVLRVRATTGLRMNAFYGNFFNRSSDLCAFPAFPRDQCYVVEVAIDETIQKNVICLQTAVLHTTCNGERRIRVLTLALPTTNSLADVYASADQAAITTYFTHKAVERALSGSLDAARDALQSKIIELLTTFRKELGGGGGGALGAGLQFPANLRALPALFLGLIKHVGLRKSAQIPSDLRSAALCLLSTLPLPLLMQYIYPRMYSLHDMPDNAGLPDPETSQIVLPPAVNLSAERMVSYGLYLIDDGQTQFLWVGRDAVPQLLIDVFGVSDRSQLRVGKGSVPELDNEFNERVRNVILKSRDHRSRGVGSVTVPHLYIVREDGEPSLKLWAQTMLVEDRADQGVGLAQWMGILREKVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBA0</accession>
    <name>G0SBA0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0049470</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988044">
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
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    <sequence length="404" mass="44611" checksum="F98C823AB17306E4" modified="2011-10-19" version="1">MNPCRLPLTVRAVEPACRALLTPLAGTSSSTVTVTSAARLPSQDLAVGSQRRTIHQHARPMSAAAARQLPKQPVVLPGRTLIQKRAHSSRAMIHTPPPAPEQPLIHSLFEPVTSTFQYVVADPATNKAVIIDPVLDYDNVARTIKTHSADNILELIKKNGYEIVKILETHAHADHLTSAFYLQKKLEKMQGYKPGVGIGKRIGQVQRVFGERYGVSTDEYDGVFDTLFDDDEVFEIGSLRASAIHLPGHTPDHMGYRVGDSSGLADNIFCGDSLFHPQTLGTARCDFPGGSAEQLYYSGRMLLSLPDHVRIWVGHDYAEDGRQPEPWATVAEHRLYNRHLRDGITEKEFVQMRKERDRQLAAPRLLHESLQVNIRGGHLPKVNAAGMRTFAVPVQVQGEAASVL</sequence>
</entry>
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        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
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                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
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            <dbReference type="PubMed" id="21784248"/>
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            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
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        <property type="entry name" value="RTA1"/>
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        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
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    </dbReference>
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    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="40"/>
            <end position="62"/>
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    </feature>
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        </location>
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        <location>
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        </location>
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        </location>
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            <begin position="333"/>
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    </evidence>
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        </source>
    </evidence>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGS19516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="342" mass="37662" checksum="D118C079EFE7FE10" modified="2011-10-19" version="1">MESVPSLPPGWYPSYDTCPEVSPWCPVEATTLGYAPIKSLHIFLAAAYGVLGAVTLGLGILYQTWEFSLAVAVGCFLELIGYVGRARMGINPWDYDAFRMQIVAIILGPTLVCIGLYLTLRHIVIHLNRDLSRVRPRIYPTFFIPADISCLVIQGVGGGIAAAAETRSLLKHGNNLIMAGISLQVAVLAFFGIAAFDYLWRARRFFTSFPSIPSSDPATNEKHRAGALLWTNRKFRVWLIVLSIAYAALMVRCIYRIAEMAGGWGNEIMQDEPSFIVLESFMVLVACILLTMFPPGYFFPQMGRRWRRGGGRESTGSEREGESAMGSGSATEVEVEGMGEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBK5</accession>
    <name>G0SBK5_CHATD</name>
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        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0053900</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
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                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EGS18781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_006695663.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="cthr:CTHT_0053900"/>
    <dbReference type="eggNOG" id="ENOG502QVRM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005537_0_0_1"/>
    <dbReference type="OMA" id="LGANCPC"/>
    <dbReference type="OrthoDB" id="5315052at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058925">
        <property type="entry name" value="zf-C2H2_AcuF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF3">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26082">
        <property type="entry name" value="zf-C2H2_AcuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="880"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="947"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="988"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1230"/>
            <end position="1257"/>
        </location>
    </feature>
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        <location>
            <begin position="126"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="229"/>
        </location>
    </feature>
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        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="581"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="643"/>
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        </location>
    </feature>
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        <location>
            <begin position="662"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1015"/>
            <end position="1029"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGS18781.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="1257" mass="136840" checksum="3202C3D4EAE01628" modified="2011-10-19" version="1">MSSTYAVFPSTDQIEQSHGTLEQDSQQYQQYLSPSTPTYASRNSNLTAISPQLNNNITSPVSNQNTPAESIASIHYQSSEYDDNDIFCSVNFDAVERATPSFLDEQVDPLSVPQSPAGPEQASPYLEQTVSQATQQTLSYSPLSPDNAPSSARGYSSGADKEAPISQGMLSNSADASPMTPQNSSTTHPQQQSKLGPAPLTRETFANGHLGQPNITSPSHGINPTSPRITISHWPDDPDRETLASDDADKDKGSSGLPSTCFPRDESGRWIPNPTTGQGGVDPSQRTDEEVPSLNDYEKQQKEREQKERTQRMVNDWLHSFEPAAFAAGENPGTEEPTAASPTNSDDDGIPNHDVSLGHLTLNIPKPGEIFFTPFGRDFNDIDRDLLAQTAGPFSDKPVPIIRQPEKDEARYQPQTANEAIKKMNDQYDRFDTISRQATCGTGRFSLLEALDVVALGNALAQVKIREGEDDREEKPRRSTFAELLTFVENLTYREARNILHAWRTKQSAGPGANKRSRNESDGSSFHTESTMDKKDRRESQSKLNSIVASKSARFKKQSVPNIDTAVVGVGSSIAAVGTSHARTGSVSAAPPATSPKSPIRRSFSFTKPKDRFRSKSDVTAPGNISELLRKMGGPPVVNLGNPAAPVPDVTADPGIPSGAGTDDEDEDEDDDSASQDGEAGPSQETETKTESAKLIEEITPTMEGFRQHILRLNPYLVTHNQYLVDRLAHHQVIRYKQLLTARQKHLRAGTNCLSGSMCIAMGGRANILDAKGDPRSVNPLDGADGDVSPLEGAITQENFPEDIPMPPTNVLPAEFECQLCFATKKFQKPSDWTKHVHEDVQPFTCTWEHCPSPNKPFKRKADWLRHENEGHRHPEWWQCELQECNHICYRRDNFIQHLVREHKLPEPKIKSKAAVKKQPLVHTDPTLSKVEAWHHTTNALPNDEHCRFCGRSFPTWKRLTVHLAKHMEQISLPVLKLVAKQPLSEDTVISPVQDPPPRHFFPPKQESAHHTHQPQHQPNAFMPSSTIPHQGPLPRGSPGPIQGFPHQPQPFMYAIPSPPPAGGYDPAPTLYSPPAFSDPSHALAAQAQFFPSHPQTAQPSPVVNTHVFQSLNSQTAAAFSATPTPSTPVPPANAVFHHMSPMTPVSGVQATPVATTGAAYMPLSGVSMPVVGGTMSPELDPFPALGGMPGLHGMGDTNRMNGVMGVGNSLGLQQGAAAGLGLGVVGELEQQQGSISPSQVAGSRFYHHPASQQTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0SC37</accession>
    <name>G0SC37_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Methyltransferase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0055790</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695908.1">
        <property type="nucleotide sequence ID" value="XM_006695845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SC37"/>
    <dbReference type="STRING" id="759272.G0SC37"/>
    <dbReference type="GeneID" id="18259617"/>
    <dbReference type="KEGG" id="cthr:CTHT_0055790"/>
    <dbReference type="eggNOG" id="KOG1541">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055194_0_2_1"/>
    <dbReference type="OMA" id="WIQEKKE"/>
    <dbReference type="OrthoDB" id="2877at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000017">
        <property type="entry name" value="probable 18S rRNA (Guanine-N(7))-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039769">
        <property type="entry name" value="Bud23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022238">
        <property type="entry name" value="Bud23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734:SF0">
        <property type="entry name" value="18S RRNA (GUANINE-N(7))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12589">
        <property type="entry name" value="WBS_methylT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="9">
        <location>
            <begin position="52"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23 C-terminal" evidence="10">
        <location>
            <begin position="206"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS18963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="30321" checksum="B2787B0390EA9980" modified="2011-10-19" version="1">MSRPEDTLAADVHYNDAEARKYTTSSRIQNIQAAMTRRALELLNLKSPSLILDVGCGSGLSGEILSSVPPEEGGPHVWVGMDISASMLDVALQRDVEGDLLLSDIGQGVPFRPGTFDAAISISAIQWLCNADTSETSPAGRLTRFFNGLYAALKRGGMAVCQFYPKNDVQKQMITSAAIKAGFGAGLLEDDPGTKNVKVYLVLTVGSTAVQAKGGDITGVVEGMDNVEVLDNRKKAKPKSGKGEIKKGSKAWIIKKKEQMERKGKIVKRTSKYTGRSRGPKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>G0SC73</accession>
    <name>G0SC73_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0056190</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695944.1">
        <property type="nucleotide sequence ID" value="XM_006695881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SC73"/>
    <dbReference type="GeneID" id="18259657"/>
    <dbReference type="KEGG" id="cthr:CTHT_0056190"/>
    <dbReference type="HOGENOM" id="CLU_1586281_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="168" mass="18228" checksum="37339FA4FD9EE1AF" modified="2011-10-19" version="1">MADEENRDQPIWFWAHSIKCWVLRAYNPNPDANGSQPYSLHSHPMPTTLSTPADTVPPDPPPTDKPSSGSLGCPAAENGRHVRTPDRSRGPPVSDASTRPTRCAARPPPDENSSRRSVGSVSVIQRAVVHFGNLGLSTIYGELFQRISGPSNKTSQLRGTTALKMTTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCB7</accession>
    <name>G0SCB7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromatin modification-related protein EAF6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dipeptidyl-peptidase V</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CTHT_0056650</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EAF6 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S9C family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695988.1">
        <property type="nucleotide sequence ID" value="XM_006695925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCB7"/>
    <dbReference type="STRING" id="759272.G0SCB7"/>
    <dbReference type="GeneID" id="18259703"/>
    <dbReference type="KEGG" id="cthr:CTHT_0056650"/>
    <dbReference type="eggNOG" id="KOG2100">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008615_0_1_1"/>
    <dbReference type="OMA" id="LWYRTVI"/>
    <dbReference type="OrthoDB" id="416344at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000028">
        <property type="entry name" value="S9 family peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015418">
        <property type="entry name" value="Eaf6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776:SF13">
        <property type="entry name" value="DIPEPTIDYL-PEPTIDASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776">
        <property type="entry name" value="SERINE PEPTIDASE S9 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09340">
        <property type="entry name" value="NuA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="17">
        <location>
            <begin position="684"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="124"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="42"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGS19043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="908" mass="98721" checksum="2066D11F0754360F" modified="2011-10-19" version="1">MTETAAAAAAAGKSSGASVNGDSSTTPGVNSTIPAGAGIPFYEKQRQHLRELLNRRRLLERKLAAHEEMILAKETEYLESTPAGNIIVGFDNYTKGTSAAAAQRRKSGLTDQNRVFSRSSVSYNAAASTGDTPASTPGASHAPMPVSGNFPGRDGASAAGTPASTTGGGGGGSRSTASKKGKKSGNAGGVEDSETDGREAKKVRTSFEVLLSAPRRSAAVPNASGTRALYSVSTYSFEEHKKTIQHRVVDLKTGQTELLTDDSNVSEPVWLTDDEVLLLKSGDNGTTTLVVQSAENPNAEGYDITTISAPISNVKVRPLPNGSLAFVCVALTTPSGCLFNPETAEKPRSTAKVYTSLFVRHWDVWLSEHRNSLFYSTLEKRDDGSGPKWRLSYLVNALKGTGLSCPVPPFGGTGDFDVGTEGICFVAKDPGLDPAMYTKTDLYFVPLKTFTEIEPPKPVIVKTPGLEGYSQSPVFSRDGKKIAFTRMKSRQYESDKTRLMLVRDVHDLETPAEEFFTTEDGEGKWDLRPDAILWSKDDSTLYVTAECRARTLIFKVPADPTKATDLPEPISTPEGSVDNIQLLGVSSSGEDALLVTTTSLTDNSCYSTIHPTTGTITTLSSATKHGKTLGLSRSQVDSITFPGSDGSYDVHALVVRPSFFDPKKKYPLCMLIHGGPQGAWSDAWSTRWNPAVFAEQGYVVVAPNPTGSTGYGMEFENAITGQWGGRPYEDLVKCFEWIEQNMPEVDTSRAVAAGASYGGFMINWIQGHPLGRKFKALVCHDGVFSTLNQWCTEELFFPIHDFEGTLEENREGYERWDPARFISEWATPELIIHSELDYRLPVTEGLAAFNVLQAKKVPSKLLVFPDENHWVLKPENSLVWHREVLGWLNRWSGIADEQESNETSVVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCC5</accession>
    <name>G0SCC5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Peroxin-10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CTHT_0056730</name>
    </gene>
    <organism evidence="23">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695996.1">
        <property type="nucleotide sequence ID" value="XM_006695933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCC5"/>
    <dbReference type="STRING" id="759272.G0SCC5"/>
    <dbReference type="GeneID" id="18259711"/>
    <dbReference type="KEGG" id="cthr:CTHT_0056730"/>
    <dbReference type="eggNOG" id="KOG0317">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041707_2_0_1"/>
    <dbReference type="OMA" id="YCDVVQL"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16527">
        <property type="entry name" value="RING-HC_PEX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000395">
        <property type="entry name" value="Putative Peroxisome biosynthesis protein (Peroxin-10)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350:SF0">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="21">
        <location>
            <begin position="377"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EGS19051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="429" mass="47017" checksum="D6DF8D4906E1DDB4" modified="2011-10-19" version="1">MAAQPPKPRPPPPVTTSPYPFAAAPDIIRAHQKDAYFQGVLANQLSDLHRRLRGARAAHSWATETRALADALYLCLTTLIGNRTLGEEYCDLVQVEAPSPKPAPSGSALSLTDSKSPEDDGSGGPLLPSLPRRAGYILTSVLIPYLFNRLLPRARTALRKKLHSRLTTIVRQGRDQTRFGQPSTEYRVLRYLLTHLSSLTNAAHLHAVTLAIFYFTGAYYSLSKRIWGLRYVFTRRIDPNAGGRAGYEVLGVLLVIQMVVRGWLHIKQQILGSGAAQQQSEDDDPDFRERGILAPSAMVDVSLDEHALTSNNSLLSPDATAGGGTSGNQRSLAEIGQTTHTPVPKGNRARFDLSLPPADPEKGLVMGWIKGSAQRMCTLCLEGLRDPAATPCGHVFCWRCIGDWVREKPECPLCRREALAQQILPLRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCE4</accession>
    <name>G0SCE4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0056920</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696015.1">
        <property type="nucleotide sequence ID" value="XM_006695952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCE4"/>
    <dbReference type="STRING" id="759272.G0SCE4"/>
    <dbReference type="GeneID" id="18259730"/>
    <dbReference type="KEGG" id="cthr:CTHT_0056920"/>
    <dbReference type="eggNOG" id="ENOG502SHU8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071111_1_0_1"/>
    <dbReference type="OMA" id="VAMVNHM"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF7">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="69"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS19070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="286" mass="32077" checksum="9DF21B76100071CF" modified="2011-10-19" version="1">MFSRRFDASSFSKSFSKSTRHSRSTSFSVKDAGVSKRRPSESRRRPGTSSGSVADSSDVTLDNVISPIVTLIVGPDQRIFAAHENVLAKSPFFQSILQNQLLEAQTKKILLPDEEPEVFSAVLEYLYKGEYYPRLIFNKKRNTWELEQEADGGRAEATIHHHEVEGELLKDTAIYCAAEKYGLEELKRIALRKQGLQCGIQASTILTSARYAYAHTPDTDSKLRAHYLALIIRSRNTFKRSGTMQLEMFNGGTQLFFDLFVALCNHVDDISAAASSPRSPRSGRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCE7</accession>
    <name>G0SCE7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="12">NAD(P)H-dependent D-xylose reductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0056950</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; D-xylose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696018.1">
        <property type="nucleotide sequence ID" value="XM_006695955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCE7"/>
    <dbReference type="STRING" id="759272.G0SCE7"/>
    <dbReference type="GeneID" id="18259733"/>
    <dbReference type="KEGG" id="cthr:CTHT_0056950"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_0_1"/>
    <dbReference type="OMA" id="DMYLVHT"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="BRENDA" id="1.1.1.307">
        <property type="organism ID" value="1279"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00810"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032866">
        <property type="term" value="F:D-xylose reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042843">
        <property type="term" value="P:D-xylose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd19115">
        <property type="entry name" value="AKR_AKR2D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000007">
        <property type="entry name" value="NAD(P)H-dependent D-xylose reductase xyl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044487">
        <property type="entry name" value="AKR2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="10">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS19073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="325" mass="37017" checksum="299818D144509F8F" modified="2011-10-19" version="1">MAPQIPNIKLSSGYDMPQVGFGLWKVDRSICADVVYNAIKIGYRLFDGACDYGNEVEAGQGIARAIKEGIVKREELFIVSKLWNTFHDGDKVEPIVRKQLADWGIDYFDLYLVHFPVALEYVDPSVRYPPGWFYDGEKEIRPSKATIQETWTAMESLVEKGLARSIGVSNFQAQLLYDLLRYAKIRPATLQIEHHPFLVQQELLNLAKAEGIAVTAYSSFGPQSFLEFNMKHAVQLTPLFEDETIKKIAAKYNRPASQVLLRWATQRGLAIIPKSTRPEIMKSNLESIEFDLSEEDIATISAFDRGLRFNQPTNYFPTEHLWIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCH4</accession>
    <name>G0SCH4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM7</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">MCM7</name>
        <name evidence="15" type="ORF">CTHT_0057240</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696045.1">
        <property type="nucleotide sequence ID" value="XM_006695982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCH4"/>
    <dbReference type="STRING" id="759272.G0SCH4"/>
    <dbReference type="GeneID" id="18259762"/>
    <dbReference type="KEGG" id="cthr:CTHT_0057240"/>
    <dbReference type="eggNOG" id="KOG0482">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000995_7_2_1"/>
    <dbReference type="OMA" id="AQHVTYV"/>
    <dbReference type="OrthoDB" id="3207464at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17758">
        <property type="entry name" value="MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000004">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000288">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008050">
        <property type="entry name" value="MCM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF26">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24901">
        <property type="entry name" value="WHD_MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01663">
        <property type="entry name" value="MCMPROTEIN7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="14">
        <location>
            <begin position="390"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS19100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="836" mass="93015" checksum="A07F614C49F5FA2B" modified="2011-10-19" version="1">MALLQMRAPVDYRAQEDAFEAFLRDFKCTPEQTITTALGNINIADDDLSDDEDLMADDNTPRRPKERSAPTHKYQEILQRLADRKQSEIMIDLDDLYTFEQEVYQNEGLRLVESVENNTKHYVELFSRAVDKLMPQPSEGITFKDDVLDVLMANRRERNELLASAAEREADPTILQDQYPAQLTRRYTLVFKPRSATLDHPPKALSVRQVRGDHLGKLITVRAITTRVSDVKPIVQVSAYTCDRCGCEIFQPVTAKQYGPLTLCPSKDCTENQAKGQLYPSSRASKFLPFQEVKVQELAEQVPVGQIPRTLTVLCYGTLVRQVNPGDIVDISGIFLPTPYTGFKALRAGLLTDTYLEAHYIVQHKKAYDQMEIDPLMARRLTRFAHLGNQYEILARSIAPEIYGHLDVKKALLLLLVGGVTKEVGDGMRIRGDINICLMGDPGVAKSQLLKYISKVAPRGVYTSGRGSSGVGLTAAVMRDPVTDEMVLEGGALVLADNGICCIDEFDKMDDHDRTAIHEVMEQQTISISKAGITTTLNARTSILAAANPVYGRYNPRLSAVENINLPAALLSRFDILFLLLDTPSRDADLQLAKHVAHVHMHMRHPDLNVNGENGSSSEAAIFTPQEVRAYVAHARTFRPVVPPAVSEYMVKTYVRMRSAQRRAEQKARTHPNANLNNFGHTTPRTLLGVVRLAQALARLRFSNTVSQEDVDEALRLLEASKESLLTTVDSDGRKRGSAMNASSRIYNLVKGLADSGACRPDDVSDDDEDEAGSLGVELSLRKVKERVIAKGFTEQQWLAALEEYTELDVWQTAGNGTRLVFITSGNERDASDEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCI0</accession>
    <name>G0SCI0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA mismatch repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0057300</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696051.1">
        <property type="nucleotide sequence ID" value="XM_006695988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCI0"/>
    <dbReference type="STRING" id="759272.G0SCI0"/>
    <dbReference type="GeneID" id="18259768"/>
    <dbReference type="KEGG" id="cthr:CTHT_0057300"/>
    <dbReference type="eggNOG" id="KOG0218">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002472_0_0_1"/>
    <dbReference type="OMA" id="INMHAAR"/>
    <dbReference type="OrthoDB" id="121051at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.110:FF:000008">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000006">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000004">
        <property type="entry name" value="DNA mismatch repair protein Msh3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003810">
        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF122">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="12">
        <location>
            <begin position="990"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="193"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR037677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS19106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1151" mass="126175" checksum="FECBD5EF57EB385A" modified="2011-10-19" version="1">MAGPSKPSEKRQVSLRNFFTPKPRDPPAADGSSTQSLSTSAKPNDDQKKVASPASASSAPAVPKKRSLKAKDEEEEAKDEDDEAETSNRLAKRVRPSRPLRSSRSARAIVDDEDDEDVDQSSPAREKSASPPSLASIPKGSASSRTERFVYDPNRSATGQAGGDDEEDIAAKRRKEELHRKFVKKLGDPDSLPFFRIRDPLPDDTGTPTLDGDDEEGGDEEEPPPPPTTKKGAKSKLTPMEIQFLEIKRKHMDTILIVEVGYKFRFFGEDARIAAKELSIVCIPGKLRYDEHPSEAHLDRFASASIPVHRLNVHVKRLVAAGHKVGIVRQIETAALKKAGDNRNAPFVRKLTNVYTKGTYIDETGELDQPGEATGASAGGYLLCLTESPAKGLGTDEKVDVGLIAVQPATGDIIYDSFEDGFMRREIETRLLHISPCEFLIVGELSKATDKLIQHLSGSSTNVFGDKSRVERVPKGNTMAAEAYSHVTQFYASKTNEKDPKSAALLEKVLKLPESVTICLSAMITHLTEYGLEHIFALTKYFQSFSTRQHMLLNGTTLESLEVYRNATDHSEKGSLLWALDKTQTRPGRRLLRKWIGRPLLDHEQLQERVEAVEELLENQNTYKVDKLTNMLSNIKADLERSLIRIYYGKATRPELLSTLQALQRISIEYSTLKTPADTGFKSRLIAEAIMSLPAIGNIVTSYLDKINAQAARKDDKYAFFLEEYETDDITKHKLGIAAVEADLDLHRKDAAAKLGKKTPVNYVTVAGIEYLIEVPNTDLKYVPASWVKISGTKKLSRFHTPEVIRLMNERDQHKEALAAACDAAFSNLLKSLAAEYQPLRDAVASLATIDCLLSLSQVASLPGYTKPTFLPPGTPPTITITQGRHPIAEHTLPDGYIPFTTSLTSPAPIAQLITGPNMGGKSSYVRAVALLVLLAQIGSFVPADAMSLTLTDAIYTRMGARDNLFAGESTFMVEVSETATILRSATPRSLVILDELGRGTSTHDGAAIAHAVLDHVVRETKCLTLFITHYQSLARVAAGLGDGLIKCVHMRFSATTNEEGEEEITFLYEVADGVAHRSYGLNVARLARIPRKVLDVAAQKSREMEDGMKVKRLRGAARLLGDVLSSPGGEDGDAAVADQLNHLISSIEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCQ5</accession>
    <name>G0SCQ5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0058060</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696126.1">
        <property type="nucleotide sequence ID" value="XM_006696063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCQ5"/>
    <dbReference type="STRING" id="759272.G0SCQ5"/>
    <dbReference type="GeneID" id="18259844"/>
    <dbReference type="KEGG" id="cthr:CTHT_0058060"/>
    <dbReference type="eggNOG" id="KOG0070">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040729_9_3_1"/>
    <dbReference type="OMA" id="KEIRILX"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04150">
        <property type="entry name" value="Arf1_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000024">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045872">
        <property type="entry name" value="Arf1-5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU369003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS19181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="185" mass="21140" checksum="D9673DFBE5EDEB7C" modified="2011-10-19" version="1">MGLAGSKLFSFLSLLMKQKEMRILMVGLDAAGKTTILYKLKLGEVVTTIPTIGFNVETVEYRNIQFTVWDVGGQDKIRPLWRHYFQNTQGIIFVVDSNDRDRVPEAREELQRMLNEDELRDALLLVFANKQDLPNAMTVAEITDKLGLHSLRQRKWYIQSTCATTGDGLFEGLDWLAQEIKKSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCW0</accession>
    <name>G0SCW0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein CFT1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cleavage factor two protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Protein cft1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0058560</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CFT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696176.1">
        <property type="nucleotide sequence ID" value="XM_006696113.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0SCW0"/>
    <dbReference type="GeneID" id="18259894"/>
    <dbReference type="KEGG" id="cthr:CTHT_0058560"/>
    <dbReference type="eggNOG" id="KOG1896">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002414_2_1_1"/>
    <dbReference type="OMA" id="PMTKFKL"/>
    <dbReference type="OrthoDB" id="6109at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000788">
        <property type="entry name" value="mRNA cleavage and polyadenylation factor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="11">
        <location>
            <begin position="94"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="12">
        <location>
            <begin position="584"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="10">
        <location>
            <begin position="1061"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="468"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1297"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="480"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1298"/>
            <end position="1331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS19231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1460" mass="158819" checksum="FA4319FECA999CE3" modified="2011-10-19" version="1">MQCYTELTPPTGVTHSITLQLIPGQGTNLVVAKSSLLQVFRTKTVTTEIDTLQTNGASKGRSAARYENRLANDDDGLEASFLGGDSLGFRADRTTNTKLVLVYETPLAGTVIGLSKIKTSTSRSGCESLLLAFRDAKLSLVEWDAERNALGTVSIHYYEQEELQGSPWAAPLSHYVNFLVADPGSRCAALKFAARNLAILPFRQVDEDIDMGDWDEELDGPRPQKDVSNAAVSNGASNIEDTPYSPSFVLRLSNLDPSLLHPVHLAFLHEYREPTFGILASTSSASNALGRKDHYTYMVFTLDLQQKASTTILSVSGLPQDLYRVVPLPAPVGGALLVGCNELIHIDQSGKPNGVAVNPMTKQCTSFGLADQSDLNIRLEGCIIDVLTPDLGEFLMILNDGRMVLITFRIDGRTVSGLELRLVPPASGGTIIPGRISTLSRIGKNVMFAGSEEGDSLVFGWTKKQTQAGRRKSKPRDDDFYMDDYEEEEEEVDEDDLYGEETTSHHQPVSAASSLLSGDLSFRIHDRLISIAPIQSMTYGQPVWMPGSEEERNSIGVHADLQLVCAVGRDKSSCLATMNLAIQPKVIGQFEFSEARGFWTMCAKKPIPKSLQSDKGVSVLGGNDYDTGGQYDRFMIVAKVDLDGYEKSDVYALTAAGFEGLCGTEFDPAAGITIEAGTMGKGSRIVQILKSEVRSYDGDFGLSQIVPMMDEETGAEPRAVTASIADPYLLIIRDDSSAFIAGIDSSNELEELRKEDKVLVSSKWLSGCLYNDSTAIFAEETAKSSKPTQSILLFLLSSSGALYIYRLPDLSKPIYVTDGLAYIPPALSSDFTVRKGTPKEAITEIMVADLGDTTHKSPYLILRHSNDDLTIYQPYRYKLGTGQVFSKTLFFQKLPNPSFARAPEETEQDDVPPQPRLLSMRRCNNIAGYSTVFLPGHSPSFILKSAKSMPRVVPLQGAGVIAMSPFHTEGCDHGFIYADSHNIARVTQIPEDWSYAELGLAVKKVPIGEDIAAVAYHPPQQCYVVGCNASEPFELPKDDDYHKEWARENLVFKPTLDRGLLKLISPITWTVIDTVQLEPCETVLCVETLNLEVSESTNERRQLIAVGTALTKGEDLPTRGRVHVYDIADVIPEPGKPETSKKLKLIAKEDIPRGAVTALSEIGTQGLMLVAQGQKCMVRGLKEDGTLLPVAFMDMSCYVTAAKELPGTGLCLMADAFKGVWFVGYTEEPYKMMLFGKSSTKLEVLTADFLPDGKELFIVACDADGHIHILQFDPEHPKSLQGHLLLHRTSFNTGAHNPTKSLLLPSTLPTDTPSTIDGSNPNTNNTNGTPNASNLAPYDATERPHILLLCSPTGLIAALRPLSESSYRRLSSLAAQLVNSLPHAAGLNPKGYRMPSADCPPAGVDASVGRNIVDGTVLERFTELGMARRAELAGRAGYAGIGEVRAELEGVLGWAGLGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0SD16</accession>
    <name>G0SD16_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0050430</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695391.1">
        <property type="nucleotide sequence ID" value="XM_006695328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SD16"/>
    <dbReference type="STRING" id="759272.G0SD16"/>
    <dbReference type="GeneID" id="18259081"/>
    <dbReference type="KEGG" id="cthr:CTHT_0050430"/>
    <dbReference type="eggNOG" id="KOG2204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003818_0_0_1"/>
    <dbReference type="OMA" id="TGMMPER"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000037">
        <property type="entry name" value="alpha-1,2-Mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF29">
        <property type="entry name" value="ALPHA-1,2-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="451"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="539"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="357"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS18446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="563" mass="63780" checksum="8E9AE46644A57B8B" modified="2011-10-19" version="1">MNDGPPTYPYTFVKSSVDWGQIPHRYLTPRDLIQLPTRCHVSPLPRVQHRFKPESREVRRARDARRRAVRELTRKCWESYREYAWKQDALMPLSATGRDQFSGWAATLVDSLDTLWIMGFREEFDEAVAAVAEIDFGVSTTSDQVNIFETNIRYLGGLLAAYDLSGREVLLQKAIELGNLIYAGFNTENRMPVDNINLTAAKEGTGLFVEDQVVSASPGTLTMELAHLSQLTGDPKYYDAINRVVDLFFRNQNRTALPGLFPQYVSMSREDVTTGASFTLGGGADSLYEYFPKMYALLGGLESKYATLTLGFMDAAKRHLFFRPMVPDNADILMSGNVFIDKEGSPRLDPEIEHLACFAGATFALAGRLLGNEENVDIGARLARGCAYAYRAFPMSIMPERLNMVACEPGRPCRWDEEKWRIEKEKRPEYKPHLPKGFTSVKDPRYILRPEAIESVFYMWRITGDPEWEQTAWEMFLAVANGTATQLGSASVKDVTVARSQVQHDDYMESFWIAETLKYFYLVFSPPDVISLDEYVLNTEAHPFRLPGVSQEAATRAPWYPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDE3</accession>
    <name>G0SDE3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HTH APSES-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0051480</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EFG1/PHD1/stuA family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695489.1">
        <property type="nucleotide sequence ID" value="XM_006695426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDE3"/>
    <dbReference type="STRING" id="759272.G0SDE3"/>
    <dbReference type="GeneID" id="18259186"/>
    <dbReference type="KEGG" id="cthr:CTHT_0051480"/>
    <dbReference type="eggNOG" id="ENOG502QW2C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016460_0_0_1"/>
    <dbReference type="OMA" id="HEAEYTH"/>
    <dbReference type="OrthoDB" id="5407653at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.10:FF:000003">
        <property type="entry name" value="Ascospore maturation 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029790">
        <property type="entry name" value="EFG1/Phd1/StuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47792">
        <property type="entry name" value="PROTEIN SOK2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47792:SF1">
        <property type="entry name" value="PROTEIN SOK2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0183">Conidiation</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="10">
        <location>
            <begin position="115"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="235"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="243"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="300"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="331"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="346"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="369"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="418"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="431"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="447"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="497"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="542"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="591"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS18544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="611" mass="64853" checksum="B722092CA7F56B34" modified="2011-10-19" version="1">MNGPQMYYQSHLSGGQAPPPPPPQPVTPHYAPPPQQPPLAQPAPIQYGPAPPPGYGSHYGYANGLSSPAGPTSTMPPPMTSPLPLPPVSQPALPPTYSPGFDTTGQIPPPGMKPRVTATLWEDEGSLCFQVEARGICVARREDNHMINGTKLLNVAGMTRGRRDGILKSEKIRHVVKIGPMHLKGVWIPFERALDFANKEKITELLYPLFVHNIGALLCHPSNSARTSQVMAAAARSRAEPRIPAPLPPLHHPLALPAPPQAPPPVSQPPPVTSRPGAVDQRTPSFSAPSTTTSGVIGTASDNYQWSQQNLSNGQPTSQITTVDSNGRSLPGTPTTTPPGSTMPSIQSSYPPVTQSYDSSRSVYPVPSAQASTYPTSTSAPDRPLYSHSSYIKTEIAAPSSRPAGSEPIDQKPPNGIQGEVVQSGVVEELPSDHEEGGEYTHDSGAYDTNRSSYNYTAPPVTSLPGEHSHISSDLSGSPHQGSGRATPRSAAAPQTYYGQQSYNSPPRAGQTSSSLYSVMSNERGAPTTNGTSSGDAYGTQGDVTSSMQNGYAPQSMLNGSAGVKRGRDDDDDRDMKRRKTFDGNPLPSPAYSNPMTRTQPRAIAATQQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDV7</accession>
    <name>G0SDV7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0053150</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695653.1">
        <property type="nucleotide sequence ID" value="XM_006695590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDV7"/>
    <dbReference type="STRING" id="759272.G0SDV7"/>
    <dbReference type="GeneID" id="18259353"/>
    <dbReference type="KEGG" id="cthr:CTHT_0053150"/>
    <dbReference type="eggNOG" id="KOG2345">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_109_1_1"/>
    <dbReference type="OMA" id="AMHQYKV"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13986">
        <property type="entry name" value="STKc_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000550">
        <property type="entry name" value="Serine/threonine kinase 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000374">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052239">
        <property type="entry name" value="Ser/Thr-specific_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45998">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45998:SF2">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409086" description="non-specific serine/threonine protein kinase" evidence="12">
        <location>
            <begin position="18"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="32"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="165"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="349"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS18708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="421" mass="45799" checksum="806E305CBE80449E" modified="2011-10-19" version="1">MAQVVLDLLSSLSGCLSCFPSSPTLKVNSRSLKILRLLGEGGFSYVYLVQDTSSSELFALKKIRCPFGAESVAQAMREVEAYKLFAHSKGIIHAVDYAIATERGGGEESKTVYVLLPYYRRGNLQDMINANLVNHTRFPEKRLMCLFLGVCKALRDMHQYRGPGLGGQGATGGQAERMEVPSRGKGKGKGKGKGGQSAGREDEEEDENEQQKPLMTEDERMPAPAPGQVRSYAHRDIKPANIMISDSGTDPIIMDLGSIAESPLPITSRSLAIATQDIAAEHSTMPYRAPELFDVKTGSVIDTKVDIWSLGCTLYACLVGKSPFEMRSDETGGSLSMCVMSGDWRFPDEGPGAAGGKGKGKQIGGGQGQGANGRAEEYRISEPIREVVRRCLRVEPSERPDIDELIEMVEKVVEELPDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDX1</accession>
    <name>G0SDX1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative UPF0507 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0053300</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0507 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695667.1">
        <property type="nucleotide sequence ID" value="XM_006695604.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0SDX1"/>
    <dbReference type="GeneID" id="18259368"/>
    <dbReference type="KEGG" id="cthr:CTHT_0053300"/>
    <dbReference type="eggNOG" id="ENOG502R3ZQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002294_0_0_1"/>
    <dbReference type="OMA" id="HFPMIAR"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097422">
        <property type="term" value="C:tubular endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000443">
        <property type="entry name" value="Putative vps9 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051248">
        <property type="entry name" value="UPF0507/Ank_repeat_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24170">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24170:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G09870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="4">
        <location>
            <begin position="373"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="70"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="177"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="245"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="560"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="611"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1242"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1284"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1359"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="561"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="579"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="627"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1242"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1288"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1313"/>
            <end position="1322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS18722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1446" mass="159125" checksum="3ED4DE83E53C5631" modified="2011-10-19" version="1">MQPLNPFLSAFSKSSALLAQCQPPQHHVLLVPTADVLLNSRDPDSGAPLVASIVENDFLASHILRIVPPKGGGQQQAGGGGGGKDDAAAAQGGQQQNLREMRGKPRLYATINGRSLVIKDSTVFTNKGFKNLAQATLLHDVIWYPDTLDPRPFLVYYISRPLVGTWVEVKIPPAILPPPSSKGIAEPARLPAKPPGNRQQSNPPKKKDVKSFHELLNHFPAIAKQMQSGLEKLFREFTLVFERPLPPPPSAPEIPDPEPDGPISRAVKRARSLSDARYDPSKAAAVSPSSDLDDPPIPIPDKPPEDDETVMRTALETAVMAAIDLFQSVDRNQLAHLGQTTDLTGPVVERLIERYIAENVHHFLFPRLAALRRQEDLELEAKIRQMDHIDIAQLGVVIEGGSRAKRAAVSRLQRAVEEFRRLPNASCPQEMMEILLATVKAATQLTDVPPQPPSDVQQGPTSSEKPVMTINADTLVSLLLYIVIKAQVKHLQARLAYIRNFIFIDDIESGEMGYALSTFEAVLSYLDRESGGLRRASRRNKALWDATARGDLKELRRIMEPNDDVVDDGDGDEDKGWGSESTEVNRSSASLTLSERFSLGSGLGHVFPFVENGMTEESGGDGDGETQQQQQQQQQQQQQQQQQQQQQPMKRPKKVVMDTRSMSSGSEISFRSMPLSVGTFSGMEGDTSIERLSQTHDAFGESVPMMAIQNRQPEALRYLLSLSQYYSAEAILEDRNNEGTTLFSAAVQLGDETIVETILDFLLARVDDDKLREYFAIQDTWGRSAAHYLFHAPFLIRRIGHMLPWRQKDRNGQTPLFALCRSYDHPNYSTMVEEALEAATKTQGDGQPLHLDHHVDIKGNTLLHIINDAALAARILQQCDVDVNAVNEKKFTALMLAAKYGRFDMVRVLFSDPRVDTAARELRGLTAVELAKDDDLRNKMDDLTLFMLTPPPIPPPTAAMATAGDKRTADELASRTTGVVRAFFVEDATVRFVVKSGAPLDSNSYAVTTCRRSLGDFEHLARLLQMENPASWIPSLADLRSPVQIPSRPSRAVLRDLQVRMDWFLRVLLAHPTFATHEMLWEFFLVPDLQLDMMAERSRLKYEALMEKVHEELEPVEDLREVEQFVDHARDMVRSVQFGTRSVARRANAVVNAASDLHESAALLSQSLSTLPFLPSSHAAAFATYVRTLCPSQSSPYQTFFSSFLALHANIEAILKALARPPQTIARIAAIRRDAERASARSSTASLIAGGGSSSPTPSTGEGSRSRWPSLVTSLFDGVSLTAVAGTSSSSSPSSPNPNSNDPNLGPTTRQSRAAARAARSLNEAERLARELRYAQQTVAGELAGWREMHERMGRRAIRELARGVLREERERLRGLERALRAVREGLVFPGIGGREGEFGMEGVGVGVGVGMDGGEGAGWLGAKTPSAEQLTLTAGKRWDGLNLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEB4</accession>
    <name>G0SEB4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0063150</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696622.1">
        <property type="nucleotide sequence ID" value="XM_006696559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEB4"/>
    <dbReference type="STRING" id="759272.G0SEB4"/>
    <dbReference type="GeneID" id="18260353"/>
    <dbReference type="KEGG" id="cthr:CTHT_0063150"/>
    <dbReference type="eggNOG" id="KOG3133">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043063_1_1_1"/>
    <dbReference type="OMA" id="YEPMREM"/>
    <dbReference type="OrthoDB" id="21292at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033328">
        <property type="term" value="F:peroxisome membrane targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.900">
        <property type="entry name" value="Pex19, mPTS binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006708">
        <property type="entry name" value="Pex19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038322">
        <property type="entry name" value="Pex19_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774:SF2">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04614">
        <property type="entry name" value="Pex19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="361" mass="38684" checksum="8EB343C45C648710" modified="2011-10-19" version="1">MASNTDGVGAAGAHKNLAETPTVPSSKAEEKKPVTVEAVVDDGDIPDPDEDDLDDLDGEFSYAPMPISAAAAASTTAAGPSSQQAPGAGAEEPVLSEEEFARQLQAGMAELLGELERSVWRTNSAPTQALDLTQPQPEVQAQFESIFRELGAAASASAEEIAKNPPPGAAPVAGSSGSRPSTSSGPSPADAASFQETIRKTIERMQQSGEQATAAAAAEGADDFLTELLKQMQSGALDGEGGEEEFSKMLLGMMEQLTNKEILYEPMKELHEKFPEWIEKNRGKVSAEDLQRYEEQQTYVREIVAKFEEPTYSDENKADREYIIDRMQKMQATGQPPADLVGEMPSTQDILNMPDESCNPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEH2</accession>
    <name>G0SEH2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0063740</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696680.1">
        <property type="nucleotide sequence ID" value="XM_006696617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEH2"/>
    <dbReference type="GeneID" id="18260412"/>
    <dbReference type="KEGG" id="cthr:CTHT_0063740"/>
    <dbReference type="eggNOG" id="KOG4300">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037990_6_0_1"/>
    <dbReference type="OMA" id="GPWEKID"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052356">
        <property type="entry name" value="Thiol_S-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036:SF1">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="296" mass="33156" checksum="DE9CC88435FF5621" modified="2011-10-19" version="1">MLPPVLASLIDPWMFMGLALSYLPGTILRLVVARDFRTLFSWSRFQAAWFAAFWSRVGPEVRLNATKNVLPLLQGRVTAGVVPPEDSVPSSNPNDNPHPPIHGTLLELGPGSGMWVSLFSATSQRENRLGPIAKIYGVEPNTDVHPLLKTQVREAGLDKPSGGQTHYEIVPVGVESLAESGKVKPNSVDCIVTIMCLCSIPEPRKNMALLYNYLKPGGRWYVYEHVKCFQHQPWGMRVYQSFLNFLWPHIVGGCQMCRETGKWLREAGPWSQVDVHPLADEPWYYTMPHVIGVLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0SF77</accession>
    <name>G0SF77_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1765-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0061080</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696424.1">
        <property type="nucleotide sequence ID" value="XM_006696361.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0SF77"/>
    <dbReference type="GeneID" id="18260146"/>
    <dbReference type="KEGG" id="cthr:CTHT_0061080"/>
    <dbReference type="eggNOG" id="ENOG502R8B9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003877_0_0_1"/>
    <dbReference type="OMA" id="KTCAYAF"/>
    <dbReference type="OrthoDB" id="296767at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013887">
        <property type="entry name" value="UPF0592"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37988">
        <property type="entry name" value="UPF0592 MEMBRANE PROTEIN C7D4.03C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37988:SF1">
        <property type="entry name" value="UPF0592 MEMBRANE PROTEIN C7D4.03C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08578">
        <property type="entry name" value="DUF1765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1098"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1157"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1299"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="374"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1157"/>
            <end position="1174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1470" mass="159715" checksum="C6F93AF7FA0A419C" modified="2011-10-19" version="1">MPMSHAMSPMSHAMSHAMTGPTLTVPARAADTTSATATVVTHVRSSFINNPSSSAPGLLSVGGATPNASTSSAAAATATAATRSSASSALTSIPALSAIEIPSFDLLSEFDKSFFSFSTSPSADTTTSATLANTSTSTPPSQSTLDVPPPPPPKPTPTIATSPCATKVTSGAPPQTLAQRPATAVPDQKFGAQLERSKTDSDAKRAANCPAATALPQHRQPETVPIGLKPAVNPSPSTANSMVDRPISWLPSSKASSSAKPTAQEASRVKRLFRQNAVSREEKAEKPVESSSKPAESSASPTKKSWLSRARLPPPATSTPNSSYSSLEKSEPLKTKTESKSLTSNLASALLSKLRQKPQTVFSKGSDPSSKAISRTSRLIIPISSTSSSPATTTSSSPTATRNASPNGFGAGNTRTPFQRASSVDTDLDTDSATACSASENASRSSRSTADTTVTVPSRDPLWSTFRMIDLEFARFAAKSTTSLRMGVVRSMLLPFLRSTAYHPSNADLSILNAEDVDRRAAILNRWWNALLAMLAGNNSKLPPGLAPNVDALGVPFPVLQPVAGVDRPTLLEAICMIMMRPEWRACTSYWQPLASRCPDERVRARSATQSSSDSDVDSILMAESAEHNIRTMFIANLTTQMALVVEKLALKHAPLSLINWCGRACAYAFFFVPGVADVLVRLWGINADVLRRVADEFGLPRRNKGESEDIVALFPPHLHKLGWSSVKTLADRLRVAAKLPLPLAKIQWHGPWVSRWRGADTDLFYVFCKHFYLLGQDFMLKGLPLVEKARSPAFVLVHAQLLSILDSAIHGQLSSDPMLGPPISEGAHGADAALLPAPELPSNVVAGMSEHRLIIMLKHMLRGEQDTSDVPAEIKHTFAEAFVAITKAATKRTPKFEHAACFVLCDLLEQALITLHAFQTTVNNNAIKFIDWPFWFDVAKMIMDSNNTMSEIRILSFLFAVWDALAADPARKEKLCLEWLLTEDVFAKFFNHWCPMVRAYYMRLLCWRICRDNGKVNELDTKIYLVASQRLKTVWSHYLWLKQDAEMTGKMQPSTAPCYPAPGKRFVIMRLPQQQQHPMRVGFDSFSNSLVGTDPLADLEPISPTGSDRLAAGNGQAEGSSSFKKRWSLLGKVIPFNSTSESQAWEDHRAFREGLQQAQRDSDAARLAARGGAPPVPPKHSPVIRNSTESFCSASSTMTYDTTTDVFRFILTLFELQPGVWVPFPPTRDRILTRPRLPGPAQARVTARLTGISANMNMPTNYTDLFLFQSDTPPLISPGLPPETRRVSGQLHTGLISEARNARPLTDDEDDGRRGRRISFSATRAPPSREYQDNVRSLSLNRTVPHIRFGGDAVGASPRRLSLDADPTRPPNRRRTSCSSDSEYGYGHMSGWPPQQQQAPAPPAVRAEKPTGPYAQGAVYCGRALAEWAVVVTECNSFIERRRDEGILGLADVEVPVLGVEGLGFQRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFJ9</accession>
    <name>G0SFJ9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytoplasmic tRNA 2-thiolation protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">NCS2</name>
        <name evidence="3" type="synonym">CTU2</name>
        <name evidence="5" type="ORF">CTHT_0071100</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTU2/NCS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697382.1">
        <property type="nucleotide sequence ID" value="XM_006697319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFJ9"/>
    <dbReference type="STRING" id="759272.G0SFJ9"/>
    <dbReference type="GeneID" id="18261148"/>
    <dbReference type="KEGG" id="cthr:CTHT_0071100"/>
    <dbReference type="eggNOG" id="KOG2594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024534_3_0_1"/>
    <dbReference type="OMA" id="EGDSTWA"/>
    <dbReference type="OrthoDB" id="25129at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03054">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019407">
        <property type="entry name" value="CTU2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882:SF14">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10288">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="225"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS17764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="406" mass="44750" checksum="ABB38FDB05E5C8C4" modified="2011-10-19" version="1">MAAPPPSTDATSSSPKPCAKCKSSPSTLESRSKPVCQDCFQKFISNKLIRHITLLGKQIPPYPTRRYALGLSFGVSSSVLLSLLAENVEHNIRQGRKLPFELVVVHVAQSLPGEKAEETEKAVEEILQSYREKYPRFEFIISHITLPSPNGEETSSINFATLSPASREDLLRILTRQALIRAAKEKECRVLLVGHSTTAIAEMTLAEAAKGRGRGVSWLVRDGEAYEEGDEEEEGESQPDGDGTKRTVTKKKLLIHHPLRETLRHELSTYARLFSVHVGDRSFIPIDPSKSQTKQPAVVSHRSLSIEDVMTRYFADVELQYPSIVANVARTTGKLLRAGEESFTPAATTQSQSDGKGKSLEKCRICRMVLDEEGDERWNGEVGSIEGEDGVGRKGLCYGCRSALLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFW6</accession>
    <name>G0SFW6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0072390</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697499.1">
        <property type="nucleotide sequence ID" value="XM_006697436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFW6"/>
    <dbReference type="GeneID" id="18261277"/>
    <dbReference type="KEGG" id="cthr:CTHT_0072390"/>
    <dbReference type="eggNOG" id="ENOG502SF2G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096170_0_0_1"/>
    <dbReference type="OMA" id="HPIARNK"/>
    <dbReference type="OrthoDB" id="5388322at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027911">
        <property type="entry name" value="DUF4604"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15377">
        <property type="entry name" value="DUF4604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4604" evidence="2">
        <location>
            <begin position="7"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="198" mass="21131" checksum="D0DA8FCCDD336736" modified="2011-10-19" version="1">MSNFNAKNLQYHSAPPPFLARLKGEASCIYDPSRPDPILVSNRRAAKPRSASEEAEDLPVVVDERGEVVEGVVVGKDGDFKGMKGEDKGEVDMKSRERVEGQGEGEGNMGEKKGVVASIGAGRAGKKRKARVVGGGVDDEGDKDDKRGDGDNKKREVKTGKTSEKADEEGAKSEVGTAKPAKMKKAKKIKLSFGEDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFY5</accession>
    <name>G0SFY5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0072590</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697518.1">
        <property type="nucleotide sequence ID" value="XM_006697455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFY5"/>
    <dbReference type="STRING" id="759272.G0SFY5"/>
    <dbReference type="GeneID" id="18261297"/>
    <dbReference type="KEGG" id="cthr:CTHT_0072590"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_3_2_1"/>
    <dbReference type="OMA" id="WGLTLNW"/>
    <dbReference type="OrthoDB" id="47494at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178:SF1">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178">
        <property type="entry name" value="MONOOXYGENASE, FAD-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="9"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS17900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="437" mass="48513" checksum="13C1CBFE9754F3D5" modified="2011-10-19" version="1">MPLPATQKPILIIGAGISGLLLAQHLRKLGGPDKIPFRIFERDADLTTRGLGWGLTLHWSLPALRALLPEELLARLPEAYVDQKAVEEGRASRFPFFDLSTGELKASTPDLPESARIRVTRDRFRRLLATGLEIEWGKALISFQTLEDGSVQVQFNDGTTVEGRLLVACDGGSSRVRNALFPGVPKYQVPVRMMGVRIDCDPEEIDPIRKLDAFFLQGAASQNDSFVYCSILDAPGNINNTTGKYTCQICVSWPIRPGFFGSSEPIDFPTTSREGVALIKKFANTWAEPFRSLAQRIPDETEVKCLQLADWPPPRGLRTQGSVALVGDAMHPMVMYRGEGANHAIIDVHDFVELVLPILLPGPSSSTGIQNPALTLREALNQYEDRVIARTRPAVLASRQACLDAHEWSRIDEKSPLLTKRDMWVKFDEESMMLRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0SG08</accession>
    <name>G0SG08_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0064610</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696765.1">
        <property type="nucleotide sequence ID" value="XM_006696702.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0SG08"/>
    <dbReference type="GeneID" id="18260499"/>
    <dbReference type="KEGG" id="cthr:CTHT_0064610"/>
    <dbReference type="eggNOG" id="KOG2710">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_251520_0_0_1"/>
    <dbReference type="OrthoDB" id="524326at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="305"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1416"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1447" mass="159798" checksum="E95C9D1C19A30319" modified="2011-10-19" version="1">MSINLVLDDDLRDQLVAWNRWGAVAGGPQSSSSSRDSVVELCRHASALKTQHAHDSQRSSVQTVKYVGRDEGIHEFTSNIHHTSTQNHDAGSSADRPDPRISTVASDPTLTLQDPAKLSPPLLASASPQSATTITFCRISRFPCAHPCDVPDLVCESDTTLSLSTCSEDPGTPNLDDLFLPLTQLSLPDLHLGAFEPISMVPAGDEDIDDGASMTPTEISFAESSEGVRLPTAESAPQSIKSLENGSQTSGPVKLFRLRTSAQKSSEMPLPLPSEPNRISKLLRMPWVPDDKAPTVFGVDLKESVRLAPMKIRILHKGRSTSYRTYPTCVYKCCEFIRANAHRDVFLSPGDPANIAALKALFNQAPSYGLHFRFEDYDYTVHDAARLVLLFLEELPKPLIPASVFKSWILLGKQYGAIEPSCPRVETGLDFWTEALNRLSTPARNLTKLLLTLFAEVLLDAHGTIHEAHARQLASAVSRALFHQEMHTAEENRIKGRRRHTTSTKRNVQPTLALAFLIQKRGEYVSSLRGLTSGKGDSELFLPSTKEIMEWRGKSENKESGKVSETSNKMPTGCKCGSQSDISGVEDDPNPVAMVAGRPVPGPAGTDIRPNPFLRDFPGNASPWLAEASGHGDFLEYHCNIYIVHWSKRGRWEVVLVEDRLSSLYLLAQAGEVGVKLIKDQGNEVEWAEFEQAICWAIAANIDGVLQRAVRHRYQVVCVQEPPVLFGRVRRHPGFTLYAIDDRATRAAIYVDRRLLVSAPTAPEHGLVTVSLQGITIVNIDPNSFIVVGDFNAHHPDWDPRACPNPKGDMVRTWIATRGLHILNPEGPTHRGGGVIDLALGPARAFAEFAHWASDHRALLVSIPSRSPSRLPPPKRLPKARFEEVAHLLKSLLPPAPVTFDSREELEQFAWDVAPWWSEVLATAREIDPIVYHKLCKEAKVNFYREKVSSASTPAEWGKILRWRFDHSDDRPTVLVVDGRVISDTERMAAYLATQAFRPAGAQEGPRPVWLGPRLPPEWAARLADPSSDDELRDAFLGATSNTPGLDGVPLAFLRHAWELATVVTLSKPGRDPRSYKGWRPITLLSTFGKGVERLLARRMTAAALNSGLLPPDVAGAVPSRSALDLVQALVHDAETMSRQGYHGLLVTLDVDSAYPFVQPPILREGSSFMYMDDHAQLSWSKHPIQLAHHASLRVSQLCAKARELGLRIDPSKTEVLYIPPRGARAKRSRIDPARISTQVEGVSLSPRKSIKWLGVSLNPKLSPVTHAAARASATASVGCKRGSESDFPGVENDTDPVALVAGWFYPEHLLDRERARWRSRVEMLPANHPLHAASGLGARPQWEPKRLGVRVWLGLPLDAPKRRRVPPPDMRGWWRANKPASALWDGHTAKPFLERFSRQCLSRWPAEASGHGNFSEYHSHRGIDPDTDSSESVSELEIHIPGFVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0SG19</accession>
    <name>G0SG19_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16 17">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="6 16 17">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CTHT_0064720</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16 17">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 16 17">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 16 17">Belongs to the CDS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6 16 17"/>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696776.1">
        <property type="nucleotide sequence ID" value="XM_006696713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SG19"/>
    <dbReference type="STRING" id="759272.G0SG19"/>
    <dbReference type="GeneID" id="18260510"/>
    <dbReference type="KEGG" id="cthr:CTHT_0064720"/>
    <dbReference type="eggNOG" id="KOG1440">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023471_1_1_1"/>
    <dbReference type="OMA" id="FFAYMYF"/>
    <dbReference type="OrthoDB" id="10260889at2759"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016720">
        <property type="entry name" value="PC_Trfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773:SF8">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, PHOTORECEPTOR-SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01148">
        <property type="entry name" value="CTP_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018269">
        <property type="entry name" value="PC_trans_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 16 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14 16" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15 16" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR018269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGS17158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="442" mass="49851" checksum="1A7AD7A2F8A6F4D0" modified="2011-10-19" version="1">MTGRLRRGVKFPYKHNGQSEARRGSFSEASEEGSSRADAIESLDELSKPAKVEDPKTEYEKKKANFITRTFWTFIMIGGFFAALFMGHVYVLAIITAVQIVSFKEVISISNLSSKARDLRSTKSLNWYWLATTMYFLYGESVIYYLKHIVLPYSTDSPGFVFFVGSLKAGHLKFQFSQFAWTHMALFLIVVQAHFIMNNVLEGLIWFFLPAALVITNDIFAYICGITFGRTQLIKLSPKKTVEGFVGAWIMTILFGIVLTNLLLRSKYFICPATNLGANIFTGLECEPNPVFIPRTYTTPELFFLPPNYSISVTIAPMQFHAFFWASFASLIAPFGGFFASGLKRTFKIKDFGDSIPGHGGMTDRMDCQFIMGLFAYIYYHTFIAFKRSSVSHVMELAIMELTADEQMEVIKGVLKYLSNQGIVKSDTPAAFEKLLSSAKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0SG47</accession>
    <name>G0SG47_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sec39 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0065010</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696804.1">
        <property type="nucleotide sequence ID" value="XM_006696741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SG47"/>
    <dbReference type="GeneID" id="18260539"/>
    <dbReference type="KEGG" id="cthr:CTHT_0065010"/>
    <dbReference type="eggNOG" id="ENOG502R87S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006056_0_0_1"/>
    <dbReference type="OMA" id="GMKRAYD"/>
    <dbReference type="OrthoDB" id="3434013at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013244">
        <property type="entry name" value="Sec39_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40787:SF3">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40787">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08314">
        <property type="entry name" value="Sec39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec39" evidence="6">
        <location>
            <begin position="10"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Sec39" evidence="6">
        <location>
            <begin position="114"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="698"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="784"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="726"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS17186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="872" mass="95624" checksum="576FEF0030BB9A50" modified="2011-10-19" version="1">MVNLSPAKLVLLAAHYAVEANIPGLTVLATRHGNVLRSDLLLRILLTYLPETLPSSKYVDLIRQIETRSFPDLSDDVVDPSPVEGFTEQEAKKRVRKLKLLPLTAPEGLEEAGLDYEVAASLLLSQTGVREGDLHLVGRDLRGLISPWLFDERRWRKAGSNQESTELCPGWGEVLHWLTIQASKDWKVAVSAFQRWDGPRDADLAGWGSPQLTDDQRAYLEEGYARAALASAYLIPEATLEALDGAYILLSRAATLHNLEPVPPLSSAVSLLPPLTEQIPNELMSARNLLYSRNDLLSTSNPLTAPTDGSVALLQALVLSAHLLSKAGCPCTVRRAAELALLQDEREQKKGVLSLIRAISMNGPKSDDRYWIKARNEMLWLRDWGAEDGWGAAETAPRGVFGQVKKEFLEVEFLKALLASTRYNLACNIYEESPDRPLDEKTLHDTIYATAMAAYDNSSNPNRHRGGLKKCDEIIKSFPKTFPPSSLSAKKVEALLQATHSLSDYRLVLKQGEPFTPVVLRVHTDPIFIIAKILEQNPKSYTQLHTLLDLGNRMVEAGLTAPKTPSPSQPIPDEASQRALTERRIISLCIDAALSEDDFETAYSYVINRLSTPPLVQIEDNYSWKAALEAGKYRRTSRTTLPTHLGMSSSANVAVRHLEQRIDCLATALRIAPAATLQEILSAFRLAEEELDALVKEEQAKEEEWDAKGDAFRSRSATKYKPPPSASSTRSAQLSNTARHRSTDDDDSTAPMSLFDLSRASMLSAQRNLSALSGLQRAATSLAGTLTSSGRNSPAPARDTDSPRGSLDVGAAMQKQMSNASATSGGSESGGGQQQKRVRKRDQLREAAVGTLVSGVGWLVGATPPPREQRDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGH4</accession>
    <name>G0SGH4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription initiation factor TFIIE (Alpha subunit)-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0066340</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696931.1">
        <property type="nucleotide sequence ID" value="XM_006696868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGH4"/>
    <dbReference type="STRING" id="759272.G0SGH4"/>
    <dbReference type="GeneID" id="18260672"/>
    <dbReference type="KEGG" id="cthr:CTHT_0066340"/>
    <dbReference type="eggNOG" id="KOG2593">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035744_1_0_1"/>
    <dbReference type="OMA" id="ILIRYPC"/>
    <dbReference type="OrthoDB" id="361102at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039997">
        <property type="entry name" value="TFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017919">
        <property type="entry name" value="TFIIE/TFIIEa_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002853">
        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024550">
        <property type="entry name" value="TFIIEa/SarR/Rpc3_HTH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097:SF7">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02002">
        <property type="entry name" value="TFIIE_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00531">
        <property type="entry name" value="TFIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51344">
        <property type="entry name" value="HTH_TFE_IIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH TFE/IIEalpha-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="298"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="335"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS17313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="350" mass="40018" checksum="6C7757A835ED244D" modified="2011-10-19" version="1">MDVAQTLVRSVMRAFYTTQEILVIEALVTHSVLRDDELAYLMKMNLKDLHRLCAGLRDARFLVVHTRPEMQQGKTRPVNRTYYYIDYRQTIDAIKWRVYKTDKDMQGIAKPADEAKEYFCPRCKAQWTQLEVLDSCSQLGFTCQRCGTVLERSQERETPGHQQLSRMNNQFKFMTDMLQQIDKQVVPECTFEKALANARPIVRDAAHEVAPSVPVDTSTYNKPSAVKGLANVGPKTMQVTISDGNDEQERLEEKRRKERLLKENALPSWITESSVPTTSNFSTIIQPQTRSFEMVDAHDDSSKPASKRVKLEDGAAAEVKVEGNNGTMEMSFKMEEEDADEDDLEFEDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGL1</accession>
    <name>G0SGL1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coenzyme Q-binding protein COQ10 START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0066720</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with coenzyme Q.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the COQ10 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696968.1">
        <property type="nucleotide sequence ID" value="XM_006696905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGL1"/>
    <dbReference type="STRING" id="759272.G0SGL1"/>
    <dbReference type="GeneID" id="18260710"/>
    <dbReference type="KEGG" id="cthr:CTHT_0066720"/>
    <dbReference type="eggNOG" id="KOG3177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079653_1_1_1"/>
    <dbReference type="OMA" id="QLHAAMM"/>
    <dbReference type="OrthoDB" id="292693at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07813">
        <property type="entry name" value="COQ10p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044996">
        <property type="entry name" value="COQ10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901:SF10">
        <property type="entry name" value="COENZYME Q-BINDING PROTEIN COQ10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901">
        <property type="entry name" value="SPERM PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coenzyme Q-binding protein COQ10 START" evidence="5">
        <location>
            <begin position="87"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="17"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS17350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="290" mass="31709" checksum="7B44015F35C91547" modified="2011-10-19" version="1">MPPRLLPFLRRPQSLLSSRPTQLLSQIPTFSPTSHPGPTTQSPSILSRTPRRPSTTWLLSALSSLAPSPGGAPRPPPPKTLRARRVLPYPPTHIYRLIADIDSYRLFLPHCTHSLVTRWTRPLPTSQNNGNGGEGTELPVRHPVLADLTVGWGPFTQTYTSRVYCVPGEIVEAVSGSASTTIPREILKAVGYEDADLSRETTMEGVFESLVTRWTVEPVTRSAAAVATTTIPRLTTEVAGSDGVWTEVALSVTFQFTNPALGFAVGQLADDKVDEMVQAFEQRARETYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGU0</accession>
    <name>G0SGU0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sacsin/Nov domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0067550</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697047.1">
        <property type="nucleotide sequence ID" value="XM_006696984.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0SGU0"/>
    <dbReference type="GeneID" id="18260793"/>
    <dbReference type="KEGG" id="cthr:CTHT_0067550"/>
    <dbReference type="eggNOG" id="ENOG502QPMA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001744_1_0_1"/>
    <dbReference type="OMA" id="VYWWVIL"/>
    <dbReference type="OrthoDB" id="10031156at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022155">
        <property type="entry name" value="DUF3684"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058210">
        <property type="entry name" value="SACS/Nov_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF047352">
        <property type="entry name" value="P_loop_sacsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12449">
        <property type="entry name" value="DUF3684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25794">
        <property type="entry name" value="SACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacsin/Nov" evidence="2">
        <location>
            <begin position="26"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1433"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1521"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1765"/>
            <end position="1805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1433"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1448"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1489"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1529"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1775"/>
            <end position="1793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1794"/>
            <end position="1805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1805" mass="199643" checksum="2DD6BA053CAA97E4" modified="2011-10-19" version="1">MDYARLRAAALSGEVEEAVTVDTRALIDKVLARYSGEWTTLRELIQNAADAQASTVTVKWETIPSTSVPLPQNATPSDLLQHTLRHHTIRRLVVQNDGLPFSKTDWQRLKRIAEGNPDETKIGAFGVGFYSVFADCEEPFVSSGAEAMAFYWKGNALFTRKVTLPEDQQSKLTTFVLDYRSTTTPVPNLLSVAQFLATSLTFVALQRIEFWIDEWRVLGLVKKSSPSMEVLVPRSLETTTREKHFRLTAAERMSTQIDATFMHVLGWKPQTTSSTSKLAETTFGSELSSLKGFFSRLTGVSSQTKAAKEEKSLQDTVAQDLTATSTSTIFLRSISAQFVTSVSSSFAAELERATKKPPPKITRISILTSSYDETVASEEASSAAAAKIADVFATVLPSKKPGGRIFIGFPTMQTTGAGMHVSAPSVIPTVEREAIDLNARWVRTWNVEMLRATGILARLAFASEMAELDQKLKRMAQANGDNKKKGGVVVSAAADVQKCVPEALHILKTYTFTESTPNAYVAQIIEEGFWTACKEPFIEVFSSRGVLPSTKVRNSSEEIARFVAGIPVVLKEMRDAPLIRKLVDFGLIQDVTVEDIAQELGNKALDREQLGHFLQWITKGAAEGELDRPSVQRLLDVAVATVSADGADSGEVIALGSIKYYHNKLIPAHLPIPPTTMPVAFTASIPEGKLLSLGWSPLSLVLWLQFLIESAPTKPAEQDLTRSDKFAHQVLSVLSKNWDNLSPNSRATVVGLLQNITVMPTKMGMRKPGESFFPSVKLFDDLPTLEGCINLKEKFLVALGVRKTVDLETIFTRLLTPGEGDAQGAKWSHVELIKYLTSVRQDIPAADLKKLRESPLCPAEAGPKGAEASKRSERLYRVCELYEPKDSLRALGLPILQWPGPSGSFRSNSPEAKFLFSLGLKAYPSAEQLVEMMASQDEELRGNAMAYFIANHHLNGYTSTDLAGTDKRILPIEGNEKVLVTPSACYTNERAAVMGYNILRRDLHPHAMKFGVARDPPISGCVEKLIANPPADRQAAVTLFEYLTSRLGDLRHNDLMRLRDAAIVPVVRSASAAGKSGKPTVVLVAPSRVYLGSSSTYKDIFDFVDFGADANSFLFKCGAKSEPTKHEIAHLACTEPARLLSVLESPEKYLSLLKSIAEDLSTLKRDRDLYRKMKTSPWLLGSKEVPSGKNRSTDDDEEEEDATIKSYLLASPPQLTILDDFISYRLFKDSLLCAPEEDLLEDMYLALGATTLSSRVQEDLRIGRPTPDQRSAEWLRKHVLERAKLFLHEYAKDRPNAVKHDYRWLEKNLRVISVASLALRRTLRGVQGGRVHAESRSAASMKTSEGHVLYVAAPEGGEGKPDMYQVGQAICQMLLTRPNQHAYFFFEPFLKLGLLELRARGYNVDRILRAKAAEARLAEEEKRRALEAERQKLEVEERERKRVKEQEQQQQQQQRQQQRGVQTPRQGARMPGAFEEDSPEQEQALVRSHSGQQQHQPEQTTTVRSLFNAFTRRLGIDVDTLTSPQSQQQPPPKQPESKPFPSPLAPLPPTSSDNDPITGPLTSPSSLRRTLLTAIQQTRAHTSPELISPPAQTTVPELPLYCDSTPAEHISFVAEAPRGMHVFLPKGMTLQATEFVTQHAEAIGLFEGVLRDVVAVYELPSPGVVSIFWERGKTVAFNRAGSLFCNLAYFEELHVHGVKTNHGGMGRVEAVTWWWVVLAHELAHNLVSVHDAKHGYYTESFLQQYFAKMMALAAQWLNAPASSVTAAGGARGSETRTLPSSSSSGRLQREPSLPLEPPPPYSPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGU1</accession>
    <name>G0SGU1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0067560</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697048.1">
        <property type="nucleotide sequence ID" value="XM_006696985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGU1"/>
    <dbReference type="GeneID" id="18260794"/>
    <dbReference type="KEGG" id="cthr:CTHT_0067560"/>
    <dbReference type="HOGENOM" id="CLU_1704015_0_0_1"/>
    <dbReference type="OrthoDB" id="5571888at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF82">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409154" description="Heterokaryon incompatibility domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="3">
        <location>
            <begin position="59"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS17430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="154" mass="17233" checksum="C2F86FF03860C0E4" modified="2011-10-19" version="1">MVRVSIYALISVISFAAFGAGSGRKEGSDTWQPVGGYPRSNGNDSNSNSSTSSELIGILLWIDTLSINQADMSERNSQVLLMGEVYRNATSVLSWLGEHPLLSRALKCPASKIDSRTRNDLREKLGREWLESTKKMWQDDKNLESIVKFVEEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGX0</accession>
    <name>G0SGX0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Elongation factor 1-gamma-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0067860</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697077.1">
        <property type="nucleotide sequence ID" value="XM_006697014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGX0"/>
    <dbReference type="STRING" id="759272.G0SGX0"/>
    <dbReference type="GeneID" id="18260824"/>
    <dbReference type="KEGG" id="cthr:CTHT_0067860"/>
    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_3_0_1"/>
    <dbReference type="OMA" id="TQYFSWT"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03181">
        <property type="entry name" value="GST_C_EF1Bgamma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03044">
        <property type="entry name" value="GST_N_EF1Bgamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000006">
        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000142">
        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1010:FF:000001">
        <property type="entry name" value="Elongation factor 1-gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1010">
        <property type="entry name" value="Translation elongation factor EF1B, gamma chain, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050802">
        <property type="entry name" value="EF-GSTs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001662">
        <property type="entry name" value="EF1B_G_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036433">
        <property type="entry name" value="EF1B_G_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986:SF1">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00647">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01183">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89942">
        <property type="entry name" value="eEF1-gamma domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50040">
        <property type="entry name" value="EF1G_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="7">
        <location>
            <begin position="2"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="8">
        <location>
            <begin position="86"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="EF-1-gamma C-terminal" evidence="6">
        <location>
            <begin position="253"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="211"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS17459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="413" mass="46883" checksum="49288A3F335BC1EC" modified="2011-10-19" version="1">MAFGKLYSYPGNPRTTGIRAVAKANNLEIEEVETDVKNPSEEFLKVNPIGKVPAFAGADGFNLTECIAIAVYFASQNEKTTLLGKTKQDYASILKWMSYFNSEVLPKLGGWFRPLLGKDPYNKKAVEESSKAALAAIAIVEKHLADKTYLVGERLTLADLFATGIIARGFEYFFDKEWREKNPHVTRWYTTVYNQPVYSAVAPEFTLLDTPKLTNVPPKKPEAPKKEAKKEAPKKEEAPAAAAEEEPAPAPKPKHPLESLPKASMPLDEWKRQYSNQETPDALKWFWEHVNFEEYSLWKVRYKYNDELTLTFMSSNLIGGFNNRLEASRKYLFGCASVFGKNNDSIIEGAFLIRGQDYLPVFDVAPDYESYEFTKLDPNNPADREYVELQWSWDRPLVVDGKEYPHAAGKVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0SH97</accession>
    <name>G0SH97_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0069230</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697204.1">
        <property type="nucleotide sequence ID" value="XM_006697141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SH97"/>
    <dbReference type="STRING" id="759272.G0SH97"/>
    <dbReference type="GeneID" id="18260961"/>
    <dbReference type="KEGG" id="cthr:CTHT_0069230"/>
    <dbReference type="eggNOG" id="ENOG502SP8Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021768_6_1_1"/>
    <dbReference type="OMA" id="FFPVWWE"/>
    <dbReference type="OrthoDB" id="8300194at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF48">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="306" mass="35497" checksum="D1936F2014381959" modified="2011-10-19" version="1">MSRRHMNRFTIEQVLDIAEVIHSRGSRKVWRIGDYILKQTPYEGVNNEVATLRFVQQHTTIPVPVVYDEWLSPDRRFHYILESRIPGKSLKQCWGVLSRKGRERIARTVLKYMQELSQFRSDRLESISSNKLRLNNFVPKPYKVLLNIWRTDNDIFDNEYRPALLSSGVDDGVILVLKNTMPPCQGQYTLTHGDLFTGNIIVDPVKEQVTGIIDWESAGFWPAWFQYARITLGAGGWDDEWKALLSRAMKATHLPPHSKHGRIWWDAVYELLDHPGSSLAREWIKEIIRYLAGENVSLNNYDGFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHE0</accession>
    <name>G0SHE0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWR1-complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0069690</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SWC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697247.1">
        <property type="nucleotide sequence ID" value="XM_006697184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHE0"/>
    <dbReference type="STRING" id="759272.G0SHE0"/>
    <dbReference type="GeneID" id="18261007"/>
    <dbReference type="KEGG" id="cthr:CTHT_0069690"/>
    <dbReference type="eggNOG" id="KOG4776">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062474_2_0_1"/>
    <dbReference type="OMA" id="EMISIPH"/>
    <dbReference type="OrthoDB" id="445677at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011421">
        <property type="entry name" value="BCNT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027124">
        <property type="entry name" value="Swc5/CFDP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48407">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48407:SF1">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07572">
        <property type="entry name" value="BCNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51279">
        <property type="entry name" value="BCNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BCNT-C" evidence="5">
        <location>
            <begin position="153"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="33"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="106"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS17629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="232" mass="25854" checksum="EDD22EC51573AE93" modified="2011-10-19" version="1">MRAAEKEGKYAKIPKGPVTIDVDKLWQDLISAPVVRVPGQDTTATTQPQPNGDAQKPSQSKPVPNAADESEYIRIKRTYTFAGKTHTEEKLVHRESAEAKLYLAETGQDPSAPAVSPSDADQQQKRMPRKAFRSAFEPVPADGTGVSQRSDLNLGIAKLREQREKAEQAKKLNTVEKSRMDWAGYVDREGIKDELEMAGKSKHSFVARQEFLARSEAVREEEVRRLRLAGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHG1</accession>
    <name>G0SHG1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0069900</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697268.1">
        <property type="nucleotide sequence ID" value="XM_006697205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHG1"/>
    <dbReference type="STRING" id="759272.G0SHG1"/>
    <dbReference type="GeneID" id="18261028"/>
    <dbReference type="KEGG" id="cthr:CTHT_0069900"/>
    <dbReference type="eggNOG" id="ENOG502SD76">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047846_1_0_1"/>
    <dbReference type="OMA" id="ENVPIYN"/>
    <dbReference type="OrthoDB" id="5405126at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS17650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="394" mass="45546" checksum="47DB65BA057B5357" modified="2011-10-19" version="1">MFGASSTQSAFRAALSRPWLPLRQSAVFQQRALSTTRPQYLKQVITFSEKTSSPELKNLIQEFNQRIVMPTYLPPEQQKKIYREKFKVELENDPITIEIDGVVHKFRYVDRFTLPHVKKLVTDILRLMKEPQDFLNLPPLLEGCKRAHRKLPDHFHLKMVRMAAQAKMLPVILDMFLQADKTGFLLDNSELLNEVLVWIQNVAIESGWQKAEIKRALERVKLIINEIEADELHHPTDAKRCLRMFHRDPQVLAARLHMAAALAVHHRGSKDVDGKVTKWAEEIVELWPENTGLLNMQPEENYLDDNKLKYLLLPNQFLFYASPILSGLVMATQVVEDPALQMQLQNRADAVEAEIRLALQKMEEEGKTGRGLTMYNKLFARDESEEGAKDESEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHK6</accession>
    <name>G0SHK6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0070350</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697313.1">
        <property type="nucleotide sequence ID" value="XM_006697250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHK6"/>
    <dbReference type="STRING" id="759272.G0SHK6"/>
    <dbReference type="GeneID" id="18261073"/>
    <dbReference type="KEGG" id="cthr:CTHT_0070350"/>
    <dbReference type="eggNOG" id="ENOG502SPQT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098340_0_0_1"/>
    <dbReference type="OMA" id="PWFEEMI"/>
    <dbReference type="OrthoDB" id="3907216at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.70">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS17695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="29730" checksum="B18D1541F184B75D" modified="2011-10-19" version="1">MPPAPILQSTADWTGLDYLLHGGCHCGRNRYIVQLPKDPDIRRQAQVIIHRSSPPSLTGLLPLYLRIPLTWYHSQTIPLHSNESPTQIRVVYEPPAVTLQANSQPFETGTTTTTTEKRYFCGFCGTPLAFWHESPADEADYIQLALGSLSPGDLTDLEELGLVPDLGSNPASGEIDAYARENPAEGDKAIKKGKGLSWLDQWLEESRFGTLRRATGGEETRTESGTVRVEWEVMEWAPGEGEGEWGECLGKRKFQEVEGGGGLQERPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHX7</accession>
    <name>G0SHX7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GPI transamidase component-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0073730</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGU family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697629.1">
        <property type="nucleotide sequence ID" value="XM_006697566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHX7"/>
    <dbReference type="STRING" id="759272.G0SHX7"/>
    <dbReference type="GeneID" id="18261411"/>
    <dbReference type="KEGG" id="cthr:CTHT_0073730"/>
    <dbReference type="eggNOG" id="KOG2552">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030193_0_0_1"/>
    <dbReference type="OMA" id="ALWHLWI"/>
    <dbReference type="OrthoDB" id="549017at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009600">
        <property type="entry name" value="PIG-U"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN ANCHOR BIOSYNTHESIS CLASS U PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06728">
        <property type="entry name" value="PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="381"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS17047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="425" mass="46934" checksum="DA02BAE12B858022" modified="2011-10-19" version="1">MDGGKVTLGRAAGLYAGAAVLRLAIFSLLPALPDLLTGRVEISTPVTSFKRLQEGLFLYNHNVSPYDGGVYHQAPLFLPLFSLLPSYATFPFLTNFLYVIVDLLSANALWKIAESGEAGASAHFTSPRREKRWSGFVIAATFLFNPFTVATCIGRSTSVFTTCAILHAVAKAVSGAPFGAMAALAFASYLSMYPLLLLPPIMLLAYDRQNPTRAIRSPLKFSLACTTTVALISAALLGMSYLLTGSWEFLAATYGVQLTLSDLTPNVGLWWYFFIEMFDSFRSFFLAVFWLHLSCYVGGLCVRIRSQPLAVITLLLGIFAIFKPYPSISDTSLFLALVPLYRHVLPLMRYSFVIAAVILYCVLLGPAFYHLWIYAGSGNANFFYAITLVWGLGQSLLVCDLMFAVLRDEWEVERPEMVGKEIRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G1DJ98</accession>
    <name>G1DJ98_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH-ubiquinone oxidoreductase chain 2</fullName>
            <ecNumber evidence="3">7.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NADH dehydrogenase subunit 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_m000270</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="12"/>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="14 15 16" key="2">
        <citation type="journal article" date="2022" name="Sci. Adv." volume="8" first="eadc9952" last="eadc9952">
            <title>Conformational changes in mitochondrial complex I of the thermophilic eukaryote &lt;i&gt;Chaetomium thermophilum&lt;/i&gt;.</title>
            <authorList>
                <person name="Laube E."/>
                <person name="Meier-Credo J."/>
                <person name="Langer J.D."/>
                <person name="Kuhlbrandt W."/>
            </authorList>
            <dbReference type="PubMed" id="36427319"/>
            <dbReference type="DOI" id="10.1126/sciadv.adc9952"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.44 ANGSTROMS)</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 2 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="JN007486">
        <property type="protein sequence ID" value="AEI26006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004769779.1">
        <property type="nucleotide sequence ID" value="NC_015893.1"/>
    </dbReference>
    <dbReference type="PDB" id="7ZM7">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.77 A"/>
        <property type="chains" value="2=1-571"/>
    </dbReference>
    <dbReference type="PDB" id="7ZM8">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.76 A"/>
        <property type="chains" value="2=1-571"/>
    </dbReference>
    <dbReference type="PDB" id="7ZMB">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.75 A"/>
        <property type="chains" value="2=1-571"/>
    </dbReference>
    <dbReference type="PDB" id="7ZME">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.83 A"/>
        <property type="chains" value="2=1-571"/>
    </dbReference>
    <dbReference type="PDB" id="7ZMG">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.44 A"/>
        <property type="chains" value="2=1-571"/>
    </dbReference>
    <dbReference type="PDB" id="7ZMH">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.47 A"/>
        <property type="chains" value="2=1-571"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G1DJ98"/>
    <dbReference type="EMDB" id="EMD-14791"/>
    <dbReference type="EMDB" id="EMD-14792"/>
    <dbReference type="EMDB" id="EMD-14794"/>
    <dbReference type="EMDB" id="EMD-14796"/>
    <dbReference type="EMDB" id="EMD-14797"/>
    <dbReference type="EMDB" id="EMD-14798"/>
    <dbReference type="SMR" id="G1DJ98"/>
    <dbReference type="STRING" id="759272.G1DJ98"/>
    <dbReference type="GeneID" id="11030315"/>
    <dbReference type="KEGG" id="cthr:CTHT_m000270"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00445">
        <property type="entry name" value="NDH1_NuoN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010096">
        <property type="entry name" value="NADH-Q_OxRdtase_suN/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22773">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="14 15 16" id="KW-0002">3D-structure</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="366"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="427"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="530"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:quinone oxidoreductase/Mrp antiporter transmembrane" evidence="11">
        <location>
            <begin position="143"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEI26006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="7ZM7"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="7ZM8"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="7ZMB"/>
        </source>
    </evidence>
    <sequence length="571" mass="64091" checksum="7D2FB36A176A3A92" modified="2011-10-19" version="1">MIMISILSLLLSTSVTLRRDMSILFNRISIIALAYCILHDTMSLSFISKGIGLHGGLLHITNLTQIFHIFIFIISILILQLTSFYPRKVWIPEYSSLKDIFFNKILYYRTKIINKMGEHMKIIEYPLILLFVISGAVFLISTNDLVSIFLSIELQSYGLYLLSTIYRNSELSTTGGLIYFLLGGLSSCFILLGTSLLYVNSGTTSLDGLYILNSISDVNPVVAGVGEDGGLTSWYKPYYLNFSLLIFSIGFLFKVSAAPFHFWSPDVYDAIPTIVTTFVAIIAKISIFIFLLELVYYTNSNANSYLSEFSWTYALLISSLLSLIIGTVVGLTQFRIKRLLAYSTISHVGFILLALSVSSIESTQAFIFYLIQYSISNLNAFFILITIGFSLYGYVTNNKEYKSLLDKNNSPIQLISQLKGYFYINPLLSLSLAITIFSFVGVPPLVGFFAKQMVLSAALDNGYIFLSLIAIITSVIGAVYYLNVIKEIFFYSPEHEVNPVLNESDSNFSLRILNEKNVLIRSVLLKGRNIFISSPFSITISIITNVILLFIFMNKEWLSMGTILVQILFSA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-06-17" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>P9WF02</accession>
    <accession>G0SA92</accession>
    <name>ODBB_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2-oxoisovalerate dehydrogenase subunit beta, mitochondrial</fullName>
            <ecNumber evidence="1">1.2.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ORF">CTHT_0041430</name>
        <name type="ORF">CTHT_0041430-1</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:13458"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotetramer of 2 alpha and 2 beta chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EGS19664" version="1"/>
        </conflict>
        <text>The predicted gene CTHT_0041430 has been split into 2 genes: CTHT_0041430-1 and CTHT_0041430-2.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="1"/>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19664.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694549.1">
        <property type="nucleotide sequence ID" value="XM_006694486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P9WF02"/>
    <dbReference type="SMR" id="P9WF02"/>
    <dbReference type="GeneID" id="18258181"/>
    <dbReference type="KEGG" id="cthr:CTHT_0041430"/>
    <dbReference type="OrthoDB" id="878at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007584">
        <property type="term" value="P:response to nutrient"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00748">
        <property type="entry name" value="F_ACTIN_CAPPING_A_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00749">
        <property type="entry name" value="F_ACTIN_CAPPING_A_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0630">Potassium</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000450358" description="2-oxoisovalerate dehydrogenase subunit beta, mitochondrial" evidence="2">
        <location>
            <begin position="41"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <note>ligand shared with alpha subunit</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>structural</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P21953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="469" mass="50998" checksum="9EEB2BBC99C13B42" modified="2020-06-17" version="1" precursor="true">MKRSTVVIRPSARALSRQASSQSFLLARSSALTSRQRRLYSTHPPNARLNLPIDYATTPLLAHTSQAALSNPELPASVRNGTTKRMNLFQAINDALSTALAEDESVLIFGEDVAFGGVFRCTTKLAETYGGDRVFNTPLTEQGIMGFAIGAAAEGMRPVAEIQFADYVFPAFDQLVNEAAKFRYRDGAGGRSAGGLTVRMPCGGVGHGALYHSQSPEALFTHIPGLKVIIPRGPVQAKGLLLAAIRSNDPCVVMEPKILYRAAVEQVPTTAYELPLGKAEILKEGKDVTVVSYGQPLYKCMAALKAAEQDFGVSVELIDLRTIYPWDKETVFNSVRKTGRCVVVHEAMVNAGVGAEVAAAIQEDPETFVRLEAPVARIAGWSIPTPLVFEQFNLPDVTSKCYLTLGLADVYADGMPRDIRRHQKGDEFLRDLSMNSGILKQSMLHSSRRGVDWLMGIVLDDIILSVFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2023-02-22" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>G0RXT9</accession>
    <name>G0RXT9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0000360</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988030">
        <property type="protein sequence ID" value="EGS24105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690591.1">
        <property type="nucleotide sequence ID" value="XM_006690528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RXT9"/>
    <dbReference type="GeneID" id="18254074"/>
    <dbReference type="KEGG" id="cthr:CTHT_0000360"/>
    <dbReference type="HOGENOM" id="CLU_1454220_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS24105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="186" mass="19810" checksum="10A249E6CCB052BA" modified="2011-10-19" version="1">MFTPNGHSSSDKSISSEKIFVAASSTSGGDIFGTLQTSVTTTTQTATKAAPHHEPLFGAPSKPSGLSVTFPISKPFGEFAANDSKPFPSTSDDTYSSPNNFVSGTTPPGTTPNTNDMGLFDKSLLRAALECIGANFMNHYVVQHGIESASVGKDLFRIDDIPIDFRSPQPVEYFDKIIERSQVGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0RY19</accession>
    <name>G0RY19_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0005090</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691047.1">
        <property type="nucleotide sequence ID" value="XM_006690984.1"/>
    </dbReference>
    <dbReference type="GeneID" id="18254547"/>
    <dbReference type="KEGG" id="cthr:CTHT_0005090"/>
    <dbReference type="eggNOG" id="ENOG502S0T9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003774_1_2_1"/>
    <dbReference type="OMA" id="GICNCGH"/>
    <dbReference type="OrthoDB" id="298344at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018866">
        <property type="entry name" value="Znf-4CXXC_R1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10497">
        <property type="entry name" value="zf-4CXXC_R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="JmjC" evidence="6">
        <location>
            <begin position="168"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="851"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="909"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="961"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1010"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1059"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1129"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1145"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1184"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1195"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1232"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1270"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1393"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1407"/>
            <end position="1422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS23805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1422" mass="159797" checksum="9F400CFAEFA6D27F" modified="2011-10-19" version="1">MPTALHPQAKFDPIPPDLDLHGLVERTPNFHWVLRVPAAQIRKLGPQEFERLVYLHVVRGGKPLVIEKWNDWLPKSLFSARWLEATYNKKPEIVRDIVAQADIPMTMGHYLRSMKQLANQWTPHNFRDERRQRLYLKDIDCPPEWAAHLATIIPPNLWYLNENVDERPGKARNDDLNLFPSGLSPAPAGDLMSSLPEEMRAQNLMCYIGHEGTYTPAHREMCGSLGHNIMVDASGDENGEKPGSSIWFMTETKDREVVREYFLSMLGHDIEIEKHFAQINAWKKATFPVYIVEQKVGDFILIPPLAAHQVWNRGTRTMKVAWNRTTVETLQNALHEALPKARLVCRDEQYKNKAIIYYTLDKYYKIMTEAEKTADIGFLGFAQDLIKSSTRMKQLASDFKALFKLYTEILVDEMFATREKEVEYIPYDSNITCSYCRANIFNRFLTCKNCIRTLVTGDEDTYDICMECYIMGRSCFCVSNLTWCEQWRWSELVDKYETWRALIIKNDGYISFDSSPLPLELERKRTGKKSAAQICQEQLRKRPFNDITKVKQMPDHEGSEIEVDENGRRIKKKGRKKKKGNVYRCHVCAHKDYTYKLAFCTNEGCTDAYCYGVLYRAFDLMPQDVMQNERWQCPKCLEICNCGSCRRAGNGTPYIPKSTFIGHDTRRIADDRSVESLVDFRVHNLSWLKIGGDEGRSVSSKRMQRLLQAAEAEKAKHVELVGDGLTNGVIAQTLTAALQQSAANGCSAQGKNAEPDVAPMGVYPAPGVESIREHARPVVVAGASIRGDESSYPDPTILGRKRMLGMGYYEQDDSPDKILFDPYQAPTTESLVINDEPKMSEYLKKQLRLAKRRAHQEEDGDPDFRASRSHYRKKPKLDDNQPVQRDHQEIALSNMDPALFNAYTTITEAPTNGEQRALPPETAPQRTAEPSIEPLASAAPREESLHRPVLRHARSKMSYAEQNNAEDDIDEVINPRLQKPPESITYFNGDDAEKDPLDVAAAAVRSMAAPTAAAAPVVPPTPNIPTTTGTGRKRGRPRKSEAAPPQLEPQREPTPQPEPGREQKREGSQPEQPRRRRGRPPKARPSTSAPPESEKEPEDDIDAQLARPLDAFNDNGEAIAQEAEQALTEEVRVAPEPPRRRGRPPRNPQPKPQPQPSPPPARRTEFMIELPSQPLMSITERMRMRGKKVKIVGRKSTSQGSAAPVSSKSATPARESIHRETGSARSSVARETPPRRRTTEEIDKDFDPTAEEEAASTDRRAFTRATAPRSTSISASLSRSCSHSLPALAAIEPSASASEESQSESRSRSPHPLPRVPFGLTIIRLGDDSDDEEDGSYQACDSRDQESGSEYGAGRGRLDAAAATQEPVSEYESSDDEDEDIPARKLTASVNGRGSGHRGWGGARGGGRGRGRRDRGRGRKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G0RY35</accession>
    <name>G0RY35_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0005260</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691063.1">
        <property type="nucleotide sequence ID" value="XM_006691000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RY35"/>
    <dbReference type="STRING" id="759272.G0RY35"/>
    <dbReference type="GeneID" id="18254564"/>
    <dbReference type="KEGG" id="cthr:CTHT_0005260"/>
    <dbReference type="eggNOG" id="ENOG502RX7P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057565_0_0_1"/>
    <dbReference type="OMA" id="PRIECQL"/>
    <dbReference type="OrthoDB" id="4001642at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053060">
        <property type="entry name" value="Cytokinesis_Signaling_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36419">
        <property type="entry name" value="ARRESTIN FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36419:SF1">
        <property type="entry name" value="RHO1 GEF LOCALIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="1">
        <location>
            <begin position="190"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="406" mass="45071" checksum="E57C602BA1498B16" modified="2011-10-19" version="1">MNAPNIPAVVRISGPPNSSFLVGYPGISATLPRIVGKVEIRPGAGISAPVNISMVRICLQRRETIHPSAENVAKRHLGTPRRETVETVGKEVLLFRCMTGKEAESVIAMDLPFQIFIPFGRSGEESNRRIPPASLQLPSRIAETYYELVVTVQQGSSMQNRYTFPVQLQRYDTLSTFGMYNRPETRAATADHIVTLGISLPKWSYGPLDPITVYVKLSPNPDYMSKAKKVTIQKITLTIEEEITFNPEGDEPTKKVTKIAKHTQTVGTKLPETGYMTNLGLVLPARNLRDPDGIIKRGKPHFPQYEVTSFTTTSTLYKIEFFLSVKAHMTSARDITLRQPIVVCPLDQQACKEEMEAIEQAAKDASMVDPNNPVLPERMIVLASEKDAIRHLGLCEVGGVKKMLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0RY92</accession>
    <name>G0RY92_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">U6 snRNA-associated Sm-like protein LSm1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LSM1</name>
        <name evidence="14" type="ORF">CTHT_0005870</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the heptameric LSM1-LSM7 complex that forms a seven-membered ring structure with a donut shape.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with SLBP; interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase. LSm subunits form a heteromer with a donut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691120.1">
        <property type="nucleotide sequence ID" value="XM_006691057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RY92"/>
    <dbReference type="STRING" id="759272.G0RY92"/>
    <dbReference type="GeneID" id="18254625"/>
    <dbReference type="KEGG" id="cthr:CTHT_0005870"/>
    <dbReference type="eggNOG" id="KOG1782">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_0_0_1"/>
    <dbReference type="OMA" id="RTWDQFA"/>
    <dbReference type="OrthoDB" id="10263346at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01728">
        <property type="entry name" value="LSm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000021">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034104">
        <property type="entry name" value="Lsm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF8">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 11" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="13">
        <location>
            <begin position="71"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS23878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="209" mass="23274" checksum="032A321ED35F7976" modified="2011-10-19" version="1">MDNFQNLSLNDPPPPHLGPPPAGFQQQQGQFHQQQQFPPQQPPVGGIPGGIPPQFGRPPPPPQQLPAQMFTTAAQLLDLTDKKLMVALRDGRKLIGILRSWDQFANLVLQSTKERIFIPPNTMPNQPRGLYADIDRGLFLVRGENVLLLGEIDLDKDDDPPPGYDLADVELVKQLAKQKRQQDKAKEKKKLKLLSKEGFEGESVGEVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYA7</accession>
    <name>G0RYA7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Selenoprotein O</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0006020</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SELO family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691135.1">
        <property type="nucleotide sequence ID" value="XM_006691072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYA7"/>
    <dbReference type="STRING" id="759272.G0RYA7"/>
    <dbReference type="GeneID" id="18254640"/>
    <dbReference type="KEGG" id="cthr:CTHT_0006020"/>
    <dbReference type="eggNOG" id="KOG2542">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010245_2_1_1"/>
    <dbReference type="OMA" id="YGPYGWL"/>
    <dbReference type="OrthoDB" id="10254721at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070733">
        <property type="term" value="F:AMPylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00692">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003846">
        <property type="entry name" value="SelO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057:SF14">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02696">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="42"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="387"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS23893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="762" mass="85563" checksum="8768A79DF76E360B" modified="2011-10-19" version="1">MSTSSSSSQATSHIACSYFPQVPGGYIPVRLGTRQGHWAADGGDDAPVCATNVPPLRNPLSRPRPSPPSITHPPSLLSSSAPVRILPSHGNTENNNDGLNRRWSPNRSSRRGFPPSNADNTQAQSPWPGVTLAALPKSWTFTSSLPPDPMYPTPAESHRTPRHEIHPRQVRHALFTWVRPEPQSTSELLAVSPAAMRDLGLLASEAETEDFKQTVVGNKLWGWDEEKETGEGYPWAQCYGGWQFGSWAGQLGDGRAISLFEATNPFTGARYEVQLKGAGITPYSRFADGKAVLRSSIREFIVSEYLHAIGVPTTRALAISLLPNERVRRERIEPGAIVVRFAPSWLRIGTFDLPRMRGDRELVRQLATYLAEHVIPGGWEALPARLEDPSSPPQDESILTPLTGIPPSEIQGSPGEEENRFARLFRHIARLNALMVASLQSYAFTNGVLNTDNTSLLGLSMDYGPFAFLDVFDPSYTPNHDDDTLRYSYRNQPTIIWWNLVRLAEALGELLAAGGEVDEEWFVSKGFSKFESEEATQPYVRRAEKIIAQAGQEYKAVFLAEYTRLMRRRLGFRTVNPDDLEGFISPLLDTMESLSLDYNLFFRTLSSIPLVPTPTPELWDTVLPKFFYPSTPPSSLPQDKAPLLKDLTTWLEKWHERIKQDWNNGNPLIPEIDQERIKAMKGVNPKFVPRGWIFDEVIRRVEKDGERNVLKRLLHLSLHPFEDNWAGREFDGVLYEGNKDEEERWTSDVPKVGRMLQCSCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYA8</accession>
    <name>G0RYA8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-keto ester reductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0006030</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691136.1">
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="416253at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H as acceptor"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19120">
        <property type="entry name" value="AKR_AKR3C2-3"/>
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        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
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        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
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        <property type="entry name" value="AKR"/>
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    <dbReference type="InterPro" id="IPR044494">
        <property type="entry name" value="AKR3C2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="26"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
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        <source>
            <dbReference type="Pfam" id="PF00248"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS23894.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
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    </evidence>
    <sequence length="304" mass="34305" checksum="58ADD2B5E2D2F44A" modified="2011-10-19" version="1">MSADQYEPIPTVKLSDGNEIPLLGYGLGTANFKRGNKDEINEKIIGDTLTALKVGYYHLDGAEAYGNERELGLAISRSGLPRHQLFVTTKTSCRQGESIETAFSRSLAALGLDYVDLYLIHSPFFSGPDPKPEELQAKWREMEAIKDSGRAKSIGVSNFLRPHLEAVLSIARHKPVVNQIEYHPYLQHDVDDLIQLHREQGIVIEAYGPLTAVTKAKPGPVDEVYERLAKKYGVEEGDVALRWCLDQGVVALTTSGKEERLRGFRERLPKFKLTEEEIQEISEKGRGKHYRGFWGHIFKEDDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYI5</accession>
    <name>G0RYI5_CHATD</name>
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        <recommendedName>
            <fullName evidence="16">RuvB-like helicase</fullName>
            <ecNumber evidence="16">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CTHT_0006820</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="journal article" date="2015" name="Structure" volume="23" first="483" last="495">
            <title>Structural basis for dodecameric assembly states and conformational plasticity of the full-length AAA+ ATPases Rvb1 Rvb2.</title>
            <authorList>
                <person name="Lakomek K."/>
                <person name="Stoehr G."/>
                <person name="Tosi A."/>
                <person name="Schmailzl M."/>
                <person name="Hopfner K.P."/>
            </authorList>
            <dbReference type="PubMed" id="25661652"/>
            <dbReference type="DOI" id="10.1016/j.str.2014.12.015"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.94 ANGSTROMS) IN COMPLEX WITH ADP AND ATP</scope>
    </reference>
    <reference evidence="22 23" key="3">
        <citation type="journal article" date="2016" name="PLoS ONE" volume="11" first="e0146457" last="e0146457">
            <title>The Combination of X-Ray Crystallography and Cryo-Electron Microscopy Provides Insight into the Overall Architecture of the Dodecameric Rvb1/Rvb2 Complex.</title>
            <authorList>
                <person name="Silva-Martin N."/>
                <person name="Dauden M.I."/>
                <person name="Glatt S."/>
                <person name="Hoffmann N.A."/>
                <person name="Kastritis P."/>
                <person name="Bork P."/>
                <person name="Beck M."/>
                <person name="Muller C.W."/>
            </authorList>
            <dbReference type="PubMed" id="26745716"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0146457"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.90 ANGSTROMS) IN COMPLEX WITH ADP</scope>
    </reference>
    <reference evidence="24 25" key="4">
        <citation type="journal article" date="2018" name="Nature" volume="556" first="386" last="390">
            <title>Structural basis for ATP-dependent chromatin remodelling by the INO80 complex.</title>
            <authorList>
                <person name="Eustermann S."/>
                <person name="Schall K."/>
                <person name="Kostrewa D."/>
                <person name="Lakomek K."/>
                <person name="Strauss M."/>
                <person name="Moldt M."/>
                <person name="Hopfner K.P."/>
            </authorList>
            <dbReference type="PubMed" id="29643509"/>
            <dbReference type="DOI" id="10.1038/s41586-018-0029-y"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.75 ANGSTROMS)</scope>
    </reference>
    <reference evidence="26" key="5">
        <citation type="journal article" date="2022" name="Sci. Adv." volume="8" first="eadd3189" last="eadd3189">
            <title>Structural mechanism of extranucleosomal DNA readout by the INO80 complex.</title>
            <authorList>
                <person name="Kunert F."/>
                <person name="Metzner F.J."/>
                <person name="Jung J."/>
                <person name="Hopfler M."/>
                <person name="Woike S."/>
                <person name="Schall K."/>
                <person name="Kostrewa D."/>
                <person name="Moldt M."/>
                <person name="Chen J.X."/>
                <person name="Bantele S."/>
                <person name="Pfander B."/>
                <person name="Eustermann S."/>
                <person name="Hopfner K.P."/>
            </authorList>
            <dbReference type="PubMed" id="36490333"/>
            <dbReference type="DOI" id="10.1126/sciadv.add3189"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (4.68 ANGSTROMS)</scope>
    </reference>
    <reference evidence="27 28 29" key="6">
        <citation type="journal article" date="2023" name="Science" volume="381" first="313" last="319">
            <title>Hexasome-INO80 complex reveals structural basis of noncanonical nucleosome remodeling.</title>
            <authorList>
                <person name="Zhang M."/>
                <person name="Jungblut A."/>
                <person name="Kunert F."/>
                <person name="Hauptmann L."/>
                <person name="Hoffmann T."/>
                <person name="Kolesnikova O."/>
                <person name="Metzner F."/>
                <person name="Moldt M."/>
                <person name="Weis F."/>
                <person name="DiMaio F."/>
                <person name="Hopfner K.P."/>
                <person name="Eustermann S."/>
            </authorList>
            <dbReference type="PubMed" id="37384673"/>
            <dbReference type="DOI" id="10.1126/science.adf6287"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS) IN COMPLEX WITH ADP</scope>
    </reference>
    <comment type="function">
        <text evidence="16">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="function">
        <text evidence="15">DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-16141763">
            <id>G0RYI5</id>
        </interactant>
        <interactant intactId="EBI-16141786">
            <id>G0RYC2</id>
            <label>CTHT_0006170</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>16</experiments>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="16"/>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691213.1">
        <property type="nucleotide sequence ID" value="XM_006691150.1"/>
    </dbReference>
    <dbReference type="PDB" id="4WVY">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.64 A"/>
        <property type="chains" value="A=1-462"/>
    </dbReference>
    <dbReference type="PDB" id="4WW4">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.94 A"/>
        <property type="chains" value="A=1-462"/>
    </dbReference>
    <dbReference type="PDB" id="5FM6">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="A=1-462"/>
    </dbReference>
    <dbReference type="PDB" id="5FM7">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="A=1-462"/>
    </dbReference>
    <dbReference type="PDB" id="6FHS">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.75 A"/>
        <property type="chains" value="A/B/C=1-462"/>
    </dbReference>
    <dbReference type="PDB" id="6FML">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.34 A"/>
        <property type="chains" value="A/B/C=1-462"/>
    </dbReference>
    <dbReference type="PDB" id="8AV6">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.68 A"/>
        <property type="chains" value="A/B/C=1-462"/>
    </dbReference>
    <dbReference type="PDB" id="8OO7">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="A/B/C=1-462"/>
    </dbReference>
    <dbReference type="PDB" id="8OOC">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.93 A"/>
        <property type="chains" value="A/B/C=1-462"/>
    </dbReference>
    <dbReference type="PDB" id="8OOP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="A/B/C=1-462"/>
    </dbReference>
    <dbReference type="PDB" id="8OOR">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.87 A"/>
        <property type="chains" value="A/B/C=1-462"/>
    </dbReference>
    <dbReference type="PDBsum" id="4WVY"/>
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    <dbReference type="PDBsum" id="5FM6"/>
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    <dbReference type="EMDB" id="EMD-17006"/>
    <dbReference type="EMDB" id="EMD-17010"/>
    <dbReference type="EMDB" id="EMD-17025"/>
    <dbReference type="EMDB" id="EMD-17026"/>
    <dbReference type="EMDB" id="EMD-3242"/>
    <dbReference type="EMDB" id="EMD-3243"/>
    <dbReference type="EMDB" id="EMD-4264"/>
    <dbReference type="EMDB" id="EMD-4277"/>
    <dbReference type="SMR" id="G0RYI5"/>
    <dbReference type="DIP" id="DIP-61384N"/>
    <dbReference type="IntAct" id="G0RYI5">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0RYI5"/>
    <dbReference type="GeneID" id="18254720"/>
    <dbReference type="KEGG" id="cthr:CTHT_0006820"/>
    <dbReference type="eggNOG" id="KOG1942">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028311_1_1_1"/>
    <dbReference type="OMA" id="RTLPYNK"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="EvolutionaryTrace" id="G0RYI5"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000001">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="20 21 22" id="KW-0002">3D-structure</keyword>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 16 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 16" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 16" id="KW-0234">DNA repair</keyword>
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    <keyword evidence="5 16" id="KW-0378">Hydrolase</keyword>
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    <sequence length="462" mass="50385" checksum="DB16D4AEB6CAEC81" modified="2011-10-19" version="1">MVQISEVRGNTRDHRTAAHTHIKGLGLNSSGIAEKQAAGFVGQCAAREACGVVVDLIKAHKMAGRGVLLAGGPGTGKTALALAISQELGTKIPFCPITGSEIYSTEVKKTEVLMENFRRAIGLRVRETKDVYEGEVTEMTPEEAENPLGGYGKTISTLLIGLKSARGQKKLRLDPSIYEAIQKERVQVGDVIYIETNTGACKRVGRSDAYATEFDLEAEEYVPIPKGEVHKKKEIVQDVTLHDLDVANARPQGGQDIISMMGQLMKPKMTEITDKLRMEINKVVQKYINQGVAELIPGVLFIDEAHMLDIECFTYLNKALESPIAPIVVLASNRGIATIRGADDLKAAHGIPPDFLQRLLIIPTHPYEPDEIRRIVRIRAQTEGVQLTDAAVDRVAEHGVRISLRYCLQLLAPASILARVNGRTQVDVQDIAEAEELFLDARRSANILTSTGESGGLHGFIS</sequence>
</entry>
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                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
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        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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            <begin position="86"/>
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            <end position="29"/>
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    </feature>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
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    </evidence>
    <sequence length="148" mass="16339" checksum="FD07040D2DCC1BE3" modified="2011-10-19" version="1">MSTFNLFKSKAREDDEDDRGEAIDSETIAGGGHSTEIAHHRLRVSQALRSFLAHEGLLSNEQDEEALNALLDRPVVSPPASVLDRSHPLPEYFISSSHNTYLLAHQLYGSSAAEAYETTLKAGARCIEIDAWYVFRIYFPGSTLTAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZ66</accession>
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    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="3" type="ORF">CTHT_0001870</name>
    </gene>
    <organism evidence="4">
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
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                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
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                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690736.1">
        <property type="nucleotide sequence ID" value="XM_006690673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZ66"/>
    <dbReference type="STRING" id="759272.G0RZ66"/>
    <dbReference type="GeneID" id="18254225"/>
    <dbReference type="KEGG" id="cthr:CTHT_0001870"/>
    <dbReference type="HOGENOM" id="CLU_1073634_0_0_1"/>
    <dbReference type="OMA" id="FHHARLY"/>
    <dbReference type="OrthoDB" id="20018at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="201"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="26"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="116"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="259" mass="27200" checksum="4AEF5DEDB7980917" modified="2011-10-19" version="1">MSASTSTSAAPPARLILPSLKRAQPSAPTVTLTTMTATASTTTVTRARSTAGSTACSSKSSSVQQPAQQSITGLSSSVSVQQEPNYTLSSGPSSERGTRTTTALQPSSSTTGSAVAPTSSSSITGTATPTPSTQTPARTPSTAPTTVTAPAPRTQAPQPQTRPTPDPQAFHHARLYLTTTLSHIFSSSHLPSLATDLHANDKALRSQLRSLEQATEGLRRENDKLERLVGEYEGKLKEVGMRSGSRRFAGVAWRGLRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZ85</accession>
    <name>G0RZ85_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0002070</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690755.1">
        <property type="nucleotide sequence ID" value="XM_006690692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZ85"/>
    <dbReference type="GeneID" id="18254245"/>
    <dbReference type="KEGG" id="cthr:CTHT_0002070"/>
    <dbReference type="eggNOG" id="ENOG502QSKG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_0_0_1"/>
    <dbReference type="OMA" id="KYVWAQK"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="39817" checksum="E88667D652DBB86B" modified="2011-10-19" version="1">MSGSEETKPTTTGLLPASHWKSLNVEEDDHSDASSFASSNASSTTSLRDSILEYRKILGRTYHHELGDAENWTPNDDKHTESMELVHYLTLVAMKNKLFHAPLNTDKLKKVLDVGTGTGHWAIDFGDQYPNVEVTGTDITPIQPAWTPPNVSWEIDDANQDWTWPENTFDFIHVRYLMGCIRNWKKFYQDAFRCLKPGGWLEHHESSSSWYSDTEGVGPDHTVAEDSPVGQTVKIFQSSGERIGRTFRVFEDELQQKLMKEVGFVDIGFKNYDVPIGSWPEDPEQKQLGILGGEALLGDLEGYMLYVLTKVEGWSEDEARTFTAHVRAQLRKPGFNPYFKRRAVWGRKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZE3</accession>
    <name>G0RZE3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein transport protein SEC31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein transport protein sec31</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CTHT_0002660</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SEC31 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690813.1">
        <property type="nucleotide sequence ID" value="XM_006690750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZE3"/>
    <dbReference type="STRING" id="759272.G0RZE3"/>
    <dbReference type="GeneID" id="18254304"/>
    <dbReference type="KEGG" id="cthr:CTHT_0002660"/>
    <dbReference type="eggNOG" id="KOG0307">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003033_2_0_1"/>
    <dbReference type="OMA" id="WLERPCG"/>
    <dbReference type="OrthoDB" id="542917at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.940.10:FF:000007">
        <property type="entry name" value="Protein transport protein (SEC31), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000193">
        <property type="entry name" value="Protein transport protein SEC31, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024298">
        <property type="entry name" value="Sec16_Sec23-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040251">
        <property type="entry name" value="SEC31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009917">
        <property type="entry name" value="SRA1/Sec31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923">
        <property type="entry name" value="SEC31-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923:SF11">
        <property type="entry name" value="SECRETORY 31, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07304">
        <property type="entry name" value="SRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12931">
        <property type="entry name" value="TPR_Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="7 15" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="116"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="250"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Sec16 Sec23-binding" evidence="18">
        <location>
            <begin position="551"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="SRA1/Sec31" evidence="17">
        <location>
            <begin position="1095"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="474"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="787"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="474"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="820"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="880"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="928"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="950"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="973"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="988"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1012"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1042"/>
            <end position="1116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF07304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF12931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGS23571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1235" mass="132727" checksum="0160479003514618" modified="2011-10-19" version="1">MVRLREIPRTAAFAWSPGTSSPLLVTGTRSGAVDADFSDESKLELWDLNLDVAEQGLELQPIASISTDSRFYDIAWGAPSDQHPRGVIAGAMEDGSLQLWDAAKLLAGEEALMSRDTKHTGPIKALQFNPLRPQVLATAGAKGELYVWDVNDTSTAFRLGSAAAQDIDCLAWNCKVANILATGSAGGFVTVWDLKTKKASLTLNNNRKPVSALAWDPNNSTSILTATSDDNTPVILLWNLRNSQAPERTLQGHEQGILSLSWCQQDTGLLLSAGKDNRTLVWNPHTGERYGEFPEATNWTFSTRFNPHNPNLSATAAFDGKIVIQTLQNTNPTAVPQTQAALDDDDFFSRAATQPQGVSFSLSRAPTWLERPVGVSFGYAGKLVIFKKHDTPAGQHRSSKITISTFSVDSDIGAATEKFEEAIKKGDIASICDSHIEAAKTEEEKADWQVLKTLSQDDGRSKIIEYLGFSKDEEARESGLTSPKEESAEGVTSPQTNGEEPKKKSHKRVTSMWGDIDDGDDFLSELTPAKGAKTDDPFHLIGEGSSVDDQITKAVLLGNFEMAVNLCVKEDRIADAFVLANCGGKELVDKVQSSYLAKKKGSTSYLRLINSVTSKNLWDVVYNADLSNWKEAMVTLCTFAEPAEFPDLCEALGDRIYESGERKDASFCYLVGSKLEKVVDIWIAELQEAEQAGLSEETNDTSFSIHARALQKFIEKVTVFRHVSKFTDNEKQLSEGWKLAALYNKYTEYADIVAAQGHLAVAQRYLDLLPANFPAAEVARNRVKLATQKAAPQPAGPTARVPSRTAAPVGYQQPGGLPSPANPYAPPAPTFQTQAPAPASAPNPYAPTTTSQYQPPTGASPYAPAPGFTPSPSITSGYAPPQPSFNQPPPPPQPKPYVKKDVGNWNDVPMVTKLPVRRSTPSAPPITSPFSNQAGTQTPPPPMGGYGRPQPTPPPPPPKGPAPPPRNTASPSVGPPPAAAQHPPRPGSVSSNASTNPYAPPPQPVSNILQPPVVPPPPRTSSPYNPPPAGPPPSNRYAPAPSSQPAPAAPPSASPYAPPPAMPPVAPPSQYGPPPQASRPPVGPPPRAGPPPAVSAPPPQQAPPQAPPQPQSPPPQQQKQRHPPGDRSHIPPNAKNMVEILDRDMQRVAAKAPSTFLPQVKDTQKRLGILFDHLNNSDLSDWTVSKLSELADALESKNYDVAHRLQVEIQTEKTGECGQWMVGVKRLISMSKATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZH3</accession>
    <name>G0RZH3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="12">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0002960</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="12"/>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690843.1">
        <property type="nucleotide sequence ID" value="XM_006690780.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0RZH3"/>
    <dbReference type="GeneID" id="18254334"/>
    <dbReference type="KEGG" id="cthr:CTHT_0002960"/>
    <dbReference type="eggNOG" id="KOG0262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000487_2_4_1"/>
    <dbReference type="OMA" id="NREDYQQ"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02735">
        <property type="entry name" value="RNAP_I_Rpa1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01435">
        <property type="entry name" value="RNAP_I_RPA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047107">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015699">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF11">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12 15" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="14">
        <location>
            <begin position="379"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="273"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1376"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1412"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1437"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="283"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1395"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1442"/>
            <end position="1468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS23601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1713" mass="191671" checksum="F91E560C5E814EE6" modified="2011-10-19" version="1">MNIAQPVGSSLESVEFTFLSPDEIRAISVKRIENDSTFDSLLNPVPGGLYDPALGSWGDALCRTCNLNQAQCPGHPGHIELPVPVYHPVFMDQAYRLLRAQCVYCHRFRLPRHEIHRYICMFRLLQVGLVHEAQMIDSFSVSDLGEQVRKLQLNDVPDIEDDEAQEEGNNIHDSTMRTREAYVRQVLQNYRKRVSIGDIRKGKHEGAAEMRRTLVKEFLAQMVKEKRCRSCDGISPVYRKDRWVKIYERDLTEKEKAAMAQAGRKRTDALALARKAKKHEDGMNDEGIADMELTDDSSEEHDSEGEGEELDENGDVVMTDAATKTKQKTVKAPKPNQRYLSTMEVRERLNLLFEREQELLSLLYSAKPRPKNSPPLTADMFFITTLLVPPNRYRPEARMGDNQISEAQQNNLYKMIIRAASRVAQISREIAGNKDAANEGRAIRDMSHLYQAWTELQDAVNSLIDRDKNPIQGAAAKRNEEGIKQKLEKKEGLFRKNMMGKRVNFAARSVISPDPNIETNEIGVPPVFARKLTYPEPVTSHNFKDLQQAVINGCDKWPGASAIENENGQIINLRSKSLEDRIALANQLLAPTGNNFSGVRNKKVHRHLTNGDVVLMNRQPTLHKPSIMGHRVRVLPGEKTIRMHYANCNTYNADFDGDEMNMHFPQNEIARAEALQLADTDHQYISGTAGNPLRGLIQDHLSVSVMLCSKDTFFDRRTYQQLIYAALRPESGHITGERIELVPPAIFKPVPRWTGKQVITTILKNIRPPDCGDLWMNSSAKIKSRSWGPDSMEGTVMFRDGEFISGILDKSQLGPSDGGFIHAVHEVYGPSVAGKLLSGMGRLLNRYLAMVAFTCGMDDLRMTPEGEKNRKEIIKAAANIGLEVAAKYVSLEDQKPTKDDPLLLERLEEVLRDDKKQEGLELLTNQACAKLSTAITEKCLPAGLEKQFPQNHMQSMTISGAKGSPVNANLISCNLGQQVLEGRRVPVMVSGKTLPSFKPFDTDVRAGGYIVNRFLTGIRPQEYYFHHMAGREGLIDTAVKTSRSGYLQRCLIKGMEGLRVAYDSTVRDSDGSVVQFLFGEDGIDISKQKYLNDFEFVLRNLDSQLPQIRYHEPGVQALFEHKDEVIKRMKSAIRSANSRDPLNPVQNELDPSTFGFATSEKFFAKMMEYVKNNKDGLIKEKGSKESKKGTISRKTAEKILAAKYIRSLVEPGEAVGIVAGQSIGEPSTQMTLNTFHLAGHSAKNVTLGIPRLREILMTASARISTPAMTLVVNEELSVEDAEKFAKSISALALMHVTNEAVVREEVGRGLGLPVAKKFHIRLRFFEAEEYTKMYAITIHDVLNTVERKFIPLLCSLTKKEIKKKLKEHSAATPEIGVKVGTVEMAPTGAERESGGDEDDDDDDVDDDATGAALKAKRSEAVSYGPNDDDDDAIQQQLQRETEDAEEGEEQLEFDDEAYGGSPEPEDGLGDQMDTIRSKTREDRIKNKNEHVARFRCDEKGGEWVEFWLEYEPTIPKILMLSLVQEAVKKSTIQQIPGIGSATFEPKYKKDPVTGEQVVVEKLVHTSGSNIRAMQQYGDYINPNRIQTNDIAQVLEVYGVEACRNNIVRELSSVFAGHGIAVDQRHLNLIADFMTRNGGFTPFNRIGLTHNVSPFTKMSYETTVGFLKDAVLDGDWDTLATPSSRLVVGKLGTMGTGSFDVLTRVPTEHRVTAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZX2</accession>
    <name>G0RZX2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0007940</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691324.1">
        <property type="nucleotide sequence ID" value="XM_006691261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZX2"/>
    <dbReference type="STRING" id="759272.G0RZX2"/>
    <dbReference type="GeneID" id="18254832"/>
    <dbReference type="KEGG" id="cthr:CTHT_0007940"/>
    <dbReference type="eggNOG" id="KOG1164">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019279_2_7_1"/>
    <dbReference type="OMA" id="IFDWTFL"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14125">
        <property type="entry name" value="STKc_CK1_delta_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000159">
        <property type="entry name" value="Casein kinase I hhp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="317"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="330"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS23133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="389" mass="44734" checksum="02AEC6B918110C92" modified="2011-10-19" version="1">MSSMVRSQEPPLDLRVGNKYRIGRKIGSGSFGDIYLGTNIISGEEIAIKLESVKAKHPQLEYEARVYKSLAGGVGIPFVRWFGTECDYNAMVLDLLGPSLEDLFNFCNRKFSLKTVLLLADQLISRIEYIHAKSFIHRDIKPDNFLMGIGKRGNQVNVIDFGLAKKYRDPKTHFHIPYRENKNLTGTARYASINTHLGVEQSRRDDMESLGYVMLYFCRGSLPWQGLKAATKKQKYDRIMEKKMTTPTDVLCRGFPNEFAIYLNYTRSLRFDDKPDYSYLRKIFRDLFVREGFQYDYVFDWTVYKYQKNAQAIAQAANNGNQNEDERQKQQQQQQAAKQAPAALPRATRKQITDTPDASRALPGSDRMLRSAARAQDPGMGYNKYRPME</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZZ4</accession>
    <name>G0RZZ4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Serine-type endopeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0008160</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691346.1">
        <property type="nucleotide sequence ID" value="XM_006691283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZZ4"/>
    <dbReference type="GeneID" id="18254854"/>
    <dbReference type="KEGG" id="cthr:CTHT_0008160"/>
    <dbReference type="eggNOG" id="KOG1153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011263_1_4_1"/>
    <dbReference type="OMA" id="RHPDVDY"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019863">
        <property type="term" value="F:IgE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.80:FF:000006">
        <property type="entry name" value="Autophagic serine protease Alp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000007">
        <property type="entry name" value="Subtilisin-like serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012949054" evidence="9">
        <location>
            <begin position="16"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="11">
        <location>
            <begin position="44"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="10">
        <location>
            <begin position="189"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS23155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="532" mass="57519" checksum="EA5C1DFFCD038586" modified="2011-10-19" version="1">MRGLFFLSLAAYAAAAPRAKVGTIDNDAAPILSSSNAEIVPNAYIIKFKKHVTPEVAAAHHTWIQEIHSAAETRRLDLKKRSQFPFVDQVFHGLKHTYQIGQEFLGYAGHFDDETIEQVRRHPDVEYIERDTIVHTMRFEEAKEECHGEIEKSAPWGLARISHRDTLTFSTFNKYLYAAEGGEGVDAYVIDTGTNIEHVDFEGRAKWGKTIPAGDADVDGNGHGTHCSGTIAGKKYGVAKKANIYAVKVLRSNGSGTMSDVVAGVEWVATQHLENVKLAKAGKRKGFKGSVANMSLGGGKTRTLDDTVNAAVAVGVHFAVAAGNDNADACNYSPAAAESAITVGASAIDDSRAYFSNYGKCTDIFAPGLSILSTWIGSKYATNTISGTSMASPHIAGLLAYYLSLQPSEDSEYSVAPITPKKMKENLLKIATEGALSDLPRDTPNLLAWNGGGCSNYSAIIEAGGYKVERKSQSSKIEIPTSFSDVEEELKSISKKVHEGASSFADRAKKFTEKIHKLVDEELKEFIEELGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0S031</accession>
    <name>G0S031_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0008550</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
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        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the WD repeat LST8 family.</text>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842">
        <property type="entry name" value="G BETA-LIKE PROTEIN GBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842:SF2">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G04300)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
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        <location>
            <begin position="695"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="167"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS23192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="931" mass="104295" checksum="8A06B6594FD146C8" modified="2011-10-19" version="1">MHPMQFGTRDAGRKPPLKRARVEGDITLAAACDSTANPSSSLPIDHFTQCLEKHVFPHVDAPISRLSAEEVNTLEIGKRVIAILTGPEFTKEYIKTGGNISPEFEAKLARRAEAEVQALSKQPTSSVRISTFLAEIAKRSRPSHFGSSFAAFSETTPTPALPYEASVQLRSHSKPASDKRSHQDLQKGSKDPRKDLMKVLRVNQQYVPVVVKAIAKTKRLPGRTESDLANLFQDLVAYGPRPKPETLKIERDHDDQHGDFVRSSRLNSLLFAREIWGQRGFVTMRTLENFNNDFRKCREDELERRAYWLGCAGDVVTISWVSNNSFICGTTDHSDSHNQQYNKPGNLVFGSCDSWTLQAYPDHRIVRPIVNDGENSTEDMVQSQSPWLYTSVVSSDFDHLHGLAFTSGFDRMVKIWRIDKAGTSMMVVGEWRHDGNVNFVVASKHPAGLVATAADVVADAVRIYTIDQDNISMSPFRSFSCSRVTDPDGSVVSTEKWAYFPATMQWGLEESVKHLLLVGYSPRSLTGNDMDIPEDRQKSGELCLWDGLTGKRWRITSATTQNVFEVLWHPTQPWFVAATTPLGLDVDPGVRTQIRIFRPIDLQDAGGPAFSPIWTLDCRALDINELTIMPNSTIFCYITAGCTDGCTYVWDTGQKSNRPIRILRHGDPVDEVPGDREKEDIGVKFTAWGTTLDRFYTASSDGVLKVWNIRSENNPHVRDLLRAPAAITAGMFSPDKSRLIIGDASGRVHLLSVNEQDERPATVLKLPGSDIVRIRQPTITLHPEPPPPTYDARGRPILSHSGVEIGRAYLENEYLERHPDPTIGVVQGPRYAKTGLFRREAHFLEDPSQPLLAHFEVHQQEANKGFSGRRREQFLSLRPVKEVEGLREKHARNKAMNFDINALDEETITGLLCEGADLELGEDYVLEYESE</sequence>
</entry>
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    <accession>G0S064</accession>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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    <dbReference type="STRING" id="759272.G0S064"/>
    <dbReference type="GeneID" id="18254927"/>
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    <dbReference type="HOGENOM" id="CLU_013114_0_0_1"/>
    <dbReference type="OMA" id="EEMHGYI"/>
    <dbReference type="OrthoDB" id="74178at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052602">
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    </dbReference>
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        <property type="entry name" value="TMF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022091">
        <property type="entry name" value="TMF_TATA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46515:SF1">
        <property type="entry name" value="TATA ELEMENT MODULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46515">
        <property type="entry name" value="TATA ELEMENT MODULATORY FACTOR TMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12329">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12325">
        <property type="entry name" value="TMF_TATA_bd"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TATA element modulatory factor 1 TATA binding" evidence="6">
        <location>
            <begin position="787"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="25"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="653"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="709"/>
            <end position="778"/>
        </location>
    </feature>
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        <location>
            <begin position="287"/>
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        </location>
    </feature>
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        <location>
            <begin position="800"/>
            <end position="900"/>
        </location>
    </feature>
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        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
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            <end position="106"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
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    <sequence length="903" mass="98665" checksum="FA2D5A9E8F316A2B" modified="2011-10-19" version="1">MATSRWGALLSQAVAGVEAKLDTLLADSDSSSSQQNESKPPTPSPAKQTPAAPRTSTSSSRANDRLQEKLARAMAAKGVGRGSLSAQASPRQSIDAPRRDSTDSIDRTGTLAKDLSKDTQSPRCSLDVTTKSSEDSAPSLEKALSEVRGKDFSSLPQEANGASSSTDAQPDAITSPPDTVPAAVASEPVPKPDIQSPPDSSTDEDLLKEDRQGSDESQRRHQEEIHSYVERIDALEAKLQFLAREATESARKAALAAPPGSLEKKLAEKDQQIAQLMEEGKNLASTEQNLRAALKKLRATVADNEKELNNLRTAKDKSEKEIEALRGRARRADELEKAQDDLQKRLEQAQKELNSLRPEIRSKDNLIAELRTQLQKATEQAEAISAKVNEQEREKDKRRIADLEEEVAALKVEKNLVADRAKAQAAELREKAERANERARALELELKAEVQLMEGKLEAMRIRAEEVSSSAAGDSQAKLLRQIETLQTQYSIASENWQGIETTLLARIAGLEKERDEAVQRESEMRKKAREAALRAKRQEEELEETRAKLPNIQEEVKSYQVQVSALKKRAEEAEAALAKATAEFEKQKQAWEVEREEQRQLQSSERPRSWLEELPSASFLKQAESRPDSPQLTVPQRAFSTDFLGIQNFSSSKLRKASAPPSEAGGMPFSLSSSRRPSAQPPGRPSITPQLGAGSSGVFSPVSLFFSPTSEAAPPNPLATAAAPTRGGADEAASSIFEGIERTTSPPPHNPTQTSTVTGTATTTGAGAGPATSAGTPQQTLQDMVSVSTVAAGPSVQLVERMSAAIRRLESEKIAAREELARISRQRDEARAEIVTLMREIEQGRAAAQRTAELEKELKDVRQRYETTLELLGEKSEEVEELKQDVADLKSMMRELVERTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0D7</accession>
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    <organism evidence="28">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
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        <lineage>
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            <taxon>Sordariomycetes</taxon>
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    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="29 30" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="476" last="476">
            <title>High-resolution structures of a thermophilic eukaryotic 80S ribosome reveal atomistic details of translocation.</title>
            <authorList>
                <person name="Kisonaite M."/>
                <person name="Wild K."/>
                <person name="Lapouge K."/>
                <person name="Ruppert T."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="35079002"/>
            <dbReference type="DOI" id="10.1038/s41467-022-27967-9"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.90 ANGSTROMS) OF 1-126</scope>
    </reference>
    <reference evidence="33 34 35" key="3">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e56910" last="e56910">
            <title>Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation during pre-60S biogenesis.</title>
            <authorList>
                <person name="Lau B."/>
                <person name="Huang Z."/>
                <person name="Kellner N."/>
                <person name="Niu S."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
                <person name="Cheng J."/>
            </authorList>
            <dbReference type="PubMed" id="37129998"/>
            <dbReference type="DOI" id="10.15252/embr.202356910"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <reference evidence="38 39 40" key="4">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e57984" last="e57984">
            <title>Structural insights into coordinating 5S RNP rotation with ITS2 pre-RNA processing during ribosome formation.</title>
            <authorList>
                <person name="Thoms M."/>
                <person name="Lau B."/>
                <person name="Cheng J."/>
                <person name="Fromm L."/>
                <person name="Denk T."/>
                <person name="Kellner N."/>
                <person name="Flemming D."/>
                <person name="Fischer P."/>
                <person name="Falquet L."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="37921038"/>
            <dbReference type="DOI" id="10.15252/embr.202357984"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.12 ANGSTROMS)</scope>
    </reference>
    <reference evidence="31 32" key="5">
        <citation type="journal article" date="2023" name="Nat. Struct. Mol. Biol." volume="30" first="670" last="677">
            <title>Structural inventory of cotranslational protein folding by the eukaryotic RAC complex.</title>
            <authorList>
                <person name="Kisonaite M."/>
                <person name="Wild K."/>
                <person name="Lapouge K."/>
                <person name="Gese G.V."/>
                <person name="Kellner N."/>
                <person name="Hurt E."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="37081320"/>
            <dbReference type="DOI" id="10.1038/s41594-023-00973-1"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.20 ANGSTROMS) OF 1-126</scope>
    </reference>
    <reference evidence="36 37" key="6">
        <citation type="journal article" date="2024" name="Nat. Commun." volume="15" first="716" last="716">
            <title>Methionine aminopeptidase 2 and its autoproteolysis product have different binding sites on the ribosome.</title>
            <authorList>
                <person name="Klein M.A."/>
                <person name="Wild K."/>
                <person name="Kisonaite M."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="38267453"/>
            <dbReference type="DOI" id="10.1038/s41467-024-44862-7"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.94 ANGSTROMS)</scope>
    </reference>
    <comment type="function">
        <text evidence="21">Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a di-trans,poly-cis-dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = N(4)-(oligosaccharide-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + a di-trans,poly-cis-dolichyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22980"/>
            <dbReference type="Rhea" id="RHEA-COMP:12804"/>
            <dbReference type="Rhea" id="RHEA-COMP:12805"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="Rhea" id="RHEA-COMP:19509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50347"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57570"/>
            <dbReference type="ChEBI" id="CHEBI:132529"/>
            <dbReference type="EC" id="2.4.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the STT3 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.18" evidence="7"/>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691489.1">
        <property type="nucleotide sequence ID" value="XM_006691426.1"/>
    </dbReference>
    <dbReference type="PDB" id="7OLC">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="Lh=1-126"/>
    </dbReference>
    <dbReference type="PDB" id="7OLD">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="Lh=1-126"/>
    </dbReference>
    <dbReference type="PDB" id="7Z3N">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="Lh=1-126"/>
    </dbReference>
    <dbReference type="PDB" id="7Z3O">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.30 A"/>
        <property type="chains" value="Lh=1-126"/>
    </dbReference>
    <dbReference type="PDB" id="8I9P">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="Lh=1-935"/>
    </dbReference>
    <dbReference type="PDB" id="8I9R">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="Lh=1-935"/>
    </dbReference>
    <dbReference type="PDB" id="8I9T">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.60 A"/>
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    </dbReference>
    <dbReference type="PDB" id="8I9V">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="Lh=1-935"/>
    </dbReference>
    <dbReference type="PDB" id="8I9W">
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        <property type="resolution" value="3.10 A"/>
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    <dbReference type="PDB" id="8I9X">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="Lh=1-935"/>
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    <dbReference type="PDB" id="8I9Y">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
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    <dbReference type="PDB" id="8I9Z">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
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    <dbReference type="PDB" id="8IA0">
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    <dbReference type="PDB" id="8ONZ">
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        <property type="resolution" value="2.94 A"/>
        <property type="chains" value="Lh=1-935"/>
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    <dbReference type="PDB" id="8OO0">
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    <dbReference type="PDB" id="8PV1">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.56 A"/>
        <property type="chains" value="Lh=1-935"/>
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    <dbReference type="PDB" id="8PV2">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.63 A"/>
        <property type="chains" value="Lh=1-935"/>
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    <dbReference type="PDB" id="8PV3">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="Lh=1-935"/>
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    <dbReference type="PDB" id="8PV4">
        <property type="method" value="EM"/>
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    <dbReference type="PDB" id="8PV5">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.86 A"/>
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    <dbReference type="PDB" id="8PV6">
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        <property type="resolution" value="2.94 A"/>
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        <property type="resolution" value="2.12 A"/>
        <property type="chains" value="Lh=1-935"/>
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    <dbReference type="PDB" id="8PV8">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.91 A"/>
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    <dbReference type="PDB" id="8PVK">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.55 A"/>
        <property type="chains" value="Lh=1-935"/>
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    <dbReference type="PDB" id="8PVL">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.19 A"/>
        <property type="chains" value="Lh=1-935"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0D7"/>
    <dbReference type="EMDB" id="EMD-12976"/>
    <dbReference type="EMDB" id="EMD-12977"/>
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    <dbReference type="EMDB" id="EMD-17950"/>
    <dbReference type="EMDB" id="EMD-17951"/>
    <dbReference type="EMDB" id="EMD-17952"/>
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    <dbReference type="EMDB" id="EMD-17954"/>
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    <dbReference type="EMDB" id="EMD-17956"/>
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    <dbReference type="EMDB" id="EMD-17969"/>
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    <dbReference type="EMDB" id="EMD-35279"/>
    <dbReference type="EMDB" id="EMD-35281"/>
    <dbReference type="EMDB" id="EMD-35283"/>
    <dbReference type="EMDB" id="EMD-35285"/>
    <dbReference type="EMDB" id="EMD-35286"/>
    <dbReference type="EMDB" id="EMD-35287"/>
    <dbReference type="EMDB" id="EMD-35288"/>
    <dbReference type="EMDB" id="EMD-35289"/>
    <dbReference type="EMDB" id="EMD-35290"/>
    <dbReference type="SMR" id="G0S0D7"/>
    <dbReference type="STRING" id="759272.G0S0D7"/>
    <dbReference type="GeneID" id="18255003"/>
    <dbReference type="KEGG" id="cthr:CTHT_0009650"/>
    <dbReference type="eggNOG" id="KOG2292">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3436">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009279_1_0_1"/>
    <dbReference type="OMA" id="TWYAIGT"/>
    <dbReference type="OrthoDB" id="10261066at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004579">
        <property type="term" value="F:dolichyl-diphosphooligosaccharide-protein glycotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043687">
        <property type="term" value="P:post-translational protein modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00427">
        <property type="entry name" value="Ribosomal_L29_HIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.310:FF:000002">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3450:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12610:FF:000001">
        <property type="entry name" value="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_uL29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_uL29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_uL29_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048999">
        <property type="entry name" value="STT3-PglB_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048307">
        <property type="entry name" value="STT3_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02516">
        <property type="entry name" value="STT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21436">
        <property type="entry name" value="STT3-PglB_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="Ribosomal protein L29 (L29p)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="29 30 31" id="KW-0002">3D-structure</keyword>
    <keyword evidence="12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="18" id="KW-0464">Manganese</keyword>
    <keyword evidence="16 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="14 27" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 24" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="282"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="366"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="464"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="494"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="555"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="582"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="Oligosaccharyl transferase STT3 N-terminal" evidence="25">
        <location>
            <begin position="213"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="STT3/PglB/AglB core" evidence="26">
        <location>
            <begin position="729"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="912"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="917"/>
            <end position="935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00059243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00067960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF02516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF21436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="EGS23298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="29">
        <source>
            <dbReference type="PDB" id="7OLC"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="30">
        <source>
            <dbReference type="PDB" id="7OLD"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="31">
        <source>
            <dbReference type="PDB" id="7Z3N"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="32">
        <source>
            <dbReference type="PDB" id="7Z3O"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="33">
        <source>
            <dbReference type="PDB" id="8I9P"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="34">
        <source>
            <dbReference type="PDB" id="8I9R"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="35">
        <source>
            <dbReference type="PDB" id="8I9T"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="36">
        <source>
            <dbReference type="PDB" id="8ONZ"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="37">
        <source>
            <dbReference type="PDB" id="8OO0"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="38">
        <source>
            <dbReference type="PDB" id="8PV1"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="39">
        <source>
            <dbReference type="PDB" id="8PV2"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="40">
        <source>
            <dbReference type="PDB" id="8PV3"/>
        </source>
    </evidence>
    <sequence length="935" mass="105043" checksum="B196DAD0F844D7D4" modified="2011-10-19" version="1">MSSNGKVKAGQLWSKNKEELTKILGELKTELSQLRIQKISSSGAKLNKIHDLRKSIARVLTVINAKQRAQLRLFYKNKKYLPLDLRPKLTRALRRRLSKEDASRVLEKTKKRLTHFPQRKYAVKAATYSEGPALSIYHSHQREARCSLVQCCTFEPELRESLLLLPVAASLKGPNFTRRERQHRNPSEATMSAAEPLKLLASAGKGKSTRSVLRVAILVLIAGAAVASRLFSVIRFESIIHEFDPWFNFRATKYLVANGFYKFWDWFDDRTWHPLGRVTGGTLYPGLMVTSGVIYHLLRFLTVPVDIRNICVLLAPGFSGLTAIAAYLLTNEMTTSPSAGLLAAAFMGIAPGYISRSVAGSYDNEAIAIFLLVFTFFLWIKALKQGSMLWGALCALFYGYMVASWGGYAFITCLLPLHSFVLICMGRYSTRLYVAYTTWYALGTLASMQIPFVGFLPVKTSEHMPALGIFGFLQLLAFLDYVRSTISSRQFQTFLWLFAGGIFGLGLLGLVIATSAGLIAPWSGRFYSLWDTGYAKIHIPIIASVSEHQPTAWPAFFFDLNMLVWLFPVGVYLCFQQLGDEHVFIIVYALFGSYFAGVMVRLMLTLTPVVCVAAAIAFSSLLDTYLNLKTPNPGQAQATEDAGKKKSGLKAASKPAVGVYALWGKTMMISGLTIYLLLFVLHCTWVTSNAYSSPSVVLASRLPDGSQHIIDDYREAYQWLRQNTREDAKIMSWWDYGYQIGGMADRPTLVDNNTWNNTHIATVGKAMASREEVSYPIMRQHEVDYVLVVFGGLLGYSGDDINKFLWMVRIAEGIWPDEVSERAFFTPRGEYRVDAEATDTMKNSLMYKMCYYNYNNLFPPGQAVDRMRGVRLPEVGPTLNTLEEAFTSENWIIRIYKVKDLDNLGRDHASAAAFERGHKKKKATKKRGPRVLRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0E5</accession>
    <name>G0S0E5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein l9-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0009740</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="476" last="476">
            <title>High-resolution structures of a thermophilic eukaryotic 80S ribosome reveal atomistic details of translocation.</title>
            <authorList>
                <person name="Kisonaite M."/>
                <person name="Wild K."/>
                <person name="Lapouge K."/>
                <person name="Ruppert T."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="35079002"/>
            <dbReference type="DOI" id="10.1038/s41467-022-27967-9"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.90 ANGSTROMS)</scope>
    </reference>
    <reference evidence="9 10 11" key="3">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e56910" last="e56910">
            <title>Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation during pre-60S biogenesis.</title>
            <authorList>
                <person name="Lau B."/>
                <person name="Huang Z."/>
                <person name="Kellner N."/>
                <person name="Niu S."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
                <person name="Cheng J."/>
            </authorList>
            <dbReference type="PubMed" id="37129998"/>
            <dbReference type="DOI" id="10.15252/embr.202356910"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e57984" last="e57984">
            <title>Structural insights into coordinating 5S RNP rotation with ITS2 pre-RNA processing during ribosome formation.</title>
            <authorList>
                <person name="Thoms M."/>
                <person name="Lau B."/>
                <person name="Cheng J."/>
                <person name="Fromm L."/>
                <person name="Denk T."/>
                <person name="Kellner N."/>
                <person name="Flemming D."/>
                <person name="Fischer P."/>
                <person name="Falquet L."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="37921038"/>
            <dbReference type="DOI" id="10.15252/embr.202357984"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.91 ANGSTROMS)</scope>
    </reference>
    <reference evidence="12" key="5">
        <citation type="journal article" date="2024" name="Nat. Commun." volume="15" first="716" last="716">
            <title>Methionine aminopeptidase 2 and its autoproteolysis product have different binding sites on the ribosome.</title>
            <authorList>
                <person name="Klein M.A."/>
                <person name="Wild K."/>
                <person name="Kisonaite M."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="38267453"/>
            <dbReference type="DOI" id="10.1038/s41467-024-44862-7"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.10 ANGSTROMS)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691497.1">
        <property type="nucleotide sequence ID" value="XM_006691434.1"/>
    </dbReference>
    <dbReference type="PDB" id="7OLC">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="LH=1-229"/>
    </dbReference>
    <dbReference type="PDB" id="7OLD">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="LH=1-229"/>
    </dbReference>
    <dbReference type="PDB" id="8I9T">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.60 A"/>
        <property type="chains" value="LH=1-229"/>
    </dbReference>
    <dbReference type="PDB" id="8I9V">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="LH=1-229"/>
    </dbReference>
    <dbReference type="PDB" id="8I9W">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="LH=1-229"/>
    </dbReference>
    <dbReference type="PDB" id="8I9X">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="LH=1-229"/>
    </dbReference>
    <dbReference type="PDB" id="8I9Y">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="LH=1-229"/>
    </dbReference>
    <dbReference type="PDB" id="8I9Z">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="LH=1-229"/>
    </dbReference>
    <dbReference type="PDB" id="8IA0">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="LH=1-229"/>
    </dbReference>
    <dbReference type="PDB" id="8OO0">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="LH=1-229"/>
    </dbReference>
    <dbReference type="PDB" id="8PV8">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.91 A"/>
        <property type="chains" value="LH=1-229"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0E5"/>
    <dbReference type="EMDB" id="EMD-12976"/>
    <dbReference type="EMDB" id="EMD-12977"/>
    <dbReference type="EMDB" id="EMD-17004"/>
    <dbReference type="EMDB" id="EMD-17957"/>
    <dbReference type="EMDB" id="EMD-35283"/>
    <dbReference type="EMDB" id="EMD-35285"/>
    <dbReference type="EMDB" id="EMD-35286"/>
    <dbReference type="EMDB" id="EMD-35287"/>
    <dbReference type="EMDB" id="EMD-35288"/>
    <dbReference type="EMDB" id="EMD-35289"/>
    <dbReference type="EMDB" id="EMD-35290"/>
    <dbReference type="SMR" id="G0S0E5"/>
    <dbReference type="STRING" id="759272.G0S0E5"/>
    <dbReference type="GeneID" id="18255012"/>
    <dbReference type="KEGG" id="cthr:CTHT_0009740"/>
    <dbReference type="eggNOG" id="KOG3255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065464_0_0_1"/>
    <dbReference type="OMA" id="YAHFPMK"/>
    <dbReference type="OrthoDB" id="10252633at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000003">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000004">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002359">
        <property type="entry name" value="Ribosomal_uL6_CS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF16">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00700">
        <property type="entry name" value="RIBOSOMAL_L6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7 8 9" id="KW-0002">3D-structure</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="52"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="134"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS23306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="7OLC"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="7OLD"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="8I9T"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="8I9V"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="8I9W"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="8OO0"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="8PV8"/>
        </source>
    </evidence>
    <sequence length="229" mass="25836" checksum="BACE14DFA82C14BC" modified="2011-10-19" version="1">MRYIHSEETIPVPENGTFRKFRRNDYTFGRTRGREKKRGTTSSKIGELDINGLKVSIKSRLVTVEGPRGKLQKDLSHIAVNFSVVKKGVIGLEIHHGSRKDVAALRTVRTIINNMIIGVTKGFKYKMRYVYAHFPINVNVEKNAETGCYEVEIRNFIGEKIVRKVVMAPGVEVEISKAQKDELILSGNSLEAVSQSAADIQQICKVRNKDIRKFLDGIYVSEKGNIVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G0S124</accession>
    <name>G0S124_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SANT SWI3, ADA2, N-coR and TFIIIB'' DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0012090</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691726.1">
        <property type="nucleotide sequence ID" value="XM_006691663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S124"/>
    <dbReference type="STRING" id="759272.G0S124"/>
    <dbReference type="GeneID" id="18255247"/>
    <dbReference type="KEGG" id="cthr:CTHT_0012090"/>
    <dbReference type="eggNOG" id="ENOG502SFIP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_353803_0_0_1"/>
    <dbReference type="OMA" id="QVCDDII"/>
    <dbReference type="OrthoDB" id="5398572at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051144">
        <property type="entry name" value="Formin_homology_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45733">
        <property type="entry name" value="FORMIN-J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45733:SF8">
        <property type="entry name" value="FORMIN-J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="735"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="529"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="575"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="738"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="788"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="798"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="817"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="831" mass="92032" checksum="B99017E3B348AAA5" modified="2011-10-19" version="1">MSGRGRGRPPSRSADPAPAPVPGRRSTRQQQQHAAQPQQEVGDLQQHSQPELLLHEKQQEQPQSQTEPSMSEMKFNNNIDPAITGPSSESAMPPPPAPGFKSSQGQSGFGIPRRGTRRDLSAPSMVSVNSIANTDSFSQAELPSTAPQKDHLFSHPARTASVLSSQSSQLGDASRQRTARVRLMQRMRHRLRGACDDFFNFLSTAPIEDDLWLDEKEAFKAPLESYLRHFLSDVESPSVDPSYVLNALGLDKSSPEGRVVYMEMLMANLTLLFDDLQPQPQSLMAVLQKLEQNFPGAYVPDDPEFHDARTNEQLANQTLLIRTQQCIYKLQRRCGENAAPFNPLQVVAEQWCDGDFSLEAVKAFVRDRNKDAFQLKPLTVADSEDTKERNTARFASICRLLPDTEVQGSLLDLKELQGTYSVEEFIGHSIEFIKTIYDKINISISQATSLIPAPAEVDSRAGSQIHHHLETESITGFHRQESQATPSVPYDMDLLRRMKQLEQRPESTPYPDSHQLPPTPYQPPPRLPYAPGFSSPSSYSGPQHTSSFQPNGSLYTESAAQATGRKRRAQHDAPAEGAAGAVAPPAKKPRGKRKKNDAQASAGEEAVMAPATQSQYPPVPDATDQDTVLDIVQQRTREMSAAARKAKKPQERKAWVRSDVRALIKAIEIYSCKWALIEKKIKDGTIHFERPRDQQALRDKARLLKQDYLKADMVLPPGFDLVVLGKKEKENVIAVGKNPERKESDVDENGKPINTEYRGDPGELLLANQEEQEQIEAPALPPPPPGEVPAGSSAQYPPVEPQPQPQPQPQPQPQPQPQQQAPLAQMDAPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0S135</accession>
    <name>G0S135_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0012200</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691737.1">
        <property type="nucleotide sequence ID" value="XM_006691674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S135"/>
    <dbReference type="STRING" id="759272.G0S135"/>
    <dbReference type="GeneID" id="18255258"/>
    <dbReference type="KEGG" id="cthr:CTHT_0012200"/>
    <dbReference type="eggNOG" id="ENOG502S4E9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011385_0_0_1"/>
    <dbReference type="OMA" id="FVCLRCE"/>
    <dbReference type="OrthoDB" id="5392646at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048401">
        <property type="entry name" value="SLS1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032741">
        <property type="entry name" value="Sls1_KH-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048748">
        <property type="entry name" value="SLS1_KH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048400">
        <property type="entry name" value="SLS1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14611">
        <property type="entry name" value="KH_SLS1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20777">
        <property type="entry name" value="KH_SLS1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20778">
        <property type="entry name" value="SLS1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20776">
        <property type="entry name" value="SLS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLS1 N-terminal" evidence="3">
        <location>
            <begin position="232"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="SLS1 first KH" evidence="2">
        <location>
            <begin position="355"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="SLS1 second KH" evidence="4">
        <location>
            <begin position="429"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="SLS1 C-terminal" evidence="5">
        <location>
            <begin position="526"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="852"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS22745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="933" mass="104949" checksum="7B33AB972F500A69" modified="2011-10-19" version="1">MLRRTLAGSASFVCLRCRLRLTGAANRLRLPPPALPSSAFGGARRYIGTRDVPAASEEAGSQSEPQSTPQTPQTSQTPPAEQPAQTEGTSTTEPTKSTKEPIAPIEPTIQLDQTSQLEQSGRTEQPKQAAYNEPGEPSTEPFVLPEGYLEEDPLLKPKRFKKPKKYKARTRILAPERAGLPIDILGQPGAAIILKEEKRIRRKNFEDIQADEGTENKVDPTTLLPNEASGDPALQDILLNIHELKPKDREVLTEAEFMELKKTLMNGFTSAQLVDYIQEYLETRKLLASEEQAPERPPWLLELRPWVPAVENAIQDVDPQLDGYITASMTPKERLAIRLMRQCWNLSYQEIQQRPGYLIFRLRKVEFTLLTRGNKRWLEGAPRAILRTVNQVRMIRESQHISIMAPKYAAEVILDRVNRILSNTRTAEFNATHVCAPEALVPAVLEEVGSVTNTVVRYDRSGEKIAVSWTHNPDRPEDLETADQTVLRFLRDAYGVKPREASSLEVIPQNLENNGRYVTVLDCGKKLSWQQRSKIWGRWTTPVPLASESSAKPDQPLNIPEKALRFAWDAVNAKSSEQESTTKSPDGWSSHLRTDTSAVFGQVVFAQKQAMLQKSSAPGATQLDRSLERAFVPFLPPLGTLDLPTNLREEGLWHTTIVIRFVPSPTLSPDLLESAPNLELRIEADHREIKRLKDLRAVTDIFTNDVLFPSAAVDTRLVQQRYFVLPGEQIENHATPIIDFLGKANLRPWDGKLITPTFVPKIRLPRRVFSPVDSSNDAATPKQQASSGEEGFIELDYNLASVEMQRTVTAEYLGLKLRYTSIQAGQRGGERAELSLEAVRITPEELDRLKQEEEARRRAQRQAKAREENLDDEEDGEGTIHRSKFERHVLNDPTRALSPITGPPAAVREFLDTVVRIAEGEDRLKWQLKTPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1N9</accession>
    <name>G0S1N9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative sister chromatid cohesion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0014280</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691941.1">
        <property type="nucleotide sequence ID" value="XM_006691878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1N9"/>
    <dbReference type="STRING" id="759272.G0S1N9"/>
    <dbReference type="GeneID" id="18255466"/>
    <dbReference type="KEGG" id="cthr:CTHT_0014280"/>
    <dbReference type="eggNOG" id="KOG1213">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025342_0_0_1"/>
    <dbReference type="OMA" id="QQCHYVL"/>
    <dbReference type="OrthoDB" id="5427633at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030892">
        <property type="term" value="C:mitotic cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21789">
        <property type="entry name" value="Rad21_Rec8_M_SpRec8p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039781">
        <property type="entry name" value="Rad21/Rec8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585:SF70">
        <property type="entry name" value="RAD21_REC8 N TERMINAL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G02900)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585">
        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="189"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="296"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="489"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="296"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="454"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="511"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS22949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="719" mass="78910" checksum="233720A3F1DD83FD" modified="2011-10-19" version="1">MFYSHEILTNHQYGVATVWLVSTIGLRSSTRKITRKAIQEVNVKKACETILQPDAPMALRLQGRLLYGLSRVYSQQCHYVLTDAEKVQAHMMAFWTSLRNCDDSLDPEAGKSKRKELILEDDPNFDLNINLPALDFDEDGNPVALQLSQTSRKTSSQLSPLQSNDSIRSFHRSPISGFNLSQSISPGLSGNSLLPDPLDQDSMTPNKSNDGLLPFDGEERHLHAVEDVGIIIDADGNAMEMEPPEVLHQSSLEAQEEGVFLNQPEENLLFDQQGDALIGRSDVLVMHSHPVRLERPVEQERQEPEQVRQEVAVEGVNSSQPPVRSQRRRRRPMLTPDDQTKITRQELKSWSADYLTNAERAIRPRNAVTPAEARRNAFNLIFGRGIGGVGFPTGVPGLIHPLADQFAGLGLQVSLLGVAIIPNNAVRGRRRTALEALELEEDEHGRRVRPRLSAESNSDADQAAQQLPRHDEDAAGLLVNDDEFPPIELGRRAGSVLGSDNNPPSDLPWNRPSSQVPSSSIKAGSRAGSRQVSASPLHHRGAMVVPGPDIERYSDQAVFGTGDFAPVLHSGAPGISSSPPRLAFEQDFFHHYHEHGEVSGAASQVLYSALDSDGRKFLEYLVSLAREWGVRVAGDELVIGAGRKHRCKWITFDELFPDEASRTCTAAAQAFHHVLTLATKNLICVAQEGQGGQVPFGTIRIGVEVPLDVHPAGAHDGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1R6</accession>
    <name>G0S1R6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8035 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0014550</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021705_2_0_1"/>
    <dbReference type="OMA" id="DFFYVME"/>
    <dbReference type="OrthoDB" id="5410752at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058348">
        <property type="entry name" value="DUF8035"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26118">
        <property type="entry name" value="DUF8035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8035" evidence="2">
        <location>
            <begin position="426"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="349"/>
            <end position="358"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="562" mass="66416" checksum="7A8A1572639018DD" modified="2011-10-19" version="1">MSARSRVDEYGYIREPRRAREYEERRYEIRERSRSRDRVPYFLREENRRPEQGPLVLREREREIVERPVRGRSPTPVRVHERVIERTRSVTPPPRPPSRRDGREEVRIRQVVRESSRGPGPERIRFIDSHSRSPSPVERERIRIVEKERAPNPPPSPRPTTPQVIQGPIIERQVITHYRDIDHGIVPAHPPSPLREHRDTEIEIHTSRGGTEVGIHRARSRSRVRGRSIERPVIRVDDDASVRVDRKHLHVDIERRRSLSRTGGRRAHSAAPPIIDHSSSSSDEEYEITSRIGARSRPGEAIGGSTRNWTIIDVPPGTERVRMDGAGGASAEVTWSKYSGVRRTRWIPDRDEEKDKDSIVSSTTTTTTVSERERGRVRSRSRDRRVSVSINLDKNDDRRELEVEKVTDRRIVRASSTNPPAKRQPETWTEITKDLVCREAIEQLGYEYEETDWFYYIVEYLSYDEVCQLVDLSDRIRAERQQRARELAWERGEWRPVDDWDLYYYRDHEDRHRGRDRHSRRHHHKYRYASSTVDYDDDGDSRVVEREVVYDSHRSRSRGYRH</sequence>
</entry>
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    <accession>G0S1V8</accession>
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    </protein>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="759272.G0S1V8"/>
    <dbReference type="GeneID" id="18255538"/>
    <dbReference type="KEGG" id="cthr:CTHT_0015000"/>
    <dbReference type="eggNOG" id="ENOG502QQ6D">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043181_7_2_1"/>
    <dbReference type="OMA" id="TNCVCIA"/>
    <dbReference type="OrthoDB" id="430315at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.110.10">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001938">
        <property type="entry name" value="Thaumatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31048">
        <property type="entry name" value="OS03G0233200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00314">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00347">
        <property type="entry name" value="THAUMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00205">
        <property type="entry name" value="THN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49870">
        <property type="entry name" value="Osmotin, thaumatin-like protein"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51367">
        <property type="entry name" value="THAUMATIN_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
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    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409217" description="Osmotin, thaumatin-like protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="434"/>
            <end position="451"/>
        </location>
    </feature>
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            <begin position="238"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS23018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="48181" checksum="8935EA7009C3FFC7" modified="2011-10-19" version="1">MATGIFVSVIAIFSTKTTALQHNLGQLNFDLDFSNIVDVNDPIPSIPSGVGTDKLNFTKSHHPHVNITKSQRPPDLRPIPLVVTNNCDETIWPGLATQNGLGPTVGGFELAPGKSKKLYVSADWQGRVWGRTNCSFNDDGSGPRVKGGLDGNGKACLTGDCNGRVDCRGPGQVPATLAEFNLLGGINNRQTFYDISLVDGYNLPIGLNYLPAPNTTWLPSRLTNCACIASPGYLSDPPTSPPLPSFNTSSSPTSTPEQPPYESTQTNPSLATWCPWPLQLNPPTTPPDEVYPYPETDSLQRPAFDPCLSACSATRSEKDCCVGPQYGSPETCKPGQYSIAAKKVCPDAYSYAYDDRESTFVVPAGGGWEVKFCPRGGRSTRILEVWGSEMRKMAAIAAGADPNSVDGGLKGNVGVGWGGWRAFVGWQSHAGRGAVAWGMVIGFVGIVVVLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0S217</accession>
    <name>G0S217_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0015640</name>
    </gene>
    <organism evidence="4">
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        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006692006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S217"/>
    <dbReference type="STRING" id="759272.G0S217"/>
    <dbReference type="GeneID" id="18255602"/>
    <dbReference type="KEGG" id="cthr:CTHT_0015640"/>
    <dbReference type="eggNOG" id="ENOG502RS6K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_769531_0_0_1"/>
    <dbReference type="OMA" id="MAFVEHI"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="314"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="283"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="177"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="426" mass="46550" checksum="EF90805B413FBB74" modified="2011-10-19" version="1">MGLATPTAPLRRLLAFIREVCPEIVHQTDVYGRTFIHRAYSIVRNREPLAALLVPFNTHLSSRRDAFGFNPLSQNKAESVFLPPRRAGGFQVSTQREELGPFRSTSRPPSSSEDDSFVAYHARLVEVIWSSYNNPRIEDSEGRNGLHCLAEAIINPQTMDRHMQRPNLKRKLSTKDITVSTSPPTTASTSSQRPPPSSSNPGPTITTPIPFTAATADEGTLSTRLRHLHSLLDPTVGVDPTHYDRFGTTPLMAFVEHIPDHHDDKAKTLQTLLETLVGRSTLGFPSPNMNNTSDTSSHPAAPGPSPILEARNRRGETALLVAARLGRKVALATLLELGANVGVRDVEGRGVLEVIDDEIGSARARADVCLYARLEACRALLTGRREWGVRYQRGRGVEGSVGLVQGGSVEGADRGAGVCEEWRVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>G0S247</accession>
    <name>G0S247_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0015960</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS23107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692099.1">
        <property type="nucleotide sequence ID" value="XM_006692036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S247"/>
    <dbReference type="GeneID" id="18255634"/>
    <dbReference type="KEGG" id="cthr:CTHT_0015960"/>
    <dbReference type="HOGENOM" id="CLU_1427819_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="190" mass="20841" checksum="818A54DA5B6E18E3" modified="2011-10-19" version="1">MVRSPSDLPNSVLAIYAVEGGDVFPSSWRQHNQSQDGNNGGEACHETLQAPRGTRITLDYLHSGPVYRVPRSPWTQSTYTLAFVASARFRVGVPGLHDMIDDTDTDSHEYQKYYGSFQNAELETPCRVESNVSAPSMSCQIHLAQAAQPAAALRRELKLALSLADEHSRRASPSGLLASRTTPTSVRLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0S278</accession>
    <name>G0S278_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Carrier protein (Ymc1)-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0016270</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692130.1">
        <property type="nucleotide sequence ID" value="XM_006692067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S278"/>
    <dbReference type="GeneID" id="18255665"/>
    <dbReference type="KEGG" id="cthr:CTHT_0016270"/>
    <dbReference type="eggNOG" id="KOG0758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_16_2_1"/>
    <dbReference type="OMA" id="VWFLAFE"/>
    <dbReference type="OrthoDB" id="409586at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF12">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="15"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="109"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="210"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS22111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="300" mass="32749" checksum="FD0D28D949CE0E47" modified="2011-10-19" version="1">MAEAEVQQSSALQTAKDLFSGAAGGVAQVLIGQPFDIVKVRLQTSSTYPSALSAAASIYKHEGPLAFYKGTLTPLLGIGACVSIQFGAFHAARRWLEQRREAKGQTKQLGYGEYYIAGAFAGIANTVLSSPIEHVRIRLQTQPHGEKRLYNGPWDCVRKLVAQGGVGNGLYRGTAVTLLREAQAYGVWFLVFEYLMNADAARNGVDRKDIASYKVALYGGLAGEALWLASYPFDVIKSRMQTDGFGQGKQFVNMRDCFRQTWREAGWKGFWKGIGPTLARAMPVSAGTFAVVEMTMRAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2F7</accession>
    <name>G0S2F7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0017070</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692209.1">
        <property type="nucleotide sequence ID" value="XM_006692146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2F7"/>
    <dbReference type="STRING" id="759272.G0S2F7"/>
    <dbReference type="GeneID" id="18255745"/>
    <dbReference type="KEGG" id="cthr:CTHT_0017070"/>
    <dbReference type="eggNOG" id="ENOG502QQI5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_885664_0_0_1"/>
    <dbReference type="OrthoDB" id="3469466at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004612">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001272">
        <property type="entry name" value="PEP_carboxykinase_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01293">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53795">
        <property type="entry name" value="PEP carboxykinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="56"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="314" mass="36445" checksum="7A005A10AEC65EBC" modified="2011-10-19" version="1">MTPRPLFLDSIDGVEQHVTIPDWNQPGKMRTVPIKLFNNAYLKYESVNGLPFASWPQFSSLPTELRIKIWRSTLERYRMIDLVIYPAIQEPEDFDAASDTRSYTKRNELGRIISGDGYWLRLGYGQHPTVPSPLFAVNHEAREVALSFYRVRLPLPHPDGVDILYLNPDYDIIYLQQDWSGPPLSKTQHYRLFVAFLHDVKAYDPLDQGIAHLALKEHHWHFFPGYHFEKDPATDQERCPLKSTRAILDAIHSGELAKVEHETYDFFNLQVPKTWPGVPLELLNPKNAWTTGAQSFETEVWKLGKLFLENFKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2J4</accession>
    <name>G0S2J4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0017440</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692246.1">
        <property type="nucleotide sequence ID" value="XM_006692183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2J4"/>
    <dbReference type="STRING" id="759272.G0S2J4"/>
    <dbReference type="GeneID" id="18255782"/>
    <dbReference type="KEGG" id="cthr:CTHT_0017440"/>
    <dbReference type="eggNOG" id="ENOG502SKGP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064110_0_0_1"/>
    <dbReference type="OMA" id="GWLIWRV"/>
    <dbReference type="OrthoDB" id="5421757at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="365" mass="41619" checksum="96A5514F0D68A39B" modified="2011-10-19" version="1">MTQTAKPKGGARLSGTSKSTTSSKSLPHPFIPAPKALSPFTDTLPKSSTTVYITHIDPRPATFKRNIFLVPISVNIAVVALFCWRMWVIAPYYFFLLASMLGYENHTTIRAADLAWGELARVIGRRTLTFMIDFLLAIFVWPWPYEFVFGASAGEAAGRGSPALWRWKVGFREKEVYVRRSRSSWSKVLEGRDILDRDGKENREAREAVIKRVREATQPMILQRKTGYVTMDGEWDLDWKAMVDATKLVDKKEIELEEFGTVALLWHEEHGWISIDLGQGDTKQQEQRRKQLEAFRKALAALDKEELFFRWVEMIQFETTQPGGFTPERQVAAAKKVRDMFHEHGVDFDGLWKEAVGTDGLAGMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2K2</accession>
    <name>G0S2K2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Redoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0017520</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692254.1">
        <property type="nucleotide sequence ID" value="XM_006692191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2K2"/>
    <dbReference type="STRING" id="759272.G0S2K2"/>
    <dbReference type="GeneID" id="18255790"/>
    <dbReference type="KEGG" id="cthr:CTHT_0017520"/>
    <dbReference type="eggNOG" id="KOG0541">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072440_3_0_1"/>
    <dbReference type="OMA" id="SAWGKQH"/>
    <dbReference type="OrthoDB" id="1882547at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000159">
        <property type="entry name" value="Peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430:SF39">
        <property type="entry name" value="PEROXISOMAL MEMBRANE ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5 7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Redoxin" evidence="8">
        <location>
            <begin position="43"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="6">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR637944-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS22235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="206" mass="22221" checksum="421536AA88DB2243" modified="2011-10-19" version="1">MIRPTAFRTLATAARVTARVPVVRAAPPRISHTFHTTARAFVKVGDPLPDTDALMEGSPGQRVNLAEEAQKVNNMLIIGVPAAYSPGCSTTHIPGYLNHPKTREFDMVAVVSVNDVFVMKAWGDSLDPSGDVGIRFLADPTGRFTRMLDMAWDGTAIFGGERSKRYALVVEQGRVKTVAVEPDNTGLSVSLAEKVLGPAPQHKLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2W1</accession>
    <name>G0S2W1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0018680</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692363.1">
        <property type="nucleotide sequence ID" value="XM_006692300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2W1"/>
    <dbReference type="STRING" id="759272.G0S2W1"/>
    <dbReference type="GeneID" id="18255906"/>
    <dbReference type="KEGG" id="cthr:CTHT_0018680"/>
    <dbReference type="HOGENOM" id="CLU_1758594_0_0_1"/>
    <dbReference type="OrthoDB" id="2308815at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS22344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="148" mass="15973" checksum="8363CF6369D825A4" modified="2011-10-19" version="1">MQDEELLRKPSQGKLTSLLTDWVHGWQATALLLHAIGICPMATPSVWYSPHGSLNTEPMLRARGIDPHNPSITNTAAAAARIAAHTALFTAAKLHHGMPFAGAAARSAIPQPIGSPRTQVLKLLLCRSSMSGRNPRIRSPYFLSPTHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0S357</accession>
    <name>G0S357_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0019750</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692459.1">
        <property type="nucleotide sequence ID" value="XM_006692396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S357"/>
    <dbReference type="GeneID" id="18256013"/>
    <dbReference type="KEGG" id="cthr:CTHT_0019750"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_806536_0_0_1"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="181"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="344" mass="38899" checksum="43672ED2AF58308A" modified="2011-10-19" version="1">MLDPTGIVGVIGVAGQILEYAFKFYNNWKDAKAEAKSFILEVAALKTILLHVHNLLSDPKFANAFEEDSSALLSELDPEHDADTAILLSACEDELQRLLAKIKKRADAHRFGWECLKAALDGGKAREAVENLHRRFQTLTLLFERDQLALQTKTLQQTIEAREDQNRNHQTQVQKLWSIEQRMNDQTVEQLIANLIKQLLSDKFPPPPAVMDAYAQHKKHRSQPSLSDLEAMFHAVAALHKDGVFVIVDALDECQMSDSVRSNFIEALLRLQSRESNVNILATSRPVPDIVEAFDGHSRLEIVARRDDIERYMRNRMSTLRTVSKNPELQHEIISCIASVANGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>G0S383</accession>
    <name>G0S383_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Eukaryotic translation initiation factor 3 subunit E</fullName>
            <shortName evidence="4">eIF3e</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">INT6</name>
        <name evidence="7" type="ORF">CTHT_0020050</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the eIF-3 subunit E family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692485.1">
        <property type="nucleotide sequence ID" value="XM_006692422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S383"/>
    <dbReference type="STRING" id="759272.G0S383"/>
    <dbReference type="GeneID" id="18256043"/>
    <dbReference type="KEGG" id="cthr:CTHT_0020050"/>
    <dbReference type="eggNOG" id="KOG2758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031132_0_0_1"/>
    <dbReference type="OMA" id="NCPWILR"/>
    <dbReference type="OrthoDB" id="417252at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21378">
        <property type="entry name" value="eIF3E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03004">
        <property type="entry name" value="eIF3e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016650">
        <property type="entry name" value="eIF3e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019010">
        <property type="entry name" value="eIF3e_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10317">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09440">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21357">
        <property type="entry name" value="EIF3E_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016255">
        <property type="entry name" value="eIF3e_su6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01186">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="240"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS22466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="446" mass="50924" checksum="10E1BFC9C4E2E084" modified="2011-10-19" version="1">MAVDASNGRPSVAEYDLILKLAPHLDRHLLFPLLEFAAGQLVDEETNEVKDPAKAREITQAKYALLKKTNMTDYVANLYCELEGVKDAPAEFAERKQKVVGQLEKLEKETSKIRELLERDDVVDKLRSDKVANLEYLKGTHQVTIEMVNALFDFGNLHYSCGNYGDASELLYRFRVLSTDNDKVSYATWGRLACEILTMNWESAMEELQKVKELIDSKLSQNAVAQLQHRTALVHWALFPLFNYDKAREPILDLFMSPAYINSIQAYTPWILRYLTVAIVTARGRVKNSGVQQKHLKDIVRIIKQEAYEYQDPVTQFIHALFIDFDFEDAKQQLVLAEEVCRSDFFLLAHASEFVENARILMFESYCKIHARISLRELSGLLGLTADAAEKHIVNYIRDTRLDAKIDYKEGTVVMNHPPSSVYQQVIEKTKGGFFRTQVLSAAVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3Z2</accession>
    <name>G0S3Z2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0021950</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692664.1">
        <property type="nucleotide sequence ID" value="XM_006692601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3Z2"/>
    <dbReference type="STRING" id="759272.G0S3Z2"/>
    <dbReference type="GeneID" id="18256233"/>
    <dbReference type="KEGG" id="cthr:CTHT_0021950"/>
    <dbReference type="eggNOG" id="ENOG502SA7D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_993976_0_0_1"/>
    <dbReference type="OMA" id="QMSHERD"/>
    <dbReference type="OrthoDB" id="10263401at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13376">
        <property type="entry name" value="OmdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="280" mass="31682" checksum="A5B1DE2969602CAE" modified="2011-10-19" version="1">MPERIRQTARSKRDGKPAATPWGSATIPTKHFEDAAAWEAWLEQNYGDPDGIWMKISRRGSGIPSVTYDQALDIALCFGWIDGQRKSLDAQFFLQRFAPRRKNSNWSKRNVEKVTALIEAGRMRPPGQAEIDAAKADGRWEKAYASPSVIEVPDDFQRALNKNPKAKAFFESLSKMKRYPFLYRLEIVKREETQLDSLLSRLVDFCILLSLLERAEVLKNFAELELCLTRLECTTCPAGKAEAMGEDQFARPAQLGTGRINAALRTVSCSNQQHCAQHPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G0S456</accession>
    <name>G0S456_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy-related protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0030770</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693526.1">
        <property type="nucleotide sequence ID" value="XM_006693463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S456"/>
    <dbReference type="STRING" id="759272.G0S456"/>
    <dbReference type="GeneID" id="18257115"/>
    <dbReference type="KEGG" id="cthr:CTHT_0030770"/>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_172_2_1"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13993">
        <property type="entry name" value="STKc_Pat1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000549">
        <property type="entry name" value="Protein serine/threonine kinase (Ran1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF68">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATG1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="58"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="333"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="383"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS21230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="546" mass="61228" checksum="0A1533BA1C7199F5" modified="2011-10-19" version="1">MQHVSVFGYPTPPASPAFDQPCAIPAQHLTIHHQHPCLPRYPPITPEERLGRFITGSLQLTEIVGTGAYGVVYSAVDTKTQVRYAVKCLSRFNPDGTPLDQRQLAFQTREIRLHYLASKHKNVVSILKIIDAPDAIYVVLEYCPEGDLFFNITERGQYVGKDDLAKQVFLQILDAVEHCHKLHIYHRDLKPENILVSDQGRTVKLADFGLATSSEKSEDYGCGSTFYMSPECLDHSSSKPFYYCAPNDVWSLGVILVNLTCGRNPWKQASMEDSTYRAYTRNRDFLKTILPVSDELNDILGRIFTRNPEQRITLPELRRRILACSKFTEQQPAATLSQEPILPGPAVSPYVCDDDSPMGDGDACEYDDDDSAAAEYDHDVPLSPTSSEGGSTCSSGSSSSSSSFTSTCSSIDEFDKDEEEFAEDRAEVKTPPPPTTLPTEPAVCEAEDLRMAFPPQVHYQQQHYQHPQAMSQYPHAYDMPVQEPVYHPHPIPVPPQAACTPKFYQLQHYVYEMFRPAQPTTPATSQLRHPVPFYPQISLFAHMPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4D1</accession>
    <name>G0S4D1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Enoyl-CoA hydratase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0039750</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS22089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694385.1">
        <property type="nucleotide sequence ID" value="XM_006694322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4D1"/>
    <dbReference type="STRING" id="759272.G0S4D1"/>
    <dbReference type="GeneID" id="18258013"/>
    <dbReference type="KEGG" id="cthr:CTHT_0039750"/>
    <dbReference type="eggNOG" id="KOG1680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_6_1"/>
    <dbReference type="OMA" id="VGRAFCT"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000074">
        <property type="entry name" value="Enoyl-CoA hydratase (AFU_orthologue AFUA_2G10650)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF152">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G03410)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS22089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="29567" checksum="40BFE104157481A7" modified="2011-10-19" version="1">MASRQPREYKHFRVSYPDKHIVQVTINRPDKLNCINKETSAEIAQVWDELDGDESLWVGIITGVGRAFCTGADLHEWNEMNRAGVVNSMAAPGLAGLPRRSGKKPIIAAVNGICMGGGFEMVANCDVVIAAASAIFSLPEVKRGIVPVAGCLPRLTRTLGLQRTMDLVLTGRTVEAKTLHDWGLVSRLVPAGQDVAQAAVEVAREMCRNSPDALIVGRLGVRMSWEYGNVEESVSALEHSWYPKLMAGANFAEGIRAFTEKRAPKWLDSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4M3</accession>
    <name>G0S4M3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate aminotransferase</fullName>
            <ecNumber evidence="7">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0031520</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="7"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693594.1">
        <property type="nucleotide sequence ID" value="XM_006693531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4M3"/>
    <dbReference type="STRING" id="759272.G0S4M3"/>
    <dbReference type="GeneID" id="18257190"/>
    <dbReference type="KEGG" id="cthr:CTHT_0031520"/>
    <dbReference type="eggNOG" id="KOG1412">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032440_1_2_1"/>
    <dbReference type="OMA" id="GTWTHIT"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000064">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF55">
        <property type="entry name" value="GLUTAMATE OXALOACETATE TRANSAMINASE 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="9">
        <location>
            <begin position="68"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS21298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="450" mass="49216" checksum="2BAB24E2AB74FD4E" modified="2011-10-19" version="1">MASISPRRSSSPSSPSQQHSTALSRLQTIAKHMASVSITNFPAEVVPQAPEDPLFGLSRAYKADPSPDKIDLGIGAYRDDNAKPWVLPVVKKADEILRNDPDANHEYLPIAGLASLTSKAAELLLGTNAPAIAEKRVASVQTISGTGAVHLGALFLSKFYKAEGANRSVYLSNPTWANHHQIFSNVGLPLATYPYFDKETKGLDLDGMKAALENAPDGSIVLLHACAHNPTGVDPTLDQWREIAALMKAKKHFPFFDCAYQGFASGDLDRDAAAIRLFVEEGFELVIAQSFAKNFGLYGQRAGCFHFVAAPSEEAEDITTRVASQLAILQRSEISNPPIYGARIASIILNDPALFAEWQENLRTMSGRIIEMRKALRSKLEELGTPGQWNHITDQIGMFSFTGLTEAQVAKLRTDFHVYMTKNGRISMAGLNSRNIDYFARAVDQVVREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4V1</accession>
    <name>G0S4V1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0031770</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693618.1">
        <property type="nucleotide sequence ID" value="XM_006693555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4V1"/>
    <dbReference type="GeneID" id="18257215"/>
    <dbReference type="KEGG" id="cthr:CTHT_0031770"/>
    <dbReference type="eggNOG" id="ENOG502S5KH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013815_0_0_1"/>
    <dbReference type="OMA" id="QACKLAC"/>
    <dbReference type="OrthoDB" id="5421041at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.730">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="691"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="53"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="254"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="696"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS21322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="743" mass="83613" checksum="2FD74BCD4E83A37A" modified="2011-10-19" version="1">MGSHLDADPTQAVDGLVRAIRDLTSDPNYKLVADVFSEFLYVKEQNNKLSSSHQVVLEEYRKFRNELEAQKEELLKEKQELEGLVQEKVQEILQMQAARARLESDLEDTQKLIERERSAAAQAVENIKKEYAELQAAKTLVEQEKKLGEELAAAAAAKAAEEIAALTQANNKLMEIQASHDSVVKSLKGHIADLQSAKKTLEQIKADNELEIARLAESKLNLEKIKARNDVEIEGLKAKVSDLYTSKTSLEQIKMDNEAKIATLKERVESLEQVKKNLERELEAAQKEIASLKDTIAHKNNEIESLQESLRAAEEQITSLQQTVDEKNAEIEDLHAKLKAEGERANKAEEHGRDLQIQLEETTQNLQTTSEKLRELEQYRILLQDEPDDTYVTILDKIWTTIVTLVESTFRPDIDEAILADPSCWTNLRNSPYLKHATQLQIPLPQSNSPAAKGMRISAVLSVLSRAMHKHLFRPVYLLDDDDENLVRFLRALEDEDPEREAHIRATLLAAMPERQLEQGARRVKTVVREVSWLVQHLLSALQFEAFCAGLEAACKLACEQWMRIQVANMKIEPYFGPPYDDFDWQVLELPEFAEAADRDPGMPHTRADTDEAAIDDRLDEADRAASAATGSQLFNDSAIEAQEEMLDGEIDPDEILLVVWPSMCAVENGELMSITQGLVISKEQARPALEEQRARSRMISRPGSRRARTMSMPGHSRASSPRGRPYAGGTHPSSEAVTVDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G0S522</accession>
    <name>G0S522_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="4 14">1.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CTHT_0023800</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 14">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="4 14"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692843.1">
        <property type="nucleotide sequence ID" value="XM_006692780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S522"/>
    <dbReference type="STRING" id="759272.G0S522"/>
    <dbReference type="GeneID" id="18256418"/>
    <dbReference type="KEGG" id="cthr:CTHT_0023800"/>
    <dbReference type="eggNOG" id="KOG0786">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_275947_0_0_1"/>
    <dbReference type="OMA" id="RIMASEF"/>
    <dbReference type="OrthoDB" id="419183at2759"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004429">
        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00169">
        <property type="entry name" value="leuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979:SF1">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5 14" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0520">NAD</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="16">
        <location>
            <begin position="792"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="65"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="354"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="563"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="113"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="372"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="509"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="591"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="638"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="677"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGS20547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1155" mass="122914" checksum="939C448D12743E5D" modified="2011-10-19" version="1">MSADQPASSFADSTPRPPTPKRTPKLAILPSPVFETPKNNQGRSDESTGWTPRFAEEFSVFNSTPGNFKSLLQSPFPDFSLGTPFSAPSRQKDHLLTEPIVESAVHANELSPEPNQTQPPVESSKALQSPPTSECTPAFSDSASVELPSGPGERSAKKSRRNTAGQETQRQVATPPPTARKGERKIAPKLDTSAMQNDQDFDPQSHFMATAPQGVGNFMTTQGNMFGYPLSAPAAAPGFDPQRSFWDADSSLAGMEIDFGANGAGMFQSSASQQDGGSVDWIRTNPLLHAQGGLMSHANGQVSHGDCQAALVSQPPVSMLVTSADAHAMFATTSYPTPIDDPFGISGNPGGAVNPGLLLSRPPSASMDPAPSFNQQPVRAPSSSLLPAADDDRQISPSRGSSSSATSASTCGQKASGKGELRRSASAKDSPRKPDRTMSSSPVKGVVRLDLSRSLSENRGKKTTATARPSLPPLAPAPRPQSQLMSSAGMGVNRPIMPHPPQRPHMARSLPPKTSSSNSSSSGHHHHRLPSLTSIPEASPGPQMRTQAKFTIDENGRAHVETIVVVNEPPPSTHKRHSIYALPRRPRPEWDSSDDESSSSTDDEPIIIPSRNASFALPDPRKPSAIRSFQSSQKSMSERSVSSASFSSCASFSNSSSRPGSQRRGGTANDSDEETVVNDTTPTRSNGNALSELQKLRESRQRQQQLPDIGVMSSCNQTIGPWMQSAEPGAPEPQGADADARADPKCLAVPGGRRLRKAGFKEHLGSRWHWMRLRTQHTQDINDSTANMATHNIVVFAGDHCGPEVVAEAIKVLKAIEEHSPSAGKFNLQEHPLGGASINKHGVPLTDEALAAAKAADAVLLGAIGGPEWGPSSPVRPEQGLLKLRKELGTFGNLRPCSFASDLLVNSSPLKPEVCRGTDFVVVRELTGGIYFGDRKEDDGSGFALDTEPYSREEIERIARLAGFLALARNPPAKVWSLDKANVLATSRLWRKVVTEVFEKEFPQLELQHQLIDSAAMIMVKNPRALNGIVITSNLFGDIISDEASVIPGSIGLLPSASLGGIPDGNGKCNGIYEPIHGSAPDISGKGIVNPIGTILSVAMMLRYSLNLPKEANAVEEAVKRAIDGGVRTRDLGGTAGTKEMGDAVVAELVKLLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0S622</accession>
    <name>G0S622_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0033900</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM U1 A/B'' family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693826.1">
        <property type="nucleotide sequence ID" value="XM_006693763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S622"/>
    <dbReference type="STRING" id="759272.G0S622"/>
    <dbReference type="GeneID" id="18257428"/>
    <dbReference type="KEGG" id="cthr:CTHT_0033900"/>
    <dbReference type="eggNOG" id="KOG4206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041869_0_1_1"/>
    <dbReference type="OMA" id="VRMIPTK"/>
    <dbReference type="OrthoDB" id="266020at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030532">
        <property type="term" value="C:small nuclear ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12246">
        <property type="entry name" value="RRM1_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12247">
        <property type="entry name" value="RRM2_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000039">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000029">
        <property type="entry name" value="U2 small nuclear ribonucleoprotein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="12"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="175"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="111"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS21530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="250" mass="27814" checksum="811EB369120F98AD" modified="2011-10-19" version="1">MASNQGQQPPIATVYVRNLEERVKVDKLKEALYTIFSEYGNVIDIVAKTNLKAKGQAFIVFDKPEPALTAVEELQGFELFEKPMQVALARTRSDATVQRYCSEEEFEAHKRHRMAEKERKKAAEAEEQKRLKRPIPGSGVEAGARPAKSARGPGLKSTAPGAAPVVPDEYLPPNRILFVQNLPDDFDKDALTAIFGRFEGFREVRMVPGRSGIAFVEYESEAGAITAKENTAGMPLKNGEKIMKVTYQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0S698</accession>
    <name>G0S698_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0025980</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693058.1">
        <property type="nucleotide sequence ID" value="XM_006692995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S698"/>
    <dbReference type="STRING" id="759272.G0S698"/>
    <dbReference type="GeneID" id="18256636"/>
    <dbReference type="KEGG" id="cthr:CTHT_0025980"/>
    <dbReference type="eggNOG" id="ENOG502SPR4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_783036_0_0_1"/>
    <dbReference type="OrthoDB" id="5280547at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DBAG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS20762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="39093" checksum="A2002398493673D9" modified="2011-10-19" version="1">MCFTILAQVQRSLQHSSPQPTLAIPFTPKGILSDGKAFPKSIFEWIDLASRFVSSEDKPAAQLLPIVLRLVKLSARVHSQPLMDGDPQTANVIHEVLQLDDALAAWEDQVRTHNTNTNTNGNDSTTNTNIWTVTEDLLSNYAPSPTADPVPPQAVFDGAYHVYSDMFVARTWNHYRWARILTCQMLLEAAFRFPMTNTTSFPNALISPARIQSSLTVISRLARDILVSTPSHYRHPSLRPKHWACSIFDRTHGGAVIGFAGVPTLLFEIKVAGCAPGVEAKCREWALGLLETAWKDTGMGQARLLMEIVEGIVEGERRRSDMKNRMEGIIPNGQGNGNGMGTQRGMGFAMLAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6E7</accession>
    <name>G0S6E7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0034650</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693898.1">
        <property type="nucleotide sequence ID" value="XM_006693835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6E7"/>
    <dbReference type="STRING" id="759272.G0S6E7"/>
    <dbReference type="GeneID" id="18257503"/>
    <dbReference type="KEGG" id="cthr:CTHT_0034650"/>
    <dbReference type="eggNOG" id="ENOG502S0ZE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024263_0_1_1"/>
    <dbReference type="OMA" id="FKAGANW"/>
    <dbReference type="OrthoDB" id="3357002at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021460">
        <property type="entry name" value="DUF3112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35184:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35184">
        <property type="entry name" value="YALI0C10208P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11309">
        <property type="entry name" value="DUF3112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS21602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="382" mass="42029" checksum="96F316D237256DE3" modified="2011-10-19" version="1">MASSQQPQLPVLPGPPYPPTTAQLGLVPSIIPDVPISSALLALFLGGAATNLVIFRANRKRGFRFVFSMVFFVFCVIRIAALALRIAWACHKRNVRLGIAAQIFTAAGVLVLFVSNLAFALRFVRAYHPSLGWKQWVKCVFGVLFASAVTVLAMVITVTVQGFFVKEGSSVKEIDRKIQLVCGTYLAAYAFLPVPIAVGAALWPKRTRIDPFGQGQLGTNLGLLTTGALLLTAGATFRAVVTFLQRPIRDPGWFHSRACFYIFNFTIELLVVYLYTLARFDKRFHVRDGSSAPGHYSCVDLKQGDMTALAEAMSAANERIEDNEGDRKSDSRWRIGSRPKSANDSYVARPVEMSNQERDADLAWLACALNILYGEELDKQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6P1</accession>
    <name>G0S6P1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0035080</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693939.1">
        <property type="nucleotide sequence ID" value="XM_006693876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6P1"/>
    <dbReference type="GeneID" id="18257546"/>
    <dbReference type="KEGG" id="cthr:CTHT_0035080"/>
    <dbReference type="eggNOG" id="ENOG502RG32">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100306_0_0_1"/>
    <dbReference type="OMA" id="NNAQGGH"/>
    <dbReference type="OrthoDB" id="3050608at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40462">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40462:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="135" mass="14645" checksum="79CEDE049ECF86BB" modified="2011-10-19" version="1">MDLLGKLANQAVTNLAQTQQQQQQQQPQQQQSQSKTDNLLNKLHGLAGGGPESEKKEDALDKGIDWVQEHILKQGPQNNESAAEQAKDKIIADMIRDGFQKATGKPFPIKEKEEEKPSATSVVSGLAGAFLGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0S755</accession>
    <name>G0S755_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exosome complex component RRP45</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Ribosomal RNA-processing protein 45</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0027490</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2024" name="bioRxiv" volume="0" first="0" last="0">
            <title>Beyond static structures: quantitative dynamics in the eukaryotic RNA exosome complex.</title>
            <authorList>
                <person name="Liebau J."/>
                <person name="Lazzaretti D."/>
                <person name="Bichler A."/>
                <person name="Pilsl M."/>
                <person name="Sprangers R."/>
            </authorList>
            <dbReference type="DOI" id="10.1101/2024.01.28.577622"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.19 ANGSTROMS)</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693206.1">
        <property type="nucleotide sequence ID" value="XM_006693143.1"/>
    </dbReference>
    <dbReference type="PDB" id="8PEL">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.81 A"/>
        <property type="chains" value="A=1-293"/>
    </dbReference>
    <dbReference type="PDB" id="8R1O">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.19 A"/>
        <property type="chains" value="A=1-293"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S755"/>
    <dbReference type="EMDB" id="EMD-18825"/>
    <dbReference type="SMR" id="G0S755"/>
    <dbReference type="STRING" id="759272.G0S755"/>
    <dbReference type="GeneID" id="18256787"/>
    <dbReference type="KEGG" id="cthr:CTHT_0027490"/>
    <dbReference type="eggNOG" id="KOG1614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038194_0_0_1"/>
    <dbReference type="OMA" id="GPQFENG"/>
    <dbReference type="OrthoDB" id="10264038at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11368">
        <property type="entry name" value="RNase_PH_RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000005">
        <property type="entry name" value="Exosome complex component RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033100">
        <property type="entry name" value="Rrp45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF14">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="15 16" id="KW-0002">3D-structure</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="11">
        <location>
            <begin position="32"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="12">
        <location>
            <begin position="190"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS20910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="8PEL"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="8R1O"/>
        </source>
    </evidence>
    <sequence length="293" mass="32432" checksum="E4AD2C65437281B5" modified="2011-10-19" version="1">MPREVEPSLSERQFVLQALQEGLRLDGRQLDQYRPLSLTFGDQYGVADVTFGKTRVLAKASAEVTVPYADRPLDGIFTIATELSPMTSPTFEVNRPTETEVLLSRLLEKTIRRSGALDTESLCLVAGQKCWSIRVDVHVMSHDGNLVDAACIAVVAALRHFRKPDTSIESGVLTIYTPAEREPVPLSWLHTPFCVTWSFFGDEGEIAVLDATWLEEQVRVGSCTISMNKHGEICQIAKLGGTPVEAVSLLQCTSIALTKVKEFSDLVDKKLAEDFKRRNPGGLLKELKAENDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0S785</accession>
    <name>G0S785_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0027790</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693236.1">
        <property type="nucleotide sequence ID" value="XM_006693173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S785"/>
    <dbReference type="GeneID" id="18256817"/>
    <dbReference type="KEGG" id="cthr:CTHT_0027790"/>
    <dbReference type="HOGENOM" id="CLU_1610562_0_0_1"/>
    <dbReference type="OMA" id="TQMNDSA"/>
    <dbReference type="OrthoDB" id="4590707at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="165" mass="17499" checksum="710AEC2FC01B7F3F" modified="2011-10-19" version="1">MFRLAAKRVTLQFRRALGRRSYATEHQPDLQERIGMASDRPWQMAALAITIPGVYYLRRGATRHLDAKHPGEIQIGSKKLKDTKPGKKAAEAISDLMTATEPLRDQASQAMQSMTPGSSGSSSAGANTPSSGSVSSAMSSAAGTVSATTEKMGEAAKEMVGMGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7I2</accession>
    <name>G0S7I2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative cleft lip and palate protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0028230</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLPTM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693280.1">
        <property type="nucleotide sequence ID" value="XM_006693217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7I2"/>
    <dbReference type="STRING" id="759272.G0S7I2"/>
    <dbReference type="GeneID" id="18256861"/>
    <dbReference type="KEGG" id="cthr:CTHT_0028230"/>
    <dbReference type="eggNOG" id="KOG2489">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019907_2_0_1"/>
    <dbReference type="OMA" id="TLWAHFY"/>
    <dbReference type="OrthoDB" id="378564at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008429">
        <property type="entry name" value="CLPTM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347">
        <property type="entry name" value="CLEFT LIP AND PALATE ASSOCIATED TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347:SF0">
        <property type="entry name" value="LIPID SCRAMBLASE CLPTM1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05602">
        <property type="entry name" value="CLPTM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="514"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="613"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="619"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS20984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="659" mass="74777" checksum="1ACB5175E1C671A4" modified="2011-10-19" version="1">MPQANAVAGRQPARPQQRDEGPSLFSRVFQAVAMYMAMQFLMKQFMGPPKTAQVRDANGNVVQVSTHVPPYHERPTRLNDGATYSKIPQLLGPIWGDDSTVDIVVTVSSSFVPTPLRQTSKESIVLEEKKFKIGNWSDTRIVEGTITVPEPVQHNGTLWGHFYVGLPGAILDPTEQGYDPGSAYHFVYPLTQYLPKKKEVKTRNLLADKGEAGEAEPVEDEPEPTGPIIANYYHPNVSLSFIPNTGVISYTQAHPIVRHFLHLEATGARDGTGQHSWYYPILFVNTFWQLRSHMTLLNETVQTLPIRITLNNLSEWKFKTMASIEFSSKEAARQAAYGNSLPGGGDGSEIEMIKEIFMDSNPILLGVTIVVSIAHMVLETLAFGSDIQHYRKKKDNVGISLRSILGNVFMQTVIFLYLIDQSENTSWMILGGQAVGIIIELWKITTVVNVRLRPAPGSLIPYRIKFEDKHKLSETEQKTKEYDEEAFRYMYIAAVPLLIAYAIYSLLYETHKSWYSYIITTLVGSVYAYGFLMMVPSLYINYKLKSVAHMPAKAMMYKFLNTFIDDLFAFTIKMPILHRLATFRDDVIFFIYLYQRWIYRVDYTRVNEFGQGGEDENEELIRKAKEEEEKKKKNALPEKPEQETAKSTGADAPKATKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7M3</accession>
    <name>G0S7M3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0036840</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the proteasome inhibitor PI31 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694110.1">
        <property type="nucleotide sequence ID" value="XM_006694047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7M3"/>
    <dbReference type="STRING" id="759272.G0S7M3"/>
    <dbReference type="GeneID" id="18257722"/>
    <dbReference type="KEGG" id="cthr:CTHT_0036840"/>
    <dbReference type="eggNOG" id="ENOG502RZMJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044125_2_0_1"/>
    <dbReference type="OMA" id="GHACMVA"/>
    <dbReference type="OrthoDB" id="68090at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1000.30:FF:000006">
        <property type="entry name" value="Chromosome 8, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045128">
        <property type="entry name" value="PI31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013886">
        <property type="entry name" value="PI31_Prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021625">
        <property type="entry name" value="PI31_Prot_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13266">
        <property type="entry name" value="PROTEASOME INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13266:SF1">
        <property type="entry name" value="PROTEASOME INHIBITOR PI31 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08577">
        <property type="entry name" value="PI31_Prot_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11566">
        <property type="entry name" value="PI31_Prot_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PI31 proteasome regulator N-terminal" evidence="13">
        <location>
            <begin position="27"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="PI31 proteasome regulator C-terminal" evidence="12">
        <location>
            <begin position="280"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="187"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="204"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS21814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="398" mass="41810" checksum="A0A2878D608685C8" modified="2011-10-19" version="1">MAPDPLAPAAVLESMANALPTHEKDDTTSDLSSSLDCISLFVHACLFNLGFRLLGFSEDQKIECQRLAPRLPAQWNKSLSSHSFVYAHTQSSMQFVIHIDRMGSKIDIRGLAIGDERIAHFDITARDYISSSALPVRITMTSEGTEDRSDLPSKLKNVFISDERIKDLSTLLKVSLIQRLLPGLHKEGYTEEPLPSGSSSSRPPIQPPQHPRPQIPAHLPPPAAPNPYPAPDPLAAPPSRPIPAADFPPPDFEDEYEVNRPPRSPVPGSQPGFGPGFGNLGHDDLYPAGLGPNDPIRGSFTGEFGIGPAGLARPGAGTRGGGGMHPTFDDPLFGGPRGPGATGGVEDPFGGQVPPGARWDPLGPGGQPRVGGGRPGGRGGGAYGGSGYGFGGFGGDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7V7</accession>
    <name>G0S7V7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-directed RNA polymerase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0037150</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694140.1">
        <property type="nucleotide sequence ID" value="XM_006694077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7V7"/>
    <dbReference type="STRING" id="759272.G0S7V7"/>
    <dbReference type="GeneID" id="18257753"/>
    <dbReference type="KEGG" id="cthr:CTHT_0037150"/>
    <dbReference type="eggNOG" id="KOG2354">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045565_0_0_1"/>
    <dbReference type="OMA" id="QHPNRTD"/>
    <dbReference type="OrthoDB" id="340681at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006886">
        <property type="entry name" value="RNA_pol_III_Rpc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES III 80 KDA POLYPEPTIDE RNA POLYMERASE III SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04801">
        <property type="entry name" value="RPC5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="363" mass="39105" checksum="7E5A9CE824AD4AEB" modified="2011-10-19" version="1">MSSNAPRGAPAGPQYDDDPVVATYSVFIKPPLPQNRNLVVLQYVDKIAQDPSQIRMPRITELRVKPETGMYEVDMPIDTTEAYDRNKGIMWGTALAKSMEAKKGGSLGLAGGFNIVATSNPAGRSRGRGGNDDEGPLTWAEAVRQDKVLRTQTFGGVRSAQEKHTRHMVGVFQGKNLHLTPVSSVVHLRPVPHHIDALTEQERLSRGASGAGASSSDKAGTASGARAIHMTIKSAMDGDGGVATETIADRLRKVQMEPWRRMEWVHDEAELAWEAYNECLLLRPSTESAAGGEKVVGDEVVDGAVGEEKDPKGKGKEVAGSGTVDGGAADLVDRVPHLKTDWGEKELLQAMSGEKPKKRGTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>G0S867</accession>
    <name>G0S867_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="27">Fatty acid synthase subunit beta</fullName>
            <ecNumber evidence="5">1.3.1.9</ecNumber>
            <ecNumber evidence="7">2.3.1.38</ecNumber>
            <ecNumber evidence="8">2.3.1.39</ecNumber>
            <ecNumber evidence="4">2.3.1.86</ecNumber>
            <ecNumber evidence="3">3.1.2.14</ecNumber>
            <ecNumber evidence="6">4.2.1.59</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="32" type="ORF">CTHT_0037750</name>
    </gene>
    <organism evidence="33">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="32 33" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="33">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="34" key="2">
        <citation type="journal article" date="2022" name="Structure" volume="30" first="575" last="589.e6">
            <title>Cryo-EM and artificial intelligence visualize endogenous protein community members.</title>
            <authorList>
                <person name="Skalidis I."/>
                <person name="Kyrilis F.L."/>
                <person name="Tuting C."/>
                <person name="Hamdi F."/>
                <person name="Chojnowski G."/>
                <person name="Kastritis P.L."/>
            </authorList>
            <dbReference type="PubMed" id="35093201"/>
            <dbReference type="DOI" id="10.1016/j.str.2022.01.001"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (4.47 ANGSTROMS)</scope>
    </reference>
    <comment type="function">
        <text evidence="26">Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The beta subunit contains domains for: [acyl-carrier-protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>(9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15057"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9924"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78783"/>
            <dbReference type="EC" id="3.1.2.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:13097"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="4.2.1.59"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10240"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>holo-[ACP] + acetyl-CoA = acetyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41788"/>
            <dbReference type="Rhea" id="RHEA-COMP:9621"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78446"/>
            <dbReference type="EC" id="2.3.1.38"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>holo-[ACP] + malonyl-CoA = malonyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="20">[Alpha(6)beta(6)] hexamers of two multifunctional subunits (alpha and beta).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 28">Belongs to the fungal fatty acid synthetase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.9" evidence="5"/>
    <dbReference type="EC" id="2.3.1.38" evidence="7"/>
    <dbReference type="EC" id="2.3.1.39" evidence="8"/>
    <dbReference type="EC" id="2.3.1.86" evidence="4"/>
    <dbReference type="EC" id="3.1.2.14" evidence="3"/>
    <dbReference type="EC" id="4.2.1.59" evidence="6"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694197.1">
        <property type="nucleotide sequence ID" value="XM_006694134.1"/>
    </dbReference>
    <dbReference type="PDB" id="7Q5S">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.47 A"/>
        <property type="chains" value="B/C/E/G/I/K=1-2122"/>
    </dbReference>
    <dbReference type="EMDB" id="EMD-13846"/>
    <dbReference type="SMR" id="G0S867"/>
    <dbReference type="STRING" id="759272.G0S867"/>
    <dbReference type="GeneID" id="18257813"/>
    <dbReference type="KEGG" id="cthr:CTHT_0037750"/>
    <dbReference type="eggNOG" id="ENOG502QQJX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000114_5_0_1"/>
    <dbReference type="OMA" id="HFMDNYG"/>
    <dbReference type="OrthoDB" id="5417908at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004313">
        <property type="term" value="F:[acyl-carrier-protein] S-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016297">
        <property type="term" value="F:fatty acyl-[ACP] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03447">
        <property type="entry name" value="FAS_MaoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.120:FF:000001">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.70:FF:000001">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000017">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000078">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.100:FF:000001">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000015">
        <property type="entry name" value="Fatty acid synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2430:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000003">
        <property type="entry name" value="Fatty acid synthase subunit beta dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="FAS1-like_DH_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016452">
        <property type="entry name" value="Fas1/AflB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013565">
        <property type="entry name" value="Fas1/AflB-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041099">
        <property type="entry name" value="FAS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040883">
        <property type="entry name" value="FAS_meander"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003965">
        <property type="entry name" value="Fatty_acid_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08354">
        <property type="entry name" value="Fas1-AflB-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="FAS1_DH_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22235">
        <property type="entry name" value="FAS1_thioest_ins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17951">
        <property type="entry name" value="FAS_meander"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17828">
        <property type="entry name" value="FAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005562">
        <property type="entry name" value="FAS_yeast_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01483">
        <property type="entry name" value="FASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="34" id="KW-0002">3D-structure</keyword>
    <keyword evidence="17" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="11 28" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="18" id="KW-0456">Lyase</keyword>
    <keyword evidence="19" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15 28" id="KW-0520">NAD</keyword>
    <keyword evidence="13 28" id="KW-0521">NADP</keyword>
    <keyword evidence="14 28" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="33" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 28 32" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="31">
        <location>
            <begin position="1696"/>
            <end position="2017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="30">
        <location>
            <begin position="2098"/>
            <end position="2122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="30">
        <location>
            <begin position="2099"/>
            <end position="2122"/>
        </location>
    </feature>
    <feature type="active site" description="For acetyltransferase activity" evidence="29">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="active site" description="For malonyltransferase activity" evidence="29">
        <location>
            <position position="1840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00033756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00058855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00068309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="PIRNR" id="PIRNR005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="PIRSR" id="PIRSR005562-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="EMBL" id="EGS21901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="34">
        <source>
            <dbReference type="PDB" id="7Q5S"/>
        </source>
    </evidence>
    <sequence length="2122" mass="235175" checksum="627EE66664AC893D" modified="2011-10-19" version="1">MYGTGTGPQTGAVTPRSSASLRPLTLSHGSLETSFLIPTGLHFHASRLKDEFIASLPPPTDELAQDDEPSSVPELVARYMGYIANQVAEGEDDAQGSYEEVLKLILNEFERAFLQGNDVHALVATLPGIDAKKLEVIRSYFAARAATNRAMRAHQSALLRAAEEGEARIYSIFGGQGNIEEYFEELRELYKTYPSFVGHLIVSSAELLQILASHPSAEKLYSKGLDIMHWLHNPDATPDTDYLISAPVSFPLIGLVQLAHYQVTCKVQGLHPGILRDRISGTTGHSQGIVLAAVTAAADSWESFEDLAKSALTILFWIGARSQQTFPRTSMSPSLLQEAIDNGEGTPTPMLSIRDLPQAEVQKHIDQTNQYLPEDQHISISLINSPRNLVVSGPPRSLCGLNAQLRKVKAPTGLDQARIPYSERKIRFVNRFLPITAPFHSKYLAGAAELIAEDLKDISIEVERLGIPVYDTNTGEDIRQTVTGNVVPALIRMITNDPVHWEKATVFPEATHILDFGPGGISGLGVLTSRNKDGTGVRVILAGTVNGTVAEVGYKSELFDRDEEHAVKYAVDWVKEYGPRLIKTSSGRIYVDTKMSRLLGLPPLMVAGMTPTTVPWDFVAATMNAGYQIELAGGGYFNAKMMTEAISKIERAIPPGRGITVNLIYVNPHAMAWQIPLLGRLRAEGVPIEGLTIGAGVPSIEVANEYIQTLGLKHISFKPGSVDAIQAVINIAKANPTFPVILQWTGGRGGGHHSYEDFHAPILAMYSRIRRQENIILVAGSGFGGAEDTYPYLTGAWSTKYGYPPMPFDGCLFGSRMMVAKEAHTSPEAKQAIVDAPGLDDSEWEKTYKGPAGGVITVRSEMGEPIHKLATRGVLFWAEMDQKIFSLPKEKRVAELKKNRDYIIRKLNADFQKVWFGKNKKGEVVDLEDMTYGEVVRRMVELLYVKDEKRWIDHSFAKLTADFIHRVEERFTTAASQPSLIQSYSDLDEPYSAVERVLAHYPEAETQLISAQDVQHFLLLCKRRGQKPVTFVPALDEDFEFYFKKDSLWQSEDLAAVIDRDVGRTCILQGPMAAKHSTKVDEPIKEILDGIHNGHIAALKRDLYDNDESKIPTIEYFGGKLKDPEVQLDFEGVTISYDVHKNTYRVSNNPSVPLPPLDAWLSALAGPNRTWRYALLQSEVIVQGHKYQTNPMKKIFAPARGLFVEIQYPNDPAKTVITVKEQPRPNRYIDVIEAKLVGDKEIVVNLIKDTNALGEPVALPLRFTYRPEAGYAPIHEIMEGRNDRIKEFYWRCWFGQDPLDLDAPVTSKFDGGEAVITSEAINEFVHAVGNTGEAFVDRPGKTMYAPMDFAIVVGWKAITKPIFPRTIDGDLLKLVHLSNQFRMFPGAEPLKKGDKVYTTAQVNAVINQESGKMVEVCGTITRDGKPVMEVISQFLYRGVYTDYENTFQRKVETPMQVHLATTKDIAILRSKQWFVLDDVATPEEFLLGKTLTFRLHTLVHFKNRNVYSHVETRGQVLVELPTKEIIQVATVEYVAGESHGNPVIDYLQRNGQSIEQPVNFENPIPLGGKAPLQLRAPASNETYARVSGDYNPIHVSRVFAAYANLPGTITHGMYSSAAVRSLVETWAAENKIGRVRSFHASLTGMVLPNDDINVKLQHVGMVGGRKIIKVEATNKETEEKVLLGEAEIEQPVTAYVFTGQGSQEQGMGMDLYANSPVAREVWDRADKYLRDTYGFAITDIVRNNPKELTIHFGGPLGKKIRANYMAMTFETVAADGSIKSERIFKDIDENTTSYTFRSPNGLLSATQFTQPALTLMEKASFEDMKAKGLVPRDSTFAGHSLGEYSALAALADVMPIESLVSVVFYRGLTMQVAVERDATGRSNYGMCAVNPSRISKTFNEEALRFVVGAVAETTGWLLEIVNYNIANMQYVCAGDLRALDTLTSVTNFIKAMKIDIEQMRREYSPDKVKEELVEIIKKCAAETEAKPKPLELQRGFATIPLRGIDVPFHSTFLRSGVKPFRNFLLKKINKTSIDPAKLIGKYIPNVTAKPFALTKEYFEDVYRLTNSPRIAHVLANWEKYQDDNSTLSASVANTSSETNGVNGVNGAVDVNGQNGVNGVNGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8I5</accession>
    <name>G0S8I5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinetochore protein Spc24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0030010</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
            <location evidence="10">Centromere</location>
            <location evidence="10">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the SPC24 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693455.1">
        <property type="nucleotide sequence ID" value="XM_006693392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8I5"/>
    <dbReference type="STRING" id="759272.G0S8I5"/>
    <dbReference type="GeneID" id="18257039"/>
    <dbReference type="KEGG" id="cthr:CTHT_0030010"/>
    <dbReference type="eggNOG" id="ENOG502S52R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091441_1_0_1"/>
    <dbReference type="OMA" id="AQCTSHF"/>
    <dbReference type="OrthoDB" id="3344830at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013252">
        <property type="entry name" value="Ndc80_Spc24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22142">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22142:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08286">
        <property type="entry name" value="Spc24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 10" id="KW-0137">Centromere</keyword>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="4 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS21159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="175" mass="19205" checksum="FD88AA3EE4BE9194" modified="2011-10-19" version="1">MLLEEDPSTLISHTLQNFNIAPDKQAISRISESLSTLQQARDLRLREAESSLRRLARTLSTLTAQHNELTSQHNSAHHASEMARLDTQKFRIAKAASDLEMETERLQAQLAELHAKLQELEIQGVEGGVEPGNVPGNGGVEDEVLLRLKVYRSLGMELEREAAGAGGAGDREMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8R3</accession>
    <name>G0S8R3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0040050</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988042">
        <property type="protein sequence ID" value="EGS20266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694415.1">
        <property type="nucleotide sequence ID" value="XM_006694352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8R3"/>
    <dbReference type="STRING" id="759272.G0S8R3"/>
    <dbReference type="GeneID" id="18258043"/>
    <dbReference type="KEGG" id="cthr:CTHT_0040050"/>
    <dbReference type="eggNOG" id="ENOG502QZJZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010813_1_1_1"/>
    <dbReference type="OMA" id="CSHHNIP"/>
    <dbReference type="OrthoDB" id="4116913at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF37">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="224"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS20266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="555" mass="62882" checksum="F83B0D0BAA29790C" modified="2011-10-19" version="1">MECTWNRPISTKRRKRNAVVAPPPPRGRPAPLLGRLHFAGRHLGEISLHNGMPFLSWEGRMWIASRTGDPAPFKAVCEAAESILQRHHLHPSMLCGTAAQPNLDLPDRKAIEEALCMYSATPFKRIWPVIDAVLFQQTIEVAYNPQTACLQEWATAKACIFAFLALLAIHHKYPPSLPILDGEECAVKAQCLLAQVLQETTLVGLQTCFLLALYHLMLGQLQKAAVYNSLACRMLFTLGGHTIVVPLPKSPPSLDWRYDNQLRKMFWMLYSCDKEISLRTGQPPSINDDDCDLTLPHGYVEAKYLEEDMQEADAALLNDTAVPLFPGDLRLDMLKSKTYQLLYSARALRKSDAELIRDIRELDDELEAWRLAVPPTFRPWLSLRHDQPTSMSELRHMERVMVYVEYHRLIAAIHAATGRCSSWSTDKPFEMPEGVGSSMALAVEASRSTLFFIKAIVQNLMGEVFWMAVIYPISAVWTIFCNIIYNPMHAHVDGDLELLNWVPQLIQDMRKRRLARDEMVHMRMIDDFVAELARLAGEAVKKARRDHRSASSASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8R4</accession>
    <name>G0S8R4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0040060</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988042">
        <property type="protein sequence ID" value="EGS20267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694416.1">
        <property type="nucleotide sequence ID" value="XM_006694353.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S8R4"/>
    <dbReference type="GeneID" id="18258044"/>
    <dbReference type="KEGG" id="cthr:CTHT_0040060"/>
    <dbReference type="eggNOG" id="ENOG502QTFK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006822_0_0_1"/>
    <dbReference type="OMA" id="VHEDFFP"/>
    <dbReference type="OrthoDB" id="5418235at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542:SF2">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="562"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="734"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="877"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1230"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="746"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="884"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="898"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1252"/>
            <end position="1273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1285" mass="141799" checksum="36D4AED0172B4A79" modified="2011-10-19" version="1">MESYTRGVPFQRRLSRLYNDTKRKSDFLTQEPAPHADSDPEIQALHRKLRIQKDRLVTWGLEWSDPNQAASASAEVLIDSSLSKAGLSEVVGSIMTTIRDILAEAEQLWNKRHEQVSGGTQRKGEKIRMVVWDRNKFEDLIRDLTTSIDTLYDLSRTRSSFAVSSAAARARLEKPLPSLEEMRPFESTRIKTPQVIDPKTLTPLRLIQAEPMTEPVEHGERVREIVIMKRDAFAELMRKIGSTSAQAHAPLLLEYAYFDDIYTKTGIPPPMNRFEKISAALQAEPQRAPGSWTGLPRMLGYFEDLDSSRFGLVYQFPRTFHAVTFEHLTQHPLNNMCTLADLLARPDFEPRLEAKFRLAANLANTLFDLHDRGVTHCALVTENISFCNAVGTDPEVSGITQGEVDIRRPLLSGFDLFWDPHAPGEEAGEEYSLYRHPLDPRNSAASPLAEKAGSKIFDLYSLAMVLLSVGLWTKLENLVTHPQSPVSEALLDQLAIRCGTLYMKAVQTCWRAVDQELMGAAGSTEEIVRKAQARASRYLEACCILDGVNALEERLGAELGEERMPVESESVPAADVSSSKAAKEKEREAMWERAARGGEAQVQKSKLPSTIRYNQLDANPSVSDPTPVTPKPKLRLYPHVTLPPDVVDHWNKVLMPQINSALRTFYRKHPESVEISLESIGESPQKTRPTVLVVCTSVSKVKAILRKKLGGVFDGESGIGLKVCRGQVVRSRKDVVPTRSMSGSGDGEEDERDNPEEIGAANPDYQEHPTNGASIGAWIGDRHLPPVSLGGLIVVDGKQYGMTVHHMLDDPEQVVRSAAAAAAAAAAATENTPRSMAHEEVQDLAAWYETHCRYQTESEGDNSSVEDAYYACEFSDSESDDISESAITSSYSDPSDGSSEDVPDDEDEDDEESQFSEPGDIPGIEPGCGDGYIITQPALDDMPEGFYPCAETQDEDHLDTCMLGTMYASSGIRRRTDELGFVHEIDWALFKFDERRMMSGNTIPSANFPDEDEEGAEGEGGWISPTSIVPTLLLPGLQVQCMARTSGIQTGVILPTLTSLKIFGRVTPSHTYQIAGVPFSPPSVGKFRSGPGHSIKRSPLPMGVPGDSGAWVISRLPYPDEDNKKEGHALAGHILAFSARKRVAYICPMEVLIRDIGETLCAREIRLPSREDGTAPGEVIWSSKGKRVSVLSTGIRGSGYCYAGELGRRESQRSVSTVGGRTTVTNLSRTASGRSWVTRRASQRSRMSTGYFDEEEEKEKEEEEEEEEYDDKEEGGPGLESKKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0S906</accession>
    <name>G0S906_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative SCP160 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0044100</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694802.1">
        <property type="nucleotide sequence ID" value="XM_006694739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S906"/>
    <dbReference type="STRING" id="759272.G0S906"/>
    <dbReference type="GeneID" id="18258448"/>
    <dbReference type="KEGG" id="cthr:CTHT_0044100"/>
    <dbReference type="eggNOG" id="KOG2208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003293_0_0_1"/>
    <dbReference type="OMA" id="DHAGQQV"/>
    <dbReference type="OrthoDB" id="10027144at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22449">
        <property type="entry name" value="KH-I_ScSCP160_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22450">
        <property type="entry name" value="KH-I_ScSCP160_rpt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22408">
        <property type="entry name" value="KH-I_Vigilin_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02394">
        <property type="entry name" value="KH-I_Vigilin_rpt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054548">
        <property type="entry name" value="SCP160-like_KH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627:SF31">
        <property type="entry name" value="DODECA-SATELLITE-BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22952">
        <property type="entry name" value="KH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="208"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="292"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="381"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="699"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="766"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="859"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="932"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="1013"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="1201"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="808"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS19917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1279" mass="139689" checksum="1CD570BFA707DCD0" modified="2011-10-19" version="1">MASSFAESEPSAASRLLAAHTQNAHHVEVEDVPDEDLPAPVASNANAAEPPKSSAESSAAPKVPAPKTARYEEQFPELGSGTKSAPVAPVWAARAGAANGTPPSSGPSSGINTPNAAAAAAAAAAPRGPRTLTIPGRNVEYMLLDPHHVLPRNQLKRPLVDIVKDFNRRSRAQIKVTTQADGKVRVEATGPQEIATQALKDFIAIIGTKQKINVQIPRIARAHIIGKGGSVIKALQEQTGARIQMPKLPEGEQLPDDEDDDALIDVTIEGNAQQAAAARNAVLKIAGERAGNVNTRVKGIPAVFYPFLASHKETLEKDSGVQIRVPTYHPWSAQPPVVPAPGQRPEFPPAVEELIQLAGEREAVRLAREAIEQRARELHQQLMMEQLSIQRGRHQFIIGERGVPVHKFFEETGCAIILPTDEEDDVVTIVGPADRVHHGVEKAMDLAMNMQCANLDISRFYRQAPGGAAVHARNVTRYLRQRKEIERLEKLYSVHFNTPFSEDGALPWELYSRDGKNALRAQSEIKGLVDAHPPARMATIVVDPFFHHYIRQELSPQVRQNWGVHVVIPDASEASAPVLLVYEGTTNPAEYQLPRVPPTQSEIEAMKKALQEAQNHVLGLINQQESLASRSIEVPEKYHDKLRKFIKKEQDKKPADQMRVRVSNVKSTVNLRGPASAVESLTQKCLEFIEQEKQEEKERGFTLEFDFPQKFANHLIGKGGSHIRELREKFDVEIQVDDGKVILKGPKAKAEAARKHITDFARQLENEVTYVLKIEPKFHGELIGKDGKQIHKLSTRYNVLINFPKTTKGKEEEASGSASDAGKPRRQQAADEVVIRGPKKGADEARDELLSLLQYLKDTSYSATVTVQQKQVPSLIGAGGEALNKLREMTGARIDVPKDAVDGKVEISIKGTKAQVEAAKKILLEKKAIFDDTVVKTIEVDRKHHRALIGAGGSALRDLVVNAGGSAEPAELARTIQFPKQDSDGNTIKIEGRTAVVEKIIAQIQAIVAEREAQITETIDVPVEKHRTLIGRGGEAKRNLEMQFSVSIDVPRQGSGKTGVKIVGRPENVEKAKAHIQELVKEQPGETILVPKALHHAVSNNGQIFRRLRNDFHVTVDHAGHAIPPKPAAPANTRAPTNGSAGLPLITDEAVQPDVHSWVVITRDASADSETIPWVLRGSSAEDVEKAKKAVQSALDQARAHDTTGYLVLPDPRTYRHVIGHGGSKINSIRKKSGCNVTVPREHADGDAIVIVGSKEGVEKAKDMILNAVREGESGRRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G0S929</accession>
    <name>G0S929_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Nicotinamide-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="17">2.7.7.1</ecNumber>
            <ecNumber evidence="17">2.7.7.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CTHT_0044330</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2025" name="Biochem. Biophys. Res. Commun." volume="776" first="152192" last="152192">
            <title>Biochemical and structural characterization of a novel nicotinamide mononucleotide adenylyltransferase from thermophilic fungi Chaetomium thermophilum.</title>
            <authorList>
                <person name="Qian X.L."/>
                <person name="Li J.Y."/>
                <person name="Li C.X."/>
                <person name="Pan J."/>
                <person name="Mu B."/>
                <person name="Xu J.H."/>
            </authorList>
            <dbReference type="PubMed" id="40516445"/>
            <dbReference type="DOI" id="10.1016/j.bbrc.2025.152192"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.11 ANGSTROMS) OF 2-325</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury. May be involved in the maintenance of axonal integrity. Also functions as a stress-response chaperone protein that prevents toxic aggregation of proteins; this function may be independent of its NAD(+) synthesis activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>beta-nicotinamide D-ribonucleotide + ATP + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 17">
            <text>nicotinate beta-D-ribonucleotide + ATP + H(+) = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the eukaryotic NMN adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.1" evidence="17"/>
    <dbReference type="EC" id="2.7.7.18" evidence="17"/>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694825.1">
        <property type="nucleotide sequence ID" value="XM_006694762.1"/>
    </dbReference>
    <dbReference type="PDB" id="9IW1">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.11 A"/>
        <property type="chains" value="A/B=2-325"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S929"/>
    <dbReference type="SMR" id="G0S929"/>
    <dbReference type="STRING" id="759272.G0S929"/>
    <dbReference type="GeneID" id="18258471"/>
    <dbReference type="KEGG" id="cthr:CTHT_0044330"/>
    <dbReference type="eggNOG" id="KOG3199">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033366_0_1_1"/>
    <dbReference type="OMA" id="HFDYELN"/>
    <dbReference type="OrthoDB" id="422187at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09286">
        <property type="entry name" value="NMNAT_Eukarya"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000221">
        <property type="entry name" value="Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051182">
        <property type="entry name" value="Euk_NMN_adenylyltrnsfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045094">
        <property type="entry name" value="NMNAT_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00482">
        <property type="entry name" value="nicotinate (nicotinamide) nucleotide adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039:SF0">
        <property type="entry name" value="NICOTINAMIDE-NUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="22" id="KW-0002">3D-structure</keyword>
    <keyword evidence="11 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 17" id="KW-0520">NAD</keyword>
    <keyword evidence="10 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 17 20" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7 17" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17 20" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="19">
        <location>
            <begin position="61"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="282"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00093425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGS19940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="22">
        <source>
            <dbReference type="PDB" id="9IW1"/>
        </source>
    </evidence>
    <sequence length="325" mass="35981" checksum="6D97820DDD800580" modified="2011-10-19" version="1">MASESSDMATQTRTGLITPVSGIQTPQTPSEPPAMMDSYTFPIHKLKRRQSQPGKTPLVLVACGSFSPITFLHLRMFEMASDFVRFNTDFEVCAGYLSPVSDAYKKAGLAPGHHRVNMCSRAVEPSPWLMVDPYETLNRNERGEPEYVPTAKVLRHFDHEINTVLGGIEGTDGVRRKARIALLAGADLIMSMSEPGLWSPTDLDVILSQYGAFIIERSGTDIEEALASLRQYENNIWVISQVIQNDISSTKVRLFLRKDLSVRYLIPDPVVDYIEEHGLYQEPKASSAKASPSRELEKEFKGKGKASLPPDDAAPSPEENKPTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G0S939</accession>
    <name>G0S939_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0044430</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694835.1">
        <property type="nucleotide sequence ID" value="XM_006694772.1"/>
    </dbReference>
    <dbReference type="GeneID" id="18258481"/>
    <dbReference type="KEGG" id="cthr:CTHT_0044430"/>
    <dbReference type="eggNOG" id="KOG0065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_35_0_1"/>
    <dbReference type="OMA" id="QYWSDQS"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001010">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="513"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="549"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="589"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="623"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="656"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="761"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1179"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1212"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1252"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1291"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1325"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1443"/>
            <end position="1464"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="153"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="842"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="441"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="803"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS19950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1469" mass="164648" checksum="295684F8E4C95BD1" modified="2011-10-19" version="1">MDTKEPVPTEAQPSSSTSSTTARSIEEHIEEARRNNPNGTTRPTGVSVEQAEADFAELQRELSRMSRVSHRCSHAGDNDKALEAGLATSEETFEQFDLEAALRGNLDEERQAGIRPKHLGVYWDGLTVKGIGGSTNYVKTFPDAFIDFFDFITPIKNLLGFGKKGTEVTILNNFKGVCKPGEMILVLGKPGSGCTTFLKTIANQRHGYTGITGEVLYGPFTAEEFRQYRGEALYNQEDDVHHPTLTVEQTLGFALDVKAPAKLPGGMTREQFKEKVITLLLKMFNIEHTRKTIVGNSFVRGVSGGERKRVSIAEMLVSNACILSWDNSTRGLDASTALDFVKSLRIQTNLYKTSTFVSLYQASENIYKLFDKVLVIDEGRQVYFGPASEARAYFEGLGFLPRPRQTTPDYVTGCTDAFEREYQEGRSAENAPHSPETLEAAFKASKYYADLEEEMRQYKENLEKETDKHEDFRVAVCEQKRGGASHKSPYSVGFHQQVWALMKRQFLLKKQDVLALVLSWLRNIIIAIVLGTLYLNLGQTSAAAFSKGGLLFISLLHNVFSSFSELAGTMTGRAVVNKHRAYAFHRPSALWLAQIFVDQVFSATQVLVFSLIVYFMTNLARDAGAFFTFYLLLLSANLCMTLFFRILGCISPDFDYAVKFATVGITLMITTAGYLIQYQSEQVWLRWIYYINPVGLTFASLMQNEFSRSEMTCTAESLIPSGPEYNNINYQVCTLAGSSPGTLKIPGSSYLEKGFSYSKGILWRNWGIVLAIIVFFLLMNIVTGETVRFGMGGNQAKEFQKPNEERKRLNEELRKRREEKMSKAKGEESDSSEINIRSDSILTWEDLCYDVPVPGGTRRLLDHIYGYVKPGQLTALMGASGAGKTTLLDVLAARKNIGVITGDILVDGVKPGKEFQRGTAYAEQLDVHDPTQTVREALRFSADLRQPYDTPQEEKYRYVEEIISLLEMESFADAVIGTPEAGLTVEQRKRVTIGVELAAKPQLLLFLDEPTSGLDSQSAFNIVRFLKKLAAAGQAILCTIHQPNAALFENFDRLLLLKAGGRCVYFGDIGKDACVLRDYLKRHGAEAKDSDNVAEFMLEAIGAGSSPRIGNRDWADIWADSPEFANVKETIRQLKEERRAAGANLNPELEKEYASPFLHQVKVVVRRAMVSHWRSPNYLFTRLFNHVVIALLTGLTFLNLDDSRQSLQYRVFVMFQVTVLPALILSQIEVMYHVKRALFFREQSSKMYSSFVFALSLLVAELPYSILCAVCFFLPLYYIPGLQSESSRAGYQFLIVLITELFSVTLGQALAALSPSLFISSQFDPFIMVTFSLFCGVTIPAPQMPAGYRTWLYQLNPFTRLISGMVVTALHDMPVHCTQHELNSFTAPPGTTCGEYMQPFFERGGAGYLVRNDTTACEYCAYKVGDQFYEPLGLSFDHRWRDMGIYIAFIGSNLIILFLASRFLNYNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9A2</accession>
    <name>G0S9A2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Complex subunit mu-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0045100</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694898.1">
        <property type="nucleotide sequence ID" value="XM_006694835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9A2"/>
    <dbReference type="STRING" id="759272.G0S9A2"/>
    <dbReference type="GeneID" id="18258548"/>
    <dbReference type="KEGG" id="cthr:CTHT_0045100"/>
    <dbReference type="eggNOG" id="KOG2740">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017139_0_0_1"/>
    <dbReference type="OMA" id="LNEMCDG"/>
    <dbReference type="OrthoDB" id="870at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14837">
        <property type="entry name" value="AP3_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="7">
        <location>
            <begin position="187"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="442"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="342"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS20013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="552" mass="58925" checksum="AF1841829750A6C8" modified="2011-10-19" version="1">MNGVIEALHILDEHDTLLLSHTYTSRPLPAAALLPLYLSHPAPRPNLIYLPNVVPPTLVFSLRHGSLTLLLTSSQDIEPLLALEFLHRVVDALEEFLGAPVTSSKIEGSYDIVAQLLTEMCDAGVVSTTEPNALREMVEVEGFLERVLGGVGLNAKTPSSLFPQPPILTPPSAPALPWRRTNVRHTSNELYADLIESLSITLAPSGRPLAAFAHGTIVFTAKVSGIPDIVVTLTSSGGKHALTGLIDLPVFHPCVRLARWKEQPGVLSFVPPDGRFTLAGYEVDLLPLTETTLSSQQQQLKLPVSLDIKTGLGPTGSDFELRLTFNKSFTSTGSVQPGLGRSSHTPTSSSSVSAPSLASFATGTSITSAGSSSSPTLHDLKVTVPLPPAVRNLSEIRPSKGDANFHAAERILEWSINNKELSQLGSVPFMLRCTVVGDLDSGEASVNPEDEMGFPTQSYHGYDPSVTHPPPSSGTPADPGGDAAQKQQQQNKILMPTSASLSFSVRGWLASGLRVESIVLDTRKSRGIGEGVKPYKGVKYLTLSKEGVEVRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9L2</accession>
    <name>G0S9L2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0046290</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695008.1">
        <property type="nucleotide sequence ID" value="XM_006694945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9L2"/>
    <dbReference type="STRING" id="759272.G0S9L2"/>
    <dbReference type="GeneID" id="18258667"/>
    <dbReference type="KEGG" id="cthr:CTHT_0046290"/>
    <dbReference type="eggNOG" id="KOG2164">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011811_1_0_1"/>
    <dbReference type="OMA" id="PRWKKCP"/>
    <dbReference type="OrthoDB" id="302966at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16536">
        <property type="entry name" value="RING-HC_RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039739">
        <property type="entry name" value="MAG2/RNF10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983">
        <property type="entry name" value="RING FINGER 10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="188"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="558"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="640"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="481"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="572"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS20123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="671" mass="74718" checksum="1618DAD5B5AB14EF" modified="2011-10-19" version="1">MSSTSSSPAKPVAGLAATNHPPAPPPTTSSQTFDADRRRNYHPQGPAHPPAAPRKTQGARRQHRNQRRPGARDHIDDEDTLAELRALRNTSSRRGQTSITHLLNIALPPRPHETYHPSYSRSYRRNPSWGVGSGYHAADKARYIHANYRFVVRPTGNYAAQAADADKHIEWDDVLQVIASAESQQAACPICLSEPVAPRMAKCGHIFCLPCLIRFMNTTPPDHPPDKKPQNRWRKCPICDDSVYLTDVRPVRFYAGQECPLPRVGDDVILRLMMRRANNTLALPREGAAEVLQSAVDDVPWHFAANVMDYARIMKGTSGYMEEQYDREIEDLTRQEQEDELLYHEDNEWTQRAIKSVKAAKEKLAELGDTGKDPQPMTAGQTSELSKQPSADQEFYFYTSPPHLYLSPLDIRILKTRYGTFSAFPSTLLPRVEHISMGHVVDDALRKRAKYLSHLPRGCLISFLECDWTDIVPNEILEGFKDEIEKRRRRNREKALQEERERIQAERAEAAALRNARRLASFSGDDDGPVTIKWGDADEDRPPVDPNDFVPLSAVVSTSPSQRPGFSALADMNTSPEGSSTTGAGQLRRTTVWGTPAVDGPPLETLPPQQKVDDGWLDDSEVLKSLGEADLAVQLEALGIESAGPSNSGGGGKRKKRQKITLMSTGGRRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9Q2</accession>
    <name>G0S9Q2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Actin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0046700</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin family. ARP6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695048.1">
        <property type="nucleotide sequence ID" value="XM_006694985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9Q2"/>
    <dbReference type="STRING" id="759272.G0S9Q2"/>
    <dbReference type="GeneID" id="18258708"/>
    <dbReference type="KEGG" id="cthr:CTHT_0046700"/>
    <dbReference type="eggNOG" id="KOG0680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027965_1_1_1"/>
    <dbReference type="OMA" id="FFEEYEC"/>
    <dbReference type="OrthoDB" id="6220758at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10210">
        <property type="entry name" value="ASKHA_NBD_Arp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000040">
        <property type="entry name" value="Actin-like protein ARP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS20163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="422" mass="47206" checksum="42C30BC213EED30F" modified="2011-10-19" version="1">MAGGSRKSRSVAGGPAAPSTTLVLDNGADTIKAGLIPTGSSGGDDNTPTQLQPRIIPNCIARDRHKKIYVASELDKCRDFGEMAFRRPVEKGYIVNWEAQKEIWEREFFDEKAPLRCDPAETRLVLAEQPNALPALQTHCDQMNMPVTLPAEIMLLIDSGYSHTTITPLLQGRPLHPAIRRLDVGGKLMTNYLTRLISMRHFDMRNETYVVNEMKEAACYVSLDFKGDLEKTWKGTRDEKRKDWLTGAGIAKDYVLPDSHTRFHGVLRDYDPNASRARRGIPNTEDVLTLRNERFVVPELLFHPSDIGLRQPGLADLIMQSLSVLPIGLWPGLLANVVVVGGNAKFENFIQRLQMELLERVPTECVVRVARPENPIISTWLGASNFARHEHVERLAVTKQQYEEYGAGWVARKFAAGLGVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9W2</accession>
    <name>G0S9W2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0047390</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695108.1">
        <property type="nucleotide sequence ID" value="XM_006695045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9W2"/>
    <dbReference type="STRING" id="759272.G0S9W2"/>
    <dbReference type="GeneID" id="18258777"/>
    <dbReference type="KEGG" id="cthr:CTHT_0047390"/>
    <dbReference type="eggNOG" id="ENOG502RIWR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1366100_0_0_1"/>
    <dbReference type="OrthoDB" id="4590859at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS20223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="200" mass="20464" checksum="ACB2F6EF1C92A06E" modified="2011-10-19" version="1">MPDGMDHNLLGGSAAIDGASGTAAGVAASAAGAAVASSAYHRDLPSPSPVQPMQQAPVSRPLVVPIVPTRPDNRRISVFTSDTGMTGSAFTPSSVSPNSTNFNMLPVPGMARTAKPQQAPPDPPVGRSANARFSVDSMSSVSTSSCVTAALSPGQMAWPMPPGTPPAIRHPGGPQYIDFEQTGRTVVRINLPPCGHRPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9X5</accession>
    <name>G0S9X5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0047520</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695121.1">
        <property type="nucleotide sequence ID" value="XM_006695058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9X5"/>
    <dbReference type="MEROPS" id="S08.061"/>
    <dbReference type="GeneID" id="18258790"/>
    <dbReference type="KEGG" id="cthr:CTHT_0047520"/>
    <dbReference type="eggNOG" id="KOG1153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011263_1_4_1"/>
    <dbReference type="OMA" id="DWITANH"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000014">
        <property type="entry name" value="Proteinase K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF58">
        <property type="entry name" value="ALKALINE PROTEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Inhibitor I9" evidence="9">
        <location>
            <begin position="32"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="8">
        <location>
            <begin position="139"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS20236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="393" mass="41301" checksum="E39C569ED34B6EB0" modified="2011-10-19" version="1">MHLAWTAFLPLALAAPVIQPHSFNLQLIPERYIVKLRDGVSEAALEKAIKEAEPAGPPQQVYRAKRFKGFAGRLTPKVLEKVKSLPEVEYIEQDAIVTIAEYVTQSDVPWGLARISHREKGHTTYVYDETAGEGTCAYIIDTGIYVEHEQFGSRATFLANFIDSTTTDGNGHGTHVAGTIGGSDVGVAKKTLLFGVKVLNDGGSGTLSGVIAGINFVADDAVNRTASGQCPKGVVANLSLGGGRSTAVNAAAAAAVEKGVFLSVAAGNSNDDAYWYSPASEETVCTVGATDVEDHRAWFSNYGTVVDVFAPGVDILSSWIGSPNATATISGTSMAAPHVAGLAAYLMGLDRPKETLELCQYIRDTATKGVISGLPSGTFNGIAFNGNAEEAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9X6</accession>
    <name>G0S9X6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0047530</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695122.1">
        <property type="nucleotide sequence ID" value="XM_006695059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9X6"/>
    <dbReference type="GeneID" id="18258791"/>
    <dbReference type="KEGG" id="cthr:CTHT_0047530"/>
    <dbReference type="HOGENOM" id="CLU_412182_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="361"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="666" mass="71824" checksum="5A68FA8753511473" modified="2011-10-19" version="1">MLPNATKQSDTDLRTRDATVPTTPEQQRGGLPAWALEIKHPEGDACREIQAIRRASLSNNRSRMSNSPSVGSPCGVAGAATGSAKRVAVVGRLKTGSVEKPFFTYPVTKADQACCPVHAARKADQDDDNDDSSSDESILALIAAIRQNKRCNIGFSPSPGPVNPGIEAFTHLVQSSPLPSHKSNPSQGLPPLALTEINGQATLFTPREPLFPSSPSLPISMSISSAVHWSSPRFDNVSRRLFTAKEFSGSSPPEFRRSGIHLRENPDKMDVNKESSGPDNRANEIHVSTGMRIHFTGGVATVQLSQPEQSQISRAQDQVAQLAVVSSNQQWANIQTQPAQTPSVAAQVKQPIHAVDDQTVQAAQPAALPVQDPQSASENKDTDKEFDNNTTGEEPADVVEEDEEYNPAIDILLADIRNLQCSEAYKIPRAILTAAAQLAPLKDGTDKLDAEAQVLDFNPNLDDANHLIAAQNLLNKRSVHPDQLPLADLGPETFNDPNFFNSLPIGLPLPDLPAAQASQKAGLTLGDPSVLDQLEPIHVDLLSLLSPDNLDQPMIDLEEAVQGNKYPVIMDPAKGHGYVWLPRDKEGRSEPGWRKWPWDPLLPPVLGQGCAPTGAVALPHPCNADSALPFYMQALFYGQSINNKLFDSTVTRLNNLREVVGASAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9Z3</accession>
    <name>G0S9Z3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0040420</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694450.1">
        <property type="nucleotide sequence ID" value="XM_006694387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9Z3"/>
    <dbReference type="GeneID" id="18258080"/>
    <dbReference type="KEGG" id="cthr:CTHT_0040420"/>
    <dbReference type="HOGENOM" id="CLU_1695273_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS19565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="17694" checksum="1E695CA8123E3C24" modified="2011-10-19" version="1">MRYRNGGSLMNMAQAYCEHNKFDINNPNELADCGREVLHSSLIYYFIRAILRGLAVLHEGYVSDSNFAQHNEGDITRPELMNGNMYSLQQLQALYDRLLPPASRFTQGNLTLPVNLCKQTLIWDPIMHTDLHACNIQGHYSIATDKYLDPDTFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G0SA83</accession>
    <name>G0SA83_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative Ap-1-like transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0041340</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the bZIP family. YAP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694540.1">
        <property type="nucleotide sequence ID" value="XM_006694477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SA83"/>
    <dbReference type="STRING" id="759272.G0SA83"/>
    <dbReference type="GeneID" id="18258172"/>
    <dbReference type="KEGG" id="cthr:CTHT_0041340"/>
    <dbReference type="eggNOG" id="ENOG502RPD7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011807_0_0_1"/>
    <dbReference type="OMA" id="LNMACGN"/>
    <dbReference type="OrthoDB" id="5380163at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000067">
        <property type="entry name" value="BZIP transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.100">
        <property type="entry name" value="YAP1 redox domain. Chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013910">
        <property type="entry name" value="TF_PAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023167">
        <property type="entry name" value="Yap1_redox_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF6">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08601">
        <property type="entry name" value="PAP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111430">
        <property type="entry name" value="YAP1 redox domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="147"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="80"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="257"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="554"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="260"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="286"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS19655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="611" mass="66162" checksum="78F1F9318A12DDBD" modified="2011-10-19" version="1">MTSTHNPLENLILTPHQQQLLFAALNSNRPTSRPNSAMFQTPLNSMSMPGVDGLGTFQTTPGFGFDYDFSAHDTSFDFSFDDGTQHTAPTTAPAPPANKAPSKPESTENDSPEKRSRPDDGEGDNAAKRRESQEKVHKKPGRKPLTDEPSSKRKAQNRAAQRAFRERKERHLRELENKVQELTKLSEAANNENQALRAQVERLTVELNEYKKRLSLLSSGRPAHQGPATPFGHMFVNNLNDINFQFEFPKFGSLPGPPVINTTKKPTPVTTQDANGYQADKAQDGISPTTQSSSGQIRQDPQLSGQLTSLNTQHGQQLSNGNAARGSVNSLDSPSNQNGTSTSSPSASSSSQAGGANSSCGTSPEPLTHSPMSSRPGDALPAIGEEQPSLGTSLTGFGHFDASGDDFSKWLPQPDFQFDPHLFGDYRESQEGLFSSTFDDSFFNDALDVDFITPYNLPLSGMGQQQPTAPKKDLIAEIDAAKDADELPTTTGGPELNCSKIWERLQNCPKVQSGDFDLDGLCADLQKKARCNGHGAVVAEKDFDQVIQKWLCKDKDGKKDSSGSSNSQQNGDKEMGSRCAEMVTAAVKEAVNEAREQCKQANAAQNQQASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAM5</accession>
    <name>G0SAM5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Seipin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0042810</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694682.1">
        <property type="nucleotide sequence ID" value="XM_006694619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAM5"/>
    <dbReference type="STRING" id="759272.G0SAM5"/>
    <dbReference type="GeneID" id="18258319"/>
    <dbReference type="KEGG" id="cthr:CTHT_0042810"/>
    <dbReference type="eggNOG" id="KOG4200">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_496951_0_0_1"/>
    <dbReference type="OMA" id="FRWWRTA"/>
    <dbReference type="OrthoDB" id="3990054at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23995">
        <property type="entry name" value="Seipin_BSCL2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009617">
        <property type="entry name" value="Seipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212">
        <property type="entry name" value="BERNARDINELLI-SEIP CONGENITAL LIPODYSTROPHY 2 HOMOLOG BSCL2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212:SF0">
        <property type="entry name" value="SEIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06775">
        <property type="entry name" value="Seipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="368"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="409"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="465"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS19797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="548" mass="60150" checksum="FC63E48E42A66A84" modified="2011-10-19" version="1">MPPFSLQGPDPRRHHLDLFNNPIFSHAANIPGSYYHQQHMIDDDNKSAPPGGIQSYISRFIDKTVAFISSDGFKKGVLLTVLCITALTLLFPAAGLYIVFYNKYMPAQVTTVPVHLQYGYGPNPFGIAPIEPPKRVYKHLSYDITVSLTLPRSPSNLNRGNFMLALHLLTPTNPSATKKTNPAQQLPYVTFSPPPPSENPSASSLAVHYQPTRIDMPTFLSKHHILYTVTRPALVPYFDPLTSLASRLFFLFYHVLFPDTSSTVRLDVPMAEHLPLSFPWPPDNPDAKAPEPTTLLLEVQAGQGLQVYQASVTFTARLRGLRWFMFRWWRTAFVLGTGLIWALEVLSLCIPFGYAWALVGDDVKGDKEEQEASKRPRISKALLPKGPSSSSGSSVSKPALPEPSGPSRGRSRKRSRGRRRGAKQEGSSSPATKSGISSPSSSVSGSRIKGKGKQKGESNSDTEEGFSKLHTPSDTDIKEEEDDKALLASLPEYRPTEGVGSGSLREEEGEEREGSDREEPIVATSSSHEATGGQARRRNVSGEAVETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAY8</accession>
    <name>G0SAY8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0048270</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695190.1">
        <property type="nucleotide sequence ID" value="XM_006695127.1"/>
    </dbReference>
    <dbReference type="GeneID" id="18258865"/>
    <dbReference type="KEGG" id="cthr:CTHT_0048270"/>
    <dbReference type="eggNOG" id="ENOG502SACR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026944_1_0_1"/>
    <dbReference type="OMA" id="SRDDHEP"/>
    <dbReference type="OrthoDB" id="10249419at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35006:SF3">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G06020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35006">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14830)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="575"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="584" mass="66317" checksum="B0FA9F8B978B183D" modified="2011-10-19" version="1">MAPYLEVSHLPSASSFYSAIIQPLGLHYHTTEDGNYPAISFGISPRAPPYFKIIQVFPTRERPLKRGRIVLGCPSATAIDQTYERAVQVTADAWAAYERHLPEGYTAPGAPSVRRYPTRVGAVCLEIFDFDGNMSQIVYVPPPDYPPDYDGSTLRRTKVTDEQATRILDWSYEIADTERKADLERDMDSDSTESPRTRSRRSYSVRHPEDERDDRRLSRKRSLKRRSSIYDPATSAREDEEELEGSYRMSKSSRRRSSRHEYDYDEDAPAYSPRSPYADYHDDDREERVIEVERSIEKVRHPGDYAALANFRRPLPEVMARYSQVGSSRSPRDDDDLYDEYRRGRHSSSRSRHSRTRSEAAAQREPYPPELEHRSYVSLRSSRYPPPVQRTYTYDLPPERDGSYFGRSHRSVSTLRAEATMPPPPPPLPTDPYFLSSRSSHHRSYSSREGSYTSASRGIAPPPPAGYYPPPPXXXXXXXXXXXXXXXXXXXXXXXLRLRLETTTPAPAPPPPAAAGYYPAPRDYPPLGSAAVPGYPMPGRHAPLPLSGHRRSKSRTRGRYESSEDEMNDDDSIVPDDSISCVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBN3</accession>
    <name>G0SBN3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0054190</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695754.1">
        <property type="nucleotide sequence ID" value="XM_006695691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBN3"/>
    <dbReference type="EMDB" id="EMD-15397"/>
    <dbReference type="STRING" id="759272.G0SBN3"/>
    <dbReference type="MEROPS" id="T01.P02"/>
    <dbReference type="GeneID" id="18259457"/>
    <dbReference type="KEGG" id="cthr:CTHT_0054190"/>
    <dbReference type="eggNOG" id="KOG0180">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_10_0_1"/>
    <dbReference type="OMA" id="CSEQLYG"/>
    <dbReference type="OrthoDB" id="204949at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03759">
        <property type="entry name" value="proteasome_beta_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000003">
        <property type="entry name" value="Proteasome subunit beta type-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033811">
        <property type="entry name" value="Proteasome_beta_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF10">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS18809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="206" mass="22734" checksum="34926D64830B5E24" modified="2011-10-19" version="1">MSSPFSINGGACVAMVGKNCVAIACDLRLGLQALTVSNNFPKIFQYGDHVFLGLTGLATDVQTVADIFRYKVNLYRLREERHIAPRTFANLVSSSLYERRFGPWFVSPVVAGLDPKTGEPFICGFDSIGCIDFAKDFIVSGTATEQLFGMCESLWEPDLGPEELFETISQALLNAVDRDALSGWGAHVYIIEKDKVTKRLLKGRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBP6</accession>
    <name>G0SBP6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ADP-ribosylation factor GTPase-activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0054320</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase-activating protein for the ADP ribosylation factor family.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695767.1">
        <property type="nucleotide sequence ID" value="XM_006695704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBP6"/>
    <dbReference type="STRING" id="759272.G0SBP6"/>
    <dbReference type="GeneID" id="18259470"/>
    <dbReference type="KEGG" id="cthr:CTHT_0054320"/>
    <dbReference type="eggNOG" id="KOG0521">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002728_0_0_1"/>
    <dbReference type="OMA" id="ITPNAFP"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08204">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07608">
        <property type="entry name" value="BAR_ArfGAP_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000051">
        <property type="entry name" value="ARF GTPase activator (Csx2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000252">
        <property type="entry name" value="ARF GTPase activator (Csx2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000017">
        <property type="entry name" value="ARF GTPase activator (Csx2), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045258">
        <property type="entry name" value="ACAP1/2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180:SF160">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN EFFECTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180">
        <property type="entry name" value="CENTAURIN/ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="8">
        <location>
            <begin position="567"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="Arf-GAP" evidence="9">
        <location>
            <begin position="744"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="197"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="458"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="710"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="924"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1019"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="252"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="710"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="938"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1019"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1030"/>
            <end position="1040"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS18822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1058" mass="117238" checksum="C063728A6AA75B44" modified="2011-10-19" version="1">MGNVSSVPDEGAALYLKDQNRCPHFLLKLTNDEDLSITFSFVIRRQQALPTPAGVEVKPPPDTQINGLTFVFASNAREIENLLTREFHADPNLHKNANVSLIGTYSTEGHPSVTFDWTWKWKPPKPAEDRGGGWRTACSIVEYDQRNHRFITLASFTLYVANTASYISHPNSPTPPLLTAPPKLRAVSAQSLESHIGTIPEQDESTMLPPPSRDLPSNPPPPPPEPIKIDISCPRPGDDLLFDDGPVFRATIKALEQKTGNMRQQMKRMIKKAEQVYEAQQEANNAFAAFMEGLREVSATNRNAVQPAIEHYFDKIAREILLYERQNTANIQNFIIDPVTKLYQMDIKQAEAKKRDFEEESKEYYAYVSRYLGQRSDSVKAKQSDSKYQTKRKNFELKRFDYSSFMQDLSGGRKEQEILSHLTKYADAQARLFLSTAKKVDALLPQLEALSTEVQEADKEYQYQRREREEKRRQLEKGTLSLSDLEFHSGTGYVNGHHGGDHDPGRADGTGLGLKHSRSLNAGSSAHDPSRSPGDIGSPQQNAKFKGIRDLEERDPNQAAHAGKDAPNRKEGLLWALNRPGGHVDPRNLNKQGWHKFWIVLDQGKLSEYSNWKQRLDLHMEPIDLRLASVREARNAERRFCFEVITPQFKRVYQATSEEDMNSWITAINNALQSAVEGRAYKEKPATAHGDSPTNGKDFGAVLMGKSPSVGHGSHGSSGLPFRRTTVGARPSTSRGGSFEERPDKLLQMLREADQGNTWCADCGSSNKVEWVSLNLGIIVCIECSGIHRSLGTHISKIRSLTLDTTSFTPDIVELLLIVGNRVSNMVFEAKLEPAAKLAPHSTREQRLKFITAKYVDRAWVEPISPTLSRFATAEETLLAAIKKNEIQQIVYALALKANPNCTDKVRGTHAVYLALAAADPAPPSPLVAQQQNTSQPTTSHHSAAATVTDRTVPFPVAELLIQNGAEIPDAPPPVPLSIAAQAYLEMKRGRKAAIEASGSSALAGYYEPTSSISSIASTATTQTTATATGDKHKEREARLQKRVSAGGKLAKSPIPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0SC12</accession>
    <name>G0SC12_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0055510</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695883.1">
        <property type="nucleotide sequence ID" value="XM_006695820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SC12"/>
    <dbReference type="GeneID" id="18259589"/>
    <dbReference type="KEGG" id="cthr:CTHT_0055510"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_12_1_1"/>
    <dbReference type="OMA" id="AIMCIVP"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF36">
        <property type="entry name" value="PROLINE-SPECIFIC PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="479"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="43"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS18938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="545" mass="59681" checksum="4C4B18A0C0D10650" modified="2011-10-19" version="1">MKTETASTDSPGAIEAQGTNNILDSLASLDRDSQLQRGLKSRHIQFLALGGAIGTGLFVGSGGILAIVGPVPLWLGYLFMMFLVWIVMNCIAEMTTYLPMKGITIPYFTDRYVDRSLAFALGWNYWYAYTFLVAAEVSAGAILLEYWDTPVPTAVWITIILAVCLLLNIIAVEIFGEAEFWFASIKLITIIGLIIVGIVIMAGGAPEGGAVGFKYWKDPGAWQEYVGRGSTGRFTAFWTAVVRAGFSFITSPELIGTAAGESVAPRRNIPKAAGRFLVRLAIFYGVSSLIVGALVPSNDPRLLSPESNANASPWVIGIQRAGIKGLNHVINAAILTSAWSAGNAFLYSGSRILYSMAAIGQAPSIFTRTSHRGVPYAAILGTWGVALLSYLNVSENGARVFGWFMNLSTISGFIGWIVVMVTYLRFRSALSFQGLLHTLPYKTIAQPYATYFVLFLVSALTLTNGFQVFAKGRWNVEDFLAAYITIPFFLVLYMGHKLRCRGPVVKPVSEIDVITGKKEMDEFCEMDHIVPEPKNIVQRIWFWLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0SC58</accession>
    <name>G0SC58_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0056020</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.3.2.9" evidence="1"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695929.1">
        <property type="nucleotide sequence ID" value="XM_006695866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SC58"/>
    <dbReference type="STRING" id="759272.G0SC58"/>
    <dbReference type="GeneID" id="18259640"/>
    <dbReference type="KEGG" id="cthr:CTHT_0056020"/>
    <dbReference type="eggNOG" id="ENOG502S329">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030506_2_0_1"/>
    <dbReference type="OMA" id="PEEYINY"/>
    <dbReference type="OrthoDB" id="2017317at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017939">
        <property type="entry name" value="G-Glutamylcylcotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935:SF0">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="82"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS18984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="343" mass="37803" checksum="9DFA1B0BE9E7C1C0" modified="2011-10-19" version="1">MTVAEPRRNGAPHALGHGNEANGGSKKGGSTPAYPPISSIPSTPAARLDEPDARPSPFPKEPILAKDFHPKDGVPVPATILYFAYGSNMCAKSFLGVRGVRPLSRINVCAPALDLVFNLPGVPYLEPCFANTAIRQVPAKPPVPPVNTTTDDDHHPIDPIWTKGVYGIVYEVTPSDWATIVATEGAVRKIGHAQPSLRYLNLLRTGAKEHSLPDEYQAYLNALRPYTVTTRRQRWGRILFLGFWAPLVMLMLVSGKIFADEKGRAPGWLARVMGVVVNAVWLSYDYVAKPIFGEGERTIEHKMNGRWEEIKTKRRRKSFASGLRGREEAVDEEKRVLLEGHSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCD0</accession>
    <name>G0SCD0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="8">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0056780</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="8"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696001.1">
        <property type="nucleotide sequence ID" value="XM_006695938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCD0"/>
    <dbReference type="STRING" id="759272.G0SCD0"/>
    <dbReference type="GeneID" id="18259716"/>
    <dbReference type="KEGG" id="cthr:CTHT_0056780"/>
    <dbReference type="eggNOG" id="KOG2867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030733_0_0_1"/>
    <dbReference type="OMA" id="SWIKINA"/>
    <dbReference type="OrthoDB" id="16120at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1150:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016325">
        <property type="entry name" value="Phstyr_phstse_ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0697">Rotamase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS19056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="468" mass="52533" checksum="5B9DE900337F8161" modified="2011-10-19" version="1">MPSSANTSPPDQGAKEAQGRVPSAGQPQAPQQPSQQSQYSSSNPSPGIPNLRDKIPKLEPRRRKKPEPENPMPVPETPEPPPKPDLSTLTFTVPVRRILSPDDHKLFLSSPTYKLILSFIFQLSESVRDKPISSVQDADFTPTLRAILTILDEAESLCRATPPEDQGGSRFGNKAFRLFVDKVRAAAPQWHSTLFTSPSPLPPASVPELSTYLTHSFGNRTRIDYGSGHELNFFMWLLCLDRLSLLSSPDYPALVLRIFPRYLNLMRLVQLTYYLEPAGSHGVWGLDDYQFLPFLFGASQLLHHPFITPRAIHQELTLEEFGHEFLYLNQVSFVNSTKTVKGLRWHSPMLDDISSAKNWGKIEAGMRRMFVNEVLGKLPVMQHFLFGALIPAAEGMSEPVLKKEGEGEEDEDLEGEVKVFDDKEGRRHVHQPNGWSDCCGIKVPSSVGAIGEMRKRGMMDQLRRIPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCZ1</accession>
    <name>G0SCZ1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mannose-P-dolichol utilization defect 1 protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0058880</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the MPDU1 (TC 2.A.43.3) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696207.1">
        <property type="nucleotide sequence ID" value="XM_006696144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCZ1"/>
    <dbReference type="STRING" id="759272.G0SCZ1"/>
    <dbReference type="GeneID" id="18259926"/>
    <dbReference type="KEGG" id="cthr:CTHT_0058880"/>
    <dbReference type="eggNOG" id="KOG3211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053568_0_1_1"/>
    <dbReference type="OMA" id="LQVLYYW"/>
    <dbReference type="OrthoDB" id="271506at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000006">
        <property type="entry name" value="mannose-P-dolichol utilization defect 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016817">
        <property type="entry name" value="MannP-dilichol_defect-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 LEC35 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226:SF2">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023381">
        <property type="entry name" value="MannP-dilichol_defect-1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="253"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR023381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS19262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="299" mass="31899" checksum="DEBA2461FDAEBEC5" modified="2011-10-19" version="1">MADLLRSALQPITHNFPAPIRDLGISLIGDSCYKALLLDVDLENTECLKLAISKALGIGIVGASAVVKVPQIIKLVQSRSASGISFLSYLLETSSYLISLAYNFRNRFPFSTYGETALVLGQNVIITVLVLNYSGRASMAALFVAVFAAAVATLFSEGVLDMQKLSYLQVGGGMLSVASKVPQIVAIWQQGSTGQLSAFAVFNYLLGSLARVFTTLQEVDDKLILYGFLAGFVLNLILALQMVYYWNAPTPQAKGKKKEAPLKQTASVAPAAATSSAADIPRASTPTPKSKGPTTRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G0SD72</accession>
    <name>G0SD72_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0059180</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696237.1">
        <property type="nucleotide sequence ID" value="XM_006696174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SD72"/>
    <dbReference type="STRING" id="759272.G0SD72"/>
    <dbReference type="GeneID" id="18259956"/>
    <dbReference type="KEGG" id="cthr:CTHT_0059180"/>
    <dbReference type="eggNOG" id="ENOG502RAX3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_289835_0_0_1"/>
    <dbReference type="OMA" id="RFEFRDS"/>
    <dbReference type="OrthoDB" id="5353066at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1040"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1084"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="872"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="875"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS19292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1114" mass="121449" checksum="E6AFFB7DDC878DDB" modified="2011-10-19" version="1">MADKGCSVQHRNGRSPYDNQTDESTTGKSSVTLAAVRPTHQRTITPKGTLFTNLGEAHQAITAKAASRSAGITSPETAIDPFETASTISTQSESTISTGVTRKLPVPKGPRPMQQRVPTPFHSPSLTQTAIEKLPPVPAIATVHDFRSTGNNDLVKDKPSHETETSAVVSSSDSDSTVGKIYSQYLPSSSVEPSSSIGGAEKSFMELKTAPEVIQSSTVAQEKSEPAAKEKAAPVTQTPQTKRRNIPSTVRSSKTQQKIWSPPGEPPKIPLPEIPTKRKSARNPSTGANTRISQASAHQLATPSSKSEGVLKALARESKSSKLVASLTYSDSFTSSPKPHIQQSTTSRLVPNMKDNDKRQSAAVNKTMSSTKVPEGSLHSESNTLANDKHKSSAVADNKDSKQETQGHLCIDPSNLSTLNHLIPPDLSTAAISTDSEEDPFKYDNIKLTRNREREVSMALRCLSGMSTASINCNFGSSSPFVNLQSSSPFADVQTSSPLTPLTPPCAANEQPQTANQKDHSINPFTAKLQYYKAPEVRYNWDEFGEPNEVEVKVTIRPPPTPCVEEDLKDSNKLPPPPPNTPVLVPDPQSSMSQSKLTRESRTARHQTIFSDGADWETVPDSIGQFDSNRAIASSSYLTESQIGKPTGSSIADYSDDDSDVQTAREGIYSSTDRILPQPPPSVRTHPRYPRLSETERPIFVPKPRIHKVNGYLNPARLFTDPTTTASSANTTRSNFVDKISNSIRSCGFGKRDESRHPYQNLEGSGDLGSLNSFFSCEMEPLKAKSQTGNGDAAHTSGKPLVSQAEINLGYKEKVDKWKLETPSLGLSTTTGNKVGFASTEHRKSVDARSPTQFAFPLISLEEAARREAIKRSTENSALKSTTESKMNTATANPNDIQKSVATISRPQPVHKRALIGNSAMAVGNMYINDSQEALLRPANGSADAAITNRKKPTVPARLIPSYSTRSVLETVCPSLTGRASPHARYAFPEAPRLVAREERNRYRDMNMTTDQPEIAALEGRDYASDIYLSWDARRRRRNYFYVLCFLSVLPFMFPLVYKGIMDAPLGWVTLGETGSFSRRQRRILTWIGLSSSAIWLIVLSSVIGWGLAHATNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDA7</accession>
    <name>G0SDA7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Transcription elongation factor Spt6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0051100</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Histone H3-H4 chaperone that plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression. Essential for viability.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the SPT6 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695453.1">
        <property type="nucleotide sequence ID" value="XM_006695390.1"/>
    </dbReference>
    <dbReference type="SMR" id="G0SDA7"/>
    <dbReference type="STRING" id="759272.G0SDA7"/>
    <dbReference type="GeneID" id="18259148"/>
    <dbReference type="KEGG" id="cthr:CTHT_0051100"/>
    <dbReference type="eggNOG" id="KOG1856">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001680_0_1_1"/>
    <dbReference type="OMA" id="GYFYLCF"/>
    <dbReference type="OrthoDB" id="995477at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09928">
        <property type="entry name" value="SH2_Cterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09918">
        <property type="entry name" value="SH2_Nterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2740:FF:000002">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.650:FF:000004">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.850:FF:000001">
        <property type="entry name" value="Transcription elongation factor spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.140:FF:000007">
        <property type="entry name" value="Transcription elongation factor SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000056">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000065">
        <property type="entry name" value="Transcription elongation factor SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2740">
        <property type="entry name" value="Spt6, Death-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.850">
        <property type="entry name" value="Spt6, helix-hairpin-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="entry name" value="YqgF/RNase H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041692">
        <property type="entry name" value="HHH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049540">
        <property type="entry name" value="Spt6-like_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028083">
        <property type="entry name" value="Spt6_acidic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042066">
        <property type="entry name" value="Spt6_death-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032706">
        <property type="entry name" value="Spt6_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028088">
        <property type="entry name" value="Spt6_HTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035420">
        <property type="entry name" value="Spt6_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035018">
        <property type="entry name" value="Spt6_SH2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035019">
        <property type="entry name" value="Spt6_SH2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028231">
        <property type="entry name" value="Spt6_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055179">
        <property type="entry name" value="Tex-like_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017072">
        <property type="entry name" value="TF_Spt6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145:SF6">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14635">
        <property type="entry name" value="HHH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17674">
        <property type="entry name" value="HHH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14641">
        <property type="entry name" value="HTH_44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14633">
        <property type="entry name" value="SH2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14632">
        <property type="entry name" value="SPT6_acidic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21710">
        <property type="entry name" value="Spt6_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22706">
        <property type="entry name" value="Tex_central_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14639">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036947">
        <property type="entry name" value="Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158832">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="1103"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR036947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS18508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1415" mass="164719" checksum="246FD4C9D5CA89B7" modified="2011-10-19" version="1">MSDEEMRDLIDGEAELNEENDEPVDDEAGEAVGDEDGEDEEAALIDSSEEEEDDEDEEEARRIREGFIVDEDEEEEEEEDEEEKERRKKKKRRIREEEEQLDEEDLDLIGEATQQWERPRPEPKFKRLKRGHRAESRGSERRGLAEIFSDDEDDETEEQRYSRSHRAVVDEFDDFIEDDYPEDDQERMQREQEDKEVARPRDRLVVDTTGLDKDALDDMEAIFGNGEDYDWALQMEEEEEEREREEQAIELKDVFEPAQLKEKLLTDEDNQIRIIDEPERFQIDRKPFKEQPTSAEYFKEEARWITNLIWPKKNLRADLHGPFNKAVGKVLEFFIIDGVEVPYIFQHRRDYLIHARKIRNKSDNPDSQEYTLDAEKLLNQDDLWRILELDLKFRSLVEKRNSLEKAYNNLKEGAGIQDSILDEMIHQAATIEELQDLQDYLNFQYSSQIKAIAAAGNGETREIKRPGAKTAFFERIRRSKAYEFVKALGISPDRLAQNALREGKKVSSDDPSQRPVELADSLCDLEFPSADQVINAARQMYAEEMFVSPRMRKHFRIQYYQMGSVSCRRTEKGLRKIDESHPYYEIKYLLNQTIRDLAMRPEIFLKMMKAEEEGLVEVRLSLENEREFRKQLYNEFISDNFSELADAWNAERQKVLDLAFGKLEKVIAKGVKDSLRTACQEELLKTCREEYFKRLDQAPLKPKGMVLGTTPRVLTLTNGMGDPNRDPIYWTWVEEDGRIVEHGKFVNLARDENQREAFAELCRRRHPDAIGVSGFSVDTHRLIKDIEGIINEKGLMGPEYQDPDSDEYRSDLLDVIIVNDEVARLYKDSPRAQQEHPTLNPLTRYCYALARYMQNPMKEYAALGKDVVSLRIHPYQQYLPQDKLLKAMETAMVDIVNLVGVDINEAMNDPYTANLLPYVAGLGPRKAQLLIKGINANGGVVTSRDELVGDPERHKIPVLGPRVWNNCASFLYIEYDSSNPESDPLDNTRIHPEDYDLARKVAADALGLDEEDVKAETDEHGPGAIVSKLFREEEQDKVNELILDEYADQLEREYQQRKRATLEAIRAELVGPFEELRKGFAIPSTDQIFTMFTGETRDSLCEGMIVPVNVRVVKDDFAIVRLDCGIEGRIEAHEVSYRHSIKDLLSVNQTVQAKILDINRKDFTCKLSLREEELRRPFRRHYDYGRGQWDYKQEDLDREELREKDKVTGRTQRVIRHPLFKPFNSVQAEEYLGGMPPGEVVIRPSSKGNDHLAVTWKVADGVYQHIDVLELQKDNEFSVGKVLRVGSKYTYSDLDELIVEHVKAMAKKVEEMMQHEKFQKGSRADLEKWLTTYIDANPNRSTYAFCIDPKHPGYFYLCFKASRTSRVNAWMVRVVPHAFEMMKSQYPDMRALCNGFKLRYQSEMLKAQQQGHVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDI9</accession>
    <name>G0SDI9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyltransferase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0051950</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695535.1">
        <property type="nucleotide sequence ID" value="XM_006695472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDI9"/>
    <dbReference type="STRING" id="759272.G0SDI9"/>
    <dbReference type="GeneID" id="18259233"/>
    <dbReference type="KEGG" id="cthr:CTHT_0051950"/>
    <dbReference type="eggNOG" id="ENOG502RYMZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005679_13_5_1"/>
    <dbReference type="OMA" id="GAYEWTR"/>
    <dbReference type="OrthoDB" id="5819582at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF134">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="313"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="597"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="3">
        <location>
            <begin position="126"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="3">
        <location>
            <begin position="525"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS18590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="645" mass="72963" checksum="A0FC2F2117A45278" modified="2011-10-19" version="1">MPLLFLGDRSGSSSGPSETNDANYVASELDRIESQKHERKALLRGSDNHILTGDNDREEVIAQALEPQLQQILRTTRRIMRQIRSLIIRLLIFFIPSFLQDRFTGRHGSSSSSHVNSTNNNLGPTAYLDGIRGVAALFVFFCHLLYTCFEIAPGYGTSGDHYNPLLLPFVRLWFSGPPMVCVFFVVSGYALSLRPLKLLRSKRWGEFAGTMASLAFRRFFRLFLPTAISTLSVVFLVRIGAYEWTRDFAYDEFIMRNVQEIHYDRRPTTREQLVEWAWAMFNFIHIWDWDAFGGSTKIDVHLWTIPVEFRASMMLFMTIIATSRLRTGARFAVVGAIMLFAYRASRWEMMLFYVGMLLAELDLIRGIHDPAPAPAPAPTSLLSSSISLAPTPYPTPNISRAHSPLSFTLKPASSSSVLCLPALKQEEPEHQLKEAEEAKPQPSSPPRRRNPNPYTSFPQSLIWPSISILALYLMSQPDIGSDETPGYETLVHLLIPCWWGIDVSDPDRSDEALHGNCREAARNHYRYLQSLGAALFVAAAARCAWWQRNVFESPVAQYLGRISYAVYLCHGPVMHTLGYAVERWVWRLTGTQTTGRYVGGFVVACGIVVPLVLWVSDVFWRVVDVQCVKFAKWLEGKCTIDEGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDM3</accession>
    <name>G0SDM3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deoxycytidylate deaminase</fullName>
            <ecNumber evidence="7">3.5.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">dCMP deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0052290</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.12" evidence="7"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695569.1">
        <property type="nucleotide sequence ID" value="XM_006695506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDM3"/>
    <dbReference type="STRING" id="759272.G0SDM3"/>
    <dbReference type="GeneID" id="18259267"/>
    <dbReference type="KEGG" id="cthr:CTHT_0052290"/>
    <dbReference type="eggNOG" id="KOG3127">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047993_0_1_1"/>
    <dbReference type="OMA" id="YFMRLAD"/>
    <dbReference type="OrthoDB" id="6710946at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000035">
        <property type="entry name" value="dCMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086:SF18">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="10">
        <location>
            <begin position="211"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS18624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="369" mass="41175" checksum="031A3BDB351B7B34" modified="2011-10-19" version="1">MFIGICGSICAGRRTIARYLVDHHGFTQLYLSGYQHEPGYIITSLDNQPADNQYMFSTPNELMDFVTKRWRERWVTIDIPNEDIFDIYSRRPFFLLVSVDAPLTVRWRRFQNQQHELEQQRVLNEAFLSSTSRDSSTPSGSPSLSPKQKVITTLEEFAHLSDSHLYSPTGNLATLISNATIRLVNTSSSLAHLYATLGKLDLPNPDRLRPSWDSYFMSLASLAAQRSNCMKRRVGCVVVRDKRVISTGYNGTPRGLKNCAEGGCGRCNSGEGSGHALSTCLCIHAEENALLEAGRERLREGAVLYCDTCPCLTCSIKIAQMGISEVVYSKGYSMDGETAAVFREAGVKLRQFVPPANGLIHLEKPELYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDS3</accession>
    <name>G0SDS3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0052800</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695619.1">
        <property type="nucleotide sequence ID" value="XM_006695556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDS3"/>
    <dbReference type="GeneID" id="18259318"/>
    <dbReference type="KEGG" id="cthr:CTHT_0052800"/>
    <dbReference type="eggNOG" id="ENOG502SESG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102601_1_0_1"/>
    <dbReference type="OrthoDB" id="5275361at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990879">
        <property type="term" value="C:CST complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016233">
        <property type="term" value="P:telomere capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024222">
        <property type="entry name" value="Ten1_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12658">
        <property type="entry name" value="Ten1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS18674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="159" mass="17942" checksum="EEEB77353CD1A822" modified="2011-10-19" version="1">MHSVQKVSIQPDLRGAQLVLLPHLRKRSVGEKVRFLGCVMGYDPTTATLTLEHDVHPVTSKAGSPMKTIARVDAHLVLDCLYWDKVRVGEWLNVLGYVEKHKIEGGKFGQEYLPVKEQPQYQPALFVVNIQATYIWSTGPMDIDRYVQTVRVLEAELSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>G0SE09</accession>
    <name>G0SE09_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0062010</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696517.1">
        <property type="nucleotide sequence ID" value="XM_006696454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SE09"/>
    <dbReference type="GeneID" id="18260239"/>
    <dbReference type="KEGG" id="cthr:CTHT_0062010"/>
    <dbReference type="HOGENOM" id="CLU_2426822_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="91" mass="10015" checksum="C4326BFA213AA303" modified="2011-10-19" version="1">MACRYDPTRKVVPVSLARSHQRKAPKRGGKLGFGPRWGGGEREEDEMLQDDRKSPPVALSLSPYHGHGLQETNPSAPLAYEICSAAENELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEF1</accession>
    <name>G0SEF1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="3">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Nuclear thiol peroxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CTHT_0063520</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peroxiredoxin family. BCP/PrxQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="3"/>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696659.1">
        <property type="nucleotide sequence ID" value="XM_006696596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEF1"/>
    <dbReference type="STRING" id="759272.G0SEF1"/>
    <dbReference type="GeneID" id="18260390"/>
    <dbReference type="KEGG" id="cthr:CTHT_0063520"/>
    <dbReference type="eggNOG" id="KOG0855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_2_0_1"/>
    <dbReference type="OrthoDB" id="338622at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03017">
        <property type="entry name" value="PRX_BCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000157">
        <property type="entry name" value="DOT5p Nuclear thiol peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050924">
        <property type="entry name" value="Peroxiredoxin_BCP/PrxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801:SF23">
        <property type="entry name" value="PEROXIREDOXIN DOT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="15">
        <location>
            <begin position="52"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="219"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="231"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGS18328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="287" mass="30865" checksum="5158F816F6EA7161" modified="2011-10-19" version="1">MPVTTRSKRKADDAPAAEPAALPSTKRSRKPKAEKDGAEADKKEEVQKEKAATNGAATGEETAVPSVGDVINLDGFGGEIELNDGAKTTLKELVDKSKSGVVIFTYPKASTPGCTRQACLFRDNHSSLTSTSGFSIYGLSADSPKANTTFQTKQKLPYPLLCDTKTTLLTALGLKKPGGKGAARGVFVVDKTGKVLALELGSPEGTVKVVQGIVEKLGGGESKEEDVEDSKEEKKEEKKEDSKEEKKEDSKEEKKDGEEEKKEEKKEEEAKTNGEKKEGGEEKKEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEK5</accession>
    <name>G0SEK5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Geranylgeranyl pyrophosphate synthase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0064070</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696713.1">
        <property type="nucleotide sequence ID" value="XM_006696650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEK5"/>
    <dbReference type="SMR" id="G0SEK5"/>
    <dbReference type="STRING" id="759272.G0SEK5"/>
    <dbReference type="GeneID" id="18260445"/>
    <dbReference type="KEGG" id="cthr:CTHT_0064070"/>
    <dbReference type="eggNOG" id="KOG0777">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014015_10_0_1"/>
    <dbReference type="OMA" id="DLYWTHN"/>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF72">
        <property type="entry name" value="THIJ_PFPI FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G01210)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="316"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="333"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS18382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="648" mass="73983" checksum="2FE6ED8F239B5632" modified="2011-10-19" version="1">MEYRYSDPVNFDPSSPWVCDLIGKLPVRAHRDNELADRGCLRAQRDWKQLFGDFPPGFTGGGMGLKFNSVALCVPEALPDRIEHVAYFFELFNLVDDAIDHAESPVQVIAPFAADAWRTLECIKSNKDLVRNGQEHGLTFEEILCNFVRAVIDLDPDGAEMILREIENWMLALMKDKTRSEAPDLDEYLDSRIIDGGLLPLWLHMVLVNDLFSWEKEYGGTQKSGATQGPMNAIRVLMEKHGMTLDQAKSTCIERAKELRDEYLKIAEDKNSRPDISKDGLRLLDNLRLFAGGHVFWSAECPRFRPEQEQDWKLKTMERNQTRDTTDPLTSDEMAKPIDTRQTVVEDKRRADAPSDYLDSLPSKGIRDTAIDSLNFWFEIPIEQVTRVKKIVNLLHGASLLMDDIQDSSVLRRGQPAVHLVFGQGLAINAAGYRFLEALREVRRLENEKCLDVFCDELHDLYVGQSNDLSWTRMMKCPSEAEYLAMVDGTGLFRMLARMLDALSNSPRKPDVKVLIRFMSLLGRLFQIRDDYMNLTSSDYTKQKGFCEDLDEGKFSLPLIHALGRCREKPDGTMRTNLICNLLSQRHSDGRLSKEQKNLILEQMRAGGSLEYTRRALHALQMELKILGKRMGLFENRQLGALLDKLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEZ7</accession>
    <name>G0SEZ7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0060260</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696344.1">
        <property type="nucleotide sequence ID" value="XM_006696281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEZ7"/>
    <dbReference type="STRING" id="759272.G0SEZ7"/>
    <dbReference type="GeneID" id="18260064"/>
    <dbReference type="KEGG" id="cthr:CTHT_0060260"/>
    <dbReference type="eggNOG" id="KOG0226">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_29_0_1"/>
    <dbReference type="OMA" id="FTAFQPR"/>
    <dbReference type="OrthoDB" id="1749473at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12383">
        <property type="entry name" value="RRM_RBM42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034215">
        <property type="entry name" value="RBM42_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF11">
        <property type="entry name" value="RNA-BINDING PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="251"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="3">
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    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="183"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="388"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS18013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
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    </evidence>
    <sequence length="397" mass="40959" checksum="04BC41CB5A82DF54" modified="2011-10-19" version="1">MSYPGPPGVSKPSHPSLPPRPPVVKLPGFKPAFSPAPAATASPAPPVPPTVSAPGYTAPAPSYPGYPPVAAPPSYGVPPTATPYAGPAAVPPAAGRGAGYGPVAPTTTPFNYPATTPYTQAPSYYGASAATTNGYGAHAMRNAYHHHNNPGADSADYDPELAAQIAQWQSAYMPKDPDDPNNKAGAGATGAQKGAAGAQASSGPQIPDPALAAQAAAAGTEPGGKKKTVVREGGGKKWTDDTLLEWDPSHFRLFVGNLAGETTDESLLKAFSRWKSVQKAKVIRDKRTNKSKGFGFVSFSDPDDFFQAAKEMNGKYIQSHPVVVKKAKTEIKPVVMKDDKKGNKKDKKGGAEQHASGSGMGGAHHEATAYHPHLGPIKPAGVTKPGQKTKGGLKLLG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-04-13" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFB5</accession>
    <name>YTM1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome biogenesis protein YTM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">YTM1</name>
        <name evidence="6" type="ORF">CTHT_0061460</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2015" name="Nucleic Acids Res." volume="43" first="11017" last="11030">
            <title>The structure of Erb1-Ytm1 complex reveals the functional importance of a high-affinity binding between two beta-propellers during the assembly of large ribosomal subunits in eukaryotes.</title>
            <authorList>
                <person name="Wegrecki M."/>
                <person name="Rodriguez-Galan O."/>
                <person name="de la Cruz J."/>
                <person name="Bravo J."/>
            </authorList>
            <dbReference type="PubMed" id="26476442"/>
            <dbReference type="DOI" id="10.1093/nar/gkv1043"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) IN COMPLEX WITH ERB1</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2016" name="Nucleic Acids Res." volume="44" first="926" last="939">
            <title>Concerted removal of the Erb1-Ytm1 complex in ribosome biogenesis relies on an elaborate interface.</title>
            <authorList>
                <person name="Thoms M."/>
                <person name="Ahmed Y.L."/>
                <person name="Maddi K."/>
                <person name="Hurt E."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="26657628"/>
            <dbReference type="DOI" id="10.1093/nar/gkv1365"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.67 ANGSTROMS) IN COMPLEX WITH ERB1</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 2 3 4">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. The complex is held together by ERB1, which interacts with NOP7 via its N-terminal domain and with YTM1 via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The NOP7 complex associates with the 66S pre-ribosome (PubMed:26476442, PubMed:26657628). Interacts (via UBL domain) with MDN1 (via VWFA/MIDAS domain).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat WDR12/YTM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696462.1">
        <property type="nucleotide sequence ID" value="XM_006696399.1"/>
    </dbReference>
    <dbReference type="PDB" id="5CXB">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.10 A"/>
        <property type="chains" value="A=1-495"/>
    </dbReference>
    <dbReference type="PDB" id="5CXC">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="A=1-495"/>
    </dbReference>
    <dbReference type="PDB" id="5CYK">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="A=1-495"/>
    </dbReference>
    <dbReference type="PDB" id="5EM2">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.67 A"/>
        <property type="chains" value="B/D=1-495"/>
    </dbReference>
    <dbReference type="PDB" id="6QTB">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.89 A"/>
        <property type="chains" value="B/E=8-98"/>
    </dbReference>
    <dbReference type="PDB" id="8I9X">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="CD=1-495"/>
    </dbReference>
    <dbReference type="PDB" id="8I9Y">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="CD=1-495"/>
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        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
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    <dbReference type="PDB" id="8PV2">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.63 A"/>
        <property type="chains" value="CD=1-495"/>
    </dbReference>
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    <dbReference type="EMDB" id="EMD-35287"/>
    <dbReference type="EMDB" id="EMD-35288"/>
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    <dbReference type="KEGG" id="cthr:CTHT_0061460"/>
    <dbReference type="eggNOG" id="KOG0313">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_0_1"/>
    <dbReference type="OMA" id="DHKYVEF"/>
    <dbReference type="OrthoDB" id="10251381at2759"/>
    <dbReference type="EvolutionaryTrace" id="G0SFB5"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="Ribosome biogenesis protein ytm1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WDR12"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WD40_PAC1"/>
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        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
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        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028599">
        <property type="entry name" value="WDR12/Ytm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF11">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0853">WD repeat</keyword>
    <feature type="chain" id="PRO_0000435844" description="Ribosome biogenesis protein YTM1">
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            <begin position="1"/>
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        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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        <location>
            <begin position="342"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="strand" evidence="8">
        <location>
            <begin position="357"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="strand" evidence="8">
        <location>
            <begin position="367"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="strand" evidence="8">
        <location>
            <begin position="372"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="strand" evidence="8">
        <location>
            <begin position="382"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="strand" evidence="8">
        <location>
            <begin position="391"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="strand" evidence="8">
        <location>
            <begin position="401"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="strand" evidence="8">
        <location>
            <begin position="413"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="helix" evidence="8">
        <location>
            <begin position="426"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="strand" evidence="8">
        <location>
            <begin position="432"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="strand" evidence="8">
        <location>
            <begin position="437"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="helix" evidence="8">
        <location>
            <begin position="444"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="turn" evidence="8">
        <location>
            <begin position="448"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="helix" evidence="8">
        <location>
            <begin position="456"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="turn" evidence="8">
        <location>
            <begin position="459"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="strand" evidence="8">
        <location>
            <begin position="463"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="strand" evidence="8">
        <location>
            <begin position="472"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="strand" evidence="8">
        <location>
            <begin position="480"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q12024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="26476442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="26657628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5">
        <source>
            <dbReference type="PubMed" id="26476442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="EMBL" id="EGS18131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="5CXB"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="5CYK"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="5EM2"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="6QTB"/>
        </source>
    </evidence>
    <sequence length="495" mass="52939" checksum="88115FB91CB1B37F" modified="2011-10-19" version="1">MDAPMEDAPAPVAQVKVIFTTTEPDLELPESKRQLLVPADIRRYGLSRILNSESMLDTGSIPFDFLINGSFLRSSLEDYLTSNGLSLETTLTLQYVRSLIPPVYEASFEHDDWVSAVDVLSATSPAGRWSSAANSSAAVQPGQERVLSASYDGLLRIWNASGSVIATSPSGSHGGHTASIKAAKFLTSDRLASAGMDRTVRVWKYTESDHFTGELKPTLELYGHTGSVDWLDVDGHSKHILTASADGAIGFWSASKASAPEPDASLLPGAHVSKRRKATSSVSTAQRGPLGLWSIHTAPATAAIFDPRDRTVAYSASQDHTVRTLDLTTGQVVSTLTLTHPLLSLSALTRAGTTSPLLAAGTSARHITMVDPRASSATTSVMTLRGHANKVVSLSPSPENEYSLVSGSHDGTCRVWDLRSVRPATKEEGSLGGVSEPVYVIERESWASKGKKKRPVAGDGCKVFSVVWDKLGIFSGGEDKKVQVNRGRNIVTEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFB8</accession>
    <name>G0SFB8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L-serine ammonia-lyase</fullName>
            <ecNumber evidence="5">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0061490</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="5"/>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696465.1">
        <property type="nucleotide sequence ID" value="XM_006696402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFB8"/>
    <dbReference type="STRING" id="759272.G0SFB8"/>
    <dbReference type="GeneID" id="18260187"/>
    <dbReference type="KEGG" id="cthr:CTHT_0061490"/>
    <dbReference type="eggNOG" id="KOG1250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021152_3_1_1"/>
    <dbReference type="OMA" id="AEQGCEH"/>
    <dbReference type="OrthoDB" id="7773036at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000040">
        <property type="entry name" value="L-serine dehydratase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF2">
        <property type="entry name" value="CATABOLIC L-SERINE_THREONINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="11">
        <location>
            <begin position="19"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS18134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="314" mass="33049" checksum="390A3E30E0B9C88A" modified="2011-10-19" version="1">MMYLAIPSTNDPSSPPSVHFYCSSGGNAGLACATTAAALNCPATIVVPDSTSAFMISKLRSLGAEVIQTGASWAEADAYLRETFLSSPAANGVNGHSSSDEISKAAPKKNVYVPPFDHPDIWTGVSTLVDELLTSMPQISRTGVIDGIVCNVGGGGLLNGIMEGLERHDMLSTTKVLAVETEGADSLHASVLAGEHVTLPRITSIATSLGARRVSEKTWEWAVKEGGQSLISAVVTDAEAAEACLRFLDDARLMVEVSCGATIATVYKGGFLRRHLGKGLTDEEWATKNVVVVVCGGSNVSWEILEKYKKTFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFQ2</accession>
    <name>G0SFQ2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LDB19 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0071700</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697435.1">
        <property type="nucleotide sequence ID" value="XM_006697372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFQ2"/>
    <dbReference type="STRING" id="759272.G0SFQ2"/>
    <dbReference type="GeneID" id="18261208"/>
    <dbReference type="KEGG" id="cthr:CTHT_0071700"/>
    <dbReference type="eggNOG" id="ENOG502QS9U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026015_1_0_1"/>
    <dbReference type="OMA" id="MVVAEEW"/>
    <dbReference type="OrthoDB" id="3832628at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024391">
        <property type="entry name" value="LDB19_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13002">
        <property type="entry name" value="LDB19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LDB19 N-terminal" evidence="2">
        <location>
            <begin position="181"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="532" mass="59109" checksum="D82EA6D56DC0478D" modified="2011-10-19" version="1">MPHRVADFFRSSISSPSLDSQIPHPTQKSASSQPFKSSRSRRSRKPLERLTSTLLFFEGGSGGGDDDSENATPDDTRAPPAAPSLKMADSRASSLSSESHKDHGHHHHYRISLSSMHFGRSHKESHVSMPAMLTWELESPPAVMYGEPETSSGALVSGQLYLDVKEDFLEVYLFFATLNLHVVQKKPFGSHCSECANQYTEIKRWDLLPHPLVLTKGIHTFPVSVLLEGHLPASMDTPLVSIAYEFKAEVHSRSKGSSLPPIKLEKVWDVKRSLATSETPHHSVRVFPPTNIKASAHYPHVVHPIGSNTLSLRLDGIAKHNSKVNTIEYWKLKKLTWKLEETIKTVAPACGRHSPRATDSSDDGHNNKKGVVRAETRVIGEKTLFSGWKSNYTSATDSLVELELDYSLTKGAKYACDTRSRDGTEVTHQLMIEMVVSQEWAPVNRPSLVTHTGVGRILRMHFGTILTERAGIGISWDNEAPPIYQDVPPSPPAYCEATQRQQHSTEQCRQQSFSGNPPWSEVKSLFHVDPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFQ9</accession>
    <name>G0SFQ9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0071770</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697442.1">
        <property type="nucleotide sequence ID" value="XM_006697379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFQ9"/>
    <dbReference type="STRING" id="759272.G0SFQ9"/>
    <dbReference type="GeneID" id="18261215"/>
    <dbReference type="KEGG" id="cthr:CTHT_0071770"/>
    <dbReference type="eggNOG" id="KOG1968">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003721_0_0_1"/>
    <dbReference type="OMA" id="RNHLVQQ"/>
    <dbReference type="OrthoDB" id="9996895at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF21">
        <property type="entry name" value="ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="661"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="584"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="622"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="711"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="758"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1243"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1275" mass="141800" checksum="7701D2EFBC7203A9" modified="2011-10-19" version="1">MTNNAPSQDCINGRPIHPFFTLSRHHPSGIKRAPDNASIQNCDASLPSDAATGSDKTNNNTEQCAQSVNGRGQRRKADRDAGNDETQKKAPPRKRTRHSAGSNITAHLVKLPKGSDSSGTREQDDGDDQALEDLAQKGQATNTLEKPTCSGTSLAQQDGQAARDDTVVQIDPGQLDSSACDTNDKQTSRCHSTGDKTPELDLWKVPKVPNENMEKPKIPRLNTKTGMLGSPPKLKEIQAGEEDADAQRSVVLMHDRKPPIMIVRIPYGISPDSRVRIGEAINSILDGRKIYPDFKSKQSASVNKDNAAEVSGFSSSKPAKAVHPFFLGRTKKPAPVQQQQDSDPSTSTSSFTNIQAQHYSSIPCSSKRSRPIPTIKHHMPQFGVNSMGIKFPGAKPPSWPWKGMMHIRGEEHETVRTIDITRLHAPRKSKGNIVRILPGESVVDIMSQSINIAAITKAVRNIDTDNFPPPPPELRLPNKHFESGSKLQARILPELKTFKACPVQSVQQSLPRMCNGLNVRPPPQLARLFHSISLELSAFDMSQCESRDWVQKYAPANAVEILQPGREAFLLRDWLQALMVQSVDTGSPDADKGKTGSKTKGTANKKKRKKKLDGFIVSSDEEDQDFYEPSDEDTDWTPSGHRGIVRPTVVKPLSNRNRGKTPNTLVISGPHGCGKTAVVYAVAKELGFEVFEINSSSRRSGKDVLEKIGDMTRNHHVQQHQVTSKPDDESPVPQNNVEEDIKSGKQSTMNAFFKPKLKGSVARQEKPSTQNVKFEPPKKEPTKNQRQSLILLEEVDILYEEDKQFWATVIGLIVQSKRPFVMTCNDETLVPLQSLRLYGIFRFSIPPRDLAVDRLLLIAANEGHALTRRAVEQLYDSRGCDLRAATMDLQYWCQVGVGDRRGGFDWFVPRWPKGVDLDENNEIIRVVSEGTYQYGMNLLCRDRIADSKLSPQLVEEELLHQTSESWTFDLGHWQDSVGLDDWAMDMASHMENARDRQHILEASFAVFMEEAIDTTQPEPSAKAQDDWILGVTHLDTPFITHYNSLAIPISSAMKSLARSYLHQRTVTMQRDTTRLLPLSEEQAIRCLQKSFTTPPLNAPVINRMDFAFAFDPIAASDSTQPTSYLEPSVFDRNMELITLDVAPYVRSIVAYDVRLQRQRLKHSNLVSEGGRAGPKRMRTTRTALSALEGGSRSTVRGEKWFKADINPYLVAKTAGAGWNGFDKEDLATSEEQVKSSFQNSTYNISSVTTPSKEEMVAGRPKRQKVVAVETDDDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFU7</accession>
    <name>G0SFU7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sorting nexin MVP1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Sorting nexin mvp1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0072190</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for vacuolar protein sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697480.1">
        <property type="nucleotide sequence ID" value="XM_006697417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFU7"/>
    <dbReference type="STRING" id="759272.G0SFU7"/>
    <dbReference type="GeneID" id="18261257"/>
    <dbReference type="KEGG" id="cthr:CTHT_0072190"/>
    <dbReference type="eggNOG" id="KOG2273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009058_1_0_1"/>
    <dbReference type="OMA" id="SSPWDMP"/>
    <dbReference type="OrthoDB" id="10064318at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07597">
        <property type="entry name" value="BAR_SNX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06866">
        <property type="entry name" value="PX_SNX8_Mvp1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000037">
        <property type="entry name" value="Sorting nexin mvp-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000072">
        <property type="entry name" value="Sorting nexin MVP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028662">
        <property type="entry name" value="SNX8/Mvp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035704">
        <property type="entry name" value="SNX8/Mvp1_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045734">
        <property type="entry name" value="Snx8_BAR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47554">
        <property type="entry name" value="SORTING NEXIN MVP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47554:SF1">
        <property type="entry name" value="SORTING NEXIN MVP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19566">
        <property type="entry name" value="Snx8_BAR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="12">
        <location>
            <begin position="344"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="156"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="184"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="241"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS17862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="723" mass="79990" checksum="F185D3D1B73264C7" modified="2011-10-19" version="1">MSLFGSSPTGESSGLRSSAFGRSSLFDDEPPMTRSTTTALFADDDPNDSPWDIPAPKKPQTRAELIRNLLPPSLIPDSYIEAFDKIFSEDGKAGKITAAGVTRTLAAAKLGADAQAKIMSIVGPENESEELALDRNQFNVLLALIGLAQEGEPISLDGVDERRRNLPQPDLHGLITKSTAAPSLPELTPTSPERPTSSSAALNPPSPKQQRATVRKPPMEYPEDPWNTPDLHKNHNHGPEPSTTNGSHARTSSAVSNGDSLFSTSPQDTSRRSTSAFTTGNIQTSAPPSVVDSTNAWGSLDGVPAGLGGFGDPAHQNPFGTGPLGSTTAPNRTIGGGRTVSPVEETVTVTLMPEKEGIFLFQHHNYEITCAKRGSKVIRRYSDFVWLLECLHKRYPFRVLPLLPPKRIAVNGNHFSNDGAFIEKRRRGLARFLNALVRHPVLSQEQLVVMFLTVPTELSVWRKQATITIQDEFAGRPMPPGLEESLPPTLEELFSRTRAGVQRSAELYINICNIMDRLVKRTEGVAADHARLALSLISLTEASKDTYATDASDVPMLNDGLQTMSRHLRNAQTLMEDEARAWEEGVLEDLKRQRDALVSLRDLFDRREKLDKDNIPQLERRIAANEAKLAALRSKPEGMVKPGEIEKIVEMIIKDKESIVNQHNRSVFIKECIRDELIYFQHTQYNVSRWNQDWAQERVKYAEMLADNWRRLMDGLEGMPLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGV5</accession>
    <name>G0SGV5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">rRNA biogenesis protein RRP36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0067710</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Associates with 90S and pre-40S pre-ribosomal particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the RRP36 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697062.1">
        <property type="nucleotide sequence ID" value="XM_006696999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGV5"/>
    <dbReference type="STRING" id="759272.G0SGV5"/>
    <dbReference type="GeneID" id="18260809"/>
    <dbReference type="KEGG" id="cthr:CTHT_0067710"/>
    <dbReference type="eggNOG" id="KOG3190">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048802_0_0_1"/>
    <dbReference type="OMA" id="ERKEMPW"/>
    <dbReference type="OrthoDB" id="448446at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009292">
        <property type="entry name" value="RRP36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06102">
        <property type="entry name" value="RRP36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 10" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="218"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS17444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="332" mass="37860" checksum="0263D42E8B5732CA" modified="2011-10-19" version="1">MSAVKRKIPASLLERRVRPRYEPEPDSDDLQEYDDSSSEAPSEEGVRSDESGSESDSGSESEESEMSGSEDEGSDDSSDSEASKSEDEASKLDISRFTFGALAKAQEALSKQTEDSGDSSSESDSDDGRKKKDGKDKKSDQKIPKRSNKHAPVEMSAKKPVSRKRDFLTVTAELKKPKPRDPRFLPIPGTRGSGNPTIEEIKARKRYAFLDEYRESEMQQLREAIAKTKDAAAKEKLQRALMSMESKKKAQERKDKEREILAEHKKREKELIKKGKKPFYLKRSEQKKRLLVEQYQGMKKKQVDKAIQRRMKKIAAKERKLLPTERRGREDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGY6</accession>
    <name>G0SGY6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CTHT_0068020</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 22">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HRD1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697093.1">
        <property type="nucleotide sequence ID" value="XM_006697030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGY6"/>
    <dbReference type="STRING" id="759272.G0SGY6"/>
    <dbReference type="GeneID" id="18260840"/>
    <dbReference type="KEGG" id="cthr:CTHT_0068020"/>
    <dbReference type="eggNOG" id="KOG0802">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009169_1_1_1"/>
    <dbReference type="OMA" id="HILHFAC"/>
    <dbReference type="OrthoDB" id="7759664at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16479">
        <property type="entry name" value="RING-H2_synoviolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057992">
        <property type="entry name" value="TPR_SYVN1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058051">
        <property type="entry name" value="Znf_RING_synoviolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF184">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SYNOVIOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25563">
        <property type="entry name" value="TPR_SYVN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="19">
        <location>
            <begin position="342"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="420"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="586"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="712"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="420"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="586"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="712"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="766"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="796"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="858"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGS17475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="869" mass="96559" checksum="8EFA3BEF7F5B45F0" modified="2011-10-19" version="1">MRLAWYAGASTALAAAVVTSAFYQRSNFYSAMVHLSQSNFSLMVLINLVLVVYTTFMYLLQRICFGPLRATEIEQLYEKAWFAVTETCLAMTVFRDEVGAFFLVMFTALVTGKVWGWIGEGRVEVLEQQPPANPRLFHTRLVISLFISIAYDIWLLTYTVRAVIQQARPTMMVMFLFEFAVLTISSLHTASRYIFSLVEQQAIKRQTRQRLEERRRRIREQRAEILRRRDAEGASTADNEPLPDENDIDEMDIEVPGWENKGQWVLILDLLADLIKLGIYTAFFLVLLRFYGLPIHIIRDWFMTTRSFLKRLHAVIRYRQALKHMDQYPDATAEELEREDTCIICREEMRPWDPNDSTLVQRSRAKKLPCGHVLHFGCLKSWLERQQVCPTCRRPVTQQRQQPAVVNGNAMVFRLGLNLPAGQNQPAQPPANNGGQVPGGDRPAQAPGAPDPRANNQNRNIRMFNLGPIRVGFAQGGVEELGEMAQRLQMIPNAPNPPVPTPMVPAPQATAPNTGSLIPALDDLRTQLLTLGQQVRQELANLNNAAQELQYLNALMNEITRLRQQQQQQQQQQQQQQQQQQQQQQQQQQQQSRSHQQSTQNTTTNSPNPVLHIPQPQQVFTYPFTQLHASYPLGPRQASAVVTRHVSTAQVAPIPSGSPDLPEGVVIPPGWTLLPLQRMDMAHPTSDGPQNAGQASVLNQQEIMQLLIPQAPNNSQSQGTSPARAENGPSGQAVEQRTTENPPPEPSRTSESSGTAVDSGEQRQLSASPSVAAPTPVAPIWGGSAQLFGGRFTVPSGAQGTLTPSSQTNQGESNDGGQLSSTTANGATSDSNVQPQSRPEVNGTAGEGQRGPRAVTVEDVDDEGEEDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0SH00</accession>
    <name>G0SH00_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0068170</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697107.1">
        <property type="nucleotide sequence ID" value="XM_006697044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SH00"/>
    <dbReference type="STRING" id="759272.G0SH00"/>
    <dbReference type="GeneID" id="18260855"/>
    <dbReference type="KEGG" id="cthr:CTHT_0068170"/>
    <dbReference type="eggNOG" id="ENOG502RJPA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056754_0_0_1"/>
    <dbReference type="OMA" id="PHSWREP"/>
    <dbReference type="OrthoDB" id="3439027at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="272" mass="29485" checksum="560AA7F4684607C5" modified="2011-10-19" version="1">MRDPKEPSGSCIPHGSGPWSPVQVYLEVSGSSNDEAITNNSDLAHMGGDPLVYFLTPEPPSYGIEESGISDLGDMDFLMEFDAGIEDAAHPRPVVRSVSPSNLEGFSRPPGLTTPPKSPTMPDLDYDTTATPDEHDLLSTPPSSFSRRLQGPVLGQTQGDRPDDGRSWEGSQMLTPPSSTLLDGIPCIGLSSTASTSNRGRALRRNLHPRRRSPHAWREPSPDVWAIEEETEEELVSDSQMAIITGQKMSEEVAGIDVGQIGKPKPTMKERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>G0SH30</accession>
    <name>G0SH30_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0068490</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697137.1">
        <property type="nucleotide sequence ID" value="XM_006697074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SH30"/>
    <dbReference type="GeneID" id="18260887"/>
    <dbReference type="KEGG" id="cthr:CTHT_0068490"/>
    <dbReference type="HOGENOM" id="CLU_986962_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="282" mass="32056" checksum="CEC83D3D4036B9B6" modified="2011-10-19" version="1">MFSRFTGQYQSQFQEYRHPLSVRILVSGGRKWVLAIWRKTKAKAKGKGKQNGSSGANNGSSDQRLKNGWKTDDCVIRNEAKASLSNDGRSTLGQERGGIWSRNVVEDAMDWPQTSATTGALGRWWEDIEVGSSKGGYHHKCRSVRSFVLEEGSLEDIWFKHRHHNNGRTWMVSSINSDYRQKSAARLIPWVYGFLAAKIMTMRWKAGGGYVVVNGALKEERSQKGKDRWLELLFISLWSISGLYYPVSDPSVIDQGSDRKLVKPTGQRNPDEWDEEVELQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHB1</accession>
    <name>G0SHB1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 subunit A</fullName>
            <shortName evidence="7">eIF3a</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 110 kDa subunit homolog</fullName>
            <shortName evidence="7">eIF3 p110</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Translation initiation factor eIF3, p110 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TIF32</name>
        <name evidence="10" type="ORF">CTHT_0069380</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the eIF-3 subunit A family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697218.1">
        <property type="nucleotide sequence ID" value="XM_006697155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHB1"/>
    <dbReference type="DIP" id="DIP-60990N"/>
    <dbReference type="IntAct" id="G0SHB1">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0SHB1"/>
    <dbReference type="GeneID" id="18260976"/>
    <dbReference type="KEGG" id="cthr:CTHT_0069380"/>
    <dbReference type="eggNOG" id="KOG2072">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002096_2_1_1"/>
    <dbReference type="OMA" id="EHITNKR"/>
    <dbReference type="OrthoDB" id="18884at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043614">
        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.860:FF:000003">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.860">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.10">
        <property type="entry name" value="UVR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03000">
        <property type="entry name" value="eIF3a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027512">
        <property type="entry name" value="EIF3A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054711">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3, THETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22591">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="335"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="802"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="607"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="802"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="942"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="958"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="996"/>
            <end position="1008"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS17600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1086" mass="123147" checksum="6F1FE1E5BA902369" modified="2011-10-19" version="1">MPPPPHQKPENVLKRAQELIGVNQAPAALSLLHEHVTSKRSRNVPITSLEPVMLLLVELAVEQKKGKLAKDALYQYKNIAQNTNVATIELVLKKFIELASEKVKAAQQKAEEVQSSIESAAVEDLEASETPESILLATVSGEQSKDRTDRAIVTPWLKFLWEAYRTVLDILRNNARLEILYQSTAMQAFDFCLKYTRKTEFRRLCELLRNHVQTAAKYSAQMHAINLSDPDTLQRHLETRFQQLNVAVDLELWQEAFRSVEDIHTLLTLSKRPPKNIMMANYYEKLTRIFLVGENYLFHAAAWLRYYNLLRHSAALLATGQSKKADNPPATEADLQKAATFVVLSALSIPVISTSRSRGAMVDFDEARKTKNSRLTHLLGMTQAPTRASLFRDVQSKSLLRRAQPQIRELYTILEVDFHPLSICQKISPILKQIGADPEMQKYIAPLQQVILTRLFQQLSQVYETVDLSFVESLAQFPEPFQVSRGMIEKFIMNGNKKGDLSIRMDHATGVLSFDVDVFSSARAAHAGSAAGSAESETGSVQRLQSTPSQIVRSQLTRLAEALFTSCRYIDPSFNEAQIKAREAALARAKAGAEKEHLEVLARKEIIQRRKDQASEAQAQREKENARRKMLQEQALQQAEAARLAEEARIREQKRLQSEREAIKRKEVENMLKDMKLDSVNLEDLENLDSNKIRMIKLQQLEREKNTIAEKLRITGKRLDHLERAYRREEAKKLPEDYAKQRERDLAAYEAMKARTLKEAEQKHKEDLELKHRLSRLMPFYESFRAELHERRREQFEKRRRDAEREFEKAVNQRRKEYRERKLREKREREEKERALREAEERAAREREEERKRQEARREELQRLREEREKERERAREAAARQQQREEEAMARRRAEKEKQAAAAAAGSLPIREPQPISTSGPPRLNLIGGKTPTWREREAAKQAAAAGGAAPPSENNTPPPAARPTPPPMERSSSSDVPSAGPPRLPLAGAAKPGGWRERLAAKEAAAKEAAASGNAPPPGPPPRTGSGRGVPLDRTGSGRGVPLDRVGSGRGGSKDSKEPAPEPLKPSGAPGKWVPRFRRENAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHB7</accession>
    <name>G0SHB7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">O-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0069450</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Sterol O-acyltransferase that catalyzes the formation of stery esters.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697224.1">
        <property type="nucleotide sequence ID" value="XM_006697161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHB7"/>
    <dbReference type="STRING" id="759272.G0SHB7"/>
    <dbReference type="GeneID" id="18260983"/>
    <dbReference type="KEGG" id="cthr:CTHT_0069450"/>
    <dbReference type="eggNOG" id="KOG0380">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018190_3_0_1"/>
    <dbReference type="OMA" id="RCHDYRR"/>
    <dbReference type="OrthoDB" id="10039049at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF7">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000439">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="453"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="483"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000439-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS17606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="537" mass="60921" checksum="6A9C70BDE3CD17AF" modified="2011-10-19" version="1">MTEKQAFEVTGVDRLGNTIIRRRVVEDINRAESENPNGTVNSSASNGQASAAVAIKKAAYKGKYRHVAAIHEEAKPSCLSHDATDTPSFLGFRNLMVIVLVASNLRLIIENIQKYGVLICVRCHDFRASDVKLGLGLYFLIPLHLLLAYFIELVAASHARSTRAKIEKEKRDGSSSPTALQSKRFQRTWTVIWLLHSLNATVALVFTSWVVYNYIHHPLIGTLTETHAIITWLKTASYAFTNRDLRHAYLHPAKGELDALPELYRQCPYPKNVTIKNLVYFWWAPTLVYQPVYPRSEKIRWVFLFKRLGEVVVLSAFIWFLSAQYATPVLVNSLDKIASLDYFSILERLLKLSTISLVIWLAGFFALFQSGLNALAEITRFGDRSFYEPWWNSPGLGVYWRTWNKPVHHFFLRHVYQPMRGRGWSHKAASLVVFFLSALLHELLVGIPTHNLIGIAFLGMFLQIPLVQITAPLERMKSPSGKLLGNTIFWVSFTILGQPLAVLLYFYAWQAKYGSVSRSMTTMQRPPVCPPCPSSCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHI4</accession>
    <name>G0SHI4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative calcium ion binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0070130</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697291.1">
        <property type="nucleotide sequence ID" value="XM_006697228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHI4"/>
    <dbReference type="STRING" id="759272.G0SHI4"/>
    <dbReference type="GeneID" id="18261051"/>
    <dbReference type="KEGG" id="cthr:CTHT_0070130"/>
    <dbReference type="eggNOG" id="KOG0031">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_906145_0_0_1"/>
    <dbReference type="OMA" id="PIATNYP"/>
    <dbReference type="OrthoDB" id="429467at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050403">
        <property type="entry name" value="Myosin_RLC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23049">
        <property type="entry name" value="MYOSIN REGULATORY LIGHT CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="133"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="203"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="56"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS17673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="307" mass="32307" checksum="A8BAC91712E3E738" modified="2011-10-19" version="1">MVYQPLTTHEITERADGFQTIPIVIFDTKIITISPAPIASIHGPIATNYPGIIVTGEDGRVEDAPDSEPPTPPRHGTTPQPAPAPAHAQSPMPVPGPARSPAARSPVPTASGIGIPTATNIGQANALSQLQPSQVRTMREAFQILDRDSDGAVNREDIADMLNQLGLPSTPVDVAQFFPPSGPQTMTMAMFLNSIATPLAAMSPPSELISALEAFDDDDSGQIDVEELRDALLHTAPEPGQRPLTAADVDKVISGFTGRRAFSKSSSKAGSLGQAKRGDVFRYQDFVNMLIGKNAGGEQASEMAEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHK2</accession>
    <name>G0SHK2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Condensin complex subunit 3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0070310</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CND3 (condensin subunit 3) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697309.1">
        <property type="nucleotide sequence ID" value="XM_006697246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHK2"/>
    <dbReference type="SASBDB" id="G0SHK2"/>
    <dbReference type="STRING" id="759272.G0SHK2"/>
    <dbReference type="GeneID" id="18261069"/>
    <dbReference type="KEGG" id="cthr:CTHT_0070310"/>
    <dbReference type="eggNOG" id="KOG2025">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004446_0_1_1"/>
    <dbReference type="OMA" id="FRATQIT"/>
    <dbReference type="OrthoDB" id="27187at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027165">
        <property type="entry name" value="CND3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025977">
        <property type="entry name" value="Cnd3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418:SF5">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12719">
        <property type="entry name" value="Cnd3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear condensin complex subunit 3 C-terminal" evidence="9">
        <location>
            <begin position="641"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="569"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="986"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="228"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="570"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="986"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1055"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1093"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1125"/>
            <end position="1137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS17691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1148" mass="126252" checksum="4319DB34936C9AC1" modified="2011-10-19" version="1">MPPRTRSTRSSRSSSAIDIPEETPDNALRTQVTTVFREAQRTTASHRKLVVTLRKIQEACCYEPATGQKQSGAAAALSEFDEDDFNTEFVRCALRILPVKKSEGVGEKTVRFVSLFLRHAIEKDNELLGDTQMDEDDADNSTMPETPSTRLTSHLMETILPMLMAKDKFVRYRAAQLLAHIVNSLDAIDDDLYQKLRAGLLRRIHDKEPMVRAQAVLGLGRLAGNALDEEPGAGDSDLDGDDDGPGGASGVSLMDKLMDVMKNDPSADVRRTLLVNLPITPKTLPSLLERARDQDPATRRAVYSRLLPALGDFRHLSLSMREKLLRWGLRDRDENVRKAAARLFRERWIEDCAGTPRPEPGQPIELSPPNMDALLELLERIDVVNSGGENGIALEAMRGFWEGRPDYRDAMVFDDHFFETLSAESVFALRTFNDFCRNEAGGKYEALIEEKLPEVTKLAFYLERYIKVLIDAIKRAEEQGEEEEEDTAEQEFIVEQLLHIALTLDYADEVGRRKMFALLRQTLSIPELPEECTKLTVMVLRDLCAPDAAGEKEFTSVVLEAVADVHDTIVDEDDDDANVPAEDDESFVSARSEVSRESTPAPGGGEGGGSNSRKRGRSPTPKMTEEEAAAKAIREIMINMKCLHIVQCMLQNVQGQLQSNDNLISMLNNLVVPAVRSHEAPVRERGLVCLGLCALLDRSLAEENLTLFIHFFAKGHTALQITALHILTDILVVHGAQLLSANPTLLKVYVKALRSGAKHPELQAVAVVAASKLLLGRVVSDRDVAAELLKTLVVAYFEPASAGNQSVRQALNYFLPVFCYSRAENQDLMRRVALDALHTLYNVREGFDDDDADIDDEMVSLATIGACLVDWTDPRKVYTPDAGGLQAEKHVNADVHLDFAKAILERLEGNVPREEKKVLASLLSKLYISPASSPDKTRETYRVVSAAVDTNLLPDTTSRNALYKIHVSLGKIVNALDGAVPSVETASVAGSTGTGIGTTTTAATGRRVTRGSVSAGSGTGAGRRSISRASSVSTNADRPASASAAVPGSKAASTIEEEEEKEQEEEEEEEEKEEKEEEEEEEEEENVDEETQLAMQLQADTTAAQSREGSVQIKREEDDSESEASDATVVRGSVGTGRRVKQEEDDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHV2</accession>
    <name>G0SHV2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DNA repair exonuclease-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0073480</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the OST5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the rad1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697604.1">
        <property type="nucleotide sequence ID" value="XM_006697541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHV2"/>
    <dbReference type="STRING" id="759272.G0SHV2"/>
    <dbReference type="GeneID" id="18261386"/>
    <dbReference type="KEGG" id="cthr:CTHT_0073480"/>
    <dbReference type="eggNOG" id="KOG3194">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035332_0_0_1"/>
    <dbReference type="OMA" id="WSQAYKF"/>
    <dbReference type="OrthoDB" id="337581at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00577">
        <property type="entry name" value="PCNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.70.10.10:FF:000014">
        <property type="entry name" value="DNA repair protein Rad1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003021">
        <property type="entry name" value="Rad1_Rec1_Rad17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007915">
        <property type="entry name" value="TMEM258/Ost5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10870">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10870:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05251">
        <property type="entry name" value="Ost5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02144">
        <property type="entry name" value="Rad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01245">
        <property type="entry name" value="RAD1REC1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS17022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="415" mass="45065" checksum="A52145A36EE5D9FC" modified="2011-10-19" version="1">MDSSLHEVWQAAAGSPFVPLVGKGSQFLVAFFLLLLGLSLGTAFALNRSLLNLPVLAFPASLALAFAISMDSQGSPTPLFRAVASSTRPLYQLLKAINFTNKVHVDITENGLRFAADHARVMQGVAHWNKTLFTSYTTNFPSNPPAEDASSEDDNEAAIPSFQISLPALLETLQIFGAVDAATRQAKADVDPYRSNLRNYRSDAFSAQTLGMSGTCSLSYPQEGGPFSIVLDEAGVSTTCNLTTYVPETPDDIPFNLEDISFKIITQARYILDALAELAPSNPEKLTIAASRSEPYLRFTSSGGALGSSTVDFAKGKDLLETFSVNGTNGRRKWMQTFKFDMIKAATEAMRIASKVSLRGDGQGVLSMQFMVEIEGCGPSFLDFRFVPYAVCEEEDEEENEEEVGESEEDDGDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHX8</accession>
    <name>G0SHX8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0073740</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697630.1">
        <property type="nucleotide sequence ID" value="XM_006697567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHX8"/>
    <dbReference type="STRING" id="759272.G0SHX8"/>
    <dbReference type="GeneID" id="18261412"/>
    <dbReference type="KEGG" id="cthr:CTHT_0073740"/>
    <dbReference type="eggNOG" id="ENOG502SFXK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017870_1_0_1"/>
    <dbReference type="OMA" id="WTAWPLK"/>
    <dbReference type="OrthoDB" id="5412288at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019622">
        <property type="entry name" value="Rrn9_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059095">
        <property type="entry name" value="Znf_C2H2_17_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10680">
        <property type="entry name" value="RRN9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26176">
        <property type="entry name" value="zf_C2H2_17_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="635"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="683"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="728"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="373"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
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        <location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="470"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="782"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="793" mass="89472" checksum="FFDFFB8356BE09DC" modified="2011-10-19" version="1">MDLDDDSQPSASVISHLPPPSHQPQQSHYPPYPSDDVAHPPRQATYYYPPRPNRWTGPPSTWLTHTAADRAVWTSLSNSRAQDLSIHLYNAYGLRKRLRKPPKVPGEDEDFNTEEGRWERKRQKQTEWAPPARWTAWPVRAGDVPGDGLLPEVRDGSEEFGVRRRRRELGLEGDGFAGGELEEEISAAVLRAAGVRFRKRGLEQQEAKEGGQVMESAEQRNATEAETDGWVTGDEGYVRMGKEKKPIGRPRKKRGSSPDYVPTLCADDDRNYALVRPAVRRIMAKLDDTLMILHNARVAGLRNMSESDSDGEDEDDDESTKQEAESEGEKLATEAESNEDNDDDDNDDDDDDEEEEEEEEKEEKPSVPASLRPRNRGGRPRKKHVPLEGETEEEMLIRIARQNHRKVPTFNNNEASTSRCRSTTRKPRNTHTKSEPESETDTRRGRSRSRKPVKSISQSRSKSTTRFPSKRPASSRSTSRSTSHSRSSSASDYGEKRLGRWGLRDWRDVLGAAALAGFEPAVLARAAQRCANLFGEEMVLHTLREQPVNDGEGTGVVGGSGIETVRYVPGGRVGLDEDWEESEEDFEEVLAQRRTVARQPSLSVEPGNTSEGSRGRSRSQSRPRGRSQTPALQSLVCPHETCYRSRHPFTRRDHLLRHLRMTHGEQPERSRTRSRSRTPGPGHRCPHADCDRAVDGFSRRTNLVRHLRLVHGDSGQNMGQGMGMVTGDEEEEEDSADEVEGGVHVDRFLKPIKPRKGWRAEDKGPKRVVKRRRGGKKRRCDEESEELDTFLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHY7</accession>
    <name>G0SHY7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Folylpolyglutamate synthase</fullName>
            <ecNumber evidence="17">6.3.2.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Folylpoly-gamma-glutamate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Tetrahydrofolylpolyglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CTHT_0073840</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10580"/>
            <dbReference type="Rhea" id="RHEA-COMP:14738"/>
            <dbReference type="Rhea" id="RHEA-COMP:14740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:141005"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </cofactor>
        <text evidence="17">A monovalent cation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 17">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.17" evidence="17"/>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697639.1">
        <property type="nucleotide sequence ID" value="XM_006697576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHY7"/>
    <dbReference type="STRING" id="759272.G0SHY7"/>
    <dbReference type="GeneID" id="18261422"/>
    <dbReference type="KEGG" id="cthr:CTHT_0073840"/>
    <dbReference type="eggNOG" id="KOG2525">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015869_0_1_1"/>
    <dbReference type="OMA" id="LMSYHVF"/>
    <dbReference type="OrthoDB" id="5212574at2759"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.10:FF:000009">
        <property type="entry name" value="Folylpolyglutamate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.20:FF:000031">
        <property type="entry name" value="Folylpolyglutamate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023600">
        <property type="entry name" value="Folylpolyglutamate_synth_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF5">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038895">
        <property type="entry name" value="FPGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="13 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 17" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="19">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR038895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR038895-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR038895-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGS17057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="494" mass="54405" checksum="3C7C577399C0880F" modified="2011-10-19" version="1">MAMASRTYNDAIDALNTLQTPYAVIEARRKAGIRPDAASVREMRGYLARIGYSPKDLDRLNIVHVAGTKGKGSTCAFVDSILSRYQRSGKGPKKIGLFTSPHLIAVRERIRINSTPLSEELFAKYFFEVWDRLEANSSVASDMVAPGSKPIYARYLTLMSFHVFLSEDVEACVYETGIGGEYDATNVVERPVATGITTLGIDHVFVLGDTVDKIAWHKAGIMKRGSPAFTIEQVPEADKVLRDRAVEKGVDLTVLGVDPRLEGVNIRPDALFQKKNASLAIALAEAALKRLNPSFERNPERLPQEFIEGLEQVVWRGRCEVKSEDRVIWHVDGAHTVDSLKMAARWFAGECAARPDGGPKVLIFNQQGRSEAVGFLEGLCNTIKKADPTGKGFEHVIFCTNVTYAATGYKRDFVNHQYNPEDIQKMTQQKLFAEKWSSLDPSANVMLIPSIEEAINKARELAESAGGPQWQALITGSLHLVGGALGILERADAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0SI24</accession>
    <name>G0SI24_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0074230</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697676.1">
        <property type="nucleotide sequence ID" value="XM_006697613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SI24"/>
    <dbReference type="STRING" id="759272.G0SI24"/>
    <dbReference type="GeneID" id="18261461"/>
    <dbReference type="KEGG" id="cthr:CTHT_0074230"/>
    <dbReference type="eggNOG" id="ENOG502TJKA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018311_0_0_1"/>
    <dbReference type="OrthoDB" id="61900at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS17094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="528" mass="60174" checksum="565035187CA17355" modified="2011-10-19" version="1">MEQVKTLVDKIEKEAGVERDIRDHHFQQSQYSVQHNFFKALIAQNRVECGLNRNQLELQLNSFEDQAYYYENLAATYRVTSQAWEPWFLVEQRHLPSTIPQPSSSPSTLSYKVTGGARLSQGLCDAPDYQHALQWSAQQRRLAPDIPSAYLVWAPGMTVHTALSSLIFQILQQRPTALFQFNMTPQAFLRGRQSVTVLWDMLKFLMASLGGCLLYLLIGSVGEDEFSIVECFYNAVKNWKDAPPIYVTIIHPYHERFVGLKEATDLDGLYDVHPSLTTTDALHHVLMVELGIHQVSETIEQLLWDAVWRETRYASIGVCLGKVVDHITAVAEQLGREEFKGDEDTMSFWMAGVRSWLENPGAADGLREQVQRHLNIVDLNLPEKVKENLSRHVKRLALKVDSQERKMVASHNMTDPQRHHVWDTMREAMSPALEVMFWGAIQELVEQALEAYCLSPAQSQLQAGRVVHKILEAKFGLMSNWRKTMTQEGESVIEGIETAIMIGFELTVKALTEPRRESEGQIAPDDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G0SI29</accession>
    <name>G0SI29_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0074280</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697681.1">
        <property type="nucleotide sequence ID" value="XM_006697618.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0SI29"/>
    <dbReference type="GeneID" id="18261466"/>
    <dbReference type="KEGG" id="cthr:CTHT_0074280"/>
    <dbReference type="eggNOG" id="KOG0269">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002874_1_0_1"/>
    <dbReference type="OMA" id="QTWRIVK"/>
    <dbReference type="OrthoDB" id="60955at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061700">
        <property type="term" value="C:GATOR2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037590">
        <property type="entry name" value="WDR24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200:SF1">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="170"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="266"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="432"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="628"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="687"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="791"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1267"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1346"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="492"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="504"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="628"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="687"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="802"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS17099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1372" mass="148511" checksum="090E5DCFC79A81DC" modified="2011-10-19" version="1">MYSIGMRKLLGKSNTDLTSHGSPPSGGRAGPAATAAAGGITSSPVVPNYRPAVSQDTVYAAGVPIACLDSSPDGRSAILGGRHVLKTVTVEGLTVREGLDLRSLLVAQPALRNNNPTSVADQLSVKAVKWGEVGGKQVLFTACTTGKVFMYDLVTVGSCGAGAPVDCVQMREDSRQVNALDINPHHSTWLLSGSQDGIVRCFDVRQRTETKTGATFRSKQAFKCHADGVRHVQWNPRDGFLFACATEQGNVIKWDMRKPNAPILRISAHEKACSAMAWHPDGVHLASAGLESRCYIWDMSKQDKRQKPKWTIATPSPAGTLAWRPGQWSATAQGKRTSQLAMSYDESGQKRSGINVVHVWDLARPTMPYKEIQRFDASPCAILWHDQYLLWTAGQDGIFAQCDVSFAPKVIDRQAVSTMAFSPRGDVMMLLDERAPPPRPRPHILHHDAAVPPASVPSVPSMTSYSSSPTTPRFSVSRSDSEDDAIGTFIGPRRRSSRRRRPSTRSTTTLSTTPPAGPSMEDVMSLEQTIKATGVYRPQQAMAVGHVPAAASPEVYEYLSANYLEALYRDLPGRPGSPPLPQRIATILDHYALAATHVRQFRLAQTWRIIAYAVDLMLHRRAQYHLERRRDRNQDSMRRKSSAKPKSLVGLSDHDNLPEMSVEKVQDDLVASRKPVSNLAVYDQSLQSKSVLPSEQESTSNMPTPMVRPVPNDTAGSQTDEADRESAASVVGEPSSFTLPPPAAYPPRQLLRSRLDSVPLSVVSHDSAATYASTEGYDFYDTEFLVKAADEARSASENSPDISRKQRQDSEVGSHAWSISDQSRRPTGLSEVEEGQAARAAIVAELQKSHAQELKSYEKTNQSPEKTKTAVPPRVPLERTETTMTGMTGFTSFTSYTDEHHLISQPTDLFGSPYASQTDINLRGSSILHSIPEPASPTRPEHDKSPFVIETDYLCWSDDPPYPYSSRTSSSSSALTSSPLHPYTIISRALAFETKTSALNASAMILLLKPLLPDDVINKHQAAAILRQHHSRLMGMKLFVEAALLRKLCMQGWPGGALSSWGDNYPAVLTPAQQGVQASFLCTSCNRPHDIDRSNPNLSPDALWRCARCRSVMAPCAVCGHRDTAPSMASASPLPTHIPAKHWANLTPQQQTTDENEPKLTTWFYCPSCSHGGHASCLQAWHAALDPDFSSSEPYLYLEDPPGAESSDGCCPVDGCGHTCLPSRWRNGDAVLLRGEEISRVTREASRALARGSAVASEVGAPSSSWVGGGAGSVVGDQAGGDHTGERSGDKVMPSGGGSGAGTGALVRSDVNDVPQSRAVETVREALASAGSYVGQGAKVGTSILSSSPGRNVISGDRERRKSVKFVADERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G0SI48</accession>
    <name>G0SI48_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0074480</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697700.1">
        <property type="nucleotide sequence ID" value="XM_006697637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SI48"/>
    <dbReference type="GeneID" id="18261486"/>
    <dbReference type="KEGG" id="cthr:CTHT_0074480"/>
    <dbReference type="eggNOG" id="ENOG502T96P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_773870_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="358" mass="40643" checksum="C24240E69D3339B9" modified="2011-10-19" version="1">MNRLRALLKRPKDSSSILGEATTIVTPLQNDPEPNFPPGPWQAHLPCVHAPRHGCKRHNPRNHDIFFDASLFPEKDKGKVGKVMKKRLGGDIPEEYSIPEVHMGEDVPKWTELLPRVHCEVPWDLGYYHVKWLSHNPPTNTLESIASSPLHCIATLPSTNPPLTLVTRTLVIQSRVLLQTYFCFPLAELDLGPAWSNGRVPPPGVFSRTFAKNAFIGRGFQEFYPCYTDTVVEIESVIYPDGNRGLLVGIDITKDLGTGREPWEQEWIAQVEGKFTWAIKRSEEDFLRMKREFEKAGDEIEIAQKEMREWETQKEKNEVGNKEQQSIGEKAKGEKGQEEEKQKDKRGEGVRRAGGNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0SI50</accession>
    <name>G0SI50_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0074510</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697702.1">
        <property type="nucleotide sequence ID" value="XM_006697639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SI50"/>
    <dbReference type="STRING" id="759272.G0SI50"/>
    <dbReference type="GeneID" id="18261489"/>
    <dbReference type="KEGG" id="cthr:CTHT_0074510"/>
    <dbReference type="eggNOG" id="ENOG502SM9E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022448_0_0_1"/>
    <dbReference type="OMA" id="VAEFWIM"/>
    <dbReference type="OrthoDB" id="5313079at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08734">
        <property type="entry name" value="RGS-like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF268">
        <property type="entry name" value="RGS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="418"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="619"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS17120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="661" mass="74807" checksum="0BB0F2823AE7254B" modified="2011-10-19" version="1">MALRAESPDSKPPVLGSEFGTTPDTKPEARYDVVGIWWLTWCGAWTLILAWGMIFLYRKRHTPPIRLRSLSLTFAGIILLHLYWVSVMIAYTYGPLAPEIAEYWVMGIWYPFGIALFQASNSQFLHVAKAQSRFAKPMKISEKLDEKREEERKGWFSSLRGMEYPKRMFLFVTMGMGVQLVVVVIIYLISRKFHPEFGIPGTEVYGSTPQEIAMKQGRSWEWWPSIVWQFIWAWIYAPIILWKSRGIRDTHGWQHQTVACCIAGLPAAPMWLIALYVPGMAPVNRYFVPPQWIATSVWFLEIFTIFVPCWQVRKHERLRHASLESIANWETKKQYISSRKSSTTESTCIPPLSPTSTKVAEGGQQTGPDAWKKLPSVESGDKETKHLSFDSLGLNLPDESILTMAALEKVLDQNPEPLREFSARRDFSGENIAFLTAVSEWKASLPKQFVDKRYEISPEVLRQVYTKALRIYTEFISPKDAEFPINIAWADLRKLQGIFERAAHAMAGEKKSFVDAATPFAEDDWKPSARTAVTPVANRNWKDSESLILPQRGNLNKSEAVGDVIALGSPQGNSGESLYQGDIPQAFDANVFDAAQASIKYLVLTNTWPKYVRERRNSESSSRSGGSSNGSGATENGERGRRRFRGFGLGFLRGRGEIAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0SI53</accession>
    <name>G0SI53_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small nuclear ribonucleoprotein G</fullName>
            <shortName evidence="9">snRNP-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0074540</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="13 14 15" key="2">
        <citation type="journal article" date="2025" name="Cell Res." volume="35" first="296" last="308">
            <title>Structural insights into spliceosome fidelity: DHX35-GPATCH1- mediated rejection of aberrant splicing substrates.</title>
            <authorList>
                <person name="Li Y."/>
                <person name="Fischer P."/>
                <person name="Wang M."/>
                <person name="Zhou Q."/>
                <person name="Song A."/>
                <person name="Yuan R."/>
                <person name="Meng W."/>
                <person name="Chen F.X."/>
                <person name="Luhrmann R."/>
                <person name="Lau B."/>
                <person name="Hurt E."/>
                <person name="Cheng J."/>
            </authorList>
            <dbReference type="PubMed" id="40016598"/>
            <dbReference type="DOI" id="10.1038/s41422-025-01084-w"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.80 ANGSTROMS)</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a role in pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697705.1">
        <property type="nucleotide sequence ID" value="XM_006697642.1"/>
    </dbReference>
    <dbReference type="PDB" id="9L5R">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="g/k=1-82"/>
    </dbReference>
    <dbReference type="PDB" id="9L5S">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="k=1-82"/>
    </dbReference>
    <dbReference type="PDB" id="9L5T">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.50 A"/>
        <property type="chains" value="k=1-82"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SI53"/>
    <dbReference type="EMDB" id="EMD-62841"/>
    <dbReference type="EMDB" id="EMD-62842"/>
    <dbReference type="EMDB" id="EMD-62843"/>
    <dbReference type="SMR" id="G0SI53"/>
    <dbReference type="STRING" id="759272.G0SI53"/>
    <dbReference type="GeneID" id="18261492"/>
    <dbReference type="KEGG" id="cthr:CTHT_0074540"/>
    <dbReference type="eggNOG" id="KOG1780">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_10_1_1"/>
    <dbReference type="OMA" id="MSKAQPP"/>
    <dbReference type="OrthoDB" id="2146at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034719">
        <property type="term" value="C:SMN-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01719">
        <property type="entry name" value="Sm_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000019">
        <property type="entry name" value="Small nuclear ribonucleoprotein G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034098">
        <property type="entry name" value="Sm_G"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF2">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="13 14 15" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="3"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS17123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="9L5R"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="9L5S"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="9L5T"/>
        </source>
    </evidence>
    <sequence length="82" mass="9246" checksum="28B836DFC4A98EE2" modified="2011-10-19" version="1">MAPAQPELKKYLDKRLFVELNGSRRVIGVLRGYDVFLNIVLDDAVEERPNGEKVKLGMVTIRGNSVVILEPLERIGDDRPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2023-02-22" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>G0RXU6</accession>
    <name>G0RXU6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0000430</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988030">
        <property type="protein sequence ID" value="EGS24112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690598.1">
        <property type="nucleotide sequence ID" value="XM_006690535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RXU6"/>
    <dbReference type="GeneID" id="18254081"/>
    <dbReference type="KEGG" id="cthr:CTHT_0000430"/>
    <dbReference type="HOGENOM" id="CLU_2654280_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS24112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="76" mass="8705" checksum="F97BA947E2263362" modified="2011-10-19" version="1">MPFTLLSPSTSYRWVFTTIEFLFTVSISTLSGNNNWRDAEGEGDRKGTKNRHHQAEVRILQSEFVLTALLFVMTIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYE2</accession>
    <name>G0RYE2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0006380</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.3.2.9" evidence="1"/>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691170.1">
        <property type="nucleotide sequence ID" value="XM_006691107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYE2"/>
    <dbReference type="STRING" id="759272.G0RYE2"/>
    <dbReference type="GeneID" id="18254676"/>
    <dbReference type="KEGG" id="cthr:CTHT_0006380"/>
    <dbReference type="eggNOG" id="ENOG502S3WQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048475_1_1_1"/>
    <dbReference type="OMA" id="EVMRKSI"/>
    <dbReference type="OrthoDB" id="2924818at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017939">
        <property type="entry name" value="G-Glutamylcylcotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935:SF0">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13772">
        <property type="entry name" value="AIG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS23928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="217" mass="24609" checksum="AD038398FB10B804" modified="2011-10-19" version="1">MGNGRYLYFAYGSNLWVEQMDNRCPGQNRIAGIGRLPGYTWFINERGYANIAPVTINQSGKSESQGSVSRFDSEVWGVIWELEEKGLASLDINEGAPHIYERRTMNVELWSAFGPIWPGDVTESTPTDLSAHTCPMVVYIDVKRAKGGYPPKEEYVVRMNRGIRDAIGMGIPKGYVERVLRRYIPPLEDLMVDEKTEKLAWKQAKNFQDEPEVATLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYE5</accession>
    <name>G0RYE5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2470 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0006410</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691173.1">
        <property type="nucleotide sequence ID" value="XM_006691110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYE5"/>
    <dbReference type="GeneID" id="18254679"/>
    <dbReference type="KEGG" id="cthr:CTHT_0006410"/>
    <dbReference type="eggNOG" id="ENOG502RZUI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081019_0_0_1"/>
    <dbReference type="OMA" id="VECFFFD"/>
    <dbReference type="OrthoDB" id="5553410at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.10">
        <property type="entry name" value="PNP-oxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019595">
        <property type="entry name" value="DUF2470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037119">
        <property type="entry name" value="Haem_oxidase_HugZ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37783">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04315)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37783:SF1">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04315)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10615">
        <property type="entry name" value="DUF2470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2470" evidence="2">
        <location>
            <begin position="11"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="258" mass="29392" checksum="83DED7D8CB61ECE1" modified="2011-10-19" version="1">MAHTIDPTSKADTLRHMNDDHTRDMALILAHYLSKTDPSSSKTKPFDLLNKYASSIKMTEINLDFLVLCVGEEEACYRIPFEPPLSSWNERRSRLVALVRAAREGLGVSEEEFPGGSDKTTTQGMVTVDEYMPPRFPIDMTILFLVVGYYAIYALLRAGWFEESELGKTVVSSVIAPFFPGGWDGFRWLTETIFIPVVGIHTAEAWWLDRTRLSRYGVKRGSLVWLLWIASALAEGRMTFVRFDTVVERKRRAVERSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYH9</accession>
    <name>G0RYH9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Chromatin modification-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0006750</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ING family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691207.1">
        <property type="nucleotide sequence ID" value="XM_006691144.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0RYH9"/>
    <dbReference type="GeneID" id="18254713"/>
    <dbReference type="KEGG" id="cthr:CTHT_0006750"/>
    <dbReference type="eggNOG" id="KOG1602">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1973">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005201_0_0_1"/>
    <dbReference type="OMA" id="ETIDSHM"/>
    <dbReference type="OrthoDB" id="4173905at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016094">
        <property type="term" value="P:polyprenol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291:SF43">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT DHDDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="9">
        <location>
            <begin position="1339"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="221"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="437"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="676"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="473"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="486"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="680"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="828"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="868"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="884"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="905"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="958"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="979"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1002"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1023"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1073"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1111"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1156"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1168"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1227"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1291"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1321"/>
            <end position="1336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS23965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1398" mass="148134" checksum="F993170C2C8A9C67" modified="2011-10-19" version="1">MSDLYLSRLRSWFLKSPPAEWGLNILRETLIGALRQGKIPRHVAFEMDGNRRYARSHKIETIEGHHLGFEALARILEVCYKCGVEVVTVYAFSLENFHRPKYEVDGLMQLAKLKLEQIVQHGELLDRYGASVRVLGRLDLVPPDVLEVVERAVAATAHNTDCVLNICFPYTSREEMTTAMRHTVEEYATTAPAQPTPFSQNRIKQKILSKKGEKLEALAAINELSPPPTPSTRSVDEHEDDAVSEATTLHSDSHTHKSTISTTTDDGSVAVYPNPETITPETITQHLYTAGCPPLDIFVRTSGVERLSDFLLWQAHQDTQIFFLKCFWPEFDLWHFLPVLLEWQWRQKQKERDERPAMVRRRPVVTYQNAWFSAWPHFDPPQPANPKPHGCWQPSVSAGVAAVDRVHPGLSPVSPVAGREKLPSSCLGTCALRPLTMKTAKPPAPEPSTTSTAAAAAAAGSSTTTTSRRAQPVRQTRINPQRSATLNRSNNPLSSSNAPAPEQPINILPGVTHFADAISALPRELVRHFTLLKEVDAKIFAPEETLFQLLDDALNTPVPDIPRQQNTDASNSAVANAHRHANASIFGLFQPPPMDPPEVFDPANLPRRKLFHETAMKIQELLVSLEEKNHVIATANDVLNKQLARIEEIWPHLEAEFSDEAKWGSTTHWAYIDNRQQQKANEKQAERSRRDGAAALSAAAEKLAEDAASRGSGKQGAGKKGGASKNAGNDDTDKNQDSAGTGKKGAGAKSRKPLPDSQPVGLGISNAGSGTTASKRRKTENAKSNGGTPTERAMSTVYGSGAKQRTTSPRETPAPEGGTGKKRKALPTASNQTKKSRTNATASPSVTSSPVLGNLPEPGTNTNKTSRASPAPSQSGAASGNGPTTRPVSSRGRQNSTAGADKRPPSSTAPSNKNGSVPGTPDLNGQSNGTRTAAGETKTGGKKGAAASNKASPVENNPDGEETLELMDDATAQDGGGDDNNKKDPKLEQEDQQQDEKKEGVATAAAAAAAAGGTTANLTIQPASASSAAAAAPTSGSNTTITGTKTKSGRTSKPSTPAIGSFPDNGASGAGIGAVSSSSSSAGTAAAGAGSSRGGRNSRNGENGGNGVGSGASNSTLGNAAAAGGASASASGNGSGSTAKRGHKKGTASISQPSAGEKDKDSDKKDSSASSSGGSTSGKQAKGVGADDKSDTGSNKQTHAGGQKDYHHHSGKGGGSQGKESKKRSGKNAQAAAAAAAAAVAHVDPDGDEEMPDAEQQGHQQDEQSQDGAASNNNGGGHTSTRRSTRREANHNNNNNNSNSNSHNSSSKYQQQQQQQQQQEEVAEEEVEEVEEEVEEDEPRYCICNGVSYGEMVACDGEGCPREWFHLECVGLRVAPRVNAKWYCEDCKKRLKIGEGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYQ1</accession>
    <name>G0RYQ1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GB1/RHD3-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SEY1</name>
        <name evidence="11" type="ORF">CTHT_0007480</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="8">Enriched in the cortical ER. Concentrated in punctae along the ER tubules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS24037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691279.1">
        <property type="nucleotide sequence ID" value="XM_006691216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYQ1"/>
    <dbReference type="STRING" id="759272.G0RYQ1"/>
    <dbReference type="GeneID" id="18254786"/>
    <dbReference type="KEGG" id="cthr:CTHT_0007480"/>
    <dbReference type="eggNOG" id="KOG2203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011270_0_0_1"/>
    <dbReference type="OMA" id="PIIKMTE"/>
    <dbReference type="OrthoDB" id="1597724at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016320">
        <property type="term" value="P:endoplasmic reticulum membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01851">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000727">
        <property type="entry name" value="Protein SEY1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03109">
        <property type="entry name" value="Sey1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030386">
        <property type="entry name" value="G_GB1_RHD3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008803">
        <property type="entry name" value="RHD3/Sey1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046758">
        <property type="entry name" value="Sey1/RHD3-like_3HB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45923">
        <property type="entry name" value="PROTEIN SEY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45923:SF2">
        <property type="entry name" value="PROTEIN SEY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05879">
        <property type="entry name" value="RHD3_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20428">
        <property type="entry name" value="Sey1_3HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51715">
        <property type="entry name" value="G_GB1_RHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="1"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="8">
        <location>
            <begin position="761"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="764"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="785"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="domain" description="GB1/RHD3-type G" evidence="10">
        <location>
            <begin position="47"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS24037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="859" mass="95858" checksum="9EA4C0E7E7E0B0DD" modified="2011-10-19" version="1">MNGHFSAVGDAPAANNFTHGIQVIDEDKAFNANLNDYLTETNVAKAGFNYHLISVFGSQSTGKSTLLNHLFGTNFDVMSEVERRQTTKGIWMAKNKRIAAEGNEDKMADNILVMDVEGTDGRERGEDQDFERKSALFALATSEVLIVNIWEHQVGLYQGANMGLLKTVFEVNLQLFLKDRQSQTRSLLFFVIRDHIGNTPLANLRNTLIQDLTRIWSSIAKPEGLENSKIEDYFDFAFAALPHKILQPERFQEEVQKLSTRFKEGYRSSKDQELEGGVFLPEYHRRIPADGLSVYCKGVWDQIVNNKDLDLPTQQELLAQFRCDEIAREVLVGFDAVIVPLEEQQADAARQGKPGIIPNLGTTGGGAREKCVKAFEIQASRYHKGVYSTKRAELESKIDARLKAIYTTHLTDVHKAGIASFSDAVTAAVKAGQKAGGAYEFAMIVSQQKEKSLDAFRKEAQSLLIEGVAWTNFGPQLRLFEKELDEVSARLRKEELRRLAARVERSVKTRLGDAVGLEFNKLGTGRGGSGAPETGEKPASEKDLWDRVWKVFTDIVDDAAAKFADRAKSFQASEEEVAVGIWRLRRKSWIALRERIDEEMQEGNILMKLRENFEDKFRYDADGVPRIWRPTDDIEGVYTKAREATLALIPLLAKIKLVATGAAPDLVAFIGAQPAGVDIREEDDLVPIGGIDDEDGKTLDDEMAVLSESKRQDLVARFKKMADGVYVEAKRSAIGGITQVPFYFYVAMLVLGWNEFVMVLRNPVLFMMLLIVTGGLYVAYSLNLLGPMMQMANAATNQAVEIGKDKLRQFIAENDRVRQAIGVPARQENGHYQNGGAVHLDRLDSRGKKVASQESDDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYS1</accession>
    <name>G0RYS1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">26S proteasome regulatory subunit 8 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0007690</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS24057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691299.1">
        <property type="nucleotide sequence ID" value="XM_006691236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYS1"/>
    <dbReference type="STRING" id="759272.G0RYS1"/>
    <dbReference type="GeneID" id="18254807"/>
    <dbReference type="KEGG" id="cthr:CTHT_0007690"/>
    <dbReference type="eggNOG" id="KOG0728">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_2_0_1"/>
    <dbReference type="OMA" id="REPAVIF"/>
    <dbReference type="OrthoDB" id="1664597at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000006">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000068">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="165"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="11"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS24057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="389" mass="43499" checksum="D7630AEB0BC5D94A" modified="2011-10-19" version="1">MALDNYYQNKIEAMRLEIIKGQAVLRRLEAQRNDYNSRVRLLREELGLLQQPGSYVGEVVKVMSTKKVLVKVHPEGKYVVDVADSVDVSKLTPGKRVTLLSDSYKLEKILPSSVDPLVSLMMVEKVPDSTYDMIGGLDQQIKEIKEVIELGLKHPELFESLGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCKFIRVSGSELVQKYIGEGSRMVRELFVMAREHAPSIIFMDEIDSIGSSRVEGSSGGDSEVQRTMLELLNQLDGFEPTKNIKVIMATNRLDILDPALLRPGRIDRKIEFPPPSVEARADILRIHSRKMNLTRGINLTKIAEKMNGCSGAELKGVCTEAGMFALRERRVHVTQEDFELACAKILNKHDDKEVSLAKLWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZ50</accession>
    <name>G0RZ50_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein bL32m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0001710</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690720.1">
        <property type="nucleotide sequence ID" value="XM_006690657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZ50"/>
    <dbReference type="STRING" id="759272.G0RZ50"/>
    <dbReference type="GeneID" id="18254209"/>
    <dbReference type="KEGG" id="cthr:CTHT_0001710"/>
    <dbReference type="eggNOG" id="KOG4080">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129084_0_2_1"/>
    <dbReference type="OMA" id="THLNRCP"/>
    <dbReference type="OrthoDB" id="2014905at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051991">
        <property type="entry name" value="Mitoribosomal_protein_bL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_bL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21026">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21026:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL32M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS23478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="137" mass="15283" checksum="201649C94ABBB69A" modified="2011-10-19" version="1">MAAVPLRIAGTGSLFPRLLPSTMFWATRMQLYVRQFALPFALPAVPVAGWQIGLPGSVKELLQDIWEGILKAVPKKKTSHMKKRHRQMAGKALKDVTSLCKCPACGELKRMHYLCPHCANKLRGLMNEEIKAKQNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZ83</accession>
    <name>G0RZ83_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0002050</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RENT3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690753.1">
        <property type="nucleotide sequence ID" value="XM_006690690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZ83"/>
    <dbReference type="STRING" id="759272.G0RZ83"/>
    <dbReference type="GeneID" id="18254243"/>
    <dbReference type="KEGG" id="cthr:CTHT_0002050"/>
    <dbReference type="eggNOG" id="KOG1295">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018549_0_0_1"/>
    <dbReference type="OMA" id="TVEFATY"/>
    <dbReference type="OrthoDB" id="18087at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12455">
        <property type="entry name" value="RRM_like_Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039722">
        <property type="entry name" value="Upf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005120">
        <property type="entry name" value="UPF3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112:SF0">
        <property type="entry name" value="FI21285P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112">
        <property type="entry name" value="UPF3 REGULATOR OF NONSENSE TRANSCRIPTS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03467">
        <property type="entry name" value="Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="557"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="210"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="630"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="236"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="284"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="359"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="474"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="534"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="630"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="739"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="750"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="780"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS23511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="805" mass="86070" checksum="6D6CC49020471EE0" modified="2011-10-19" version="1">MATPVLLSRRANGATATQTNDESKAPKAKPPPQGEKIVIRRLPPGMTEDEFLKILGDEWKPGNGKVDWLTFWPGKVSQHPSKPSRPARAYLHVIQRDLLPALLQTVQGAKWEDAKATWDDPALISPPTVEFAVYKKIPGDKKRVDSKQGTIDSDPEFMAFLEALANPDAVKETRPELETSAEEAAKNAVVTTTPLIEYLKEKRAAKAKELAAAKSAAKHARQESQNTKGKGAAAADDSKKKSKDGRGDRDRDRDRDRDRDRDRDRDRDRESERKPKESVKILTKKAASEAANKKAVAAAEAAAEAAKAAAAQLQQASQQNEKPSATEPLPKNRKAGIANAARILQRDLGLAPAKSARKARQEAAKSEAESKSTPSPKQGKEVSSKEATPASPAPAATHTPPSAQPSSSPTHEKGPSSTPAGKGRGKKRGGGPGGGDDDNKPKTNPKKDNKGEKSSEQVPPKPTMILKKNKDSQHQQQQNTSPSQAQPQHSTNQPQQQQQQRPSTQANKPQSPNNPKNTGGGGGGGQNPKKNEKQNQTANQNANPPSQQSSTPTPGATRAFIKHAPASQGVTDVLLREALSAFGTVTSVEIADRKKGFAYVDFAEPSGLAKAMAASPVAVAQAMVTVLERREMAGKKGKGEREKEGGKKDGQGHGKDKGEREREKKGRDQKGENNEEEKEKEREKEKEKEKEKEKEKEKEKEKEKEKEKQKQKENKAVVAAAGGEGQQQQGQAQGQGQGQHKRGGRRRGGRGREKDGKEGGKEGGGEGKESGGRGGSGHHGGKDGSGKKGGAEGAAAKGAPADNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZK4</accession>
    <name>G0RZK4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TRAM, LAG1 and CLN8 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0003270</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690874.1">
        <property type="nucleotide sequence ID" value="XM_006690811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZK4"/>
    <dbReference type="STRING" id="759272.G0RZK4"/>
    <dbReference type="GeneID" id="18254365"/>
    <dbReference type="KEGG" id="cthr:CTHT_0003270"/>
    <dbReference type="eggNOG" id="KOG4561">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034597_0_1_1"/>
    <dbReference type="OMA" id="AQWYNGM"/>
    <dbReference type="OrthoDB" id="10266980at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF0">
        <property type="entry name" value="TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="8">
        <location>
            <begin position="69"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="305"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS23632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="352" mass="39792" checksum="921CA4B912E72357" modified="2011-10-19" version="1">MRDPFPFAPIPALSKAVEPLADLLAFPTLPLHVHEVLGAALFYTLTHSVISPVVSNLFFSKYYPKHNRAKKANWDAHVVSLVQSVLINALALWTMFADEERKNMDFEQRVWGYTGASGMIQALACGYFIWDLGITLLNLDIFGVGLLAHAISALAVYSFGFRPYLNYYSSIFILYELSTPFLNIHWFFDKLNMTGSKPQLYNGILLLVTFFCCRLVWGTWQSVIVYGDMWRAIHEGPSAEYIKAAFSNPATANDPDVNLMYFARGAGPVPIWLAGIYVASNLTLNSLNWYWFYKMIHAVKKRFEPPKPGKKGPLPEAKATAVDSQEPVKRRRRPSIEDVVPDTEELRKGTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZK7</accession>
    <name>G0RZK7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0003300</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690877.1">
        <property type="nucleotide sequence ID" value="XM_006690814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZK7"/>
    <dbReference type="GeneID" id="18254368"/>
    <dbReference type="KEGG" id="cthr:CTHT_0003300"/>
    <dbReference type="eggNOG" id="ENOG502SS66">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1151681_0_0_1"/>
    <dbReference type="OMA" id="STYAWHA"/>
    <dbReference type="OrthoDB" id="5366256at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="241" mass="25124" checksum="9820EE46FBAB2797" modified="2011-10-19" version="1">MSTTTAISYDPGFSVGTRSAYPSWPGVDSGSSLVPPEYGAYGSDAGYTPPSGSRSVTASPPRIGLTPEQRELKRQHDQARHNAKLQIRGRRMESPASSVYSPPATLGDLTTSTTALPVYTTAPAQLPLLSEPPTQYMGPYNQPTPSMYATPYSPPQNTYLDYTSYPPPAAPSLPSQQYGLGVYHPVAQPYPAVTNANAAVAAAAAAAAAGSQSQQNQTNGTSGLGSTTPQNGQPTESANSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZY0</accession>
    <name>G0RZY0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0008020</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691332.1">
        <property type="nucleotide sequence ID" value="XM_006691269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZY0"/>
    <dbReference type="GeneID" id="18254840"/>
    <dbReference type="KEGG" id="cthr:CTHT_0008020"/>
    <dbReference type="HOGENOM" id="CLU_2158090_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="111" mass="12610" checksum="1D4663C61AB17C4D" modified="2011-10-19" version="1">MLPSKVLEPSLPDEFLELLRYLQAMLEHRRARDYGISPRGDVPFPRSAAERVLSYTHSRLNNNNHDNGQTPHSTSTQDLMRLANECTNGQSTFTSPSARRRTGMTRYGSMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0S055</accession>
    <name>G0S055_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0008800</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:48101"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="1"/>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691407.1">
        <property type="nucleotide sequence ID" value="XM_006691344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S055"/>
    <dbReference type="STRING" id="759272.G0S055"/>
    <dbReference type="GeneID" id="18254918"/>
    <dbReference type="KEGG" id="cthr:CTHT_0008800"/>
    <dbReference type="eggNOG" id="KOG1499">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017375_1_2_1"/>
    <dbReference type="OMA" id="HENMVRD"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000003">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000016">
        <property type="entry name" value="Protein arginine methyltransferase RmtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF116">
        <property type="entry name" value="PROTEIN METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="7">
        <location>
            <begin position="27"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="8">
        <location>
            <begin position="131"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS23216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="332" mass="37286" checksum="062FDB4C2DC19558" modified="2011-10-19" version="1">MLKDTIRTCAYRDFIYANKNLFRGKTVLDIGCGTGILSLFCARAGAARVIAVDNAAPILEKSRLNVFHNNLSDVITCISGRIEDVTLPVDKVDIIVSEWMGYCLLYEAMLPSVLYARDRYLKPGGLLVPSHASMWLAPVADADYVMDNIDFWRDVYGFDMSKAMQADIYRDGRVVTMPPSSVCGKPYAFRMLDLHTAKTEDLAFEDKWMSVLHDASEAAGERLDGFLVWFDIFFGESPTEKIDAATTAAEWVKHGRERVAFTTGPFGGETHWRQGLFLIDQEKAEEIEVEKGKKLEGTIEYAVAAGHARGLDIRVTWKHDSGKIQSQTWRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0B9</accession>
    <name>G0S0B9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0009470</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2015" name="Acta Crystallogr. D" volume="71" first="762" last="771">
            <title>A noncanonical PWI domain in the N-terminal helicase-associated region of the spliceosomal Brr2 protein.</title>
            <authorList>
                <person name="Absmeier E."/>
                <person name="Rosenberger L."/>
                <person name="Apelt L."/>
                <person name="Becke C."/>
                <person name="Santos K.F."/>
                <person name="Stelzl U."/>
                <person name="Wahl M.C."/>
            </authorList>
            <dbReference type="PubMed" id="25849387"/>
            <dbReference type="DOI" id="10.1107/s1399004715001005"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.14 ANGSTROMS) OF 287-422</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="journal article" date="2017" name="Cell Cycle" volume="16" first="100" last="112">
            <title>Interplay of cis- and trans-regulatory mechanisms in the spliceosomal RNA helicase Brr2.</title>
            <authorList>
                <person name="Absmeier E."/>
                <person name="Becke C."/>
                <person name="Wollenhaupt J."/>
                <person name="Santos K.F."/>
                <person name="Wahl M.C."/>
            </authorList>
            <dbReference type="PubMed" id="27880071"/>
            <dbReference type="DOI" id="10.1080/15384101.2016.1255384"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (3.20 ANGSTROMS) OF 426-2193</scope>
    </reference>
    <reference evidence="17 18 19" key="4">
        <citation type="journal article" date="2020" name="Structure" volume="28" first="236" last="243.e3">
            <title>Molecular Mechanism Underlying Inhibition of Intrinsic ATPase Activity in a Ski2-like RNA Helicase.</title>
            <authorList>
                <person name="Absmeier E."/>
                <person name="Santos K.F."/>
                <person name="Wahl M.C."/>
            </authorList>
            <dbReference type="PubMed" id="31859026"/>
            <dbReference type="DOI" id="10.1016/j.str.2019.11.014"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.80 ANGSTROMS) OF 473-2193 IN COMPLEX WITH ADP AND MN(2+)</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691471.1">
        <property type="nucleotide sequence ID" value="XM_006691408.1"/>
    </dbReference>
    <dbReference type="PDB" id="4RVQ">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.14 A"/>
        <property type="chains" value="A=287-422"/>
    </dbReference>
    <dbReference type="PDB" id="5M59">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="A/C/E/G=426-2193"/>
    </dbReference>
    <dbReference type="PDB" id="6QV3">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="A=473-2193"/>
    </dbReference>
    <dbReference type="PDB" id="6QV4">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="A=473-2193"/>
    </dbReference>
    <dbReference type="PDB" id="6QWS">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.30 A"/>
        <property type="chains" value="A=473-2193"/>
    </dbReference>
    <dbReference type="PDBsum" id="4RVQ"/>
    <dbReference type="PDBsum" id="5M59"/>
    <dbReference type="PDBsum" id="6QV3"/>
    <dbReference type="PDBsum" id="6QV4"/>
    <dbReference type="PDBsum" id="6QWS"/>
    <dbReference type="SMR" id="G0S0B9"/>
    <dbReference type="STRING" id="759272.G0S0B9"/>
    <dbReference type="GeneID" id="18254985"/>
    <dbReference type="KEGG" id="cthr:CTHT_0009470"/>
    <dbReference type="eggNOG" id="KOG0951">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000335_1_0_1"/>
    <dbReference type="OMA" id="MNPKEFN"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="BRENDA" id="3.6.4.13">
        <property type="organism ID" value="1279"/>
    </dbReference>
    <dbReference type="EvolutionaryTrace" id="G0S0B9"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000393">
        <property type="term" value="P:spliceosomal conformational changes to generate catalytic conformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18019">
        <property type="entry name" value="DEXHc_Brr2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18021">
        <property type="entry name" value="DEXHc_Brr2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000005">
        <property type="entry name" value="Pre-mRNA splicing helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000133">
        <property type="entry name" value="Pre-mRNA splicing helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000004">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000102">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000368">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000004">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000001">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000254">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000013">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041094">
        <property type="entry name" value="Brr2_helicase_PWI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048863">
        <property type="entry name" value="BRR2_plug"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21188">
        <property type="entry name" value="BRR2_plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18149">
        <property type="entry name" value="Helicase_PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="15 16 17" id="KW-0002">3D-structure</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="538"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="756"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="1388"/>
            <end position="1564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="196"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="528"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="530"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="533"/>
        </location>
        <ligand>
            <name>ADP</name>
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            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="554"/>
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        <ligand>
            <name>ADP</name>
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            <label>1</label>
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            <position position="555"/>
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            <label>1</label>
        </ligand>
    </feature>
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        <location>
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        <ligand>
            <name>ADP</name>
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            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="557"/>
        </location>
        <ligand>
            <name>ADP</name>
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            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="558"/>
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        <ligand>
            <name>ADP</name>
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            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="626"/>
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        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17 18">
        <location>
            <position position="663"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17 18">
        <location>
            <position position="664"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
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            <label>1</label>
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        <location>
            <position position="1287"/>
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            <name>ADP</name>
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            <label>2</label>
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            <name>ADP</name>
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            <label>2</label>
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            <name>ADP</name>
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            <label>3</label>
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            <name>Mn(2+)</name>
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        </ligand>
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        <location>
            <position position="1667"/>
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            <name>Mn(2+)</name>
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            <label>2</label>
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        <location>
            <position position="1728"/>
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            <name>ADP</name>
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            <position position="1915"/>
        </location>
        <ligand>
            <name>ADP</name>
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            <label>2</label>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS23280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="4RVQ"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="5M59"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PDB" id="6QV3"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PDB" id="6QV4"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="19">
        <source>
            <dbReference type="PDB" id="6QWS"/>
        </source>
    </evidence>
    <sequence length="2205" mass="250589" checksum="7E7C0C92693A3DFD" modified="2011-10-19" version="1">MSNKTTDYHRDVSQYKYSAMSNLVLQADRRFVTRRTDEPTGDPESLAGRLTVKDMGSRVIRSTAPKPKKSAMPDVERGSIREGADVLQQVKQKSRTETRGGGILSGADALIEGIRYRPRTQPTRDAFNLILTIVAEHLGDVPHEVVRSAADAVLEYLKDDDLKDFDKKKEIDDILGVSMSPKQFNELVNLGKKITDYDAQDEDEEGDEIQRAGEDEIDGRQGIAVDFGNEDDDGMVDVVRDESSEDEEEMDGEDEAEIQEMAQDQGNGEEAGLADDEAMVIDSAPDGKSKSQDKNYVHAREIDAYWLQRQIGRVYPDAHIQHDKTTSALKILSGEPDEPGGDEKQLRDIENDLMELFDYEHHELVQKLIENRDKVVWLTRLARAESREERDTIEREMASEGLRWILDELYGKPKDDQKKPKLEIKMDIDKDAFAAKEQALKQERPEGLVGGLQPKKLVNLENLVFDQGNHLMTNPRVRMPEGTTKRVFKGYEEIHVPPPKKRSDPTDQNIPVTELPEWARIPFNTTKTLNKIQSKCFPTAFLDDGNMLVCAPTGSGKTNVAMLTMLREIGKNRNEKGEIDLDAFKIVYIAPLKALVQEQVGNFGKRLEPYGIKVSELTGDRQLTKQQISETQVIVTTPEKWDVITRKATDISYTNLVRLIIIDEIHLLHDDRGPVLESIVSRTIRRTEQTGEPVRIIGLSATLPNYRDVASFLRVDFEKGLFYFDGSYRPCPLRQEFIGVTDKKAIKQLKTMNDITYQKVLEHVGQNRNQMLIFVHSRKETAKTAKYIRDKALEMDTINQILKHDAGTREVLQEAASSVNNTDLKDLLPYGFGIHHAGMSRADRTDVEDLFASGHIQVLVCTATLAWGVNLPAHTVIIKGTQVYSPEKGSWVELSPQDVLQMLGRAGRPQYDTYGEGIIITTQGEIPYYLSLLNQQLPIESQLVSKLVDSLNAEIVLGNVRNRDEGVEWLGYTYLFVRMLRSPGLYSVGAEYEDDVALEQKRVDLIHSAAMVLKKSNLIKYDEKTGKMQATELGRIASHYYISHESMDTYNKLIHPAMNDVELFRVFAQSGEFKYIPVRQEEKLELAKLLARVPIPVKESIEEPTAKINVLLQAYISRLKLEGLALMADMVYVTQSAGRILRAIFEICLKKGWASVAKLALNMCKMAEKRMWPTMSPLRQYPTCPAEIIKKAERMDVPWSSYFDLDPPRMGELLGMPKAGKTVCALVSKFPRVEIQGNVQPMTRSMLRIELTITPNFQWDVELHGVTESFWILVEDCDGEEILFHDVFILRKDLAEAEENEHTVEFTVPISEPMPPNYFISVISDRWMHSETRMPVSFQKLILPERFPPHTELLDLQPLPVSALKAKDYAALYPNWQQFNKIQTQTFNSLYNTDNNVLVAAPTGSGKTVCAEFALLRHWAKKDAGRAVYIAPFQELVDLRFQDWQKRLSHLRGGKEIVKLTGETTTDLKLLEQGDLILATPLQWDVLSRQWKRRKNVQTVELFIADDLHMLGGQMGYIYEIVVSRMHFIRTQTELPMRIVGLSVSLANARDIGEWIDAKKHDIYNFSPHVRPVPLELHIQSYTIPHFPSLMLAMAKPTYLAITQLSPDQPAIVFVPSRKQTRATARDLLTACLADDDEDRFLHVEVDQIRKLLDHVQEEALAEALSHGVGYYHEALSQSDKRIVKHLYNNGAIQVLIASRDVCWELDFTAHLVVVMGTQFFEGKEHRYIDYPLSEVLQMFGKALQPSKDGRSRGVLMLPAVKREYYKKFLNEALPVESHLHNFLPDAFVTEISTKMIESGEDAINWATFTYFYRRLLANPSYYGLQDPTHDGLSQYLSDLVETTLKQLSDARIIEMDEDEGTVAPLNAAMIAAYYNISYMTMEMFLLSLSHKSKLRTILEIVTAATEFESIQTRRHEEGILKRIYDHVPVKMNNPVWDSAHFKAFVLVQAHFSRMNLPIDLAKDQEVILQKILSLLSAIVDILSSEGHLNALNAMEMSQMVVQAMWDRDSPLKQIPNFTPEVVKVANKYGINDIFDFMEQMNPEENPNYASLVKDLGLTQAQLAQAANFTNNKYPDITLEFEVDDPDNIRAGEPAYLKIHIERELEEDEEFDPTVHAPFYPGKKSENWWLVVGEESTKTLLAIKRVTVGKELNVKLEFVVPSPGKHDLKLFLMSDSYVGVDQDPSFSVNVAEGMDVDEDEEEEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0J4</accession>
    <name>G0S0J4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0010230</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691546.1">
        <property type="nucleotide sequence ID" value="XM_006691483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0J4"/>
    <dbReference type="GeneID" id="18255061"/>
    <dbReference type="KEGG" id="cthr:CTHT_0010230"/>
    <dbReference type="HOGENOM" id="CLU_2385947_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="94" mass="10250" checksum="1406E3F89C67F50E" modified="2011-10-19" version="1">MPLPLLEPPTRRDTGVVEGPSNKAPTNESCETRRAGALHVEWMLFSAFAPLSGRSTGSYESRFPPSPLKVTPRRPGPSRQPRRQVPASATLGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1D3</accession>
    <name>G0S1D3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor 38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0013190</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="11 12 13" key="2">
        <citation type="journal article" date="2016" name="Structure" volume="24" first="1972" last="1983">
            <title>Scaffolding in the Spliceosome via Single alpha Helices.</title>
            <authorList>
                <person name="Ulrich A.K.C."/>
                <person name="Seeger M."/>
                <person name="Schutze T."/>
                <person name="Bartlick N."/>
                <person name="Wahl M.C."/>
            </authorList>
            <dbReference type="PubMed" id="27773687"/>
            <dbReference type="DOI" id="10.1016/j.str.2016.09.007"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) OF 2-220</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PRP38 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006691772.1"/>
    </dbReference>
    <dbReference type="PDB" id="5F5T">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.55 A"/>
        <property type="chains" value="A/B=2-220"/>
    </dbReference>
    <dbReference type="PDB" id="5F5U">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.75 A"/>
        <property type="chains" value="A/D/G=2-220"/>
    </dbReference>
    <dbReference type="PDB" id="5F5V">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="A/D=2-220"/>
    </dbReference>
    <dbReference type="PDBsum" id="5F5T"/>
    <dbReference type="PDBsum" id="5F5U"/>
    <dbReference type="PDBsum" id="5F5V"/>
    <dbReference type="AlphaFoldDB" id="G0S1D3"/>
    <dbReference type="SMR" id="G0S1D3"/>
    <dbReference type="STRING" id="759272.G0S1D3"/>
    <dbReference type="GeneID" id="18255357"/>
    <dbReference type="KEGG" id="cthr:CTHT_0013190"/>
    <dbReference type="eggNOG" id="KOG2889">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039466_0_1_1"/>
    <dbReference type="OMA" id="GEHFKYL"/>
    <dbReference type="OrthoDB" id="190958at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005037">
        <property type="entry name" value="PRP38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23142">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03371">
        <property type="entry name" value="PRP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="11 12 13" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="203"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="212"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS22843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="5F5T"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="5F5U"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="5F5V"/>
        </source>
    </evidence>
    <sequence length="257" mass="29543" checksum="999CC21C92F93FBB" modified="2011-10-19" version="1">MSKPDTHRADERRFLDERGSSGPLAPNGLNPATIMEKAVRERIVESYFWKEQCFGVNEADIVDRVVEHVRFVGGVTGVTQKPSPFLCLAFKLLQLAPGDDILKEYLYFGGEKFKYLRALAAFYIRLTRPDKEVYTLLEPFLEDRRKLRRKGKNGTSLTYMDEFIDDLLTKDRVCSTSLWKMRRRDILEDLDLLEPRVSPLGSLEDILEEEEQAAKNEDGERRETGQESLSNLATRHKPPRQVAERSAMPSSRPDTMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1H9</accession>
    <name>G0S1H9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">KOW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0013660</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691881.1">
        <property type="nucleotide sequence ID" value="XM_006691818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1H9"/>
    <dbReference type="STRING" id="759272.G0S1H9"/>
    <dbReference type="GeneID" id="18255404"/>
    <dbReference type="KEGG" id="cthr:CTHT_0013660"/>
    <dbReference type="eggNOG" id="ENOG502QUDZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041333_0_0_1"/>
    <dbReference type="OMA" id="TRHDPEY"/>
    <dbReference type="OrthoDB" id="359154at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003256">
        <property type="entry name" value="Ribosomal_uL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12903">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22682">
        <property type="entry name" value="Ribosomal_uL24m-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KOW" evidence="3">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="356"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="376"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="401"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS22889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="413" mass="47046" checksum="CA1AB10C3705219B" modified="2011-10-19" version="1">MDKILRRVRMAERQVARRNKERAFREYMQEKRNRRRTRAKLAAEVRLDIGYAIGRRHEDLEMGPITPNRDIMKVNRFGNYYGSISTSRALLDFPITEKEREARCAWAGGSKYLCLAPGDRVVITEGHLKGRITTIESIDRNLMTVELAADFTLVNATVPEYVREPGQSPVQLVKARFPISAIRLVHPVADPVTGVTRDVIIRELKPFGIVHDRVTRKVTWARFVPGQNIKIPWPKLEPKEKPEYAGDTLRIDMEERTFVPTLLRPPMPEQVIDELRNRYSKFRTRHTAEYIAEKEAEEAEKKARKKAADAMLLPIQEYNRRMRELRRARGQPVLTEGMLEKIGQIIAQNLARRQAAARPAPQPARVAGVTALTSSQEKRDESVEKLEKAVEQLSLGGDAATPSTPDQPTTSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1L0</accession>
    <name>G0S1L0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8032 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0013980</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691912.1">
        <property type="nucleotide sequence ID" value="XM_006691849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1L0"/>
    <dbReference type="STRING" id="759272.G0S1L0"/>
    <dbReference type="GeneID" id="18255436"/>
    <dbReference type="KEGG" id="cthr:CTHT_0013980"/>
    <dbReference type="eggNOG" id="ENOG502QY0U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014950_0_0_1"/>
    <dbReference type="OMA" id="YFPVQMK"/>
    <dbReference type="OrthoDB" id="5599902at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058345">
        <property type="entry name" value="DUF8032"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22949:SF0">
        <property type="entry name" value="RE27538P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22949">
        <property type="entry name" value="WHITE COLLAR 2 PROTEIN WC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26087">
        <property type="entry name" value="DUF8032"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8032" evidence="2">
        <location>
            <begin position="284"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8032" evidence="2">
        <location>
            <begin position="566"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8032" evidence="2">
        <location>
            <begin position="679"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="428"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="516"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="756" mass="83860" checksum="DD867D54440FFD77" modified="2011-10-19" version="1">MQHHTAHHQQQGPVPPLLQHSRPSSIVQQHHSQAPPQQPPQQQPQQPQTQHSSAYPYPPQSQTSSSQDHALSYYAHPSPYSTPGATSGYTSADTGDMMAATMPRPYPPMSYHTPQSNSPASVASPSGHDQQRGMYGQPPSQLHQQSLYYSAPQQQYSSMPAQAAQSPYAQHAQQPHQPMGSQPSMMMSHTAQQHQMSQHAPQHSQPGMTVSPRPDAKMDPHGLNHQMSRTSGPVAIGSSASTNAQNGGQVSTTTTSTSQVNSNAAPGPIPATTPLVVRQDTNGVQWIAFEYSRDRVKMEYTIRCDVESVNTDELSPEFKAENCVYPRACCPKEQYRGNRLQYETECNTVGWALAQLNPPLRGKRGLIQRAVDSWRNSNADPRLRSRRVRRMAKMQYRNQKAGLPATHNSQLPQTHNSQLPGTASTGMTTPAALPAATDPSMANSGLSSMPPQLHHHHTAPQTAATDGKTQGGDEVGEYPNDQQHHHHHQPPVQSGTDERPAQVFTGYGVYNGAPQASSSMSSIHDAMSGSHATTAARRTASSRRGSDDTPDDLFPDIPEAKKRKFILVEDSDRQSRLRVRVTLDGVDTREIPDSFRKSSSVYPRSYFPREMQSPPPSATGSKFFTDDASDYEDDGTTDTEGRRYTRINRRGRTMVKVPMAEGQEGEIAIPRMRKMFRGKEVRLNDLGYRMAWLQSRVFAGRTVFLQRALDCYRNKTRSAMESIMQDVKTTAPHYETRVGKRRFNERMRSGEKEDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1M6</accession>
    <name>G0S1M6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Oligopeptide transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0014140</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691928.1">
        <property type="nucleotide sequence ID" value="XM_006691865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1M6"/>
    <dbReference type="GeneID" id="18255452"/>
    <dbReference type="KEGG" id="cthr:CTHT_0014140"/>
    <dbReference type="eggNOG" id="KOG2262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004965_1_1_1"/>
    <dbReference type="OMA" id="AMIWPAD"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="276"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="530"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="588"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="658"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="683"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="705"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="733"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS22936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="798" mass="91181" checksum="BC36099AB5FA3334" modified="2011-10-19" version="1">MVMAFLRSLWRRRESAVVPDMDGSLEGESANFASLKHFEKMHRLDPNLPLDELEEVDIAFNTSNVEKGAEIEQILNEDNSPYPEVRASVRNFDVDMPVNTIRAWAIGMFLCTVGSAVNMLLSLRNPSISLTTFVIQLIAYPLGLLWDLIFPDRVWNVCGIKFNLKPGPFNFKEHVIIVVMSNAAYGGGALYSSDVIIAQRMWYGQDFGWLWQLLFSITTLCTGYGLAGIARRILVYPAAMIWPTDLVNCALFYTLHDHSPSDPTRTNGWRIGRYKWFLLVFAGSFLWYWFPGYLFQGLSWFCFITWIWPDNVIVNQLFGGYSGWGLFPFTLDWSIISGYLNSPLIPPFHAIANVITGVTIFFVIVSIGIHYSGLWYSAYLPVQNSHAYDNTGHIYNVSAILGPDLQFDEAKYKAYSPLYLPTQFALAYGLSFAAISAVITHVVLYHGREIWTQWKLARSQEDDVHMRLMKKYRDAPDWWYAVLFVIMVGLSFATVCAWDTNFPWWAYVVCMLIPIIWTIPIGIVQAITNIQLGLNVLTEFIVGYMLPGRPLAMMMFKNYGYLCMSQALYFVQDLKLGHYMKVPPRLMFWSQLIASIWSAIVQLAVMNWALATIPNVCSETQVHHWNCPSARVFYTASIIWGAIGPARMFSGDALYSSLQWFWLVGALAPVVTWFFARKYPRSLWRYVNMPLIFGGSLMLPPATVFIYYCWGIVGTIFNFFIRRRKTGWWLQYNYVTSSALDCGLIVSTLVIFFALYLSETEAPRWFGNVKVLQTLDMQNKAVQKTVPPGQTFGPSSWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>G0S205</accession>
    <name>G0S205_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0015510</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS23065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692057.1">
        <property type="nucleotide sequence ID" value="XM_006691994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S205"/>
    <dbReference type="GeneID" id="18255589"/>
    <dbReference type="KEGG" id="cthr:CTHT_0015510"/>
    <dbReference type="HOGENOM" id="CLU_2573672_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="81" mass="9147" checksum="618D03EA3FAD1359" modified="2011-10-19" version="1">MDRIEDHSSDSTTLFRLSGEGTRQGDQEALLRYLRSRDGPVTERLFELASRNYNDTNNAQVVQRPQQPQGQGGPNSQEQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2T7</accession>
    <name>G0S2T7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0018440</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692339.1">
        <property type="nucleotide sequence ID" value="XM_006692276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2T7"/>
    <dbReference type="STRING" id="759272.G0S2T7"/>
    <dbReference type="GeneID" id="18255882"/>
    <dbReference type="KEGG" id="cthr:CTHT_0018440"/>
    <dbReference type="eggNOG" id="ENOG502RXTA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014722_0_0_1"/>
    <dbReference type="OMA" id="QNCFRCY"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF6">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1996" evidence="1">
        <location>
            <begin position="155"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="471" mass="52071" checksum="3AFAAFCCB00E3249" modified="2011-10-19" version="1">MPATAALIGSRIRTTIYMDIAQSTGHQTRGLGTQIYNIATAVEPDLLKYQDRERFPSLRLINRRGDLSAPSPKGWLSHLKLIKSLFEILPTPADGLHTFSKELLTMRYISYLLALAARALAEPSPNPYPQFGFGGLNQMTMLRFGCANIVIDRIDPLVNPGQVPSPHIHQIVGGNAFNVTMPTDDVAEHATCTSCAFADDFSNYWTANLYFRARNGSYKRVPQGGHAYQFGDRFSTQTQGGILVYYVSAQPGRITAFKPGFRMLVGDPNMRSRSDTRLRRQNCYRCYTGPNFGGDVGAPCMDPAVDTEALPNKPCPGGIRSNIAFPTCWDGKNLDTPNHQDHVAYPVNGPADFLSLGGNCPSTHPVRIPQLMYEVVWDTTQFNDRSLWPEDGSQPFVLSTGDPTGLGQHGDYVFGWKGDSLQRAMDTAGCFGAQCANLRTQSIEEARRCTVKQAAREDYDKWLDKLPGVEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2T9</accession>
    <name>G0S2T9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0018460</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692341.1">
        <property type="nucleotide sequence ID" value="XM_006692278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2T9"/>
    <dbReference type="GeneID" id="18255884"/>
    <dbReference type="KEGG" id="cthr:CTHT_0018460"/>
    <dbReference type="eggNOG" id="ENOG502S75S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054223_0_0_1"/>
    <dbReference type="OrthoDB" id="5103225at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58100">
        <property type="entry name" value="Bacterial hemolysins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="358" mass="39172" checksum="DE6FBE27A5148FA6" modified="2011-10-19" version="1">MAATVDVPPPYDLDAPPSYESVVGKIDTLVKNDPTCDGAMKAFNGLSDAEKKVLISHDLDGIHFDPEQEKRFRRGFAEAFAKARDHLKWDAEGCANFCFDRVIIKIAADKSIPIDKRKETINNFIKDAEALEDKAKGIHDDFNKFLSAMTAYTGRFEAWAVSKEGALNKDIAELFEGITKLDSNISRLKAWLIGAFGLGTASVPALSLAVAAAGPWLPVIAAAGLVISMGTTTAMACLAAKITDFEQEKKKKEERIEEANMHISKIGKSRQELTKLGIVLQRDVARVVGIINTARQYCQNDAVEIMMWLEDGENEADLPKYMAFDLGQANGIYTVVGEYLKVYADCLANTSNPVTAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0S300</accession>
    <name>G0S300_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oxidoreductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0019130</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692402.1">
        <property type="nucleotide sequence ID" value="XM_006692339.1"/>
    </dbReference>
    <dbReference type="GeneID" id="18255951"/>
    <dbReference type="KEGG" id="cthr:CTHT_0019130"/>
    <dbReference type="eggNOG" id="KOG2395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_254790_0_0_1"/>
    <dbReference type="OrthoDB" id="10251113at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016670">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030328">
        <property type="term" value="P:prenylcysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010795">
        <property type="entry name" value="Prenylcys_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040458">
        <property type="entry name" value="Vid27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013863">
        <property type="entry name" value="VID27_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040979">
        <property type="entry name" value="Vid27_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040768">
        <property type="entry name" value="Vid27_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913:SF0">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07156">
        <property type="entry name" value="Prenylcys_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08553">
        <property type="entry name" value="VID27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17748">
        <property type="entry name" value="VID27_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17747">
        <property type="entry name" value="VID27_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409250" evidence="2">
        <location>
            <begin position="22"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="domain" description="Prenylcysteine lyase" evidence="3">
        <location>
            <begin position="206"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Vid27 N-terminal" evidence="6">
        <location>
            <begin position="585"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="Vid27 PH-like" evidence="5">
        <location>
            <begin position="827"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar import/degradation Vid27 C-terminal" evidence="4">
        <location>
            <begin position="1016"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="792"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="958"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="958"/>
            <end position="991"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS22383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1393" mass="154662" checksum="06D9DEF934307B62" modified="2011-10-19" version="1">MKLPLGSLGLNTLALLGLGAAQTQVAIIGAGAAGSSTAYHLSQYANDLGLNVNITIFEKENRIGGRTLTINPYGDASQVVELGASIFVQINQILYNAAQQFGLITIGQNSDSGVEGHLGVWDGDQFLFTLDERLPEWFNNLKVALRYGVTAPRRTQQLVASVIGQFLRIYQPPHFPFSSLTDVVANLGLTNVTGVSGEQFLNANGVSVAAEGAVQVLGGNWQIFQKMVEASGATINLNSPVIGLKKSGSKYAIQTISGSSNTTYQITFDKVILANPFQFSNIDVGSGVLTSSIESVPYVQLHVTIFSSSKRLKPQYFKWPGFLNVPTGILTTLAKADNANSGSQGVGKAGFFSCTILRTAINPATKKKEYIYKIFSPQALTPSLLSALFGQTVPDTFTGSGSPISWYYPHVFHSYPKAVPRTSFQDIIVGDGVYYTSGIEPFISTMETSALMGKNVARLIVDDLASGDSSQVKSRFGSNRFGAIRKQGPPEWPPRCTPLQLHKDQDSASVTAWCTTREESPLFHASGSKQTLRPVPLVWFDSGCRLFPILRLLRAPNIDGDDRFCSAPLPAVYQQKDKNTSAATMFVLRNVGKLLFGSSNQETLIELPQGQLYLVRPLSPKGYSELIFKDASARIRRTAQDFHYQLVVQRVYEEGEAELLAEEEGEDGGADADALGSERDEKTFLLDEALHFRVENREGSERVLAWRDLSGDAGDVYEFVCDASISSKQVQQFERIARECQYERKYRKPHTTASEEDLKQFEFADEPPIPQASPIHSPTLARSIDAIDDMALNKRDSSPEPPTPAKRGKERDMKPPAVSQHPKARELLAAEIAELHFFDFPSGTFVLQDASVTAKVMEIGDWEYWLEVSSADRDWLGIPVVAEINPVFNFEFLSFIFNQFTDDGSAYSWLLRFKDQPTLERFQQGLLQALWERLNEMKWSKIKDKERDYVADAFNDLAMEDSESVEEEEEEGRDEDGESEEEEEEEEEEDDRAQSEHYDSDEEQDDVDYKPKDGDVNKMLAVGYKHDRSFVVRGSKIGVFKHTPNNHLEFSTNISKVQTPKGELFSPKKVMLHNEDRNLILQKDNDPNKLYRMDLEYGKVVDEWTVHEDIPVVTFAPENKFAQMTSEPTFLGISRNALYRVDPRLPGSKLVDSQLKQYVSKNDFSALATTKQGYIAVASNKGDVRLFDRLGINAKTHIPALGEPIIGLDVSADGRWVLATCKTYLLLIDALQKSGKNEGKLGFEKSFAADAKPQPRRLALTPEHVAQFAYETGKGVSFTPAKFNTGEGAEETSIITASGPYIIEWSLKKVLAGKKAPYLIKRYTDDVKADDFKFGTDKNVIVALPHEVNMVSHARLKRPTRESIAGDFGRRTSARYATPGRSRLGRGDIVQEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3D5</accession>
    <name>G0S3D5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycoside hydrolase family 5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0020620</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692537.1">
        <property type="nucleotide sequence ID" value="XM_006692474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3D5"/>
    <dbReference type="GeneID" id="18256100"/>
    <dbReference type="KEGG" id="cthr:CTHT_0020620"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_263822_0_0_1"/>
    <dbReference type="OMA" id="GEACYLG"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408797" description="Glycoside hydrolase family 5 domain-containing protein" evidence="8">
        <location>
            <begin position="19"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="9">
        <location>
            <begin position="227"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="408"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="468"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="547"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="707"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="903"/>
            <end position="948"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS22518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1266" mass="140342" checksum="F9C8A0D3D3DEA079" modified="2011-10-19" version="1">MKFFNLLIGVAAAESALAAPAGGVLIPTRTQRRTPKSQFVGIDETGAEFGKDTLPGRLSSAGGIPFMMEGLVPNRSTGPVDNAYAPGLIDVCGALFVGMLEREETHNLLIVNHVTSKGAYAVLDSHNFGKKIPNCSPTMTKVTFYENNEYCDMDNQLVLRLSQAAIGRYPRRGSYFTANICRGQFTDRRLGLGTHTLASSPGVSLTIGIQVASGNALILLNLINPAAPDDSKIIYEMHQYLDIGGSGTSENCVSSTIDKQRLREAAAWLKANNRRASWAKRLAAPTPSLPGALKKALAVGADPNHEFCLSSIFIDIWEAAMKVYKTNVLWEKSNPAFWPALGLHLEENLVREYKQQARALTPTHTTFDVFAPTHPRGEGPFGEDDDDDEVRSYEKFYPGYGDSGECTRRFTALHIAAREGHSDIITLLLDHGADIESLSTNFCDCITSDGFMNDLGPDPWDTTLYEIQRWSPLHVAICSGHTEAAKLLVSRGAKAVYEPEPASDPSLPRPSKRKSPFAKAAALGQVDVLQRVLDTHPGFNVDQTDAAGLSALYYACYHRQWDTTVPFLLQHGANINHPVRVRWGRSTLLTNILGEACYLGQFRTALKLLDLGADPSVGIRVLDDRNDESQDPMDAEPDPGSGTYVPLPHLCCIRYLDLHRSPRSWGLPPPHYILSVEDSYRQQVIEKLLAAGLSLDTFWTWAPAHGYNHSPLTLAVQHLNDAAVKTLINAGAEVNACNSQGRNALMVAVAEVPSESVLRDPDHRRLSDSYWNLVPFQEWGLPFDHDYPNRPHIVSLLLEAGTPVNQQDLDGNTALHLLFDGYRDQSRPWMPLKSAKQILRLLLSKGADPFIRNNSGETPFQIAVRRECHYALDILARQSRIDPGDRLSMPEIVAMFRNAQPSNLRSSDFQEDDEYTDDLGQGYREDENEDGMYSSSDPDDERDSYTGMPSYTTMQVRKLQERSRQIFTFLLDVFSSKSLLSYPEFVDLCINDGKPQSPLLDLAVQQLYQGSLSHADLLTESKISLLLKAIVTKRWETAHVILDGFADHEKRTLVSTTQEELPLIRAIEAKAPASFAKRLLEAGFNAHQLLELPSSKGKFTTPLGEAIKSSNFGVVEAMLRLQPLPQPPLPEGTPHYLHWAVTAVLNNAYYNGVGSWEKPKRSARKQSRNILRALLAAGADTTQLNASGQTPFCYFVLSLTRQPSIVMDTYDLFKPLARGVDLHLKDALGYSALEYMEQLLSAKSALKQWVKILELEDGTKKIHWLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3T0</accession>
    <name>G0S3T0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]</fullName>
            <ecNumber evidence="3">1.3.1.124</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0030520</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a (2E,4E)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:45912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85101"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (2E,4Z)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:61892"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85099"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.3.1.124" evidence="3"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693502.1">
        <property type="nucleotide sequence ID" value="XM_006693439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3T0"/>
    <dbReference type="STRING" id="759272.G0S3T0"/>
    <dbReference type="GeneID" id="18257090"/>
    <dbReference type="KEGG" id="cthr:CTHT_0030520"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_2_1"/>
    <dbReference type="OMA" id="MQAHVCA"/>
    <dbReference type="OrthoDB" id="2136131at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008670">
        <property type="term" value="F:2,4-dienoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05369">
        <property type="entry name" value="TER_DECR_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045017">
        <property type="entry name" value="DECR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296:SF2">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE [(3E)-ENOYL-COA-PRODUCING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS21206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="320" mass="33602" checksum="1CC7123E10587C12" modified="2011-10-19" version="1">MSVPPRSEYLSHVWAKDIFANRVLFITGGAGTIGSAQTRAMVHLGADACIVGRSVEKTEAAAREIAKVRPGARVLGLGGVDVRNFESVKAAAERCVKELGAIDYVVAGAAGNFIAPLSGMSPNAFKTVIDIDTLGTFNTFKATIPYLVESAKRNPNPNPSGSTGGRFISVSATFHYTGMPLQAHVAAAKAAIDSLMGSVALEYGPFGVTANSIAPGAIEGTEGMERLASSKVSKRDRTKGVPLGRWGTVRDIADATVFLFSDAGSYVNGTTLIVDGAGWRRQGGSLGVGLDPGMEYPEFLLQGTFSKFVKDGRKKDKVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3X0</accession>
    <name>G0S3X0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial K+-H+ exchange-related-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0039170</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS22032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694328.1">
        <property type="nucleotide sequence ID" value="XM_006694265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3X0"/>
    <dbReference type="GeneID" id="18257955"/>
    <dbReference type="KEGG" id="cthr:CTHT_0039170"/>
    <dbReference type="eggNOG" id="KOG4539">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043838_2_0_1"/>
    <dbReference type="OMA" id="PFFYLAY"/>
    <dbReference type="OrthoDB" id="5562676at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018786">
        <property type="entry name" value="Mit_KHE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28062">
        <property type="entry name" value="K+-H+ EXCHANGE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28062:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10173">
        <property type="entry name" value="Mit_KHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="34992" checksum="3A485640618BDB6D" modified="2011-10-19" version="1">MRLYLLPISTRRTLLYCQRLNTPAAAESQTTWADKIQAKAARTWSGWEKRDRGWQKAVVSYGNYLLRRIPYEEWGLKSVPPLSQRRREVELDGSEKVEVIYPQSLLSRERIPRIIGQLATEREALHKARLIWCLVGVPITIPIGLIPLVPNLPFFYLAYRAWSHWRALSGGKHLQFLVNNNLLHLSPSPVVDEVYANRPQESNPTPLASSPEPTTSSPSSMEPVIEPSSYEKGPQIGAREVGQAETMLLTQEKGKKMTQALDLPQLEVELERAIWQVETAIRKRSAEVAGAAAAAENVRRAEVLDEKKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4N6</accession>
    <name>G0S4N6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0031660</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693607.1">
        <property type="nucleotide sequence ID" value="XM_006693544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4N6"/>
    <dbReference type="GeneID" id="18257204"/>
    <dbReference type="KEGG" id="cthr:CTHT_0031660"/>
    <dbReference type="eggNOG" id="ENOG502QS4K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036005_1_0_1"/>
    <dbReference type="OMA" id="ARGHPEN"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000005">
        <property type="entry name" value="TfdA family taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF10">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="34"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS21311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="365" mass="41123" checksum="174842BC5441EBDF" modified="2011-10-19" version="1">MAPSAIEADDSVNTKGPIREPLKLSGALNGYEYFDVTPVIGREYPTANLVEWLNSPNSDDLLRDLAITISQRGVVFFRAQDNLTNELQKKLILRLGELTGRPETSGLHIHPILNSERELGGDDLEISTISSVQNKKFYSTATRDATLNPKKQSTAQWHSDIAFEPVPADYTSLRLVQLPTTGGDTLWASGYELYDRLSEPYQRFLETLTATFEQPVFRDIAERSGFQLYDKPRGAPENVGSELKAVHPVVRTNPVTGWKSIFPVGGHVKHINGLTEEESRRLLDWFLELVYKNHDLQVRFKWQNKNDIADKLAAIWDNRSVFHTATFDYLDGSYGERFGNRVVGLGEKPYLDPNSTSRRAALAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4T6</accession>
    <name>G0S4T6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0023470</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692811.1">
        <property type="nucleotide sequence ID" value="XM_006692748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4T6"/>
    <dbReference type="GeneID" id="18256385"/>
    <dbReference type="KEGG" id="cthr:CTHT_0023470"/>
    <dbReference type="eggNOG" id="ENOG502S1YP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014331_1_0_1"/>
    <dbReference type="OMA" id="IGWAFNC"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="409" mass="46958" checksum="37F1DAD7A64179CD" modified="2011-10-19" version="1">MNDDDSDHITGGFVESQLLWKNATDFWAVFGWACRCAAEHPQRWQYWRVWLDFVIEAMERDWDERLSKDIASGKTSKGKSAPAYPLLRESLLVTFLADLERQRKNIEREVLRALFAFCNDNSATHLYYKEVFKKETATIKSQNKRKRADAVVDLENDRFGDYFDDYDYDDYDDDDVDADGQDEISASASRPKKKGRKHKSETAISSFNLTDTVAESIPLRLRIFRLLSAAAYYISDVFMPVDELYEKFTDELRKLPLPVFRLFIQSHTSILPRMVQVTLLRVVANNLLPHNKPDPAEVDPNHGSCSDLTQLIMTECYLPFAAKFTNTEDNAKLSMTLESLMWYLFDQIEIQYSDELCNAVETGIRAREGRIPRRAGRMSAADKQAREALARSAENLRALLDVLAAAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4V0</accession>
    <name>G0S4V0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4419 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0031760</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693617.1">
        <property type="nucleotide sequence ID" value="XM_006693554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4V0"/>
    <dbReference type="GeneID" id="18257214"/>
    <dbReference type="KEGG" id="cthr:CTHT_0031760"/>
    <dbReference type="eggNOG" id="ENOG502RPX4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037155_1_0_1"/>
    <dbReference type="OMA" id="MGLMQHY"/>
    <dbReference type="OrthoDB" id="9978173at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025533">
        <property type="entry name" value="DUF4419"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31252">
        <property type="entry name" value="DUF4419 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31252:SF11">
        <property type="entry name" value="DUF4419 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14388">
        <property type="entry name" value="DUF4419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS21321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="38365" checksum="B10765BF7DF7496E" modified="2011-10-19" version="1">MLSSYSGTLRPETANASEIFPSSDSFIRGAIQAWGEHLHLEIRPDEVWFTILTQLNFYMERNAEAVRHLFVKHQGQETIFIEDTTWTKVLWRFKDEIQARILTPWLKDWIVPDFSTTTDNDIMTANILMMGFMKAYFRYEGGIICGLPSVTLLGKKEDWEKLLSRLDRLSEFGKEPDEYRARLTPLLKRFVRSFDIPDSPEIRKFWNQIVFAKHEAICGGSPLDLSGWITGFIYWKNDGTRWGDNRKGGIIIDGISYGGYHDILTLPSGYARAPFIMRDFMGRDRYPAYVAAGTLGKRLIKGAPHGYIDALVRSGQNVSKADLEPDLHGTLRPLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4X3</accession>
    <name>G0S4X3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase III subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0031990</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPC7 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693640.1">
        <property type="nucleotide sequence ID" value="XM_006693577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4X3"/>
    <dbReference type="STRING" id="759272.G0S4X3"/>
    <dbReference type="GeneID" id="18257237"/>
    <dbReference type="KEGG" id="cthr:CTHT_0031990"/>
    <dbReference type="eggNOG" id="ENOG502RZ0V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072641_1_0_1"/>
    <dbReference type="OMA" id="EWSSRPV"/>
    <dbReference type="OrthoDB" id="5377312at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024661">
        <property type="entry name" value="RNA_pol_III_Rpc31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11705">
        <property type="entry name" value="RNA_pol_3_Rpc31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="124"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="192"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="197"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS21344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="28991" checksum="A47133CDAFB56EF9" modified="2011-10-19" version="1">MSGRGGRGGRGGRGGRGGPMMNGRRSVAQNSVPWTMDSDIVLDGKPSEQFPCQDSPLYTQARSYNDSGPRRVYGQEQINKRYGTVSRATIDPFTAVPQYSDRFQKVPRTLPDLGSRPFAKEFFPPELHATLDGEDDGAPASKKRRTGPKTLGLSNITSYRTAEEVFMLEAQTGVAGGGASLDKALQLLNTLEKRGDEGEEEFLSGEDDDDWVKNNGDDEEEGDAEEDDQYEDESGDDYNAEQYFDGNQDDDDYDDGGDDGGDYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5Q8</accession>
    <name>G0S5Q8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dihydrofolate reductase</fullName>
            <ecNumber evidence="2">1.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0025130</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the dihydrofolate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="2"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692973.1">
        <property type="nucleotide sequence ID" value="XM_006692910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5Q8"/>
    <dbReference type="STRING" id="759272.G0S5Q8"/>
    <dbReference type="GeneID" id="18256551"/>
    <dbReference type="KEGG" id="cthr:CTHT_0025130"/>
    <dbReference type="eggNOG" id="KOG1324">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043966_2_1_1"/>
    <dbReference type="OMA" id="QYEFQMW"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046452">
        <property type="term" value="P:dihydrofolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046655">
        <property type="term" value="P:folic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00209">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012259">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017925">
        <property type="entry name" value="DHFR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069:SF3">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00186">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00070">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00075">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51330">
        <property type="entry name" value="DHFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHFR" evidence="8">
        <location>
            <begin position="5"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS20677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="234" mass="26181" checksum="63F9C3ABEA9158FC" modified="2011-10-19" version="1">MPSLDLTLIVAAAARDMGIGRNGTLPWKGLKKEMAYFARVTKRPPPSALSASSEEKQQTRKLQNAVIMGRKTWESIPPKFRPLPGRLNVVISRTVGDEVVKGGVADEVKRADVLTARSLEEALALLQKRHQDEKGDGDVGRVFVIGGAQIYDAALALPETRRIVLTRVRKEEGEFECDAFFPVRLDAQENGGSREWRRVSQEEMDAWVGEEVPRGVQREAGAEYEFEMWERMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5X1</accession>
    <name>G0S5X1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0025230</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692983.1">
        <property type="nucleotide sequence ID" value="XM_006692920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5X1"/>
    <dbReference type="STRING" id="759272.G0S5X1"/>
    <dbReference type="GeneID" id="18256561"/>
    <dbReference type="KEGG" id="cthr:CTHT_0025230"/>
    <dbReference type="eggNOG" id="ENOG502QVCT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005319_0_0_1"/>
    <dbReference type="OMA" id="SYEDSGR"/>
    <dbReference type="OrthoDB" id="3938623at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045142">
        <property type="entry name" value="BCAS3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13268:SF0">
        <property type="entry name" value="BCAS3 MICROTUBULE ASSOCIATED CELL MIGRATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13268">
        <property type="entry name" value="BREAST CARCINOMA AMPLIFIED SEQUENCE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1036"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1057"/>
            <end position="1066"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1193" mass="126463" checksum="6253289498DB0442" modified="2011-10-19" version="1">MMDAMCEANWRFATVTGHKKDRKNGKEGGSVVAAVTKHGAKFSNGTVSKATSSEPSPIVSPEIQPASSLSSTDHPVTSPLLDAASGTGTSYTTSTSPGAQDWPRGLSPGMAGSPGNLINFVGESPPTAPSSYEDARGAPGRAGPTLPRPIAAHHTPASASPPIVGRRPFSLHMDSHYSPPDTHLPLSAAAVARRGSLNSPYVHGRIVSNPPLPHHPQAHFYGAAPLDLDPTPRSGMKAGEKGYYFGFDVLTLPSVDRAPGKDTVVLAGYEGGLEVFSVSRRGVEHVANLKGLRGGVYHAKVLPWTSASSDLFPLVAVVVHGPILPQRTSEGGVEGGDYDPVSADRSDAMINSPAPSVKNAGSSKTGAGLIEAYQTSVEVWSLKTGQQFCVLLEAPKIPLKTSITSPSFHAPPPTGAFHIHADGGNIIVSSGVTGECWVYRQMPPVGELPLHFGCIGKLWTTLQQPPKGDTPQEPDWSRIPGPSSPRPRPQTAIVSVSGRWIAYCPAAPSSQISLRASVPVPVYGRAPGLTSMTAPQLPPVNAEVDLFMTESVVNKVMRDATQEIIQGARWIGKQGMQAWNNYWNPQPNQQPRSPTTAPQGWGETLQFPPTHGPVTSQPVVKDPGMVSIIDIETLGSFSNLHPIATFSVPNGCSFLSLSPSGLSLFSASSKGDVQTVWDLMRIHNTRSSPLQAAASPLGGPRVRQVAHFSRMTVARIIDVAWTRPNGERIAMVTERGTVHILDLPPSAFSWPPPRRRRAQETKAAAAASEAPTSVASSAASSAVSIASSALSSVRDVALPLINRHQRSSSSTQAATGSAIGGYAAAGGKVLAASITHSLGKTGNVISQLRHTGENRVSLPSSSPPGPSCVIWVPGKRNHSLFILGMGLVRTFPCRTRKADGKGGKGHKTLRLSRYKDHSLPMLPDDVLPPVVKRILDPEEYLDLAAAAADRDFEAGANTLVLNQPRPRVQKPYDLSAESAIPQAEIESSAPYQPFHTDRRVVLYELTPSRPTNTGNELQERDLSSLMSGASLGDNTPLSSSPEPSSTPSRRGKKRQPPALPSPLPPPPAVVPAASSVIITSSLPSGAWVFGQPLPAIRLDVGTGHHHLLDDADDDSDNPTVFSIPLDSHASRALPAEAMERVLMHTDGGDTNVGMAQIVITTRKRRNRYRGGEGDEDGFFEDDCEVLDFADQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6D7</accession>
    <name>G0S6D7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0034550</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693888.1">
        <property type="nucleotide sequence ID" value="XM_006693825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6D7"/>
    <dbReference type="STRING" id="759272.G0S6D7"/>
    <dbReference type="GeneID" id="18257493"/>
    <dbReference type="KEGG" id="cthr:CTHT_0034550"/>
    <dbReference type="eggNOG" id="KOG1036">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038526_0_0_1"/>
    <dbReference type="OMA" id="WDSTLHI"/>
    <dbReference type="OrthoDB" id="10262475at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000725">
        <property type="entry name" value="Nuclear pore complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="96"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="257"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS21592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="350" mass="38091" checksum="C08D393C14664512" modified="2011-10-19" version="1">MAPATQFEVAQPPNDAISAIDFAPEAPRFLVSSWDKNVYLYEIASGSEQATLINAFEHRAPVLSVCFGANQDEAFTAGMDRQVKKLNLVTGEQTVLSKHSEPVRCVVYSSEHSLLISASWDSTLHVHNAANLSQPHITIPLPGKPHALAASRTKLVVAMTARLVHIYDLPTLLSAVRSNTQTPPQPWQQRESSLKFLTRAVACMPNDAGYATSSIEGRVAVEWFDDSAESQARKYAFKCHRQAAPEAEGGGDIVYPVNALAFHPIYGTFASGGGDGTVALWDAEAKRRMRQYQRFPDSVAALAFSRDGRYLAIGVCPGFETGMEDYSGEGRTKVFVRELGETEAKGKGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6G2</accession>
    <name>G0S6G2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA ligase</fullName>
            <ecNumber evidence="1">6.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0034810</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2019" name="Elife" volume="8" first="e44199" last="e44199">
            <title>tRNA ligase structure reveals kinetic competition between non-conventional mRNA splicing and mRNA decay.</title>
            <authorList>
                <person name="Peschek J."/>
                <person name="Walter P."/>
            </authorList>
            <dbReference type="PubMed" id="31237564"/>
            <dbReference type="DOI" id="10.7554/elife.44199"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 2-414</scope>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2019" name="Nucleic Acids Res." volume="47" first="1428" last="1439">
            <title>Structure and two-metal mechanism of fungal tRNA ligase.</title>
            <authorList>
                <person name="Banerjee A."/>
                <person name="Ghosh S."/>
                <person name="Goldgur Y."/>
                <person name="Shuman S."/>
            </authorList>
            <dbReference type="PubMed" id="30590734"/>
            <dbReference type="DOI" id="10.1093/nar/gky1275"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 1-407 IN COMPLEX WITH ATP AND MN(2+)</scope>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2025" name="Nat. Struct. Mol. Biol." volume="0" first="0" last="0">
            <title>Structure of fungal tRNA ligase Trl1 with RNA reveals conserved substrate-binding principles.</title>
            <authorList>
                <person name="Kohler S."/>
                <person name="Kopp J."/>
                <person name="Maiti S."/>
                <person name="Bujnicki J.M."/>
                <person name="Peschek J."/>
            </authorList>
            <dbReference type="PubMed" id="40563009"/>
            <dbReference type="DOI" id="10.1038/s41594-025-01589-3"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.37 ANGSTROMS) OF 1-414 IN COMPLEX WITH AMP</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + (ribonucleotide)n-3'-hydroxyl + 5'-phospho-(ribonucleotide)m = (ribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRL1 family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.3" evidence="1"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693913.1">
        <property type="nucleotide sequence ID" value="XM_006693850.1"/>
    </dbReference>
    <dbReference type="PDB" id="6N0T">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.51 A"/>
        <property type="chains" value="A=1-407"/>
    </dbReference>
    <dbReference type="PDB" id="6N0V">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.50 A"/>
        <property type="chains" value="A/B=1-407"/>
    </dbReference>
    <dbReference type="PDB" id="6N67">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.90 A"/>
        <property type="chains" value="A=2-414"/>
    </dbReference>
    <dbReference type="PDB" id="8RBJ">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.37 A"/>
        <property type="chains" value="A=1-414"/>
    </dbReference>
    <dbReference type="PDBsum" id="6N0T"/>
    <dbReference type="PDBsum" id="6N0V"/>
    <dbReference type="PDBsum" id="6N67"/>
    <dbReference type="AlphaFoldDB" id="G0S6G2"/>
    <dbReference type="SMR" id="G0S6G2"/>
    <dbReference type="STRING" id="759272.G0S6G2"/>
    <dbReference type="GeneID" id="18257519"/>
    <dbReference type="KEGG" id="cthr:CTHT_0034810"/>
    <dbReference type="eggNOG" id="ENOG502QQB9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010316_1_0_1"/>
    <dbReference type="OMA" id="FQDWDYK"/>
    <dbReference type="OrthoDB" id="276239at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051730">
        <property type="term" value="F:GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003972">
        <property type="term" value="F:RNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001690">
        <property type="entry name" value="tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019039">
        <property type="entry name" value="T4-Rnl1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012387">
        <property type="entry name" value="Trl1_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015966">
        <property type="entry name" value="tRNA_lig_kin_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015965">
        <property type="entry name" value="tRNA_lig_PDEase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32004">
        <property type="entry name" value="TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32004:SF1">
        <property type="entry name" value="TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09511">
        <property type="entry name" value="RNA_lig_T4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08302">
        <property type="entry name" value="tRNA_lig_CPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08303">
        <property type="entry name" value="tRNA_lig_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019634">
        <property type="entry name" value="tRNA_lig_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9 10 11" id="KW-0002">3D-structure</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="T4 RNA ligase 1-like N-terminal" evidence="6">
        <location>
            <begin position="97"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA ligase kinase" evidence="5">
        <location>
            <begin position="419"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA ligase phosphodiesterase" evidence="4">
        <location>
            <begin position="577"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="621"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="621"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="641"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="2">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR019634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR019634-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS21617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="6N0T"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="6N0V"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="6N67"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="8RBJ"/>
        </source>
    </evidence>
    <sequence length="846" mass="95394" checksum="997C393E6E0DEB32" modified="2011-10-19" version="1">MDGTAEKQRDSLASRYKASTDYAKDAEGLTAPYVSQDPQETAALVRALDDAAKKGKKSGGFSVKKTRYAVASSPTGAEVDSWRFNDWDYKKPDLPTYARGLFTTRTQHGVPEIAVRGYDKFFNIDETRDTAWSAIRERTKGPYELTLKENGCIIFISGLEDGTLLVCSKHSTGDRSDVALSHSSAGEKHLEAQLERIGKTKEELARELRKRNATAVAELCDDSFEEHILAYGPDKAGLYLHGINLNIPEFITYPSPLVQKFAEDWGFRKTGLIIIDNIDDVKAFLEEVAETGAHDGRDVEGFVIRCKKSTNPGVGPYHDWFFKYKFEEPYLMYRQWRECTKALISGKQPKIKKHVKITEEYLLYARKRLAADPKLAKLYNQNHGIIKLRNDFLEYKNMKGTDAANLEDDGAASVTRDIILVPIATIGCGKTTLGVALTKLFGWGHIQNDNITGSKRPPRFTKAVLDELNEHPAVFADRNNSMRQERKQLLTDVKMQHTTARLVALHFVHDDINTVRKVTQERVIQRGDNHQTIQAATDVNKVIGIMEGFIHRFEPCDPEKDPDEGFDAVIDLDPTAGSRENLEVVIRELHRLYPNFVKEVPPAEAMDEAIKFAMESYKPDLRHIIPDRSKNKDKKKEGKQEQQQQPAAQKPPKKKPLEYMSVDMPTKGVLDALEKTFGSVPVEQARFFKQLQGTRRVQAKFHVTLMHRATAKEHPELWQRYTKLHGEATAENPDAQLGELDVQLERVVWDSRIMAIVVRLIPVNPEDAEVKDPAKPDQPGQPKWQCVNRVAHITVGTRDDSVKPKESNDLLCRWLEVGSGGETGIGELIMQGKPILRGIVKGVLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6H0</accession>
    <name>G0S6H0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fructose-bisphosphate aldolase</fullName>
            <shortName evidence="3">FBP aldolase</shortName>
            <ecNumber evidence="3">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0034890</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2 3">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="3"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693921.1">
        <property type="nucleotide sequence ID" value="XM_006693858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6H0"/>
    <dbReference type="STRING" id="759272.G0S6H0"/>
    <dbReference type="GeneID" id="18257527"/>
    <dbReference type="KEGG" id="cthr:CTHT_0034890"/>
    <dbReference type="eggNOG" id="KOG0409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040088_4_0_1"/>
    <dbReference type="OMA" id="TCYSAIR"/>
    <dbReference type="OrthoDB" id="2558351at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00947">
        <property type="entry name" value="TBP_aldolase_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050246">
        <property type="entry name" value="Class_II_FBP_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30304">
        <property type="entry name" value="D-TAGATOSE-1,6-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30304:SF0">
        <property type="entry name" value="D-TAGATOSE-1,6-BISPHOSPHATE ALDOLASE SUBUNIT GATY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS21625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="288" mass="31743" checksum="73305E4646652B40" modified="2011-10-19" version="1">MPRSKLHGNRTMDILNKAKEGGYAVPAICCYNIEGIIATVKAAEALRSPAIILLFPWAIQYAGEALVRAAATAAHSASVPISLHLDHCQTPEMVRRAADIPDGFDSIMCDMSHYDREENLRLTAELVQYCHKRGIATEAEPGRIEGGEDGVPETADLEGFLTTPEEAEEFVKTGIDMLAPAFGNVHGSYGQRGIRLEYDRLKAIHEKVGDKVQLVLHGCDPFDEKTFRECMVRGVTKININKGMNNHYARVQGEMREKPLTSVIEAGTKAMQEAVEQYMHWFGSAGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6I7</accession>
    <name>G0S6I7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0026360</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="476" last="476">
            <title>High-resolution structures of a thermophilic eukaryotic 80S ribosome reveal atomistic details of translocation.</title>
            <authorList>
                <person name="Kisonaite M."/>
                <person name="Wild K."/>
                <person name="Lapouge K."/>
                <person name="Ruppert T."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="35079002"/>
            <dbReference type="DOI" id="10.1038/s41467-022-27967-9"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.90 ANGSTROMS)</scope>
    </reference>
    <reference evidence="14 15" key="3">
        <citation type="journal article" date="2023" name="Nat. Struct. Mol. Biol." volume="30" first="670" last="677">
            <title>Structural inventory of cotranslational protein folding by the eukaryotic RAC complex.</title>
            <authorList>
                <person name="Kisonaite M."/>
                <person name="Wild K."/>
                <person name="Lapouge K."/>
                <person name="Gese G.V."/>
                <person name="Kellner N."/>
                <person name="Hurt E."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="37081320"/>
            <dbReference type="DOI" id="10.1038/s41594-023-00973-1"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.20 ANGSTROMS)</scope>
    </reference>
    <reference evidence="16" key="4">
        <citation type="journal article" date="2024" name="Nat. Commun." volume="15" first="716" last="716">
            <title>Methionine aminopeptidase 2 and its autoproteolysis product have different binding sites on the ribosome.</title>
            <authorList>
                <person name="Klein M.A."/>
                <person name="Wild K."/>
                <person name="Kisonaite M."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="38267453"/>
            <dbReference type="DOI" id="10.1038/s41467-024-44862-7"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.10 ANGSTROMS)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693094.1">
        <property type="nucleotide sequence ID" value="XM_006693031.1"/>
    </dbReference>
    <dbReference type="PDB" id="7OLC">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="SD=1-254"/>
    </dbReference>
    <dbReference type="PDB" id="7OLD">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="SD=1-254"/>
    </dbReference>
    <dbReference type="PDB" id="7Z3N">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="SD=1-254"/>
    </dbReference>
    <dbReference type="PDB" id="7Z3O">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.30 A"/>
        <property type="chains" value="SD=1-254"/>
    </dbReference>
    <dbReference type="PDB" id="8OO0">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="SD=1-254"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6I7"/>
    <dbReference type="EMDB" id="EMD-12976"/>
    <dbReference type="EMDB" id="EMD-12977"/>
    <dbReference type="EMDB" id="EMD-14479"/>
    <dbReference type="EMDB" id="EMD-14480"/>
    <dbReference type="EMDB" id="EMD-17004"/>
    <dbReference type="STRING" id="759272.G0S6I7"/>
    <dbReference type="GeneID" id="18256674"/>
    <dbReference type="KEGG" id="cthr:CTHT_0026360"/>
    <dbReference type="eggNOG" id="KOG3181">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058591_2_0_1"/>
    <dbReference type="OMA" id="NKKKWMI"/>
    <dbReference type="OrthoDB" id="10248446at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02413">
        <property type="entry name" value="KH-II_40S_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1140.32:FF:000004">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.20:FF:000006">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="entry name" value="Ribosomal protein S3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057258">
        <property type="entry name" value="Ribosomal_uS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_uS3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_uS3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005703">
        <property type="entry name" value="Ribosomal_uS3_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003219">
        <property type="entry name" value="PRK04191.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01008">
        <property type="entry name" value="uS3_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760:SF32">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="Ribosomal protein S3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="12 13 14" id="KW-0002">3D-structure</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="9">
        <location>
            <begin position="24"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="218"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS20798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="7OLC"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="7OLD"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="7Z3N"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="7Z3O"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="8OO0"/>
        </source>
    </evidence>
    <sequence length="254" mass="27854" checksum="88C76DDD5CA34E86" modified="2011-10-19" version="1">MAVPGTQISKKRKFVADGVFYAELNEFFQRELAEEGYSGVEVRVTPTVTDIIIRATHTQEVLGEQGRRIRELTSLIQKRFKFPENSVSLYAAKVQNRGLSAVAQCESLRYKLLNGLAVRRACYGVLRFIMESGAKGCEVVVSGKLRAARAKSMKFTDGFMIHSGQPAREFIDTATRHVLLRQGVLGIKVKIMRGSDPDGKSGPQKTLPDVVTVIEPKEETPVVQPMSQDYGAKAAAAAAAQEEPVEEEAAPAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6K8</accession>
    <name>G0S6K8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative vacuolar-protein sorting-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0026570</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693115.1">
        <property type="nucleotide sequence ID" value="XM_006693052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6K8"/>
    <dbReference type="STRING" id="759272.G0S6K8"/>
    <dbReference type="GeneID" id="18256695"/>
    <dbReference type="KEGG" id="cthr:CTHT_0026570"/>
    <dbReference type="eggNOG" id="KOG3230">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069208_1_0_1"/>
    <dbReference type="OMA" id="KMAKMNQ"/>
    <dbReference type="OrthoDB" id="10252926at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS20819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="224" mass="25480" checksum="40FEC2667D5B3C9C" modified="2011-10-19" version="1">MNVLEWAFGKRVTPAERLRKNQRLLDKAIRELDQQRMKLERQEKTLITQIRQSAQKGQMGACKIQAKDLVRTRRYIEKFYAMRSQLQKISLRLQTYRTNEQMMQAMKGATMALGSMNRTMNLPSLQRIAMEFERENDIMEQRQEMMDDAIDDAMDVGLEEEGDEVVEQVLEEIGVDLKQALGEAPSGLQSSSVSEPKIAQAIGGGGSGDPGDDDLQARLDSLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7A2</accession>
    <name>G0S7A2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">T-complex protein 1 subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0036130</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694042.1">
        <property type="nucleotide sequence ID" value="XM_006693979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7A2"/>
    <dbReference type="STRING" id="759272.G0S7A2"/>
    <dbReference type="GeneID" id="18257651"/>
    <dbReference type="KEGG" id="cthr:CTHT_0036130"/>
    <dbReference type="eggNOG" id="KOG0360">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_5_1_1"/>
    <dbReference type="OMA" id="RGPNDYQ"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03335">
        <property type="entry name" value="TCP1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000005">
        <property type="entry name" value="T-complex protein 1 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000009">
        <property type="entry name" value="T-complex protein 1 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000070">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012715">
        <property type="entry name" value="Chap_CCT_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02340">
        <property type="entry name" value="chap_CCT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS21746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="566" mass="61448" checksum="6F6BC00CA29308EE" modified="2011-10-19" version="1">MAAIFEQPRNGTLFLGGQKISGADIRDQNVLATQAIANVVKSSFGPSGLDKMMVDDIGDVTVTNDGATILSLLDVEHPAGKILVDLAQQQDKEVGDGTTSVVLIAAELLKRANDLMKNRIHPTTIITGYRLALREAVKYMNEHVSIKVENLGRESLLNIAKTSMSSKIIGADADFFANMVVDAIQAVKTTNNKNEVKYPVKAVNILKAHGKSATESMLIKGYALNCTVASQAMKTRITDAKIACLDMNLQKERMKLGVQITIDDPEQLEAIRAREATMVLERIDMILKAGANVILTTKGIDDLCLKAFVEKGAMAVRRCKKEDLRRIAKATGATLLATFSDLNGDEKFEPSYLGHAEEVVQERIADDECILIKGTKAHSSASIILRGPNEFTLDEMERSVHDSLCAVKRTLESGSIVPGGGAVETALHIFLEEFAGTVGSREQLAIGEFAQSLLVIPKTLAINAAKDASELVAQLRSRHALSQRIQEGEGSEDEKTIAKKKAYKNYGLDLVRGKVVDEIKAGVVEPSISKIRQLKSATEACIAIMRIDTLIKLDPEPQPEDDGHDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7E0</accession>
    <name>G0S7E0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="20 21">Cytochrome b-c1 complex subunit Rieske, mitochondrial</fullName>
            <ecNumber evidence="3 21">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">CTHT_0036520</name>
    </gene>
    <organism evidence="25">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19 21">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="21">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="21">The Rieske protein is a high potential 2Fe-2S protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rieske iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="3 21"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694080.1">
        <property type="nucleotide sequence ID" value="XM_006694017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7E0"/>
    <dbReference type="STRING" id="759272.G0S7E0"/>
    <dbReference type="GeneID" id="18257690"/>
    <dbReference type="KEGG" id="cthr:CTHT_0036520"/>
    <dbReference type="eggNOG" id="KOG1671">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055690_0_0_1"/>
    <dbReference type="OMA" id="PPYDFND"/>
    <dbReference type="OrthoDB" id="1637982at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03470">
        <property type="entry name" value="Rieske_cytochrome_bc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.270:FF:000002">
        <property type="entry name" value="Cytochrome b-c1 complex subunit Rieske, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.10.10:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit Rieske, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.270">
        <property type="entry name" value="Ubiquinol cytochrome reductase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037008">
        <property type="entry name" value="bc1_Rieske_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004192">
        <property type="entry name" value="Rieske_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006317">
        <property type="entry name" value="Ubiquinol_cyt_c_Rdtase_Fe-S-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01416">
        <property type="entry name" value="Rieske_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02921">
        <property type="entry name" value="UCR_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81502">
        <property type="entry name" value="ISP transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12 21" id="KW-0249">Electron transport</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16 22" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 22" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 21" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rieske" evidence="23">
        <location>
            <begin position="138"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00072517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU004494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU004495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EGS21784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="235" mass="25120" checksum="9A02FBAE0759C372" modified="2011-10-19" version="1">MAPVSTVSRALARSAAFRLPTNAVRAMSTTPAVCGSAASSTFQSPFKGESKTTRIPDFSKYKTSGSSTQNALISYFMVGTLGAISAAGAKSTVQEFLVNMSASADVLAMAKVEVDLAAIPEGKNVIIKWRGKPVFIRHRTQAEIDEANSVNVASLRHPETDDQRVKKPEWLVMLGVCTHLGCVPIGEAGDFGGWFCPCHGSHYDISGRIRKGPAPLNLEIPEYDFSEDGTKLIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7F1</accession>
    <name>G0S7F1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0027920</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693249.1">
        <property type="nucleotide sequence ID" value="XM_006693186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7F1"/>
    <dbReference type="STRING" id="759272.G0S7F1"/>
    <dbReference type="GeneID" id="18256830"/>
    <dbReference type="KEGG" id="cthr:CTHT_0027920"/>
    <dbReference type="eggNOG" id="KOG0880">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_4_1_1"/>
    <dbReference type="OMA" id="ENHEITH"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000001">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006524785" description="Peptidyl-prolyl cis-trans isomerase" evidence="4">
        <location>
            <begin position="28"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="38"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS20953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="207" mass="22643" checksum="281EBC7570E15EF5" modified="2011-10-19" version="1">MFNLKKLFLAATALVGAGLFIAQPVEAVKGPKITHKVYFDIEHGGEPLGRIVLGLYGKTVPKTAENFRALATGEKGFGYEGSTFHRVIKNFMIQGGDFTNHDGTGGKSIYGDRFPDENFKLKHNRKGLLSMANAGKDTNGSQFFITTVVTSWLDGRHVVFGEVLEGYDVVEKIENVPTQANDRPVKEVKIVKSGELPVPPEGIHVEL</sequence>
</entry>
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            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
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                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
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        <property type="entry name" value="MID1/Yam8"/>
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        </source>
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    <accession>G0S7Q4</accession>
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            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
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                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
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        </source>
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        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="294" mass="31409" checksum="3D24B21077A97D5F" modified="2011-10-19" version="1">MMHEVENVPDGPERPSFVQPSEMPGAHDGQSDHADDVNWETENGLDGRGDRRHYGNGRGADGNGVSSAESAEMARQAGRSEPEQLRLPLQPSMLEEGGSTASGGDACGLDRGRGHVPCPGHVPDPCLDPGLCRGLCRGLCLYLDLDLARAHVLVLVPGLEPARGRGRDHALVHDLCLDRGPGPDLALSLCPCPGLAPCLCLYLSPGRGPFRGLSHGPFPCLCPGLCLYFYLCHGPGHDLCPCLVLCLYLDLVLALCLAHGQPCLAHDLDLALGGRREIDSRQQQEQQARGIYVK</sequence>
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    <accession>G0S7X0</accession>
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        <name evidence="2" type="ORF">CTHT_0037280</name>
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    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
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                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
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            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Cell" volume="166" first="380" last="393">
            <title>Architecture of the 90S Pre-ribosome: A Structural View on the Birth of the Eukaryotic Ribosome.</title>
            <authorList>
                <person name="Kornprobst M."/>
                <person name="Turk M."/>
                <person name="Kellner N."/>
                <person name="Cheng J."/>
                <person name="Flemming D."/>
                <person name="Kos-Braun I."/>
                <person name="Kos M."/>
                <person name="Thoms M."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="27419870"/>
            <dbReference type="DOI" id="10.1016/j.cell.2016.06.014"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (7.30 ANGSTROMS)</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2017" name="Nat. Struct. Mol. Biol." volume="24" first="954" last="964">
            <title>3.2-A-resolution structure of the 90S preribosome before A1 pre-rRNA cleavage.</title>
            <authorList>
                <person name="Cheng J."/>
                <person name="Kellner N."/>
                <person name="Berninghausen O."/>
                <person name="Hurt E."/>
                <person name="Beckmann R."/>
            </authorList>
            <dbReference type="PubMed" id="28967883"/>
            <dbReference type="DOI" id="10.1038/nsmb.3476"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.20 ANGSTROMS)</scope>
    </reference>
    <reference evidence="6 7 8" key="4">
        <citation type="journal article" date="2019" name="Mol. Cell" volume="75" first="1256" last="1269.e7">
            <title>Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration.</title>
            <authorList>
                <person name="Cheng J."/>
                <person name="Bassler J."/>
                <person name="Fischer P."/>
                <person name="Lau B."/>
                <person name="Kellner N."/>
                <person name="Kunze R."/>
                <person name="Griesel S."/>
                <person name="Kallas M."/>
                <person name="Berninghausen O."/>
                <person name="Strauss D."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="31378463"/>
            <dbReference type="DOI" id="10.1016/j.molcel.2019.06.032"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.50 ANGSTROMS)</scope>
    </reference>
    <reference evidence="9 10 11" key="5">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e56910" last="e56910">
            <title>Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation during pre-60S biogenesis.</title>
            <authorList>
                <person name="Lau B."/>
                <person name="Huang Z."/>
                <person name="Kellner N."/>
                <person name="Niu S."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
                <person name="Cheng J."/>
            </authorList>
            <dbReference type="PubMed" id="37129998"/>
            <dbReference type="DOI" id="10.15252/embr.202356910"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <reference evidence="12 13 14" key="6">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e57984" last="e57984">
            <title>Structural insights into coordinating 5S RNP rotation with ITS2 pre-RNA processing during ribosome formation.</title>
            <authorList>
                <person name="Thoms M."/>
                <person name="Lau B."/>
                <person name="Cheng J."/>
                <person name="Fromm L."/>
                <person name="Denk T."/>
                <person name="Kellner N."/>
                <person name="Flemming D."/>
                <person name="Fischer P."/>
                <person name="Falquet L."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="37921038"/>
            <dbReference type="DOI" id="10.15252/embr.202357984"/>
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        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.12 ANGSTROMS)</scope>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21857.1"/>
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    <dbReference type="EMDB" id="EMD-35290"/>
    <dbReference type="EMDB" id="EMD-3847"/>
    <dbReference type="SMR" id="G0S7X0"/>
    <dbReference type="IntAct" id="G0S7X0">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S7X0"/>
    <dbReference type="GeneID" id="18257766"/>
    <dbReference type="KEGG" id="cthr:CTHT_0037280"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026457_5_0_1"/>
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    <dbReference type="OrthoDB" id="10251727at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4 5 6" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="5JPQ"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="5OQL"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="6RXT"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="6RXU"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="6RXV"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="8I9P"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="8I9R"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="8I9T"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="8PV1"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="8PV3"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="8PV4"/>
        </source>
    </evidence>
    <sequence length="391" mass="43619" checksum="D1DB36612CB62DD7" modified="2011-10-19" version="1">MAPSTAVAKKETDAVIPVDPDQTLKACKALLAHIKKAAAAPRPDGKQNLLADEESTVAETPIWLTLTTKKHIHDSHRLQPGKIILPHPLNTSEEISVCLITADPQRFYKNAVADEFPEDLRAKIGRVIDISHLKAKFKAYEAQRKLFSEHDVFLADTRIINRLPKALGKTFYKTTTKRPIPVVLMAQREKVNGKRVPAPKGKKEKRDPLENANARPIPEIVAEIRKAIGAALVHLSPSTNTAIKVGYANWEPEKLAANIETVIRELVERFVPQKWQNVRNFYVKGPETAALPIYQTDELWLDESKVVPDGQEPARALPGKREKANIGKKRKPLEDASQPALEETGKDERPKKKAKKTLPESNDDKLDKAIAERKEQLKKQKAAAKKVAADI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7Z6</accession>
    <name>G0S7Z6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0037560</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694179.1">
        <property type="nucleotide sequence ID" value="XM_006694116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7Z6"/>
    <dbReference type="STRING" id="759272.G0S7Z6"/>
    <dbReference type="GeneID" id="18257794"/>
    <dbReference type="KEGG" id="cthr:CTHT_0037560"/>
    <dbReference type="eggNOG" id="ENOG502SUBI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085820_0_0_1"/>
    <dbReference type="OMA" id="APSHHYH"/>
    <dbReference type="OrthoDB" id="4207123at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42095">
        <property type="entry name" value="YALI0C12166P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42095:SF1">
        <property type="entry name" value="YALI0C12166P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="180" mass="18750" checksum="3AB2216F53279F2E" modified="2011-10-19" version="1">MSSQRPFFLSTFFAAFRQQGSSLSSASAASASSNKHTSQPSSSSNPTQNTSSAPRTIHSSTTAAAAAAAAVQASSSSPSSTVLSQLPLHSPRHHSHHHHSTGIPIPQQSSSNSGSSSPVGGSHSRRRGSDSSSEGFREALGAEKLYIGGRTATGEERFFKLGVVRRVRSGDMLSLDRLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G0S833</accession>
    <name>G0S833_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0029210</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693376.1">
        <property type="nucleotide sequence ID" value="XM_006693313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S833"/>
    <dbReference type="STRING" id="759272.G0S833"/>
    <dbReference type="GeneID" id="18256959"/>
    <dbReference type="KEGG" id="cthr:CTHT_0029210"/>
    <dbReference type="eggNOG" id="ENOG502S5J2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063111_1_0_1"/>
    <dbReference type="OMA" id="WYFALCW"/>
    <dbReference type="OrthoDB" id="5284712at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451">
        <property type="entry name" value="MARVEL DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451:SF3">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="16"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="183"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="251"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS21080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="292" mass="32574" checksum="F8217E1BBA2B57BF" modified="2011-10-19" version="1">MWDDFEVNAEGIPKYKLLFHSFQIIFAFVLWCLEIAVFRHDSAKITGRNGWTFAMPLLTIPAWIYLTMAPRHSRTRKIANPRVMVTVDALYTILWLSAFATQASYNSAGFCGKVCGISKAIVGLGFFVFLFFGVTTFISIWTLKYWEMYNRLPGYDRVQSKNQNIDPDKAAFSLAPHDEEAYAPVSMDDDHEDGRTDYTASTRPPAPRSDYSDPYGPGGAASTVGSSYRDNPFRQHQASSPFDVDTEYHSGRASAAGGRYGSPAPGAVSEVSYADSSQPVRFPDADYDRIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0S837</accession>
    <name>G0S837_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0029250</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693380.1">
        <property type="nucleotide sequence ID" value="XM_006693317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S837"/>
    <dbReference type="GeneID" id="18256963"/>
    <dbReference type="KEGG" id="cthr:CTHT_0029250"/>
    <dbReference type="eggNOG" id="KOG2651">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016581_1_0_1"/>
    <dbReference type="OMA" id="LQAPYNW"/>
    <dbReference type="OrthoDB" id="10258156at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052220">
        <property type="entry name" value="METTL25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496">
        <property type="entry name" value="CGI-41 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496:SF0">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13679">
        <property type="entry name" value="Methyltransf_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="143"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="597" mass="67980" checksum="8780D37E1C7DA896" modified="2011-10-19" version="1">MGEIWNFETRPEKPLPYSDEFSSVDEYVEGLLNFAANSDLFRFLCGGVHILDFFTTDPGLFVDAVPKEWQDYLLQTEPMAFLDFLMRDDLDKISQKSGPVSPPESLVQYVKDIRRFSLRRNFRPRQAKLPVLPRHVALGMKTKKIHEVTHFAGYIDRLAEDIARAKGEDFTHFVDFGSGQNYLGRTLASPPYNKHIVAVESKEANMAGAKDLDILSGFAEREKRVRNKKLYHRLLEMVDPSLHKDEEALKRAAKELGMSDEDIATLDLRSRKELQVTYTVEEGKGTIEYVVGHLEHADLAGVLAQLRGQEDGVCQDKLRMMAISIHSCGNLSHYGIRSMIMNPCIKAVAIVGCCYNLLTEKLGPPTYKPPFSRPSLQPINPRVARESERRDPQGFPMSEKVSTYGGDGIRFNITARMMACQAPQNWTDQESDAFFTRHFYRAVLQKIFLDKGVISRVYHGETASAATPFNSSTNPVIIGSLRKQCYTSFNAYVRGAITKLTTHPDFSQYHQVIQEKMGDITDEEIASYEETFRYRKRELSAVWSLMAFSACVVESVIVTDRWLFLREHSDIVCDCWVETVFDYKQSPRNLVVVGIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0S865</accession>
    <name>G0S865_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Probable guanine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Guanine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0037730</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>guanine + H2O + H(+) = xanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:14665"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; guanine degradation; xanthine from guanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.3" evidence="4"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694195.1">
        <property type="nucleotide sequence ID" value="XM_006694132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S865"/>
    <dbReference type="STRING" id="759272.G0S865"/>
    <dbReference type="GeneID" id="18257811"/>
    <dbReference type="KEGG" id="cthr:CTHT_0037730"/>
    <dbReference type="eggNOG" id="KOG3968">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012358_0_0_1"/>
    <dbReference type="OMA" id="IIASWGK"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008892">
        <property type="term" value="F:guanine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046098">
        <property type="term" value="P:guanine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000022">
        <property type="entry name" value="Guanine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051607">
        <property type="entry name" value="Metallo-dep_hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271:SF6">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="12">
        <location>
            <begin position="80"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00083147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS21899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="478" mass="51825" checksum="82012BFA65E1A75D" modified="2011-10-19" version="1">MTASTAKRKLFLGTFVHSKALSELEYLHDSAIAVDETGKIVAVDKDCGDLAKARETLLPRLGWNEADVEFVQSKDGEFFFPGFIDTHIHASQYPNAGIFGSSTLLDWLNTYTFPLESSLADPVKARRVYARVIRKTLAHGTTCAAYYATINVETTNLLADLCLTAGQRALVGRVCMDSALSPDFYKDASPEAGEEATRKCIAYIKQVDPNMDLVRPIITPRFAPACSAELMKRLGKLAEEENLPIQTHISENKNEIALVKELFPPAVLARATGDESLAKQHESTYAGVYDAFGLLTSRTILAHGVHLTPSELKLIADRGATISHCPCSNSSLASGAAPIRRLLLDHGIPVGLGTDVSGGYSASILEAAREAVLVSRHVCFNAPRDGERDKLSVEEVLWLATRGGARVVGLEGKVGAFEEGMEWDAQLVSLGRVVGEEGDGGMEDEVEGERGNVDVFGWESWPDRIAKRHICATQPNPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8A1</accession>
    <name>G0S8A1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0038090</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694231.1">
        <property type="nucleotide sequence ID" value="XM_006694168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8A1"/>
    <dbReference type="STRING" id="759272.G0S8A1"/>
    <dbReference type="GeneID" id="18257847"/>
    <dbReference type="KEGG" id="cthr:CTHT_0038090"/>
    <dbReference type="eggNOG" id="KOG1943">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003043_3_0_1"/>
    <dbReference type="OMA" id="EPHEAWH"/>
    <dbReference type="OrthoDB" id="10253476at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058033">
        <property type="entry name" value="ARM_TBCD_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033162">
        <property type="entry name" value="TBCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022577">
        <property type="entry name" value="TBCD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658">
        <property type="entry name" value="BETA-TUBULIN COFACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23579">
        <property type="entry name" value="ARM_TBCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25767">
        <property type="entry name" value="ARM_TBCD_2nd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12612">
        <property type="entry name" value="TFCD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin-folding cofactor D ARM repeats" evidence="4">
        <location>
            <begin position="341"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="351"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin-folding cofactor D ARM repeats" evidence="4">
        <location>
            <begin position="424"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin-folding cofactor D C-terminal" evidence="3">
        <location>
            <begin position="937"/>
            <end position="1109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS21935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1206" mass="133388" checksum="81B8807E908DDB86" modified="2011-10-19" version="1">MDAPEDELDIKLQKISGDLIADFNKSLLPFLRKQDGAGKSPVRSHVRTREATRLTASLLDPFQELPQLLDPHLSKWIPILADAFLEYQLTRRHTAAMPSRSELLMPLPRAISKIIYTFCKVRGEKVIVRFLNNEAKYLELLLSALEEAEQAQEPHNQWTWEERYVVLLWLSHLMLAPFDLSTISSHEVEEEELVRIPGFEWPADLPSITTRVLPLAIKYLASPGKERDASKALLVRISMRRDMQQLGVLDALVRWALAALRPTRDEERTPYHYIGVLSFLAGILTISADTSDMDQYLSTIFYAVHGMATEQTNIGSALTRKTIIKVVRAIAVLLLRRPLRDMESLEMVETTIGFLLDNLGDNDTPVRFAASKALSIIALKLDSDMASQVVEAVLEGLNKNVLHVKDRNDPSTPPRKDLSAVDALEWHGLMLTLSHLLYRRSPPAENLAGIVQALMMGLSFERRSASGHSTGTNVRDAACFGIWALARRYTTAELLAVPTPRPDTSIIQILAIELIVAACLDSSGNIRRGSSAALQELIGRHPDTIEHGIWVVQTVDYHAVALRTRALQDVALGATKLSRSYGEAILDALLGWRGVGDVDMASRRAAGTSYGRITAELASTDPNPVNSLAKSVSMVLDRLKSLEARQVEERHGLFLSFAAVLNALPGAMQKWDAAVDKFVRLSMDALLWILEDCNTKTYRRPELIDEAVSRLIISSLPVLQAATSSTETLLSGPSLKNMTGPDLVALINAVEQRPEPLSRIVALINSSLQRALVWQDLDIIAAASQAAVVLMIFSTATERDEIIRGWTDAARARQSSKTRTTSGHFSALAAVYPIASTLALEEDKSLICDAIVERWNTDKQTDTHACILQSLANSELLKQNLSVFLELVAEGLDDYTTTARGDVGSHVRLQAIRATKSLWERLDDLPANNNLTSGLFLRVLRLAAEKLDRVRVEAQAALAVTLKPSYSTELRRLTFSSKAYFSFLLDLLREDWLLPAFSGAKADTEGWVDSLMAGFVSSADTGNEELVIATRAALAEFCERSTANVELICTALARNLKAWQGTDRVLVPTLEVAAFLFHIGVFARCGGVNYKSMCLQVQKACYKTGNVRKIEACIRMYGAIAELGRNAVSTTTETDDAQKIKAGAREARIRLGALMFHPWPRVRAMVVDEVWSLHHDDPAVEDLKGTDWGRAEKSKIKRLVEMLGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8X0</accession>
    <name>G0S8X0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0043720</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694766.1">
        <property type="nucleotide sequence ID" value="XM_006694703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8X0"/>
    <dbReference type="STRING" id="759272.G0S8X0"/>
    <dbReference type="GeneID" id="18258410"/>
    <dbReference type="KEGG" id="cthr:CTHT_0043720"/>
    <dbReference type="eggNOG" id="KOG2043">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002149_2_0_1"/>
    <dbReference type="OMA" id="SWLYHLI"/>
    <dbReference type="OrthoDB" id="342264at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035361">
        <property type="term" value="C:Cul8-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990683">
        <property type="term" value="P:DNA double-strand break attachment to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18436">
        <property type="entry name" value="BRCT_BRC1_like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18437">
        <property type="entry name" value="BRCT_BRC1_like_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18438">
        <property type="entry name" value="BRCT_BRC1_like_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17743">
        <property type="entry name" value="BRCT_BRC1_like_rpt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18439">
        <property type="entry name" value="BRCT_BRC1_like_rpt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000066">
        <property type="entry name" value="BRCT domain protein (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000048">
        <property type="entry name" value="DNA repair protein Rtt107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053036">
        <property type="entry name" value="CellCycle_DNARepair_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47667">
        <property type="entry name" value="REGULATOR OF TY1 TRANSPOSITION PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47667:SF1">
        <property type="entry name" value="REGULATOR OF TY1 TRANSPOSITION PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16770">
        <property type="entry name" value="RTT107_BRCT_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="6"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="104"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="336"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="617"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS19881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="844" mass="94789" checksum="5EC37917C894D409" modified="2011-10-19" version="1">MADEPHKGGLFENCKIAFVQSKALTSVAISQYSSLIRENGGEILEPDRRGKIPIPGATHIISDTIDFDQYTEALAFMIPVVRHEWINLSIARHRLAQVRPFSPDPRMIFSSVILTCADIPEMDKESIAGAIIALGGVESKDLTRQTTHICALSLDHPKCVEARKKNLKCKIVLPHWFDDCFRLGKRIDEGPYLLPDPEILRKAPEEAVKIPSSQGLDGAVSVVPQGPYNTDGGEKLVVFEQRKVMLSRDLPITPQLRKTITDKIIRGGGQVVDDVDDCDWFVCQFRDGPQYIRASQQGKEVGNLAWLYHLIVYNEYTSPMRRLLHYPIPRDGLPGFKGMRITISNYGGDARIYLENLIKAAGAEYTKSMKSDNTHLITARLHSEKCEAAKDWNIEIVNHLWIEESYAACEPLPLTNPKYQHFPPRTNLGEVVGQTFLNPVVLRQRYFPGGEETMNEEAKMKHKVNERAQKNALKVGLDRDFNVMQESSPAGQSTKKTRRSAPTTGAFSTPAKGRHVSDGKENETPSTMFSSASRSAKAQALSKLHDLSADIALYEKEKKRTKDGIFGGKRAADQIEKERVVENTASPASDKRPREDVDDMQDKRPAKRAKTSLPEADMRICLTGYKRWAGDKSSEEADRKKLRALGIQIVQDTVPFTHLAAPSMIRTQKFLVALAKGPDVISSDFVTACIEKGKRPNVDDYRLRDKAGEEKFGITIETAVARARANRGRLLFKMPIYCTEKIPNGPQAFEAIAKANGAIFMLYRGRPTIKPTTPEEDGGAPPEPVYLLSGPSEAEKQLWPRFEEMAIKGHMEPRIVVADWLLDVCMRQELFWDPRYLWKNREKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8X7</accession>
    <name>G0S8X7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="11">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Transfer RNA methyltransferase 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TRM8</name>
        <name evidence="13" type="ORF">CTHT_0043800</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10 11">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms a complex with TRM82.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="11"/>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694773.1">
        <property type="nucleotide sequence ID" value="XM_006694710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8X7"/>
    <dbReference type="STRING" id="759272.G0S8X7"/>
    <dbReference type="GeneID" id="18258418"/>
    <dbReference type="KEGG" id="cthr:CTHT_0043800"/>
    <dbReference type="eggNOG" id="KOG3115">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050910_3_1_1"/>
    <dbReference type="OMA" id="LPNYFAK"/>
    <dbReference type="OrthoDB" id="47276at2759"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106143">
        <property type="term" value="C:tRNA (m7G46) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine(46)-N7)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000060">
        <property type="entry name" value="tRNA (guanine-N(7)-)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03055">
        <property type="entry name" value="tRNA_methyltr_TrmB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025763">
        <property type="entry name" value="Trm8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00091">
        <property type="entry name" value="tRNA (guanosine(46)-N7)-methyltransferase TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="3-DEOXY-D-MANNO-OCTULOSONIC-ACID TRANSFERASE/TRNA GUANINE-N 7 - -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417:SF16">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 11" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="82"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="158"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="193"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="291"/>
            <end position="293"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS19888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="317" mass="36382" checksum="26C026026C82A61A" modified="2011-10-19" version="1">MGNAKQNKQSQKNGDSAKAKRDRRQKREEYRAAMKQEGVAELPRKKFYRQRAHANPFSDHRLVYPPHPDMMDWSVLYPDYAVDEPKEDTPAPAQESSEQSVQEGQQETSPESQSQSIVSLNPRKLSKQVEVADIGCGFGGLLVALAPLMPDTLILGLEIRVSVTQFVEDRIKALRLKHKDTQAYRNVGVLRANTMKFLPNFFHKGQLTKIFICFPDPHFKARKHKQRIVSTTLNSEYAYVMRPGGVVYTITDVLDLHEWMVQHFTAHPSFERVSEEEVENDPCVGVMKTETEEGKKVERNKGNKYVALFRRLPDPEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8Y9</accession>
    <name>G0S8Y9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0043930</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694785.1">
        <property type="nucleotide sequence ID" value="XM_006694722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8Y9"/>
    <dbReference type="GeneID" id="18258431"/>
    <dbReference type="KEGG" id="cthr:CTHT_0043930"/>
    <dbReference type="eggNOG" id="ENOG502SNRP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103066_0_0_1"/>
    <dbReference type="OMA" id="GVERFEY"/>
    <dbReference type="OrthoDB" id="4124983at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053146">
        <property type="entry name" value="QDO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36440">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_8G07350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36440:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_8G07350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="44"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="160" mass="17723" checksum="FA7181DF2AFD3C79" modified="2011-10-19" version="1">MPIRGPVPVKLYKLDKAETLRIGPLTIRVYEDGSLTENRVSSILIEIPAGQSGPPMHWHRFHDELFFVTKGRVAFITPTNEVVASAGDLMTIPPGAIHTFKNASSTEDAECYMTATPGQYVDYFRMLAKVTQAGKPLTMNDVRHMMALFGTFPPDVDSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9A0</accession>
    <name>G0S9A0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative exosome complex protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0045080</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2024" name="bioRxiv" volume="0" first="0" last="0">
            <title>Beyond static structures: quantitative dynamics in the eukaryotic RNA exosome complex.</title>
            <authorList>
                <person name="Liebau J."/>
                <person name="Lazzaretti D."/>
                <person name="Bichler A."/>
                <person name="Pilsl M."/>
                <person name="Sprangers R."/>
            </authorList>
            <dbReference type="DOI" id="10.1101/2024.01.28.577622"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.19 ANGSTROMS)</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694896.1">
        <property type="nucleotide sequence ID" value="XM_006694833.1"/>
    </dbReference>
    <dbReference type="PDB" id="8PEL">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.81 A"/>
        <property type="chains" value="H=1-358"/>
    </dbReference>
    <dbReference type="PDB" id="8R1O">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.19 A"/>
        <property type="chains" value="H=1-358"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9A0"/>
    <dbReference type="EMDB" id="EMD-18825"/>
    <dbReference type="SMR" id="G0S9A0"/>
    <dbReference type="STRING" id="759272.G0S9A0"/>
    <dbReference type="GeneID" id="18258546"/>
    <dbReference type="KEGG" id="cthr:CTHT_0045080"/>
    <dbReference type="eggNOG" id="KOG3013">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034114_0_0_1"/>
    <dbReference type="OMA" id="GVNGFIW"/>
    <dbReference type="OrthoDB" id="1650at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05789">
        <property type="entry name" value="S1_Rrp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000038">
        <property type="entry name" value="Exosome complex component RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025721">
        <property type="entry name" value="Exosome_cplx_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048565">
        <property type="entry name" value="S1_RRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF4">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14382">
        <property type="entry name" value="ECR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21266">
        <property type="entry name" value="S1_RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="12 13" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-0271">Exosome</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exosome complex component N-terminal" evidence="8">
        <location>
            <begin position="61"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="RRP4 S1" evidence="9">
        <location>
            <begin position="112"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS20011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="8PEL"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="8R1O"/>
        </source>
    </evidence>
    <sequence length="358" mass="38361" checksum="996F7548395562EC" modified="2011-10-19" version="1">MPITIHAPLPPPRLHDEDSDVDMSSDSDSSSEGGVPLTSNLPSRAKPKSSLFTTTKSSSDIVTPGELITTSPQFMRGHGTYIPPGTTSIISSVAGTILRTNKLLSVRPLRARYTPEVGDLVVGRIIEVQARRWRVDVGSTQFASLPLSAINLPGGILRKRTETDELQMRSFFSEGDLLVAEVQGVYGDGGAVLHTRSLKYGKLRNGVFVAVSGMGGGGGVVRSRRQVWTLEGANGAGLIDVVLGVNGYVWIAKHTEDGPGEDPNASTKQVGITNLEEGMSANMYSSQNDRIEAETMREIARLRGVVMALVENGLRVDEDMVMRGYREAVEMALVSPEGPEDVYLGGERGRQLAAALTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9D4</accession>
    <name>G0S9D4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Parallel beta-helix repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0045440</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694930.1">
        <property type="nucleotide sequence ID" value="XM_006694867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9D4"/>
    <dbReference type="GeneID" id="18258582"/>
    <dbReference type="KEGG" id="cthr:CTHT_0045440"/>
    <dbReference type="eggNOG" id="ENOG502R351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041546_0_0_1"/>
    <dbReference type="OMA" id="DVCGTIN"/>
    <dbReference type="OrthoDB" id="5576103at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409413" evidence="1">
        <location>
            <begin position="20"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="356" mass="37486" checksum="F9033B4C589FC250" modified="2011-10-19" version="1">MKKVTTFLFAALLPATALSQSCGSGNPDIRVTSSGNNFVATRSNGAQVYSGSDYRQAIQSALDSISYGQRVVVTASGSIGASTITISSGKTLEVCGTINVGYRAGRGAIESTNTNDVSIPYLTMTGNPYFGLRFSGTRNLKLGKITMNLSGGLGIRFDRDAAQNYNVLMDEIRVTGAGSHAVETWNIDGLQVGSVIARNVGECGLLLQKTTNARVGLVDGENVATGNGYATFRMANENGKLSNGQYTTNVYVDRVVSRGGGRGIFCVSQSGGAEINNVDLANNGNNAILIENCYNVKIKSGTVNGGGEVRLAARSEFANNRDISLTLTVNNNSVREQPCGTNIQWNISGNAKKTIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9P2</accession>
    <name>G0S9P2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0046600</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695038.1">
        <property type="nucleotide sequence ID" value="XM_006694975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9P2"/>
    <dbReference type="STRING" id="759272.G0S9P2"/>
    <dbReference type="GeneID" id="18258698"/>
    <dbReference type="KEGG" id="cthr:CTHT_0046600"/>
    <dbReference type="eggNOG" id="ENOG502SGJJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023631_0_0_1"/>
    <dbReference type="OMA" id="SDSFYMA"/>
    <dbReference type="OrthoDB" id="5329403at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="602"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="572"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS20153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="716" mass="77001" checksum="B7B6FBF80D3D5254" modified="2011-10-19" version="1">MTPSNGVNSVNGVNGVNSLNGVANKTKPTTRRVPAKVVVPALPLNYPQRPLKTTTTVTKATEVTSPTSNPQSIAPQPTAEKLAQDVIGKPASSDLALGPSKKLNPTAPAISFKQDPASEPSTASVVADEREKDTPPVSSALPKRINSPARQRPPGPANPAPEAQTAPGGVIPEASHPAPHPAALMNRPAFHQPHPSNGSLVFGGIHDSNASSPAPRSGSFPPPGLLPYPPVTGVDGYGRPLVDGYPPNLAASHHGPPTPHSFQGSQSSVQADEHAVFNHYPAVNGHNGYPVDPTAQAPIPVLGLHPPMNGVSSVAAYQSVRIQDEALFFLRNGFPDDTWNDCVIKVRFADSPEFRVLATGHRFIFSRSPTLATVMKAQRTMPGSEIFLEAHDKYIRPDVMWYALRTLYGWPIAEGPLPSELQPRDVRDDFDTALSYLATGRFLRLPWVHAVGSARASYLLCWDTIEQAVKFVSQAVALSPRDDGFGVSELLSHVLDFLVHHFPTNLVLDTNAGDLGFSRLPPVPSQKSATPPIVNGTSHSRQPSVAHIPKNPRLSANHRLSQIKFGDISPLNGANNNPNGKAAPSESVQSPRAPSPNDTLFSRILLNLPFELLKQVLEHPNLGKLNGELSPVARQSIISDIIAEREARRMRTLEKVDHPQLRTFQDRLDNAGAPLVVSCIEDFWVNSMGFKEEVFSGDLPYLVHTWTQGSASSVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9R8</accession>
    <name>G0S9R8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0046910</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695064.1">
        <property type="nucleotide sequence ID" value="XM_006695001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9R8"/>
    <dbReference type="STRING" id="759272.G0S9R8"/>
    <dbReference type="GeneID" id="18258729"/>
    <dbReference type="KEGG" id="cthr:CTHT_0046910"/>
    <dbReference type="eggNOG" id="ENOG502S5YP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1864901_0_0_1"/>
    <dbReference type="OMA" id="PMIHVKA"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS20179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="137" mass="15362" checksum="C03C9E6E6CDF9530" modified="2011-10-19" version="1">MSSDSKPFTVGITGITGRLGRLLLSALLTSRPKVHIRDALSLLALREFVSWCDVVACCYLGDNKSMTEGQKLLIDLCEEFGVKDPTKEIKAYPETKDKVKVVHLLIGRFMNALLAPFFGLWDGQDMVLRYGKRKQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9W4</accession>
    <name>G0S9W4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="15">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CTHT_0047410</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 22">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="15"/>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695110.1">
        <property type="nucleotide sequence ID" value="XM_006695047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9W4"/>
    <dbReference type="STRING" id="759272.G0S9W4"/>
    <dbReference type="MEROPS" id="C19.A65"/>
    <dbReference type="GeneID" id="18258779"/>
    <dbReference type="KEGG" id="cthr:CTHT_0047410"/>
    <dbReference type="eggNOG" id="KOG0944">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009884_1_0_1"/>
    <dbReference type="OMA" id="FVPCEHT"/>
    <dbReference type="OrthoDB" id="361536at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02658">
        <property type="entry name" value="Peptidase_C19B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14385">
        <property type="entry name" value="UBA1_spUBP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14386">
        <property type="entry name" value="UBA2_UBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000086">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000396">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000587">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000235">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000144">
        <property type="entry name" value="Ubiquitinyl hydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016652">
        <property type="entry name" value="Ubiquitinyl_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041432">
        <property type="entry name" value="UBP13_Znf-UBP_var"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF664">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17807">
        <property type="entry name" value="zf-UBP_var"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016308">
        <property type="entry name" value="UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 15" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 15" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="19">
        <location>
            <begin position="149"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="18">
        <location>
            <begin position="300"/>
            <end position="774"/>
        </location>
    </feature>
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        <location>
            <begin position="581"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="17">
        <location>
            <begin position="641"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="681"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="730"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="195"/>
            <end position="198"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGS20225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="774" mass="85399" checksum="188CDE2A275A4D61" modified="2011-10-19" version="1">MACPHIAPAYISKPSISDSVYREDCTLCFDSIDDPAGLDVCLKCFNGGCAGDRQHAKLHSVARQHPLVLNIRRSRKRIERDEPPLKKLAIAAETEADRYETTLTVKCLECGIANLDKSNPTIAEAVDGVMAANTFSRKEEIKAWELELTTCEHIITLQQGEPRQIESQDLGHCSKCDLKENLWLCLECGNLGCGRAQFGGVGGNSHALAHSEEFGHGVAVKLGSITPEGSADVYCYKCDEERIDNDLATHLANWGIVLSERKKTEKSLTELQIEQNLRWEFSMTTEDGKELSPLFGPGLTGLKNLGNSCYLASILQCLFDMPSFQARYGTGVESLPDVPDPAQDLETQLRKIADGLLSGRYSKPDSDVIVSEHSPEVPYQKGLQPSMLKHLIGRGHPEFSTMRQQDAFELLQHLIKLITRSKHPSGHTDPTQAMRFVTEQRLQCLGCKKVRYSTTEQDSILIDVPLKLSAADGEVPKYKPVTFKQCLDNFTAPEVVELTCTTCGSKDGFTKRQLFKTFPETLVVNTRKMAVINWVPIKVDVPVIVDDEPFTLDEYLSPGQQPGEELLPEEAAPASNVPAFVPNQEALAMLEGMGFPRVRCEKALHATGNGDPNAAMEWLFQHMDDPDLDVPADFGNAAPATVDPENLAILESMGFGGPRAARALKETGGNVERAIDWLFNHPDDQGDAEENAGASGSDKQGPLAGSAHLPARFQLQSIVCHKGTSIHTGHYVAFIRKKLNDETAWVLFNDEKVVKATDMDEMKQSAYIYFFRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G0SA51</accession>
    <name>G0SA51_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0041020</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006694445.1"/>
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    <dbReference type="STRING" id="759272.G0SA51"/>
    <dbReference type="GeneID" id="18258140"/>
    <dbReference type="KEGG" id="cthr:CTHT_0041020"/>
    <dbReference type="eggNOG" id="ENOG502S8CY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004543_1_0_1"/>
    <dbReference type="OMA" id="NDTRIFS"/>
    <dbReference type="OrthoDB" id="5346713at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902412">
        <property type="term" value="P:regulation of mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045342">
        <property type="entry name" value="Etd1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20162">
        <property type="entry name" value="Etd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
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        <location>
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            <end position="747"/>
        </location>
    </feature>
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        <location>
            <begin position="869"/>
            <end position="892"/>
        </location>
    </feature>
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        <location>
            <begin position="949"/>
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        </location>
    </feature>
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        <location>
            <begin position="995"/>
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        </location>
    </feature>
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        <location>
            <begin position="1052"/>
            <end position="1122"/>
        </location>
    </feature>
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        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
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        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
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        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
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        <location>
            <begin position="412"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="652"/>
            <end position="665"/>
        </location>
    </feature>
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        <location>
            <begin position="707"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="963"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1004"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1052"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1077"/>
            <end position="1107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1122" mass="121803" checksum="E7D921392AE7EBC4" modified="2011-10-19" version="1">MQAVPSLVGAGTAVAAAAVGLVFGQPPEAETPAHSIFPADYDGFRAQSPLPPRPNTSAAALCQPSSPLADDSLYSPLQLSDIGPGPLSPLATSSANIPRPATAAQLSSPKSEWMRPFFLRSSDPTPKATVENARDSSSSRESWMRRLSLRPLSQHGSPRSSTAPDSSSMSFSHSSAVPMLGHPQSVHAAPNKLIKRSRLNGPASGSQRRGSQALTLRRPATSHQRAATLQLMQQQIQQTQQNATVLEPISPDPKLSLDMSVLSPTSPIYAEPKRASGKWASFFHARRSSSLNRDLSGLPSAAIHYHHVMFPRKKLSIPFGRVVRAYLTKPDQLDDIPPLTYESDPAQEKSAQEEQRTSTPDLFVSDEPTPDERPKRSLSMHFLSRPSIRRRRRSTIGAKNGHARYLSDPGTALQSTIQNPVGQESDSTHEPTAALQGPETGVPTSLELPLSRRRNSPSPLPPLNRLSTFSIDLSKIGEATSISVDGSRRIPTPINYARGPQTPSSLAHSRGPSGQQSLTLAGSDFDSRGTFGDEDTDLRSDGMYDSFRTGASSSRMRSVETPIESMFDESPPSSACHCRTKRLSVQEMLGPSWDGETKIIEEDETLPMANGVSYQSMGPNSNNSLSLVTHDLGRLSFDDENDDDWARDDENTLSNHLSPPGSANSRRIPFPLRQALKSTNGGENLAPPRESIDSRPRSSIFDWSEPSVHDKHDTDTPRPKTVHGKQELDLRGGRPTTRKPPGAAHVRSQSVPIVPDLVDSSKPQPRFGTWGLGTKTVSEDWDDDFEFEGDDLATSTIAGKDSATSFSVVVPASIQATQPSVRAHSGQIRELSLLVNDLKRLCRHGKELDILNGPAAAKFSEAESIIVLASPDEEEPKPASPSKSSREFDRSDVDDRFLDEGFDGPVLDNSDDSFDFPDFPDLDIEMSKTAVVRERPGVRRRSVFSPEDDIFGGNWPLNDGNASSSSPRPRTPSRTSTPNRTSAVVSAVIEVLQQQQRAGKLDNSKASPFKSTPTTPTTKLFFDTNSLQELVKRASQLRDALSEVVRKAELLTQSPVSTPRRSERSSSQGRNLDGSPAFTSVFDNHPSTGSSPQTRLPNSQSGSTILSKASVDAMRMPMMTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>G0SA77</accession>
    <name>G0SA77_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0041280</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694534.1">
        <property type="nucleotide sequence ID" value="XM_006694471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SA77"/>
    <dbReference type="GeneID" id="18258166"/>
    <dbReference type="KEGG" id="cthr:CTHT_0041280"/>
    <dbReference type="HOGENOM" id="CLU_1467982_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="184" mass="20346" checksum="D19BAA68325A00DC" modified="2011-10-19" version="1">MPNNLAVPNTPRGQSGSLSPSSPDQTSSFQHPNTSDTNSEQTAIHDRDTIPGGPASTKPKGAIDNLIDDLYDWLEVLPRICDGNLPAKFVVTLLLQSYLNDRLRPNITWLMASADLLSLLCEYCLCGLLHRGFSDAEVRAGRCVCEKYRNVWTFKFCVRVRRVEEGADGRLQFIRGPLVPQGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0SA82</accession>
    <name>G0SA82_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0041330</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694539.1">
        <property type="nucleotide sequence ID" value="XM_006694476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SA82"/>
    <dbReference type="STRING" id="759272.G0SA82"/>
    <dbReference type="GeneID" id="18258171"/>
    <dbReference type="KEGG" id="cthr:CTHT_0041330"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004893_0_0_1"/>
    <dbReference type="OMA" id="PHWVRTE"/>
    <dbReference type="OrthoDB" id="2336090at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF19">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="145"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="330"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="281"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="469"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="649"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="701"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="845"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="474"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="659"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="724"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="758"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS19654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="941" mass="104189" checksum="3ED21F021C254AC5" modified="2011-10-19" version="1">MNTASVGLAVTPAVVSTLLSHYLNRKPLAHKPTEHLSYDEGLHLIRSFLEHSSKYTVEDLQAFSSQWVPHPQWVRVDHVEIPEDHLSKAADLLIDQLGPEGLRKVGGSKWWQWRKPKSPLKAEWIEMKADYRERRKRGDPGNRVMLYVHGGAYYFGSIDMHRYQIQRHARKLKARALAPDYRLAPQFPFPCGLQDCLATYLWLISQQKPSTVILAGDSAGGGMVLSMLVVLRDRGIPLPAGAVLISPWCDLTHSFPSVAEDCPLDYIPPTGFHHKPSIAWPPPNEEELKEMSKLASGDTDDGDEKVNQSEKKASPTTPLSVIIDGENVEIKEQIQMYTTNELITHPLVSPVLQPTLGGLPPLLVLVGGGEILRDEQIYLAHKAANPSAYLPPEACLDEEARALIDRYPPTDVQLQVWDDLCHVAPTLSFTRPAKLMFRSIAQFSAWALARAQESDIEIQHDDHISVITSSSDSSLERAQTHLSEEEKKHATSSIGKAGDPLPPFENHMIRQRVTRHGRIFPLAPPEELPGCCMPREEIGVIKESTARKWLDKRRKWDARFADARARVRRQRLRDASAGFETFGEGENPPPSALAGRRKIGVFKEAECKRKRVKSFGMSLWATWGAKHDLMAVKREKESDKAPEQVIVNAEQGQGARTFESLEKQEEEVRHREEEKKDKKKRGLSVERFVRKSRSWRDLFSLGKSQQEQNAKDVPPVPPLVTPASDEKTTENKTETTDNGAETEATNGQATEPVANEAPTKENGDANPKPDEIAEPHAAAPADGETGVTGKRVFLGGVAMPFSLRKEADSASLMTLMSTPMTPGLPPSINTTQAEGAEIEVPSPVTETAGHTAEGEKTPVLPPTTPTVLINDPIEEEKTTVANGDVNGDDTKEVVIELPEKKQPELARLDFSTPLPSPALTGDASLERFITADSRADDSPKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-06-24" modified="2025-04-09" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAK3</accession>
    <accession>G3EQ75</accession>
    <accession>G3EQ76</accession>
    <name>NU145_CHATD</name>
    <protein>
        <recommendedName>
            <fullName>Nucleoporin NUP145</fullName>
            <ecNumber>3.4.21.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Nuclear pore protein NUP145</fullName>
        </alternativeName>
        <component>
            <recommendedName>
                <fullName evidence="4">Nucleoporin NUP145N</fullName>
                <shortName>N-NUP145</shortName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="4">Nucleoporin NUP145C</fullName>
                <shortName>C-NUP145</shortName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name type="primary">NUP145</name>
        <name type="ORF">CTHT_0042590</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope. NUP145 is autocatalytically cleaved in vivo in 2 polypeptides which assume different functions in the NPC. NUP145N as one of the FG repeat nucleoporins participates in karyopherin interactions and contains part of the autocatalytic cleavage activity. NUP145C as part of the NUP84 complex is involved in nuclear poly(A)+ RNA and tRNA export.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 6">Component of the nuclear pore complex (NPC). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof.</text>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-16069276">
            <id>G0SAK3</id>
        </interactant>
        <interactant intactId="EBI-16069391">
            <id>G0S2G1</id>
            <label>ELYS</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>5</experiments>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-16069276">
            <id>G0SAK3</id>
        </interactant>
        <interactant intactId="EBI-16069242">
            <id>G0S0E7</id>
            <label>NUP120</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>12</experiments>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-16069276">
            <id>G0SAK3</id>
        </interactant>
        <interactant intactId="EBI-4325187">
            <id>G0S4T0</id>
            <label>NUP192</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>3</experiments>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-16069276">
            <id>G0SAK3</id>
        </interactant>
        <interactant intactId="EBI-16176422">
            <id>G0S4F3</id>
            <label>NUP82</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>2</experiments>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-16069276">
            <id>G0SAK3</id>
        </interactant>
        <interactant intactId="EBI-16069259">
            <id>G0SDQ4</id>
            <label>NUP85</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>7</experiments>
    </comment>
    <comment type="subcellular location">
        <molecule>Nucleoporin NUP145C</molecule>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Nucleoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="1">Symmetrically distributed on the cytoplasmic and nucleoplasmic side of nuclear envelope.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Nucleoporin NUP145N</molecule>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Nucleoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="1">Biased towards the nucleoplasmic side, nuclear pore complex.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited. FG repeat types and their physico-chemical environment change across the NPC from the nucleoplasmic to the cytoplasmic side: GLFG repeats are especially abundant in NUPs in the central region (lacking a charged environment but are enriched in Ser, Thr, Gln, and Asn).</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">NUP145 is autocatalytically cleaved in NUP145N and NUP145C.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nucleoporin GLFG family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-"/>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JF276292">
        <property type="protein sequence ID" value="AEN86178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JF276297">
        <property type="protein sequence ID" value="AEN86179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694660.1">
        <property type="nucleotide sequence ID" value="XM_006694597.1"/>
    </dbReference>
    <dbReference type="PDB" id="5CWW">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.20 A"/>
        <property type="chains" value="A=858-993"/>
    </dbReference>
    <dbReference type="PDB" id="5HB0">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.50 A"/>
        <property type="chains" value="E/F/G/H=729-750"/>
    </dbReference>
    <dbReference type="PDB" id="5HB5">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.50 A"/>
        <property type="chains" value="A/B=858-993"/>
    </dbReference>
    <dbReference type="PDB" id="5HB6">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.30 A"/>
        <property type="chains" value="A/B=858-1000"/>
    </dbReference>
    <dbReference type="PDB" id="7MVV">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.22 A"/>
        <property type="chains" value="C=616-683"/>
    </dbReference>
    <dbReference type="PDB" id="7MVZ">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.81 A"/>
        <property type="chains" value="C=640-732"/>
    </dbReference>
    <dbReference type="PDBsum" id="5CWW"/>
    <dbReference type="PDBsum" id="5HB0"/>
    <dbReference type="PDBsum" id="5HB5"/>
    <dbReference type="PDBsum" id="5HB6"/>
    <dbReference type="PDBsum" id="7MVV"/>
    <dbReference type="PDBsum" id="7MVZ"/>
    <dbReference type="AlphaFoldDB" id="G0SAK3"/>
    <dbReference type="EMDB" id="EMD-24057"/>
    <dbReference type="EMDB" id="EMD-24059"/>
    <dbReference type="SMR" id="G0SAK3"/>
    <dbReference type="DIP" id="DIP-60574N"/>
    <dbReference type="DIP" id="DIP-61561N"/>
    <dbReference type="IntAct" id="G0SAK3">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0SAK3"/>
    <dbReference type="MEROPS" id="S59.A07"/>
    <dbReference type="TCDB" id="1.I.1.1.2">
        <property type="family name" value="the nuclear pore complex (npc) family"/>
    </dbReference>
    <dbReference type="GeneID" id="18258297"/>
    <dbReference type="KEGG" id="cthr:CTHT_0042590"/>
    <dbReference type="eggNOG" id="KOG0845">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002330_0_0_1"/>
    <dbReference type="OMA" id="PMGKGLN"/>
    <dbReference type="OrthoDB" id="3797628at2759"/>
    <dbReference type="EvolutionaryTrace" id="G0SAK3"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034398">
        <property type="term" value="P:telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2360:FF:000001">
        <property type="entry name" value="Nuclear pore complex protein Nup98-Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1610.10:FF:000003">
        <property type="entry name" value="Nucleoporin SONB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1610.10">
        <property type="entry name" value="Peptidase S59, nucleoporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037665">
        <property type="entry name" value="Nucleoporin_S59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007230">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036903">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021967">
        <property type="entry name" value="Nup98_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP98-NUP96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198">
        <property type="entry name" value="NUCLEOPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04096">
        <property type="entry name" value="Nucleoporin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12110">
        <property type="entry name" value="Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82215">
        <property type="entry name" value="C-terminal autoproteolytic domain of nucleoporin nup98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51434">
        <property type="entry name" value="NUP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0509">mRNA transport</keyword>
    <keyword id="KW-0906">Nuclear pore complex</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000433184" description="Nucleoporin NUP145N" evidence="6">
        <location>
            <begin position="1"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000433185" description="Nucleoporin NUP145C" evidence="6">
        <location>
            <begin position="994"/>
            <end position="1793"/>
        </location>
    </feature>
    <feature type="repeat" description="GLFG 1">
        <location>
            <begin position="50"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="repeat" description="GLFG 2">
        <location>
            <begin position="143"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="GLFG 3">
        <location>
            <begin position="255"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="repeat" description="GLFG 4">
        <location>
            <begin position="282"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="repeat" description="GLFG 5">
        <location>
            <begin position="292"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="repeat" description="GLFG 6">
        <location>
            <begin position="306"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="repeat" description="GLFG 7">
        <location>
            <begin position="336"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="repeat" description="GLFG 8">
        <location>
            <begin position="381"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="repeat" description="GLFG 9">
        <location>
            <begin position="395"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="repeat" description="GLFG 10">
        <location>
            <begin position="434"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="repeat" description="GLFG 11">
        <location>
            <begin position="446"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="repeat" description="GLFG 12">
        <location>
            <begin position="470"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="repeat" description="GLFG 13">
        <location>
            <begin position="481"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="repeat" description="GLFG 14">
        <location>
            <begin position="496"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="repeat" description="GLFG 15">
        <location>
            <begin position="514"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="repeat" description="GLFG 16">
        <location>
            <begin position="539"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S59" evidence="2">
        <location>
            <begin position="857"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="404"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="740"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Nucleoporin RNA-binding motif (NRM)" evidence="1">
        <location>
            <begin position="859"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="999"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1066"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="417"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="467"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="500"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="518"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="546"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="801"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="814"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="826"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="999"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1025"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="strand" evidence="7">
        <location>
            <begin position="860"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="helix" evidence="7">
        <location>
            <begin position="866"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="helix" evidence="7">
        <location>
            <begin position="874"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="strand" evidence="7">
        <location>
            <begin position="879"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="strand" evidence="7">
        <location>
            <begin position="884"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="turn" evidence="7">
        <location>
            <begin position="888"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="strand" evidence="7">
        <location>
            <begin position="891"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="helix" evidence="7">
        <location>
            <begin position="906"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="turn" evidence="7">
        <location>
            <begin position="910"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="strand" evidence="7">
        <location>
            <begin position="913"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="strand" evidence="7">
        <location>
            <begin position="920"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="helix" evidence="7">
        <location>
            <begin position="927"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="strand" evidence="7">
        <location>
            <begin position="941"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="helix" evidence="7">
        <location>
            <begin position="958"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="strand" evidence="7">
        <location>
            <begin position="975"/>
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        </location>
    </feature>
    <feature type="turn" evidence="7">
        <location>
            <begin position="981"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="strand" evidence="7">
        <location>
            <begin position="985"/>
            <end position="991"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P49687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="21784248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <evidence type="ECO:0000305" key="6">
        <source>
            <dbReference type="PubMed" id="21784248"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="5HB6"/>
        </source>
    </evidence>
    <sequence length="1793" mass="188540" checksum="4A7B65CC8B6C91B5" modified="2011-10-19" version="1" precursor="true">MSFGFGSGGFGQNNNSSTFGGFGSTPTTNTGFGSTGTTAFGSTSNTTGGGLFGGGGGGFGSGNTFGSGFGSKPAFGTPATTSSTSLFGSTTTTAGGTGFGSGGFGSTNTSSPFGGGGTSLFGNKTTTGFGSGTSTFGSNTGGGLFGGGSTTTGFGATNNPGIGTNVGDPPGTAVVPFSPTVEKEVNNPSQSNSYQNILFMDAYKKWSAEELRLADYNQGRKTAAPGGTGAFGSSGFGGFGTTSNTGGFGSNTGGGLFGNTQQNTGGFGTTNTTGSAFGSGGGLFGNKPATGGLFGTSSSQPAQSGGLFGSGTASTFGSSNTGTTSTFGSNNNTGGGLFGSNNTSSKPAFSFGTSNTSTPGFGTATTGSGFGTGTTTNTGGGLFGNTAQNTNTGGGLFGNQQQSGSAFGSGTGFGQQNQSTGTSLFGNTQQKPGGLFGSTTTNTSGGLFGSTNTGTSTFGQTPATQNTGGGLFGSKPAGTGGLFGSTATNQPASTGGLFGNLNTNAQTQQPATGGLFGNLGQNNQAKPSLFGTSTTTGGGLFGNTNAQQQTGSLFGTSTAQQQPQTGLGASLFGSSQQQQQQPQTFSTSITDISAYGATTLFSGLPDDKIQNPGPLATPLSGKAKVKSRSILPMYKLSPANASRLVTTPQKRAYGFSFSAYGSPTSPSSSASSTPGAFGQSILSSSINRGLNKSISASNLRRSLNVEDSILQPGAFSANSSMRLLGGPGSHKKLVINKDMRTDLFSPPNKDKQPQEDGTAARKTVTKRVSFDTSNVETPEKTIESSIPATDDSGYLKPDARSTANGTNGANGAKSSPVAAASPPEMEQVKGKELAVVHEEESPAPAQTDKPRGSQIEPGAYWMSPTADDIRAMNRMQRQRVVGFTVGRENVGSVQFKVPVDLSNINLDDLFGTIVILEPRSATVYPNAAKKPPMGKGLNVPALISLEHSWPRGGPTIKGRRLERHIERLKSIPDTTFESYDPETGVWAFSVEHFTTYGLGDDDDYDDDDYETEPESAVKSTPRPVTSPSISKSSTSPIDPDDTFEFRRSRRALPGAFDDAALSDTDEVANHAQRQGTLSPEPQDADTPLPSREWPEDESMADGLDEYQLEAYEEASQQGSVDEQEDFLPSRFAADNDAPQVPAGIMRARMRAVKKLNAPTKIEVAGGDDWTQILQASVKAPRTMDRATLRALNESGAVWEMKDRGSPPPQATATVSDGMGFATSIDLMKSLFEQAKAPTQPALTTSGKGFVKWPYEQRSKTDTEENLAVPRTNWGPNELLISTQHNEPNLLPVDAADDSATSPSTLARLQQYINLVSSKKQLQRVAGPEFRELAQGDSVWELAALLFDDNGEGVSQFWQQLVSEATDRALSFTAGLEEKAIICLAGNRVDEACRHLLAAGNFRLATLVSTIGKVDNKDIRAQLKDWRESNVLAEFSEPIRAIYELLAGNASVCAGVKNVPIENRVNSFTISQRFGLDWMRSFGLRLWYTSGVIPDVAAAVRSFQEDIEQDREPEPDSALWTLLKAFASREYDWSDTRLGWLLTKAIYTTGKVSFGEDALQKLDKASVTFASALTAASHWVPATFVLLQLSDPASREAAVRDHLGRHAHRIGSPRNLMSPFFTLQKFGVPEAWIWEAKALDYRSRQDSQQEFLALIWAQNYAEANRTFVTRVGPDLVIERNLPRLFAFAQLLFKVKKHLPNWERSAAVYLLYPMAVMQNQGSGKLDRFDNQLIDGLVALHSQTHGDIRQEAAIADMAEELIKCKGAAAASDPRLLQLLPQDVRGKYLRAQVLEAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAK9</accession>
    <name>G0SAK9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0042650</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694666.1">
        <property type="nucleotide sequence ID" value="XM_006694603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAK9"/>
    <dbReference type="GeneID" id="18258303"/>
    <dbReference type="KEGG" id="cthr:CTHT_0042650"/>
    <dbReference type="eggNOG" id="ENOG502RIBF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_678232_0_0_1"/>
    <dbReference type="OMA" id="YCALERI"/>
    <dbReference type="OrthoDB" id="4940902at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS19781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="39236" checksum="3DA5505EB0C8CEFB" modified="2011-10-19" version="1">MGSGLSSWLALARSFQLVGGLAAAVMHGFLTIKVHTEKFGLTHHMSFLAILICAVFGYTTLALSIQHTGGRSKKPLVLICFLIGDVLVCAVLLLIITLLARSGLPEHCERLTKDDNNLNLKLLDSPSPQLPSTPINPPHQPPSEGILTRTTSIRSTFTAATASTSSQTVPHPHRLTASIPRRLSSQQPIPHLPRRPVPSNPSIPGTGLNSRNGFEPVPLHDEDEDSQASAALVTDGMQMQSHNRQPTAVPNYRSQHHQRSFSHTAPFSQMPMLPEEDYGPSNSMDSRQQYLPPEADAEAQAQQALISDGGMGAGTIDPNLPPYQPSDRRMSGHGAPGESNEMMLSGYIKGQTRAQDMKDSGNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0SB12</accession>
    <name>G0SB12_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0048510</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695214.1">
        <property type="nucleotide sequence ID" value="XM_006695151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SB12"/>
    <dbReference type="GeneID" id="18258889"/>
    <dbReference type="KEGG" id="cthr:CTHT_0048510"/>
    <dbReference type="eggNOG" id="ENOG502S1B6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019843_2_0_1"/>
    <dbReference type="OMA" id="THANHLG"/>
    <dbReference type="OrthoDB" id="5210591at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="499" mass="54492" checksum="16D4005934E71E1F" modified="2011-10-19" version="1">MGEAATVSWITGQVEQRSRGRRLSENQGGKSEGRKRGERETEKQQELKEQQNNQDSKGEQKEQQPEHSTSLQRPRSNDDNPLPALLPTLLYQGPSPSPFPNTAPSSYAIYQPTEGTPISFLPQPLSPQAQTNIDFQLGRLFRHLAQFTSPTGRFGPVPAVLAAQGSPGPRPSSPGAPPTITDSPPGFQLAIPAPGGGSLMSTGGAAAWSTAFHSMLEGVLRDGEDMAVAIPYATIRRHFRRLGYVLDAVREGRLVVVRGGKEGVVLVKKEEEEEEEEGEKGGYKLRGLGDWSSAVFGDVLLATVFSDPLVKEGGVREGFVRGFNGEGLPPSTSASEQGSTTTQFVDLMQTIDPSLVQSPETAPTRILLYQVYHAVSRIVSEFYRPSRAEGSTSSELEARKKLNEVLAKLTKVSDYPLVSPSQPQVQAQELGSQRQAVRVQYPQHHWGEWYPSIQQQQLTLGEGSAKGDKKDTLLRKHRRMSGEMSPAKKVKSDDEDDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G0SB85</accession>
    <name>G0SB85_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sterol 3-beta-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.173</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Autophagy-related protein 26</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CTHT_0049260</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a sterol + UDP-alpha-D-glucose = a sterol 3-beta-D-glucoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22724"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15889"/>
            <dbReference type="ChEBI" id="CHEBI:37424"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.173"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:22725"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ergosterol + UDP-alpha-D-glucose = ergosteryl 3-beta-D-glucoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61836"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16933"/>
            <dbReference type="ChEBI" id="CHEBI:52973"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:61837"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.173" evidence="4"/>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695287.1">
        <property type="nucleotide sequence ID" value="XM_006695224.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0SB85"/>
    <dbReference type="GeneID" id="18258964"/>
    <dbReference type="KEGG" id="cthr:CTHT_0049260"/>
    <dbReference type="eggNOG" id="KOG1192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000537_6_0_1"/>
    <dbReference type="OMA" id="WRNKTLG"/>
    <dbReference type="OrthoDB" id="10261837at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13215">
        <property type="entry name" value="PH-GRAM1_AGT26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13216">
        <property type="entry name" value="PH-GRAM2_AGT26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000303">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000560">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000029">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000009">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048066">
        <property type="entry name" value="ATG26_PH_GRAM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048065">
        <property type="entry name" value="ATG26_PH_GRAM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF25">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="17">
        <location>
            <begin position="361"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="127"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="530"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="791"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1435"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="284"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="542"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="609"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="625"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="642"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="793"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGS19465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1541" mass="171407" checksum="4746F9D66765D603" modified="2011-10-19" version="1">MDSSAQPLCRATASPRPSESKDESKQAHAPLSPSEPTATSAASAAAQDERTARRVSRKLQKRRRDGVHTPSFELPERLRETNDEADSDEEVLRPQAYPGGMFMNMHQSIFGLVAAVGRQANFSDRFESLSSDDEDDESPLAKTIAAPRQPSPWRPDHSSSSTTAMAQTTLLPLTARSSSDQHSSSTDTPTRHRRKISENLLRSVPGLSRFAEKLRPSKSSKEKSAKAPHDDSAADRSISSSKSSSAPPTGLAPAIEITRTEGMGEPIMSKLLEARAQVASRPSFELDRLTEEEGRAEGDDGTIGPSELAKTLKHIFEFERPEEVIQEYPCWLLQHVLLQGYMFITTRHIAFYAYLPKKANEVVKSGYLSKCGKRNPKYNRYWFRLKGVVLSYYRDPQDLYFPSGHIDLRYGISASITDKDKEGINFTIETHNRTYYFRADSAQSAKEWVKCIQRVIFRSHNDGDSVKISLPIENIIDIEETHMLDFAETCKIRVIDNDETYAIDEYYFSFFSYGKDAINLLKILIDDSSSQARDASDGPDKSLAASTRTSMSASRDQAQGRPGRLTEGVKATLSPMTPPRCASPVSRASQDRPRSSFDAFRPFRRSIDVAQSSELHPTSPSRSYSKTRRSFSKHRREALHEQQGSSDSFVQSVGDPSQASLSALVHSASSEDPSASQILRGSEVFHSPIFHRSSNKAEDTEEPVSAGIVRHDTDATVKPSTQQGTARQENAVGATATTPTLQSIANMGGYPFRKANALMGYLDRQSRRMSNLLATESMGYVEKVSGMWKGGGKHYDDPAGLRTDEEDGQEDPNERANSEARFREHFALPETERLQAAYFGYMMRVLPLYGKIYIGDRHFCFRSLLPGTRTKLVLPLRDIENVDKEKGFRFGYSGLVVVIRGHEELFFEFSKAEVRDDCAVTVLQSIEATRFLPDSSLLDGADSEDAQAAVAERDALQEARNEEFGDHELQLPRQASSVTEAPTILFDDSATSFLSFKPAQSMTITCLTIGSRGDVQPYIALCKKLLEEGHRPRIATHLEFKDWIESHGIEFAYVGGDPGELMRLCIQNGTFTWQFLKEANAKFRGFLDDLLATSWEACQGSDLIIESPSAMAGIHIAEALEIPYFRAFTMPWTRTRAYPHAFVMPGQKMGGAYNYLTYVMFDTVFWKTTAHQINKWRNNMLGLPSTNLEKLQVNKVPFLYNFSAYVVPPPLDYSDWIRVTGYWFLDEGDNNSKWTPPPELRAFIEKARSDGKKLVYVGFGSIIVPDRIKMTQDVIDAVLKADVRCILSKGWSDRSKNPDQQEQEPELPPEIFQIQSAPHDWLFRQIDAAAHHGGSGTTGASLRAGIPTIIRPFFGDQFFFGSRVEDLGVGICLKKWGANSFARALWEATHSERMIVKARVLGEQIRKENGVETAVQCIYRDLEYATNLIKAKARKNPSRRNTISSGTGEPLPAPANATASNGAEAGVGLGLELGTGGDGPSIDFDDEEESWTFVDRFDDHWDYQPQHHQHGFLRNPALTAPASAAKSLGSKVLGGAVGGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBB8</accession>
    <name>G0SBB8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0049660</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695320.1">
        <property type="nucleotide sequence ID" value="XM_006695257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBB8"/>
    <dbReference type="GeneID" id="18259004"/>
    <dbReference type="KEGG" id="cthr:CTHT_0049660"/>
    <dbReference type="eggNOG" id="ENOG502RJ1I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_397392_0_0_1"/>
    <dbReference type="OrthoDB" id="4587880at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="674"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="693" mass="71804" checksum="D901AA32B81A6643" modified="2011-10-19" version="1">MNDSSPPSSGPPNDPSQSICFNAALGLSVPAASAGNGTTQSQPAPATNAGNTVPVDPTLEQMADAVLSTATPTHRSAVGPSNGMTAAPTHSQDRGLLLSPARIVPAALRSAATGPSVIRGLPSRPASQSSPANRVLAPSPRGRDAAPATPLDPISCSSSFTSGLAANVGINGNGVMNATSASSPVVSSGLRFSSPDPFVGPSHHTTKNKNENLFVLGSSFFSSSSALAGPLFSPASTLSGSAAATVGSSLTGFASSPPASLSFDFTASGTFPGSATTGFAAISSAAGLGSATAATCGISSRAMVLSSAPDHSAVSRLGLGSGATFGSSAAGSPAGPSTLATPATDEDDNNSDHNNEKMESGDDEADEVNEMNNNIKIDKGKGKAVDYGDINDDANSNSSLEMSNAAAVPHQINIPEDKMYDWEANPISAFWIRNNPHPSPHQSLSLKDFYSGLIPPFPTDPALPFAPWRVHDLPPFRPEPIHRAVQVPLRFLASIGQLYPRAVFAVSRLPIHALTQSPQVMSGEMLAKSALMHFAVGGATAGLDAFATEWDHAVYGVVLLRRDWPTGGVAALPNDNGTTQFFEGVKSAFGVLPFGLEKWNYLVHRETMWDGTVRWGVLVCRGYEGVQGPQSNAVLRRWCEEKAHGFGANLQAKRVLEHMFGVVPTFGMVMQDLGGKQDSEGGKKGVERKRNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBK1</accession>
    <name>G0SBK1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CTHT_0053860</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="814" last="814">
            <title>Structural and functional insights underlying recognition of histidine phosphotransfer protein in fungal phosphorelay systems.</title>
            <authorList>
                <person name="Paredes-Martinez F."/>
                <person name="Eixeres L."/>
                <person name="Zamora-Caballero S."/>
                <person name="Casino P."/>
            </authorList>
            <dbReference type="PubMed" id="38965424"/>
            <dbReference type="DOI" id="10.1038/s42003-024-06459-0"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 1085-1220 IN COMPLEX WITH MG(2+)</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695722.1">
        <property type="nucleotide sequence ID" value="XM_006695659.1"/>
    </dbReference>
    <dbReference type="PDB" id="8PHN">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.90 A"/>
        <property type="chains" value="A=1085-1220"/>
    </dbReference>
    <dbReference type="SMR" id="G0SBK1"/>
    <dbReference type="STRING" id="759272.G0SBK1"/>
    <dbReference type="GeneID" id="18259424"/>
    <dbReference type="KEGG" id="cthr:CTHT_0053860"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_3_2_1"/>
    <dbReference type="OMA" id="CLAAQMD"/>
    <dbReference type="OrthoDB" id="10266508at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06225">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000002">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1530:FF:000001">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1530:FF:000002">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000015">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1530">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18947">
        <property type="entry name" value="HAMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58104">
        <property type="entry name" value="Methyl-accepting chemotaxis protein (MCP) signaling domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="19" id="KW-0002">3D-structure</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409030" description="histidine kinase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="16">
        <location>
            <begin position="162"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="16">
        <location>
            <begin position="257"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="16">
        <location>
            <begin position="349"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="16">
        <location>
            <begin position="441"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="16">
        <location>
            <begin position="533"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="16">
        <location>
            <begin position="625"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="14">
        <location>
            <begin position="699"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="15">
        <location>
            <begin position="1100"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="77"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="1105"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="1106"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="1149"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="1151"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="10">
        <location>
            <position position="1149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGS18777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="19">
        <source>
            <dbReference type="PDB" id="8PHN"/>
        </source>
    </evidence>
    <sequence length="1321" mass="143505" checksum="CAFB8B4BF9371272" modified="2011-10-19" version="1">MSGNHSLAAVLAIVKAIAADPKTPSPLFSACPTPFQIPGPLSPEKAELERELAALACRVQQLEAKVYHYSTTTIFPQTPEGSNGSPILTDAHSMSRPELTGSSPNTSGRGCIDGAIAGLEQHANALRRAGEGDEAEMTAALKEKERIATLERELRKHQQANIAFQKALREIGEIVTAVARGDLSKRVLMNTGDMDPDITTFKRTINTMMDQLQVFSSEVSRVAREVGTEGILGGQARIEGVAGTWKELTDNVNIMAQNLTDQVREIASVTTAVAHGDLTKKIERPAKGEILQLQQTINTMVDQLRTFASEVTRVARDVGTEGMLGGQADVEGVQGMWNELTVNVNAMANNLTTQVRDIIKVTTAVAKGDLTQKVQAECRGEIFELKKTINSMVDQLQQFAREVTKIAREVGTEGRLGGQATVHDVQGVWRDLTENVNCMAMNLTTQVREIAKVTTAVARGDLTKKIGVEAKGEILDLKNTINTMVDRLGTFAFEVSKVAREVGTDGTLGGQAQVENVEGKWKDLTENVNTMARNLTSQVRNISIVTQAIANGDMSQKIEVEAKGEILVLKETINNMVDRLSIFCNEVQRVAKDVGVDGIMGGQADVAGLKGRWKEITTDVNTMANNLTAQVRAFGDITNAATDGDFTKLVEVEAAGEMDELKKKINQMVCNLRDSIQRNTQAREAAELANKTKSEFLANMSHEIRTPMNGIIGMTQLTLDTDLTQYQREMLNIVNSLANSLLTIIDDILDLSKIEARRMVIEEIPYTLRGTVFNALKTLAVKANEKYLDLTYRVDSSVPDYVVGDSFRLRQIILNLVGNAIKFTEHGEVSLTIQKASQAHCRPNEYAIEFIVADTGIGIPEDKLDLIFDTFQQADGSMTRKFGGTGLGLSISKRLVNLMGGDVWVKSEYGKGSQFFFTCVVKLADDNVSLISKQLTPFKGHQVLFIDKGRTRYGPEVVEMLRGLGLVPVVVNSERNAVLSKNKTANCCGNAEDAAVTSKQFTAKKKTGSGSQGKAVSSFDVIIVDSIEDARRLRAVDDFKYLPIVLLAPVVHVSLKSCLDLGITSCMTMPCKLIDLGNGMLPALENRATPSLADNTRSFEILLAEDNAVNQRLAVKILEKYHHVVTVVGNGEEAVEAVKRKKFDVILMDVQMPVMGGFEATAKIREYEASLPTPQRTPIIALTAHAMMGDREKCLEAQMDEYLSKPLQQANLIQTILKCATLGGQLLEKNQSQYRDRRELELARRAADAATGGRMGGVNGMGLGMGLMGLGTGGCASPVGTASGRLLPVCQGSSITASTVTLPTPEAEDAVMVNKPVEEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBK8</accession>
    <name>G0SBK8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative transcriptional activator hap3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0053940</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NFYB/HAP3 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695729.1">
        <property type="nucleotide sequence ID" value="XM_006695666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBK8"/>
    <dbReference type="STRING" id="759272.G0SBK8"/>
    <dbReference type="GeneID" id="18259432"/>
    <dbReference type="KEGG" id="cthr:CTHT_0053940"/>
    <dbReference type="eggNOG" id="KOG0869">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066247_10_0_1"/>
    <dbReference type="OMA" id="ADPNYMY"/>
    <dbReference type="OrthoDB" id="386949at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22907">
        <property type="entry name" value="HFD_NFYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000110">
        <property type="entry name" value="Nuclear factor Y, subunit B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027113">
        <property type="entry name" value="Transc_fact_NFYB/HAP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003956">
        <property type="entry name" value="Transcrpt_fac_NFYB/HAP3_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064">
        <property type="entry name" value="CCAAT-BINDING TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064:SF9">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00615">
        <property type="entry name" value="CCAATSUBUNTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00685">
        <property type="entry name" value="NFYB_HAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="9">
        <location>
            <begin position="50"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="138"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS18784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="203" mass="22511" checksum="DE247812FF525C2D" modified="2011-10-19" version="1">MSDSPQSNNPKDVEQSAPSGDDEAQMNDPQDPHSSGLTYESGFEVKEQDRWLPIANVARIMKNALPENAKIAKEAKECMQECVSEFISFITSEASEKCHQEKRKTVNGEDILFAMNSLGFENYAEALKIYLTKYREQQSQSNRGENAQNRPNNQNYNATGASNTTTAPGGFNNAQLQEQQTGGDPNNYGLYGQPDHNGTTTNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBL8</accession>
    <name>G0SBL8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Actin-related protein 2/3 complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0054040</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
            <location evidence="7">Cytoskeleton</location>
            <location evidence="7">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the WD repeat ARPC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695739.1">
        <property type="nucleotide sequence ID" value="XM_006695676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBL8"/>
    <dbReference type="STRING" id="759272.G0SBL8"/>
    <dbReference type="GeneID" id="18259442"/>
    <dbReference type="KEGG" id="cthr:CTHT_0054040"/>
    <dbReference type="eggNOG" id="KOG1523">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034396_1_1_1"/>
    <dbReference type="OMA" id="YVWEPSP"/>
    <dbReference type="OrthoDB" id="406844at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000220">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017383">
        <property type="entry name" value="ARPC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709:SF2">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038093">
        <property type="entry name" value="ARP2/3_su1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS18794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="357" mass="39531" checksum="1A8724FF31D41F5A" modified="2011-10-19" version="1">MAAPEVHHLFHAPIADHSFSADRNTVAVARDTSVEIYKRVANSFKLKDELKGHDKTVTSVDIAPNSGHRNALVWEPTAQGYKPTLVLLRINRAATFARWSPNETKFAVGSGDRLIAICYFEQENDWWVSKHLKKPIRSTVTTVAWHPNSVLLAAGSTDAHARVFSAFIKGVDSKPEPTAWGERLPFNTVCGEFMNNSAGWIHSVAFSPSGNALAYAAHDSSITVVYPSAPEQPPRAVITVNTHLLPFMSLIWNGEDEIIAAGYDCEAFRFRGGEDGWQLTGAVEAKGRPDQDADQREESALQMFRQMDLRGKVKDDTQLKTVHQNTITHLRPYETSGGYLTKFSSSGVDGRIVIWTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBR6</accession>
    <name>G0SBR6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="13">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CTHT_0054520</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:21249"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="13"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695787.1">
        <property type="nucleotide sequence ID" value="XM_006695724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBR6"/>
    <dbReference type="STRING" id="759272.G0SBR6"/>
    <dbReference type="GeneID" id="18259490"/>
    <dbReference type="KEGG" id="cthr:CTHT_0054520"/>
    <dbReference type="eggNOG" id="KOG0216">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000524_5_1_1"/>
    <dbReference type="OMA" id="FFGVVHY"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.150:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1070.20:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000007">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009674">
        <property type="entry name" value="Rpa2_dom_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06883">
        <property type="entry name" value="RNA_pol_Rpa2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="18">
        <location>
            <begin position="39"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="202"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="19">
        <location>
            <begin position="489"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase I subunit RPA2" evidence="20">
        <location>
            <begin position="594"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="15">
        <location>
            <begin position="701"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="16">
        <location>
            <begin position="1079"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1214"/>
            <end position="1235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF06883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EGS18842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1235" mass="138932" checksum="00CC354C02273F4D" modified="2011-10-19" version="1">MAPEPTSTEWDHEYNTIRREKLFRNPPTDRTAYPALQEAVNPHIESFNALFRTDGKPSLLDHAIAEIGTKTFLDGDERAAPEGKNKLTIRYKSITLQKSQVPPSNKWAKRREIFPAECRERHVTYRGKLTATFEYRINDGEPQEFVRELGQMPIMVKSNKCHLENNPPALLVQRKEESEELGGYFIINGIEKIIRMLLVNRRNFPLAIIRPSFTNRGPSYTQYGIIVRSVRPDETSQTNVLHYLSDGNVTFRFSWRKNEYLVPVMMILKALVETNDREIFEGLVGPPNSKGIENTFLTDRVELLLRTYKKYGLYTKSQTRAYLGSKFRVVLGVPDTMSDYEVGTEFLRKIVLVHLGCVNVTEEQDLDKFKMLLFMCRKLYALVAGDCAVDNPDAVQNQEILLGGFLYGMILKERLEELLSVSLRAALRDYLRRNPTISFTSQTFQKDFPIAIFRRTNENIGNALEYFLSTGNLQSPSGLDLQQVSGFTVVAEKLNFWRFISHFRMVHRGSFFAQLKTTTVRKLLPESWGFLCPVHTPDGAPCGLLNHLAHKCKIMTDTLDTSAVPGAVMELGVNDYSSAATSESVVVMLDGRIIGWCTPKASRIIAETLRRWKVEGNHGIPLQLEIGYVPPSKGGSYPGIYMASKPARMVRPVKYLALAKEDFVGPHEQPYMSIACTPEEIIPGDHTHVEYDPTNILSILANMTPFSDFNQSPRNMYQCQMGKQTMGTPGAAIKYRTDNKMYRLQTGQTPIVRSPLHNVYGFDNFPNGTNAVVAVISYTGYDMDDAMIINKSAHERGFGHGTIYKTKKISLKDDTRTRTSKTITKMFGFAPGTPIRPEYREMLDEDGLPHVGRLVREGDILCAWHTVSADYSGKLVNKDGITHWERYKDAEDAFVEEVRVIGSETGNEPLQTVSIKLRIPRSPVIGDKFSSRHGQKGVCSQKWPAIDMPFSESGIQPDVIINPHAFPSRMTIGMFVESLAGKAGALHGLAQDSTPFRFDEEHTAADYFGHQLMKAGFNYHGNEPMYSGITGEEFACDIYIGVVYYQRLRHMVNDKYQVRTTGPVVPTTGQPIKGRKKGGGIRVGEMERDALLAHGTAFLLQDRLLNCSDYSRSWICRDCGSFLAVQPTVSPFIGKRKQVGTVRCRNCAKRLDQIEDLDLMKLEGEIWEDGQGVQWIGGENTTMVVVPGALKFLDVELAAMGVKLKYRVDNKDAIRRGPMKPAPPKALLNGSTVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0SC00</accession>
    <name>G0SC00_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0055390</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695871.1">
        <property type="nucleotide sequence ID" value="XM_006695808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SC00"/>
    <dbReference type="STRING" id="759272.G0SC00"/>
    <dbReference type="GeneID" id="18259577"/>
    <dbReference type="KEGG" id="cthr:CTHT_0055390"/>
    <dbReference type="eggNOG" id="ENOG502RX7Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019313_1_0_1"/>
    <dbReference type="OMA" id="RSQSGCY"/>
    <dbReference type="OrthoDB" id="5213892at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF20">
        <property type="entry name" value="PRO1A C6 ZINK-FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="98"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS18926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="653" mass="72512" checksum="3A06C6F9AA9A0411" modified="2011-10-19" version="1">MTVAGLMATKPRSFGGCWTCRLRRKKCDETRPICGACSTLEIECQYGDEKPEWMDGGERQKRRAEWLKAEVKRRAAHRRERRQLHGLEVRLESLDASLTDESDSTVPRDLINTTARPVAPSMDASSSSSPYIKTESSSASSPSVRTPHSRSATPHTDSCSSVPTPEDLSDSHAESSLEAAFSLEIEAHSIMLYLDYVFPFLFPFYKPPFFDAGRGWLLVLLTKNKALFHSAVSLSGYFYGIILSHTSQGHQHCTKNTHEALHKQQGLALQWLQREMQDIITRGVKSNLVEANRVMASIVQLLTSEVAIGTPGNWKMHLGAATELFNEIMKHHAVTPSGFPCFMSVLLRLGTRPFEWTPKNRPWGSDQATLRFFTAQLLFYDTIASTALGQPPRLQQWHQPLLEELPDEIKQLLPGNERETISPHINLEEFAGVQNWVILCIGQIASLDAWKKEMKRAGSFSVPQLFSRASTIEQRLRTCLESLSDCQAVNGSCPASSINGCSQSQPFLPYFASDAGSPFSRTLHTSVLNTRIWAQAALTYLSVVLSGFQPSSPEICESVSATIEMLLSLPNPECLRTLVWPFTVTGCLASPEQEHVFRNLVSAMGPLSVLGTVREGLAILEKVWARRREIEQAPDGWDLAACLGTLGQPALLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0SC40</accession>
    <name>G0SC40_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0055830</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695911.1">
        <property type="nucleotide sequence ID" value="XM_006695848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SC40"/>
    <dbReference type="STRING" id="759272.G0SC40"/>
    <dbReference type="GeneID" id="18259621"/>
    <dbReference type="KEGG" id="cthr:CTHT_0055830"/>
    <dbReference type="eggNOG" id="KOG1364">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021255_2_0_1"/>
    <dbReference type="OMA" id="PAIFDCQ"/>
    <dbReference type="OrthoDB" id="270602at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02958">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF6">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13899">
        <property type="entry name" value="Thioredoxin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="437"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS18966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="523" mass="59087" checksum="ED7DCA940010BEF9" modified="2011-10-19" version="1">MAVAEKMLDMCGDLEQAVQLWFADEDLQRTVSADTGSSIAAVSGTTSQHGRLNRSRIGREDEHGVIHIDSDDDAPMTEVDSGDDTAEAANIARKAQEEEDAAMAKRLQEELYSAQVVEDNVRAPIARRTETLIGPDYGEDDPHSLMLEQFRRRQHQARIRNNNPFAQSPWGDNYSGSGSASGAENSRASRLAELFRPPYELISRLSWDEARDTGKEEKKWLLVNLQDMSDFNCQALNRDIWKDNAVKSLVRENFIFLQYEKNDFEAERYITYYFQNDAHHNPNNYPHVSIIDPRTGEQVKVWSGRPFPTALEFHSQLVEFLDRYSLDVYSKNPVSKIKRSERTVDLDRMTEEEMLEMALKNSLEPNGGSANRSTVIDPDALTKSSSDLSNAKGKERATSESSSEPSTPESEEEQQSQQASPWARIPSDRPHTEPSADPKTTTRIQVRNPAGRIIRRFLLDDPVSRIYEWIKADQANLFPGKEGVVFELKAMPQGVDLIEKLNETIKDAGLANGTVMLEFVEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCR0</accession>
    <name>G0SCR0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0058110</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696131.1">
        <property type="nucleotide sequence ID" value="XM_006696068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCR0"/>
    <dbReference type="GeneID" id="18259849"/>
    <dbReference type="KEGG" id="cthr:CTHT_0058110"/>
    <dbReference type="eggNOG" id="ENOG502S04M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035511_1_0_1"/>
    <dbReference type="OMA" id="FAASRIW"/>
    <dbReference type="OrthoDB" id="2392789at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046921">
        <property type="term" value="F:alpha-(1-&gt;6)-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13132">
        <property type="entry name" value="ALPHA- 1,6 -FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13132:SF29">
        <property type="entry name" value="ALPHA-(1,6)-FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS19186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="413" mass="45703" checksum="144A2BF1CA8AF372" modified="2011-10-19" version="1">MDCVDTPWNGVPTVYQPEAQRAGYLPRGSISTATGGKQVCKKSLTFVLESDDAGLGKTLLMLWIAYGLARKEDRAFFIDDTRWAYGNYTDIFLPPPLPDCAAPPAHEILPCPRQARHLVVSAETADEFFRGILKNNSQPWSDSRNHQSRKEQFDLARQGYEALFRLNSADSEYVASRLHELTSAKKLVSTIAVGIHVRRGDRHPLEFEYRRSYIPLYAYADAAGEIIMQRNRGTTPATGFLILSSDDPAVYASEELRGAIPAQDRIRLGLRETLHTADVVQRDKSVIYKFVDQDDISNDDALSPFAASRIWHGGFFSDTFWNLGLPANAHAHVHAHSYGHSHSHGYAQIPVTANGQAPAKRLPVDATRSSKDVDTIITDSTPRALHLRSIVGRAYVMDLAVLAGASDDIVCAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCR8</accession>
    <name>G0SCR8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0058190</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696139.1">
        <property type="nucleotide sequence ID" value="XM_006696076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCR8"/>
    <dbReference type="GeneID" id="18259857"/>
    <dbReference type="KEGG" id="cthr:CTHT_0058190"/>
    <dbReference type="eggNOG" id="KOG0379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019536_3_0_1"/>
    <dbReference type="OMA" id="TMTWDRR"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF3">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="84"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="162"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="201"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS19194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="598" mass="63756" checksum="893ABC2BE11F268C" modified="2011-10-19" version="1">MADQARAAARDRPPQSSQDLRARNTPMTSPADMRPPPSSDLCDSAESSDRATPIPRSHTPGHLSSKSQDRRPTDKPIEIAIRQRSQSSAAASSISSSSTIVPSASSSTTSFTIAASASSSRSLNNPSSSRLPSTSTSTYENDDSRETQDSSAANSNRDALNGSGAATTSTSSAPRRPTALRSTSAIAGRPAPGGGAGTGTTGTSSGSGTAINTSSNDTNKSRTSNSTSGASRMRGMPAKGAETYTPCPPLIDPKTAPNVPEAPSSGMYWTKAMTSGHPHTALRAHTATIVGSNVYVFGGCDSRACFNELYVLDADSFYWSRPHVVGDIPVPLRAMTCTAVGKKLVVFGGGDGPAYYNDVYVLDTVNFRWYKPKIVGDKVPSKRRAHTACLYKNGIYVFGGGDGVRALNDIWRLDVSDMNTMSWRLISGSSSSSLTANGRSGGVAKEIRPKARGYHTANMVGSKLIIYGGSDGGECFNDVWVYDVETQIWKQVNIPITYRRLSHTATLIGSYLFVIGGHDGNEYSNEVLLLNLVTMTWDRRKVYGLPPSGRGYHGTVLHDSRLLVIGGFDGTEVFGDVWILELAVHSYYSQISHFTIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCS2</accession>
    <name>G0SCS2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multiple RNA-binding domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0058230</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-rRNA processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM MRD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696143.1">
        <property type="nucleotide sequence ID" value="XM_006696080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCS2"/>
    <dbReference type="STRING" id="759272.G0SCS2"/>
    <dbReference type="GeneID" id="18259861"/>
    <dbReference type="KEGG" id="cthr:CTHT_0058230"/>
    <dbReference type="eggNOG" id="KOG0110">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008479_0_0_1"/>
    <dbReference type="OMA" id="FNNTCIQ"/>
    <dbReference type="OrthoDB" id="439639at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12568">
        <property type="entry name" value="RRM3_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12320">
        <property type="entry name" value="RRM6_RBM19_RRM5_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000247">
        <property type="entry name" value="Multiple RNA-binding domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000452">
        <property type="entry name" value="Multiple RNA-binding domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034482">
        <property type="entry name" value="Mrd1_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="4"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="310"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="491"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="603"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="708"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="82"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS19198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="832" mass="91376" checksum="1707EE3F046A26F9" modified="2011-10-19" version="1">MQSSRIFVKNLPPNITESDFRKHFAVQGRQVTDVKLYPSRRIGFIGYKSAEDAAWAVKYFNKTFIRLSRIAVDLAKPIADSIPKNGAKLTPANGSARISLHNAPASGIGQAEDGNSKKRKREEPAEEADPKLREFLEVMGHTSKKLRDQDVPSAEPQSEPVATVAGGESDDEYDDVAVRKKSQSDNTVGHSMPSAARAVTAELPIGAPPPEELKVPVPPPVPADTTDDDWLRSRTNRLLDLVDPDDPQFPIRPVSSMPAAATALKAEEHPPGENAVLLKPDKAGDASVKDKAAEQHGSMEDAIATINKTRRLFLRNLSYTTTEDDLREHFSRFGALEEVNLPLDNQNRSKGFAMIRFEKPEAAVAAFQLDGSTFQGRLLHILPAAPKREFKLDEFALSKLPLKKQLLLKKKAEAASSTFNWNSLFMSQDAVNTAVAERLGISKHELLDPTDASAAVKQAIAETSVIQEAKTYFAKHGVNIEAFKNQQRGDTVILVKNIKNTTAEELRDLFAEHGSVLRVLMPPSGTIAIVQFAQPAACRAAFAKKAYSRFKDSVLFLEKGPKGLFTDTPPLQQGNQTTGVQKLSAAELLARDDAEEESTVETSSLYVRNLNFSTTSEGLANAFKHLDGFVSATVKTKPDPKKPGQVLSMGFGFCVFRTKEQAQAALKAMDGTVLDGYKLVIKASHRGLDAAEERRREDLAKKAAVVKRKIVIKNLPFQATKKDIRDLFGTYGKLVAVRVPKKFNSQSRGFAFAEFATAKEALNALTALKDTHLLGRRLVLDFAEADEVDPEEQIKAMEKKTRDQLNKVTLQQLTGGGRKKINIGGDHDEDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCS7</accession>
    <name>G0SCS7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0058280</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696148.1">
        <property type="nucleotide sequence ID" value="XM_006696085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCS7"/>
    <dbReference type="STRING" id="759272.G0SCS7"/>
    <dbReference type="GeneID" id="18259866"/>
    <dbReference type="KEGG" id="cthr:CTHT_0058280"/>
    <dbReference type="eggNOG" id="KOG3497">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143122_2_1_1"/>
    <dbReference type="OMA" id="YCCRRMF"/>
    <dbReference type="OrthoDB" id="10258858at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000024">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00250">
        <property type="entry name" value="RNApol_arch_Rpo10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023580">
        <property type="entry name" value="RNA_pol_su_RPB10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020789">
        <property type="entry name" value="RNA_pol_suN_Zn-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000268">
        <property type="entry name" value="RPABC5/Rpb10"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003089">
        <property type="entry name" value="PRK04016.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431:SF3">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01194">
        <property type="entry name" value="RNA_pol_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46924">
        <property type="entry name" value="RNA polymerase subunit RPB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01112">
        <property type="entry name" value="RNA_POL_N_8KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS19203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="89" mass="10289" checksum="84813233AD1D0C0F" modified="2011-10-19" version="1">MIIPIRCFSCGKVTGDLWEKFVKLIEEEGLSDGDALDQLGCKRYCCRRMVMTHVDLIEKLLKYTPDGRNYKKIQMQIRAQEESQTASQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCU6</accession>
    <name>G0SCU6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0058470</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696167.1">
        <property type="nucleotide sequence ID" value="XM_006696104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCU6"/>
    <dbReference type="GeneID" id="18259885"/>
    <dbReference type="KEGG" id="cthr:CTHT_0058470"/>
    <dbReference type="eggNOG" id="ENOG502SFQR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146832_0_0_1"/>
    <dbReference type="OrthoDB" id="5226533at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="149" mass="16714" checksum="813454DB6073EC83" modified="2011-10-19" version="1">MLSLTATEEIRALTEQLRQTNIPPTASELLRLSEQLRALSDQLRELSEQARATAATASSRRPSMFLELAPSTSDSYPRPPRVDYRAPTQAQPHPVQNSIQSVKRRTSSLSSEDSSTASRARLRFLKLNPVHWGEHLDDHKGDFHDVAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0SD40</accession>
    <name>G0SD40_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="15">PARP</shortName>
            <ecNumber evidence="15">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CTHT_0050720</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H(+).</text>
            <dbReference type="EC" id="2.4.2.30"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the ARTD/PARP family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="15"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695415.1">
        <property type="nucleotide sequence ID" value="XM_006695352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SD40"/>
    <dbReference type="STRING" id="759272.G0SD40"/>
    <dbReference type="GeneID" id="18259110"/>
    <dbReference type="KEGG" id="cthr:CTHT_0050720"/>
    <dbReference type="eggNOG" id="KOG1037">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004841_2_0_1"/>
    <dbReference type="OMA" id="QGENDRF"/>
    <dbReference type="OrthoDB" id="2017365at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070212">
        <property type="term" value="P:protein poly-ADP-ribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01437">
        <property type="entry name" value="parp_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07997">
        <property type="entry name" value="WGR_PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.142.10:FF:000002">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.140.10:FF:000001">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.228.10:FF:000002">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.142.10">
        <property type="entry name" value="Poly(ADP-ribose) polymerase, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.140.10">
        <property type="entry name" value="WGR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050800">
        <property type="entry name" value="ARTD/PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004102">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036616">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036930">
        <property type="entry name" value="WGR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008893">
        <property type="entry name" value="WGR_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459">
        <property type="entry name" value="DNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459:SF60">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02877">
        <property type="entry name" value="PARP_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05406">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00773">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47587">
        <property type="entry name" value="Domain of poly(ADP-ribose) polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142921">
        <property type="entry name" value="WGR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51060">
        <property type="entry name" value="PARP_ALPHA_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51977">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0013">ADP-ribosylation</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 15" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BRCT" evidence="17">
        <location>
            <begin position="11"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="WGR" evidence="20">
        <location>
            <begin position="227"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="PARP alpha-helical" evidence="19">
        <location>
            <begin position="357"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="18">
        <location>
            <begin position="492"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="109"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="167"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EGS18470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="725" mass="80543" checksum="215C41FFBB67FDE6" modified="2011-10-19" version="1">MPPKRGKKGAPQPPPLEGCKLAFSGAFRVVSQAALKAKAEALGATVSNTVTNDTTHLIATEAHYNKREPKVMQAISLGIPVVSMEWLTTCEKNSAKPTEKDYVPGVVIPAQNGTSAQPVAQDSQADGSDTAATKSRKRSSDDANISDDKDTAAPKTKRTRGKNAAAKVEKADMKNEDVEMKDADNAAGADSEKKNEKVKAEKAVGEGQIAKSKDLKVPLDEGCPYITSKVYIDDDGVIYDVSLNKTDASKNNNKFYRIQVLVDPSGTFRTWTRWGRVGERGQTQVAAEGTKENALKQFEKKFKDKSGLAWSQRGENPKPGKYAFVERNYEDDSDEEYEAKVKKEGNGNGKIAREPPKCTLHPAVQRLMELIFNAQYFAATMASLNYDSNKLPLGKLSKATISRGFQVLKDLSNLIDDPSLASNYGQPFPQAIEQLSNSFYSIIPHAFGRNRPPVIRDRQMIKKEVELLESLSDMKDADLLMKLEKTVEDDIHPLERQYRGLNMKEMTPLDPTSEEFIQLQNYLNESRGVTHGHSYRIEEIFRIERQGEHERFDNSLFGKMKKNRRLLWHGSRVTNFGGILSQGLRIAPPEAPSTGYMFDKGIYLADMSSKSANYCHSYLSGGTALLLLCEAELGDPMQEFINAAYNAATTAKQKGMIATWGKGRTGPLKWKSAACVHPSLEGVMMPDTSVPPGDTKVKDASLWYNEYICYDVAQVRLRYLFRIRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>G0SD47</accession>
    <name>G0SD47_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0050790</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695422.1">
        <property type="nucleotide sequence ID" value="XM_006695359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SD47"/>
    <dbReference type="GeneID" id="18259117"/>
    <dbReference type="KEGG" id="cthr:CTHT_0050790"/>
    <dbReference type="HOGENOM" id="CLU_2003659_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="14550" checksum="7D756180C71BBE58" modified="2011-10-19" version="1">MSFISRHELLSIALRVVQLIFAVIVVVLNGIYLHYFDSPYYHAHFSEVFRSGYAVFIGSVSILLIIGMAVFHQMNRRLAIFGSWIVDLIVGINWFIVFGMFLGAHEAYEETCGFYILRRYYRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>G0SD65</accession>
    <name>G0SD65_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-type Cu(+) transporter</fullName>
            <ecNumber evidence="3">7.2.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Cu(2+)-ATPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CTHT_0059110</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.8" evidence="3"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696230.1">
        <property type="nucleotide sequence ID" value="XM_006696167.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0SD65"/>
    <dbReference type="GeneID" id="18259949"/>
    <dbReference type="KEGG" id="cthr:CTHT_0059110"/>
    <dbReference type="eggNOG" id="KOG0207">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3789">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_0_1_1"/>
    <dbReference type="OMA" id="HWMLPAW"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140581">
        <property type="term" value="F:P-type monovalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd02094">
        <property type="entry name" value="P-type_ATPase_Cu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000001">
        <property type="entry name" value="ATPase copper transporting beta"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000002">
        <property type="entry name" value="Copper-transporting ATPase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000137">
        <property type="entry name" value="Heavy metal translocatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009348">
        <property type="entry name" value="NPR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00003">
        <property type="entry name" value="copper ion binding protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF8">
        <property type="entry name" value="P-TYPE CU(+) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06218">
        <property type="entry name" value="NPR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00942">
        <property type="entry name" value="CUATPASEI"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-0187">Copper transport</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="363"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="400"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="438"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="648"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="690"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1038"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="19">
        <location>
            <begin position="2"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="19">
        <location>
            <begin position="97"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="19">
        <location>
            <begin position="189"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="19">
        <location>
            <begin position="270"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1257"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1262"/>
            <end position="1295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00080126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGS19285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1295" mass="138345" checksum="DD75EBDBFAF3ADA7" modified="2011-10-19" version="1">MATTTLKVEGMTCGACTSAVEAGFKGVDGVGSVSVSLVMERAVVMHDPNKISADRIREIIEDRGFDAEVLSTDLPSPAMPRQSFGAFPTTDNEPNTLVTTVSIKGMTCGACTSAVEGGFKDVSGVKHFSISLLSERAVIEHDPKLLTPQAICEIIEERGFDAEIVESTAKSSEAGANAADGAQIGTMAATTTVAIEGMTCGACTSAVEEGFKKVDGMLRFNISLLAERAVITHDPAKLSAEKIVEIIEDRGFDAKILSTTFESAGITSGSSTAQFKIYGNLDAATATALEEKIMELPGVTSARLALSSSRLTVVHKPHVTGLRAIVEAVESAGYNALVADNEDNTAQIESLAKTRESNEWRQAFKISLAFAVPVFLISMVFPMCLRALDFGSVRLMPGLYLGDVICLFLTIPVQFGIGKRFYKSAWKSVKHGSPTMDVLVVLGTSCAFFFSVFAMAVSLLFPPHTRPSTLFDTSTMLITFISLGRFLENRAKGQTSKALSRLMSLAPSMATIYADPIAAEKAAEAWNSDAKDEAKQPLDGNAMEEKVIPTELIQVGDIVILRPGDKIPADGVVVRGETYVDESMVTGEAMPVQKSKGSLVIGGTVNGHGRVDFRVTRAGRDTQLSQIVKLVQDAQTNRAPIQRLADTLAGYFVPTILTLGLLTFLVWMVLSHVLPNPPEIFLKETSGGKLMVCIKLCISVIVFACPCALGLATPTAVMVGTGVGAENGILVKGGAVLETTTKITHVVFDKTGTITYGKMSVAKANIPSPWKDTDWRRRLWWTIVGLAEMGSEHPIGKAVLNAAKSELGLGPEGTIDGSIGDFSAVVGKGVSAHVEPATSAERTRYKVLIGNIPFLQKNGVSVPEPAIEISEKADATQSDPKLNAGITNIFVAINGIYAGHLCLSDTIKSGAAAAIAVLHRMGVKTAMVTGDQRGTAVAVASAVGIDPADVHAGVSPDQKQAIIRRLQQEHGAIVAMVGDGINDSPALATADVGIAMSSGTDVAMEAADVVLMRPDHLMDVAAALHLARTIFRRIKMNLAWACMYNAVGLPFAMGVFLPLGWHMHPMMAGAAMAASSVDGGGRGEGVVVKGEGWFAGWREMFERVMGRRKREEGAVSHSLDSSRHHPISPINITTMIQGIFYAQFFPNAGTKIVAQSPPGCIVPSEGSTKPTLFNFDVLAEYIIPRNPFCNRYITVDDPEGKYTVLSYPVSISNSKYCRNTFYFNFGIVVESDVDQAPYENVVRRIAATFAEMEKQSGYLSQDLERDEKGNEKGEGDEKGNEKEERDEKGDKRGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G0SD78</accession>
    <name>G0SD78_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">thioredoxin-disulfide reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0059240</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="3"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696243.1">
        <property type="nucleotide sequence ID" value="XM_006696180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SD78"/>
    <dbReference type="STRING" id="759272.G0SD78"/>
    <dbReference type="GeneID" id="18259962"/>
    <dbReference type="KEGG" id="cthr:CTHT_0059240"/>
    <dbReference type="eggNOG" id="KOG0404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024707_0_0_1"/>
    <dbReference type="OMA" id="NGLMSHL"/>
    <dbReference type="OrthoDB" id="10257049at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08241">
        <property type="entry name" value="QOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000064">
        <property type="entry name" value="Thioredoxin reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="10">
        <location>
            <begin position="12"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS19298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="694" mass="74464" checksum="8CA43770C1178E8A" modified="2011-10-19" version="1">MRGIQIKEYVKGPHELKVTDLPDPVPKDDEYLIEVHAAATNFFDILQIQGKYQLQPPFPWISGAEFAGVVLATPKNSKNPKFPVGSRVFGATQGAYATKCVAKEVSMLPVPEGWSFEEAAGLFVTAPTSYGALVVRAGVKAGDWVLVHAAAGGVGLAAVQVAKAFGATVIATAGTKRKLDVAKSYGADYVIDYRDASWPDRVKKLTKGRGVDIVYDPVGVVDKSTKCIAWNGRILIVGFAAGTIEKVAMNKVLLKNISLVGIHWGQYANFEPQTVPVVWEGIMKLIKEGKFRPTVFTDKKFVGLETVDVIFSTTVKLFSSTVRRALRSSATGLSIAAAAVTSSHRSQPLQSEIKSLQNVGKRKMHSKVVIIGSGPAAHTAAIYLARAELKPVLYEGFMANGIAAGGQLTTTTEVENFPGFPEGVTGQELMEKMRNQSERFGTVIISETVAKLDLSKRPFEYATEWSPDDIHTADAVILATGASAKRLGLPGEEKYWQNGISACAVCDGAVPIFRNKPLVVIGGGDSAAEEALFLTKYGSHVTVLVRRDKLRASAVMAKRLLSHPKITVRFNTVGVEVKGDENGLMSHLVVRDTLTGKEETMEANGLFYAIGHEPATSLVKGQLELDADGYVVTKPGTTLTSVPGVFAAGDVQDKRYRQAITSAGTGCMAALDAEKYLAELEESQEETKAANGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDB6</accession>
    <name>G0SDB6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CTHT_0051200</name>
    </gene>
    <organism evidence="23">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TMEM19 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695462.1">
        <property type="nucleotide sequence ID" value="XM_006695399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDB6"/>
    <dbReference type="STRING" id="759272.G0SDB6"/>
    <dbReference type="GeneID" id="18259158"/>
    <dbReference type="KEGG" id="cthr:CTHT_0051200"/>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_279913_0_0_1"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12122">
        <property type="entry name" value="AMPKA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14079">
        <property type="entry name" value="STKc_AMPK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14334">
        <property type="entry name" value="UBA_SNF1_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000544">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000069">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000236">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032270">
        <property type="entry name" value="AMPK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002794">
        <property type="entry name" value="DUF92_TMEM19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013896">
        <property type="entry name" value="SNF1_UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16579">
        <property type="entry name" value="AdenylateSensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01940">
        <property type="entry name" value="DUF92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08587">
        <property type="entry name" value="UBA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="491"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="303"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="442"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="834"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="889"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="990"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="992"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="520"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EGS18517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1124" mass="124031" checksum="715076270B310747" modified="2011-10-19" version="1">MKPVIAIPATLLLVYRAYVKNSLTPAGIIAAVLTAIAHAIHPWNLPFVLLVVFFLAGTRATRVKEHVKTTLTVKAGGSSGGEGPRTHVQVFANSLTASMLSVLHAYQLRSRQQTLLTDPTGTGSLCFSWGGDLLVVGIIANYACVAADTFSSELGILARSQPRLITSLTLRKVPRGTNGGVTLEGLAAGLLGSVIIVTSAMLFLPFCTKATEGKLGGGPAWTLEQRRLLMGGLALWGLLGSLVDSILGGLFQRSVRDVRSGKIVEGEGGERVLISAPVPEKRTDVGAGIKAALLHGEGEAAVEKTDAVGTGQSGADLSRYDPQNKQRRPSFGDERPSRVVENGWDLLDNNDVNFLMSFGMSIGAMALTERAQGVARNNFWPRESAREPPGVARIWESSQVERSRCWALWPHGNPPLPKNPAIATTTTITNYSCPANPSKSSNPFNHFNHSAMASADRSAAPSSGDSAGGSQNRQQSSHRADRSSESRLSQYQIIKTLGEGSFGKVKLAIHKGTGQKVALKIISRKNLQTRDMKGRVEREIEYLQLLRHPHIIKLYTVIKTPAEIIMVLEFAGGELFDYIVQHGRMHEDEARRFFQQMLCAVEYCHRHKIVHRDLKPENLLLDDNLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVINGKLYAGPEVDVWSCGVILYVLLVGRLPFDHEHIPTLFAKIARGSYMVPTWMSPGAAGLIKKMLVVNPVQRATIDEIRQDPWFLKDLPAYLHPPVEEFYHTGIDPNKAIRPSDIAPHISPQEQQKLHEEVTEKISKTMGYGKQDIEEALESDEPSAIKDAYMIVRENKLMEHSKLTGLTPADDPSHSSRSVTSTTAPRLPYVSKVGILPSSLTVYHKVFMERERAKAEGLELDTAPIAPEPAPQPRSQAEQEESLRRLKPHSRSYARLDDASRPQGLTPANPPKKNKPVRWQFGIRSRNAPWEALVCIYKALYKLGATWLVDEDYDFVHGNRDEDEDDYDSEEGGYSMRRHGRHRGSSSADREQGFYKLPADPWNIKVRWTTDKLQKHSVASGLSDGQEANEFQIVAMRMDIQIYEMESGVYLVDFKVDGYETPDGKLLEEKDVTSPFPFLDMAARLIMQLADAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDQ6</accession>
    <name>G0SDQ6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">S-(hydroxymethyl)glutathione dehydrogenase</fullName>
            <ecNumber evidence="12">1.1.1.284</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0052630</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>S-(hydroxymethyl)glutathione + NAD(+) = S-formylglutathione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-(hydroxymethyl)glutathione + NADP(+) = S-formylglutathione + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-nitrosoglutathione + NADH + H(+) = S-(hydroxysulfenamide)glutathione + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:78371"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:145544"/>
            <dbReference type="ChEBI" id="CHEBI:229723"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a primary alcohol + NAD(+) = an aldehyde + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10736"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a secondary alcohol + NAD(+) = a ketone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17087"/>
            <dbReference type="ChEBI" id="CHEBI:35681"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.284" evidence="12"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695602.1">
        <property type="nucleotide sequence ID" value="XM_006695539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDQ6"/>
    <dbReference type="STRING" id="759272.G0SDQ6"/>
    <dbReference type="GeneID" id="18259301"/>
    <dbReference type="KEGG" id="cthr:CTHT_0052630"/>
    <dbReference type="eggNOG" id="KOG0022">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_14_0_1"/>
    <dbReference type="OMA" id="IKGRSEM"/>
    <dbReference type="OrthoDB" id="417550at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106322">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106321">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080007">
        <property type="term" value="F:S-nitrosoglutathione reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08300">
        <property type="entry name" value="alcohol_DH_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000003">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000001">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014183">
        <property type="entry name" value="ADH_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02818">
        <property type="entry name" value="adh_III_F_hyde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF12">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE CLASS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="14">
        <location>
            <begin position="37"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="13">
        <location>
            <begin position="208"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS18657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="384" mass="40853" checksum="414E403AA540EA7B" modified="2011-10-19" version="1">MSSESTVGKTIVCKAAIAWGAGQPLSYEDVEVAPPKAHEVRIKIYYTGVCHTDAYTLSGKDPEGAFPVILGHEGAGIVESVGEGVTNVKPGDHVIALYTPECRECKFCKSGKTNLCGKIRATQGKGLMPDGTTRFRARGQDILHFMGCSTFSQYTVVADISVVAVQPNAPMDRTCLLGCGITTGYGAATITAKVEKGSNVAVFGVGCVGLSVIQGAVKNGAGRIIAVDVNPAKEEWARKFGATDFVNPNQLPEGKTIVDQLIEMTDGGCDYTFDCTGNVNVMRAALESCHKGWGESIIIGVAAAGQEISTRPFQLVTGRVWKGSAFGGVKGRTQLPGLVQDYLDGKLKVDEFITHRMTLEKINDAFEVMKSGECIRAVLTMQDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDV5</accession>
    <name>G0SDV5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">DNA repair protein REV1</fullName>
            <ecNumber evidence="16">2.7.7.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CTHT_0053130</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents. Involved in mitochondrial DNA mutagenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="17">Binds 2 magnesium ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="16"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695651.1">
        <property type="nucleotide sequence ID" value="XM_006695588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDV5"/>
    <dbReference type="STRING" id="759272.G0SDV5"/>
    <dbReference type="GeneID" id="18259351"/>
    <dbReference type="KEGG" id="cthr:CTHT_0053130"/>
    <dbReference type="eggNOG" id="KOG2093">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003901_1_1_1"/>
    <dbReference type="OMA" id="IKNGMWM"/>
    <dbReference type="OrthoDB" id="427711at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017125">
        <property type="term" value="F:deoxycytidyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17719">
        <property type="entry name" value="BRCT_Rev1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01701">
        <property type="entry name" value="PolY_Rev1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000001">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000040">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000011">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1280">
        <property type="entry name" value="DNA repair protein Rev1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053848">
        <property type="entry name" value="IMS_HHH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012112">
        <property type="entry name" value="REV1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031991">
        <property type="entry name" value="Rev1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038401">
        <property type="entry name" value="Rev1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21999">
        <property type="entry name" value="IMS_HHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16727">
        <property type="entry name" value="REV1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14377">
        <property type="entry name" value="UBM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036573">
        <property type="entry name" value="REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 16" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="11 16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="19">
        <location>
            <begin position="61"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="UmuC" evidence="20">
        <location>
            <begin position="419"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="244"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="818"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="949"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1000"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1088"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="253"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="303"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="317"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="957"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1061"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="1095"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="519"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="520"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00058985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR036573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR036573-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EGS18706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1268" mass="140624" checksum="079FA8C41D165966" modified="2011-10-19" version="1">MGNRLEKNSAAVRKAIESRRFTDEDGEEYEANKFGGFADYFRRKQEKLQNLDSELRAAAKDKPQIFKGVVAHVTGYTQPPLHVLHKELVQHGAGFLQYLGGKTMATHIIASTMPPTKAIDYSKYRVVKPAWVMDSIKAGRMLPWQDYRVITEGPKQKTIAFGSGKLVSKATPQKQASYREQSDNSFYTSQFKNAQSQVGGNPFRGPPQKSAYAPADFEIEDIEKWDDINFGSHEKVRTQGKTITEPLLSKHGQPSPAVSPSKPSSSAQRQSSPAIPAFKPPSSAKKPPIEPTTVSLEPPPSAQRPTSLPPTSAQRPPLLPKPAPEPPLPAQKPTPHLLAPPTKPMTAEEHNALLLADPKIRKSSAANPNFLKQYYSESRLHHLSTWKAQLKSRLQALAASKALPTASKKKRPSGARRYILHVDFDSFFCAVSSLKLPEEERGKPAAVAHGTGPGSEIASCNYPARVYGVRNGMWMARAMELCPTLRILPYDFTAYEDASGKFYEAILSIGGVVQAVSIDEALVDVTDIVMERTGSEGIGVSEGSVWREQKEVDQIALGLREEIKRKTGCNVSVGIGGNILLAKIALRKAKPAGQYHLRPEEVLEFIGELKVEDLPGVAYSIGGKLEEMGIKYVKDLRGVSKEKLASVLGPKTGEKLYEYARGIDRTEVGDQPMRKSVSADVNWGIRFVSQEEAEEFVRNLCKELERRLLNEGVKGRHLTMRIMRRSPDAPLEPAKHLGHGKCDVFTKSVAFGVPTNDPELIGKEAVTILRSFRFSPGDLRGIGLQMTKLEPIKPSGKPEGSQKKLTFAVPVKRQMEQAVEESNAQTAKQEPVKPVGKQEEAQNKVTFAPPPAKKQKTAATEAIEESDLQTYRPRPSEGPEIEDDPITDEPLTPPKPKVHPALALAKAGEADEKAISPLNIAGTQFIIPSNPDPAILAELPQDIRSRLVHPQQARRTPPAPAQPEPASQPHPPDLPPDVDPEVFAALPDDVKAEVLAEYRVQRPQQQRSPPRHGKGGLKQQTLLPQSPHKNRVIFKPPVPRTSTKRGSGGRGRGGLFSHASRAHERKKDREAGLRQTRFVAIPRRLIEQYHGKDPNEEDDEPDIPELDPNTLAELPTQIRTKVVAEHRAAKERQRQRRLERNGAVLTFYAPTPPMGVELRRELDKRWENRLRGVKFPPLPTHAKLASKEIKTLEEVREMVSTWYEESREEGGPHPEDVECFAEWLAQVVKGERNIEKAGKVLRWLEWIVSEGEPDGQEGEGDEGQKEWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0SE79</accession>
    <name>G0SE79_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aconitate hydratase, mitochondrial</fullName>
            <shortName evidence="9">Aconitase</shortName>
            <ecNumber evidence="9">4.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0062780</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696587.1">
        <property type="nucleotide sequence ID" value="XM_006696524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SE79"/>
    <dbReference type="STRING" id="759272.G0SE79"/>
    <dbReference type="GeneID" id="18260316"/>
    <dbReference type="KEGG" id="cthr:CTHT_0062780"/>
    <dbReference type="eggNOG" id="KOG0453">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006714_2_2_1"/>
    <dbReference type="OMA" id="KWPETFG"/>
    <dbReference type="OrthoDB" id="2224430at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000003">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000004">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1060.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005558">
        <property type="entry name" value="PRK07229.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF2">
        <property type="entry name" value="HOMOCITRATE DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="10">
        <location>
            <begin position="93"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="11">
        <location>
            <begin position="608"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS18256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="812" mass="88086" checksum="17E848BE6B872FF2" modified="2011-10-19" version="1">MRPIELVGRSGAALRRAFQAQQLRRVAVSTRPYSSASPNGTLPPTYEKLYSKYSEVRRVLGAQRLTLAEKILYSHLDNVEESLLSNTNNGKDIRGKANLKLRPDRVNMQDASAQMALLQFISCNVPRTAIPASIHCDHLIIGERGAEEDLAAGINTNQEVFDFLESSAKRYGIDFWPPGAGIIHQTVLENYALPGMMMLGTDSHSPNAGGLCTITIGVGGADAVEALVGAPWELKAPKILGVRLTGQLNDWVSPKDLILHLAGLLTVRGGTGYIVEYFGPGVETLSLTGMATVCNMGAEIGATTSIFPFTEASARYLKATRREQAAKDAALFQTWPGAGAAEDAYFRFKADEGAQYDELIEIDLSKLEPHLNGPFTPDLAIPLSKFKETVQKEGWPEKLSAGLIGSCTNSSYEDMTKVESIVRAAHEAGLKPKADFYITPGSEQIRSTLERDGTLETFNKAGGILLSNACGPCIGQWKRHDGIEKGTPNAILTSYNRNFRGRNDGNPATLNFLASPEIVTAMAYAGSTTFNPITDTITTPDGKEFRFPSPRGKEGPETPFSQGRETFRVASNPPDPSVPVAISPSSERLALLEPFDPFPAGDLTGLRVLVKVSGKCTTDTISAAGPWLKYKGHLPNISANTLNTAVNAETGEVNAAYDHPLDGRKYTIPELARLWKERGQAWLVVAEHNYGEGSAREHAALQPRYLGARVIVCKSFARIHETNLKKQGVVPLTFEEPDRDYERIGAGDIVDTIGLYEMLQNGGKGDVKLRVTKHKTGEVFEIPVKHQVSEDQAKFILAGSALNLLAKNAALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0SE97</accession>
    <name>G0SE97_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative L-ascorbic acid binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0062980</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696605.1">
        <property type="nucleotide sequence ID" value="XM_006696542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SE97"/>
    <dbReference type="STRING" id="759272.G0SE97"/>
    <dbReference type="GeneID" id="18260336"/>
    <dbReference type="KEGG" id="cthr:CTHT_0062980"/>
    <dbReference type="eggNOG" id="ENOG502S24K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1156267_0_0_1"/>
    <dbReference type="OMA" id="SECTQMI"/>
    <dbReference type="OrthoDB" id="69177at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit Fe(2+) 2OG dioxygenase" evidence="1">
        <location>
            <begin position="123"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="240" mass="26608" checksum="256D6B1C5178BC81" modified="2011-10-19" version="1">MRGVISNLLAKPKPDQRPSFRVLPPTNNQFHPSSIKTAYDSLPVPLPPNFLSCDPSHLPPDSKPITLTPINFPASGFPEYDGCVAMVLDHVLSPSECKTLLQLAEQSVPEIIKAVNQGNTHCDGSYTAHPDPFRPVKTLFTVHLYLNDSQAEDPSAELAGGSTPFFSPDETRGLDVHPKAGRVLIFQHYRLVHSGDDVRTGTKYTVRMDLLYEFVPKEDLDDEGRKVQDTDMVQDTDIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0SE99</accession>
    <name>G0SE99_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0063000</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 10"/>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696607.1">
        <property type="nucleotide sequence ID" value="XM_006696544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SE99"/>
    <dbReference type="STRING" id="759272.G0SE99"/>
    <dbReference type="GeneID" id="18260338"/>
    <dbReference type="KEGG" id="cthr:CTHT_0063000"/>
    <dbReference type="eggNOG" id="ENOG502QSWP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025694_1_2_1"/>
    <dbReference type="OMA" id="WSQSMGN"/>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF36">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409469" description="Mannan endo-1,6-alpha-mannosidase" evidence="13">
        <location>
            <begin position="26"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="401"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS18276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="460" mass="50556" checksum="2D6271B4FE73DB0E" modified="2011-10-19" version="1">MLPLSLSSPRWLATAVLLGARVTYAAFKLDTIEDIKETAATVAWDLMQYYHGNESGQTPGILPGPPPAGDYYWWEAGAMWGTLIDYWHWTGDDSYNDVITQAMLWQVGPNRDYMPPNVTASLGNDDQGFWGMSAMLAAENGFPDPPEDEPQWLALAQAVFNTQASPTRHDDTCGGGLRWQIPWSNNGYNYKNSIANGCFFNLGARLARYTGNQSYADWAEKTWDWMVGVGYIDKDYNIYDGGHVEQNCTDINRAQFSYNNAIFLLGAAYMYNYTNGSDVWAARVNGLVNSTLRTFFRDNVAYEVACEEHMSCTTDMLSFKGYLHRWLATATEVAPFIRDTVLPVLRTSAEAAVSTCTGEENGRTCGFQWVKRQYDGSKGAGQQMNVLGAVSALLVEYSKPPLTNGTGGTSKGDPMAGSRSDTLTQEVKPPTGGDKAGAAILTFVVLATTVGAFTWMSMGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEP8</accession>
    <name>G0SEP8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0064520</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696756.1">
        <property type="nucleotide sequence ID" value="XM_006696693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEP8"/>
    <dbReference type="STRING" id="759272.G0SEP8"/>
    <dbReference type="GeneID" id="18260490"/>
    <dbReference type="KEGG" id="cthr:CTHT_0064520"/>
    <dbReference type="eggNOG" id="KOG0069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_0_1"/>
    <dbReference type="OMA" id="VQMAEYV"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12160">
        <property type="entry name" value="2-Hacid_dh_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333">
        <property type="entry name" value="2-HACID_DH_C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE NAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="3">
        <location>
            <begin position="105"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS18425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="316" mass="34598" checksum="37512333FCD7BE12" modified="2011-10-19" version="1">MKLLYPNTLKLDPSAIAGFPTVTLHLYDARAPTIPDELLDAEILVTWANSPANLKFAAQNMPNLRWIQSLAAGPNDVLNAGFDRSRITVTTGSGLHDRTVAEHTLGLLLNAARRFYEMRDYQLQGKWPGHLGGPQPDREKGTFRTLRDANVLVWGFGNIAKCLTPLLTALGARVRGVARRAGVRAGVEVFTEDKLPDLLPETDALVMILPGDPSTRHALNKERLALLPKHAWVVNVGRGTSVDEDALFEALEKGEIGGAALDVFETEPLPEGDKLYKAPNLILSPHAAGGRPQDSEELIVYNLRRFLAGQDLRNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>G0SF76</accession>
    <name>G0SF76_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0061070</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696423.1">
        <property type="nucleotide sequence ID" value="XM_006696360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SF76"/>
    <dbReference type="GeneID" id="18260145"/>
    <dbReference type="KEGG" id="cthr:CTHT_0061070"/>
    <dbReference type="HOGENOM" id="CLU_2468867_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="88" mass="9505" checksum="A03E3E72F241F332" modified="2011-10-19" version="1">MKACPSPPPPRGGSPASSLLPSLPPCPNSSGYRKRSDCLPDGSQPDVQDRVSRHGDALLREIVNKIIRQVDTIEKLMETTSSDSETMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFI5</accession>
    <name>G0SFI5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Autophagy-related protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CTHT_0070950</name>
    </gene>
    <organism evidence="23">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer. Forms a ternary complex with ATG13 and ATG17.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697368.1">
        <property type="nucleotide sequence ID" value="XM_006697305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFI5"/>
    <dbReference type="STRING" id="759272.G0SFI5"/>
    <dbReference type="GeneID" id="18261133"/>
    <dbReference type="KEGG" id="cthr:CTHT_0070950"/>
    <dbReference type="eggNOG" id="KOG0595">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006447_0_0_1"/>
    <dbReference type="OMA" id="INNVVQW"/>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14009">
        <property type="entry name" value="STKc_ATG1_ULK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000817">
        <property type="entry name" value="Serine/threonine-protein kinase ATG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048941">
        <property type="entry name" value="ATG1-like_MIT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022708">
        <property type="entry name" value="Atg1-like_tMIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12063">
        <property type="entry name" value="ATG1-like_MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21127">
        <property type="entry name" value="ATG1-like_MIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 22" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 22" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="26"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="350"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="530"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="814"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="897"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="963"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="454"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="545"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="568"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="582"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="821"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="908"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="969"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="20">
        <location>
            <begin position="979"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00060750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EGS17750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1008" mass="109664" checksum="90AE6396F99D0CA5" modified="2011-10-19" version="1">MADRTAATSKRSSSSRHGEDNVVGQFIIDKEIGKGSFAQVYSGRHKVTGALVAIKSVELARLNKKLKDNLYGEIKILKKLRHPHIVALHDCVESATHINLIMEYCELGDLSLFIRKRDKLITNSATHELARKYPVSPNSGLHEVVSRHFLQQLASALKFLRAANLIHRDVKPQNLLLLPSPRWRETNKLAKQILSASHDSLTPAAGLPSLPMLKLADFGFARVLPSTSLAETLCGSPLYMAPEILRYERYDARADLWSVGTVLFEMVTGKPPFRASNHVELIRKIEQAEDCIKFSRDCVVSSEMKQLIRALLKRNPDERIDFDDFFNHPVVVGPIPGVVEEDIQLQEQARAQLQQAQAPVEPKSSTPKPEDPLLRRRQSLVDAEVTQPPGSPRHRHASPLTTPVEPKPSSLDSPRLSYSPRQDAPDATRRAAIQPSTSAPGTRPIAYVDRTRRYSNTSRPTSRMAQSPSTPVEEPKKKSSSSKTLTEEERVAQDIAFERDYIFVDKIAVEVNALADQISMYKNQQVLQQQQQQVSSSPKSGQLIRRSSQRNAPASTSGAVARSASTRESTRTDHSRRASYEKSLSSSPGGATSMISKAIQDASLRLFGIKYTPSLLGGGRSGHSPPPQIYNPFPTAYATPAGLIADGSANGSGSGIASAGKVIIDEDARVAQCIEEYATRSDVVYGFAEVKYKQLVPMAPSSDHGLGGVPADRMGEEEDGLTPEAIVALSEEALVLYVKALSIMNKAMHIAGAWWTKHQQRAAVEATNGNGNGAADKFAKKINAAVQWIRNRFNEVLEKAEVVRLKLIDAQKRLPEEHPSHPSNHPPETGSHSGAASGSSGVYLSPGMSAEKLMYDRAVEMSRTAAINEIASEDLPGCEISYVTAIRMLEAVLESDDEQGVGPLGGGKKGEGKDKGKEEETGANGGGMGNGVMSVEDRATVQKMIQMINTRLTSLRKRMAAIANASRAQQQQQQSQQGQGLGQSPGQGGMVMGHRRSGEGSRSGMPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2023-09-13" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFK7</accession>
    <name>G0SFK7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ankyrin repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0071190</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697390.1">
        <property type="nucleotide sequence ID" value="XM_006697327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFK7"/>
    <dbReference type="GeneID" id="18261157"/>
    <dbReference type="KEGG" id="cthr:CTHT_0071190"/>
    <dbReference type="HOGENOM" id="CLU_1981409_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="13840" checksum="615F53210695991F" modified="2011-10-19" version="1">MGSVNPHPPSQRNAPPLINSLHKAILSNDYHGVRILIAPNKNNVDQRLEAEGATFLMVAVLLGRLKIATLTSPKLSAAQPHIRSQQDRPNDDEQPQENNDSVEIVVDEDDRTVSHVAATEPIKVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFL7</accession>
    <name>G0SFL7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hemerythrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0071290</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697400.1">
        <property type="nucleotide sequence ID" value="XM_006697337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFL7"/>
    <dbReference type="GeneID" id="18261167"/>
    <dbReference type="KEGG" id="cthr:CTHT_0071290"/>
    <dbReference type="eggNOG" id="ENOG502S4CP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074846_1_1_1"/>
    <dbReference type="OMA" id="AEHMDYF"/>
    <dbReference type="OrthoDB" id="10044044at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12108">
        <property type="entry name" value="Hr-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053206">
        <property type="entry name" value="Dimeric_xanthone_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048:SF1">
        <property type="entry name" value="HEMERYTHRIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="2">
        <location>
            <begin position="70"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="237" mass="27872" checksum="33B39232D38FFE8F" modified="2011-10-19" version="1">MQETEGNIICHSARFETDPLEEDSYKSETAQETTGASSKDKSTTTSQPEPEQALPPLTPQEFRIYNRLAEQMEYFHDHFRQIWNLLYTACANNRRPGNLTLKQFHDEGLRLARYLETHHTIEETYLYPLLARKMPEFRSSLPPSHFRKGNSKGGKSKGEQCELIRQHQLIHEGMEEFVEYLERCKRKECELELGVLKEKMDSWGEVLMKHLDQEVRDLGAEKMSRYWTVEEMRGFPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFR8</accession>
    <name>G0SFR8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aldo-keto reductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0071880</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697451.1">
        <property type="nucleotide sequence ID" value="XM_006697388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFR8"/>
    <dbReference type="STRING" id="759272.G0SFR8"/>
    <dbReference type="GeneID" id="18261226"/>
    <dbReference type="KEGG" id="cthr:CTHT_0071880"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_1_1"/>
    <dbReference type="OMA" id="FMTMKAA"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000015">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="27"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="5">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS17833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="291" mass="32576" checksum="0083BAC6F40153E6" modified="2011-10-19" version="1">MASLSISTTLKLASGYDIPQLGFGVYQTPAKDAAGLVTEAFETGYRHVDSAAAYRNERPCGEAIRSSPIPRSQLFFTTKIPVKAVSYEGAKAQIDKSLAETGLDYLDLVLIHAPYGGSENRKGAWKALVEAVEEGKVRSIGISNYGVHHLRELEQHIAELERERGGKGKGGVISVGQWEIHPWCLREDIVAWCKEKRVVVEAYSPLVRGKRWGEPVTKKLAEKYGKTEAQVLIRWSLQKGYVPLPKTVHSERIKENADVYDFELTPEEMKELETDEYSPVCWDPTRSKLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFS6</accession>
    <name>G0SFS6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10 11">Catalase-peroxidase</fullName>
            <shortName evidence="10">CP</shortName>
            <ecNumber evidence="10 11">1.11.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Peroxidase/catalase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">katG</name>
        <name evidence="13" type="ORF">CTHT_0071960</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 10 11">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10 11">
            <text>H2O2 + AH2 = A + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:30275"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="10">Binds 1 heme b (iron(II)-protoporphyrin IX) group per monomer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10">Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the peroxidase family. Peroxidase/catalase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.21" evidence="10 11"/>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697459.1">
        <property type="nucleotide sequence ID" value="XM_006697396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFS6"/>
    <dbReference type="STRING" id="759272.G0SFS6"/>
    <dbReference type="PeroxiBase" id="10063">
        <property type="entry name" value="CtheCP01"/>
    </dbReference>
    <dbReference type="GeneID" id="18261234"/>
    <dbReference type="KEGG" id="cthr:CTHT_0071960"/>
    <dbReference type="eggNOG" id="ENOG502QTDY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025424_2_0_1"/>
    <dbReference type="OMA" id="GPETTWL"/>
    <dbReference type="OrthoDB" id="407695at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070301">
        <property type="term" value="P:cellular response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00649">
        <property type="entry name" value="catalase_peroxidase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08200">
        <property type="entry name" value="catalase_peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000002">
        <property type="entry name" value="Catalase-peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000004">
        <property type="entry name" value="Catalase-peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000002">
        <property type="entry name" value="Catalase-peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01961">
        <property type="entry name" value="Catal_peroxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000763">
        <property type="entry name" value="Catalase_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00198">
        <property type="entry name" value="cat_per_HPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011635">
        <property type="entry name" value="PRK15061.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30555:SF0">
        <property type="entry name" value="CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30555">
        <property type="entry name" value="HYDROPEROXIDASE I, BIFUNCTIONAL CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00460">
        <property type="entry name" value="BPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10 11" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="5 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="3 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 10 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 10 11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="12">
        <location>
            <begin position="124"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="cross-link" description="Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-90)" evidence="10">
        <location>
            <begin position="218"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS17841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="723" mass="80204" checksum="C0457837C245E9F4" modified="2011-10-19" version="1">MGECPVRHDNVAGGGTRNTDWWPKQLRLNILRQHQPASNPYPKDFDYAAAFKSLDYEALKQDIKAVLTDSQDWWPADFGHYGGLFIRMAWHSAGTYRVFDGRGGGGQGQQRFAPLNSWPDNVSLDKARRLLWPVKQKYGDKISWADLMLLAGNVALESMGLKTFGFAGGRPDTWEADESAYWGGETTWLGNEVRYANKDIKNRELETPLAAAHMGLIYVNPEGPDGNPDPVAAARDIRITFGRMAMNDEETVALIAGGHTFGKTHGAGPTDNVGKEPEAAPIEEQGFGWSNKFGSGKGPDTITSGLEVIWTKTPTQWSTNFLEYLFKFDWELTKSPAGANQWVAKNAEAFIPDPYDPSKKHPPRMLTTDLALRFDPVYEKISRRFLEHPDEFADAFARAWFKLLHRDMGPRTRWLGPEIPSEILPWEDYIPPVDYPVIDDADVAALKQTILATGIAPHKLISTAWASASTFRGSDKRGGANGARIRLAPQKDWPVNNPAQLAEVLSALEAVQAQFNSTAPGGKKVSLADLIVLGGVAALEQAAGVPVPFTPGRNDTTQEYTEVESFSYLEPVADGFRNYGRGTDRVRTEQLLVDRAHLLTLTPPEMTVLVGGLRVLGANWDGSTHGVFTKRPGQLTNDFFVNLLDMSTAWRSIDGEIFEGYDRKTGEKKWTATRVDLIFGSHAELRAIAEVYASADGQEKFVRDFIAAWDKVMNLDRFDLGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFU1</accession>
    <name>G0SFU1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo-keto reductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0072130</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697474.1">
        <property type="nucleotide sequence ID" value="XM_006697411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFU1"/>
    <dbReference type="STRING" id="759272.G0SFU1"/>
    <dbReference type="GeneID" id="18261251"/>
    <dbReference type="KEGG" id="cthr:CTHT_0072130"/>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_1_1"/>
    <dbReference type="OMA" id="YIDLLYC"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF40">
        <property type="entry name" value="ALDO-KETO REDUCTASE YAKC [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="64"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="333" mass="37400" checksum="C8244A9DDE3B179D" modified="2011-10-19" version="1">MAQPSIPTRQLGRDGPTIPILGLGLMGLSSFYGTPPPEEERLQFLDRAHELGCRHWDTAALSDGGREFRNDPEFIRQAVKDALSRLKTDYIDLLYCHRISGKTPIEDIVSTMKEFVVYHPPPKEHLPRTLALTPLKLSSSGQVRYLGLSECGADTLRRAVRIHPIHAYQAEYSPFTRDIEHPSLNLLSTCRELGIGIVAYCPLGRGMLTGKYTSLEQFEAGDFRKAVPRFMGENFERNMELVRALGKVAARKGCTTGQLVLGWLMRQEGVFPIPGTKRVQYLEENWGANAVYGGLTEEEVRELRELIEGMQVWGERYPVAMMGGLLKDTPPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFW1</accession>
    <name>G0SFW1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0072340</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697494.1">
        <property type="nucleotide sequence ID" value="XM_006697431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFW1"/>
    <dbReference type="GeneID" id="18261272"/>
    <dbReference type="KEGG" id="cthr:CTHT_0072340"/>
    <dbReference type="eggNOG" id="ENOG502S00D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052989_2_0_1"/>
    <dbReference type="OMA" id="AWIAMNG"/>
    <dbReference type="OrthoDB" id="5233393at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052998">
        <property type="entry name" value="Hetero-Diels-Alderase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42060:SF1">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42060">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012632903" description="SMP-30/Gluconolactonase/LRE-like region domain-containing protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="30607" checksum="69D30C1AD81D3521" modified="2011-10-19" version="1">MRLTILLLTAPLVQGACLTPRQSAATQIVSLSSLENLAIRSNGQILATNMNSAQLYSVDPVSKTYTAALTVSGASPGLSGIGEVTPDVFAVIGGTKQVYKVDFTVNPPTSSLIATIQEANNLNGLAVFDNSSVLLADAGRGVVYKLNVANARYEQVLSDPTMTPTGGIPFGIDGIKYDAKTSTVWYTNIFRNSLHSLPVEPTTAKATGVVKTWWTNLMGDDLCLSGDTGKVYVTTNMGGNSLVELDPSVGEESRKTIGSVQGSTACAFGRREGDTGTVYVTGAQGLFAVQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0SG09</accession>
    <name>G0SG09_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cinnamyl-alcohol dehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0064620</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696766.1">
        <property type="nucleotide sequence ID" value="XM_006696703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SG09"/>
    <dbReference type="STRING" id="759272.G0SG09"/>
    <dbReference type="GeneID" id="18260500"/>
    <dbReference type="KEGG" id="cthr:CTHT_0064620"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="OMA" id="GHWCELG"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="237" mass="26634" checksum="C4B785655FEB3570" modified="2011-10-19" version="1">MTKEAGEKVLLTGTGFIASHVLDCLLDHGSPEKGQRILESTRESLRTRVSYVVVEDVAEEGAFDETFAESAAWKFVAVESPGFDLVAINNTYTFGPIPRSLAGLEALNTSNHRIRDLVHGHWCELGVPATYPVFTFVDVRDVALAHVRALTVPEAGGKRFYVVGGFFSNPRLVQIVRQHFPELKNRLPEETTVTDDFPENHWKFDNRRSREVLGIEYTSLEESVVDTVRSILEFERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGE9</accession>
    <name>G0SGE9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0066080</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="4 5 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Struct. Mol. Biol." volume="26" first="830" last="839">
            <title>Cryo-EM reveals active site coordination within a multienzyme pre-rRNA processing complex.</title>
            <authorList>
                <person name="Pillon M.C."/>
                <person name="Hsu A.L."/>
                <person name="Krahn J.M."/>
                <person name="Williams J.G."/>
                <person name="Goslen K.H."/>
                <person name="Sobhany M."/>
                <person name="Borgnia M.J."/>
                <person name="Stanley R.E."/>
            </authorList>
            <dbReference type="PubMed" id="31488907"/>
            <dbReference type="DOI" id="10.1038/s41594-019-0289-8"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.90 ANGSTROMS)</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e57984" last="e57984">
            <title>Structural insights into coordinating 5S RNP rotation with ITS2 pre-RNA processing during ribosome formation.</title>
            <authorList>
                <person name="Thoms M."/>
                <person name="Lau B."/>
                <person name="Cheng J."/>
                <person name="Fromm L."/>
                <person name="Denk T."/>
                <person name="Kellner N."/>
                <person name="Flemming D."/>
                <person name="Fischer P."/>
                <person name="Falquet L."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="37921038"/>
            <dbReference type="DOI" id="10.15252/embr.202357984"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.01 ANGSTROMS)</scope>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696906.1">
        <property type="nucleotide sequence ID" value="XM_006696843.1"/>
    </dbReference>
    <dbReference type="PDB" id="6OF2">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="A/D=1-363"/>
    </dbReference>
    <dbReference type="PDB" id="6OF3">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="A/D=1-363"/>
    </dbReference>
    <dbReference type="PDB" id="6OF4">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="A/D=1-363"/>
    </dbReference>
    <dbReference type="PDB" id="8PUW">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.01 A"/>
        <property type="chains" value="A/D=1-363"/>
    </dbReference>
    <dbReference type="PDBsum" id="6OF2"/>
    <dbReference type="PDBsum" id="6OF3"/>
    <dbReference type="PDBsum" id="6OF4"/>
    <dbReference type="AlphaFoldDB" id="G0SGE9"/>
    <dbReference type="EMDB" id="EMD-17949"/>
    <dbReference type="EMDB" id="EMD-20040"/>
    <dbReference type="EMDB" id="EMD-20041"/>
    <dbReference type="EMDB" id="EMD-20042"/>
    <dbReference type="SMR" id="G0SGE9"/>
    <dbReference type="STRING" id="759272.G0SGE9"/>
    <dbReference type="GeneID" id="18260646"/>
    <dbReference type="KEGG" id="cthr:CTHT_0066080"/>
    <dbReference type="eggNOG" id="KOG2425">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019519_1_0_1"/>
    <dbReference type="OMA" id="ALEWIWW"/>
    <dbReference type="OrthoDB" id="10263222at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090730">
        <property type="term" value="C:Las1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007174">
        <property type="entry name" value="Las1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002:SF0">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04031">
        <property type="entry name" value="Las1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4 5 6" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="6OF2"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="6OF3"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="6OF4"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="8PUW"/>
        </source>
    </evidence>
    <sequence length="363" mass="40408" checksum="88CA4B5AC7D7A1F8" modified="2011-10-19" version="1">MVQYIFTPWRNRAELLAVRAQFYPEHTSKTHLKKHHQSTFQDDEHIRSEKQKAVARVSMWMQRGGCPHMVESTALLVAAILSDEAQGSGAAGGYAVRAAYSAAFSRFVTGLLDSHQDKQRKQSMYDVAKAVGLPAAFVELRHQATHEQLPSLTRLRSAARRALEWIWWYYWKGLGPVDMVQRGVNGKGVAGVGDTSESEEKDVGEEGGDAAARCREGVVRLLESDVRVGGEAINGPGKEELLAEFGEALVLTTLDAAAGNTRDVGVLRRAIGLMREIVNGGDEDCMQLENGKGNRDVEKLKEELKKGWEEIKRLAQEKEDSGDDQTEDEDVDMEAEEEDKKEQQSGWVLYDEKEWVPKPIGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGV4</accession>
    <name>G0SGV4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC1 atypical kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0067700</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697061.1">
        <property type="nucleotide sequence ID" value="XM_006696998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGV4"/>
    <dbReference type="STRING" id="759272.G0SGV4"/>
    <dbReference type="GeneID" id="18260808"/>
    <dbReference type="KEGG" id="cthr:CTHT_0067700"/>
    <dbReference type="eggNOG" id="KOG1234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006533_5_0_1"/>
    <dbReference type="OMA" id="FMTNKGS"/>
    <dbReference type="OrthoDB" id="201153at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051409">
        <property type="entry name" value="Atypical_kinase_ADCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851:SF3">
        <property type="entry name" value="COENZYME Q8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="6">
        <location>
            <begin position="476"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="43"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="238"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="276"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="327"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="122"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="139"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="283"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="338"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS17443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="827" mass="90961" checksum="D3DEBE74F6BA1947" modified="2011-10-19" version="1">MRFADILVDLAAVASASRSIASKHIALRARQWDRYTRESSILGQAMRVRGSNGQTKKTGQGQAQEQSKGEEQKREQIQQQQQHEVGQKQQQQQGDVRVEEAKAAQTETTTQTETVQQTVQKSQPTRPESITPSSVKEISPTPLTTSTSAPAEQAQSSSSTSTPPSQTREFTPAPWANGTIHLLKQQREQGIGRLGPSISPVQPIQPSLAGLEGIGILKKKPAAGLPKVLEMLQGVEAELSKESEGEGIKEEAKQVEEQKQEERQVQVGIEVTEKVGEVKAEPQAEPVQVQETTEVEEPAPAKVEPEAAPAQVEEIENVEEVTPEIAEPKPAPASVEVAPKEKEIQPEVKAEAPSPAPEPKLSQEDANLVAELSNPISSAAPGHQLRESAVPSTRLSRLWNYGGLAAGMVAGALTEGLSRAFGGGSNTGSVMLSPANMERLVSKLSRMRGAALKLGQMMSFQDAKMLPPAIQEVLQRVQDRADYMPGWQRDKVMVNNLGENWRELFEEFEETPVAAASIGQVHRAKLKSTGEQVAVKIQFPGVADSINSDLDNLGILLNATKLLPKGLYLDKTIANARTELAWECDYVREAGCAERYRELLADDGVFAVPRIYREACGKHVLTMEWMPGTAVTRAAPALDQAQRDWIGSQILRLCLREITEFRFMQTDPNWTNFLYNPSNSGRLELLDFGASREYPEEFVSLYVRLLHAASRADRAAVKSLSEELGYLTGHESRTMLDAHVTSVLTLAEPFMESAPEVYDFRGQTITERVKAQIPVMIHERLAPPPEETYSLHRKLSGAFLLCARLGSRVRCRDLFEEAVRKSGYVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0SH72</accession>
    <name>G0SH72_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0068950</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697179.1">
        <property type="nucleotide sequence ID" value="XM_006697116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SH72"/>
    <dbReference type="STRING" id="759272.G0SH72"/>
    <dbReference type="GeneID" id="18260933"/>
    <dbReference type="KEGG" id="cthr:CTHT_0068950"/>
    <dbReference type="eggNOG" id="KOG2204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003818_0_1_1"/>
    <dbReference type="OMA" id="DTCVWAY"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000037">
        <property type="entry name" value="alpha-1,2-Mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF89">
        <property type="entry name" value="ALPHA-1,2-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="442"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="530"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="328"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS17561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="548" mass="61922" checksum="464735DBA80F2C5E" modified="2011-10-19" version="1">MLPLPTSQPSLLPKLQHDFALESSSERELRLQRRDAVKAAMKRCWSSYRRLAWRSDELAPVSGKKLNPFGGWGATLVDSLDTLWIMDMKDEFYEAVTAAATIDFESVGEDLINVFETNIRYLGGFLGAYELSGDKRLLAKAREVGEMLYVAFDTPNRMPITRWDARAAAQGKKQQAPEHALIAELGTFALEFIRLSMITGDPKWFDAVQRITSTLRASQNTTLLPGLWPVVVNPRNEDFSSHPDYTLGAMADSLFEYLPKTHALMGGLLPEYREMYEVAMDTAIRENLFRPMVPDNADILISGFVTVHKRDDGSRTIYLKPEAQHLVCFAGGMLLLGGKLIGNDTHVDKGTKITDGCVWTYNATPSGIMPENFFMLPCKESQNDSDDKDCPWDPERWKRAVLLKAGLDPEKDADKADAIIEEKHLPQGIIAIRDGKYHLRPEAIESVFILYRLTGRKDLLDTAWQMWRAIEENTRTPLANSGLVDVTAPRGKSAKLDRMESFWIGETLKYFYLMFSEPDLISLDDYVLNTEAHPLKRLKPLTAEQTYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHB3</accession>
    <name>G0SHB3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0069410</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697220.1">
        <property type="nucleotide sequence ID" value="XM_006697157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHB3"/>
    <dbReference type="STRING" id="759272.G0SHB3"/>
    <dbReference type="GeneID" id="18260979"/>
    <dbReference type="KEGG" id="cthr:CTHT_0069410"/>
    <dbReference type="eggNOG" id="KOG3405">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112527_0_2_1"/>
    <dbReference type="OMA" id="ADYWDPE"/>
    <dbReference type="OrthoDB" id="259769at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.940.10:FF:000009">
        <property type="entry name" value="DNA-directed RNA polymerases I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00192">
        <property type="entry name" value="RNApol_arch_Rpo6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020708">
        <property type="entry name" value="DNA-dir_RNA_polK_14-18kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028363">
        <property type="entry name" value="RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006111">
        <property type="entry name" value="Rpo6/Rpb6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002208">
        <property type="entry name" value="PRK01099.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500154">
        <property type="entry name" value="RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000778">
        <property type="entry name" value="RpoK/RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="RPB6/omega subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01111">
        <property type="entry name" value="RNA_POL_K_14KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS17602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="158" mass="18079" checksum="C4BD03E36F3A4E0D" modified="2011-10-19" version="1">MSDYGDDDRELVNDEPTFDEDPDEYYEPEPEPADEDEAVRQADQEGEQGDQDHVIVSGDPNAAANHGKGNDKSHKDKKIPNDQRTTTPFMTKYERARILGTRALQISMNAPVLVDLEGETDPLQIAIKELREKKIPLIVRRYLPDGYYEDWTCEELLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHY4</accession>
    <name>G0SHY4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">GTP-binding protein ypt5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0073810</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697636.1">
        <property type="nucleotide sequence ID" value="XM_006697573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHY4"/>
    <dbReference type="STRING" id="759272.G0SHY4"/>
    <dbReference type="GeneID" id="18261419"/>
    <dbReference type="KEGG" id="cthr:CTHT_0073810"/>
    <dbReference type="eggNOG" id="KOG0092">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_10_2_1"/>
    <dbReference type="OMA" id="DEEGLMW"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000464">
        <property type="entry name" value="GTP-binding protein ypt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="187"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS17054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="23784" checksum="3EB90E1A0F7D35A7" modified="2011-10-19" version="1">MATRGPPGARGNTRFAQFKLVLLGESAVGKSSIVLRFVKDQFDSYRESTIGAAFLTQTISLDENTTVKFEIWDTAGQERYKSLAPMYYRNANCAVVVYDITQAASLDKAKSWVKELQRQANENIIIALAGNKLDLVADNPDKRAVQTADAEAYAREAGLLFFETSAKTAENVQELFTAIARKLPLDQVGPRGHARPGQRPGVSLAPESANTQVGGPCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0SI37</accession>
    <name>G0SI37_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0074370</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697689.1">
        <property type="nucleotide sequence ID" value="XM_006697626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SI37"/>
    <dbReference type="STRING" id="759272.G0SI37"/>
    <dbReference type="GeneID" id="18261475"/>
    <dbReference type="KEGG" id="cthr:CTHT_0074370"/>
    <dbReference type="eggNOG" id="ENOG502S8FX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031555_3_0_1"/>
    <dbReference type="OrthoDB" id="5326346at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="601" mass="65972" checksum="DB4C21E810BEA5A4" modified="2011-10-19" version="1">MDSLQVVVVASPFVNLTPLYEVDPDADVLLIVPPRNSSAVAPSDLLGVKPKQTSTAPPKPGVRIKVSSKHLALASKVLKTKLFGSGKLPKQPDGRVHLQLSEGFDSQAVTIIMNAIHGRGPRVPKSVDLDLLAQLALVVDKFQFYDALEVYADRWISRLAHTLPQSYNRDLILWIYISYVFRNEDIFASMTKIAALQSSRPIQTLGFPIRDKIVQSIDGSRQALLSRTLATLYQSLEELASGGLKPASCSHHGTHDCGDSLLLGELVKSLHRQHISLWQKPSAPFTGLSYASVAEGVASGLELYQQRQRVEDSEVLSTTARPSTASSSTSTRQVQTVWSQSEPKKEHVIKEDLPEWKKKKKHLASKSNANPAWGIINLPSVGPRLPPTPAASPELTYAKVAGLPDLPGAGAGLQADCWVRRVTGKLEGVEQLGREVEGLRLGRDIVSEDSNLKKGKMVQGDMPEVNSPDEGNLDTEDESQSGNLHKQTLKRRYESRIDDLKGEGLGKGEESQLEGIGSTGERSQRGGQSDNDNLQQEEMWRRDYWRGDLVQRLEGLSGREGDLSSTFLVKQGELNGNRPKGITYGLERRSHSHFAQKFPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0RY10</accession>
    <name>G0RY10_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">coproporphyrinogen oxidase</fullName>
            <ecNumber evidence="4">1.3.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0005000</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aerobic coproporphyrinogen-III oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.3" evidence="4"/>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691038.1">
        <property type="nucleotide sequence ID" value="XM_006690975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RY10"/>
    <dbReference type="STRING" id="759272.G0RY10"/>
    <dbReference type="GeneID" id="18254538"/>
    <dbReference type="KEGG" id="cthr:CTHT_0005000"/>
    <dbReference type="eggNOG" id="KOG1518">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026169_0_0_1"/>
    <dbReference type="OMA" id="VHANWRY"/>
    <dbReference type="OrthoDB" id="15318at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1500.10:FF:000002">
        <property type="entry name" value="oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1500.10">
        <property type="entry name" value="Coproporphyrinogen III oxidase, aerobic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001260">
        <property type="entry name" value="Coprogen_oxidase_aer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036406">
        <property type="entry name" value="Coprogen_oxidase_aer_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003727">
        <property type="entry name" value="PRK05330.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755">
        <property type="entry name" value="COPROPORPHYRINOGEN III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755:SF0">
        <property type="entry name" value="OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01218">
        <property type="entry name" value="Coprogen_oxidas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000166">
        <property type="entry name" value="Coproporphyri_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00073">
        <property type="entry name" value="COPRGNOXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102886">
        <property type="entry name" value="Coproporphyrinogen III oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS23796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="337" mass="38672" checksum="18CB9FC2469C310A" modified="2011-10-19" version="1">MATSSLAQADSKLREQEVSESSPMRLRMEKFVKEQQREIVKALEEVDGKPFRVDEWSRKEGGGGISCVLQDGNVFEKAGVGVSVVYGTLPKPAIIKMRANHKNIAEEGNIPDSLDFFAAGLSMIVHPKNPMAPTVHLNYRYFETAKPGDSSGNSGAWWFGGGADLTPCYLFEEDAIFFHQQLKDVCDKHDPAYYPRFKKWCDEYFYNKHREEARGIGGIFFDDLDEQTAPREKLFAFVQDALKSFVPTYVPIVNRRKDMEFTDREKHWQQIRRGKYVEFNLVHDRGTAFGLNTPGSRVESILMSMPLTARWEYMYSPEPGSREAEMEEVLRNPREWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0RY57</accession>
    <name>G0RY57_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA repair protein (Rad57)-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0005510</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691085.1">
        <property type="nucleotide sequence ID" value="XM_006691022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RY57"/>
    <dbReference type="STRING" id="759272.G0RY57"/>
    <dbReference type="GeneID" id="18254589"/>
    <dbReference type="KEGG" id="cthr:CTHT_0005510"/>
    <dbReference type="eggNOG" id="KOG1564">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013059_1_0_1"/>
    <dbReference type="OMA" id="GDGAYPE"/>
    <dbReference type="OrthoDB" id="1861185at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF66">
        <property type="entry name" value="RE19845P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="4">
        <location>
            <begin position="121"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="318"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS23843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="576" mass="62707" checksum="ECE09739F85BB6AF" modified="2011-10-19" version="1">MTDLLRVLPHFPIGPYARLLPVLEQHGLTTSDLLTLEAAEIGKRTHLPLLDIKRLCDAVLSALHADLGVVSTPKARSNTAGTVSETTVDEPGDGVGRWKQQQEQRKHKQQLKNTFANLISQWHTISTLDPTLDAALSGGIPIRTITEITGESGTGKTQFLLTLLLSVQLPPPHGLGRPAMYISTEAPLPTRRLSQMLSTNPVFQQPPRHQRPSLDRILSTSTPDLESQDHILTFQVPVEIERRNVGLLVLDSVAANYRAEFERAGGKQGSNMGARTAELVRLGMLLRELALKYDMAVVVANQVADRFPGEVFVPPPVPLSTAHRPAKHPRLQKVDDSPLAPRSKLPAPEPDTPETPANIPPPSSVPLPSSQLLPTTPTPNPAVKNSSTLPSSSTSDLKDERVQRQQQHQPAVLLLDHQQRWFTGWGDTPSSLYSTTGPLLKTPSLGLVWTTQLGMRIALFRKPRPAYGYRTPASRIDGNATHAAAVVARDGTMGIGDDYEAVVEKEETRRVLLASKGSSSGNSAWRRWMKVVFASHVAESGPGVEEAPGAVEFEVWMGGLRAVQKQGTGKKSSWGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZM4</accession>
    <name>G0RZM4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable endonuclease LCL3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Probable endonuclease lcl3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CTHT_0003480</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LCL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690894.1">
        <property type="nucleotide sequence ID" value="XM_006690831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZM4"/>
    <dbReference type="STRING" id="759272.G0RZM4"/>
    <dbReference type="GeneID" id="18254386"/>
    <dbReference type="KEGG" id="cthr:CTHT_0003480"/>
    <dbReference type="eggNOG" id="ENOG502S1U4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046484_0_0_1"/>
    <dbReference type="OMA" id="WAKVWRK"/>
    <dbReference type="OrthoDB" id="430293at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000029">
        <property type="entry name" value="Probable endonuclease lcl3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302">
        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="17">
        <location>
            <begin position="86"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="278"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGS23652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="294" mass="33144" checksum="1C426ED4A47F64C8" modified="2011-10-19" version="1">MLQMAADRDRQRCSGVTAANAKANATSPTQTTSLKDSIRAYLYQPQNWIAPILAAGVGIGLWSFYQNYLRRFPGSEHIAPSFFRRRSLLGKVTSVGDGDGFHLFHTPGGRLAGWGWLRHVPTDRKVLKGRTISVRLAGIDAPEGAYFGRPAQPYAAEALAYLESLILNRRVRAYIYRRDQYDRVVATVYVRTPPFFFPRKDVSLEMLKRGLATTYEGKFGAEFGGAKLERLYKETEAEARRQGKGMWSIEKPRLSKGFFNNALGRKNGPARGVVETPMEYKKRMRAEEKKGNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZT2</accession>
    <name>G0RZT2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0004090</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690952.1">
        <property type="nucleotide sequence ID" value="XM_006690889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZT2"/>
    <dbReference type="GeneID" id="18254447"/>
    <dbReference type="KEGG" id="cthr:CTHT_0004090"/>
    <dbReference type="eggNOG" id="ENOG502SEC6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032673_0_0_1"/>
    <dbReference type="OMA" id="IRSECRM"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14312:SF1">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14312">
        <property type="entry name" value="CREB/ATF BZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="328"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="461"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="360"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="461"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="485"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS23710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="555" mass="61082" checksum="486504F656C08D7E" modified="2011-10-19" version="1">MHPFRNSQADPLAEKARAKVQELVDDGLSPQLLLTAVLEKCNEFALQQSWQQVQSNLAAAGHIGLSASNDRLSVSTTSSKSSGRSSIMSTATTMSSASSRGGIGEVGGTQEFTVAASAAAAAPAPPPPPVPKPPAPPVKSSNRGASKTPGTYWCTFCNVDFQRKFDWKRHEDEFHERYKRYPCPDCNRVFWGANTFNQHHKNAHGCTTCPHADKVIKYTRRKTAWHYEEGCKKSEWNHSKVIYGLLHNPHVKQAWDELQDEKYGHLPKNQQPRIGWDPKTTGHAQGFLEGESPGNLQDLLEFFVAGRDDPKALAQKADECAIKVWPHQLRKDSSSASSSNATSSSPSRPFSEPAKPKTPVPKTSTKHLSSPDRPLPPDPPVYIDEPLPKKQRNHSPPAKIQTPFGSVEKPPLQPCIFDQAQSPSAVVTPISPFDQTMLDTTMSTPATESTSFFDFSTTQLLSHTQQPTSQPQQQPQQSPHPPQQPFQQPQQGHHQAPQLPQLQHQQQDLLLSPTVFDDWSSTAGTIVDPSIFTSVMALGPGWQTDLHQQHFGSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0S004</accession>
    <name>G0S004_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative calcium-dependent phospholipid binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0008260</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691356.1">
        <property type="nucleotide sequence ID" value="XM_006691293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S004"/>
    <dbReference type="GeneID" id="18254864"/>
    <dbReference type="KEGG" id="cthr:CTHT_0008260"/>
    <dbReference type="eggNOG" id="KOG0819">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012466_1_0_1"/>
    <dbReference type="OMA" id="ARMPNEI"/>
    <dbReference type="OrthoDB" id="2134400at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF107">
        <property type="entry name" value="ANNEXIN ANXC4 (AFU_ORTHOLOGUE AFUA_3G07020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="726" mass="82527" checksum="217486C6C9F31568" modified="2011-10-19" version="1">MSLQVDDSGHRPSRSHSPGFRYIDELERIERDTRDNRSRDRDSDRERERDRDRSRDHSRDHSRGDHAYTRDYNDYDYRSRPPPSPRAASAVADTLPPYPVTSGSFQDPSMTSVAYEYDRLTRWPGARDGDDDDDDDAYYETRRRATDYVYDPRDSRDRVGDGSYGSFGSFGSSPRHSRDSLFGRLDREAEKERERRRRKEKLEEDLAYGELPGPSRRERERVDTPPSPPTPPAPGTEAYAYAYSKPHDYGRPEDPRASGSRTNTPGPRDSGSKLGHGVGLSVSPPSPALRPVPLKSAMKQRDPSPQPPTARMSNLTLQIPGHHRTGSSSLSASSAPASPLMEAYHGTYQSMSPMPSPMLLPTSPGGQIAEPISPLASDIDEAEALSPGGNGSIKKKRTRRARFHDPVDDALRLAKALKGRERDPDTEPLIEILPGLTHEEVMALRAEYKKLVKTAPENKGVNVAKHIRMRLKDKDEQLMKACYTTALGRWESEGYWASFWYHGDKTRRELLIEALMGRTNEEIRKIKAGFRDKKYGDDLECCLRTELKEDKFKKAVMWVLEESRMEEVDRNGQPLPIDYDRVADDVQRLREVIKREKGGETLMLSIVLRRSDAHLREVLRVYKETYKGANFAKDALKKSGNLVGEVLAHVLNGIINKPLRDAMLLHHALTASRRDPLRKELVTSRLVRYHWDARHMALVRRAYREHYGHELVDAVRDATSVINDVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0S088</accession>
    <name>G0S088_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0009160</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691440.1">
        <property type="nucleotide sequence ID" value="XM_006691377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S088"/>
    <dbReference type="STRING" id="759272.G0S088"/>
    <dbReference type="GeneID" id="18254954"/>
    <dbReference type="KEGG" id="cthr:CTHT_0009160"/>
    <dbReference type="eggNOG" id="ENOG502SA4F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015255_0_0_1"/>
    <dbReference type="OMA" id="VMEAIVW"/>
    <dbReference type="OrthoDB" id="273070at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039136">
        <property type="entry name" value="NUFIP1-like"/>
    </dbReference>
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        <property type="entry name" value="NUFIP1_cons_dom"/>
    </dbReference>
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        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13309:SF0">
        <property type="entry name" value="FMR1-INTERACTING PROTEIN NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13309">
        <property type="entry name" value="NUCLEAR FRAGILE X MENTAL RETARDATION PROTEIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10453">
        <property type="entry name" value="NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="474"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="474"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="430"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="553"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="390"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="235"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="284"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="557"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="572"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="584"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="600"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS23249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="669" mass="72122" checksum="1930885AF01B9193" modified="2011-10-19" version="1">MSYNYGPPPPPPGPAPPAPSGSAPYAHPYGPPTARGGHSARGRGGPDRGTYHQTTTPGPSPSYPYGGQHPQSMYSPGAQPAAPYTGPHQPVYPPSQQHWTPSAAPATSQPPAAPIPPPGQNYQASYATPPQAYPPQHAPYGGHPQPPYGQHSVQPYNNGYPQSSFNAPPNVNQSWSGHPQPPSNTPYPGAGRARGAHNDRSAPKGPIVAPPIRLGFDAGNPSASPAPVSTHYPYGAPPPAPPAPYPVPPVTSYAPPPPVFLPTKPSFESRPGHGSRNLGRGGYHNNNRSKLHNNSMNNRHRAQNRSTGSSAPPQPQRSEVHSGGKKKKRRTNTLGLTPVENDAGSQADSDNDENEEERLNELYGLDAPNPQTESEIAAWIAERRANYPTKAKIAARRKAEEEQRLEARREKLRKKLEEVESTIKRKRALDDDGDDVRDRDATLSRSSTPSSDDEAPEVLSSRQESNVPPPPKKADTRQPCKYYSFGGNCGKKDKCRFVHDDELREKSVREQRENGGRLTLRQRLALNDKEIRDRACIETLIYLRQRNVLPPKKEVQAVTSTPSNENGDNKEPSSPASGGNASPHTASPESRTNQNSKDMSAAPSQGASGSSDREGKSLGFKIYPVLPEASSGMVIGDTGPTRGFGSKLCSWGRGLSQTERRVSQPQGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0S089</accession>
    <name>G0S089_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0009170</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691441.1">
        <property type="nucleotide sequence ID" value="XM_006691378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S089"/>
    <dbReference type="STRING" id="759272.G0S089"/>
    <dbReference type="GeneID" id="18254955"/>
    <dbReference type="KEGG" id="cthr:CTHT_0009170"/>
    <dbReference type="eggNOG" id="KOG3297">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073901_1_0_1"/>
    <dbReference type="OMA" id="LGPTLWW"/>
    <dbReference type="OrthoDB" id="10256606at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="RNAP_III_Rpc25_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA-directed RNA polymerase III subunit"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NA-bd_OB-fold"/>
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        <property type="entry name" value="RNA_pol_III_Rbc25"/>
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        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
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        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
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        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_Rbc25"/>
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    </dbReference>
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        <property type="entry name" value="SHS2_Rpb7-N"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
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    </dbReference>
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        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="7">
        <location>
            <begin position="9"/>
            <end position="62"/>
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    </feature>
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        <location>
            <begin position="77"/>
            <end position="190"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS23250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="191" mass="21988" checksum="2F94B0FC660BD791" modified="2011-10-19" version="1">MFILTKIADLVQIAPEDFRKQSYAALEDNINAKYANKVLQKIGLCICLWDILWTSEGLIGQGDVEFRMVVFRPFKGEVIVARISDQSPEGIHLVTDFFDDIFVPWTELPEGSEFEPTENLWVWKEDDQVMYFDNNEMVRFRVIAEDWHDQTPSKPTEAEGTEEAAQANYKPPYQIIGSMNGPGLGCCLWWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0R7</accession>
    <name>G0S0R7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0010990</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691619.1">
        <property type="nucleotide sequence ID" value="XM_006691556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0R7"/>
    <dbReference type="STRING" id="759272.G0S0R7"/>
    <dbReference type="GeneID" id="18255137"/>
    <dbReference type="KEGG" id="cthr:CTHT_0010990"/>
    <dbReference type="eggNOG" id="KOG2322">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058671_0_0_1"/>
    <dbReference type="OMA" id="FGVMSLY"/>
    <dbReference type="OrthoDB" id="7933078at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd10429">
        <property type="entry name" value="GAAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF50">
        <property type="entry name" value="PROTEIN LIFEGUARD 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS22627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="283" mass="31479" checksum="1956AEA719BB34C4" modified="2011-10-19" version="1">MASTAKYTPAPTEDPDVHHLYTQPPPSYQASTSYPATSSSAQDDIHLYGAPRSSLDNLPDDFKYGSCVADATIEIRTQFVRKVYTILTTQLVTTGAISALSFASEGYKGWIQSHPGMLYFSMFGAIGMLLVTFWKRHSYPTNLIFLSIFTIMEAYGISVVVSYYDTAVVLNAVLLTAGIFIGLTLFACQTKYDFTSWMPYLFFALWGLILVSLSAAILPYSSGFDLFLAIMTAVLFTAYIVVDTQLVMRHLHVEEEIAAAINLYLDILNLFLAILRILNNRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0S114</accession>
    <name>G0S114_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-glycosylation protein EOS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0011980</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691716.1">
        <property type="nucleotide sequence ID" value="XM_006691653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S114"/>
    <dbReference type="GeneID" id="18255236"/>
    <dbReference type="KEGG" id="cthr:CTHT_0011980"/>
    <dbReference type="eggNOG" id="ENOG502QTWB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043164_0_0_1"/>
    <dbReference type="OMA" id="HVTHQKI"/>
    <dbReference type="OrthoDB" id="2139606at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021100">
        <property type="entry name" value="N-glycosylation_EOS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28147">
        <property type="entry name" value="N-GLYCOSYLATION PROTEIN EOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28147:SF1">
        <property type="entry name" value="N-GLYCOSYLATION PROTEIN EOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12326">
        <property type="entry name" value="EOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="39478" checksum="2AD5F61CFFE2AFE8" modified="2011-10-19" version="1">MYHRAKPTAQQPPRADDAPGYGPGAGRVSGNLADQLSQHQQQHLQQPIHPSSRPRINPATATTTSANTPKNPTDHGAPLSRTTTNTSTGNKADLPTEPLQSTLLQPRVAVALGVSQKWYPLLFLCRLASIAPVILFGLPTVLRLLATLHLMYLDRVLDGGGALTKLTTRKGGADNGGGFAQGYKMMGTGFDPEFEARLRLTEMVLAIIWCFASGYLSFFFTDCLMSRWLLNYTPQATIVRLLTVDALNGYVTYWVLHLTGGFEDPRLVLPAWIVISSTLTVLYHITQRKINIRKETSMSISVFSIASFVSMVTLLIQLHSNRSDYPDIPLLNFARRLFHATGRLALRIMEYGDVTKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0S132</accession>
    <name>G0S132_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0012170</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691734.1">
        <property type="nucleotide sequence ID" value="XM_006691671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S132"/>
    <dbReference type="STRING" id="759272.G0S132"/>
    <dbReference type="GeneID" id="18255255"/>
    <dbReference type="KEGG" id="cthr:CTHT_0012170"/>
    <dbReference type="eggNOG" id="ENOG502RVVP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033919_0_0_1"/>
    <dbReference type="OMA" id="FSQRRAF"/>
    <dbReference type="OrthoDB" id="5234772at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="467"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="283"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="521" mass="57840" checksum="CEFD2D383E92097A" modified="2011-10-19" version="1">MTEIFFQSALAASKSQKLAADAAKIKSSCLESHSHQHQHSDTPSLLSCPPCYESLLDALRARYLGATFIKSTTETADPSTSATSSSRGVAATEEGEKEEKEWFSPRRPFLSDLAALIDSAREYQVSPQAIDERIRAERARWYAERVRGSLLRLLVEDPSGRGEVFEKLEDLAAGMATAAAAPSGPGGSGQGGVGDPIRLAEEIAERLRAGPLAPYEGSATVGERLASVTDPSERAEVLKQAFFANEDNSTVPADHQKYFSLLLHGGLSMDKVVDRILEDRQAAAGAREQTDKLNQRLDELRRARAAHELQKSRKAQRRESLAQQRVPEELYNLPACAVCGELPGTREFFVCSVCVILAEKGVLERPTVWCSGECEERGHASHTEQAHLCASASHCLQLHQHPDQPHSSPLDVHFCAECLTTLKQPTLYCTLACADADFQHHREEVHLPERRNLGLPMDEDEDQLEYLDDHDHDNDTNMTDGDHNPEQQQRKQYRARDITAVMTSLEEAVKEWEGRNRVRMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0S168</accession>
    <name>G0S168_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fumarate hydratase</fullName>
            <ecNumber evidence="2">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0012530</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. In mitochondrion, catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH. In cytoplasm and nucleus, involved in DNA repair in response to DNA damage: following DNA double-strand breaks (DSBs), translocates from the cytosol to the nucleus and promotes DNA repair by catalyzing the dehydration of L-malate to fumarate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691770.1">
        <property type="nucleotide sequence ID" value="XM_006691707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S168"/>
    <dbReference type="STRING" id="759272.G0S168"/>
    <dbReference type="GeneID" id="18255291"/>
    <dbReference type="KEGG" id="cthr:CTHT_0012530"/>
    <dbReference type="eggNOG" id="KOG1317">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021594_4_1_1"/>
    <dbReference type="OMA" id="AKWRAQT"/>
    <dbReference type="OrthoDB" id="1738025at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01362">
        <property type="entry name" value="Fumarase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000002">
        <property type="entry name" value="Fumarate hydratase class II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00743">
        <property type="entry name" value="FumaraseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00979">
        <property type="entry name" value="fumC_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444:SF1">
        <property type="entry name" value="FUMARATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="5">
        <location>
            <begin position="86"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarase C C-terminal" evidence="6">
        <location>
            <begin position="485"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00056821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS22778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="544" mass="58668" checksum="13A5AB5671712E63" modified="2011-10-19" version="1">MLRSVRIAGPAARGTATANVPRTVLRPLMSTCAGASTATKAIASYAGARPALLGRSAAQQFRQFHASIARMEEQKPKTRIETDAFGEIEVPADKYWGAQTQRSLTNFKINQPQDRMPAPIIRAFGILKGAAATVNMRYGLDPTIGKAIQQAAQEVADLKLIDHFPLVVWQTGSGTQSNMNANEVISNRAIEILGGVMGSKKPVHPNDHVNRSASSNDTFPTVMHIAAVLEIEGELLPALRSLRNALQAKVDEFAAKNIIKIGRTHLQDATPLTLAQEFSGYVAQLDFGIKRVESALPDLRLLAQGGTAVGTGINTYEGFAEQIAEEVTKMTGTQFYTAPNKFEALAAHDAVVQAHGALNTLAASLTKIAQDIRYLGSGPRCGLGELLLPENEPGSSIMPGKVNPTQCEALTMVCAQVMGNHVACTIGGMNGQFELNVYKPLIIRNLLHSIRLLADGMRSFEKNLVVGLQANEEKIASIMKESLMLVTCLNPKIGYDMASKVAKNAHKKGITLKESALELKALTEEEFDTLVRPELMIGPKPYKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G0S189</accession>
    <name>G0S189_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP-dependent RNA helicase SUB2</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ATP-dependent RNA helicase sub2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CTHT_0012740</name>
    </gene>
    <organism evidence="24">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ATP-binding RNA helicase involved in transcription elongation and required for the export of mRNA out of the nucleus. SUB2 also plays a role in pre-mRNA splicing and spliceosome assembly. May be involved in rDNA and telomeric silencing, and maintenance of genome integrity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the DEAD box helicase family. DECD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691791.1">
        <property type="nucleotide sequence ID" value="XM_006691728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S189"/>
    <dbReference type="SMR" id="G0S189"/>
    <dbReference type="STRING" id="759272.G0S189"/>
    <dbReference type="GeneID" id="18255312"/>
    <dbReference type="KEGG" id="cthr:CTHT_0012740"/>
    <dbReference type="eggNOG" id="KOG0329">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_0_1"/>
    <dbReference type="OMA" id="YAHVEPK"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17950">
        <property type="entry name" value="DEADc_DDX39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000111">
        <property type="entry name" value="DEAD-box ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000168">
        <property type="entry name" value="DEAD-box ATP-dependent RNA helicase 56-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="22">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="20">
        <location>
            <begin position="81"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="21">
        <location>
            <begin position="268"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="18">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00040402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EGS22799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="434" mass="49214" checksum="068A27394493892A" modified="2011-10-19" version="1">MSAEEDLIDYSDDELNNESTGPSANGKKADAAASTQNVDKKGSYVGIHSTGFRDFLLKPELLRAIADCGFEHPSEVQQTCIPQAMLGGDIICQAKSGLGKTAVFVLTTLQQVEPVPGECSVLVMCHTRELAFQIRNEYNRFSKYMPEIKTGVFYGGTPIQKDAEILKNKDTHPHIIVGTPGRLNALVREKYLRLGSVRMFVLDECDKMLDQIDMRRDVQEIFRATPQQKQVMMFSATLSDEIKPICRKFMQNPTEHYVDEDTKLTLHGLQQYYIALEEREKNRKLNELLDELQFNQVIIFVKSTLRATELDKLLRECNFPSIAVHSGISQEERIRRYKEFKEFNKRICVATDVFGRGIDIERINLAINYDMPADADSYLHRVGRAGRFGTKGLAISFVSSDQDREVLKAIEKRFEVALPEFPKEGVDASTYMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1F3</accession>
    <name>G0S1F3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sterol esterase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0013390</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691855.1">
        <property type="nucleotide sequence ID" value="XM_006691792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1F3"/>
    <dbReference type="STRING" id="759272.G0S1F3"/>
    <dbReference type="GeneID" id="18255377"/>
    <dbReference type="KEGG" id="cthr:CTHT_0013390"/>
    <dbReference type="eggNOG" id="KOG2624">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010974_5_0_1"/>
    <dbReference type="OMA" id="WRMYNEI"/>
    <dbReference type="OrthoDB" id="9974421at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000095">
        <property type="entry name" value="Triglyceride lipase-cholesterol esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="9">
        <location>
            <begin position="132"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS22863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="473" mass="53005" checksum="EB2E2F19DE9E0D75" modified="2011-10-19" version="1">MPLPFVGRLTFTEYIALIGSFMLVGIEAFVRLFTLALPTSLLDLLYAASQSVFNRLASPARTRPERRQSLTTAVRNATDFVDLCAVFGYTAEEHVVQTKDGYLLGVHRLAWRKGEEGARVNCGSAPGSIQKPVVYLHHGLLMNSEVWVCLTDEQRALPFVLVERGYDVWLGNNRGNKYSKKSIQWSPSRNEFWNFSIDEFAFYDIPDTIAYILDTTGQPSLSYIGFSQGTAQAFASLSIHPRLNDQVNVFIALAPAMSPAGLSNGIVDALVKASPQLLFLLFGRRSILSSAAMWESLLYPPLFCKLIDMGLSFLFAWRTENISPSQKTAAYPHLYSFTSTKSVVHWFQIIRTKSFQMYDDDVPSLLWGAGSGVGVGTTSTRRYTKVAKYPTKNIKTPIVLVYGGSDSLVDIEVMRRELPPGTVATEIKHYEHLDFLWASDVHELVFPRVFEALEKYAGDGEEKMMNTGRKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1F9</accession>
    <name>G0S1F9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative rho1 guanine nucleotide exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0013450</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691861.1">
        <property type="nucleotide sequence ID" value="XM_006691798.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S1F9"/>
    <dbReference type="GeneID" id="18255383"/>
    <dbReference type="KEGG" id="cthr:CTHT_0013450"/>
    <dbReference type="eggNOG" id="KOG4305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001083_2_0_1"/>
    <dbReference type="OMA" id="DMFYHPG"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041675">
        <property type="entry name" value="PH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057283">
        <property type="entry name" value="RGF3_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF1">
        <property type="entry name" value="RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15405">
        <property type="entry name" value="PH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23582">
        <property type="entry name" value="WHD_RGF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="6">
        <location>
            <begin position="945"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="1172"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="7">
        <location>
            <begin position="1383"/>
            <end position="1690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="218"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="309"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="425"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="502"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="554"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1113"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="120"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="322"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="425"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="562"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="591"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="642"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="661"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="699"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="716"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS22869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1742" mass="192795" checksum="8911E6E1B1E022EC" modified="2011-10-19" version="1">MAFRGDDTRRYGHVPPAQYSVAGAAAAQEPLTSYSARPPSYNSGDDSSFFDHTATRPQTHYSGTSGRGEEELFISSPASSPSAQPNPNRASYIPSSTSTTSAYQRQYQVPPPPPPPPPVHATTTTTTTPTTPNTTYNPQHFARSHSTSLPYHPHPRYGSSTSPTYTTPLVTNYTPPAYNPAAYANTPTTSTVPHRHSTIAGYGNYRYNNYSSPAVPQVSTTFVPPPPSSYGGSQPSSATSPSVPQRYEPALHSPQYSSASTPSAVSPQYEQPSYSYNPAQYTSSYAANGASPVSTASYPVTTSTAPYPMQNQIPVGPMYSSPDPNTFANRTTRSASQPPPLPSPPIYMSTTQQPLQRHPTNAPLPSRPDEVAEEPEWRTGGAESDIQATQDSLIQEIVSDLGISHPQSLNGAAPDVTADNRAHRYNSTSSRHTTDSGVNLHHSNSTSSRSNNGGAPLNYGWDSEESDPEGAAGLIAMRNDADDRRFGSLSFPTYMETPVTASASSTIPATSHRPSISEETFPEPSDYGGMDLGMYGGGYAGNLQYGTDVGLTSATESRRPLPDPYAQPAELPPFPDVSVDYGGTGGLQAPQERRLSFDEGEERVSVHSRRSSSDDPEKDDFPYDQMFWHPGLTNRPLPAIPTAPESSSQASSQPAVTTASYSQHTYSLSADSTLPYPPGTPDLYPSQGFAPQQPVERSVSLNNHSTTPQVQAPARSRTDANEERRRAKYMSQPHLYGPGASYGTYGADVASSLAAYDMITLPTGRRKKFVPSKLTSADFKRCAEPWALSGVTAWIREMAEGEPDLKRKTIEEGILKLFCAKVPTMNVADAEQLSANVVDSMFAAGILLPDEEWVKFGSGELSGVLWQLTGSGCYAPKLHDSEDSVPRLHDNGIPIRCYSHHCGRTLKKMNLDNLKVEEEPPILDWATFYGLKKEDIEGKPKKEIERQNVLHEIVTGEEEYMGQLNVLRNLYRDQLRSWQPPIIAENRMEKFIDAVFGKVDAVQQINKEHLLAQLKYRQKEQGPWIVGFSDLFREWIRKARPIYIEYCANYPYAEYMIKKEAARNLLFRQFLEVVREHKLSKRLEWRTFVKAPITRLQRYGLLLETVKKNMIGESEEKTNLEKALEEIKKVTHECDEKVAEMEKKVMLLELQHMLVMRPGFQSVLNLDHLGRELLKQGELQRQGSKGVRWVDTHALLFDHYFILAKAFMAKDGSGKKYDVSKEPIPMPLLFLESTNDEPVAKQKSLTAPLTRTAVTGAGSQLMSKSATMSEKPGADDDGKIIYPFRIKHLGHEIYTLYASSAQERTAWCNAIIEAKTRHARALHAQNAEPFRLRVISDCAFAYDSTSPMGRQPTVPIRDTPLDRAIREMEKTYGPGRGPPPVCRATVNCACAFNMFGKSIIAIGTDYGVYISEASNPRGWTRTVQLPKVTQIAVLEEFSVCLLIADRSLISYPLDIIAPVSAFPPPTYDSPRRAPQKLAKDVSFFATARMKDRMLVFYKRKEGMHNTFKVLEPVFQRSTEKRSRLFGRRSGGTTETFRDFDEFYIPAECYSLNLFQTYIAVSTSKGFELLTLDKKVPQSIPRELNQPEIANIASRIKDTIPLGMFKLNDNEFLLTYEDCAVYVDKHGEISRTLIMEYSGKQKKAKAATMFGQYLLLFNDDYVEVRNAENGRLRQIIAGRDVRCLDYGYRGPTGSGGAKLPPAQALAAAAKDSKGTVKICMSHPEVSGGQIVLEMVLNDGHVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1K4</accession>
    <name>G0S1K4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosomal protein s17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0013920</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691906.1">
        <property type="nucleotide sequence ID" value="XM_006691843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1K4"/>
    <dbReference type="STRING" id="759272.G0S1K4"/>
    <dbReference type="GeneID" id="18255430"/>
    <dbReference type="KEGG" id="cthr:CTHT_0013920"/>
    <dbReference type="eggNOG" id="ENOG502QU23">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029378_0_3_1"/>
    <dbReference type="OMA" id="PDNTYYA"/>
    <dbReference type="OrthoDB" id="2336871at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053216">
        <property type="entry name" value="Appressorial_penetr-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34587:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34587">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408829" description="Ribosomal protein s17" evidence="2">
        <location>
            <begin position="20"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="497" mass="52011" checksum="098879FF011BC59C" modified="2011-10-19" version="1">MLMKNALTALLGLAVATEAVSIQQLRSVGLARRQDQGQVQANRFGNNRFGNGGFGNGGFGNGGFGNGGFGNGGFGNGNNNNNNNGNNNNNNGNNNNGNNNNNNNNNNNNNNNNNNNNNNAASVTCLAPNAIQTGSQQTGQNGAVPADGQVNSATDPANFINFCAGQTLTNGLQNRDGSCNGIPMGKIPSVNRMVSTVILNPKNFDDLQELTTFNIVLQIKDMQLGSFTNATSTYYAAPQDLNAAGQIIGHTHVTVQDTGNTLNPTQPLDPTQFAFFKGINDAGNGQGRVQAEVTGGLPRGCYRVCTMSSASNHQPVLMPVAQRGSQEDCRYFSVGGACATGNNNNNNNNNGNNNNNNNGNNNNGNNNNNNRNNNNNNNNNQGNNNNNNGGNRGNNRNNNNFNNNNNSNNNSNGGNNQRAAFNSLGGINPPEITSTNDPNRPFAVAGNTFASRADAVQRACAIQNNACADAVNSGALPGVTVPQCNAQEQTCRQALGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1K9</accession>
    <name>G0S1K9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Mediator complex subunit 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0013970</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SRB8-11 complex, which itself associates with the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 12 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691911.1">
        <property type="nucleotide sequence ID" value="XM_006691848.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S1K9"/>
    <dbReference type="GeneID" id="18255435"/>
    <dbReference type="KEGG" id="cthr:CTHT_0013970"/>
    <dbReference type="eggNOG" id="KOG4522">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002034_0_0_1"/>
    <dbReference type="OMA" id="YPVRPWE"/>
    <dbReference type="OrthoDB" id="20828at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057344">
        <property type="entry name" value="ARM_SRB8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019035">
        <property type="entry name" value="Mediator_Med12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46567">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46567:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25326">
        <property type="entry name" value="ARM_SRB8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09497">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01281">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med12" evidence="14">
        <location>
            <begin position="336"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="170"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="836"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1361"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1509"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1759"/>
            <end position="1809"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="989"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="836"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1361"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1764"/>
            <end position="1808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS22919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1875" mass="205392" checksum="1E533EBA170284E0" modified="2011-10-19" version="1">MTSRPPLGVQQPRPPQHQHTHKLPTSSLSQRSAPHQHQHQHQHYLQHQQQRVLAQQPPPQQPLPHQALQQHAYPLQQHAHFPPQSQSPVRRDVNGYDLTTTPDFGDGAAAMPSRQTLHRRPGSRLKLEIYNSDPADPTAASTILHDTSLTESPSCVADSKPFTPSRIMPPMDPSEMGDMSPDPSTHMHTADLDAPLPMPARPARINTVLPQRPAAQPPAASNTTSKKDSRPKPFTVEPPAAAPSYPVRGNDQQKTTVAYADFFPWTGNGPEDQFSEHVIRNGYYDKGIFSTAETQSAKATLFPALKHKTGLTALSSVFAAVLGQRRHNGQITTPSTFKPPPRVTLTDTKRELWLKDLANPAISLRRLSRTIPHGIRGKVLLEQCLNKNVPTDRAVWLIKCVGANEIRATKRKGVGTLVVGGESRWIKDWTISVEQFIEQVYFGFDEDDWKAKVHYTTRLAAHLYAEHLLDREHYSEWLVSSLENSSEARLPMWMLLTQLYWSDLLKLRKYGRRLVTALISHHHLIYNHPDRDILNPLLKTLTDCLNTLILSSPENFVCPAAWIKYRDALQACLPAGDEARRNSFEAINLRNEQLAASANRSQPAARHILVGMLDGTLHAPMPSDLPSQCWSVSQDKPALARALLEWCTSLYRPGLAKVYVTSKILQHWSTLGFDVTLAVLDFLCDDPLEEQPRKNALYHLVCELVRASLFAVSRYIRWLMGRGGVRRPEQVAPDGPAATRLLAEMPPCVLTSSERNLRSGILRRASYSVADEAENTVVAIKHLRYTFGMPMPDVQPNDPIFQRPPMAMAKLTKRISKASRTLKGEVGSWLRASLASSSSSSSSSSSSFSSSTGDKEKGGPQLPDVSPSVFYGMRSVLEAAEDFTILADVLKTLTKHCTVDILPAIADTVNRHFFIFSALDAASPIFLALHQRFKTTAVREQGITLRPLLVSLVSLGARIPGMEDVVARLKKDLALTDRHNPVDACSPVSDNMVSRLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQDDASDLHDEIEKLLAGGSSLDRNTMERLFQTIVQRLQAAWGGAAATKQRAYSTLLGRLRAFDAQCFDGLMVKWLMYLRALGSRPSVLRIFPLLVSVGCLEFGTILATASEFPTAGAGQQRVPVPPPATLAGGVPQVVQITYRTRYMQQVLMLLTAPVPQDDLLTADEAYRFLVLQDQAVRDSPKEVLNLIFLALAEYSYARAQNDLEGLPLDADYVQELLFELLKRLVLRDATGVARALSVRSTNPQVMARIDWMTTKLLIPTAAAPQTTRVSFEQVLELTNEFTLPFCQVKLALALSLSNNNNNNNNNTTTTTTGEDGQEQQTSHVELLANAMDKAIAAGNVAWVGMLSSLSPDITQHLKARAQSRFLELLPSPPGKATGSSGRVAADQASLEQNLRMAENLLSVMDAIMRGGSNATSPIPPGGSPRQAQLSPAVVDKLVDLWEILASPTSQPQDTKSEDTPMGNTPTVGVDPETKASLLLYHLPLLLNLLTLHNNTQSSLDFSRQPADLRAKLLIACAGILHLLDHAVDLFELSRPPGPDNSASSSTGVIHPLPAEGELPAELAFPHPAQHGTVGGHDQGQDRQEKHTALARAVANLSRRVFDLACLLADNLPEEARLTCVRAVGSGGVLALDGRLRYVLSVPWGVGFDVGVAGLQSGGQQQGQGDGAGSVFTAGGSGGGGMGIGFGGSGGGLVLCHRDSGGAKPSSSASAPPGTRNPTINNNTNPNSHSHSHSNSNSNSNSNISGTGTGTGSMCVLLGTPISLWGLDRPGGAATERFSVFHFRRWEALSEPTPVVGENDTALSLGLFEARKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1L7</accession>
    <name>G0S1L7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative multidrug transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0014050</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691919.1">
        <property type="nucleotide sequence ID" value="XM_006691856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1L7"/>
    <dbReference type="GeneID" id="18255443"/>
    <dbReference type="KEGG" id="cthr:CTHT_0014050"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_844681_0_0_1"/>
    <dbReference type="OMA" id="LLWERPP"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF43">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="294"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS22927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="329" mass="34301" checksum="90AF978874568ACD" modified="2011-10-19" version="1">MGELIAGRAVQGIGGSGLYSLAQVCLLEQGPSRPEAVGALVGITLSISVTLLSGFVYIALVIKIPEQLQLIHGDNALWAGVHLLPMLGACAFGSFLGGALSKQSNLTSQTLVAGNVLQVAGLAAILGLSHRSDDGALGLHLLLGLTALYGLGVGLTFAACTMIAAIEACEGDLAAAQGAVAQARVFGGALGLATCTILFSERLQRELGSNGSLLGREELAQVLRNLMAVLNLPDGVRHEVLTVYLNAFEQQIMIMTVVAVVALVLSLGTYRRSGPRQVIGVMVRHQELAAARTRGGDDSWRRGVKGSDGRMRGEAETSPLSSIRPFIRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1S7</accession>
    <name>G0S1S7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable aspartate--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0014660</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691979.1">
        <property type="nucleotide sequence ID" value="XM_006691916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1S7"/>
    <dbReference type="STRING" id="759272.G0S1S7"/>
    <dbReference type="GeneID" id="18255504"/>
    <dbReference type="KEGG" id="cthr:CTHT_0014660"/>
    <dbReference type="eggNOG" id="KOG0556">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004553_2_1_1"/>
    <dbReference type="OMA" id="WVHEIRD"/>
    <dbReference type="OrthoDB" id="372395at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04320">
        <property type="entry name" value="AspRS_cyto_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000038">
        <property type="entry name" value="Aspartate--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF1">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="286"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS22987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="598" mass="65831" checksum="B800AB016C594723" modified="2011-10-19" version="1">MADQQPTNPVPPPAEAPKTEPAATPAPAVPDGTLAGTPAPAPGGEGATISKKAAKKAEAKAKKEAEKARRAAELAAKQAAANAAQSEDNAKENYGPESPEKQISPDAIEIHLKDIGEEHVGKTVELRAWLQNARMQGAKMVFVELREEGNWSIQGIATASPEGNPVSRQMAKWIGSINPESFVVVEGTVAKPAVPVKGCTVSNYELHITKCYLHAAAPAMLGMTLAAANRPITNFSDEEQQASVEQKVEKLSISEPAGIPAASMLTHLDNIVMHKRSPLQQAIADIRAEMKQLYREYLRSQGFKEFEPPCLIGAASEGGANVFRLPYFDKEAYLAQSPQFYKQIEIAGGRKRVFSCGPVFRAENSNTPRHMTEFTGLDMEMEIKKDYHEVLDVLENCLLYIFRNIKERCAKEIALVRSVYPCEEFLFPEPGKTVRLTFAEGQKLLREEGPEEFRNVRDDEDMTTPQEKALGALVRKKYGTDFYTLDKFPESARPFYAKEDPANPKVTNAYDLFMRGQEICSGGQRINDPVELEARIRTKGIDPNSPGIKEYVDIFRQAGVPAHGGGGIGLDRVVAWYLNLPSVHLAAYYPRTPKRLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1T5</accession>
    <name>G0S1T5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-rRNA-processing protein IPI3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0014750</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="9 10 11" key="2">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e57984" last="e57984">
            <title>Structural insights into coordinating 5S RNP rotation with ITS2 pre-RNA processing during ribosome formation.</title>
            <authorList>
                <person name="Thoms M."/>
                <person name="Lau B."/>
                <person name="Cheng J."/>
                <person name="Fromm L."/>
                <person name="Denk T."/>
                <person name="Kellner N."/>
                <person name="Flemming D."/>
                <person name="Fischer P."/>
                <person name="Falquet L."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="37921038"/>
            <dbReference type="DOI" id="10.15252/embr.202357984"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.90 ANGSTROMS)</scope>
    </reference>
    <comment type="function">
        <text evidence="1 6">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the WD repeat IPI3/WDR18 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691987.1">
        <property type="nucleotide sequence ID" value="XM_006691924.1"/>
    </dbReference>
    <dbReference type="PDB" id="8PTW">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.91 A"/>
        <property type="chains" value="CT/CU=1-437"/>
    </dbReference>
    <dbReference type="PDB" id="8PV4">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="CT/CU=1-437"/>
    </dbReference>
    <dbReference type="PDB" id="8PV6">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.94 A"/>
        <property type="chains" value="CT/CU=1-437"/>
    </dbReference>
    <dbReference type="PDB" id="8PV8">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.91 A"/>
        <property type="chains" value="CT/CU=1-437"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1T5"/>
    <dbReference type="EMDB" id="EMD-17879"/>
    <dbReference type="EMDB" id="EMD-17953"/>
    <dbReference type="EMDB" id="EMD-17955"/>
    <dbReference type="EMDB" id="EMD-17957"/>
    <dbReference type="SMR" id="G0S1T5"/>
    <dbReference type="STRING" id="759272.G0S1T5"/>
    <dbReference type="GeneID" id="18255513"/>
    <dbReference type="KEGG" id="cthr:CTHT_0014750"/>
    <dbReference type="eggNOG" id="KOG0646">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025946_0_0_1"/>
    <dbReference type="OMA" id="GVNARIY"/>
    <dbReference type="OrthoDB" id="756370at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000929">
        <property type="entry name" value="Ribosomal assembly complex component Ipi3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045227">
        <property type="entry name" value="WDR18/Ipi3/RID3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763">
        <property type="entry name" value="WD-REPEAT PROTEIN 18"/>
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        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
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                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
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        </source>
    </evidence>
    <sequence length="2507" mass="279523" checksum="70FFEE19C6FAF482" modified="2011-10-19" version="1">MYSPSSFRRFDRYRDRPVDHGRGRPFTDPNDPRSRYTGSRYDGSDRRSRSPPPPRDRSPYGDRNDRGGPRYSDADRGRPPVEPRGNAPSFPMGRDSFRDSLSNIQPPRGPKALMDPPSGPRGGGFVGDFRGGRGGRVGLRGRQWRDDSRDPGGRDRDDYRDRPHFRDERSREREREREREQRERERDRERERERERERERERERDARDRDRDRDRDRDRDRDWQRDQRDRPDFSRPRRPSPPPLRARSPPPTRDFRDARDARDIRDARDARDAPLNVDAERARRGSRDGPLSAGSSNSDQMFSPSPFRGGFARGGGRGGGGIGTGGGGRGRGDWDQRPGRDRAPFYDDRDRFPRSRSQESRWGRDQDDRDRRDTRYPDTARDSRDDRDVRDNQRDIVRPKPERPPHEPQSAKDVSPPPLAPSAPAFGSVPSRQSTAAEIQSLTGKPPPTGPRAMTEEKAAGVPHGPGSDRPPPAGPSKPQLPDGPLIPAGPRAQQKQQRSSRQWINPSLNAKKVDILPGPRGPHGFGPQPPQRPVGYRPDFSHQGDKRPRSPDGHHVATGANEIVIKSERIPVKPPVANREPLKPAPGDANVAVTGAKVAERKREERQDELQTSPTAAKRPTAEGSAEEPRKVEETKEPEVIEKRRPVILIPARRIQLPPKERLPPLSDESSESDEDEDMDMYFEQQISKVEAELNKIEDAIDKAPMAIIRRYATAVHEAMLSVVNDPVTLTSLLGGIPEGFTFPCPKPATEKADEEMPDAEPELPSQPQPQPQPQPQPQLEREPAKEKEKDKIQDEQEPQQLQPQPQVVELSPAVSREPSVLPTIEIEEKESAAHVPPEPQPKVEEMEVESLAPVPSVKEEKQAAEEEKPAEEAQQTIGEDVEMQDAPEEPQLAMPVPRRSVSTAEVASADGEGEAKRSLFAPTFNQVETTEPSTVSADDQSEDRTEDDASVYGSVEAVRQYSATPPTDELPVYNVKPWWKSRRVKKICEENPEFSKFLMGHIREQAEQTKQKQQELREKYAKDYEAYLRFTQSDDPAAVKAREYMALGSKSNGESKPEGGRRAASRFSTELDLDYAMQQSMKEYQEKQEREERAQKEKYRSEKEAVIPEMFWTDREKEQAAFRDTSGLLPLEKLVSAWQVVPWHNNFTEEEEEKFEKAYLEYPKQWGKIAEQLPDRTFGTCIQYYYAKKRELNLKEKLKKQPRRRKKGGRTKQKASVLTTENPEGEGEDAAAAANQEDNGGTGERRRPPRRAAAPVFTSEVNSNVESEGNTPAATPGGRRRAGTVAARVGRRRLKKRRPRGAKQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQAVQEAGAVPIAATLATKAGRSRANSRAQGPEWASPQAPFLSGTFEGSAQMPPMSTGTERPMPSIPATIPEHVMSMSGPPSLRPEPPPPPAAPTMVAFEMASQSTSTAPERIRTPQQASSYWSVSETTDFPALLRAFGTDWAAIAAHMGTKTATMVKNYYVRQTKEGGKPEWEQIAMEADAKRARGEKLPAPPTPTQGPRKRYEAPAAAHRPLAAAEPEETAPVKTETSAQNPPYGRYQVPIAQAAPVSHPLVQPAQSAMSAPPLVSSAAPQQPPLPGPTASVSRAMSPHASHALRPPAPAYVPYPERAEIDSKVAQSAAQTQAQAQAQAQQQQQAARMSQKPPVPAGASSMPPVSEPMTRPAPERSWQTDISMQFSLLSQQNELRNREARERELRERELRERELREKELREREMREREILEFTQQQQQQQQREPVGPGPQPVDRAPPLRGLKQEHESGMHRAESPYPPYQPTHQHHRSLSSRIEPAAPLSRPQQELPRTVMPPASQAYGAMRSLLSEPVPPQQAPTGSITTERPMSSMQRLPVSMQEHYHGIPTSAAPPAPPAQQPPAAQPTPPPVSRAPEPRKTSSLMALLNDDPPPAPPAPTKRVTDVTAIKQSSPPPPPPQSMVRQPPPPPPPTSAPIVARREPEPAYAYGRSTAQTAIPPLKPYHNQSPQPQHTRVPSSGMVPALDAATERDPYYRHAYSSHQSGASNSPQLHPTHHYAQQPQQQAATMGGYPGQASYPPPRDPRDPRDPRDPHGSHMSSPTTQYAAHPSTSSAARERERDSVWISSQQRPLQPPSLHGQQQQQQSPWMPSQKPPAAQSAVPTQSAWGAQHGGMPMSTKPSQQQHHTWQSPAPTPQPQHQHPLSNLRGDPPRTTGVYAAAHDVSSPTMAPHHRSTGSIGGGAGSSLSSAAGSRYPPPAGPGAPQDPTRRVAEPQPAQPLPSAAGQSQPYARYANTPGPAQQPREPPPTVGGPRSYTPVGSGYAVAAPPPPQQAYAGMSAREQEAAAALRDVQMREQMREAQMREAHMRDMREAQYHRDAQLREQQQQQQMLEVQRREAQYREAQYREAQQQQYREAQFRDPASAAQYHDLQMRDAPLPQDALPGDPRDPRLSREEQIRQAQLREQQHYQQQQQASGAVGLLGRGLRPAPRPGPEGGVYDREGRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G0S240</accession>
    <name>G0S240_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kinetochore protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0015890</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS23100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692092.1">
        <property type="nucleotide sequence ID" value="XM_006692029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S240"/>
    <dbReference type="STRING" id="759272.G0S240"/>
    <dbReference type="GeneID" id="18255627"/>
    <dbReference type="KEGG" id="cthr:CTHT_0015890"/>
    <dbReference type="eggNOG" id="ENOG502QUWX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023691_0_0_1"/>
    <dbReference type="OMA" id="STIESKW"/>
    <dbReference type="OrthoDB" id="2420947at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025212">
        <property type="entry name" value="CAD_CENP-Q"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13094">
        <property type="entry name" value="CENP-Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="487"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="335"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="632" mass="69542" checksum="293D06624273ADF3" modified="2011-10-19" version="1">MAPSGPNQKKKRGRPPAAARAAAASQQQPKTKQSEKADASMSSSPELRQQRRQETRQQQQQEPSSPVQEETGRRTRAQKRGSDDSPAQAQKQGAGTKKTARATQEVEEPSHSVPKKRGHPPKQSDEQEGESRTEDRPSKRVRGEQGEKDGGREKKGSARDTKAATKQAQGATAAEEEGQPARGGRRKAQTQESPAQVPKDRDAEGEKQISRRSRGRKKEAEKPAEQPSLAESVPRRGRRQAQPAQEEPETEEEAAPRRRRRGRQSLAEVPVSKVQNQAPSPAHEEEAQGKTERGSGRPSRTSAASQDEPEPESSRSKPESSKPESPAPRTQQPLAEEEEQEPSSEDEELLDPLEKHRHLAPIPRNIPRATITARWKPLDGASIAAVDTIVSDAARTVLHRLRDRDVRHAQAQTILKAFATRLRGKLSKGIPFPPSAVGPSYSATSSAKGKKSTGKEGKAAMVEFDFEQTVEAIRRAERALDPALHSVALLERELSREEAALEREYKVLKTLETNAKAEAREWRERGKREHVLLVGGPGFGAAVGEKDGKEEGEKLEIVGRREGEAVFKDLQNDDELFALSQQVVNHMESIRSNLGQIDGVLPAIERSKAALQATLAKYLDREQYEQVVLGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G0S299</accession>
    <name>G0S299_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">DNA replication regulator SLD2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0016480</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Has a role in the initiation of DNA replication. Required at S-phase checkpoint.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the SLD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692151.1">
        <property type="nucleotide sequence ID" value="XM_006692088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S299"/>
    <dbReference type="GeneID" id="18255686"/>
    <dbReference type="KEGG" id="cthr:CTHT_0016480"/>
    <dbReference type="eggNOG" id="ENOG502SCF7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033089_0_0_1"/>
    <dbReference type="OMA" id="AVRMPQK"/>
    <dbReference type="OrthoDB" id="8775810at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902977">
        <property type="term" value="P:mitotic DNA replication preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22289">
        <property type="entry name" value="RecQL4_SLD2_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1460:FF:000001">
        <property type="entry name" value="DNA replication regulator Sld2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021110">
        <property type="entry name" value="DNA_rep_checkpnt_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040203">
        <property type="entry name" value="Sld2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28124">
        <property type="entry name" value="DNA REPLICATION REGULATOR SLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28124:SF1">
        <property type="entry name" value="DNA REPLICATION REGULATOR SLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11719">
        <property type="entry name" value="Drc1-Sld2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="28"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="172"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="347"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="564"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="113"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="242"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="350"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="414"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="468"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="503"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS22132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="585" mass="64307" checksum="B2B497CC06E1D60F" modified="2011-10-19" version="1">MDEKSRTSIESESLQLRVELKKWEADWAAAHGGKKPDRSDIKQNPEIAQKYKRYNKLRDLLTGKSQPAPKAEATHGHHHQQSHSEQRKRRSSDAAMPPPETPSKRSKLIQTPRKVQQYSTSAPNISTGSETPSAATMNQEPAPVLPSYISPTPQKDGRVLGLFDLLGRTPSASVVKSSGDAPSMAAATPSKHRDATPLQVPLNTDGMTPTTARFAHTPRSAVKHHASDAGIPTPLRERNDRGNSNNQLLFKTPSTNRVSKDTASTPKSATPSFLRRRNAPDYKGALLGTMDEDEENEESGVNGVAGTGGWKKRLSALRLPRKLVPVGKGLSSVVAGLRKMEDEMFAEEEAAAREMEREEAEKRKQAQAQQAEDQAQSQPQQTAVAPSAEVPDSQTIEKLLEEEKPAGGRLLSGFDDEAALDSPDELGDDQSQQTRVWKKKGQKRQTRLVRMRPTRVRRPTAQTVTPPGEEDDDEDDDELVPETQAQASGGNPEVEDGLRSDEEGSDEAFEESESENDEEEEDGKKKKKGKKAAAGDTTTGKDEDIVKKAVRKVKATAHANFRRLKLRNSGAKGGPAYNSRWRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2R6</accession>
    <name>G0S2R6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0018200</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692318.1">
        <property type="nucleotide sequence ID" value="XM_006692255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2R6"/>
    <dbReference type="STRING" id="759272.G0S2R6"/>
    <dbReference type="GeneID" id="18255858"/>
    <dbReference type="KEGG" id="cthr:CTHT_0018200"/>
    <dbReference type="eggNOG" id="KOG2893">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037132_0_0_1"/>
    <dbReference type="OMA" id="KQVLRPW"/>
    <dbReference type="OrthoDB" id="1306014at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20908">
        <property type="entry name" value="SUF4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000354">
        <property type="entry name" value="C2H2 finger domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215:SF0">
        <property type="entry name" value="BUB3-INTERACTING AND GLEBS MOTIF-CONTAINING PROTEIN ZNF207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215">
        <property type="entry name" value="ZINC FINGER PROTEIN 207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="9">
        <location>
            <begin position="14"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="286"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="298"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS22299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="344" mass="36867" checksum="003F5E34E8EAEFB1" modified="2011-10-19" version="1">MGHKKKRSHPDLEELLARPWCYYCERDFEDLKLLISHQKAKHFKCERCGKRLNTAGGLSVHMNQVHKETLQCVENALPNRSGLDIEIFGMEGVPEDILQQHNQRIIQNFYQAQAERAAATGNPPRGHAVQGPAKKIKYETPEELKKRLAEHRAKFAAQKAAAANGTAPQVPQADGAAAAPAPFPAAQPPAYPYPAMPPTVPGYPAAAIPPFPPTAPAGVYPAPGAPPVPGAPGASFPLPARPPGAPGAGAALPQRPPFYNGAGAPGEGPVQKVGGDDIDQLIRMAEAGIKPQAQQQQGEKKEEGAAAGEKKKKEVRMVYADTEVSPEEKMALLPRYRWVEEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2T0</accession>
    <name>G0S2T0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0018370</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006692269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2T0"/>
    <dbReference type="GeneID" id="18255875"/>
    <dbReference type="KEGG" id="cthr:CTHT_0018370"/>
    <dbReference type="eggNOG" id="ENOG502RS8P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_487607_0_0_1"/>
    <dbReference type="OMA" id="TMMESMH"/>
    <dbReference type="OrthoDB" id="4587526at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="586" mass="64650" checksum="2EF3D03AAEAAC183" modified="2011-10-19" version="1">MPPKHEPIMLWGFCFSTQQQKMSFNQSWACAFHTSWYTNESHPMWDSIDDIQKRREIRYGNNIYVLFRALLHLRRFWGQDSLWSAVAKGFNTSSSVVRATAEALTEARRAQRVKKSRDVSDTARAADEWIDFVDSQPKGLRVLSDPEVYKVAEAFFKEQEKKHLNAARVPTDPRRSQAHLAAQYIQAAQMKEDEEVSPPLSPRLFSPLLPPAPMSTVKQEQREEVKGVNPPRGPRKRAASPAPLLERSPKQRKFSMDERAPPTGPAAERQRPVPQSYRPQYDAEPRRASRQEDSGHVETSASRKSYSSSEDIILLKARIASLEKELAEAKEKANSQPHSHANATQAQQPASQAVVVATKPLDETVTSLQSDMATVTNVVGTMMESMHVIVDSLNLLRDDITGLSGQQKELASAVAGVTSAATKEGSVAAITNGVSDGGEIEKLLGPIQTLVEGLATLRQEVAELKKQPPSQQPPSGSTATLEALLHQQTAHIAKLSTQVNALQSRMQAQQALFTTPPQTLRQAFALAQLDLKKHKTVIEGFYSSMGHNASRHTMEQTANLLGAIQHGLGVIRESGLVGYGQGREAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2U4</accession>
    <name>G0S2U4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar protein 56</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0018510</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2017" name="Nat. Struct. Mol. Biol." volume="24" first="954" last="964">
            <title>3.2-A-resolution structure of the 90S preribosome before A1 pre-rRNA cleavage.</title>
            <authorList>
                <person name="Cheng J."/>
                <person name="Kellner N."/>
                <person name="Berninghausen O."/>
                <person name="Hurt E."/>
                <person name="Beckmann R."/>
            </authorList>
            <dbReference type="PubMed" id="28967883"/>
            <dbReference type="DOI" id="10.1038/nsmb.3476"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.20 ANGSTROMS)</scope>
    </reference>
    <reference evidence="12 13 14" key="3">
        <citation type="journal article" date="2019" name="Mol. Cell" volume="75" first="1256" last="1269.e7">
            <title>Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration.</title>
            <authorList>
                <person name="Cheng J."/>
                <person name="Bassler J."/>
                <person name="Fischer P."/>
                <person name="Lau B."/>
                <person name="Kellner N."/>
                <person name="Kunze R."/>
                <person name="Griesel S."/>
                <person name="Kallas M."/>
                <person name="Berninghausen O."/>
                <person name="Strauss D."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="31378463"/>
            <dbReference type="DOI" id="10.1016/j.molcel.2019.06.032"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.50 ANGSTROMS)</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692346.1">
        <property type="nucleotide sequence ID" value="XM_006692283.1"/>
    </dbReference>
    <dbReference type="PDB" id="5OQL">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="T=1-523"/>
    </dbReference>
    <dbReference type="PDB" id="6RXT">
        <property type="method" value="EM"/>
        <property type="resolution" value="7.00 A"/>
        <property type="chains" value="CC=1-523"/>
    </dbReference>
    <dbReference type="PDB" id="6RXU">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.50 A"/>
        <property type="chains" value="CC=1-523"/>
    </dbReference>
    <dbReference type="PDB" id="6RXV">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.00 A"/>
        <property type="chains" value="CC=1-523"/>
    </dbReference>
    <dbReference type="PDB" id="6RXX">
        <property type="method" value="EM"/>
        <property type="resolution" value="7.10 A"/>
        <property type="chains" value="CC=1-523"/>
    </dbReference>
    <dbReference type="PDB" id="6RXY">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.70 A"/>
        <property type="chains" value="CC=1-523"/>
    </dbReference>
    <dbReference type="PDB" id="6RXZ">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.40 A"/>
        <property type="chains" value="CC=1-523"/>
    </dbReference>
    <dbReference type="PDBsum" id="5OQL"/>
    <dbReference type="PDBsum" id="6RXT"/>
    <dbReference type="PDBsum" id="6RXU"/>
    <dbReference type="PDBsum" id="6RXV"/>
    <dbReference type="PDBsum" id="6RXX"/>
    <dbReference type="PDBsum" id="6RXY"/>
    <dbReference type="PDBsum" id="6RXZ"/>
    <dbReference type="AlphaFoldDB" id="G0S2U4"/>
    <dbReference type="EMDB" id="EMD-10051"/>
    <dbReference type="EMDB" id="EMD-10052"/>
    <dbReference type="EMDB" id="EMD-10053"/>
    <dbReference type="EMDB" id="EMD-10054"/>
    <dbReference type="EMDB" id="EMD-10055"/>
    <dbReference type="EMDB" id="EMD-10056"/>
    <dbReference type="EMDB" id="EMD-3847"/>
    <dbReference type="SMR" id="G0S2U4"/>
    <dbReference type="IntAct" id="G0S2U4">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S2U4"/>
    <dbReference type="GeneID" id="18255889"/>
    <dbReference type="KEGG" id="cthr:CTHT_0018510"/>
    <dbReference type="eggNOG" id="KOG2573">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015495_4_0_1"/>
    <dbReference type="OMA" id="PDNYMFA"/>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000001">
        <property type="entry name" value="Nucleolar protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="11 12 13" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409242" description="Nucleolar protein 56" evidence="7">
        <location>
            <begin position="24"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Nop" evidence="8">
        <location>
            <begin position="302"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="449"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="455"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="467"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="512"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS22327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="5OQL"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="6RXT"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="6RXU"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="6RXV"/>
        </source>
    </evidence>
    <sequence length="523" mass="57735" checksum="1B0EF3845CB22D3E" modified="2011-10-19" version="1">MVVVNFLLFESAVGFSLFEVVHQADTVGLELPEVKDAMKTLDKFGKMVKLRSFNPWTSAAQGLEAINLISEGIMPEYLKSALEMNLPQTSGKKSKVVLGVADKKLAGEITAAFPGVQCEAADTSEVVAALLRGIRTHANKLHKSLQEGDIGRAQLGLGHAYSRAKVKFSVHKNDNHIIQGIATLDALDKSINQGAMRVREWYGWHFPELIRIVSDNITYAKVVLAIGNKSSLTDESVDDLANVLNQDQDKALAIIQAAKVSMGQDISEVDLQMVRDLASNVTSMADYRRILAESLDKKMSEVAPNLQVILGTPVAARLIAHAGSLTNLAKYPASTLQILGAEKALFRALKTKSATPKYGLLYQSSFIGRAGPKVKGRISRYLANKCSIASRIDNFSEKPTRHFGEVLRQQLEQRLEWYAKGTKPMKNSEAMEKAIKAVMADDEETLPVAVDAMDIDSKSPAKEKKDKKEKKEKKEKKEKKKEDKEEKKKDKKRKSLGGEDVEMADADVGENKKKKKRKSEIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0S310</accession>
    <name>G0S310_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase S33 tripeptidyl aminopeptidase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0019240</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692412.1">
        <property type="nucleotide sequence ID" value="XM_006692349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S310"/>
    <dbReference type="STRING" id="759272.G0S310"/>
    <dbReference type="GeneID" id="18255962"/>
    <dbReference type="KEGG" id="cthr:CTHT_0019240"/>
    <dbReference type="eggNOG" id="ENOG502RGY2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013364_5_2_1"/>
    <dbReference type="OMA" id="EVDGPYF"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="3">
        <location>
            <begin position="445"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS22393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="572" mass="63630" checksum="FCF858347BD388A5" modified="2011-10-19" version="1">MKRVTAKQPLSRLPPSPFVNTHIVASSSVAQDDSLGITPSSIPSPVTYPGERISWIPCGTLNNELLECTNLSVPIDHFSERSSDKTFTIPLIRLRSNRTSDTPLPNILLNPGGPGGSGTQFVYRLGAKLRDVLGDGVHLIGFDPRGVNGSIPRASCYKTPELRERLGFVRDKKVVEDSGELWAWSQNFAKACQETMGPHGKYINTPQTAADMNSILDALGQRGLWYWGFSYGTLLGQTYAALFPERTERVVIDGVANQWDWYESRLDKEMMTDTDAVWNGFIEECIKAGKWKCDLAQLASTKEELADMLLREIGKLRDDPVPVYVNAEKYGVLDYWDILYGGIFPALYKPASWSRLASNLAALLKGNATPAFLEYGQKSPFDLEGEAFKVISLNDGLSGPAHWPNTRKALLDELIPFFNQSLFSEDAFDFYFSKQAWTIPRTHTYSPPKRGVSVVQTAHPILILSTTYDPVCPLMSARAASQAYAGSRIVEVKGYGHCSTAVPSRCVANHVREYFYEGKLPKEDVQCEADGSPYFKTMEEQVAAAEALDEEDRRIRFAQLALAEEGIGPWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G0S361</accession>
    <name>G0S361_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0019790</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692463.1">
        <property type="nucleotide sequence ID" value="XM_006692400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S361"/>
    <dbReference type="STRING" id="759272.G0S361"/>
    <dbReference type="GeneID" id="18256017"/>
    <dbReference type="KEGG" id="cthr:CTHT_0019790"/>
    <dbReference type="eggNOG" id="KOG0281">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_103_0_1"/>
    <dbReference type="OMA" id="HSKGIAC"/>
    <dbReference type="OrthoDB" id="19711at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050995">
        <property type="entry name" value="WD-F-box_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604:SF4">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604">
        <property type="entry name" value="WD40 REPEAT PF20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="6">
        <location>
            <begin position="97"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="334"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="374"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="496"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="536"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="210"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="622"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="714"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="852"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="261"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="714"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="760"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="862"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS22444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1033" mass="113431" checksum="4A8337F1FF628337" modified="2011-10-19" version="1">MAAGFTAQPDEGYSEDPLTALSLAASSANSLTKSREGGGLAALAASRGGNDFPQWMLDHLSELPISRKTELVMALLNELPTRVVSQIVNQLSPRLYIDFVSYLPPEVCLKILGYLDPVSLINVAQCCRAWYDLALDRKLWEQLYYLEGWKVLPDEMARAEAEMNGRFAGSDRSGVRRTSSEEDGNSVKKRAISHSPKLDADIDMEMADVESSIPRESSSDSRMSGMSGHSIFGGYQTPGGQGIVSGSKNKMADKGKGKELASCPSSSAPSSISAARLSGPRPRIEKSTLWVWDTGSKRYRLNWKYLYSMRRRLEANWERGKYTNFQFPHPDHPEEGHGECVYTIQYNSQYLVSGSRDRTIKIWDMKTKRCLRTLRKHQGSVLCLQFDSDPEEDIIVSGSSDSDVIIWKFSTGQEVQILKHAHRESVLNVRFDKRVLVTCSKDKTIKVFNRRPLRYGDLGYQPVDPVGRLVKDPANSIPMSPEDYPVIPPWTMIGVLEGHNAAVNAVQVHGREVVSASGDRHIKIWDWPKQTCVRTILAHNKGIACVQYDGRRIVSGSSDNEVKVFDRQSGVEVASLRSHTNLVRTVHAGFGDLPYSVEDDLREARRVDEEYWKAFEQGLLDDSQRSRQGRRQGNAGSRRPQDIRAIGASLPPGGGGGKYGRIVSGSYDASIIVWRRDKEGVWKDQHHFKQEDAALNALRQHWARQAMLQQQQQAYQAAQQQQQQQAGGQRRGAAPPSTTPLAPGGTPSLAVDATLPPTGTIASQSNQPGHNSTPTASFVGHSPLQPIYQIIDNAVQNGPQALLEAIATHPAILQQRTYVNSAIDRLPDPVSRSQLRQAYSGAIIRAQFQHVQQNREELQTQTEGTPAPASTSAAGPGSSQSADIPVAVAASSTHPGSPAMHPYHNLTPAQIAAAEAHQAHSFFPDRRFIPPPPPALAPVNLAGPNPLASHAAIAPAALVSPHVAAAPALQHHPHIAQPPLEMPDTGNPARVFKLQYDARRIICCSQRSVIVGWDFCNGDPELEEASRFFGPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3A8</accession>
    <name>G0S3A8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nuclear distribution protein PAC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Lissencephaly-1 homolog</fullName>
            <shortName evidence="11">LIS-1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">nudF homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PAC1</name>
        <name evidence="11" type="synonym">LIS1</name>
        <name evidence="15" type="ORF">CTHT_0020340</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Self-associates. Interacts with NDL1 and dynein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">Cytoskeleton</location>
            <location evidence="11">Spindle pole</location>
        </subcellularLocation>
        <text evidence="11">Localizes to the plus ends of microtubules at the hyphal tip and the mitotic spindle poles.</text>
    </comment>
    <comment type="domain">
        <text evidence="11">Dimerization mediated by the LisH domain may be required to activate dynein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the WD repeat LIS1/nudF family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692510.1">
        <property type="nucleotide sequence ID" value="XM_006692447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3A8"/>
    <dbReference type="STRING" id="759272.G0S3A8"/>
    <dbReference type="GeneID" id="18256072"/>
    <dbReference type="KEGG" id="cthr:CTHT_0020340"/>
    <dbReference type="eggNOG" id="KOG0295">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_15_1"/>
    <dbReference type="OMA" id="WHVATKE"/>
    <dbReference type="OrthoDB" id="10264588at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051012">
        <property type="term" value="P:microtubule sliding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023052">
        <property type="term" value="P:signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000342">
        <property type="entry name" value="Nuclear distribution protein PAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.960.30:FF:000002">
        <property type="entry name" value="Platelet-activating factor acetylhydrolase ib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03141">
        <property type="entry name" value="lis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017252">
        <property type="entry name" value="Dynein_regulator_LIS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037190">
        <property type="entry name" value="LIS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056795">
        <property type="entry name" value="PAC1-like_LisH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24951">
        <property type="entry name" value="LisH_PAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037647">
        <property type="entry name" value="Dynein_regulator_Lis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109925">
        <property type="entry name" value="Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 11" id="KW-0813">Transport</keyword>
    <keyword evidence="3 12" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="PAC1-like LisH-like dimerisation" evidence="14">
        <location>
            <begin position="7"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="110"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="152"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="197"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="245"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="328"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="351"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF24951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS22491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="462" mass="50735" checksum="CD026ECCA95ACCC2" modified="2011-10-19" version="1">MSQILTSRQAEELHRALIAYLTSNNLPNTAAALRAELGIGEDVFDAATAKKYEGLLEKKWTSVVRLQKKIMELEARNQALQNELDNSTPTSRQNKDPVNWLPKSPARHTLQSHRNPITCVAFHPVFTSLASGSEDQTIKIWDWELGELERTIKGHTKAVLDVDFGGPRGNTLLASCSSDLTIKLWDPSDEYKNIRTLPGHDHSVSAVRFIPSGVAGSSGNLLVSASRDKTLRIWDVSTGYCVKTIRGHAEWVRDVCPSFDGRYVLSTSDDHTGRLWDISLPNPEQKTTLIGHEHVVLCCAIAPPASYPHLASMAGMKKPPPATSSVEFMATGSRDKTIRLWDARGNCIKILVGHDNWVRGLVFHPGGKFLLSVADDYTLRCWDLTQDGRCVKTISDAHGHFVQCIRWAPSIVKEPSVPNGDAQGDANGTPKKNAAPGVIDPSQIRCVIATGSVDLNVRIFAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3H0</accession>
    <name>G0S3H0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative high-affinity glucose transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0021010</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692572.1">
        <property type="nucleotide sequence ID" value="XM_006692509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3H0"/>
    <dbReference type="GeneID" id="18256139"/>
    <dbReference type="KEGG" id="cthr:CTHT_0021010"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="OMA" id="VTCVLVY"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF7">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="11"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS22553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="523" mass="57772" checksum="33E31C616829FF33" modified="2011-10-19" version="1">MQNLAGNIYFIAVIAVIGGALFGFDISSMSAIISTQPYLCQFNQRGFDENGRCLGPTDAVQGGITAAMPGGSWLGALVSGFLSDSYGRKRSIQIGSVIWVIGSILVCTSVNIPMLVLGRIINGFSVGICSAQVPVYISEISPPSKRGRLVGFQQWAITWGILIMYFICYGSAYMKTSAAFRVPWGIQMIPAILLFLGLCILPESPRWLAKHDRWDETTEVLTMIHGKGDPNSPFVHHELLEIREVVEFERANADVSFRELFAPKMINRTIIGVFTQIWSQLTGMNVMMYYITYVFTMAGLAGDSDTAVLLPSGINFVINVIMTVPALLWMDRWGRRPTLLVGAFLMCLWLCVNAGIFAIYSRPPLPGEFTSTAESMAVSGAPAKAIIASTYLFVASFAPTWGPVSWTYPPELYPLRLRGKAVALCTSANWAFNFALAYFVPPAFAQITWKTYVLFATFCAAMFLHVFFMFPETANKPLEEVEKIFDDTQAGAIKYIGVPAWKTKNDRTLIIKQENNEALPKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3M4</accession>
    <name>G0S3M4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0021780</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692647.1">
        <property type="nucleotide sequence ID" value="XM_006692584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3M4"/>
    <dbReference type="GeneID" id="18256216"/>
    <dbReference type="KEGG" id="cthr:CTHT_0021780"/>
    <dbReference type="eggNOG" id="ENOG502SC1V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027731_0_0_1"/>
    <dbReference type="OMA" id="QWCKAII"/>
    <dbReference type="OrthoDB" id="5314201at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="538" mass="59224" checksum="3B42DB0E617A9DAF" modified="2011-10-19" version="1">MDADTLVKVLRKYNVSFDAAVVKAALSDPNSLEASELAHWAAIHLSPDTLLTPDELNQYAALEESGLAEKLAQAPGLAETRVLSEQEIKDAIAALNRSTESITRYNDILKQQRAALDRIVSAAKEGVDAQATLAKDQTEKWKSQRQELILEIQQLSQSLSTRIGELDQQASEAGTHIQELVDTQFQADDKLLASLQKLGLELEIPDTKEHGDVVALRETCARLIKFTVETVKTKLDRIYLETLEELEANNTPITTQVTKNEVNSLQGELESLYSEILPVAQMSVEQQFLEPALKDLAARNRQSLANASQATDYRRPSQVAQLNKAAALLPQEGDALDEKTGINELASILANRRQKAEDVAQNVQETFEDAAMRHLADGKLAIQLVRDSVLAESPYGEVQLVDPEIEGSIGVLTQALAAVEKRLKTVNAALPTLRGKNAKREELVPATKFHKATEMENVKDTLKKGLEKVTKQDKEPLQESGKDELQTMWPTREHHPDLTGGVDTHMGKAAHSGDVAGTPGKEWMRQPTNKPTMGQPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3S4</accession>
    <name>G0S3S4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0030460</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693496.1">
        <property type="nucleotide sequence ID" value="XM_006693433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3S4"/>
    <dbReference type="GeneID" id="18257084"/>
    <dbReference type="KEGG" id="cthr:CTHT_0030460"/>
    <dbReference type="eggNOG" id="ENOG502SUAH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_499647_0_0_1"/>
    <dbReference type="OMA" id="LWNDVED"/>
    <dbReference type="OrthoDB" id="4768051at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS21200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="586" mass="65809" checksum="01B5E7975C2BC09C" modified="2011-10-19" version="1">MSSITQLDDLRSSQEGTVKDQAEEELLSGNKKPFNYEGFPWFGVLWRFGCSVLFSLLVLDVLYVFSGWDHLKTWDRRLFNAITIMLSSLVSLSVGSLLSLLGATLRWPILASRPHTPREVDMILGMSCPSLAAKIIWHHCWRQKKLSRTTLIISIYLLVNIFGRLSVAIFGLTYNLNDTVLTEYPVMVNDFGFKDWIGTHWLGITVDLQKMKNIAVIGLRDVDTFLHPNHPETFNRKNISGHGLDRSVDGRTVTYTYGAREYRGSEAYSSSERIFRSSSTCIARNYWNGTVWEDGKLVGKLPDDPSEVPPPDDPKHIHIMDGLIKAGLLNLAAQLRTCLTDGNGRPGMPQNVFFNYPAENSTYASRVLLSFPAQDDRLYDYGQGSFNAKLYKDQAFYNFTLDLADDCYAPSFISDMTDDWYANLDFNGYEVSAANIMARVPILTLIGAEKILPRVTLLKGATEQHTVVSTLDVKWGRAATTLAALTAGQAIAVVIAWFASRGILLRDHDSFLSIGRIFRTAMTKIEGTPEGGSLASGRQLADAIQKSAYPPGKIRYGTRKKMDWYELDLWDDVDYFFPDPGQAKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3X9</accession>
    <name>G0S3X9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Inner centromere protein ARK-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0039260</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the INCENP family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS22041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006694274.1"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="6123at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Inner_centromere_prot_ARK-bd"/>
    </dbReference>
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        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1229"/>
            <end position="1289"/>
        </location>
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        <location>
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        </location>
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        <location>
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            <begin position="1177"/>
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        <location>
            <begin position="407"/>
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        </location>
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        </location>
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            <begin position="532"/>
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            <begin position="706"/>
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        <location>
            <begin position="726"/>
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    </feature>
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        <location>
            <begin position="892"/>
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        <location>
            <begin position="927"/>
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    </feature>
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        <location>
            <begin position="940"/>
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        <location>
            <begin position="955"/>
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            <begin position="1025"/>
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        <location>
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        <location>
            <begin position="1206"/>
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        <location>
            <begin position="1231"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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            <dbReference type="ARBA" id="ARBA00004186"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00010042"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022490"/>
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            <dbReference type="ARBA" id="ARBA00022829"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03941"/>
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        <source>
            <dbReference type="EMBL" id="EGS22041.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1344" mass="146727" checksum="7561C7C98CCD97AD" modified="2011-10-19" version="1">MRGGPRLQVGSAAWVAEEREAALSIACSEVDEFSYAARNELDWLNEHMADIFSENQMNVAEIFKSPSKFRGKTPRTVRREPSSARVPLASVFSSTPKGAPNPLAMSTISLPRSPAIQVAEDAPSSDSPIPSSPTGRSMSPTKATVVHPMHEVKPRGHGSLADSGYHGSQSQLTQFEREEPLEEEDIEMSDSGEQGETLSDPVFSPENKPTSPSATSVHETYQSPVETRSPQRQQREESAVPTPSSALQQPNSPFASRTRLPIMSPRAQPSPKKTSSPIGQSPGRRSPSPQKSRLASPPKASAKLEPAPQTEEKPEDGADQNISADEEEEDDISEASSPVLRPVMRKSSLNFASLPAREPLTSKKSLGGAAARMSRTSFTRQSYYPPAAASRLTGGGKSLGVGRHEDDDMEGVEKDEDKEEEEVFADSKTYTQRLHEQISMLGKSQAQKSARPSKSLASFLPAAAGQQQQGSAGSMQAGRQASPKPKQQPATTPGPVAANEDDFVRGMGSPRPLPPRPQTSGTTECRDTGDMSPASSLPRSRPTSPSKNVFSPTHRTPNSHSKSQSVPVLPSLEQLRTGNPEDGPKKTIAQNPTLSTAAGDGLVAGSPAPRSPRSFRDNPLKQVKNKLSSFIKSSKGLIGSSGSATLGESKTSSGLVQHTPSVSRAQQQKVEKEREKERAGDESVESYKTADNVAYPDLSRQVEGINPTSAKEQPQSPVQNVRRTRASAERERLEKERAESERQEREKMRVVEKERERVAQMERHITAQQEKEKQEKERREREQDFRTPGPRPKSVAKPAPSTIQTTPHKNAAADEDLDMTEAPATIAPPSVARPTTASSMRIPAAKRPLKPTKEALNRSTAKQAPTVIKVNTSSAAQVSNSVLAATLGETLAPPTNQTTQAQAAQGATAVKGLSGKGSAGSLRDKPSLQSLKNSMASSSQQKQKAADAAAAAAQRKKEQEEREAQKRELQRKREQRERERAAQQEEERRRREEMEQQRRLEEEQRKKEEERKRKAAIEKAKMTKAPPPPVRTQPNGPPDYSATVERERQTQQPARPPSRLGSIAEGGRPLQEEKKYQAAGVDAKRMRMSEEFDENVDMAEGGGGGSSRMIKGAPIRPSTGFKKEIQPPKQHTYSSNAHGHTYSSKDLFKTTVISQHNNQNAGRPAHPLDMAQVAKGPIPFANNNTQAASSHKTPARAPGTNSTVPSSAAKSAARSSPRFPNGELIELPDIATDDDDDYSDADNSGSGAGQMLPSWADSPELRRQLLEQERIDPTTVFGVPQPLNMEEVFNKSKDRWHRFRQRTSSANWSGADRLTEEEMRRDAIARDRMRREGGWTWELGKEMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0S416</accession>
    <name>G0S416_CHATD</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0022210</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_006692625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S416"/>
    <dbReference type="GeneID" id="18256259"/>
    <dbReference type="KEGG" id="cthr:CTHT_0022210"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5307331at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
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            <begin position="537"/>
            <end position="626"/>
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            <begin position="740"/>
            <end position="767"/>
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        <location>
            <begin position="50"/>
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            <begin position="63"/>
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            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
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        <location>
            <begin position="539"/>
            <end position="548"/>
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            <begin position="549"/>
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            <begin position="592"/>
            <end position="604"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="816" mass="90627" checksum="82AE1F67D1699C8F" modified="2011-10-19" version="1">MSKIDGSESFDPFLGSGEVDNLFGEPDPFGLDEIPSLQSPSKLPDVFFKFGEKREHKDDTKASKSSPTETTPTKASKPAAASLTFPTPTPKSTISSNIRDVGFNPPTPDILTPSLDPSLLTLFPLQSQYSRLPLKGQVNATRINTVSQYGNPTLPASKTQLSLLAYGHSQQQPQQTAAVGKGRGCGMPAVSVQASPYGNLDVPMSMPAQTYPLNPYEAQPQPQLRQDTHPHALKQFVTMRQGKRLTYNRRLKGDPKNDPRQIYEPPIGLAPWGPMVGTKQKHHLFEYFRATAELKPMVVWNKAQLITFLRGRGHPNPTRKLTLWIQNTPAQVNDRYPCGTSSSKCRWEGCPARSRTILKGFFRVAFDEYSDQSGIVTDPMHNAGYMHLHCFETLFDLGYLIHHGAARNGFQILPDTREFMFESRNPASLTRDHPEMLDAYNEWVAEQKTRADMLEAQNQGNPVGQMYTGFDLPRVPPHSRRLGCVLTERHLSLEVKGRAQTREQRGGVHIGLHKGDLDLYNKLRRRMIERKRRELDQALPEEEEDQEQDQVQSQSQSQSQGRPGGTKRRRDEDSFESFPQNPNLKRVKQYRPAAAGPSASTSSAYGIPNPTTPLPTSHPNNPAWLYNPQPAILTPNRPPPLLLHQPLQPAPTALSPTTLISLQSPGPLTRHRTRELANSITADVLATTTPYLTRKSAHAAQAMLQDAQALLPAPILEEQVFRAMPEYAAMVLQPCLQQNQNQNQNQNQDQNQNQNQNQNQDQNQDQDLGLGLGLGLGLGLGLGLTLSEVGNGNGNGLAVSAVPRVQQQQQQQQQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0S491</accession>
    <name>G0S491_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ASTRA-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0031140</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the ASTRA complex involved in chromatin remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the ASTRA chromatin remodeling machinery complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat ASA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006693498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S491"/>
    <dbReference type="STRING" id="759272.G0S491"/>
    <dbReference type="GeneID" id="18257152"/>
    <dbReference type="KEGG" id="cthr:CTHT_0031140"/>
    <dbReference type="eggNOG" id="KOG0322">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041940_0_1_1"/>
    <dbReference type="OMA" id="WHKEGVY"/>
    <dbReference type="OrthoDB" id="7668193at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="14"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="494"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="253"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="414"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="330"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS21265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="509" mass="55560" checksum="AFE82DCC5DA065D6" modified="2011-10-19" version="1">MSTESRPAQPKSILRGHKAQVHAAAFVFANERLVTGDADGFVISWDLTIMRPRAVWRAHTNSILGISDWGRDRLITHGRDNKLIVWKLGVEDESRLSTSPPLDPVSRTRPQPEMLHLLEVNTMNFCSFSHCPEVPASGTSSGDILVAVPNTLASEAIDIYHLPSQNRKYTLKLGEKNGMVMALSLLWLGQTLTLVAGYENGLALVAQLDDQGNWLVIYQAKPHTQPILSLDVSPSRDYFITSSADAIIAKHSLSVGSQQPGKQPVPPRAEPTQEIPIPQKPALRNDDSNRPPETKPPTKPAHNDTNKPKSLLSAALANEPRSPPVSQLTPSSISPSFSTPSPLNNNTPIKQINTKHAGQQSLRIRSDGRIFATAGWDSRIRVYSTRTLREVAVLKWHGLGCYAVTFAAVGTDANANSSDGDSAECARKSSVSESGPEEEVIKGDKISKHKEPRSQQDLDECGVDRSNSVAVVPKLVEVTVREKRVHQAMAAHWIAAGSKDGKISLWDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G0S493</accession>
    <name>G0S493_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">uridine/cytidine kinase</fullName>
            <ecNumber evidence="3">2.7.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0039360</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the uridine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.48" evidence="3"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS22051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694347.1">
        <property type="nucleotide sequence ID" value="XM_006694284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S493"/>
    <dbReference type="STRING" id="759272.G0S493"/>
    <dbReference type="GeneID" id="18257974"/>
    <dbReference type="KEGG" id="cthr:CTHT_0039360"/>
    <dbReference type="eggNOG" id="KOG4203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021278_0_2_1"/>
    <dbReference type="OMA" id="EPQLHCE"/>
    <dbReference type="OrthoDB" id="738517at2759"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00637"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004849">
        <property type="term" value="F:uridine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02023">
        <property type="entry name" value="UMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000010">
        <property type="entry name" value="Uridine-cytidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000764">
        <property type="entry name" value="Uridine_kinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00988">
        <property type="entry name" value="URIDINKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="8">
        <location>
            <begin position="50"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="9">
        <location>
            <begin position="264"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS22051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="460" mass="51206" checksum="FE6B0708BF035B2E" modified="2011-10-19" version="1">MSPTSTGTSSDASSLVNGVNNIKLSDRSKTDADILSEKAHYAPPWADVSIIGIAGSSGSGKSTLSQAIVNKLNLPWVVILSIDSFYKNLTPEQSKAAFLNEYDFDSPDALDFDALVERLRDLKAGKRAEIPVYSFEKHARLDRTTSIYSPHVLILEGIFALYDPRVLELLDMKSQVLRDQRDRGRDLEGIIKQWFKFVKPNFEKRKVADIIVPRGVENHVAMAMVTQFIQQKLLEKSKHHRAALTRLEIGAHSEPMSKKVNVVKQSPQIRVMNTIVQNIDTSSEDFIFYFDRLTALLIEQALNQVPFVPATITTPQGCTYAGLRAKGEVSAVLVLRGGAALETGLHRVIPDCKTGRILIQSNIRTGEPELHYLSLPPDIDKHEAVLLLDAQMSSGGSALMAVRVLLDHGVRQDRIVLVTFTAGKMGLHRLTKAFPEISVVVANVVPDLEERWVEKRYFRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>G0S498</accession>
    <name>G0S498_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0039410</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS22056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694352.1">
        <property type="nucleotide sequence ID" value="XM_006694289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S498"/>
    <dbReference type="GeneID" id="18257979"/>
    <dbReference type="KEGG" id="cthr:CTHT_0039410"/>
    <dbReference type="HOGENOM" id="CLU_2542378_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="83" mass="9072" checksum="3B0CF412618B1198" modified="2011-10-19" version="1">MNRTLPISLNLSLQNGPSTHQKQPQRLHELGAQLIKNGVIIVRCPKLDLATPQGITSLNLHISLRPLQAEDAIAFNTRTKAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4H9</accession>
    <name>G0S4H9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0022890</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpF family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692753.1">
        <property type="nucleotide sequence ID" value="XM_006692690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4H9"/>
    <dbReference type="STRING" id="759272.G0S4H9"/>
    <dbReference type="GeneID" id="18256327"/>
    <dbReference type="KEGG" id="cthr:CTHT_0022890"/>
    <dbReference type="eggNOG" id="ENOG502QSUX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026443_0_0_1"/>
    <dbReference type="OMA" id="QIDGMGA"/>
    <dbReference type="OrthoDB" id="10267539at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007400">
        <property type="entry name" value="PrpF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43709">
        <property type="entry name" value="ACONITATE ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43709:SF2">
        <property type="entry name" value="DUF453 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G00360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04303">
        <property type="entry name" value="PrpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS20457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="425" mass="45825" checksum="A397440CA0EF7D68" modified="2011-10-19" version="1">MSRRALSLLPNSVPTSRRIPSTQLPIVFTRFSSSTPSITITNRGRRTLPALFARGGTSNGLIFHAADLPRDRALWRDILAPAMGSPDPKHARQLDGMGSGVSSTSKVCILERSEREDADVDFTFVQVGITDGELDWAGNCGNMSSVVGPAALEMGFVPAERVQVERDERTGERVARVRIWNTNTRKVVVARFTVDEGMPPRFVPEGDYAMAGVPGTGSKVVLSFLKPGGAKTGRVLPTGNAIDRIRLSNGREVEASLVDVSNPGVFVRAGLDLLPFEKLTAAEVEQNEATMNLLEEIRREGARMMGLDPDTPSIPKLVFVDSPIPSQGEYHHHLRCRALSMRQLHKAVPLTLGLCLGAAARIPGTIPFLAAQGVENSSGPGSATVRIAHASGLLEVGTTIDENGELLSADLIRTCRILMKGEVYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4P5</accession>
    <name>G0S4P5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Eukaryotic peptide chain release factor subunit 1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0023060</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic release factor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692770.1">
        <property type="nucleotide sequence ID" value="XM_006692707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4P5"/>
    <dbReference type="STRING" id="759272.G0S4P5"/>
    <dbReference type="GeneID" id="18256344"/>
    <dbReference type="KEGG" id="cthr:CTHT_0023060"/>
    <dbReference type="eggNOG" id="KOG0688">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035759_2_1_1"/>
    <dbReference type="OMA" id="GPGTEKM"/>
    <dbReference type="OrthoDB" id="10254527at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018444">
        <property type="term" value="C:translation release factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000001">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.960.10:FF:000001">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000006">
        <property type="entry name" value="Peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.960.10">
        <property type="entry name" value="eRF1 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024049">
        <property type="entry name" value="eRF1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004403">
        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03676">
        <property type="entry name" value="aRF1_eRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10113">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55481">
        <property type="entry name" value="N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="5">
        <location>
            <begin position="8"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS20474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="434" mass="48863" checksum="76F7DCF4DC2D517C" modified="2011-10-19" version="1">MSDLNGNEAEKNIEIWKVKKLIKRLEAARGNGTSMISLIIPPKDQISRVAKMLAEEYGTASNIKSRVNRQSVLSAITSTQQRLKLYNKVPPNGLVIYCGEILTSEGKERKVNIDFEPFKPINTSLYLCDNKFHTEALAELLESDQKFGFIVMDGNGALFGTLSGNTREVVQKFTVDLPKKHGRGGQSALRFARLREEKRHNYVRKVAELAVQNFITNDKVNVAGIVLAGSADFKNDLNASDMFDPRLQAKVIKVVDVSYGGENGFNQAIELSSETLGNVKFIQEKKLIGKYFEEISQDTGRVCYGIDDTLKALELGAVETLIVFENLEVTRWTLKDSNGTEHILHTTKQQEQDRSKFIDKETGQEMEVVSQESFLEWIAEHYKDFGTTLEFVSDKSTEGNQFVKGFGGIGGILRYKVNFEQLADFDDDDEYYDD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-08-03" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4X6</accession>
    <name>ODP2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial</fullName>
            <ecNumber evidence="5">2.3.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">MRP3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Pyruvate dehydrogenase complex component E2</fullName>
            <shortName evidence="9">PDC-E2</shortName>
            <shortName evidence="9">PDCE2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">CTHT_0032020</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Cell Rep." volume="34" first="108727" last="108727">
            <title>Integrative structure of a 10-megadalton eukaryotic pyruvate dehydrogenase complex from native cell extracts.</title>
            <authorList>
                <person name="Kyrilis F.L."/>
                <person name="Semchonok D.A."/>
                <person name="Skalidis I."/>
                <person name="Tueting C."/>
                <person name="Hamdi F."/>
                <person name="Kastritis P.L."/>
            </authorList>
            <dbReference type="PubMed" id="33567276"/>
            <dbReference type="DOI" id="10.1016/j.celrep.2021.108727"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (6.90 ANGSTROMS)</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="journal article" date="2021" name="Nat. Commun." volume="12" first="6933" last="6933">
            <title>Cryo-EM snapshots of a native lysate provide structural insights into a metabolon-embedded transacetylase reaction.</title>
            <authorList>
                <person name="Tuting C."/>
                <person name="Kyrilis F.L."/>
                <person name="Muller J."/>
                <person name="Sorokina M."/>
                <person name="Skalidis I."/>
                <person name="Hamdi F."/>
                <person name="Sadian Y."/>
                <person name="Kastritis P.L."/>
            </authorList>
            <dbReference type="PubMed" id="34836937"/>
            <dbReference type="DOI" id="10.1038/s41467-021-27287-4"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.84 ANGSTROMS) OF THE PYRUVATE DEHYDROGENASE COMPLEX E2 CORE</scope>
        <scope>FUNCTION</scope>
        <scope>DOMAIN</scope>
    </reference>
    <reference evidence="15 16 17" key="4">
        <citation type="journal article" date="2022" name="Structure" volume="30" first="575" last="589.e6">
            <title>Cryo-EM and artificial intelligence visualize endogenous protein community members.</title>
            <authorList>
                <person name="Skalidis I."/>
                <person name="Kyrilis F.L."/>
                <person name="Tuting C."/>
                <person name="Hamdi F."/>
                <person name="Chojnowski G."/>
                <person name="Kastritis P.L."/>
            </authorList>
            <dbReference type="PubMed" id="35093201"/>
            <dbReference type="DOI" id="10.1016/j.str.2022.01.001"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.84 ANGSTROMS) OF THE PYRUVATE DEHYDROGENASE COMPLEX E2 CORE</scope>
        <scope>FUNCTION</scope>
        <scope>DOMAIN</scope>
    </reference>
    <comment type="function">
        <text evidence="5 6 7 10">The 10-megadalton pyruvate dehydrogenase complex contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) and catalyzes the overall oxidative decarboxylation of pyruvate to form acetyl-CoA and CO(2) (PubMed:33567276, PubMed:34836937, PubMed:35093201). Within the complex, pyruvate and thiamine pyrophosphate (TPP or vitamin B1) are bound by pyruvate dehydrogenase E1 subunits alpha and beta and pyruvate is decarboxylated leading to the 2-carbon hydrohyethyl bound to TPP. The E2 component contains covalently-bound lipoyl cofactors and transfers the hydroxyethyl group from TPP to an oxidized form of covalently bound lipoamide, and the resulting acetyl group is then transferred to free coenzyme A to form acetyl-CoA and reduced dihydrolipoamide-E2. Finally, the flavoprotein dihydrolipoamide dehydrogenase (E3) re-oxidizes the lipoyl group of dihydrolipoamide-E2 to form lipoamide-E2 and NADH. A fourth subunit, E3BP, is responsible for tethering E3 in proximity to the core, forming the entire metabolon.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + acetyl-CoA = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:17017"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="2.3.1.12"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="5">
            <dbReference type="Rhea" id="RHEA:17019"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="2">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <KM evidence="5">68 uM for coenzyme A</KM>
        </kinetics>
    </comment>
    <comment type="subunit">
        <text evidence="5">Eukaryotic pyruvate dehydrogenase (PDH) complexes are organized as a core consisting of the oligomeric dihydrolipoamide acetyl-transferase (E2), around which are arranged multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide dehydrogenase (E3) and protein X (E3BP) bound by non-covalent bonds (PubMed:33567276). The Chaetomium thermophilum PDH complex contains 60 E2 units, 12 E3BP units, about 20 E1 units, and 12 or more E3 units (PubMed:33567276). The units are organized in 1 E2 60-mer, 4 E3BP trimers, about 20 E1 tetramers, and a maximum of 12 E3 dimers (PubMed:33567276). The E3BP trimers are bound inside the icosahedral core with tetrahedral symmetry (PubMed:33567276).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The peripheral subunit binding domain (PBSD), serves as a selective binding site for other domains of the E1 and E3 subunits.</text>
    </comment>
    <comment type="domain">
        <text evidence="11">The C-terminal catalytic domain catalyzes the transfer of acetyl groups and acetyl-CoA synthesis.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The loop element facing inside the core cavity formed by residues Val-405 to Trp-420 is potentially critical for the organization of the PDH complex core scaffold.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.12" evidence="5"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693643.1">
        <property type="nucleotide sequence ID" value="XM_006693580.1"/>
    </dbReference>
    <dbReference type="PDB" id="7BGJ">
        <property type="method" value="EM"/>
        <property type="resolution" value="6.90 A"/>
        <property type="chains" value="A=1-459"/>
    </dbReference>
    <dbReference type="PDB" id="7OTT">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.85 A"/>
        <property type="chains" value="A=1-459"/>
    </dbReference>
    <dbReference type="PDB" id="7Q5Q">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.85 A"/>
        <property type="chains" value="A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X/Y=1-459"/>
    </dbReference>
    <dbReference type="PDB" id="7Q5R">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.85 A"/>
        <property type="chains" value="A/AA/AB/B/BA/BB/C/CA/CB/D/DA/DB/E/EA/EB/F/FA/FB/G/GA/GB/H/HA/HB/I/IA/IB/J/JA/K/KA/L/LA/M/MA/N/NA/O/OA/P/PA/Q/QA/R/RA/S/SA/T/TA/U/UA/V/VA/W/WA/X/XA/Y/YA/Z/ZA=1-459"/>
    </dbReference>
    <dbReference type="PDB" id="7Q5S">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.85 A"/>
        <property type="chains" value="A/B/C/D/E/F/G/H/I/J/K=1-459"/>
    </dbReference>
    <dbReference type="PDBsum" id="7BGJ"/>
    <dbReference type="PDBsum" id="7OTT"/>
    <dbReference type="PDBsum" id="7Q5Q"/>
    <dbReference type="PDBsum" id="7Q5R"/>
    <dbReference type="PDBsum" id="7Q5S"/>
    <dbReference type="AlphaFoldDB" id="G0S4X6"/>
    <dbReference type="EMDB" id="EMD-12181"/>
    <dbReference type="EMDB" id="EMD-12234"/>
    <dbReference type="EMDB" id="EMD-13066"/>
    <dbReference type="EMDB" id="EMD-13845"/>
    <dbReference type="SMR" id="G0S4X6"/>
    <dbReference type="STRING" id="759272.G0S4X6"/>
    <dbReference type="GeneID" id="18257240"/>
    <dbReference type="KEGG" id="cthr:CTHT_0032020"/>
    <dbReference type="eggNOG" id="KOG0557">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_10_2_1"/>
    <dbReference type="OMA" id="TMEFESF"/>
    <dbReference type="OrthoDB" id="537444at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000003">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006257">
        <property type="entry name" value="LAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01349">
        <property type="entry name" value="PDHac_trf_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF90">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0450">Lipoyl</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0670">Pyruvate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000456222" description="Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial">
        <location>
            <begin position="29"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="2">
        <location>
            <begin position="34"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="3">
        <location>
            <begin position="177"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="129"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 14">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 14">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 14">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 14">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 14">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 14">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="site" description="May form a delocalized pi-electron network with Arg-384 of 2 other E2 subunits within the complex, which greatly improves protein stability" evidence="6 14">
        <location>
            <position position="384"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="2">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="33567276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="34836937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="35093201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="8">
        <source>
            <dbReference type="PubMed" id="33567276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="9"/>
    <evidence type="ECO:0000305" key="10">
        <source>
            <dbReference type="PubMed" id="33567276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="11">
        <source>
            <dbReference type="PubMed" id="34836937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="13">
        <source>
            <dbReference type="PDB" id="7BGJ"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="14">
        <source>
            <dbReference type="PDB" id="7OTT"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="15">
        <source>
            <dbReference type="PDB" id="7Q5Q"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="16">
        <source>
            <dbReference type="PDB" id="7Q5R"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="17">
        <source>
            <dbReference type="PDB" id="7Q5S"/>
        </source>
    </evidence>
    <sequence length="459" mass="48721" checksum="6194FC0E279FD6D6" modified="2011-10-19" version="1" precursor="true">MLAQVLRRQALQHVRLARAAAPSLTRWYASYPPHTIVKMPALSPTMTSGNIGAWQKKPGDAITPGEVLVEIETDKAQMDFEFQEEGVLAKILKETGEKDVAVGSPIAVLVEEGTDINAFQNFTLEDAGGDAAAPAAPAKEELAKAETAPTPASTSAPEPEETTSTGKLEPALDREPNVSFAAKKLAHELDVPLKALKGTGPGGKITEEDVKKAASAPAAAAAAPGAAYQDIPISNMRKTIATRLKESVSENPHFFVTSELSVSKLLKLRQALNSSAEGRYKLSVNDFLIKAIAVACKRVPAVNSSWRDGVIRQFDTVDVSVAVATPTGLITPIVKGVEAKGLETISATVKELAKKARDGKLKPEDYQGGTISISNMGMNPAVERFTAIINPPQAAILAVGTTKKVAVPVENEDGTTGVEWDDQIVVTASFDHKVVDGAVGAEWMRELKKVVENPLELLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G0S582</accession>
    <name>G0S582_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ion channel-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0032580</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693697.1">
        <property type="nucleotide sequence ID" value="XM_006693634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S582"/>
    <dbReference type="STRING" id="759272.G0S582"/>
    <dbReference type="GeneID" id="18257296"/>
    <dbReference type="KEGG" id="cthr:CTHT_0032580"/>
    <dbReference type="eggNOG" id="ENOG502QU70">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_521933_0_0_1"/>
    <dbReference type="OMA" id="YARINRT"/>
    <dbReference type="OrthoDB" id="2373987at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056337">
        <property type="entry name" value="LHD_YVC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF4">
        <property type="entry name" value="MEMBRANE CHANNEL PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23190">
        <property type="entry name" value="LHD_TRPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="441"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="509"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="535"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="YVC1 N-terminal linker helical" evidence="3">
        <location>
            <begin position="106"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="4">
        <location>
            <begin position="350"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS21401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="572" mass="65030" checksum="E0793276C4DE102F" modified="2011-10-19" version="1">MLSALLRPFQGSSRSRIDDDHADLADLEQHATSRPSLTEYRNHPHATADFTEADDDDDESNDGNPQSRFPRSRRPGDDDNGFGRSSGLLPLFSDHHLDSIPIYSTTHQIRLLVQSRAETTLTWEQLKSPQVSQFLIKPMQQQIRAQYFSPGTVYCLMANCLQFEKESHLYPGNASTNATRAKVCELLAIKLLREYSTRELIDALCYEFWPLQGCPGSQTPLSFSGGSRSMNVDLRSSTLEIAIRASAKHFLSHPLVMQQIEAIWSGAISFHPSLREVQRQSSHSSGQSRRQSTVRTPLLADQPPKEDFIRLRTLDPTHRSAVLYDPRTASPFKLSRLRVPRYRRLFSTGSLVVLICLYLAVLGQRSSKITGLELLFWFWSAGFMLDEIVGFSEHGVSFYVMSFWNIFDLGSLLLLIVYYCMRIYGVFLLDPHQWNQNAYDVLALNAILLLPRIFSVLDHSKYFSQLLIAFRLLALDLAAVFLLCLVCCSGFFVFFIFSKGRKDPWDHAYSIFQILVGYTPAAWEMWPSYGWLGKALMGLFLIVGHFVILTILVTVLANSFMNIASKTNQEYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5D5</accession>
    <name>G0S5D5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0024420</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692904.1">
        <property type="nucleotide sequence ID" value="XM_006692841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5D5"/>
    <dbReference type="STRING" id="759272.G0S5D5"/>
    <dbReference type="GeneID" id="18256480"/>
    <dbReference type="KEGG" id="cthr:CTHT_0024420"/>
    <dbReference type="eggNOG" id="ENOG502S6UT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047273_2_0_1"/>
    <dbReference type="OMA" id="AFNCHFP"/>
    <dbReference type="OrthoDB" id="20109at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000171">
        <property type="term" value="F:ribonuclease MRP activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034965">
        <property type="term" value="P:intronic box C/D snoRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013241">
        <property type="entry name" value="RNase_P_Pop3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28272">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28272:SF1">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="252" mass="27465" checksum="C4A79E1027639E56" modified="2011-10-19" version="1">MAERKKIVHALDTPYSAVEWPHINQEDQDAILELLCHLLAPLGNYRRTFITPSKGKRKRSAHKKDAPAAPVPPAPELASYVDVGLSQISRNLQAMASSKSQPKPSSEVREEDKDNAMSIDAPAHAVDNSNDGIKPYTIVFVPRGGQSPAFNSHFPQMVALAARSQPAETAVRLVGFSKACEDRLSAVLGIPRVSSIAICEGAPQAKGLVDYVREKVPPVDVAWLKEARRGEFLETKIDAIVTKIGTKKQRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5F5</accession>
    <name>G0S5F5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcription factor MST12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0024620</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Transcription factor that may function downstream of PMK1 to regulate genes involved in infectious hyphae growth. Is not essential for vegetative growth, conidiation or appressorium formation. May be involved in the regulation of the expression of the cell surface sensor MSB2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the STE12 transcription factor family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692924.1">
        <property type="nucleotide sequence ID" value="XM_006692861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5F5"/>
    <dbReference type="STRING" id="759272.G0S5F5"/>
    <dbReference type="GeneID" id="18256500"/>
    <dbReference type="KEGG" id="cthr:CTHT_0024620"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025505_0_0_1"/>
    <dbReference type="OMA" id="EMSRHGT"/>
    <dbReference type="OrthoDB" id="1095242at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990526">
        <property type="term" value="C:Ste12p-Dig1p-Dig2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990527">
        <property type="term" value="C:Tec1p-Ste12p-Dig1p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000243">
        <property type="entry name" value="Probable transcription factor steA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000390">
        <property type="entry name" value="Transcription factor stea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003120">
        <property type="entry name" value="Ste12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052127">
        <property type="entry name" value="STE12_transcription_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427">
        <property type="entry name" value="PROTEIN STE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427:SF1">
        <property type="entry name" value="PROTEIN STE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02200">
        <property type="entry name" value="STE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00424">
        <property type="entry name" value="STE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="550"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="580"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="409"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="596"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="466"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="615"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="631"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="646"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS20628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="707" mass="77339" checksum="13D6F2E0BF17B529" modified="2011-10-19" version="1">MAAPTQKPETFMLSPEAQQALPHDAQVALQQVDNLKYFLLSAPVDWQPDQYIRRFLLPTGEYISCVLWNNLFHISGTDIVRCLSFRFQAFGRPVKNAKKFEEGIFSDLRNLKSGTDASLEEPKSPFLDFLYKNNCIRTQKKQKVFYWYSVPHDRLFLDALERDLKREKAGQEPTTVAVAEPALSFKYDSSQSLYEQLTKAQQANSSAFSLHQLFGTMSSGPIGSMAPPPPMSIPQSIAPPMPQTMPPLSDGMDAMVPYNNMNTMNNMAVAPSIPPATQAVIKREPDYQRVQYNQNGVPIQGHQRHASMPAYGLEYSPAPSFVSSHFDDYSQRGMSFEPMTPPQQALSIPGEPAYIPNEETGLYSAIPNHMDPVGALNGINMLPPSNLAAPAFSRPYTSGLYSAVIEGSPTYKQRRRRSSIPPSLSAANGVMGAPTSVQLRPDLRRSVSASVGPVPEEESENSPPSLTYTNSAASVAHQNDMSRHGTPLPTIEGSPSLEPVPVTQQDYSPIPTSDMGQMGEQRPILQGGPMVRRARSATVMELGPYPQKTHCCPIPTCGRTFKRLEHLKRHVRTHTQERPYVCPYCSKAFSRSDNLAQHKRTHDRGDGAEGSVNSGEEEEQYSGEDPVDDASPTSETSAYVTGSIDSAVNGNSNNSNATGNSNGAPTSSGPSTSTSMPQTTQTFNSLQTLSMPMQISQPQPINAGAMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5F9</accession>
    <name>G0S5F9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Lysophospholipase NTE1</fullName>
            <ecNumber evidence="3 16">3.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Intracellular phospholipase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CTHT_0032820</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 16">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the NTE family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="3 16"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693720.1">
        <property type="nucleotide sequence ID" value="XM_006693657.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S5F9"/>
    <dbReference type="GeneID" id="18257320"/>
    <dbReference type="KEGG" id="cthr:CTHT_0032820"/>
    <dbReference type="eggNOG" id="KOG2968">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_1_1_1"/>
    <dbReference type="OMA" id="SSGYVWR"/>
    <dbReference type="OrthoDB" id="421051at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046470">
        <property type="term" value="P:phosphatidylcholine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000062">
        <property type="entry name" value="Lysophospholipase NTE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000007">
        <property type="entry name" value="Lysophospholipase NTE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001423">
        <property type="entry name" value="LysoPLipase_patatin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056556">
        <property type="entry name" value="NTE1_P-loop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF29">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE SWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24179">
        <property type="entry name" value="NTE_Ploop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01237">
        <property type="entry name" value="UPF0028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 15 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 15 16" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11 15 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="18">
        <location>
            <begin position="707"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="18">
        <location>
            <begin position="885"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="19">
        <location>
            <begin position="1268"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="542"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="756"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="15">
        <location>
            <begin position="1272"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="15">
        <location>
            <begin position="1299"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="15">
        <location>
            <begin position="1419"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="771"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="15">
        <location>
            <position position="1301"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="1419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGS21424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1571" mass="171779" checksum="365E697F0EBB0E0B" modified="2011-10-19" version="1">MDADAVNSALLDSLTSTATQIATTTLRDRHTNALSSAVAAASDVANAHGTWSWLGLMARLALWTLQLISTLVYWALKLATISVPTLLYTLFSTSLTFTMSMPTLLLILAGIVAIVSWVVRYRYLNMYSRLPPEPQRKTPDVDLFPDTHEEGSGKPGLANYFDEFLSAIKIFGYLERPVFHELTRSMQTRKLIAGETFNLEEEKGFCLVVDGLVEIFVKSSSGYRQSRDTVKSPRVGLAGEEVLVVSSDEDDEPAHGQRYQLLTEVRNGAPMSSLFSIMSLFTEDVSMRLPEDDGSEPGSAVQSALLPICPASDYPKLDVMPGSLPGTPQFDDDNDEDPVENLFLSSSASARIPHLSLDGKSTASIGKPQRPAALKRNNTNSAHPDIIARAVVDTTIAIIPASAFRRLIRIYPKATAHIVHVILSRFQRVTLATAFNYLGLTCEVLQIERQMLKYTTRQLPNHLRGDALNRLKEKFKRERGRFGPEEDISKGIALHNANNSRRRRSTNSLRKDAVLLQALSSRHGSVHHVSSASADLISNLQKSRAGGGRPQTATRSESHAHLDLSTSEVVIPSIGQRSSTAMGTAAAFDPFGTQRASHISMIDQRDTLGEDNMFRESILLCVLKALGLGAGYGGPSRDGAKDTDSVHTSSPRLVPLDQRRQRAVLTNHAFGFMDGLEASFDGETESITSAGLPTSSSSPDPRVLAHDMRDEMEIVFFPKGAVLVEQGERNPGLYYVIDGFLDICIAEEEAASSTDVWRATGSRTSLREVGRGSSSTNASTSTSTSTSTSRGGSLCTPRMGAARMRRTGGSVNEGGMKEKGRQPARRSVALVKPGGLAGYIGTISSYRSFIDVVAKTDVYVGFLPLASVEKIVDRYPIVLLTMAKRLTNLLPRLILHIDFALEWLQVNAGQVLFHERDESEAIYIVLNGRLRLVEDRKDGGMNVRAEFGQGESIGELEVLTESSRSGTLHAIRDTEVVKFPRTLFNSLAQEHPNITIKISKIIASRMRALIDDPSGAQGLKDAAGRSSVNKGATTLNLRTVAVLPVSTGVPVVEFGNRLLNALNEVGAPNGAVALNSDAVLNHLGKHAFNKMGKLKLSQYLADLEEKYGLVIYVADTTVNAPWTQTCITQADCILLVGLADGSPEIGEYERFMLGMKSTARKILVLLHQERYSAPGLTRKWLKNRVWINGGHFHVQMTYSPKGVPIHPQAKPSGPTLRERVQILQAEIQKFTGRKDNRHGRSPFYSPDAPFKGDFHRLARRLCGKSVGLVLGGGGARGIAHIGIIRAMQEAGIPIDLVGGTSIGAFIGALYARHADFVPIVNAAKKFAGRMASVWRFALDLTYPSASYTTGHEFNRGIFKAFGNTQIEDFWLEYYCNTTNISKSRAEFHTSGYAWRYVRASMSLAGLLPPLCDEGHMLLDGGYIDNLTVSHMKSLGCDVIFAVDVGALDDDTPQAFGDSLSGFWAFFNRWNPFSTTPNPPTLAEIQARLAYVSSVDALERAKTMPGCIYMRPPIDEYGTLEFGKFHEIYAVGYKYGQDFIGKLKERGVLPLADQSNGKKGLRRTMAPRRASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5G5</accession>
    <name>G0S5G5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0032880</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7 8">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693726.1">
        <property type="nucleotide sequence ID" value="XM_006693663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5G5"/>
    <dbReference type="STRING" id="759272.G0S5G5"/>
    <dbReference type="MEROPS" id="C12.002"/>
    <dbReference type="GeneID" id="18257326"/>
    <dbReference type="KEGG" id="cthr:CTHT_0032880"/>
    <dbReference type="eggNOG" id="KOG1415">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054406_0_2_1"/>
    <dbReference type="OMA" id="PEVWNEI"/>
    <dbReference type="OrthoDB" id="427186at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09616">
        <property type="entry name" value="Peptidase_C12_UCH_L1_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000008">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF17">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="9">
        <location>
            <begin position="17"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="7">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS21430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="250" mass="27332" checksum="552924D6AF2B4CAE" modified="2011-10-19" version="1">MSTAEAPPSPTNPSVPSFIPLEANPDLLTSLLHNLGLSSALAIHDVYSLTDPSLLAFIPRPAYALLLVFPLTKAYEEHRVKEDAERPDYEGKGEGEPVVWFPQTIRNACGLIGLLHAASNGAVRDFVVPGSDLERIIKSAEPLGPRERAKLLETDETLAKAHRDVAVQGDTAAPRAEEDVDLHFVCFVKGKDGGLWEMDGRRKGPIRRGDLEEGEDVLSERALELGPRKFLEREGEDLRFSCVALAGSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5N2</accession>
    <name>G0S5N2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0024870</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692947.1">
        <property type="nucleotide sequence ID" value="XM_006692884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5N2"/>
    <dbReference type="STRING" id="759272.G0S5N2"/>
    <dbReference type="GeneID" id="18256525"/>
    <dbReference type="KEGG" id="cthr:CTHT_0024870"/>
    <dbReference type="eggNOG" id="KOG4288">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055314_1_0_1"/>
    <dbReference type="OMA" id="WERADIF"/>
    <dbReference type="OrthoDB" id="276721at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF16">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="295" mass="31578" checksum="4C1C52F7BAA55396" modified="2011-10-19" version="1">MSATKRIVVFGGNGFLGSRICRAAVARNWDVTSVSRSGAPHWSSVLGTNTPPDWSHKVAWEHADIFQPAQWTSLLSGADYVVHSLGILLEADYKGVISGRESPITGLMKAFSSAKGANCPNPLDRMRAEHTSEPVVDPPKNASQLTYELMNRDSAILLAKEAARHGVSVFGFVSAAGGAPVLPSRYITTKREAEAVVAREFPEMRGVFFRPPFMYDSSRTVTIPLAMMMAAGSAFNGLTGGVLSGFLGAAGTKPLKVDTVADAVVEALEDESVSGLVEVPKLEVLAERAWRKSML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5V8</accession>
    <name>G0S5V8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit G</fullName>
            <shortName evidence="5">eIF3g</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 RNA-binding subunit</fullName>
            <shortName evidence="5">eIF-3 RNA-binding subunit</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Translation initiation factor eIF3 p33 subunit homolog</fullName>
            <shortName evidence="5">eIF3 p33 homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TIF35</name>
        <name evidence="9" type="ORF">CTHT_0033790</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit G family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693816.1">
        <property type="nucleotide sequence ID" value="XM_006693753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5V8"/>
    <dbReference type="DIP" id="DIP-60994N"/>
    <dbReference type="IntAct" id="G0S5V8">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S5V8"/>
    <dbReference type="GeneID" id="18257417"/>
    <dbReference type="KEGG" id="cthr:CTHT_0033790"/>
    <dbReference type="eggNOG" id="KOG0122">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034595_0_0_1"/>
    <dbReference type="OMA" id="ICQGDHF"/>
    <dbReference type="OrthoDB" id="639027at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12933">
        <property type="entry name" value="eIF3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12408">
        <property type="entry name" value="RRM_eIF3G_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000328">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03006">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017334">
        <property type="entry name" value="eIF3_g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024675">
        <property type="entry name" value="eIF3g_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034240">
        <property type="entry name" value="eIF3G_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12353">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037949">
        <property type="entry name" value="Transl_init_eIF-3_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="209"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="166"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS21520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="289" mass="32036" checksum="5600896529F4886F" modified="2011-10-19" version="1">MAARTKHDWADDEDIEETTNDLPPPQKIQNKDGSTTIIEYRYNENGQKVKTTRRIRYITHREVVSPLVAERKTWAKFGASAKDPPGPASDTTSVGENIIFRPSVNWKKEAKDESKDPNAQAMKDKLKDKKVKCRICNGEHFTARCPYKDTMAPIGETAPADVAAGLGDEAPGAAGPGKKGSYIPPALRAGARPEGDRLGGKYGERDDMATLRVTNVSELAEESELREMFERFGRVTRVFLAKDRETGLAKGFAFISFADRADAVRACQKMDGFGFKHLILRVEFAKKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5Y1</accession>
    <name>G0S5Y1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0025330</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692993.1">
        <property type="nucleotide sequence ID" value="XM_006692930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5Y1"/>
    <dbReference type="GeneID" id="18256571"/>
    <dbReference type="KEGG" id="cthr:CTHT_0025330"/>
    <dbReference type="HOGENOM" id="CLU_1586280_0_0_1"/>
    <dbReference type="OMA" id="RWVKNAR"/>
    <dbReference type="OrthoDB" id="3563866at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS20697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="168" mass="18276" checksum="1D1D1A54F89CA8BD" modified="2011-10-19" version="1">MSTSQVELNASAVSLTEARDAQPTGLAPHRSDSVSSSATSITTVSNNQAQQPSTVQNTTNNNTITATNTLPVTNYRPDPPRRSATDIAGPRDPLSRQFPVPAQEPSLDELLARSPPKYSLGRWVKNARTAKPRDDSTAEEAAARRARELEAAKAELRRAKEEMERLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5Z0</accession>
    <name>G0S5Z0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0025420</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
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            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <begin position="1420"/>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
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            <taxon>Sordariomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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    <keyword evidence="4" id="KW-0132">Cell division</keyword>
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    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
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    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="288" mass="31256" checksum="064059823CF66969" modified="2011-10-19" version="1">MAGGQTPPAVQQQQRQDEDVEMRDAPVPVAAPTTSASSQSSAEAPSSDNTANSSPSPQQLTTSNNPTTQCQQAAPADRPQQSAPPPVPGPRAARLQALFAQTVKHTLDKINKDNFASCFPTMAVKAPGTLEFVRRQMVERLGGLWEKEFDSILQNRSVVLRLNELEALVADAGRRRQAHDPNTEPPVPPHTLPAPVVLSSHLRPHFKDQHSRLEKALDETQSTNEKLWAEISAQRVELESLLASLEQAARDVQGAGELLAEVVDKLGEETREGDRVVRQCAAGVLEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6C2</accession>
    <name>G0S6C2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">CTHT_0026240</name>
    </gene>
    <organism evidence="3">
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006693019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6C2"/>
    <dbReference type="STRING" id="759272.G0S6C2"/>
    <dbReference type="GeneID" id="18256662"/>
    <dbReference type="KEGG" id="cthr:CTHT_0026240"/>
    <dbReference type="eggNOG" id="KOG4497">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024072_2_0_1"/>
    <dbReference type="OMA" id="CWHLNGD"/>
    <dbReference type="OrthoDB" id="308690at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990811">
        <property type="term" value="C:MWP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990810">
        <property type="term" value="P:microtubule anchoring at mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052778">
        <property type="entry name" value="Centrosome-WD_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16220">
        <property type="entry name" value="WD REPEAT PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16220:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN WRAP73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="519" mass="56612" checksum="9B8A84EAC51F88DF" modified="2011-10-19" version="1">MLFSPLSKSSPHALPSPDGKYVATVFPGIINVRAVAGLNVVNVIKLGHDFSGPVISFQWSKSSRLLLVADPERIRVVSALDDSFNATVRNHVSAGTKPAVVDFGASDSEICVVAPFGLKFTVFDLKSSRAIEIPNPKVFSALSASTCFSFRPETRHLALLTRSAGKDIVSIHSFPTRELLRSWSPDTVDAQGLAWSPDGRWLAVWDSASQGHRIVFYTPDGHAFRTWAGPTNPQPEDQDFALGPGVKSLQFSADSRYVAIGDFSRSVSVLSVSSVTETLRLRHPKTLAPTETLQVWQEQIGISHAGPAIHTFLRATQPISPAPSSRDSPELLSGCSLIAFDHSSTLVATRLDDCPTALWIWDVQVAELRAVLLFHGNVASISWHPHVSETLLIRCDGDQYDGSAFVWDPLSEGPRFVDFAQRLPAAKTCGKQRVLWLGAPDTDPANSCPSIFFSDTQVFLLAFLGDSDQGPPPWGADGPPSPTFAPPDRRRVESPLELVPAEDESDDYNEVEDTFIHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6M4</accession>
    <name>G0S6M4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0026730</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693131.1">
        <property type="nucleotide sequence ID" value="XM_006693068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6M4"/>
    <dbReference type="GeneID" id="18256711"/>
    <dbReference type="KEGG" id="cthr:CTHT_0026730"/>
    <dbReference type="eggNOG" id="ENOG502QYDH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007183_1_0_1"/>
    <dbReference type="OMA" id="NTWHEAP"/>
    <dbReference type="OrthoDB" id="19394at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027842">
        <property type="entry name" value="HAM1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045967">
        <property type="entry name" value="HAM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138:SF1">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14613">
        <property type="entry name" value="HAM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19343">
        <property type="entry name" value="HAM1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAM1-like N-terminal" evidence="3">
        <location>
            <begin position="10"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="HAM1-like C-terminal" evidence="2">
        <location>
            <begin position="654"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="828"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="853"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="870"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS20835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="880" mass="100005" checksum="3B8599C238B13AF7" modified="2011-10-19" version="1">MPSLMASKRRTRVNKPVDVKERQADVNRKLQLYGIIHAFKHGKVPSNDQIDVALNSFLESKPLSNPSKKLSEDGQTLVADVREVVRQAKYLLLSKNNGNLLQDFIWQTQQFDPTEVAVPEAPLDKERSRRHMNQALEGLRTLGTLIISNGQFRKLLKDASILLRDIAGDAAVNAATRVRPKTEDLAQLDEPAEDNTWYDVPGISKDGIKNKLHQFYNDKTKEKAKVATLESLPTTTSNVSLAPVSPMAPVLTEVKDSQESRGSRVEGAAGSSVVSRLEDAVEQQGNADTEQYAKAKMKEKKSEYRERMKKYLASKMPQERREQIVWRLKKMIIECQQHPDYQRAIQTLLDLSKEYGNHARRMAKGGSESLMDARAALYQAERDLKLLIERFANGTSTDDLWASIKTIYEDAEQDPELRYWFKAMNDYIRRCLQEQGYILDEDSNTEWDQLYEEGNYLLRDKYRGHTDRIVDEVKFLLSQFDEDPQIKAFAASLSKLFNDLGNDEKGKPTFKPRLVKDLTDVILPSIFEKVAYIPIPRIEYSDPHVDVVIENLVLESDNFMPNVLEISSENYLRYGRKTVTSRSRHSFEVKVSGIQMDLRDVSYYVKRKQGFPSMTDTGVANMLLAGDGLSFRIKLVSADEKDAQCFFKIEEVEVDVEHLRIELIKSNHKLLFNIFKPLMLKLLKPGVQRALEKTIKDQATRLDKLLFEIKQEADRALEQAREDPRHVPNFYKRYMTAAQKRILQSKKKRRKILTDKKVNYAITQKDSIFPDVHLPGGISAKATEYKELALRGDSWESPIFSVGNAAKSRDIPPAPKVVRKPHAISKTAALSLRGGSPASPNQGVGTPQEDWLSASTASQNILSPSARAMSQREKFEGKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6N5</accession>
    <name>G0S6N5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0035010</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693933.1">
        <property type="nucleotide sequence ID" value="XM_006693870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6N5"/>
    <dbReference type="STRING" id="759272.G0S6N5"/>
    <dbReference type="GeneID" id="18257539"/>
    <dbReference type="KEGG" id="cthr:CTHT_0035010"/>
    <dbReference type="eggNOG" id="ENOG502QW07">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022149_0_0_1"/>
    <dbReference type="OMA" id="SANWQFE"/>
    <dbReference type="OrthoDB" id="5598844at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013933">
        <property type="entry name" value="CRC_Rsc7/Swp82"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597:SF3">
        <property type="entry name" value="CHROMATIN STRUCTURE-REMODELING COMPLEX SUBUNIT RSC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08624">
        <property type="entry name" value="CRC_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS21637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="526" mass="59481" checksum="62288FB600566BE7" modified="2011-10-19" version="1">MPSRRSGRAAAKRAQQALESTPKTFEGIDDEDEPMPDAAEQEDAEAKDDADEDGDKDDGSVVEEEAVEEDEEESAKSPTPPPEPVVRRRRLGRPPKNRPPDWDQLPIEPPNPDATPRRRGRGGWRGRGGRKGQQQQPQQQAVEVDGVFYNIVDDELDLPEDPEGEEKVDKLGNLKGGREYRCRTFTVLGRGERLYMLSTEPARCVGFRDSYLFFTKHKRLHKIIVNDEEKRDMIERDIIPHSYKGRSIGIVTARSVFREFGAQIIVGGRRIIDDYEVAKARADGVVEGELADPNDIFDPDKPYNKNQYVAWHGASSVYHSGGPSVPQQNVKADTKKRRVAVNDVNWQLEHAREASHFNSVLSAVRRQNLNGVYDIHTNTMFYPRTMQPTHARIVQVNDSEVSPDAHKSKVFPPLKPSISRNFLVLDTHLETPPAGISPAAYDVPFRTSRADYENWLATDFTAPFKGLMAVSDEIRDLLPPECRAAFDRAREQEENWFAKWGDEKDCTSRREPIIDKAIVPYSMTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6T7</accession>
    <name>G0S6T7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0026830</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693141.1">
        <property type="nucleotide sequence ID" value="XM_006693078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6T7"/>
    <dbReference type="GeneID" id="18256721"/>
    <dbReference type="KEGG" id="cthr:CTHT_0026830"/>
    <dbReference type="eggNOG" id="ENOG502SN0C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_29_1_1"/>
    <dbReference type="OMA" id="IDANGPP"/>
    <dbReference type="OrthoDB" id="5283415at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="39"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="251"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="336"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="388"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS20845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="451" mass="49703" checksum="033812DCFBC550D9" modified="2011-10-19" version="1">MDAFTILAHPALSGSSVLHAFALFVNFFFPALALIVVGLRVAGRVVAGQFAIDDWLVGIAMLLSLAQTVVSFFFIKTNFIGIPPEKVPPHDPTQGLIWLYAVQILYQPILSLVKSSALIFLSRLFGQKEWVRRTLVWFNAVNIAHMVGTLFAVVLQCLPIPFNWDPTTTNGRVTITSIIRLLLLIQGLFALSIFPRAMMDGNIGFVTSVIETNLALITASAPALRPIFRSRANGGWFATARSMAVSRKTVSDESDEVEKGLRKIRSRKSIDANGPPPVVGSGVGGKFGRGGRRGGRSMRNNPLFSRRNKMEWKPSGFRGDNKIRGVRNRHIIRVRTDLVTPLQGPAPPSPRTSEEPLTRTRSNTNGGVTIRVSDIQREIDGIINAHKPSCWPSSAAAFSPSSGPSSKRGPPCQAKYQREHEGQQNCRAGATLQRKHLPRRPRQREHQAQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6Z8</accession>
    <name>G0S6Z8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0035620</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693992.1">
        <property type="nucleotide sequence ID" value="XM_006693929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6Z8"/>
    <dbReference type="STRING" id="759272.G0S6Z8"/>
    <dbReference type="GeneID" id="18257600"/>
    <dbReference type="KEGG" id="cthr:CTHT_0035620"/>
    <dbReference type="eggNOG" id="KOG1620">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042569_3_0_1"/>
    <dbReference type="OMA" id="FRICGMK"/>
    <dbReference type="OrthoDB" id="338650at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000824">
        <property type="term" value="F:inositol-1,4,5,6-tetrakisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008440">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF103">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE MULTIKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="277"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS21696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="392" mass="43184" checksum="86B4D71BABBFB624" modified="2011-10-19" version="1">MAGIKELPSHADLKPFNHAAAGHEGTLSDPDGMLFIKPCTQQEIDFYEKAREHPDFAELMPEYLGTLSLNPTGLADDLEKQVTNEITQQAAAGPSTTSGGSTWQPNKNRKLVTDKSVVLENTTYGYKKPNILDAKLGIRLWADDAPLEKRQRFDEISRTTTSGSHGFRIAGMRVYKGSDDPADLDDEGFKVYDKNFGRFEVNGENLVDAFRKFIFNPRAGIDEDLGKAVAEAFLVDLKKVEKVLSANETRMYSASLLFTFEGDGEALRSAIEKANEEHDALEKVESNKDVDTDGSEKTDGAVASSDAESSVKGKLPDVSGPIEGDLKVIEMTGSKLPDDDDDEDVEMTDVPKIYSLKLIDFAHAEWVPGQGPDENNLFGIRNLIKIFEELVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G0S738</accession>
    <name>G0S738_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase II holoenzyme cyclin-like subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0036030</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694032.1">
        <property type="nucleotide sequence ID" value="XM_006693969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S738"/>
    <dbReference type="STRING" id="759272.G0S738"/>
    <dbReference type="GeneID" id="18257641"/>
    <dbReference type="KEGG" id="cthr:CTHT_0036030"/>
    <dbReference type="eggNOG" id="KOG0834">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038278_0_0_1"/>
    <dbReference type="OMA" id="GITWIDN"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0195">Cyclin</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="66"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="321"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="387"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS21736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="441" mass="50834" checksum="8306FAEA68451D98" modified="2011-10-19" version="1">MAPQPDQSPAPAVNGTTAEEHPPIGPPSGLSVIRTQYSSEQSLRQMLKNIGYDEAREDTLRLKGVQLIDTVRQSLQLPVRTFDTAAIYYHKFRMRFPSHEYAYEDVALASLFVACKAEDTIKKSKEILCAAHNLRQPHDHKTPDDKVFEPQTRVIIGLERYILETIGFDFRVQYPQKLLIKMVRKMFPREDASQQEEGKQFLRVAYDMAIDIYKTFAPIKQTSFTLVLAILELTSLLLDTDAEKMRAFKEAASWHSEKAAVFETLLDLLDLYTQFPKSTKIGLRFELKKLMDVKIEINNLMTREKYQRYQGWCDRCAPDPHDTRSLTPSSITSPATNPSLSGTTSVKRKATSTEGTMRFVFDADEARKEKALVDRYFIDEYEEHEIEVEEPIKEPEPRHNSRNTHPPHRGMQGDHGWPGYHRSSRHGLHNDRHRSRRGHGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7D9</accession>
    <name>G0S7D9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA damage-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0036510</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DDB1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694079.1">
        <property type="nucleotide sequence ID" value="XM_006694016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7D9"/>
    <dbReference type="STRING" id="759272.G0S7D9"/>
    <dbReference type="GeneID" id="18257689"/>
    <dbReference type="KEGG" id="cthr:CTHT_0036510"/>
    <dbReference type="eggNOG" id="KOG1897">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002893_1_1_1"/>
    <dbReference type="OMA" id="HQDFLMR"/>
    <dbReference type="OrthoDB" id="433457at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="6">
        <location>
            <begin position="1"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="7">
        <location>
            <begin position="380"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="5">
        <location>
            <begin position="733"/>
            <end position="1069"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS21783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1100" mass="122503" checksum="5DAE48E8DF44967A" modified="2011-10-19" version="1">MLQKLRPRDSKTDLLFVATDRFDYFTLLWNPQTFRLETVNSYKDPGERYMRDSQSQDRCLVDPSGRFMIMHLWEGVLNVWRMGHRKNNAMVLEWMEQVRLSELFIKASTFLYTETGHPKVAFLYQTRADATDAKLATYRLTSDDRDTVASQFNPEKDRELDMEVRDSTASMLIPVRKVEEEVKRHNVRHVELAKAHLGGLIVVGETRLLYIDEVTKAKVESVLKEPSIFVAWAEYNVTHYFLADDYGHLHLLRIKTNGVVVTGMEVSRIGETSRASTLVYLGDNYLFVGSHYGNSQLLRLDLENQNPKQRLQLIESFQNIGPILDFAIMDMGNRGDSGQPGNEYSSGQARIVTCSGVHKDGTLRSVRSGVGLEDIGILADLELCRGLFSLRSHGSLKTNILVMSFLTETRVFKFDHQGDIEELSSFCGMTLDQQTLLAVDLPSGQILHVTPAAATLLDTESGVAITSWTPEEGRCIINASANAEWLLLSVDGVGLVSLSLSNDLRILKEKNLNQSDQIACLHVPPQSSGIGVVGFWTSGTVSIIDLHTLEPIHGESLRTSKDDTSIPQDLALVQLLPPEVSGPLLLIATQDGNVVSFNISSDYSFSGKRRVVLGVTQAKFHLLPQENNLYSVLATTEHPSLIYGSEGRIVYSAVTAEEAAYVCPFDSEAFPDCVALATDSQIKLARLDRERKTYVRSLPLNEMVRRIAYSPKEKVFGLGCIKRELVKGEEIVQSSFKLVDEVLFDRVGKSIELGSPSYTELVECVTRAEFIDSYGNPAERFLVGTSYLPDPDYSPAPSHGNPEARGRILVLGIDSDRNPYQILSYQLKGACRCLAVMDDGKVVVGLTKAVTVCEYKETSSTTAQLTKLASYRPSTYPVEIAIHGRTIAVADLMKSISLVDYIPAEEGGQAKLVERARHYQSAWSTAVGYVQNGLWLEADAQGNLQVLRQNVDGITEDDRKRMELTAEINLGEMVNRIRSITVETSPEALIIPRAFLGTVEGGIYMFGTIAPHALDLLLRFQEKVADVIKAVGDSDNANFRSYRAFKNAERVGHGPFRFLDGELLERFLDVDEAIQEVICSGLGPTVEDMRNIVEELRRMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0S885</accession>
    <name>G0S885_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0037930</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694215.1">
        <property type="nucleotide sequence ID" value="XM_006694152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S885"/>
    <dbReference type="GeneID" id="18257831"/>
    <dbReference type="KEGG" id="cthr:CTHT_0037930"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_27_3_1"/>
    <dbReference type="OMA" id="SYWAFIF"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF23">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="523"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="85"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="550"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="569"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS21919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="587" mass="62558" checksum="118DEB86A34BB2D8" modified="2011-10-19" version="1">MASADEKSTLSLMQQADNGASMARTGQSASSVSPEGTDTTGSTATAEAPTPTQDNADAEKAGAKPANTFGERPACFRNTVQEGAFVFQATMATATSSFSQGASAIITASIGHSLDMTQGQITWITASTALTAGAFQLGLGQLADLLGRKATFIVGMGSFSAFSLLVAFAQNPFWMDVVCGILGISSAMVVPPAIGIMGAAYATPSKRKNLAFSAFSAGNPLGFVFGSIVSGIATMIFNWRAAYIFIAILWVIFTLLAIWTIPKVEAFPPDQPFRERLKTFMKTFDFVGTALTIFGTGLLTAGVTIGPDDEWKGKWVIALIVIGVALLVIFAWWETVYPTPPMPPHIWKDRNFTFIILSCLPGYMSFISSQFWLSFFMQEVQHLKPLTVAVHLLPQAIAGLIYNGIAGSVLHRINNTLLLVIGSCAYVAAAVLLSVMKLNSPYWAFIFPSLILAVVGADFQFNVANMYVMQSLPPHQQALAGGIFNTIFRLSSAIALGLSTAVFSSTKSSAAAMADIMVPYEKAFQVSIGLSAGSFLFLPFVRLGTQGHAPKSVDADTSDGIQTPSVVLEGERSRGEKQESVSEREKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8H6</accession>
    <name>G0S8H6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0029910</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693446.1">
        <property type="nucleotide sequence ID" value="XM_006693383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8H6"/>
    <dbReference type="STRING" id="759272.G0S8H6"/>
    <dbReference type="GeneID" id="18257029"/>
    <dbReference type="KEGG" id="cthr:CTHT_0029910"/>
    <dbReference type="eggNOG" id="ENOG502S8B6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027006_0_0_1"/>
    <dbReference type="OMA" id="DITFMTI"/>
    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043:SF17">
        <property type="entry name" value="PROTEIN SIMILAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="17"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="167"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="232"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="529"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="581"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="237"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="533"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="585"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="596"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="608"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS21150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="696" mass="77946" checksum="8B1FDF824EA3D5B6" modified="2011-10-19" version="1">MDPRDITFMTIHNLTPDANILFASDSIQDILGYTPDEVKGKSAFDYFHPDEVPFARSVHSRGILLDKAAVLHYARIQSKTGQWVPCECCFTVVHNVLVASTSMYFESPKSERRALAAPRIRRIFSSSPRDPRYRMLEHLSPKFKMPPMEREPRAALILNRFTRNLTIMYATDAVTQILGLTPAELVERPFYECIQPNCVEEAEQCLERAKENESIAYLRFWYKDPRIELNNPRVREEEEEDEEEEEEEEEEEESDDEEDNEIEMTDEETKRPDSDSDMDLDDPSPRRRRNSVENLDPLSRPANSSAVLRRRRPVAPPPQTFELEAVVSCTSDGLVVVLRRARPPIPDPEPPVPPPPPFNYENGLFAAPWGVQPYEPYFPPETLYTFRPPLLPQYMPLRECVKAAGGPPLEQLMQSIRDVAVFAWALTGINGTLAATYGNGRNRLGVGPKPDGLPMWEPPPPPHPPPPAAGHGLAAAVGVGGSVEGEKLGKEREYESFGAGVGAAATGYNAEPPVTQYRTRHASLDEGMYAADSPSRGWPSSSSSSAGTAPQAYGLKADERVGGFERPSLRPAFSYDALQEHARYQQQQQQQQQQQQRRRRRRRRRQQRGLDSDRNREPRGYGPLASSSDGLRAWGETTTPSVPAPIPAPVPAAGRSCMPASGPGYGYGGYEPHRYRYGVPAREEGYGMGRRGDGWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-12-14" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8J2</accession>
    <name>G0S8J2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0038280</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694248.1">
        <property type="nucleotide sequence ID" value="XM_006694185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8J2"/>
    <dbReference type="GeneID" id="18257866"/>
    <dbReference type="KEGG" id="cthr:CTHT_0038280"/>
    <dbReference type="HOGENOM" id="CLU_2346503_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS21952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="97" mass="10689" checksum="E2B867A0D5F02D76" modified="2011-10-19" version="1">MTISPACPELMPAEALIQMLSNCLSSNNAAALARTKRRRAAIGREQPDTIIWEIGQKTIPIFNKVIVDQSREGFVGCCRPILTDGSSSHFSEPEWES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8J3</accession>
    <name>G0S8J3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SMODS and SLOG-associating 2TM effector domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0038290</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694249.1">
        <property type="nucleotide sequence ID" value="XM_006694186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8J3"/>
    <dbReference type="GeneID" id="18257867"/>
    <dbReference type="KEGG" id="cthr:CTHT_0038290"/>
    <dbReference type="eggNOG" id="ENOG502RJMA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080475_2_0_1"/>
    <dbReference type="OMA" id="ECFDLYQ"/>
    <dbReference type="OrthoDB" id="5398270at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041622">
        <property type="entry name" value="SLATT_fungi"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033635">
        <property type="entry name" value="SLATT_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38793">
        <property type="entry name" value="SLATT_FUNGAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38793:SF1">
        <property type="entry name" value="SMODS AND SLOG-ASSOCIATING 2TM EFFECTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18142">
        <property type="entry name" value="SLATT_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="SMODS and SLOG-associating 2TM effector" evidence="3">
        <location>
            <begin position="120"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS21953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="271" mass="29078" checksum="2D50CC7AE153EA31" modified="2011-10-19" version="1">MATNKDEIIDLAISPITLDPRPATPGPGIFVRNSPAAGTAGPPAGDNSKEKPSPDADSPAPEPQHSSGHHRFLTPTEWARVAHGLGAICPNDNGETHQVVHPTSCLWPPKGLPDGLYRDIVTQRSKYSIGYTILNALHWIFLTLQIAVGASLTALGSSGLASPSFDDENPRDAPITILAAINTVVAGLLALMHNSGLPERYRKDMNEFDKIKNHVREILDTGIVGMDQTVDDVLDECFTLFQTAKDTVTLNKPESYNTPNPEPGKQGNPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8M7</accession>
    <name>G0S8M7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Folic acid synthesis protein FOL1</fullName>
            <ecNumber evidence="10">2.5.1.15</ecNumber>
            <ecNumber evidence="12">2.7.6.3</ecNumber>
            <ecNumber evidence="11">4.1.2.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">Folic acid synthesis protein fol1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">CTHT_0038640</name>
    </gene>
    <organism evidence="27">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Catalyzes three sequential steps of tetrahydrofolate biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19949"/>
            <dbReference type="ChEBI" id="CHEBI:17836"/>
            <dbReference type="ChEBI" id="CHEBI:17839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="EC" id="2.5.1.15"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11412"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde</text>
            <dbReference type="Rhea" id="RHEA:10540"/>
            <dbReference type="ChEBI" id="CHEBI:17001"/>
            <dbReference type="ChEBI" id="CHEBI:17071"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="EC" id="4.1.2.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the DHPS family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the DHNA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="22">In the central section; belongs to the HPPK family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.15" evidence="10"/>
    <dbReference type="EC" id="2.7.6.3" evidence="12"/>
    <dbReference type="EC" id="4.1.2.25" evidence="11"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694283.1">
        <property type="nucleotide sequence ID" value="XM_006694220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8M7"/>
    <dbReference type="STRING" id="759272.G0S8M7"/>
    <dbReference type="GeneID" id="18257902"/>
    <dbReference type="KEGG" id="cthr:CTHT_0038640"/>
    <dbReference type="eggNOG" id="KOG2544">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008023_2_1_1"/>
    <dbReference type="OMA" id="NIPHKLM"/>
    <dbReference type="OrthoDB" id="615426at2759"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrial envelope"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:folic acid biosynthetic process"/>
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        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dihydropteroate synthase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK"/>
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        <property type="entry name" value="Dihydropteroate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DHP_synth-like"/>
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        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Hppk"/>
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        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="FOLATE SYNTHESIS PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941:SF1">
        <property type="entry name" value="FOLIC ACID SYNTHESIS PROTEIN FOL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK"/>
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    </dbReference>
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        <property type="entry name" value="Dihydropteroate synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DHPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="19" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="16" id="KW-0418">Kinase</keyword>
    <keyword evidence="18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="25">
        <location>
            <begin position="301"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00009640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00009951"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00012458"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013043"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013253"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
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            <dbReference type="ARBA" id="ARBA00022909"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
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            <dbReference type="ARBA" id="ARBA00023268"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00058009"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00061548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00067568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00068111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="EGS21987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="578" mass="63569" checksum="0C1DDB647062078A" modified="2011-10-19" version="1">MKRVALVATQPLRPSQALLSRARCVCRCAPVPRLARTDRRPLSTTARRPDESNSNKFQPFRRYTFPPDFCEKNPVVILPPQKPKMNGPELPERRTAYIALGSNMGDRIGWIEKACREMDARGIKVKRTSGLWETEPMYVLDQDRFVNGACEVETTLEPLELLDALQDIERALGRQKVIDKGPRNIDLDILLYENIKFNHERLKIPHVGIPEREFVLRPLAEYVPFPSTPPPAPFPPPSLPFNFPIDTPRLIPDKPIDPDRPWRLIRDYLDALPPSKSPITTMTPLSAHHSPIQALNPARKTHVMAILNVTPDSFSDGGTHSPSDPDSLVQTITSFLDAGATMIDIGGQSTAPGAPEVSLEEELSRVLPAIRLIRTHPSLSSRQVLISVDTYRAAVAEAAISAGADIVNDVSGGSLDPAMLPTVARLGATICLMHMRGTPATMNDLAVYPPEKGGLIGGIATELLARVKAAEEAGIRRWRIVLDPGLGFAKRGPQNVEVLRRLEELRAWPGLQGLPWLVGSSRKSFIGQVTGVPTPRERIWGTAATVAAAVQGGADVVRVHDVREMVQVVAMADAIWRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8V2</accession>
    <name>G0S8V2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">2-oxoisovalerate dehydrogenase subunit alpha</fullName>
            <ecNumber evidence="9">1.2.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0043530</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the BCKDHA family.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="9"/>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694748.1">
        <property type="nucleotide sequence ID" value="XM_006694685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8V2"/>
    <dbReference type="STRING" id="759272.G0S8V2"/>
    <dbReference type="GeneID" id="18258391"/>
    <dbReference type="KEGG" id="cthr:CTHT_0043530"/>
    <dbReference type="eggNOG" id="KOG1182">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029393_1_2_1"/>
    <dbReference type="OMA" id="GMFRGVN"/>
    <dbReference type="OrthoDB" id="3845at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000015">
        <property type="entry name" value="2-oxoisovalerate dehydrogenase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050771">
        <property type="entry name" value="Alpha-ketoacid_DH_E1_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="12">
        <location>
            <begin position="112"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="484"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS19863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="508" mass="56803" checksum="51065D7268A3C8B1" modified="2011-10-19" version="1">MKSIRAPLLLRRQGAASALQHALRRQSHPTSILTASSTRQLRRSSSLSQRLDAKHVMFPGAVKSEFSSTMRFEHPSTYPALPTYRVVDQHGVVVDQSFTPDLSDEEVIKLYRDMLTISIMDVIMFDAQRQGRLSFYMVSAGEEAVSVGTASALAKEDVVFCQYREQGVFQQRGFTLAEFMNQLFANHKDYGKGRNMPVHYGSKQLNIHTISSPLATQLPQAAGAAYALKIQRMQDPSIPPRVVAAYFGEGAASEGDFHAALNIAATRSCPVIFICRNNGYAISTPTLEQYRGDGIASRGLGYGIDTIRVDGNDFWAVREVTKKARDLALQDGGKPVLIEAMTYRVSHHSTSDDSFAYRARVEVEDWKRRDNPIARLRKWMEAKGIWDENKEKEARESIRRDVLKAFAEAEREKKPPLRAMFEDVYEELTPDLKKQMGELKIPNMSNNDRVVIAVLIVLSITVILAVVGIKYVRQVARSRITARQVDHGEANEAGESENHGQAQAQAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9B2</accession>
    <name>G0S9B2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glucanase</fullName>
            <ecNumber evidence="11">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0045200</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="11">Belongs to the glycosyl hydrolase family 6.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="11"/>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694908.1">
        <property type="nucleotide sequence ID" value="XM_006694845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9B2"/>
    <dbReference type="SMR" id="G0S9B2"/>
    <dbReference type="STRING" id="759272.G0S9B2"/>
    <dbReference type="GeneID" id="18258558"/>
    <dbReference type="KEGG" id="cthr:CTHT_0045200"/>
    <dbReference type="eggNOG" id="ENOG502QWHE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015488_0_0_1"/>
    <dbReference type="OMA" id="WVDTIAN"/>
    <dbReference type="OrthoDB" id="64893at2759"/>
    <dbReference type="BRENDA" id="3.2.1.91">
        <property type="organism ID" value="1279"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.40:FF:000001">
        <property type="entry name" value="Glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.40">
        <property type="entry name" value="1, 4-beta cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016288">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036434">
        <property type="entry name" value="Beta_cellobiohydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001524">
        <property type="entry name" value="Glyco_hydro_6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876:SF2">
        <property type="entry name" value="GLUCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01341">
        <property type="entry name" value="Glyco_hydro_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001100">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00733">
        <property type="entry name" value="GLHYDRLASE6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51989">
        <property type="entry name" value="Glycosyl hydrolases family 6, cellulases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00655">
        <property type="entry name" value="GLYCOSYL_HYDROL_F6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00656">
        <property type="entry name" value="GLYCOSYL_HYDROL_F6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 11" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="5 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005130813" description="Glucanase" evidence="11">
        <location>
            <begin position="18"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="349"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="358"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7 10">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001100-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001100-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS20023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="397" mass="43555" checksum="D460316A2F60D09C" modified="2011-10-19" version="1">MKLTTSTLLSLATAALAAPNPTHTTPLKPRQASHGCPSAVTLDAKTNVFRQYTLHANNFYRSEVEAAAAQISDPTLAAKALKVADVGSFLWIDTIANIKRFEDNLVDVPCDHIFGAVVYNLPGRDCAAKASNGELRTGEINRYKYDYIDKIAEIIKKHSNVAFALVIEPDSLPNLVTNSDVQKCRDAAREYREGVAYALRTLNLPNVVMYIDAGHGGWLGWDSNLRPGAEELASVYRSAGSPSQVRGIATNVAGWNAWDLTPGEFSRASDAQWNQCQNEKTYVEVFGRYLRDAGMPNHAIVDTGRNGVQGLRKEWGNWCNINGAGFGQRFTTNTGSELCDAFVWVKPGGESDGTSDPSAERYDSFCGKEESFKPSPEAGQWNQAYFEMLLRNANPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9C0</accession>
    <name>G0S9C0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ring finger-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0045280</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694916.1">
        <property type="nucleotide sequence ID" value="XM_006694853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9C0"/>
    <dbReference type="GeneID" id="18258566"/>
    <dbReference type="KEGG" id="cthr:CTHT_0045280"/>
    <dbReference type="eggNOG" id="ENOG502SBV2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062278_0_0_1"/>
    <dbReference type="OMA" id="CHFHWDC"/>
    <dbReference type="OrthoDB" id="46529at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS20031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="272" mass="29350" checksum="137FBF4B5911BD99" modified="2011-10-19" version="1">MTTLTCQTCHDPLIIPIEPDSDVEEQPACSSSSSSPQTVPDDLLLPCGCHFHWQCFLDLASTIYSSLRCPSCNAYLPSESAGSSSKPTNPQILTTYTNEGGVQPSLDLYPTLQEEAYLAANPSSRPARAFQSFASEGDVQGMVSVLRSLIEPDSDSEDDSNTPKLTPAEVLTYRDPLNNDKTALHLAIENRQEEAVWALLWLGSGAPTELFPPAVPAAAVGLGLPRRLEQGPIPVEEDVRFVRDGEGRTAGDLCLEIGEGWEKLVQGGLFMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAF7</accession>
    <name>G0SAF7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Annexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0042110</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="domain">
        <text evidence="4">A pair of annexin repeats may form one binding site for calcium and phospholipid.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the annexin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694614.1">
        <property type="nucleotide sequence ID" value="XM_006694551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAF7"/>
    <dbReference type="GeneID" id="18258249"/>
    <dbReference type="KEGG" id="cthr:CTHT_0042110"/>
    <dbReference type="eggNOG" id="KOG0819">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025300_4_3_1"/>
    <dbReference type="OMA" id="DYNSRFM"/>
    <dbReference type="OrthoDB" id="37886at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018252">
        <property type="entry name" value="Annexin_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF102">
        <property type="entry name" value="ANNEXIN B11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00223">
        <property type="entry name" value="ANNEXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0041">Annexin</keyword>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0111">Calcium/phospholipid-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="26"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="63"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="147"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS19729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="533" mass="59562" checksum="EEB0915CDD3671FB" modified="2011-10-19" version="1">MSQPPYYQSYPGTTAPPPGSPLPASYAQQPLAPAPTAAAPYGYQQSPQSPYYGYQPTPGQYQAPPPQPGQYQPPPSPQPGQYQPPPSPQLGQYPPQPAPAPYGQPAPPPVPGQQTLQPAPAPYGQPVPSPGLYPQMPGAYPSPSPQPQAQTYGQPQYGQQPPYGQPLQPQYGQQPVYGQPVPVPGQPQLQAYPGQPQYQPYPPPCTRGYESTPLPPLNPLPEHIITSDIRNLRTAMKGMGCDETTLISILTSPRYRDPWAMHTLVTQYNDRTVRNLDEDIKKETGGLLEDGLRALVRGPLRQDVYQFEKSCDGAGTDEEGVMDVLLNRSNADLRAICAEYKRRHGKELSDRLKKEVNEETMRLFSMLLSGTTKAEENAPVIPADIDAKVTEIQRSTEGMFFANAISVAQIFTSCNQAQLRALQDHYRAKYQRDLLDVVKKEFRGDFQDAVIRMLVHARDRAQCDAMRLQKSLWGNKTSEKRLFVWRVCQLWWDRERLTAAKQAYVRTYRRTLEEDVKVLLNGNAERFVLALLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAI4</accession>
    <name>G0SAI4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0042400</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694641.1">
        <property type="nucleotide sequence ID" value="XM_006694578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAI4"/>
    <dbReference type="GeneID" id="18258278"/>
    <dbReference type="KEGG" id="cthr:CTHT_0042400"/>
    <dbReference type="eggNOG" id="ENOG502S8ZQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1481816_0_0_1"/>
    <dbReference type="OrthoDB" id="5418749at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42030">
        <property type="entry name" value="DRBM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42030:SF1">
        <property type="entry name" value="DRBM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="18856" checksum="ACFCA75075BD2725" modified="2011-10-19" version="1">MAYSRWQDKLGEVCRECKVDPPFFQIVSDRRGGRTAWSSTVTAFGKVHSARFWYDGKYVDNAREDAAEVALNWLASEAGGYAPGATMGAAVPINALPITPGMGVTAAGGSLGGSPVWGAATAAAGQYGAPSPRPIAPPMHRYNQSGTYSPTPSAAGSPPASMSPASMSPTTPSSTGRGSYFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAQ0</accession>
    <name>G0SAQ0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0043070</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694707.1">
        <property type="nucleotide sequence ID" value="XM_006694644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAQ0"/>
    <dbReference type="GeneID" id="18258345"/>
    <dbReference type="KEGG" id="cthr:CTHT_0043070"/>
    <dbReference type="eggNOG" id="ENOG502QTVA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017511_2_0_1"/>
    <dbReference type="OMA" id="CFIGWAG"/>
    <dbReference type="OrthoDB" id="2016285at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010487">
        <property type="term" value="F:thermospermine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000288">
        <property type="entry name" value="Spermine/spermidine synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037959">
        <property type="entry name" value="MFS_SpdSyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43317">
        <property type="entry name" value="THERMOSPERMINE SYNTHASE ACAULIS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43317:SF1">
        <property type="entry name" value="THERMOSPERMINE SYNTHASE ACAULIS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS19822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="612" mass="66672" checksum="0ECDDA2852A04697" modified="2011-10-19" version="1">MLPPQVSKPSPSGSSPSPQSKVEIINPDTTKDQKTFEHELQSLAAKAKSDTPLNWLRAQALIYARSATLLALLALASTLSQLALSPVYGSLPSARYHRHVLLSGMFVGWAGNLGLEAGLEKLGMKRMQCLLPLVIAYMPVVQHLLGGYSTLLGAAWGPVVTEVITFLPVVVLSVACCATWLDQADLGFVPLPGWVVDALPGIGAYAFFRGMEWLLGPALESVIGSGRFGGVVSSRVGMELVLSGVYAAVAPSSLLLWALPALLHTAFWNTHLPTSSALARVNGELAKEGFVVLDRRESVTGYVSVIDNLNEGYRVMRCDHSLLGGEWTKFIGVGPLKGNQVAEPVYAVFAMLEAVRLVEVERPVPDNEAKALVIGLGIGTTPATLVAHGINTTVVEIDPVVHDFAEKYFQLPPNHTAVIEDAVSYTSRLAADENGQRFDYIVHDVFTGGAEPIALFTLEFLQNLHKLLKPGGVIAINYAGDLALPPPRIVVRTIKTVFPSCRIFREHERNATEFAETGRDFTNMIMFCTKQADRAISFRPPTERDMLNSPSRQMFLYPRHEVGEGDLGEAEQGEGILRRNETEAIAKWHGMSAAGHWSIMRVVLPARVWELW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAZ9</accession>
    <name>G0SAZ9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">N-terminal acetyltransferase C complex catalytic subunit mak3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0048380</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. MAK3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695201.1">
        <property type="nucleotide sequence ID" value="XM_006695138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAZ9"/>
    <dbReference type="STRING" id="759272.G0SAZ9"/>
    <dbReference type="GeneID" id="18258876"/>
    <dbReference type="KEGG" id="cthr:CTHT_0048380"/>
    <dbReference type="eggNOG" id="KOG3139">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_0_3_1"/>
    <dbReference type="OMA" id="LCIFARH"/>
    <dbReference type="OrthoDB" id="249099at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044542">
        <property type="entry name" value="NAA30-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="17"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS19379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="196" mass="22093" checksum="9990C5F0C95D9124" modified="2011-10-19" version="1">MATTERKPLPSDLKYIQYEHSLEERYLPAIRALISKDLSEPYSIYVYRYFLYQWGHLCFMALDPSTDALIGVIICKLEMHQSHSPATLRGYIAMLAVEAAYRGQGVATALVKMAIDAMARRRADEIVLETEETNIPAMRLYERLGFLRSKKLHRYYLNGNSAYRLVLPLKSGVYSRGVGGFGPDGSDLYGAIGEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>G0SB08</accession>
    <name>G0SB08_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 13">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="2 13">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0048470</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="13">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="2 13"/>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695210.1">
        <property type="nucleotide sequence ID" value="XM_006695147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SB08"/>
    <dbReference type="STRING" id="759272.G0SB08"/>
    <dbReference type="GeneID" id="18258885"/>
    <dbReference type="KEGG" id="cthr:CTHT_0048470"/>
    <dbReference type="eggNOG" id="KOG0660">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="OMA" id="SFFDFDY"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075018">
        <property type="term" value="P:positive regulation of appressorium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07849">
        <property type="entry name" value="STKc_ERK1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000040">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000073">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="21"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS19388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="353" mass="41040" checksum="7E34C32317B29B20" modified="2011-10-19" version="1">MATQVSRGGTRKISFNVSEQYDILDVVGEGAYGVVCSAIHKPSGQKVAIKKITPFDHSMFCLRTLREMKLLRYFNHENIISILDIQKPRSYETFNEVYLIQELMETDMHRVIRTQELSDDHCQYFIYQTLRALKAMHSANVLHRDLKPSNLLLNANCDLKVCDFGLARSAASQEDNSGFMTEYVATRWYRAPEIMLTFKEYTKAIDIWSVGCILAEMLSGKPLFPGKDYHHQLTLILDVLGTPTMEDYYGIKSRRAREYIRSLPFKKKVPFRQLFPNTSELALDLLEKLLAFNPVKRITVEEALKHPYLEPYHDPDDEPTAPPIPEEFFDFDKHKDTLTKEQLKRLIYNEIMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBB6</accession>
    <name>G0SBB6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0049640</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695318.1">
        <property type="nucleotide sequence ID" value="XM_006695255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBB6"/>
    <dbReference type="STRING" id="759272.G0SBB6"/>
    <dbReference type="GeneID" id="18259002"/>
    <dbReference type="KEGG" id="cthr:CTHT_0049640"/>
    <dbReference type="HOGENOM" id="CLU_138679_1_0_1"/>
    <dbReference type="OrthoDB" id="2107880at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061671">
        <property type="term" value="C:Cbp3p-Cbp6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037653">
        <property type="entry name" value="Cbp6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28250">
        <property type="entry name" value="CYTOCHROME B PRE-MRNA-PROCESSING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28250:SF1">
        <property type="entry name" value="CYTOCHROME B PRE-MRNA-PROCESSING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20180">
        <property type="entry name" value="UQCC2_CBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS19496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="108" mass="12563" checksum="E6409A60E50795BF" modified="2011-10-19" version="1">MSAARTLPVKHFQSLLTRWPVDSLRPDCQLQNVLAKRLGTGKLAPTVPKTFKSQENADLVQFRPRPDLLEPKSNPTYYKDVLKEIEEAPHRTWWQRIAKRITGMIRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBG8</accession>
    <name>G0SBG8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Oxidoreductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0050220</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="12 13 14" key="2">
        <citation type="journal article" date="2022" name="Sci. Adv." volume="8" first="eadc9952" last="eadc9952">
            <title>Conformational changes in mitochondrial complex I of the thermophilic eukaryote &lt;i&gt;Chaetomium thermophilum&lt;/i&gt;.</title>
            <authorList>
                <person name="Laube E."/>
                <person name="Meier-Credo J."/>
                <person name="Langer J.D."/>
                <person name="Kuhlbrandt W."/>
            </authorList>
            <dbReference type="PubMed" id="36427319"/>
            <dbReference type="DOI" id="10.1126/sciadv.adc9952"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.44 ANGSTROMS) OF 661-883 IN COMPLEX WITH [4FE-4S] CLUSTER</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695370.1">
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        <location>
            <begin position="775"/>
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        <location>
            <begin position="814"/>
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        <location>
            <begin position="81"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="576"/>
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            <begin position="90"/>
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            <begin position="187"/>
            <end position="199"/>
        </location>
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        </location>
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            <begin position="586"/>
            <end position="600"/>
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        <location>
            <position position="784"/>
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        <ligand>
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    <sequence length="883" mass="96714" checksum="9227A68812DA02AA" modified="2011-10-19" version="1">MAAKPQPEARSLSDINLLAANPPQYPHHPDLRESLTLYISRVPGKQDIILSTFRPQKKSVTAEDVTNALYYIHLNTPEDEMLVSQQRPTSVKSPRSSFESSRSVIPRKPLPESARVSGVAARSGGGDASSVARTSVPPLSRPPQPNAQSQSTPSPIGAPVGSGELSVGGYQENPMFRRRPSGARYDAPALSPSPSILSTSPPPSLSPINRYSDVRTSTDTRPVTPNYLESQGITSPNRPNTTGLSPATSSPSKLNNHQFPSPSRTGQRPSSVSFSLTIIRRDPTSNTQCNVGKVWSFQTNVPTPENATPNLDPQNMGELQAPKIDIRIETSGYAKYRDMPTPASVEAFRAAGVDLLRQHPLQVAADGSNEVTIPALKPKLLLKPVGREEGFSRQVLMSYGPSWRSSFMKAFHRRDGSVGVPIGSPLEDSSGPKSFHIRHGSASTIMSIDSIDGSASAPLITEPGPGLKPKGYVFVSPWGGRCEFRTSSNGRSLKCRHILDTAANSKLDPRELAHHIRDAQAMGRSRGDELSSALLGAKLVSELRFNLPSKSHQRTSSRDIGAIKTNQLSEQFSKLLHQKPRAHADTDDEWDDDDDYDDNGDSAGLDLSLGREHAGGGSRGRRAKLVELSLIVRENDNDNPSARALPSDYTIVASSRIPSTMLPTPAALLVTRQLPLARVPSTLVRTLPIQALIARRTYATPAGPPPKNFRLPPPKNWDEESESTIDKVGKYFLMTEMLRGMYVLLEQFFRPPYTIYYPFEKGPISPRFRGEHALRRYPSGEERCIACKLCEAVCPAQAITIEAEERADGSRRTTRYDIDMTKCIYCGFCQESCPVDAIVESPNAEYATETREELLYNKEKLLANGDKWEPELAAAIRADAPYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBH0</accession>
    <name>G0SBH0_CHATD</name>
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        <submittedName>
            <fullName evidence="2">Zinc finger domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">CTHT_0050240</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EGS19550.1"/>
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    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
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            <begin position="555"/>
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        </location>
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        <location>
            <begin position="667"/>
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        </location>
    </feature>
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        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
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        <location>
            <begin position="574"/>
            <end position="583"/>
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    </feature>
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        <location>
            <begin position="588"/>
            <end position="598"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="686" mass="72470" checksum="DCD38FC2C68D55E2" modified="2011-10-19" version="1">MATSQLGEHRHMRNGSLNIPSQQSRHGGVVAPMPGPGHRFDGPRSPPSVGADGDAAIAACRQPFLRLSHTAVIADFWACACPYHRRQIPLMFPANSIAREPAKREMPVPSATISTRHLKLSASTLQRCVVDEFEAVLRRGLVMSTWIKASGNCKFGPKCANVHVLPDGRRVNYSKNGVTIGPPPVPLGVRVSPLAYHQPSNSALTNSFLRADAIPTYHPPPPPPPAATYGLQDDRFGSQLGPQPGADNNVPTIDTTFTSNPPSVYGSPRDEDTGRLSMGLSPAVKGLSVMDAPLPASFDSNGISHAARYGPWPASVPSKFGLESPSPSLSAAREGRTSETLKMLHTSAFGSSDHLPPSAIGIGDVNGFGGSSPALGSATLGSGLGSDDFFGKRSLHSSSLRYAKPRLMSSSVPKIDRDWEPEFMFEEDYVPGSLANEVLTPAEKARRGSSSMRIFDTPDPVSTGESLPISMTKFGSPLGQSPSRWTSLFQKQKEEEMELGGSRSLKHIAAFGHVGSPLRNSSLATAFTAEEDDARDAGTDSVSALTRQLRETHLAPAGSGISSPLPNPIGPRTIKSNGATTPNVGVIGEKEHGLERHITSPTVTPSVTTKFSSQIDEEDSVFRMEEEDEAQLRAKKSSTSTNPSAAGATSPLSSGWSYASVVANSSSGALTQSASAATPEATSETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBJ7</accession>
    <name>G0SBJ7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative exchanger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0053820</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006695655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBJ7"/>
    <dbReference type="STRING" id="759272.G0SBJ7"/>
    <dbReference type="GeneID" id="18259420"/>
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    <dbReference type="eggNOG" id="KOG2399">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:intracellular calcium ion homeostasis"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="NCX, central ion-binding region"/>
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    </dbReference>
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        <property type="entry name" value="CaCA_antiporter"/>
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        <property type="entry name" value="NaCa_Exmemb"/>
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    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266:SF0">
        <property type="entry name" value="MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266">
        <property type="entry name" value="NA+/CA2+ K+ INDEPENDENT EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
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        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="8">
        <location>
            <begin position="104"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS18773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="435" mass="47740" checksum="984DF6F6B925E75A" modified="2011-10-19" version="1">MTSLRRHNRDRPVAAAMILVSVITAIALFQHVPVTASRGAGKVELRSRAFQEQAVGCRAVHRATDQCAFVRTKCEDDEAGLLPYLTFYYCTLGGARPVAFVLLATWLGLLFTTIGIAASDFFSVNLSTIATVLGLSESLAGVTFLAFGNGSPDVFSTFAAMGSNSGSMAVGELVGAAGFITAVVAGSMALVREFKVSRRTFVRDIVFFIVAISFTVVFLADGELHLWECFVMIGYYIFYVIVVVGWHWWTARRRRQRILAAATQSHLYGVSGYGSAELEPYRDEFEENDNEAAPMAAGRLPNISEPADITVLELGPRIEVDGVRTSPESPDVDDEERGLHVAAEMASSMRVNRPRWARNNSTITPIRPSLVGVLEFRRVAWPLKSEVPITRNGLNHSRSPLFVGEFLMDRTYRQPCPPGGIVTAWNPCKFSRADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBS9</accession>
    <name>G0SBS9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0054660</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006695737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBS9"/>
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    <dbReference type="GeneID" id="18259504"/>
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    <dbReference type="eggNOG" id="KOG3106">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OMA" id="CILIWAI"/>
    <dbReference type="OrthoDB" id="7694678at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="245"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
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            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="351"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS18855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="379" mass="42680" checksum="0574535EB0DB944B" modified="2011-10-19" version="1">MAFGFFRIAADLSHVTSKCILLFSIHRNRSSEGVSLLTQVFYALVFVTRYTDLFTETHAWNYCLKVFYLLSSFYTIAVMRFVYPRTREREVAWKLSAMILLGSLVLSPFFMLIFEPKYLWSFQDFLWVFSQILESVCVLPQLLLLRQTTVPTVITSFYIVFLGAYRALYLVNWFLRELDPNDRRPNPISVIFGIVQTALYADFAWVYWSRQRVKLRNGGIVDADDLRRGWLLRRIFGAKPLAREIDGEGGDEESAPALGGSRGGFNHQPLNGGRPSRAKWGSRGISISADEGVFDSRVDDDDDDDVEQGVTSAAADPDAKMRDPDELARALDDDDEDDNNALPGASKGQVSTESSNSISPSSAKGKQSRSEEENAWSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBW6</accession>
    <name>G0SBW6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3752 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0055040</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695837.1">
        <property type="nucleotide sequence ID" value="XM_006695774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBW6"/>
    <dbReference type="GeneID" id="18259542"/>
    <dbReference type="KEGG" id="cthr:CTHT_0055040"/>
    <dbReference type="eggNOG" id="ENOG502RXM1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067132_0_0_1"/>
    <dbReference type="OMA" id="NKAADFG"/>
    <dbReference type="OrthoDB" id="73491at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022226">
        <property type="entry name" value="DUF3752"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046331">
        <property type="entry name" value="GPAM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370:SF1">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12572">
        <property type="entry name" value="DUF3752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3752" evidence="2">
        <location>
            <begin position="224"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS18892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="406" mass="43301" checksum="420F5CBFA7C758B1" modified="2011-10-19" version="1">MVSIGPTLPPHLQKRKRTPDEDSELPSPPPKASRRDHDDEIPLYDDSDDDYGPCAPGSSARNGSDTNQSRPGPTVGPSLPPAVTVGPSSVPAAEKQPIGPTPPQPIASINEDEIPLNDGSDSDSNEPSPAPPPLKPTVGPAAPPPKRVFGPAPPPADLNSLPTTDPNYDNNASSDSDDDDEWGPKLPTGSPDSRPITVGPAFPSTNTQSSQSSAPKRDDWMLAPPTSSDHRAPDPTKLRGRRFLSGPRATAAAASRASGGVSSVWTETPEEKARRLANAVLGREDPTAVTAASQSRPDRKESKPVDESRIREYVEQTRGRSLVEEYQARRAASAGKSGSDKESSSNGRKEKWGGGPEVEEEDDPSKRAFDWEKDMKIGGRLSGAQRRDIMKKAANLGGRFQRGNYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCD6</accession>
    <name>G0SCD6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Restriction of telomere capping protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0056840</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in a process influencing telomere capping.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RTC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696007.1">
        <property type="nucleotide sequence ID" value="XM_006695944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCD6"/>
    <dbReference type="GeneID" id="18259722"/>
    <dbReference type="KEGG" id="cthr:CTHT_0056840"/>
    <dbReference type="eggNOG" id="ENOG502SEU0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030573_1_0_1"/>
    <dbReference type="OMA" id="HEDQDSI"/>
    <dbReference type="OrthoDB" id="128308at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039024">
        <property type="entry name" value="RTC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028094">
        <property type="entry name" value="RTC4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391:SF1">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14474">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01312">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Restriction of telomere capping protein 4 C-terminal" evidence="9">
        <location>
            <begin position="330"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="452"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="459"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="469"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS19062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="483" mass="53554" checksum="7EE8BAC48FCDF768" modified="2011-10-19" version="1">MKQVSDDAPPLSSSDLSDSDDGLPRRGDIQPTLFSSNKSRKRPSLSQDEDDEWGSKRMGAASKRPRTAAKSSVPKEPKSGPEIKRKTTETITLSSSPIAPESPKESKEKDKKQDSKDMQDDDLIFSFMKKPKATYGSRNKFTKPATTTCPSTEKTPERKKKPKSTGTGFIRPPSLPPLSDSTPDTGFKRPPDLPGDTPEKPITGFRMPPPLPGMSDDEAGTANANKPSSTDKTTSIDVLSLSGSDSPMTDLSDLFAIPKCPLCQKEVSAELLEAFKKEHSLTTVAAMRNFCEQHNKKSARETWNNKGYPDINWSKLDERIAKYYPVLRDILELRKPSYYREKFSDSIKDGGNKTLLRSDVNLTPGYYGIRGLQHMSENLISKFSGLLRERAVLDKLVSARGTTRFLQSVLVPELAMRLVMEDMNVGEEEARKVLEESSWVGDLLNDEIADVVNVDSDDDKANSEREQQDFSDDGDVDSGSQDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCG8</accession>
    <name>G0SCG8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0057180</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Endoplasmic reticulum membrane</location>
            <topology evidence="2 10">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the OST1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696039.1">
        <property type="nucleotide sequence ID" value="XM_006695976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCG8"/>
    <dbReference type="STRING" id="759272.G0SCG8"/>
    <dbReference type="GeneID" id="18259756"/>
    <dbReference type="KEGG" id="cthr:CTHT_0057180"/>
    <dbReference type="eggNOG" id="KOG2291">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031381_1_0_1"/>
    <dbReference type="OMA" id="RYEYARE"/>
    <dbReference type="OrthoDB" id="310030at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007676">
        <property type="entry name" value="Ribophorin_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049">
        <property type="entry name" value="RIBOPHORIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04597">
        <property type="entry name" value="Ribophorin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005130820" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1" evidence="10">
        <location>
            <begin position="23"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS19094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="487" mass="54679" checksum="05C62271DC300C5D" modified="2011-10-19" version="1">MKATAILSAVASLLSLATAATAESPFKPPQVWKNANLVHIISLEKNYVKENINVLVENVDNRPHDEYYVPFTADQLSRLGGVEVKDRKDPTVGPFGAELVEVKESDTQYLRIRLPEPVAPGAQQTLGISYYLLKAYTPLPASIRQEEQQYLRYTFSAYCPSAYMTAKQKTEVKFPSGNIADFTKLPGAGDVKEFPQRQGSKLVYGPFDSQPAYASQPVTVRFEFNKPVTHVSRLERDIEVSHWGGNVAFEERYTLHHRGANLSALFNRVKWQQAQFYAPTQTWALKELKFPLRAGSVDAYYTDVIGNVSTSRFRSNKREAVLEIRPRYPVFGGWKYPFTIGWNSDAKNFLRRTGTTSYVLNVPFLEGPRTVEGVEYGEVQVRVILPEGAENVRFLTPIPLTSLYSAEISLHRTYLDTIGRTALVLRARNLVDDFRDRELIVAYDVPLTAVLRKPAVVFASGVAVFVAAWLVGRVELKFDAPSGKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G0SD73</accession>
    <name>G0SD73_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Putative ATP-binding cassette (ABC) transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0059190</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696238.1">
        <property type="nucleotide sequence ID" value="XM_006696175.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0SD73"/>
    <dbReference type="GeneID" id="18259957"/>
    <dbReference type="KEGG" id="cthr:CTHT_0059190"/>
    <dbReference type="eggNOG" id="KOG0054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_27_6_1"/>
    <dbReference type="OMA" id="NTNIFRD"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000092">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000825">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000610">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="526"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1017"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1101"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1204"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1229"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="267"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="609"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="944"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1292"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="355"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="879"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1409"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="882"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1409"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1426"/>
            <end position="1446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS19293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1570" mass="173727" checksum="87A673433714C386" modified="2011-10-19" version="1">MPLDSMLTTFATGVGLIGLCSAPALSSTVKRFTRRQERKQDVYEDEDGSATPESMAAYSAKIPKALVLTSAGVGLAVSTTLLVISSGTHGEPVLDGLGIGAWALLTLQAVSIASSRNSIQAYNLGLYTFLSSMILAGILIVRGTMIGESLLQSSRSIFTLRVVEVFASVALAFSGLALPRRPDVFYKGELVDRMYTNSAFSRFTYSWPTSILDLAAKKKDLDLKDLTRPDHLTRSDSVSAAWKKKNFKYPLWISLILAHKRALTIQLLLTLVTSVLNFAPQWVILQLLRLLERHEPGTSHGLDAWIWVGLLCLAIIVRSWVESYTIWLSYADLHIPVRAQLSALIFEKSMRRKDSKGAEKKKKDKFQEGGEDGSSEQQEEARAPVDEEEQLKKSKQSIVNLIGVDGKRIADFACYQYLFPDSLFKLIVSLAFLVSLLGWKALLAGFSAMIAIMPVNIYFSKRYANAQDRLMKLRDEKMEVVTEALQGIRQIKFSALEGEWEKKIGEVRERELSAVWSVFKNDTMLLACWITSPILLAALSLAVYAYLNSSLSPSVAFVSLGVFKALEMTLSIVPELTTDALDAWVSIKRIEQYLNSPEIIKISQDGEEVAFINASIAWPADEEIDEKDRFVLRNINVTFPKGELSVISGKTGTGKSLMLSAILGEADILEGTMQVPRAPPLLERHDDKANKSNWIIPNAIAYVAQIPWIENASIKDNILFGLPYDEERYHKTLEVCALTKDLEMLADGENTEIGANGINLSGGQKWRVTLARAIYSRAGILVLDDIFSAVDAHVGRHIFERCLNGELAEGRTRILVTHHVALCESKTKYLVELGNGGVLHAGTVAELRAKGILQEINSHEKAALGSDKADVDDLATAVNSEDCSEGEGEQDGEGTNGDGLKKVPPKPTAPARKFVEEESREQGAIRKHIYVTYLKDSGGWLFWVLAVVFFTVVQCFTLGRSWWLRIWTGDQETQEVHMHRAHSAAGVNGFTYTEGAHQTTLHTASWPTFEVQRTLPFYLGVYIALAIISSVLSTLKYFYIYTGSIRASRKLFAKLNFTILRTPIRWLDTVPLGRILNRYTADFNIIDSQLANSLSFGAGSFLNLISVLVAGLIVSPYILVLGSALLLICLHYALRYLDAARPVKRLESTAKSPVFEQFGSALTGVATIRSFDKAQVYVERMYRKIDDYSTATWHLWLFNRWMGWRLSLVGSFFSSSLAALILMNPNIDSALAGFALAFAIDFTGAVMWTIRMYANVELNMNAAERIIEYTKLATENLGGMRPPAAWPTEGRIEVDNLVVSYAPDLPPVLKGLTFSVNRNERIGVVGRTGAGKSSLTLALFRFLEAQSGSIHIDGLDISKIRLHDLRSRLAIIPQDPVLFSGTIRSNLDPFNRHTDEELYDCLERVHLIPPGSRSGSSTPTIREEQPSGSTGTTSPKLTLSTPVTESGLNLSQGQRQLLCLARAIATRPKIMVLDEATSAVDMATDALIQRSIRSEFRDATLLVIAHRLSTIADFDRVLVLDAGRVVEFGTPRELWEKEGGVFRGMCEESGERERLKGFIFGEGEASSSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDD3</accession>
    <name>G0SDD3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbon-sulfur lyase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0051380</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695479.1">
        <property type="nucleotide sequence ID" value="XM_006695416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDD3"/>
    <dbReference type="GeneID" id="18259176"/>
    <dbReference type="KEGG" id="cthr:CTHT_0051380"/>
    <dbReference type="eggNOG" id="ENOG502SFKU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055491_3_5_1"/>
    <dbReference type="OMA" id="IWTAGKL"/>
    <dbReference type="OrthoDB" id="5320223at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS18534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="136" mass="15009" checksum="4246E21561DAC3B7" modified="2011-10-19" version="1">MPLTGHCLCKAVTYTVDVDAPILTGYDHCDDCQRQSGSTYSLVCVVPKDKFTSQGPLKKWKGIADSGNAVWRWFCAECGSPIAHDPEGAPEIIALKGGSLDMEIKKTLKPDTEIWTVSKLPFCQENLAKPFKYMPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDG7</accession>
    <name>G0SDG7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">rRNA methyltransferase 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0051720</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695513.1">
        <property type="nucleotide sequence ID" value="XM_006695450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDG7"/>
    <dbReference type="STRING" id="759272.G0SDG7"/>
    <dbReference type="GeneID" id="18259210"/>
    <dbReference type="KEGG" id="cthr:CTHT_0051720"/>
    <dbReference type="eggNOG" id="KOG0838">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021322_5_2_1"/>
    <dbReference type="OMA" id="IHANENR"/>
    <dbReference type="OrthoDB" id="270651at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18105">
        <property type="entry name" value="SpoU-like_MRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047182">
        <property type="entry name" value="MRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047261">
        <property type="entry name" value="MRM1_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46103">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46103:SF1">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="RNA 2-O ribose methyltransferase substrate binding" evidence="11">
        <location>
            <begin position="321"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="166"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="190"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="249"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS18568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="638" mass="70314" checksum="B08F7D17BC5CAF35" modified="2011-10-19" version="1">MLPLTLQAARRPIPRLPNVRLTRPASILSAIREGIVKEEHSNPQGPDIERLKQLAAEGKKLTYKQRQQLREALEAERPTYRIRKGKKDITEDPVEEVLGPDAKTRKARFYDPQESFGKDSIVWKLKATGMVEKYRELQKQMGGKATALAARKAALEVFKEGGLIDEERARGKYDDDDDEMEKKGRKKRSGRIDADDMFAELEREVSPQKESDPFAEMEREVNRAKKLSESRGKDTRSEWAVTSDGKSTMPEEVKKARDRPRERGNGRVNEHKNRDNKRDSQSAREDENENRNENGNADESKYPRKFRFPLSIPYTTAASQFLYGKSVVEAALLSARRKLYHLYMTDLHQRKDPSGSRAMLALARSKGVPVTILSDADKRLMDKMAEGRPHNGFVLEASPLPQPPVTALGPLPSSEDGVPKPITEIPVTLDHQSAEDASINGTSPSLPLPSPLIPGYNPLILILDRILDPGNLGSILRTSLFLGASAVGITRHGSAPLSPVTLKASSGAAESLPLFIIPSLPHFLTTTRQNGWTVFAACARDPSVRKNRRHWDLDDVRREEPLRKGGCVLVLGSEGEGLERATVKKADYEVAVPGGGGAAQRVGVESLNVGVAAGLVVEAFMGGVLKAKEGSSGSGELW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDQ2</accession>
    <name>G0SDQ2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Enoyl CoA hydratase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0052590</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695598.1">
        <property type="nucleotide sequence ID" value="XM_006695535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDQ2"/>
    <dbReference type="STRING" id="759272.G0SDQ2"/>
    <dbReference type="GeneID" id="18259297"/>
    <dbReference type="KEGG" id="cthr:CTHT_0052590"/>
    <dbReference type="eggNOG" id="KOG1681">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_0_1"/>
    <dbReference type="OMA" id="QYVAHVE"/>
    <dbReference type="OrthoDB" id="14970at2759"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051750">
        <property type="term" value="F:delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000004">
        <property type="entry name" value="Delta3,5-delta2,4-dienoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000024">
        <property type="entry name" value="Delta3,5-delta2,4-dienoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045002">
        <property type="entry name" value="Ech1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149:SF1">
        <property type="entry name" value="DELTA(3,5)-DELTA(2,4)-DIENOYL-COA ISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS18653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="286" mass="30799" checksum="9D9566A0AF59A5CC" modified="2011-10-19" version="1">MAQAKPLAAYSSYKYFNVTSPSPYVAHVEINRPEKLNAFHEAMWLEMKRVFDQLSVDPEVRAIVLSGAGERAFSAGLDVVAASEGSILNNKDGLDGARTATKLRRHIAEFQDSISAIEKCEKPVICVLHGISIGLSIDISCCADVRICAKDTRFAVKEVDIGLAADIGTLARLPKVVGSFSWVKDVALSARDFGAAEALQVGFVSQVCDNKAAALAAAFEKAAFIASKSPVAVQGTKELLNHSRDHSVAENLRYTGVWNSAMLQTQDVAAALLSGMQKRKPTFEKL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-06-24" modified="2025-04-09" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDQ4</accession>
    <accession>G0ZGU8</accession>
    <name>NUP85_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleoporin NUP85</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Nuclear pore protein NUP85</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">NUP85</name>
        <name type="ORF">CTHT_0052610</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. NUP85 is involved in nuclear poly(A)+ RNA and pre-ribosome export, in GSP1 nuclear import, in NPC assembly and distribution, as well as in nuclear envelope organization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 6">Component of the nuclear pore complex (NPC). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof.</text>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-16069259">
            <id>G0SDQ4</id>
        </interactant>
        <interactant intactId="EBI-16069391">
            <id>G0S2G1</id>
            <label>ELYS</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>7</experiments>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-16069259">
            <id>G0SDQ4</id>
        </interactant>
        <interactant intactId="EBI-16069242">
            <id>G0S0E7</id>
            <label>NUP120</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>15</experiments>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-16069259">
            <id>G0SDQ4</id>
        </interactant>
        <interactant intactId="EBI-16069276">
            <id>G0SAK3</id>
            <label>NUP145</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>7</experiments>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Nucleoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="1">Symmetric distribution.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nucleoporin Nup85 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JF276291">
        <property type="protein sequence ID" value="AEL00686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695600.1">
        <property type="nucleotide sequence ID" value="XM_006695537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDQ4"/>
    <dbReference type="SMR" id="G0SDQ4"/>
    <dbReference type="DIP" id="DIP-60570N"/>
    <dbReference type="IntAct" id="G0SDQ4">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0SDQ4"/>
    <dbReference type="TCDB" id="1.I.1.1.2">
        <property type="family name" value="the nuclear pore complex (npc) family"/>
    </dbReference>
    <dbReference type="GeneID" id="18259299"/>
    <dbReference type="KEGG" id="cthr:CTHT_0052610"/>
    <dbReference type="eggNOG" id="ENOG502SIA5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002336_1_0_1"/>
    <dbReference type="OMA" id="YKPSPAC"/>
    <dbReference type="OrthoDB" id="5422384at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011502">
        <property type="entry name" value="Nucleoporin_Nup85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373">
        <property type="entry name" value="FROUNT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373:SF21">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07575">
        <property type="entry name" value="Nucleopor_Nup85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0509">mRNA transport</keyword>
    <keyword id="KW-0906">Nuclear pore complex</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000433178" description="Nucleoporin NUP85">
        <location>
            <begin position="1"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Bipartite nuclear localization signal" evidence="2">
        <location>
            <begin position="103"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Bipartite nuclear localization signal" evidence="2">
        <location>
            <begin position="155"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="95"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P46673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="21784248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <evidence type="ECO:0000305" key="6">
        <source>
            <dbReference type="PubMed" id="21784248"/>
        </source>
    </evidence>
    <sequence length="1169" mass="128126" checksum="62A6AB306F30AE41" modified="2011-10-19" version="1">MFRVPDDSILSSSPAPSTPDKSRRAGSSNLFRDSTASSAASTTPAGTPPVKFLGSSIMRPSDKNASSSVDDDQPAVGLFTGIGGGVGVGMGAGTGATAAAKAAKKNLFAAVSGERRRNVPLGRSGRGHDSRQPSRLRKSIGVDDLEDEEEEEEKKKKPQLLKPKGKVQEKKKDEPVRGLFTGTSLAPPPLSKAAAAATTTTTTGPTKSFGLTYEEFGESEEEDSGLTGGQDAEGELDDSMWLERSPERPAIGDESDLLLMATPAATERVRREAEDIFRATAMGAGATTRRHEYRYASLAKDVYTQLGTAPLVEPPQLILSTEALLEQLYDEGVGTHDDDARLDETLAAVAVQLINLWQDHVDAIAQPEEDGHVADIGPGPRASPFEKAYWLATLALQLHHTRALDGGVEPLPATLFQWLNDRHDMYAGQVEEILRYRPSPACHSLFWQAVFMSLLRGRVKDATQLLRRAGWEHVRRGGQQRGEYAYSDRALENVLRVVDETVSVLESCPGYDGNWEIWSSEWTLFRVRAQGALEHLRRFAEGKDTSFGDSLFGSSTGSNRGYTGYRDHTLAGLARRAESQVPWDVYESLNVVFDIVLGQQASILEAAQDWLEATIGLFGWWDERNNNNNNNNNNNNNNNGYQKPGRTQALVLHSSPAHHINNDSESYLDRLARAFHAAVASDFHFNSQNPVEIGMACIFEDNIKGVIGLLRSWSLPIAAAVAQVASLGRWLPPHRPKGMYALEDLDMDDLEVLGVDPGAPDEVDGVKDSTLVQYAQALVEYEGLETVRDRAGVYREGWELAISVLGRMDSPERSEEMVRDIVEHLVQGLTVDSTETVDRLWTMLNELSMITYAEEMTETFGDILARESHRYGEAMWYYALAHRPNKVREVMNLLISYSLIQSTAFPPAADLDDYLHRLLSDRKHTLEQYAKQDMEAAELLGKMLSGYAALRQFYDIRDNVDATSISPVSRRQQAAAALISVIASSDDNIRGGLVDQTRDGIVSEDFLLALLGEALVFVSNPDNTFVHHGHAAVPILSQDQIDVLLKAVEDLTAVSERVYNVCDEFLQLVLASAPGGALKGSKPADLLKKGQDGQQMVLAGSSLIASQLQKSLLGGSGSALGKVPVKRGWDWREGMPAKMKGEDVIRRLRLGLAKDLARLWLAEADALVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0SE13</accession>
    <name>G0SE13_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0062050</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696521.1">
        <property type="nucleotide sequence ID" value="XM_006696458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SE13"/>
    <dbReference type="GeneID" id="18260243"/>
    <dbReference type="KEGG" id="cthr:CTHT_0062050"/>
    <dbReference type="eggNOG" id="ENOG502S8DA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122021_1_1_1"/>
    <dbReference type="OMA" id="VISRAWY"/>
    <dbReference type="OrthoDB" id="202672at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024512">
        <property type="entry name" value="Ser_palmitoyltrfase_ssu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11779">
        <property type="entry name" value="SPT_ssu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS18190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="124" mass="13906" checksum="47E5D7A50B9BDA3A" modified="2011-10-19" version="1">MAQPPSISTKPASSRVEAFKNWLKLKHYQFEVTFSVYTFTRGEKVFFYMVLLLLISLTLAATILYLPRHVRFVISRAWYYIHGEAPPFGGAESDISFLATTAKRVMDSAAAAVEKAAAAGRREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEC8</accession>
    <name>G0SEC8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0063290</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696636.1">
        <property type="nucleotide sequence ID" value="XM_006696573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEC8"/>
    <dbReference type="STRING" id="759272.G0SEC8"/>
    <dbReference type="GeneID" id="18260367"/>
    <dbReference type="KEGG" id="cthr:CTHT_0063290"/>
    <dbReference type="eggNOG" id="KOG0601">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009707_0_0_1"/>
    <dbReference type="OMA" id="DSIVRWM"/>
    <dbReference type="OrthoDB" id="5337378at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110031">
        <property type="term" value="P:negative regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000611">
        <property type="entry name" value="Protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF196">
        <property type="entry name" value="MITOSIS INHIBITOR PROTEIN KINASE SWE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="812"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="283"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="611"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1161"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="284"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="349"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="396"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="413"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="434"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="479"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="538"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="624"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="684"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1174"/>
            <end position="1184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS18305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1184" mass="127247" checksum="40A10C244D7EAB81" modified="2011-10-19" version="1">MSYSSTSGGTLTLPSPTHPHNVDVSSAVRSLRRSLSRSPSKFRLSSTASPTLTSTPMTSSIFRQPLTPAPTDRSLFSDQPGPATGASSTPIPATPAGPAEPSSPKAAAFTAPPPLPAATPLLRSNIKLSLRSTRSAKPITRPLGRQRLSPRKSPLKRVFGPAPDSGNPIPSASSSSSSSSDCEDNDQENLDLPSGAESPIELSPTARRSSERRSFERANRLSFSLESNGSGKSGMAKFLDNEDKSTFPSISVSPLKRSDAAMSVDQPTFGSPVAKRRSLHGISGVSNGVSVFDQNPASTTPTNMATKDSSNGAFDTQDDGNQEYRLTGTTASPFRDPVASPTPTVMPKRTSSLRKSTLQQRLGESRGALSRRAGEKQISQLADGASTPIPRNRLRLSLDHYTPTEERVNLFGSPAPSSSLAQPAPRPANQPHPLSRSLTQSSSSSSQPDDSPTHVPVSHIGERPRVPLNFSKSLPPGSQRPTSDSQMTPQYKQAKPLQSAFLSTGLVSKMNRNPDLLPPKHSGFKMSQMPDTPCKKQPYNSNTFPPQGTSGGRRQRISLGSPSTPFSGLVAPIRENNPFGSQDKSGSFLFQQVRNGPGRKSSVLSLDGDELVGSHDDFPPPTPTKNVLFNKSSTTPVPSARDEQRESYTPFGTPVPGFGLGRIDDTPSKIGPTQKDRAVEGITRPTTPFSGASPSLSFSLGLNNSRSQPASFATPAPNRTGPASFGVFGQYTRNEATKTPLGKENRPPQTPQDGSVMPDPCSRSISARPPPATPTGSQPPSLFSSVIDRRLSVTPQNRHGPVEVDESLMSRFDKSELIGSGEFSQVYRVVKASAPSMFLTGFSTTPRTPSSPDDNSRVFAVKKLKLPFHSAREREAKMKEVHILQTLSHSSKIVQFIDSWEHNGHLYIQTEYCSEGSLDAFLREIGQCGRLDDFRIWKILLETTQGLMAIHQAGFIHLDIKPANIFITFDGYLKIGDFGMATSWPAPKGIEGEGDREYIGPEILLGQYDKPADIFALGLIILEIACNVFLPDNGPTWQALRNGDMSVVPPLTPGEAGAVLRDANGVPICNDSGVSMPDEDSSFAFKGMTHDASNLFGSQRRPELREPPPFLADPNHPHSLDNLVKWMIQPNPKDRPTAEQLLASEPVTWISSRRAAGATVFEGNWGPQVGPSVQEGSDTEMTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-12-14" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>G0SED7</accession>
    <name>G0SED7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0063380</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696645.1">
        <property type="nucleotide sequence ID" value="XM_006696582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SED7"/>
    <dbReference type="GeneID" id="18260376"/>
    <dbReference type="KEGG" id="cthr:CTHT_0063380"/>
    <dbReference type="HOGENOM" id="CLU_1098385_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="253" mass="27851" checksum="C1F62642942F5195" modified="2011-10-19" version="1">MKLTDSQRKAVRKAGQAAYRAARRSSLLRPYSYRTPLIRKGEAGLPSLAAPEDPPPHQTTRGSSLTPHKPRRTGCRSPTAAPLHRAHTEPPTSSLPARSSDRSSVRLIKETSEILIKKCCDFPQLVNFLSFGSRLWEKCAASALLLLDTFWESETTHFLLEEWASLRQEKEAELSRKTRVGIRGSIGGLSTGAPANRSYVDKCLVNEEFQTFNPSAQLPRNNLSLFSSASTPTPSSSESVSGLEIHIPGVVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0SES3</accession>
    <name>G0SES3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HhH-GPD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0059520</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS17939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696270.1">
        <property type="nucleotide sequence ID" value="XM_006696207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SES3"/>
    <dbReference type="STRING" id="759272.G0SES3"/>
    <dbReference type="GeneID" id="18259990"/>
    <dbReference type="KEGG" id="cthr:CTHT_0059520"/>
    <dbReference type="eggNOG" id="KOG4161">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017748_0_0_1"/>
    <dbReference type="OMA" id="CKEGHRE"/>
    <dbReference type="OrthoDB" id="10265068at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045138">
        <property type="entry name" value="MeCP2/MBD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074:SF0">
        <property type="entry name" value="METHYL-CPG-BINDING DOMAIN PROTEIN 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074">
        <property type="entry name" value="METHYL-CPG-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="4">
        <location>
            <begin position="297"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="149"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS17939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="526" mass="59446" checksum="41D26FF488BC1545" modified="2011-10-19" version="1">MTDSPTLHIDDLLYSFNVQNDNLRQFLCDLLASGKVPLRVVDELKGFSLMRGVEGWEMIFEATEELRQRDGKSSEGDDEAGREHKEGEKRKLENWRQRRFGREVSHFFGDDVEENGRGRARRCKEGHRERSQLRGSGCVSFETLPYGEEATDMSTEVKTEQAEAPAYDRLSDNGLGSDPALDLEQTQDISTDDQGSAHLLSPHSTSRTGKESSSISRSLRATKSPFFVPLTPSPNNTHSRQLLSSSSSPHHKRKRPPRGTVSSLPIPPLSSPRFGLIQEDLADDPFALLIAVTFLIRTTARQALPVFRQLMARWPTPEALASADEDQIVMLIKPLGLSQIRCAAIKRYARRWVEMGPPSRERRYGVVGYPEMGDGVGFVKMGEDYGPEDDEEAAAAAKEGDVVTDAKRRGVGYAWEIGYLTQGAYAIDSWRIFCRDVLLGRSKHWTGWGSEREGFQPEWMRVLPKDKELRACLRWMWMKEGWEWDPVTGEKQPLREELRRAVDEGRVRYDDLGNLVIVDEGAQSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0SES8</accession>
    <name>G0SES8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0059570</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS17944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696275.1">
        <property type="nucleotide sequence ID" value="XM_006696212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SES8"/>
    <dbReference type="GeneID" id="18259995"/>
    <dbReference type="KEGG" id="cthr:CTHT_0059570"/>
    <dbReference type="eggNOG" id="ENOG502SRDU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049367_0_0_1"/>
    <dbReference type="OMA" id="QEWDECA"/>
    <dbReference type="OrthoDB" id="5334491at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="260"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="329" mass="35880" checksum="CC571DF333BBA4B0" modified="2011-10-19" version="1">MLLPSALPSDSSQQPWTQPQPQTQAPSPAPPPLMTRIQTALFNSPPPSPPRLSTENAFGSVFNSCRTLQALIAAGNQPSPPLEPSVEPITPPDLSFSELPTPPLAPAASPPLKLRLRARRTENNKDTTGATNGEHGPQRMKIHKRSAAGGTARGHGLKRRRPAVEEDTLARESAGEESMSDIEGGQLLGSATSSFSAQPHLPREQKLPPLPRTPRRSRIAPEVLPLGLERSDFHTLASEQGPQVNNEPKGTDIVTESDGSTWSIEEDRVLVELVLEKLKLSKEDWQDCARSLGKDRSSLGRRWKSLMINGDIGLKKNGSRRARLYGTWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEZ9</accession>
    <name>G0SEZ9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF1750-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0060280</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696346.1">
        <property type="nucleotide sequence ID" value="XM_006696283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEZ9"/>
    <dbReference type="STRING" id="759272.G0SEZ9"/>
    <dbReference type="GeneID" id="18260066"/>
    <dbReference type="KEGG" id="cthr:CTHT_0060280"/>
    <dbReference type="eggNOG" id="ENOG502S04K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013398_0_0_1"/>
    <dbReference type="OMA" id="RKEFMLH"/>
    <dbReference type="OrthoDB" id="5321006at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013859">
        <property type="entry name" value="Ssr4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046464">
        <property type="entry name" value="SWI-SNF_Ssr4_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20497">
        <property type="entry name" value="SWI-SNF_Ssr4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08549">
        <property type="entry name" value="SWI-SNF_Ssr4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWI/SNF and RSC complexes subunit Ssr4 N-terminal" evidence="3">
        <location>
            <begin position="9"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="SWI/SNF and RSC complexes subunit Ssr4 C-terminal" evidence="4">
        <location>
            <begin position="285"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="481"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="577"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="705"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="380"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="592"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="659"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS18015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="765" mass="81292" checksum="2FEBFDA00BC37D76" modified="2011-10-19" version="1">MANTMAVVDPSQNVHGDLLPHIHLISTFRYATMPRVELQEVTKWLLQAPKIARDTSPFYWTYLDCPADGSILLTWQPTARRGTEFATDGYIWAGPEVQFQQNMGNGLLLEIYFQRAGYRMGEQYAVHSRRRFRLLLAPGQAPNPNLQVDPNLWIVHYGPAEKNDRLPVSAIVLPPPIHQLLNFRQHLLSMGQIIRKEFMLSDRVNWPQIPFPTRATSMYAPPIPQRHIPQAMAYPPHPGQPIAPAPKRRGGQSSSSSSAAAAAAAAAAQAAQMAGAAAGYHPDVFNDEEDVSAGDMFDHLTPRELSLARYQQNHEWMEEILLSPYQIGQIEVSDLGLGKKGELAALTEGIFEAQGFDALQRGPKKPYTGKLDPGLADEFRKRVEERNAAVKAEIEEMKAKHEKMMAKFKRSAVIKQAEQELRFAVQETGTEFWRLEGKIDEGEEAPSQKIITKSLDEIVARVEELVGKHATVVKDVHRIQDGGYQEPQPEPPAPTAAPSAGAVGDMSCQASHAGSNGSGVLIGSDHDIDMGGTAGSLLDQMHSSAGFSSTSTPMNNFPTPQAHLPVSSIPSSAATPGVVSVSSPNPVPPTAGVPAAQVQQQQDVQMGGTEPAAVVPAKEATTATEQGISSGEGDWVVVGKEGIPPAPGPSNITQPPAAPATAPLATTPAATGPGGAPTPGSTALIETDFADLDTAGDALASYEAAAAGSGSQNGDDHEGGRLEDEEDMDMMVGGEESAFGEAFEGVEAANAAVGQGGVEGGGDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0SF73</accession>
    <name>G0SF73_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0061040</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-K/MCM22 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696420.1">
        <property type="nucleotide sequence ID" value="XM_006696357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SF73"/>
    <dbReference type="GeneID" id="18260142"/>
    <dbReference type="KEGG" id="cthr:CTHT_0061040"/>
    <dbReference type="eggNOG" id="ENOG502RXW1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048926_0_0_1"/>
    <dbReference type="OMA" id="IAQFHPK"/>
    <dbReference type="OrthoDB" id="9445768at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020993">
        <property type="entry name" value="Centromere_CenpK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14401">
        <property type="entry name" value="CENTROMERE PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14401:SF6">
        <property type="entry name" value="CENTROMERE PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="222"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="14"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="102"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="227"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS18089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="331" mass="37306" checksum="860AD58870138442" modified="2011-10-19" version="1">MEMEVDPSPQRRSDRTYEAQLERTIQELKSIEKQLEDAIQQLRSDSAVGADSSATESVEIMTKAFQHLAESEPILPSPGSVLPALLAMRRAHQTIQESQECAAAQAQSLEQIQRRIETEKANLCEQEALRTALENRLKSLREGLEDEGEKSEDQLSKERIAELKKQKEHWDKQTSTLMKQLDQFIEEYLGPMLAAEDLGGPVVGDMIDINPNDLEAGFTTHGKLKKTKGESDQDKRQRRIDEMWAPMDSQGEAGKKRPRDEASAAAAEMRDLLEQLMNKLIEARGDNSAAYVELPRESAAARFLVRSKVAMFDPKDARKIRLVDFGREVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0SF81</accession>
    <name>G0SF81_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0061120</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696428.1">
        <property type="nucleotide sequence ID" value="XM_006696365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SF81"/>
    <dbReference type="GeneID" id="18260150"/>
    <dbReference type="KEGG" id="cthr:CTHT_0061120"/>
    <dbReference type="eggNOG" id="ENOG502SQ86">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_409926_0_0_1"/>
    <dbReference type="OMA" id="WPAVRIN"/>
    <dbReference type="OrthoDB" id="4589765at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024119">
        <property type="entry name" value="TF_DEAF-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237">
        <property type="entry name" value="DEFORMED EPIDERMAL AUTOREGULATORY FACTOR 1 HOMOLOG SUPPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237:SF14">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="196"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="639"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="649"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS18097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="670" mass="76510" checksum="AEC13BB26C2CCC31" modified="2011-10-19" version="1">MRQEEKAPFEGEKILDIPKDPKPKLIEDVPVLPDLPVSLEGKRESENTSPAQTPSKPKEKRELFSTKWKLTRIKEEWEVREFRPPSPPTVPTASLSDLMLGPSVTEAYLAKNKGKQLQSENGKPVANVWYWNAVEPESAHLGRIPGESIGMVSYINPDFEAFVNELASSDPEEDLKRVKADIDDAYQNHRVVDNLCVSCENQGLKQCNLCKLARYCSKECQTADWPMHKKVCKGFAVETADNARPSPKHRRILFFPAYDPKPKLLWAVPELVGERNVIRVEHPDIEKFWNAVRESENDLLDKWIQIARINLHPPFKSRRIGTTLLVQYYGIKFPRPKSFVHVNRSINAISEPGYLRPFFGPVLVFSDEGKSDPRDQEIRDITPREVHTAVRFFETLDCPCLKDPKQWPSEVISGIKVSDLRLGLNVAMGIQQPYEPVYVPLQPIKQIDSPIALAFLLGLRWYLRDCNYLSREYGANMWSDLKLFYLGITAVVDQQFYANVKKTDHGRQVQGATGDSTFVNPVRPFGRPSFIPGRFIGSMIVLHGSGKPLDIAHLLCFDNYMQDVFSRAETPSKEGFEGFWEKWRVGANGNLLQLSSPYELEKDEIKDRLGWFNPKLVMETIGQHKEELLAVVKKEAKAMMGKQTSSRGGQEKHNLREEWERKVAEEGLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0SF86</accession>
    <name>G0SF86_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0061170</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696433.1">
        <property type="nucleotide sequence ID" value="XM_006696370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SF86"/>
    <dbReference type="STRING" id="759272.G0SF86"/>
    <dbReference type="GeneID" id="18260155"/>
    <dbReference type="KEGG" id="cthr:CTHT_0061170"/>
    <dbReference type="eggNOG" id="KOG1693">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066963_4_2_1"/>
    <dbReference type="OMA" id="VGEYTFC"/>
    <dbReference type="OrthoDB" id="1929172at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409182" description="GOLD domain-containing protein" evidence="10">
        <location>
            <begin position="21"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="32"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS18102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="210" mass="23696" checksum="233551EC38B27226" modified="2011-10-19" version="1">MQLPLLSCSLLALFAAQATATALTYKLGANEKACFYTLTQHKDEKIAFYFAVQSGGSFDVDYEVTGPNGRYIMSGEKERQGDFVFTARDVGEYKFCFNNGMSTFAEKFVDFEISVENEARVTLPSKQGASPEQTSALEESLFKISSQLSTITRNQKYFRTRENRNFSTVRSTEKRIINFSLVQIALIICMGALQVFIVRFFFQGARKGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFG2</accession>
    <name>G0SFG2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oxidoreductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0070700</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697345.1">
        <property type="nucleotide sequence ID" value="XM_006697282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFG2"/>
    <dbReference type="GeneID" id="18261108"/>
    <dbReference type="KEGG" id="cthr:CTHT_0070700"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010119_6_1_1"/>
    <dbReference type="OMA" id="FWHVGRE"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000030">
        <property type="entry name" value="Thymine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF804">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="187"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS17727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="342" mass="38134" checksum="F3691C7EC8555E09" modified="2011-10-19" version="1">MEKAAVQGDGLLIPLIDFSKFLNGSSSQKLSTAQAILRGFQTAGFIYLSNIPIPPSVVSQVFSYSATFFKLPMSEKLNIAWTTPEANRGYSAPGREKVTILTDEAAVDALRKSVPDMKESIEIGREDEPEHPNRWPVETKENNLVGFRELMLSFFDQCASLHKQIMRAIAVGIGIEEEYFDSFVCDNDNTLRLLHYPSVPKKVFDENPSQVRAGEHTDYGSVTLLFQDQRGGLQVKSPNGQFVDAAPIEGTCVVNAGDLLARWSNDTIKSTLHRVVRPPGGLLKGEDGEEWFPARHSVAYFCNPNFKDFIEAIPGTYKTEEDKKYPGINSGEYLVQRLRATY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFP2</accession>
    <name>G0SFP2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pentatricopeptide repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0071570</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="AlphaFoldDB" id="G0SFP2"/>
    <dbReference type="STRING" id="759272.G0SFP2"/>
    <dbReference type="GeneID" id="18261195"/>
    <dbReference type="KEGG" id="cthr:CTHT_0071570"/>
    <dbReference type="eggNOG" id="ENOG502QQWX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014304_2_0_1"/>
    <dbReference type="OMA" id="CVRDNIN"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="142"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="47"/>
            <end position="86"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="383"/>
            <end position="453"/>
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    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="725"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="391"/>
            <end position="427"/>
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            <dbReference type="ARBA" id="ARBA00006192"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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            <dbReference type="ARBA" id="ARBA00044493"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS17807.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="768" mass="86576" checksum="826A98DB8485A3D9" modified="2011-10-19" version="1">MYVCRACLRSLSGASITPVQSRLVQPLCRPPVGLGPYRRWYRVGAGANAPSSTSAVEDRENENEKRKESEDGDAKTKANAAEEDKAEGKKRYEKKLEWVVKKHLQWLGNEYLVAQHVHKALSKGSFEEALLLTRMASRKMKVEVAWNHLIDYHMKKGRLHAAVKLYNEMKKRAQIPNAKTYTIIFRGCAQSLHPKLAVSEATRIYNFMLNLGSLKPNTIHMNAVLEVCARAGDIDSLLTVLKSANETVRAPDAHTFTIVLNALRYDVKKLENGRLGLVDQEVQEEIQRNVGKARALWADVLARWRSGRLLLDEPLVVAMGRILATGDYKDCDSILDLMEETMKVPRLDRVGAKLPNPPPDVSAVDEMPSAPILEKELKRQAEQAKLQVTKASEDAKRMTEEESQGKPEGMETDDVKGKEENREHNDDIPQVDVSDLSPKKRRELAASRPKGAPLYAKPGNKALSLALTSLARTRKTSHAHKYWEYFTKSLNVTPDADNWYCYLRALAVGHASAAVADVVHAMPADIVSPITFRIAFGACVHDNLNPDAFSNACRIFEAMMAKMRYPDPLSMRLFLHVARLNKRHIYDKAIRAIEKIKADPSLSTIERLTKERQTRKAADVAYGKQLIRAVDVLWEPFRILVSSFSYPAASEPATGSPEQEVDLKRNDMQEAMATARRMISAIDIVTNQEMFPSESKEQLIQSILKPRRVVLQRLVERYILKLYPQGPPPEKKKKEFDDDEEPTRLPRGIFDAFTEEARLAQGRMAGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGY1</accession>
    <name>G0SGY1_CHATD</name>
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        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0067970</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="476" last="476">
            <title>High-resolution structures of a thermophilic eukaryotic 80S ribosome reveal atomistic details of translocation.</title>
            <authorList>
                <person name="Kisonaite M."/>
                <person name="Wild K."/>
                <person name="Lapouge K."/>
                <person name="Ruppert T."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="35079002"/>
            <dbReference type="DOI" id="10.1038/s41467-022-27967-9"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.90 ANGSTROMS) IN COMPLEX WITH MG(2+)</scope>
    </reference>
    <reference evidence="13 14 15" key="3">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e56910" last="e56910">
            <title>Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation during pre-60S biogenesis.</title>
            <authorList>
                <person name="Lau B."/>
                <person name="Huang Z."/>
                <person name="Kellner N."/>
                <person name="Niu S."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
                <person name="Cheng J."/>
            </authorList>
            <dbReference type="PubMed" id="37129998"/>
            <dbReference type="DOI" id="10.15252/embr.202356910"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <reference evidence="17 18 19" key="4">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e57984" last="e57984">
            <title>Structural insights into coordinating 5S RNP rotation with ITS2 pre-RNA processing during ribosome formation.</title>
            <authorList>
                <person name="Thoms M."/>
                <person name="Lau B."/>
                <person name="Cheng J."/>
                <person name="Fromm L."/>
                <person name="Denk T."/>
                <person name="Kellner N."/>
                <person name="Flemming D."/>
                <person name="Fischer P."/>
                <person name="Falquet L."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="37921038"/>
            <dbReference type="DOI" id="10.15252/embr.202357984"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.12 ANGSTROMS)</scope>
    </reference>
    <reference evidence="11 12" key="5">
        <citation type="journal article" date="2023" name="Nat. Struct. Mol. Biol." volume="30" first="670" last="677">
            <title>Structural inventory of cotranslational protein folding by the eukaryotic RAC complex.</title>
            <authorList>
                <person name="Kisonaite M."/>
                <person name="Wild K."/>
                <person name="Lapouge K."/>
                <person name="Gese G.V."/>
                <person name="Kellner N."/>
                <person name="Hurt E."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="37081320"/>
            <dbReference type="DOI" id="10.1038/s41594-023-00973-1"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.20 ANGSTROMS) IN COMPLEX WITH MG(2+)</scope>
    </reference>
    <reference evidence="16" key="6">
        <citation type="journal article" date="2024" name="Nat. Commun." volume="15" first="716" last="716">
            <title>Methionine aminopeptidase 2 and its autoproteolysis product have different binding sites on the ribosome.</title>
            <authorList>
                <person name="Klein M.A."/>
                <person name="Wild K."/>
                <person name="Kisonaite M."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="38267453"/>
            <dbReference type="DOI" id="10.1038/s41467-024-44862-7"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.10 ANGSTROMS) OF 2-187</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697088.1">
        <property type="nucleotide sequence ID" value="XM_006697025.1"/>
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        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="LP=1-187"/>
    </dbReference>
    <dbReference type="PDB" id="7OLD">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="LP=1-187"/>
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        <property type="chains" value="LP=1-187"/>
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    <dbReference type="PDB" id="7Z3O">
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        <property type="resolution" value="3.30 A"/>
        <property type="chains" value="LP=1-187"/>
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    <dbReference type="PDB" id="8I9P">
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        <property type="resolution" value="3.00 A"/>
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        <property type="chains" value="LP=1-187"/>
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    <dbReference type="PDB" id="8I9T">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.60 A"/>
        <property type="chains" value="LP=1-187"/>
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        <property type="resolution" value="2.80 A"/>
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        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="LP=1-187"/>
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        <property type="chains" value="LP=1-187"/>
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        <property type="resolution" value="2.63 A"/>
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        <property type="resolution" value="2.80 A"/>
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        <property type="resolution" value="2.90 A"/>
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        <property type="resolution" value="2.86 A"/>
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        <property type="resolution" value="2.94 A"/>
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        <property type="resolution" value="2.12 A"/>
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        <property type="resolution" value="2.91 A"/>
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        <property type="resolution" value="2.55 A"/>
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        <property type="method" value="EM"/>
        <property type="resolution" value="2.19 A"/>
        <property type="chains" value="LP=1-187"/>
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    <dbReference type="AlphaFoldDB" id="G0SGY1"/>
    <dbReference type="EMDB" id="EMD-17004"/>
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    <dbReference type="EMDB" id="EMD-35289"/>
    <dbReference type="EMDB" id="EMD-35290"/>
    <dbReference type="SMR" id="G0SGY1"/>
    <dbReference type="STRING" id="759272.G0SGY1"/>
    <dbReference type="GeneID" id="18260835"/>
    <dbReference type="KEGG" id="cthr:CTHT_0067970"/>
    <dbReference type="eggNOG" id="KOG3353">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083987_0_0_1"/>
    <dbReference type="OMA" id="NTYETAR"/>
    <dbReference type="OrthoDB" id="10254664at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.10:FF:000010">
        <property type="entry name" value="60S ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_uL22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005721">
        <property type="entry name" value="Ribosomal_uL22_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01038">
        <property type="entry name" value="uL22_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593:SF10">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9 10 11" id="KW-0002">3D-structure</keyword>
    <keyword evidence="9 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="binding site" evidence="9 11 12">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS17470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="7OLC"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="7OLD"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="7Z3N"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="7Z3O"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="8I9P"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="8I9R"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="8I9T"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="8OO0"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PDB" id="8PV1"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PDB" id="8PV2"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="19">
        <source>
            <dbReference type="PDB" id="8PV3"/>
        </source>
    </evidence>
    <sequence length="187" mass="21034" checksum="B593858015ED6F6D" modified="2011-10-19" version="1">MVRYAATEIAPTKSARARGSYLRVSFKNTRETAQAINGWKLQRALTFLQNVIDKKEAVPMRRYAGSTGRTAQGKQWGVSRARWPVKSAQFLIGLLKNAEANADAKGLDTGNLIIKHIQVNQAPKQRRRTYRAHGRINPYMSNPCHIELILTEAEETVQKSEAVVRDVESHLSSRQRGVRIRRALTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGZ3</accession>
    <name>G0SGZ3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Reductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0068090</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697100.1">
        <property type="nucleotide sequence ID" value="XM_006697037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGZ3"/>
    <dbReference type="STRING" id="759272.G0SGZ3"/>
    <dbReference type="GeneID" id="18260847"/>
    <dbReference type="KEGG" id="cthr:CTHT_0068090"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="OMA" id="EFHSCDV"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF12">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_1G14540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS17482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="282" mass="29124" checksum="B969551DD5C006CE" modified="2011-10-19" version="1">MAEAQLHDFPSLFSLEGKVAVVTGGSRGLGLSAASAFLQAGCSKVFISSRKAAACDNAVKVLNALPNLRPGAVAISVPADGSTLEGVKHLLAQVSAHTDHVDILMANAGATWGEKFDTHPDSAFAKVMDLNVRGVFNLVREFAPLLTKRASVEDPSRVIITASVAGLGVGSLGKQGTYGYSASKAAVIHLGRNLAVELGPRGITVNSICPGFFPSKMSNGLLEMAGGVQKMAEANPMRRLGRSEDIAGAVVYLASRAGSHVNGAAIEIDGGALWSHGQLLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G0SH28</accession>
    <name>G0SH28_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0068470</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cerato-platanin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697135.1">
        <property type="nucleotide sequence ID" value="XM_006697072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SH28"/>
    <dbReference type="GeneID" id="18260885"/>
    <dbReference type="KEGG" id="cthr:CTHT_0068470"/>
    <dbReference type="eggNOG" id="ENOG502SQTH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111635_0_0_1"/>
    <dbReference type="OMA" id="QCGTCYG"/>
    <dbReference type="OrthoDB" id="4898945at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22778">
        <property type="entry name" value="DPBB_CEPL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010829">
        <property type="entry name" value="Cerato-platanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07249">
        <property type="entry name" value="Cerato-platanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409239" evidence="4">
        <location>
            <begin position="19"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS17517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="138" mass="14609" checksum="F3AA6A5394F61515" modified="2011-10-19" version="1">MQLTKLASILFYATATSAITVSYDTGYDDATRSLAAVACSDGTNGVMWKYNWKVQGDVKNFPFIGGSEAIGGWNSPNCGTCWAATYNGRTIHILAIDHAAHGLNIGLTAMNALTNNKAVELGRVDAHVVQVPLSNCGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0SH81</accession>
    <name>G0SH81_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0069050</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697188.1">
        <property type="nucleotide sequence ID" value="XM_006697125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SH81"/>
    <dbReference type="STRING" id="759272.G0SH81"/>
    <dbReference type="GeneID" id="18260943"/>
    <dbReference type="KEGG" id="cthr:CTHT_0069050"/>
    <dbReference type="eggNOG" id="KOG0067">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_2_1"/>
    <dbReference type="OMA" id="LPWCMGA"/>
    <dbReference type="OrthoDB" id="9991913at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF281">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE NAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="3">
        <location>
            <begin position="117"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="4">
        <location>
            <begin position="208"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS17570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="429" mass="46583" checksum="82FCF9CA5006D916" modified="2011-10-19" version="1">MAKPNNTPVPSELPVSPMTLQSHIASRASPSANGSFERNLALSAASKPKKPIVLHIGDPIKYNPGTYATFSQEFEVIRPSTPERERPEFIRALKERRWGDFSAIFRPFWGTGGEMGKWDAELIDLLPDSVKVFASAGAGFDWADTKLLGEKGIIYCNSGLAAAEAVADFAVTMIISTFRHLPWCMGAATFISSSPHSPAREEVFRACHTHATAASHNPRGHTLGLIGFGNIGQHIAAKMGNPAFGMHIAYHDLERKPAAVEAQLRAVFYPDLPSLLRVSDCVVLCTPASPDNTPLITASMLQHLRPGSRFVNVARGSLVDEEALADALEAGTISAAALDVHADEPRVNNRLVRMATQVYCHDTGHPRPGRVMLTCHNAGGTIETHIGFEELSMRNIMDVLRGGNGITPVNLKHFKPKPVICDDYKNELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
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    <name>G0SHG3_CHATD</name>
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        <recommendedName>
            <fullName evidence="4">Vps72/YL1 C-terminal domain-containing protein</fullName>
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    </protein>
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        <name evidence="5" type="ORF">CTHT_0069920</name>
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    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
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        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
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    </reference>
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        <text evidence="1">Belongs to the VPS72/YL1 family.</text>
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    </dbReference>
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    <dbReference type="OMA" id="PVISYWS"/>
    <dbReference type="OrthoDB" id="3942062at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046757">
        <property type="entry name" value="YL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 72 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275">
        <property type="entry name" value="YL-1 PROTEIN TRANSCRIPTION FACTOR-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05764">
        <property type="entry name" value="YL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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        </location>
    </feature>
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    </feature>
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    </feature>
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            <begin position="210"/>
            <end position="266"/>
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    </feature>
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            <begin position="72"/>
            <end position="87"/>
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    </feature>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
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    </evidence>
    <sequence length="776" mass="82109" checksum="DB9F57252C21F3C0" modified="2011-10-19" version="1">MASDDDDDKLTSLDDLSDLSSTNSSDDENDNKQSKDTGSEEPLQVEWLVTSRAKRSTAGNRMKSVLANEIPADSDSDLELLFAEDEKDTVFSLDEAQENTSDEQMDSSSDDEDQEDNGDELAGEKELEREARAQRMSQRKRKAQEAIPAKFRKKVRIEQPERPPRPKKKSERTSWLPSPADMPTRSSERQTTKLSKQLLHQKMLEDEMRRKKMLERMEKKAKMLESQKKRPMTQAERLAEAAIVEKKNAKSLNRWAELEKQREEERMKKIAALNSRKLSGPVITFWSGIQEIQEGQAKHIGNLVSMEEKAPRRKRPSVAAALAAKEAQEAPTPEQRPEAGEQPAVKAENADIPATPIEAPVVPPLASALAPPSASGPASAPVPGSAPAPGQAPTPSPPVPSLAPPVPAPAPTHTPMAPPPIPPPPDVRPGSSGVLVAPVLAPPAGVTAPMPGGKSNILAPPNTSQTPLPLQMPGAAAPVAAPATPASLAPPQATAPALTPLAPTPKPPATLPLPPLPSTSATAQPEAQPPSAKPADQPQVGAQAPGQEPGVATTTPGDPAVGTKFTRSCIILQGFDDTAIKDKQVQTRIIFGRTMNKLAKPEQPLCVITNRPAKYRDPKTGLPYANAYAYRQIQRALRGDFKFSALLGCYVGRCDYAAAGAPDWFVDPSPNAPHKAAAPTALATETPVAAEKGQEPMLVKIDEGEGDAKKGGEEGQQPELQGKSIVDEPRLVPGDLVGESGQQQGVGGAGPPGPGLAGPAPVAGQPVAAAAAISNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHL5</accession>
    <name>G0SHL5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mediator complex subunit 15 KIX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0070460</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Mol. Cell" volume="81" first="1781" last="1788.e4">
            <title>Mediator structure and conformation change.</title>
            <authorList>
                <person name="Zhang H."/>
                <person name="Chen D.H."/>
                <person name="Mattoo R.U.H."/>
                <person name="Bushnell D.A."/>
                <person name="Wang Y."/>
                <person name="Yuan C."/>
                <person name="Wang L."/>
                <person name="Wang C."/>
                <person name="Davis R.E."/>
                <person name="Nie Y."/>
                <person name="Kornberg R.D."/>
            </authorList>
            <dbReference type="PubMed" id="33571424"/>
            <dbReference type="DOI" id="10.1016/j.molcel.2021.01.022"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.58 ANGSTROMS)</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006697259.1"/>
    </dbReference>
    <dbReference type="PDB" id="7JMN">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.58 A"/>
        <property type="chains" value="O=1-1625"/>
    </dbReference>
    <dbReference type="EMDB" id="EMD-22397"/>
    <dbReference type="SMR" id="G0SHL5"/>
    <dbReference type="STRING" id="759272.G0SHL5"/>
    <dbReference type="GeneID" id="18261084"/>
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    <dbReference type="eggNOG" id="ENOG502S52Q">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003853_0_0_1"/>
    <dbReference type="OMA" id="GQLKQWA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1625" mass="175072" checksum="CE5B4177A69A9EA1" modified="2011-10-19" version="1">MAANIPQFPNGQMAMLQQQQQQAQQQAIAANQQYMNVFILNNLRGSGTNLPGTWQAQIPPQQLLSERFQKTHILYTNIMLASNGGDPQRCAVAALNLEKQIFQNAQDKASYDQAMAAKISEVMKRRESNGPALQNQVITDAQRQAQIQQQIQLAQAQQRQQQQLMLNRMAAQGLTQPPQPAFQPMQNPGQVPVIPQQMGINVAVPGMLPNAPSQPQLAMQMGQPRPGAIPVDLNQLSNQDRMRIHEEVMRRVNSTTENSKMQIRQLMQQRLTPAQISEANASGKDLVYLYFQNQVVQVFRATMLQAQQKAQQVAQVQQALLMQQRQGIQGAGMPGVPPQGQVNPALMNALGQQPAISDAPMLGPNLTNEPQMGLLAQQPGQMIVPTNPAAVPGRPVTAGPQLGAIPPQPTPGNPQAPNQTPRPGQLQQPFGMPQVNNPAAAAAAAAAAAAVQQPPQAQPGMRPPGPRTMPGQPGAITTVAGPQPTSQSPAMNTLNAPMRQPPVAMTQATTQPVNPANAPMAGATLNAQFNHQNNARPLSMQGNMNNQAMAGMGAAANMNANNNPMKEFMARLQEQQRATAAAGFQGPKPGQVIGMPGQFPGGPMNALNQPGMFNQNSKPNAMVPPTAQAAALQQQQQQANAADMANIYKIIQTPQGQNMMNNMDIHQMILQEINKHLGGRLPPNITKWAHLRQFLAAQPNALPSEIVQRIMSYQILQFKNFWKRASQPNAVGGIPQPVSNVPVSQFAGMNQPVAPPPGVQVPQSISQVSPQDIEGLRKNPKFANLTDDQLAEWIRKVKQQSFIKKAWEIHNNQSNAAQNQATNSSLIGQQKPGMTVPPTPTTAQPTSSVVQTAQSRPQGPQPTPTPQGPQGVQPQAAQPKPTPSPAANVTTAPPATTGMSAASVQAANIRPSMPQQQQQPAPQPQAPQPPPPQQQQQQQQQQQQQQQQQQQQVPQPPQNSRQAPMDPSPAMATKSLKRPSPDDSAEDTPAQQNITPMQRAPSQAAQVAPNAPNAASGEPPKLSPELQKLRNLASEAQLEVSKEHLQPILMTPADQQETREKIAQVKLKMNQIRSMGLLPKWYYLTNDDNRARQFFRGRFKVVKQFTDGEAMTQLRDTFTITKEELNQYDNLLGSMLRDMMMSRVNQQQAAMMNQQQQTQQQTTQPTPATLANQQAAALRQAQQRVAPPPPKPVQQPPAQQQQPHQPAQPAQQQFQPGVQPTPAPAPEYFGDQRLTAANLVLPPRKKPKVSGNQTSPSANQQLAAGSPQVQALSPVATRKPEPQVKPQAQIPQQQQQQQQQQQQQQQQQQPQAPPAPQFKCPEPGCTSLVAFPSEEALNAHRQEEHLKPAENPLAFMQEQMASVLALDAQGRAKASPKPSGQDVSTPVPTAPPMSASLSKQGQTPRLQAATPMSRNLSMQRQGSASGGKPGENMPTPGKSAGGKGKEGATPQQMEDVWPQGTIDPANLFANLGGTLDAGTATISGSIITDFAAYRSSTPKDTPESSSSSKDSGVSEPNSDINENANLEIDLFWSNIDDGLLMDINNISMDGAAGSMGGSSGNAGGLVDISQFVEDPWGVDSANFSLDDFGRELDKGFGFLDGTLGEGQQESGQGQGQGQPEVMVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G1DJA1</accession>
    <name>G1DJA1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Cytochrome c oxidase subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CTHT_m000310</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="19"/>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:11437"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="15">Binds a copper A center.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion inner membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the cytochrome c oxidase subunit 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="JN007486">
        <property type="protein sequence ID" value="AEI26009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004769782.1">
        <property type="nucleotide sequence ID" value="NC_015893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G1DJA1"/>
    <dbReference type="STRING" id="759272.G1DJA1"/>
    <dbReference type="GeneID" id="11030319"/>
    <dbReference type="KEGG" id="cthr:CTHT_m000310"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13912">
        <property type="entry name" value="CcO_II_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.90:FF:000004">
        <property type="entry name" value="Cytochrome c oxidase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045187">
        <property type="entry name" value="CcO_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002429">
        <property type="entry name" value="CcO_II-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034210">
        <property type="entry name" value="CcO_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001505">
        <property type="entry name" value="Copper_CuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011759">
        <property type="entry name" value="Cyt_c_oxidase_su2_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036257">
        <property type="entry name" value="Cyt_c_oxidase_su2_TM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22888:SF9">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22888">
        <property type="entry name" value="CYTOCHROME C OXIDASE, SUBUNIT II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00116">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02790">
        <property type="entry name" value="COX2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01166">
        <property type="entry name" value="CYCOXIDASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81464">
        <property type="entry name" value="Cytochrome c oxidase subunit II-like, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00078">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50857">
        <property type="entry name" value="COX2_CUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50999">
        <property type="entry name" value="COX2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0186">Copper</keyword>
    <keyword evidence="9 15" id="KW-0249">Electron transport</keyword>
    <keyword evidence="19" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 15 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15 19" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-0540">Nuclease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 15 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome oxidase subunit II transmembrane region profile" evidence="18">
        <location>
            <begin position="14"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome oxidase subunit II copper A binding" evidence="17">
        <location>
            <begin position="111"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AEI26009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="250" mass="28733" checksum="E8BDFE04A983FE69" modified="2011-10-19" version="1">MFILINWLNMNFDAPSPWGIYFQDSATPQMEGLVELHDNILYYLIIILFSVGWILLSIIRNYISTKSPISHKYLNHGTLIELVWTITPAVILILIAFPSFKLLYLMDEVSDPSMSIIAEGHQWYWSYSYPDFLNSNEEFIEFDSYIVPESDLEEGALRMLEVDNRVIVPELTHVRFIITAGDVIHSFSCNSLGIKCDAYPGRLNQVSVFINREGVFYGQCSEICGILHSSMPIVIESVSLEKFLTWLEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G0RY26</accession>
    <name>G0RY26_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0005160</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691054.1">
        <property type="nucleotide sequence ID" value="XM_006690991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RY26"/>
    <dbReference type="GeneID" id="18254554"/>
    <dbReference type="KEGG" id="cthr:CTHT_0005160"/>
    <dbReference type="eggNOG" id="ENOG502RA40">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_480578_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="567" mass="63075" checksum="E9BCC7879EA7E5E1" modified="2011-10-19" version="1">MWCPRKKTYTSQPSIHTIEEIELGLGDIGRGADFPLSRSRGGSHSSKRGLDITSPIAYSHLRASLGEVARQQHLENYRCKNDYYDEHPTYTMTEKPGQEKHHQGAKAVVAPSLDGKTNKEMSKAVENGKISVPIVDASLTFQDWSGSTDWPTGTVQGRDIHPTHTDGIPKPPAFHHNWTRPNLRAAQGYRDPSTLITAATYNGVPIGSRTRPIDFSKPKKQISPEKYGAECSNNDINSEKSYDGHHDESSGTQLQGTGEQPLHMPEQKKGEYDLTSSEEARIRDYFKHPQDFDEKYGLEVRHLVRKHLHNLEHMFEESEKQRERECSYAWLPPKPVEPDSVSIKAVSASSVRLSHSPTVCSSKAELVDLDSQSEEQSVNELSLKMAELDANDKGKHAATKNNAQSLSDSSSAYDDRKWNEKLDLYRASSVYDDDGMGGFGSRDNRYASTYGSGNYPGYNGNGYAAGPNPYFDGNNNPFFENGAGHSNVSYGTRNDNNLADNNGQGASGYMTWAYETYEMACCDDGSYESTYVNRGNGATEHTTQPPAQPYAQKAAQKVQGNYPWQWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYB4</accession>
    <name>G0RYB4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Myb-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0006090</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691142.1">
        <property type="nucleotide sequence ID" value="XM_006691079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYB4"/>
    <dbReference type="GeneID" id="18254647"/>
    <dbReference type="KEGG" id="cthr:CTHT_0006090"/>
    <dbReference type="HOGENOM" id="CLU_1094163_0_0_1"/>
    <dbReference type="OrthoDB" id="5353914at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054505">
        <property type="entry name" value="Myb_DNA-bind_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22980">
        <property type="entry name" value="Myb_DNA-bind_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like DNA-binding" evidence="3">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS23900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="254" mass="27289" checksum="78AAB3E87ED91167" modified="2011-10-19" version="1">MPALKDNIKDSKMPGATEEHLVNFAAVAEELNIVSKAAAAKRYERLLKAHGINPASPRKNAATKTEEEGEPSTPSKKRKRATARNTTASKEDDEAQASKTPTKRGKKAAKEETAVKEESSDVKDEQDIKEESDSDANVKKESSEGLSTPPSSSSSQPHPPRPPQPQTPNPGLLTTMATPATPPPTPPKDEDRIILGERRVPVPTSTPVSGSSPAPCSSNFDFSEHIGSLLLIWLANTTLNISFSIITVRIKVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYB6</accession>
    <name>G0RYB6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0006110</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691144.1">
        <property type="nucleotide sequence ID" value="XM_006691081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYB6"/>
    <dbReference type="GeneID" id="18254649"/>
    <dbReference type="KEGG" id="cthr:CTHT_0006110"/>
    <dbReference type="HOGENOM" id="CLU_2291368_0_0_1"/>
    <dbReference type="OrthoDB" id="4525115at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS23902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="101" mass="11643" checksum="F15661BCA4D51606" modified="2011-10-19" version="1">MPPKRLLHSWNAETHEDVLIALLDIMKPVKEDWAKVMENLREKGYTFSEGALVNPTVWDHDAHLTLLQAVMSENPPTADEWERILKRVEAKGYRYTPSAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYD1</accession>
    <name>G0RYD1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0006260</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691159.1">
        <property type="nucleotide sequence ID" value="XM_006691096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYD1"/>
    <dbReference type="STRING" id="759272.G0RYD1"/>
    <dbReference type="GeneID" id="18254664"/>
    <dbReference type="KEGG" id="cthr:CTHT_0006260"/>
    <dbReference type="eggNOG" id="KOG2543">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028223_2_0_1"/>
    <dbReference type="OMA" id="QLRRWHG"/>
    <dbReference type="OrthoDB" id="365981at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020796">
        <property type="entry name" value="ORC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047088">
        <property type="entry name" value="ORC5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048866">
        <property type="entry name" value="ORC5_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14630">
        <property type="entry name" value="ORC5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21639">
        <property type="entry name" value="ORC5_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="8">
        <location>
            <begin position="18"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="ORC5 lid" evidence="10">
        <location>
            <begin position="230"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 5 C-terminal" evidence="9">
        <location>
            <begin position="350"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="303"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS23917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="529" mass="57042" checksum="44577B3A835658D9" modified="2011-10-19" version="1">MNLFRLPDELIFSALCQQFPCRDPQIRALATLLHPSAAPCPNLVLHGTEATGKTAITSALLSKLSSSLDNQDEKEGPTLRYAIINSLECITARHLYETAVAKVAAALEWDLSSSGRCESVSQLTVELCKMLKYPSRPDGFRFVLVFDGIDRQREAPGTLLPGLARLSEIIPRLTTLFIVTTPPPSLHLHPPIPHIYFPPYSKPDYVTILSATKPPPPSPTTSPSDTADLWMRFIGAVYDSLAKAACRTLPALKHACETLWPRFTAPIAQGIYGAREFSKLLVAGRVLFQDENVLEPGVVSLPPAGSSKPSLPSNPNPSFITAGPLSPVKKPPQPSATLKGTTTADLATLLPPTARLLLLASYLASHNPSRYDITLFSTHYHGRKRRLGGPKLKSSTPGQRSKHRKISRKLLGAHAFVLERMLAIYAAVRSEWDPKFNLREGDEVVALTGDVDVGMALATLASLRLLVKVGGAGGGGSAAMGGIGLSGGGGLVPADVMDRGGKWRVNVGWEFVRRVGRSLGVEVEEWLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYR8</accession>
    <name>G0RYR8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0007660</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS24054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691296.1">
        <property type="nucleotide sequence ID" value="XM_006691233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYR8"/>
    <dbReference type="STRING" id="759272.G0RYR8"/>
    <dbReference type="GeneID" id="18254804"/>
    <dbReference type="KEGG" id="cthr:CTHT_0007660"/>
    <dbReference type="eggNOG" id="KOG1528">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033446_1_0_1"/>
    <dbReference type="OMA" id="EGCIFFA"/>
    <dbReference type="OrthoDB" id="411145at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01517">
        <property type="entry name" value="PAP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051090">
        <property type="entry name" value="Inositol_monoP_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200:SF2">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200">
        <property type="entry name" value="PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS24054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="364" mass="39721" checksum="85364D42F0F1EFFE" modified="2011-10-19" version="1">MDSPYRLELEVAIHAAQTAANISRMALSAAQTDAPSAAAFDLIKDDLSPVTVADFAIQAVLTRTLRNAFPEDGFVGEESADELRKNPKLLDRVVAIVRQCAGDSLFRDADDLCDVIDSCTTTKLSGPSPSRIWVFDPIDGTKTFMRGEQYAINIALLLEGKQMLSVVACPLLSVAATAPVLDSSIDPTGEGCIVFGVRGYGAYVRPLSGEWDEVQPRRLERHAEKVTSPEQLRNVTCWALLDSGVDVVHKGVAEQLAVPFPGCDLLGWVPRWVVMALGLANMTVWVYKTRDRYAKIWDHAGAMLLFEEVGGMITDVHGRQIDLTSGRKLQANFGFVAAPKHLHQLVLKAVHDTLKANGREELLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYZ8</accession>
    <name>G0RYZ8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyridoxamine 5'-phosphate oxidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0001150</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690668.1">
        <property type="nucleotide sequence ID" value="XM_006690605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYZ8"/>
    <dbReference type="STRING" id="759272.G0RYZ8"/>
    <dbReference type="GeneID" id="18254153"/>
    <dbReference type="KEGG" id="cthr:CTHT_0001150"/>
    <dbReference type="eggNOG" id="ENOG502S4PT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078856_0_0_1"/>
    <dbReference type="OMA" id="HPTIIMT"/>
    <dbReference type="OrthoDB" id="5300823at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052841">
        <property type="entry name" value="PMP_oxidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28040">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE YLR456W HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28040:SF1">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE YLR456W HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="2">
        <location>
            <begin position="8"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="214" mass="23228" checksum="AF3DC4439492696B" modified="2011-10-19" version="1">MRVTATLPSEVVQCLENARFLHLATCRDNVPHVSLMSYTYLPSSPYSRGPVIVMTTNPASKKILNLSENPNVSLLVHDWVSHRPTPASQARRLSSGNTSPTRGLPIQQPPSSLAALLFNLNASSISSISATINGTARVAPHGSEEERYYRDVHLANNTFDEGDGSSRFASGGEEEARVVVVTIRDGRISDWKGGVRDWVLVDESGMDAPRVNGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZ23</accession>
    <name>G0RZ23_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">propanoyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.176</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Propanoyl-CoA C-acyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0001440</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.1.176" evidence="2"/>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690693.1">
        <property type="nucleotide sequence ID" value="XM_006690630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZ23"/>
    <dbReference type="STRING" id="759272.G0RZ23"/>
    <dbReference type="GeneID" id="18254182"/>
    <dbReference type="KEGG" id="cthr:CTHT_0001440"/>
    <dbReference type="eggNOG" id="KOG1406">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035425_0_1_1"/>
    <dbReference type="OMA" id="PSLYAMM"/>
    <dbReference type="OrthoDB" id="542135at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00829">
        <property type="entry name" value="SCP-x_thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000016">
        <property type="entry name" value="Non-specific lipid-transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055140">
        <property type="entry name" value="Thiolase_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006102">
        <property type="entry name" value="PRK08256.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870:SF1">
        <property type="entry name" value="NON-SPECIFIC LIPID-TRANSFER PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22691">
        <property type="entry name" value="Thiolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="10">
        <location>
            <begin position="11"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="11">
        <location>
            <begin position="263"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS23451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="462" mass="49605" checksum="AC7945C996BCBBBE" modified="2011-10-19" version="1">MAPKQKRPAYVLGVGMTKFIKPRGQVDYTEMGYEAGIKALLDAHITYDEVEQGIACFCYGDSTSGQRVFYQFGMTQIPIYNVNNNCSTGSTGLFMARNMIASGAADCVMVVGFEKMMPGSLQSFWNDRESPLGTSFAVMAKTRGVAKAPGAAQLFGNAGREYMEKYGAKVEDFAEIARINHAHSVHNPYSQFQDVYTLEQVLKSPMIHEPLTKLQCCPTSDGAAAAIIVSEDFLNKRPELREQAVLIAGQSLATDSPALFSSSAIDLVGREMTTRAASIAMAEAGITAADVDVCELHDCFSANEMVLLDALGLAEPGKAHELVRAGGITYGGKVLVNPSGGLISKGHPLGATGIAQCAELVWHLRGWANNRAFDKRPTKIALQHNLGLGGAAVVTVYKRADGKEAKVLSNEEVGKRNGLGYNPAVEAKGITKEQAAKVRSKKWSPVSMVKTKELMQARGGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZ68</accession>
    <name>G0RZ68_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="7">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0001890</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="7"/>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690738.1">
        <property type="nucleotide sequence ID" value="XM_006690675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZ68"/>
    <dbReference type="STRING" id="759272.G0RZ68"/>
    <dbReference type="GeneID" id="18254227"/>
    <dbReference type="KEGG" id="cthr:CTHT_0001890"/>
    <dbReference type="eggNOG" id="KOG0351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001103_9_3_1"/>
    <dbReference type="OMA" id="HAFICKY"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF152">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="201"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS23496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="421" mass="49241" checksum="B8FA5C444E10E9C9" modified="2011-10-19" version="1">MQPLSLSGLLKTNTFLSYNRRLTSLKSYANVDARTLNSNTPPSERDYIYQDLATGHPRTRLLYVTPELCSSEHFRRQLRLVHEQRELARIAIDEAHCISEWGHDFRKDFKRLSWFREMFPDVPIMCLTATANEQVRRDILTTLGLDRTPERLKNFTMTAHRPNLHLEVRFTSDQANDRFDDFVTWLKGVYARRSQPERKAELDAVGERVQNVPGIIYTLSRDECEMLAAALRQEEIGARPFHAKLPKEVKEETLARWIANEPGYDIIVATTAFGMGIDKENVRFVVHWRLPKSFEGYYQEAGRAGRDGNASYCFLYYAREDRDRVCNMVMRDGGPNDTNREARMRSLSRLVEYCESTDTCRHAFICKYFGEEKVPECDYACDWHKDPQGLKRRMMAGLASEEWVSTQREEGRFDDYEYWSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZB1</accession>
    <name>G0RZB1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0002330</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690781.1">
        <property type="nucleotide sequence ID" value="XM_006690718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZB1"/>
    <dbReference type="STRING" id="759272.G0RZB1"/>
    <dbReference type="ESTHER" id="chatd-g0rzb1">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="18254271"/>
    <dbReference type="KEGG" id="cthr:CTHT_0002330"/>
    <dbReference type="eggNOG" id="KOG1516">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_10_3_1"/>
    <dbReference type="OMA" id="CRFWWDR"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="13"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS23539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="653" mass="72403" checksum="2B510DCB249F64FC" modified="2011-10-19" version="1">MAAQTPAGPQSRPYVVLPQGTYIGITVPQSYKYPKAFEAFRGIPYAQDTSGQNRFRPPQPLPKSSQTFDARFWGPVCPSGGVLRPNMSENCLNLNVYRPAGIVVDRKGFAADGKHPRLPVAVYIHGGAFNWGHGGERNMGSFISWNEQPMISVVFNYRIGALGFLPSNVTEREGLLNLGLRDQQMLLEWVQENIEAFGGDPNNVTIIGLSAGAHSIGHHIMHYARTKKPAPFHKAILESGATTARAVLYPNHPRHETQFREFLAAAGASHVPEAELFPYLRNLPLETIMRASNSVWNKYTASVTWPFQPVIDGPNPHAYSRHLPSARDLTIPVIPDLPIASWLAASHLRIPIITGYNTNEGTNFIPQHADTPADFRNFFKTLIPSLTEADLAELDRLYPDPVAHPATSPYVKVPKGFGRQWARLDAAYSHYAYICPVLQTAHFMTLAGVENVYVYRYAAVSGLGYANHGDEAAVVSHDVDAIGRWAGVVKIADEMCSRWGRFVVSETGDVNRGIKDLNWPKFVSPFSEKEGAGQLLVFGEGNNERAGGKSMGVPVQVRTLTELEKQACKFWWERVWLSEGMGVPRGGGGRRGYDYMVGAACRLRFYLLGTATRERMDGEESWDCGDRMRRLGFANTRRRNTATDMGLLGRSRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZH4</accession>
    <name>G0RZH4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione S-transferase kappa</fullName>
            <ecNumber evidence="4">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0002970</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GST superfamily. Kappa family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="4"/>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690844.1">
        <property type="nucleotide sequence ID" value="XM_006690781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZH4"/>
    <dbReference type="GeneID" id="18254335"/>
    <dbReference type="KEGG" id="cthr:CTHT_0002970"/>
    <dbReference type="eggNOG" id="ENOG502S5GX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069253_1_4_1"/>
    <dbReference type="OMA" id="ECTNSKG"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000096">
        <property type="entry name" value="Glutathione S-transferase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051924">
        <property type="entry name" value="GST_Kappa/NadH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014440">
        <property type="entry name" value="HCCAis_GSTk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943:SF2">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006386">
        <property type="entry name" value="HCCAis_GSTk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="6">
        <location>
            <begin position="6"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006386-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS23602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="224" mass="25163" checksum="08BA4F7E17B38BC6" modified="2011-10-19" version="1">MARPKITLYVDTVSPFAYQAYYILRNDPIFKNVDITYIPIFLGGLMHKCGNTAPIKIKNKDKWINIERLRWSRLFSIPMLESLPPDFPAPTLPVMRALTAVYASEQNDSAQPKFTRALDALFKAHWVDGQATHRPEELKKALAEIFGAEEADKIIKQSATPEVKQLLIQNTDRAFDEGAFGLPWLTCTNADGKTEGFWGVDHLGQAVVFLGLDKGTNNGWRAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZK5</accession>
    <name>G0RZK5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0003280</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690875.1">
        <property type="nucleotide sequence ID" value="XM_006690812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZK5"/>
    <dbReference type="STRING" id="759272.G0RZK5"/>
    <dbReference type="GeneID" id="18254366"/>
    <dbReference type="KEGG" id="cthr:CTHT_0003280"/>
    <dbReference type="eggNOG" id="KOG0800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_270734_0_0_1"/>
    <dbReference type="OMA" id="WPVINTE"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053238">
        <property type="entry name" value="RING-H2_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14155:SF627">
        <property type="entry name" value="OS06G0192800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14155">
        <property type="entry name" value="RING FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="862"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="280"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="343"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="405"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="470"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="687"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="936"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1141"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="29"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="155"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="216"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="292"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="352"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="470"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="484"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="512"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="526"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="587"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="622"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="708"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="718"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="778"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="965"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="986"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1000"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1010"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1148"/>
            <end position="1158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS23633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1201" mass="129611" checksum="054B9E8B080B9E47" modified="2011-10-19" version="1">MAAIESLEPYSLREPDHNPAPLAFPPLHQQPAPGSASGPGCPFFRGGQQHPGHLGPQNQQQQHLSLPPISAPGPFSPFRPSSHQLPQLLPHPAPFSSPGPQRHPIQTTTQPLAASSSSTANSSQGLFTPPPPPQQQQQQQQQQQQHQHQQHQHQQHQPQRQQAYRPLQQQPQGSQGQPQPQPQPQQQQQSQAQSFFQQSQQLLPLPQPTPPTLPHPHFHSQAHHYHHHSQSLSFNTGSTGNTSASFSPFSPIHPLNNSTPPGHLSQYDSVHLASISSWTSGARSATPWPEPANAHLHQHNAQHTQSTPGTQSTQSTQSTQGPQGTQGLQSLQFPAQYTQYTQYPQQPGQFGSGQTPSLNHRPSVSVSDPATDPTFSTQPPVTGSTAPGVPITSTAAAATIGSSVSHGEAGSLNRAGSSLSTLGSDSRGAVSTGGTSSQEGTAAVSAGPSLPGAAAVQPLLNPPAAQEFWSPTFSLQSPGFSHHTTTTTTTTTTTTTNNNNNNNNNNSSNTNHVPNSHQGYHSQLPPLVPAIFPNPPPSIPHPHQHQSQQQQQQTAWHHRPNQPLPTPSTHPGIGRSGPTDTPSPSNTAPTAQQAPSTQTTMNFQRGGHLPPPRDLSLPSLEAISTLNPPNSNTAGAASINNTATTSSQAAQPYHTVSHSRLDHGLHMSQPPPFRDMIRSAVEETTRALNTLGPRRSSVYQTLESPASPRRDSPHRQPDNSSGSQRTEGTFATSRSPMPTLFGSENAPSAPIPIPVPSSVSDRNRRFAAHPPTHIRDDFDSDDEEDDDDGRDSLMDEDEAVLRYIAGGPNALFPNWRGLPEDQLRTVQILRGQMSNKRVASRKALAMLESVPLETLPESERTCVICYNDFGQPTPEGHIEAPLRLPKCKHIFGDYCIKKWLEDSDSCPYCRDKLPSEPAIPQSYRAVHDLLRSAISRHRQTARQSESRRHASSETSQLHAADSQEHSTGQQRSGQQDNAAPRSSQTGERRLHPSEGPESRRRTRARHTHRSSLTASSTGTPRPPATTGTPGSQNSPPRERPTSILLNYYNQQYSLGPYQQLRPQPPSTTLATNLMSPTTSGNGAAPTPATINSPTRPVAAMSYEYQQDIHWSALRDPPYTHGPSYMPPLNPNSFVAWNGTPSMPPITQPHPSTIPTGVTSGPDRNVAGGRRDGSSASSSTDEMEVDSWESQESAAAMGARNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZW5</accession>
    <name>G0RZW5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0007870</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691317.1">
        <property type="nucleotide sequence ID" value="XM_006691254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZW5"/>
    <dbReference type="GeneID" id="18254825"/>
    <dbReference type="KEGG" id="cthr:CTHT_0007870"/>
    <dbReference type="eggNOG" id="ENOG502SFYZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_483955_0_0_1"/>
    <dbReference type="OrthoDB" id="5292518at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861">
        <property type="entry name" value="GLYCOPROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861:SF4">
        <property type="entry name" value="SH3 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G13610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="459"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="563" mass="60484" checksum="FB9A21E86EA4586E" modified="2011-10-19" version="1">MRRNNKLAISTSENFKATSVLLGYPHAAYGFKLVGNAHAPFRLNSVDPDFRSPGNLPASITGPFYHLETARYRYAQFLVLVAKTEAQARAQVTPPPVLRRDDDDDEKARLELTCPVEHHLCATVTPMQCPTGYYLCPSTLNYGCCKTGMACAQFACYSTDPVTSTFLETITTTVDDKLVTTVITSLSISTPTAPTLFIEQPNVAAKFIPTAVTKVPAKTPSSQSDSSDSNGGLSPGAIGGIIAGVVALLIVVVIAAFLVILRLRHVQQAYESSSRTRTEDSASRGHRGAVPQSYTSPPNPPPMQEYHRTSGIDDDMSLSVEPSTGLYRDLHSSSMPISGLGHSRGRSDSSITPAPSPYNWAGASELGADSPTNNPGYAYYLDSQQQAQASYSPHHRRMHSNSITTDNSSPRVPSTGYQYPTYPRHWRQQSNTSEFSSDGSEHGGVHAPLMMPGHRRHPSSFSQSQSQGQGFVYGPRGYQPVVVADEADSTPVYELEGEGFGRVQQQVRADEGLVGIAPGGGVLLPGEGTVAATGAQQGHENGEDASGEQRQQQQHGRSKKEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0F6</accession>
    <name>G0S0F6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0009850</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TLS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691508.1">
        <property type="nucleotide sequence ID" value="XM_006691445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0F6"/>
    <dbReference type="GeneID" id="18255023"/>
    <dbReference type="KEGG" id="cthr:CTHT_0009850"/>
    <dbReference type="eggNOG" id="ENOG502S5M8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047429_1_0_1"/>
    <dbReference type="OMA" id="MCDRFTA"/>
    <dbReference type="OrthoDB" id="5627at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010756">
        <property type="entry name" value="Tls1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13486:SF2">
        <property type="entry name" value="SPLICING FACTOR C9ORF78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13486">
        <property type="entry name" value="TELOMERE LENGTH AND SILENCING PROTEIN 1 TLS1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07052">
        <property type="entry name" value="Hep_59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="185"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="253"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="373"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="198"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="253"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="284"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="301"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="416"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS23317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="437" mass="47170" checksum="43E303235EA4301A" modified="2011-10-19" version="1">MATADSESNPAPQVVFRTKKKAKPYRQHTATTVENLESSFATANASELTKEEASPAATSAPAASGIESTSDVPAAATSTAQDKKSSEEDEEDGLSVTELLKLRNARKHKLAGVGFRATDEKPSATGEEQNNMDGKGLVVRAAAGLAGSEVEQLIGGITKRFAPQTGFVGDLVNRHMEEYVESELAKRKRLAAEASARQQQQEQEQEQQQQQQERATRSSLLGGSQLLQAADPASGQGDAQRVLHGKLFEIDLGDEARARNIEMTERARRRLQGLADDEMQNDGSGSGSGSGSAGTGGGLSKKPRLGKGPRNRRGSDDIQRDQMVEAFLSENKLDVYDIPSQDTHMGPHSGDEDEGAADDRIAEEFRREFMEAMAQRHRRRRPAQNAAKPGAKGRAAANEPILRGPKLGGSRNARAAMRDLLLKEQAQKQAQKPLGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0P9</accession>
    <name>G0S0P9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Isocitrate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0010800</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Can also use Mn(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691601.1">
        <property type="nucleotide sequence ID" value="XM_006691538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0P9"/>
    <dbReference type="STRING" id="759272.G0S0P9"/>
    <dbReference type="GeneID" id="18255118"/>
    <dbReference type="KEGG" id="cthr:CTHT_0010800"/>
    <dbReference type="eggNOG" id="KOG1260">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019214_2_2_1"/>
    <dbReference type="OMA" id="TVPHADF"/>
    <dbReference type="OrthoDB" id="4078635at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019629">
        <property type="term" value="P:propionate catabolic process, 2-methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.850:FF:000001">
        <property type="entry name" value="Isocitrate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01346">
        <property type="entry name" value="isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="ISOCITRATE LYASE/MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631:SF13">
        <property type="entry name" value="MITOCHONDRIAL 2-METHYLISOCITRATE LYASE ICL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001362">
        <property type="entry name" value="Isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="123"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="233"/>
            <end position="234"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="451"/>
            <end position="455"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="486"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS22609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="566" mass="62674" checksum="BC34E28A34D5350D" modified="2011-10-19" version="1">MASLPPVEPPISTSFPSEAYQLLPEQQKAGAAEDALMQEQIKQVEAWWASPRFAGIKRDWTAADVVSKRGSLQQSYPSSVMARKLWNLIQERMAAGQPIHTLGAIDPVQMTQQAPHQEVLYISGWACSSLLTTTHEVSPDFGDYPYNTVPNQVQRLFKAQSMHDRKHWFLRSKMTPEERAKTPYIDYFRPIVADGDTGHGGLTAVMKLAKLFAESGAAAVHFEDQMHGGKKCGHLAGKVLVPTSEHINRLKAVRFQWDVMGTENLVIARTDSESGKLLSSSIDVRDHEFILGVADPSVRSIAETLAEMEAKGASGAEIDAYEAQWVKSTKLVTFDEAAVAHFERNGVPQAKIDEYLAKVRADRDMGITARRALADAVTPGNPVYWSWDVPRTREGFYHFKNGMAAATKRALAFAPYADMLWVETGDPNVQVCRDLGRAVRDKFPGKPLVYNLSPSFNWMAHGFTEETLKSFVWDIAKEGFVLQLVSLAGLHSTATISSELARKFKEEGMKAYVDLVQKREKELGVDVLTHQKWSGANYVDAVLGHIQSGSSGSKSMGEGNTENQFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0Q0</accession>
    <name>G0S0Q0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0010810</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>oxaloacetate + acetyl-CoA + H2O = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>propanoyl-CoA + oxaloacetate + H2O = (2S,3S)-2-methylcitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23780"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:58853"/>
            <dbReference type="EC" id="2.3.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691602.1">
        <property type="nucleotide sequence ID" value="XM_006691539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0Q0"/>
    <dbReference type="STRING" id="759272.G0S0Q0"/>
    <dbReference type="GeneID" id="18255119"/>
    <dbReference type="KEGG" id="cthr:CTHT_0010810"/>
    <dbReference type="eggNOG" id="KOG2617">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022049_2_1_1"/>
    <dbReference type="OMA" id="NEAAMDM"/>
    <dbReference type="OrthoDB" id="8017587at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050440">
        <property type="term" value="F:2-methylcitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006101">
        <property type="term" value="P:citrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.580.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010109">
        <property type="entry name" value="Citrate_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01793">
        <property type="entry name" value="cit_synth_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007128">
        <property type="entry name" value="PRK09569.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF15">
        <property type="entry name" value="CITRATE SYNTHASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="active site" evidence="9">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR610109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS22610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="473" mass="52335" checksum="F11A46526FFD2867" modified="2011-10-19" version="1">MASSIRTTRALGGALRPVVASARAAGRRTYATAELDLKTTLKEIIPEKRELLKKVKAHSDKVIGELKVENTIGGMRGLKCMVWEGSVLDANEGIRFHGRTIKDCQKELPKGKTGTEMLPEAMFWLLLTGKVPSVNQVRQFSRELAEQAQLPEFVNKMIDNFPKDLHPMTQFAIAVSALNHTSKFAKAYEKGLSKADYWEPTFDDCISLLAKLPTIAAKIYHNTYKGGGALPGEVDLEQDWSYNFAAMLGKAGKENEDFQDLLRLYLALHGDHEGGNVSAHTTHLVGSALSDPFLSYSAGLQGLAGPLHGLAAQEVLRWILQMKEAIPENYTDEDIRNYLWQTLNSGRVVPGYGHAVLRKPDPRFEALMDYAASRPRIAADPVFQLVLRNSKIAPEVLKEHGKTKNPYPNVDSSSGVLFHHYGFTETLYYTATFGVSRGLGPLAQLIWDRALGLPIERPKSINLQGILDLVEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0R1</accession>
    <name>G0S0R1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine cleavage system P protein</fullName>
            <ecNumber evidence="7">1.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0010930</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 7">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GcvP family.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="7"/>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691613.1">
        <property type="nucleotide sequence ID" value="XM_006691550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0R1"/>
    <dbReference type="STRING" id="759272.G0S0R1"/>
    <dbReference type="GeneID" id="18255131"/>
    <dbReference type="KEGG" id="cthr:CTHT_0010930"/>
    <dbReference type="eggNOG" id="KOG2040">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004620_3_1_1"/>
    <dbReference type="OMA" id="RNLICTC"/>
    <dbReference type="OrthoDB" id="6537869at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016594">
        <property type="term" value="F:glycine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000005">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000007">
        <property type="entry name" value="glycine dehydrogenase (Decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000007">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049316">
        <property type="entry name" value="GDC-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049315">
        <property type="entry name" value="GDC-P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773:SF1">
        <property type="entry name" value="GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="GLYCINE DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21478">
        <property type="entry name" value="GcvP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="8">
        <location>
            <begin position="82"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="8">
        <location>
            <begin position="736"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="894"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS22621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1079" mass="119616" checksum="F6F60C663807F60C" modified="2011-10-19" version="1">MASRQIGRLGPKLGASALVVRGTSPLNLPLTLRAAAVTVNATTTRCYAKAPKPRPSTEPKQPEGIRLAMRARLFRSHEKFVDRHIGPNDENIQEMLKTLDPPVESLDEFVKQVIPADILTQRELFHDHHNYYSAQKYGVKEGLEEYEVQDLAKNMAWRNGILGKNMIGMGYYEARTPEVIKRNVFENPAWYTSYTPYQPEISQGRLESLLNFQTMVSDLTSLPVANASLLDEGTAAAEALTMSLNTLPTTRAKRPGRTYVVDENVHPQTINVLRSRAEGFGVNVVLKDLSKGDYSDIEALGEDLVGVLVQYPDTYGNVSDYKVLAEVVHKQGALLAAATDLLALTLLTPPGEWGADIALGNSQRFGIPLGFGGPHAAFFAVQEKYKRKMPGRLVGVSKDRTGRRALRLALQTREQHIRREKATSNVCTAQALLANMSAFYAIYHGPEGLKRIAEKCNLGARVLQAAAKHFGLVPADAPPVAFDTLAIKMKDTDASMKLNLICSKRRINARVAEGNLWCISVDEATRELDLLRVIQSFDEFVNGCPENDREANSTQCHQLLTRFIAEEKAKPTSVDRLSPGFKRQSPYLTHPVFNLYHSETELTRYIYHLQSKDLSLVHSMIPLGSCTMKLNGATEMSLISHDHWLRVHPYTFFSYTHGYDGLITGLKNQLKIITGMDGVSLQPNSGAQGEFAGLRTIRKFHESRGEGHRDICLIPVSAHGTNPASAAMAGMRVVPIKCDTKTGNLDLADLEAKCEKHADELAAIMITYPSTYGVFEPNIKKVCEIVHKYGGQVYMDGANMNAQIGLCSPGEIGADVCHLNLHKTFCIPHGGGGPGVGPICVKSHLIKHLPARKPAYVKDTTNWPVASAPHGSAAILPIPWAYNTLMGGDGLKKATQVTLLNANYMLSRLKPHYSILYTNEHGRCAHEFILDARPFQESAGIEAIDIAKRLQDYGFHAPTMSWPVPGTLMIEPTESESKEELDRFCDALISIREEIREIEEGKQPRDRNVLKLAPHPMQDLIDGDGEGKWDRPYSREKAAYPLPWLREKKFWPSVARLDDTYGDLNLFCTCPPVQDTTQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0Z8</accession>
    <name>G0S0Z8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0011820</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691700.1">
        <property type="nucleotide sequence ID" value="XM_006691637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0Z8"/>
    <dbReference type="GeneID" id="18255220"/>
    <dbReference type="KEGG" id="cthr:CTHT_0011820"/>
    <dbReference type="eggNOG" id="ENOG502QSKG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_2_2_1"/>
    <dbReference type="OMA" id="GWLETHE"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="25892" checksum="76562C8620ED6674" modified="2011-10-19" version="1">MDYHHAVVDMMLGGKLHLTPLDFNKVKKVLDVGTGTGAWAIDFADAHPDVEVIGTDITPIQPTFVPPNLRFEIDDANLDWTFRDNTFDYIHIRFLVGCIADWYKLFREAFRTLKPGGWLETHEPTLRWVGDRPIDPKSATGQFHQIFWEAGKKFGRTFRVFEEEIQKKAMEAAGFVNIMVTDIRCPIGSWPEDPEKKELGTVTQVAFLGDLDACGLFTAMYFGSLMVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0S145</accession>
    <name>G0S145_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LYR family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0012300</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691747.1">
        <property type="nucleotide sequence ID" value="XM_006691684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S145"/>
    <dbReference type="STRING" id="759272.G0S145"/>
    <dbReference type="GeneID" id="18255268"/>
    <dbReference type="KEGG" id="cthr:CTHT_0012300"/>
    <dbReference type="eggNOG" id="ENOG502S36A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021381_0_0_1"/>
    <dbReference type="OMA" id="EYAWRRT"/>
    <dbReference type="OrthoDB" id="275715at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="424"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="526"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="578"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="615" mass="64932" checksum="2A0FC4207A6349E7" modified="2011-10-19" version="1">MAPPQFRTATQTRRGARSGFVEQDDFEGLPVRQWRQEWVTYTPPVPQEVTQQSDRWAVELPFGMPRESHLLPPHSQELLRAARSGRLYKRPAPEEEDVDVEVDTIKGEKKDWETPNEGFTFKAWKQVPRNAEAADISYLAKRPKNIITLAAKVEPAQPTGPTITRAIVRRIDAAGNPYEQTITLTEGQKVDGEIISTTVVPAPTTQPEIVPQQTTPARRRPPPPKRKAKGVGRGRKKGKLPLPMHATRSQNAAAAGADAVKTEDNGVEGVKVEDAEDSANPDSEMADVSGVPSDEEEGEEDEEVDEEGGDEEGGETPNVGSTNGDVPSQEPEDTEMSDVPQQPSTEEASQPPTSEGEPPVQKVVRFQTPSIGTKLEGSPLKNVMVASPTEPAAPSNDSIPPSVAPPSPPSDQAMEVDQPDNDKTAPTATTITETPEPQIKLEQIPSEPLSQPPAEQPALTTQTPSQDAAAATESEEPPSSASANPADPLKPPASPALLPTVTNDNEDDGLNLLDSLERELNKQEEAANAAKVQNQAAYAGGGGGGVGAGNPGAGGAEQAAEEEEVDTLAVATEEGKGKVAVGDAGAGSEADKGGEEKQEKATEESAGGSYAGGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1J3</accession>
    <name>G0S1J3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Replication factor C subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0013800</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the activator 1 large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691895.1">
        <property type="nucleotide sequence ID" value="XM_006691832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1J3"/>
    <dbReference type="STRING" id="759272.G0S1J3"/>
    <dbReference type="GeneID" id="18255418"/>
    <dbReference type="KEGG" id="cthr:CTHT_0013800"/>
    <dbReference type="eggNOG" id="KOG1968">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003574_1_1_1"/>
    <dbReference type="OMA" id="LICNERN"/>
    <dbReference type="OrthoDB" id="446168at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17752">
        <property type="entry name" value="BRCT_RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000021">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000005">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000001">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000395">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013725">
        <property type="entry name" value="DNA_replication_fac_RFC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012178">
        <property type="entry name" value="RFC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF6">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25361">
        <property type="entry name" value="AAA_lid_RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08519">
        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036578">
        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="12">
        <location>
            <begin position="299"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="383"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="963"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="238"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="388"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="963"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="994"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1027"/>
            <end position="1041"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR036578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS22903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1041" mass="114863" checksum="007B03361EE322BC" modified="2011-10-19" version="1">MPDIRSFFAPKGSAPPKPAKPAAKKEEEKKARAKGRKVIEDSDDDIEDPPVDIKGVETTAAKYFSSSKAKSEPTSAQGTPKKSKAPPAAGSEVRLSPRTKTTKVSPEPKPTKNGTKKPVTAYKKHEQYDDDAFLDDDDDAGDDIFAAAVKKRKNDDYVEDDSDDEVLPKPKRVASKATKAIKTELDEDVKQTPNKAAQTVPAPSRKRKSPTSDSEFDDDEDVKPAKKAAPAKPRAPRAKKEDEPEADDIKAILDNVPLVQAPDAPPKDESQKFDWRKKFAGGGNAGPPPNPGAIEIPEGAENCLLGKTFVFTGMLKTISREDAQALVKRYGGKVTTAPSSKTDFVVLGDDAGPSKLRKIKEHNLKTINEEGLFYLIKTLPAHGGTGKGAEKAKQKQEKEEQKAREEALRMEQEEKARQEEAEKEAQKAAAARGVAPPPAAPAPVLSQLWTTKYAPTQLNQICGNKQNVEKIQSWLRNWPKARKWNFQKRGADGMGGYRAIIISGPPGIGKTTAAHLAAKLEGYDVIESNASDTRNKKLVEEGVTDILNNTSLLGYFAGDGKKVDATKKRIVLIMDEVDGMSAGDRGGVGALAKLCRKTEVPMILICNDRRLPKMKPFDHVAFDIKFQRPTVDQIRSRMMTICHREGLKMSPPVLNALIEGSGKDIRQIINMLATAKLDQTTMDFDQTKAMTKAWEKHVILKPWDICQKLIAGGMFSPASNATLNDKIELYFNDHEFSFLMIQENYLRSRPAALNGRNFANPREENLKYLELVDLAAESISDGDLVDCMIHGPQQHWSLMPTHAVFSTVRPASFIAGSLGGQTTFTTWLGNNSKYGKLSRFVREIHSHMRLRSSGDHNEIRQEYMPVLWQRLVKRLEVEGREAVDEVIELMDSYYLTRDDFDSIKELAVGPCAEEYVNIETQTKATFTRVYNANPHPIPFMKASSVTAPKKLSRDIPDLEEAIEEEDENDVLEPAEAEAADEEEELDLNKDKYIKMPKAKKPAGKKASKAAKAATDDEDDGEDDAPKKGKGKGKGSGRSKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1Y2</accession>
    <name>G0S1Y2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Potassium channel tetramerisation-type BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0015260</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS23042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692034.1">
        <property type="nucleotide sequence ID" value="XM_006691971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1Y2"/>
    <dbReference type="STRING" id="759272.G0S1Y2"/>
    <dbReference type="GeneID" id="18255564"/>
    <dbReference type="KEGG" id="cthr:CTHT_0015260"/>
    <dbReference type="eggNOG" id="ENOG502QRM9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017395_0_1_1"/>
    <dbReference type="OMA" id="PHEKVFP"/>
    <dbReference type="OrthoDB" id="2414723at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31758">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN YLR108C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31758:SF2">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN YLR108C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Potassium channel tetramerisation-type BTB" evidence="2">
        <location>
            <begin position="43"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="539" mass="60236" checksum="5BA9BA4E265D7F47" modified="2011-10-19" version="1">MANPTSTDHHPQGLDDQSTEHHSVEAMITRIPKILPHERVFPIQIGSELFKLSGASISSDAPSYFSQYFQCQIKEAEEKGEDLNIAIKTLYIDRDPVTFRDIALHLQGYHVRPRDSTHFVRLFADAQFYSLPKLISQLYEEPIFTTIGDREFQIPRELFSEHGNSPNFFSLGFAAFFSRPDDLFPGLDREGLLRPPSILPPSVPGRSAETFAEILHLLRGYPVEIRSEAHRAALLSDCRYFNFKALEQRLIPHEISYNLARHRNEIVLRLRDILKSGIGIAREPTPTDPAAAWVSYRRPYVDKDDYELVLEIGGESTRLVQFTYGSVQDAGINGTESASKFYPAASQKVLFARAEFVGETKARVAKLFEVLATKLGLNVTTQPLGLLMNQGGASSTPPTPGNTPISDDLVKVVIGPEAGVTLDGREWVIPFEEGEDEDEVEDDEVDTLFGGEGPRKRRKVEEGSGWPLALPSPMAGFVGETHGGWRGAQEWLVKTGQWRLRIQGVRNGKAPVECCLMAVKLDAFSSERERNVKRKFLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2024-01-24" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>G0S231</accession>
    <name>G0S231_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0015800</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS23091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692083.1">
        <property type="nucleotide sequence ID" value="XM_006692020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S231"/>
    <dbReference type="STRING" id="759272.G0S231"/>
    <dbReference type="GeneID" id="18255618"/>
    <dbReference type="KEGG" id="cthr:CTHT_0015800"/>
    <dbReference type="eggNOG" id="ENOG502T0FS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122522_0_0_1"/>
    <dbReference type="OMA" id="TSDYCED"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408764" evidence="1">
        <location>
            <begin position="17"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="166" mass="17394" checksum="8FAF2598913BA062" modified="2011-10-19" version="1">MKLIAALLSLIALASADPAFIRPFGPCYPNVCNIAVSMNRLGVPASKVRSSHCASFLRTTVTPAATTVTETVTVTFDDESPTTTPVSSSKVSSAAPVTITPTSIPNYARACLKAKEYATACSCFGVTGTVTTVPTPTVTVTSTLMVFDGKDDDDGDDWDSEEECEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G0S250</accession>
    <name>G0S250_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WLM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0015990</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS23110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692102.1">
        <property type="nucleotide sequence ID" value="XM_006692039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S250"/>
    <dbReference type="STRING" id="759272.G0S250"/>
    <dbReference type="GeneID" id="18255637"/>
    <dbReference type="KEGG" id="cthr:CTHT_0015990"/>
    <dbReference type="eggNOG" id="KOG4842">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056790_0_0_1"/>
    <dbReference type="OMA" id="QRRMAYK"/>
    <dbReference type="OrthoDB" id="49605at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47795:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47795">
        <property type="entry name" value="UBIQUITIN AND WLM DOMAIN-CONTAINING METALLOPROTEASE SPCC1442.07C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WLM" evidence="2">
        <location>
            <begin position="168"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="387" mass="42802" checksum="8455FB434F575A5A" modified="2011-10-19" version="1">MGDLSSEAEVDNNPIRQHAQEILDDTSIEIVIKFPPAQHTQTWNFSPSDTFAHLIQALSLEFPSYDWSKAKALPEKKPQPQGSGGVKPKAVYTPSADGPLSLSVLHGATLRFLAPQTSDLETLQKQQHSSTTQQARRILARAHQLRNAARPLSRSSGPRIATLSSPSGPSLSEEYTFQTLRPLSHLPNSHTSLSILEKLKNDPGIRHAMSHFRLRVQLLTEMDPLTYTSVSRSGDSVTRILGLNRNQGEVIELRLRLESTMQTSGGFARRLRGRLRRGINWGRGKGRVVGDGEGGEEFAPARDGEDETEEEGMVQDHGGWYGGTYVLGGGESGSSGTGGRQDVSPERMRALVAAAAELRMRKEREARERLEREERKKREEEGEKRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0S292</accession>
    <name>G0S292_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mediator of RNA polymerase II transcription subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MED9</name>
        <name evidence="10" type="ORF">CTHT_0016410</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Mol. Cell" volume="81" first="1781" last="1788.e4">
            <title>Mediator structure and conformation change.</title>
            <authorList>
                <person name="Zhang H."/>
                <person name="Chen D.H."/>
                <person name="Mattoo R.U.H."/>
                <person name="Bushnell D.A."/>
                <person name="Wang Y."/>
                <person name="Yuan C."/>
                <person name="Wang L."/>
                <person name="Wang C."/>
                <person name="Davis R.E."/>
                <person name="Nie Y."/>
                <person name="Kornberg R.D."/>
            </authorList>
            <dbReference type="PubMed" id="33571424"/>
            <dbReference type="DOI" id="10.1016/j.molcel.2021.01.022"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (4.20 ANGSTROMS)</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Mediator complex subunit 9 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692144.1">
        <property type="nucleotide sequence ID" value="XM_006692081.1"/>
    </dbReference>
    <dbReference type="PDB" id="6XP5">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.20 A"/>
        <property type="chains" value="I=1-179"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S292"/>
    <dbReference type="EMDB" id="EMD-22284"/>
    <dbReference type="SMR" id="G0S292"/>
    <dbReference type="STRING" id="759272.G0S292"/>
    <dbReference type="GeneID" id="18255679"/>
    <dbReference type="KEGG" id="cthr:CTHT_0016410"/>
    <dbReference type="eggNOG" id="ENOG502SW8C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097220_2_0_1"/>
    <dbReference type="OMA" id="IRIQKAH"/>
    <dbReference type="OrthoDB" id="5414694at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011425">
        <property type="entry name" value="Med9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07544">
        <property type="entry name" value="Med9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="12" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4 7" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="27"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="117"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS22125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="6XP5"/>
        </source>
    </evidence>
    <sequence length="179" mass="18305" checksum="33C36A32AB7DFC6F" modified="2011-10-19" version="1">MTAPLPEGLTPDAVDTLTELSAIIKKLRAAQQQQAANPSSQAAAGGPGTTGAPGSQPSSSGPNATAAGGAIGTTSLPSSATTGPTPSNALHSVKELPATTDPIKHKLQRARAAVRLLGDMSRTMAQQEAELARLEERRRKQAAMLAKAQEEGARLSKGFGEVGETPVVLVETGDKMAME</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2A8</accession>
    <name>G0S2A8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hydrolase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0016580</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692160.1">
        <property type="nucleotide sequence ID" value="XM_006692097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2A8"/>
    <dbReference type="GeneID" id="18255696"/>
    <dbReference type="KEGG" id="cthr:CTHT_0016580"/>
    <dbReference type="eggNOG" id="ENOG502QPU8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009024_0_1_1"/>
    <dbReference type="OMA" id="PSNGWIG"/>
    <dbReference type="OrthoDB" id="9971853at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050295">
        <property type="term" value="F:steryl-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904462">
        <property type="term" value="P:ergosteryl 3-beta-D-glucoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000131">
        <property type="entry name" value="Glycoside hydrolase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000174">
        <property type="entry name" value="YIR007W-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041036">
        <property type="entry name" value="GH5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052066">
        <property type="entry name" value="Glycosphingolipid_Hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308:SF5">
        <property type="entry name" value="ERGOSTERYL-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18564">
        <property type="entry name" value="Glyco_hydro_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="5">
        <location>
            <begin position="70"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5 C-terminal" evidence="6">
        <location>
            <begin position="637"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="571"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="598"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS22141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="760" mass="86263" checksum="50FB34483C81B7F7" modified="2011-10-19" version="1">MTSFRLIIEDGKFRDTKGRQVILRGINVAGDCKYPSKPHTPSHVPDNFFDGDNVKFSGRPFPKEEAHLHFSRLKRCGYNTIRYLFTWEAIEAAGPGKYDEEWIQHTIEVLRIAKDYGFYIFMDPHQDVWSRFSGGSGAPMWTLYAAGLNPQSFAATEAAIVHNTYPEPDNFPKMIWSTNYYRLATATMFTLFFAGRDFAPKCIIDGVNIQDYLQDHFLRAVGHLAKRIHEAEDLENDVVIGWETLNEPNKGMIGYQDISVIPKEQALKKGTCPTIWQTILTGSGRAVEVETWDMGGLGPYKVGKTLVDPHGEVAWLPAGYDDSRYGWKRDPGWKLGECLWAQHGVWDPESDTLLKKDYFSKDPKNGQTIDYPYFTNTWFMDLYRKYRDVVRSYHKDAIIFLQGPTMELPPLIKGTPDGDDPRLVYAPHWYDGITLMTKKWNRSWNVDVIGVLRGRYWHPAFAIKLGETAIRNCFRDQHAAMRQEGLDRMGNHPCVMTEFGIPYDMDDKYAYKTGDYSSQSAAMDANHFAVEGAGLEGYTLWVYHTHNDHERGDQWNGEDLSIYSVDDKLLPLDPRPRSPEANGTILSTKKGLDDDASVTPSNLKRSITNPSISSESTSRQPELTAAAGYRAAEAYVRPAPIVVAGDIIRYGFDLSQCLFTLTIKAPKVADLDSPTIVFLPEYHFPKDSCSVEVTSGKWEISSDEEETVLIQRLRWWHGEGEQTLRISGVVRKHNISGEEADEAGYYEQCNQGAWSSCNIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2E0</accession>
    <name>G0S2E0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U3 small nucleolar RNA-associated protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0016900</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="15 16 17" key="2">
        <citation type="journal article" date="2019" name="Mol. Cell" volume="75" first="1256" last="1269.e7">
            <title>Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration.</title>
            <authorList>
                <person name="Cheng J."/>
                <person name="Bassler J."/>
                <person name="Fischer P."/>
                <person name="Lau B."/>
                <person name="Kellner N."/>
                <person name="Kunze R."/>
                <person name="Griesel S."/>
                <person name="Kallas M."/>
                <person name="Berninghausen O."/>
                <person name="Strauss D."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="31378463"/>
            <dbReference type="DOI" id="10.1016/j.molcel.2019.06.032"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (4.00 ANGSTROMS)</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the NRAP family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692192.1">
        <property type="nucleotide sequence ID" value="XM_006692129.1"/>
    </dbReference>
    <dbReference type="PDB" id="6RXV">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.00 A"/>
        <property type="chains" value="UV=1-1171"/>
    </dbReference>
    <dbReference type="PDB" id="6RXX">
        <property type="method" value="EM"/>
        <property type="resolution" value="7.10 A"/>
        <property type="chains" value="UV=1-1171"/>
    </dbReference>
    <dbReference type="PDB" id="6RXY">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.70 A"/>
        <property type="chains" value="UV=1-1171"/>
    </dbReference>
    <dbReference type="PDB" id="6RXZ">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.40 A"/>
        <property type="chains" value="UV=1-1171"/>
    </dbReference>
    <dbReference type="PDBsum" id="6RXV"/>
    <dbReference type="PDBsum" id="6RXX"/>
    <dbReference type="PDBsum" id="6RXY"/>
    <dbReference type="PDBsum" id="6RXZ"/>
    <dbReference type="AlphaFoldDB" id="G0S2E0"/>
    <dbReference type="EMDB" id="EMD-10053"/>
    <dbReference type="EMDB" id="EMD-10054"/>
    <dbReference type="EMDB" id="EMD-10055"/>
    <dbReference type="EMDB" id="EMD-10056"/>
    <dbReference type="SMR" id="G0S2E0"/>
    <dbReference type="STRING" id="759272.G0S2E0"/>
    <dbReference type="GeneID" id="18255728"/>
    <dbReference type="KEGG" id="cthr:CTHT_0016900"/>
    <dbReference type="eggNOG" id="KOG2054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003502_1_0_1"/>
    <dbReference type="OMA" id="DERAHIP"/>
    <dbReference type="OrthoDB" id="10251401at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005554">
        <property type="entry name" value="NOL6/Upt22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035082">
        <property type="entry name" value="Nrap_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035367">
        <property type="entry name" value="Nrap_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035368">
        <property type="entry name" value="Nrap_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035369">
        <property type="entry name" value="Nrap_D4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035370">
        <property type="entry name" value="Nrap_D5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035371">
        <property type="entry name" value="Nrap_D6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972">
        <property type="entry name" value="NUCLEOLAR RNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03813">
        <property type="entry name" value="Nrap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17403">
        <property type="entry name" value="Nrap_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17404">
        <property type="entry name" value="Nrap_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17405">
        <property type="entry name" value="Nrap_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17406">
        <property type="entry name" value="Nrap_D5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17407">
        <property type="entry name" value="Nrap_D6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="15 16 17" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Nrap protein" evidence="7">
        <location>
            <begin position="140"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="8">
        <location>
            <begin position="295"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="9">
        <location>
            <begin position="445"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="10">
        <location>
            <begin position="635"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="11">
        <location>
            <begin position="824"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="12">
        <location>
            <begin position="988"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1107"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1117"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1131"/>
            <end position="1145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS22173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="6RXV"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="6RXX"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PDB" id="6RXY"/>
        </source>
    </evidence>
    <sequence length="1171" mass="130923" checksum="671489E45F71908D" modified="2011-10-19" version="1">MDAAPAKRRKIAHPDGNASIALEAAQAAATGVSRARAFVLETEEMLDSVDLDYSEAFDGADALLHRLKGSIETIPAHDAQPLLDAAAKLEKKHKLKVPFPSPPPPQNSNYKVSFATPAQFNVVGSYVAKTMVRTQSAHGIDMIVVLPESILQEKDYLDLRYFYKRAYYLAVVAAHLQKDLKGEATLSYEYHNGNSLLPVLSVKPNGEKDEDEKKKKKGVLDYRIRIIPCAPESFFPRQKLHLGAGLVRKHKEGEQQANGQPATPATPFYNSTLVAESSYLQYLKLLRQTEKKCAAFRNACILGRIWLQQRGFGSDVSKGGFGYFEWAVLLALLLQGGPADTKGAAPLSPSLSSTQLFKALIQFLSVTNFAEKPCVLGQAKPDLAGFIENGPILWDSARQLNIAFKMGPWSADLLHQHARWTRKLLADGAVDQFQPTFILKADLPTHTYDLVARMDPEKVSEAAPDKVAHEARGRHWQVGHKVYRILRRALSDKNMEGGERARLIHLKVSPGFSSSSWSLNEKPQPQKAGTPIEIGVLFDPLNMARTVDRGPSAGPSAEEKETCEKFRRFWGEKSELRRFGGDTIRETLVWSAQTPFDLCEEIMRYILGLHLRVGQLQDDIVFYGRSLPALLSIKPSDTALFNVARKTFTSFERDLRDLEDLPLRIRHVNPICPELRHSSLKTPSFGPSKSGPRPMEVVISFEASGKWPESLIAIQRTKIAFLLMIGRLLERFKPGEIRTHVGLDDARYETENLAFLDVIYASGACFRVRIQADLEESLLERQTKDKTTEQYLRQRASTQLASFRRTFVHLPLHTQYITTATTRFPALSPTIRLVKHWFSVHKLSNHFPPELLELFVLHTFLAPYPWDVPSSPTTGFLRTLLFLARWDWRTDPLIIDTSLNGELPAQERQAIATRLDAWRKLDPGMQHTVLFVATAHEQSGTMWTSVDGHPRPSKVVAARMTALAKSAARVIREQGVDLDVRRLFVPSLKEYDVLLYLNTKVLKSALRTYITVDPATEMNGGKGQEIKFKNLAPETVEPPLPVAQHPVDVLLKQLSAVYDSAAGASGTGPLVFFRSDTTATEEGDKVIGAVWNPTLVKRKWRVNLPTSYKPVAGGKDESEDEDEDEDEDGSEREKEREGEGRVEVEVNREGILAEVARIAGEVVERIEVKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2R2</accession>
    <name>G0S2R2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0018160</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692314.1">
        <property type="nucleotide sequence ID" value="XM_006692251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2R2"/>
    <dbReference type="GeneID" id="18255854"/>
    <dbReference type="KEGG" id="cthr:CTHT_0018160"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_0_5_1"/>
    <dbReference type="OMA" id="MTWIACA"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF134">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS22295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="50310" checksum="C5C3C8029236CB30" modified="2011-10-19" version="1">MILAPLSELNGRYPVFVVAGTVFVVCQALCGVVRTLAGMLVVRFFVGAGASVFSSMVGGVIADMWDARERNMPMAVFSGAVLAGTGAGPLVGSVMAERLAEGNKWRWVFWHQAVAGGLLMAALAVMWRETRGSVVLSRKARALNRWYEALEGRGYYGVWVEEGMGGEGDEEKRMGTTQEGSKLRRIRWVVKEDEERASLATMIRISVTRPFHLLFTEPVVFFFSLWAAFAWGVLYLTFGSVPYVFQTVYGWPLSGSGYAFSAMVIGAVVATGMGIWQEKLLRHPKWASPAEDGTNSSEEIPSPLPKLPPSKLDPFWAYLRAHFPPSTPESRLYPTCLTSTLLPLGLFTFGFTAQPQLSPAGPLVGIFLSTLGIFSVYLAVFNYFADTYQGYASSALAAQSFCRNVLGGAFPLVTRRLYGDLGPVKAGAVLGGVAVVLTGVPWVLVLLGEGVRGRSGFAKKLVHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2T5</accession>
    <name>G0S2T5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">deoxyribose-phosphate aldolase</fullName>
            <ecNumber evidence="2">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0018420</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692337.1">
        <property type="nucleotide sequence ID" value="XM_006692274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2T5"/>
    <dbReference type="STRING" id="759272.G0S2T5"/>
    <dbReference type="GeneID" id="18255880"/>
    <dbReference type="KEGG" id="cthr:CTHT_0018420"/>
    <dbReference type="eggNOG" id="KOG3981">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053595_0_2_1"/>
    <dbReference type="OMA" id="AAYCVNP"/>
    <dbReference type="OrthoDB" id="70823at2759"/>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00114">
        <property type="entry name" value="DeoC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028581">
        <property type="entry name" value="DeoC_typeI"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF1">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001357">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Schiff-base intermediate with acetaldehyde" evidence="8">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001357-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS22318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="269" mass="28987" checksum="BD480A671F238957" modified="2011-10-19" version="1">MATKPATARITVSLRDIAQCIDHSLLQPSLTDAEVEAGLCIAKEYGVAAACIKPYCIPAARKAFAGSSVRVCAVISFPHGNSTTSIKVAEAREAVQAGAHEIDMVVNMGKVLGGDWDYVREEIRAVNDAVTGTRVADEPDGETGLLKVIFENDFLQDEHIVRLCQICTELRVAFVKTSSGYGFVKQRNGMYTYKGATIPHLKLMKEHSGPEVQLKAAGGIRTLDEVLAIMSLGVSRIGCSATVAILEEAKQRGITNEPTEVEFSFPEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-12-14" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2X3</accession>
    <name>G0S2X3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0018820</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692375.1">
        <property type="nucleotide sequence ID" value="XM_006692312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2X3"/>
    <dbReference type="GeneID" id="18255920"/>
    <dbReference type="KEGG" id="cthr:CTHT_0018820"/>
    <dbReference type="HOGENOM" id="CLU_1786631_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS22356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="145" mass="15812" checksum="675F842A79F374FB" modified="2011-10-19" version="1">MGALSHQRCEETIDATTVKAAEKHPLNFASDGTESFPAALVVAVPKKRLAPAPAESHGLAGPELKLCANACLVLRPPERQPGRARDCLVRGCKSEERSTIRCLNTFRNNIAPYVDLLELRYTGKTGLGIFSRPGCFIPKYTFISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0S329</accession>
    <name>G0S329_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase S8/S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0019450</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692431.1">
        <property type="nucleotide sequence ID" value="XM_006692368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S329"/>
    <dbReference type="GeneID" id="18255983"/>
    <dbReference type="KEGG" id="cthr:CTHT_0019450"/>
    <dbReference type="eggNOG" id="KOG1153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011263_1_0_1"/>
    <dbReference type="OMA" id="VDILSCW"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000007">
        <property type="entry name" value="Subtilisin-like serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="7">
        <location>
            <begin position="72"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS22412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="344" mass="36670" checksum="EC22DFA2E1E82D0A" modified="2011-10-19" version="1">MKRISTIDYIEKDTVVKATRLSHAIHVHPFYRRIPTPAKRDTITQPHAPWGLARISHRARNFADYVYDTSAGQGVRVYVLDTGIRTTHAEFLDDPWELANSTTTNGTTFFGRSRAIWGANFVENTPDIDEDGHGTHVAGTIAGRTYGVVKKATVVAVKVLDKTGSGYMSGLLQGLNWAVSDATKRGVASRSVINMSLGGPYTQSVNEAVKAATDMGITVIAAAGNDRANASEYSPASASTAITVGAIGRDDYKADFSNWGPGVDIFAPGVTIPSAFAEHDNATLMMSGTSMAAPHVAGLAAYFLAKDNLKGYTEVSRQLLELATAGVGDKGDAPDRIAYNGNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0S388</accession>
    <name>G0S388_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Calcofluor white hypersensitive protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0020100</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692490.1">
        <property type="nucleotide sequence ID" value="XM_006692427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S388"/>
    <dbReference type="STRING" id="759272.G0S388"/>
    <dbReference type="GeneID" id="18256048"/>
    <dbReference type="KEGG" id="cthr:CTHT_0020100"/>
    <dbReference type="eggNOG" id="KOG3979">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009808_0_0_1"/>
    <dbReference type="OMA" id="CVWYFPL"/>
    <dbReference type="OrthoDB" id="68581at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000031">
        <property type="entry name" value="Calcofluor white hypersensitive protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057315">
        <property type="entry name" value="Exo_endo_phos_PGAP2IP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051916">
        <property type="entry name" value="GPI-anchor_lipid_remodeler"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053912">
        <property type="entry name" value="PGAP2IP_TM_1nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053911">
        <property type="entry name" value="PGAP2IP_TM_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859">
        <property type="entry name" value="CALCOFLUOR WHITE HYPERSENSITIVE PROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859:SF1">
        <property type="entry name" value="PGAP2-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23022">
        <property type="entry name" value="6TM_1st_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23021">
        <property type="entry name" value="6TM_2nd_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23226">
        <property type="entry name" value="Exo_endo_phos_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="409"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="454"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="520"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="543"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="573"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="608"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="652"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="2">
        <location>
            <begin position="19"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP first transmembrane" evidence="4">
        <location>
            <begin position="279"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP second transmembrane" evidence="3">
        <location>
            <begin position="451"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP C-terminal nuclease-like" evidence="5">
        <location>
            <begin position="685"/>
            <end position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS22471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="963" mass="107948" checksum="778FB6C93E31BFD8" modified="2011-10-19" version="1">MASRYKDKDAGAVLSFSGQWVSWSHTAFAYLAFLSALIIGCSLHYHKIVQNEWYGYPQEWFPSVSATIGDRYPERSIFMIAIAITSGPRFALVGLWYLLTAKPGHTLPKAVAISGLIRTLTCGGWTYITSTDDHDWHDILMISYIIFTLPWTTGCILLSPPNAKAIKYRKYIAGAFFGTLVPLIYFFIQHKVHRVPGAYTIYAFFEWSLIVLDVAFDAVTALDFDTFELVVKDVKGMSKGSNNSSVPAAVLEKEKEKPVFVGFRLSDALDIAADVYHGFVFWSVLTSLGLVIWYFPLWHMGISGYEALVLTTITPAFLGIKMFRSLVVQNQRFFHLLALSGLAAYLVKDPVYRLFTVGFGVATGCLAWVATLLADSAQPARLETRILAWTIGLIMSSVAKFAWHTNNPVWPIMHAANGGWNGTGLVFGILAALRFTRRAPLSGGDAPQEKNGSSLLSALSIGGLFFGLHSLLSDTSTMISWVWDGYPVRGPVANVHGWYTIIAMTIGVAIGVLRPDLVTSWTAYGVACVGAAILTIYPHWFGYYGGLTLAMYLMAVAFPLISSAAKKNVAVTFGLGFMIYNLLVLFHVWVVAYAFVPGGPLVREHTDWIMITMMLSIGAGVFDLISQQARSGRKTVKASDRTRPSATGHRRYHAGVLGFLHLFFLLANVRRFPSNDYKPHHANDRLITAGIWTIHFYLDNDMWSSEYRMRDLIKELEIDVIGLLESDTQRIIMGNRDTSQFLAEDLGMYVDYGPGPNKHTWGAALLSKFPILNSTHHLLPSPVGELAPAIHATLDVYGTLVDVFVFHSGQEEDPEDRRLQSEYMAKLMGSSPRPSILLSYLVTRPLEGNYNTYVSQTSGMKDVDPTDWDRWCEYILYKGLRRTGYARISRSTITDTELQVAKFVVPSNEEEQAKAWDVSEELRMRRVEEHEVPEGWRFPQMFRGEGVRGHRYHVFDEPRYYNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3J3</accession>
    <name>G0S3J3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0021460</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692616.1">
        <property type="nucleotide sequence ID" value="XM_006692553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3J3"/>
    <dbReference type="STRING" id="759272.G0S3J3"/>
    <dbReference type="GeneID" id="18256184"/>
    <dbReference type="KEGG" id="cthr:CTHT_0021460"/>
    <dbReference type="eggNOG" id="ENOG502T0XV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_460030_0_0_1"/>
    <dbReference type="OrthoDB" id="4584806at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="399"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="516"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS20320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="593" mass="65270" checksum="62554EBE63C822BB" modified="2011-10-19" version="1">MTATNLRTPFYPLQTQYHRQTHRIRDTGRQRDSTVALTIAPHKSDERNIIQRRFQFQLQLRGIHDDHFQRAQVFGEIFKTPPNEQLLIELQSFDAFQTCSTKGDYGKCLSTASPNSCGCEHGIKYLDCVEDALEKSKCHFFVGITDWSAWERTWVQEACSTPPSSVMTELKQPTTVEVSYATVPMVTLTSTPTSLLDLITLPPHIITATPTLTSLGAPLLFDSAGDANPCATPRYTLLHAGDIVFYAAFVGCGADKPECCPWEVATTTTELPLGSTEGGGAPAGDRFKVIVQGGPGQLPLPKDLAKEGKLERCPGDYYTVRGEGICCPNGYFKFTRTIASQTACFSSLKDAATPPPVTSGLAANPTDTLLPTSAILNLAWAMAFNTTQDNDDPPVSTGAAVGIGIAAALVLFSFVGLLLFWFLRRRRHQRLARGEIPPTREKEANRLTGATIHSNMQFRPYSEGPPRLEIRSVSRGMPTITVSPYDDQMQAHRDHDIYPYRDHVTEGMTYTRGYHAPPTASVSTPSSPPSHYSAPSPPISPPPQDIGIGTVPGAEQKGSYWTETEENMGSYWARKRDYQIHDQTLPPRRTSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3K3</accession>
    <name>G0S3K3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Twinfilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0021560</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with G-actin; ADP-actin form.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692626.1">
        <property type="nucleotide sequence ID" value="XM_006692563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3K3"/>
    <dbReference type="STRING" id="759272.G0S3K3"/>
    <dbReference type="GeneID" id="18256194"/>
    <dbReference type="KEGG" id="cthr:CTHT_0021560"/>
    <dbReference type="eggNOG" id="KOG1747">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031995_0_1_1"/>
    <dbReference type="OMA" id="YLFKHTH"/>
    <dbReference type="OrthoDB" id="10006997at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11284">
        <property type="entry name" value="ADF_Twf-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11285">
        <property type="entry name" value="ADF_Twf-N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000042">
        <property type="entry name" value="Actin depolymerizing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000007">
        <property type="entry name" value="Twinfilin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028458">
        <property type="entry name" value="Twinfilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759:SF1">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ADF-H" evidence="11">
        <location>
            <begin position="3"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="ADF-H" evidence="11">
        <location>
            <begin position="177"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS20330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="333" mass="37148" checksum="D2BF89088E3E6A11" modified="2011-10-19" version="1">MQSGISASQELVSQFNKLLSSDEHFGLLVTIKSEQLQPLTLLTPPSRDASFATNLNTLLAPHIKHNEALYIILRRHTSTPALVAITYVPDPAPVRQKMLFASTRLTLVRELGSEHFRESIFATTAEELTPAGFEKHDAHTALEAPLTEEERTLGAVRRAEQEAGMGTASRPLHLSSNMTTTIADPALDALKELAAEKRSLVMLKINPDTEVVELEPGVTVPSSITELVQAISPMDPRFVFYRYTHTYNGVESSPLLFIYTCPSNASRKAIRFRMMYPLMKRSVLEIAEKEGLKSEKKFEVEDPSEITEQSVLDELHPKVEVKKGFSRPKRPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3N4</accession>
    <name>G0S3N4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0021880</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692657.1">
        <property type="nucleotide sequence ID" value="XM_006692594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3N4"/>
    <dbReference type="STRING" id="759272.G0S3N4"/>
    <dbReference type="GeneID" id="18256226"/>
    <dbReference type="KEGG" id="cthr:CTHT_0021880"/>
    <dbReference type="eggNOG" id="ENOG502RXTA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014722_0_0_1"/>
    <dbReference type="OMA" id="GNPMYRT"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF13">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409277" description="CBM1 domain-containing protein" evidence="5">
        <location>
            <begin position="24"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="6">
        <location>
            <begin position="372"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="337"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="346"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS20361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="408" mass="44339" checksum="13FDA41B227FA2EF" modified="2011-10-19" version="1">MMLKSHGLLAAALALAGSPGAEAVLRFSCSQLVVERLDPLVFPGVFQSPHLHQVVGGNMFNVTMDPNRHNIGEEATCTTCTFSEDFSNYWTATLFFRARNGSYIRVPQRPNIGFDGARGGGMTVYYTASFMPGPVNNVKAFAPGFRMIVGNPMYRTAQEASKYRQLTFTCLDNMFTRTGETPTMPTRPCAEGIMANIRFPTCWDGKNLDSPDHESHVAYPESGMFETGGPCPASHPVRLPQLFYEVIWDTRQFNDLSLWPEDGSQPFVWSYGDFTGYGTHGDYVFGWKGDSLQRAMNANCDDCVGVLKTQSIQQANQCRQEQKVKENIDGWLSELPGKVQVTGPQPGTGPGGGNNGGGNNGGGNSGGGNSGCTVPKWGQCGGRSYTGCTTCAAGSTCRYQNDWYSQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0S442</accession>
    <name>G0S442_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0030620</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693512.1">
        <property type="nucleotide sequence ID" value="XM_006693449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S442"/>
    <dbReference type="STRING" id="759272.G0S442"/>
    <dbReference type="GeneID" id="18257100"/>
    <dbReference type="KEGG" id="cthr:CTHT_0030620"/>
    <dbReference type="eggNOG" id="KOG1466">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
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            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGS21216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
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</entry>
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                <person name="Flemming D."/>
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                <person name="Kunze R."/>
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            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
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    </reference>
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            <begin position="1"/>
            <end position="50"/>
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    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="EGS22074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="153" mass="17652" checksum="516D85674BB819A3" modified="2011-10-19" version="1">MDSAAAKDTTSDTSNDDPHHSKRAHDVMSANGAQVDATKPRVLKHRKKLQTQPELDDDAWKWLVEKRGCLPPTRSIIAWPELAANRSMPLNGYPATKEFAAYKLSQDPHEFRWYSYRCPPERFLDDPVTAQPLQTKSLHFLKWLSHMERYHPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4K6</accession>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
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                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
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            <end position="53"/>
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            <end position="112"/>
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            <end position="133"/>
        </location>
    </feature>
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            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
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        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGS21281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="196" mass="22793" checksum="8E0E9CEC98440C9D" modified="2011-10-19" version="1">MPSQEQRKKEKDQKHKAKAPEPATNDQEKKALKAAPPPLVPVEPGDESEDYSEDVSKDEEQRVLDENYQDGTPGSSRRAEADEDERSEEEADEDQAVQTAREEESEEEEEESPALSQPSTPRDDEKPRPKWMDQRLQSAKKADQQMEPACQTRQQVHHEQRQRNISGQRDYNSQLTYRKEQEMMMQPQQQPQVQTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5F7</accession>
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        <submittedName>
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    </gene>
    <organism evidence="3">
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
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        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
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                <person name="Sarges P."/>
                <person name="Flemming D."/>
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                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21422.1"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="18257318"/>
    <dbReference type="KEGG" id="cthr:CTHT_0032800"/>
    <dbReference type="eggNOG" id="ENOG502T2Q4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026446_1_0_1"/>
    <dbReference type="OMA" id="APSAMKQ"/>
    <dbReference type="OrthoDB" id="5225441at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="240"/>
        </location>
    </feature>
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        <location>
            <begin position="255"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
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        <location>
            <begin position="179"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="269"/>
            <end position="310"/>
        </location>
    </feature>
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            <end position="387"/>
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            <begin position="469"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGS21422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="507" mass="52934" checksum="CB4DA9F0289B2F72" modified="2011-10-19" version="1">MSLFDKIKRSLEAAKKHQAQQAEKQNKESTAPPYKHVPTHAASDALLGGPPTWREMDRPKIVEANKRRSVLTANGIGMSGIYTPVHAGMPRVSSNLSHVSYPSAYANPVVHLPRNYSYSSIPPAWSYQNREMHYGLAEGGTLKGKEIGRIRFDHGYPSARASRSSSKVSTKRIYRESGPSPDSPSENANDSSSSQDDLEMKPVRHPASHSSLKTASSSRRPASDIGSPHRLHPSHARRVSDLDYGRSAYVVPRTPSFGSGIPPVPSIPPSIVGAAASSSRASSAGSSSGSSGNESNASSTTAPSSTSPSEDVTPATSATISKDQVAPSSSSKDPRPESSSAQTTTGTPAPATETQAPAPTTTALTAHESSAPKPTSSITARSSSSPPERAKKVKPSVPVAVEEEENEIVPPPSLEQAKAQQRQAAAAMAAAVSTAAIAPAPSVVEEAPKKAEKVTAAAAKPKSVKSGKLTKTLATATATPSVQQTKPEKKSRWSLSLGRSKSAVAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5I3</accession>
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        <recommendedName>
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        </recommendedName>
    </protein>
    <gene>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CUE1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EGS21448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006693681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5I3"/>
    <dbReference type="STRING" id="759272.G0S5I3"/>
    <dbReference type="GeneID" id="18257344"/>
    <dbReference type="KEGG" id="cthr:CTHT_0033060"/>
    <dbReference type="eggNOG" id="ENOG502S2DP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083690_1_0_1"/>
    <dbReference type="OMA" id="RRDIMWD"/>
    <dbReference type="OrthoDB" id="3824970at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000050">
        <property type="entry name" value="Related to AMFR protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="12">
        <location>
            <begin position="55"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="98"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="158"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS21448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="220" mass="23537" checksum="67EF25AD5875FAFD" modified="2011-10-19" version="1">MDYDDSAQISLSSLVVIIVISGLLIRYLFFSGGNGNGASGSRAAAARDPLAAARAREAAVERIQQMFPQLDRRTVLWDLQRTGGNIQLTTERILAGRLETPPPTFQPPPPPPGTATSSSSTDNNNNAGATNNSSSATPSSTPLQSQPDLITRYNLHDKLNQPLPADDPASAGKKAWSSSREERQSILQRRRDQMILEARRKMEAKLAAERAAAAATGGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5S5</accession>
    <name>G0S5S5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0033450</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693783.1">
        <property type="nucleotide sequence ID" value="XM_006693720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5S5"/>
    <dbReference type="GeneID" id="18257383"/>
    <dbReference type="KEGG" id="cthr:CTHT_0033450"/>
    <dbReference type="eggNOG" id="ENOG502QPYF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018583_0_0_1"/>
    <dbReference type="OMA" id="FFKHMPT"/>
    <dbReference type="OrthoDB" id="5397682at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33604">
        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33604:SF3">
        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS21487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="555" mass="61906" checksum="96AB0FAA0CC5451D" modified="2011-10-19" version="1">MTALFTAQDDFGKKDDDRKPAAGMSTQIIWSPVNRIAPRKMIKRIILLLGTGLLIYLFIHNIPTDISPRDRRHPVFLPPEKSRHRNPPRPGPMPQFKPGGQPLKPNTPPLDPKVLEDQQNVPRSYDGPIVFPKLSSSLNAIYDTDGTSMINKNVLFAAASLQSASLLLPLACKMGSERRNYVHFALMGGSYITLEDLRAVNGIGDGCHIIFHDARPDFPATSTIERLKKSVGSALYHIINYMHPQSIFIDSSGAENDYLLAEIRREASISGTSVIELPADSLSKLSWIANLDSSSLAAWNKVNIDILIHVSPGTTGSLVHLLKSLSKADYSVGPVPRLTIDLPANIDPVTTNFLTTFQWPPRSANGVSQPQQLIIRRRISRGRQTEEESTVRFLESFWPINPKQQLPAFFTQKMVSKNFPAWMEHALTLSRVRGYWMLYPGAKTATKIATFHQEFYRAPEEFEKELAKTTPQYSEPRLDQGALFETLPGRGNLLPFSDMPLLFWDGTPTQLKVLDTAAADYANEFRRAVGGCEGLDPEELVPSSSLQDLFCVEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0S607</accession>
    <name>G0S607_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">PQ-loop-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0025590</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the laat-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693019.1">
        <property type="nucleotide sequence ID" value="XM_006692956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S607"/>
    <dbReference type="STRING" id="759272.G0S607"/>
    <dbReference type="GeneID" id="18256597"/>
    <dbReference type="KEGG" id="cthr:CTHT_0025590"/>
    <dbReference type="eggNOG" id="KOG2913">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019699_1_1_1"/>
    <dbReference type="OMA" id="DMCIFIQ"/>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098588">
        <property type="term" value="C:bounding membrane of organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015101">
        <property type="term" value="F:organic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034488">
        <property type="term" value="P:basic amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034490">
        <property type="term" value="P:basic amino acid transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000011">
        <property type="entry name" value="PQ loop repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF35">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER YPQ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="133"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="377"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="398"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS20723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="45530" checksum="FBF605EC6AD61EE8" modified="2011-10-19" version="1">MGHTGSTGANLVRKFTKGPYVMPSPRMAPPTGPLNLDVEAISGICGSISIACWVVVFSPQIIENFRRKSAEGLSIQFIVIWLIGDVFNILGAVLQGVLPTMIILAFYYTIADIVLLVQCFYYRGFTLSDYVPTQPSPPPSPPQKLRQRNGQHLSPPPTEHTGLLSRMPSHERLPYHSVEEHERRDSWTHLSPAVPFVPTEEPLPVPPPAPPTFWQSIAFNSLAILMVCAAGVAGWWLSRNYEDRVVGGSPPNGDSPVGNDPVDMDPLGQTFGWLCAVLYLGSRLPQLLLNWRRKSTEGISVLFFLFACLGNLTYVLSILAFEPRCVADESCQPGEVARLYWQNILVNSSWLAGSAGTLLLDMAIFVQFFLYNKPEEEYESSSSDNGSSDEESLEGESWDQRPLLERESTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6L9</accession>
    <name>G0S6L9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0026680</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693126.1">
        <property type="nucleotide sequence ID" value="XM_006693063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6L9"/>
    <dbReference type="STRING" id="759272.G0S6L9"/>
    <dbReference type="GeneID" id="18256706"/>
    <dbReference type="KEGG" id="cthr:CTHT_0026680"/>
    <dbReference type="eggNOG" id="ENOG502S564">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052686_0_0_1"/>
    <dbReference type="OMA" id="LTHFSMR"/>
    <dbReference type="OrthoDB" id="527344at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46504">
        <property type="entry name" value="TRNASE Z TRZ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46504:SF2">
        <property type="entry name" value="TRNASE Z TRZ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="58"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS20830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="359" mass="39840" checksum="81E3449FF0DF8484" modified="2011-10-19" version="1">MASFATPLRQSSRSEILEWRFPKPFSHITLTGRSRAAWHTSFVIPQLNLLLDAGLCVNNLRPKHIFLTHGHSDHTLLTPAFVKREDPPDIFCPAEMKQVLDNFINANTVLNLGGLWTLGDLETDLSSSDLESTNSSDSSGSGNGPGDGLLRTHITHPLVPSQTVTLRRLVGGSGNSAKPSWTATAFACDHTVPCLGYVFHQITYKLKPEYRSLSPAELRTLRQSIGSDITQPVATPVFAFLGDTTALTLDQNPEVQKWLEEGLKVVITECSFLREEHRAQAEKTKHTLWADLEPIIRRWPNTTFILMHFSLRYTDEEIRTFFKELGDKVPSNVVVWIDGEGDDEPGLNGGSGGRSKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6W9</accession>
    <name>G0S6W9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0027150</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693173.1">
        <property type="nucleotide sequence ID" value="XM_006693110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6W9"/>
    <dbReference type="GeneID" id="18256753"/>
    <dbReference type="KEGG" id="cthr:CTHT_0027150"/>
    <dbReference type="eggNOG" id="ENOG502QQEZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020826_1_2_1"/>
    <dbReference type="OMA" id="TAETWAH"/>
    <dbReference type="OrthoDB" id="442243at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842:SF1">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="9"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS20877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="404" mass="43571" checksum="DC3C043F912185AF" modified="2011-10-19" version="1">MKKTLLLCFIHGFKGGDDTFGKNYSFVEHLRKRLATSLPRVNVEAIVYPKYETRGDLGECASRFRDWLINKVIDLEVAAGTTSPTVDPSVRVVLVGHSMGGIVAAETTISIASEHPIHNSVDEDSPNKSGTATPPAPNPFMFPYIQGLLAFDTPFLGISPGVVAHNAESHYATAVTAISQLSSLAGLWAGGKASQSFSSGSSKALVPKENKEKSGGSGWGKWGTIAMAAGAISAVAAGGVAAYYNKEHISHGLNWVTSHLEFVGCLARKEELRRRVAYMLRLNRELGVGFGNFYTRLGQAASSKQVSMVGTVLGNERTFCIVPRQELVGDWREAVNDKAKDEIWAHMSMFEPEDNPNFDKLAAEASAMVASWVPDDWYDAGSTNDTPQSEGDREQPPLLALPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0S705</accession>
    <name>G0S705_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Guanylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0035690</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the guanylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693999.1">
        <property type="nucleotide sequence ID" value="XM_006693936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S705"/>
    <dbReference type="STRING" id="759272.G0S705"/>
    <dbReference type="GeneID" id="18257607"/>
    <dbReference type="KEGG" id="cthr:CTHT_0035690"/>
    <dbReference type="eggNOG" id="KOG0707">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001715_0_3_1"/>
    <dbReference type="OMA" id="EWAVVHG"/>
    <dbReference type="OrthoDB" id="6334211at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:GMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000776">
        <property type="entry name" value="Guanylate kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00328">
        <property type="entry name" value="Guanylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117:SF13">
        <property type="entry name" value="GUANYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117">
        <property type="entry name" value="GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="9">
        <location>
            <begin position="8"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS21703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="197" mass="22187" checksum="97E32CC47C90B191" modified="2011-10-19" version="1">MARVVRDTRPIVISGPSGVGKGTLYGLLFQRHPDTFTLSVSHTTRPPRPGEQDGVHYHFVTREAFLELKAKDGFVESAQFGDNLYGTSKATIEEQMAKGKTVILDIEIEGVKQIKASGFPARFVFIAPPSEEELERRLRGRGTEKEEAIQKRLRQAKVELEYSKVPGMHDKIIVNDDLEKAYKELEDFVFAEPLTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G0S723</accession>
    <name>G0S723_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone transcription regulator 3 homolog</fullName>
            <ecNumber evidence="4">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0035880</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2024" name="Mol. Cell" volume="84" first="2601" last="2617.e12">
            <title>Structure of the Hir histone chaperone complex.</title>
            <authorList>
                <person name="Kim H.J."/>
                <person name="Szurgot M.R."/>
                <person name="van Eeuwen T."/>
                <person name="Ricketts M.D."/>
                <person name="Basnet P."/>
                <person name="Zhang A.L."/>
                <person name="Vogt A."/>
                <person name="Sharmin S."/>
                <person name="Kaplan C.D."/>
                <person name="Garcia B.A."/>
                <person name="Marmorstein R."/>
                <person name="Murakami K."/>
            </authorList>
            <dbReference type="PubMed" id="38925115"/>
            <dbReference type="DOI" id="10.1016/j.molcel.2024.05.031"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.90 ANGSTROMS)</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Has a role in a nucleosome assembly pathway that is required for the integrity of heterochromatin and proper chromosome segregation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HIR3 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="4"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694017.1">
        <property type="nucleotide sequence ID" value="XM_006693954.1"/>
    </dbReference>
    <dbReference type="PDB" id="8GIX">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.90 A"/>
        <property type="chains" value="D/E=1-2235"/>
    </dbReference>
    <dbReference type="SMR" id="G0S723"/>
    <dbReference type="STRING" id="759272.G0S723"/>
    <dbReference type="GeneID" id="18257626"/>
    <dbReference type="KEGG" id="cthr:CTHT_0035880"/>
    <dbReference type="eggNOG" id="KOG0417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001419_0_0_1"/>
    <dbReference type="OMA" id="WETWYRL"/>
    <dbReference type="OrthoDB" id="77564at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000417">
        <property type="term" value="C:HIR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000060">
        <property type="entry name" value="Ubiquitin conjugating enzyme (UbcB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033053">
        <property type="entry name" value="Hir3/CABIN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502:SF7">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="15" id="KW-0002">3D-structure</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="12">
        <location>
            <begin position="2065"/>
            <end position="2215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="331"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1678"/>
            <end position="1760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1788"/>
            <end position="2026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="351"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1740"/>
            <end position="1749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1788"/>
            <end position="1805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1823"/>
            <end position="1835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1886"/>
            <end position="1903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1941"/>
            <end position="1970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1979"/>
            <end position="1998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="2007"/>
            <end position="2026"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS21721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="8GIX"/>
        </source>
    </evidence>
    <sequence length="2235" mass="250364" checksum="7E7483F8A1C2B14F" modified="2011-10-19" version="1">MAAFSAINVEPEDNVDEEYDTTKEVQVEEALKLFQTALKLHAQGPQFFDQASRAYAALFQSEIFKYPESKTDYERAEAGQDVAAAAFIPGVEILGADIDGASTLPQTFYLSYKNHGQFILDRIKHRTRTENIGKEELLNDADVRKDAYQALYNFCVALDRDPSDADLWRKAARLAAFLRSPRITRYSLEAAIEMDDDPAVDEVNPPSLAEGFAGEQLKQQLQVLDDKIALTHPIMKPFLEKDIPPYLAEYLDPMPFLPDPSKQLAVPGQQSPSVENARLTIGLSNISWTELGTALVNLAKEEGLSSKGISIQLPATSSDEDVQMEVDAQLQLPKSQPPPAQLDVGQVDGDNTEHPAEVGVKVEEPEPAELEPASANDESSKDQGSSRKRSQSAAGIPDTQEDEAADLKRSKRTRRRDTTADEAMDSATFFATQLQPLQAADQNLFQATKNLLENLGVTDRVTLDRIAEVLDSCASDDRTSKFQNPATVDLRNALMNFDEDVAAILLNQRELPQLNLSTFLEHAKSGSQRALEAPAFDDARGLRGFVERLGDAWNTIHDVAYGYVKALADFYTDFKWSEPLRATVIQLINSLDSSIYDGIVHDLEACQSITKDSSFSKLASLAQMLLELHLDVLDRVNESNGSAEEITKVEAKGRLRRWMELVTKVLRMRDLEQAGTLPLRYLWAAVTSTTLAKEAPREHILNCWYSLRDYLTGSVSAEISLPNNSVMPEISLSAADREISKLTTMDFFLGIFQEEMSDPVSVIENLEPVLSPESVQICVPVSETDSLENSNDTSKSKVKKLPITECASQELLDLWKFLNSSSTELRLLLWSRLAEAYGRIKYTTKQFSCFLRSIEVIVADFEGEEYASTPPEARKTLFMGMLKALDDLIIQSLHLALNDNSSFDIIDEDHLRSSMSAIAKVSCMLHVAAMYEDEGRIGILPSPANGSPQKSFLNKLQEMQVRTWSLQYTMLKVGINQHPDIFPKPENDLAEFLAAVHQVLGLRKCCKSSNRIFLKMMRVELLKQKNIENWEDYLGQVLYDLHGLKLGVGVWDVQDHGCEPENLEKRQALQLVEKVAMLANRMSMKDLLKSDLKTTIERMQQAIGSAKSSPQMSHNLRNYTEYLKSPIHPLHMYQALTGGVHLDAVSINTPESAPAKQGWFFLLGMIALTKFKGVDLNRRQTPGATDDLRIAATFLRLQLQYTPDRWDAWFRLAECFDYELEEAVLWTADKMNKERAELVKFQRHAIHSYIMALSHSYAWASNPAALTSLEDDEEALYDMYHEFGMRLYSSSREPFAMEPFEHGDHKRFFIEPEGAGTYKKIVHNQMTDYQVWKFAAHLFRKAMVGKPKDWKNPYMVAKCLWKMYQKPTEELDEKNRRHRPTVQMVLDALEKTIEVVSALPKPRHGQEPILEPHYKIVSVIWKLVKRGDLSPQEATKVLQRQPYSPDHGKEVSVETAEDFKAYIIRCLRYLRDKDKSNWQHRLIIRHARVLFDENTDMNRPDAVEAAKAAFGVLRENMFTKTMVMNVWKCDAERPGRHHVYTERYIRYVVKLLDVMNDRTNMGALLRRIRKKGADFYHFNELWQYCVHTYVKLLRDTFNIPVSEEDVFKTLTPEEFDVVGEKIADWAATPDAENHDALGAMKEAVELKKLNANLMKAGLIDDLIADCYTAVYSYVRPELPRPERTPLPDTTPSSPKSENVPPPPADAVDLKSRLLHTLVTRDKEPSTSSILGSLRAGSSELQDRSEKHSVAGDVPQRAHRVGVGIRRPNIIRKAEQAVQAALRAAEGAAARAGTNGSSTGPSGTKSRVGSISSLRAGRTATRGEDEEDSEGDEDGDVEMKEAEGEGPIAGRRSRRQSNATNKSTGAVADEDEASDVSSPPGSLHDSADDESELSDVPADYEDDAPPALLFPNLRRSVDAGTPGSGEEDETETEHDTGNRSGEEEEQEEEAEDGSEEGDEDAAVEDHEENEETDKGVDVEEHADDEEGEEDIEETEEQGNDGDSKVQDDAMEVEGEEAEDSEATEEGDDSIIFTQQNHIVTSQSEQNGVPQAHRKSPYIPMLSPAPQPILTFSQELSECTTNPPTGMTIELPNEADLHRWHVTLEGPENTVYAGGKFGIVVTLPPEYPFKAPNITFATRIYHPNVTNDSLGHICLGLLKSENWKPSTRLASVLEAVRGLLVEPQPEDPLEARIADEYRRDRKEFEKNARTYVQRYAKGPVKWEDSVTSTTTASSGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>G0S746</accession>
    <name>G0S746_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0027400</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693197.1">
        <property type="nucleotide sequence ID" value="XM_006693134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S746"/>
    <dbReference type="GeneID" id="18256778"/>
    <dbReference type="KEGG" id="cthr:CTHT_0027400"/>
    <dbReference type="HOGENOM" id="CLU_1651961_0_0_1"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="160" mass="17601" checksum="AA8FD4BB9A6759B4" modified="2011-10-19" version="1">MSTTTAPGLDQVPANDLYDPEEVLLRNSPLLQPLRPNLRPDLSLESPSPSPSPSPPFGNRKPNQGYAVLIAHLDGHRQETSAYAEIEPLPSDPESDDCPGESEPRYLDNSPDDMSITEKGKLFEGQPGEDRSQTIGVNQEPSIYKCWANSPNNRTRHIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0S791</accession>
    <name>G0S791_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4048 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0027850</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693242.1">
        <property type="nucleotide sequence ID" value="XM_006693179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S791"/>
    <dbReference type="GeneID" id="18256823"/>
    <dbReference type="KEGG" id="cthr:CTHT_0027850"/>
    <dbReference type="eggNOG" id="ENOG502S19N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016967_2_0_1"/>
    <dbReference type="OMA" id="PWPAITK"/>
    <dbReference type="OrthoDB" id="4097086at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025122">
        <property type="entry name" value="DUF4048"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13257">
        <property type="entry name" value="DUF4048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="244"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="306"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="544"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="580"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="122"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="250"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="331"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
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        <location>
            <begin position="404"/>
            <end position="414"/>
        </location>
    </feature>
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        <location>
            <begin position="452"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="580"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS20946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="618" mass="66873" checksum="362ADB6744EBC3F7" modified="2011-10-19" version="1">MDEMVLLQQRSLDGAIPGPNRPSGTLHERRRSSRGGSRDETKPRRFPDESVSSATSQADDLIETRSSRSASTASRSTNRLSLTLPIAPPNPYPSRPTPLTATTPAFPPTPLDTPALMSPIDANDLITAIAAQERRVLELREELSRAEEDLARLKKQWATHEAYKKRPDRRATDPTRGIDAQDETAIRRSLELDRRRALLTQQQTSQAAPERSRRRVFTGTHTRQLSLLSPTKPDGLSDYDADRSKDDSDGNNYAASAYTSLSAPSSKRASWAPRSTQTSGVKQFAQDLKTGLWMFMEDLRQATVGDEPITGQGTYRRGLNGYSTGDQHTIRASSSNNSRPRASAVFDDSAPKAVAPNGESRQDGIPMDKDASQRSQRSKNEAPKSTKRFSWTPLSTDAYDDNDWSNWDNPSGSSLRWSGTTVNGDIIPSPPEKRREPETSTPIKKKSSKPRVASTSSSSSTSSSSSSSAASSSSVSSAPSAPASSSSSASTTGLVGAAAVFGGLKSPVVKQLEDLLPPMLNRLTPSNIKRTATDLMKEWERSLLPPDAMPNSSSRGQGVGAAAAAGGGTVNAPVAAVDGYSCHQQQQQQQQQQQQQSQQHLNHQQQQKRRGGAGEKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7D1</accession>
    <name>G0S7D1_CHATD</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0036430</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21775.1"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="18257681"/>
    <dbReference type="KEGG" id="cthr:CTHT_0036430"/>
    <dbReference type="HOGENOM" id="CLU_1337370_0_0_1"/>
    <dbReference type="OrthoDB" id="4138164at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS21775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="205" mass="22862" checksum="8061870E4718F22A" modified="2011-10-19" version="1">MLPNQENWKWCSKCAVLFYTGNAPCRANNGTHDLSGSSNYFIPINENAPGQKGWRWCKKCQVLSWVGNEIGSCQADGNHDISESSEYHVLLASDDDKEGWKADMKQYRKCQGLTYMDGEKKECVGGGHHDFSESGWYVLCSNGEPRSQAEIGHNQWHWCKDHQLLCHDGNTSCAAGVVHISVGSSNYKLKVALKGPTPNIQTGWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7H3</accession>
    <name>G0S7H3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF2264 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0028140</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006693208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7H3"/>
    <dbReference type="GeneID" id="18256852"/>
    <dbReference type="KEGG" id="cthr:CTHT_0028140"/>
    <dbReference type="eggNOG" id="ENOG502QU9P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028269_1_0_1"/>
    <dbReference type="OMA" id="SPYWCCK"/>
    <dbReference type="OrthoDB" id="5150166at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049237">
        <property type="entry name" value="DUF2264_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049349">
        <property type="entry name" value="DUF2264_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016624">
        <property type="entry name" value="UCP014753"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35339">
        <property type="entry name" value="LINALOOL DEHYDRATASE_ISOMERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35339:SF4">
        <property type="entry name" value="LINALOOL DEHYDRATASE_ISOMERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF2264"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF2264_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UCP014753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2264" evidence="1">
        <location>
            <begin position="33"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2264" evidence="2">
        <location>
            <begin position="388"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS20975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="677" mass="75560" checksum="38BB3B6ECB951D10" modified="2011-10-19" version="1">MATLTTPRTNTGHTGLVLGYSSAHPFSTIPLSDRTSVQDLLKALLDPLEPFFSPLKARIRCPGATAVRFDQTASEVEGICRPLWGLACLLAGGGEYRGTQWWIDGIRAGTDPEGPEFWGFPRDNDQRMVEMCPLGFALAVAPTIWEGLSERERENVERWLGNSINEKEMPNTNWLWFRVFANLGLKKRGAKFSQARLDADIEHLNTFYRGDGWSNDGPEGIHQMDYYSSSFAIHFLQLLYAKLAGDEDPERAAEFRKRAQIAALDLAHYYDEEGRSIPFGRSVGYRFAMVSFWGALAYADVELPAPLTWGMVKGIVLRHLRWWQTQHDIWSPSGTLTIGYSYPNMYMSENYNSPGSPYWACLAFICLAVPETHPFWTSPEEDHWTVIPRIKALKHPKHIMSNLGGHCMLLSSGQACSYPMKGTHAKYGSFAYSSAYGYSVPPGLFTLEQYALASQLGFSDDGGEFWKTRRVSKSTLEERPVTGPVLISHWEPFPDVHVTTYLLPPREETPNWHIRVHRISAGREVLTADGSFAISNERALDGRYLDPYNPATYEGTKPRLMGNYDPPTDEAVAPAREGAFAVSLKAGAVGIKALPDEKPGSEERRAVMVNADPNSNLVAARTTIPTLQGVIKKGETVWYVAGIYAKPKGPKEQALDGWDKLPEVPAWLKEEIAKDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7N4</accession>
    <name>G0S7N4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AP-3 complex subunit beta-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0036950</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694121.1">
        <property type="nucleotide sequence ID" value="XM_006694058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7N4"/>
    <dbReference type="STRING" id="759272.G0S7N4"/>
    <dbReference type="GeneID" id="18257733"/>
    <dbReference type="KEGG" id="cthr:CTHT_0036950"/>
    <dbReference type="eggNOG" id="KOG1060">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006320_3_2_1"/>
    <dbReference type="OMA" id="HFLVRST"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026740">
        <property type="entry name" value="AP3_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037096">
        <property type="entry name" value="AP3_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="7">
        <location>
            <begin position="37"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="550"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="671"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="715"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="550"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="679"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="715"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="739"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS21825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="804" mass="89142" checksum="C18E9A06A0CB0A5C" modified="2011-10-19" version="1">MESISRITSLIETAREFTLDAASIARTRSSYKPLDRAQVKRLLDSRNEREVLDGLRRVITMMYRGQKTLPLFSSVVKNVASSNLEIKKLVYIYLIHHAEEEPDLALLSINTIQKSLSDTNPQVRALALKTMSGIRVPVISQIVSLAIRKGAGDMSPYVRRAAALAIPKCYRLDPSQLPQLIEYLSTLLGDKQYYVAGAAVTAFMAVCPDRIDLIHKHYRTLVRMVVDMDEWSQLSTLRLMTIYARKCFPRRTKIVKIREKAPDLQGFYEDEKELSADGEQVIVLDPDHRLLLDSIKPLLQSRNSGVVVAVARCYSAIGTPEYMRAAVGPLVALLRGAQDIQHIALYNIVSICLSCPADFVKYATHFLVRATDPQPVWELKLEVLTLIFPHAPPHVKSLILNELEHFSRGSDKALVREAVRAIGRCAQKDLSTAPRCLRLLLGQITSLDGTLAAESLTVIRHLIQQDPNAHIATVIRLAKNLDTATDPQARATIIWLVGEFSGLNGEDNIAADVLRILLKDFASEPEIVKRQIVLLGAKVYLHHLNRQIEEAQSSQPSSDVPGDSSLSLPPQNSRVPKSLEEDNHPAAKLWRYLLQLVRYDTSYDLRDRTRLYKALLVVPQLATLMLLAPKPAPETPSPSETRKGFLLGSSSLVVAGGGAIHGIKGYRDLPPWVEEGQEPDPKLREREGDAVAAGRDSLGGKVPAAAILDATAAAAASSSGSKPGSRGANGIGEKTLDDWLAESEEEEAQQESEEDEEEEESEEEEESEEEEDQEEEEEEEEEEEEEEEDSSSDEETAQLMQPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7V0</accession>
    <name>G0S7V0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0028900</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693346.1">
        <property type="nucleotide sequence ID" value="XM_006693283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7V0"/>
    <dbReference type="GeneID" id="18256928"/>
    <dbReference type="KEGG" id="cthr:CTHT_0028900"/>
    <dbReference type="eggNOG" id="KOG1441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022332_0_2_1"/>
    <dbReference type="OMA" id="VVMIQVM"/>
    <dbReference type="OrthoDB" id="6418713at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="9">
        <location>
            <begin position="29"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS21050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="399" mass="43060" checksum="B1E1C4BCDF23D085" modified="2011-10-19" version="1">MAAENDDIERQAEKLFVAPPARSRGVHAVFYIASWIFFSNLTILFNKWVIDNKGFRYPVILTFWHLLFATIATQILARTTRLLDGRKAVRMTGRTYLRAIVPIGLLYSASLVCSNIVYLYLSVAFIQMLKAAAPVAVLLISWAWGVETPSLRRFMNILVIVAGVALASFGEIDFSWPGFFFQLGGIVFEGLRLVLIQVLLTGDERGSMDPLVSLYYYAPVCAAMNLVVAIASEGAKFDPSDIARAGWGLLLLNAAVAFLLNVSSVFLIGKTSGLVMTLTGILKNILLVVVSVAIWATPISQLQCLGYSIALAGLVYYSLGWDHIIALVGTSVTYARGGYELLSSSSRTEAGHGSASDYPFAVRRGTAMGLAAVLVTILVGGFLFGGSASQIGTGKTWSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0S815</accession>
    <name>G0S815_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0029020</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693358.1">
        <property type="nucleotide sequence ID" value="XM_006693295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S815"/>
    <dbReference type="STRING" id="759272.G0S815"/>
    <dbReference type="GeneID" id="18256940"/>
    <dbReference type="KEGG" id="cthr:CTHT_0029020"/>
    <dbReference type="eggNOG" id="ENOG502SG5B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022723_2_0_1"/>
    <dbReference type="OMA" id="TPYGMPL"/>
    <dbReference type="OrthoDB" id="5421784at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS21062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="569" mass="60076" checksum="F74CA91210B52144" modified="2011-10-19" version="1">MALTSQPHRSDADPNASGPSPSEAPVLAPHHNDDHDFNHNHHFHLRAELRHPHHLHNPHRRLHSDSPTPHARSPSPAPSLSPSPAPSLSPSPSPFSKPSLSEYDDESRDHNLFKRQPVVIIQTVSVVHYIDGSGAVTAVSTLDSLLDSRNPDATASILLETEPAVTHDGVSALAEPLPTVSFSDDILPDLLDDPASTTPTAELEPEVTSSHDLSASLETLTPAPFTSSPESASPTLSTGIFNASSSYHPSLFKNSTAVYFSNHTRTAFKAKTATLTSTRTKSTSSTSARLSSVTPDATSFLDVPVGGNSGAAEGIIPASIDSEHDSDSHSEPGLTPETRNALVGGVVGSIAGIALLALMVLYYIKWRKQHGKGLLLLGDGDSTARGKGPFYGTTLPFINGGGSSGNAEKDETGAQQRTSVWAIPTALAKLTGRRAIEAPSAEPEPQEKGFYRVSGKKLISVLESGGDGYSDPHESVGSASSLYRESRATFLGDEPQAPLKLGSPMRPVSGIPVFRSGPQRVAVQESTALPPGHRPSAYPTALAVVPEAQRASISVTRDGFRVSRFQEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8J8</accession>
    <name>G0S8J8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0038340</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694254.1">
        <property type="nucleotide sequence ID" value="XM_006694191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8J8"/>
    <dbReference type="STRING" id="759272.G0S8J8"/>
    <dbReference type="GeneID" id="18257872"/>
    <dbReference type="KEGG" id="cthr:CTHT_0038340"/>
    <dbReference type="eggNOG" id="ENOG502T9WB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_568575_0_0_1"/>
    <dbReference type="OrthoDB" id="5214702at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS21958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="479" mass="55483" checksum="8FD60270CBB4A951" modified="2011-10-19" version="1">MERQGPFFSARCPTEITLAIFTSCQSLRDVAALIITNRHTAAVWNEHQGHIILHIGRLTIPAFDRALMAARAISIVLWHQMRCKLPPRLHIHELDPSYQKPNPAELAQVLDLHHLARCLEVRYRDPEIILLTLPHDYSQDFQICEDITSAGGTQPEDLGNLEAWREREPLEVIWFRSYGEGGDMPDYGVKPERHGRKYEEVKKGVEELVGYGMNEWLKEKGDHKRAAERILSHPAWLMRVNLGLQEPLFGEFADWFVKVTLKDEARIERAMRPRDGLPRINAKLFNTGPQTWPETSPLGAYFRNGTPEQGRLLFGSVLRAIHMMQIVLLHLEKPEWVGWYVNQLERAKRIHGDNPRPAFPPRKLRATTIIGARDYEPCEVYMDEKPSTRYRVLAENTGSEMLSVQALLLRMNEHRYFLPEQEGKEVWREEGKKIDSFDPTYTLWYFILAREMDVHLVDEPGKQMGAHWGHVQRVGDART</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0S960</accession>
    <name>G0S960_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial genome maintenance protein MGM101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0044670</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
            <location evidence="1">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGM101 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694856.1">
        <property type="nucleotide sequence ID" value="XM_006694793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S960"/>
    <dbReference type="STRING" id="759272.G0S960"/>
    <dbReference type="GeneID" id="18258505"/>
    <dbReference type="KEGG" id="cthr:CTHT_0044670"/>
    <dbReference type="eggNOG" id="ENOG502RXU4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028692_0_4_1"/>
    <dbReference type="OMA" id="QYCHEIW"/>
    <dbReference type="OrthoDB" id="17164at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000262">
        <property type="term" value="C:mitochondrial chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009446">
        <property type="entry name" value="Mgm101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404:SF0">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06420">
        <property type="entry name" value="Mgm101p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="87"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="87"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS19971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="447" mass="48978" checksum="F7F6D974F15281D6" modified="2011-10-19" version="1">MGSQTSKEHQPTVEEPTKAAVEDDDEPDEWEKRIYSTGCAEENAKMTDCYFEKKDWRACKEEIGPFGAGPLHQPRLLFQNFDFISTSSHSSTTNPPSTLLKPPKMSSSRVLQQASRSLQRLRPLSQPQSSLLLQTRAASTTTTSTTARATTPTRSYTARPKPETPAAKAAPATTVITPARTAASTTSKSTTTTNYKSATPTKTNLNTGVIDPQAAIPAATTVADVDPDLAAEMEGGSTPPSASFTQALRESSRVNNGSYMGPGAGTVETIDWSSSFHGLGTMPFDPEIAKVLMAPIDPMDIEIKPDGIIYLPEIKYRRILNNAFGPGGWGLAPRGELVVGEKVVTREYALVVHGRFIAQARGECQYFSEETIPTAGEGCKSNALLRCCKDLGIASELWDPRFIREFKKQYCHEIWVEHVVTKKRRQIWCRKDGEPAYPFQAVKPMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0S986</accession>
    <name>G0S986_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0044940</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694882.1">
        <property type="nucleotide sequence ID" value="XM_006694819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S986"/>
    <dbReference type="GeneID" id="18258532"/>
    <dbReference type="KEGG" id="cthr:CTHT_0044940"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_1_1"/>
    <dbReference type="OMA" id="VLWGMGW"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF193">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G00940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="497"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="572"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="106"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="604"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS19997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="632" mass="66922" checksum="78F812974D12FE25" modified="2011-10-19" version="1">MAASQHSTPRLGSSSSSVYRPSDGDSSPVYSLGSIGITVPSSPVFRPFDAGTDGDSEIIELQTVPLQDPTPAPLNTEPDIGRDGAASIRDESPSPPYAMGFKLFAMLASITTAIFLMMLDTSIISTAVPRITDEFHSVDDVGWYASIYSLASSAFQPITGRIYSKFNIKYSFLAFFAIFEAGSLICGTSISSGMFIIGRAVAGAGSSGFINGAVTILAATVPLEKRPSLTGIMMGFSQLGIVLGPLVGGAFTSYTTWRWCFYVNLPVGAIVAIGLMLVDIPDLVTKPKPFDVLRRLHVELDLVGFTLIAPAAVMLLLATQWGGDPYAWNSPTIIGLFCGAGASAVVWFVWNFYHGEDALIPMSILRINATWSSACTQGFLLTGVYCASFYLPMYFQAVKGVVPMMSGVYLIASIGSQLLSAVVAGMLVERTGYVIPYAMLSGIIGSVSNGLYSTFKPDTATSKWVGYQVLNGVGRGFGMQMPVLAVQAALRPPQIPIGLSVVSFIQSLCVAIALAVSGTIFDLTLVHDLTQRAPDVDPNSILDAGATNFRSIVAPKDLPVVLQSYNIAISHVFYMAAGITGLAVFTSLFMGWIDIRKTHGSLSANGPRTGDAAGGNGQQAQQQHVDGPKHDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0S996</accession>
    <name>G0S996_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Multicopper oxidase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0045040</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694892.1">
        <property type="nucleotide sequence ID" value="XM_006694829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S996"/>
    <dbReference type="SMR" id="G0S996"/>
    <dbReference type="STRING" id="759272.G0S996"/>
    <dbReference type="GeneID" id="18258542"/>
    <dbReference type="KEGG" id="cthr:CTHT_0045040"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006504_8_3_1"/>
    <dbReference type="OMA" id="QWPIAPH"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13873">
        <property type="entry name" value="CuRO_2_AAO_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017762">
        <property type="entry name" value="Multicopper_oxidase_fun"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03390">
        <property type="entry name" value="ascorbOXfungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF394">
        <property type="entry name" value="FI03373P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="36"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="5">
        <location>
            <begin position="157"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="451"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS20007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="633" mass="71531" checksum="2D4FAA0BC1E49DAE" modified="2011-10-19" version="1">MLPIRARTSEDVATGEVVHGADFVPDFILRVSVAWVESSCEGRQNIVINGTSPGPAIYLRPGSSPWIRVYNDIPDQNLTMHWHGIAQRLAPFADGTAMISQWPIPPGHYFDYQIALEPDDAGTYFYHSHVEMQALSASGPLIVDDCASLPYHYDDERIFHFMDHFSKSDEEIVEDLTSSPYNFPGESKGVLLNGKGIAVGYTPSPGPPGGPNGFFGLRVGNHPACVAPSEPEPVEFQPGMDQIEQTSDCTLPVIDVEPGKMYRFRFIGATGLSYIAIAFEGHETLSIIQTDGTEYNEPVVTDHIQLAAGQRFDVLFKTKSLEELQKEGRNFYYIQYETLHRSDTYRGYAVLRYDYDAEVPTPPAAPIRAFSAAEVTSWGEYSFRPLYPERNQAPSADEVTRRLIITCEEKEDFKTGRVIWELNRLSWTEERRQIPVLVDIYNRGQDAIPNYEVALHNYGWDPVTKLFPAKVGEVIEIIWQNTGSQFFTITGLVESHPFHAHGQHYYDIGAGPGYYDPEVNNKKLEETGFRSVKRDTTMLFRYQDKVKPGQAAGWRGWRIRIDHPGVWMLHCHILTHMMMGMNTVWVIGDADDILTIPLSISQHYLKYGGDVYGNITHAPVVYHFFNQTSKCIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9J0</accession>
    <name>G0S9J0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0046060</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694986.1">
        <property type="nucleotide sequence ID" value="XM_006694923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9J0"/>
    <dbReference type="GeneID" id="18258644"/>
    <dbReference type="KEGG" id="cthr:CTHT_0046060"/>
    <dbReference type="HOGENOM" id="CLU_801677_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="346" mass="38239" checksum="B2B91BCD98E197B4" modified="2011-10-19" version="1">MHHLTGSQDKVNFEAAEKYSATGSRHRGRLFGSKKGNHPERKVTNGPFLHELPPAALNDANVSVSSHDVDDEVVTKHGVEWVDPDWKVTSCLFPHERPVVKANDNDNVVSIANKGYDTQSLVGAGKDNEKIVRPIAIPSRIMAHPDWEMSDSLFPHELETIPKHHKSTSSVSSDGVKSTHFLFPHELPTIPSDRIMPSNGTDAVKGTHFLSPHDIPAWFNHSANSSLSNMSEAGYSHSHHGSVHSNHDEGHLAARPLIEIHNVTDLVNAINNPTAGGSISRTSSISSSIRRERSLLFASWDGVWRFPGLAESEQGDYFVRDEEEEDNDEEDGDDDVLQLVVRKDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9N8</accession>
    <name>G0S9N8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0046560</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695034.1">
        <property type="nucleotide sequence ID" value="XM_006694971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9N8"/>
    <dbReference type="GeneID" id="18258694"/>
    <dbReference type="KEGG" id="cthr:CTHT_0046560"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1053757_0_0_1"/>
    <dbReference type="OrthoDB" id="268400at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="264" mass="28621" checksum="9400F275873E9128" modified="2011-10-19" version="1">MGYQGSLCFSDFKAISGGSATGVNPFAIIPPEVVPAGVEKMSMLATVPLLSNGIAGRRPVLILAGACAWTGGLIAATSSSLETQLASRAMQRNKAIAAVVSSQGNIIIGLGTVTPYSASNYDWRWIYYITSGAGIIAWILLLIFLPETRWKRSKEELNMVIALPQSLLITKLSSPGGQQLYPVTPGKDRLDLDYTTYFAPTTWTYIGLFQHDLKWKEAGLSMLNTLRITLFPVIIWATITNSIFVIVHSAAQQISSLPSLLRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9S1</accession>
    <name>G0S9S1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyl transferase family 25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0046940</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 25 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695067.1">
        <property type="nucleotide sequence ID" value="XM_006695004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9S1"/>
    <dbReference type="GeneID" id="18258732"/>
    <dbReference type="KEGG" id="cthr:CTHT_0046940"/>
    <dbReference type="eggNOG" id="ENOG502S152">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_318311_0_0_1"/>
    <dbReference type="OrthoDB" id="47375at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06532">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050757">
        <property type="entry name" value="Collagen_mod_GT25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002654">
        <property type="entry name" value="Glyco_trans_25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730:SF53">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730">
        <property type="entry name" value="PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01755">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 25" evidence="5">
        <location>
            <begin position="539"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="361"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="806"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="892"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="369"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="904"/>
            <end position="914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS20182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="914" mass="101280" checksum="EDB45ACE61C71461" modified="2011-10-19" version="1">MMASAQFYNLLLVPSNDQSSPLAVCFATLCSTQEQEAINSTIRINGATTPLNRLSNEHIKRRVSARLCLLNECTKRLISGWARRIRLSEKNDLLESSVDALVKAKLIAPGRTLLHIWQTHYDGHHKHRAVEFNYVTDAVVLTDPDGDGKGAVRIQQMKQAAGSESLAARTGTSGLRRSAPMRAVIACCTTISGAYCSPAGSKERADDRLLSGAMPACKKCAGCCRAWPFYNDGGEQEDVDAVRARLLRECLVKKVRLFKEMIQDITWEHALGFLSPDEGPAPAPPAPSTSMVLSRLALDQLTADDNDAISLCGEDILAEDDQAWYNNSIEYLAIEQHTDTLGELYDDWFVVQLGEPAAYFRSTRDHSDNNQNDNANYNNTGTAANVSSPSPYPDPPRTNFSEEYLITLTGLIGEELGPIVEETFMSPYFFWWRPSTAVMSAYCSFHCPPTSGTCKPCSFVDYKLELRPELGQPPARNIRMERWVEGRVSVDVLDAKDGDVWVKTGCAEGGVDAYEFVQSVLVAWTLLGNPVNRIELPFQRIYAINLPSRTDRRDILTLAAAFTGIDITWVDGVKGEDVSEKALPGKEGAKVLPIGNIGSWRAHMNVLQRIVQENVTTALIFEDDVDWDIRLKSQLQLFALAATAFTTPSSPGPHTMASFHRLTHDNLSVPITQLPPAPNPHANPYGPPSDWDVLWLGHCGTSLPKGPSPNPKVPPHLRITIPHDETVPPPKHMRPHPFARQDPWTGEYPPHTRLVHAAHNMTCTQAYAVSQRGARRLLWRFGVVEGLGRGLGWDLVLGEWCDGVEPDDHKLDSGNEGEKKNKEEREEQVYELKGRERVCVTASPPLFGHVYGGESDIMAAGGGLLRGKKEVVPYVRWSVRLNLGRLVEGGEVKDQWGEEEEGSKDDKRGREERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9T9</accession>
    <name>G0S9T9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7702 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0047150</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695085.1">
        <property type="nucleotide sequence ID" value="XM_006695022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9T9"/>
    <dbReference type="STRING" id="759272.G0S9T9"/>
    <dbReference type="GeneID" id="18258753"/>
    <dbReference type="KEGG" id="cthr:CTHT_0047150"/>
    <dbReference type="eggNOG" id="ENOG502S0ZE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024263_0_1_1"/>
    <dbReference type="OMA" id="CHPTNIR"/>
    <dbReference type="OrthoDB" id="3357002at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021460">
        <property type="entry name" value="DUF3112"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056119">
        <property type="entry name" value="DUF7702"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35184:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35184">
        <property type="entry name" value="YALI0C10208P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11309">
        <property type="entry name" value="DUF3112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24800">
        <property type="entry name" value="DUF7702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7702" evidence="3">
        <location>
            <begin position="65"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS20200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="352" mass="38538" checksum="E6EFE431C6124005" modified="2011-10-19" version="1">MASITQGLMPLLPRGGPYPPSGAQLGGIPTKKVDVPTSAVLLALFFAGAATHMTVFQVNRRRGHFFIFSVLVFGFCMARIMGLVMRIAWACNPTNIDLAIAAQVFTNAGVLVLFIVNVFLLVRIVRGEAPKVGWSRPVWVALRALVVSIIAMLVMVVTCSVHSMFTLNMETRQKERKVLLFAGVYMSVIAFLPMLVIPILLLLKTIAKKNIDLGEREDFGTPDVAGRIRTKITLLFVASVLLTIGAGFRVGVNFATRPAFNPAWWHHKAAFYCFSFALELPVVYMYALFRFDKLFWVPDKSSKPGDFSRGVVAADDCDQEDEVLEEGGKSGNSGATSTREKENGGKSDAQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9U8</accession>
    <name>G0S9U8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Trafficking protein particle complex subunit BET3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0047240</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Golgi apparatus</location>
            <location evidence="1 8">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695094.1">
        <property type="nucleotide sequence ID" value="XM_006695031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9U8"/>
    <dbReference type="STRING" id="759272.G0S9U8"/>
    <dbReference type="GeneID" id="18258762"/>
    <dbReference type="KEGG" id="cthr:CTHT_0047240"/>
    <dbReference type="eggNOG" id="KOG3330">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087110_0_0_1"/>
    <dbReference type="OMA" id="MVQMQVQ"/>
    <dbReference type="OrthoDB" id="10262857at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14942">
        <property type="entry name" value="TRAPPC3_bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000001">
        <property type="entry name" value="Trafficking protein particle complex subunit BET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016721">
        <property type="entry name" value="Bet3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13048">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018293">
        <property type="entry name" value="TRAPP_I_complex_Bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR018293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS20209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="189" mass="21597" checksum="01C38459E5A0D823" modified="2011-10-19" version="1">MSSSKASRLGEETRMDKVNAELVVLTYGTIVAQLCKDYDYDYIEVNKQLDKMGYNIGLRLIEDYLAKSNTVRRCANFRETAEMIAKVGFKIFLNITPTITNWTSDGKQFSLVFDENPLADFVELPDDGRAQDELWYSNILCGVIRGALEMVQMQVEAHFVSDVLRGNDTTEMRISLIRYIDDELPPEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0SA33</accession>
    <name>G0SA33_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative specific RNA polymerase II transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0040840</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694490.1">
        <property type="nucleotide sequence ID" value="XM_006694427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SA33"/>
    <dbReference type="STRING" id="759272.G0SA33"/>
    <dbReference type="GeneID" id="18258122"/>
    <dbReference type="KEGG" id="cthr:CTHT_0040840"/>
    <dbReference type="eggNOG" id="ENOG502QQXX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006632_1_2_1"/>
    <dbReference type="OMA" id="HIFAFNW"/>
    <dbReference type="OrthoDB" id="2264294at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN DAL81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="334"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="540"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="719"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="548"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="719"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="741"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS19605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="785" mass="86490" checksum="4F040C75373E9153" modified="2011-10-19" version="1">MSTPCAVPRTAPIAIAPKPPRFPPSRQGSVHLDSHPGLRNGFDSPGSDSVNSHLFHPCEACFRNRNECVMSEEGESCVACLVAGTECSWAESPPLRKRKLNGDLEDNSSKRSSPGRSDFRRRRHQQQSLSCATTTSSLIEDMANFGGPTLLKRTLGLQEDRYSQYIGPTTDFEPSLINLSNFDTHDESLLARGTLRRVSDEDTFLLLPDSATPGYHRILEDADEIERIVAPNGRKLIDLYFKIVHPAFPILQKNVFYEKYERSYREFSPPLLAAIYLLAINWWDHCEELAGQPKPNVRELERLVRTSLADAMYRPKLSTIQAGLILSQRPEGDQWAPTGQLVAIGQELGLHLDCTHWKIPPWERGLRKRLAWALYMQDKWGALVHGRPSHIFASNWAVQQLTPNDFPEVEWDENNMEERMEIERGRAVFGQMVQLSQILAEILETFYTLQASQAVAAAGPQGTQLVLSLAKPIQLKLKEWYSGLPAIVRMEPSIHQSMQQPGKFSPIGYLHLAYFATEITLHRRIIRSMESSAQAARAAAQSGASNATTNGAGTKTSQYSASPAGSNLGNPYPPCGIDPYVQHICRSAAKARLISAMDFVNRLTPAHLRAFWYFASKTNFALIGTFGSLLWATSPGREEADWYRRRLGEYRWTLSVSSKPGEGKGLTEFAMGMLDISTGLLKQLPEKPSLSRSNSAVDLDMVRRQSMLALGAASPAAALPGRSSSMASMSGLSTHGGSAGSRFQQSSAEGSGVQSPRSPESDESDDDDGVYGNFSATAGMAGIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0SA59</accession>
    <name>G0SA59_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0041100</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694516.1">
        <property type="nucleotide sequence ID" value="XM_006694453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SA59"/>
    <dbReference type="STRING" id="759272.G0SA59"/>
    <dbReference type="GeneID" id="18258148"/>
    <dbReference type="KEGG" id="cthr:CTHT_0041100"/>
    <dbReference type="eggNOG" id="ENOG502S3XI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039527_0_0_1"/>
    <dbReference type="OMA" id="DHHWDEM"/>
    <dbReference type="OrthoDB" id="5407351at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.230">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="367"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="295"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS19631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="400" mass="42930" checksum="653BE7EA7DBB147C" modified="2011-10-19" version="1">MADSMCGPSNGAKNLLAHVDRDRTLHQDRLVNGAQAGPGSVSRASHTHPSARSPDLVRSGGHGLLTLLLLFVFQTFRSQGPISHGSDAAFANFQQGIAPMEPAMLPAMDMNALHHTASVRPVGPAGIAHHGPSTPAARLSQPATGGASHQDWVGQFHNMNLSAPTVAGPSTAMPAPATAAPLAQTMAMPPTMATPFGMPMFSPAPDFAFQQQAPAVQDPIEAALMNDDAFARAFEEYEQVAKEDDELAKALAEEKQKIANAEFIEAQDQWMAEHGPRAEQARSGAKTGPPTADEMEVIDHNLEELAREQEEKRRNDEELARAANEIVASVAGNQSEKFKKSKFFELMRRIAAHEVVVQGDNFVETATGETVNNEYPYEENEPEEYREGTSGANGAARPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAF9</accession>
    <name>G0SAF9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11 12">Endo-1,4-beta-xylanase</fullName>
            <ecNumber evidence="4 11 12">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CTHT_0042130</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11 12">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 12">Belongs to the glycosyl hydrolase 11 (cellulase G) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="4 11 12"/>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694616.1">
        <property type="nucleotide sequence ID" value="XM_006694553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAF9"/>
    <dbReference type="GeneID" id="18258251"/>
    <dbReference type="KEGG" id="cthr:CTHT_0042130"/>
    <dbReference type="eggNOG" id="ENOG502RXA7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052631_0_1_1"/>
    <dbReference type="OMA" id="PLECNGF"/>
    <dbReference type="OrthoDB" id="2115822at2759"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018208">
        <property type="entry name" value="GH11_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033123">
        <property type="entry name" value="GH11_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001137">
        <property type="entry name" value="Glyco_hydro_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828:SF3">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00457">
        <property type="entry name" value="Glyco_hydro_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00911">
        <property type="entry name" value="GLHYDRLASE11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00776">
        <property type="entry name" value="GH11_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51761">
        <property type="entry name" value="GH11_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11 12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11 12" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409077" description="Endo-1,4-beta-xylanase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="GH11" evidence="15">
        <location>
            <begin position="28"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="14">
        <location>
            <begin position="233"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGS19731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="269" mass="28269" checksum="6DB295F2B0D3E2FC" modified="2011-10-19" version="1">MVNFSTLFLAASTAALAAAAPSIEKRQTLTSSATGIHNGYYYSFWTDGQGNIRFNLESGGQYSVTWSGNGNWVGGKGRPNGNSYLAVYGWTRNPLIEYYVVESFGTYDPSTGATRMGSVTTDGGTYNIYRSQRVNAPSIEGTSTFYQYWSVRTAKRTGGTVTMANHFNAWRQAGLQLGTHDYQIVATEGYYSSGSATVNVGGSATGGGNNGGGNNGGGNNGGGNNGGGNGGANCSPRWGQCGGQGWTGPTCCQSGSTCRFQNNWYSQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAG6</accession>
    <name>G0SAG6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0042210</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694623.1">
        <property type="nucleotide sequence ID" value="XM_006694560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAG6"/>
    <dbReference type="STRING" id="759272.G0SAG6"/>
    <dbReference type="GeneID" id="18258259"/>
    <dbReference type="KEGG" id="cthr:CTHT_0042210"/>
    <dbReference type="eggNOG" id="ENOG502SUGA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_546275_0_0_1"/>
    <dbReference type="OrthoDB" id="4587586at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS19738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="499" mass="58416" checksum="C46B790EDC4E7A90" modified="2011-10-19" version="1">MSEIRDTETSAYQELMQSGGRPMYPICLLDEVLKDPEGHLSFLLPWQAYPGTGIPDRNVFTKQLARWKAFRSWQKDCRGIRTDEKEFDAYVEDTKRRDPEWRGELNYEHQELMDQHLRRLQAEFEKTPEAKDSNDKGAAFREFVEKRRQRNLEVGCTWPGMTEAEYRQALSVQFNLDKYRRYQAHLGLLALARGKHGFPEYVAKARRRLSEFGLTQTFEFDEDPTRQDKLTTWIKYLYYELLWHDYHERSINRMQREYDEAWEKLVASRVLQSMETDETLRTTESILQRASERQHAEQALAAAEEAARKALLETAKAIHGGSSLSLQQRKQRLKTAYTGLLKAKKTLKIITRRNNLIAEFLQKTRGYSEAKYNLQRQQLLLQWILAQVPHVEEEVNAFNGNNTITSGLDHTHRKKRHPSTSIEDIGIFAHRSNEPWDERPAKRIRINNQGGALGNEDVQLRRSARIAARRSHCLEDKKQASICLRRSARLAAKRSLQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAM0</accession>
    <name>G0SAM0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GDS1 winged helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0042760</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694677.1">
        <property type="nucleotide sequence ID" value="XM_006694614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAM0"/>
    <dbReference type="GeneID" id="18258314"/>
    <dbReference type="KEGG" id="cthr:CTHT_0042760"/>
    <dbReference type="eggNOG" id="ENOG502S2UH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036462_0_0_1"/>
    <dbReference type="OMA" id="VGTHPKR"/>
    <dbReference type="OrthoDB" id="4150221at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057511">
        <property type="entry name" value="WH_GDS1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25318">
        <property type="entry name" value="WHD_GDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDS1 winged helix" evidence="2">
        <location>
            <begin position="125"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS19792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="453" mass="49096" checksum="AB050A6F4556D933" modified="2011-10-19" version="1">MRPYNTRHKTLSLHSLGIHVPGSGPARAATASRTSPASSCHSHSNHSNSSASSLTPKDDQPPAKRQKRAHSESSDTAPALDRLPKKRDDVAANRKYENTPPPSPPADVERPSIETDDTPAPRPIDMSSINDEIVEAVIVQLQKSRNRPHLVKELATILMPQLKIVQQSANPCAIISSRLSAFLKRPGWSTDSPCPLAKELESVHPRRTYFYLTTCPRQPLPDPAQATSVPSRSIISPSPSSSSADDSSDDLERRRELSPSPEVDLSSPELDDIDDDFTMPGTPIGSFTMRGGYYMPSRHHQSGSNRIHIHRSASPPLEKDEKEFTQTADGLQKRKLNGDNMSSLLDVQGPPSAGATGSSIMIDLERDDPFGVASIPPPSSSTNFLLSSPAIRPASAAAASSNVSSVSFGKKDSDMMIMSGVDGSWARLDGMLEWDRSPESIELEELDGLLDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAS2</accession>
    <name>G0SAS2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Smr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0043290</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694729.1">
        <property type="nucleotide sequence ID" value="XM_006694666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAS2"/>
    <dbReference type="STRING" id="759272.G0SAS2"/>
    <dbReference type="GeneID" id="18258367"/>
    <dbReference type="KEGG" id="cthr:CTHT_0043290"/>
    <dbReference type="eggNOG" id="KOG2401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023589_0_0_1"/>
    <dbReference type="OMA" id="KERVWRW"/>
    <dbReference type="OrthoDB" id="4080456at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052772">
        <property type="entry name" value="Endo/PolyKinase_Domain-Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535:SF1">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="2">
        <location>
            <begin position="356"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS19844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="449" mass="47711" checksum="30B049DCEC597059" modified="2011-10-19" version="1">MTAKTDTTAGDIAEQNRRMLVEEFGSVLDESLILALSGDRDIVKELDAIRADLRLLAETASAEAATGFDPSGSGGGLADSLEGLRLDESTTNASGDGVSTTDWLVPENSTSVSDYSDLSDLSSQPQLALTDQSELTDEQKLQTLHLVFPGQFKDHTLQIVLRENNGDIVGTIEDLLSRAAINEEGARPKGIDGFVQEEYTRANGSGSRGTKKAKGKSSKNANKLTISYKAVSSTGQDEELQGAADFLPSPARPARRLPPQPRPPPVSTSSISFSTPTSPTIMSPISPALPPCPSSDMINHSASQASSLLRGRAGPLGRQGAVVYTERLREALSLQRAHISREADAIVAKNSTKTSVDLHGVNVADGVRIADQRLRAWWDAICNDESSARRGGAKRTVREGGGGFTVITGQGKHSKGGVSPMRQTVGAYLRNNGWRFEVLTGGFLVTGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAZ3</accession>
    <name>G0SAZ3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy-related protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CTHT_0048320</name>
    </gene>
    <organism evidence="24">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(out)</text>
            <dbReference type="Rhea" id="RHEA:67920"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)</text>
            <dbReference type="Rhea" id="RHEA:38571"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Preautophagosomal structure membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATG9 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695195.1">
        <property type="nucleotide sequence ID" value="XM_006695132.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0SAZ3"/>
    <dbReference type="GeneID" id="18258870"/>
    <dbReference type="KEGG" id="cthr:CTHT_0048320"/>
    <dbReference type="eggNOG" id="KOG0760">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2173">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006200_4_0_1"/>
    <dbReference type="OMA" id="SMWETSP"/>
    <dbReference type="OrthoDB" id="2020634at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000029">
        <property type="entry name" value="Solute carrier family 25 member 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007241">
        <property type="entry name" value="Autophagy-rel_prot_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13038">
        <property type="entry name" value="APG9 AUTOPHAGY 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13038:SF10">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04109">
        <property type="entry name" value="ATG9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0072">Autophagy</keyword>
    <keyword evidence="15" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="14 20 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 20 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="413"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="20">
        <location>
            <begin position="1025"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="20">
        <location>
            <begin position="1120"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="20">
        <location>
            <begin position="1213"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="743"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="772"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="794"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00024621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00024631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EGS19373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1311" mass="146049" checksum="28C69A1288156420" modified="2011-10-19" version="1">MASNPFSRAFPPAQGRSFFGESSRRDDDVESRAALLDEENLRHQFNDYDLEHAEGLEVDDSRPSLGGAASPPPSRPRRGPTHRPTRASTSKSTWAPHDDDGDNDVPPSLLVEAHDGSSGRGPGQPRKVSRGHQGTAIPGPSTPRAHWDAAHTPPRQRANNPPASHHHGVSLPTSLFSGSISGSAKKRAEWRWANVTNLDLFIKDVYDYYLGHGIWCILTDRFLHLVNVAFVAVLLTFLTQCVDYSKVRGSQKLSQILVPQCTRNMSGLWNTGLFMFAFYFIWKLIQYLLDMRRLLHVRDFYIYLLNIPDDDMQTITWQEVVARIMALRDQNPKTATNLTPEQRQWLGSQSKERLDASDIANRLMRPPTPFKNARMDDNFAILDFVFDERGQVNPVFLRSERRHELSMKLRRRFAFSGILILVLSPFIAGYLVVVYFLMYYHEVQKNPSVLSSRTYTPLAEWKFREFNELPHLFRERLNMSHPYAIHYIDQFPKAKTEMVARTVAFVSGALATVLAICSVIDPDLFLGFEITHDRTVLFYTAVFGSVWAFARGMISEDHLVFNPELAMRNVIQYTHYNPDHWEGRLHSADIKAEFSELYKMKVIIFIEEILSILTTPFVLLSSLPKCSDQIIDFFREFTIHVDGLGYVCSFAEFDFKNGFGKKKAKEGTGDVRDDYYSTKHGKMEASYYGFLGNYGNFVLDPKKGTGSHFPHGSRFFHPPPVWPGINEPDLQTSRMGRSRMLPRTGTGLHQPSPMASILLDPHHQPPAGTNFGARARSQQPQQQRGAGHQRESNIMEEPDEEDNDEDKRQDDEEAFEGGVALDESAWQTSPARTLNREDTAMSAPHAGVVHMIYQFNQAQLNRRPGGVRIFDQHQLEVVVHCPLHFPNCERRQSDAVLVTNSTEARSSVDSSARAPVAPGLRFCGTANQKNPEASFASRCVHVLRHLVASAVAAAAQELPPGPTTRTTAAAAAFTALPLPRRRVSDALTFNLALNVGATGAVASTMAQPNAEPVEEYDYESLPPNFSLVQNMAAGAFAGIAEHCAMYPVDAIKTRMQVATAVSAPRGVIQATYRMATTEGILSLWRGMSSVIVGAGPAHAVYFATYEAVKHLMGGNQAGVHHPLAAATSGACATIASDALMNPFDVIKQRMQIANSSKMYRSMLDCARYVYRKEGLAAFYVSYPTTLSMTVPFTALQFLAYESISTHLNPTKKYDPLTHCLAGAVAGGFAAALTTPMDVIKTMLQTRGTATDAELRTVSGFTAGCRLLYKREGFRGFFKGVKPRVLTTMPSTAICWSAYEASKAYFIHQNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0SB00</accession>
    <name>G0SB00_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1917-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0048390</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0696 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695202.1">
        <property type="nucleotide sequence ID" value="XM_006695139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SB00"/>
    <dbReference type="GeneID" id="18258877"/>
    <dbReference type="KEGG" id="cthr:CTHT_0048390"/>
    <dbReference type="eggNOG" id="ENOG502SG47">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051869_0_2_1"/>
    <dbReference type="OMA" id="RPIYYKC"/>
    <dbReference type="OrthoDB" id="10067381at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015034">
        <property type="entry name" value="Bles03"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31977">
        <property type="entry name" value="UPF0696 PROTEIN C11ORF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31977:SF1">
        <property type="entry name" value="UPF0696 PROTEIN C11ORF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08939">
        <property type="entry name" value="Bles03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS19380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="36291" checksum="FB7D70FB5B8A0A6E" modified="2011-10-19" version="1">MDSDSDFYGATPPTTKPSSPQPTNTIPGDEETITALQRRVSSFDPLAWWARNGHLTPSQSTPTKPSPSSQPSQPSSSLHNPYAGLPNAWQLHEPISDFLSRLPPSTTDWRPGLEWIFVANPHTASRYHAPGALQLFRRGGQERLKLFEKFQDMAIKALQQDDSSLSSSGRGKPPDLTVVQREVEREKKETVQDLTELAVECGILAGKWMLFPEENDVDEVWRKVVQATVAGELGIAAKVETKIDKGKPRLICIYTKDFRDKEDVARVLEGLRGLGLVKSGKQIYYKSEAWTELNIYSGNTWGIQASLYSSGQILSYLRAKRPRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0SB81</accession>
    <name>G0SB81_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0049220</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695283.1">
        <property type="nucleotide sequence ID" value="XM_006695220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SB81"/>
    <dbReference type="STRING" id="759272.G0SB81"/>
    <dbReference type="GeneID" id="18258960"/>
    <dbReference type="KEGG" id="cthr:CTHT_0049220"/>
    <dbReference type="eggNOG" id="KOG1167">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_118_2_1"/>
    <dbReference type="OMA" id="QGFTMEK"/>
    <dbReference type="OrthoDB" id="10020333at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14019">
        <property type="entry name" value="STKc_Cdc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF23">
        <property type="entry name" value="CDC7 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="95"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="34"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS19461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="481" mass="54718" checksum="380D18D4113B273B" modified="2011-10-19" version="1">MESVVPGRGHRDQPFTIHEDAPSTADTEMLESASPEDDDNVEQMDDMADDMEGADDEDQESDYSASSDDEVVEDPYVLQDMEKLQNSFPGFREKYRLIKRIGEGTFSTVYKAEDLLYDDYDNSWDLDRDNDRYAPPPLRSGDGAEAQPSRRRKPKYVAVKKIYVTSSPSRIFNELDLLHDLRGCKAVCPLITAFRSADQVIAILPYFRHADFRDYFRDMTVTDMAIYLRSLFTALASVHSHNIIHRDIKPTNFLYNPATRRGVLVDFGLAEREGYDCKPCVCHEPMARRMKRAAVKKLAAMPRKGGYPRDDTRPSRRANRAGTRGFRAPEVLFKCTEQTTKIDIWSAGVILLTILSKRFPFFNSADDVEAMIEIATIFGWHRMQQTAALHGCMFETTIPTIGKSGFSFEAIILWSTNRSGKELPEDEQLAVEFLKRCMELDPSKRISAEEALRHEFLQLGLEQEAEGKGETGDDELDILKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBH2</accession>
    <name>G0SBH2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0050260</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695374.1">
        <property type="nucleotide sequence ID" value="XM_006695311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBH2"/>
    <dbReference type="GeneID" id="18259064"/>
    <dbReference type="KEGG" id="cthr:CTHT_0050260"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_488317_0_0_1"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF73">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409460" description="Peptidase A1 domain-containing protein" evidence="4">
        <location>
            <begin position="25"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="5">
        <location>
            <begin position="45"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="511"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="535"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS19552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="558" mass="61568" checksum="4BE39CEE15D17BC4" modified="2011-10-19" version="1">MSSKFSLSTVAVCFLGAAFAAAHAKRSDDFTPLQLPLTSLPEWTHVVNVTIGTPGQSLPMIISTIHYHTWVPNADSKYCDAAGYHENKLDNGHHNIKPFPSVCRWGSFNSSLSKTYVDRTPNDQNTAWFQWFHEISEGVLEDNGGNINGMNFTDRLEAGDIVMDDYPMVLQHSGRRWIGVLGLKNRTGWLLEEGYPSFMERLVSSGRIPTNAFSVWLDNPEGTTGSVLFGAIDKSRYEGKLTRMVVGNSYNIYITSFSGIMESGEKLTPPPDPNLADPEGKRSYIAILTISNRFSYLPPFIADWMAEIVGARYNETLQRFTVPCDAGQSKKAKFSLQLEGEKGPVLTVEVSDLIIPVTDIIPLYSHHINDTGTYYSEDLRGNNTCFFGVQKDSEPWFYRIGSSLLRHTYMVFDNVNGEVGFAPVKFPSPDAEPPAPEIVYFKNYGATIPSSKIYCGASKNECIRAGYKLDQTRRNVGIAFGVIGGVLLVALLGWCFWKLYKRSKATAAAAAARDEETVAEDGSRSLITKVQSGQETEAPAATESSSSVAGQENRAARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBQ7</accession>
    <name>G0SBQ7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CTHT_0054430</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2016" name="Acta Crystallogr. F Struct. Biol. Commun." volume="72" first="409" last="416">
            <title>Structural analysis of the spliceosomal RNA helicase Prp28 from the thermophilic eukaryote Chaetomium thermophilum.</title>
            <authorList>
                <person name="Tauchert M.J."/>
                <person name="Ficner R."/>
            </authorList>
            <dbReference type="PubMed" id="27139834"/>
            <dbReference type="DOI" id="10.1107/s2053230x16006038"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (3.20 ANGSTROMS) OF 238-709 IN COMPLEX WITH ADP</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the U5 snRNP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695778.1">
        <property type="nucleotide sequence ID" value="XM_006695715.1"/>
    </dbReference>
    <dbReference type="PDB" id="5DTU">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="A=238-709"/>
    </dbReference>
    <dbReference type="PDBsum" id="5DTU"/>
    <dbReference type="AlphaFoldDB" id="G0SBQ7"/>
    <dbReference type="SMR" id="G0SBQ7"/>
    <dbReference type="STRING" id="759272.G0SBQ7"/>
    <dbReference type="GeneID" id="18259481"/>
    <dbReference type="KEGG" id="cthr:CTHT_0054430"/>
    <dbReference type="eggNOG" id="KOG0333">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_11_3_1"/>
    <dbReference type="OMA" id="ARDIKHM"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="BRENDA" id="3.6.1.B17">
        <property type="organism ID" value="1279"/>
    </dbReference>
    <dbReference type="BRENDA" id="3.6.4.13">
        <property type="organism ID" value="1279"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17945">
        <property type="entry name" value="DEADc_DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000322">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057479">
        <property type="entry name" value="PRP28/DDX23-like_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25430">
        <property type="entry name" value="DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="21" id="KW-0002">3D-structure</keyword>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4 14 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="18">
        <location>
            <begin position="276"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="307"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="521"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="21"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="678"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="276"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="22"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="106"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGS18833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="21">
        <source>
            <dbReference type="PDB" id="5DTU"/>
        </source>
    </evidence>
    <sequence length="709" mass="80264" checksum="CAF2714613F29AFD" modified="2011-10-19" version="1">MGTEPTNRRVPPDVAALLRKRKAEEELASKPRFIPKKERERLEAEKKAKEEEARRRQEEELKKKEEEFQRAIKNGLSGTNGANGMDGIDNKAKSQRDIPTGPKAMRHGEGGKRGRTNEEEQKRAEMERNDEAELRARYMGPEVNQSTFSVKKKRRRTATQKFNFDWDPDDDTSRPFDPIYAERPDPLFRMAGYEMDDELVLRKAEAIRRGDPETGEERARKLLEQHQRVKQLKEQKNLGKHWSEKKLEEMKERDWRIFKENFGISTKGGSIPNPMRNWEESGLPRRLLDIVYRVGYDEPTPIQRAAIPIALQARDLIGVAVTGSGKTAAFLLPLLVYISELPPLTEYNKNDGPYALILAPTRELVQQIESEARKFADPLGFTVVSIVGGHSLEEQAFALRNGAEIIVATPGRLVDCIERRLLVFSQCCYVIMDEADRMIDQGFEEPLTKILDALPVSNEKPDTEDAENPQLMSRYLGGRDRYRQTMMYTATMPPTVEKIAKKYLRRPAIVTIGNAGEAVDTVEQRVEFIAGEDKRKRRLQEILNSGQFKPPIIVFVNIKRNCEMVAKDIKSWGFSTVTLHGSKTQEQREASLAALRNGQAHILVATDLAGRGIDVPDVSLVVNFNMPSTIEAYTHRIGRTGRAGKSGVAITFLGNEDADVMYDLKQIISKSSISKVPEELRRHEAAQSKPNRVKKIEDSSGFAGKGGWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBR9</accession>
    <name>G0SBR9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fibroin-3 related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0054560</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695790.1">
        <property type="nucleotide sequence ID" value="XM_006695727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBR9"/>
    <dbReference type="STRING" id="759272.G0SBR9"/>
    <dbReference type="GeneID" id="18259494"/>
    <dbReference type="KEGG" id="cthr:CTHT_0054560"/>
    <dbReference type="eggNOG" id="ENOG502SAKR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022094_0_0_1"/>
    <dbReference type="OMA" id="HDQGYGA"/>
    <dbReference type="OrthoDB" id="5401332at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037504">
        <property type="entry name" value="PSI_induc_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40018">
        <property type="entry name" value="[PSI+] INDUCTION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40018:SF1">
        <property type="entry name" value="[PSI+] INDUCTION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS18845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="561" mass="60445" checksum="6724E81B396AAE13" modified="2011-10-19" version="1">MAPVDVAMRRSLRAGFLDLLTRSIRPVVQRRNLGDQINDVKTAFSSWDNCMQVAYCKWPVIGLIIAAGLIIFGVTWCIIRCACCGLSCCCSCFKCLKCCGDCCGCCDPPRGNRRKYLDEPYIPPNHGGYKPQPPMFAGFGGSGKAADVPQYAEFDVSKPKDPDALPQMPTWEKAESKKVFLEEEEEGVEMNNLKKPEDNGQTAAPPTGAVPSRAVTPVSPRSPTHPVPYGPPGANAPTSNDQYGTGPGGYGSYVSQGAPDYNQPSMPYPEDDQGYSMPGTSRHSPQSYNNSSYNNGACSNGYSISGYNQGSSGYDNYGSPQQQQQPYDNYDIYNAYDTQPTQGYSTGYSQPTIDLSSTSVYGANPQSPAPSQHGPYNNPYSSADARRSPAPQGPYGNGYGSRHQSPAPQDYPAPTYSQEARRSPVPRNVPAPLSPGGSRSQDPRMSPVPMSPRSPGPRSPAPYAREYGGQSGSFDSTNSSHRASPYGQRQYTPDPTQPLRAPPPQRSYTGDFDFSTSGHSRPTGNGAYADSLYGDSTYASQGQGSNAGTMYPGYKPYQSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBX4</accession>
    <name>G0SBX4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminotransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0055130</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695845.1">
        <property type="nucleotide sequence ID" value="XM_006695782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBX4"/>
    <dbReference type="STRING" id="759272.G0SBX4"/>
    <dbReference type="GeneID" id="18259551"/>
    <dbReference type="KEGG" id="cthr:CTHT_0055130"/>
    <dbReference type="eggNOG" id="KOG0257">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_4_1"/>
    <dbReference type="OMA" id="IMAARDY"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43510">
        <property type="entry name" value="AMINOTRANSFERASE FUNCTION, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43510:SF1">
        <property type="entry name" value="AMINOTRANSFERASE FUNCTION, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="3">
        <location>
            <begin position="58"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS18900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="399" mass="44022" checksum="7C59BC303921BF1A" modified="2011-10-19" version="1">MVKIQPFEVEQWMDRLETTPGVLNLAETCAASVSLDDLIRMCEDKNSQNPLWLSAKLTYGAIRGSKTLRRRVAALYDRASDAEPLSSENVLISQGAIAANFLLLYTLVGPGDHVICVYPTYQQLYAVPESLGAEVSLWKLKEENAYIPDVTELEGLVKRNTKMIVINNPNNPTGSTIPPSVLLQIVSFAQQRDIIIFSDEVYSPLYHSLPSAQPAPPSILSLGYARSVSTGSMSKAFSLAGIRIGWIASRDRTIIEAVAAARDYTTISVSQLDDQVASFALSESVVGPLLKRNLGLAHQNLGLLEAFILRYKDHCEWVKPTAGTTALVRFKHRDGTPVDDPSFVLDLLDKTKVLVMPACPCFGLGKDFVGYVRFGYVCETEILIEGLRRLGKYIEEHLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G0SC77</accession>
    <name>G0SC77_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0056230</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695948.1">
        <property type="nucleotide sequence ID" value="XM_006695885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SC77"/>
    <dbReference type="GeneID" id="18259661"/>
    <dbReference type="KEGG" id="cthr:CTHT_0056230"/>
    <dbReference type="eggNOG" id="ENOG502R4JR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041041_1_0_1"/>
    <dbReference type="OMA" id="CIIASAH"/>
    <dbReference type="OrthoDB" id="5224680at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF49">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="2">
        <location>
            <begin position="91"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS19003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="386" mass="42604" checksum="7D4AD73B609DC2F0" modified="2011-10-19" version="1">MSAVGAGPILAAAIAPIAGKSTNLAHAVNASADVTDLPPGFPAELKSELAWTGADFDNTTEHIFVLTDAHKAEIKAAVEAYKLLDQDGDLVGPSNFPLPTLGPQLKQISRDVHDGRGFAVIRGLNPAEYSVADLTLAYLGVQSYVAEQRGRQDKCGNMLVHIVADNSTKQAADHHRHSTKSITFHNEEAGDVISWLTRSTAAAGGKCIIASAYTIYNVLAATRPELIRTLARSDWPFAMPRFHCRPIIFYEGEKLIMNFGRAPLLGNEAHPRPKHLPSVTRRQLEALDAIEAIARATQLEIQTQAGDIHFINNLSVLHRRDGFVNGQLPTEKRHLVRMRLRSAEHGWPIPAELQDEWHEAFRADGIRLWHVEPMPAYYFPLRDQPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCI9</accession>
    <name>G0SCI9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BAH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0057400</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696060.1">
        <property type="nucleotide sequence ID" value="XM_006695997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCI9"/>
    <dbReference type="STRING" id="759272.G0SCI9"/>
    <dbReference type="GeneID" id="18259778"/>
    <dbReference type="KEGG" id="cthr:CTHT_0057400"/>
    <dbReference type="eggNOG" id="ENOG502S1KY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028410_0_0_1"/>
    <dbReference type="OMA" id="NVKQWIE"/>
    <dbReference type="OrthoDB" id="10259622at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04370">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46364">
        <property type="entry name" value="OS08G0421900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAH" evidence="2">
        <location>
            <begin position="111"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="558"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS19115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="645" mass="72673" checksum="B3B16BD9B7C5184A" modified="2011-10-19" version="1">MAMQARKRPRNESEDLRAECPFTVRIVDPNQKDAGKKKKRRRTEGSEEGEKVLLQMSPFAPTGKFKTHETMDLHYQIEPAKQWSEMTRYNSFVLNGVKYYSEGFVYVANEASLERGKAAANDPQAQTSPSDEGWVARILEIRASDEHHVYARVYWMYWPDELPAGTIDGKKVVQGRQPYHGYHELVASNHMDIINVVSVTRQAIVKQWFEENEDEIQNDLYWRQAFDVRTYELSSVELVCSCNTPANPDRLLVGCSSESCKKWLHQECILENALRQTWNRLGADRPHIPIKKEEEDDANESKRPLSPTETSAEVAMQQSIDVKSEGEPDAVHVKQGNGVEIKRGEEDVQAAPEDAVASDVPLKSEPDTSANPSSSSAPETKEEPSSGSTLVSRPSRAGSVNRGKRNARPRKSKGHDASSESARPWEGKFEATLKMPDIGAPLIEIHDLREGVKGGEKTWTEPEADKRQSRTLRRRWRKMGMRRFSILNEQELESPGAGDKRKETIEDQERGAKVEEEPKAENLDDIKFEFESRTESQPLSSEARDHDYDPKASGSGHRPPQAQAEPQRPLQLLHQSRLQSPTQPDSQSGSSNITWYDALGSQNVEGDMNDDHGEDGEEEEQQEEARLATSPASFPGKKEETDDGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCL5</accession>
    <name>G0SCL5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0057660</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2021" name="Mol. Cell" volume="81" first="1781" last="1788.e4">
            <title>Mediator structure and conformation change.</title>
            <authorList>
                <person name="Zhang H."/>
                <person name="Chen D.H."/>
                <person name="Mattoo R.U.H."/>
                <person name="Bushnell D.A."/>
                <person name="Wang Y."/>
                <person name="Yuan C."/>
                <person name="Wang L."/>
                <person name="Wang C."/>
                <person name="Davis R.E."/>
                <person name="Nie Y."/>
                <person name="Kornberg R.D."/>
            </authorList>
            <dbReference type="PubMed" id="33571424"/>
            <dbReference type="DOI" id="10.1016/j.molcel.2021.01.022"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.58 ANGSTROMS)</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 14 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696086.1">
        <property type="nucleotide sequence ID" value="XM_006696023.1"/>
    </dbReference>
    <dbReference type="PDB" id="6XP5">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.20 A"/>
        <property type="chains" value="N=1-1168"/>
    </dbReference>
    <dbReference type="PDB" id="7JMN">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.58 A"/>
        <property type="chains" value="N=1-1168"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCL5"/>
    <dbReference type="EMDB" id="EMD-22284"/>
    <dbReference type="EMDB" id="EMD-22397"/>
    <dbReference type="SMR" id="G0SCL5"/>
    <dbReference type="STRING" id="759272.G0SCL5"/>
    <dbReference type="GeneID" id="18259804"/>
    <dbReference type="KEGG" id="cthr:CTHT_0057660"/>
    <dbReference type="eggNOG" id="KOG1875">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003573_1_0_1"/>
    <dbReference type="OMA" id="ITQGYIP"/>
    <dbReference type="OrthoDB" id="205099at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055122">
        <property type="entry name" value="Med14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013947">
        <property type="entry name" value="Mediator_Med14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809">
        <property type="entry name" value="MEDIATOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08638">
        <property type="entry name" value="Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26204">
        <property type="entry name" value="Med14_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="14 15" id="KW-0002">3D-structure</keyword>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit MED14 N-terminal" evidence="11">
        <location>
            <begin position="80"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1029"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1042"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1090"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1122"/>
            <end position="1156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS19141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="6XP5"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="7JMN"/>
        </source>
    </evidence>
    <sequence length="1168" mass="133069" checksum="EE172A5E8790B867" modified="2011-10-19" version="1">MEARAHGALPNNYDRERFINGVGGDDKALKRKLEEPLSDITKELDTVIAQSDVAVADPKGQLCPDADVPDEMEHITDGILPLNLLLIRLAEFSHSKLEELVTMLASKPVPQHAVNGNGSHSTLVEDASPESQEKKRLLLNTIQDLHSRWVKALVITEWARNAEKVGKLIDIRTHLFKKLELYPQVLNDFINLKRDMAWAKVPSPDLKTALHILTHGEVTWMPDFNFLDPPPLTTEETLRWINDMNLALHARLQLEEHDKLPPPFKNYTIDSGRVTFRVRGEFEVDLSISEEDFSEQFWFINFRFDFSPAPAELTPAVRYWMTEKVNNILKTEGLGGCYKYLHEFTLTQKIAELHRQAIALNKGRWANSLRVEKLNRNLGIHYWANRLHSQNLKSWIIIGVHSGEDPQGLEEPKPSYLMVQWFREGVEQFIDIPFSQEKLSIEEILEFVTAKHVGYLLFSLFRKFDGKPRFTQGKKARLELNVWTQKPEDYYLSMQLLDDEDLKIQVNPWMGDFITTPSTGPWNRTLNSLGNPAEEGSKELENFRYIYIISVLKAQGKSHGWSVVRSPISQDELRSIVHSESASSRETFQAAWTRFVDWDPQWYAMRSMSLAGDQWWLVEVTSQRQSISGNRLVFFTKMAPCFSEERLTDGFFNGLRDHSRRLIAEITNLRELYPGITPSQLRKLIDPTRQPPVLPVKASKILGDFGGADAQSIAWLKDPVWLIYRGSACDTRVSDSPQQKRTQPVLDVFEAYLDVTDRRRFQTLNPRLDRDILYNPYTGRFMFRLRAKMGVPVVPLLGIRVRQLQRLLDFLEGLRRVGDQAVPERVTLREIVFSYGATRKRDSTNQPKVRPWRVRLDLTKEEGVGVVLEKGNPHLRVINRLEDLVNSQKFYSLATYLTLSLPLFRAFEQLENAWQTAQENGRGSCFILHLSLDKHTIRFVLPGHQRQISLLIQPHEKEGKLVWEVGRPRHDPELLNENCEFNRVLKERVWTISGSGFKGLVTGAAAEPDEGIERLLVLISDAVLHLSTSQPATAPPQPPQAQPSQQVQQVQQQQVVSQLQPQAQQPRSAMPHASVGQQQPHGAPAPMARFPPQQQQIFQQQRPPQPQPNMHGGQISQPNMHGGPKPQLQGQHGQPGQMVAAPQQQGQRPGTGTAAGMGRSNAPLVVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCM7</accession>
    <name>G0SCM7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0057780</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696098.1">
        <property type="nucleotide sequence ID" value="XM_006696035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCM7"/>
    <dbReference type="GeneID" id="18259816"/>
    <dbReference type="KEGG" id="cthr:CTHT_0057780"/>
    <dbReference type="eggNOG" id="ENOG502SZWN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052692_0_0_1"/>
    <dbReference type="OMA" id="WILANSA"/>
    <dbReference type="OrthoDB" id="3641178at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="525" mass="58738" checksum="01D5BCC7DD403B72" modified="2011-10-19" version="1">MAGLIPLMLASSTRNNYIGSSQSCHSRRSSSASSLGSPGLPPTSPTFSQYPRQRLSKRISLPPPPLTDAVPTIPVTVTEWKQTIAQVKRQYFSKRYRACSARCLEVLEGVKDMPDVEPVYLIYLHFYAATSMEICARALPSTSALRTTLLQQARTHFDRASSLISSAEESIIRKARSGSAMSSRASSSCHSPSSSVSSSRAWTPDTQVSSPTESICSCDEKNSSRKRSKKVSFSLPRQQQQQQQNIQEPEPESETSYPVTPEPMVRPDSPTLGFDDSYFQAGAARQKLPEIPLSPKKFHEVELPLQQPQQQSPHQQLQSYTSQFTITPIPEEDEPEEEHNHHHHHHQQQQQQQQQQQHHRNQQHYDHEEDEDDDYSPPPSPTVARSVDRACEHLASLRSQLVRHAASLDELLSYSVQRMSMMGSSPSPAPASPTIPEFRPPVNIAGSSTTSSGPVRLPSMHRRAQSSTAMATMMHQGHNPLSREGARSADLQARIEKLRRCGWQRKRFDASRYEELCEAVMAELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCR9</accession>
    <name>G0SCR9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA-dihydrouridine(47) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="5">1.3.1.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">tRNA-dihydrouridine synthase 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">CTHT_0058200</name>
    </gene>
    <organism evidence="29">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>5,6-dihydrouridine(47) in tRNA + NAD(+) = uridine(47) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53364"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="22">
            <dbReference type="Rhea" id="RHEA:53366"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>5,6-dihydrouridine(47) in tRNA + NADP(+) = uridine(47) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53360"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="25">
            <dbReference type="Rhea" id="RHEA:53362"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="23">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="24">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Dus family. Dus3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.89" evidence="5"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696140.1">
        <property type="nucleotide sequence ID" value="XM_006696077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCR9"/>
    <dbReference type="STRING" id="759272.G0SCR9"/>
    <dbReference type="GeneID" id="18259858"/>
    <dbReference type="KEGG" id="cthr:CTHT_0058200"/>
    <dbReference type="eggNOG" id="KOG2333">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013299_7_0_1"/>
    <dbReference type="OMA" id="WSYIAEC"/>
    <dbReference type="OrthoDB" id="259935at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102265">
        <property type="term" value="F:tRNA-dihydrouridine47 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000145">
        <property type="entry name" value="tRNA-dihydrouridine(47) synthase [NAD(P)(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25585">
        <property type="entry name" value="zf-CCCH_DUS3L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0288">FMN</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="18" id="KW-0520">NAD</keyword>
    <keyword evidence="16" id="KW-0521">NADP</keyword>
    <keyword evidence="19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <keyword evidence="14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="27">
        <location>
            <begin position="308"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="DUS-like FMN-binding" evidence="27">
        <location>
            <begin position="553"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="86"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00031322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00045934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00049513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="EGS19195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="715" mass="81106" checksum="6D0FADE9819196EB" modified="2011-10-19" version="1">MVKRPIEETNGSSHHENGPGEPAPKRVKLDTAPDAAQELSQVATKQPRPRIKGVAPIKEEYLIFPSGHGKGSETDEFEVVADDAAEGRDAHDEQQGTGNDGKRKRKGGQNKDRDFGIFGDSHRLCNSVAWSPEFSPRTCKQGDRCNALHDLRKYLKEGRRPDLKTFDGKCPVWEKYGKCPSGWRCLFVRSHMQEVTREDGRTELMLTERNSDQGVVEHQDEQTGEVRPGVVNIMPTSIKIDLSRKRVKMEKSDEYLEWLSKDTELYRKHYHKSKDDADELNDYRAQYVEPPLKPSEKRRLYFGRETPILAPLTTVGNLPFRRLCVELGAQLTYSEMALSMPLLQGQNADWTLMRAHESEITPPRIDPKAPIVQGYEHSRDLKFGAQITANVPWLAIKATEALSRFLPHLRLIDLNCGCPVDAVYKTGAGSALMDAPSKLERMIRGMNTVSGEVPITTKIRMGVRDDRHTAQKLVERLALGSEDMRDVTGAPGCAAVTLHGRTRQQRYTRAADWGYIAECAALIKQFNEKADSLADTVRETDERTLPNGGHMYFIGNGDVYSHEDYFRHLDEAKVDGVMIGRGALVKPWIFEEIEKGQYLDKSSSERLSYIEKFCRYGMEAWGSDELGLNYTRRFLLEFMSFFHRYVPVGLLEYLPPSLNDRPPAYRGRNELETLLASKNYKDWIKISEMFLGPAPPGFKFTPKHKSNSYEIEAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0SD62</accession>
    <name>G0SD62_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Succinate dehydrogenase [ubiquinone] cytochrome b small subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0059080</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CybS family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696227.1">
        <property type="nucleotide sequence ID" value="XM_006696164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SD62"/>
    <dbReference type="STRING" id="759272.G0SD62"/>
    <dbReference type="GeneID" id="18259946"/>
    <dbReference type="KEGG" id="cthr:CTHT_0059080"/>
    <dbReference type="eggNOG" id="KOG4097">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096618_0_1_1"/>
    <dbReference type="OMA" id="SEGSYHW"/>
    <dbReference type="OrthoDB" id="18577at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098796">
        <property type="term" value="C:membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03496">
        <property type="entry name" value="SQR_TypeC_CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1300.10:FF:000007">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] cytochrome b small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007992">
        <property type="entry name" value="CybS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] CYTOCHROME B SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05328">
        <property type="entry name" value="CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <note>ligand shared with SDHC</note>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>a ubiquinone</name>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <note>ligand shared with IP/SDHB</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS19282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="174" mass="18777" checksum="6948E8DA878EEE9A" modified="2011-10-19" version="1">MASIARSSLLRQVASASRVSMATRPALQQSVLARAATFHTTSKRELLPPLPQRIKGTVNDAVPVPEPSPAQGSYHWTFDRLVAAGLVPLTVAPFAAGSLNPTLDAILCAGILIHSHSGFQQIIIDYVPKYRTPTARKLFMWGLNAATVVVGLALYEFETTDVGLTEAIKRIWTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDA6</accession>
    <name>G0SDA6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MAP kinase kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0051090</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695452.1">
        <property type="nucleotide sequence ID" value="XM_006695389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDA6"/>
    <dbReference type="STRING" id="759272.G0SDA6"/>
    <dbReference type="GeneID" id="18259147"/>
    <dbReference type="KEGG" id="cthr:CTHT_0051090"/>
    <dbReference type="eggNOG" id="KOG0581">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_23_1"/>
    <dbReference type="OMA" id="MIAKCLM"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000165">
        <property type="term" value="P:MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06620">
        <property type="entry name" value="PKc_Byr1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000253">
        <property type="entry name" value="MAP kinase kinase Ste7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000261">
        <property type="entry name" value="MAP kinase kinase Ste7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049613">
        <property type="entry name" value="Byr1-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE STE7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="60"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="338"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="375"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="395"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS18507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="484" mass="55807" checksum="A8A4BF3CBD8EF703" modified="2011-10-19" version="1">MADQRPDPFAPRTMKRKNVKGLALKTAPKAPAGGLGMRREEPTQLEIGIEFNLDLKAEDLEVIKDLGAGNGGTVSKVRHIPTNTVMARKIIHVEAKKEMRKRIVRELQIMHGCHSEYIVTFYGAFLNENNDVVISLDRISKKFGPIRVDVLGKIAEATLGGLTYLYAKHHIMHRDIKPSNILVNSRGQIKLCDFGVSGELINSIADTFVGTSTYMAPERIQGEKYTVKSDVWSFGLTIMELAIGKFPFSASEEFAEEDSGPAGILDLLQQIVHEPAPRLPKSDAFPQILEDMIQKCLSKVPDERPTPQELYDRDPFIQAAKRTPVNLQEWACGLIERDNRKSHLQPQPSPSTQELLRSSDSPTYHGDASGSTPTYRDHRDHRDYRDHREHREHREHRDPRDYREQHRDYRDYRDHRGYEDHYGGDHRDYRDYHDARGDYHDSRGYHDERDPREYVDPRDHRYAVDQAGLPAQMDRLYIRDWDHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDB9</accession>
    <name>G0SDB9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cysteine desulfurase</fullName>
            <ecNumber evidence="3">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0051230</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters. Plays a role in both tRNA-processing and mitochondrial metabolism. Involved in the 2-thio-modification of both 5-carboxymethylaminomethyl-2-thiouridine in mitochondrial tRNAs and 5-methoxycarbonylmethyl-2-thiouridine (mcm5s2U) in cytoplasmic tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(sulfur carrier)-H + L-cysteine = (sulfur carrier)-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="3"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695465.1">
        <property type="nucleotide sequence ID" value="XM_006695402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDB9"/>
    <dbReference type="STRING" id="759272.G0SDB9"/>
    <dbReference type="GeneID" id="18259161"/>
    <dbReference type="KEGG" id="cthr:CTHT_0051230"/>
    <dbReference type="eggNOG" id="KOG1549">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_0_2_1"/>
    <dbReference type="OMA" id="KGLYWAR"/>
    <dbReference type="OrthoDB" id="10250117at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990221">
        <property type="term" value="C:L-cysteine desulfurase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000003">
        <property type="entry name" value="Cysteine desulfurase IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000002">
        <property type="entry name" value="Cysteine desulfurase IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00331">
        <property type="entry name" value="Cys_desulf_IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02006">
        <property type="entry name" value="IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010611">
        <property type="entry name" value="PRK14012.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601">
        <property type="entry name" value="CYSTEINE DESULFURYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="13">
        <location>
            <begin position="124"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="44"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS18520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="523" mass="57076" checksum="187089E435C6BB33" modified="2011-10-19" version="1">MANLAPSVLRQASRLATRSSSSTSSLFAAAPRRAATLLSRRAAIAPATHAHPSRRASRSYVTDTKADNAQAQTEAAVRLDSQELEKAEKSVPSFEAQNGSTTHVSPMADILKGATRMGEGQRPIYLDMQATTPVDPRVLDAMLPYYVGIFGNPHSRTHAYGWETERAVEKAREHIAALIGADPKEIIFTSGATESNNMSIKGVARFFGRTGKKRHIITSQTEHKCVLDSCRHLQDEGYEVTYLPVNNKGLINLDELRDAIRPDTALVSIMAVNNEIGVIQPIAEIGKICREKKVFFHTDGAQAVGKIPIDVNAMNIDLMSISSHKIYGPKGIGACYVRRRPRVRIEPIISGGGQERGLRSGTLAPALVVGFGEACRIAKEELEYDLKHVKRLSERLLKGVLSIECTHQNGDPENGYPGCVNVSFAYVEGESLLMALNDVALSSGSACTSASLEPSYVLRALGNSDENAHSSIRFGIGRFTTEAEIDYVVKAVQDRVGFLRELSPLWELVQEGVDLNTIEWTQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDD9</accession>
    <name>G0SDD9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative structural constituent of cell wall protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0051440</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_006695422.1"/>
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    <dbReference type="STRING" id="759272.G0SDD9"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Sed1/Spi1"/>
    </dbReference>
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        <property type="entry name" value="CELL WALL PROTEIN SED1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CELL WALL PROTEIN SED1"/>
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    <keyword evidence="2" id="KW-0732">Signal</keyword>
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            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
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            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS18540.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="145" mass="14547" checksum="B18271E0E0F0C10A" modified="2011-10-19" version="1">MKFFAAALALAAGASAYSNVTYVTEVVTAYTTYCPEPTTVVYNDHTYTVTEATTLTITDCPCTIKKPVTTISSVVCNTPNCGGGYHNTTGPVPTPDVPAGTAHPPVVTSTPSPQPEVPVTAGAGRAAALSGAGLAALLGVAAFAL</sequence>
</entry>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
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                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
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            </authorList>
            <dbReference type="PubMed" id="21784248"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
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        <subcellularLocation>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
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            <end position="1037"/>
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    </feature>
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            <end position="1331"/>
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    </feature>
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    </feature>
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        </location>
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        <location>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1789" mass="200716" checksum="EAABA6DD0CD7E53A" modified="2011-10-19" version="1">MPGQEVHTGNGEDDHDHDHPDILDGLDGITNASLGLSEALAQQQQYQQTKGQTLQRRMPAPPAQSFIPSLSELLRGRRSWSKSGSSSPLVVSQGSQSLIKSESRSRSRSRSRSRRRRRSTTYARERMDSDMDQEPFVGSGYQPGDKGSEFQPNAGSEYQPDDASLYKSEDDLQPEYYPSMDLDSDYQPSEWQHDPDEEMDDLDDDLPEVPGTHKRKRNDDDGDDDNVYADDYYYYDEQESDDDIVSEPRGGGIRPRLGPMDDFLDAVPSRRSTRTSTRPSSSQLVSIEGGNQPGGNDLGSMRTRRLRPRVSYSYSMNGVYDDKDELQDSDGDDTNISLVQSDIVQPRKQRRLTALRKPPARIWTQQKAQAAKQTEDWGDSDIEFEDRRRRSSRSTRATKIISDTYLDDEDITYVDDDRPPAAAAAAAAAAAPRIPNMRELFPPPPPDFKFFHSPTCDVCGHAADDRIKGAMVPCQGCSNSYHKACLGNRSMREHAVTKVGPDMFVLQCRWCIGVHKKRDERAPKYDMCQKCGGRNPSCVRFAPRRTPKQEEVMRAENGGVDPVTKVEGTLVNNSERVLFRCGRCKCAWCWECLPLPGKTTSGAGGDLTKARRARLEEYGISWMCRLCQDTEELKIDKIVAWRPARRELYSEGKTLLDFTEDQLEYLLKWEHKSYNHCVWMPGAWVYGIAKHAMRQAFIRRTLGQGSGDVEGERHTDSLLRWHEKDAIHDVWITPDIILDVRYATRSKEDENRYRAMSRSDRFEYDLDRVFHVVKIYVKFEGLGYDDVVWDTPPSPDSGPIWDAYLDAYREYLNGKHFRPEPWPAMRARIERFRQMDFGDIEVKEQPPGLREGCKLMAYQLEGLNWMLYNFRYERSVILADEMGLGKTVQVVALLASFILTAPKVWPFLIVVPNATCANWRREIKKWAPDLRVVAYYGGKVSQTLALDFELFPGGARDMRAHVVIMSYDSVKDCDPRLKSVKWAGLVVDEAQALKSDESALYRVLSSLKIPFKLLLTGTPLQNNKRELFNLLQFIDPAMRADQLDERFSQITSENLPELHDLIRPYFLRRTKAMVLTFLPPMAQIIVPVSMSVLQEKLCKSIMERNPQLIRSVFVQQGGKLKPSERGSLSNILMQLRKCLCHPFIYSQAIEDRNVPPEVMRRNLIEASPKLMLLEIMLPKLKERGHRVLMFSQFLDQLTILEDFLNGLGLKHERLDGNQSSLEKQKKIDAFNAPNSDIFAMLLSTRAGGVGINLATADTVIILDPDWNPHQDIQALSRAHRIGQRRKVLCFQLMTVDSVEEKILQIGRKKLALDHLLIEILDNEEDAPNDVESVLKHGAAALFGEGKKKEAIMYDSAAVERLLDRSMMEETKTGEDKSAESAFAFARVWANDEGGLKDDLQVKETSVSVGVWEQILKQREEEARREEEAKLERLGRGGRRRGAAYASYTGPRFEFDDGADAAAAESDQADGDGDFVGSDKSDAESSDEEEEVVVVVEEEGEEERDSEAANGKSTLEKEMQESQSETRTAGSLAGQDGAVPASLTKIARKKAAGSPDGASTTTTTMTTTTTTTTAKSRNIKATAAGSLASLSTAVVSTPKKARVRKQQAQTDTTTPSSAPRTTSSRKRPKQTPKSTTQTSPTSAQKTSKKTKREPSAAKKAVQAAVAAAASAAAARRRRARPPAQMQQLQSSALSTERGTQSKGRKVREMENQGQEVRPQEQEGQAQAQAQGLRLPPNLVPDKNVTATLCSTGMPALGLGMDPLVVRLLQSQVQQQGLLPAQPPIQQRERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDL3</accession>
    <name>G0SDL3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Polyamine transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0052190</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695559.1">
        <property type="nucleotide sequence ID" value="XM_006695496.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0SDL3"/>
    <dbReference type="GeneID" id="18259257"/>
    <dbReference type="KEGG" id="cthr:CTHT_0052190"/>
    <dbReference type="eggNOG" id="ENOG502RYRH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_262720_0_0_1"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="533"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="571"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="603"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="642"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="702"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="732"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="801"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="832"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="885"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="973"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1006"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="71"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="158"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="275"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1052"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="275"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1059"/>
            <end position="1074"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS18614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1285" mass="141190" checksum="D6BDF0A628215C9A" modified="2011-10-19" version="1">MKANDNGTPKGPPRSQSGNDQSSIRFLNGPYCCSDVQFDAKEAIVVGWGGAKTYFKALQQLSASHHARLDNTSEFSTDPDNSQVPDTDINDPSGAPSSNSITGTDPQATPDQILNHGPGEASRAWGRRIHQLADGRVYEELPLRHAASSGEAYISGFVETPERGPRHSPREIEEGQSNLSSRKSTLVSGGSTPIDFKFKRAVSDMEHLLEEVMELAKQVTEQDDNYGCISPLELKDARIPSPRIVDAPAEAAHGFMSGAIIDNPRVAELNLTPQAQASKQASTNARQQKQLKRYQSAPGMRNTSGREHEMMAPVRLRRSKRSRLTIPERWKEDLPDEQPSQVTQRDRPPVTLISVRKDSEPRSREVKAGDDAPREPGCLFHMKLLRKSQSWRHPRVSPSPRRTRSYRFEVNPRFDNEKDCVQDVPTMPRDKHLKPVKERRRDTSTASCFDGVMDEDDITPIDTHIQQPSMDNTPNIRQPYMSLPPIQRPTEHDLKPSAVQQTNLSITPEIPSSSGQITDVTPARDWSPLRKRFTATVACLSTTAVGIVIGMYAGLVPAIQYRIADAGHHVILGNVLLYLGLAISSFVTWPLPLSKSRRLGRKPYVVGGLAAAIPLLIPQAIASSYALGPGYRYYLAEYGLHWWRWVVLAVSRGLMGIALGVPSANWMGVLMDLFGASLMSGNPHQEWVDETDVRRRGGGMGVWLGLGTWCFTGSLGVGFAVGASIIDGGRSPAWAFGVAGGILLVLLGLNIACPEVRPRLDTAAKQQKNGKDKNDAVKTPWWLVALQGMSLSAEMLRQPGFLVIAVYTGWIYAQIVLIIVLLGALASRYYTLRSTLVGLCVAFISIGGIIAIPFQKANLFSRWRHHQGPTSADTLDDRFVWTSHFVRRAVFCIFLPLFGIAYTVASAGPPIPVEIPTLLAAGIGGLSALAISECNGLIMETFDTSDLPVTSSSASPRKVDQSQWVDPSSYPRVAAGFAVCHAIGFVLAAIATAVGGSAQRHLGQQAATGVVAGILLILTGLLLAVLIRFRNVHIIPNCKTLEMDRWTEMRRESLRRQSQRSSARTSRTSSMAASNHISPTNNKALSVLATDDLAEMDMWRPILLGNPSCKMRRVNVLELGALSRWTEIRKTNRLIDQRAAAHLNRAALGSAAVAVEEATGIAGLVRKVSHRRRHHHHRGTDEEEFHSYNHHFGRDLPFHHGRRHVRGAENEDAQGIELAILGRIDGQENPPAHAGLQGNRENAAEQRIEKARDEFVGSSFDDYGTLRAREVKMRKVTGGEVKMTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEQ2</accession>
    <name>G0SEQ2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0064560</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696760.1">
        <property type="nucleotide sequence ID" value="XM_006696697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEQ2"/>
    <dbReference type="STRING" id="759272.G0SEQ2"/>
    <dbReference type="GeneID" id="18260494"/>
    <dbReference type="KEGG" id="cthr:CTHT_0064560"/>
    <dbReference type="eggNOG" id="KOG4245">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039329_5_2_1"/>
    <dbReference type="OMA" id="GHMGERI"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF31">
        <property type="entry name" value="AMIDOHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G05840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="50"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS18429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="349" mass="38890" checksum="546E60DAE1CBDD79" modified="2011-10-19" version="1">MAVGNIKAQKGTIAIEEAVINPTGLSWLADSAALFGQEASTESHTTLTERLLDIHHDRLKQMDTHGVEYMLLSLTSPGPQGEPNPAKARALATEANDWLAAQVALNPQRFGALASVSMHNVEDAVAEAVRAVKELGMFGVVLNDYQVVNEGGDVEGKKYYDTPEFRPFWKAVEELGVPVYMHPRFPPAKDLQPGTRYGDRKQILGGAVQFHLDLSLHIYALCSSGVFDEFPGLQVVVGNLGEGIPFSLWRADHWYNKPGKLKTRPSKHDFTYYFTKNIWITTAGNFNTPGLKFCVDQVGPERCLFAIDYPFDSIAEAQYWWLTVDLPEDQKQLIARENAIKLFKLPLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEW8</accession>
    <name>G0SEW8_CHATD</name>
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        <recommendedName>
            <fullName evidence="2">Trafficking protein particle complex II-specific subunit 65 IgD3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">CTHT_0059970</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS17984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="759272.G0SEW8"/>
    <dbReference type="GeneID" id="18260035"/>
    <dbReference type="KEGG" id="cthr:CTHT_0059970"/>
    <dbReference type="eggNOG" id="ENOG502SGQ1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015118_0_0_1"/>
    <dbReference type="OMA" id="IFSWTVY"/>
    <dbReference type="OrthoDB" id="5345392at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055420">
        <property type="entry name" value="IgD3_Trs65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024662">
        <property type="entry name" value="Trs65"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28159">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX II-SPECIFIC SUBUNIT 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28159:SF1">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX II-SPECIFIC SUBUNIT 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12735">
        <property type="entry name" value="IgD3_Trs65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex II-specific subunit 65 IgD3" evidence="2">
        <location>
            <begin position="427"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="476"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="549"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="649" mass="70879" checksum="EA06E469E4CB35D6" modified="2011-10-19" version="1">MSQETIPEQLTEAQIVSDVFLDRAYLTYIVPLSTSFQPESLSEGSGDIASRLTNLEKREHLFFDEAVDVYMILRTASVHEQAFRHALPRLVLNLEAHILNGVGPDRENPPASEIIWNGRVEDVEKAYFLTDNDPNVDENDRYVYAFWKLSVFLDRPRMRLQHPSVVFSGSAALRSSSKPTEQQQERLAGYMQSCMPSAMNLLDTFAHDPMLGGIRPRLSAQRVSRVAPLTKPKDVLRRIDGLQHLRLRIYPVLHTRVRFSRPNTAPPSTAVIAMLEIDFTPYFDCEIVLDGISLTVAGGTVEDLNNKDMTLPLSCVAHDHLTFLYKLSPQPLDFLTSASRSQPNLTRDLAIKISARALVRPDTDGEPNPCTPGLTMSWTTTVDFTPPVNPGFGKPSTQPMQRAHKPSQLSISGGVVSQPLVSPSVIRPDALPSLEASTSRAQETQIPELGITLTFTGPSKPVRVGEEFVWSVSVVNRSRSDSQSTSTPGTSTGSPFAPTTRPSSSGGTSGQPSSVPGTARKLLLIPLPRRRRNETRVSRPIAPSPSPNAPNSTSSQSQRPDIPPIAPAIQDEALVHAMQRSSVADVQELACLSADIRVGPLAGNACAMAEMRFIPLREGVLGLEAVRVVDVATGEHVDVREVPGVVAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEX0</accession>
    <name>G0SEX0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase epsilon subunit D</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">DNA polymerase II subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0059990</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS17986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696317.1">
        <property type="nucleotide sequence ID" value="XM_006696254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEX0"/>
    <dbReference type="STRING" id="759272.G0SEX0"/>
    <dbReference type="GeneID" id="18260037"/>
    <dbReference type="KEGG" id="cthr:CTHT_0059990"/>
    <dbReference type="eggNOG" id="KOG0870">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043417_0_0_1"/>
    <dbReference type="OMA" id="NTYRRKV"/>
    <dbReference type="OrthoDB" id="1707486at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22928">
        <property type="entry name" value="HFD_POLE3_DPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051377">
        <property type="entry name" value="DNA_Pol-Epsilon_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46172">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46172:SF1">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="7">
        <location>
            <begin position="101"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="29"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="230"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="32"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="277"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS17986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="357" mass="38094" checksum="B2C6B533ED1D6C40" modified="2011-10-19" version="1">MPARKSDARRSTGGDASVARFVLADDVAGADTSTASEPATSSSTEPKQLSSSTSAEPAASSSAGQPASGAPLSEAGKKDKEKDKEKEKEKEKEVITIEDLTLPKSIITRLAKGVLPPNTQIQANAILALTKGTTVFINHLASAANEHTVAAGKKTIMPADVFKALDEIEYGFMREKLEAEFAKFSQVQSSKRSAYRKKVAAAKKAASGTAADVSMISTATDDAGVSQYNGAAETSGTKSVSKGSKSSKSASGDGTRAVKKARLDPSASVDSSKMDVDDGDEGGEDEDMSDVGTVEDDDQPEEEEEEEEEEEEEEEEDVGEEEEEEEEEEEEEEKDELEEREEREDRDEALDDGDESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEZ0</accession>
    <name>G0SEZ0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0060190</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696337.1">
        <property type="nucleotide sequence ID" value="XM_006696274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEZ0"/>
    <dbReference type="STRING" id="759272.G0SEZ0"/>
    <dbReference type="GeneID" id="18260057"/>
    <dbReference type="KEGG" id="cthr:CTHT_0060190"/>
    <dbReference type="eggNOG" id="KOG4210">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026791_2_0_1"/>
    <dbReference type="OMA" id="EIRIVMN"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF119">
        <property type="entry name" value="NUCLEAR RNA-BINDING PROTEIN SART-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="305"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="410"/>
            <end position="488"/>
        </location>
    </feature>
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                <person name="Flemming D."/>
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                <person name="Kunze R."/>
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        <citation type="journal article" date="2017" name="Nat. Struct. Mol. Biol." volume="24" first="954" last="964">
            <title>3.2-A-resolution structure of the 90S preribosome before A1 pre-rRNA cleavage.</title>
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                <person name="Cheng J."/>
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                <person name="Beckmann R."/>
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        <citation type="journal article" date="2019" name="Mol. Cell" volume="75" first="1256" last="1269.e7">
            <title>Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration.</title>
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                <person name="Cheng J."/>
                <person name="Bassler J."/>
                <person name="Fischer P."/>
                <person name="Lau B."/>
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                <person name="Kunze R."/>
                <person name="Griesel S."/>
                <person name="Kallas M."/>
                <person name="Berninghausen O."/>
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        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="476" last="476">
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                <person name="Gese G.V."/>
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            <title>Methionine aminopeptidase 2 and its autoproteolysis product have different binding sites on the ribosome.</title>
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        <text evidence="1 4">Belongs to the universal ribosomal protein uS17 family.</text>
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    <sequence length="161" mass="18656" checksum="759E6E563D36EDD1" modified="2011-10-19" version="1">MATELTVQSERAFLKQPHIFLNSKVKVKSTRPGKGGRRWYKDVGLGFKTPKTAIEGHYIDKKCPFTGMVSIRGRILTGRVVSTKMHRTIIIRREYLHYIPKYNRYEKRHKNLAAHVSPAFRVEEGDMVVVGQCRPLSKTVRFNVLRVLPRTGKSVKKFQKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0SF02</accession>
    <name>G0SF02_CHATD</name>
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    <organism evidence="6">
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
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                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
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                <person name="Hurt E."/>
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            <dbReference type="PubMed" id="21784248"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
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    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG14 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696349.1">
        <property type="nucleotide sequence ID" value="XM_006696286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SF02"/>
    <dbReference type="GeneID" id="18260070"/>
    <dbReference type="KEGG" id="cthr:CTHT_0060320"/>
    <dbReference type="eggNOG" id="ENOG502SEGC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021590_1_0_1"/>
    <dbReference type="OMA" id="HYLSIRL"/>
    <dbReference type="OrthoDB" id="16772at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018791">
        <property type="entry name" value="UV_resistance/autophagy_Atg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157:SF13">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10186">
        <property type="entry name" value="ATG14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="358"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="475"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="475"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="494"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS18018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="520" mass="57619" checksum="974BD06AB13C1A02" modified="2011-10-19" version="1">MRCDICHRPHHTKRLPFLCAVDARNRLYEGRLEYARALIQAEEAESRVNDALEKAAAARDPKSKLKKDEKDVAAARIAWLTAEEQAALERTSHIIAQADKLRSEIEAARKEIAVKKDAIARRRSDLMAVTAGTVSRRARQLDEVERSTQRLRYKWNRIADATAITRAFLCEEAARLYGLRQIEEGSAKRYEIGGVELFDLHTMNGLSPELISTSLAHVAHILVLACDYLAIRLPAEITLPHKDYPRPTIFSLSSSYKHDKVIFPGSALAIQQSAAAAAEDKRLPRPRPLWTDRPLPTLAKDYPDVYSYFLEGVALLAYDIAWVCCSQGVSLGDGDPFEEVCAIGKNLWRLLIAGKHHNAHQPHKNRRRSPEPAPYSPLSGNSPRTEDIAGEMANPKSSTSTLGRWSHGTCHSYLGTAEGMEFIRSFKLLSPYKIYDKLKRRLSADAPLMDWERIEGDELDDGFEDGMLGRIEAGGNSAGMNAGNGPPDIRLDRGNGGGGSSHGGIGIPKGTSGWTKLRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFC2</accession>
    <name>G0SFC2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">galacturonan 1,4-alpha-galacturonidase</fullName>
            <ecNumber evidence="14">3.2.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CTHT_0061530</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl](n) + H2O = alpha-D-galacturonate + [(1-&gt;4)-alpha-D-galacturonosyl](n-1)</text>
            <dbReference type="Rhea" id="RHEA:14117"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14572"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58658"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.2.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.67" evidence="14"/>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696469.1">
        <property type="nucleotide sequence ID" value="XM_006696406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFC2"/>
    <dbReference type="STRING" id="759272.G0SFC2"/>
    <dbReference type="GeneID" id="18260191"/>
    <dbReference type="KEGG" id="cthr:CTHT_0061530"/>
    <dbReference type="eggNOG" id="ENOG502QRJW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_535474_0_0_1"/>
    <dbReference type="OMA" id="WHTFVAY"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047911">
        <property type="term" value="F:galacturan 1,4-alpha-galacturonidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF12">
        <property type="entry name" value="EXO-POLYGALACTURONASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409521" description="galacturonan 1,4-alpha-galacturonidase" evidence="17">
        <location>
            <begin position="20"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGS18138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="490" mass="54544" checksum="8ACF98BD4C2BF7A7" modified="2011-10-19" version="1">MLLSNLILVLSIIFLPASGSLFKEGSTCIVTPISASPQALVRRSIDTVPSTGRDVDPDQSTGLWDVIDPYKSPAPGTPGALTHFPHPEPGRAHFHARRGLSPFEREVEPLTTRQTPAPVDDTPQILEAFKQCGQDGTIIFREGTYHIRQVMDTTDLRNCSIEIHGTWVWSADNIPYWRQRSFSVTYANRQTAWRLGGRDVSLRGFGKALFDGNGQVWIDLARGQANMDGRPISLTIWKGTNVLIDGIRWQMAQFWHTFVAHSQNVTMTNLEMHTYSKSSQSSVNTDGTNTWNSRDIYIANWTVTSGDDCIAVKGNSTNVHVRNVTCYESGAMVIGSIGSNSWQPDYVENVVFEDIKLNHSSNAAWIKTYPGTGYVRNVTFRNIEFSDVNQPIYVTACIYSYRGCDNSRIPITDIRWENITGTSRYNVAAAMRCSSQAPCDRFSFSNINIRPKNGETAKVLCTNIRNQATMGLTCTGSMPESHPQQLNGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFP7</accession>
    <name>G0SFP7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0071630</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697430.1">
        <property type="nucleotide sequence ID" value="XM_006697367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFP7"/>
    <dbReference type="GeneID" id="18261201"/>
    <dbReference type="KEGG" id="cthr:CTHT_0071630"/>
    <dbReference type="HOGENOM" id="CLU_1970284_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="127" mass="13826" checksum="97AA0B005B445D5D" modified="2011-10-19" version="1">MPQAGACVLAALKRARDDKVKELNANISIVEKLVDAMVDSQLKSPLEKSDDVPPTSAPPKQPHWADVAATPLQSPQRKKQTTHSHPSPSGSHARPMDRTASRHVFLRMNKTESANAFWSHTSSIAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFQ0</accession>
    <name>G0SFQ0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Putative DNA repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CTHT_0071680</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697433.1">
        <property type="nucleotide sequence ID" value="XM_006697370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFQ0"/>
    <dbReference type="STRING" id="759272.G0SFQ0"/>
    <dbReference type="GeneID" id="18261206"/>
    <dbReference type="KEGG" id="cthr:CTHT_0071680"/>
    <dbReference type="eggNOG" id="KOG1001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_2_5_1"/>
    <dbReference type="OMA" id="KVEPWSN"/>
    <dbReference type="OrthoDB" id="2801544at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16572">
        <property type="entry name" value="RING-HC_SpRad8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014905">
        <property type="entry name" value="HIRAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF22">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08797">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24975">
        <property type="entry name" value="UBA_Rad5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00910">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="481"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="875"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="965"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="352"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="358"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGS17815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1131" mass="127525" checksum="6BA9724AABB76897" modified="2011-10-19" version="1">MGSTDPNEPPVKRQRFLADSDDTADPKIAKSSALVSNKDSCIYINEVTTPHIKPGLSGNASMHDDFDQATFDAFVGEHVSPDIMAVIRRKCGSDIERAVNMYLDGTWKTPGKSVRTTGLHLSSRMTETPVRNPFNPMVLQPNANRIMPESRYIGAFGVEGWATRSGTGLLKHGDPIRIERQKIQPVKSSSPRGGQRVKLGTPAPGSLMGAVAAKRVDVIVRFTDSTGREIGRLAKDKAEWVSTLIDQKICRFEGTCVYAPESLRTNDTVVLQLRCYLLRSAFDPRTFKVTSNSPFGHFESGESEEERDLRLRQVALVKLFQEINLLPIRGNAAAASAQRQSLLHAAELAEDSEKTKAKSQAQDTLGSSSLSDENEDGQELEQDQLDALYKKAQSFDFTTPEAEPASSFAMTLRPYQKQALHWMLSKEKNVHIEERETSMHPLWEEYAWPKKDHDDKDLPEVPDQPTFYVNLYSGDLSLEFPRQEQRCLGGILADEMGLGKTIQMLSLIHTHRSEVATRARASGHHGEWITPGQRFLVPAARGTVIDAPCTTLVVAPMTLLSQWQSEAENASKEGTLKSLIYYGSEKNMDLVALCCEANAASAPDLIITSYGVVLSEFNQIAYNHRDKTRNRGIFALKFFRVILDEAHTIKNRLSKTARACYEIAAKHRWVLTGTPIVNRLEDLFSLVRFLRVEPWDNFSFWRTFITVPFESKDYMRALDVVQTVLEPLVMRRTKDMKMLDGTPLIALPPKHIEVVEVELSKEEREVYDYIFKKAKRTFQANVEAGTVMKSFTSIFAQVLRLRQSCCHPLLIRNQENVADDVEPGTAADRAAQLGDDMDLQSLIERFTATTDDASQPNAFGAHILQQIRDEAVNECPICAEEPMIDQTVTGCWHSACKQCLLEYIKHQTAQNQQPRCFQCREVINSRDLFEVVRHDNDTTNPESGQGPRITLQRLGASSSSAKVTALVNHLRNLRREHPTMKSVVFSQFTSFLTLIEPALRRASIKFLRLDGTMHQKARSAVLAEFKESQNFTVMLLSLKAGGVGLNLTSAKRVYMMDPWWSFSVEAQAIDRIHRMGQEDEVRIYRFIVKDSVEQRMLRIQDRKKFIATSLGMMTDEEKKLQRIEDIKELLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0SG20</accession>
    <name>G0SG20_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA repair protein Rad26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0064730</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696777.1">
        <property type="nucleotide sequence ID" value="XM_006696714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SG20"/>
    <dbReference type="STRING" id="759272.G0SG20"/>
    <dbReference type="GeneID" id="18260511"/>
    <dbReference type="KEGG" id="cthr:CTHT_0064730"/>
    <dbReference type="eggNOG" id="ENOG502RZ1G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013058_1_0_1"/>
    <dbReference type="OMA" id="EMAHEML"/>
    <dbReference type="OrthoDB" id="5245063at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048379">
        <property type="entry name" value="Rad26-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022093">
        <property type="entry name" value="Rad26-like_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048380">
        <property type="entry name" value="Rad26-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21046">
        <property type="entry name" value="Rad26-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12331">
        <property type="entry name" value="Rad26-like_helical_rpts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21048">
        <property type="entry name" value="Rad26-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad26-like N-terminal" evidence="4">
        <location>
            <begin position="397"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Rad26-like helical repeats" evidence="2">
        <location>
            <begin position="503"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="Rad26-like C-terminal" evidence="3">
        <location>
            <begin position="782"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="727"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="727"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS17159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="847" mass="94164" checksum="D5C189DE0F89075A" modified="2011-10-19" version="1">MDEYEDDTFNELDNSILQELENNAIQATQAKLAQTQGLAQSQFQFCPPQAQFRPIQPIQPPRRPQNQLQQQHNVSDYGLDDDDFDDTIVIDESARLPPRTAIEKTISQNQPRLAAVAGGTQRWNQHLPQPRPTYPPRPQFRRFPQQSPQTFSSPRYPPGSSRPQPHHPLQPSQFSRPAPFVPRPSPPVRPPQVAYPFQPSQPPHAGNQNDLIAELTAKLNALEQELITARGEASILRSKYDKAQAAHDAELAALKKKTAEQLAKQERLIEEARAAEKMATTELQFARQDLREELTRTKARRKDKDGGAGPSTPRKNRAWGVPDGFDDVEILGTSPNKGQARRREAAGDRTPTKKRKRPVVDSPTFVLETEGGDVQVVKAPKPAPVMLSSRPGLSFDFLRVIIDHGTVREQPPTFDLLSRFSFPSDPTQSFSSIIFQKLPKIGDSHDPLRLLADFVELIIDLWQRCLSERYHTPIYYLASLALYTLLLNTESVAPHIISSLIPVCATTCRLVALPRLNSVDGNLAEHPDPAVRQLLSEIDVGQCLSLLHLAALGCLSPPVDDGDNTQQPKTSTQTQFWRTMELDFVLLMLSPKHPETEWLQMLNLLWTSVTPDSLGPIPSFATDQSAGSERPGDIHTTTGIAAMVIDCVSSFLCEPPLWATPGTIKDAGVRIAAVQTLTMFATSPFGAMQLAMSDVAIPRLVTVLSWAIDRLYDMDVEFPLRPEKRPLFDKDEMQHDCPKPSEADDNEESHEPDPMTLFCRLIAETTKLLHYLATDSRTANVANLAGKLAASYGGSQRHLISLARLNFAEEDLIFEAGIDAETIELAHDLIELAVTPDEGREVVEVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0SG40</accession>
    <name>G0SG40_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Beta-glucosidase cel3A</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Beta-D-glucoside glucohydrolase cel3A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Cellobiase cel3A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Gentiobiase cel3A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CTHT_0064940</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696797.1">
        <property type="nucleotide sequence ID" value="XM_006696734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SG40"/>
    <dbReference type="STRING" id="759272.G0SG40"/>
    <dbReference type="GeneID" id="18260532"/>
    <dbReference type="KEGG" id="cthr:CTHT_0064940"/>
    <dbReference type="eggNOG" id="ENOG502QR4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_2_3_1"/>
    <dbReference type="OMA" id="MTDWNAQ"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000757">
        <property type="entry name" value="Beta-glucosidase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000003">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF28">
        <property type="entry name" value="BETA-GLUCOSIDASE L-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409208" description="Beta-glucosidase cel3A" evidence="18">
        <location>
            <begin position="21"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="19">
        <location>
            <begin position="653"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00070030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00078013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00083231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGS17179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="734" mass="78886" checksum="9E9EBCB74D5BF9A6" modified="2011-10-19" version="1">MVLQTFLLLASALLARGALSQPDNVRRAAPTGPAAWDAAYSQAAAAVSRLSQQDKINIVTGVGWGKGPCVGNTNPVYSINYPQLCLQDGPLGIRSATSVTAFTPGIQAASTWDVELIRQRGVYLGQEARGTGVHVLLGPVAGALGKIPHGGRNWEAFGSDPYLTGIAMSETIEGIQSEGVQACAKHYIANEQEFNRETMSSNVDDRTMHELYLWPFADAVHSNVASVMCSYNKLNGTWLCENDRAQNQLLKKELGFRGYIVSDWNAQHTTVGSANSGMDMTMPGSDFNGWNVLWGPQLNNAVNSGQVSQSRLNDMVQRILAAWYLLGQNSGYPPINLRANVQANHKENVRAVARDGIVLLKNDGILPLQRPNKIALVGSAAVVNPRGMNACVDRGCNEGALGMGWGSGTVEYPYFVAPYDALHERAQRDGTQISLHASDNTNGVNNVVQGADAAFVFITADSGEGYITVEGHAGDRNHLDPWHNGNQLVQAVAQANKNVIVVVHSVGPIILETILNTPGVRAIVWAGLPSQESGNALVDVLYGLVSPSGKLVYTIAKNPNDYPTSVVRGDDNFREGLFIDYRHFDNARIEPRFEFGFGLSYTNFSYSNLGISSSATAGPATGPTIPGGPADLWDYVATVTATITNTGGVEGAEVAQLYISLPSSAPATPPKQLRGFAKLKLAPGQSRTATFRLRKRDLAYWDVRRQNWVVPSGRFGVLVGASSRDIRLQGEIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGH8</accession>
    <name>G0SGH8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">60S ribosomal protein L12-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0066380</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="476" last="476">
            <title>High-resolution structures of a thermophilic eukaryotic 80S ribosome reveal atomistic details of translocation.</title>
            <authorList>
                <person name="Kisonaite M."/>
                <person name="Wild K."/>
                <person name="Lapouge K."/>
                <person name="Ruppert T."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="35079002"/>
            <dbReference type="DOI" id="10.1038/s41467-022-27967-9"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.90 ANGSTROMS)</scope>
    </reference>
    <reference evidence="14 15 16" key="3">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e56910" last="e56910">
            <title>Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation during pre-60S biogenesis.</title>
            <authorList>
                <person name="Lau B."/>
                <person name="Huang Z."/>
                <person name="Kellner N."/>
                <person name="Niu S."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
                <person name="Cheng J."/>
            </authorList>
            <dbReference type="PubMed" id="37129998"/>
            <dbReference type="DOI" id="10.15252/embr.202356910"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <reference evidence="18 19 20" key="4">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e57984" last="e57984">
            <title>Structural insights into coordinating 5S RNP rotation with ITS2 pre-RNA processing during ribosome formation.</title>
            <authorList>
                <person name="Thoms M."/>
                <person name="Lau B."/>
                <person name="Cheng J."/>
                <person name="Fromm L."/>
                <person name="Denk T."/>
                <person name="Kellner N."/>
                <person name="Flemming D."/>
                <person name="Fischer P."/>
                <person name="Falquet L."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="37921038"/>
            <dbReference type="DOI" id="10.15252/embr.202357984"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.12 ANGSTROMS)</scope>
    </reference>
    <reference evidence="12 13" key="5">
        <citation type="journal article" date="2023" name="Nat. Struct. Mol. Biol." volume="30" first="670" last="677">
            <title>Structural inventory of cotranslational protein folding by the eukaryotic RAC complex.</title>
            <authorList>
                <person name="Kisonaite M."/>
                <person name="Wild K."/>
                <person name="Lapouge K."/>
                <person name="Gese G.V."/>
                <person name="Kellner N."/>
                <person name="Hurt E."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="37081320"/>
            <dbReference type="DOI" id="10.1038/s41594-023-00973-1"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.20 ANGSTROMS)</scope>
    </reference>
    <reference evidence="17" key="6">
        <citation type="journal article" date="2024" name="Nat. Commun." volume="15" first="716" last="716">
            <title>Methionine aminopeptidase 2 and its autoproteolysis product have different binding sites on the ribosome.</title>
            <authorList>
                <person name="Klein M.A."/>
                <person name="Wild K."/>
                <person name="Kisonaite M."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="38267453"/>
            <dbReference type="DOI" id="10.1038/s41467-024-44862-7"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.10 ANGSTROMS)</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696935.1">
        <property type="nucleotide sequence ID" value="XM_006696872.1"/>
    </dbReference>
    <dbReference type="PDB" id="7OLC">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="LK=1-165"/>
    </dbReference>
    <dbReference type="PDB" id="7OLD">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="LK=1-165"/>
    </dbReference>
    <dbReference type="PDB" id="7Z3N">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="LK=1-165"/>
    </dbReference>
    <dbReference type="PDB" id="7Z3O">
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        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
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    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="10 11 12" id="KW-0002">3D-structure</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="7">
        <location>
            <begin position="13"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="6">
        <location>
            <begin position="74"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGS17317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="7OLC"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="7OLD"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PDB" id="7Z3N"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PDB" id="7Z3O"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="8I9T"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="8I9V"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="8I9W"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PDB" id="8OO0"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PDB" id="8PV1"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="19">
        <source>
            <dbReference type="PDB" id="8PV2"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PDB" id="8PV3"/>
        </source>
    </evidence>
    <sequence length="165" mass="17773" checksum="7B2A8A5293083BA7" modified="2011-10-19" version="1">MPPKFDPNEIKIIHLRATGGEVGASSALAPKIGPLGLSPKKVGEDIAKATADWKGLRVTVRLTIQNRQAQVSVVPTASALIIRALKEPPRDRKKEKNIKHNKSVSLDEIIEIARTMRFKSFSKDLKGGVKEILGTAFSVGCQVDGKSPKAISDAIEAGEIDIPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGN7</accession>
    <name>G0SGN7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0067010</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006696931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGN7"/>
    <dbReference type="STRING" id="759272.G0SGN7"/>
    <dbReference type="GeneID" id="18260739"/>
    <dbReference type="KEGG" id="cthr:CTHT_0067010"/>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_1_1"/>
    <dbReference type="OMA" id="YHKHGME"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19077">
        <property type="entry name" value="AKR_AKR8A1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF78">
        <property type="entry name" value="PYRIDOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="13"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="333" mass="36152" checksum="62717268BF0DDEE1" modified="2011-10-19" version="1">MVHAIHGKQVGDIGYGLMGLTWRTDPLPDDQAFAAIKAALAAGCNYFNGGEFYGPPDNNSLTLLNKYLEKYPEDADKFVLNVKGCIKLPSFAPDGTPEGVKASVDNCVRMLGGKGKIHQFEPARKDPNVEIETTIAALKEQVDSGLVGGISLSEVSAATLRRAAKLAKIESVEVELSLWETSPLENGLAEACAELDIPILAYSPLGRGFLTGKLKSPDDIPEGDFRKLLPRFQPGAFEKNLELVHEVEKLAARKGCTPAQVAIGWLLALSKRPGMPRIIPIPGASSPERIRENSTVVELSEEDMAEIERIRKGFPVVGERYHKHGMEVLDNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHK0</accession>
    <name>G0SHK0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2423 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0070290</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="5 6 7" key="2">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e56910" last="e56910">
            <title>Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation during pre-60S biogenesis.</title>
            <authorList>
                <person name="Lau B."/>
                <person name="Huang Z."/>
                <person name="Kellner N."/>
                <person name="Niu S."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
                <person name="Cheng J."/>
            </authorList>
            <dbReference type="PubMed" id="37129998"/>
            <dbReference type="DOI" id="10.15252/embr.202356910"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <reference evidence="8 9 10" key="3">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e57984" last="e57984">
            <title>Structural insights into coordinating 5S RNP rotation with ITS2 pre-RNA processing during ribosome formation.</title>
            <authorList>
                <person name="Thoms M."/>
                <person name="Lau B."/>
                <person name="Cheng J."/>
                <person name="Fromm L."/>
                <person name="Denk T."/>
                <person name="Kellner N."/>
                <person name="Flemming D."/>
                <person name="Fischer P."/>
                <person name="Falquet L."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="37921038"/>
            <dbReference type="DOI" id="10.15252/embr.202357984"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.12 ANGSTROMS)</scope>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17689.1"/>
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        <property type="nucleotide sequence ID" value="XM_006697244.1"/>
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        <property type="resolution" value="2.55 A"/>
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        <property type="resolution" value="2.19 A"/>
        <property type="chains" value="CO=1-120"/>
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    <dbReference type="eggNOG" id="ENOG502SXGY">
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    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="DUF2423"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28219">
        <property type="entry name" value="UPF0642 PROTEIN YBL028C"/>
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    </dbReference>
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        <property type="entry name" value="UPF0642 PROTEIN YBL028C"/>
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    </dbReference>
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    </dbReference>
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    <feature type="domain" description="DUF2423" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PDB" id="8I9T"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PDB" id="8I9V"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PDB" id="8I9W"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PDB" id="8PV1"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="8PV2"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="8PV3"/>
        </source>
    </evidence>
    <sequence length="120" mass="13231" checksum="849B234C686EDB60" modified="2011-10-19" version="1">MAKSARASRIKENHQRFKKNIAGPVEAARLERLSAKLMAIAQAPKPDIEMKEESEATAEQPKESTQTKDDTAMDVDGAKPTLSGVKSGKSIGRKDSRKRRGKKSSIVFPMKGPKRNNLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G0SI66</accession>
    <name>G0SI66_CHATD</name>
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        <recommendedName>
            <fullName evidence="6">Nitronate monooxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0074680</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
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        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17136.1"/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SI66"/>
    <dbReference type="STRING" id="759272.G0SI66"/>
    <dbReference type="GeneID" id="18261506"/>
    <dbReference type="KEGG" id="cthr:CTHT_0074680"/>
    <dbReference type="eggNOG" id="ENOG502RHJM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038732_9_0_1"/>
    <dbReference type="OMA" id="FGWPEEY"/>
    <dbReference type="OrthoDB" id="2349068at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF34">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS17136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="37887" checksum="06CD2DD1BA90BB8C" modified="2011-10-19" version="1">MANKLQSIALRGALLAAYPWTVAPLIVSAPMRVMSGPDLAVAVSRAGGLGFIGPGAKPEDTAADLETARKLLAAFEPFTATQASVLPIGIGFQVWNGNLDVAASTVAQYKPAAVWLFAPRNGQADIDNWTKRLRGVSPSSKIWLQIGTLKEALDAVRSATPPDVLVVQGAEAGGHGRAKDAIGFITLLPEIADATKDSGIPLIAAGGIADGRGVVAALGAGAAGVAMGTRFLACNEARIKKGYQDEVVRATDGGANTVRTHLYNHLRGTFGWPEQWSPRTIINRSWLEQQAGMPFEEIKKHHDEAVSKGDAVWGPDGWTATYASASIGLIRSVEAAGTIVENVRKEASEIVQMLHVLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G1DJB0</accession>
    <name>G1DJB0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Cytochrome c oxidase subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_m000530</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="12"/>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:11437"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome c oxidase subunit 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="JN007486">
        <property type="protein sequence ID" value="AEI26018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004769791.1">
        <property type="nucleotide sequence ID" value="NC_015893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G1DJB0"/>
    <dbReference type="STRING" id="759272.G1DJB0"/>
    <dbReference type="GeneID" id="11030342"/>
    <dbReference type="KEGG" id="cthr:CTHT_m000530"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01665">
        <property type="entry name" value="Cyt_c_Oxidase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000082">
        <property type="entry name" value="Cytochrome c oxidase subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.80:FF:000002">
        <property type="entry name" value="Cytochrome c oxidase subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.80">
        <property type="entry name" value="Cytochrome c oxidase, subunit III, four-helix bundle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024791">
        <property type="entry name" value="Cyt_c/ubiquinol_Oxase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033945">
        <property type="entry name" value="Cyt_c_oxase_su3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035973">
        <property type="entry name" value="Cyt_c_oxidase_su3-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013833">
        <property type="entry name" value="Cyt_c_oxidase_su3_a-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11403:SF7">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11403">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00510">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81452">
        <property type="entry name" value="Cytochrome c oxidase subunit III-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="199"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Heme-copper oxidase subunit III family profile" evidence="11">
        <location>
            <begin position="10"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AEI26018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="269" mass="29956" checksum="ECD4A92D1CF60DE1" modified="2011-10-19" version="1">MTNLIRSNFQDHPFHLVSPSPWPLFTSISLLNLATSAALSMHNFNNGYILTILSLILVISSMSFWFRDVISEGTFLGNHTLAVQKGLNIGIILFIVSEALFFLAIFWAFFHSAMAPSVELGGQWPPLGIEPVNPFELPLLNTVILLSSGATITYGHHSLIHGDRKGALYGTIATVLLAIIFTVFQGIEYNVSSFTISDGAFGTCFFFGTGFHGFHVIIGTIFLSVALWRVFDYHLTDNHHVGLEGGILYWHFVDVVWLFLYIAVYYWGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>G0RXT3</accession>
    <name>G0RXT3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">CTHT_0000300</name>
    </gene>
    <organism evidence="25">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="GL988030">
        <property type="protein sequence ID" value="EGS24099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690585.1">
        <property type="nucleotide sequence ID" value="XM_006690522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RXT3"/>
    <dbReference type="SMR" id="G0RXT3"/>
    <dbReference type="STRING" id="759272.G0RXT3"/>
    <dbReference type="DNASU" id="18254068"/>
    <dbReference type="GeneID" id="18254068"/>
    <dbReference type="KEGG" id="cthr:CTHT_0000300"/>
    <dbReference type="eggNOG" id="KOG1027">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004875_2_0_1"/>
    <dbReference type="OMA" id="QCYEKDY"/>
    <dbReference type="OrthoDB" id="63989at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990604">
        <property type="term" value="C:IRE1-TRAF2-ASK1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070059">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036498">
        <property type="term" value="P:IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09769">
        <property type="entry name" value="Luminal_IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10422">
        <property type="entry name" value="RNase_Ire1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000077">
        <property type="entry name" value="Putative Serine/threonine-protein kinase/endoribonuclease IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000572">
        <property type="entry name" value="Serine/threonine-protein kinase/endoribonuclease IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.180:FF:000002">
        <property type="entry name" value="Serine/threonine-protein kinase/endoribonuclease IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.180">
        <property type="entry name" value="KEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045133">
        <property type="entry name" value="IRE1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010513">
        <property type="entry name" value="KEN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038357">
        <property type="entry name" value="KEN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_b-propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954">
        <property type="entry name" value="IRE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954:SF6">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06479">
        <property type="entry name" value="Ribonuc_2-5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00580">
        <property type="entry name" value="PUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51392">
        <property type="entry name" value="KEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8 21" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408756" description="non-specific serine/threonine protein kinase" evidence="21">
        <location>
            <begin position="38"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="811"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="domain" description="KEN" evidence="23">
        <location>
            <begin position="1114"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="38"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="536"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="664"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="550"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="693"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="715"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="733"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="753"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="839"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EGS24099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1250" mass="138603" checksum="6D4FA8C63743413B" modified="2011-10-19" version="1">MLRRPPGHVAPPRPRQRNKYLLALALILLPWLPLADAQQQHPPAGRPPSPLRDPGTPAAYHVRSPSPPEDDQHAAPNLAATTVTADGTAAVHARRTSVSGYVDDEIARSHLRALASRSTYNIPDDVRAHALAPDLSVRAPPPSHYRGSSVPGGAGLSQHLARSLEDWEVEDFVLLATVDGDLIASDRKTGQERWHFKADQPLVETRHFRTNRSVLDEDFDPIDHYIWVVEPTRDGELYLWRPHENGAGLAKMAWTMKKVVEELSPYDDKINGVVYTGDKRTTMITLNALTGTVIKEFGSTGSYVNKVESESCFKPNALADREEECSDDPTITLGRTEYSVIIHRADGSPIASLKYSEWGPNTQDNDLLQQNIISKDSRYITGQHDGKVYGFDYGRFSEERPLFTKTLSSPVARVFDVLRRIGDPPGGNPELIVLPQPPLPVTDEENLRLRSEKVFINQTEQGGWYALSALRYPLIMSAPAAAIHRLDWWKIKGAWDLLSDQQKSSVLVGTHNLPSAIGTVERPESQRLLLDAPRETDKPVAVEPKLPLEPELPPLLPPPQPEPSRIFETAKRIPEIAAIKVIDLISNPAAIVLFFVSLWLVYKDRILSWKHQQWDKRVSALVSKIQVTPTVSEPALVQPQSAHSDAAQASSQQEIAIVPEAGETKAESPFASAPAATQPTTIELPQEPEKTAQPPSQDSGTPDSAVSRTSPSTESAQPAAEGADGAASAEPVKKKKAHRGRRAGVKHRKGPKKNAANNDAAQADPTQQAVEEVVNKAKSLVREPKLEPDIITAGAGDEVSGHILKMGLLEVNEAEPLGTGSNGTIVFAGKWDGRDVAVKRMLVQFNEIASQETRLLRESDDHPNVIRYYAQQERADFLYIALELCEASLADIVQRPHCYRELAQAGERDMPGVLWQIANGLAHLHSLRIVHRDLKPQNILVNMGKDGKPRILVSDFGLCKKLEGGQSSFGATTAHAAGTSGWRAPELLIDDDVPGSSALALTDPGSSLHSASGSGHPENPVISHHRRVTRAIDIFSLGLVYFYVLTRGNHPFDCGDRFMREVNIRKGNYNLSALDALGDFAYEARDLISSMLNANPKLRPTARDVMAHPFFWTYKKRLSFLCDVSDHFEKEPRDPPSPALQELESHAPDVVRGDFLKHLPREFVESLGKQRKYTGSRLLDLLRALRNKRNHYEDMSDSLKKMVGRLPDGYLRFWATRFPNLLIVCWNVVYDLHWDDTDRFRDYYQPAPPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0RXU2</accession>
    <name>G0RXU2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">CTP synthase</fullName>
            <ecNumber evidence="3 12">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0000390</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>UTP + L-glutamine + ATP + H2O = CTP + L-glutamate + ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CTP synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="3 12"/>
    <dbReference type="EMBL" id="GL988030">
        <property type="protein sequence ID" value="EGS24108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690594.1">
        <property type="nucleotide sequence ID" value="XM_006690531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RXU2"/>
    <dbReference type="STRING" id="759272.G0RXU2"/>
    <dbReference type="GeneID" id="18254077"/>
    <dbReference type="KEGG" id="cthr:CTHT_0000390"/>
    <dbReference type="eggNOG" id="KOG2387">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011675_5_0_1"/>
    <dbReference type="OMA" id="EFNNAYR"/>
    <dbReference type="OrthoDB" id="1739076at2759"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097268">
        <property type="term" value="C:cytoophidium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000207">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000005">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003792">
        <property type="entry name" value="PRK05380.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="CTP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550:SF0">
        <property type="entry name" value="CTP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP synthase N-terminal" evidence="14">
        <location>
            <begin position="2"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase" evidence="13">
        <location>
            <begin position="314"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU810713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS24108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="580" mass="64171" checksum="85BE339417182B60" modified="2011-10-19" version="1">MRYVLVTGGVISGVGKGIIASSTGLLLKTLGLRVSCIKIDPYVSVDAGLMAPAEHGECFVLCSGSEVDLDLGNYERYLSVRLTGEHNITTGKVYLNVIEKERRGDYLGKTVQIVPHVTDSIKDWIRRVSKIPVDGTGEEPHVCIVELGGTIGDIESMPFIEALTQLRHEAGPGNFMNIHVSYVPTVHGEQKTKPTQHAVKSIRSHGLIPDVIACRCEQPLSPATLAKLALHCQVEPEQVIVVRDMPTIYQVPLLLSEQKLIPLLRSKLALDKIEITPAMEAQGTGLWNTWKDVVTPTYQEELKIALVGKYVTCQDAYLSVVKALEHSAMRIRRKLQILWIDSEDLEPTSKGGPAQAKYHKAWHEVSTASGIIVPGGFGHRGTEGMMRVTKWARENDVPFLGVCLGFQVAAIQYARDLCGLPDATSEEFDAQAKTHIVVNMPELDKKNMGGTMRLGLRKTVFQPNTEWSKARALYGNVDVIEERHRHRYEINPKYVDMLEKAGLHFVGRDETGERMEVFELKDHPFFIGTQFHAEYQSQVVNPSRPYLGFVAASAGCLDAVLPQEPVQPFKAPVIVNGTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYC9</accession>
    <name>G0RYC9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP synthase subunit beta</fullName>
            <ecNumber evidence="14">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CTHT_0006240</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="14"/>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691157.1">
        <property type="nucleotide sequence ID" value="XM_006691094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYC9"/>
    <dbReference type="STRING" id="759272.G0RYC9"/>
    <dbReference type="GeneID" id="18254662"/>
    <dbReference type="KEGG" id="cthr:CTHT_0006240"/>
    <dbReference type="eggNOG" id="KOG1350">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022398_0_2_1"/>
    <dbReference type="OMA" id="SMEEGGW"/>
    <dbReference type="OrthoDB" id="14523at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18110">
        <property type="entry name" value="ATP-synt_F1_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18115">
        <property type="entry name" value="ATP-synt_F1_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01133">
        <property type="entry name" value="F1-ATPase_beta_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000001">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.170:FF:000004">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000026">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050053">
        <property type="entry name" value="ATPase_alpha/beta_chains"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184">
        <property type="entry name" value="ATP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184:SF71">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039072">
        <property type="entry name" value="ATPase_subunit_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 14" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 14" id="KW-0139">CF(1)</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="191"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGS23915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="524" mass="56320" checksum="4B01CA93A5DB3403" modified="2011-10-19" version="1">MFKSGISAFARTARPSFAAATRRAVRPAPLLNLRAPLLSRFASTQQNKGVGEGKIHQVIGAVVDVKFDTDKLPPILNALETTNNGQKLVLEVAQHLGENVVRCIAMDGTEGLVRGAKAVDTGAPITIPVGPATLGRIMNVTGDPIDERGPIVTDKYAPIHADPPEFVEQSTEAEILVTGIKVVDLLAPYARGGKIGLFGGAGVGKTVFIQELINNIAKAHGGYSVFTGVGERTREGNDLYHEMQQTSVIQLDGESKVALVFGQMNEPPGARARVALTGLTIAEYFRDHEGQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLAVDMGAMQERITTTKKGSITSVQAVYVPADDLTDPAPATTFAHLDATTVLSRGISELGIYPAVDPLDSKSRMLDPRIVGQEHYEVATRVQQILQEYKSLQDIIAILGMDELSEADKLTVERARKIQRFLSQPFTVAQVFTGIEGKLVDLKDTIASFKAILNGEGDDLPEAAFYMVGDFQSAKEKGAKILAELEKSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYJ2</accession>
    <name>G0RYJ2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CDP diacylglycerol-inositol 3-phosphatidyltransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0006890</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691220.1">
        <property type="nucleotide sequence ID" value="XM_006691157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYJ2"/>
    <dbReference type="STRING" id="759272.G0RYJ2"/>
    <dbReference type="GeneID" id="18254727"/>
    <dbReference type="KEGG" id="cthr:CTHT_0006890"/>
    <dbReference type="eggNOG" id="KOG3240">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067602_0_1_1"/>
    <dbReference type="OMA" id="GISFPIM"/>
    <dbReference type="OrthoDB" id="10251079at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003881">
        <property type="term" value="F:CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000011">
        <property type="entry name" value="Cdp-diacylglycerol-inositol 3-phosphatidyltransferase pis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF4">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--INOSITOL 3-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS23978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="305" mass="33668" checksum="64DF6D4F4B0BDE1C" modified="2011-10-19" version="1">MAGAKSRRQGPSQEKEDIPVNGSAHIEAKDAADDEPRENIFWFWPNIIGYSRIILAVASLYYMPLHPRTCSLLYSVSCLLDALDGYAARYFEQSTRFGAVLDMVTDRCTTACLLVFLSSAFPRWAILFQGLISLDLASHYMHMYATLAMGGADQSHKSVDKSRSRILSLYYTNKTVLFMACALNEAFFIALYLLSFSSPLLSPSLLQQVPDQAAAAIQQGAQVNTSLLSQLFGPSPYSAAALELARANKIDSFWPWVLAAVSFPVMALKQIINVVQLVKASKWLAEGDIRARRAAGLPRKKAKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYK1</accession>
    <name>G0RYK1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protamine P1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0006980</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006691166.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0RYK1"/>
    <dbReference type="GeneID" id="18254736"/>
    <dbReference type="KEGG" id="cthr:CTHT_0006980"/>
    <dbReference type="eggNOG" id="ENOG502SYKX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_286072_0_0_1"/>
    <dbReference type="OMA" id="SDSLECH"/>
    <dbReference type="OrthoDB" id="5419922at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="852"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="433"/>
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        </location>
    </feature>
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        <location>
            <begin position="517"/>
            <end position="533"/>
        </location>
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            <begin position="550"/>
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    </feature>
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            <begin position="585"/>
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        </location>
    </feature>
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        <location>
            <begin position="676"/>
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        <location>
            <begin position="852"/>
            <end position="862"/>
        </location>
    </feature>
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        <location>
            <begin position="872"/>
            <end position="896"/>
        </location>
    </feature>
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        <location>
            <begin position="941"/>
            <end position="952"/>
        </location>
    </feature>
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        <location>
            <begin position="967"/>
            <end position="984"/>
        </location>
    </feature>
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        <location>
            <begin position="985"/>
            <end position="994"/>
        </location>
    </feature>
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        <location>
            <begin position="1092"/>
            <end position="1101"/>
        </location>
    </feature>
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        <location>
            <begin position="1111"/>
            <end position="1122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1300" mass="141429" checksum="9C2C63B87ED50441" modified="2011-10-19" version="1">MSQSFPWLQPMSVNVEPLRCDPLHGPEDVIYSGSDDDAYSDPEERSRRVETQALRYLEGKSVFLLSTSLRGPFDSSSGWVNPWRSRSASRVDKHKRTSKWLSRPKQTAASLRTSQDHNVSSHTFESANSNAANLASFKTTNIQYEEDYDNLQGPLQYLDEDALYRIEAWRQRVAREFSVRTPGHSAPQTPTSADSRKAIQWTVRTPGSSSRIVCDEIPQSSFVLPPSTPVQASKQESRSLSKSKTFHQPNEPGPSSLLPAASQPQAVHSTPQSATLPKPTAAIDLSPHAVKLYEQFVMAGKSSAHSPVRAPQGVEPPGEDTPVKEEPREPSLEDIQGVASQAYATPDVLPDHPVSAIRYQLQYSTQTDGSFRFRRKRSAPSGDDSRPTSPGSEQRPASRRESGPTLEQHQVSEEQPEVAGPELEVLKQALPPGDDHPRLEQESTRPEPESQVKIEPPEDQSREVSMSSEHIPDTEPQTVGTVPEQIGPENALEDNFPSPEQQVGAPAAAEALLQGSEPRDQTPESEPEQKEGDATSTPPAVHEPIAGPNDVTQQTPSEATPRPNSAQRSVQRTSGSSPVACPAQQAETYTPAASVSQLDGPTLIATGDSFASSEPSSFAYFSQEGFSQDMPSKVLPSPRRLLWPRSQRASNSPGPLFGFASIPAKNQTQAVQAGPEENHVVQDKNDAIEPVVADRDAPTETNEDGNDVTPTATVAQYSGSETASEAEEENVHPEEPPQPEEANDEPETRRPSSVPEPAAQSPWIKEEAIPPPPAPETVQEAEPAEPKVARTPQAVQSPWTKDDSILSALGALQNPRLSLIANQGLVNTASQSPWARGDSQIPSLVARMVNPLSSPANSSILPENTELEAEYSLSQNPEQQPQSLCKLRVQNTTMPDSQGGEADSLPPQPSTPETKPSSLPTPPDFSISVRSFKEFMTPSPRPKRAMKRRRTSLHYTDRKSDEDTSELLPSTQALVDAATTNPWQSSSALRPSSSMPCTAKSENRGIKRRRKKRVSWADLEGQNLCQEEGGDSQAETETASCVAREKLSRRASSPPPSILSRAKLPGEGEKFGKHFAAVSRRRRGVGSTDQVPSSQQSTPQPEENALPQEADPSEDKDDDEDSNKENITPEPLDEPNPLEVSTELEESSQSPSHHSSEIDSENEENIDPNQLSQELDTQLDDVNAVLQNLDEFLGTSWDLDAELRSMARQQRQIEQQSRVGFGLEMGDSISTISDTAKRESVNFGFNSGVGDEEQDVPASSAVFGSGEFVSGFAGASRRRSGRGSGFGLGFDDMMDAGVWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYQ5</accession>
    <name>G0RYQ5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0007520</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS24041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691283.1">
        <property type="nucleotide sequence ID" value="XM_006691220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYQ5"/>
    <dbReference type="GeneID" id="18254790"/>
    <dbReference type="KEGG" id="cthr:CTHT_0007520"/>
    <dbReference type="eggNOG" id="ENOG502T5TG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2133234_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS24041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="113" mass="11807" checksum="BEA2FE74771E0C36" modified="2011-10-19" version="1">MKNNDTLALIIIAYIVFTILIFVAVFHFARSFFGATVAKSSSSSSSGSSSSSSSSSGSSSSDSSFSHSEPEFVTQPISESRISGLQAATNMFPPAPPGAFAPVPAPQVQQQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYV2</accession>
    <name>G0RYV2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0000680</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006690559.1"/>
    </dbReference>
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    <dbReference type="STRING" id="759272.G0RYV2"/>
    <dbReference type="GeneID" id="18254106"/>
    <dbReference type="KEGG" id="cthr:CTHT_0000680"/>
    <dbReference type="eggNOG" id="KOG1676">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025201_0_0_1"/>
    <dbReference type="OMA" id="QNTTGCK"/>
    <dbReference type="OrthoDB" id="5204190at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="196"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="291"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="387"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="111"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="458"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="141"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="366"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="482"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS23380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="553" mass="59387" checksum="2B372A1B574B0363" modified="2011-10-19" version="1">MANSTPDISSILRLLDATQRPASSAPAQTQPGVPAPATASAPLPSNPYATSVPNPYPSQTGTYQPPVAYQYPQPASSGSIDLSSIRPVNSGTVPLADAIAKAKAYATEQGFTPYDRQSGSYSDSRANDSRQYSRSRSKSPRGRDPYRDNYNPYRDERRADHGRDYGRERSYSPGRGRAFSPRGSHGGRERSPLRNKDDVEVIEIEASLVGLIIGRQGENLRRVEGETRCRVQFIPPQGPNDQMRLCKIQGPRPQREEAKEMINRIIRDSGMRGPGERGRDGGRGPPAPKEGEDTVQIMVPDRTVGLIIGRGGETIRDLQERSGCHINIVGENKSVNGLRPVNLIGPPAATRIAKELILEIVDSDSRNGNLPNPRGGRNDNFGGNGQEKVNDSIFVPSDAVGMIIGKGGETIREMQNMTGCKINVSQPSGPGEVEREIGLVGTREAIARAKRAIEDKVEVVRQKSGSGRGRGQHRDYDNPNYGQSSNTNSTPSTTAAGAATQSSAGSSTANPADPYAPYGGYENYIALWWQSQLAAQAAQAQAQGATSQAPGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYW6</accession>
    <name>G0RYW6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0000820</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690636.1">
        <property type="nucleotide sequence ID" value="XM_006690573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYW6"/>
    <dbReference type="GeneID" id="18254120"/>
    <dbReference type="KEGG" id="cthr:CTHT_0000820"/>
    <dbReference type="eggNOG" id="ENOG502SISJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025894_2_0_1"/>
    <dbReference type="OMA" id="HATFWVY"/>
    <dbReference type="OrthoDB" id="10027823at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520:SF5">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="98"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="205"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS23394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="398" mass="42753" checksum="872A2E1D46F602A7" modified="2011-10-19" version="1">MSSEPQPSLLCRLLSSTGLQALYQIGLDAHLIILSRSSRMLAYGGSSLILALFFSSLHVPDARIGLFMTLTLAGDVALSLGLALIADRVGRRRILKTGSVLMILSGVVFALCENYWVLLGAAILGVISATGGDFGPFRAIEESVVSGLAKKEERTDVLVWCELKPAGTSEGDEERRPLLNESQNDDSSSSGKHYKSWISRISRETLSIMSILWFLLMVDSLADGMANMSLTSYYLDQKFSLLKSVLGNIVSTSYLLAAVATIFASPLSRALGLVNTMVFTHIPSSAAVLLFPLPRGVVITFALLLVRMGLNNMDQAPRAALIAATVRPDERTAVMGITGMLRTLASTTGPIITGVLAEGGNFWAAFVVAGALRLAYDVGLFAMFINIKLHKDEEDESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYZ9</accession>
    <name>G0RYZ9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0001160</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690669.1">
        <property type="nucleotide sequence ID" value="XM_006690606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYZ9"/>
    <dbReference type="GeneID" id="18254154"/>
    <dbReference type="KEGG" id="cthr:CTHT_0001160"/>
    <dbReference type="HOGENOM" id="CLU_1578338_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="169" mass="18738" checksum="DF4A78E742B23CAF" modified="2011-10-19" version="1">MITRISHRHFTALAQRQATALQSSILRESLPARRLLATTAPRRQQPPKTYFDDGSQPKPYFTEESKPKTYFTSESTTEPPVKTYFSDTTPSPQAPVQTYFTDSSPVPPTAPPQLDPAAEPKPKKKRRLLPRLLFAAFFTTLGAAVGWAALNIVIPAPPAEPDSPSRHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZ57</accession>
    <name>G0RZ57_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[histone H3]-trimethyl-L-lysine(9) demethylase</fullName>
            <ecNumber evidence="2">1.14.11.66</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0001780</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 2-oxoglutarate + 2 O2 = N(6)-methyl-L-lysyl(9)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:60200"/>
            <dbReference type="Rhea" id="RHEA-COMP:15538"/>
            <dbReference type="Rhea" id="RHEA-COMP:15542"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="1.14.11.66"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the JHDM3 histone demethylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.66" evidence="2"/>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690727.1">
        <property type="nucleotide sequence ID" value="XM_006690664.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0RZ57"/>
    <dbReference type="GeneID" id="18254216"/>
    <dbReference type="KEGG" id="cthr:CTHT_0001780"/>
    <dbReference type="eggNOG" id="KOG0955">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0958">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001442_4_2_1"/>
    <dbReference type="OMA" id="PWGGFTN"/>
    <dbReference type="OrthoDB" id="9547406at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051864">
        <property type="term" value="F:histone H3K36 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140684">
        <property type="term" value="F:histone H3K9me2/H3K9me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15571">
        <property type="entry name" value="ePHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000024">
        <property type="entry name" value="Putative jumonji family transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055500">
        <property type="entry name" value="DUF7072"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF7">
        <property type="entry name" value="[HISTONE H3]-TRIMETHYL-L-LYSINE(9) DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23258">
        <property type="entry name" value="DUF7072"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjN" evidence="9">
        <location>
            <begin position="133"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="10">
        <location>
            <begin position="399"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="654"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="223"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="582"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="949"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1033"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1165"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1240"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1309"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="84"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="232"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="585"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="621"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="973"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1067"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1092"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1136"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1169"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1261"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1316"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1359"/>
            <end position="1452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS23485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1548" mass="170592" checksum="3562C5C1AD9514F6" modified="2011-10-19" version="1">MSIEAIGATAPTAALDAKLSSSSDSGSSSKDLGLNSPPDSNGADAMDVDNSDSELSDLDDIASKLDGVIGDLDIEQKCQEVESAEKMEVEKAVLIEAKDDATKEDANKEAQKEIEEEEEDIGEIEPDHWTGGVPVFKPSYRQFKDFKRFMEAVDKYGMQSGIIKIVAPEEWKNSLPPIDDLIKRIRVRDPIKQEIMGHNGTYRQINILHQRTYTLKQWKQLCDQSEHQPPARRGERRANADQKPPRTRAAVAAAAATAAGPSRPVTRSTAAATPTKKGRGCRVTRQSAKLAKHDDEELEERPMTPVSPEAEKEEVLDSIGQEAEEAKEGGAIARRKRTARGRREGSVVIDEEHFKDFDYNMDISDFTPERCEELEKIYWKTLTYAPPMYGADLPGTLFDESVEIWNLNKLPNLLDVLGTKVPGVNTAYLYLGMWKATFAWHLEDVDLYSINYLHFGAPKQWYSIPQKDARRFEAAMKSIWPQEAKACDQFLRHKGFLISPSHLKQHYNITVNKCLSYPGEFVVTYPYGYHSGFNLGYNCAEAVNFALDTWLPMGKIAKKCECAQAQDSVWVDAWEIERKLRGEESEYEETEDEEDEVDEVGDEDEEVETGLPSPPSDHTAKVKLPRRKRKRAEGEEAEPRVKKKIRVRQKPHAEQPCCLCPNDIPGAEILDTDDGRKAHRMCGLYIPETYVETVGGKEIIANVANIDKARLELKCLYCRSKKGACFQCSHKKCPRAYHATCAAAAGVFVEEGEVPVFGEDGTEYKEQAFEFSCRFHRTKRDRKFEGDALENDPEIRKAAKALKKNDICQLQFYRGDIFAGVVVENHLDEETLLIDVIPNGDRVEVEWKWLLLPDPADFRLPKASPNAIPLPTCRKAQKAINAKRTDDEVPRKDEEFGPGYVWAEFSTCEPFRNRAQTKVDLSKENQIWYYLGETSTDAKAQYTENPAIKRHNPKSNFLESLPKPVVAPTPILGAPPPPPPPPPPPPPQQQQQQQQQTGDVLALKQEKPYLYKPKIPVAPAAGTQAGYATQTFTSVPASGPFPPQPSPAQANKPSTMSMYHHHGSPQGGQKEQPQQQQCPPNMQYQQPPQQPKNSSSLFSSTDRFAPVGGSNGFPTLPGLTWPPAHMKSGHHHHPQQQHYGLQQPQSRVGVAQTTANMPPLVPMTSSHLQPQYGAQQQVPGGAQQQQPQPAMCAYQKYSFFQLNHNRDPSRYRTPYGQWGGFVNGYEGNLREFLLRAQKALNGGSSSKGPKPLVSAQTTGYPQTLPRPQQPQQSVLAPAPAPASAQQAGGQPLHPAIRMPYGVAPAQAQSQAQVPIAPSPTPMQAPAPAPASVPAKEKIKQPFHKQSTSPIPLPPYVREMQMAAKAAQQGKAGAQATTQQPSTSVPASNQAQIQPASAAATTSTPQPALPQSPVQTPTSTTASPTQEKAQPNQASSSAAAATQNTPPQTHPQAYPSPPESKEPGQQGQRDTDVDKSRSVSTMELTAASGIEVEQKQEGQVQGRQLAQEDSQALVQKMMINLRRASLSLVEEADGQVSAIGSGAEDAASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZC7</accession>
    <name>G0RZC7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Kinetochore protein SPC25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0002500</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Chromosome</location>
            <location evidence="9">Centromere</location>
            <location evidence="9">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the SPC25 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690797.1">
        <property type="nucleotide sequence ID" value="XM_006690734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZC7"/>
    <dbReference type="STRING" id="759272.G0RZC7"/>
    <dbReference type="GeneID" id="18254288"/>
    <dbReference type="KEGG" id="cthr:CTHT_0002500"/>
    <dbReference type="eggNOG" id="KOG4657">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065188_0_0_1"/>
    <dbReference type="OMA" id="HEDQRMK"/>
    <dbReference type="OrthoDB" id="4056921at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23784">
        <property type="entry name" value="RWD_Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.457.50:FF:000001">
        <property type="entry name" value="Probable kinetochore protein spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.50">
        <property type="entry name" value="Chromosome segregation protein Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045143">
        <property type="entry name" value="Spc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013255">
        <property type="entry name" value="Spc25_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14281:SF0">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14281">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC25-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08234">
        <property type="entry name" value="Spindle_Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 9" id="KW-0137">Centromere</keyword>
    <keyword evidence="2 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="4 9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromosome segregation protein Spc25 C-terminal" evidence="12">
        <location>
            <begin position="179"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="55"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS23555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="255" mass="30051" checksum="6DC09CB1CB445E0D" modified="2011-10-19" version="1">MNMSSFEPSMSTSRPPLGSQSLADTLPKVNFGFDELRERMARFTAKFDAFIEQGRKRVLEERNEFRMNIAELQEDQRMKKKDIEIIQLKTNTYQQTIAKEAAETREMQQAIEQLTQQRDRQLAQRDALKEQIAAAQREIDARLAAQRAHAARLEEQARYNVPELDFWVTNLCLRIEGAGAPDRLKFVYTHIDERDWDREAWFELCMGGRDYNVKHCRPKLEREKVEKVLERVNETRELVVLLKGMRELFVEVMRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZD6</accession>
    <name>G0RZD6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0002590</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2025" name="Cell Res." volume="35" first="296" last="308">
            <title>Structural insights into spliceosome fidelity: DHX35-GPATCH1- mediated rejection of aberrant splicing substrates.</title>
            <authorList>
                <person name="Li Y."/>
                <person name="Fischer P."/>
                <person name="Wang M."/>
                <person name="Zhou Q."/>
                <person name="Song A."/>
                <person name="Yuan R."/>
                <person name="Meng W."/>
                <person name="Chen F.X."/>
                <person name="Luhrmann R."/>
                <person name="Lau B."/>
                <person name="Hurt E."/>
                <person name="Cheng J."/>
            </authorList>
            <dbReference type="PubMed" id="40016598"/>
            <dbReference type="DOI" id="10.1038/s41422-025-01084-w"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.90 ANGSTROMS)</scope>
    </reference>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690806.1">
        <property type="nucleotide sequence ID" value="XM_006690743.1"/>
    </dbReference>
    <dbReference type="PDB" id="9L5S">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="z=1-672"/>
    </dbReference>
    <dbReference type="PDB" id="9L5T">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.50 A"/>
        <property type="chains" value="z=1-672"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZD6"/>
    <dbReference type="EMDB" id="EMD-62842"/>
    <dbReference type="EMDB" id="EMD-62843"/>
    <dbReference type="SMR" id="G0RZD6"/>
    <dbReference type="STRING" id="759272.G0RZD6"/>
    <dbReference type="GeneID" id="18254297"/>
    <dbReference type="KEGG" id="cthr:CTHT_0002590"/>
    <dbReference type="eggNOG" id="KOG0922">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001832_5_11_1"/>
    <dbReference type="OMA" id="FHEVMET"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000020">
        <property type="entry name" value="ATP dependent RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001075">
        <property type="entry name" value="ATP dependent RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000767">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF136">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX35-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9 10" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="31"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="218"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS23564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="9L5S"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="9L5T"/>
        </source>
    </evidence>
    <sequence length="672" mass="74898" checksum="8CC0FB1C8B427F7E" modified="2011-10-19" version="1">MADSEVGGAFIPALYKPAALLPIAKHRESLLYLVETNPVTIVVGQTGSGKSTQIPQFLEKAGWCADGKLIAVTQPRRVAAVTLAIRVAEEFGCEVGKEVGYSIRFEDATSESTRIKYMTDGLLIREALVDPLLSRYSVIMIDEAHERSISSDILLGLLKKIRRKRPDLRIIISSATLQAEDYRAYFEKASETQEEDSSNDKQKESIASIISIEGRTYPIDILYLDTPTEDYLEKAISTVFDIHTNEPKGDILVFLTGRDEIEQAVQAVSERSASLPPGSEALLPLPLYSGLSAEQQMYVFEEAPENTRKVIFSTNLAEASVTIEGIVYVIDSGFVKLRAYNPKTGIESLTATPVSKASAAQRAGRAGRTKPGKCFRLYTEEAYQSLPDATVPEIQRSNLAPIILQLKALGIDNVLRFDYFTPPPAEQMTRALELLYSLGALDDYAKLTRPLGLRMAELAVEPMMAKTLLSAQSFGCLSEILTIAAMTSLDGTLWIQHEGDKKKTESVKRKFAAEEGDHLTLLNVYQAFVTKGRKEAHWCHENMLNYKAMIRAVSIRAQLKRFLERFGIDVEESLSSPSVSQQPANKAEKIQRCLTIGYFAHAAKMQPDGTFRNVSGTTVLHAHPSSIMFNRKADWVIFHEVLETKDKTFIRDITRIKKEWLLEYAPDFYKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZF2</accession>
    <name>G0RZF2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CTHT_0002750</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690822.1">
        <property type="nucleotide sequence ID" value="XM_006690759.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0RZF2"/>
    <dbReference type="GeneID" id="18254313"/>
    <dbReference type="KEGG" id="cthr:CTHT_0002750"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001037_0_0_1"/>
    <dbReference type="OMA" id="QLPGYTW"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000003">
        <property type="entry name" value="Histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000044">
        <property type="entry name" value="Putative sensor histidine kinase/response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000285">
        <property type="entry name" value="Putative sensor histidine kinase/response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000010">
        <property type="entry name" value="Sensor histidine kinase RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000579">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF46">
        <property type="entry name" value="HISTIDINE KINASE_RESPONSE REGULATOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="56"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="16">
        <location>
            <begin position="1976"/>
            <end position="2201"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="17">
        <location>
            <begin position="2276"/>
            <end position="2400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="467"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2205"/>
            <end position="2265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2407"/>
            <end position="2443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="484"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="2235"/>
            <end position="2245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="2411"/>
            <end position="2428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="2429"/>
            <end position="2443"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="13">
        <location>
            <position position="2331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGS23580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="2443" mass="270462" checksum="17E2697D2E80F60F" modified="2011-10-19" version="1">MDDSPLLDDQLLESPARVFERLRQIPGYTWDESRAPYHSTYDNWHVFGSRLVAPEPTRSATSGSHHHGSIASAVSVHASGYPVTPPVPPSFVPPSSRGSSTDQPPPLFIAHSDYLNSQRPIPTNSDDTNVVEQQVIARVSYHVLREERAFHTFKSLISSVDPEAEHIVKPIDLIRLPQQPGDRGPVIVAIYENPGPNYLFQCLDLGPAWYSAVKHSGRWEARPKRPPKLDAPLSLKTFLDFAIGAAQCLEVIHHGQGVSHGEVRGDAFHFNIETGKVKLVNFGAGLRSFEHSLTSTGWSSLSRELGVMHKLQYISPEQTGRTTAEPDTRTDIYSLGIVFWRLLTQQMVFQGETPLDIVQAVLSRRIPNVTAIRIDIPEVIGRIIQKCTAKNIADRYHSASGLRHDLVTVQKMLGNGELEGLKDWAIGTHDVSSTFRLPITMIGRERERDELVKIIERASRSHHVIRSSIIHHHHHTDGTGYAGDVSDSSSDYTRSSSRSNRRSAGSFSQSDSRAKFGQHASPPATDSGARSIATVSSGHSITRFHLPRPWDKSATGTLDGSDGVAPDMARFGNVAATTTDSSAASLSRHLSTAKFRKQGHCEVVLIEGPGGAGKSCLVQSVMADARRRGYCATAKFDRARKTPFEPLLKLLSSLFRQVQGERNTDSPFHQALRQYVRPVWPMLHKVLGLPEFLLPPVDPHASRGSISVSPGPAVNLDRRESVTPDILPPPSTPKAFPAQAGQSSREFLRTGTSTKSNRLMTTFLDVLRLFTHQKFICFCLEDLHYADDESLELISQIVAAKLKMVLILTYRPEDMSAEIVQRIVSPPRPEESPGRSTSTNITKITLAPLCEDDIVSYVAATLSLPKEEVQPLALAVKSKTAGNPFYIREMLSTAHEKKCIWYDYATAQWKFDMDKLFSQFQGEQDYRVLDCAFITRRLSELPSASRCILAWAALLGQTFSFDLICKLMEEGRYLDEDPKSPCEAFKTPASQEEMFAGLDAAIQAFIIVPSDRDDLFRFAHDRYVQAASALRECNARKMHFVIAQVLLQNGLHYLAPKDSAAAHICEAIDIIKAKIPHRQRFRKVLLEHAHEATESGARPTAAKYYNAAVALLQPDPWNDGGDTEDVSYEETLQLYLQAAECQLYMGNQGAASELLQTVFDHGRTPLDKAPAWILKSRIFTHNGDEEQALNSLRQCLKELDIVLDEHPTMERCDEDFERLAAKIQETDRQLILDPQGTEIHVDDYSIDSSFLASLGAVLAEAASAGWWTDCAVFYQVSLYMVDMHFRRGAYPQSGLAFLYMAVIALSRFNRVQLAADLSAICLELLDRFRDPYSLSRGYMIYANFVGHIQDPIELWLGQLDGIVDYAAAASDRISTILSFGLAAHLKFFASENCSDIEAFCQYGCEEIPNWQLDTRGGTLLIAVRQVARALQGKTRFTSPLDVMSDGEHDSTAYKNWLTDRTRYRGRALMWYQTMEMVPLFLYGHYDRAIEVGKACLESEHVLWSARNTKLATFFYGLALAGAALRQQQDPRLRGQEEESVSRAKVEEVVRQIEVLNCKLKAWQIVDKVNYAAWSKLLDAQVSELLGHHGAAIRQYEQALDHAAEHNFTFEEALGNYLMANIFIRNEARRSARSALRDAIALFRQFGATGIADRIESDHSILLHGAVRNSRTVDVGVQTDFSAEAHYRAVIDAASGSIADDHHSQHSSLSDAVTTDERMASWKGTLQSSTAGAASLPALDMIDMHGILLSSQTISSVLHVDELLKTMCDVILKTCSGSATLAAIIVADEEAEAGTTDCWCVAASGDLENGAKAHIPPVPLSDTDLVAENVVLYTTRFREAVFLQDLIADERFSNVGEDWLRKNPSSKAVISIPIHSASQPLIGVLYLEGLPGSFTDRNVSVLQLLVNQIGISYSNALAMKAIEKVSAENVSMVELQKRALAKAIEAEAKAKNAEAEAIRNVKLAEDATKAKSIFLANVSHELRTPLNGVIGNSELLRDSNLNKEQLEMADSIRVSADLLLTVINDILDFSRMEADKMKLYIIAFNPEEMVREVVRAVSYSNREKTRKNNVQIVKDINLPPMLIYGDPIRLHQVLGNLIGNSLKFTEDGTITIGARIDSETEDKATLTFWVKDTGIGISPQQLENLFQPFSQADASTARKYGGSGLGLSICKSLIETMMKGTIHLESEENVGTTAWFTVTFEKARPEVVAGEEKPPSPSDTHSHPALPESPSNTGYHSPSPSISSHPHSPDLGAVPSPTFGAHGPPPDLTCIPKSELRICIAEDNAINAKIAMQYMHRLGYPNVDTYENGLEAVKGLREKSREGKPYHIILMDVQMPLLDGYEATRMLRQDEDENVRKVLVIAMTASAIQGDREKCLAAGMDDYLAKPVRSEVLKRKLDAYVTPEGRRALLGLSQTRPSTLGQGQGQTKVQEVKESKNSNEEDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZU2</accession>
    <name>G0RZU2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Histone deacetylase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0004190</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690962.1">
        <property type="nucleotide sequence ID" value="XM_006690899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZU2"/>
    <dbReference type="STRING" id="759272.G0RZU2"/>
    <dbReference type="GeneID" id="18254457"/>
    <dbReference type="KEGG" id="cthr:CTHT_0004190"/>
    <dbReference type="eggNOG" id="KOG2682">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023643_7_0_1"/>
    <dbReference type="OMA" id="EQCKKCR"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF6">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="8">
        <location>
            <begin position="16"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS23720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="250" mass="27574" checksum="5CC5B6E7C2AE2F78" modified="2011-10-19" version="1">MGQAPSFAIDPDTPPLTLKERSLNAVAEFIKSGRARRIVVMTGAGISTAAGIPDFRSPDTGLYSNLMDLDLPEPEAIFDIEYFRTNPKPFYVLAKELYPGRYHPTISHVFISLLGRKGLLHMLFTQNIDCLERAAGIPPELIVEAHGSFATQRCIVCKAPFDDVKMKEFVSQAKVPHCEEEGCNGLVKPDITFFGEALPRKFYENIDYARTADLVIVMVGNFGSRADDVMLLMDCDKGVRDLANALGVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZX9</accession>
    <name>G0RZX9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative heat shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0008010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2013" name="Nat. Struct. Mol. Biol." volume="20" first="23" last="28">
            <title>Structural characterization of a eukaryotic chaperone--the ribosome-associated complex.</title>
            <authorList>
                <person name="Leidig C."/>
                <person name="Bange G."/>
                <person name="Kopp J."/>
                <person name="Amlacher S."/>
                <person name="Aravind A."/>
                <person name="Wickles S."/>
                <person name="Witte G."/>
                <person name="Hurt E."/>
                <person name="Beckmann R."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="23202586"/>
            <dbReference type="DOI" id="10.1038/nsmb.2447"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 1-403 IN COMPLEX WITH ATP</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2017" name="Nat. Struct. Mol. Biol." volume="24" first="144" last="151">
            <title>Structural insights into a unique Hsp70-Hsp40 interaction in the eukaryotic ribosome-associated complex.</title>
            <authorList>
                <person name="Weyer F.A."/>
                <person name="Gumiero A."/>
                <person name="Gese G.V."/>
                <person name="Lapouge K."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="28067917"/>
            <dbReference type="DOI" id="10.1038/nsmb.3349"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (3.20 ANGSTROMS) IN COMPLEX WITH ATP</scope>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2020" name="Nat. Commun." volume="11" first="1504" last="1504">
            <title>The ribosome-associated complex RAC serves in a relay that directs nascent chains to Ssb.</title>
            <authorList>
                <person name="Zhang Y."/>
                <person name="Valentin Gese G."/>
                <person name="Conz C."/>
                <person name="Lapouge K."/>
                <person name="Kopp J."/>
                <person name="Wolfle T."/>
                <person name="Rospert S."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="32198371"/>
            <dbReference type="DOI" id="10.1038/s41467-020-15313-w"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 2-578 IN COMPLEX WITH ATP</scope>
    </reference>
    <reference evidence="9 10" key="5">
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    <sequence length="357" mass="40345" checksum="E3D6F111FF271365" modified="2011-10-19" version="1">MQSRDDFIKDVLDGVTAATMAIRITPYILSRINWKDPRHDPLVRQFLPLKSAMLPDHPKLALDSLHEEADSPVKGLVHRYPDKALFLHTVTKASLRPTRKRWEEVFTYIEKHPELQDIVVSGGDSYYLQPEHIRLIGERLISMPNIKRFRFASKGLAVAPARILDESDGWVNALIDISNMAKKAGKAMALHTHFNHPNEISWITSAASQRLFEDGVMVRNQTVLLRGVNDDLETMSTLIRTLADNNIFPYYVYQCDMVQRVEHLRTPLQTILDLEAQIRGTIAGFMMPSFVVDLPGGGGKRLACSFQSYDRTTGISRYTAPAVKGRDKENKVYEYYDPIDTLPGASSTKTDECVGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0D6</accession>
    <name>G0S0D6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0009640</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="476" last="476">
            <title>High-resolution structures of a thermophilic eukaryotic 80S ribosome reveal atomistic details of translocation.</title>
            <authorList>
                <person name="Kisonaite M."/>
                <person name="Wild K."/>
                <person name="Lapouge K."/>
                <person name="Ruppert T."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="35079002"/>
            <dbReference type="DOI" id="10.1038/s41467-022-27967-9"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.90 ANGSTROMS)</scope>
    </reference>
    <reference evidence="12 13 14" key="3">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e56910" last="e56910">
            <title>Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation during pre-60S biogenesis.</title>
            <authorList>
                <person name="Lau B."/>
                <person name="Huang Z."/>
                <person name="Kellner N."/>
                <person name="Niu S."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
                <person name="Cheng J."/>
            </authorList>
            <dbReference type="PubMed" id="37129998"/>
            <dbReference type="DOI" id="10.15252/embr.202356910"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <reference evidence="16 17 18" key="4">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e57984" last="e57984">
            <title>Structural insights into coordinating 5S RNP rotation with ITS2 pre-RNA processing during ribosome formation.</title>
            <authorList>
                <person name="Thoms M."/>
                <person name="Lau B."/>
                <person name="Cheng J."/>
                <person name="Fromm L."/>
                <person name="Denk T."/>
                <person name="Kellner N."/>
                <person name="Flemming D."/>
                <person name="Fischer P."/>
                <person name="Falquet L."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="37921038"/>
            <dbReference type="DOI" id="10.15252/embr.202357984"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.12 ANGSTROMS)</scope>
    </reference>
    <reference evidence="10 11" key="5">
        <citation type="journal article" date="2023" name="Nat. Struct. Mol. Biol." volume="30" first="670" last="677">
            <title>Structural inventory of cotranslational protein folding by the eukaryotic RAC complex.</title>
            <authorList>
                <person name="Kisonaite M."/>
                <person name="Wild K."/>
                <person name="Lapouge K."/>
                <person name="Gese G.V."/>
                <person name="Kellner N."/>
                <person name="Hurt E."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="37081320"/>
            <dbReference type="DOI" id="10.1038/s41594-023-00973-1"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.20 ANGSTROMS)</scope>
    </reference>
    <reference evidence="15" key="6">
        <citation type="journal article" date="2024" name="Nat. Commun." volume="15" first="716" last="716">
            <title>Methionine aminopeptidase 2 and its autoproteolysis product have different binding sites on the ribosome.</title>
            <authorList>
                <person name="Klein M.A."/>
                <person name="Wild K."/>
                <person name="Kisonaite M."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="38267453"/>
            <dbReference type="DOI" id="10.1038/s41467-024-44862-7"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.10 ANGSTROMS)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691488.1">
        <property type="nucleotide sequence ID" value="XM_006691425.1"/>
    </dbReference>
    <dbReference type="PDB" id="7OLC">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="LE=1-200"/>
    </dbReference>
    <dbReference type="PDB" id="7OLD">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="LE=1-200"/>
    </dbReference>
    <dbReference type="PDB" id="7Z3N">
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        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="LE=1-200"/>
    </dbReference>
    <dbReference type="PDB" id="7Z3O">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.30 A"/>
        <property type="chains" value="LE=1-200"/>
    </dbReference>
    <dbReference type="PDB" id="8I9P">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="LE=1-200"/>
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    <dbReference type="PDB" id="8I9R">
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        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="LE=1-200"/>
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    <dbReference type="PDB" id="8I9T">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.60 A"/>
        <property type="chains" value="LE=1-200"/>
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        <property type="resolution" value="3.10 A"/>
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        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="LE=1-200"/>
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        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="LE=1-200"/>
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    <dbReference type="PDB" id="8I9Y">
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        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="LE=1-200"/>
    </dbReference>
    <dbReference type="PDB" id="8I9Z">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="LE=1-200"/>
    </dbReference>
    <dbReference type="PDB" id="8IA0">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="LE=1-200"/>
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        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="LE=1-200"/>
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        <property type="resolution" value="2.56 A"/>
        <property type="chains" value="LE=1-200"/>
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        <property type="method" value="EM"/>
        <property type="resolution" value="2.63 A"/>
        <property type="chains" value="LE=1-200"/>
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        <property type="chains" value="LE=1-200"/>
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        <property type="resolution" value="2.90 A"/>
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        <property type="resolution" value="2.86 A"/>
        <property type="chains" value="LE=1-200"/>
    </dbReference>
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        <property type="resolution" value="2.94 A"/>
        <property type="chains" value="LE=1-200"/>
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        <property type="chains" value="LE=1-200"/>
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        <property type="resolution" value="2.91 A"/>
        <property type="chains" value="LE=1-200"/>
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        <property type="method" value="EM"/>
        <property type="resolution" value="2.55 A"/>
        <property type="chains" value="LE=1-200"/>
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    <dbReference type="AlphaFoldDB" id="G0S0D6"/>
    <dbReference type="EMDB" id="EMD-12976"/>
    <dbReference type="EMDB" id="EMD-12977"/>
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    <dbReference type="EMDB" id="EMD-17951"/>
    <dbReference type="EMDB" id="EMD-17952"/>
    <dbReference type="EMDB" id="EMD-17953"/>
    <dbReference type="EMDB" id="EMD-17954"/>
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    <dbReference type="EMDB" id="EMD-17956"/>
    <dbReference type="EMDB" id="EMD-17957"/>
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    <dbReference type="EMDB" id="EMD-35285"/>
    <dbReference type="EMDB" id="EMD-35286"/>
    <dbReference type="EMDB" id="EMD-35287"/>
    <dbReference type="EMDB" id="EMD-35288"/>
    <dbReference type="EMDB" id="EMD-35289"/>
    <dbReference type="EMDB" id="EMD-35290"/>
    <dbReference type="SMR" id="G0S0D6"/>
    <dbReference type="STRING" id="759272.G0S0D6"/>
    <dbReference type="GeneID" id="18255002"/>
    <dbReference type="KEGG" id="cthr:CTHT_0009640"/>
    <dbReference type="eggNOG" id="KOG1694">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066767_2_0_1"/>
    <dbReference type="OMA" id="KWYNADD"/>
    <dbReference type="OrthoDB" id="2436667at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13156">
        <property type="entry name" value="KOW_RPL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000014">
        <property type="entry name" value="60S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000915">
        <property type="entry name" value="60S_ribosomal_eL6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049633">
        <property type="entry name" value="Ribosomal_eL6_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041997">
        <property type="entry name" value="Ribosomal_eL6_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01159">
        <property type="entry name" value="Ribosomal_L6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01170">
        <property type="entry name" value="RIBOSOMAL_L6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8 9 10" id="KW-0002">3D-structure</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS23297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="7OLC"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="7OLD"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="7Z3N"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="7Z3O"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="8I9P"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="8I9R"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="8I9T"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="8OO0"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="8PV1"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PDB" id="8PV2"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PDB" id="8PV3"/>
        </source>
    </evidence>
    <sequence length="200" mass="22092" checksum="D74AFF43507DB484" modified="2011-10-19" version="1">MSAAPTTKTFGKGTRTVPAPSEKAQKWYPAEDEAQPKKVRKAVRPWTPRKSLQPGTVLILLAGRFRGKRVVLLKCLDQGVLLVTGPFKINGVPLRRVNARYVIATSVKVDLTGVDQAKIDEVAQPKYFTAEKAKEKASEEAFFKQGEKPQKKPVSSTRAADQKAIDKALIANIKKVDMLASYLASSFSLRKGDKPHLMKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0L3</accession>
    <name>G0S0L3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">pyruvate, water dikinase</fullName>
            <ecNumber evidence="5">2.7.9.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Pyruvate, water dikinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CTHT_0010420</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>pyruvate + ATP + H2O = phosphoenolpyruvate + AMP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:11364"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.2" evidence="5"/>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691565.1">
        <property type="nucleotide sequence ID" value="XM_006691502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0L3"/>
    <dbReference type="STRING" id="759272.G0S0L3"/>
    <dbReference type="GeneID" id="18255080"/>
    <dbReference type="KEGG" id="cthr:CTHT_0010420"/>
    <dbReference type="eggNOG" id="ENOG502QREJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007308_6_2_1"/>
    <dbReference type="OMA" id="HFFHEVG"/>
    <dbReference type="OrthoDB" id="6123450at2759"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008986">
        <property type="term" value="F:pyruvate, water dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000010">
        <property type="entry name" value="Phosphoenolpyruvate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000017">
        <property type="entry name" value="Phosphoenolpyruvate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.10">
        <property type="entry name" value="Phosphohistidine domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006319">
        <property type="entry name" value="PEP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01418">
        <property type="entry name" value="PEP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005057">
        <property type="entry name" value="PRK06464.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43030">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43030:SF1">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000854">
        <property type="entry name" value="PEP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="Phosphohistidine domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate phosphate dikinase AMP/ATP-binding" evidence="15">
        <location>
            <begin position="24"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilising enzyme mobile" evidence="14">
        <location>
            <begin position="395"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilising enzyme C-terminal" evidence="16">
        <location>
            <begin position="487"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGS22573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="801" mass="87309" checksum="5DA54BA261234D6C" modified="2011-10-19" version="1">MAPDHSTNKPLVRNFEHLTRQDVASVGGKNSSLGEMIGGLASKGVAIPPGFATTSDAFWQFIDTNCLRDKIAQLIEQWSSGQATLAETGQAVRRLIVGGKWPEDAAAAIKTAYRQLSEKAGIKNLSVAVRSSATAEDLPSASFAGQLESYLNVSGEDQLLDACRRCYASLFTDRAISYRQTRGFDHLSIALSVGVQRMVRAGDRHGASGVMFSLDTESGFDQIVLINAAWGLGENIVQGAVDPDEYQVFKPLLNNRPDLVPIVQKKRGEKEIKMIYGDGETIRTRNVPTSRAERAAFVLSDEDILQLARWACTIEKHYGCPMDMEWAKDGTTGELFIVQARPETVHSRNTSAVIKTYDVGKKGRILATGHSIGDAAVTGRVCMIESAKDIDKFVEGSVLVTGSTDPDWVPIMKKAAGIVTDHGGRTSHAAIVSRELGLPAVVGTGNATYVLHTGQDVTVSCAEGDIGYVYEGVSEITTHTVDLAKMPTVQTNVMLNLANPAAAYRWWRLPSDGIGLARMEFVINNAICVHPMALVRYDQLKDEDAKKEIAKLTIGYTTKPDYFVDTLARGLASLCATVYPRPAIIRMSDFKTNEYAGLLGGDEFEPREENPMLGFRGASRYYSPQYKEGFALECRAIKKLREVLGFTNAIVMIPFCRTVAEAKKVLDVMGENGLKRGENGLHVYVMCEIPSNVILAAEFCKYFDGFSIGSNDLTQLTLGVDRDSRELADLFSEQDEAVKWMIARVISVARKEGRKIGICGQAPSDHPEFAKFLVSAGIDSISVSPDSFLPVKQNIVEAEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0M4</accession>
    <name>G0S0M4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">NAD(P)H-hydrate epimerase</fullName>
            <ecNumber evidence="3 10">5.1.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">NAD(P)HX epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0010540</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="10">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.1.99.6" evidence="3 10"/>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691576.1">
        <property type="nucleotide sequence ID" value="XM_006691513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0M4"/>
    <dbReference type="STRING" id="759272.G0S0M4"/>
    <dbReference type="GeneID" id="18255092"/>
    <dbReference type="KEGG" id="cthr:CTHT_0010540"/>
    <dbReference type="eggNOG" id="KOG2585">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024853_3_0_1"/>
    <dbReference type="OMA" id="RHLFHYG"/>
    <dbReference type="OrthoDB" id="10064708at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NAD(P)HX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10260:FF:000005">
        <property type="entry name" value="NAD(P)H-hydrate epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01966">
        <property type="entry name" value="NADHX_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032976">
        <property type="entry name" value="YJEFN_prot_NAXE-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232:SF10">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="11">
        <location>
            <begin position="11"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="61"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="127"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS22584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="238" mass="25722" checksum="57D12AEF1A566AC8" modified="2011-10-19" version="1">MALKTIGAAAAVALDKELMSTGAFSIDQLMELAGLSVSQVVYRVHPPHKGKRILVAVGPGNNGGDGLVAARHLRHYGYQPTIYYPKRGKNELYQRLVKQLEDLEVPFTDDFPAALQSADHVIDAVFGFSFSGEVREPFPAVINAMAEANVPVTSVDAPSSWDIENGPPKSGVGSNFHPDVLVSLTAPKPLVKYFKGRHFIGGRFVTPAIAKKYGFDLPPYEGLDQVVEVDPDGKPVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0Q5</accession>
    <name>G0S0Q5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0010870</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691607.1">
        <property type="nucleotide sequence ID" value="XM_006691544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0Q5"/>
    <dbReference type="STRING" id="759272.G0S0Q5"/>
    <dbReference type="GeneID" id="18255125"/>
    <dbReference type="KEGG" id="cthr:CTHT_0010870"/>
    <dbReference type="eggNOG" id="ENOG502QTAT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008220_0_0_1"/>
    <dbReference type="OMA" id="ADHSIGW"/>
    <dbReference type="OrthoDB" id="38531at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057688">
        <property type="entry name" value="DUF7928"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408:SF3">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25550">
        <property type="entry name" value="DUF7928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="684"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="723"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="765"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="820"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="848"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7928" evidence="4">
        <location>
            <begin position="72"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="3">
        <location>
            <begin position="494"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS22615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="877" mass="98581" checksum="333CBE3FDB0D9FD4" modified="2011-10-19" version="1">MGVGSYFKATGSPATEAAQTPYQTQSPNPTPEPSSRPTSVLQPPTPRYGSRPQSLSGRSTRSNNSSFILDDIKHEVMVNYLYQQQCANLWVSDGSGEIEGVLLRKSRGHYMACPPQLGSSPFAMACAALNVQCAMTVNSRVIKTFLQWSPDAVDVPLTNGLRVQILPTIDDLPRARKHQFAAFIASEGLLVVWDDDALHLVQRAKAIESELMQLVWRAGTEGDEEDEKATGRGEPEIDEESGEIKPEKRPVHLMNTYLVTLTLILVTVSIGAAGRQLAIEVSVDGNYVRLALLALAPVQIFFTLFFCQVIVGCLAQIFGPIRQLTINSKFYSAKPPPRLRSAVLPHVTIQCPVYKEGLQTVIAPTVKSIKQAMSTYELQGGSANLFINDDGLQLISEEERRARIEFYADHSIGWVARPKDGENGFKRRGKFKKASNMNFALMISCKVEDKLAQIERGPEWTQHDEAQAYEKALKEVLEEDGRAWADGNIRIGDYILLIDSDTRVPADCLLDAVSEMELSPDVGIMQFSSGVMQVVHTYFENGITFFTNLIYSAIRYTVSNGDVAPFVGHNAILRWSAIQQVSYVDEDGYEKFWSESHVSEDFDMSLRLQCNGYIIRLAAWAGDGFKEGVSLTVYDELARWEKYAYGCNELLFHPIRTWLWKGPFTPLFRRFLFSNIRFTSKVTVISYIGTYYAIGAAWIMTSVNYFLMGWFNGYLDKYYLDSWQVWFSIILVFNGLGNIALAVMRYRVGERSILYALYENFKWTIMLAIFLGGLSLHISQALLAHMFEIDMQWGATAKEVEFSNFFIEVPKVLRKFKFSMLFSMAFIVGMIILATAPFIPYSWHITDFVAILPMATVAASHLLLPIALNPALMTFSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0W0</accession>
    <name>G0S0W0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0011430</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691662.1">
        <property type="nucleotide sequence ID" value="XM_006691599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0W0"/>
    <dbReference type="GeneID" id="18255181"/>
    <dbReference type="KEGG" id="cthr:CTHT_0011430"/>
    <dbReference type="HOGENOM" id="CLU_711726_0_0_1"/>
    <dbReference type="OrthoDB" id="10651156at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="329"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="388" mass="41548" checksum="905B55EC7D9E1277" modified="2011-10-19" version="1">MLLPPPSVVSPTPSPSTLPPLPPAVTPSPEIGVPLPRLILQSRNPLLQQRQFDGLFTVSFDTYTCPSDSCSDCLRLNYAYQCTSFITSCLPDMMTKADYYGAFSSCLCNYGDGYLDCFYDRVATGSCISLYSVDYYRTLELSMYMSLCGSAPNGLTTKVPTRSFQPTANSGGTPNQNYGAGNNANIEDTDKNDKGGLSAAAKVGIGVGVGIGALLIAGLIFAVWWYRRKAKASKAVTAADTTSGKPNGSQAMQQQPVVGETKNPELAGYYVPQQPPSSTPSPYPYNATSTPVSQTSTAQPVSPGATVALYSSVSPPPQSVVEADSREIASQPQNQHQYQPYQQPYSPPAHAQLNTQYYQQAGQSPQPPQQAQQPVYPQHPNIPELSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0S111</accession>
    <name>G0S111_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0011950</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691713.1">
        <property type="nucleotide sequence ID" value="XM_006691650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S111"/>
    <dbReference type="STRING" id="759272.G0S111"/>
    <dbReference type="GeneID" id="18255233"/>
    <dbReference type="KEGG" id="cthr:CTHT_0011950"/>
    <dbReference type="eggNOG" id="ENOG502QUGB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_411045_0_0_1"/>
    <dbReference type="OrthoDB" id="410044at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000736">
        <property type="entry name" value="Polyadenylate-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="RNA-binding domain, RBD"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="189"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="371"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="17"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="72"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="584"/>
            <end position="609"/>
        </location>
    </feature>
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        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="584"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="598"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS22721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="609" mass="66505" checksum="B9C92C6D0850FFCD" modified="2011-10-19" version="1">MSGMIRAFKNGDASFNNRRVRSLSGGSSNGSSSASEEGGARLSQASNSPAQNRVRFSSITQEFGRFTLSCTASSGGSVKETTESSSPFQVGKPSDVFMGSPTKPARKVDADEAHDPFIKAQAALVMMGASRDHHLVKAVATDNGNTAVSSGMDGNGPIRNTPSRNTPNRSASRHQIGGVDVQGIYPPSACVFVANLPESKDDRTLEVGIVREFSKYGTVFVKIRRDANRMPFAFCQYTKDEDAQLAMREGKGALICGRPCRTEMVKANRTFLVYSRKGNSITTEEARAIMEPYGELSECKMLSAQIQEALKLPGCAILVEFANFDPKRDLNMAVRENDEYCIDAFDLKKKNIVSRADADEEFLRKYDVDRRSIFIGRLPFDVDKEEIIELFSAVGEILNVDLIKRKQDGIISTVFAFVEFARADTPDIAIAKFNGKMMRGFPINVERKVFKHAGTPRRVKSQAFTKVSVTPKTPKSATLPKSPLAEISDNTNFNTPLPASQTRAFEEPVVATTTPLVYHAASPIALGADGKSLIGLGGIPASTPAMAVPLNPYSFVGGYWPNITTFQDPITGVTYYTQTPSVVQQEAATPQQVPDTPTRSREHRERRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>G0S121</accession>
    <name>G0S121_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0012050</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006691660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S121"/>
    <dbReference type="GeneID" id="18255243"/>
    <dbReference type="KEGG" id="cthr:CTHT_0012050"/>
    <dbReference type="HOGENOM" id="CLU_1815580_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="142" mass="14652" checksum="5BA8F4EA2180A6C6" modified="2011-10-19" version="1">MSPSSLTTSPETTPTPTPSLSPSPVTSPETPGTTPATTPSTTIITTTSVEPVTTTTEFLPPPAQETETTTSADISHYSASSHHHRTNTATSFWPGVSTDQPGAPAPTSAPQPQNPFNDGGRPLDHHHNFTELAGGVGEGRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0S149</accession>
    <name>G0S149_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0012340</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006691688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S149"/>
    <dbReference type="STRING" id="759272.G0S149"/>
    <dbReference type="GeneID" id="18255272"/>
    <dbReference type="KEGG" id="cthr:CTHT_0012340"/>
    <dbReference type="eggNOG" id="KOG1204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_11_1"/>
    <dbReference type="OMA" id="GAYTAWA"/>
    <dbReference type="OrthoDB" id="153074at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF8">
        <property type="entry name" value="BENZIL REDUCTASE ((S)-BENZOIN FORMING) IRC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS22759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="196" mass="21288" checksum="95783EA49D7ECA71" modified="2011-10-19" version="1">MEPKVIIVTGASRGIGLAVARVLLQASHKVVLIARSAEQLQALKEQYPEQVAYLAADMTVSDVKETIPHLRKTKGRIIFTSSGAATGAYTAWAAYGSSKAALNSLAKHVAVEEPDIISVAISPGRVDTDMQKEIREKGTAMAPKEYETFKADFEQGRLVRPEQSGGVIARLAVDAKADLSGKYFKWDAPELVEYRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1A1</accession>
    <name>G0S1A1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MADS-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0012860</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691803.1">
        <property type="nucleotide sequence ID" value="XM_006691740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1A1"/>
    <dbReference type="STRING" id="759272.G0S1A1"/>
    <dbReference type="GeneID" id="18255324"/>
    <dbReference type="KEGG" id="cthr:CTHT_0012860"/>
    <dbReference type="eggNOG" id="KOG0015">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063931_1_0_1"/>
    <dbReference type="OMA" id="GGHYPQD"/>
    <dbReference type="OrthoDB" id="2284405at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00266">
        <property type="entry name" value="MADS_SRF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000002">
        <property type="entry name" value="Serum response factor b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050142">
        <property type="entry name" value="MADS-box/MEF2_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033897">
        <property type="entry name" value="SRF-like_MADS-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48019">
        <property type="entry name" value="SERUM RESPONSE FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00350">
        <property type="entry name" value="MADS_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="54"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="135"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="192"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS22811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="221" mass="24323" checksum="8874A52022459846" modified="2011-10-19" version="1">MADITDQHDQTAPNELDQSHTVSNGTAPANENRGVKRQRTNDDDDDDEGEKGGRERRKIEIKFIADKSRRHITFSKRKAGIMKKAYELSVLTGTQVLLLVVSETGLVYTFTTPKLQPLVTKAEGKNLIQACLNAPEPPAGDNGVDDTNPVEAPEEPANAAHLPPQPNRPPMPPNHMPPSYMPNVGMDPQQALAYSNYVQQQQRGSQYMPPSSLQQHAGHQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1C1</accession>
    <name>G0S1C1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SURF1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0013070</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Probably involved in the biogenesis of the COX complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SURF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691823.1">
        <property type="nucleotide sequence ID" value="XM_006691760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1C1"/>
    <dbReference type="STRING" id="759272.G0S1C1"/>
    <dbReference type="GeneID" id="18255345"/>
    <dbReference type="KEGG" id="cthr:CTHT_0013070"/>
    <dbReference type="eggNOG" id="KOG1563">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047737_3_0_1"/>
    <dbReference type="OMA" id="WYSRDVA"/>
    <dbReference type="OrthoDB" id="10040024at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06662">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002994">
        <property type="entry name" value="Surf1/Shy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427:SF2">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02104">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50895">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS22831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="341" mass="39276" checksum="63D99CCA47AF5E4B" modified="2011-10-19" version="1">MVSGRLLSGLLQPFCAPRAPIGNAIRSQWTHSTPVLRSNFSSSRSIISQINVSRRQPFHSTPRRPRDPADDPNWKSLIDEPPQLVRVKSKHGPGIILLAIIPITAFLLGTWQVHRLRWKTDLIAKAEDRIIRPPLPLPPHVDPDAVADFDFRRVTVTGRFRHDKEMLVGPRMRDGEQGYMVVTPLERNDDPTATVLVHRGWISKKMADQRLRDPEALPQGEVTIEGMLRTPWKKNFFTPENRPDRWEFYFPDVKQMAELTGSQAVWIEQTMDPDFFTLNAYQEKGVPIGRPAEVNLRNNHAQYIITWYGLSLATAIMFWMVLKSKKSPNEAARRVRMNMHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>G0S226</accession>
    <name>G0S226_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Glutamate decarboxylase</fullName>
            <ecNumber evidence="3 9">4.1.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0015750</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-glutamate + H(+) = 4-aminobutanoate + CO2</text>
            <dbReference type="Rhea" id="RHEA:17785"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="4.1.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.15" evidence="3 9"/>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS23086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692078.1">
        <property type="nucleotide sequence ID" value="XM_006692015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S226"/>
    <dbReference type="STRING" id="759272.G0S226"/>
    <dbReference type="GeneID" id="18255613"/>
    <dbReference type="KEGG" id="cthr:CTHT_0015750"/>
    <dbReference type="eggNOG" id="KOG1383">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019582_2_2_1"/>
    <dbReference type="OMA" id="ECRDKNM"/>
    <dbReference type="OrthoDB" id="5152799at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004351">
        <property type="term" value="F:glutamate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000017">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.160:FF:000004">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.50:FF:000001">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010107">
        <property type="entry name" value="Glutamate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01788">
        <property type="entry name" value="Glu-decarb-GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321:SF6">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="483"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="483"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS23086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="579" mass="65602" checksum="5128CFDC87CE89E4" modified="2011-10-19" version="1">MVHLASVPGPDTRQLAERPKKVQLQLSNDEDDFTTSVYGSRYAAQDLPRHEMPEREMPKEVAYRMIKDELSLDGNPMLNLASFVTTYMEEEAEKLMTEAFPKNFIDYEEYPQSAEIQNRCVSMIARLFHAPEGNSEHAGAIGTSCVGSSEAIMLAVLAMKKRWKNRRLAEGKPCDRPNLVMSSAVQVCWEKACRYFEIEEKLVYCTPERYVIDPEETVKLVDENTIGICCILGTTYTGEYEDVKGVNDLLMKKGLNVPIHVDAASGGFVAPFVVPDLEWDFRLEHVVSINVSGHKYGLVYPGIGWVVWRSAEYLPQELVFNINYLGADQASFTLNFSKGASQVIGQYYQFIRLGKHGYRAIMSNLTRIADYLSDSLEALGFIIMSKKSGEGLPLVAFRLPPKEDRHYDEFSLAHQLRVRGWVVPAYTMAPHTGNMKMLRVVVREDFTKNRCDNLINDIRSSQALLEQMDRESIKRQEEFIHKHHTASGKATHNHPKFRGYRERNTRSKARQARLTLSAKTAAHHERSFSIEQKRDIKTGQVVSSKTTAVQTANVGQQATLSLELPGGRQLMTFRISCPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G0S281</accession>
    <name>G0S281_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0016300</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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    <dbReference type="eggNOG" id="ENOG502RSQP">
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    <dbReference type="OMA" id="NITAGQW"/>
    <dbReference type="OrthoDB" id="5354458at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="DUF7785"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057199">
        <property type="entry name" value="DUF7877"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="70"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7785" evidence="2">
        <location>
            <begin position="458"/>
            <end position="558"/>
        </location>
    </feature>
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            <begin position="1"/>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        </location>
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            <end position="114"/>
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    </feature>
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            <end position="281"/>
        </location>
    </feature>
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        <location>
            <begin position="695"/>
            <end position="705"/>
        </location>
    </feature>
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        <location>
            <begin position="721"/>
            <end position="744"/>
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    </feature>
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    </feature>
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            <end position="946"/>
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    </feature>
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    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS22114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="984" mass="106241" checksum="3ACF4E0D704EE40F" modified="2011-10-19" version="1">MASPDVAPPQANGVAALSRPDSPASSIASQSTKRKREPADEAAVDPSLSAISDSQKPTLNGQRAASECMPLIRDFFAVLESFDSSESPILKRHLPEPVSHGEPSTKRAKSEDPSKPLTIADKVTQNAYENLDDFVVDVARATDARIKDLEAAGATADENAIAEAAAFKTKALELYRRELAYPNVPPPSSSGKVSSISTRTGGVVLSTVGMAPTMRPLFTSLRQAPDGSNKPLPETALPNGVSVTRVLQEPPLTGDKSGRTPTLGELFPSPRNLPPLQPPKAPKTTTKSNVLTFYHPEFIDKSKYRTGTYFSQVLSQGVWLDYTNATPTVHTKTKQRERAQSLAGVKPSSIELEMTELEALFRGAFSSFAPSRDDSGAIVPAQQVSRIWYQRIGRRNLNKMVEEIEPEVAEEDGVPARADSAVIMEVDEERVKEVIENWDDSLIDPNLDSVLGKKSDEEKQVDDILEEISDMIETLASYQRNRNLTLPTSQDRYSADPVNGDMLRNGSASHQPSEEEMMAYQALKSQLALIIQTLPPWAVARLNSDKLAELAVSTKIEVRSDDYRGVMEEDEPARQARLAAQVATTNQRQSQRAPSVAAAQYANHQYQPQFTPSARPVPNAPHYQPQTPVRPQPNVYSRAPSAVPIPQPHHQARPQPPPAQYRPQMYAPQLAKAQGPYGHSGMPQQYVPSPAQQPRMPPQQPPPPHYNNMVPAGAPPNSRFPQAYPAGYPQQQPIHPQHMPPHAQSVPMPPQHHPPMTQQPMPAPYSPYPNGAPMPRTMSPQVPPQPPHTYAQSPTPQHQQMPRPPPPYGPGTTQPGMPPNTIPRPPPQQYVPGSPGPAGMMPARPPQHQPVAPTPPPGQHPLPAAAMPSYAPVMTTTADNLQPRPATPGHQAPPPGGVVGLAGIGLAGQMDVHKLAAAKMQMAQAQQRTQTPVPVPQVPGQVPPPQLVNGTGVRTVAPSPSPVPGTPTVAPAPVPVPPQQQPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2A0</accession>
    <name>G0S2A0_CHATD</name>
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        <submittedName>
            <fullName evidence="5">26S proteasome regulatory subunit-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0016490</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S3 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EGS22133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006692089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2A0"/>
    <dbReference type="STRING" id="759272.G0S2A0"/>
    <dbReference type="GeneID" id="18255687"/>
    <dbReference type="KEGG" id="cthr:CTHT_0016490"/>
    <dbReference type="eggNOG" id="KOG2581">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019858_1_1_1"/>
    <dbReference type="OMA" id="AKVYFYF"/>
    <dbReference type="OrthoDB" id="1713558at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="CSN3"/>
    </dbReference>
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        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013586">
        <property type="entry name" value="PSMD3_C"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rpn3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25573">
        <property type="entry name" value="TPR_PSMD3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="320"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
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        <location>
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            <end position="57"/>
        </location>
    </feature>
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            <end position="558"/>
        </location>
    </feature>
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            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS22133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="574" mass="64018" checksum="057C85A81167C937" modified="2011-10-19" version="1">MPGKTPDKEPVENRGYRTDKDAKAKGKKTAKKEGEDEMTVVVPPSKTPKQNSVTPPANDTEGDVAMGDIDEAAQEGKVDPVAQTINDIKNNFALLDRAVAHFDARFSLRALRSISSIRKRLTPDVLGQVIAETYNPTSSRAVVAKQMLAAIGRPDVVLGRQAGSDMDIDSEAKPSSKNGLVKKDPLPEVDVFLGILTQVLLHDTKQWQSGYEFSQSLAERVRALNRRTLDSLAAKVYFYFELFAEQIPPLPPSPQSPILLVRPPLLRALRTAVLRKDIDTQASVIVLLLRNYLLTSHISQADLLVSHTQFPENAANNQVARFLYYLGCVRAIQLRYTEAHEHLTAATRKAPSSACALGFSLSATKLLVVVELLMGDIPDRAIFRQPAMEAALRPYLLLVQAVRVGDVDNFEAINNKHEATFKRDGTYTLILRLRQNVIKTGIRMMSLSYSRISLRDICVRLHLKSEESAEYIVAKAIRDGVIEATIDREHGYMKSKEVGDVYATREPAEAFHDRIRACLALHDESVKAMRFPMNPHRLELKNAQEAREREREMAKEIQEGDLDEDDLGGDFDGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2V4</accession>
    <name>G0S2V4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0018610</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006692293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2V4"/>
    <dbReference type="STRING" id="759272.G0S2V4"/>
    <dbReference type="GeneID" id="18255899"/>
    <dbReference type="KEGG" id="cthr:CTHT_0018610"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063727_1_0_1"/>
    <dbReference type="OMA" id="KRNIWSW"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24121">
        <property type="entry name" value="NO MECHANORECEPTOR POTENTIAL C, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24121:SF23">
        <property type="entry name" value="NO MECHANORECEPTOR POTENTIAL C, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="164"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="218"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="253" mass="27462" checksum="102A508C6695866B" modified="2011-10-19" version="1">MTKPTIPEIGKLSYLKEIDPSLRLRRAIHLNDAPLVRRILRTHPDLLHNPDHSLTGNANTNLHLAASLGHLSIVQLLISLGHESPTPALNDDHQTALMLASAAGHTEVVHFLAQHDPSCILRQDMRGRDAIMHASSSGHDTVVQILLTYVPGGAEAALARTDIEGNTALHYASGNGHLLVLRTLLAAGADPYRRNVWNWRARDYCATVRTEVYYDSLVPKEGENGNGAPSRSGSPEARKKGFGARLVGLEVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2V5</accession>
    <name>G0S2V5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative siderochrome-iron transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0018620</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692357.1">
        <property type="nucleotide sequence ID" value="XM_006692294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2V5"/>
    <dbReference type="GeneID" id="18255900"/>
    <dbReference type="KEGG" id="cthr:CTHT_0018620"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012970_1_0_1"/>
    <dbReference type="OMA" id="AATSHQY"/>
    <dbReference type="OrthoDB" id="4078873at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000335">
        <property type="entry name" value="Siderochrome iron transporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000284">
        <property type="entry name" value="Siderophore iron transporter mirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="482"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="563"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="77"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS22338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="598" mass="65593" checksum="BAABF1B7CE16DFEC" modified="2011-10-19" version="1">MKEPISWSQQDIELSPSQNSLDKPAISEKSTTANHAPQTSPPSDTPDRDEISRDAQAGVQDVEALAKVWTRNHLILAYITIWCIHFTDALHQGMSSILTPYVTSSFQLHSLTAATSIFASLVGGLFKLPLAKILDIWGRPQGFVSMLACLTIGLAMMAGCRGVDMYAAGQVFYWVGYNGISYTISVFIADTSALKNRALMFAFASSPYIITVWIGGPLANAFLRGPGWRWGFGVFAVVTPVICSPLLGLFYINYRKARKRGLIPARRGGGSARSWREKLKYYAIEFDVLGLLLITAGLAFFLLPFNLYTRQPSGWKSPLILSLLIIGFLLIPLFALYERFFAPKTFIPYSLLTDRTVLGACVLSGVLFVSFYIWDSYFSSFLQVVNGLDVTHASYVMNIYSIGSCFWSLVVGVAVRWSGRFKWLALYFGVPVTILGVGLMAAFRQPDVNIGYVVMCQIFIAVAGGTLVICEQMAVMAVTTHQYIAVVLAVEAMFASVGGAIGSTVAGAIWSGIFPTKLEKYLPSESRASLAEIVGSLPKQLSYEIGSPTRKAIQWAYGDAQRIMIIASTAVQVISFVSVLVWRDVKVKDFKQVKGLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2X7</accession>
    <name>G0S2X7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0018860</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692379.1">
        <property type="nucleotide sequence ID" value="XM_006692316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2X7"/>
    <dbReference type="STRING" id="759272.G0S2X7"/>
    <dbReference type="GeneID" id="18255924"/>
    <dbReference type="KEGG" id="cthr:CTHT_0018860"/>
    <dbReference type="HOGENOM" id="CLU_1786632_0_0_1"/>
    <dbReference type="OrthoDB" id="4790198at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS22360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="145" mass="16161" checksum="01B7102AE727B17E" modified="2011-10-19" version="1">MHCVKCVGTVVPTALTVSTLATKPEIDTIPESILDTTALGVDVNGPIPSDAVWVELGDGIGYWSARPESFEKWEYANIRIDMWAQDNSHITRASMFSARISCRCLRKGERLEFKRLKGNDWCGTYASKMKVTANRKQHPTFPPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0S343</accession>
    <name>G0S343_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0019590</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692445.1">
        <property type="nucleotide sequence ID" value="XM_006692382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S343"/>
    <dbReference type="STRING" id="759272.G0S343"/>
    <dbReference type="GeneID" id="18255997"/>
    <dbReference type="KEGG" id="cthr:CTHT_0019590"/>
    <dbReference type="eggNOG" id="KOG0872">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047036_3_1_1"/>
    <dbReference type="OMA" id="FVFICPM"/>
    <dbReference type="OrthoDB" id="6354873at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="155"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS22426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="323" mass="37617" checksum="8D81AB73A187BF41" modified="2011-10-19" version="1">MDVALEILDPLVFDKAYAYFVPAKPVPISGNATFAAGAGAAAAQQQSPLSFGSAWPRDNILRQCISLFIITQIGATALYFVFSALSYYFVFDRRLEYHPKFLKNQVRQEIVSSMWAVPFINILTLPFFLAEVRGKSLLYTHIDEYGWPWLIISSILFMIWNDIMIYWIHRLEHHPAVYKYIHKPHHKWIIPTPFAALAFHPLDGYAQSLPYHVFVFICPLQKYLYIFLFIAVQVWTILIHDGDMISGHWLEKYINSPAHHTLHHIYFTVNYGQYFTWCDSYWKSHRPPQPELDPLIDALKVMRQKGLVDEKGNPIPQDKKKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0S398</accession>
    <name>G0S398_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0020220</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692500.1">
        <property type="nucleotide sequence ID" value="XM_006692437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S398"/>
    <dbReference type="STRING" id="759272.G0S398"/>
    <dbReference type="GeneID" id="18256060"/>
    <dbReference type="KEGG" id="cthr:CTHT_0020220"/>
    <dbReference type="eggNOG" id="ENOG502SMB5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014183_2_1_1"/>
    <dbReference type="OMA" id="QGHEGDW"/>
    <dbReference type="OrthoDB" id="2119228at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051532">
        <property type="entry name" value="Ester_Hydrolysis_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383:SF5">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383">
        <property type="entry name" value="THIOESTERASE 1/PROTEASE 1/LYSOPHOSPHOLIPASE L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="251"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="342"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="567" mass="63426" checksum="C0B493686203BC58" modified="2011-10-19" version="1">MSQPTPITGHNDRNRIMVIGDSISHGREGDYTWRYRLWQWFGEQNINVGFFGPFEGTEPPLKPEPPRPPRFPGEEEEIRWPRVDGGQAKQVRASVRDEVKRWRPNLCVIELGFNDLALGGDKPEKVVGNIKGIVEEVQQAVRENFEKEVRILVADVPRRKPYPGMGNLAERIENVDWILRKQIEGGSWGGEVRLVRLSEQYDCCNAAYDGLHPNALGEFQIARAVSRVLVEEFAIGQSPLTIPVELPSRPVPTPTNVTAVPEPSGIAVTWDAVYGAFGYDLRMRAVGTEEWEYHHTRSNRLDATLCTRGQAWEFQVRTSGGDSVKGPWSDSVSAVPDTETVPPPRNIVTHATETGLIATWDPPDLGESAGHLDRYAVIVGHEYCRNVVFVYGVRGEKVEVNSLFPGHRFYVKVKTWTSVGGGCPAEGYPVTVGRGIPPTPGDISLEAMGNTAIEISWTGHPDAAWYSIWVREQRSGWETRLQHNPGPGARPQWPYPAQSADREKFVFYTGDKMPWNLEFSVAAYNGRDGSAWSEWVSLSDHPPDVSIENTDSIVIRLLYKALDDHTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3E9</accession>
    <name>G0S3E9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0020770</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692551.1">
        <property type="nucleotide sequence ID" value="XM_006692488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3E9"/>
    <dbReference type="STRING" id="759272.G0S3E9"/>
    <dbReference type="GeneID" id="18256115"/>
    <dbReference type="KEGG" id="cthr:CTHT_0020770"/>
    <dbReference type="eggNOG" id="ENOG502RASH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037039_1_1_1"/>
    <dbReference type="OMA" id="TGVEMEF"/>
    <dbReference type="OrthoDB" id="5236816at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="535" mass="59733" checksum="6E9A0DF6EB2F26FC" modified="2011-10-19" version="1">MVNMPTATARDNPGTVPDQQQHDFCDAAQTMTLSQSDQSQINPMPVRKRPCIRRVTRPELGSLYDIMHEHAGVALYVLPICWTDLHAKLLDVRFEEMPVINRPIPDLPPGMWVEPSRLAQNLTNELHTLVREEGTPQRIFCKNRAIKHIMSTFFPETMSRPKSDAQLNLYFGKRVFRKVVRVPCVWKSVKSSDASFDSCLTVPATSFSQGLKGSRDTATDYSPNAPIMAYFNKSQLASIRRNLYTVIRGPNNTPNEPVTRLQQLRSKMLTPSNPDYDPYLVAVFLAMAQAHFYREPPSRASSPPESQSQSQRKSIRLTTPKFRDIKLRIITHDEGNDSTPNFVIYTAVVTTSFMERFLHPHKAPPAHESGPGMTITCTPVTVWPILGLKERLAKALGTEIAGEPMFADPEYIALWDALLDQPRTPKQEYSTPSPPPTAPGYRVKRRKRSATPEVSQQSQELDRSGSSFDEEASTRANSPVESREEKKNSGNSISSLGSPSGSASATGSASDDRPVLSPAAKRRRTTRRVSTLEVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3H8</accession>
    <name>G0S3H8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative chaperone protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0021090</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Histones H3 and H4 chaperone involved in the nucleosome formation and heterochromatin silencing. Required for the deposition of H3K56ac-carrying H3-H4 complex onto newly-replicated DNA. Plays a role in the transcriptional regulation of the cell-cycle dependent histone genes by creating a repressive structure at the core histone gene promoter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with histones H3 and H4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RTT106 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692580.1">
        <property type="nucleotide sequence ID" value="XM_006692517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3H8"/>
    <dbReference type="STRING" id="759272.G0S3H8"/>
    <dbReference type="GeneID" id="18256147"/>
    <dbReference type="KEGG" id="cthr:CTHT_0021090"/>
    <dbReference type="eggNOG" id="ENOG502R9PE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033828_0_0_1"/>
    <dbReference type="OMA" id="AMPEAHR"/>
    <dbReference type="OrthoDB" id="75754at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050454">
        <property type="entry name" value="RTT106/SSRP1_HistChap/FACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849:SF3">
        <property type="entry name" value="HISTONE CHAPERONE RTT106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="5">
        <location>
            <begin position="272"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="55"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="367"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="391"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="405"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="419"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00037550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS22561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="461" mass="50612" checksum="391FB0FE3A091565" modified="2011-10-19" version="1">MSSGLDLEKLKWVFRSRPDILTAIQQAADTPARTALFNEIADFVHQRLALADVQNEPAAKRRRVDADQPPSQPHANGHPVTGSWSAVSRGASSAGSSADVTVSEPVLLEIKDISVVVPQRKKYDICFTQSCLFAKAQGATGPAPGLVYPWIEIEHAFFLPVPDKSQTQYNYILLPRDSYLPTSKASGVSSDRQASLEPLVFTVPAAAPKAGSIKGTAAKTAEAFAESYSCLFHWALTTSLRAAGNESFQLISSDPRVFHSLVKQPHRPNEKAVHVKAFRGSKEGFLFFLPTGILWGFKKPLVFLPLDKIAAVSYTNVLRTTFNLVIELDSDVTAGGNATDKEIEFGMIDQEDYQVINENYVQRHGLADRSMAEQRRAKRQLAENLRKSTKAESSGEPSQNDGLTELERAAREAEQRLQDEEDELEEDYDPGSDGDSDGEGSSEDDEGTYDEEGCNEEELGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3U1</accession>
    <name>G0S3U1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Histidinol-phosphatase</fullName>
            <shortName evidence="8">HolPase</shortName>
            <ecNumber evidence="3 8">3.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0038850</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-histidinol phosphate + H2O = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the PHP hydrolase family. HisK subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="3 8"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS22003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694299.1">
        <property type="nucleotide sequence ID" value="XM_006694236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3U1"/>
    <dbReference type="STRING" id="759272.G0S3U1"/>
    <dbReference type="GeneID" id="18257923"/>
    <dbReference type="KEGG" id="cthr:CTHT_0038850"/>
    <dbReference type="eggNOG" id="ENOG502RXUQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054611_0_1_1"/>
    <dbReference type="OMA" id="DYDRPMY"/>
    <dbReference type="OrthoDB" id="5957391at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12110">
        <property type="entry name" value="PHP_HisPPase_Hisj_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000059">
        <property type="entry name" value="Histidinol-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010140">
        <property type="entry name" value="Histidinol_P_phosphatase_HisJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01856">
        <property type="entry name" value="hisJ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039">
        <property type="entry name" value="HISTIDINOL PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039:SF0">
        <property type="entry name" value="HISTIDINOL-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHP" evidence="9">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS22003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="316" mass="35661" checksum="7F9B1126B73353BF" modified="2011-10-19" version="1">MHSHSGQFCPGHAKDTLESIIQHAISIGYKTIGLTEHMPRTSVSDLYPEEFAEAPTPEAVLALQPPRHEAYLAEAIRLREKYSSQITILIGFEGEWIRPEDYSPLIQSLSGRADYFIGSLHHTLTIPIDYDRTMYLQAVCAAAKHRGLPVPSEGESSDEAEEALFEIYFDEQFSLLSTMRPKVIGHFDLIRLFSSSPGRNLTSWPGVWRRIERNLALIKSYDGWLECNTSALRKGLEEPYPKREIAEAWTRMGGKWTFSDDSHGIGQVATNYLRGLKYLQAIGVGEVWTFGRGEDGKLVERGVEIEEFRGSLRLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0S467</accession>
    <name>G0S467_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0030900</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693537.1">
        <property type="nucleotide sequence ID" value="XM_006693474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S467"/>
    <dbReference type="GeneID" id="18257128"/>
    <dbReference type="KEGG" id="cthr:CTHT_0030900"/>
    <dbReference type="eggNOG" id="ENOG502SD1T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2704598_0_0_1"/>
    <dbReference type="OrthoDB" id="9999611at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="73" mass="7781" checksum="D9696B205123ACCA" modified="2011-10-19" version="1">MGSQSWRTSGEQDMAHARATLQAAVEHRDPVKSGYGRAEEIVGKLTGCGGMKHEGAASRAAGQKKDQNKPRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0S490</accession>
    <name>G0S490_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0031130</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693560.1">
        <property type="nucleotide sequence ID" value="XM_006693497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S490"/>
    <dbReference type="STRING" id="759272.G0S490"/>
    <dbReference type="GeneID" id="18257151"/>
    <dbReference type="KEGG" id="cthr:CTHT_0031130"/>
    <dbReference type="eggNOG" id="ENOG502QT0Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_367596_0_0_1"/>
    <dbReference type="OMA" id="FIWANRI"/>
    <dbReference type="OrthoDB" id="4078573at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF40">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="93"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS21264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="758" mass="82891" checksum="2F2AB831B03A40EC" modified="2011-10-19" version="1">MAGSSQRSQTHARHQSHSFHPYPPPTNSYSKEEPSPPYTTSSRTYSPPFDSFSASRQGTPGTFNFGAAHVQLQLEDLDYAMVPSPMVNVNAMVNSNGGREGQQLPPAKAEPGKAKRGGLGRYPKLETPQVPDVDETSTEKTASPDHQMSDSSFSEHVSSSSAPQDNNPTYPNHVGQPPPPQSLICESVREEGMQSFTYYAREPLPPLQQPSPPNFDDDIFMFSPLESHHMNKDKMVISTNKHEYTSGCALSLSSTRTVSSPSAHSIRFEIYNSPAQMPGRPADPPTPASDDATDERDYLDSDDEIRYMQAFVDGVAPWLDSLDGNKHFANTVPYLALKSPMVLNALLACGARQMSLMGGCDEDKAERYYSLALEHLTRIRREQRSDLSECAVAAVVLNAYELMSDKSTDPLHQALPPASALIRECGWDASSGGMEAACFWASVGIEVLASLSSGSHITWDPDQWGVDLEFADGGLESGSSSASVIGFEECVRRPSIGGDGGRGRKGLAAFLMKNGKGFGEESLWVKRIFYILAKVANFRASMPRGLHPDPHEELISRQTRFAECRRLQRICNAWSNSCPRSMRPYGYSAQSSDKSLFPNVWLIKPSAILGRLFYHTSMCLLSQTNPLDQRRSGGSLTSEENRRVQQHHAHHVCGIVAHHLTSVDRRSFVAAAACSLAVVGGVLTDAEERREVLELLGTIGKETGWRMGRLEGELKRAWAAPRVVASGSSSKSDFGGMMSMPLTGLLVGSDFRIGRAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4F2</accession>
    <name>G0S4F2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0022600</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692726.1">
        <property type="nucleotide sequence ID" value="XM_006692663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4F2"/>
    <dbReference type="STRING" id="759272.G0S4F2"/>
    <dbReference type="GeneID" id="18256298"/>
    <dbReference type="KEGG" id="cthr:CTHT_0022600"/>
    <dbReference type="eggNOG" id="ENOG502RS7K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_512865_0_0_1"/>
    <dbReference type="OrthoDB" id="5148182at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="486" mass="52516" checksum="77FD852A6759BB4D" modified="2011-10-19" version="1">MAPVFSCPVDLRAQIKDNCLFLQNHLDADFLIIVAREAPKQYKASVVKTEGRTRTKLFSASGASQDDALQALFDETCEAVNDHIKTNGYGVARDARKHKSKKSHKVYNDDSDSDITSSATTVDGYETFSDEETVSVTSVANTEGHGRRSKHRGRSTKKSTTRKSRRPRSRSPSSSSSSSDFETDVSSISRPRVSVVPPFRAITQRPTAHTPYATRSPLGSQPAPQIGVAVPPPLSPGSQQPHTQPLGPHPQRIMPQSAHMRFHDVCLVIKHHNGSTETERRTISQVAELSQKAIEQGALAYLWRQSLPAQPGNSNNAAHPTTGTATKDVNNADNMPPPHRRIQPSVIVKVKSVSIDGNPYDLSTYRTNDLTKIVEMLRAEAKDNSAIPRFEVDIWNKPYQINTPAPPGQRMPWGYGAVHPPAVGVPPSSLVPPPPPPPPPPQAPVLASPSSVPPPVPRGFPVISAQASTNGVVPEGSALGPDTKMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4F5</accession>
    <name>G0S4F5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Large ribosomal subunit protein mL60</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0022630</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692729.1">
        <property type="nucleotide sequence ID" value="XM_006692666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4F5"/>
    <dbReference type="STRING" id="759272.G0S4F5"/>
    <dbReference type="GeneID" id="18256301"/>
    <dbReference type="KEGG" id="cthr:CTHT_0022630"/>
    <dbReference type="eggNOG" id="ENOG502S81F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141719_0_0_1"/>
    <dbReference type="OMA" id="KYTVFDR"/>
    <dbReference type="OrthoDB" id="2332379at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016340">
        <property type="entry name" value="Ribosomal_mL60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28271">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L31, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28271:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09784">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002216">
        <property type="entry name" value="MRPL31_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR002216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="110" mass="12856" checksum="1582B9E3E235D311" modified="2011-10-19" version="1">MFGPFRITSALSGGLLWKIPWRLSPTQKARQRRRLRAVDTVVEVLSNSLAKTGQKCTAVERWKAEMPTEAEMLPRDKYTMFDRKAKRYRKGIHKLPKWTRVSQRLNPPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4Z3</accession>
    <name>G0S4Z3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Malate dehydrogenase</fullName>
            <ecNumber evidence="3 12">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0032190</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3 12"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693660.1">
        <property type="nucleotide sequence ID" value="XM_006693597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4Z3"/>
    <dbReference type="STRING" id="759272.G0S4Z3"/>
    <dbReference type="GeneID" id="18257257"/>
    <dbReference type="KEGG" id="cthr:CTHT_0032190"/>
    <dbReference type="eggNOG" id="KOG1494">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047181_1_0_1"/>
    <dbReference type="OMA" id="ASCAEYI"/>
    <dbReference type="OrthoDB" id="4069699at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01337">
        <property type="entry name" value="MDH_glyoxysomal_mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000013">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000001">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010097">
        <property type="entry name" value="Malate_DH_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01772">
        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF73">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="13">
        <location>
            <begin position="21"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="166"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="26"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="136"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS21364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="336" mass="35392" checksum="377284938DC58775" modified="2011-10-19" version="1">MFAPSMIQRRAFSASARQLSKVAVLGAAGGIGQPLSLLLKLNPRVSELALYDIRGAPGVAADVSHVNTKSTVKGYEPTPTGLAEALKGAKVVLIPAGVPRKPGMTRDDLFNTNASIVRDLAKACAESCPDANILIISNPVNSTVPICAEVFKNKGVYNPRRLFGVTTLDVVRASRFVSEIKGTDPADEKITVVGGHSGVTIVPLFSQSRHPELSSNAELVKRVQFGGDEVVKAKDGAGSATLSMAMAGARMADSILRAAEGEKGVIEPTFVDSPLYKDQGIDFFSSNVELGPNGVEKVLPVGPVDAIEEKLLEACFVDLKKNIEKGKAFVAQNPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>G0S565</accession>
    <name>G0S565_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0032410</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693680.1">
        <property type="nucleotide sequence ID" value="XM_006693617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S565"/>
    <dbReference type="GeneID" id="18257279"/>
    <dbReference type="KEGG" id="cthr:CTHT_0032410"/>
    <dbReference type="eggNOG" id="ENOG502RAGC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105938_1_0_1"/>
    <dbReference type="OMA" id="NEPRANV"/>
    <dbReference type="OrthoDB" id="4941431at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409306" evidence="1">
        <location>
            <begin position="18"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="213" mass="22720" checksum="B57F312AC6C407DD" modified="2011-10-19" version="1">MKFFTVIVSALSTLAAAAPAVTSTTTTDVAKRSTGEVVDKRAITFDLGLVNNFSGFQQVNLNYLLNINALQLNLLRSFAEINNFNVLQFQGLFQHQVFDLNSLLQLQALHTFLQIGQLGVLNGFDLAGLQLHFLNLGLLNNIGVIDLSQFIIPSVVGQVTSVARQNLLIPTATSAPSSSTTSSAVVVVDQPTATSNVVTAEEQEAQEGGSSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0S571</accession>
    <name>G0S571_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lysophospholipase</fullName>
            <ecNumber evidence="6">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0032470</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the lysophospholipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="6"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693686.1">
        <property type="nucleotide sequence ID" value="XM_006693623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S571"/>
    <dbReference type="STRING" id="759272.G0S571"/>
    <dbReference type="GeneID" id="18257285"/>
    <dbReference type="KEGG" id="cthr:CTHT_0032470"/>
    <dbReference type="eggNOG" id="KOG1325">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013227_1_0_1"/>
    <dbReference type="OMA" id="WALGRRF"/>
    <dbReference type="OrthoDB" id="6121437at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00147">
        <property type="entry name" value="cPLA2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF40">
        <property type="entry name" value="PATATIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 5 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLA2c" evidence="8">
        <location>
            <begin position="120"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="548"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS21390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="734" mass="81607" checksum="068198E8AB3EFF4A" modified="2011-10-19" version="1">MLFAFWLYPSDSHHHCHSLAHLNDGRHHTSSFHDRPSREYSPKEDEENETAWSRFVHSISNTTFIPSADALSDKVIDMLMPEWTKLIPGYIRKLQRELSLAPGSLAAEIWREAQDPYVHPEIRYAAKVRVSNDLCDEEKEFLARRKRMIVPALAKYLGVDEGDICPDDVPTIAMCGSGGGLRALVAGTGYFSAASEDGLFDCATYVSGVSGSCWLQSLYYSSVTGGSFLKAIDHLKTRLGTHIAYPPVAFNALTSSPTNKYLLSGLIEKLKGDPGAQVGLVDLYGMLLAARLLVPKGELGVHEKDFKLSNQHIYIKYGQNPLPIYTAVRHEIPESSSEVEEETKAQAQAQAKKDAWFQWFEMTPYEFFCEEFSAGIPTWALGRKFNNGSDVPSPTAEGSTRLPEIRLPLLLGIWGSAFCATLSHYYREIRPLVKNLTGFAALDDLIWAYDKDMSVVHPIEPAAIPNPVYGMHGRLPQSVPKGVLDNEFIQLMDAGMSNNLPIYPLLRPGRNVDLIIAFDSSADIKTDNWLSIVEGYAKQRGIKGWPVGIGWPKEDESPSRTAAELSQAERAAETTPSPQPPASQAPIEPSRNIPFEQSVQQKASKTLGYCTIWVGTTLTSSTPTPATPISPTTISHLLHPHAGIAVAYFPLLANEKVAPGVDVATSEFMSTWNFVYTPEQVEQVVRLARGNFAEGRDQLKRVVRAIYERKRKARLEREQAERERRLVWGFGEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0S579</accession>
    <name>G0S579_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TAP42-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0032550</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693694.1">
        <property type="nucleotide sequence ID" value="XM_006693631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S579"/>
    <dbReference type="STRING" id="759272.G0S579"/>
    <dbReference type="GeneID" id="18257293"/>
    <dbReference type="KEGG" id="cthr:CTHT_0032550"/>
    <dbReference type="eggNOG" id="KOG2830">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041824_2_0_1"/>
    <dbReference type="OMA" id="EYELCEA"/>
    <dbReference type="OrthoDB" id="10261753at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051721">
        <property type="term" value="F:protein phosphatase 2A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035303">
        <property type="term" value="P:regulation of dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.540">
        <property type="entry name" value="TAP42-like family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038511">
        <property type="entry name" value="TAP42/TAP46-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007304">
        <property type="entry name" value="TAP46-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933:SF9">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04177">
        <property type="entry name" value="TAP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="42840" checksum="3674DDC287A1AF4A" modified="2011-10-19" version="1">MDEPRSLKALWADAEAKRLSLETTSFPPMSTDYRDAVSSAITLYNDCLTLISKLSLFSPNESLEDLHTNDLPFLLTNFYLAELTQKLPSSGASERKHLVSAARDAYERFLHLLDSYGLLSQQYKKLLEQYHDSPTTFSTIPAASDPVSRRNAKIANYRQEKELKAKLEYLRSRPGYGAGEEAEDGKQDGGDEDLVRQVHLAHLEYSVHMTFQALESLNREWEILAMAPPEPSEAQKAQQQAAEEDARRRQQQERNKDGYSEKLDPPLQYGPGSRIPGGPLLSTDGKPLRPFTLVNSRQEIAKGVFRPGHNLPTMTIDEYLEEERRRGGIIEGGGEKSWQQPEPDEDNIEKADEETMKAREWDEFIENNPKGSGNTLNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5B2</accession>
    <name>G0S5B2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Small COPII coat GTPase SAR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Small COPII coat GTPase sar1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">CTHT_0024190</name>
    </gene>
    <organism evidence="28">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable lipid hydrolase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">COPII-coated vesicle membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PLPL family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the small GTPase superfamily. SAR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692881.1">
        <property type="nucleotide sequence ID" value="XM_006692818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5B2"/>
    <dbReference type="STRING" id="759272.G0S5B2"/>
    <dbReference type="GeneID" id="18256457"/>
    <dbReference type="KEGG" id="cthr:CTHT_0024190"/>
    <dbReference type="eggNOG" id="KOG0077">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2214">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009031_2_0_1"/>
    <dbReference type="OMA" id="PRTRFMD"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07232">
        <property type="entry name" value="Pat_PLPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00879">
        <property type="entry name" value="Sar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000161">
        <property type="entry name" value="Small COPII coat GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF66">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE PTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51422">
        <property type="entry name" value="SAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="20" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="18 22" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11 24" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15 24" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="17 24" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="23" id="KW-0460">Magnesium</keyword>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PNPLA" evidence="26">
        <location>
            <begin position="507"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="24">
        <location>
            <begin position="538"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="248"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="24">
        <location>
            <position position="540"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="24">
        <location>
            <position position="687"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00007507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00021124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="EGS20585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="852" mass="95663" checksum="FCC6D3C16205F3E6" modified="2011-10-19" version="1">MFLINWIWDFLASLGLTNKHGKLLFLGLDNAGKTTLLHMLKNDRVAILQPTLHPTSEELTIGNVRFTTFDLGGHQQARRLWKDYFPEVNGVVFLVDAKDHERFPEAKAELDALLAMEDLAKVPFVILGNKIDHPDAVSEDELRHHLGLYQTTGKGKVPLEGIRPIEVFMCSVVMRQGYGEAIRWLSHPIGSPLGRYSAVFDLSSVKILRNSYGFAPEEFDPTLLPDVDIEFVQPDHLDAFSRALAAPSGASGNSSAPACSSRVPATGEVQREGELAPVLQAPAPSPAEMYEDPILGLRRQRHYRPRQPRRPSIDDVRASLGHSLLRWPLLVLVLAYLALLCAAYSATRALIRLTEVWRIWGNAARLRREMARARTYQEWVHLAVAMDHILGLEDWKWREESRLYDAGTVKEVVLGLDVALPRARGGEPGALEEVRRLVEACVKRDFAGVENARIYSRTHVGTKKLVERFVDQVEESLNLLASTGSIPALEKRAFFKRLSANYGRTALCLSGGATFAYHHFGVVRALLEEDVLPDIITGTSGGALVASLVGTRTDDELRQLLVPALATRITACADSLYVWLIRWWRTGARFDPVEWARLCSWWTRGSLTFREAYERTGRILNISCVPADDPHSPPLLCNYLTAPDCVIWSAVLASAAVPGLLPPVVLMNKNLHTDELTPFSLGTRWRDGSLRTDIPLRALNNLFNVTFSVVSQTNPHINTFFFPARGSVGQPVAHRQGRGWRGGFLLSALEHIIRLDLHKWLRFLRSMDILPRWLGQDWSNLWLQSALLGTITVWPAGGHISDYFNILTDPDAERLARMIRDGMLTMWPAIHFIRNRLRVERAVERGRGLCRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5J1</accession>
    <name>G0S5J1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tetracycline:hydrogen antiporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0033140</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693752.1">
        <property type="nucleotide sequence ID" value="XM_006693689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5J1"/>
    <dbReference type="GeneID" id="18257352"/>
    <dbReference type="KEGG" id="cthr:CTHT_0033140"/>
    <dbReference type="eggNOG" id="KOG2615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_54_5_1"/>
    <dbReference type="OMA" id="AWWACGI"/>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="507"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="23"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="252"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS21456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="553" mass="60727" checksum="A0286526C065A415" modified="2011-10-19" version="1">MRARSRKQRSSRGVQRPPYPSRQLLILAACRICEPIAFMSIFPYIYHMVKDFNITNDESKISFYAGMVTSAFTFAEFSTGFLWGRLSDKIGRKPVLLMGMGGTGLSVLIFGFAPSLKVALFARALGGFLNGNMGVLQTTVAELVTVKEHQPRAYSVMPLVWCIGSIVGPMIGGALAKPVESMPSIFKPGSIFDRFPYLLPNLFSAVCVLIGVIIGILFLEETHAERKKHRDPGLELGKAILVWLPIQSCRNREPAKKPEEQPLLFDTDEPLPGYLTNEDSDASFETDSDPAEPVDVERLERTLNEQVSATEAVKSTGKIFTKPIITIIASYGVLAFHTMAFDSLLPVFLSTNPPKDGIPMKLPFKFSGGFGLDTQTIGVILSVQGLYSMFATKVLFPAITEKMGPRRVFQLMSILYPLLYFCTPYIVLLPPSLHKVSIYALIIWKCSITTLAYPSNAILLSNSAVSTLTLGTINGAAASTASFCRAMSPIVSGSLYTMGLESGYSGLVWWFTMLITFGGAYIGLKIKEPRGRLDEKDDIEVSPEADSRQLTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5P9</accession>
    <name>G0S5P9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0025040</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692964.1">
        <property type="nucleotide sequence ID" value="XM_006692901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5P9"/>
    <dbReference type="STRING" id="759272.G0S5P9"/>
    <dbReference type="GeneID" id="18256542"/>
    <dbReference type="KEGG" id="cthr:CTHT_0025040"/>
    <dbReference type="eggNOG" id="ENOG502SX2A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052402_0_0_1"/>
    <dbReference type="OMA" id="YFFRASH"/>
    <dbReference type="OrthoDB" id="4140442at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="362" mass="40496" checksum="56316D2628CC0738" modified="2011-10-19" version="1">MLRARFFTTSCRWFKQKPPTRLPWPPKPVKPGNTAIKAAEAPSNPTSGQITVSTATVAHTAISKAASTPAPTPKPVASSKPLPFLPPDGIPATYAERLASRGRTLLYEAPSHFWFRAGCFSSGAFCASYTVYQYWTVILHPPEGLLWWVPHAFGVILVFMSGMAAYFIMGTGRIVRTIEAVPWRQVFGEGVPKKKPWMSKAVKKSLQTTSPQEGAKKVLVEVATRGMIPFWPAKKRLYLPEEIQLPMRMNSVYGSGAIGGAGPQNNEYLSLAERVRRERALREAREAERKYNMDHILTAPFRDARKVFRGMFKGIRRSFDREGFVKIKLGDEKYKLDVTGGWALDEGRAMDRLLAVRPNALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5S8</accession>
    <name>G0S5S8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CTHT_0033480</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="21 22 23" key="2">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e56910" last="e56910">
            <title>Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation during pre-60S biogenesis.</title>
            <authorList>
                <person name="Lau B."/>
                <person name="Huang Z."/>
                <person name="Kellner N."/>
                <person name="Niu S."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
                <person name="Cheng J."/>
            </authorList>
            <dbReference type="PubMed" id="37129998"/>
            <dbReference type="DOI" id="10.15252/embr.202356910"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.80 ANGSTROMS)</scope>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693786.1">
        <property type="nucleotide sequence ID" value="XM_006693723.1"/>
    </dbReference>
    <dbReference type="PDB" id="8I9T">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.60 A"/>
        <property type="chains" value="Cb=1-924"/>
    </dbReference>
    <dbReference type="PDB" id="8I9V">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="Cb=1-924"/>
    </dbReference>
    <dbReference type="PDB" id="8I9W">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="Cb=1-924"/>
    </dbReference>
    <dbReference type="PDB" id="8I9X">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="Cb=1-924"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5S8"/>
    <dbReference type="EMDB" id="EMD-35283"/>
    <dbReference type="EMDB" id="EMD-35285"/>
    <dbReference type="EMDB" id="EMD-35286"/>
    <dbReference type="EMDB" id="EMD-35287"/>
    <dbReference type="SMR" id="G0S5S8"/>
    <dbReference type="STRING" id="759272.G0S5S8"/>
    <dbReference type="GeneID" id="18257386"/>
    <dbReference type="KEGG" id="cthr:CTHT_0033480"/>
    <dbReference type="eggNOG" id="KOG0337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_5_0_1"/>
    <dbReference type="OMA" id="EDQFGMM"/>
    <dbReference type="OrthoDB" id="10261375at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17959">
        <property type="entry name" value="DEADc_DDX54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000865">
        <property type="entry name" value="ATP-dependent RNA helicase DDX54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012541">
        <property type="entry name" value="DBP10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033517">
        <property type="entry name" value="DDX54/DBP10_DEAD-box_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF8">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08147">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01123">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="21 22 23" id="KW-0002">3D-structure</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="18">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="121"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="342"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="335"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="623"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="841"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="880"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="14">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="624"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="661"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="695"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="880"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGS21490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="21">
        <source>
            <dbReference type="PDB" id="8I9T"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="22">
        <source>
            <dbReference type="PDB" id="8I9V"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="23">
        <source>
            <dbReference type="PDB" id="8I9W"/>
        </source>
    </evidence>
    <sequence length="924" mass="102822" checksum="A3B4416E1F7987C7" modified="2011-10-19" version="1">MPKRAVSPAPSENEVDIAGSLFANELDSDSDAPKANPGTATDLDFGDLLNATHDGGSDDDSGDEAFIDLHQRSSNRKSSNLQGKTVKKGGGFQAMGLDANLLRAIARKGFSVPTPIQRKTIPLILERRDVVGMARTGSGKTAAFVIPMIERLKAHSARFGARALVLSPSRELALQTLKVVKELGKGTDLKTVLLVGGDSLEEQFGLMATNPDIIIATPGRFLHLKVEMSLDLSSIKYVVFDEADRLFEMGFAAQLTEILHALPPSRQTLLFSATLPSSLVEFTRAGLQDPVLVRLDAETKVSPDLESAFFSVKSGEKEGALLHILYDIIKMPLGDPPRSENDEEQPKSKKRKRGSDKPNFKEKPTEHSTIIFTATKHHVEYISNLLRLAGFSVSYVYGSLDQTARKIQVDNFRRGRTNILVVTDVAARGIDIPVLANVINYDFPPQPKIFVHRVGRTARAGQRGWAYALVRESDLPYLLDLQLFLGRRLVLGREEKDPSFARDIVVGSLKRVELENNVEWVNKVLHENEDIGALKRVTAKAEKLYMKTRNPASSQSAKRAREVIVSKGWGQLHAIFGEEAANEEQVRDNLLSKITGYKPQETIFEIGPKGKVSQNKAAEAVRSFRQRIGPRKLPKQDEDTEMVDAEALPDHVGNAERKGQEEEESVDEDGATQDSVLWKHDSNSDSNSESELEVTVTNSAKAKKGQTSFADPEVYMSYTPRTTSLAEEHAYGVHSGGVRSSNFVEAARDATMDLTNDEGAKGFGLPSRPKYRWDKRHSKYVSTANDDDGSKGVKMIRGESGVKIAASFKSGRFEKWRQQHRLGRLPQVGEMEKANLVRNFSLPSGPRFKHKQMKAPKEADKWRDDYEVRKKRVAEAKEKRIGKFKDGEGNRRELKTESDIRKAKELKERRKEKNARPSKKPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5V7</accession>
    <name>G0S5V7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0033780</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693815.1">
        <property type="nucleotide sequence ID" value="XM_006693752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5V7"/>
    <dbReference type="STRING" id="759272.G0S5V7"/>
    <dbReference type="GeneID" id="18257416"/>
    <dbReference type="KEGG" id="cthr:CTHT_0033780"/>
    <dbReference type="eggNOG" id="ENOG502S4CD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009124_1_0_1"/>
    <dbReference type="OMA" id="TVQACVF"/>
    <dbReference type="OrthoDB" id="1749473at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="238"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="686"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="741"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="769"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="797"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS21519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="844" mass="92084" checksum="0D56552717C55ADB" modified="2011-10-19" version="1">MPDPQPPAPFLGPVSAGSSQPESSQSQSSHYSRRARPPDPRSDMGDAEKVPLKLDVGEKAHKRESRLGLRSLFARGRGGLDVRDPSQKSSGLRASLAELSWPYSSHHAQGHRSELSLPTVPKSPLPGQNLRHKKSASAVRTQSTTDGLAAWNPPPLFQAYPQAIKSARLPACTASAETVLRLYNHKSNGSLVGVLSPGTSDIPGESAGSEKTDKPRRKHRRNLSGSTSKFEWTTKEYVLVTSGYLLQYSGEGAFDRLPEKVLQLGKESAAFASDVIPGRHWVIQVSSVVEPERVPTSHSSLRSRFPFRGSEKKYSSTMLMVCESAEDMESWLTTLRRTIENLGGRKILSETGKPKHDDEDPRLKNQASQRTLVVKDPDRFSRVLSPEKRWSRTGTVNLDSHHEHHDDPARDQSRDDTSTLSFISHDGRQLDSLRDSTNRLSYMSSGQRTMLTSTGSSPACSPIRDSFLDLDPPASELPPLEEQKPRPRPNAMAIVNRRQSLQAINHVVEMRIAASQPTGPLAGLLNPSPSDAPSQHTVPNFSMPHGLNKRHSLGKGPQNGPSNPSSPLSPPRVSARRPPPSAIAINPRPLSLVIDQPSPGVSPSIGGQMESEKTESPPSDTPNTLSIPSASLQQEDSDELPQTDAVGLSEDTDLIPNGQPFNNTITEHNVRWPFLELHEIPRCHTSLGTYGGIRETDSRAPMQSMRSRRLSFTSPRDTIGPCPPSDTSQRPRTPSLKPMPRSQQLRANAHYQQQPIVTKPQSMSQLVEGPPPAPPPNRALPLPPVASPPLKQRRAFSPPPPPQPPASAYAVPPPKAPPPNRALPPIPQKLPLRTDLNSPPPGFI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2014-10-29" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0S616</accession>
    <name>MRT4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Ribosome assembly factor mrt4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">mRNA turnover protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0025680</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="3491" last="3491">
            <title>60S ribosome biogenesis requires rotation of the 5S ribonucleoprotein particle.</title>
            <authorList>
                <person name="Leidig C."/>
                <person name="Thoms M."/>
                <person name="Holdermann I."/>
                <person name="Bradatsch B."/>
                <person name="Berninghausen O."/>
                <person name="Bange G."/>
                <person name="Sinning I."/>
                <person name="Hurt E."/>
                <person name="Beckmann R."/>
            </authorList>
            <dbReference type="PubMed" id="24662372"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS)</scope>
        <scope>IDENTIFICATION OF FRAMESHIFT</scope>
        <scope>SEQUENCE REVISION TO 13; 139; 228 AND 259</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associates with the pre-60S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">Shuttles between the nucleus and the cytoplasm.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="sequence caution" evidence="3 4">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EGS20732" version="1"/>
        </conflict>
    </comment>
    <comment type="sequence caution" evidence="3 4">
        <conflict type="frameshift">
            <sequence resource="EMBL-CDS" id="EGS20732" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20732.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693028.1">
        <property type="nucleotide sequence ID" value="XM_006692965.1"/>
    </dbReference>
    <dbReference type="PDB" id="4NWB">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.80 A"/>
        <property type="chains" value="A=1-270"/>
    </dbReference>
    <dbReference type="PDB" id="8I9T">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.60 A"/>
        <property type="chains" value="CF=1-270"/>
    </dbReference>
    <dbReference type="PDB" id="8I9V">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="CF=1-270"/>
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    <dbReference type="PDB" id="8I9W">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="CF=1-270"/>
    </dbReference>
    <dbReference type="PDB" id="8I9X">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="CF=1-270"/>
    </dbReference>
    <dbReference type="PDB" id="8I9Y">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="CF=1-270"/>
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    <dbReference type="PDB" id="8I9Z">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="CF=1-270"/>
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    <dbReference type="PDB" id="8IA0">
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        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="CF=1-270"/>
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    <dbReference type="PDB" id="8PV1">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.56 A"/>
        <property type="chains" value="CF=1-270"/>
    </dbReference>
    <dbReference type="PDB" id="8PV2">
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        <property type="resolution" value="2.63 A"/>
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        <property type="resolution" value="2.80 A"/>
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        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
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    <dbReference type="PDB" id="8PV5">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.86 A"/>
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    <dbReference type="PDB" id="8PV6">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.94 A"/>
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    <dbReference type="PDB" id="8PV7">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.12 A"/>
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        <property type="method" value="EM"/>
        <property type="resolution" value="2.91 A"/>
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        <property type="resolution" value="2.55 A"/>
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        <property type="resolution" value="2.19 A"/>
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    <dbReference type="PDBsum" id="8IA0"/>
    <dbReference type="PDBsum" id="8PV1"/>
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    <dbReference type="PDBsum" id="8PV8"/>
    <dbReference type="PDBsum" id="8PVK"/>
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    <dbReference type="AlphaFoldDB" id="G0S616"/>
    <dbReference type="EMDB" id="EMD-17950"/>
    <dbReference type="EMDB" id="EMD-17951"/>
    <dbReference type="EMDB" id="EMD-17952"/>
    <dbReference type="EMDB" id="EMD-17953"/>
    <dbReference type="EMDB" id="EMD-17954"/>
    <dbReference type="EMDB" id="EMD-17955"/>
    <dbReference type="EMDB" id="EMD-17956"/>
    <dbReference type="EMDB" id="EMD-17957"/>
    <dbReference type="EMDB" id="EMD-17969"/>
    <dbReference type="EMDB" id="EMD-17970"/>
    <dbReference type="EMDB" id="EMD-35283"/>
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    <dbReference type="EMDB" id="EMD-35286"/>
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    <dbReference type="EMDB" id="EMD-35289"/>
    <dbReference type="EMDB" id="EMD-35290"/>
    <dbReference type="SMR" id="G0S616"/>
    <dbReference type="STRING" id="759272.G0S616"/>
    <dbReference type="GeneID" id="18256606"/>
    <dbReference type="KEGG" id="cthr:CTHT_0025680"/>
    <dbReference type="HOGENOM" id="CLU_071690_3_0_1"/>
    <dbReference type="OrthoDB" id="10262308at2759"/>
    <dbReference type="EvolutionaryTrace" id="G0S616"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05796">
        <property type="entry name" value="Ribosomal_P0_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000005">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000003">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033867">
        <property type="entry name" value="Mrt4"/>
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    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051742">
        <property type="entry name" value="Ribosome_Assembly_uL10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841:SF1">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 MRTO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000430590" description="Large ribosomal subunit protein uL10">
        <location>
            <begin position="1"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="234"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="257"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; EGS20732." ref="1">
        <original>T</original>
        <variation>I</variation>
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; EGS20732." ref="1">
        <original>P</original>
        <variation>T</variation>
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; EGS20732." ref="1">
        <original>S</original>
        <variation>N</variation>
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; EGS20732." ref="1">
        <original>M</original>
        <variation>I</variation>
        <location>
            <position position="259"/>
        </location>
    </feature>
    <feature type="helix" evidence="6">
        <location>
            <begin position="8"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="helix" evidence="6">
        <location>
            <begin position="26"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="helix" evidence="6">
        <location>
            <begin position="34"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="strand" evidence="6">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="helix" evidence="6">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="turn" evidence="6">
        <location>
            <begin position="60"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="strand" evidence="6">
        <location>
            <begin position="63"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="helix" evidence="6">
        <location>
            <begin position="70"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="turn" evidence="6">
        <location>
            <begin position="81"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="helix" evidence="6">
        <location>
            <begin position="89"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="strand" evidence="6">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="helix" evidence="6">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="strand" evidence="6">
        <location>
            <begin position="121"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="strand" evidence="6">
        <location>
            <begin position="135"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="strand" evidence="6">
        <location>
            <begin position="139"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="turn" evidence="6">
        <location>
            <begin position="144"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="helix" evidence="6">
        <location>
            <begin position="151"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="helix" evidence="6">
        <location>
            <begin position="159"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="helix" evidence="6">
        <location>
            <begin position="162"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="strand" evidence="6">
        <location>
            <begin position="172"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="strand" evidence="6">
        <location>
            <begin position="178"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="strand" evidence="6">
        <location>
            <begin position="192"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="helix" evidence="6">
        <location>
            <begin position="203"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="strand" evidence="6">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
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        <location>
            <begin position="229"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="strand" evidence="6">
        <location>
            <begin position="234"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="helix" evidence="6">
        <location>
            <begin position="238"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P33201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="24662372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="EMBL" id="EGS20732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="4NWB"/>
        </source>
    </evidence>
    <sequence length="270" mass="30480" checksum="2458BF4ED266B410" modified="2014-10-29" version="2">MPKSKRARVYHLTQVNKKGREAKERLFSNIRETIPKYQHCFVFSVDNMRNNYLKDVRHELNDCRIFFGKTKLMARALGTTPEEEQADGLHRLTRYLTGTVGLLFTNRDPADIESYFSNLSQVDFARAGTVAPRTVTVPPGIVYSTGGEVPPEHDVPVSHTLEPELRRLGMPVRMIKGKVCLGDEKGEASEGYTICKEGEVLDSRQTRLLKLFSICLSEFKVSLLGYWSSASGEVTELEAGKTRPKREGNRRQAMNGDEMDEDQSSDEDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6D9</accession>
    <name>G0S6D9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribonuclease P/MRP protein subunit POP5</fullName>
            <ecNumber evidence="4">3.1.26.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0034570</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP, which cleaves pre-rRNA sequences.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic/archaeal RNase P protein component 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="4"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693890.1">
        <property type="nucleotide sequence ID" value="XM_006693827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6D9"/>
    <dbReference type="STRING" id="759272.G0S6D9"/>
    <dbReference type="GeneID" id="18257495"/>
    <dbReference type="KEGG" id="cthr:CTHT_0034570"/>
    <dbReference type="eggNOG" id="KOG4639">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086710_1_1_1"/>
    <dbReference type="OMA" id="IVRCPRA"/>
    <dbReference type="OrthoDB" id="24745at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030681">
        <property type="term" value="C:multimeric ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3250:FF:000004">
        <property type="entry name" value="Ribonuclease P/MRP protein subunit POP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3250">
        <property type="entry name" value="Ribonuclease P, Pop5 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002759">
        <property type="entry name" value="Pop5/Rpp14/Rnp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038085">
        <property type="entry name" value="Rnp2-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15441">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15441:SF2">
        <property type="entry name" value="RIBONUCLEASE P_MRP PROTEIN SUBUNIT POP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01900">
        <property type="entry name" value="RNase_P_Rpp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160350">
        <property type="entry name" value="Rnp2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS21594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="197" mass="21381" checksum="D6D25A059F475655" modified="2011-10-19" version="1">MVRLKDRYLLVNIIYTDVLPGQSRASVPDVLLYNQPTTGELRPQMLVKAIRGEVAALFGDCGSGAVDRSLQVKYLSPATSTFILRVSRAHYRLVWAALSFMNQVPVKNGRPCIFRVVRVSGTMRKIEEEAVRRAKLLILAAKDEMASKNGSSSSSADALGALLRSDSLASRTLAVRSGQDDSGLVCGYEDKDTSGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6F7</accession>
    <name>G0S6F7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0034760</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693908.1">
        <property type="nucleotide sequence ID" value="XM_006693845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6F7"/>
    <dbReference type="STRING" id="759272.G0S6F7"/>
    <dbReference type="GeneID" id="18257514"/>
    <dbReference type="KEGG" id="cthr:CTHT_0034760"/>
    <dbReference type="eggNOG" id="ENOG502RNIV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022672_1_0_1"/>
    <dbReference type="OMA" id="WTFDTWN"/>
    <dbReference type="OrthoDB" id="2527403at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018803">
        <property type="entry name" value="Ish1/Msc1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47372">
        <property type="entry name" value="DAUER UP-REGULATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47372:SF11">
        <property type="entry name" value="RE19971P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10281">
        <property type="entry name" value="Ish1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409346" evidence="1">
        <location>
            <begin position="20"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="553" mass="61775" checksum="47FB232F20331DC7" modified="2011-10-19" version="1">MRIVKALISLALVADVTLASSWLSKAAYNKWHETELERWLSDNNIPYPTPADRKELERLVQANWDTHVVTPYRDWDANRLTEYLKRKGVETKESAENARDSLISQVKNYWYETEDKAQAGWTNVKDWILDTWSDSQLKAFCDRHGIPVPQPHKRDTLLQKVRENFHTIAEKLGETASYPGDWLYETWTESDLKEWLDTHGFPAPQPTTRDKLIASVRRNSRLAYLRMQEEAERSRSKVQEAYATLTDKLIDAWGESQLKEFCDKNGIKVPQGTKLNELRALVRKHRAEIMGDTVADSAASAFGAATSSIGSAASRATDAAARATDAAAQAIQDAFDKAINTWSDSRLKAFLDARGVPVPQGSKTNELLALVRKHAHKAASGWTAWTWDDLTTDNLREYLKSSGNAAARKIADKSDATREELVAAAKRTYASASSAGGSIYASATNYLAKATDSAKESLFDTWSESELKAYLDSYGVPVPQGSTVNELRALARRQYTYFKYGTSSPSSPAYAKIKEVLLNGWQWVANQLKLGSEAARDKAAEQEKAAKKAHQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6S8</accession>
    <name>G0S6S8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="9">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0035460</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Lipid-anchor</topology>
            <topology evidence="1 9">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="9"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693976.1">
        <property type="nucleotide sequence ID" value="XM_006693913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6S8"/>
    <dbReference type="STRING" id="759272.G0S6S8"/>
    <dbReference type="GeneID" id="18257584"/>
    <dbReference type="KEGG" id="cthr:CTHT_0035460"/>
    <dbReference type="eggNOG" id="ENOG502QRZZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021855_1_0_1"/>
    <dbReference type="OMA" id="MRAYIKA"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000032">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF5">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 9" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9 11" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005130804" description="1,3-beta-glucanosyltransferase" evidence="9">
        <location>
            <begin position="22"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="381"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="413"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS21680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="453" mass="49505" checksum="621218AF1AB72438" modified="2011-10-19" version="1">MKSLALVSALAATNAVHGSLAASVRHKPRAEIEPITIKGNAFFQGNKRFYIRGLDYQPGGSSANVDPLADPKICLKDIEKFKKLGINVIRVYSTDNSKDHDECMNALADAGIYVVLDANNPLYSINRNDPHGSYNTPYLQSVFATIDAFAKYPNTMAFFSGNEVIHDLKNTTLTAPYVKATDRDMRAYIKARGYRKIPVGYSAADVSTNRMQTAHYFNCGSDEERSDFFAFNDYSWCTSDFVTSGWNKKVEAFKDYGIPIFLSEYGCNHNKRNFGELESLMHRNMTSVYSGGLMYEYSMEENKYGIVQIKGGEKGSKDQTGERIELEEFAAFANALKKYPAPDDDGGYNPVSKASACPPADDHWDVHTEKLPAMPEGARKFLKEGAGKGPGLNGPGSQWAVDQASSSTPGTFEDSDGSSDSSDSDESAAVRGTVGYAAFVISGVAMLLGALAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6Y9</accession>
    <name>G0S6Y9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative tRNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0035530</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693983.1">
        <property type="nucleotide sequence ID" value="XM_006693920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6Y9"/>
    <dbReference type="STRING" id="759272.G0S6Y9"/>
    <dbReference type="GeneID" id="18257591"/>
    <dbReference type="KEGG" id="cthr:CTHT_0035530"/>
    <dbReference type="eggNOG" id="KOG2241">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009710_6_6_1"/>
    <dbReference type="OMA" id="QVCRTVC"/>
    <dbReference type="OrthoDB" id="19141at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10304">
        <property type="entry name" value="GST_C_Arc1p_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02799">
        <property type="entry name" value="tRNA_bind_EMAP-II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000199">
        <property type="entry name" value="tRNA-aminoacylation cofactor ARC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053836">
        <property type="entry name" value="Arc1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051270">
        <property type="entry name" value="Tyrosine-tRNA_ligase_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586:SF33">
        <property type="entry name" value="AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586">
        <property type="entry name" value="TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21972">
        <property type="entry name" value="Arc1p_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="GST C-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="TRNA-binding" evidence="6">
        <location>
            <begin position="212"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="146"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS21687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="406" mass="42999" checksum="E9D5BA3B11B6FC6A" modified="2011-10-19" version="1">MAALGAQKYTPAEESEIQAWLARAQELKAGASDAALDALNAELATRTTALGTKPSKADIALYESLAPIVKSWAPEQRTGENGRPNIVRLVDFVQNSPIFGLDVADADKVQVDPEEILYVKPPADPKAEKERLKKEKAAAAAAAAASAATGNQALPDRTKEKNAGAAVEPKDKVADTTPAAAEGGNGKPKKEKKEKKERAPKQAPPPAPTVLSPGLIDLRVGHILKAIKHPEADSLYVSTINVGDKPGTDDTVEYEGQICRTVCSGLNGLVPLEEMQGRKVVVVCNLKPVKMRGIKSCAMVLAASPRPKEGEDDHKGPVELVNPPADAKAGERVFFEGFQAEPEKVLNPKKKIWETFQPGFTTTDSLEVAFDPSVVEALEGKTGLAKLVTESGGVCTVASLKGAQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G0S702</accession>
    <name>G0S702_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0035660</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693996.1">
        <property type="nucleotide sequence ID" value="XM_006693933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S702"/>
    <dbReference type="GeneID" id="18257604"/>
    <dbReference type="KEGG" id="cthr:CTHT_0035660"/>
    <dbReference type="HOGENOM" id="CLU_2026459_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="122" mass="12550" checksum="3FB6FDF8F8E0DD6D" modified="2011-10-19" version="1">MSDAFPEGGDLSTMAKEGTKVPSKPSMPEATPSAQSKTTKSKAASGGISSSPEELQDEDIVTAVGGEIPEDLGRWGAKAPVSLGPTLRFNVVSTRGRTSSTAEAMELALQIPIALSLSPHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0S770</accession>
    <name>G0S770_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TBP-associated factor 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Transcription initiation factor TFIID subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0027640</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693221.1">
        <property type="nucleotide sequence ID" value="XM_006693158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S770"/>
    <dbReference type="STRING" id="759272.G0S770"/>
    <dbReference type="GeneID" id="18256802"/>
    <dbReference type="KEGG" id="cthr:CTHT_0027640"/>
    <dbReference type="eggNOG" id="KOG2549">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021711_3_0_1"/>
    <dbReference type="OMA" id="YFVQFIA"/>
    <dbReference type="OrthoDB" id="361039at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22931">
        <property type="entry name" value="HFD_TAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08050">
        <property type="entry name" value="TAF6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000033">
        <property type="entry name" value="Transcription initiation factor TFIID complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.770">
        <property type="entry name" value="TAF6, C-terminal HEAT repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037796">
        <property type="entry name" value="TAF6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011442">
        <property type="entry name" value="TAF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046344">
        <property type="entry name" value="TAF6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02969">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07571">
        <property type="entry name" value="TAF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="8">
        <location>
            <begin position="10"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00076308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS20925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="480" mass="52410" checksum="77844236A3E74824" modified="2011-10-19" version="1">MATNEGPKLLWNPENVRDVADALGITLSEEPLRLLAQDVEYRIGQVIVESLRFMRAANRTTLTVQDVSLALRVLDVEPLYGYESTRPLRYGEASLGPGQPLFYIDDEEVDFEKVINAPLPKVPRDMTFTAHWLAVEGVQPSIPQNPTTAETSSKDLLPKGPGANPALAALAGNDNVSFRPSVKHVISKELILYFDKIQAAILDDDPDEEKMRLRQAALESVRSDPGLHQLLPYFVNFITNQVTHHLDDLFILRQMMELAEAVVQNPTLFIDPYASALAAPVLTCLMSRKLGKNPSSNDEGALGAGNSIDSTLREQYSLRELAASLLSMIARKYGASNALLRPKLTRTCLKHFLDPTRPPAVLFGAISGVAASGGPEAVRVLVLPNLKTFDSAVLQPLREKAGPVAELEYEMLVGGIVKAVQSIVGDQAALGALTNGINGADLTREGEQVIEFLGPIVGQRIAQLRNHTLNRSILEVRHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7H7</accession>
    <name>G0S7H7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hypercellular protein hypA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0028180</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693275.1">
        <property type="nucleotide sequence ID" value="XM_006693212.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S7H7"/>
    <dbReference type="GeneID" id="18256856"/>
    <dbReference type="KEGG" id="cthr:CTHT_0028180"/>
    <dbReference type="eggNOG" id="KOG1953">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002231_0_0_1"/>
    <dbReference type="OMA" id="EGFWYRE"/>
    <dbReference type="OrthoDB" id="27962at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058565">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058567">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058568">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058564">
        <property type="entry name" value="TPR_TRAPPC9_Trs120"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013935">
        <property type="entry name" value="Trs120_TRAPPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058563">
        <property type="entry name" value="Trs120_TRAPPC9_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512:SF5">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26254">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26280">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26282">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26283">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26251">
        <property type="entry name" value="TPR_TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08626">
        <property type="entry name" value="TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trs120/TRAPPC9 N-terminal" evidence="4">
        <location>
            <begin position="6"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 TPR region" evidence="5">
        <location>
            <begin position="432"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 first Ig-like" evidence="6">
        <location>
            <begin position="752"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 third Ig-like" evidence="7">
        <location>
            <begin position="1088"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 fourth Ig-like" evidence="8">
        <location>
            <begin position="1279"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="217"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF26254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF26282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF26283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS20979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1441" mass="158481" checksum="BBF086AE4F526433" modified="2011-10-19" version="1">MTLDPLLPLAPARVKALVLPIGHIRHDRFTSFVDHLNTENVVALRDVTPDARPHRNMFSPLVFPDGFMFFDLITHHPTPSHLALSPFDLWREPLAVIAIADGVELPNVVFSKRHSGGRSVEEANIRTLYQELEDLRDRYPKVLAHQVVIFDYKQAEENPVPIPEGIVTVPPAEESKRATIKTVMCDISSLILAEMTTLAKSYEGLAFIDSPGYSSGRYQNGGPGDDYLNRRNSQFTLPSRSNPSSSFTDRGNMRMSMPPVPSSRQPSGSSSSTPIRPSTPVGENKPLPAPPSTFDSIIGPPEPMSPEKGQDRVPVQGFGSGSSNERWRTKGRCRIQIVIGSLYLQAGLWNNALKELCEAAVVAKSMNDHLWHGKALELTLLSLLLLGWANLEFQVPAILHPPPEKGAAIAQAVQEAEARDPSQPRALRHLQVSILELVDRILGLYSRISAENLPPLPFCEAAIRFSRILTAVHIAGGTLGRESLDMMVLGKLPTKQLTTSPRFTVPPTRAQIMATLFRGFPASPSEMLTTADRIVLLSAIAAVLGQIGFQRKKALVLKELVSVLVGGLVEARTRGAADVGIHPAAGLAGVNGAAGAGAGGSGALELAEGDIEYGMDAFLGMLLKTYGVVEGANPNDPSRPPDDSNEAVIARIRKQSAARFFGIPGTKLEILRACINFSEALPDFAGVLKYSSDLLRTAGSGIAPGPRRENAFPVISREEQVRLFTNIMKTTNLSRRLGAGPLTAEYWDEFLLRGISLEPLPPMRAPVAHAKTVLPGITATARASQDVDPFIYNPFLKRPDTAAVDRTLVAGEPATFRLTLQNPYEIEVELESIRLDTEGAEFESAIESTVIGPYRTQTMRITGTPKAAGTVKITGAIIKPRGCRERRFPIFTDPWAPEDVTKVKSIGLGALDTNAKVVTPAIQRLKPDHIEVNVVAPQPFVVIKSSTLPQSSVMILEGERQRFSITLENLSTTTPVDFLLFSFKDSTQEPLQAAINSRDATATDLYEYELILAKKHAFRLRSRNDNKRFIPPGGTATFDFEILGRPGLTHGLIQVDYAYLGVPHDEVAEKFYTRQVSMELTVTVNASVEITRVDVLPLTGRIPDPLWSRVSSEPAEKCLAPDSHCLLLLDLRNSWPSQMTVALEASDGVRVEDHILPGHTSRVMLPIRRVYLEDPHAFIPAINPNRQRQFVVSTKISPEAERASREAFWYREKVLDTLKGTWRTTAPGNCATREGEIELRAIRFTPRMIEAIKIDELAIDISLATPSLNSDSTELSPITPASDDTASPEKRYVVPLDSFLALRVRLTNRSARPIYPLLRLTPSLAHRPFNVSLDFTRKLAKFAWNGTLQQALPLLPGNGGTMEVVMGVTALCRGEFEIAASVEETRLWVDAKELEEEKEREEIKQRTEMEAQAILLGNAIGKRERRVWHARRGCRLVVRDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8E2</accession>
    <name>G0S8E2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0029570</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693412.1">
        <property type="nucleotide sequence ID" value="XM_006693349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8E2"/>
    <dbReference type="STRING" id="759272.G0S8E2"/>
    <dbReference type="GeneID" id="18256995"/>
    <dbReference type="KEGG" id="cthr:CTHT_0029570"/>
    <dbReference type="eggNOG" id="ENOG502SJ1Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013199_0_0_1"/>
    <dbReference type="OMA" id="YVQEMPP"/>
    <dbReference type="OrthoDB" id="5333304at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="654"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="880"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="672"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="727"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="767"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="891"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="950" mass="104663" checksum="7C93D994B6170E0F" modified="2011-10-19" version="1">MAGASAVAVLPSTNTGEGRDEQPGSSSATSSNNLLASLKPEEQKELREYDKLLLFYDEVVRGQHPRIKLPEKAVVASGQPALEFLAPSVPLATTSQPATPSSAPAGDKSTVTSATTDRSAVVDSARAYQANQKAPRVPVQANNSASVSLPGLGNFPAPSSKSPSSSKPEAENKMPDGLQQEKDAIQKERERIEQRLREQLEQRRAAGKAGAEQLPDLDVADIFEKVMSQSQEAPAAASAAAQQQPVRATDHTAANASTSSAEPVSDNSTFYSSHLDTPESGLVARIPTSPSDTEMREASREGSPYEPELDEPVVIQAQPAPALAQAIPGIAPGQPVQQPQTYQGPGVAGPSRAYAPAGPSQLRDSARREEAYQQAMARPPSPRIYSHELSPVAPQPTHVLPPGITRRQEMRATASSSGSQATPAQVSALRKQGSNPSTPEGSPRQGSRGVEKKKKKKKRKADRAAENAAPSPYIKPEPRSPSPFSSRPAKRQKQSQNQQQQPVEIHDDEPARYEPPPPPARVDEGSQERYPPRVVRQERVVGYERADDYHHRYETSPRYQRVEAVYYDDCRAPPPPGSAYEYREVRTVRPASRLVEAQYEDGPGAAYYREVPPRAVSRMSMHPPSPVIYEQPPPRRIVVDQYGREYIEPVRATAIVREEPYDRPPPPRAVSRRPDPLDDEVHMYRPTSSGYAVPPRRVLTTQQPEYAYRDPEPRGTMPPPPLPQEYARPEPPREYIPRPASVRPVETVRYEPVPASYERVPPPPPAHLDDRPPRESQREAGYYRAASVHPTLSSSIPRYEVYDRRPPPPPAERPPEDRHFVPPPQPALGRAGSVRPVDPTPPTARYEYAPPPSSRGVVYAESVTATPVLGREVRAWSVMPDGEVPVRREFPPPPPPPPPPPPPPPPPPPPPPPQYIRPVQDRERDDDVIYIERGLAQGRDREREREREYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8G2</accession>
    <name>G0S8G2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiosulfate sulfurtransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0029770</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693432.1">
        <property type="nucleotide sequence ID" value="XM_006693369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8G2"/>
    <dbReference type="STRING" id="759272.G0S8G2"/>
    <dbReference type="GeneID" id="18257015"/>
    <dbReference type="KEGG" id="cthr:CTHT_0029770"/>
    <dbReference type="eggNOG" id="KOG1530">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089574_0_0_1"/>
    <dbReference type="OMA" id="EMAPRAY"/>
    <dbReference type="OrthoDB" id="566238at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01519">
        <property type="entry name" value="RHOD_HSP67B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE RDL2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086:SF10">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE_RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="124"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="226" mass="25262" checksum="3272DE8899DD7BD0" modified="2011-10-19" version="1">MSSSRLPPSLMKAAVQATPLTTSAAVTSRTGAVLRRSSAAAAAVSQRATLPPAARFSTISQRQSLEQLRQRFSSIPGISQRQWQQLQQRVYSTELETKQEEQAKEERPHKVYDFEAVKKLAEAPDRKTIIVDVREPNELQETGRIPGAINIPIKSAPDSFHISDEEFEDRYGYPRPPRDAEVVFYCRAGVRCKAAADLAKDAGWTNTGEYPGSWLEWFEKGGKVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8K0</accession>
    <name>G0S8K0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">VASt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0038360</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YSP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694256.1">
        <property type="nucleotide sequence ID" value="XM_006694193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8K0"/>
    <dbReference type="STRING" id="759272.G0S8K0"/>
    <dbReference type="GeneID" id="18257874"/>
    <dbReference type="KEGG" id="cthr:CTHT_0038360"/>
    <dbReference type="eggNOG" id="KOG1032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006864_0_0_1"/>
    <dbReference type="OMA" id="PSGNMIS"/>
    <dbReference type="OrthoDB" id="2162691at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140268">
        <property type="term" value="C:endoplasmic reticulum-plasma membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120015">
        <property type="term" value="F:sterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13220">
        <property type="entry name" value="PH-GRAM_GRAMDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051482">
        <property type="entry name" value="Cholesterol_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319:SF4">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="VASt" evidence="8">
        <location>
            <begin position="759"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="321"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="396"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="649"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="930"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1094"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="150"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="459"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="664"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="685"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="723"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="941"/>
            <end position="954"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS21960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1136" mass="120985" checksum="C5545310F080DD2B" modified="2011-10-19" version="1">MDSPSRLGKLLSNTISTKRRRSKTPMGEGRNTNSDAGSVGDRSHRASIGSRIAGSDSNSARSLPLHGDEASGSDYEAAQRRPTAISALPSSSPLASAPQATQAAQSPNPDSAASDPIQQLSRFPSIPDGPEILSVPAVDRSRTTVGSPRLEIKRSSSSSRLRDVFRPKKEPKDAKETLESKPETPRPLSVRTNFEPPKQPNLSPLDPPTPLIVNTPPTPTESKHPDRVFDSLSRPANVLLIGGGSMSSTTRRRAGSNAGPSKLSNITPAPPTPTPDNHTQANNNIINNPPATPANPAANFFSSMFTAVQNTANSLSTTLAQNKVKGSQPQAKDQVDAKNVDANEVQPSVTPGPSSESKEPAVKTLGLGDLSLSHLGIVDPPSATSPSPLATRFIQPESRARSDSAPAEPHSAIMETSGDNHASRPLSLNESADGFRTPPTASVHDGKSGIHRSGSNRSAHGHRGRRRGNSNATHVTTGTTIGAAITAATSSLANPAATPGPRLTGFAVANKKRNREFHNLFKSVPDDDYLIDDYSCALQREILAHGRLYISEGHLCFSSNILGWVTTLVLSFDEIVAVEKRSTALVFKNGLEISTLHSKHIFASFASRDTTYDLIIKIWKLGHPHLQSSLNGVRLAEPGGDRTEKIMDAESTSAPGSHESASGSDDESAEEDDDVYDEDEEDEGASPAAAAVSDGAAGQDADKGTRKVSGQLPTPAEKADDTPASAGGANSGSGSASSGDFPGPAAHAPTDCGDSATHYEKVLADETIPAPLGKVFSLLFGAESANWMGRWLTTEQKCTDLQMDDKRGLSEEVKSRTYSYIKPLNGSIGPKQTKCIVTEQIDAINFEKAVTISVSTQNPDVPSGNIFVVKTKYCLSWGENNGTRVQVNCAIEWSGKSWLKGAIERGANEGQTQYCKDLFAALRAAVSSRSRAGTMTNGRPGGKKRGGAGGRKNKPAPNALPSEADSATAKKQPSWGPLEPIRPFVSPIADAVKPILTGNVVYGLLVGLLVASWFGFGTLRSNTPSGPPGAYDPAAAAVYLYHHYPNYAQRVAAYDEMWRREESELWEWIEERVGLPERLGGEGPLNVGLGSMEARSVEERIREERMDERQLREAIRVTEERLGVLKGVVERRAGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9A9</accession>
    <name>G0S9A9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0045170</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694905.1">
        <property type="nucleotide sequence ID" value="XM_006694842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9A9"/>
    <dbReference type="GeneID" id="18258555"/>
    <dbReference type="KEGG" id="cthr:CTHT_0045170"/>
    <dbReference type="eggNOG" id="KOG2458">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028539_0_1_1"/>
    <dbReference type="OMA" id="HFAFWAW"/>
    <dbReference type="OrthoDB" id="202415at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF63">
        <property type="entry name" value="GLYCOSYL TRANSFERASE CAP10 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
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    </dbReference>
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        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="2">
        <location>
            <begin position="188"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS20020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="490" mass="55218" checksum="71057F4F9719B343" modified="2011-10-19" version="1">MYKEKPLPLFSPARRLPHSQHPPRRRLHLRHITFLLACILCICYFTLLSSSSSSASSRSPSHTHSETQSDTSTTPQKQQPSKARHDAGKGVPPSKRLPASLLNNLTLTEEECRATFPGLMKEIDDTVALGPFDVKDTGEFGPLQGRIKDGKLYILHTQRRKDLSQEMVNSRTATLHSLHRALLTSPSPIKDTIFTLNFLDQPFGTCLTYSRPADPSLHSPDPNARLFLMPHFSFWAWPLPFIGSMSRAMEAITRLEEGPEFGGEGGWQRKVSKAVWRGTTWFSSVTSPGMRAKLVQTTKDKPWADVEALDWDGKGKSARNGLKIEDFCRYKYVIHTEGVTYSGRFQYLQQCASVVLTPPIQWVQHTTHLVRPLFSSDLNLTPRWEPSERVKKAWPVRYGPEEANIVFVAPDWSDLGAVVEWLEQHPDLAEGIARRQRELFVGGGYFSPAAEACYWRALMNGWAKVARVEGSGLEDMEGTPFELWAMTNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9E5</accession>
    <name>G0S9E5_CHATD</name>
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        <recommendedName>
            <fullName evidence="2">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0045560</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694941.1">
        <property type="nucleotide sequence ID" value="XM_006694878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9E5"/>
    <dbReference type="STRING" id="759272.G0S9E5"/>
    <dbReference type="GeneID" id="18258594"/>
    <dbReference type="KEGG" id="cthr:CTHT_0045560"/>
    <dbReference type="eggNOG" id="ENOG502RXTA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014722_0_0_1"/>
    <dbReference type="OMA" id="VPQIANE"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF6">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013062228" description="DUF1996 domain-containing protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="2">
        <location>
            <begin position="36"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS20056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="350" mass="38549" checksum="0D26E3A8C8C10480" modified="2011-10-19" version="1">MFWLPLLTLPAAVQGQGFSTTMLRFGCSQIAIDRVDPLVEPGNVPSAHVHQIVGGNAFNASMPVTDISKLATCTSCTFDQDLSNYWTANVYFRARNGSYKRVPQMVNEAIGPANGGITVYYTAPGPNTVTAFKPGFRMFTGDVNRRTPTNLGRRVQSCFRCYTGPNFGGNIYAPCMDPQRDTEHFPTQPCPGGIRSSVIFPICWDGKNLDTPNHMDHVAHPIDGPAPFAVVDGKCPDSHPVKIPQVHYEIVWDTTAFNRKEDWPVDGSQPFVLSTGDPTGYGQHGDYVFGWKDNSLQHAMDNRCFGPTCRGLTTQGFDKANACTVKRLVNEDNDGWLDHLPGQEHLAHPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9K3</accession>
    <name>G0S9K3_CHATD</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0046190</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006694936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9K3"/>
    <dbReference type="STRING" id="759272.G0S9K3"/>
    <dbReference type="GeneID" id="18258657"/>
    <dbReference type="KEGG" id="cthr:CTHT_0046190"/>
    <dbReference type="eggNOG" id="ENOG502SG34">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038623_1_0_1"/>
    <dbReference type="OMA" id="PVSVYNW"/>
    <dbReference type="OrthoDB" id="4095124at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055449">
        <property type="entry name" value="Iec3-like_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032742">
        <property type="entry name" value="Iec3_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24244">
        <property type="entry name" value="Iec3-like_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14612">
        <property type="entry name" value="Ino80_Iec3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit 3 N-terminal" evidence="2">
        <location>
            <begin position="9"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="INO80 complex subunit 3-like middle region" evidence="3">
        <location>
            <begin position="103"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS20114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="405" mass="43205" checksum="EF50D77C3F986482" modified="2011-10-19" version="1">MAEDKPTYRSWKKKYRKMRIVFDQKMHEGEELHKLEQKALATVRRLAIQKDRLLDLLLDVNNSGQIPPEKRIDLSLDPPSDDEALALDIDRATTPPPGPRPAKSYKKLLREVPHLTWASAADHYPELVADIEAGRDSPADPLQGSAHPPSFLTADDIDNYLWEIDTRLSREEAAAASAANNNAPNGGTNIDATKPTKKKEPPLPTLAPLAHQDPTVPKDTARDFALRNPVSVYNWLRKNAPKTFLQDGEHQDGGAKEGKDHDGEGGSHGGSGTGSGRRGGKAGGSSECTPRGSGVRSSKRANAASRLAIAESFDDVDDEGYGTPGGVMTPVSTAGGGKGKRKRVVDDDPGYRPKGGSNRPAKKKKKVSDVGVGEQSTPTSKKPRKSAGAAAAAAGDGDSIRGADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9L5</accession>
    <name>G0S9L5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Complex ATPase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0046320</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2019" name="Nucleic Acids Res." volume="47" first="9400" last="9409">
            <title>Structure of the primed state of the ATPase domain of chromatin remodeling factor ISWI bound to the nucleosome.</title>
            <authorList>
                <person name="Chittori S."/>
                <person name="Hong J."/>
                <person name="Bai Y."/>
                <person name="Subramaniam S."/>
            </authorList>
            <dbReference type="PubMed" id="31402386"/>
            <dbReference type="DOI" id="10.1093/nar/gkz670"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (4.07 ANGSTROMS) OF 77-134 AND 167-722</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695011.1">
        <property type="nucleotide sequence ID" value="XM_006694948.1"/>
    </dbReference>
    <dbReference type="PDB" id="6PWF">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.07 A"/>
        <property type="chains" value="K=77-134, K=167-722"/>
    </dbReference>
    <dbReference type="PDBsum" id="6PWF"/>
    <dbReference type="AlphaFoldDB" id="G0S9L5"/>
    <dbReference type="EMDB" id="EMD-20507"/>
    <dbReference type="SMR" id="G0S9L5"/>
    <dbReference type="STRING" id="759272.G0S9L5"/>
    <dbReference type="GeneID" id="18258670"/>
    <dbReference type="KEGG" id="cthr:CTHT_0046320"/>
    <dbReference type="eggNOG" id="KOG0385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_0_2_1"/>
    <dbReference type="OMA" id="VHDYQFF"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031010">
        <property type="term" value="C:ISWI-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17997">
        <property type="entry name" value="DEXHc_SMARCA1_SMARCA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000036">
        <property type="entry name" value="Chromatin remodelling complex ATPase chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000082">
        <property type="entry name" value="ISWI chromatin remodeling complex ATPase ISW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000022">
        <property type="entry name" value="ISWI chromatin-remodeling complex ATPase CHR11 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1190:FF:000005">
        <property type="entry name" value="ISWI chromatin-remodeling complex ATPase ISW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000234">
        <property type="entry name" value="ISWI chromatin-remodeling complex ATPase ISW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.30:FF:000003">
        <property type="entry name" value="ISWI chromatin-remodeling complex ATPase ISW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1190">
        <property type="entry name" value="iswi atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.30">
        <property type="entry name" value="ISWI, HAND domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044754">
        <property type="entry name" value="Isw1/2_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015194">
        <property type="entry name" value="ISWI_HAND-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036306">
        <property type="entry name" value="ISWI_HAND-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015195">
        <property type="entry name" value="SLIDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF49">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09110">
        <property type="entry name" value="HAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09111">
        <property type="entry name" value="SLIDE"/>
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    </dbReference>
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        <property type="entry name" value="SNF2-rel_dom"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101224">
        <property type="entry name" value="HAND domain of the nucleosome remodeling ATPase ISWI"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="16" id="KW-0002">3D-structure</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="197"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="493"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="13">
        <location>
            <begin position="860"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="128"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1039"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1039"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1084"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1097"/>
            <end position="1129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS20126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="6PWF"/>
        </source>
    </evidence>
    <sequence length="1137" mass="129985" checksum="95B36033DBAC692A" modified="2011-10-19" version="1">MAPRSRLSGNDTDASMPDAPEVSQPEQRAEDMDIETPDYTDSDTNPNTTASSVAGEPVVDGRKKRSEANQLRRSIFGKKHDRLGENKEDDTLRRFRYLLGLTDLFRHFIETNPNPKIREIMAEIDRQNAEEAKKKKGGSRQGGATSERRRRTEAEEDAELLQDEKVGGSAETVFRESPPFIKGTMRDYQIAGLNWLISLHENGISGILADEMGLGKTLQTISFLGYLRHIQGITGPHLVAVPKSTLDNWKREFEKWTPDVNVLVLQGAKEERHQLINDRLIDEDFDVCITSYEMILREKAHLKKFAWEYIIIDEAHRIKNEESSLSQVIRMFSSRNRLLITGTPLQNNLHELWALLNFLLPDVFGDSDAFDQWFRGQDRDQDQVVQQLHRVLRPFLLRRVKSDVEKSLLPKKEINVYIGMSEMQVKWYKKILEKDIDAVNGAGGKRESKTRLLNIVMQLRKCCNHPYLFEGAEPGPPYTTDEHLIYNSGKMIVLDKLLKRLQSQGSRVLIFSQMSRLLDILEDYCVFRGYKYCRIDGGTAHEDRIAAIDEYNRPGSDKFIFLLTTRAGGLGINLTTADTVILYDSDWNPQADLQAMDRAHRIGQTKQVVVYRFVTDNAIEEKVLERAAQKLRLDQLVIQQGRAQIATKAAANKEELLSMIQHGAEKVFQTKGAFGLMAEKGANLDDDDIDAILKAGEERTRELNAKYEKLGIDDLQKFTSESAYEWNGEDFAARKKDIGFTWINPSKRERKEQIYSIDKYYKQALHSGGRAADSKPKAPRAPKQIPVHDYQFYPPRLRDLQDRETAWYRKEIGYKVPLPDGDDDNLSEREAERALDQAEIDNATPLTEEEKAEKEQLAQQGFGDWNRRDFQQFINGSSKYGRHNYEMIATEVDSKTPEEVEAYAKVFWQRYTEIADYMKYIKIIEDGEERMRKIEHQRKMLRKKLSQYRVPLQQLKINYSVSTTNKKVYTEEEDRFLLVLLDKYGIDSEGIYEKIRDEIRESPLFRFDWFFLSRTPTELARRCNTLLTTVVKEFEDADNAKDSKGGKDAKSNGVNGKVKREAEDEENDEDSVLGMAPAKKKSKTTTNGVKNKTLDNVKSTTASKANSASVSRASSVASSASNAAASKNKAAAKGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9M3</accession>
    <name>G0S9M3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclin-D1-binding protein 1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0046410</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695019.1">
        <property type="nucleotide sequence ID" value="XM_006694956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9M3"/>
    <dbReference type="STRING" id="759272.G0S9M3"/>
    <dbReference type="GeneID" id="18258679"/>
    <dbReference type="KEGG" id="cthr:CTHT_0046410"/>
    <dbReference type="eggNOG" id="ENOG502QZAU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040328_0_0_1"/>
    <dbReference type="OMA" id="WSKTWLK"/>
    <dbReference type="OrthoDB" id="4088536at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026907">
        <property type="entry name" value="GCIP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049317">
        <property type="entry name" value="GCIP-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492">
        <property type="entry name" value="CYCLIN D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492:SF1">
        <property type="entry name" value="CYCLIN-D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13324">
        <property type="entry name" value="GCIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-D1-binding protein 1-like N-terminal" evidence="2">
        <location>
            <begin position="67"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS20134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="386" mass="42567" checksum="3EC86E4288FF9CD2" modified="2011-10-19" version="1">MPSSSEAIEALNAAITNALILIDKLQTVVSQVTSQGSVENGRVDGRTTQQLSADSSSLDALTVAHDSASLIKAHATKISLLIINEPFTPTAITKVLQDLVAAPLPSLAAAVELCSPSQYTQAIQYDLAWRAGRVFKELSVLISQIPRDGKILPDAKKNAPPGAAEGRGSIATTGILWSACEDVIAFGKRGFSGILVKKVEELSETLKDVMEELKEWGEEAEEDNDDDNDGLADSDVEGDDEKDNSASNMQALLDDLMNSHSRIPRDDPHKIRERLEACLKKLRLTTLLYQATIKRRLKPLPRTPPTGSDIPVRLDEVLVLLKRIPEKFGNLAMAFYELDPVEIDRQMDECFLDAFAVSELLLKPWDKEKDEFTDWALRFQVEMKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9Q3</accession>
    <name>G0S9Q3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0046710</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695049.1">
        <property type="nucleotide sequence ID" value="XM_006694986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9Q3"/>
    <dbReference type="STRING" id="759272.G0S9Q3"/>
    <dbReference type="GeneID" id="18258709"/>
    <dbReference type="KEGG" id="cthr:CTHT_0046710"/>
    <dbReference type="eggNOG" id="ENOG502SKC8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005594_0_0_1"/>
    <dbReference type="OMA" id="IYCWRNG"/>
    <dbReference type="OrthoDB" id="3915838at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01833">
        <property type="entry name" value="XynB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051532">
        <property type="entry name" value="Ester_Hydrolysis_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383:SF31">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383">
        <property type="entry name" value="THIOESTERASE 1/PROTEASE 1/LYSOPHOSPHOLIPASE L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408929" description="SGNH hydrolase-type esterase domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="4">
        <location>
            <begin position="71"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="881"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="881"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="909"/>
            <end position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS20164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="919" mass="100897" checksum="6A86DAF8C229DAEF" modified="2011-10-19" version="1">MRISSNSLAYAGCLLLFCIHSLAAHPAIIVDHSSSISPGLEPLTIRSDDTPNVNNSVTTSGHPFYLRILPLGASITWGTGSTTGNGYRKPLRDQLRFDGWSVNMVGSRAGGNMNDRDVEGWPGYRIDQVHSRARLVVPRYKPNVVLINAGTNDATQGYHVASAGDRMRDLVSYIFDTVPNVTVLLSTLLPNTASPMHVLLINRQLRDLAKEFTSNGRHLVLVDFADGFLTMEDIPDGTHPNDAGYGKMAAKWYQGIKQAYRNGWLASPDQDVDFSDAKAGEKTCDKRYGSGNLDARSPMQVLKALSPRIVDDGRYIHNSQAMGVIHTGTYDGDDMVWFAQLVNNGAGRGGELDDLVFSEGQGEIWYRENLGDGKFGEKTQIPSLKAIPCPQRAIRWGDVNNDGLDDFIFIDQSGNMYVAINDGGKPPVFRNVGLYKTAPSGYSLENVRLGDIDGDGRLDYCVLAGNGDIYCWRNGGVGDMAASWQDIGDGKPVFKGKGMGNIDGVRLVDLNGDFRADWLWLDDTGKVTAYINQRGSNKGLIPVWDPAGVTHAGMGETCARSQIRFAKIYGSGRADYVYVKCTRPSPNHCDYQILAWRNTGGGGAHQKGDGARWCDMTGTGNDDYVFIDHTSKLTIFRNRNAPPNTDYSGWVDKGVVLDLSGTSRGAIHLGDWDGDGKCDVIITDKKTGSLDVYFTRWDQTTDMFSFSPRTRVVSSGCTQGWGVGPTDLGIRFADIDGDRRVDYLCLEPNGRVTGWLNKPSGLQWQSQIKFSEKRDRAEHRFADVNGDGRADFLWVDRFTGETEVWYNMGPRQISGSSFWWEPKGKLYQGASMGENLHFVNLGGQDRADMVVVEPKTGLGWVWFNGCPYGGDDGPIRDPHLPVLPGEKDEWGMPGKGDDGGGRNVGDVGDAGRDDVERPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9W9</accession>
    <name>G0S9W9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">argininosuccinate lyase</fullName>
            <ecNumber evidence="4">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0047460</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="4"/>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695115.1">
        <property type="nucleotide sequence ID" value="XM_006695052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9W9"/>
    <dbReference type="STRING" id="759272.G0S9W9"/>
    <dbReference type="GeneID" id="18258784"/>
    <dbReference type="KEGG" id="cthr:CTHT_0047460"/>
    <dbReference type="eggNOG" id="KOG1316">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027272_2_1_1"/>
    <dbReference type="OMA" id="DFAIEFC"/>
    <dbReference type="OrthoDB" id="2561043at2759"/>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000002">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000001">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000015">
        <property type="entry name" value="argininosuccinate lyase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814:SF1">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="6">
        <location>
            <begin position="17"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Argininosuccinate lyase C-terminal" evidence="7">
        <location>
            <begin position="375"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS20230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="471" mass="51666" checksum="87133E4E3A133C5E" modified="2011-10-19" version="1">MASNNAKPLLWGGRFSGAIAGAIDELMFQFNESLSFDKVLYKADIRGSITWAKALRKLDILTDEELDTIVTGLQAVEKEWEEGKFVIHTSSDEDIHTANERRLGELIGATAGKLHTGRSRNEQVGVDMRLWAGEQLDQLSVILKDVLRVFAERAKEALPVLMPGYTHLQRAQPVRFSHWLLSHATFLKGDLQRLEGVQERMSACPLGVGALAGNPFGIDREFMAKDLGFRSVHPNSLCAVADRDFVVEILQWASLTMAHLSRLAEDLILFSSAEFGFVQVADAYSTGSSLMPQKKNPDSLELIRGKAGRVMGHASGFLASLKSLPTSYNKDLQESVEPMIDTINSVSTCLRITQGVLATLKINGDKMRAALTDDMLATDVADYLVRKGVPFRQTHHIAGAIVRKAEEVGVSISALPLETFKEISPLFEEDISEVFDFEKSVEKRCTPGGTSSSSVLAQIAALEAFVSGQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9Z0</accession>
    <name>G0S9Z0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Yippee domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0040380</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the yippee family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694447.1">
        <property type="nucleotide sequence ID" value="XM_006694384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9Z0"/>
    <dbReference type="STRING" id="759272.G0S9Z0"/>
    <dbReference type="GeneID" id="18258076"/>
    <dbReference type="KEGG" id="cthr:CTHT_0040380"/>
    <dbReference type="eggNOG" id="KOG3399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_959774_0_0_1"/>
    <dbReference type="OrthoDB" id="6407410at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Yippee" evidence="6">
        <location>
            <begin position="119"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="103"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS19562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="290" mass="31985" checksum="96D9C6E1AF911FA8" modified="2011-10-19" version="1">MLDVNIASLPAPFSSPALPSASSDISIKIPTCGKLFRYPFVLRLLTFLPIFIIVFLSPCPIGFQLPGWQPIFPRLSADPGIFWPPIIAKSFVGRHGRAYLVAPPPPSVKRSQISSRSSSSGNTGSNSDGRGSVDSSSSSSNAFNQGYQSVDRNLVNITVGKHEERQLVTGMHTVADISCAGCGTVVGWKYIDAQDERQKYKVGKFILETRRVIGFHSWEDIEESNEIMLPHEKKSGHNGEDDSDSIIVFDSDDEDELEDIFTAVWDPVVVAEHRRSRTASMSRENSGMFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2023-02-22" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>G0SA21</accession>
    <name>G0SA21_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0040720</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694478.1">
        <property type="nucleotide sequence ID" value="XM_006694415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SA21"/>
    <dbReference type="GeneID" id="18258110"/>
    <dbReference type="KEGG" id="cthr:CTHT_0040720"/>
    <dbReference type="HOGENOM" id="CLU_2196653_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS19593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="108" mass="11966" checksum="21239A5E93533A7F" modified="2011-10-19" version="1">MPIIVRILRHPPELLDRHTTAAYDTVHLAARVGIKRAILDRVIRAALQGDELPMRAAAAAQQEHEACGCHLVKNLKEWLTIVYDLVADGINMGLNRGVFGNSLRLGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0SA58</accession>
    <name>G0SA58_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Terpene synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0041090</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694515.1">
        <property type="nucleotide sequence ID" value="XM_006694452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SA58"/>
    <dbReference type="SMR" id="G0SA58"/>
    <dbReference type="GeneID" id="18258147"/>
    <dbReference type="KEGG" id="cthr:CTHT_0041090"/>
    <dbReference type="eggNOG" id="ENOG502S93P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_504313_0_0_1"/>
    <dbReference type="OrthoDB" id="9970095at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1240">
        <property type="entry name" value="DOPA-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023389">
        <property type="entry name" value="DOPA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014980">
        <property type="entry name" value="DOPA_dioxygen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36423">
        <property type="entry name" value="AFR070WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36423:SF2">
        <property type="entry name" value="AFR070WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08883">
        <property type="entry name" value="DOPA_dioxygen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143410">
        <property type="entry name" value="DOPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="540" mass="61410" checksum="C35D0868F1F926B9" modified="2011-10-19" version="1">MEKTRVAGADCWAMRLLGSDLAPRLRGQQFRIPDLWPLFETWKRGVNREYMRVKIVVDAQLEGLIVGNEKALAEAKRAEPGLCAAAWFPDVTYDALETAALYSIWLILWDDAIDRLGPAAGDADNVALAAEEYCWASLRFVRHHLWLDEGDHGIEEPAAPTKICDSFRDVAVRLRRYVEDVKERRRLFEHLAEFMEGVMAEYRCKMSGQAQSLDEFYSVRLKTVSVKPLLELSRLLNRISVPQDVLESSELDNMALDVAKIGMIVNDLFSLKKELKDETVTNMVTATMSAHNLDLRGAVAHAIREMQKCIQRFDANSAALQRKAVQDHGEAIEGELKRLIQAYQAISLEFNWPSPLAGYESAPPLPDEKNEDGKSLKNPQTGALSPAYERFIDPLDNGRRGGFDVHVYYFQNNPEQTKYARELWERIRREFPELRIYTFWDRPIGPHPVAMFEVNLFTPAQFGAFIPWLAIWRGPLSVLVHPNTTEEDISIAERELKNHTSRAIWMGERLPLDVARFRMFAQAQAHQQAQSAASNVQASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBK2</accession>
    <name>G0SBK2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="12">tRNA-dihydrouridine synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0053870</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="9">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695723.1">
        <property type="nucleotide sequence ID" value="XM_006695660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBK2"/>
    <dbReference type="STRING" id="759272.G0SBK2"/>
    <dbReference type="GeneID" id="18259425"/>
    <dbReference type="KEGG" id="cthr:CTHT_0053870"/>
    <dbReference type="eggNOG" id="KOG2334">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013299_3_2_1"/>
    <dbReference type="OMA" id="GPIRTNS"/>
    <dbReference type="OrthoDB" id="10262250at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052582">
        <property type="entry name" value="tRNA-DUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="11">
        <location>
            <begin position="79"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="427"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="466"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS18778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="484" mass="51953" checksum="47EA5366C088E354" modified="2011-10-19" version="1">MTTGTHDSAPAATAAIVVATGTAAATAAIPTTNTATATTSTSSNGTSDGPTPADVPSPVALPRVPIPPRGVDYRGKVVLAPMVRSGELPMRLMALHYGADLVWGPETVDRSLIGAKRRINPRTNMIEYTRLPSHTHSPAAQYEGNQESVIYRLDPVREAGKLVFQLGTADPNLAVEAARFVAPDVAGIDVNAGCPKPFSLSGGMGAALLRDPDRLVAILEALTREIPPQFGIGVSVKIRLLETAEKTEALVRRLVRTGITGLTVHCRTTPMRPREPAIRGQLRMIADVCREAGVACVVNGDVASRDHGMKLCTEFGTDGAMIATAAEKNPSCFRPADPESGTTPLAPWQELADKYIRFALEVENKIANTKFSLTQLIPGKAKEYKMVQACKSYTEIVKVLGLEGELGEVAREQDRLQALGEFEILKAKKKNQQQQQQQESKKRKREDEEAEEGRRKDERAVEANGAPTEPTAPTPESAVASISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G0SC18</accession>
    <name>G0SC18_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">26S proteasome regulatory subunit rpn11-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0055580</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695889.1">
        <property type="nucleotide sequence ID" value="XM_006695826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SC18"/>
    <dbReference type="STRING" id="759272.G0SC18"/>
    <dbReference type="MEROPS" id="M67.A11"/>
    <dbReference type="GeneID" id="18259596"/>
    <dbReference type="KEGG" id="cthr:CTHT_0055580"/>
    <dbReference type="eggNOG" id="KOG1555">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052991_0_0_1"/>
    <dbReference type="OMA" id="KTGRHEM"/>
    <dbReference type="OrthoDB" id="605656at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000001">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056263">
        <property type="entry name" value="RPN11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23594">
        <property type="entry name" value="RPN11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6 11" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="10">
        <location>
            <begin position="34"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="234"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS18944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="337" mass="37776" checksum="9311AE93EB4CEC1F" modified="2011-10-19" version="1">MERFRSLLSGGNLGLGGAAPGTDNTNLIDNSETVHISSLALLKMLRHGRAGVPMEVMGLMLGEFVDDFTVKVVDVFAMPQSGTGVSVEAVDPVFQMKMMDMLRQTGRPESVVGWYHSHPGFGCWLSSVDINTQQSFEQLTPRAVAVVIDPIQSVKGKVVIDAFRLINPQSLMMGQEPRQSTSNLGHLNKPSIQALIHGLNRHYYSIAINYRKTALEENMLMNLHKHEWTEALQMEDFRAEAQRTKERLQRLVSLAEGYEKRVKEETELTKEQLKTRYVGKLDPKKHLQDVGQQLIEDNIVAVSRQMIDKEATMAKKEVPAGANGQFAEDEMEVDEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCK9</accession>
    <name>G0SCK9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0057600</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable lipid hydrolase.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696080.1">
        <property type="nucleotide sequence ID" value="XM_006696017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCK9"/>
    <dbReference type="STRING" id="759272.G0SCK9"/>
    <dbReference type="GeneID" id="18259798"/>
    <dbReference type="KEGG" id="cthr:CTHT_0057600"/>
    <dbReference type="eggNOG" id="KOG2214">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009031_5_0_1"/>
    <dbReference type="OMA" id="SIVPWPH"/>
    <dbReference type="OrthoDB" id="10049244at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07229">
        <property type="entry name" value="Pat_TGL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF44">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="8">
        <location>
            <begin position="250"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="606"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="634"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS19135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="645" mass="73786" checksum="0D3C40AA25921CDC" modified="2011-10-19" version="1">MATSIWPNCFSAAVVANGMVNLYRWFIEALPGKLKARVKTASQYVAAFVNVLVYAVVHWTMRYWRKFRGPSPVRYWLGRMHNATTFEEWEEAAQRVDALLDLNIWRQEDKHPEYDYRLIHQRMAAMKEAHDKNDLPTLFNLLRSGLIRNLGNITSKELYNGAFAGTKDLIEDYIGQFLLFIDDIVEMNKGPYRVLKRGRVPFASLEDSDTPESSAENKPRDTGELKVDIPPTEKVNLFHGWRQTYGRTALVLQGGSLFGFCHLGVVKALFLRGLLPRVIVGTATGAIMAALVAVHSDDDLLQVLKGESIDLSAFKRKNAEPSGDGWLSTTWRRLKRYVRKGHFLDSEVLEKCVRDNIGDVTFQEAYERSKRVLNITVVTDEQDRIPRVLNYLNAPNVVIWSAAVASNVSSGRIYGPNRGPRILCKDKYGRVVPWRPMLNSPFFHYLKGTYQGRNAPLQRMAELFGVNHFVISQARPYLLPFLRPEVHGPQIEKRQPWPMRAISFALKLGVLEMRYRLRQLDRLGVMPLPVRRFLVDEDVPGDSLTLVPSIELKEFVGLLGRPTAESINDWILKGERSVWPSMTALEVRLAIEMKLDMAYERVRKEYSREVNKSRRKDKKGSDDDGLSSKRKKKGSGDDKKKKGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCM9</accession>
    <name>G0SCM9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0057800</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696100.1">
        <property type="nucleotide sequence ID" value="XM_006696037.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0SCM9"/>
    <dbReference type="GeneID" id="18259818"/>
    <dbReference type="KEGG" id="cthr:CTHT_0057800"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrial inner membrane"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:oligopeptide export from mitochondrion"/>
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    </dbReference>
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        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
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        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
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        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="3"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="ABC1_TM_dom"/>
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        <property type="entry name" value="ABC1_TM_sf"/>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
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        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF11">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_membrane"/>
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    </dbReference>
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        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="2"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="299"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="754"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="797"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="873"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="902"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="73"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="398"/>
            <end position="690"/>
        </location>
    </feature>
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        <location>
            <begin position="758"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1081"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="467"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="22"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
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            <begin position="467"/>
            <end position="477"/>
        </location>
    </feature>
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            <begin position="478"/>
            <end position="494"/>
        </location>
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            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS19155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1323" mass="145589" checksum="817FE03A66F621DF" modified="2011-10-19" version="1">MADEKVKDTGGSQDVALTIDKSQNEKACHEDNAGQDERDRSKSAQGQPEREATFQDYLRVFTYANKWDFALMAAGVISSIGAGVTMPLMNVVFGKLMGEFTSLGTPNGPPEDVFRDTIDRMSLYMMGLFLARFCLNYINKFSFRLIGIRMSAGIRMHYLSSLFSQTIHVLDSMPPGAAASTITSTSNTLQLGISEKLGTCLEYLATVIAALVVSFTFSWSVTLVTCSVVLFISLVTSIFLPFIIKGQTRMSKADNRATAVATESFSAIRMVASCGAENRMSQRFSEWVKQAKQANIFSAPFLGGQFGSIFFAVYGTFALTFWFGVKQKVEGHIDGIVEIMICVLSVTMIVPSMERISTSLVAVTKAMVAAAEFFAVIDAPKPKMGTLKEPDVTADQDIIFEDVHFAYPSRPSKKVLDGLNLRIRANKNTAIVGPSGSGKSTIVGLIEGWYSLREQVVIAKAVQKDKKKEKKGKKEKEEDTDEDILAPIDAEEETGPPVELKGRISTCGKTLEEIDMKWWRSQIGLVQQEPFLFNDTIFNNVAAGLIGTQWENEPEEIKRKLVKEACVESFADEFIDRLPDGYDTIVGDSGAKLSGGQRQRIAIARSIIKKPKILILDEATSAIDVRGERIVQAALERASKGRTTITIAHRLSTIKNADCICVLKAGRVVEEGTHESLLANEGGVYSGLVHAQKLSLGEETGEELLEEEDIGAVLAREKSAAKIEGESFKEETTWKDRNLINGFGKLLYEQRSRFPLYIIALLGSMGAAAAVPLLAYLLSRVVGTFQLQDDDKLMDEITFWCKMWAVLAAGVGTSYGLTSFVCTHLESHIVAVYKKEYFESILFQPTAYFDKDDNAIGQLTSRLSSDPQALKELLGINLMMMIIGILGMVGALIISFVYGWKLALVALCVTVPIGIVSGFFRVRYEIQFNAMNQAVFQESSKFGAEAIGAFRTVSSLVMEQSICDRYQRLLHGHVVAAFKKARWATLIISFADSSNIGCQALIFWYGSRLLLSGEYDVVAFMVTYMAMIQGAESCGTWLSFGPNAAQAQAAANRILQARETRIKDDISRSEQIPDTEGGVKIELKDVHFKYPTRDVSIFKGLNITIEKGQFAALVGASGSGKTSIISLLERFYDPIKGEILFNGKNIQAINVYEHRKLLSLVAQEPSLFHGTIRENILLGVDPDSVTEEQLYQACRDANIHDFIVSLPEGYNTNIGSRGVSLSGGQKQRLAIARALIRNPRVLLLDEATSALDSESEKLVQAAFERAAKGRTMVAVAHRLATIQNADIIYVLGEGKVIEKGTHAELLKQKGVYWHMCHNQALDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCU1</accession>
    <name>G0SCU1_CHATD</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0058420</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EGS19217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_006696099.1"/>
    </dbReference>
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    <dbReference type="STRING" id="759272.G0SCU1"/>
    <dbReference type="GeneID" id="18259880"/>
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    <dbReference type="eggNOG" id="ENOG502STJP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OMA" id="NTPPCAQ"/>
    <dbReference type="OrthoDB" id="3538943at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="106"/>
        </location>
    </feature>
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        <location>
            <begin position="119"/>
            <end position="179"/>
        </location>
    </feature>
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        <location>
            <begin position="229"/>
            <end position="389"/>
        </location>
    </feature>
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        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
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        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="499" mass="54876" checksum="2EA021246971E505" modified="2011-10-19" version="1">MAGLPVPCDWSPDLLLSLSRGHRVSRRWIQVPKDQQKLLERSDAWDVRGTPKVPAQVLEELRRSHAKEIKEYEIQNNELVPEQEGSPSRLAPSAVEGFQSQPSTPGYEFATQIDAAAPDGQLGAHDADDDSEDEPSDQPLRSCMTLSSEHLHPQSRFKGQDLDPDAPSPSESLPEAPVARPLSNIISQVPLPSNIPHSSLASEASLDIEVPKAATDTLEPVNLEATSVHAADPTPAPLPMSATGRPQFTSTPPSAQIIPSTIPTEPTQTKRNRLMKPPAALFNSRDDRSNSRDISRLGPGQELSGIARSPNPELTSSALPTSPSRRAMHMQPSAAFAPGRKRAPIAAEIIPQESSRTGDLPVVRPEASPKSSDDSNKPSPNKPPSQAPYTAFKVAYPDFRGTETDFVRAIIIISKLQRSKELPEFLYDDFVRVFCSDYLDYISAVDGKETPLPTIKWYNENVSEPRYTKKILNKQNIHEVKEEYPNQRSAQATPNRRCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>G0SD43</accession>
    <name>G0SD43_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Glucanase</fullName>
            <ecNumber evidence="12">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0050750</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2012" name="Acta Crystallogr. D" volume="68" first="875" last="882">
            <title>Structure of the catalytic core module of the Chaetomium thermophilum family GH6 cellobiohydrolase Cel6A.</title>
            <authorList>
                <person name="Thompson A.J."/>
                <person name="Heu T."/>
                <person name="Shaghasi T."/>
                <person name="Benyamino R."/>
                <person name="Jones A."/>
                <person name="Friis E.P."/>
                <person name="Wilson K.S."/>
                <person name="Davies G.J."/>
            </authorList>
            <dbReference type="PubMed" id="22868752"/>
            <dbReference type="DOI" id="10.1107/s0907444912016496"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 113-476</scope>
        <scope>DISULFIDE BONDS</scope>
    </reference>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyl hydrolase family 6.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="12"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695418.1">
        <property type="nucleotide sequence ID" value="XM_006695355.1"/>
    </dbReference>
    <dbReference type="PDB" id="4A05">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.90 A"/>
        <property type="chains" value="A=113-476"/>
    </dbReference>
    <dbReference type="PDBsum" id="4A05"/>
    <dbReference type="AlphaFoldDB" id="G0SD43"/>
    <dbReference type="SMR" id="G0SD43"/>
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        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.44 ANGSTROMS) IN COMPLEX WITH [2FE-2S] CLUSTER</scope>
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            <name>[2Fe-2S] cluster</name>
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        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
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        <property type="method" value="EM"/>
        <property type="resolution" value="2.44 A"/>
        <property type="chains" value="H=1-318"/>
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    <dbReference type="AlphaFoldDB" id="G0SDM6"/>
    <dbReference type="EMDB" id="EMD-14791"/>
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    <dbReference type="KEGG" id="cthr:CTHT_0052320"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054362_1_0_1"/>
    <dbReference type="OMA" id="ERTMHYL"/>
    <dbReference type="OrthoDB" id="10254187at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098796">
        <property type="term" value="C:membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
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        <property type="entry name" value="Thioredoxin-like_sf"/>
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    <dbReference type="NCBIfam" id="NF005725">
        <property type="entry name" value="PRK07539.1-5"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10371:SF3">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10371">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE FLAVOPROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01257">
        <property type="entry name" value="2Fe-2S_thioredx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01099">
        <property type="entry name" value="COMPLEX1_24K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2 12 13" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="12 13 14" id="KW-0002">3D-structure</keyword>
    <keyword evidence="5 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="6 12 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="277"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="290"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12 13 14">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 13 14">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 13 14">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 13 14">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 13 14">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 13 14">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 13 14">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS18627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="7ZM7"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="7ZMB"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="7ZMG"/>
        </source>
    </evidence>
    <sequence length="318" mass="34964" checksum="FADFFD394F92888E" modified="2011-10-19" version="1">MRRRQLSLQAGPFAEPKANQARKSSSNGERSSTTSQDHDPVRPGIDAAIARSLDTTAAMASKLTPLLMRTVARMGSRAMWAMVPAPARTLSTSAMRHSDTLMVHRNTPENNPDIPFKFTPENEKIIEQILKRYPPQYKKAAVMPLLDLGQRQHGFCSISVMNEVARILEMPPMRVYEVASFYTMYNRTPVGKFHVQACTTTPCQLGGCGSDAIVKAIKEHLGINQGETTPDGLFTFIEVECLGACVNAPMVQINDDYYEDLTPETIKQVLTALKESVNDVSKAPKPGPQSGRQSCENSAGLTSLTSEPWGPEKTRPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDN8</accession>
    <name>G0SDN8_CHATD</name>
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        <recommendedName>
            <fullName evidence="3">DUF6536 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0052440</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695584.1">
        <property type="nucleotide sequence ID" value="XM_006695521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDN8"/>
    <dbReference type="STRING" id="759272.G0SDN8"/>
    <dbReference type="GeneID" id="18259282"/>
    <dbReference type="KEGG" id="cthr:CTHT_0052440"/>
    <dbReference type="eggNOG" id="ENOG502RYAY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010112_3_0_1"/>
    <dbReference type="OMA" id="NFMRGET"/>
    <dbReference type="OrthoDB" id="5429634at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046623">
        <property type="entry name" value="DUF6536"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395:SF1">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20163">
        <property type="entry name" value="DUF6536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="549"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="636"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="679"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="764"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="804"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6536" evidence="3">
        <location>
            <begin position="284"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS18639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="925" mass="100869" checksum="7958A02B62A5FE3F" modified="2011-10-19" version="1">MGRRHTATPGMQMERLHRVNSEQPPDQEMHERGRDRDSVQWPFQSITTTDSTELPSSISTVVDRLPQRGSTRSSRHQQQDQQDQFRQSLHSQYLHPQWQQSLRFGRTEVSSLSSNPRFHIGEAGEIAENGEYNTLASDIVPDYIINYLRGETPESIAQRRNCQTAVTTIQADHLAEQEPKSQSQPQQEGFQVADAMVENPYADRHRSRVADFVGFDVGSTQTGHEYGGEVLAGADSGRDGDETELFLRRDQRGAQWGRQQKIIEKEKHLDWGRGSSKRKLSQGWRAGVVVIVATMFVLLIAAFMCLAVAISDEGRSDGRWAIFQGSCEAAARFDWGLHAIINVVAMIFLSGANYVFQALTSPTRDEVNAAHVRGRWLDIGIPSFRNLKYIGRRRAAVASVVLSVAFVTHMIYNAVIYVSRTAPNFTAALVSTQFVEGAPFSNASAFNAAGLSRLELLELQRESMANKLIHLAPSTCIKDFSGPFTTSYSTVLFVTFSEPMPPVLNQTTRGVNFTSINDFIPPELSLLFCLVKPASDLTSTCEININPHLLAVVALLKAIAFVAITSMIFVYSFRPLATLGDTIASFLQDPDPTTQGTCLLSKADVCSGGWPLIALQARYWVPHTHFWLRSVSLPRWLASIAIWIPCVGLAAVGLIITLTSNPGSRLSDTFSGAATSSPYNLVLGLSSVIPVAAAAFLVSLPHLLLGMLYLATNALLTTFYFSHESSLFATTPPRPLRVSAAVPEGAQTPSGLLRLTLPRRVSSVLMVVFMVMGFLLSRGFWAIGVRFVDPNIMDNSNSVTTRSAIGLSPAPLLTLLTFLLILAFTILGFGLRRAPSVGAGGNPMALAGGSCSAVISARCHPLARERDGLWLKPVMWGVVREGNLPSSGTATRNTSGSWGWGGVAVSHCGFTAGRAGVVEPGREYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDR4</accession>
    <name>G0SDR4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0052710</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695610.1">
        <property type="nucleotide sequence ID" value="XM_006695547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDR4"/>
    <dbReference type="STRING" id="759272.G0SDR4"/>
    <dbReference type="GeneID" id="18259309"/>
    <dbReference type="KEGG" id="cthr:CTHT_0052710"/>
    <dbReference type="eggNOG" id="KOG0201">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007561_0_1_1"/>
    <dbReference type="OMA" id="VWMVTEY"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000670">
        <property type="entry name" value="Serine/threonin protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="38"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="371"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="435"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="493"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="585"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="666"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="524"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="601"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS18665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="828" mass="91667" checksum="05EBC6679C7843FC" modified="2011-10-19" version="1">MASDQQLTTKQKAIQEARTVQALVEKECADAGRDPPPYDLAELIGKGSFGRVYKAKSRETGKLVAIKIISIDEGDSYAPGQADTFNDILKEVNTLKRLNEGGAKNINLVIDSLLIGPTIWIVTEYCAGGSVATLMRPTNGLQEKYIIPILREVAEAIYWVHKQGVIHRDIKCANVLIGEAGQVQLCDFGVAGIIETKFDKRSTVTGSLQWMAPELFDSTVSYGSEVDIWAFGSMAYEMATGLPPNARPIVDITEFGAYLKQHCPRLTGDQYSEGLKDLIAFCLVDDPRQRPPIEQIQRHHYIYNTEVAYPTSSLAELVEWYKAWELQGGSRRSLFTAGGAQAPLTDRSSSGSDDGWNFDIINEETDLISPTEGIRDHDIPLEAPLSPKQDRWRARRRRPPPNIRPLKVPLEKVFDPNTITSYTEAARAFYGKGLKQELQKPASSPPPQEKSSSTDLPLRDKSDQQSVRESLIDLDASLEGMDSCEFSSEFDMTTIKPIRRPDPPPIDTGPAEGDRGRTLDWTFPSATPSSEPQSSLNHNDNSHHGIFSPVDSVQVFTPLPKPAFSTAQSPPAAENRFSAVSLIDLDDATPDPDPSAYRFSAANTNYSRPSTSHSEVPSTISSDRAETPFGFDLPLHQHNDYSYEHPSQPTREREPSIYIDADVGVGESLNGGEEKHLSPENSISISSEPPPTPERSPLRAVRMMQQQQREHILQSRQQRMRHRELQLQLSPEYKLQRGGIRTGSVGSSMNHGIQDKELIIPLQMPAPKSLSQLPIPTPPSPLVMQGMSSPEKTKEELNRLIASFCGHLQLTGHVVESLPVRVQKDLMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0SE07</accession>
    <name>G0SE07_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Import receptor subunit-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0061990</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="12 13 14" key="2">
        <citation type="journal article" date="2025" name="Proc. Natl. Acad. Sci. U.S.A." volume="122" first="e2507279122" last="e2507279122">
            <title>Structures of &amp;lt;i&amp;gt;Chaetomium thermophilum&amp;lt;/i&amp;gt; TOM complexes with bound preproteins.</title>
            <authorList>
                <person name="Agip A.A."/>
                <person name="Ornelas P."/>
                <person name="Yang T.J."/>
                <person name="Uboldi E."/>
                <person name="Hader S."/>
                <person name="McDowell M.A."/>
                <person name="Kuhlbrandt W."/>
            </authorList>
            <dbReference type="PubMed" id="40674418"/>
            <dbReference type="DOI" id="10.1073/pnas.2507279122"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom7 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696515.1">
        <property type="nucleotide sequence ID" value="XM_006696452.1"/>
    </dbReference>
    <dbReference type="PDB" id="9I6B">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="I/J=1-71"/>
    </dbReference>
    <dbReference type="PDB" id="9I7P">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="I/J=1-71"/>
    </dbReference>
    <dbReference type="PDB" id="9I7S">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="I/J=1-71"/>
    </dbReference>
    <dbReference type="PDB" id="9I7T">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.80 A"/>
        <property type="chains" value="I/J=1-71"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SE07"/>
    <dbReference type="EMDB" id="EMD-52652"/>
    <dbReference type="EMDB" id="EMD-52658"/>
    <dbReference type="EMDB" id="EMD-52660"/>
    <dbReference type="EMDB" id="EMD-52661"/>
    <dbReference type="STRING" id="759272.G0SE07"/>
    <dbReference type="GeneID" id="18260237"/>
    <dbReference type="KEGG" id="cthr:CTHT_0061990"/>
    <dbReference type="eggNOG" id="KOG4449">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_194715_0_0_1"/>
    <dbReference type="OMA" id="IMRVFEW"/>
    <dbReference type="OrthoDB" id="284357at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012621">
        <property type="entry name" value="Tom7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34944">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34944:SF2">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08038">
        <property type="entry name" value="Tom7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="12 13 14" id="KW-0002">3D-structure</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS18184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="9I6B"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="9I7P"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="9I7S"/>
        </source>
    </evidence>
    <sequence length="71" mass="8098" checksum="BC2E9B7B89357FF8" modified="2011-10-19" version="1">MLALSEESKVRRGPSLRTIRLGADSKQERISKLIEISRVVIHYGYLPMILYLGYTRSEPKPSIIRLLSPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEA5</accession>
    <name>G0SEA5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0063060</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696613.1">
        <property type="nucleotide sequence ID" value="XM_006696550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEA5"/>
    <dbReference type="STRING" id="759272.G0SEA5"/>
    <dbReference type="GeneID" id="18260344"/>
    <dbReference type="KEGG" id="cthr:CTHT_0063060"/>
    <dbReference type="eggNOG" id="ENOG502S1UN">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="ELMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37332">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
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        </location>
    </feature>
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            <begin position="7"/>
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        </location>
    </feature>
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            <begin position="184"/>
            <end position="201"/>
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    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="546" mass="57895" checksum="E3DBBE447FE5AD17" modified="2011-10-19" version="1">MQAAAPFLSGLFSGGSNNSTNGNNTTTAGRDRESREDKDTTASSSTVSTVSTCPSTSTKSTHESAPSSIPSSPTSRSPVRSRPPTSSDQDNFSHLNRIASTTTTNTVLTSPPGRPLNPLSALSSLTSLISRDRERDKDRKTFNRKPSLHFTRRRASSRSSSPSSPVTQAPGQPPLPSIQLAGDGQTTSVSGPESIQQQQGGTAPAEGLSKMLSRGAVTPISGYPIQGPATAMLMSSATAQQNELAVLHQHIQETVNKRISTLDYLRKAHEGHIYWFNTLLFDKPDLQRMPYFDSRKLARRATNYLLLGISLPAVIDLNSNHPVDFLRSLNHLLTEFDSFQQNHSETGQPPSTLARARLPQMFRRAAAPVSKGRRSSSAAGRDTGDSLSGGMSALELVDSNTGTVASGTSASATSSATGTAPGSAGPTAETAGVMAFSSPAAHDSLDLLPGEEYTHLLTPTLPFDPDFFETFATLCDVLIDTYNRLLALVPTPQACSGPVGELFAKADSKVRKLLVQGVIKEFEETSRAGARAEVAGIGRVVLSGLM</sequence>
</entry>
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    <accession>G0SEE5</accession>
    <name>G0SEE5_CHATD</name>
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        </recommendedName>
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        </alternativeName>
    </protein>
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        <name evidence="5" type="ORF">CTHT_0063460</name>
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        </lineage>
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        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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        <text evidence="2">Common component of the spliceosome and rRNA processing machinery.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
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        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="InterPro"/>
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        </location>
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    </feature>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="287" mass="32115" checksum="6AF31D8C7C844EC1" modified="2011-10-19" version="1">MAADDKVDVISKKETKEKDKKKEKKEKSDKKDKKDKKEKDKDKKRSDTEGVHKDKKDKKKDKKDKEKLARALEAHLAAKKNEETALVHKTDSDDESEETVQIAGNLVPFALPLADAKTHKKIYKLIKKGAKLKAISRGVKECEKTIKKCPPKPVSAGQTEAPGVVVIAGDISPIDVITHFPILCEEHGVPYVFVKSRAELGMAACTKRATSVVMLKTECKKLASDNKTDKKPEEDAEDLKATQAEYLDGLKELVKIAQKEWEVQVQPWVKGIHPLQIEEKQKQSGMS</sequence>
</entry>
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    <accession>G0SEH8</accession>
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            <fullName evidence="5">Phospholipid metabolism enzyme regulator</fullName>
        </recommendedName>
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    </gene>
    <organism evidence="4">
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        <name type="synonym">Thermochaetoides thermophila</name>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
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                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="759272.G0SEH8"/>
    <dbReference type="GeneID" id="18260418"/>
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    <dbReference type="eggNOG" id="ENOG502QU5B">
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010513">
        <property type="term" value="P:positive regulation of phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903778">
        <property type="term" value="P:protein localization to vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000011">
        <property type="term" value="P:vacuole inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024260">
        <property type="entry name" value="Vac7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28258">
        <property type="entry name" value="VACUOLAR SEGREGATION PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28258:SF1">
        <property type="entry name" value="VACUOLAR SEGREGATION PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12751">
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="738"/>
            <end position="761"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="648"/>
            <end position="657"/>
        </location>
    </feature>
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        <location>
            <begin position="667"/>
            <end position="676"/>
        </location>
    </feature>
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        <location>
            <begin position="686"/>
            <end position="698"/>
        </location>
    </feature>
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        <location>
            <begin position="710"/>
            <end position="719"/>
        </location>
    </feature>
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        <location>
            <begin position="962"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="974"/>
            <end position="990"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGS18355.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1011" mass="108280" checksum="9A20973107DAD154" modified="2011-10-19" version="1">MDKSRSQKSHPTTIPSSDSANITTTTSSSTGPVHPTSSHELSSSASTSTSTATITPKPANNTASPANSKPPSTSASQQPSAAPSTSSSAVPSPLTSREPSPTRPSARPGAPSRTPSVSAGVRSRQGSVQDLRQSRSGISKPLSSTSIPTLQPSASDSSTFAGAPMKSPTSMEHIRDTPRWPVSPRLRSPPPMLQRPSLGSRRSTEVEATPLINVQRATPQQPPAEGQSDTDVDDGFLPAGMRTPARGGGGSTSTLETVQEVSPIGSPKRVGESMEEKLEESMLSETSQAESVIGLGLSRKPTTSSTTTSHATQHHRVNESGSESEYARNNYHQQRRSVGSIVPSLTRRQSSTRISPGIGRSKTGEMQSMTVETETVTSIPQAPLVPAIAAQTSSTSLRRKQSTETIRPKKEKRKTRRQPVNGEQKALPYSRLRHHQSLGSVVPSAADKGALPARRHRGEMADGRLRRQHGRASSLSLYQMSTLLTRQRLVSSKADIFEAKVASAVEEANSSDSEETFVYDSNPPDGRERPLRFHSRTPSATSMASQYDRGMRSIHAVMMESDGPPPMLVKKSMKFSSNSNNLNNDLGIMSDDGRVPGRSNVGSARGTPRHHNQHFNRWARNGGYGATSAGNGHPSVFAEHSPFTASQAVGNVGSRQPSAPPSPRYGPGRGFWGNGKRGAHLLPGYDFDDTTTGADDETTPLIPSSIRPSRYSRNRRGHSLRSIESQQYRSPPSVLNRFASCLVLTVMLLLVVSGVIGFMFATSQPLTDIELVSMDHVVASQQELMLDLTIRAHNPNVVVVTVDSADIEVFAKSPHALSDSEWWRHTHPGEIGPPPPRKGGVGDIEVTEATQPTPSPSPNPNQPDDSAPNMRLGTITGFDSALSFEGSFFHKGISYSSGEVRLKNPGNGTYGGPERWERIMEDEFQLILKGVLKYTLPLSQRVRTATISGKTTVKPNAGGDPAPKPDQPELPGPDEGGLNGNGTDITGGGEVNATSSTVLARTKRMRVRIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEQ9</accession>
    <name>G0SEQ9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0059370</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS17925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696256.1">
        <property type="nucleotide sequence ID" value="XM_006696193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEQ9"/>
    <dbReference type="STRING" id="759272.G0SEQ9"/>
    <dbReference type="GeneID" id="18259975"/>
    <dbReference type="KEGG" id="cthr:CTHT_0059370"/>
    <dbReference type="eggNOG" id="ENOG502S9GA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_510932_0_0_1"/>
    <dbReference type="OMA" id="MCEWITK"/>
    <dbReference type="OrthoDB" id="5396937at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="115"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="528" mass="60122" checksum="E898C66394631AB5" modified="2011-10-19" version="1">MEPLHMTEFGSDRYLEKINQQAQANANSAPPPPVAGLPQSKFILPIRGSGLSTTDEPAPRSQDQKRSEKKHFGFLRHKLHQRHALVVNPVKPDPTPATSKQRQVPNFLAFLIPFDQLFASLPNELQIEIIASLPLSDILNLRGASRSLHALVSLNEAPITRYHLDHHVPAYAKRLYPPPPGVPLNFHYLCGIWHRLHVAAKLSYLICEWVSKELFFRNTEEKRREFAPQRERMRRRLIPRLFTLFHFFETYRRLHLQYLIEHDGHGLRNTPHTLNPIEAQIMSMYDDRTLLLVHETFPLVISSFCRRLRPPTYVGLVERSLRGYLREKPPDEVHVAILCLGGLRQVERIWEIKGYNARRAAVDNWYASLTQDTTEQETKKRRGVLGGLKRKKSSLVLGKNSSCSGISTGASDSAPGSRRSSNGKAPESLVYCTSLAAGMPMPPLSPDEARLLLPDLPNLQDIWAKTAEALILERRIVERPSDIRRNAQIFTELIREDACDDEDEWLYGNAASDSVRPNLDAIEEDPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEZ6</accession>
    <name>G0SEZ6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative carbohydrate transmembrane transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0060250</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696343.1">
        <property type="nucleotide sequence ID" value="XM_006696280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEZ6"/>
    <dbReference type="STRING" id="759272.G0SEZ6"/>
    <dbReference type="GeneID" id="18260063"/>
    <dbReference type="KEGG" id="cthr:CTHT_0060250"/>
    <dbReference type="eggNOG" id="KOG1443">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022332_4_1_1"/>
    <dbReference type="OMA" id="QPIMVES"/>
    <dbReference type="OrthoDB" id="18894at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="408"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="464"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="501"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="539"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="568"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="596"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="10">
        <location>
            <begin position="336"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="151"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="200"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="673"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS18012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="725" mass="77704" checksum="7D7CA107B591D717" modified="2011-10-19" version="1">MSALPTASVGDPTPRPSSPIVPLPSGRSPPRPSSSASFSPSSSSSSSSSSYPLVRHDTAPPAVTSDNVNTSIYNHHNDYEAEHWRSEHSNQALLAGHIPGDSRHDPPNPPDLGSTAQPVTTTIEMDAITQSGHRRRRSSLINPASAATAAAANHLGRARSRSIRRCSPDGGASGSSSAADAKILEETGEEQPIMVESLRVGGAAGGGGGRGGGGGGGGGDISSRNHSDEDGLSDEDLHDDEETGLTDRERRRKRLKRLRNQQLDQRVAREHITREEKKEADLSVLKNLLINVLLIGLWYTFSLLISLVGFAPFSWDWDFANRRQYNKWMFSPDNLNFPFPMFTTATHMLVQFSLASLVLYLFPSFRPQHPRSDPSQPVMTKTFYLTRIGPCGLATGLDIGLGNASLQFITLTFYTMCKSSSLAFVLLFAFLFRLETPNWKLVTIIAIMTVGVVMMVAGEVEFKLGGFVLVISAAFFSGFRWALTQILLLRNPATSNPFSSIFFLAPVMFLTLICIAIPVEGAGNLIAGLGQIAEQKGALVAPLLLLFPGVIAFLMTSSEFALLKRTSVVTLSIAGIFKEAVTIAAAAIVFGDTMTLINMVGLITTLVAIGWYNYIKISRMRLEAQLDVHSEHLAAQHAAVERARRSDSLSPSPVGGRGEVEVGENVGLLAAAGAHHRRSMDDDDAPVGAANALNQGSGERVLFTGDGGDVVIAASPSHEVKGTPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G0SF04</accession>
    <name>G0SF04_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0060340</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696351.1">
        <property type="nucleotide sequence ID" value="XM_006696288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SF04"/>
    <dbReference type="STRING" id="759272.G0SF04"/>
    <dbReference type="GeneID" id="18260072"/>
    <dbReference type="KEGG" id="cthr:CTHT_0060340"/>
    <dbReference type="eggNOG" id="ENOG502SA5E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086075_0_0_1"/>
    <dbReference type="OMA" id="ISEADMF"/>
    <dbReference type="OrthoDB" id="5422320at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024526">
        <property type="entry name" value="DUF3807"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40642">
        <property type="entry name" value="YALI0F31295P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40642:SF1">
        <property type="entry name" value="YALI0F31295P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12720">
        <property type="entry name" value="DUF3807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="239" mass="26679" checksum="6B0394924EBABD49" modified="2011-10-19" version="1">MAGTSSIKVPQISAAEMAAFHENHFSYFATDHFVSHFLRPEFATAVKYSTNQYDTNENDSDAVDDEYYDEEDDGLGYYPDGVKRTLTDEQIAIFRHSELEALRRAKELEQEQQRAAAAASSARNQPNDNDHDDDYEEDSLLSEGALSALPTPPLQPVSAAASVSTSSTSNKKNNNNKKRKRGKQHNDGNDGGEVIDLRKRTWDVVDKGLEALDYGSEEDAAQQAETGAYQRRRISYDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFK6</accession>
    <name>G0SFK6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial distribution and morphology protein 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mitochondrial inheritance component MDM10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MDM10</name>
        <name evidence="8" type="ORF">CTHT_0071170</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the receptor TOM22 and small TOM proteins. Can associate with the SAM(core) complex as well as the MDM12-MMM1 complex, both involved in late steps of the major beta-barrel assembly pathway, that is responsible for biogenesis of all outer membrane beta-barrel proteins. May act as a switch that shuttles between both complexes and channels precursor proteins into the TOM40-specific pathway. Plays a role in mitochondrial morphology and in the inheritance of mitochondria.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. Associates with the mitochondrial outer membrane sorting assembly machinery SAM(core) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion outer membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="6">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MDM10 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697389.1">
        <property type="nucleotide sequence ID" value="XM_006697326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFK6"/>
    <dbReference type="STRING" id="759272.G0SFK6"/>
    <dbReference type="GeneID" id="18261155"/>
    <dbReference type="KEGG" id="cthr:CTHT_0071170"/>
    <dbReference type="eggNOG" id="ENOG502QUN5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026505_1_0_1"/>
    <dbReference type="OMA" id="VPGYRQI"/>
    <dbReference type="OrthoDB" id="2103793at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051654">
        <property type="term" value="P:establishment of mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03102">
        <property type="entry name" value="Mdm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027539">
        <property type="entry name" value="Mdm10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28035">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28035:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12519">
        <property type="entry name" value="MDM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1 6" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="257"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="392"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="452"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="417"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS17771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="562" mass="61027" checksum="D557BE1C549BA771" modified="2011-10-19" version="1">MREFMNYITNAFYGATNWSDDNTYKELNATARELIDFPLPRGLRLTLSSLATSNFATSYQLGTVGIVDGSISYLYSTVPLAGIAAQSDRIPLQALLRSYRQIRDLGAAEWPWFPFPGVDKPSTPKGGSSPRAEKENSDEGAAEKGGLGASLGLGLSQEGEKKWLLYGRLYLPQSLLEGLVVRRVNSCLQVQLAAVSERSLRNGGTILGLVQYDRGKYGVEGLASTDGGLLGIRGLYNFGGDTVPFAAAVTTNVSQSTTATQTQGSGSNADSNPTSNGTTNGHSFSPSDRERDRIYGRFSIGGELYYGTLNKSGGMSVGARFQTLPAHRGTPLTATLTLNPLMGNISATYAVRARDYCSLATRMEFNVYSYESDWAVGMELWSNRRPGGFLLGRDPRRPVEGDVDGGESARAEGLPGSEQSKAAQEQTRTQMHPKPWWMERSFQAKLEWRLDEECKGPSSPAPPAPANGPWQNAPSTLVPVSKGQHPTTTTTPLSMETGNNDPDDDKEQYRGVLKARLDQNLKMGLLWEGRVKSLIFSLGTGVDLRKLGEPFRSLGLEVQYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0SG49</accession>
    <name>G0SG49_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0065030</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696806.1">
        <property type="nucleotide sequence ID" value="XM_006696743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SG49"/>
    <dbReference type="STRING" id="759272.G0SG49"/>
    <dbReference type="GeneID" id="18260541"/>
    <dbReference type="KEGG" id="cthr:CTHT_0065030"/>
    <dbReference type="eggNOG" id="KOG0534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_7_1_1"/>
    <dbReference type="OMA" id="WIDFFIP"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00322">
        <property type="entry name" value="FNR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052128">
        <property type="entry name" value="Oxidoreductase_NAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46505">
        <property type="entry name" value="OXIDOREDUCTASE NAD-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46505:SF1">
        <property type="entry name" value="OXIDOREDUCTASE NAD-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="4">
        <location>
            <begin position="19"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS17188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="337" mass="37133" checksum="789169947A02A12F" modified="2011-10-19" version="1">MSTAKETHAERTAHEPRDPSLYFLNIASITLITPSIRLFRLALPPSNTLSFLPGQWIDLYVPPSDHILFNKPGGFTITSSPSHAAVASTPEDYILQSGANDNEPMKPYKYIELAIQHAPDNPVAVYLFRPVSQLLNTEVTVRVGGSFVFPPAGDIPFKIVVFVASGMGINPLISMMSWLGEQGKDSRWRGLEVRVLYGARVSRDAWSQEAVGAEMALRPANSLLDPCKIPFLPRIAKLFSSGKLQGQVTLFLTGLNSASNPTGDVIPCENLEIAYLRRRMTLTDVQAAIGEKKGQDNSVVYVCGVPVMTDEFVGRLAAPEPEGFGMDKRRVLFEKWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGB1</accession>
    <name>G0SGB1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0065690</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696868.1">
        <property type="nucleotide sequence ID" value="XM_006696805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGB1"/>
    <dbReference type="GeneID" id="18260607"/>
    <dbReference type="KEGG" id="cthr:CTHT_0065690"/>
    <dbReference type="eggNOG" id="ENOG502TGWG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_865999_0_0_1"/>
    <dbReference type="OrthoDB" id="4773142at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS17250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="321" mass="35934" checksum="9BEDF56F878101D4" modified="2011-10-19" version="1">MTLSTCDFYFAFGPEPGSFVLDTPRTVRHSKAPYRIEKALREVKKVYWAVWNEKGHASFSLCTSRGVSEWISDGLDSDNPELAAILQYWLRRLNPEEVSLTLGPGDAYVMCLPTKNKVFYNGLNKNLATSLCGIDNVQHVALGIGGDFVIVSDGRVESKALDNYPELRRILAERSYCKVLYITLNPWRPEQYFVVLSDGTVYFKVDYSVDAAIRPVLQDVLGTIDFDSVSDGDSLYSKASLASSTNKAREMQWQEHNEIREIPPMYDDMRQREGRGRRWGRRAVRVAQAAAATGVVIAATATGVPIGIEEDCIVMVKMISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGG7</accession>
    <name>G0SGG7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha-taxilin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0066270</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the taxilin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696924.1">
        <property type="nucleotide sequence ID" value="XM_006696861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGG7"/>
    <dbReference type="STRING" id="759272.G0SGG7"/>
    <dbReference type="GeneID" id="18260665"/>
    <dbReference type="KEGG" id="cthr:CTHT_0066270"/>
    <dbReference type="eggNOG" id="KOG1850">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029275_2_0_1"/>
    <dbReference type="OMA" id="VQYNMAR"/>
    <dbReference type="OrthoDB" id="425555at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026183">
        <property type="entry name" value="Taxilin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16127:SF13">
        <property type="entry name" value="GH01188P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16127">
        <property type="entry name" value="TAXILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09728">
        <property type="entry name" value="Taxilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="387"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="399"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="446"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS17306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="510" mass="57899" checksum="D6C26C1002961F0C" modified="2011-10-19" version="1">MSTPNPSTAPTNGRPATESVPPNGQSGAAQAVPAAAAPSGKKGKAKKMPEPSEASKLIAQRISQLEMDAALDKDQEAELEREVRKANRELQNQTAKMMDMQKIEFLTKRCSDLFMEMKRHERESIKNKKRTDQLQKDKDNSRQELNKTVSLKEKLEKLCRELQKENNKLKVLSHDSTDGMGKKQDADEFYVGRTRTKLLQMRKFGARLRGTSGIQAFCVEWMNIKKTKITHRFKSLIDQYELRELHFHSQMRTKELEVQYNLARYEQQKKNYEAEYARSRQLNAQVQAFTQTEADLRHQLSVYVEKFKQVEDTLNNSNDLFTTFRKEMEDMTKKTKRLEKENEQLKRKHEQVNGNILKMAEERNRNLSEIEELRKKLDKLNGIIKQMQQQGRGIPQGMASGTNAGTNASNGTSSNSNAAATQNGHHGGHSHGSSHGSHAENGHGEEEGDGSEYDEDEYDEGEEEGSEEGEFDDETEDELHQQGPQQPQPYGPERPLRAAPAAAATTNGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHD2</accession>
    <name>G0SHD2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0069610</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697239.1">
        <property type="nucleotide sequence ID" value="XM_006697176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHD2"/>
    <dbReference type="STRING" id="759272.G0SHD2"/>
    <dbReference type="GeneID" id="18260999"/>
    <dbReference type="KEGG" id="cthr:CTHT_0069610"/>
    <dbReference type="eggNOG" id="ENOG502RTVH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031716_1_0_1"/>
    <dbReference type="OMA" id="EALMMRM"/>
    <dbReference type="OrthoDB" id="10261384at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034627">
        <property type="entry name" value="Irc6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28043">
        <property type="entry name" value="INCREASED RECOMBINATION CENTERS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28043:SF1">
        <property type="entry name" value="INCREASED RECOMBINATION CENTERS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10199">
        <property type="entry name" value="Adaptin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="390" mass="40996" checksum="8E57C3C1F7FCA336" modified="2011-10-19" version="1">MPPREQKKITNPRRILAVSLADSANHLSDVIKALTGTAPSPSLSPDQDSSSLAGTTHHITLSTPYYTASVPIWIDLIPSSSSTDNAASSSSSTPSPASEWASTFLSEEAKEVLAVLGGLILVFVIPPPSVTPTLSSLPAAAAVPQPSQPPPSSSDPEPTASTQPSTILALPDPISPLIPSPSLTRDLITQIGRLIHQGLGGWEWDGVTLAIGISVVGPASAGSQLDDDDGEDVLNGWEDLCAENGMEFVHIPVSALKDKKDKEGEKKRNKFGERVGLERVLEALGSNDWSGGGGGGGGLQGGEGGMLTWKGRDRKGDLDELKKAILGGGGGKHDDEEEEEGGELGEEDVEKLERMMRKLQAVRDATAGMPEEQRKRMAKKAVGEVMRELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHI2</accession>
    <name>G0SHI2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">S-formylglutathione hydrolase</fullName>
            <ecNumber evidence="2 7">3.1.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0070110</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Serine hydrolase involved in the detoxification of formaldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-formylglutathione + H2O = formate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14961"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="3.1.2.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the esterase D family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.12" evidence="2 7"/>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697289.1">
        <property type="nucleotide sequence ID" value="XM_006697226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHI2"/>
    <dbReference type="STRING" id="759272.G0SHI2"/>
    <dbReference type="GeneID" id="18261049"/>
    <dbReference type="KEGG" id="cthr:CTHT_0070110"/>
    <dbReference type="eggNOG" id="KOG3101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056472_0_1_1"/>
    <dbReference type="OMA" id="PSDCPWG"/>
    <dbReference type="OrthoDB" id="420518at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018738">
        <property type="term" value="F:S-formylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000002">
        <property type="entry name" value="S-formylglutathione hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014186">
        <property type="entry name" value="S-formylglutathione_hydrol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02821">
        <property type="entry name" value="fghA_ester_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061:SF0">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0719">Serine esterase</keyword>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR614186-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS17671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="297" mass="32524" checksum="ACBD38F2FCE2A280" modified="2011-10-19" version="1">MASAFTIKATIASFGGKLFKLSHNSATTTTPMALNLYLPPKSFTTPTPKVPLLIYLSGLTCSPENCSEKGFFQHRASQLGLAILYPDTSPRGLNYPGETDSWDFGVAAGFYLDATREPWSGGYKMETYLTSELPSTLFNDTEFGKYLDAEKVSITGHSMGGHGALTLYLRHPELYKSVSAFAPISNPVNCPWGQKAFAGYLGEEDKEAWKEHDATELIRKGVWKGKGDMKALVDVGLADGFYKQGQLLPENLEAAAKEAGVEGLTVRYHEGYDHSYYFISTFAAEHVDHAAKHLGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHJ9</accession>
    <name>G0SHJ9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0070280</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIAS family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697306.1">
        <property type="nucleotide sequence ID" value="XM_006697243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHJ9"/>
    <dbReference type="STRING" id="759272.G0SHJ9"/>
    <dbReference type="GeneID" id="18261066"/>
    <dbReference type="KEGG" id="cthr:CTHT_0070280"/>
    <dbReference type="eggNOG" id="KOG2169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020537_1_0_1"/>
    <dbReference type="OMA" id="TCARITS"/>
    <dbReference type="OrthoDB" id="28127at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16792">
        <property type="entry name" value="SP-RING_Siz-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.780">
        <property type="entry name" value="PINIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023321">
        <property type="entry name" value="PINIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038654">
        <property type="entry name" value="PINIT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031141">
        <property type="entry name" value="SIZ1/2_SP-RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF4">
        <property type="entry name" value="TONALLI, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14324">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51466">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SAP" evidence="10">
        <location>
            <begin position="205"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="PINIT" evidence="12">
        <location>
            <begin position="386"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="SP-RING-type" evidence="11">
        <location>
            <begin position="565"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="267"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="648"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="271"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="323"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="695"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS17688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="771" mass="84281" checksum="E5538D5AF620700A" modified="2011-10-19" version="1">MYRRPTLQGSCQHGLDWRTRFLPENAAFLFGSSSADLIEEQHCARAIAQGEGQHRQRPVAGSSAYQSPSPLHQKYIRLRGHVTAIAGITLTKGATKQSFAYVATPLPKGQLILRRPKQQHSAPLARRIGTPATPLIRKLIPVTHRHLSSSVTLDSSSIRQSLLHAPSSTKHLQRGPPSAGSDKKWATRMSDRSAEVQSLIRTIQIPAISKTALQAICTMNGLPKTGNKSDLQRRIIAHINSCSAENDWQRLKEVRESIIQRAPIHTHHLVSSAQSQPQSTSQTRSQSHAQMQSSSSAQPSAHQAHPTHQPQSYPQPQSHTTSLSPAHTLSLPSQPQPSATYYPPPTSRQSHYALPGYPPAPYAPTTPTSLPRPANPQTVPYHTMGTAASRSRPAGGYIAPTITYKPSPFYEPLYQVGEVRTLEIMTSHKNTKVIPIKVQDHPALQLCVNDHSMRLMVFCAGGNTGVQDVAFPYQCELKVNGGEIKANLRGLKNKPGSTRPVDITDALRLKPHYQNNIEITYALTQKKFYVNLIVCKTMSIETLVDKIRNKIRKDSVVAEITKKASDPDVVAMAQNLSLKCPLSYMRLKKPVRGIGCSHIQCFDATSYLQLQEQGPQWLCPVCNKPAPYEQLAVDEYVQEILLKTPESAEQVTIEPDGQWHQPDAPRAASTPRRPQPTASYSVDDDDVVEISKVVSGPSRSTATPSAAPLSSSATPLMATPPSVASAATPAPRSSNKRPPPEVIDLTLSDDDEPPRPVKRANYGTGCSGGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHP7</accession>
    <name>G0SHP7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0072920</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS16967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697549.1">
        <property type="nucleotide sequence ID" value="XM_006697486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHP7"/>
    <dbReference type="GeneID" id="18261330"/>
    <dbReference type="KEGG" id="cthr:CTHT_0072920"/>
    <dbReference type="HOGENOM" id="CLU_1488833_0_0_1"/>
    <dbReference type="OMA" id="CHNYWKP"/>
    <dbReference type="OrthoDB" id="4559902at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409205" evidence="2">
        <location>
            <begin position="34"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS16967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="181" mass="20985" checksum="8CB70216BE7DC549" modified="2011-10-19" version="1">MVLKRPALCLLLGFNSWTAIQAWIAEVVAPAHAVLVEDWLKPAEEHGWVDLLGSEIMKEYFVQNADELEAKVQQRVWEITSREREEPLRGDPNDVWDILGHYERFIIDSIALDRIAEEQSPSRHHIANKEWSRNPETLFGYMYELTDTLCHNYWKPAETDQWNSDDSDVPYTDPADIPGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHS6</accession>
    <name>G0SHS6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phospholipase C-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0073210</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS16996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697578.1">
        <property type="nucleotide sequence ID" value="XM_006697515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHS6"/>
    <dbReference type="STRING" id="759272.G0SHS6"/>
    <dbReference type="GeneID" id="18261359"/>
    <dbReference type="KEGG" id="cthr:CTHT_0073210"/>
    <dbReference type="eggNOG" id="ENOG502RZSI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024117_2_0_1"/>
    <dbReference type="OMA" id="TCHVAPP"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08586">
        <property type="entry name" value="PI-PLCc_BcPLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF113">
        <property type="entry name" value="SI:DKEY-266F7.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidylinositol-specific phospholipase C X" evidence="1">
        <location>
            <begin position="206"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS16996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="570" mass="62494" checksum="2605445D1B80E528" modified="2011-10-19" version="1">MGVVNSCPIPSSSIPPVPPTLTIRNLTVTPLHLIEVEHLTRHHHLIPKSDALTRIPSRISRHSTDSRRRVSHDAQHMHYREADGSVAATPFLPDHDHDARAAHPLDVALPPFGEALIPIPPPALHGRHTHLRMTFLDPTTGKRYQGIIPGSAHRTIVLQPARAPEDEPQPQGEDAHEFTAIYLPTRGFLALFSSANLPSWMGTLPDHLPLSALSIPGTHNSPTYHVALPSVRCQAVSIESQLVNGVRFLDVRVSCPIFSPPPEGSSASAQAAVPVPELALVHAFFPVSLIPNPQKHTLRHLLSITYHFLDQHPTETILLSLKREGTGLGTDADLAQILVTYYIPPNRSKWYISPHIPTLGEARGKIVLVRRFNLPPPSSPCPALLEEGGERGLGIDASVWPDNVPDGMCGSGLVRIQDWYGVWNTSDIRKKIQYAQEGLERAAERVFDMEPFLPPNLPLFDGQAESRLANGDPAVQQRQRPAAPPFYINFLSASTLFNINCWPDRIAVKINPSMIEYLCMAHGAPGKGPGGLSVGDAATGIVVTDWVGYRGDWDLIRCIVGWNARFGLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHW5</accession>
    <name>G0SHW5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative UPF0658 golgi apparatus membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0073610</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697617.1">
        <property type="nucleotide sequence ID" value="XM_006697554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHW5"/>
    <dbReference type="GeneID" id="18261399"/>
    <dbReference type="KEGG" id="cthr:CTHT_0073610"/>
    <dbReference type="eggNOG" id="ENOG502RRZT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029564_3_0_1"/>
    <dbReference type="OMA" id="IYCARTE"/>
    <dbReference type="OrthoDB" id="2448307at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040410">
        <property type="entry name" value="UPF0658_Golgi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391:SF1">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="338"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="505" mass="56858" checksum="58457E953DC1C0C3" modified="2011-10-19" version="1">MVNIAVVSVGGADDDDESERGPQPNRGLGTPWLPWGIPCTAPDPAKTREPLRVLDAAPVLEMGIAWWSHAQTSAASEPSARAFLSRSFPASKPPALASQREVRRSYLAGSQPISSFDGSSMYYGGPQYRDTDPEFIMPSATAQGTGRAAKPKLFSKEFLASRWAKLFFFVVGMQALIGVVFEAYVFGRFQFSLDYQEEREHLFTPLEKSQYRTIPTFLTLFIFGYLYILVLTWDALRLKNTIQIIGLCFSNLALFVYSVLQIDQIDKSIQKLLAAGAIKPDKEDRNVWALCKPFLIAIPVVVGVVTVAMSVLAYQLYREFAWDILKLIGADYRMTKRFLHYQIYIALLKFDFFFFLGFTIQFLVVVNGIKDFELGLHIAAIPITVGILLCAAFFTRRENRLGVCFVILLYFGGLAYFFFKLVRIYQPGHYQNYLAVRRSLTAFAVLTILLIILTIINAFICMSNFGKGLKAHLVKPNGPDPEKEDANSYQLHEQKPPLSSRMTID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0SI07</accession>
    <name>G0SI07_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0074050</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697659.1">
        <property type="nucleotide sequence ID" value="XM_006697596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SI07"/>
    <dbReference type="STRING" id="759272.G0SI07"/>
    <dbReference type="GeneID" id="18261443"/>
    <dbReference type="KEGG" id="cthr:CTHT_0074050"/>
    <dbReference type="eggNOG" id="ENOG502RS8E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089690_0_0_1"/>
    <dbReference type="OrthoDB" id="4587143at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="271" mass="29887" checksum="CEA501F468461FCA" modified="2011-10-19" version="1">MRELVAIDTSVTSNRVRLVFSDRAVAAAYAAYLRALDLLPPQRRHPQLVNYQRMPEFRAPTKEVTFCLPEFISWFITCRLPDDEDTVTFGVNPPHEAVAAYWADSMVLFEEVVSPDSSPPPPSDTSLASPSSRRNRRGASRDRSYCHNQEEQLHVRRLWNKTRLLRRLEELRRRVTAPVTAPASGQTTPVNNRSRVTSPVWNGSGYVLINSGGKSAGGSGKGSPASTGAVSTSHHGHHHHQSVIGGVSGRVPVPVPLTVPAGRMRGGDIWW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-06-17" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>P9WF01</accession>
    <accession>G0SA92</accession>
    <name>CAPZA_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-actin-capping protein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ORF">CTHT_0041430</name>
        <name type="ORF">CTHT_0041430-2</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the F-actin-capping protein alpha subunit family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EGS19664" version="1"/>
        </conflict>
        <text>The predicted gene CTHT_0041430 has been split into 2 genes: CTHT_0041430-1 and CTHT_0041430-2.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19664.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P9WF01"/>
    <dbReference type="SMR" id="P9WF01"/>
    <dbReference type="OrthoDB" id="878at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1140.60:FF:000004">
        <property type="entry name" value="F-actin-capping protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.210:FF:000003">
        <property type="entry name" value="F-actin-capping protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.60">
        <property type="entry name" value="F-actin capping protein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002189">
        <property type="entry name" value="CapZ_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042489">
        <property type="entry name" value="CapZ_alpha_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017865">
        <property type="entry name" value="F-actin_cap_asu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01267">
        <property type="entry name" value="F-actin_cap_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00191">
        <property type="entry name" value="FACTINCAPA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00748">
        <property type="entry name" value="F_ACTIN_CAPPING_A_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00749">
        <property type="entry name" value="F_ACTIN_CAPPING_A_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0117">Actin capping</keyword>
    <keyword id="KW-0009">Actin-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000450357" description="F-actin-capping protein subunit alpha">
        <location>
            <begin position="1"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q10434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="274" mass="29939" checksum="66FF7DE23ED66DFF" modified="2020-06-17" version="1">MTLQSQKAILSSFIEGAPPGELADVVADIKNLTSSTPNLINELGPAFQKYNEEQFTTVKLPGSSQHVIISSHNSLGGSRYYDVETSTSFAFDHTTQKASAVETYVVEGAQGDLTKSVIKALAPYVKEHYSNAAYGAWPIENDSKVAIIIVANKYSPNNYWNGRWRSLYILDPAAGTVEGSIKVDVHYYEDGNVRLLTDKPVTASVSATGAAIVKEISAVEKKYQEELNRSFASLSEGAFKALRRQLPVTRQKIEWEKIAGYRLGQDIGGGGARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0RXS3</accession>
    <name>G0RXS3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0000200</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 10"/>
    <dbReference type="EMBL" id="GL988030">
        <property type="protein sequence ID" value="EGS24089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690575.1">
        <property type="nucleotide sequence ID" value="XM_006690512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RXS3"/>
    <dbReference type="STRING" id="759272.G0RXS3"/>
    <dbReference type="GeneID" id="18254058"/>
    <dbReference type="KEGG" id="cthr:CTHT_0000200"/>
    <dbReference type="eggNOG" id="ENOG502QSWP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025694_1_2_1"/>
    <dbReference type="OMA" id="NWIRDVG"/>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF36">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409108" description="Mannan endo-1,6-alpha-mannosidase" evidence="13">
        <location>
            <begin position="23"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="412"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS24089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="473" mass="52414" checksum="A65FB28B5330F186" modified="2011-10-19" version="1">MNRFLASIAAALLFLTAACVHAQDGRAKLQVDLDDYDSIRRAAKIVAGNLWTYYHGDKPGQTPGILPGPHPAVPSGPYYWWQAGAMWGTLIDYWYYTGDDTYVNETRRSLVFQAEGPGYSFEPRNWTLSLGNDDQGFWGMAAMLAAETNFPNPAPDEPQWLALAQAVFNRQARLWDMEFCNGGLRWQIPHTNAGYNYKNTIAQVVFMNIASRLARYTRNDTYARWAETAWDWTQGVGYITKEYNVLDGGHVEHNCTDINPVQFSTNAALLIHAAAIMYNYTLEEKWRSRVLGLLNRTIDHFFPEGIMVERACELPDRMQCNVDQHSFKGYMHRALATVAVVAPFTRDTIMRTLRSSTEGCVSSCLADGTCGFRWNIGKYDEDVANGPAGQQMSAVAALSTLLLDQPHVLRGPLTNDTGGTSRGDPNAGLVNNDPEPMRPITVGDRAGAGVLTAVILGSFLGGLLWMGMGWSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0RY53</accession>
    <name>G0RY53_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Post-SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0005460</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691081.1">
        <property type="nucleotide sequence ID" value="XM_006691018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RY53"/>
    <dbReference type="STRING" id="759272.G0RY53"/>
    <dbReference type="GeneID" id="18254584"/>
    <dbReference type="KEGG" id="cthr:CTHT_0005460"/>
    <dbReference type="eggNOG" id="ENOG502S11B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073382_1_0_1"/>
    <dbReference type="OMA" id="GIWLNGH"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053201">
        <property type="entry name" value="Flavunoidine_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12350">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12350:SF19">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Post-SET" evidence="4">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="240"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS23839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="303" mass="32709" checksum="238E4B6E02A177E8" modified="2011-10-19" version="1">MAPIKPHWVQPSHPDIQQVIVTGNAEEFTTKSISKIALPPFGLFARLDFPPCTPAPVPTYATVQIGRDKHIDLNSDLLYINHSCEPSLIFDTSSMLVIAGPKGLKPGDELTFFYPSTEWEMAQPFDCLCGAPTCRGRIAGARDMSLKQLEGLWLNRHIRDLLEERERDRALKAGKLFGNYTLSNGYSNGNGYTNGNSALLPTLDLDQTVLALREALAQAEKVVEVARSAITSYAVSCQDDDSTFRNGKNGKADGRAANGSGSSSNGNGYDAPAPTPPGLQRRGPTSRELAGEEGGDTSSRVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0RY61</accession>
    <name>G0RY61_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gem-associated protein 5 TPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0005550</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691089.1">
        <property type="nucleotide sequence ID" value="XM_006691026.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0RY61"/>
    <dbReference type="GeneID" id="18254593"/>
    <dbReference type="KEGG" id="cthr:CTHT_0005550"/>
    <dbReference type="eggNOG" id="ENOG502QVI0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000799_1_1_1"/>
    <dbReference type="OMA" id="PFPGELQ"/>
    <dbReference type="OrthoDB" id="7326421at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034605">
        <property type="entry name" value="PGC-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056421">
        <property type="entry name" value="TPR_GEMI5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15528:SF11">
        <property type="entry name" value="FI18188P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15528">
        <property type="entry name" value="PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1 PGC-1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23774">
        <property type="entry name" value="TPR_GEMI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Gem-associated protein 5 TPR" evidence="8">
        <location>
            <begin position="472"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="278"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="736"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="773"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="991"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1290"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1345"/>
            <end position="1589"/>
        </location>
    </feature>
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        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="810"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="823"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="845"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="866"/>
            <end position="875"/>
        </location>
    </feature>
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        <location>
            <begin position="876"/>
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        </location>
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        <location>
            <begin position="930"/>
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        </location>
    </feature>
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        <location>
            <begin position="1027"/>
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        </location>
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        <location>
            <begin position="1057"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1080"/>
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        </location>
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        <location>
            <begin position="1131"/>
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        </location>
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        <location>
            <begin position="1159"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1301"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1381"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1392"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1411"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1451"/>
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        </location>
    </feature>
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        <location>
            <begin position="1472"/>
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        </location>
    </feature>
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        <location>
            <begin position="1485"/>
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        </location>
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        <location>
            <begin position="1496"/>
            <end position="1506"/>
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    </feature>
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        <location>
            <begin position="1507"/>
            <end position="1525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS23847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1646" mass="179709" checksum="20078D69CD2E0B42" modified="2011-10-19" version="1">MASPSSSRHNPIRRYFEPCAATASMFLYAQGTSVVCCNHDTLAIERRFARHSEEIQLLAVDNHSDIGAGRLVVSYDAGQTAIVWDLLTGDEIARFVSYEHITCAAWMRDGNVAFGNTQGNVILFEPTTSEHLSTRTLDQIPVTAISPHADCRTFAIGRTTAICECGASLSRTANDDPAKVVRILKRTENYVVGPNWAAWSKNGRIIQYSEGETISWDVRTKHVTLDVVPTLDVVRGLAVYGPDAVLFTLGANNTVQQFNLSAPILMVANVQHPAPLLPPSPPISLESEEKTQATASESESNVQIAFRPSDVSESEDDNRLPLARHLQNTSNAGMCRPTTPASHISRSSVSISSSTSQVAARRYQASVTSRGLTENTYISAGSSLHSGHPLHCEREPMSTTSSISVGSSLRHQVHKPSILRHEVPRNPDDAKVTDLFKFTRARLSDIPYKAPYALENGRLTPDELRRQMLSTIFGWNKDIEELVRDEMSRHPLGSTNRILLAKWLGDISTDVMAMGSEKMTASDWMLLALSGIGSASGQQKLGRAYVQRLLESGDIHSATTILIGLGDYNDAIEVYVSHKKWMEALIVTCLFYPQAWERQSQIVKKWGEWAVQHGQQQLAIRCFACTDSGREPSEPWTSPSAQQLDFPNIVKGPELASPPLSPPVINHGPQRNVGKSSALKLITSFGDSNAKAKYFGQMTDDGKTPVAGGTTPILESALSPGGEPTTAILRGNRSAFNTPASARPPMGFNRPRLPSIGESSPDRVILTAVMPPSRDPYASAQHSEDAIRNAEVTRPNTASPRLVREPKRAPSPSASAMAAPMDPNRDRNGSRSRIPEGVDLSLKTLNDDVAREDVTSPEPSGQSSTHRYHWPKRRGPGSVASSVSAASSGASRARGCHHPGRSLDEYIHSLDAASSTSSMHKGRAGSRDPSLSRDRDTSRERGRPLMRGFTPKGGKRSPKSPVPMSPEDLINLSTPREDLEQLHHHQDKLIDVSNDEMEISREPSTVRNAGYRDGSAVRAASQIRTGASSRASSRAQRISPPLNLRGRSSSREPSGKKSPNSPQPISSLGPHYYGSEDEEDYRRAVEEQERFRQKHSRSTSRTGRGAEGITSPVSGHDPLSAQSGGLRRSNSHAGTNTMRSQVQTPAPMQLVTDSSGDLKVIKDERQLKKEAAARELEERRKSLARRPSAPPIVHPDQLTAQAKDKVQQPQQQQQAPELMSLPSTTYVPPKKEDLPSRSASVDPNVGRGMYASRNGPPIGLPATPRAMRLAMEAEAHRNNIKMPSIGQTLTQATSAPPFRPYAERDRQSPKKFDRDNNKDIPMLLPATVYTPPSNNQRLAAQISRSMSAPPQNLVMPERASRRPSHDQSNAGFAGSRRPSHDQNASNNNNITPPSPPPPVPPVLKELQHLATPPPPPPPPLPHLAASNAPKPIVYGGSSGLIEIVMEDESEQQQSHSPGTRPTSPLKQVNSSPPSPPSPPPPPPQQQQQQQQQQQQQPPPQPQPQPQPQQQSQQQPQQQQPQQSQPQPIPVAIPLRENTVPIIPPPAPPSRGHNRGRSSTDNSIGARITRATERMRSVSRSRGAQREREVPISVQVSAPYESVPPMPVQMQMQTQVQNQVFEKVQQQVAQAQAGGEFRTGLKQSEMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYJ7</accession>
    <name>G0RYJ7_CHATD</name>
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        <submittedName>
            <fullName evidence="3">Heterokaryon incompatibility protein HET-C-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0006940</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
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        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006691162.1"/>
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    <dbReference type="AlphaFoldDB" id="G0RYJ7"/>
    <dbReference type="STRING" id="759272.G0RYJ7"/>
    <dbReference type="GeneID" id="18254732"/>
    <dbReference type="KEGG" id="cthr:CTHT_0006940"/>
    <dbReference type="eggNOG" id="ENOG502QRXF">
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    <dbReference type="HOGENOM" id="CLU_010063_0_1_1"/>
    <dbReference type="OMA" id="AFIKGHK"/>
    <dbReference type="OrthoDB" id="2506204at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010816">
        <property type="entry name" value="Het-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052577">
        <property type="entry name" value="VWA7"/>
    </dbReference>
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        <property type="entry name" value="NG37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905:SF7">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07217">
        <property type="entry name" value="Het-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409137" evidence="2">
        <location>
            <begin position="29"/>
            <end position="764"/>
        </location>
    </feature>
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        <location>
            <begin position="587"/>
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        </location>
    </feature>
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        <location>
            <begin position="615"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="651"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="754"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="764" mass="83193" checksum="2A87C7BE94DD2AC9" modified="2011-10-19" version="1">MAGLRLGWGTMLLAFAILLVVLPDKAAAFGAGNIPSIAQVEGHNWRHGDIEDTIKTLAFLYGKKWSSMMIARVYFGNWLRDYSQAVDVGSLTKVNAATIRVLVWVLSFLANGYATGEFEVTEERLGVYRPEEHIDNPLGYADGQDARKYDPRLRAPVDKRELEIDPRTGMKNYIANESGGWATSAGYLRWSFARSIHFGRVYTSGAHGTSGRESDLCEALRCLGQALHCLEDFPAHSNYCELALIELGYRDVFPHVGRDTKINLRGKMVYPLVTGTFGAVDFLHSVLGEANDHFTQSEIDEMDTALRNAEHSGDGSYSSQRGFFGSSSNSGNDFISLLSQMPTVGNDFAAQARNLRAAASAQEQENARVSGSPDVNPTFDAVKIAAQIYPILEFRDKIVRAISNTISKIPGLENLLESISERLTIFILSLLAPFVRPLINQASKLLKEGSSGLIETSASSQFEPWNNPRCDNPTHSMLSKDHFTNILNSCAGRVAATIVAYVVPRVVYAWENPGVPVDEVVNDVLRALHHPAARDERVEIQREMFETVRKWTQETPYRHQLNHLLSAESVRNHKNHVLSSEMQQLQLSASTSSRGVPGHGGCGHGLEGHGKPANSLWNQLKKQGQLSLQTENTRPSSTGTHGSAHSPVSMTGHAASYYSSATTSSPSPAYSSGAGYGSPHHVQSPTGYGHGHGQAAGYYHPQTSPPAGYYGQQQPAPYGGHHGYGQAPASPHGYYPPGPGHHGGYPGSPHHQGPPGGGWGYPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYW5</accession>
    <name>G0RYW5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0000810</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690635.1">
        <property type="nucleotide sequence ID" value="XM_006690572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYW5"/>
    <dbReference type="STRING" id="759272.G0RYW5"/>
    <dbReference type="GeneID" id="18254119"/>
    <dbReference type="KEGG" id="cthr:CTHT_0000810"/>
    <dbReference type="eggNOG" id="ENOG502SNJU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_401131_0_0_1"/>
    <dbReference type="OrthoDB" id="5377599at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057218">
        <property type="entry name" value="DUF7896"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42031">
        <property type="entry name" value="KEY LIME PATHOGENICITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42031:SF1">
        <property type="entry name" value="KEY LIME PATHOGENICITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25438">
        <property type="entry name" value="DUF7896"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7896" evidence="2">
        <location>
            <begin position="335"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="686" mass="72997" checksum="11B9574D9CD64878" modified="2011-10-19" version="1">MASASNPQSSNGSSRGPVPTIVTQPITAQQQSLSQQRPIRNFLSTAPAIFPVQQQPSSIMGIEMDPAEFLIKADLLSSTAPPIDISQPHSFLSSDVALDQTIASSFRSMESMTTAPTVDTAPMTQSSTNMSNMPIGGSEMLRICSRQSFHSLPQDNGVQAFMAPAVPDKRRSDASLLSYPTFSVASPISQRPPTTQLSQSVPAAMGFVPADTTPSSQGLGSAAMERSISSQSARSASSIQNSLARQNSNAARQRVIQPRPNQPDGTTYCDSNGAPPTAGAHSSSPPRPRTAITRVRPERPNRQKAVCSICPDKPTFRGDHELRRHTQVKHSVKLEKWMCIKPPADEMHLRAKPVIPLEKCKQCSTKKQYNKDYNAAAHLRRKHFNVRQGRRARGQAGDQPEEKRGGRGGGDQPPMSELKHWMKKVIVYLDQRAAELAQVDEDGDGDEESELFPGDWDSQPGVDGRAPASIAGEDALVLPTADAGGNGAQLDQIAVFGVGDVFSSQDWNPLAIDTNTGLYDLEHELGNAATAVLSTGQDIRAANSQNDMLSPPVSPVNGIAMSFASSPVTPAGVDAQPQCQPRLSPATPALTMSLSGASSPESTHLANGMGQQNPFMTTSTTTTAGTMGMTKSQLDGTSGFTDAFSTTQGATAMLPVMGSTNQRLGMLQGDLGDMDFELTFGDLNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYY8</accession>
    <name>G0RYY8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoate-protein ligase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0001050</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690658.1">
        <property type="nucleotide sequence ID" value="XM_006690595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYY8"/>
    <dbReference type="STRING" id="759272.G0RYY8"/>
    <dbReference type="GeneID" id="18254143"/>
    <dbReference type="KEGG" id="cthr:CTHT_0001050"/>
    <dbReference type="eggNOG" id="KOG0325">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035168_0_2_1"/>
    <dbReference type="OrthoDB" id="19908at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033819">
        <property type="term" value="F:lipoyl(octanoyl) transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993:SF7">
        <property type="entry name" value="LIPOYLTRANSFERASE 2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993">
        <property type="entry name" value="OCTANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="2">
        <location>
            <begin position="113"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="467" mass="52810" checksum="B49FB38AE640C85B" modified="2011-10-19" version="1">MRLRHIHLPSRYSHWPPYSLACRVQSYLRRALLDWKDIPSVAPSKPAPPPDPSPESEEVSLPPPPDGLTPESAPAWEQLITSAEEEYRLKAQQKAERLKPKPKPWPEVHGKPPPPPPTVISFTPRPVYTLGRRQHDTPLSLDEVQRLKQPLFCPPWTVNPKQHGNPAWEVPDIVRVPRGGLMTYHGPGQIVLWPVMDLKGPGHSHFTVRCYARLLENTTIGLLKKLWDVEAITTEDPGVWVKSPRFVSGRPRVDGSRPELAKIAALGVHLRRNVTGLGTALNVRFWSARDISRHLRTTLNQHPPSDQPVDLNLLYDPWSRFTPCGLENKAVTSLRGTLYPPDTIRAGLLKGGYDTAADHAERNVAIAWCDEFAMRIGLPDINVETVDMQEVVRMLGFLVGEAEEKLEKGDWMGAVPVEGMGEEGWDEEKVKEMVERERRYVTRFEGIYLGRGWLPDEAPRTPKVMYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZF9</accession>
    <name>G0RZF9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0002820</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690829.1">
        <property type="nucleotide sequence ID" value="XM_006690766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZF9"/>
    <dbReference type="GeneID" id="18254320"/>
    <dbReference type="KEGG" id="cthr:CTHT_0002820"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_25_1_1"/>
    <dbReference type="OrthoDB" id="648285at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000119">
        <property type="entry name" value="MFS monosaccharide transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF73">
        <property type="entry name" value="METABOLITE TRANSPORT PROTEIN YDL199C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="509"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="572"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="167"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="25"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="96"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="632"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS23587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="801" mass="90427" checksum="0DEEA7F73B272AED" modified="2011-10-19" version="1">MTLSAADPDPRRLPSNIPLRTIPLQGEYSRQYSQQQQYQYSYHQQQPDDDDLSSLGSWTDTGDIGDQHADDDDPVRKHLEEQGALSDQILVGVLKRQHNRARSRSSSPSSGSRSSSQDRASLRKDRIRIPTVAHREVPWAERLLAAFMMGRSKGIHGLTGKPLLYFTSIFVSLGVFLFGYDQGVMSGIITGEYFKEYFHDPTSAEIATMVAILEIGALISSLLVGRIGDIIGRRKTILYGSCIFFVGGVLQTFAHSMGMMMIGRVLAGVGVGMLSTIVPVYQSEISPPHNRGHLACIEFSGNIIGYTTSVWVDYFCWFIKGNLSWRLPLFMQCIMGALLAAGSLIIVESPRWLLDNDHDEEGMVVIANLYGGGDIHNPRARDEFREIKLDVLLQRQEGERTYRDMFRRYGKRVFIAMSAQALAQFNGINVISYYAPLVFEQAGWRGHDAILMTGINGITYFLSTIPPWYIVDRWGRRPILLSGAVAMAIALVLISYFMHLNISSTPKIVVLLVVIYNAAFGYSWGPVPWLYPPEILPLKIRSKGASLSTATNWACNWLVGQMTPILQDWITWRLYLIHAFSCIVSLVVVYFLYPETRGVRLEEMDALFGDENRTQSSGESDALLRPGSSDGIGLSHGNDDSKYSASHSGGGRRSVFKAMPDKLELIHAYRKLLRAGLRAVQFSQPSRWSLTQQLRAGFRDPNGKFEPERIRRTIWFFNAAAQQRGIEHRILKNLCRVHWERFSPTRTPTWKSVLKQQEMKAKQEEKMKGAKGRDDVISGTEYEHYERTIAMLNDTMHLCLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0T0</accession>
    <name>G0S0T0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0011120</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691632.1">
        <property type="nucleotide sequence ID" value="XM_006691569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0T0"/>
    <dbReference type="GeneID" id="18255150"/>
    <dbReference type="KEGG" id="cthr:CTHT_0011120"/>
    <dbReference type="HOGENOM" id="CLU_1147086_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="242" mass="29305" checksum="BC763FEACD1DB3FC" modified="2011-10-19" version="1">MPYSPAPVIRYRPHFSSTVPPDNVIIYFEEPDFKPWEIRKSILVQHETYHRQNHKSRYLETIYRDVRLLRRLTQAFAEQVGKLTKRLWLLHILPPLIAFHLLLILTYYINPSHTPELESSSISFFSSSKQQFQTLYYLYYVILSLSFVPCVYASLSLLKSYEWHRQLKMIEKLNGELTMLEDHKASWHKPLPDTLLLKNERFYKAIYWNILEPYENWYFYGVDYDYVEMYRKAIRRDSNSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G0S113</accession>
    <name>G0S113_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL45</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L45, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0011970</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrion-specific ribosomal protein mL45 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691715.1">
        <property type="nucleotide sequence ID" value="XM_006691652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S113"/>
    <dbReference type="GeneID" id="18255235"/>
    <dbReference type="KEGG" id="cthr:CTHT_0011970"/>
    <dbReference type="eggNOG" id="ENOG502SAX9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055139_2_1_1"/>
    <dbReference type="OMA" id="WRIWGTT"/>
    <dbReference type="OrthoDB" id="19619at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051975">
        <property type="entry name" value="mtLSU_mL45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007379">
        <property type="entry name" value="Tim44-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28554">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L45, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28554:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04280">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tim44-like" evidence="9">
        <location>
            <begin position="149"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS22723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="309" mass="34450" checksum="8DD0B3146CE877FE" modified="2011-10-19" version="1">MVSPARFGLTARGLLSTRTTGSARITLGTAKWTSPAGQQCRWKGVATHRTAHGTDMNSQRSPAVEMQRKLGKGTNLAAEITSMVLPGTFVLPPLSQFPKPFSQKVKLLWYWLLIKGQEILTNAAVKYTSKPSFFKRAIYKPKRSVLIPTAKAMHRAMAEALASGDRDTINKICSRSLGTSLLASIDTRPKTRRYGWQLLDYTKKLFYPSVKSHRITALGREKNAPIVRQAVVSISSRQRRVQYDAQGKVIPGSEKEIDVVEHVAMACVVDPRTWAESEWRLVGTISATTLEEWDAEKEILKELMKNPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0S165</accession>
    <name>G0S165_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0012500</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691767.1">
        <property type="nucleotide sequence ID" value="XM_006691704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S165"/>
    <dbReference type="STRING" id="759272.G0S165"/>
    <dbReference type="GeneID" id="18255288"/>
    <dbReference type="KEGG" id="cthr:CTHT_0012500"/>
    <dbReference type="eggNOG" id="KOG1211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_14_2_1"/>
    <dbReference type="OMA" id="CGGDTMN"/>
    <dbReference type="OrthoDB" id="566138at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF5">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408819" description="Amidase domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="52"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="500" mass="53079" checksum="138E575445C4BB7C" modified="2011-10-19" version="1">MLPGIFIQALTVLLPLRTAAYTLNDDTFDPRTATTKDIHHTLFTNQTTCRGIISSFLARIEAFNPVINAIISLNPDSLSVADHLDAVLSSSSNITSLTTSFPLFCVPVLLKDNFDFVPLPTTAGSRALALNFPSEDAPSVQALSSAGAVILGKTNMHDMALEGLTVSSFAGQTRNPYDLSRTPGGSSGGSGAAVAAGFAVLAMGTDTMNSVRSPASAGGLVGVRPSRGAVSRRGVVPVSWRQDAVGIMGRSVEDVGVGLRTLMGVGVDPQDNATWEVPGKVWERDSGREIEREGKRGVRGRRFGLLTEGYFNFTTSAETDPVNGAMRNMVSKLTAAGAAVINISDPLLNPISLKSLDVQIFEYPPMLTSYLSLTASHNPPGSVPPSFRALYTQARPNRAFLVLPAQSSFLHAALKSSPSSEEYHSRLQGISRLREHLLSVFKAHDLDALIYPEQQNLVVPIGSPNQYGRNGLLAALTGFPVVCVPVGFSPPTDLAPAEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1D0</accession>
    <name>G0S1D0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative WD repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0013160</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691832.1">
        <property type="nucleotide sequence ID" value="XM_006691769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1D0"/>
    <dbReference type="STRING" id="759272.G0S1D0"/>
    <dbReference type="GeneID" id="18255354"/>
    <dbReference type="KEGG" id="cthr:CTHT_0013160"/>
    <dbReference type="eggNOG" id="KOG0266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014280_1_1_1"/>
    <dbReference type="OMA" id="FGQWTIT"/>
    <dbReference type="OrthoDB" id="63070at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000733">
        <property type="entry name" value="WD40 repeat-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051859">
        <property type="entry name" value="DCAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847:SF7">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="380"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="427"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="33"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS22840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="660" mass="74539" checksum="71A41F6F41616D48" modified="2011-10-19" version="1">MSSTHSSSGQSGHNEDSPHNSTNLYNWQHDPREDEEEGESENEENEDEEDEDYDDDDNDDDDDDDDDGLFPGNFEFELLIEEIPAGSDQADGSNGDEEGTSSGHRRTTIRIGPGIAGRSHLTQREFLAILRGQHLHPVVVYDENGRERVTFRIGNPNDVKRYPKVPNDEGRKLMESGAFGYFDRRGPEKKALARRLLDRELGIYSPERRRLNQGLMAQSMVPSSKPDMVIHYDDPVCCGQFSDDGNFFYACVKDFKVRLYDTSSPYNWKHYKTVRYPGGQWTMTDADLSPDNKWLAFSSLQSHVGISPTDPHDAGEPYTLDLADSSGLSNGSHDDPQYAFGSFPIFSVRFSRDGRQLVAGTGARSIVVYDIEARRSLFHVRGHADDVNAVCFADKYSPHILYSGSDDCTIKVWDTRSIGEGREAGAFVGHTEGLTYIDSKGDGRYILSNAKDQTLKLWDLRMAMSATRFAELDPTSVTRNRDYEYDYRWQEYEEYQWFPHPHDNSLVTFRGHRVQRTLIRCHFSPPNSTDSRYVYAGSYDGHVYVWNMDATLAAKIDVRSTTRPPAGLRHRPERRFRLGAFFHRRPDSWEALVRDVAWHPNAPIVVASSWSGSSMDCGTASLHSFNDGFAAEDDEGDPPMGFAVDEHLESFAAASSSGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1T9</accession>
    <name>G0S1T9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Lipoyl synthase, mitochondrial</fullName>
            <ecNumber evidence="10">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Lipoate synthase</fullName>
            <shortName evidence="10">LS</shortName>
            <shortName evidence="10">Lip-syn</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Lipoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0014790</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine + 4 H(+) = [[Fe-S] cluster scaffold protein] + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 5'-deoxyadenosine + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="10"/>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691991.1">
        <property type="nucleotide sequence ID" value="XM_006691928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1T9"/>
    <dbReference type="STRING" id="759272.G0S1T9"/>
    <dbReference type="GeneID" id="18255517"/>
    <dbReference type="KEGG" id="cthr:CTHT_0014790"/>
    <dbReference type="eggNOG" id="KOG2672">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033144_0_1_1"/>
    <dbReference type="OMA" id="PYCDIDF"/>
    <dbReference type="OrthoDB" id="3231at2759"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000036">
        <property type="entry name" value="Lipoyl synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031691">
        <property type="entry name" value="LIAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004019">
        <property type="entry name" value="PRK05481.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009544">
        <property type="entry name" value="PRK12928.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="LIPOYL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949:SF0">
        <property type="entry name" value="LIPOYL SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16881">
        <property type="entry name" value="LIAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01058">
        <property type="entry name" value="lipoyl_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="165"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="36"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="399"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS22999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="438" mass="47740" checksum="EEC078E66215903D" modified="2011-10-19" version="1">MASSAPIQRIQAPLRLCVARVGILSFRGYATIPSVSDVQQQQPSPPAEAASPSATSTSTDAASSSTPKTRPTYFKDKVIAPFSDFLPSSISEAAATYTPRTATVGPEGRKRTITRLPDWLKTPIPSAGTNPSFAKIKSDLRGLNLHTVCEEARCPNIGECWGGSKDGRAAATATIMLMGDTCTRGCRFCSVKTSRRPPPLDPNEPENTAEALARWGLGYVVLTSVDRDDLADGGAHHFAETIRRIKAKKPGMLVEALTGDFAGNLDMVRIVAESGLDVYAHNVETVEGLTPYVRDRRATFRQSLKVLEHAKAVRGKGSLITKTSLMLGLGETEEEIWETLRELRKIDVDVVTFGQYMQPTKRHLKVERYVTPAEFELWRQRALDMGFLYCASGPLVRSSYKAGEAFIENVLRRRAAEKAVPPETLSQAVAVEDASKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1U1</accession>
    <name>G0S1U1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nicotinate-nucleotide pyrophosphorylase [carboxylating]</fullName>
            <ecNumber evidence="10">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">CTHT_0014810</name>
    </gene>
    <organism evidence="30">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>nicotinate beta-D-ribonucleotide + CO2 + diphosphate = quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12733"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Hexamer formed by 3 homodimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NadC/ModD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the C-terminal section; belongs to the NAGSA dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the N-terminal section; belongs to the acetylglutamate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="10"/>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS23001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691993.1">
        <property type="nucleotide sequence ID" value="XM_006691930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1U1"/>
    <dbReference type="STRING" id="759272.G0S1U1"/>
    <dbReference type="GeneID" id="18255519"/>
    <dbReference type="KEGG" id="cthr:CTHT_0014810"/>
    <dbReference type="eggNOG" id="KOG2436">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3008">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4354">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006384_4_0_1"/>
    <dbReference type="OMA" id="IAFIPHV"/>
    <dbReference type="OrthoDB" id="438291at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00107"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04252">
        <property type="entry name" value="AAK_NAGK-fArgBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23936">
        <property type="entry name" value="AGPR_C_ARG5_6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd24149">
        <property type="entry name" value="AGPR_N_ARG5_6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04263">
        <property type="entry name" value="DUF619-NAGK-FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000019">
        <property type="entry name" value="Bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000029">
        <property type="entry name" value="Bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000011">
        <property type="entry name" value="N-acetyl-gamma-glutamyl-phosphate reductase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000090">
        <property type="entry name" value="Nicotinate-nucleotide pyrophosphorylase [carboxylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.20:FF:000003">
        <property type="entry name" value="Nicotinate-nucleotide pyrophosphorylase [carboxylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="entry name" value="Quinolinate phosphoribosyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00150">
        <property type="entry name" value="ArgC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023013">
        <property type="entry name" value="AGPR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058924">
        <property type="entry name" value="AGPR_dimerisation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041734">
        <property type="entry name" value="NAGK-fArgBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006855">
        <property type="entry name" value="Vertebrate-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342:SF0">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04768">
        <property type="entry name" value="NAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22698">
        <property type="entry name" value="Semialdhyde_dhC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01224">
        <property type="entry name" value="ARGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51731">
        <property type="entry name" value="GNAT_NAGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="18" id="KW-0418">Kinase</keyword>
    <keyword evidence="23" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="24" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="20" id="KW-0521">NADP</keyword>
    <keyword evidence="17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0808">Transferase</keyword>
    <keyword evidence="21" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="28">
        <location>
            <begin position="338"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="active site" evidence="27">
        <location>
            <position position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00007239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00011218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00011944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00020990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00033102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00047445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="EGS23001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1194" mass="130844" checksum="FB6C466E343948B9" modified="2011-10-19" version="1">MLSAAAVSLRAGARRTVRRLPIRARAVAVPAYLRRQRPFSTSAARPTDLSTRSMIIQTLSSVGSKREVQQYLSLFTSVSSQRFAVIKVGGAILTDYLDELCSSLAFLYTVGLYPVIVHGAGPQLNKLLEEAGVEPQFEEGIRVTDAKTLRVARDLFLQENLKLVNKLEEKGVHAQPLTTGIFRAGYLNKDKWGFVGKVTSVNKAPIEAAINNGYLPILTSMAETDDGQILNVNADVAASELARALEPLKVVYLSEKGGLFDAAGQRISAINLDEEYDYLMSQEWVKYGTRLKIKEIKELLDTLPRASSVAIIHPGELQKELFTDSGAGTLIRRGNKLVSATSLSDFKDLDALKQVLIRDREGPDAMATVDKYLEFLKENEFKAFFDGPMNALAIVLPASNGRHATLSTLTITKSGWLTNVADNIFTALRKEYPSLVWTVREDDENLGWFFDKADGSVTRNGAVMFWYGIENGDEIVKLMKDFTQNGRAMLGDSNLESRLYRAYKQAAGAAAQQTRSYSTFVHRPVLSAPVFGQTARRGYVTQTNPNPPYGKKNASNDKPARVALIGARGYTGQELVRLLDTHPHMELTHVSSRELAGKKLEGYNKSEVIYSNLSPEDVRDMERRGEIDCWVMALPNGVCKPFVEAVWEGRKDSNHKSVIIDLSADYRFDNTWTYGLPELVPRANIAQATQIANPGCYATAAQLGIAPLVPHLGGMPHVFGVSGYSGAGTKPSPKNDVNLLTDNIMPYSLTGHIHEREVSTQLGAQIAFMPHVAVWFRGIHHTISIPLNKTMTSRDIRQIYQDRYAGEKLVKVVGEAPLVKFISGKHGVEIGGFEVDSTGKRVVVCATIDNLLKGAATQCLQNMNLALGYAEYEGIPDKANAPLPKHNIMFDLPLEHGSLEHLLPVSWKTQITAWLAEDTPSFDVGGFVVGDAPRTATLWGKSPGILAGVPFFNEVFRQCGCTVEWHAREGSHIETHGGKTALATVRGPARGLLEGERVALNILARCSGIATMSRRLLVNLRSAGWKGMLAGTRKTTPGFRLVEKYGMLVGGADTHRMDLSTMTMLKDNHIWSRGSITQAVKAAKAAGGFSLKIEVEVQSEEEADEAIAAGADVIMLDNFTPEGVRAASKSLKEKWKGKREFLLEISGGLTEDNAEQYICNDIDILSTSAIHQGVRHIDFSLKINVDKSGPEVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1U3</accession>
    <name>G0S1U3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">THIF-type NAD/FAD binding fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0014830</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the ATP-dependent dehydration of threonylcarbamoyladenosine at position 37 (t(6)A37) to form cyclic t(6)A37 (ct(6)A37) in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HesA/MoeB/ThiF family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS23003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691995.1">
        <property type="nucleotide sequence ID" value="XM_006691932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1U3"/>
    <dbReference type="STRING" id="759272.G0S1U3"/>
    <dbReference type="GeneID" id="18255521"/>
    <dbReference type="KEGG" id="cthr:CTHT_0014830"/>
    <dbReference type="eggNOG" id="KOG2018">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013325_9_3_1"/>
    <dbReference type="OMA" id="GSWVVTM"/>
    <dbReference type="OrthoDB" id="10265862at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061503">
        <property type="term" value="F:tRNA threonylcarbamoyladenosine dehydratase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061504">
        <property type="term" value="P:cyclic threonylcarbamoyladenosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00755">
        <property type="entry name" value="YgdL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000125">
        <property type="entry name" value="tRNA threonylcarbamoyladenosine dehydratase 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267">
        <property type="entry name" value="TRNA THREONYLCARBAMOYLADENOSINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267:SF2">
        <property type="entry name" value="TRNA THREONYLCARBAMOYLADENOSINE DEHYDRATASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="13">
        <location>
            <begin position="103"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="39"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS23003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="532" mass="58570" checksum="D5EAB8C963AE16F6" modified="2011-10-19" version="1">MSSLSSNPKLQLAATAVVSAALAAGAILSYQHLQQFKQPHSSRRRYSIPNLPSNGNGDPALQPVTRMGPLPKPDPEDEHNQVLAHRAQNGDWDDELILEQLARNRVFLGDEGLVKLRNAFVIVVGCGGVGSHACAALARSGVSKIRLIDFDQVTLSSLNRHAVATLADVGLPKVQCLQRRLIAITPWVKFDLRLQKFDASVAVDLLEGWKGDPAQKPDFVIDAIDNIDSKVELLKFCHDNGLPVISSMGAGTKSDPTRVMVGDISASFEDALSRATRRKLKLKGVTSGIPVVYSTEKMGPGKAALLPLPEEEFQKGAVSDLSVLPDFRVRILPVLGTMPAVFGYTVANHVILSITGKLYNFEDPAYLSPSVTDFCLGYPMDYQPAKARDKMYESILAYVQASEEKIVRMIEGGRTDVCIGLKVPITPGDIAFLVEEAFRGRSAVSGIPTKLMLIRWKKPEKTTLIRIGEGKDEQKSSNLRLRDLVCMTKEEAVRHLNEVLLGNKNLEELYDKEVIEKVEARQKEAEEYEKHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>G0S212</accession>
    <name>G0S212_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dedicator of cytokinesis protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0015580</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DOCK family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS23072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692064.1">
        <property type="nucleotide sequence ID" value="XM_006692001.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S212"/>
    <dbReference type="GeneID" id="18255596"/>
    <dbReference type="KEGG" id="cthr:CTHT_0015580"/>
    <dbReference type="eggNOG" id="KOG1998">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000595_0_1_1"/>
    <dbReference type="OMA" id="LWDNQAF"/>
    <dbReference type="OrthoDB" id="18896at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08679">
        <property type="entry name" value="C2_DOCK180_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11684">
        <property type="entry name" value="DHR2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.350">
        <property type="entry name" value="Dedicator of cytokinesis N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032376">
        <property type="entry name" value="DOCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042455">
        <property type="entry name" value="DOCK_N_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056372">
        <property type="entry name" value="TPR_DOCK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653:SF10">
        <property type="entry name" value="MYOBLAST CITY, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16172">
        <property type="entry name" value="DOCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23554">
        <property type="entry name" value="TPR_DOCK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="7"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="C2 DOCK-type" evidence="9">
        <location>
            <begin position="605"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="DOCKER" evidence="10">
        <location>
            <begin position="1412"/>
            <end position="1827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="89"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="439"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1832"/>
            <end position="1876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1894"/>
            <end position="1918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1971"/>
            <end position="2007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2047"/>
            <end position="2078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1832"/>
            <end position="1861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1894"/>
            <end position="1904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1971"/>
            <end position="1986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="2063"/>
            <end position="2078"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS23072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2104" mass="232055" checksum="8C927344F5FD99F7" modified="2011-10-19" version="1">MPWQPLPRIAFAVAIYPFAAQGPQDLPLELGDELYIIEETSDGNWLRGYLVAPPSLLAGLTSVKGQTLEARVFSGIFPRSCVEIREVLGESDESDESDANSSSLTDEDGAAPEPGERGVENKRRKAGSRKGGRSTSPGLLSVPVRRDPNAPRPPAPVPMLKIGDETPTSASEPLIDEIASCLREWHSTNLHELLLSRQYSKLDTLSHLITSLNLARQQFLHDVLTSWEYEKLREKTVWDLVKVNKLCGGEVIVRDPNARGRVLTGDDSVIEVTKLQSIMSLLEEPPTQPVELTALHHLLVDIKGFAGASTEATTLVLYLAIKPPGGTLKPLSECYIVEMPAGGQMGHLARNAQMRTLFTDLTAAEIGDVPANEPELFLIVKIRASQQVVAVKPSSRSGSISQALPQFAKDHKPPLSAGAKSVRRSLMWAGKTTRSAFSRGNARLDSLSEQPEETVGSPHTAGAESRDGMPPGTANSKSGGGGRTSVDGHVAQATADRTVGVGILKLNSVMKQADEVEHIVTIWSPSVRVPERNEAGEEWDPIIRDLLESKTGHYEKSRRAERVQVHLRAFNHPDADALIKATPTMLAGVCKTNKMGFAGAPTKPRSDIYLTLDEAVLSRQTLLSRAGGSPTSLPNAVHGTNLQLTLEVRRSTGERVESCIYPSSNAEPASAWKTVVTERGEKWRQTIRLSLSPSDVSQSHVVLHLADAPNPPFAIAFMPLWDRQAFIHDGAHSLLLYRLDENTSNAQPGSQGRGGYLSLPFAAAEDKRHHHGPGSEGSGPLAMVRVDTYLCSTRFSQDRVVLGLLAWKESSREGIPHLLKQFIFVPEIEVVKLLNDVLDALFGILVEYSGNDDYEDLVFTALVRVLDIVHDRRFNLAPLVDQYAETRFNYPFATLCLVRSFIRLLSKPTEPETARKLRSTFKVARHILKFITHARSQQKAKEAGIGITGPNAGFTRHLRTIFKALDSMMRSSAPVLIGSQTLAVQHFHTWLPELTGLLSTEEILHIAIDFMDSCSKVKGKLILFKLVLIINYARLDIFSGAEQRSALSANTVRWIAPHWGYTDEVTDQWRDQVRLCCSVLASQMDHLGPEIPDYIPKIIGKPISEPAIFDEALIELSAILSALSSSPSGMQLELAEDDLHVIVEKCLRVHMSILQGEAFPQNWLSVHIYHHKSAMRVLQYLASILLDSFLPHPDEAESFNTELWKLFFTTLLKLVGSPSLALETFPEQKRRAVWKIAGDVREHGADLLRKTWEAIGWETTVEERARFGLSKLGGYQVQYVPTLVAPIVELCLSVHEGLRRMAVEVLQTMIVSEWTLSEDLSVIQTEMIDCLDAYFKAKPLTESILQKLFIGELLERFEPLRKVDSEDPLYKSLRELTDTVDEFLDLLVAVHSGDGSGEATHLIHRLRLMEFLRDMQKEEIFIRYVHQLANLQAQARNHTEAGLALRLHADLYDWDPLKTTPALHEPEFPAQSHFERKERIYFDMIKHFEDGEAWSSALAAYKELQTQYETNVFDFAKLARTERAIASIYEHIVKSDKLVPKYFKVVFKGLGFPPSVRDKEFVFEGSPNERTASFTDRMQEMYPAARIVTTEHIDDLEGQFLVISMLSPHRDPSHQVYQRARVPQIIRDYLLSANPQTFSVTVRRVTAGPVHEHFTDKLVYTTAEPFPTILRRSEVVSVREVRLSAGETALERIVRKTAEMSSLEKKIADGEAGEDAAQLLLDAVAISVNPGSESSVAAYRQLLPGAKERTSGSEQFDLEDLEQAPELSPQENAIKMALVDHAIMLKRCLATVAKFGSEQLSKRVEELQRYFETTYAPEIALFTPAPAIMSSSTAGLTSGTLRSSPSMSYPQQFQQQPTQQPKNGTSSSPTPEHKPAQSISFLHGRAPRLSFLHSSRKKEHHHQRSATATNGADMKHPLYETEGNDTVVSLGAAKSVTSSVTGASTAKEGASTGHHGNRRSFFKVTSVPNLTGSSSGQGNTNHNMNGDGSHHHRITAQPSSNVGSGVAAGMGVTNEWVTDAGTSSVAGTASFEHHRNYGMAEKDGAVVTTSNPVSSSGEGQTHGHGHGHHHHGSSIGSVRKRLSLLRLGKKSSRGAGMLGGVDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0S256</accession>
    <name>G0S256_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase II subunit RPB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0016050</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS23116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692108.1">
        <property type="nucleotide sequence ID" value="XM_006692045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S256"/>
    <dbReference type="STRING" id="759272.G0S256"/>
    <dbReference type="GeneID" id="18255643"/>
    <dbReference type="KEGG" id="cthr:CTHT_0016050"/>
    <dbReference type="eggNOG" id="KOG1522">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038421_1_1_1"/>
    <dbReference type="OMA" id="FYFEVES"/>
    <dbReference type="OrthoDB" id="270173at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07031">
        <property type="entry name" value="RNAP_II_RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.120.12:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="9">
        <location>
            <begin position="28"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="312"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00072506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS23116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="344" mass="37018" checksum="70096F103F1C8FF3" modified="2011-10-19" version="1">MMDYDPMVMDDAESLGPAVKISQADSTRVKFELSNADLSFANSLRRVMLAEIPTIAIDLVEIEVNTSVLADEFIAHRLGLIPLNAEGVDQLLYSRDCDCDGYCEQCSVRLSLHAKCTGDENMHVFSRDLVPVGERVNQNLGTPIINDPDGLGPLILKLRPGQEIKLECIAKKGIAKEHAKWAPSAAIGFEYDPHNKLHHLDLWYEQDPKAEWPPSEYAEWEEPPQEGEPFDYDAVPNRFYFNVESAGPLPPDAIVQEGIKVLQQKLAGLIHELTEGDSGGANGDYRGPRSPGGGFGAGGGTDGFGGGYTTPFGNGGNQSSWGGAAGGTTPYGQTPYGVGAGGWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G0S263</accession>
    <name>G0S263_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Polynucleotide 5'-hydroxyl-kinase GRC3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Polynucleotide 5'-hydroxyl-kinase grc3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0016120</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="16 17 18" key="2">
        <citation type="journal article" date="2019" name="Nat. Struct. Mol. Biol." volume="26" first="830" last="839">
            <title>Cryo-EM reveals active site coordination within a multienzyme pre-rRNA processing complex.</title>
            <authorList>
                <person name="Pillon M.C."/>
                <person name="Hsu A.L."/>
                <person name="Krahn J.M."/>
                <person name="Williams J.G."/>
                <person name="Goslen K.H."/>
                <person name="Sobhany M."/>
                <person name="Borgnia M.J."/>
                <person name="Stanley R.E."/>
            </authorList>
            <dbReference type="PubMed" id="31488907"/>
            <dbReference type="DOI" id="10.1038/s41594-019-0289-8"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.90 ANGSTROMS) OF 110-748 IN COMPLEX WITH MG(2+)</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e57984" last="e57984">
            <title>Structural insights into coordinating 5S RNP rotation with ITS2 pre-RNA processing during ribosome formation.</title>
            <authorList>
                <person name="Thoms M."/>
                <person name="Lau B."/>
                <person name="Cheng J."/>
                <person name="Fromm L."/>
                <person name="Denk T."/>
                <person name="Kellner N."/>
                <person name="Flemming D."/>
                <person name="Fischer P."/>
                <person name="Falquet L."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="37921038"/>
            <dbReference type="DOI" id="10.15252/embr.202357984"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.01 ANGSTROMS)</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Polynucleotide 5'-kinase involved in rRNA processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Clp1 family. NOL9/GRC3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692115.1">
        <property type="nucleotide sequence ID" value="XM_006692052.1"/>
    </dbReference>
    <dbReference type="PDB" id="6OF2">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="B/E=110-748"/>
    </dbReference>
    <dbReference type="PDB" id="6OF3">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="B/E=110-748"/>
    </dbReference>
    <dbReference type="PDB" id="6OF4">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="B/E=110-748"/>
    </dbReference>
    <dbReference type="PDB" id="8PUW">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.01 A"/>
        <property type="chains" value="B/E=1-748"/>
    </dbReference>
    <dbReference type="PDBsum" id="6OF2"/>
    <dbReference type="PDBsum" id="6OF3"/>
    <dbReference type="PDBsum" id="6OF4"/>
    <dbReference type="AlphaFoldDB" id="G0S263"/>
    <dbReference type="EMDB" id="EMD-17949"/>
    <dbReference type="EMDB" id="EMD-20040"/>
    <dbReference type="EMDB" id="EMD-20041"/>
    <dbReference type="EMDB" id="EMD-20042"/>
    <dbReference type="SMR" id="G0S263"/>
    <dbReference type="STRING" id="759272.G0S263"/>
    <dbReference type="GeneID" id="18255650"/>
    <dbReference type="KEGG" id="cthr:CTHT_0016120"/>
    <dbReference type="eggNOG" id="KOG2750">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010345_1_0_1"/>
    <dbReference type="OMA" id="PEFAPMG"/>
    <dbReference type="OrthoDB" id="4054781at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000448">
        <property type="term" value="P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001156">
        <property type="entry name" value="Polynucleotide 5-hydroxyl-kinase grc3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF3">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-HYDROXYL-KINASE NOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="16 17 18" id="KW-0002">3D-structure</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Clp1 P-loop" evidence="13">
        <location>
            <begin position="268"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="40"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="570"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="692"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="570"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="588"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="699"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16 17">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS22096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="6OF2"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PDB" id="6OF3"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PDB" id="6OF4"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="19">
        <source>
            <dbReference type="PDB" id="8PUW"/>
        </source>
    </evidence>
    <sequence length="748" mass="81338" checksum="14EE3E2249485144" modified="2011-10-19" version="1">MTSTKKRKLEGSASESGNNTPILSAFAARQQLWAQSLVVQAQKQPQSVDNSKHVTERRSATPISAAQVLRKSKRKSPEDSPITPATPATPVETEEEKPSKPSSPRELLRHHSSFQPNNSNFQRKAGGRLVLSTPDVERFVILGNYGVKVHQGEVTIAGATLTPIDDVQWVHAPHCHALPVLRTANDTVIELLPCPTAQGLRELARLNPLFGRLWNETSDTFQIIYTSADAPKRTSLRELASHPAWNKKISELLTSTRRKPSPILFICGPKSSGKSTFGRLLTNRLMTDRAGHKSRSWKPVMVLDLDPGQPEFSPPGVVSLTKLRRPNLAPPFCHPGLSFGEKGLDGGNEGMTTVRMHAIASVTPALDPAHFIACARDLFAYYRRSASQENIPLVVNTPGWIQGTGLDLLAELIAVLRPTEVLYMSEDGPEETVSALREACASSSTIPFTMLPSQPNSSGEGGGGGAASWTPATLRSMAMQSYFHLSPFSRDQQGGPGCEWNPTPLTHLCPWRVRLAGRPDERGVLGIVCYDHQYAPELVSDAINGMVMGLVRIEKKEALRGLAVPGDTSLSFTSSTSQGGCDDELDSDSNSSSAPSFTSSSPSHLNSTPLLPLIPNPTGSPLSPQYTSLVGLVLIRGVSLTASNPELHLLTPVPPSVLHSFRGDELVLVAGKFDAPTWAYVEGLYWKSNSKAAKRVDEEREDEDREESGGVEEEEEQDEVPWVEMLHGSAGRDVGSRVWRVRRDLGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2C9</accession>
    <name>G0S2C9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0016790</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692181.1">
        <property type="nucleotide sequence ID" value="XM_006692118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2C9"/>
    <dbReference type="STRING" id="759272.G0S2C9"/>
    <dbReference type="GeneID" id="18255717"/>
    <dbReference type="KEGG" id="cthr:CTHT_0016790"/>
    <dbReference type="eggNOG" id="KOG0051">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_279006_0_0_1"/>
    <dbReference type="OMA" id="IYEMDEG"/>
    <dbReference type="OrthoDB" id="39591at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051651">
        <property type="entry name" value="DMTF1_DNA-bind_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46380">
        <property type="entry name" value="CYCLIN-D-BINDING MYB-LIKE TRANSCRIPTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46380:SF2">
        <property type="entry name" value="CYCLIN-D-BINDING MYB-LIKE TRANSCRIPTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="797"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="802"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="849"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1028"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="131"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="372"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="444"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="458"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="540"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="587"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="616"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="633"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="686"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1050"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1069"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1181"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1201"/>
            <end position="1214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS22162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1227" mass="138244" checksum="18214208DA5A0B73" modified="2011-10-19" version="1">MGNEQSRLEEGGSVSGGRARSISPLPRDDEYLGDGTDDLRQYPSTMPAGLTMGREPTRSPSPSRLSGSPEARRGKHRPRDHSPGTPPQRFAASQPAWSAHSPVDMEMSASQPELRKKKKKSRRSKGQSPVRKHESRVEDEQDHAPVDIDDGRHYEEAESHISPRPKKKHKRASIHVEEPEHEHEPEPIRDAVDPPESEEERSSGNNNNNKKKKKKKKQKRKSVSSLMDESVADQEDELLETQKNKRTSRRQDEVTAESPKHSSNHSDVDIPDADLSMVHTAGDEPASQAPPPSAQPLEKRSRRDSVSKALKKRKLSSLDDALEEDTSHLHEEELSVALEPPEYRPTTRPATSAAMQQKSKRVRSGPTAEQNIDVKQEINENGDELHSIPQSEQPEEEELLVAKEPPSSPESHRADLEEDINGIVGKEPSPELDDMSVAGSVVEQAHHSDREASVRKEEEEEEEGEEDAGSNRSEDEDAGIGNDGDDAASDQSEEREASVDREEEDDALSQSADREASAAREEEDTASNQSGGEAIVKQQDDDDSSQSADGEEQADEDADEAASNQSEELVSAAVALLDDTDNALPVSTPAARPARSPAPRSSTKRKPKQPFFVGQDDQEEREDVVMESEPEREEERQERQESEPQREEEQEEERQEPQQEENTRAFAELPVNVVEHPRQRKRKALQETNDSPVSTEQPKKKRKRAFQKTEDGTGNDESGRSQYRYGPLSEQEQNQVTRALQRFREDEQMEEEQLIKLIHENPLTGGPLHRELWASVQEACPSRPRQKLINWCRQKFHNYTARGTWTKEQDEELSQLVDKHGRKWSYIAGLINRHPSDVRDRWRNYLVCRDRKRSDYWSEDEEERFRKIVEDAIEAIKASQDPAQSDKSPEELINWLKISEAMGFTRSRLQCIDKWKRLRANEVAETKAPTVLPQGKSWRLEKARKDLRRMTVQDKYRLMCAIRDSGVGRETKINWKDIVDRVFDGQYERQALIVAWGRLRQAVPEWEWKTTRDCAKYMCEMYEREGNFGPADLDWPEAKEDDAASQASRRAAKRRKRAKSKAVARDSPEPEGGDAEAEEQARAEGEDGASGSQEHDGESIEVAATREQQAEPETEPEPELGSAQPSPSIDANAARLKRRANNKVYDRRSSLGGQAISDTTPSRGSERTRRESLANGHAGEVPSAKKAKTVVASVVAQQQADDGEISSDMDDMEDIPAQLPKAGQEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2H0</accession>
    <name>G0S2H0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0017200</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692222.1">
        <property type="nucleotide sequence ID" value="XM_006692159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2H0"/>
    <dbReference type="GeneID" id="18255758"/>
    <dbReference type="KEGG" id="cthr:CTHT_0017200"/>
    <dbReference type="eggNOG" id="ENOG502RJKT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_188547_3_1_1"/>
    <dbReference type="OMA" id="VAMAYPT"/>
    <dbReference type="OrthoDB" id="4835952at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408841" evidence="1">
        <location>
            <begin position="17"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="67" mass="7047" checksum="ABAD8D0597423CAA" modified="2011-10-19" version="1">MKFFAAVLAFAAVAVAYPSVPEHNAPVKRQNIVTNIDVSVPAMTDSQGNVVPFDATKVYLAAKANGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2S5</accession>
    <name>G0S2S5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent RNA helicase DHH1</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">ATP-dependent RNA helicase dhh1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CTHT_0018310</name>
    </gene>
    <organism evidence="23">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692327.1">
        <property type="nucleotide sequence ID" value="XM_006692264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2S5"/>
    <dbReference type="STRING" id="759272.G0S2S5"/>
    <dbReference type="GeneID" id="18255869"/>
    <dbReference type="KEGG" id="cthr:CTHT_0018310"/>
    <dbReference type="eggNOG" id="KOG0326">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_30_0_1"/>
    <dbReference type="OMA" id="TYEDRHT"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17940">
        <property type="entry name" value="DEADc_DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000114">
        <property type="entry name" value="ATP-dependent RNA helicase DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000364">
        <property type="entry name" value="ATP-dependent RNA helicase DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 17 22" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="5 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="21">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="73"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="253"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="426"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="436"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="458"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="498"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="513"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="532"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00040210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EGS22308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="554" mass="62687" checksum="CE69543CFE025838" modified="2011-10-19" version="1">MTDILIDKLRNSDADDDWKKGLNIPAKDTRTQTEDVTNTKGLEWEDFNLKRDLLKGIFEAGYEKPSPIQEESIPIALAGRDILARAKNGTGKTAAFVIPALEKINPKVSKIQCLILVPTRELAMQTSQVCKILGKHLGVNVMVTTGGTGLRDDIVRLQDAVHIVVGTPGRILDLASKQVADLSECPMFIMDEADKLLSPEFTPVIEQLLQFHPKDRQVMLFSATFPISVKAFSDNNMRDPYEINLMDELTLRGITQYYAYVEERQKVHCLNTLFSKLQINQSIIFCNSTNRVELLAKKITELGYSCFYSHAKMPQAARNRVFHDFRNGVCRNLVCSDLLTRGIDIQAVNVVINFDFPKNAETYLHRIGRSGRYGHLGLAINLINWDDRFNLYNIERELGTEIHPIPAEIPKNLYVYENPETIPRPISTFKPVPIGQKQLPMPQTSQQQQVPQQPQPQQPQQAQEQQKQAQQELQQQQAQPAAQQGQPRSGHQNDWHGQNRQGYQQNRNMHQGNRGGYGGSHRGGRGRGGYQNQGQRHQNYGAPQQRGPRQQQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0S319</accession>
    <name>G0S319_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3'(2'),5'-bisphosphate nucleotidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0019330</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692421.1">
        <property type="nucleotide sequence ID" value="XM_006692358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S319"/>
    <dbReference type="STRING" id="759272.G0S319"/>
    <dbReference type="GeneID" id="18255971"/>
    <dbReference type="KEGG" id="cthr:CTHT_0019330"/>
    <dbReference type="eggNOG" id="KOG1528">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033446_1_0_1"/>
    <dbReference type="OMA" id="RSENCTH"/>
    <dbReference type="OrthoDB" id="411145at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051090">
        <property type="entry name" value="Inositol_monoP_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200:SF2">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200">
        <property type="entry name" value="PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS22402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="441" mass="49100" checksum="E9D33428FF04D41A" modified="2011-10-19" version="1">MVLLDGQPSSSEYAAARNLAELAVERASLATKRVLATIPSLQDKIHPESPLSRYLKSQTPDRQCDGTWASLNKFLKDDKSVVTVADYAAQALLIAAIRASEKFKNDKIIAEESIERLRSDPEFRRRVFEVVESTKLDNWGEKALGGSSARPNNEEELLKLFEGLVPKRGPQTIRKGDRFWCMDPVDGTSRYLTGGQYAVMLALVDGEGEAVAAVGCPNLRLPASRRSFDIGDDDFVLDSNADLAGFGCLLSAERCQGARVRRMWPGTFEEKDLSRENLGSELLSRNLLPPPAADLSNVLFVDSPTSPASLSEKVKELCTRLNVSYPPEQNSGPYASHMRNVRAIFGGRNLVQVRWPKPGPKEIWDIHDHVGTQLIYRESGPGKVTDLRGKTFDFAKGQSRLTDNWGLVMADPSIHDTLIQKLEEMLNEEKEKKNPALRMFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0S320</accession>
    <name>G0S320_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pectate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0019340</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692422.1">
        <property type="nucleotide sequence ID" value="XM_006692359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S320"/>
    <dbReference type="SMR" id="G0S320"/>
    <dbReference type="STRING" id="759272.G0S320"/>
    <dbReference type="GeneID" id="18255972"/>
    <dbReference type="KEGG" id="cthr:CTHT_0019340"/>
    <dbReference type="eggNOG" id="ENOG502QR5B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021894_0_1_1"/>
    <dbReference type="OMA" id="ATWGVEG"/>
    <dbReference type="OrthoDB" id="1637350at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002022">
        <property type="entry name" value="Pec_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045032">
        <property type="entry name" value="PEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683">
        <property type="entry name" value="PECTATE LYASE 18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683:SF18">
        <property type="entry name" value="PECTATE LYASE 21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00544">
        <property type="entry name" value="Pectate_lyase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00656">
        <property type="entry name" value="Amb_all"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408785" description="Pectate lyase domain-containing protein" evidence="5">
        <location>
            <begin position="19"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Pectate lyase" evidence="6">
        <location>
            <begin position="47"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS22403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="336" mass="37191" checksum="6AE786703753BB9B" modified="2011-10-19" version="1">MRFRTLFFTLFVTHLAAAHPLEWLGLASWDVEGYAKDNPIGPTTGGEGGETVTVDNAADFKAAVTGNDPRIVLVIGEINLPSRLKIGANKSVIGFGKTAHITGSGLDVYHVSNVIIRNLKISFIKDNDCITIRNSTRVWVDHNEFESDISKGPDFYDGQVDVIRGSDWITVSWNYFHDHWKSSLVGNDAALRDEDFGKLHVTYHHNYWRNAGTRGPAGRFGHQHVYNNVYADFLYQAIHSRSYNQILVEGNVFRGNTREALSTYGLVIPEDSPNTCSCGDEELDGFANLGAKNDWGEAGVNITQVGNFTKAPYKFKLTPLSLVERVVKLGVGIGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0S391</accession>
    <name>G0S391_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutathione S-transferase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0020140</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692493.1">
        <property type="nucleotide sequence ID" value="XM_006692430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S391"/>
    <dbReference type="STRING" id="759272.G0S391"/>
    <dbReference type="GeneID" id="18256052"/>
    <dbReference type="KEGG" id="cthr:CTHT_0020140"/>
    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_3_2_1"/>
    <dbReference type="OMA" id="WICYAQG"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03044">
        <property type="entry name" value="GST_N_EF1Bgamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000148">
        <property type="entry name" value="Elongation factor 1B gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050802">
        <property type="entry name" value="EF-GSTs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986:SF10">
        <property type="entry name" value="ELONGATION FACTOR EEF-1B GAMMA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="3"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="92"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS22474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="24344" checksum="669F624D2CB8A556" modified="2011-10-19" version="1">MAPFGKIYSYPGNYRVARTLALAELNGLEVVLDPDFQMGVTNKTPEFLAKFPLGKVPAFESADGSFHLTEGQAIARYVADSGPKAAQLLGADPKTRALIDQWACFAEQELGMHLLLPVRMTLFKIIPFDEARYDQCAANFERALKRLDVALQGGKKFLVGDQLTFADVMVLGPLSLATKVLVDAEMRKAAPNVEGYLKGLLEIPELKKAFGELVLIETRVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3A5</accession>
    <name>G0S3A5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">laccase</fullName>
            <ecNumber evidence="5">1.10.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CTHT_0020300</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Lignin degradation and detoxification of lignin-derived products.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="5"/>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692507.1">
        <property type="nucleotide sequence ID" value="XM_006692444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3A5"/>
    <dbReference type="SMR" id="G0S3A5"/>
    <dbReference type="STRING" id="759272.G0S3A5"/>
    <dbReference type="GeneID" id="18256068"/>
    <dbReference type="KEGG" id="cthr:CTHT_0020300"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006504_3_2_1"/>
    <dbReference type="OMA" id="HNGTGIH"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13854">
        <property type="entry name" value="CuRO_1_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13880">
        <property type="entry name" value="CuRO_2_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000021">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000078">
        <property type="entry name" value="Laccase-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000046">
        <property type="entry name" value="Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF87">
        <property type="entry name" value="LACCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409268" description="laccase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="16">
        <location>
            <begin position="83"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="14">
        <location>
            <begin position="205"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="424"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGS22488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="607" mass="67622" checksum="3D7FB12DEC090292" modified="2011-10-19" version="1">MKFLTYATTLLGTLTAVVGAVPTRSGTKNKYIRDGPGPCHTPSNRACWASGFDIYTDYEVNTPNTGVTRKYTLTLTEEDNWTGPDGVVKEKIMLVNGKIMGPTIEANWGDWIEVNVINNLLTNGTSIHWHGIHQKGSNLHDGANGVTECPIPPNGGQRTYRFRAQQYGTSWYHSHFSAQYGNGIVGPIVIHGPASLPYDIDLGPFPLVDYYYKSADELVHHTQSNGPPFSDNVLFNGTGVHPQTGHGQYAKVTLTPGKRHRLRIINMSTENHFQVSLVGHQFTVIAADMVPVHSYNTDSLFLAVGQRYDVIIDASPTPGNYWFNVTFGGGFACGGSLNPHPAAIFHYEGAPDALPTNPGVTPRDHNCLDTLDLVPVVPRNVQVNQFVKKPENTLPVELSIGGTPLFVWKVNGSAIDVDWGNPVLQYVMDGNTSYRQADNIVEVNGVNQWTYWLIENDPNGAFSLPHPMHLHGHDFLIVGRSPDVPPGSNQRYNFDPATDIYRLRGQNPTRRDVAMLPAGGWLLLAFRTDNPGAWLLHCHIAWHVSGGLSVDFLERPDDLRNSIPQHDKDEFNRVCNEWRTYWPNNPYPKIDSGLKHRWVEESEWLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3Z4</accession>
    <name>G0S3Z4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glycosyltransferase 2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0021970</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 12 (cellulase H) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692666.1">
        <property type="nucleotide sequence ID" value="XM_006692603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3Z4"/>
    <dbReference type="GeneID" id="18256235"/>
    <dbReference type="KEGG" id="cthr:CTHT_0021970"/>
    <dbReference type="eggNOG" id="ENOG502S2M7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016349_0_0_1"/>
    <dbReference type="OMA" id="FFRPEWF"/>
    <dbReference type="OrthoDB" id="72851at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06421">
        <property type="entry name" value="CESA_CelA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002594">
        <property type="entry name" value="GH12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050321">
        <property type="entry name" value="Glycosyltr_2/OpgH_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43867">
        <property type="entry name" value="CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43867:SF2">
        <property type="entry name" value="CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01670">
        <property type="entry name" value="Glyco_hydro_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408877" description="Glycosyltransferase 2-like domain-containing protein" evidence="10">
        <location>
            <begin position="25"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="451"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="744"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="783"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="854"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="881"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="11">
        <location>
            <begin position="502"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS20370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="908" mass="102455" checksum="67DA094ACD9FD589" modified="2011-10-19" version="1">MWLSRTMQLVISVAILGKPGASSSYDARLCGEGSYTTPNTNLTYVPNAWNPDAPGFQCIMIKDKPPSFDATWNWSAEAGTVHSYPHVKLTDSTFPVPLTNISALVLTAQWSMGLGSTPKPIPSLDSIALSQEDVFANVAFDLFVDHNPPESQGETSAETEVMIWLGMFGYAYPLGYKRPAKCRVTMTIGHVEFTLYYGKNQRGTHVFTWLTEVPETSFAGDVSPLLQFLWMNDLVSRRAYLGLVGFGTETWHSKGNVTFSARKYGLDVLVGPPPVLDLPPAPDCLTSSGVIAAAYITSRKLFAIVAGTVCFDLQLPPVFPAPFRPLPHVPGRTPRQATSATAQDQLHGELNEKSAFSSDDGVFQSGIRQDHPSSIEQASTKASILKRAYKAFRRTYCPGGEPPLVLPSAPTDEEKLKYIETNRIPLYIFGVFSFLSLSAGMWLFAICDPIFSWYGIFVTFLNIYLMISYFVGLIGRDWDYESHLRIREQHPITDETAPTVDIYLPCCSEPLEILENTWSHIIRLDWPAHKLKVYVLDDGDQPAVRDLAARFGFNYIVRDDRPRLRKAGNLRWAFARTESDFFAIFDADFCPRPDFLRELMVEHLADEKTAIVQSPQYFRVTDDQTWIEQGAGATQELFYRVVQVNRNRWGASICVGSNAVYRRASLVEVGGTAEIGFSEDVHTGFGAVDRGWKVKYVPLCLATGICPNTPRSFFSQQMRWARGSTTLLTTKHFWVSNLTTMQKMCYLCGLLYYSAVALGIFISPMPGPLLLFFRPEWFKYYNLAFAIPSIFYGLILFRFWAKASYGLNVQHIMVIQSYAYLTAIKDRLFGIELLWAASGDKKAHKSNKYRNMRILCWLWTLTWVGAVVASVTYRLLTGFPWYHTVPLLVLSAYNLYISHYFMFASWKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G0S440</accession>
    <name>G0S440_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0030600</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; ergothioneine biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693510.1">
        <property type="nucleotide sequence ID" value="XM_006693447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S440"/>
    <dbReference type="SMR" id="G0S440"/>
    <dbReference type="STRING" id="759272.G0S440"/>
    <dbReference type="GeneID" id="18257098"/>
    <dbReference type="KEGG" id="cthr:CTHT_0030600"/>
    <dbReference type="eggNOG" id="ENOG502QS9T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006921_0_1_1"/>
    <dbReference type="OMA" id="FKHWHPT"/>
    <dbReference type="OrthoDB" id="659at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="entry name" value="paralog of FGE (formylglycine-generating enzyme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051128">
        <property type="entry name" value="EgtD_Methyltrsf_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019257">
        <property type="entry name" value="MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017805">
        <property type="entry name" value="SAM_MeTrfase_EasF-type_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03439">
        <property type="entry name" value="methyl_EasF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397:SF1">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10017">
        <property type="entry name" value="Methyltransf_33"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine-specific methyltransferase SAM-dependent" evidence="9">
        <location>
            <begin position="66"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine-specific methyltransferase SAM-dependent" evidence="9">
        <location>
            <begin position="268"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="DinB-like" evidence="10">
        <location>
            <begin position="402"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase-modifying factor enzyme-like" evidence="8">
        <location>
            <begin position="599"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="757"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS21214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="893" mass="100738" checksum="6147D0B8C4C2128F" modified="2011-10-19" version="1">MPGLENPVLASQTGQGRLLAIKEKKRLPDVRVKIGEKASFDIIDIRQGSVEMNLKVEILSMFLTKNGPRKLPTLLLYDERGLQLFEKITYLEEYYLTNDEIEVLQKYSADIAKLIPEGAMLIELGSGNLRKVNLLLRAFEDAGKSIDYYALDLSKQELERTLAQLPHYQYVRAHGLLGTYDDGRAWLKHPSRASRQKCILSLGSSVGNFDRADAAAFLKTFADILGPGDTMLIGLDACNDPARVYHAYNDKEGVTHELASQAGSGDSADESIHRFILNGLRHANKILGETVFVEAEWRVIGEYVYDGQGGRHQAFYAPLHDTTVLGQLIRPHDRIQVEQSLKYSPAEAELLWKRAGMEEIGHWRCRDEYGVHMLSKPKMAFGLIPSVYARSALPSLEEWESLWAAWDTLTQEMLPPEELLSKPIKLRNACIFYLGHIPNFLDVQLSKVTTDPLTDPAWYRRIFERGIDPDVDNPEICHDHSEIPDEWPPADEILEYQTRVRARLRKYYENGVENIPRHIGRAIWVGFEHEIMHLETLLYMMLQSDKTRPPPNVPVPDWEKLAAKARSERVPNEWFDIPEQEITIGLDDPEDETDPNVHYGWDNEKPVRRAKVHAFQAKGRPITNEEYATYLYNTHGSQIPASWAYTKEKDPQNGVSGTNGHSTIANGTAPLPESFLEDKAVKTVFGLVPLKYALDWPVFASYNELAACAAWMGGRIPTFEEVRSIYAHVEARKKQKEAQKHLAQTVPAVNAHLCNNGVEISPPATPPAGTAAATAEGDESENSLFIDLDGANVGFQHWHPVPVTNRGGELAGQAECGGVWEWTSSVLRPWDGFKPMTLYPGYTADFFDEKHNIVLGGSWATHPRIAGRKSFVNWYQRNYPYAWVGARLVRDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>G0S451</accession>
    <name>G0S451_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">P-type Na(+) transporter</fullName>
            <ecNumber evidence="19">7.2.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">CTHT_0030720</name>
    </gene>
    <organism evidence="26">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>K(+)(in) + ATP + H2O = K(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75815"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>Na(+)(in) + ATP + H2O = Na(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:14634"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.3" evidence="19"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693521.1">
        <property type="nucleotide sequence ID" value="XM_006693458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S451"/>
    <dbReference type="SMR" id="G0S451"/>
    <dbReference type="STRING" id="759272.G0S451"/>
    <dbReference type="GeneID" id="18257110"/>
    <dbReference type="KEGG" id="cthr:CTHT_0030720"/>
    <dbReference type="eggNOG" id="KOG0202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_3_0_1"/>
    <dbReference type="OMA" id="ISWEWAL"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008554">
        <property type="term" value="F:P-type sodium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000015">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000020">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000047">
        <property type="entry name" value="Sodium P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006414">
        <property type="entry name" value="P-type_ATPase_IID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01523">
        <property type="entry name" value="ATPase-IID_K-Na"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="17" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="323"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="838"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="865"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="911"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="969"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1019"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1051"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="24">
        <location>
            <begin position="8"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="404"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1112"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="423"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="1121"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="1138"/>
            <end position="1150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00035017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00035029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="EGS21225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1158" mass="128021" checksum="204CAE2540AE0FC5" modified="2011-10-19" version="1">MAAEFPKHPFLLSIQEVEQTLGTNVERGLTSAQVAALQQKYPKNELDVGGGIAWYTIFIRQLCNAMILVLFFAMALSFGVQDYVEGSVLAAVIVLNVSIGFYQEYGAEKKMDALRALSSPSANVLRDGKIEVIPNFQVVPGDIVIMKMGDTVPADVRLFEAMNFNCDESSLTGEAIPVEKRVENNITVPGTDRVATSEEEVGIADRVNMAYATTVVRKGRGRGIVVATGMATEVGKIAASTSKKKRKPGRSMNWKKYGKTQPIKGAARRAYDFFGKFLGLTEGTPLQIKMAKLAYFLFFCALLLAVVVFGVNKFVSPLPTEVIIYAISTGIAIIPESLVAVLTISMVVATTVMRKANVVVRDLSALEALGGVTNICSDKTGTLTQGAMIVKKVWLPPSTVYSVKDSTDPSNPHAGKVTVSQTADDKGDEEKRDYDQERTTQAIKFDVPDEKLNPKLQEPKESQAELTPELRLFLLSAALCNLATVRLDETEDRWKTTGEPTEIALQVFTHRFDRGKKTLEKEGWKQVAEFPFDSSIKRMSVIYDVPADHRLGDLLNEHDSVVFTKGAVERILDLCDYIGIGENQTPVTPDTKEKVLQQMTHFASLGQRVLAVAYRPWKGRYVPGKNDGVVVTEKVTSATTDESENGSSDSNDEAARAAVETKLTLLGLAGIYDPPRRETSPSIFDCAQAGIKVHMLTGDHPETAKAIAKEVGIIPSNYGVLPAGVADTIVMKATDFDKMTDEEIDALEELPLVIARCAPETKTRMVEALRRRNAFMAMTGDGVNDAPSLSRADVGIAMGSGSDVAKSAAKIVLTDDKFNSIVAAIREGRRMFENIQKFVLHLLCSNVGEVILLICGLAFQDKTGFSVFPISPLEILWINMVTSSFPAFGLSREKASAEVMRKPPHDKKRGVFTNQILVDMLVYGTLMGICTLATFVIVVFGKDYDGLEGRARLGQDCNRHYSDSCYPVFRARAAVFAELTWLILVSAWEFKNIRRSMFHLNPDNNSRWRIFTDLYENRFLFWAVVIGGVSVFPTVYIPYLNRDVFKHTSISWEWGVVVGMTILFVLGIETWKYIKRRFHLLEDHKVPRGAWSQGEEGMRRLHRTMSFRSWRSWGRTESKSKAQSSGGLTPVPTQSKAQTQQQGESSQSQTNDRELPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4A2</accession>
    <name>G0S4A2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Sulfite reductase [NADPH] subunit beta</fullName>
            <ecNumber evidence="6">1.8.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CTHT_0039450</name>
    </gene>
    <organism evidence="24">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the reduction of sulfite to sulfide, one of several activities required for the biosynthesis of L-cysteine from sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>hydrogen sulfide + 3 NADP(+) + 3 H2O = sulfite + 3 NADPH + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>siroheme</name>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Alpha(2)-beta(2). The alpha component is a flavoprotein, the beta component is a hemoprotein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.2" evidence="6"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS22060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694356.1">
        <property type="nucleotide sequence ID" value="XM_006694293.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S4A2"/>
    <dbReference type="GeneID" id="18257983"/>
    <dbReference type="KEGG" id="cthr:CTHT_0039450"/>
    <dbReference type="eggNOG" id="KOG0560">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001975_0_1_1"/>
    <dbReference type="OMA" id="YGSYTQV"/>
    <dbReference type="OrthoDB" id="1688044at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009337">
        <property type="term" value="C:sulfite reductase complex (NADPH)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050311">
        <property type="term" value="F:sulfite reductase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004783">
        <property type="term" value="F:sulfite reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000007">
        <property type="entry name" value="Pyruvate:ferredoxin (Flavodoxin) oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000003">
        <property type="entry name" value="Sulfite reductase [NADPH] hemoprotein beta-component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000004">
        <property type="entry name" value="Sulfite reductase [NADPH] hemoprotein beta-component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000051">
        <property type="entry name" value="Sulfite reductase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.480.20:FF:000012">
        <property type="entry name" value="Sulfite reductase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000016">
        <property type="entry name" value="Sulfite reductase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.480.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="entry name" value="Sulfite Reductase Hemoprotein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01540">
        <property type="entry name" value="CysI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011786">
        <property type="entry name" value="CysI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045169">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02041">
        <property type="entry name" value="CysI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010029">
        <property type="entry name" value="PRK13504.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493:SF47">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="Nitrite and sulphite reductase 4Fe-4S domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="Nitrite/Sulfite reductase N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0349">Heme</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="22">
        <location>
            <begin position="794"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="246"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00052219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00057613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00063391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00067595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EGS22060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1532" mass="168899" checksum="D97D3C3EFD2D0538" modified="2011-10-19" version="1">MAVPQAKLRTPEEAVASIAYLASDVVVSVQPAIGTDSAFSKQLKQLAQSKTQSLVAKTSDAVPEIVPVRHNTDPLLSVFTPIRSGRLVSVTTTSSILLPSVAHLYRLANFPVVIHVALAPKRFPDYSAITAVRNSGWTFLQSWSLQEAHDIAITAHALAIRSGKGVIHFFDPSSSEGNAPIELASLDVIRTVLNLDNVRRFQSAPVPGTGIYADDGRKALVAEQAEPVIAPASAASAVAAASEVPATGASSPSATSSSAKSSQQSTNTATPTASAATTIEESAPAVTSEHIHKYATGIWSQLSSLIGRNYNAFEYKGPASAESVLLLFGSNVSLFADAILHAPSSEAFAGAGLLIPRLYRPWLGAKLLEAIPQSVRKIAVLEQISRKTTRWGPVLVDVLTSVKSTPGGVETVVGHQLGYISKTTVEQALRGVFQNLSSDKPVQNLEVGEREAPKEAPEYGLEQPALENAYIKILNKLFGNRVFIANALGSDNAGVSDTIAASPEFGFGSLLARKERRQKFVEQAKKFAIIGQFLTDVPKRALAKWATSLDDVKKTEQAAEEVISSLTIDNSTLAKTLLEGKAFFHKESLWLVGSDAWAYDLGNSGVHHVLASGENVNLLIIDSTPYSERAAADANRRKKDIGLYAMNFGNAYVASTAVYSSYTQVLQALDEADKFNGPSVVLAYLPYNDEHDSPLTVLQETKKAVDLGYWPLYRWNPDNEAKGEPKFALDSERIKKELKEFLDRENRLTQLMRSQPQYGAVLSEDYGTEIRAQQRRRAKDAYNKLLEGLFGAPLTILFASDNGNAQNVAKRLGNRGRTRGLKTIVMSMEDYPVEDLPSEENIVFVTSTAGQGEFPQNGKPFWDAIKDNTDLDLASVKYSVFGLGDSHYWPRKEDKVYYNKPAKDLDRLLSNLGATRLAPLGLGDDQDPDGYQTGYQEWEPKLWEALGVASVEGLPEEPPPRTNEDIKLESNYLRGTIAEELKDESTGAISADNSQLTKFHGTYMQDDRDIRDARKAQGLEPAYSFMIRCRLPGGVATPQQWIQMDDIANTYGNKTMKLTTRQTFQFHGVIKRNLKKAMQAINRALMTTLAACGDVNRNVMCSPLPSQSKYHREVWACSKKISDHLLPQTSAYHEIWLTDDNDKKELVAGNAVQDFEPLYGPTYLPRKFKISIAVPPHNDVDVYAHDIGLIAIKGADGHLEGFNLLAGGGMGTTHNNKKTYPQLGRMLGFVKTADVHIACEKVMLVQRDFGDRKNRKHARLKYTIDDMGVEMFKAKVEEYWGQKFEEARPFHFDSNVDTFGWQKDETGMNHFTFFIENGRIEDTPDFPMKTGLREIAKVHKGEFRLTPNQHLILSNVADEDVPLMKELMAKYKLDNLNFTGLRLSSSACVAFPTCGLAMAESERYLPVLITKLEQVIEEVGLRRDSIVMRMTGCPNGCARPWLAEVAFVGKAYGAYNMYLGGGYHGQRLNKLYRSSIKEEEILPIMKGLLKRYAAEREEGEHFGDWCIRAGVIKATKEGRDFHDGVAEEEGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4B2</accession>
    <name>G0S4B2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="2">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0039550</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="2"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS22070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694366.1">
        <property type="nucleotide sequence ID" value="XM_006694303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4B2"/>
    <dbReference type="STRING" id="759272.G0S4B2"/>
    <dbReference type="GeneID" id="18257993"/>
    <dbReference type="KEGG" id="cthr:CTHT_0039550"/>
    <dbReference type="eggNOG" id="ENOG502QPT5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031468_10_3_1"/>
    <dbReference type="OMA" id="RKEPFQV"/>
    <dbReference type="OrthoDB" id="73846at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050838">
        <property type="entry name" value="Ketopantoate_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765:SF2">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="6">
        <location>
            <begin position="7"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="7">
        <location>
            <begin position="228"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS22070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="380" mass="42048" checksum="C70CEF35EE6D1478" modified="2011-10-19" version="1">MPSKPHVHILGLGNIARYLAFELLSTISKPGISPRNLHPPRLTLLTHRPEDVAAFEKRALRSIWCHVLHDEAEGEFQVMGRTHPKGEISVQFVGDESAKGEMITYLVVATKAHQTIEALRAVRDRIGRSARVLFLQNGMGIPSLVSAILFPDPSTRPTYLAGVCTAGIKPTVPPYPFSFHLAGQGDLIFGIVPDPDDPLPRSRTPSFLEEHLPRLPHLNASLVSPQELLKAQLRKLIVNATINPLTALLRCRNGEVFGTPARKMVLEALVAEAGPVIRSLLEGSGIRKAEIENEFSDEELRNAAVKVAEATAANESSMLQDVKQKRETEVRWINGWVVEEGKKRGMECRWHEEVVSLVENRGQGERRLLGEVLEGRGNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G0S577</accession>
    <name>G0S577_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dicer-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">CTHT_0032530</name>
    </gene>
    <organism evidence="26">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="17 18">Belongs to the helicase family. Dicer subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693692.1">
        <property type="nucleotide sequence ID" value="XM_006693629.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S577"/>
    <dbReference type="GeneID" id="18257291"/>
    <dbReference type="KEGG" id="cthr:CTHT_0032530"/>
    <dbReference type="eggNOG" id="KOG0701">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000907_4_3_1"/>
    <dbReference type="OMA" id="TRKNHAY"/>
    <dbReference type="OrthoDB" id="416741at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050688">
        <property type="term" value="P:regulation of defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18034">
        <property type="entry name" value="DEXHc_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000015">
        <property type="entry name" value="Dicer-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.380:FF:000004">
        <property type="entry name" value="Dicer-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001669">
        <property type="entry name" value="Dicer-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.380">
        <property type="entry name" value="Dicer dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038248">
        <property type="entry name" value="Dicer_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005034">
        <property type="entry name" value="Dicer_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056755">
        <property type="entry name" value="DSRM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF62">
        <property type="entry name" value="DICER-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03368">
        <property type="entry name" value="Dicer_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24995">
        <property type="entry name" value="DSRM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51327">
        <property type="entry name" value="DICER_DSRBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="4" id="KW-0930">Antiviral protein</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="13 18" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="22">
        <location>
            <begin position="140"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="23">
        <location>
            <begin position="460"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="Dicer dsRNA-binding fold" evidence="24">
        <location>
            <begin position="664"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="PAZ" evidence="21">
        <location>
            <begin position="908"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="20">
        <location>
            <begin position="1076"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="20">
        <location>
            <begin position="1282"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00035116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="EGS21396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1596" mass="180333" checksum="08E06FCB3DE9820C" modified="2011-10-19" version="1">MVHDAPITGMSSPQQSPSHKKSSDAGDTEVDGYAKGLNGTDTSTDPNSPPDFDPYADADLDVPEWAKNLKPASPAKKKKVSNRHRADNAAFDIWIEQNQHALTRSERRPVSDNDKSFQALVKGLGHQEIITSPRDYQLELFERAKEQNTIAVLDTGSGKTLIAALLLRWTLQNELENRAKGMSRRVAFFLVDKVALVLQQHAVLACNLDYPIDKFCGEMIEDVEEDKSFWDKTFAENMAIVCTADILYKCLAHSYIRMDEINLLVFDEAHHAKKNHTYARIIKDFYVDVEEDKRPRILGMTASPVDAQVDPKVAAAELEGLLHAQIATAADPAALQYTLTRLKAEEIVEFDRRPDNWETPLNQRLKMLVGQYEVFHKPFAFTETACAELGPWCADRYWQLFFREEDLARLEARCEMEILGVSAYRQDTREQVSRVRQAYDLVKNHEFGRPKLSTDSLSSKVIELVKVLRKQFEDPDQDPRCIVFVKQRNTASLLVDLLQQPEMHIEGLKSGMLVGSGRADAHWDNTKVSFRNQVRTIIKFRKGVLNCIFATSVAEEGLDIPDCNVIIRYDLNETLIQYIQSRGRARRHGSIYIHMVERGNPRHRRRLHENKANEDALRRFCEALPEDRKLTGNNFNMDYFLRKEMGQQQYIVPGTGAKLNYKQALVILANFVSSLPHPPETVLAPEYVICAVPGGFQCEVMLPPQSPVRSATGKVHPRKAMAKCSAAFELCLKLIKGKYLDAHLRPVFTKQLPAMRNARLAVSAKKKAEYQMRIKPEMWARRGEPKELYVTVLALENPGAVGRETMPLLLLTREPLPKLAKFTLFYGQGPDRTSQVRCVPVPGRIVLDEEGREAKALAGFTLRVFHDVFSKDFEARVGDLPYFIAPATKGHGEGFEIEEDVRGLVDWEVVFRVQEGDRIPYDVDAAGEYADEFFKGHFVVDPYDGSRKYFLRGRRHDMKATDTVPEGIVPPGHAWRGVSTRDILNYSLTKWKRSREKTTLNPQQPVVEAELMPLRRNLLDDNIGEDDLEPKQCFLVLEPLRISPLPAKTAMMAYSFPAIIHRIESNLIALDACRLVGLDIRPDLALEALTKDSDNTGEHDAEQISFQPGMGNNYERLEFLGDCFLKMATTIAIFTLIPDKEEFEYHVERMLLICNRNLFNNALEFKLEEYIRSMAFNRHSWYPNNLTLKSGKTIQPRRTHLLADKSIADVCEALIGAALLTGQDRAGSTAPEQGAFDLAIRAVSTLVKSPRHSMSSYSEYYSLYTPPAWQTAPCSSAQVDMAARFACRLGYTFRHPRLLRSAFQHPTYPSVYEHLPSYQRLEFLGDALLDMAIVEWLFARFPGADPQWLTEHKMAMVSNQFLGCLGFMLGFHKNIACCSPQVGKDLARYVAEMEEALLAAKEDAVRAGKTEDDWARDFWLNCSRPPKCLPDVVEAYVGAVFVDSGYNFGEVRAFLERHIRPFFEDMRLYDTFANNHPVTMLVAVMQGQFRCQEWRVLARELPAGPVAVALDGEDTTSGGEFGEGETRVVCAVRCHGQTLAHAVAASGRYGKVAAAKKALEVLRKMEVEEYRQEFGCTCAGEEGGNEEELEAHASAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5B7</accession>
    <name>G0S5B7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Guanine nucleotide-exchange factor SEC12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0024240</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Guanine nucleotide-exchange factor (GEF) required for the formation or budding of transport vesicles from the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Golgi apparatus membrane</location>
            <topology evidence="10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the WD repeat SEC12 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692886.1">
        <property type="nucleotide sequence ID" value="XM_006692823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5B7"/>
    <dbReference type="STRING" id="759272.G0S5B7"/>
    <dbReference type="GeneID" id="18256462"/>
    <dbReference type="KEGG" id="cthr:CTHT_0024240"/>
    <dbReference type="eggNOG" id="ENOG502SFDW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021000_0_0_1"/>
    <dbReference type="OMA" id="EPQLAIF"/>
    <dbReference type="OrthoDB" id="16538at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003400">
        <property type="term" value="P:regulation of COPII vesicle coating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045260">
        <property type="entry name" value="Sec12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284:SF0">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 10" id="KW-0813">Transport</keyword>
    <keyword evidence="2 10" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS20590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="629" mass="68312" checksum="1BEE184EC5B287FA" modified="2011-10-19" version="1">MTVPTATLRLSYPLYALDFDPTSRDAKRLVVAGGGGSSTKSGIGNKLTVLALDDEAKEIQISAEIDLSREEDAVSSLAVESRPVKGKDGKGEIVRIYAGVNSSLESIKKGKNEHLRVFDATLSHKTASSSDEKDSEKKQFQGKITESSRTTLFSARDPDAYQRLLRISPPLAAAATGTTGPSSRDSQIALFDLPSPTQINPNLRGTLELAKEATDMDMLRVSDSQHRLVYVDERDMYLVAISEDGHVSSPRCVFSMPIDTAAGQTVRPTFRCVRFLTETFVLAVANLPRGGGAILQGFRLPTNLSAAAGENEGEAKARLAISAKLPKHVARATNLAVRGLTPSKGKVGDAQFVVAVSGQDSSVLVYTLEHTTLVQADVCLVSQLRRVVDWREVHQGPISGLAFSYIAPPSEKEEEETPVLRLASIGSMGNTVVVHTLPLRPHPSSKPKQKRYILGLRSSPVIAPTQMIVVTAIVFALLALFLQGAMEVKGLTRPVLGARQVVPESWLGREVWREIEQHQKGKRYYKGDSLWDRYQAAVEYQRDHGQNAVVLKAGGKESDEEGVDIDVVTSGTAEGESTGKQWDELAPAQREAWKERLKRAGQWSEEMGEAVLKGVLFGEIAGVVRGLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5H9</accession>
    <name>G0S5H9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0033020</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693740.1">
        <property type="nucleotide sequence ID" value="XM_006693677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5H9"/>
    <dbReference type="STRING" id="759272.G0S5H9"/>
    <dbReference type="GeneID" id="18257340"/>
    <dbReference type="KEGG" id="cthr:CTHT_0033020"/>
    <dbReference type="eggNOG" id="ENOG502QW5G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012945_0_1_1"/>
    <dbReference type="OMA" id="HWWLPND"/>
    <dbReference type="OrthoDB" id="5278208at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="25"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS21444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="622" mass="70043" checksum="D1C46D720C833FCE" modified="2011-10-19" version="1">MSEYYQYLSSMSMVGVGGQLAHNHPDVTGQCDETHPICENPSQPKGSSGNNNSKESSAGPSQQPSPESSKGEDEEEAELDTKLETIMDEDEEEPESATSQTPTPGLPTRRSSTTSSLGPQRAGGDNRHGSETPSFEGLNRSSPALTMGTANPQTPIGLNFPSSSSARPDWTFLTHEMQFYLNYFYDNVTHYHYCATSDLDDFFRTILTTEATRNEALLYAVVAFSAYHHAMKDPNGRINEFLQFYSRSVRLLLECLKKKENYNIGTLLTILQLATIEEYLGDWINLMGHKKAAFEVLTQLYDPHSAMQSPVGRMAVTWYARFDVITSVMGCLAPSMSREWFTAQVEHYQDRATAEPQNVGCKFELWSARLRLIMMEMGLLYAKRAKRDISEDEYAAEHQRLAVVLEEWKNSWDPAMTDPSFLLTDLPTNNSDINPFTPEPLFQPPLFVATALVCEYHSLALMHASQSSIKLTDEAKAGLRERANAICRIVEAVEVWQGSPLGSLILLQACMVMASFYVRRDARHHMWLRRRYASLESMGYISPMTLRTRMAELFNDQSCVRWWLPNDEGFTPLLQSIRALADERNLMAASAQSETLQQIRHVFSRMQIGPDDGDTDMKDATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5J8</accession>
    <name>G0S5J8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Origin recognition complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0033210</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693759.1">
        <property type="nucleotide sequence ID" value="XM_006693696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5J8"/>
    <dbReference type="STRING" id="759272.G0S5J8"/>
    <dbReference type="GeneID" id="18257359"/>
    <dbReference type="KEGG" id="cthr:CTHT_0033210"/>
    <dbReference type="eggNOG" id="KOG0955">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2228">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007115_1_0_1"/>
    <dbReference type="OrthoDB" id="343623at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15492">
        <property type="entry name" value="PHD_BRPF_JADE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001597">
        <property type="entry name" value="Origin recognition complex subunit Orc4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016527">
        <property type="entry name" value="ORC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032705">
        <property type="entry name" value="ORC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12087">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12087:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14629">
        <property type="entry name" value="ORC4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="610"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="319"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="559"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="420"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="500"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="512"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="577"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS21463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1142" mass="125406" checksum="19102A22FC6314F8" modified="2011-10-19" version="1">MGNIDDPTNNINKQILNRPIRHNQYIEDPLKHFLSIPWAARLLQDPDLVEIIVPDRSHLPSGDLQFTRKVMNGPGCVRACVAFRRPVPPEQLVVKVLSVNESLLNSNELNQVKGLGILNAERERYIGSPRPCPSDFGLLEEAGPDYGESKEKPFLLLNALLDVGKDMTSYENCLHGGAIMAFLDESMVSAAHNLSSEFSPSCQLALTRTDEKADRRGDAEHAVTAEMTTTLLKPVRLPCIVLVRARVISRMGRKMVARAALENEKGEILARSQGVLIDMTTHNTVGGEMEKTHFIPATSATKKQRIKLSDNKATATNYSLHDANPVTKKASATRRGAPSLAAKATNTQSAKTDTWEVPDSEEERHKPAINKPDKPNPKRSQDAVSSKQKSNVYDVPDSDEDELANPAVTRQSRLRRSHHASSVPAAVDAAPQPAKEEDEPEPPKKRRGRPPKKFKESQTSTVNDETAIVTREPSPTAPRPSTRATGRVRPSCNGAVNSDKTAAGVTVVAKASSKEPANDHTDGHESRPLKGILTPRKQRGDANHLRAVKSVAFDDKPDEDALDSLATQTPSKSNRKPQQDATRKLKVTDTEPKAKPQDSSQESGEEEEDDEVCAICLKPDSAPPNEIVFCDSCDMPVHQECYGIPEIPEGEWICRNCSQEGINSRGEGVAYESNTAIGALEEQRPDIPNFDQHLQLAQRVLLDRCAGRRRIKLRGQDDAYKKAHQLVEQTVVAGEGNSMLVIGARGSGKTTLVESIIHDMAKNHGDDFHVVRLNGFIHTDDKLALREIWRQLGKEMEVEDELVNKTTNYADTMASLLALLSHPSEIAETQEGVTSKSVIFVIDEFDLFATHPRQTLLYNLFDIAQARKAPIAVLGLTTRIDVVESLEKRVKSRFSHRYVYLSLPTSLPAYWDICKQGLTVDNEDMLSEGIDPALEGHHAFWDWWNGRIESLYKTQSFADHLESYFYRSKSVAAFFTSCILPLASLSPTAPFLTIPATSGLAAIVSLEPPDSKLHLLSSLSDLDLSMLIAAARLDIVAHTDTVNFAMAYDEYTSLMSRQRVQSAASGMLALGGGARIWGRGVASMAWERLATLGLLVPAAPGGRGMAGLGGLDAKMWKVDVALEEIPAAVKLNAVLARWCKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5S2</accession>
    <name>G0S5S2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">isopentenyl-diphosphate Delta-isomerase</fullName>
            <ecNumber evidence="4">5.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0033420</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:23285"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IPP isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="4"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693780.1">
        <property type="nucleotide sequence ID" value="XM_006693717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5S2"/>
    <dbReference type="STRING" id="759272.G0S5S2"/>
    <dbReference type="GeneID" id="18257380"/>
    <dbReference type="KEGG" id="cthr:CTHT_0033420"/>
    <dbReference type="eggNOG" id="KOG0142">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060552_0_2_1"/>
    <dbReference type="OMA" id="KAPFDNG"/>
    <dbReference type="OrthoDB" id="510307at2759"/>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009240">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02885">
        <property type="entry name" value="NUDIX_IPP_Isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000012">
        <property type="entry name" value="Isopentenyl-diphosphate Delta-isomerase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011876">
        <property type="entry name" value="IsopentenylPP_isomerase_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02150">
        <property type="entry name" value="IPP_isom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885:SF0">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018427">
        <property type="entry name" value="Isopntndiph_ism"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="13">
        <location>
            <begin position="74"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS21484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="253" mass="29273" checksum="50AF9E0845E6BAA9" modified="2011-10-19" version="1">MAASTVTTETRITADNILRLFPDIDTSSEALEGHDEEQIRLMDEVCIVLDENDVPIGTASKKLCHLMTNIDKGLLHRAFSVFLFNEKNELLLQQRASEKITFPNMWTNTCCSHPLNVSNETGSTLEAAILGVKHAAQRKLEHELGIKKEQVPLEKFRFLTRIHYKAPSDGKWGEHEIDYILFIKANVDLNINKNEVQATRYVTPEELKQLFQDPTLKFTPWFKLICQSMLFEWWAHLESGLEKFENEQQIRRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5U4</accession>
    <name>G0S5U4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial</fullName>
            <ecNumber evidence="6">1.1.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Isocitric dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">NAD(+)-specific ICDH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CTHT_0033640</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:23632"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Octamer of two non-identical subunits IDH1 and IDH2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.41" evidence="6"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693802.1">
        <property type="nucleotide sequence ID" value="XM_006693739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5U4"/>
    <dbReference type="STRING" id="759272.G0S5U4"/>
    <dbReference type="GeneID" id="18257402"/>
    <dbReference type="KEGG" id="cthr:CTHT_0033640"/>
    <dbReference type="eggNOG" id="KOG0785">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031953_0_1_1"/>
    <dbReference type="OMA" id="VRPCRYY"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000003">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF34">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="53"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGS21506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="382" mass="41362" checksum="E8818F8A390F616C" modified="2011-10-19" version="1">MFALRSIAAPMQRQCFRAAPRAAVSLSLQSRFYSSQDSIAKFTGQKDAQGRYTVSLIEGDGIGPEISAAVKDIFAAAKTPIVWEPINVDPVLKDGKTTIPDAAIESIKKNKVALKGPLATPIGKGHVSLNLTLRRTFNLFANLRPCRSVAGCKTPYDNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQHARAIGRKKVRVVHKATIMKMSDGLFLDVGRRVAQEFPDIEFDAELLDNTCLKMVTDPVPYNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDECSIFEAVHGSAPDIAGKNLANPTALLLSSMMMLRHMGLNEYADRIEKAAFDTLAEGKHLTGDLGGKATTTEYAQAIIAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0S639</accession>
    <name>G0S639_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BRO domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0034070</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693843.1">
        <property type="nucleotide sequence ID" value="XM_006693780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S639"/>
    <dbReference type="STRING" id="759272.G0S639"/>
    <dbReference type="GeneID" id="18257445"/>
    <dbReference type="KEGG" id="cthr:CTHT_0034070"/>
    <dbReference type="eggNOG" id="KOG2220">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003661_0_0_1"/>
    <dbReference type="OMA" id="CHAANQS"/>
    <dbReference type="OrthoDB" id="2141925at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09242">
        <property type="entry name" value="BRO1_ScBro1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09237">
        <property type="entry name" value="V_ScBro1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF30">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="8">
        <location>
            <begin position="7"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="562"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="774"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="707"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="775"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="792"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="824"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="863"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="883"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="905"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="935"/>
            <end position="953"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS21547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="963" mass="107784" checksum="FFB42021A9EA6B8C" modified="2011-10-19" version="1">MTGTQSPMISVPLKATNEIDWITPLKTYIRDTYGDDPERYSEECATLNRLRQDMRGAGKDSTAGRDLLYRYYAQLEFLDLRFPIDEQHIRVSFTWYDAFTHKGTSQYSLAFEKASIIFNISAVLSCHAANQTRSHESGLKQAYHSFQAAAGMFTYINENFLHAPSADLSRDTLKTLINIMLAQAQEVFLEKLITDQKKIGLLAKLASQAATLYGQALEGVQENVTKAVFEKVWLLMVQIKFKFMSSLAQYYQALADNDANSHGMAIARLQVAESHIREANKIATNFPSSVPPNSNLTAECGPILADITRRHLVAVQQKLKELTRENDLIYHDPVPSEASVPPVAKLPAAKPIPVSELYAGQDIQRITGPDLFAKIVPLAVTESASLYDEEKAKLVRAETERVETDNSEMAAALDYLRLPNALNILKGGFDQEVLPDEDFRTWCVDVADHEDPSKIFEFLHAEKQAIVAILDRSTKQLDTEESVCEKMRSKYDSEWTQQPSAPLTTTLRSDIRNYREALEEAARSDSQLAAKLRQNENEFAEMRTAAQTGEIDALFQRAVSKARKSSNSTSPATEPNLLDADFDDGRPSVLDQIAKVEDILKKLNLIKRERVQVLKDLKEKVPIANYEQQLFQQELEKYRPYQTRLVQATHKQASLLRELTITFNNLLQDKRVRAEQSRYESFQRSRAFAINKYKRAYQEFLDLEAGLQSAKTWYKEMRETVESLEKNVESFVNNRRAEGAQLLNKIEQERAKSKSDQAALEQERLKALMERMSLEPPPTSLPTTRPVPAPLSFSSTGYPKTTYATQYPLPSSPPPTQTTVPQSYLQQPPSQTGFTYNPSSHGRIPGPASPPPTQTTFNIGPPSRGPASPPPTQTTFSQPGSGMYSTYGNPHSQPSVGGGYTIPPNFVPPPPPPGPPPLGPQQTIHYGNEHYPADPNSTLGRPGSAQQHFQGQQDPWAGLSAWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6N2</accession>
    <name>G0S6N2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial import inner membrane translocase subunit TIM54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0034980</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIM54 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693930.1">
        <property type="nucleotide sequence ID" value="XM_006693867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6N2"/>
    <dbReference type="STRING" id="759272.G0S6N2"/>
    <dbReference type="GeneID" id="18257536"/>
    <dbReference type="KEGG" id="cthr:CTHT_0034980"/>
    <dbReference type="eggNOG" id="ENOG502QSFX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039097_1_0_1"/>
    <dbReference type="OMA" id="KRNIAKW"/>
    <dbReference type="OrthoDB" id="5598305at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021056">
        <property type="entry name" value="Mt_import_IM_translocase_Tim54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF101">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11711">
        <property type="entry name" value="Tim54"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS21634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="402" mass="46355" checksum="D3F3605D46ABB479" modified="2011-10-19" version="1">MAEPTPAPPPQPTVNAVPKAPSTNPALRILGLPNLPKKLPSRNWMIFWTVSTAIAAAIIYDKREKKRNIAKWRHAVEHLANEPLPSGSFGLAQPRKLTIYLSAPPGDSLRSAQDHYTEYVKPILAASGLDWEFVQGRREGDIRAYVAERIRRVRRSLEGKEERDPTKPPSKEEIVEEFRKSRGIRDYDGIRGDIVIGRHTWKEYLRGLHEADYPSSPLPPHIPPAFHPTAPIREPHLLGFLNTPIRLYRYFNRRKLADDIGREVAAVCLCTYREFRQLQANPDSTPSDNEPWNQPAQYEQQAELAWEEKDWVKSVWKEADQVDPEVPEKVRPKPIVMDPRIAIRMRRFALTPADEERVSRIIVPEEEVEGWIKGNLRALYRWGYQKAFVKEKRTPLEDKDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6W5</accession>
    <name>G0S6W5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">E3 ubiquitin ligase complex SCF subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0027110</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Controls sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SKP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693169.1">
        <property type="nucleotide sequence ID" value="XM_006693106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6W5"/>
    <dbReference type="STRING" id="759272.G0S6W5"/>
    <dbReference type="GeneID" id="18256749"/>
    <dbReference type="KEGG" id="cthr:CTHT_0027110"/>
    <dbReference type="eggNOG" id="KOG1724">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059252_4_0_1"/>
    <dbReference type="OMA" id="DKYTASM"/>
    <dbReference type="OrthoDB" id="2342932at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18322">
        <property type="entry name" value="BTB_POZ_SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000026">
        <property type="entry name" value="E3 ubiquitin ligase complex SCF subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028729">
        <property type="entry name" value="E3_ubiquit_lig_SCF_Skp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="6">
        <location>
            <begin position="8"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component dimerisation" evidence="5">
        <location>
            <begin position="118"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00045385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR028729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS20873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="168" mass="19427" checksum="6A0A8EDA1A215A32" modified="2011-10-19" version="1">MADKSTQKVILLSNENSQIEVDRVVAERSMLIKNLIEDLGDDAVMGTPIPIPNVNDPVLRKVIEWCEHHRNDAPQTADDDNDSRKKTTDIDEWDQKFMQVDQEMLFEIILAANYLDIKPLLDVGCKTVANMIKGKSPEEIRKTFNITNDFTPEEEEQIRRENEWAEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6W7</accession>
    <name>G0S6W7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CTHT_0027130</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693171.1">
        <property type="nucleotide sequence ID" value="XM_006693108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6W7"/>
    <dbReference type="STRING" id="759272.G0S6W7"/>
    <dbReference type="GeneID" id="18256751"/>
    <dbReference type="KEGG" id="cthr:CTHT_0027130"/>
    <dbReference type="eggNOG" id="KOG2784">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025086_2_0_1"/>
    <dbReference type="OMA" id="QIEGWVM"/>
    <dbReference type="OrthoDB" id="238316at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2330:FF:000002">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000028">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040725">
        <property type="entry name" value="PheRS_DBD3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003210">
        <property type="entry name" value="PRK04172.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF40">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18553">
        <property type="entry name" value="PheRS_DBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 18" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="17">
        <location>
            <begin position="208"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGS20875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="492" mass="55648" checksum="6E62763B656FEFBF" modified="2011-10-19" version="1">MASAYNNSTGDLTSQILQALDKADPISSAEAFPQVTFEAIKAALDRLASRSMVTYEQVEREEALLEPEAEEIVAHGSHEARVFEAVRKALDGLTLQDLETTIGDKTVTKLGQGKAFKEKWIKKDGTKLVALLKKRKLLKMQKVISFRISKGPKFALQLVKEETDLTAELIVSGAWKTATFRIAHTVPEPYNFNALGADQRAGALHPLNKVRQEFRQIFFEMGFTEMPTNQFVESGFWNFDALFVPQQHPARDLQDTFYVSDPPKADRPKPVSAEDKQDYDEYFQNVRQVHQDGKYGSIGYRYPWSEDESLRLVLRTHTTAISAAMLHKLAGQRTKDGRVPPARYFSIDRVFRNETVDATHLCEFHQVEGVIADYGLTLGGLMEFMEIFFGAMGVTDLRFKPAYNPYTEPSMEIFSYHKGLNKLIEIGNSGIFRPEMLEAMGLPKDMVVYGFGLSLERPTMIKYGISNIRELLGHQVDLNFVQKNPAVRLDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6Z3</accession>
    <name>G0S6Z3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATPase synthesis protein 25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0035570</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Mitochondrial mRNA stabilization factor.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Probable mitochondrial mRNA stabilization factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Mitochondrion inner membrane</location>
            <topology evidence="2 8">Peripheral membrane protein</topology>
            <orientation evidence="2 8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the ATP25 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693987.1">
        <property type="nucleotide sequence ID" value="XM_006693924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6Z3"/>
    <dbReference type="STRING" id="759272.G0S6Z3"/>
    <dbReference type="GeneID" id="18257595"/>
    <dbReference type="KEGG" id="cthr:CTHT_0035570"/>
    <dbReference type="eggNOG" id="ENOG502RGZN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016140_1_0_1"/>
    <dbReference type="OMA" id="CLSSWVP"/>
    <dbReference type="OrthoDB" id="107372at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140053">
        <property type="term" value="P:mitochondrial gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048255">
        <property type="term" value="P:mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000044">
        <property type="entry name" value="ATPase synthesis protein 25, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040152">
        <property type="entry name" value="Atp25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28087">
        <property type="entry name" value="ATPASE SYNTHESIS PROTEIN 25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28087:SF1">
        <property type="entry name" value="ATPASE SYNTHESIS PROTEIN 25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02410">
        <property type="entry name" value="RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS21691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="673" mass="75375" checksum="33DCC19F8F70BE94" modified="2011-10-19" version="1">MVPASALRAARCSACSCAALRLVPAISANARLPALNAIARPLNTAQAPRFSTFRPTPCLLSGPALEERLDDKHKDQKATTSDGEVPWYLQVEAPRHPTLLQKPVPLPEIPEGSPRLMEPLLKYVSDELGMDDLELLDLRELDPPAALGPRLIMLFGTARSERHLHVSADRLVRWLRGKGVSASADGLLGRNQLKVRLRRAARKAKLLGSSGVGANVDDGIGTGWICVHLGAVEGSNEEIQFLDEQGRPTGFGVPDTGTTIVVQLMTEAKREELDLEGLWRDTLDKSLRKNKGLPVSEKPQEITILPPDRSSSVRSERHLDPAGSRYFSTWTRRLNINLSLDFSDNPLSSVVLGGCQESSAAQAAHMLHQDTKSKLYVLTQLRSYLKRLSKDEVDAILVKHPEVAPSPFLQLYDRAMENLAPVLAWEHRMWLWNTARSRDLPGYDLGVAKNWLREILLSSPVMTRGIALHLIQSVFAVPASTDVVARDQAALVMEVIDSMFARGQKVLDHDVLVTVIEALVRHPSPSSEAARILAQFEDLLVQADLPCPSEDLIIRLMYAYADQGRWERFWDVWRIPPRYCQGRSWRLYAHAYRIFAKDAHRARCIDALRRLYYEMKHEEPPVPINDSIRKNLKDCIDIADPAASEIARQCAERRLKIVKDREFVAMLLENDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G0S707</accession>
    <name>G0S707_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thiaminase-2/PQQC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0035710</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694001.1">
        <property type="nucleotide sequence ID" value="XM_006693938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S707"/>
    <dbReference type="GeneID" id="18257609"/>
    <dbReference type="KEGG" id="cthr:CTHT_0035710"/>
    <dbReference type="eggNOG" id="ENOG502QQ9D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055855_0_0_1"/>
    <dbReference type="OMA" id="IPNWTSE"/>
    <dbReference type="OrthoDB" id="37730at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19357">
        <property type="entry name" value="TenA_E_At3g16990-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053261">
        <property type="entry name" value="Polyketide-peptide_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41813">
        <property type="entry name" value="REGULATOR PAB1642, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11955)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41813:SF2">
        <property type="entry name" value="REGULATOR PAB1642, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11955)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS21705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="30954" checksum="19E58FCDC0E72887" modified="2011-10-19" version="1">MACWSLTSHLLSSQPELYKAATRSDFLLAGAEGRLPKEILGKWLAADRLYIHSYIRAAGQLLSSLDFPTYVDPFGKEDAAWETQLADWLIEALVAIRREESFFIDISKRYGLSLEVLGPSSNDSVQQPTALERMQKIFADVTPHVSAHACGTSMSTPLLPWLEGAVTFWGTERVYLDAWSFAHAKAAERSRGSPADGHQDADGGALRKEFIPNWTSPEFVAFVERLGSIVDQAVQKVLDAAQAEVGKAEKIKSEILARVESRWRTLLEAERDFWPIMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7L4</accession>
    <name>G0S7L4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein-sorting-associated protein 36</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ESCRT-II complex subunit VPS36</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0036750</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the endosomal sorting complex required for transport II (ESCRT-II).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the VPS36 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694101.1">
        <property type="nucleotide sequence ID" value="XM_006694038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7L4"/>
    <dbReference type="STRING" id="759272.G0S7L4"/>
    <dbReference type="GeneID" id="18257713"/>
    <dbReference type="KEGG" id="cthr:CTHT_0036750"/>
    <dbReference type="eggNOG" id="KOG2760">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015433_2_0_1"/>
    <dbReference type="OMA" id="RVCYVDH"/>
    <dbReference type="OrthoDB" id="271448at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000165">
        <property type="entry name" value="Vacuolar protein sorting protein (Vps36)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000527">
        <property type="entry name" value="Vacuolar protein sorting protein (Vps36), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021648">
        <property type="entry name" value="GLUE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037855">
        <property type="entry name" value="Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13128">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13128:SF12">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11605">
        <property type="entry name" value="Vps36_ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51495">
        <property type="entry name" value="GLUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0967">Endosome</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GLUE N-terminal" evidence="8">
        <location>
            <begin position="6"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="94"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS21805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="525" mass="57972" checksum="0B3890DCB25470F5" modified="2011-10-19" version="1">MFLKHIDLTTALRPSYLPDEDLLFVQDNVGLYEGKYKLPNHQNGQIYLTSHRICYIDKAEPRKYSVALDLKDIERYEFYGGFLKSSPKITLFPKANKRPSAHPQPTSLSRISSHHGTASLGHQSDRQPVAPALQASPVSTATWCPRYIPPEIAQQIRADTGSPGPYLTSSGIGSSNLENPESVKISFRGGGEKTFYERLKSCMAQRKWLLQSAPPIPKPSRPGDAVNGTSNGTDLEARDKPKIGGIAGLERRGQAMRKNNEIMIGSAFEDLEALMASAKEIVALAEDFARQVKGASGGLSASENALLADSVSQLGLITTKDIVGSSSGTDSLYHSELARTLAEFLTDDQRGVLKKAGGIISLVDLWAMFNRARGGVELVSPADFEKAVNLFEKLNLPLRLRTFKSGVKVVQSKDRTDEATIQAILSWLQDLREFPPEKEVPWDWHRFGRGVTARDVAERFGWSIGVAEEELEMAEERGVVCREEGIEGLKFWINFIDTGEGKGYKDPAEQEHEIIKARLKEAGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7P9</accession>
    <name>G0S7P9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="16">1.3.8.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">2-methyl branched chain acyl-CoA dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">2-methylbutyryl-coenzyme A dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="ORF">CTHT_0037110</name>
    </gene>
    <organism evidence="32">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="32">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>(2R)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = ethylacryloyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:65296"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:156439"/>
            <dbReference type="ChEBI" id="CHEBI:156440"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:65297"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>(2S)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48256"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57337"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:88166"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:48257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43780"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57336"/>
            <dbReference type="ChEBI" id="CHEBI:57337"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:43781"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>2-methylpropanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = 2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:44180"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57338"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62500"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:44181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>butanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:24004"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:24005"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>hexanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43464"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62077"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:43465"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>valproyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-propylpent-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:65344"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:156457"/>
            <dbReference type="ChEBI" id="CHEBI:156458"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:65345"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 27">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Amino-acid degradation; L-isoleucine degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; mitochondrial fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 27">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.5" evidence="16"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694136.1">
        <property type="nucleotide sequence ID" value="XM_006694073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7P9"/>
    <dbReference type="STRING" id="759272.G0S7P9"/>
    <dbReference type="GeneID" id="18257749"/>
    <dbReference type="KEGG" id="cthr:CTHT_0037110"/>
    <dbReference type="eggNOG" id="KOG0139">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_0_0_1"/>
    <dbReference type="OMA" id="DAMFSYC"/>
    <dbReference type="OrthoDB" id="10262177at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003853">
        <property type="term" value="F:short-chain 2-methyl fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046395">
        <property type="term" value="P:carboxylic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01158">
        <property type="entry name" value="SCAD_SBCAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000012">
        <property type="entry name" value="Acyl-CoA dehydrogenase short/branched chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase short/branched chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000001">
        <property type="entry name" value="Acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF1">
        <property type="entry name" value="SHORT_BRANCHED CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8 27" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7 27" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 27" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="30">
        <location>
            <begin position="60"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="29">
        <location>
            <begin position="174"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="28">
        <location>
            <begin position="281"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00039850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00049552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00051903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="EGS21840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="436" mass="47662" checksum="9B4DBD37002DB069" modified="2011-10-19" version="1">MRSFARALRPAVRRSQAVSAPRLRSGTAFSAVQTTRPLSTTAVRRDISDLIPTPITHLSEVESAMADSVRKFANEVILPKVRDMDEAEQMDPAIVEQLFEQGLMSVEIPEEYGGAGMNFTAAIVGIEELARVDPSVSVMVDVHNTLVNTAVLKWGSEALKKKYLPRLATKTVGSFCLSEPVSGSDAFALATRAVETEHGYKINGSKMWITNSMEAEFFIVFANLDPSKGYKGITAFIVDKGMKGFSIAKKEKKLGIKASSTCVLNFDDVEVPKENLLGEKGQGYKYAISLLNEGRIGIGAQMTGLALGAFENAVKYVWNDRKQFGQLVGEFQGMQHQIAQAYTEICAARALVYNAARKKEAGEEFVKDAAMAKLYSSQVAGRVASLAVEWMGGMGFVREGLAEKFFRDSKIGAIYEGTSNIQLNTIAKILQKEYTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7Q5</accession>
    <name>G0S7Q5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0028450</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693301.1">
        <property type="nucleotide sequence ID" value="XM_006693238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7Q5"/>
    <dbReference type="STRING" id="759272.G0S7Q5"/>
    <dbReference type="GeneID" id="18256883"/>
    <dbReference type="KEGG" id="cthr:CTHT_0028450"/>
    <dbReference type="eggNOG" id="KOG0600">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_17_4_1"/>
    <dbReference type="OMA" id="RPGWNGQ"/>
    <dbReference type="OrthoDB" id="204883at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008024">
        <property type="term" value="C:cyclin/CDK positive transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07840">
        <property type="entry name" value="STKc_CDK9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000440">
        <property type="entry name" value="Serine/threonine-protein kinase bur1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000270">
        <property type="entry name" value="Serine/threonine-protein kinase bur1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF546">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="372"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="684"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="166"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="192"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="273"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="684"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="736"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="760"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="772"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="788"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS21005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="804" mass="88648" checksum="E9779146A504C103" modified="2011-10-19" version="1">MSARGGFRGGFNPQLQHGYPPKGPYDGRGYGPSSGHGTPVSSFHGSPTAHSPYGGGGRGWNPQPQYSPQGSQYASPYPPPHNNFAPPAGPQGIYHQVPAHSPPYPPTGPSAQYSPTGPYRGNGRGAPGPFRGNQFSPPRGGFRSGFKSTQWQPQPTNGRGQHGQGEAPEAAHAAPEPSSAARLEQPASQGDVEMKDSDDNPFRPPKELQVEDANAKEEQQKNDKMPPPARPPPTGPQSQTSNKFSFSMKNAVKPPVASPRPEISSKFNAAPTPREPPQKPVAQKPPPPLLRMDRDRGFPKNAPTEPASARPRPGIPTGPSAMTDRRPPEPARPPPDTTPKTRKVKKIVKRLKEKPKLPPDLAASKSVFFRKPGNESVVGSGTYGKVFKAMNVYTKKLVALKRIRMEGERDGFPVTAVREIKLLSSLSHKNVVKLLEVMVENNECYMVFEYLSHDLTGLLNHPTYQLEPCHKKHLAQQLFEGLDYLHTRGVLHRDIKAANILVSNEGILKLADFGLARFYAKHHQLDYTNRVITIWYRSPELLLGETQYGPAVDIWSAACVLVEIFTKRAIFPGDGSEINQLDKIYSVLGTPTKNDWPNIVEMPWFELLRPTYRRPNVFEQKYKDLVTPAAFELLKWMFRYDPAKRPSAADVLQHAYFTEEEPAPRQAIELKDIGGEWHELESKALRREREKKEREQREKEQKERAAHAAGQSAPALSSKGEPAPQISQPVPTTGPEPRDNDRKRPNPDSSGAGGIGEGDILQREAKRLHVDQTAASSSQTQGQRLPIVAPPPPPPPPSSRQQVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7T5</accession>
    <name>G0S7T5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">DNA polymerase</fullName>
            <ecNumber evidence="22">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">CTHT_0028750</name>
    </gene>
    <organism evidence="28">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 22">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 22">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="22"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693331.1">
        <property type="nucleotide sequence ID" value="XM_006693268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7T5"/>
    <dbReference type="STRING" id="759272.G0S7T5"/>
    <dbReference type="GeneID" id="18256913"/>
    <dbReference type="KEGG" id="cthr:CTHT_0028750"/>
    <dbReference type="eggNOG" id="KOG0969">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000203_2_0_1"/>
    <dbReference type="OMA" id="CNNCRPR"/>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05777">
        <property type="entry name" value="DNA_polB_delta_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05533">
        <property type="entry name" value="POLBc_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.342.10:FF:000009">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050240">
        <property type="entry name" value="DNA_pol_type-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025687">
        <property type="entry name" value="Znf-C4pol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322">
        <property type="entry name" value="DNA POLYMERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322:SF23">
        <property type="entry name" value="DNA POLYMERASE DELTA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14260">
        <property type="entry name" value="zf-C4pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 22" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 22" id="KW-0235">DNA replication</keyword>
    <keyword evidence="18 22" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15 22" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="14" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16 22" id="KW-0408">Iron</keyword>
    <keyword evidence="17 22" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7 22" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="20 22" id="KW-0539">Nucleus</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 22" id="KW-0808">Transferase</keyword>
    <keyword evidence="13 22" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 22" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="25">
        <location>
            <begin position="243"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="24">
        <location>
            <begin position="540"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="domain" description="C4-type zinc-finger of DNA polymerase delta" evidence="26">
        <location>
            <begin position="1009"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF14260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="EGS21035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1108" mass="125625" checksum="4142251A9FBE5E38" modified="2011-10-19" version="1">MPAATLPQKRVFGEAPSTRQNIASNPPSTTKKRRLDEIPSSSPTARFSSSQTNIKGKLASSQHKSTFETEVLERMSQDINGLKESNAEKDQVWDRPPVPKDWDPEKHSLTFQAIEAEEGSLAGGQATVKLFGVTDKGNSVLLHVRDFKHYLYVQAPVSFTHDDCPLFQAYLEKQMGMTQPVIHSVTLTMRENIYGFQGNVQNPYLKITVTDPKFINKVRTMIERGEANWKGMWKSSDGTIMTYDNIQYLLRFMVDTSLAGMAWVEAPAGKYTVMTGNEKQSNCQIEAQMSYRDMIAHKPVGEWSKMAPLRILSFDIECAGRKGIFPEPQHDAVIQIANIVTTYGENKPFVRNVFCLDTTSPIVATQILSFDKEEQMLAAWQNFLVRVDPDVITGYNIANFDFPYLLDRAEHLNVPKFREWSRLKGVKSVARDTNFSSKQMGNRDTKATNISGRLQLDLLQLIQRDHHLRSYTLNSVCQHFLGEQKEDVHHSMITELFEGTPESRRRLALYCLKDAYLPQRLMDKLSCLENYTEMARVTGVPFNFLLARGQQVKFLSQLFRKALEQKLVIPNLRSESSEEQYEGATVIEPVRGYYDVPIATLDFASLYPSIIMAHNLCYTTLIKKKDVEKWNLKKDEDYIVTPNGDMFVTTKQRKGLLAQILEELLAARKQAKKELAAETDPFKKAVLNGRQLALKISANSVYGLTGATNGKLPCLEIASSTTAFGRQMIMKTKEEVEKRYCIANGYSHDAQVIYGDTDSVMVKFGTRDLKEAMKLGQDASEYVSSKFIKPIKLEFEKVYFPYLLINKKRYAGLYWTRPEKFDKVDTKGIETVRRDNCLLVQTVIDKVLRMILIDQDVPGAQEYVKSTIADLLQNKIDMSKLVITKALTKEDYAAKQAHVELAQRMKKRDPGSAPSLGDRVAYVMVKGATGSKNFERSEDPIYVLEHNVPIDTKYYLDNQLAKPLGRIFEPILGEAKARSLLTGDHTRSISVAAPTVGGLMKFAKKTQTCMACKKPLTGKEESNGAVCKDDAPRVAELYKRTLDKVSELEVRFGRLWTQCQRCQGSMHCEVICSSKDCPIFYMRMKAKKDLEDANRELARFDYDQAAIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>G0S842</accession>
    <name>G0S842_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Non-specific serine/threonine protein kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0029300</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. TRA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693385.1">
        <property type="nucleotide sequence ID" value="XM_006693322.1"/>
    </dbReference>
    <dbReference type="SMR" id="G0S842"/>
    <dbReference type="STRING" id="759272.G0S842"/>
    <dbReference type="GeneID" id="18256968"/>
    <dbReference type="KEGG" id="cthr:CTHT_0029300"/>
    <dbReference type="eggNOG" id="KOG0889">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000129_1_0_1"/>
    <dbReference type="OMA" id="CLDLYGQ"/>
    <dbReference type="OrthoDB" id="5570127at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05163">
        <property type="entry name" value="PIKK_TRRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046807">
        <property type="entry name" value="Tra1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046805">
        <property type="entry name" value="Tra1_ring"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF1">
        <property type="entry name" value="TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20175">
        <property type="entry name" value="Tra1_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20206">
        <property type="entry name" value="Tra1_ring"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAT" evidence="6">
        <location>
            <begin position="2706"/>
            <end position="3261"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="5">
        <location>
            <begin position="3538"/>
            <end position="3864"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="7">
        <location>
            <begin position="3861"/>
            <end position="3893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="187"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1267"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2063"/>
            <end position="2095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3270"/>
            <end position="3362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1273"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2085"/>
            <end position="2095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="3325"/>
            <end position="3351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS21089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3893" mass="444093" checksum="730DECEABFD947CB" modified="2011-10-19" version="1">MATSLIEDVVKKLSVAETGTGNSLSERSLLVLPLMQVSCYTELKVKAEAACALRDSLDHYTAGPAYPAFLKKVMPVFIHILRQQPVFQTTGEQGHMQKLRNCILEILHRLPTSQTPPEHFEPYAHEIVDLLLELVRTDNEDNVILCVKILSDIMRHQHKIMSGKVQTFLNLIQELFEQLDKVVRDQLDNTSTTGPPGPPSTPGSTQSSFLPHQQSPRPGSPVTTGVTDFGADANQQANRLLPRGMYSFKVLAECPIIVVSIFQVHRSAVTPNVKAFVPLIKSALLCQAKAQDQAHREAAARGTIHIGVSPNIKNRAAFGDFITAQVKTMSFLAYLLRQYSSQLSDFLPHLPDIIVRLLRDCPRDKSSARKELFVAIRHIINFNFRKIFLPKIDELLDERTLVGDGLTVHETMRPLAYSMLADLIHHVRDQLSPEQIRKTVEVYTRNLQDNFPGTSFQTMSAKLLLNMAECIARLPNKVDARHYLIMILNAIADKFAAMNRQYPNAVKLSKQYAQQAAKNVPETYLADKENPPDWDEIDIFNATPIKISNPRDRAADPVVDNKFLFRNLMTGLKNTFYQLKSCNIPGAVDLTGAPAHWTDVAYGFTAEEVKVIAKLFREGAYVFRYYEIEKPAAESPYSSPVEYMANFYMVSSSKEEKELLETFATVFHCIDPATFHEVFQQEIPRLYEMIHEHTALLHIPQFFLASEATSPSFCGILLRFLMERIEDVGSADIKKSSILLRLFKLAFMAVTLFANQNEQVLLPHVVDIVTKSIELSTKAEEPMNYFLLLRSLFRSIGGGKFEHLYKQILPLLEMLLDVLNNLLMAARKPAERDLYVELCLTVPARLSNLLPHLSFLMRPLVVALRAGTELVGQGLRTLELCVDNLTADYLDPIMAPVIDELMTALFDHLKPHPYSHFHAHTTLRILGKLGGRNRKFMTEALPVTFQQYVDDRASFDLRLIGSKRDRAFPAHLGIDLAIQKLTEIPKPVKGGVPQLSRQYDPYYKRQALNLIIAQTKLRVGFDSVPEDLPRLVRLQVEDLVKKNRDVDISLFEVSDKERSIAKKNEEQALLKRLLKALLYAESIPEFKQEVDALLVNLARHFTLIEIGRSVIDMKKAYTPFDTKSGEGPLFIDNRVLSEAILESLANENLEVREAAKRLIKEMHNAAVTVFGSPMHVPRMTFWSSLASTFCHGCYEEEWFTKQGGALGIQTLLTEIDLGDLWVAAKQIEFVRALMYVVKDMPQDLPEKTRRTAQVTLEQLLARITRNAKKQDCLPPPPPPAPPGSHPPQPPPRPPRLAQLVMMLNSELAHMNRHVRATARRSIEAIAAAAQAEVWELLEPHKKHILGPIYAKPLRALPFAIQIGYIDAVTYYMSLKRDFVPFDENLNRLLMESLALADASDESLAGKTLEFRTHDFIVNLRVSCIKILSRAMSFEEFGSGSNNPTRPKVVSVFFKCLYSDSQPTIDAANDALKAVLQHTTKLPKDLLQSGLRPVLASLQDAKRLTVHSLDNLGRLLRLLTTYFKVEIGTRLLEHVKQIADPNFLQQLSFTFFEQNNAMKVIAAVFNIFHLLPDAARQFKERVIDNVLDLEQKLRRTHHSPFRLPLYKYLNKYPSDIWAFTLQKLEDLRYGRFLAQVLRHPDSQVLRDYGAANVEFIIKTCNTVVVSGKETKFIAIINTINMLDALCQFPTANSQSWLDNKEHIEWLKTVGKELELQQKKNSLTPNLRLPAHQASEQLMNILTKALDRNPNDLDALFSLVEGITSDDFRETPALLSHIYNKIIRSDSIDFWRITILRCLDIYSGKTASQRMKWYLLHNIVNPIIAMDVMRTWDDPNKASRLLDRTVIDSINTKIWKVNLPDPQEDLLQPRVDHTRMEVLQLSAMLVKYRHALLQDARKDFIKFAWTYIRLDDVINKHAAYVVIGYFIAHYETPAKIVSQIYFSLLKTNQNEGRALVTQALELMAPVMPKRCPFPPGDRNPVWALAPRRILAEESQNVQQMTAIFHYLVRHPDLFYDTRDKFAMLIIQCLRKVASPPNPSNDNRKLALNMMWLIWQWEQRRVESKLSEPLRAPSESPNSNKRKLDEQQGLSPSATRQAEFQIPSVGRHKMIRYLVEFIAQLNERYPLPSARPSDPPTTTSFLLPSPSNELCKKATALLYNLLQPQYWGDLVEEMDLFPNVTDLVLAGEKSATLLSADPSDPEKCDDKLITSIINTLQVVRIVLHFKSDRWILDNMPQIQKILEKCLKSANPEIQDCLHMADRKYDGDRDVKPTIKRILDAVPEDIPMEDADGDIEPESQTSELIAWLSGIATESMAAGNYVSGINILWSLGHRKPSIIDQHIPAIMRSLQSKLARDHVSHYAALGHQASGLRPQADPNAPTEMKAYDLEIQTNLILKAIEVTAMRMEILGDNRRPFLSVLATIVEKSLHIPLCEKILEMVEGWVFRSEGTWPTLKEKTAVLHKMISFEHRTDPTMLHKFLNLVLRIYEDPKITRTELTVRMEHAFLIGTRAQDVEMRNKFMSIFDKCLSKTASARLAYVILGQNWDTLADSYWLAQASQLLLGAVDMNPTIQLHQDDFRTLPISQLVAPYAKDSREPSVMIDDKFEAFMANHRRFLAELGDVRARDVLEPLMQLQHIDANFAHELWVALFPMFWSAVPKEDRPDLERGLVTLLTKDYHSRQMDKRPNVVQSLMAGAVKTWPHCKIPPHVLKFEAKTYDAWYTALHQLENAAIKPEIDSAAVRESNLDALVDLYSTLGEDDLFYGTWRRRCQFVETNAGLSYEQHGMWEKAQRMYESAQIKARTGVIPFSEAEYMLWEDHWVLCAQKLQQWEILQDFAKHENFQDLLLECAWRNTEYWQNQENRDQLDTVIKGVMDAPTPRRYFFQAFMSLLKLHNKQETPQDFNRVVDEAIQLSIRKWHQLPKRLTAAHVPLLQNFQQLVELHDASVICQSLAQTNASNLDVKSGELKLLLGSWRDRLPNMWDDIVAWQDLVTWRQHVFGLINATYLQLIPQQAQNAGGASFAYRGYHETAWIINRFAHVARKHALPEVCISQLSRIYTLPNIEIQEAFLKLREQAKCHYQNPDELTSGLDVINNTNLNYFSAPQKAEFYTLKGMFLEKLGQKEEADTAFGTALYFDITAAKAWAEWGYFNDRKFKENPSDLPSAKQALTSYLQAASSYKNHKSRKLIARILWLLSLDDANGTIAAGFDDFKGEIYVWWWIIFIPQLLVGLGYKEAPRVQAILLKIAKTYPQALYFLLRTNREDMLTIKKNQEAKERARQRAAQAAIPNKPNGSPQLTKKDGAAGAADGRPPTANGETPKPPEIKIEGAAPNAPTAATPQAAANAPQVPGAAPAEQQTGGVQKKPPWELTEEIMSVLKTAFPLLALSMETMVDQIQKHFKCPPDEDAYRLIVALLNDGLSYVSRMPASYAKDVKLPAATENNITRFAETILPNHIRPTFEADFVKVKPTMYEYIHNLRKWRDKFEEKLDRRASPAPLESFAHYSPHLSEFRYQKFDDVEIPGQYLQHKDKNQDFIRIDRFLPNVDLVRTIGASHRRLRIRGHDGSVHAFAVQHPAARHCRREERVLQLFRQLNQTLANKKESRRRDLQFTLPLMVPLAPHIRIVQEDTSYITLQSVYEDHCRRHGMNKDEPILFTMEKLRGLMDAKALQKPEQAVTAKLEVYRAIQEKFVDHTIVLEYFQGAYPNFADFWLFRRRFSYQLAALTFMTYTMHIDKRYPHKMNIARGSGNIWGSEAVSYMAPSRPLFQNTEPVPFRLTPNLQTLMGPLATEGIFAASVMAIARCLTEPEQHLEHALTLFVRDEMMFWFTNSHRTMSLTENQLRETVQANCDMIVKKALALAQTPQGNLPAHQTVTDLIAKATNPMNLALCDALWMPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0S850</accession>
    <name>G0S850_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0029380</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the 2nd section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the shikimate kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693393.1">
        <property type="nucleotide sequence ID" value="XM_006693330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S850"/>
    <dbReference type="STRING" id="759272.G0S850"/>
    <dbReference type="GeneID" id="18256976"/>
    <dbReference type="KEGG" id="cthr:CTHT_0029380"/>
    <dbReference type="eggNOG" id="KOG0692">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008871_0_1_1"/>
    <dbReference type="OMA" id="FTHAIFV"/>
    <dbReference type="OrthoDB" id="4415835at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000386">
        <property type="entry name" value="Quinate repressor protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090">
        <property type="entry name" value="AROM/DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090:SF17">
        <property type="entry name" value="QUINATE REPRESSOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="5">
        <location>
            <begin position="467"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase" evidence="4">
        <location>
            <begin position="600"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="654"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="654"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS21097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="838" mass="93733" checksum="7A5F04099BFE6A26" modified="2011-10-19" version="1">MPRNERLFDPNASIVLVGCRGAGKRTLGFMGALHLRRRLVTEDHFFEKLTGLTRGDYLARHGREQFARTNMDVFRKMLESNSTGCIIECGMSSLAEEAQEMLREYSKTHPVVYVHREPEQITRLLDPDDAAQLLQADARHRACSNYEYYNLYDSTTAYDSSSPASRAASPTGLRQPGPSKLLCVQEDFARFLDIITGRGATKAWLESPFSVAAIPPEFRSYSYALRLRLSYLVDMDLDWEDFEAKGDCVELIIDHWPGDMVNVIARQVALIRRKLRVPIIYHVEENPRGERRRSQEERDSMDSELLELGLRLAVDYISIDLQRSDALIDRALRRRGRSKVIGNYCYMGFGALPWQDDRQLENYRRAQSLGCDIVRMMRFCTNDSPVEYLEEFKKRLNEAIPEPKPPLVAFDFSILGVRTPLQTRILGPVKHPDMENEREHLATVTTAQHSFRQLFHQFLLDPLNFYVLGSNVSYSLSPAMHSAAYDATGMPHTFQAVDISTLDQLNAICSADSFGGASLTAPFKVAVMPHLKVKSAHANAIGAVNVLLPLRGRTPAILDHANSRNKAGPAREFYGDNTDWSSILTCLRRAISPRNHVQPSRTTALVVGAGGMARAAIYALYQLGCRNIFVYNRTVANAQAVAAHFNSWAAQQQQQQQQQQQQQQQQQASSNIPTVNGHVGGGNREIVRVLGSLTDPWPTGFQQPTMVISCVPATVGPDGEPPADFVMPLDWLRSPTGGVVVELAYEPLVTPLVAQMRSLAARASPQSPQLSSSPSSNGNGINATNWVVVDGLEVVAEMAIEAFELMTGRMAPKRLMKEVCWKGWEAQQLERRTQRQQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0S874</accession>
    <name>G0S874_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">COP9 signalosome complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0037820</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M67A family. CSN6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694204.1">
        <property type="nucleotide sequence ID" value="XM_006694141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S874"/>
    <dbReference type="STRING" id="759272.G0S874"/>
    <dbReference type="GeneID" id="18257820"/>
    <dbReference type="KEGG" id="cthr:CTHT_0037820"/>
    <dbReference type="eggNOG" id="KOG3050">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027018_2_0_1"/>
    <dbReference type="OMA" id="LVGWWST"/>
    <dbReference type="OrthoDB" id="1378at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08063">
        <property type="entry name" value="MPN_CSN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033859">
        <property type="entry name" value="MPN_CSN6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF8">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="MPN" evidence="4">
        <location>
            <begin position="22"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="241"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="263"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS21908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="475" mass="51683" checksum="941E9359644F3786" modified="2011-10-19" version="1">MADQAVNELLSTQKADALGLQVVLHPLPVLEISDYIARAYQRGLQGAVVGALLGQQDGHQVTIEFSFSCKTVKNDEGLFELDQEWFKQRLEQMRTVHKNPPLDLVGWYSLVPKTGPTRYHLPIQRQISAVNDSAILLGFHVEDIINPAPGDPLPITIYETLMEAEESRENDGEDKEMMDVEAAAKMVLRFRKLPYVTDTGEAEMIALKYIREGGANATAEPSDRSMVEQFEKKIAVDDGKGKRRAVAYEESSQAKKEASSSATNTPTNEQQQQSNPDVNLNREETEYMSALQAKYNAIKMMKSRLALVIAYLAQLPPAFKQGYQTTANAAADARATHGVHTIPSNTILRQLQALLTNADLVTPSTTSPSDSQPSALAQELQREANDVQLISLVSDLLSSVSEIREAGKKFSVLEVARMQRQMGRADPRDGGGGFGDMEFDPRMLLGGRRGGGGFGGMEGVGGPGFGSSSAAAAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8A4</accession>
    <name>G0S8A4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0038120</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GILT family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694234.1">
        <property type="nucleotide sequence ID" value="XM_006694171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8A4"/>
    <dbReference type="GeneID" id="18257850"/>
    <dbReference type="KEGG" id="cthr:CTHT_0038120"/>
    <dbReference type="eggNOG" id="ENOG502S45F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072148_0_0_1"/>
    <dbReference type="OMA" id="KLNYIGT"/>
    <dbReference type="OrthoDB" id="958254at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016671">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004911">
        <property type="entry name" value="Interferon-induced_GILT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234">
        <property type="entry name" value="GAMMA-INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234:SF8">
        <property type="entry name" value="GAMMA-INTERFERON-INDUCIBLE LYSOSOMAL THIOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03227">
        <property type="entry name" value="GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS21938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="211" mass="23629" checksum="94BA947D77E60AC7" modified="2011-10-19" version="1">MPPMRRGPSSRLVRITAVAFFIGLYLLACYYIDPRGVFHKEPDFDEFEEELPKKSTPVKSQTLVPLEAHIMSKCPDARDCLRDLVLPTMVRVHDKVNFTLSFIGTPTDNDGVACKHGPEECLGNIIELCAQKLYPEPKAFLGFTMCLTRDYKHIPQRSLIEDCALEHALDFNALNECATRENGAYGVGMLRDSVQRTANVSCGLGYLQITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8H2</accession>
    <name>G0S8H2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0029870</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:16638"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693442.1">
        <property type="nucleotide sequence ID" value="XM_006693379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8H2"/>
    <dbReference type="STRING" id="759272.G0S8H2"/>
    <dbReference type="GeneID" id="18257025"/>
    <dbReference type="KEGG" id="cthr:CTHT_0029870"/>
    <dbReference type="eggNOG" id="KOG2571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012773_0_0_1"/>
    <dbReference type="OMA" id="NCIHVFL"/>
    <dbReference type="OrthoDB" id="5321960at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000077">
        <property type="entry name" value="Probable chitin synthase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF46">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="441"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="502"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="580"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="773"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="773"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="830"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="849"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS21146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="865" mass="98022" checksum="549CB0364C227767" modified="2011-10-19" version="1">MAADNNQEWPVHEIVYTAIVGVLMLAALLEWFLWIAAFLYCLYKVFVKAEHWTVRVLAVIVAIAFTALRLIFLPIMVVTLPLPKQITEMWPKEMVSFLQWFAFWSFSGLLVIPWLMCVYQIVTNQLGRTKRIKQVLDDVSAPKVVIVMPVYNEEPDVLITAINSVVDCDYPPACIHVFLSFDGDEQNELYLRTIERLGVPLTLENYPKSIDVTYKNARITVSRFPHGGKRHCQKMTFRLIDRVYKEYLRRNDNLFILFIDSDCILDRVCLQNFVYDMELSPGNKRNMLAMTGVITSTTRKHSLITLLQDMEYIHGQLFERTVESGCGAVTCLPGALTMLRFSAFRRMAKYYFADKAEQAQDLFDFCKNHLGEDRWLTHLFMIGAKKRYQIQMCTSAFCKTEAVQTMRSLVKQRRRWFLGFITNEVCMLTDWRLWRRYPILVLIRFMQNTIRTTALLFFIIILALLTTTKRVEELPIGFIAISLGLNWLLMFYFGAKLRRFKIWLYPLMFVLNPFFNWYYMVYGIFTAGQRTWGGPRADAAAADAHTTAQQAIEKAEQAGDELNIVPESFIPAARERQELARAAKKGKGKDKEAAGDGSSTDDLKKPRPTPVPSTISSGPGATLLPPDKIIGRFAAPERTASGWFLHPNDSMASIAATARNGSYYNHPHYQQAYPGSYLSTADGNGITADPSELKPPSFLSHYRRDSIDSTISAQTGISMSMYMPQRVENIMGEEDRKKYELAMQAQAHDSYHSAFSASDHALHRWSEWTPLHGSGGVGTNGSGHGNGRDRSPQGRVYEVGSEPIDSLTPPSPIPPLNAAVGGTHGRSPLSRASWTRTSSVEDVEREIMGQQQQSRPGSSRSAKQR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-06-24" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8I1</accession>
    <accession>G0ZGV9</accession>
    <name>NUP56_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleoporin NUP56</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Nuclear pore protein NUP56</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">NUP56</name>
        <name type="ORF">CTHT_0029970</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 8">The nuclear pore complex (NPC) constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. The 55-60 MDa NPC is composed of at least 28 different subunits: AMO1, ELYS, GLE1, GLE2, MLP1, NDC1, NIC96, NSP1, NUP133, NUP145, NUP152, NUP159, NUP170, NUP188, NUP192, NUP37, NUP49, NUP53, NUP56, NUP57, NUP82, NUP84, NUP85, POM152, POM33, POM34, SEC13 and SEH1. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Nucleoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited. FG repeat types and their physico-chemical environment change across the NPC from the nucleoplasmic to the cytoplasmic side.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JF276305">
        <property type="protein sequence ID" value="AEL00697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693451.1">
        <property type="nucleotide sequence ID" value="XM_006693388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8I1"/>
    <dbReference type="SMR" id="G0S8I1"/>
    <dbReference type="STRING" id="759272.G0S8I1"/>
    <dbReference type="TCDB" id="1.I.1.1.2">
        <property type="family name" value="the nuclear pore complex (npc) family"/>
    </dbReference>
    <dbReference type="GeneID" id="18257035"/>
    <dbReference type="KEGG" id="cthr:CTHT_0029970"/>
    <dbReference type="eggNOG" id="KOG0866">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044364_0_0_1"/>
    <dbReference type="OMA" id="LFKGMRC"/>
    <dbReference type="OrthoDB" id="185618at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF142">
        <property type="entry name" value="RAN-BINDING PROTEIN 3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0509">mRNA transport</keyword>
    <keyword id="KW-0906">Nuclear pore complex</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000433183" description="Nucleoporin NUP56">
        <location>
            <begin position="1"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="repeat" description="FG 1">
        <location>
            <begin position="223"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="FG 2">
        <location>
            <begin position="226"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="FG 3">
        <location>
            <begin position="237"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="repeat" description="FG 4">
        <location>
            <begin position="247"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="FG 5">
        <location>
            <begin position="266"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="repeat" description="FG 6">
        <location>
            <begin position="312"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="repeat" description="FG 7">
        <location>
            <begin position="328"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="RanBD1" evidence="4">
        <location>
            <begin position="377"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="247"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="300"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="345"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Nuclear localization signal" evidence="5">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="114"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="248"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="332"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P32499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q9USL4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="7">
        <source>
            <dbReference type="PubMed" id="21784248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="8">
        <source>
            <dbReference type="PubMed" id="21784248"/>
        </source>
    </evidence>
    <sequence length="524" mass="56173" checksum="BDE295E33FFEA802" modified="2011-10-19" version="1">MADDPHNTSTSDVSELVPDNTEPSAANVKEDAETTAARRELKQTTISDKAKRDSAQLSQEDDKSASEEDDNKSDAGEPEKKKPRTSRGLTPEVQLAAPKQEVPKETVASPKKRTHDELEQDGKEEEEKKEGEKPSSQNRAERDEPEKKRPRDRQASLSVERDGQKEVEPLSAQESRPSSAEKPKIEEKKDESKDTKVDKPQTSSSAFANSSMAKFASSTTSPFGAFGAAAAGKTNLFGLPATSSNIFGSKSADASAAPAGPPKLSFGSASAASPFASLNGQAGGMSSLFKSPFASAFSGGSSALKTAGATGFGKPGEPLKTGKSAKPFGAPESDEEDEGEGEEGEENKSENGEGEEKEEEEKEEKASGEEKKKFKLQKVHIDDGEGNETTLLSVRAKMYVMEKGVGWKERGAGMLKVNVPKQAVEVEEGNQPDADSFDPAALDDAARKLVRLIMRQDSTLRVILNTPILPAMKFQVNHKLKAATVLFTAFEGGEARQVQMKMSQANATQFSNMVEKIKEKLAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8U5</accession>
    <name>G0S8U5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL6m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0043460</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694741.1">
        <property type="nucleotide sequence ID" value="XM_006694678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8U5"/>
    <dbReference type="STRING" id="759272.G0S8U5"/>
    <dbReference type="GeneID" id="18258384"/>
    <dbReference type="KEGG" id="cthr:CTHT_0043460"/>
    <dbReference type="eggNOG" id="KOG3254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065464_1_0_1"/>
    <dbReference type="OMA" id="RERHGLC"/>
    <dbReference type="OrthoDB" id="540873at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000001">
        <property type="entry name" value="50S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000009">
        <property type="entry name" value="60S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_uL6_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_uL6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL6M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8 11" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="10">
        <location>
            <begin position="88"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="10">
        <location>
            <begin position="161"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS19856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="257" mass="29171" checksum="FA452AF67F0068C0" modified="2011-10-19" version="1">MLAPRTTASGLRQALGRISTPTTSSTTTTQTLLQRTTPLLSQRRNFSVTNVQQSKLGRTPITVPPGVELQVSDLYVKKDMTSYKKEYKRRITVKGPLGQLELEIPDFVNVNQDPETRQVRLTVADRNERRQREMWGTTWAYLNNYIMGVSEGHTAVLRLVGIGYRATVESRPDLEEYPGQQFVSLKLGFSHPVEMGLPKGMKASAPQPTRVLLEGIDKEQIMQFAANLRKWRKPEPYKGKGIFINDETIKLKQKKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8Y2</accession>
    <name>G0S8Y2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0043850</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694778.1">
        <property type="nucleotide sequence ID" value="XM_006694715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8Y2"/>
    <dbReference type="GeneID" id="18258423"/>
    <dbReference type="KEGG" id="cthr:CTHT_0043850"/>
    <dbReference type="eggNOG" id="ENOG502R7EN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095380_0_0_1"/>
    <dbReference type="OrthoDB" id="5242940at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="309" mass="32380" checksum="F29917E40AEAAC07" modified="2011-10-19" version="1">MPVIYEGRSERGTYREIKVPKGSKSVSAILYFAGRDPRRVKAIRKYIDEDEDHQTVHSGSDSILSWMTSSSGSSNIWLVESRYPDWMYGSARDDESVTSSRSSHSSRSRRRSSTSPSSSSGKHSHNHYHRTTPVPPMPYPPGMSGIRPMPMPTSTWPRGVPTAHPHMQTTTAIPIPEDYDEDDDVSSESSASSIDDDYPAPNPAPNGPTGGSVPGFVAVPGPAPGQEQGVASAAAAAAAGQFRHPVYGNVPRTVPGVISGAAAGRPGMPPPGIVGAGAGAASVPPPPPPPPGAAMPPPPPGFRPGTAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G0S918</accession>
    <name>G0S918_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">T-complex protein 1 subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0044220</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694814.1">
        <property type="nucleotide sequence ID" value="XM_006694751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S918"/>
    <dbReference type="STRING" id="759272.G0S918"/>
    <dbReference type="GeneID" id="18258460"/>
    <dbReference type="KEGG" id="cthr:CTHT_0044220"/>
    <dbReference type="eggNOG" id="KOG0357">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_7_2_1"/>
    <dbReference type="OMA" id="SHPQMPH"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03339">
        <property type="entry name" value="TCP1_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000003">
        <property type="entry name" value="T-complex protein 1 subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012718">
        <property type="entry name" value="Chap_CCT_epsi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02343">
        <property type="entry name" value="chap_CCT_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS19929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="551" mass="60107" checksum="E462A45D17F665BC" modified="2011-10-19" version="1">MGSMNIDLSNATVMKDEQGRPFIVVRDQGKKKRQHGNEAVKAHILAARTVANIIKTSLGPRGLDKILISPDGDITVTNDGATILQQMEITNHVAKLLVELSKSQDDEIGDGTTGVVVLAGALLEQAAELIDKGIHPIRIADGYDQACDIACAELDRISDVIEFDRENTENLIKVARTSLGSKIVSKAHDQFAKIAVDAVLSVADLERKDVDFDLIKVDGKVGGSLEDTMLVKGVIIDKDFSHPQMPSEVRDAKIAILTCAFEPPKPKTKHKLEISTVEEFKKLQNYEREKFVEMIQQIKDAGANLAICQWGFDDEANHLLLQNNLPAVRWVGGPEIELIAIATNGRIVPRFEDLRPEKLGTAGLVREITFGTTREKMLVIEECANTRAVTVFVRGSNKMIIDEAKRSLHDALCVVRNLVRDNRVVYGGGSAEVACSLAVEDAAVKTPGLEQYAMRAFAEALDTIPMTLAENSGLNPIATLAEIKSQQVKDPAARGRVGVDCMGTGKNNMKEAFVIDPLIGKKQQLMLATQLCRMVLKVNNVIVSGSGEEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>G0S972</accession>
    <name>G0S972_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0044790</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694868.1">
        <property type="nucleotide sequence ID" value="XM_006694805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S972"/>
    <dbReference type="STRING" id="759272.G0S972"/>
    <dbReference type="GeneID" id="18258517"/>
    <dbReference type="KEGG" id="cthr:CTHT_0044790"/>
    <dbReference type="eggNOG" id="ENOG502S5RK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008828_0_0_1"/>
    <dbReference type="OMA" id="DEIGIMY"/>
    <dbReference type="OrthoDB" id="3971593at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="206"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="64"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="279"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="348"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="804"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="64"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="286"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="824"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS19983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="973" mass="104909" checksum="C3D93563BE0A5043" modified="2011-10-19" version="1">MDQLETQVSDLRSFLGAAAEAGPQSVRPGAAEIMSPLASGFGVNVAYSAAPSASVSGTEIGPGADGPLAAGGSIPGSSGLRRGSSYSGRSTAPTAGVAVSAGPGARSARGSLSSSSAAPGDNSAPNAPTILPSLPTLPALPTAAGTPPQQPPSPLEARANSVTSAASVSGSVSAAATTAKRRAEDGDGEPVVKQQRSKRNRYISIACNECKRRKIKCNGQTPCQRCGHLNLQCLYAPNCCSTFRESEEFKRLTEQVRQLQEHVNTLFNEMNALKQETMLRSGQDRGVVASPAGSGPGGASTLAPTPSSSSRQPSQAQPLPYRAPSTFHGPTSIAYTVDVAKNTLQNMGVADRDDSSGPQSASTPHGSPGLQPLTGAAPSPGYSQADGGERDPLWEFDEPEMMRLLYVFRDEVSFMWPVVSPDAIFEHAKQVCLWMSARRRDPAGGGDPVEQQKLFKDPQTLLLKLALCSGLLIEEHGNSPKADRLFASIQPIVDRMLMSEHADVNTLPILALVASYRYLSNDEVLAWRVIGHIARMCLELGLHRLEGLKRIADKQARKHALHTFWTTYILDRRWSFATGLPFVFHDDKIDPKLPYPNQHPFLVAMIDYSKLSAKIWKFVDYFEPAVTRELKPQDFELLDREIMAWYDSVPEEIRIDPQLDDDEIPLQASHRQRIWTRLRLNQARIWLYTPVLHSATSIAQNLEQAQKVVELAKKTICILTRLNQKTDLYRRMQVFYHQFLTSSIAVLFLASTHAPLQFSGMCRDEFYMALDLVKEMSARSWVSKRLWRTIKSLKAYAPSLGLDAGREHRSSSGVFPIGSAKGVQSTTSSQSPDSASHAGSAFGGTLPPGHHHSSPTPVHVTQAPILPSQSQILASSGDSPSDGVQLHTEMSRIFEGYIGFGMGSHVGGLGINMVSSAPGDAAGYSSAPPVTGVSTPDVEMVYAPPPQADGLGIGMDEGNEPGQGVYMHVREMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9B1</accession>
    <name>G0S9B1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Distal membrane-arm assembly complex protein 1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0045190</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694907.1">
        <property type="nucleotide sequence ID" value="XM_006694844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9B1"/>
    <dbReference type="GeneID" id="18258557"/>
    <dbReference type="KEGG" id="cthr:CTHT_0045190"/>
    <dbReference type="eggNOG" id="ENOG502SWTT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159478_0_0_1"/>
    <dbReference type="OMA" id="KSIFGMR"/>
    <dbReference type="OrthoDB" id="6604875at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028036">
        <property type="entry name" value="DMAC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053092">
        <property type="entry name" value="Mitochondrial_unc_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28048">
        <property type="entry name" value="ACR195WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28048:SF1">
        <property type="entry name" value="ACR195WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15055">
        <property type="entry name" value="DMAC1_Dmo2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Distal membrane-arm assembly complex protein 1-like" evidence="2">
        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS20022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="95" mass="10502" checksum="41520E391A37636C" modified="2011-10-19" version="1">MAKDIPSIHALDKPERLEDLLRQDRGDDCLGCRIVGGGAFLGLAAYSYFSGHSQLEKQQAQILASGSRFGMRSRRLGINIISLSLAWLGVWRLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9C6</accession>
    <name>G0S9C6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0045350</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694922.1">
        <property type="nucleotide sequence ID" value="XM_006694859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9C6"/>
    <dbReference type="GeneID" id="18258573"/>
    <dbReference type="KEGG" id="cthr:CTHT_0045350"/>
    <dbReference type="HOGENOM" id="CLU_1272142_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="217" mass="23718" checksum="B234F1E49F35454F" modified="2011-10-19" version="1">MSSPSSVTQGSLRRRARVVNRSRQGQQPSASAASGNTETTLTANSTGATSVTKAGDRAAVDLPAASVQPESPVDVQSSTDTNVGAASSSRRPLPTIENDYIPQWGRELWHQRARERARAEELRRGKWSDESKTMLLAYLAKGYTIHEIADFEKRTPEECYREAHKIGKIYNDKALLNKLEAIKGNLEVTDDDEEGNGKNYWEVHGVSPGPNRGPGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9D8</accession>
    <name>G0S9D8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular serine-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0045490</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694934.1">
        <property type="nucleotide sequence ID" value="XM_006694871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9D8"/>
    <dbReference type="STRING" id="759272.G0S9D8"/>
    <dbReference type="GeneID" id="18258587"/>
    <dbReference type="KEGG" id="cthr:CTHT_0045490"/>
    <dbReference type="eggNOG" id="ENOG502SQA8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053381_7_1_1"/>
    <dbReference type="OMA" id="WYYCAQQ"/>
    <dbReference type="OrthoDB" id="5415867at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF15">
        <property type="entry name" value="EXTRACELLULAR SERINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408921" description="Extracellular serine-rich protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS20049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="21675" checksum="D1831B91DD14509C" modified="2011-10-19" version="1">MYFTTLTTLLTLAASALAAPAPAPTYHNWPGAPTKTYTAPRITHTVVAGRGGQLRFDPENVVAEVGSIVEFHFLPANHSVVEAAFNAPCRPRSDVDPAAPNSFFSGFFPVTPNPDGSLCQSEEVFQIEVKDDKPIWYYCGQPGGGGHCQRGMVGVINQRFDTPFTLEKFRQEAAKVPPPPGLPAGGVRGGWRIPNPNPLGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9G5</accession>
    <name>G0S9G5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0045800</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694961.1">
        <property type="nucleotide sequence ID" value="XM_006694898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9G5"/>
    <dbReference type="GeneID" id="18258618"/>
    <dbReference type="KEGG" id="cthr:CTHT_0045800"/>
    <dbReference type="eggNOG" id="ENOG502T26A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067171_1_0_1"/>
    <dbReference type="OMA" id="REYPGGW"/>
    <dbReference type="OrthoDB" id="4359806at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408970" evidence="2">
        <location>
            <begin position="19"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS20076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="321" mass="36399" checksum="75E89B7E41C7217D" modified="2011-10-19" version="1">MKFTPLLAAALLTGSTTAIGPATPDQPPRLKGKPEKMSNWKWPNPFTSSTVTKKYDPVCTVERIIAAQEYLLDDLSQNPPKGLLPYRDALKSVFGTRDYPGSWDGIDPHGYDRHILFMDYHLMPLKVREWIEDQERSDGPGKGLFAVYPRPLPGTRVLHTVKVPQESPVPKEWRENDDRRVALFAPGAIYETLPLWVADDSDCAEALSDLSRYSAKPKNGGVIAYPVKHTSPNRGANERDMEITIKAQVLTLKPGETEEVEPEAKKEEKIEKKEETKEEKVEEKEEDTKTEEKPTEKTEEKAEEKTEEKKEEAKVDEKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9T6</accession>
    <name>G0S9T6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CTHT_0047120</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695082.1">
        <property type="nucleotide sequence ID" value="XM_006695019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9T6"/>
    <dbReference type="STRING" id="759272.G0S9T6"/>
    <dbReference type="GeneID" id="18258750"/>
    <dbReference type="KEGG" id="cthr:CTHT_0047120"/>
    <dbReference type="eggNOG" id="ENOG502S1H2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081622_0_0_1"/>
    <dbReference type="OMA" id="CINTCVE"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF1">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 18" id="KW-0732">Signal</keyword>
    <keyword evidence="17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408934" description="CFEM domain-containing protein" evidence="18">
        <location>
            <begin position="19"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="19">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="97"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="152"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="152"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="54"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGS20197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="275" mass="28906" checksum="FE89077E44D07413" modified="2011-10-19" version="1">MVAIRSLPFLALAAYVSAQSIDTLDPCGRECYQNAVAQWGHFGCTSADDTACLCSNVDFHNAIDSCASGVCPPGYGPNVVAAANNFCAAFTAAPSPAPTTTEATEAVEPTPEPTPTEAAELTSTSEQATSNASSTTFVTSTSVNVAVATQKATETTSNAVPTATADGSETPDDDDNKSSSTAGLTRAAKVGIGVGACAAFLAFLGLAGFFYFRSRRAPEEPATNLRYKISGPMPNAEHQQTYNIRNSEYDIGNELEANSRRYEDMLPREKPREMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G0SA96</accession>
    <name>G0SA96_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar calcium ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0041470</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694553.1">
        <property type="nucleotide sequence ID" value="XM_006694490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SA96"/>
    <dbReference type="STRING" id="759272.G0SA96"/>
    <dbReference type="GeneID" id="18258185"/>
    <dbReference type="KEGG" id="cthr:CTHT_0041470"/>
    <dbReference type="eggNOG" id="KOG1397">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008721_2_1_1"/>
    <dbReference type="OMA" id="WIANFTE"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00846">
        <property type="entry name" value="caca2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF22">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 10" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="399"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="12">
        <location>
            <begin position="149"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="12">
        <location>
            <begin position="337"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="49"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS19668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="493" mass="53081" checksum="810197D08D6DF606" modified="2011-10-19" version="1">MPNYLARATVFSQRLFMDIENKQAQQAMLFQQSHLDFLHHPATTAIIVDKDASRSRRSSAPYGTSGTPHHTMNHDVESGPANEADERRALLPRGGTSSTGSSDTQVEEHGFWYRLLVDTDNTPGFESRNLLPKPLGLLAGHLEWSTGSIFWLNFIAILPLASILSRATEDLSGHLGATLGGLLNATFGNAVELIVSIIALSAGELEVVQASMLGSILSNLLLVLGMCFLLGGLTNMKDKDGRGIEQTFAHGNAQITGSLLALSCASMIFPAVLYGVLDQSDAERDKTVLMLSRGTCVILLLLYCLYLVFIMHTHKELFSEDKDEDEVTQLGPWEASILLLVTTLIISFCADYMVETIDALAASGKMSKTFIGLILIPIVGNAAEHAAACTMAIKNKMDVAMSCAIGSGIQIALLVTPALVMLGWAIGQPLSLHFETFQTVAFALSVLVVTYTVQDGRSNYLEGAMLLGLYCIIALAFWASPGDALGKGSIPWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAC7</accession>
    <name>G0SAC7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G1/S-specific cyclin pcl1 (Cyclin hcs26)-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0041810</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694584.1">
        <property type="nucleotide sequence ID" value="XM_006694521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAC7"/>
    <dbReference type="STRING" id="759272.G0SAC7"/>
    <dbReference type="GeneID" id="18258219"/>
    <dbReference type="KEGG" id="cthr:CTHT_0041810"/>
    <dbReference type="eggNOG" id="KOG1674">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018149_3_0_1"/>
    <dbReference type="OMA" id="HNVIACD"/>
    <dbReference type="OrthoDB" id="10250320at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF10">
        <property type="entry name" value="PHO85 CYCLIN-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="2">
        <location>
            <begin position="72"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS19699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="432" mass="48649" checksum="F495D36656E43EF2" modified="2011-10-19" version="1">MEPYQELSFEELNRRALHEFIYQPVSRDMIKYLAKAASNVIQCDPNMAPPSTTRFSSSGKPVPASDGLPSVEDFITKLVISSNVQVPTLMSTLVYLTRLKQRLQPEAKGLRCTIHRIFLATLIIAAKYLNDSSPKNKHWANYTVMQSPHYHFGFTRQEVNLMERQLLALLSFDLRITEEDLYQEFEPFLAPLREKIATHRRERYERKLRQQQYLQEQQMRIQQQRHQNDEFLTVPVQPSLSPEHTYPTPPSSRGSSCTRSPYHSRNPSSVSGHSRSSSRSVTPPDLVSSGASSYAPSVASRATTPCEDEPAPEIQVVDSPEQVSDLHCEDVAPPKVPAKDYYNSTYKPAAYQGYGAGYNYPAYPQATVTATGKRKAAGGMLPYEISAEQAGRMYGYQPTQWPLRGPREDGKVKKARGMWERVLGAVSAVGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAU2</accession>
    <name>G0SAU2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Translin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0047790</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the translin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695144.1">
        <property type="nucleotide sequence ID" value="XM_006695081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAU2"/>
    <dbReference type="STRING" id="759272.G0SAU2"/>
    <dbReference type="GeneID" id="18258817"/>
    <dbReference type="KEGG" id="cthr:CTHT_0047790"/>
    <dbReference type="eggNOG" id="KOG3066">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067225_2_1_1"/>
    <dbReference type="OMA" id="DTCMETC"/>
    <dbReference type="OrthoDB" id="31005at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14820">
        <property type="entry name" value="TRAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="entry name" value="Translin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.200">
        <property type="entry name" value="Translin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016069">
        <property type="entry name" value="Translin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS19322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="34474" checksum="4402AA301E5DFD28" modified="2011-10-19" version="1">MSGVKRDWSGKLKRDGPKPAHPAPARNAFTPMFERLRDELDEHHDRRERIVKLSRDITALSKKIIFSLQRVRKIEPQLPKNIQDEVDARLAEIAKLLAALAPEIQGLNRYRYSRSLMCLEELVEALTFAHYLKTQTLIRYEDLCATVEDLTRQGIAAVATSSEDQVMTDAADGPKQADATKPDPPATVSLTQDDYLYGIFDLTGEMMRFATTTLALTGVLAGSESSTSGDEPRTILQDMHDLGSFFEMLPVGGGSRFQWEKKLEVTRQSVQKVERLGYDWIIRGSEKPKGWVPDLSALDQGPPEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0SB22</accession>
    <name>G0SB22_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0048610</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SRP14 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695224.1">
        <property type="nucleotide sequence ID" value="XM_006695161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SB22"/>
    <dbReference type="STRING" id="759272.G0SB22"/>
    <dbReference type="GeneID" id="18258899"/>
    <dbReference type="KEGG" id="cthr:CTHT_0048610"/>
    <dbReference type="HOGENOM" id="CLU_1366101_0_0_1"/>
    <dbReference type="OrthoDB" id="19209at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.10">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, srp9/1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003210">
        <property type="entry name" value="Signal_recog_particle_SRP14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009018">
        <property type="entry name" value="Signal_recog_particle_SRP9/14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02290">
        <property type="entry name" value="SRP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54762">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, SRP9/14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0733">Signal recognition particle</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS19402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="200" mass="22159" checksum="E4BDB9D22735CE27" modified="2011-10-19" version="1">MSPLSHDEFFTKLADLFTTTKSNLKGSIFLTQKRLSYNPSESQTPSPTSDDPLTAVFPDLTTTLAPAPILIRATNGKSKAARKRGKKVKLSTVVQPDELEAFYGRYAEEPYLGDTPANCFAGGLAGGLGDGLLDQTIWCVPLHLQGLLPFYEVFHLTEQDLHRVHEREQRLHESESTGMQRTWKACVTAAAMFTMLIDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBW0</accession>
    <name>G0SBW0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Clavaminate synthase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0054980</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695831.1">
        <property type="nucleotide sequence ID" value="XM_006695768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBW0"/>
    <dbReference type="STRING" id="759272.G0SBW0"/>
    <dbReference type="GeneID" id="18259536"/>
    <dbReference type="KEGG" id="cthr:CTHT_0054980"/>
    <dbReference type="eggNOG" id="ENOG502QRGK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045411_1_0_1"/>
    <dbReference type="OMA" id="LYIHSRT"/>
    <dbReference type="OrthoDB" id="438224at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000033">
        <property type="entry name" value="Clavaminate synthase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48420">
        <property type="entry name" value="NON-HAEM DIOXYGENASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48420:SF1">
        <property type="entry name" value="NON-HAEM DIOXYGENASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS18886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="42188" checksum="F0C66804B831567D" modified="2011-10-19" version="1">MAPAAKAVTVSLQELKDGTVPFETLCEAFGPESLGILLVKDVPPDFGRLRHHLLSYASYLGNLPKSQLDKLENEKAKYLIGWAKGKEKLRDGQIDDRKGSFYANCAFYVDPSLDCAVPTGQFNPESFPEYLAPNIWPGEDTLPGFRETFEQLCRLIIDVAVLVARSCDRFAEREIEGYPAGYLEKMVSTSTTTKARLLHYYPVDPTGQPSPLSISDAEANDGAPDPDDWCTTHLDHGCLTGLTSAMFVDESKWDPTIAAPEIDSDTQSQRQLPLMPLPELDASPDPAAGLYIKSRTGETVQVRIPRDCIAFQTGEALERITGGRFKAVPHFVRGVRAALSEGRIARNTLAVFTQPNLGEVVDRETGLTFGEFARQVVEKNTVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBY3</accession>
    <name>G0SBY3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0055220</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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        <cofactor evidence="1">
            <name>Mg(2+)</name>
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        </cofactor>
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    <dbReference type="OrthoDB" id="1476984at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <ligand>
            <name>substrate</name>
        </ligand>
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        <source>
            <dbReference type="PIRSR" id="PIRSR605493-1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGS18909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="225" mass="24298" checksum="A9472189CC8C581F" modified="2011-10-19" version="1">MTDQQEDPIIKALQEYTTCDVSDALCKLKVPHGGFLPGLTMWSPQRQDGNTKIIGPAYTVQYAPLDDPRPKHPSHYIDSVPAGAVVFVTTIQQTSNALYGGLMSTRAKALGAVGSVINGRFRDLQEQRELNYPVFARGVGTAPPGPVLKVVGVNIPVEVEADKGPITINPGDYLIGDVNGVVVLPKELAEKALPLMAKQVEADSKMAVEIQKGMTFTEASKRFRL</sequence>
</entry>
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        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
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                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
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            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    <dbReference type="Proteomes" id="UP000008066">
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
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        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
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    </dbReference>
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    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="27"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="188"/>
            <end position="275"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
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        <location>
            <begin position="294"/>
            <end position="370"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
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        <location>
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            <end position="319"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="326"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGS18920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="370" mass="41275" checksum="5937D6FE81212B96" modified="2011-10-19" version="1">MENFETNHPGNDNDNQQQPRDALADGRRIYMGNLLYSVTPGDIEQMLQDTGHGQFDKVHISIDPVSGRNPGYCFIEFCAREGADRALAELPGTLLFGRPVKVGPCHPKTQRQSRWPGSRGSNYQPTFQRWGDWRAGDADAVAAKQLQLQREVEASGQSLLQRDDSVEEQGPSGAIRHIDIRNRVGDGTQLYVGGLGKMIDQEHHDIEMRELFAGFDFVTIGKRITAHESTRHLPGNHNYCFVDFRTPEEAARALNTMNGAPLPGGGYLKLSYPRHKVTKHIALPGVQAQRVDRWGQSSLGEASRGSWEPRNDGYREPPRGRSGYPAHRERAQNGLDGDREQRSEKRREQSERQKAIMAAASWRSGAGATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0SC33</accession>
    <name>G0SC33_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative nicotinamide mononucleotide transmembrane transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0055740</name>
    </gene>
    <organism evidence="10">
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        <name type="synonym">Thermochaetoides thermophila</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Chaetomiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    <dbReference type="OMA" id="LWGICMT"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
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    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF19">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01812)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
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        <location>
            <begin position="51"/>
            <end position="488"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS18959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="517" mass="57819" checksum="A1EED515F5EA4947" modified="2011-10-19" version="1">MSTDSQKKSIDGIQSHEGSIVDLPPDPDAHLSPEEKVEMDRRLVRKLDWILIPWLCVLYLIAFLDRSSIGNAKIAGLSDDIGMSTADYNATLTIFFVSYSVFEPLTNVMLKRMRPSVFIPIIMYERNFRQPIIWLKKADNVSRIAWGASMTGMGFVHNWSGLMAARWFLGVTEAGLFPGVNYYLSCWYKRSELGVRAAVFFSAAALSGSFGGLLAAAIEKMDGLGDIAGWGWIFILEGLLTIVLGVASFWLVHDFPDKAKFLSDDDRARVIRRLKLDQQSSADHESFQMSYFWAAIRDWKMWLGMLIYMGCDMPLYAFSLFLPSIIANLGWNTSVIRSQLMSVPPYAVATVFTVAIGLLADRTRARGLCNICISLFGVAGFAMLLASEDPAVQYAGTFLAALGIYPCIANTISWVANNVEGVYKRGVVLGFVIGWGNLNGVVSSNIYFNKPRYLEGHGVVMAYLFFFLFGGSVLMSMLLRRENAKRRRGERNHWIVGLTDKEIARLGDMRPDFLYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0SC76</accession>
    <name>G0SC76_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0056220</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695947.1">
        <property type="nucleotide sequence ID" value="XM_006695884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SC76"/>
    <dbReference type="STRING" id="759272.G0SC76"/>
    <dbReference type="GeneID" id="18259660"/>
    <dbReference type="KEGG" id="cthr:CTHT_0056220"/>
    <dbReference type="eggNOG" id="ENOG502RY0W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026939_1_0_1"/>
    <dbReference type="OMA" id="LGPKFMW"/>
    <dbReference type="OrthoDB" id="26203at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053247">
        <property type="entry name" value="GPCR_GPR1/git3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42058:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42058">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="47"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="406"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="476"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS19002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="522" mass="57493" checksum="196E6D24DF4BECF7" modified="2011-10-19" version="1">MDCPAPFLSDEYFTNEGFVDGRICSPLGNLTCCLPCPITQWAYPDSFTAMSTAANWVAVAGSVCCIFLLLSWAVLPVDKTFRHYLSICLTTAVLLMNLGFVIPLASKPEECYDAITPHSMSTSSICAVSGFFLIVGGWAGVMWVFLRSLSLHLQICWQLVVGRNFMWFSQALGWGIPAVGVVCALFLSGVSFRYGATCHINHKNSLADLWVPLLVFAGLTIIIQMTTFGYCIKVYLASLADNSASTEGSGMPSYTNSIRTMTPKQAYRRVRRVIALQWRGIAIVLIIIADVIFFSIVFVYQDTTVERVKQNPGVALPWALCLITNKGDKNACLNEASALAVSMPTVGAVLFLLGMNGIWLLFFLGRWSMFTGWRDLIISVPNRNKREFVSVDARLDDVKKDTRSYEMLSRDSGKTMDSSVTPSAVTPLSPTYARSSPVGGPARQNDYVWNNILDNNNNGNSGRRTPDFFGQTARYNAPVRSFSSPRPPQSVRWDPSETFARPYSPPNAGPGGYVNPLGMHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCG3</accession>
    <name>G0SCG3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0057120</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696034.1">
        <property type="nucleotide sequence ID" value="XM_006695971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCG3"/>
    <dbReference type="STRING" id="759272.G0SCG3"/>
    <dbReference type="GeneID" id="18259750"/>
    <dbReference type="KEGG" id="cthr:CTHT_0057120"/>
    <dbReference type="eggNOG" id="KOG0201">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007561_0_0_1"/>
    <dbReference type="OMA" id="FKLWEAQ"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000670">
        <property type="entry name" value="Serine/threonin protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="41"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="437"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="507"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="633"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="760"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1000"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="445"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="508"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="810"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="821"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="847"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="911"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1009"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS19089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1040" mass="112111" checksum="B20631FC3FF49AA5" modified="2011-10-19" version="1">MASLQVRNFSNTKQKALEDANKMQALVEDECAKEGKEPPPYQLQELIGKGNYGRVYKAKDLKHDRVVAVKIINIEEGDTLNPKFADTYSEFMKEFNTLKRLSESGAKNINLTLDVLPVGQTMWMVTEYCAGGSVATLMRPSAPGGLQEKWIIPIVREVAEAIYWVHKEGIIHRDIKCANVLVTEAGGVQLCDFGVAGIIESKLDKRTTFIGTLHWMAPELFDPEPSYSTPVDIWAFGSLVYEIASGLPPNAMQGFNISQLGQHIKHHDVRLEGDQYSDNLKDLVAFCLVEDPAKRPTIEEVQKHPYIYNTEEAYPTSSLSQLVKAYKLWEAQGGTRKSLFAPVGAQGPDDMDSGSANLIDDEWNFSTTLDFDMQVMNADARTVYDVYGSNVDFEFQEPTSRPIKKGRRRLPPQLQPLKQPLEKVFDPNTISNYEENSRAYYGRGPPTVTATAPPKTSDLPLRDNSLHSTLRESLIDLDAGLYEGPGGDYSSNYVDMATIRGAMRLPSDVEDNADGGDVDGDADDYNKPPLSDPVDLDPKRRTQDWKFPTMIPPASANPDVSRFPSHDDDAPRFPGGNRPVLYSHPAAAALGFKHTDPSSFNDASSIPAADNRASVGSLIDLDESLPPAMPDPMTRPGTGYSDGASVAGSDLGGAGPFDLEQRASMYFPPSSGGVREPSIYVSEESDLALGKIITTTQPAVPVDDPPPRFPSLLVDADDAPPRYPSLLIDDPAPRQPSLYVDDVRQPSLLIEDGDIRHPSLLADVPSGPSSVTGGLASGRNTPVMVMRSEPPTAVHSRAPSYDENASDFPGIREESESPHPQELPAPPPGPPGPPAWRKPPGRRGRSHSNASLGSATSGSGPGPMRLQRPPPPRSSSRAAGNYINLQINRPPQPPSQQAPEGAERDYLPSPSLHPSPAPSRGPSPSPSPEPYLPSSSSLDMGHSHLPPAPAFPSDRVLLGAASKEQVREEVMRLLASFAAQLGATKGVVKGLPVRRVVVRRREGPAPSMGNGGSQGGGSQGGQGGAGGRRVRAETPVGAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCH0</accession>
    <name>G0SCH0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cystathionine gamma-synthase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0057200</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696041.1">
        <property type="nucleotide sequence ID" value="XM_006695978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCH0"/>
    <dbReference type="STRING" id="759272.G0SCH0"/>
    <dbReference type="GeneID" id="18259758"/>
    <dbReference type="KEGG" id="cthr:CTHT_0057200"/>
    <dbReference type="eggNOG" id="KOG0053">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011302_3_0_1"/>
    <dbReference type="OMA" id="IMLAYNM"/>
    <dbReference type="OrthoDB" id="10047078at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003962">
        <property type="term" value="F:cystathionine gamma-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051750">
        <property type="entry name" value="Trans-sulfuration_enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699:SF1">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS19096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="612" mass="67006" checksum="639526C7261D409D" modified="2011-10-19" version="1">MPVKQISTPLGHSLPPEAPHNITFHIPGWETARALRRREPELMDQLESIYPRFGPWREVKDLSAVLHAWLKLPDDYEEMLFVHPDVFQTAKRYAGSPRRKEEFRVREEELLFKVVDIPLSALDSNGVGLDGETTGETVRIYLISYPSPRYPGALGVWQNTGTGVSSRLAAALLPAAKAGNVNLIWSGDARDEVRYDYANPSSSSVPIPAPHKGQQILGLALTESHTSLRARIASLAQGKRAQPTPDDVFLYPTGMGAVWRLHQSLSSVRQGGSVVVLGSVFHSSYHLFGDEASGGGMKHIGAVDSEGSGLEELEAYLEGERLAGRRVGYIFAEFPSNPILVSLDLERVRGIADRYDVPVVIDDTIGSFCNVDVLGLADVVVTSVTKSVSGYANVMGGAVTLASCSKYYSAIKETLSARFLNEYFAADAAKLLSNSQDYFPRSAILNRNALTLATYLHSKITPTSPLKAIHYPPFTNTASNFRHVMRPSPSSPSVTPTSQNEFTPGYGCLLALEFRTLSQARQFYDHLSVYHGPHLGAHLTLAFPFNDAIWGADPEAARYVASFGARPEQVRVSVGLEDEQELIDTFEEALRWAEGVEVSEANGMNGVRESLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCK8</accession>
    <name>G0SCK8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0057590</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696079.1">
        <property type="nucleotide sequence ID" value="XM_006696016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCK8"/>
    <dbReference type="GeneID" id="18259797"/>
    <dbReference type="KEGG" id="cthr:CTHT_0057590"/>
    <dbReference type="HOGENOM" id="CLU_1224631_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="226" mass="24086" checksum="B054A5CADDF5E924" modified="2011-10-19" version="1">MHAPADTSPSTSRHSRNGMNASLHSTVETGMHTAERSPQLNEGNMSSSQLANASSRSDGDSHALSLSGSDMTEIEIELHKDCLMQGITSTDKRDVIISMISLQGSVHAYTTFHDWVSIPSAEALVLEQEMPSSPTAMAVQKPPESGCYRMSSPSSSQSGSSCSLSSWSLDRTMMTPSTLTNFDADSAISGRSSMTLGLDWAVLQIEIPLVSSIDDLNGIGAWAETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCP2</accession>
    <name>G0SCP2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell wall proline rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0057930</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696113.1">
        <property type="nucleotide sequence ID" value="XM_006696050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCP2"/>
    <dbReference type="STRING" id="759272.G0SCP2"/>
    <dbReference type="GeneID" id="18259831"/>
    <dbReference type="KEGG" id="cthr:CTHT_0057930"/>
    <dbReference type="eggNOG" id="ENOG502RD9J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007264_0_0_1"/>
    <dbReference type="OMA" id="FNTPDMR"/>
    <dbReference type="OrthoDB" id="5406427at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="821"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="822"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="867"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="901"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="919"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="929" mass="100051" checksum="EDF41B10805B943C" modified="2011-10-19" version="1">MMIEPPSPVHEHDATLRLPAEAASQVPRSLPQVVPRSNPPPPNPPFVFPPRPLSSSSTTFPRTTARRPRSAIEPRDAFPRVEVDNGKPASRPPPLPAFSFNPGASLPDPPSADKMFLSPPESPSAQSSPRLIPTRPHGLGHRRGGSEFVGGSIRDGEAITVLTNGSSPTKSESGTASPMLQPTRPRRGHAHRRSAAISSHDLSSIIVPPSNRNVQGGSSPSSPVVPKGQSGLSMSPEAKPVEAAPTVSVPETEASSSIQKEEFALAPEPETQPAKPATRNRVGFSDTLEYIPRPVSIVSTDTSSTVTARPGHSVSGSISSIMEVNHTSGPNYPSVTESRPSTAGAILERSQTSQEQDVPPPARRRGSIPLLGSIPPAFPSGPATPSPTRASKKWSLFGRDSATGSPTRSKIESPRISDLNLDAEERKSLERAPNGEADEPNESQASSKAADKKKKTKKPKKVKNWAGSILSRKGKHHGKPKRRAPTPPPLRPAEFEDIADMFPEPEAPSPTCPPSQATEGVSWETWTFPKPSTTSDDDSSYPMIDLDAALGPFNTPLPRNPEWEAAQRAAGGRYRKALHSAAGMSRFSGPGMHYYHRRAESAPELAPWEDRFGFPRFGSSSTMADVFEEDEEEEEEDSKANSVKQPTTAPETTTKSELLTPTQEDTAAEQVHHDGMPSSSTASLPTDAPAKSREPSFEQPRILSSEDVIMVEPGHFYSATPSTPSLAHDKSASATPSPRHVFRPKDLGPVEVSPLDLPTPSLGPVSPWSTSQSPFPSPRSPMSYDAQCISTAPSSITDGDFQSLLLGEPGPEVRISVDDIPSLTSSQSTMTRDSLFPQHPQARHPPLKDQPRPASFTATAFGRRRSSLASLSRLVSSSHGERSKLSLEVTLDSEPEENNKKKSKISKAKRLSRMMQFWRSKESHHHKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCU0</accession>
    <name>G0SCU0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol-3-phosphate 5-kinase</fullName>
            <ecNumber evidence="2">2.7.1.150</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Type III PIP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CTHT_0058410</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57923"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.150"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.1.150" evidence="2"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696161.1">
        <property type="nucleotide sequence ID" value="XM_006696098.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0SCU0"/>
    <dbReference type="GeneID" id="18259879"/>
    <dbReference type="KEGG" id="cthr:CTHT_0058410"/>
    <dbReference type="eggNOG" id="KOG0230">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000480_0_1_1"/>
    <dbReference type="OMA" id="QSVWNDT"/>
    <dbReference type="OrthoDB" id="158357at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000285">
        <property type="term" value="F:1-phosphatidylinositol-3-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03334">
        <property type="entry name" value="Fab1_TCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17300">
        <property type="entry name" value="PIPKc_PIKfyve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.810.10:FF:000001">
        <property type="entry name" value="1-phosphatidylinositol 3-phosphate 5-kinase FAB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000007">
        <property type="entry name" value="1-phosphatidylinositol 3-phosphate 5-kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000283">
        <property type="entry name" value="1-phosphatidylinositol-3-phosphate 5-kinase (Fab1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.800.10:FF:000005">
        <property type="entry name" value="1-phosphatidylinositol-3-phosphate 5-kinase (Fab1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044769">
        <property type="entry name" value="PIKfyve_PIPKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748:SF7">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="15">
        <location>
            <begin position="424"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="PIPK" evidence="16">
        <location>
            <begin position="2192"/>
            <end position="2523"/>
        </location>
    </feature>
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            <begin position="1"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="14">
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    <feature type="region of interest" description="Disordered" evidence="14">
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        <location>
            <begin position="2013"/>
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        <source>
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        </source>
    </evidence>
    <sequence length="2523" mass="279806" checksum="A0CA7E29568FAAF5" modified="2011-10-19" version="1">MVDSNGSRQPSLAASLPPSPVDARPRRDSIVSLPVSPPIDREQLALALDKIHTSASQSDALTTFNDFAPPPGSLPVPEPKSTATEIVQQGLSGLYSRLKEAVGAVSKSASSHEAVGDGDNYEAGTRSTTSPSAGTSKAPFLPRGEGSGSSSSALEPVRLSSDTHTSGAMSASSQTHLQSSSKASSIATTTSVAAKLSSPALQGLSKLSKAVLSVTANPAVAPVTVQGQVLLDKEAARGITTHVDDVSVRPAGRRSISKPTATVQSPILSANGSLDSISTIDRIMIPARTTRDEALSTDGGADTPRSPVQSSVPERRASAAFRLAPLDVLRRPAVIDRLAFPKGSSRSRSSSMEPGTTEASPISTSAHSSLYHESFTQNERPQILQSGIIRIPGTTTNEGASDAVSARLERMRKQVLSKEFWMADETCKECFRCGAAFTAFRRKHHCRTCGCIFDSKCTSQISGQKFGVQGSLRVCKTCLDVINRRYDSASDDSADESYLPAIFRTSQAKHTPTSVKQRTEDEGSTSERTEQTDQADDGKVAVTPMMAIPATRRVGDSNRNSAVLEIDLPQLSRPSSSRSLKSLAAGRPQSSGHRRHHSKHNFLTRLKGTMDDRAPFRAASGDEVVKKANTNAFHDDNIIDPDLAEFMSDDSSDDEQVSDIYSVMKTDEFQPGSVDPDRASFGNFMGSGRKHRFRQGDKSMSIGGLSHINRGYEEGGGLQSLTIHHGRPLRRRNLSIASASIHHLRSPRPKSAIAKGPTASADALSVFDAMVGDIPGLKRTESTRNGQSTEGGLNPASWQHVKKLFRQLLDDDKIPNPESWEKALLPIIDQCADDVDPDIRSGDVMDIRHWVKFKKIPGGKPSDTAYVHGVVFTKNLALKSMPRRIRNPRIVIITFPLEYQRHPEQHFMSLQPVIEQEKEYLRMVVNRILNLEPNVLLVEKGVAGVALQYLAEANVAVAYNVKPSVIEAVARIVNMPVISSMDMLSLGARVGTCENFEVKTFVNNDIRGRKKTYIFISGCPKDRGCTIALRGASTEILARMKRITEFMVYVVYNLKLETCLMRDEFVQIPTELDSLMSADSSSTQTSHGLLPVVGPAPNSSISSSAFTAQQSSTEPSDRSPTNMNAGNLSSSDSTGANSELSTSEITAETILRPAVQQPAVEEVNTITSAQDSQSPLQVPEDIPMPAFYSDMVAKYETRILSVSPFVRFTQPYLLMKAREQERRLEYLKRLRDQDQIQEPDQPDKPEEFQLIKPEMIHQMGQKAPRKIMEVIHAVHDAEYDKALHNYLTQTKQWETYLQNCLDLFDPYAHQNIVVLSSVTCTATQIPCVEPALMAIEFYNQHPDEGGFLDQDFTLGQYIEDICDTANYVCTANNCGRKMYEHHRTFVHDNARLTIILKPSPQWPENFPEKPQERGGGDDEGTGICMWNYCKVCDKHFGLMPMSVSTWKYSFGKYLELSFWNTGLRLHPETGCPHDHKKDHVRYFYYTYLDIAVKVHYDPIDLYEIIVPRKRITWKVDIDLKLKNDVFTKAEERWNRFINSVKARLKSIKIDSVLPEKAEDCKAEVDRLLEKAEEDHKEMIKVLQNAYMNSKYYEIIPFNVVFRQMLERATEWDSAFTQFESKFLSDKDVRQLTLIQLKKMFSDHEKDPTSTDGTTVGSESEEKMTPVTSPNESSDVGEKLSPSSEESSVPQLPEKTTQQEQLSQPSELGDSQSHEELLSPSLATQPITNQKEEDSVKAEEQPDAVKAGEAEAQIPSAPRMPTSTSVSEVGAKGVKPPSNQPAGSSSSAGVANSPTLSRKSTIASHSSPTEPSSAAKTSHKEPSLSEKVEQIRRQNRAHAITSSGSGAEAPTETTSPFSPDRTMLPRRTGTNVSPPMLRTFGQQSGTVSGPLPRTQSTIGKLLRDQKVAQEAAASTDAQKGQTGDDTLKGDKKFLGTLKPHRKAGPSNIPRFVHNKRDSKVSKLAYHFEQLSREFEKERLKDRKQRATKLHHTRAFLPRSSTKTIVEVYRDVDQAVQEPGPSDEDHLGRESSEKQSVETSTPDITPAETQNKPPETEPSSPASPPSQERRDKVFATTEGETEENKVQEENRVSTDDEAGSDVEGTGLSFDDILPDVNEIAESLEQNAIPEELPKHQKKSLMDRLANFWAERSASSWPQLEYPVNMGDHVMFDSDVIVREDEPSSLVAYAMSLNDYKEKLAAIRRDLRMSNFGETDVSGDSLEDNMGTPVDPEAAKERARKIDMELEKTLLRSTGTHVKYQFVHGTAKMMCKIFFAEQFDALRRKCGAADRFVESLSRCLKWDSKGGKTKSVFLKTLDDRFVLKSLSVPETQSFLKFAPDYFNIMAEALFHELPSVIAKMLGFFRVHIKNPVTNTDIKLDLLVMENLFYDRTPSRTFDLKGSMRNRRIQSTGERDEVLLDENMVEYIYESPLFAREHSKRLLRASVFNDTLFLAKQDVMDYSLMVAVDEAKKELVVGIIDCIRTYTWDKQLESWIKQRGLAGGSRNRPTVTSPKEYKSRFRVAMAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDH7</accession>
    <name>G0SDH7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AMP-activated protein kinase glycogen-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0051820</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695523.1">
        <property type="nucleotide sequence ID" value="XM_006695460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDH7"/>
    <dbReference type="STRING" id="759272.G0SDH7"/>
    <dbReference type="GeneID" id="18259220"/>
    <dbReference type="KEGG" id="cthr:CTHT_0051820"/>
    <dbReference type="eggNOG" id="ENOG502QVY6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063252_1_0_1"/>
    <dbReference type="OMA" id="WDNYAGQ"/>
    <dbReference type="OrthoDB" id="5364946at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40625:SF2">
        <property type="entry name" value="GTP-BINDING PROTEIN ESDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40625">
        <property type="entry name" value="GTP-BINDING PROTEIN ESDC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="31910" checksum="58D0813E6BD60B4B" modified="2011-10-19" version="1">MSAIQLSFSLRVSSGVKTVHLLGSWDNYTNQLPLSKDKSSSKGTWKGTFRFQPSVLQPGQRYWYYYIIDGYHVAHNPSEDSTIEPTTGRALNILDVPESSKSSSRTSRESTASYSTSDPGDEEIAKGRPLSISQIKAPQPVNPKAARHILDADFDEEELSAHFAAAALTDDDCYYLDESDEDAVYPGFDTPRSRASSVSSSLSYRSDSSAGHSSGYSTPASECSSCICERYGITRRGERVRLDCGGSRCSYDDSCSSCSDSEPEYVERSSRRHGIVVRHCVMRRVLLEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDI8</accession>
    <name>G0SDI8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="5 17">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CTHT_0051940</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 17">
            <text>2 5-aminolevulinate = porphobilinogen + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 17">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the ALAD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="5 17"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695534.1">
        <property type="nucleotide sequence ID" value="XM_006695471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDI8"/>
    <dbReference type="STRING" id="759272.G0SDI8"/>
    <dbReference type="GeneID" id="18259232"/>
    <dbReference type="KEGG" id="cthr:CTHT_0051940"/>
    <dbReference type="eggNOG" id="KOG2794">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035731_0_1_1"/>
    <dbReference type="OMA" id="YQMDYAN"/>
    <dbReference type="OrthoDB" id="1530at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04824">
        <property type="entry name" value="eu_ALAD_PBGS_cysteine_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000048">
        <property type="entry name" value="Delta-aminolevulinic acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006762">
        <property type="entry name" value="PRK09283.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458:SF0">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="10 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 17" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="14">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="14">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGS18589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="382" mass="41681" checksum="CBD780F9AAC2F17E" modified="2011-10-19" version="1">MSFSSLVQDLSLRDSNGLRRRGDASVSTVDDRASHISLAKSYTSTAATSVSISGDISSQLHAGYCHPLARTWQAERQLTKSMLIYPLFISDQDDEETLIPSLPNQYRRGINRLVPFLEPLVRKGLRSVILFGVPLKPGTKDALGTAADDPEGPVIRSIRLLRQRFPQLYIIADVCLCEYTSHGHCGILRDDGSLNNQLSVDRISDVAVAYAKAGAHCVAPSDMNDGRIRAIKLKLIEEGIVHSVTLMSYAAKFSGCLYGPFRDAAGSAPSFGDRRCYQLPPGGRGLARRAIMRDIHEGADIIMVKPAGQYLDIISDAKELGRDLPIAAYQVSGEFAMIHAAAKAGVFDLKGMVFESHESILRAGATIIISYFTPELLDWLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDN7</accession>
    <name>G0SDN7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0052430</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the free Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695583.1">
        <property type="nucleotide sequence ID" value="XM_006695520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDN7"/>
    <dbReference type="STRING" id="759272.G0SDN7"/>
    <dbReference type="GeneID" id="18259281"/>
    <dbReference type="KEGG" id="cthr:CTHT_0052430"/>
    <dbReference type="eggNOG" id="ENOG502RXXR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077738_1_1_1"/>
    <dbReference type="OMA" id="FQGPIAC"/>
    <dbReference type="OrthoDB" id="15735at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033745">
        <property type="term" value="F:L-methionine-(R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000048">
        <property type="entry name" value="Free methionine-R-sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000614">
        <property type="entry name" value="FRMsr_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051330">
        <property type="entry name" value="Phosphatase_reg/MetRdx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021:SF15">
        <property type="entry name" value="FREE METHIONINE-R-SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021">
        <property type="entry name" value="GAF/PUTATIVE CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01320">
        <property type="entry name" value="UPF0067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="89"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS18638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="191" mass="20742" checksum="D045863938C149B3" modified="2011-10-19" version="1">MRIQLQPKMVHADASNFADGLTKEQAYQQVLDQAEGLFYGQRNWVCNLSNAASLLWHAYKALPSPSNRVNWAGFYTLDPLSSPTSPSLILAPFQGKVACQTIPFGRGVCGAAAATAQTQLVTDVDAFPGHIACDSESKSEIVVPIVVGGEKRRVVGVIDVDCAEKNGFDETDRVWLEKLAELIANGCDWPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDT0</accession>
    <name>G0SDT0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0052880</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695626.1">
        <property type="nucleotide sequence ID" value="XM_006695563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDT0"/>
    <dbReference type="STRING" id="759272.G0SDT0"/>
    <dbReference type="GeneID" id="18259326"/>
    <dbReference type="KEGG" id="cthr:CTHT_0052880"/>
    <dbReference type="eggNOG" id="ENOG502R9DY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041437_0_0_1"/>
    <dbReference type="OMA" id="LFGFREC"/>
    <dbReference type="OrthoDB" id="1022638at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF2">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="16"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="312" mass="35885" checksum="0EA82CF5109E1E1F" modified="2011-10-19" version="1">MRWSTNKAVVGSFEGCEIVKVLVGEEQREFVLHRQLLCDTSEFFRTNVEGIPSPSSPTETDDDEEVLWLPNESPDMFELFVLWLYQRRRFAWFLDNSLRGLTPDECRAVRTNLVRLHLFAAVIDLPVLQDAAMDALQDMYLRFDWDMSPRFLAFLYGECDAQHAVRLRKWAVAMFAWTLHAGDKAVTMANQVEKLFAAYPALKADYYMHLDKMAKSRADVRIKNPQLRLPVNKLHSGERFFGFRQCTFHSHRATVGEGTCPHALAAQQLPWSLSALPKREKKDDVESDPEPELILSPVKDLNEIFFPTLSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDZ0</accession>
    <name>G0SDZ0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Elongin-A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0053500</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695686.1">
        <property type="nucleotide sequence ID" value="XM_006695623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDZ0"/>
    <dbReference type="STRING" id="759272.G0SDZ0"/>
    <dbReference type="GeneID" id="18259388"/>
    <dbReference type="KEGG" id="cthr:CTHT_0053500"/>
    <dbReference type="eggNOG" id="ENOG502SF7P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_613939_0_0_1"/>
    <dbReference type="OMA" id="NGAITIC"/>
    <dbReference type="OrthoDB" id="21513at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070449">
        <property type="term" value="C:elongin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051870">
        <property type="entry name" value="Elongin-A_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010684">
        <property type="entry name" value="RNA_pol_II_trans_fac_SIII_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15141">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15141:SF76">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06881">
        <property type="entry name" value="Elongin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="446" mass="48493" checksum="1230B642C238B640" modified="2011-10-19" version="1">MDIKGGPRSLLEMALSVAIDNIHLIDDMGDLPEQYSQQLLRHVKSAARLREIELNSPHLDTTEHWQRLIRQDFRLLQEKHKFVPKNPKSWHKVYIKYKGIQDEQIQNATKRLEEQLAAHHKQEQKSTTPIISGEEALRMASRRRRSFDKDGEKKKKSVLEEIRKAAKKEARIFRVKRPDIPPTRLNSAPISMINQQIRKTYYAEPPVSADSSKPQKIIAPRTLSGKPNSRMSQKPQANNGAITICIFSDDEDDEAGKAGGGSLFSDDGDDEDDLFGDKFVNSHSLSKPTSLPAKEGASRSGTSSAAAPAAIIPSCPPASSLQNGRPKKSAGATAAKYQPTGLLAAKFRRKRPSASSGAGACGSTVVRKTVAASPPAAIPSAQRPSTSSAAGDGSSLRPSQSTSVFPSPPPPSPASAVPSPNGQPTLKHHQDNAVMLKPPSKRPRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0SE22</accession>
    <name>G0SE22_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Telomeric single stranded DNA binding POT1/Cdc13 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0062140</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EGS18199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006696467.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="cthr:CTHT_0062140"/>
    <dbReference type="eggNOG" id="ENOG502QPW5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002756_0_0_1"/>
    <dbReference type="OMA" id="RARMSYG"/>
    <dbReference type="OrthoDB" id="5363079at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011564">
        <property type="entry name" value="Telomer_end-bd_POT1/Cdc13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF12">
        <property type="entry name" value="AT HOOK TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1578"/>
            <end position="1715"/>
        </location>
    </feature>
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        <location>
            <begin position="217"/>
            <end position="368"/>
        </location>
    </feature>
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        </location>
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        <location>
            <begin position="1235"/>
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        </location>
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        <location>
            <begin position="344"/>
            <end position="355"/>
        </location>
    </feature>
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        <location>
            <begin position="605"/>
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        </location>
    </feature>
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        <location>
            <begin position="641"/>
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        </location>
    </feature>
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        <location>
            <begin position="661"/>
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        </location>
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        </location>
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        <location>
            <begin position="794"/>
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            <begin position="850"/>
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            <begin position="955"/>
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        </location>
    </feature>
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        <location>
            <begin position="978"/>
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        </location>
    </feature>
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        <location>
            <begin position="1018"/>
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        <location>
            <begin position="1123"/>
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    </feature>
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            <begin position="1209"/>
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            <begin position="1416"/>
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        <location>
            <begin position="1450"/>
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            <begin position="1464"/>
            <end position="1482"/>
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        <location>
            <begin position="1533"/>
            <end position="1548"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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            <dbReference type="SMART" id="SM00976"/>
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    </evidence>
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            <dbReference type="EMBL" id="EGS18199.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
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    </evidence>
    <sequence length="1731" mass="187762" checksum="F2ECBD9668ABB626" modified="2011-10-19" version="1">MASTDGDDPIAAQLASRSLTPIAQLNPDLPDQSTRAVRGQVTLTWPFNSVTKTVAFLLSEPDVRLRRNKGQVRVEFSGPCARAVAELGVGAFDEVVIGLEGTEWDEDRSLKRPLESRVGWQVGFRRRVVLQVTFGESGEKRCLNIDHSEEEGTPEPQPTNEIQKAATPEADPVTFVHSAVRQITDLPANEYPSPAFLKRARLSYGALFEGDFDIFEEDGGIKGRGRKRTKFSRESTSWRYASQSPSPEPEPASPVDEVMTDEESETRAAQTPSRPLMMDEGCQTVDVEETSGVAKVGHVEEAPSPTPLPKETAVSEAMEKTPGPKPAPTAASGQVTQPAGSPTREPESPQKEREGVSTPQQKSDLQIRIGEPHKQNSAQQHDLPSAKSLGGFSDSLFGTPKSSTFGSSNLGTSIYGTSAAQVAPSVNLADQVRFGFSHVPHEAPASASHEAVATTGRGHEATTTTSYAHEAAYPVSYLDQAAPTDAIHPPFTTSDTQPPVPAHDQPIPPVIEQFAHGHWEMATQAPQYNPTEGGHFGPGALVEGSHVDIGHPSLHSSAISPHDVPAGFASYGPGLPAATAEESSKHETPVPEGGSNKTPIVLSDSSDEDDDKQEEVEEEEDEEEDAAVDDEKDAEAEEDEIAYREKLEEGDYDQRMYSVPSDDDEGLSEEEEEAELEEEGRYGNPEMYDEDGERWEDDEEEGEGDEWGEEDEEVEDDEDDEEENKKEDPDYEEEEEEEEEEEEEEEDKEDYDRYMRRYQPRKPPAPQKPKDPVVISLLSDSEDEEPAPTPAPAAKPSTTTTQQAPSATQPKSEPAAVSSSPAAAEAAEKPSKETAAITARQKSPTPVELSQKDIKFVEDEKGRLTSSLYGGTQVIDFAPHPGDGRSTGSRAEIEEDISSREESPDKVVESVEGRVYQSVEREDEEDRDVEIVGSEPSTSESSDEGLFVKQPSYQASISSEGESAEDGSAVGSKRTDDGQESELLEEEEEEEEEEEEEGGSEEESSDEGSGEESKEIIEIEDEESEESASEGVESVDGEVEEVEDEEEGEVQVLDKKRAKDEGGKVESVAAESKVHEIVETQDEHSEPEAAENNAVEDATVKRSEDEAIKSPETEAPKRESITEDSTQSQPAFSTQPDLPQSPSDKEEDEIMAEAASASSPDIQPMPMETEPLKPHEDEDEDMGDADAWSDTQEKMDEDAQSFHSASEMEVVHESHTGAEDVDMVDAVSQEGEETIVGGNAEERMEDAPEVGVQPASGENVEMTTETQTQTLTQPMAEVTAEEMKAQAMEGSDGFPPPEQSQVVREKMQEVHQGQQEGELVPEQLEPSVVESKPEDSARVETQTDKQHPESGATGEVESAPTQQAEDHITQAKAREDPQKAEETADESTQSQEAGPAPGSSAQAPITLDEDAHAEASDEAASVDEADHGDDETQEFEEPEEDEATQLHPEYDEDELDDEIAIFEQLTQEAQRSFESYSTASESQPREKSPSPDLSIDLARQAVAARSSEAHSSSPTAAGDATRPTAPLGASKGPPSRVALARAALASPSKHGRETADGSNPGSLKTEITKHLQTHHPDFAPLKSLRSHASQALSLLAVVTTPPLAPPTRAKGGPREYFLAFWVTDPSVAPNNVVEVQIYRAHKDSLPVVKTGDVVLLRGFVVTGLRGRGWGVRSAGEGGGLFGMRPRLAPSTGIMIMEQKGRGRQKRLRSARHRSEDLPSKTGRAVLKLWGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G0SE24</accession>
    <name>G0SE24_CHATD</name>
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        <submittedName>
            <fullName evidence="2">DNA repair protein rad7-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0062160</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006696469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SE24"/>
    <dbReference type="STRING" id="759272.G0SE24"/>
    <dbReference type="GeneID" id="18260254"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_006598_1_0_1"/>
    <dbReference type="OrthoDB" id="1924287at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNI-like"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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            <begin position="1"/>
            <end position="25"/>
        </location>
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            <begin position="31"/>
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    </feature>
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        <source>
            <dbReference type="EMBL" id="EGS18201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="435" mass="47855" checksum="CE63D4195B686084" modified="2011-10-19" version="1">MANHHPTQSQPSAQPDTPSQLQPASPAQLGQPGQQRTTRGPRSLVTMALTIAVAHLSRVPTLKGLPDFLISQLARLVVQRGHPLTLATLQHFLPYLGQRHTLALPIRLEELDLEGAGNLSARAWIRFLEGRGGHFLRKLRVGPGCGGLNNEVLLVLAEKCPGLERLKIVSSGGGGAITDVGIAALAGLTRLKRLSLCMGQMVRVSVDVVIGVIRAVGAQLETLVLEEFFNANDAVLEAIHETCRCLRKLKITGAPCLTDGGLAKLFRDWENPGLEYVEFSGRKDQWVSGRFYGGRLEGLWLDGFYALMAHSRTTLVQLKVGYSRKLLDWVMPDVFDKKRNEWPALRKLDLRGVWAATDAVVKAAFKSCPNLEEVIVYDCEDVYKVRPPPGKTIVGLVTRRGSYWGRHPKNSGVGWVAAEPRKTKEFYILSVGNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0SE34</accession>
    <name>G0SE34_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative exosome 3'-&gt;5 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0062260</name>
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    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006696479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SE34"/>
    <dbReference type="STRING" id="759272.G0SE34"/>
    <dbReference type="GeneID" id="18260264"/>
    <dbReference type="KEGG" id="cthr:CTHT_0062260"/>
    <dbReference type="eggNOG" id="ENOG502S1Y5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055310_0_0_1"/>
    <dbReference type="OMA" id="SNTGCPR"/>
    <dbReference type="OrthoDB" id="5560525at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070319">
        <property type="term" value="C:Golgi to plasma membrane transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040351">
        <property type="entry name" value="RAB3IL/RAB3IP/Sec2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009449">
        <property type="entry name" value="Sec2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430:SF4">
        <property type="entry name" value="GDP_GTP EXCHANGE FACTOR SEC2 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430">
        <property type="entry name" value="RABIN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06428">
        <property type="entry name" value="Sec2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144284">
        <property type="entry name" value="Sec2 N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDP/GTP exchange factor Sec2 N-terminal" evidence="4">
        <location>
            <begin position="228"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="100"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="184"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="316"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="48"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="316"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS18211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="360" mass="39293" checksum="1301C9EA0D8E9D6C" modified="2011-10-19" version="1">MSATATATATTATPVTMASGTLTTAPPQSQSQSFCCPRCGFSLTLPPFEETQAALLTAQKQIADLEAQVRLLNQKATAAVDRWADYEDELARLRAQLDARPQTPRQQQPQHNGVPSPSAQSTVGALGDSSDKLGFPGHRQQTSLPTPPSSAAGLPSPSPSRTSFLTSGAAARISALLSSRRSAPALKPLPSQPQQQQQQSQSRPPSQPTPGSLLPPPTPTPSVTPSEQTDTSTLLSMLSQEKSLRQQAETQLRAASREVEELSASLFEQANEMVATERRARAALEARVAELERREEEKAARLAVLERAVGRIERVRGVLEEGGRERERERERERERERERERERERESRRSIRGSLQGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0SE35</accession>
    <name>G0SE35_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="3">5.4.99.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0062270</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="3"/>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696543.1">
        <property type="nucleotide sequence ID" value="XM_006696480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SE35"/>
    <dbReference type="STRING" id="759272.G0SE35"/>
    <dbReference type="GeneID" id="18260265"/>
    <dbReference type="KEGG" id="cthr:CTHT_0062270"/>
    <dbReference type="eggNOG" id="KOG2529">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032087_4_1_1"/>
    <dbReference type="OMA" id="FAINKPC"/>
    <dbReference type="OrthoDB" id="9995526at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160148">
        <property type="term" value="F:tRNA pseudouridine(55) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02867">
        <property type="entry name" value="PseudoU_synth_TruB_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000014">
        <property type="entry name" value="PUS4p Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767:SF2">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE TRUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="TRNA-PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase II N-terminal" evidence="7">
        <location>
            <begin position="65"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA pseudouridylate synthase B C-terminal" evidence="8">
        <location>
            <begin position="336"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="229"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="398"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="409"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="425"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS18212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="454" mass="49820" checksum="6BFA084F2DD7D730" modified="2011-10-19" version="1">MATDKVLEGVFAINKPLGMSSAQVIRDCQLYFNPSKLFAPLLEQERAQRAKESNYQKNRRRKCKQEIRVKMGHGGTLDPLATGVLILGAGKGTKALNNFLACTKTYETIVLFGASTDTYDRTGRIIKKGDYSGVTREAVEKALESFRGRIKQVPPLYSALKMEGKPLYEYAREGKPIPREIETRVVEVSELELVEWYEPGTHPHRWPTEEAGQDEKNLVNSVWDVAKKQQQNAASGAQVILDQRDGKKHDAPVTVDRLESLEEHSSSSKRQKTNEGTAAPAATTATTREPRLVPPQGKGSNLVPPPPSPDTPPPWEGKGPPAAKIRMTVSSGFYVRSLCHDLGEKLGCGAMMAELARTRQGQFVLGGENCMEYEDLLKGEEVWGPKVKHMLELWNGTATSTQTAASDGQKQENNGKKSRESSPAGKRKSSPKRKSREGSPAKQAQTEPVAAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G0SE71</accession>
    <name>G0SE71_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0062700</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696579.1">
        <property type="nucleotide sequence ID" value="XM_006696516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SE71"/>
    <dbReference type="GeneID" id="18260308"/>
    <dbReference type="KEGG" id="cthr:CTHT_0062700"/>
    <dbReference type="eggNOG" id="ENOG502T75R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164903_0_0_1"/>
    <dbReference type="OMA" id="PYERIPT"/>
    <dbReference type="OrthoDB" id="4829316at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="97" mass="10728" checksum="0A56A14A75CC2133" modified="2011-10-19" version="1">MIARAATRATAAALPANATRQALIRRQNVSLMRSLRDFARGFEPHPFQRLPVASNPAPADYGRLVKRVSQQLVVYPLVAFGLLGWPYVAYKLVDGHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEB1</accession>
    <name>G0SEB1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial outer membrane protein porin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0063120</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Forms a channel through the cell membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic mitochondrial porin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696619.1">
        <property type="nucleotide sequence ID" value="XM_006696556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEB1"/>
    <dbReference type="STRING" id="759272.G0SEB1"/>
    <dbReference type="GeneID" id="18260350"/>
    <dbReference type="KEGG" id="cthr:CTHT_0063120"/>
    <dbReference type="eggNOG" id="KOG3126">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044399_0_0_1"/>
    <dbReference type="OMA" id="FKQPAFH"/>
    <dbReference type="OrthoDB" id="7827681at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008308">
        <property type="term" value="F:voltage-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07306">
        <property type="entry name" value="Porin3_VDAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.10:FF:000004">
        <property type="entry name" value="Por1 mitochondrial outer membrane porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001925">
        <property type="entry name" value="Porin_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743:SF70">
        <property type="entry name" value="GH26960P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00185">
        <property type="entry name" value="EUKARYTPORIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00558">
        <property type="entry name" value="EUKARYOTIC_PORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8" id="KW-0626">Porin</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS18288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="283" mass="29984" checksum="22DA0BC031B27306" modified="2011-10-19" version="1">MSVPAFSDIAKAANDLLNKDFYHLSAGTIEVKSNTPNNVAFKVTGKSSHDNATSGAIEGKYTDKANGLTLTQTWNTANTLETKIEMADNLAKGLKAEGIFTFLPSSQSRGAKFNLHFKQSNFHGRAFFDLLKGPTASLDAVVGHEGFLAGASAGYNVQQAKITGYAAAIGYQAPTYSAAITATDNLSVFSASYYHKVNSQVEAGSKATWNSKSGNAVGLEVAAKYRLDPVSFVKAKINDRGVAAVAYNVLLREGVTLGVGASFDTQKLDQATHKVGTSFTFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0SET6</accession>
    <name>G0SET6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0059650</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS17952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696283.1">
        <property type="nucleotide sequence ID" value="XM_006696220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SET6"/>
    <dbReference type="STRING" id="759272.G0SET6"/>
    <dbReference type="GeneID" id="18260003"/>
    <dbReference type="KEGG" id="cthr:CTHT_0059650"/>
    <dbReference type="eggNOG" id="ENOG502S7T4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015973_0_0_1"/>
    <dbReference type="OMA" id="EQDMAFT"/>
    <dbReference type="OrthoDB" id="5344169at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11392">
        <property type="entry name" value="bHLH_ScPHO4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="3">
        <location>
            <begin position="664"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="319"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="379"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="501"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="700"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="752"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="123"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="379"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="552"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="707"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="752"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS17952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="823" mass="87482" checksum="EC5EFA85CA7F8731" modified="2011-10-19" version="1">MDPSTSWAVGDRHGATVTDDALQQFLNNMNMDAAMGNLADGMNYDFQDFPTTVATAPMLSAHAPEPLDLTMSGTDAAQAAAAAAAMLVSPAMGPVQSIATTAPPFGSIPASMMPPPTPSGAVVDSIDAQIQFLQQEKLRHQQRQLEQQQQAAALFARQQADIIPPTPQSFEMQPGASQFLGQSNATEQHHHHHQQQRQSVSFQSLTDQSDVRRPLDNVHHYHHRGSEHLTDRLQVSFTPLVSPAVTPLDANFSIESQFNVTGTMCFSPLTSPALHAQNDCLNVFDQRQTMNDSPIEMDLDSTVAAAQNQPPGDLAKKMRKNAAKARAKSGAAGIKQSPISKHVRRKTATTPSLSAQALSEIAEGVENSNIQDNQQLLLPTPMMPTASSSSSTASVGGITDSENGSTSPEAMPDSVTSEMPPPPLPRSRSAKPSPFLAPQGGAGGVLGSLQPRQGVASPATPASLMKLNSPGTRSSGVKAGSHGAVDNDHIEAFSLPESASFGHSTIVPAPSTSQPVESTSTQPTPKQPPKDSGPFSKTPALVPLPSPSLRIPPTAVSSAAPSPQIPAMNSGLDSRKTTPQIVPRNSKKRPSVSSIPAGATISPALRPKISPNIKPLIPGGGQDVIDEEEASRILASKSNYQRILEGNHLPGVSYPSELSANLTQKRTSHKLAEQGRRNRINSALQEIASLLPKKTFLQQQLKESSEGEGGGNNSSEGGQGQGQQRKNSGGVPISKASTVEMAIEYIKQLQREVAEATKRAEEAERRLREREERERAGCKESKESGKGETNNKDGDVKTDEDSKEQSQKEDRGKDLDATMTESC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G0SF27</accession>
    <name>G0SF27_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">threonine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CTHT_0060580</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696374.1">
        <property type="nucleotide sequence ID" value="XM_006696311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SF27"/>
    <dbReference type="STRING" id="759272.G0SF27"/>
    <dbReference type="GeneID" id="18260096"/>
    <dbReference type="KEGG" id="cthr:CTHT_0060580"/>
    <dbReference type="eggNOG" id="KOG1509">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1637">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019220_0_0_1"/>
    <dbReference type="OMA" id="KADATHP"/>
    <dbReference type="OrthoDB" id="5423599at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000039">
        <property type="entry name" value="Threonyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00172">
        <property type="entry name" value="maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF50">
        <property type="entry name" value="THREONINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 16" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="15">
        <location>
            <begin position="104"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGS18043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="798" mass="89078" checksum="2B27D33DE4BAD844" modified="2011-10-19" version="1">MPLLRASHWPRVARVARVACLPLAQLPHPARLTPPSSVILQQYRSCSSCDASSPSLSPNASEDSSRQEPNITKASPDHRTLGVQQELFIQSPFSPGSPIFLPRGALVFNRLLNFLRRQYVKYGFQEVITPTIYKKALWATSGHLENYAEDMYTVTSTSPARRAAELAEEGESEEHEFGLKPMNCPGHCLIFASQTRSYRDLPIRYADFSPLHRNEVSGALSGLTRVRRFHQDDGHIFCRPSQIEGEIASTLDFIRQTYRVLKLGPYRLVLSTRPEKYLGSVEDWDRAEDALRRALDKSGKEWTVSPGDGAFYGPKIDVILKDSDGKEHQTGTIQLDFQLPRRFNLEYTAPAPEHEQRGETTDDPALLNEYGHVRPVLIHRAVLGSAERLMALLIEQYNGRWPLWLNPRQAVVLTVNDTQPVVEWANSVRRVLLGLGLGDGTHGEDKDAPVWPTELAVDLDDSKRTVGLKVREAMVKGYGVIVTVGPKDVADGVVSVNATALCGPEVSEEERQRMSRMVMKPEELKEWISEKVRAYERHPPIHRRRTRTQHPLTAIRPHPQGAPPLDLPILTYLRSKRIILASASPRRRALLSQLGLPNLEVMPSNDPEDIDKKSVSPEEYVSLTAQKKALAVYQEALEKQKEGEEDPAVVIAADTVIATKSQQILEKPKSEQDHIRMLTHLRDTVSHRVLTGICVLAPKHDASHPGYELATHVEETKVFFAQADDGLPDEVIVSYVKTREGCDKAGGYAVQGLGGVVLVERVEGSVDNVIGLPVRRTLQLCEKVVFRQGEGEGEGEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G0SF58</accession>
    <name>G0SF58_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="15">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="15">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ALA1</name>
        <name evidence="19" type="ORF">CTHT_0060890</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14 15">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>tRNA(Ala) + L-alanine + ATP = L-alanyl-tRNA(Ala) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="15"/>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696405.1">
        <property type="nucleotide sequence ID" value="XM_006696342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SF58"/>
    <dbReference type="STRING" id="759272.G0SF58"/>
    <dbReference type="GeneID" id="18260127"/>
    <dbReference type="KEGG" id="cthr:CTHT_0060890"/>
    <dbReference type="eggNOG" id="KOG0188">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004485_5_0_1"/>
    <dbReference type="OMA" id="NKKDNFW"/>
    <dbReference type="OrthoDB" id="2423964at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070143">
        <property type="term" value="P:mitochondrial alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00673">
        <property type="entry name" value="AlaRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.130:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.310.40:FF:000003">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000011">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050058">
        <property type="entry name" value="Ala-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059090">
        <property type="entry name" value="ALA1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777:SF9">
        <property type="entry name" value="ALANINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777">
        <property type="entry name" value="ALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26023">
        <property type="entry name" value="ALA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15 19" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 15" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 15" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="7 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="18">
        <location>
            <begin position="152"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1065"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="948"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="745"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="749"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="864"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="868"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGS18074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1105" mass="123647" checksum="5305E0A52E4B81BF" modified="2011-10-19" version="1">MRFDTALRLLRQRGPRPSGGCSSGCSRCCYRGFQGCHQVGATAPLSHGLQRGAHLGHYVHRSRSFHRFHLFHKTRLAPAPQQPFSVPLNLENFRAVAHLTTTTTPLPQQHRVLLPRLSTGLRVRITPLSLAGRRFYSSRSSTTSPIMTEVKWTGPLVRKTFLDFFAERGHTIVPSSSVVPHNDPTLLFTNAGMNQFKPVFLGTIGKSEPFAQLKRAADTQKCIRAGGKHNDLDDVGKDSYHHTFFEMLGNWSFGDYFKKEAIEWSWELLTKVYGLDPSRLYVTYFEGNPELGLEPDLEAKQLWLDVGVPEDHILPGNMKDNFWEMGDQGPCGPCSEIHYDKVGGRNAAHLVNKDDPLVVEIWNNVFMQFDRQKDKSLKPLPARHIDTGMGFERLVSALQDKTSNYATDIFTPLFDRIQEVTGARPYADKYGKDDADGIDTAYRVVADHIRMLAFAIADGAVPNNIGRGYVVRRVLRRGVRYARKYFKAEIGSFFSSILPALVEQMGEQFPELKKKQNDIKEILDEEEVAFAVTLDRGEKQFEKYASLAVKDGSNKLSGADVWRLYDTFGFPEDLTKLMAEERGLTIDEAEVEVAREKAREASKAVKEAVQTFPKLNVHQIAELENDIGLPRPDSSAKYVKGDIKAKVQLIFTGNEFRKTSKELPPKTPLGLLLDKTNFYAESGGQVADTGRIIIDGVAEFKVLDVQEYGGYIVHNGYLEYGELTAGDEVICEYDELRRQPIRNNHTGTHILNHALREVLGDEVHQKGSLVDQDKLRFDFSHKSAVTLDQIKVIEEMCNEDIRKNLKTYAKDVDLDLARQIEGVRAVFGETYPNPVRVVSIGMDVDELLKNPKNPEWRKYSIEFCGGTHVDNTGLIKDFIIVEESGIAKGIRRIVACTGDGAHQAQRDAKTFAEKLDHIEALEFGPVKQAEIKAAAVELDALAISALTKEELRQRFARIQKEVVDEQKKRQKAESKTALETVQSHFSKEENKNAKFFVGHLPISANAKAISDVITHFKSKDKEKTVYVFAGSKDDAVMHGVYVGTALSSKGITAEQWTAAVTEVIGGKTGGKEPSRQGAGADPSKLDEAVARAEQWLVDKIKELNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFI6</accession>
    <name>G0SFI6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zeta toxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0070960</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697369.1">
        <property type="nucleotide sequence ID" value="XM_006697306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFI6"/>
    <dbReference type="GeneID" id="18261134"/>
    <dbReference type="KEGG" id="cthr:CTHT_0070960"/>
    <dbReference type="HOGENOM" id="CLU_463797_0_0_1"/>
    <dbReference type="OrthoDB" id="2881954at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010488">
        <property type="entry name" value="Zeta_toxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06414">
        <property type="entry name" value="Zeta_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zeta toxin" evidence="4">
        <location>
            <begin position="152"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="221"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="367"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="394"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="416"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="434"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS17751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="588" mass="63209" checksum="6970C954B3926677" modified="2011-10-19" version="1">MSTSASALIVPSTGVYSQPAKSPNGDPHGPSASSLPLPELSSLPSNWHLSRQEQDRILKEVVIPAELPSSNFPLERGDAASKVAFFLLGQTGAGKTRLSKRILKALERHAGIRALEEASYLADGNGVKRGTASESEANDDQPQLQPGDQPASKEKVLHLVADGFKHHHPNYSHCLQQYGSRLAAQLATRAAAEWLYGVCAEAARRGVGRVVVEAACRHHGSSKPRTEVKGEGEGNGAGYAEAKRDEEEPDPATVPALLKLFHKAGYELKIMVLAVPAPLSRLGTMVRYYKRLEEGYGGGGDYLVGSRHYGDTARGEVQGQGQIQEGVFEQVARGVGGTLRLTPKPVHDASYLGVRKAVEWIGDVLLNGSGSDETDGTREHLPEGGKSKDEKNLTADSSWGNVQEGNDGFRERTNEGAGNSAPSNAHTGPERKTNNHHPQGHRTPKAKVRLLILRRKGEVVYDSSLKPSAQHTTRQTLLQGQSVSNSISSTTVTFSPNSNQGWSPVEALNRARGILTPQERHLALEDISFLCAMAHANPSTKINLVELDEIKRELCQLGTYNPEEGSHSGLRGAERVIDLEGAVSSVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFM4</accession>
    <name>G0SFM4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Uricase</fullName>
            <ecNumber evidence="7 10">1.7.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Urate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0071370</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 10">Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 10">
            <text>urate + O2 + H2O = 5-hydroxyisourate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:21368"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="EC" id="1.7.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Purine metabolism; urate degradation; (S)-allantoin from urate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7 10">Belongs to the uricase family.</text>
    </comment>
    <dbReference type="EC" id="1.7.3.3" evidence="7 10"/>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697407.1">
        <property type="nucleotide sequence ID" value="XM_006697344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFM4"/>
    <dbReference type="STRING" id="759272.G0SFM4"/>
    <dbReference type="GeneID" id="18261175"/>
    <dbReference type="KEGG" id="cthr:CTHT_0071370"/>
    <dbReference type="eggNOG" id="KOG1599">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048151_0_0_1"/>
    <dbReference type="OMA" id="ATMYKMS"/>
    <dbReference type="OrthoDB" id="9992118at2759"/>
    <dbReference type="UniPathway" id="UPA00394">
        <property type="reaction ID" value="UER00650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004846">
        <property type="term" value="F:urate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019628">
        <property type="term" value="P:urate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.270.10:FF:000001">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.270.10">
        <property type="entry name" value="Urate Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002042">
        <property type="entry name" value="Uricase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019842">
        <property type="entry name" value="Uricase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03383">
        <property type="entry name" value="urate_oxi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874:SF1">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01014">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000241">
        <property type="entry name" value="Urate_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00093">
        <property type="entry name" value="URICASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00366">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="4 7 10" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000241-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000241-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS17789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="295" mass="33493" checksum="EC56ED95D28608E3" modified="2011-10-19" version="1">MPSLSAARYGKDNVRVYKVHRDEKTGVHTVTEMTVCALVEGDIETSYTKADNSVVVATDSIKNTIYIKAKEFPVNPPELFAAKLGQHFLDKYAHLSVAHIDIKVHRWTRMVIDGEPHPHSFWRDGEETRNVSADISREGITIRSGIRDLTVLKSTGSAFHGFVRDEFTTLPEVWDRIMSTDVDSTWTWKKFNNLAEVEEGVERFNKTYETARNIVFKVFAIDDSASVQATMYRMCEQILEAAPEVDKVAFSLPNKHYFEIDLSWHKGIKNTGKDAEVYMPFPGPNGLIKCEVSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFR2</accession>
    <name>G0SFR2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0071810</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697445.1">
        <property type="nucleotide sequence ID" value="XM_006697382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFR2"/>
    <dbReference type="STRING" id="759272.G0SFR2"/>
    <dbReference type="GeneID" id="18261219"/>
    <dbReference type="KEGG" id="cthr:CTHT_0071810"/>
    <dbReference type="eggNOG" id="ENOG502S8JU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067850_0_0_1"/>
    <dbReference type="OMA" id="EHQDYVW"/>
    <dbReference type="OrthoDB" id="276276at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02883">
        <property type="entry name" value="NUDIX_Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43736">
        <property type="entry name" value="ADP-RIBOSE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43736:SF1">
        <property type="entry name" value="DIHYDRONEOPTERIN TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="37"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="215" mass="23956" checksum="07D69BA76CC490B9" modified="2011-10-19" version="1">MTLPRPLPEGGISFTWHKSVATFNVPLQTFLSTRPLVRAAATGALVFSRAAGEDRVLLIQRAPHDSMPLRWEVPGGACDQEDETLLHSLARELWEEAGLKLKHVVRKVGDEFTFLTRRGLAVTKVTFETEIEEAAPAVVEEGSSKLTLPEVTIDPNEHVRFVWATEEECQAEKIVVSEDGGNEVIKLEFTTKNQKSVVLLGFRLRREDLANGRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFV5</accession>
    <name>G0SFV5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0072270</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697488.1">
        <property type="nucleotide sequence ID" value="XM_006697425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFV5"/>
    <dbReference type="STRING" id="759272.G0SFV5"/>
    <dbReference type="GeneID" id="18261265"/>
    <dbReference type="KEGG" id="cthr:CTHT_0072270"/>
    <dbReference type="eggNOG" id="ENOG502S3UW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066707_0_0_1"/>
    <dbReference type="OMA" id="MLPLYHW"/>
    <dbReference type="OrthoDB" id="63935at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004074">
        <property type="term" value="F:biliverdin reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051606">
        <property type="entry name" value="Polyketide_Oxido-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355:SF2">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="13"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="262" mass="27983" checksum="8E303311D6223BB9" modified="2011-10-19" version="1">MSDASKKVILFLGATGGCGLSALRRSLAAGHTCIALCRTPRKLLLLLGYSEPSSTSPAPPNPPPPNLHILQGNAHSGSSLLHALTVSGSFSAHLVDIVVTSLGARPTLKGMDDPHVCERGVQALLDALQRLRKDHGLEETSQGVPHIVAVSSTGLSERTRDLPWLMIPMYRLLLGTAHADKRKMEKMLIESGEKFTVVRGSLYAGSGEGKIRVGVEDLVKGVVESTAIGYTISREDVGRWVFEEIVEGEAGKWVGKAATITY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFW8</accession>
    <name>G0SFW8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acyl-CoA thioesterase-like N-terminal HotDog domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0072410</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697501.1">
        <property type="nucleotide sequence ID" value="XM_006697438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFW8"/>
    <dbReference type="STRING" id="759272.G0SFW8"/>
    <dbReference type="GeneID" id="18261279"/>
    <dbReference type="KEGG" id="cthr:CTHT_0072410"/>
    <dbReference type="eggNOG" id="KOG3016">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051867_1_0_1"/>
    <dbReference type="OMA" id="DMTGTFI"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF64">
        <property type="entry name" value="ACYL-COA THIOESTERASE (AFU_ORTHOLOGUE AFUA_1G12060)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="4">
        <location>
            <begin position="65"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS17883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="394" mass="44002" checksum="180C1E38FEAA5521" modified="2011-10-19" version="1">MATPSEPAALSQTRKSKLPPEPLQQNLDLIPLPRQGETRRFMAARAAYLPGSDIEIDGELPMNRANAFGGHVYGQSALAAAWTWREIERERGAKPEERLDLHTIHGFFTRPGARDRPFLYDVTPLTSTRTFASLSVIARQPTQSSTAGPAAINQGFPLADASLPLAQPAFTAMISLKQPEHDSAGVETQEEPPQVRFKEILESRRPEEWPPAPPVDLSAIVAFVGAHQEGRFPVAIMKKVDMRAWNRGKPLHERRELVLYKLHAPLPVEDEGKWDANAHVVAHAYVADRNGLLMVANNMGFGFTLEKAASLSYSFVMHVGAKEAVMREEEGWWVQELWFPRTGRGRGIVESKIWSPRGVHVATEYQDGMIRGYERGFVDEGEEREEGEARESKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>G0SG03</accession>
    <name>G0SG03_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0072780</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697536.1">
        <property type="nucleotide sequence ID" value="XM_006697473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SG03"/>
    <dbReference type="GeneID" id="18261316"/>
    <dbReference type="KEGG" id="cthr:CTHT_0072780"/>
    <dbReference type="HOGENOM" id="CLU_894288_0_0_1"/>
    <dbReference type="OrthoDB" id="4842715at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409152" description="Reverse transcriptase domain-containing protein" evidence="1">
        <location>
            <begin position="34"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="34562" checksum="31DFDD627A7CE3F8" modified="2011-10-19" version="1">MSLETWYLPLRLLALRMTAAALCSDLLPPDVAGAIPSRSALDLVQSLVHDAETMARQGYYGFLVTLDVDSAYPSVHSSILGEVLADQGWPRWLVNQLCTKARGLDLRVNPNKTEVFYVPSPPPPRGTGATRGRTDPTTISTQVERTSFLPGKSIKWLGVSLELKLSPAIQAAARAAATASVVRLVKRLSITRLRGFPPSADSKIIDAVVTPSLLYGMVQLDTGPTRAAVNGRLVPLDLRRCARPSPRSRMRRPEVISQVWLTVPTTWLWWLAGLYPEYLLDKEQARWRARAEVLPANHFLWIRLARPPFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0SG33</accession>
    <name>G0SG33_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0064870</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696790.1">
        <property type="nucleotide sequence ID" value="XM_006696727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SG33"/>
    <dbReference type="GeneID" id="18260525"/>
    <dbReference type="KEGG" id="cthr:CTHT_0064870"/>
    <dbReference type="eggNOG" id="ENOG502QWD6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032662_0_0_1"/>
    <dbReference type="OMA" id="PSNQMFE"/>
    <dbReference type="OrthoDB" id="5440at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436:SF3">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="POLYKETIDE CYCLASE SNOAL-LIKE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS17172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="399" mass="44402" checksum="F04105F049C81989" modified="2011-10-19" version="1">MAPKFPSAPAVQVSPDITIQPPLSRRGGGPGLVLVVSTAVDLSEDDKTLDPPPLKKWAEESYAVAQVLVNDSFDDVQEKLSTAIAELKKLPELTGDKFGLVVIHDKDTGKLVEAIRFHSEIVASVFYGCRPTSEPPVPALVHLGAKEAPKSEVKATVYTYPSATGFFNIPASPDYKASASSVSHTRSLTFLKPLMDGPYFDLEKIWEEHTYFEFADRSVEETMATMVDQPYVNHIPVLTGGIGRAHLTNFYRDHFIFSNPRDTELELVSRTVGIDRIVDEFLLNCTHDCEIDWLIPGIPPTHKKLSIPFTSIVNIRGDRLYHEHIAWDQGTVLRQLGLLPEYLPFPYPLPEGHRLASSKQLEFRVPVAGVETAKKLTDENACPSNELLQFTVREAETRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGX2</accession>
    <name>G0SGX2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0067880</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697079.1">
        <property type="nucleotide sequence ID" value="XM_006697016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGX2"/>
    <dbReference type="GeneID" id="18260826"/>
    <dbReference type="KEGG" id="cthr:CTHT_0067880"/>
    <dbReference type="eggNOG" id="ENOG502S0NF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033551_1_0_1"/>
    <dbReference type="OMA" id="NHAWLAL"/>
    <dbReference type="OrthoDB" id="5552418at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="390" mass="42411" checksum="82B830EF35395617" modified="2011-10-19" version="1">MDDNRGQRRQNEPPIYSASSSRHHQSLHDRSQPRQPFPGAAEDRFRPAPLQTSASGAARGMGGSSYSGYYQDTSATGFPTTAMPQGAMSYHHSAADYGQPDSRQTQSFGGTYTPAMMYNVQQTGGPQSAAVYDASQQFPSRQAAGLPMMTTDVTAPYFSSEPANPTAATSALQAQTASSSTPQVYQQPGLHAGYSTGSMAAIGGMTTQTTAAGDVRMEEEYHHAQSAGGLDEAYAQYQTALKEVFTNIKNGILATASESLLNVSDWLLSHVVELGLTSDDQNLHGERIKLWNDFNHAWLAMFQRQKEMLQAEQPPPRPQTMISQEGLIKMGKELVRLCDSIERHGLVDYQYGVWEEQIIDILDECLTLYEAQQSNTSGGGGDGASSSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0SH32</accession>
    <name>G0SH32_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0068510</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697139.1">
        <property type="nucleotide sequence ID" value="XM_006697076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SH32"/>
    <dbReference type="STRING" id="759272.G0SH32"/>
    <dbReference type="GeneID" id="18260889"/>
    <dbReference type="KEGG" id="cthr:CTHT_0068510"/>
    <dbReference type="eggNOG" id="ENOG502RZPZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013481_0_1_1"/>
    <dbReference type="OMA" id="HFLVEYN"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF50">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="3">
        <location>
            <begin position="328"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="465"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS17521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="692" mass="74794" checksum="95A6F714E1DBBB5D" modified="2011-10-19" version="1">MEFMAGYAAAKAPYSTYQVEPASQSHRSNINKPTRSNSTSGTHKKRSRIPGHARTNSASTSGSGSGSGSGPGARNDRDDVSGVRTDPVTSATNLLSPVSAGAAGAPTGRLSAEHQRLNQQQQHHHLPLPHHHNNTLVRRASARDRDRDHDRDRDRDRASSKHHQDKHLPATPRLNNQDAAPSISLGPATAAFEPSSLRAAGPVSISLTSPGSAKHSATMLTDMMMGTRAAVGAGSMPRADSVSSVSGTTTTSNRTVFLGDHGVGPELVQRPFVVRNGRTYIADPTLPYPLPVDLEELHRQSLKTMLLMQLFGRPICSPGFANNPPSRVLDVGCGTGFWSMMCYRHYEARGQAADMSFTGIDIVPLCPSGPVAAGTDSGNSNPQVAPVQGMNWRFVQHDLRKLPLPFPDASFDFVMVKDMSLATTTGTMQQSLIEEYIRVLAPGGSLEIWETDHLLRMLRPHIPEPATTVIPQPTDQKQQQQSSDSNHHNSDDSPPDGDDPSHHETFSPTDVGAYLMTSKTPLSTPLNNFLVEYNAWVTRALEARQLPVMPCTLMSPLLLQEAEALTGIGSRRLAVPLSEIRWEREGVGGVVTKDGKSYIDSTGAGSKGKYTAKDGNPSGGVLQPAAAALRRAALVTVVQQIQSLEPVLREVSGKSQDEWDTWIGKMMGDLVRENGTNWGECLEVGVWWARKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHB5</accession>
    <name>G0SHB5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peroxisomal membrane protein pex17-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0069430</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697222.1">
        <property type="nucleotide sequence ID" value="XM_006697159.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0SHB5"/>
    <dbReference type="GeneID" id="18260981"/>
    <dbReference type="KEGG" id="cthr:CTHT_0069430"/>
    <dbReference type="eggNOG" id="ENOG502S1QP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016177_0_0_1"/>
    <dbReference type="OMA" id="LMVQWRQ"/>
    <dbReference type="OrthoDB" id="2357318at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055334">
        <property type="entry name" value="PEX8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39214">
        <property type="entry name" value="MICROBODY (PEROXISOME) BIOGENESIS PROTEIN PEROXIN 8 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39214:SF1">
        <property type="entry name" value="MICROBODY (PEROXISOME) BIOGENESIS PROTEIN PEROXIN 8 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26001">
        <property type="entry name" value="Pex8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="694"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="728" mass="80425" checksum="B98177D3A48603F1" modified="2011-10-19" version="1">MDRLLTSVLQQYQDVHDDARTDNIYALTTTLLTNLSNPLNVSLLTSQLLTAPAIWARGDGIRACFRIISLFNTAAIHVRRNELENAKLKDAPAQPPPQSYAAGFAPPPQQPQRRGGGISSNAWAAAVLKGADDQSVRWQHLLVFTGVLLGFEGNNRSSLSSNMRNTLEKAVVTAANLAVRNRAPEPPAPPSPVALALNYAFPLLAESVRAELDSDALVPVLAQAMLGPDCLEEGVFVASIDIDVKQVDEKFHWAENSPSFLHISQLERKPLVSGLGPLSRLLAHAVQHSRNSQAVMQLLDDLVAFTGRLLQYWESCKLSELEMSEEEFFLTPEMLQTTWTALWLFLKKIMYAVVAVLHAIVARSLIDRHMRQDAIAPLVAHKTLLALRNLYFISSRNSAYAFQVYSFTYLTSLDTLSRYPDAAASFLSSIKPTATAPPANANIGNANGSLPAHPLHRILDLYYLNVAEHLPLNLPTPSCDSLIIQPALIYLTPSSITSPFHXXXXXXXSRRHTPPCWPHITPRQFRLAFKTVLQIVSPPFPLSKSHPEMAETLLEMVRFRAATSKSDPVATAILPSQQRDGEQQQEEPMSEQSTLVLTLLDSLPYLSDAIFEEWLTLAARAVHDISGPDAARLKEAAKRRFWDVLSSGEMDVERATRALAWWGTRGGERGWVLFGRFPEGETIEGDCVIDVPGGQEAAKEGGEKYLMSGALPKDEKEEGKEEKIRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHK8</accession>
    <name>G0SHK8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0070390</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays an important role in cellulose degradation. Shows hydrolytic activity against several glycosidic compounds.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697315.1">
        <property type="nucleotide sequence ID" value="XM_006697252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHK8"/>
    <dbReference type="STRING" id="759272.G0SHK8"/>
    <dbReference type="GeneID" id="18261077"/>
    <dbReference type="KEGG" id="cthr:CTHT_0070390"/>
    <dbReference type="eggNOG" id="KOG0626">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001859_1_2_1"/>
    <dbReference type="OMA" id="HGSNDFY"/>
    <dbReference type="OrthoDB" id="65569at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080079">
        <property type="term" value="F:cellobiose glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000011">
        <property type="entry name" value="Cytosolic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="GH_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF36">
        <property type="entry name" value="LP05116P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS17697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="500" mass="56512" checksum="6239CDEC0F9D0C65" modified="2011-10-19" version="1">MSLPSDFLWGFATAAYQIEGSTDVDGRGPSIWDTFCAIPGKIADGSSGVVACDSYKRTKEDIALLKELGAKCYRFSISWSRVIPLGGRNDPINQAGIDHYRQFVDDLLEAGITPFITLFHWDLPDALDKRYGGLLNKEEFTADFENYARLMFKSIPKCKHWITFNEPWCSAINGYNLGIFAPGHTSDRNKSPVGDSAREPWIVGHNILIAHGKAVKVYREEFKPTQGGEIGITLNGDATYPWDPEDPADIEACDRKIEFAISWFADPIYFGDYPASMRKQLGERLPTFTEEEVALVKGSNDFYGMNHYTANYIKHRKGTPPEDDFLGNLETLFYDKNGNCIGPETQSFWLRPNAQGFRNLLNWLSKRYNYPKIYVTENGTSLKGESDLPLEQALEDDFRCKYFHDYVHAMAKAVEEDGVNVKGYMAWSLLDNFEWADGYVTRFGVTYVDYKDNCKRYPKKSARQMKPLFDSLIKKAEVEAAEAAKPAPAVAEEQAEEADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0SI47</accession>
    <name>G0SI47_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Maintenance of telomere capping protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0074470</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697699.1">
        <property type="nucleotide sequence ID" value="XM_006697636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SI47"/>
    <dbReference type="STRING" id="759272.G0SI47"/>
    <dbReference type="GeneID" id="18261485"/>
    <dbReference type="KEGG" id="cthr:CTHT_0074470"/>
    <dbReference type="eggNOG" id="ENOG502QU4J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034224_0_1_1"/>
    <dbReference type="OMA" id="RIHLVHD"/>
    <dbReference type="OrthoDB" id="5594977at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018814">
        <property type="entry name" value="DUF5427"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28265">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28265:SF1">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10310">
        <property type="entry name" value="DUF5427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="512" mass="55420" checksum="0BA14A9F37DB147C" modified="2011-10-19" version="1">MSKRAKDNKSAPTDDELGELFEGIGDDASIRKSSSSSTKPKTSRAKAVEDDILADLENQLGEAVADLPKRPHTPRVRDAAATKASPASKAARSQAQEEKKTPTPPLQTPVAEGASSQSQNATPEPQKKHSGGSWWGGLLSTATAAMKQAEAAVNAVKEIQQAEEAKKWAQQITGNVGALKGLGNELRHRALPTFTNILHTLAPPISSHERLLIHITHDLVGYPSLDPLIYSVFSRVMSQVEGGDLMVIQRGQESSHRSSSEHHKSSFFSQPPFGWRDGPWWRQDDSPRSIGIVPGLVEGTKLCRASAEAYAHEYFAANGGIEVARQRASEPLSESNPVRSSDIFLSVQAISVPSDGALFVGSAAAEKEKAASDVKEEQEDAEGGVCFAVYVFDPVHEIRYSTVSQTVPTRWIRWLDAPPAPASREEEGNEYEKEFGRLPEEIREIVETGGVDPREWVSEWVEEVLSLAVGIVAQRYVARRMGVGEGGIGKGKQKVEDVVQEGGNEAARAGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0RXS9</accession>
    <name>G0RXS9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0000260</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988030">
        <property type="protein sequence ID" value="EGS24095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690581.1">
        <property type="nucleotide sequence ID" value="XM_006690518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RXS9"/>
    <dbReference type="STRING" id="759272.G0RXS9"/>
    <dbReference type="GeneID" id="18254064"/>
    <dbReference type="KEGG" id="cthr:CTHT_0000260"/>
    <dbReference type="eggNOG" id="KOG2223">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009825_0_0_1"/>
    <dbReference type="OMA" id="WSKAIGN"/>
    <dbReference type="OrthoDB" id="289721at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000034">
        <property type="entry name" value="TBC (Tre-2/Bub2/Cdc16) domain family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053949">
        <property type="entry name" value="SBE2/SBE22_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF15">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 12 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22874">
        <property type="entry name" value="SBE2_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="471"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS24095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="747" mass="83207" checksum="76ADA70F5705EE61" modified="2011-10-19" version="1">MMIYERPLHDTSLPGPGSPPGMTASKSSKSSSLASLPEEDSALADANHFEEIGLDDPQVDLHAVSDLKSTANPYSRSISDLRSVTKKPVVASTPRLPQFVRDTPRARPTRDFSPSQPSRPTFPPRSPNGRVASMGLLSDPVRTRNLGPPSRSQTSLSRHRSPSPGIALSPRDPALPMKPRRSSWQSNRDRKSAMELELECDEDDGDEIPDGLILDNVPLSPRPPSERIRSQPPSKSPSPERAPKERIRSVGNGTPPVATAQGCLRSPTWKTDSAATSPGSTPGSRVTSPVLVRQKSWTTALNQLNAEAKALTEKLEEHAEEIEKKEIEKKEQQLKSQRASTGSLPTFRRRSEDSKPRVKSALPELPPLRRSNIMIDPLPISKEKEAVLSRTRPSWLPPKDPAEERRHLREYQKMMQQSLEAERKREAAKRAKSETRDVVVDSVMQIWERDIIPRWNEAIHERRTRDLWWKGIAPRSRGLVWPRAIGNDLGLTKTSFEAALNRAREVEQRVKTGHGTPEDMRAVNWFSEISRDVRERTWPDLRIFQPGGPLHQSLLDVLRAYAMYRSDIGYVPGCNTIAALLLLNLPTPIDAFISLANVLNRGLPVSFFSHDVGGKTSAYNLLLQNLAQKSPTLHEHLTTKIPSGSDLDRYLNPIFTGLFTRHLALDEVTRLWDVYVFEGDALLIRAGVAYLLQKEMALLGTKTVAEVREVLGTAPDTGDGRAYCPKVMGGNGEEEKWMQAVRDAGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0RXU3</accession>
    <name>G0RXU3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0000400</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988030">
        <property type="protein sequence ID" value="EGS24109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690595.1">
        <property type="nucleotide sequence ID" value="XM_006690532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RXU3"/>
    <dbReference type="GeneID" id="18254078"/>
    <dbReference type="KEGG" id="cthr:CTHT_0000400"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_1_1"/>
    <dbReference type="OMA" id="WGKLFTF"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF199">
        <property type="entry name" value="MFS EFFLUX TRANSPORTER INPD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS24109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="415" mass="44503" checksum="871294D0E591841B" modified="2011-10-19" version="1">MPPLSEEPTLAPNTASQSDDGKRTSAGKQTNMDTGVTQAVEKPVQDEKQDELTRQPIAKPTSGKKLDKVDTRDDGQKYPKGTKLYMIILALCLSVFVLALDNSIIATAFPKITDQFQSLSDVACLPPYYRCSATPFRPALYVFIKFVFLSSIFLFEVGSLICGVAQNSVTLIAGRAVAGIGSAGIFSGALTILAYSVPLAKRPVYSGAISSMYGVATLQWGGTEYNWNNWRIMLLFCVFGIFIIVFIIDQCVVASIGYGLTTLLEPDSSDAEWIGYQIIIGIGVGAGFQQPLMAVQTVLVILDIPTGTAVIVFLQTLGGALFVSVAQNIFANKLVHYVAKYVPELGDAYFVLAVGATNVKEVVPSEFLPGVKQAFNDALTQTSVLFAALAATSILGAAFVEWKSVRGKKVEMVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0RXX5</accession>
    <name>G0RXX5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Gamma-glutamyltranspeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0004630</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>an N-terminal (5-L-glutamyl)-[peptide] + an alpha-amino acid = 5-L-glutamyl amino acid + an N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the gamma-glutamyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691003.1">
        <property type="nucleotide sequence ID" value="XM_006690940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RXX5"/>
    <dbReference type="STRING" id="759272.G0RXX5"/>
    <dbReference type="MEROPS" id="T03.011"/>
    <dbReference type="GeneID" id="18254501"/>
    <dbReference type="KEGG" id="cthr:CTHT_0004630"/>
    <dbReference type="eggNOG" id="KOG2410">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014813_4_0_1"/>
    <dbReference type="OMA" id="SFWPRTW"/>
    <dbReference type="OrthoDB" id="1081007at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.40:FF:000008">
        <property type="entry name" value="Gamma-glutamyltranspeptidase (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.130:FF:000005">
        <property type="entry name" value="Gamma-glutamyltranspeptidase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF62">
        <property type="entry name" value="GLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409127" evidence="12">
        <location>
            <begin position="23"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="368"/>
            <end position="370"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="420"/>
            <end position="421"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS23761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="541" mass="58943" checksum="3D4B9B76D45E9061" modified="2011-10-19" version="1">MYRPPSLAWWLWSLSQLTAIPALPTGSYQEQRTISTGAVCNGSRGAVASESAICSKIGVDTIAIGGTAADAMVATTLCVGVIGMYHSGIGGGGFMLVRDAHGRYESIDYRETAPAAASQDMYAHDANASVFGGLAVAVPGELKGLAYLHQKYGVLPWRTLVMPAVRVARDGFPVTEDLVRYMKVASQNNNTFLVDDPIWAEDFAPNAESMIKFIQERNGIMTLQDLKDYSLEIREPLNITYGPYRLYTTEAPSSGAVMFNILKTMDQYPPEDLTNINLTTHRFVEAMKFAYGARLELGDPDFLKNMSDYQKYMLSDKTAKDTRGRIRDNETQPVDVYNPNNTYTTDGHGTSHIVTADASGLTVTSTTTINLLFGAQIMTPDTGIILNNEMDDFSQPNRNNSFGFAPSQANFIAPRKRPLSSISPIIAEHANNGTVFFATGAAGGSRIISATVQVAWRLLSFSMSMHDAIAAPRVHHQLMPDVLKVETGFDKGVAEALKEKGHVVEWMEPGLSAVQGIMRLWDGTFDAVGETRQINSGGYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0RXY7</accession>
    <name>G0RXY7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase III subunit RPC9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0004750</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPC9 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691015.1">
        <property type="nucleotide sequence ID" value="XM_006690952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RXY7"/>
    <dbReference type="STRING" id="759272.G0RXY7"/>
    <dbReference type="GeneID" id="18254513"/>
    <dbReference type="KEGG" id="cthr:CTHT_0004750"/>
    <dbReference type="eggNOG" id="KOG4168">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092529_3_1_1"/>
    <dbReference type="OMA" id="WGMHNLA"/>
    <dbReference type="OrthoDB" id="1746530at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006590">
        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038846">
        <property type="entry name" value="RPC9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15561">
        <property type="entry name" value="CALCITONIN GENE-RELATED PEPTIDE-RECEPTOR COMPONENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15561:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00657">
        <property type="entry name" value="RPOL4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb4/RPC9 core" evidence="8">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="133"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS23773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="163" mass="18408" checksum="193D6B762E6DC52E" modified="2011-10-19" version="1">MKILESQNALLSNYEVYQHIVDLRKRNKTQNRRVPGNAHHIMTEVISYLRTQPSPLAKQDETQAYSAEAISRLLERLREANLPSELTKGEVLSILNLRPTNSAVLSTAIEDMEERFTEDEQNRIVDIIVEVLGRDDPEGQEEGADGEGEAMEEDVVPSIENGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZ01</accession>
    <name>G0RZ01_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GTP-binding protein RHO3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0001180</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690671.1">
        <property type="nucleotide sequence ID" value="XM_006690608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZ01"/>
    <dbReference type="STRING" id="759272.G0RZ01"/>
    <dbReference type="GeneID" id="18254156"/>
    <dbReference type="KEGG" id="cthr:CTHT_0001180"/>
    <dbReference type="eggNOG" id="KOG0393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_21_2_1"/>
    <dbReference type="OMA" id="THTIMLC"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017157">
        <property type="term" value="P:regulation of exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000780">
        <property type="entry name" value="Rho GTPase Rho3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS23429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="220" mass="24563" checksum="AC71BE0FD4282320" modified="2011-10-19" version="1">MPCGLGGTKTVQRKLVLLGDGACGKTSLLNVFTRGYFPTVYEPTVFENYVHGGLSEPSGANKQWLTGVDIFVDNVHIELSLWDTAGQEEFDRLRSLSYDDTDLIMLCFSVDSKDSLENVESKWVSEIADNCPGVKLVLVALKCDLREQEEEDTNEDGTPREKKPMITYEQGLEVARRIHALRYLECSAMRNRGVNEAFTEAARVALSVKKESDQGKCIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZ39</accession>
    <name>G0RZ39_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">3-oxo-5-alpha-steroid 4-dehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0001600</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690709.1">
        <property type="nucleotide sequence ID" value="XM_006690646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZ39"/>
    <dbReference type="STRING" id="759272.G0RZ39"/>
    <dbReference type="GeneID" id="18254198"/>
    <dbReference type="KEGG" id="cthr:CTHT_0001600"/>
    <dbReference type="eggNOG" id="KOG1638">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065395_0_0_1"/>
    <dbReference type="OMA" id="PHYALEW"/>
    <dbReference type="OrthoDB" id="5788137at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003865">
        <property type="term" value="F:3-oxo-5-alpha-steroid 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016636">
        <property type="entry name" value="3-oxo-5-alpha-steroid_4-DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF43">
        <property type="entry name" value="STEROID 5-ALPHA-REDUCTASE DET2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015596">
        <property type="entry name" value="5_alpha-SR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="7">
        <location>
            <begin position="127"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="7">
        <location>
            <begin position="217"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS23467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="302" mass="34933" checksum="8D36C9B0E3E322A7" modified="2011-10-19" version="1">MPTTTEGLIPNWFPPNRENYDLILTLWKLFPFFSSLQWLIPWYGMGKTSIPHSPLNLPGRLAWLTMEIPGFLTLLYHLYVLPSQLPLPPSPDGSLPWQTQTLAFLFVFHYIYRAILFPFLQPSMSPVHLFIWLLGVTFQLVNGTVIGAWLAGYGPMYYNHSPAQTPISQFALGLIVFYLGLASNYFHDDHLREIRRRVLRRQQLAAQKPDDSPDAPKSVEKHYEIPQAGLFKVVLYPHYLSEWIEWVGYWIAAGWGCVPARCFVLNEVTAMLPRAVRGRQWYVERFGEETVGRRWAVIPGVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZE9</accession>
    <name>G0RZE9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0002720</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="476" last="476">
            <title>High-resolution structures of a thermophilic eukaryotic 80S ribosome reveal atomistic details of translocation.</title>
            <authorList>
                <person name="Kisonaite M."/>
                <person name="Wild K."/>
                <person name="Lapouge K."/>
                <person name="Ruppert T."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="35079002"/>
            <dbReference type="DOI" id="10.1038/s41467-022-27967-9"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.90 ANGSTROMS)</scope>
    </reference>
    <reference evidence="11 12 13" key="3">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e56910" last="e56910">
            <title>Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation during pre-60S biogenesis.</title>
            <authorList>
                <person name="Lau B."/>
                <person name="Huang Z."/>
                <person name="Kellner N."/>
                <person name="Niu S."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
                <person name="Cheng J."/>
            </authorList>
            <dbReference type="PubMed" id="37129998"/>
            <dbReference type="DOI" id="10.15252/embr.202356910"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <reference evidence="15 16 17" key="4">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e57984" last="e57984">
            <title>Structural insights into coordinating 5S RNP rotation with ITS2 pre-RNA processing during ribosome formation.</title>
            <authorList>
                <person name="Thoms M."/>
                <person name="Lau B."/>
                <person name="Cheng J."/>
                <person name="Fromm L."/>
                <person name="Denk T."/>
                <person name="Kellner N."/>
                <person name="Flemming D."/>
                <person name="Fischer P."/>
                <person name="Falquet L."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="37921038"/>
            <dbReference type="DOI" id="10.15252/embr.202357984"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.12 ANGSTROMS)</scope>
    </reference>
    <reference evidence="9 10" key="5">
        <citation type="journal article" date="2023" name="Nat. Struct. Mol. Biol." volume="30" first="670" last="677">
            <title>Structural inventory of cotranslational protein folding by the eukaryotic RAC complex.</title>
            <authorList>
                <person name="Kisonaite M."/>
                <person name="Wild K."/>
                <person name="Lapouge K."/>
                <person name="Gese G.V."/>
                <person name="Kellner N."/>
                <person name="Hurt E."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="37081320"/>
            <dbReference type="DOI" id="10.1038/s41594-023-00973-1"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.20 ANGSTROMS)</scope>
    </reference>
    <reference evidence="14" key="6">
        <citation type="journal article" date="2024" name="Nat. Commun." volume="15" first="716" last="716">
            <title>Methionine aminopeptidase 2 and its autoproteolysis product have different binding sites on the ribosome.</title>
            <authorList>
                <person name="Klein M.A."/>
                <person name="Wild K."/>
                <person name="Kisonaite M."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="38267453"/>
            <dbReference type="DOI" id="10.1038/s41467-024-44862-7"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.10 ANGSTROMS)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL27 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690819.1">
        <property type="nucleotide sequence ID" value="XM_006690756.1"/>
    </dbReference>
    <dbReference type="PDB" id="7OLC">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="LZ=1-135"/>
    </dbReference>
    <dbReference type="PDB" id="7OLD">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="LZ=1-135"/>
    </dbReference>
    <dbReference type="PDB" id="7Z3N">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="LZ=1-135"/>
    </dbReference>
    <dbReference type="PDB" id="7Z3O">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.30 A"/>
        <property type="chains" value="LZ=1-135"/>
    </dbReference>
    <dbReference type="PDB" id="8I9X">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="LZ=1-135"/>
    </dbReference>
    <dbReference type="PDB" id="8I9Y">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="LZ=1-135"/>
    </dbReference>
    <dbReference type="PDB" id="8I9Z">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="LZ=1-135"/>
    </dbReference>
    <dbReference type="PDB" id="8IA0">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="LZ=1-135"/>
    </dbReference>
    <dbReference type="PDB" id="8OO0">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="LZ=1-135"/>
    </dbReference>
    <dbReference type="PDB" id="8PV1">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.56 A"/>
        <property type="chains" value="LZ=1-135"/>
    </dbReference>
    <dbReference type="PDB" id="8PV2">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.63 A"/>
        <property type="chains" value="LZ=1-135"/>
    </dbReference>
    <dbReference type="PDB" id="8PV3">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="LZ=1-135"/>
    </dbReference>
    <dbReference type="PDB" id="8PV4">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="LZ=1-135"/>
    </dbReference>
    <dbReference type="PDB" id="8PV5">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.86 A"/>
        <property type="chains" value="LZ=1-135"/>
    </dbReference>
    <dbReference type="PDB" id="8PV6">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.94 A"/>
        <property type="chains" value="LZ=1-135"/>
    </dbReference>
    <dbReference type="PDB" id="8PV7">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.12 A"/>
        <property type="chains" value="LZ=1-135"/>
    </dbReference>
    <dbReference type="PDB" id="8PV8">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.91 A"/>
        <property type="chains" value="LZ=1-135"/>
    </dbReference>
    <dbReference type="PDB" id="8PVK">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.55 A"/>
        <property type="chains" value="LZ=1-135"/>
    </dbReference>
    <dbReference type="PDB" id="8PVL">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.19 A"/>
        <property type="chains" value="LZ=1-135"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZE9"/>
    <dbReference type="EMDB" id="EMD-12976"/>
    <dbReference type="EMDB" id="EMD-12977"/>
    <dbReference type="EMDB" id="EMD-14479"/>
    <dbReference type="EMDB" id="EMD-14480"/>
    <dbReference type="EMDB" id="EMD-17004"/>
    <dbReference type="EMDB" id="EMD-17950"/>
    <dbReference type="EMDB" id="EMD-17951"/>
    <dbReference type="EMDB" id="EMD-17952"/>
    <dbReference type="EMDB" id="EMD-17953"/>
    <dbReference type="EMDB" id="EMD-17954"/>
    <dbReference type="EMDB" id="EMD-17955"/>
    <dbReference type="EMDB" id="EMD-17956"/>
    <dbReference type="EMDB" id="EMD-17957"/>
    <dbReference type="EMDB" id="EMD-17969"/>
    <dbReference type="EMDB" id="EMD-17970"/>
    <dbReference type="EMDB" id="EMD-35287"/>
    <dbReference type="EMDB" id="EMD-35288"/>
    <dbReference type="EMDB" id="EMD-35289"/>
    <dbReference type="EMDB" id="EMD-35290"/>
    <dbReference type="SMR" id="G0RZE9"/>
    <dbReference type="STRING" id="759272.G0RZE9"/>
    <dbReference type="GeneID" id="18254310"/>
    <dbReference type="KEGG" id="cthr:CTHT_0002720"/>
    <dbReference type="eggNOG" id="KOG3418">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067359_0_1_1"/>
    <dbReference type="OMA" id="NQWFFTK"/>
    <dbReference type="OrthoDB" id="2365484at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06090">
        <property type="entry name" value="KOW_RPL27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.770:FF:000001">
        <property type="entry name" value="60S ribosomal protein L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001141">
        <property type="entry name" value="Ribosomal_eL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018262">
        <property type="entry name" value="Ribosomal_eL27_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041991">
        <property type="entry name" value="Ribosomal_eL27_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038655">
        <property type="entry name" value="Ribosomal_eL27_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10497">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01777">
        <property type="entry name" value="Ribosomal_L27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01107">
        <property type="entry name" value="RIBOSOMAL_L27E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7 8 9" id="KW-0002">3D-structure</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS23577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="7OLC"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="7OLD"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="7Z3N"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="7Z3O"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="8I9X"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="8I9Y"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="8I9Z"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="8OO0"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="8PV1"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="8PV2"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PDB" id="8PV3"/>
        </source>
    </evidence>
    <sequence length="135" mass="15770" checksum="E41AD2468D6F9BE5" modified="2011-10-19" version="1">MKFLKTSRVCLVTRGRYAGKKVVIIQPVDQGTKSHPYGHALVAGIERYPSKITRRMSKARIEKRSKIKPFIKVINYNHLMPTRYTLELEGLKAVINADTFKEPSQREEAKKTVKKVLEDRYNSGKNRWFFTPLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZQ2</accession>
    <name>G0RZQ2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Glutamine synthetase</fullName>
            <ecNumber evidence="3 11">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0003770</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>L-glutamate + NH4(+) + ATP = L-glutamine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9 10">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="3 11"/>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690922.1">
        <property type="nucleotide sequence ID" value="XM_006690859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZQ2"/>
    <dbReference type="STRING" id="759272.G0RZQ2"/>
    <dbReference type="GeneID" id="18254415"/>
    <dbReference type="KEGG" id="cthr:CTHT_0003770"/>
    <dbReference type="eggNOG" id="KOG0683">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036762_1_1_1"/>
    <dbReference type="OMA" id="NRHRCLE"/>
    <dbReference type="OrthoDB" id="1936100at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.70:FF:000004">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000004">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050292">
        <property type="entry name" value="Glutamine_Synthetase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852:SF57">
        <property type="entry name" value="GLUTAMINE SYNTHETASE 2 CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51986">
        <property type="entry name" value="GS_BETA_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS beta-grasp" evidence="13">
        <location>
            <begin position="25"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="GS catalytic" evidence="14">
        <location>
            <begin position="113"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="41"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS23680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="360" mass="40219" checksum="592696866F932D70" modified="2011-10-19" version="1">MASSSFTSNAPNLQKYLDLDQNGKIIAEYIWIDSEGQTRSKARTLPEKEGGYKPEDLPTWNFDGSSTGQAPGDNSDVYLKPVAVFPDPFRRGKNILVLAECWDADGTPNKYNHRHETVKLMEAHAEHEPWFGLEQEYTMLDLNDRPYGWPPNGYPAPQGPYYCGVGAGKVVQRDIVEAHYRACLYAGIKISGINAEVMPAQWEFQVGPCVGIEMGDQLWVARYLLHRIAEEFGVKISVHPKPIPGDWNGAGLHTNFSTKEMRDPENGMKAIEAAIQKLGTRHAEHIAVYGEENEKRLTGKHETGRIDQFTYGVANRGSSIRIPREVAAKGYGYFEDRRPASNADPYQITGIIMETIFGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZX6</accession>
    <name>G0RZX6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0007980</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691328.1">
        <property type="nucleotide sequence ID" value="XM_006691265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZX6"/>
    <dbReference type="STRING" id="759272.G0RZX6"/>
    <dbReference type="GeneID" id="18254836"/>
    <dbReference type="KEGG" id="cthr:CTHT_0007980"/>
    <dbReference type="eggNOG" id="KOG1437">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026522_0_1_1"/>
    <dbReference type="OMA" id="TSILAHF"/>
    <dbReference type="OrthoDB" id="7700931at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF125">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN YLR001C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408791" description="FAS1 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="118"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="338"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS23137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="567" mass="63719" checksum="A78365D939044A27" modified="2011-10-19" version="1">MRRLSMIAVTTAVVISALASPVPDRSQVPFACEAKEGQSYCSLSPKKDPVQAWWDCLPWEQARELYSDVLGEDLIRDIHLSHLVDENIDLSHAYASDEDHHPDHGHGHHGHRGPSFPDKTIYEVISECEHVSRFFKLVEEHDGIKELLDDDKHNHTLLLPTNGAFCRRRCRHGHHGHDGHGDHDGHGGHGHDGDHDHSSDNESDSDHDGDHNHGHDHHHDHDHDGNHDHDGDHHHCPHWKEFIDSLLHYHILPGRWPLCRIRHSKTIPTSLHPPGLGFSSELSPKYHHHHPQRIRSFTTPFLQRTYLNFRTVLTPHTVTIHAKNGIIHLIDSLLIPPPNQTTALRLLPSHFSTLTLALETTGLASELADLPRSGGATFFAPDNHAWMRLGRRANAFLFSEHGKPYLKALVKYHVALNETLYSDAFYSGKKGHHDGNEMEAGFGFGYEHVDLTTLLHDLPLSVDIRRWHGWVTILVNGFTRVLIRDGVAADGVIHVIDQVLVPPCKHGGNGENLKSGEVSVEELKARLEPYVEDETRLSGAAMMDTCTQEALYMKKAGQKYVAAIGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0D9</accession>
    <name>G0S0D9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0009670</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691491.1">
        <property type="nucleotide sequence ID" value="XM_006691428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0D9"/>
    <dbReference type="STRING" id="759272.G0S0D9"/>
    <dbReference type="GeneID" id="18255005"/>
    <dbReference type="KEGG" id="cthr:CTHT_0009670"/>
    <dbReference type="eggNOG" id="KOG0615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003637_0_0_1"/>
    <dbReference type="OMA" id="PRRDNEY"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000470">
        <property type="entry name" value="Serine/threonine-protein kinase RAD53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FHA" evidence="12">
        <location>
            <begin position="110"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="289"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="605"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="777"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="919"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1241"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="605"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="690"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="919"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="9">
        <location>
            <position position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS23300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1261" mass="140812" checksum="F3AF0CF24BE3376D" modified="2011-10-19" version="1">MDLENSQATQENALDPRRLGGQNSGFSDEDISDIICLLLPYSEAARRQLRNIAATENANRIVERENVGQLDLDYALEEDMRDIARIQPVLGEHYIALRFSTPVKDPLQGFTFGRNPTLCDVCFRNDPRRRLSNVHFRIYLNEFGVLMLEDLSTNGTSVDEVLLKKKDSPARETKRTLQSGSKIQIFMHQDSMDLVFIVRIPIRHGACQEAYERNLQAYMAQRERLANETIVPGPGGRVDIFKPAAQKNGERNVNKVVARREQADGMPVKQPSRLRTEAIPRPWNGSNKYNRVCEIGRGAFATVYKVTLKLTGHPYAAKELDKRRFMKNGVLDQKVENEMKIMQKVKHPHIVNYIEHLDWDDRLLIIIMDFVGGGDLGKLIAEHGPLSEPATKIMARQLLDALGYLHSMNITHRDVKPDNILVQSFDPFVVKLTDFGLSKMVDNDQTFLRTFCGTLLYCAPEVYSEYAEYDNHGRRHPRNRRLRPATGPRYHNAVDVWSLGGVLFYALTKTPPFPARNGASHSELLHQIMTKPLNVEPLKQANISNEGIDFLKRMLNRRPENRATIPELLNHPWLEGVALPPIDQVADEELPANASQLSLEDNANETEGADDVELQVPSDDEINDEDDEEVVRQTDHEDEGESEKENQTLGPANGRQRRLFGEVNPSAVGSSGGIRAERLNLPVTAPSSESSRETEVLERPAEIKDSFESDSDSTPRQPTSRLPPGAGGSRRGSLRSINSNESRSVEELNNMTFDVASQSLGGAESILGNLNMKSRAASAAPSHSIGDVTSSKRKPPSDLGEEGEAQATESRRTLKRLRSQPAAPPAILDLPVAPGEYELLVQVPCIRNHSCRQIDNPVHKSTFWSARDRSTWHLNYPEMTQLQFDAFNMAAAARNEEFGPGKTPLWSLAVKYFPPTNRERVGDKSRVPRRPLDDLRLPPTAGRNGISDDVPDTQRCQDIRPPMPIFSEPGRPVIACLQSAAVSAIQGISVLITEAMISWGRAMSNTRSYIPRTEGKVPKNALKILLWKPGFDPVKNFRPWNRQGEDEESLYFYIATKATQGISINGVPLPSWNPKATDDACRYWMRLHDGDRITVWQTADGLTRTELIFWCGWGGSSKPRGSASVNRPCLVADDIAQQLDEVCYRAERKMRGLSEHDLKMEEANHDLEVRLAHIDAERQRSRDFEVRRQEACRALGVNPHRRHSPPVGVGLTICSAAAAAANGEGSSSVAGGYSSYNRTVPALRHTSPPTASDLLRAARGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G0S140</accession>
    <name>G0S140_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MICOS complex subunit mic19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0012250</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2022" name="Sci. Adv." volume="8" first="eabo4946" last="eabo4946">
            <title>Structural insights into crista junction formation by the Mic60-Mic19 complex.</title>
            <authorList>
                <person name="Bock-Bierbaum T."/>
                <person name="Funck K."/>
                <person name="Wollweber F."/>
                <person name="Lisicki E."/>
                <person name="von der Malsburg K."/>
                <person name="von der Malsburg A."/>
                <person name="Laborenz J."/>
                <person name="Noel J.K."/>
                <person name="Hessenberger M."/>
                <person name="Jungbluth S."/>
                <person name="Bernert C."/>
                <person name="Kunz S."/>
                <person name="Riedel D."/>
                <person name="Lilie H."/>
                <person name="Jakobs S."/>
                <person name="van der Laan M."/>
                <person name="Daumke O."/>
            </authorList>
            <dbReference type="PubMed" id="36044574"/>
            <dbReference type="DOI" id="10.1126/sciadv.abo4946"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) OF 116-164</scope>
        <scope>DISULFIDE BONDS</scope>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691742.1">
        <property type="nucleotide sequence ID" value="XM_006691679.1"/>
    </dbReference>
    <dbReference type="PDB" id="7PV0">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.15 A"/>
        <property type="chains" value="A/B/C/D/E/F=116-164"/>
    </dbReference>
    <dbReference type="PDB" id="7PV1">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.50 A"/>
        <property type="chains" value="A/B/C/D=116-164"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S140"/>
    <dbReference type="SMR" id="G0S140"/>
    <dbReference type="STRING" id="759272.G0S140"/>
    <dbReference type="GeneID" id="18255263"/>
    <dbReference type="KEGG" id="cthr:CTHT_0012250"/>
    <dbReference type="eggNOG" id="ENOG502SDJV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093897_2_0_1"/>
    <dbReference type="OMA" id="GKSLNCW"/>
    <dbReference type="OrthoDB" id="5544375at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012471">
        <property type="entry name" value="DUF1690"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07956">
        <property type="entry name" value="DUF1690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4 5" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4 5">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="7PV0"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="7PV1"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="19264" checksum="993B029D2E37F512" modified="2011-10-19" version="1">MGSSSSKPSNPAPHVWKGTPQPGVSQNLVEQLETSNETDISRQQAAELLVQQRVAAELKRLREQEIEALREVQQRLSAEPDLAEDQQQHQTSITRQQVAKQIDDLRSKLEERRQVRPLPESVEKARSEVVRCLREHDRRPLNCWQEVEAFKEEVRKLEKGWVDKVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1E4</accession>
    <name>G0S1E4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0013300</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691846.1">
        <property type="nucleotide sequence ID" value="XM_006691783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1E4"/>
    <dbReference type="GeneID" id="18255368"/>
    <dbReference type="KEGG" id="cthr:CTHT_0013300"/>
    <dbReference type="eggNOG" id="KOG3043">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054590_0_0_1"/>
    <dbReference type="OMA" id="PTEWYPP"/>
    <dbReference type="OrthoDB" id="2147163at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668:SF1">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668">
        <property type="entry name" value="DIENELACTONE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G01940)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="124"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="347" mass="37918" checksum="955FF6ABA684A847" modified="2011-10-19" version="1">MVVNQLRAAAGRSVAAYPAPQGPAAYAAGSQYARRVSIPSSIHRAVFAPAPSHPFASSTCLSSVHRLVHSSSVSSRTLGSQSQTAKMSTMPATCGHNEACCNIPPVVWQGYSPKGAYDEVDGLKTYVTGPEDATKGIVLIYDIFGYFDQTVQGADILATSHAQKYRVFIPDWFKGEPCPIEWYPPNTPEKQRDLTAFFQKNPPQGVAAKLPEFVKALEAKYPNIKSWGVLGFCWGGKVVSLVTSGDANPFKVGAQCHPAMVDPSEAKTIKVPLVLLASKEEPDDKVKEFEDNLKVAAKHVETFKDQIHGWMAARADLSDPRVREEYARGYRVVLDFFAKNWDASPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1J9</accession>
    <name>G0S1J9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Dicer-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0013870</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the helicase family. Dicer subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691901.1">
        <property type="nucleotide sequence ID" value="XM_006691838.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S1J9"/>
    <dbReference type="GeneID" id="18255425"/>
    <dbReference type="KEGG" id="cthr:CTHT_0013870"/>
    <dbReference type="eggNOG" id="KOG0701">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000907_4_6_1"/>
    <dbReference type="OMA" id="CCVNLIR"/>
    <dbReference type="OrthoDB" id="416741at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050688">
        <property type="term" value="P:regulation of defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18034">
        <property type="entry name" value="DEXHc_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd18802">
        <property type="entry name" value="SF2_C_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.380">
        <property type="entry name" value="Dicer dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038248">
        <property type="entry name" value="Dicer_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005034">
        <property type="entry name" value="Dicer_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF37">
        <property type="entry name" value="ENDORIBONUCLEASE DICER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03368">
        <property type="entry name" value="Dicer_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51327">
        <property type="entry name" value="DICER_DSRBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="1" id="KW-0930">Antiviral protein</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="205"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="563"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="Dicer dsRNA-binding fold" evidence="13">
        <location>
            <begin position="774"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="10">
        <location>
            <begin position="1131"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="10">
        <location>
            <begin position="1323"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="10">
        <location>
            <begin position="1507"/>
            <end position="1528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="22"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="136"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1425"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1428"/>
            <end position="1438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS22909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1660" mass="185708" checksum="3134F7D6020546D0" modified="2011-10-19" version="1">MPSRLEPGTIANVTKCMSRSKLTKPELRLGSGLSLSRSSRLAHTNRGARHSAASASSSSCELHHVLTQDRTKSRTGDVRGIPNSTSLLSDPPGAPIASQEPNFKSFHAQPQPYGRRITRPAPTMTSYMPLRSLSQTRAMSATTTDDELSCSSSASDSEAVSAQLSREVETADAVPREDSPSRMSVTASPPSPPPPITPRAYQLEMLEESLKQNVIVAMDTGSGKTQVAILRIQYELERSDKVVWFLAPTVPLCHQQHVVIQTQLPAVTTRLICGDDDIETWSAIPGVWDGVLKHTRVIVSTYQILFDAVAHALVPLSALSLIVIDEAHHCIKMNPVSRVMKEHYAPLKAKGAQVPAVLGLTASPVMRTNPADLEKLEQTLFAVCKTPSRHRAELMQMVTKPDLVTVTYPGDPQGQVPEPPVLGRLIAAYRGMQLAQDPYIQHLVMDGSQRSRAKLQKVVSKRKTRSMEHMYALCIRTKDMLQRLGPWAAEYYIHEVISAFFDDPEASTGPLDEEEVELYNPIFEYNLQVQERRYISSILSQVNAQPPATTDQGPSPLSPKILALLDVLESFAKDDPSRKPVGIIFVRERATAAVLSHILSIHPRTAPHYRVACMVGGTTRVPGSGGGSRSNKRREYIDLIKKGKDDGLEALQAFRQGEVNLVVATSVLEEGIDVPACNLVVCFDVPENLKSFIQRRGRARMGVSKLVLMVPEGEQAKGWDEREREMKEMYEDDMRVVRIVEEIENGIVVETEKEDEYPVLRDPETGAQVTLHDAKAHLEHFCGTLRSSTSAFTELRPFYILHGEHGQSVNTFAPVPLRATVHLPVVLPPELRRIEGIRSWLSEADACRDAAFQAYQKLYEAGLVGKHLLPIREESVFGELESRDGLANVKDVMDPWVAVAQAWRQSKKLWKRGMTLTRVRDGEQIRWEVVLPVEVPRMEKFFMFYDKETSWEVTMDQDQEAIDRPEDTQTEPDDTPALLSLAFSHRFRILGKGEYVLRLLCPSLPSSLTFQGRVTERLLKRHPDHLLRWVHDRNYPFGDHTFLPPREPENEPQVGMRKVLPHKAGFFRKNSAPDAMPVSMGQNGEPKFDRIVPLREVVMDAVPAKYAEAALMIPALLVVLGDHLLARDLLTERLREKTGMGGDDLGNVVRALWASGAQRPGDYENMEFLGDALLKFLTTVNCEAKYLTYPEGFLSPIKDRIVSNMRFFRAAVGFGLDRYIIDAKMVQKRWRPPTISSILGRPPSVTAPRQLSTKTVADVVEALVGAAYLSGGTDRALTCVPLFLPDVPIDWLPVGRCRDILFNHAAADDPLPKTMRRIEEQLLGYEFKKKSLLVEALTHSSCPAGPGVRGSLDRLELLGDALLDFLVATKLYELYKCNVDGQQQMVVPYILHIMKSALVNQDIMAVLILEEWTILQEELDIIAPPSPSSSQGSETAISEGNGEHSGGVTLRTRHVRVPLTAFLRHNTIQLSRFMNDTTRRYAAMRHEVQHALTHGDRYPWRLISQLRAPKVFSDVFEAVLAAVWVDSGDMDVCRRVLERVGLDRLMKRIVELGPMGVLHPREELNVLTSKMRTLGRSVGYEVFECEREEGSEGEESVMEEGKKKDKDSKRRFGCRYLVDGTVIAEVRGTRSKDEARTWVAEEACRILRREPYWLSVEEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G0S275</accession>
    <name>G0S275_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tyrosine-protein phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0016240</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692127.1">
        <property type="nucleotide sequence ID" value="XM_006692064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S275"/>
    <dbReference type="STRING" id="759272.G0S275"/>
    <dbReference type="GeneID" id="18255662"/>
    <dbReference type="KEGG" id="cthr:CTHT_0016240"/>
    <dbReference type="eggNOG" id="KOG0789">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0791">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001645_9_12_1"/>
    <dbReference type="OMA" id="VWRMVVE"/>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF449">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="201"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="455"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="350"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="515"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="587"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="372"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="587"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="600"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="623"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS22108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="640" mass="69918" checksum="D575494DAFEB0F23" modified="2011-10-19" version="1">MAHVPRWPRRKKDVAPPTLITTDLSGNNNNSSPSSNKLAAAVAAPAESQPAAAPAPVPSPGQVRSSLHKLKGVFHRSAKRARDSPPASLPHSPAAAPVSVATGNGNGNSNGGNSNGNLNVNVSEIRPVSPLSLKTDAASTMEKATKTPKMPAFLDLPKQEIENRFSEIVWRERHRMMQSLTNPSPDFRWARVTGPHLKLLDRYVNIQPWNNNRVKLRVPEGKLDYINASPIILHPRAARDGSTKEPSRYIAMQGPKQITTDHVWRMVVEQLESPGVIVMLTETHEGAIEKCYPYFPRSPDDPPLEVNERDEFGDGFRATVKCEAIEETPAGDAIELRKLVITVHPKREIPLEGIDGDDDVKMKSPQALQERSASSTPSSATPITTSSATTPINPSTPALPTANLISAPISQPATPQEPTPRTAFDSSAPVDQRIVYHFLYKKWPDFGVPSLSDLDSFFTLMRLSREKNSSPSNPRIVHCSAGVGRSGTFIALEYLMGELERGILEGWDDRVEELKQRDRSGNQQGDGEGAGGMQSALPPDYAREDLVFEVVDALREQRRTMVQAEAQYEFIYRVLRKFWVEKYGPPEEEEIDGQDESTGDGKGNAGGSGGCGGCGDEEQMEGEGARDGEPAAKRLVVDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2C1</accession>
    <name>G0S2C1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol-4-phosphate 5-kinase</fullName>
            <ecNumber evidence="2">2.7.1.68</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1-phosphatidylinositol 4-phosphate kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Diphosphoinositide kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">PIP5K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0016710</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14425"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.68"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.1.68" evidence="2"/>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692173.1">
        <property type="nucleotide sequence ID" value="XM_006692110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2C1"/>
    <dbReference type="STRING" id="759272.G0S2C1"/>
    <dbReference type="GeneID" id="18255709"/>
    <dbReference type="KEGG" id="cthr:CTHT_0016710"/>
    <dbReference type="eggNOG" id="KOG0229">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004312_0_3_1"/>
    <dbReference type="OMA" id="DENHANW"/>
    <dbReference type="OrthoDB" id="20783at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17303">
        <property type="entry name" value="PIPKc_PIP5K_yeast_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.800.10:FF:000009">
        <property type="entry name" value="Phosphatidylinositol 4-phosphate 5-kinase its3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="13">
        <location>
            <begin position="329"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="31"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="128"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="750"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="282"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="750"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="784"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="814"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="843"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="919"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00078403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS22154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="956" mass="106617" checksum="83F62F114FD03F0F" modified="2011-10-19" version="1">MPAFVQDTLSTIDSQSSGVVHLDSPARFGLDEGKLSLNGPNARQPHSHTSHESFGESSTNSTKSTNTSRTSVELERRPTDDCLHLPSMIPQPNGCVQGGEDEVVNGARVNGASSQLLGKSMHTLVDRTIPRLATKGKENGLSMEHERHDLSSDSKPDQPQQPETKADSRPVENETAPAETPSTSRLEAPSSAQVQNLQKTSPHRYSSPPIYEPGPSSTSTLQSAPTPGIRQRHTLEVPKVSQSRSSRDSADAAYASGRFSPTIPPAPRRASLSLGRRNTRSLHSEGPRDEIIPDEDAMRWAEALRQKRASKRRRRELEDDDRVLVGTKVDESHANWVTAYNMLTGIRVAVSRTNAKVDRPLTDEDFEVKQKSTFDIAGNELVPSAKYDFKFKDYAPWVFRHLRALFRLDPADYLMSLTGKYILSELGSPGKSGSFFYFSRDYKYIIKTIHHAEHKFLRKILRDYYQHVKENPNTLLSQFYGLHRVKMPYGKKIHFVVMNNLFPPHRDIHQTFDLKGSTVGREYKEEDLENNPRATLKDINWMRRKRTLELGIQKKKLFLEQLHKDVRLLQRLQIMDYSLLIGIHDLQRGNEENLRDKTLRVFNPGGNSAEDNDPNAVLMRTPSKLENQRKARELRQMIQSEKPVPMNETDSRMPDELDEGHSRPGFIFNQDDGGFRATHEDNSPADEIYYLGVIDCLTHYGIVKKLEHFWKGLSSDRSQISALPPYEYGERFINFIEKVTMSREEAARLAQQQEEQQAAEAAAKERQRTASWGSLGRKSSSNIPPAPSYHPPPPPPPPPPASGQTDATPDRTARTVSSTPTITVSGREPTILPVVEEAAEGPSTGNPSQQGDSRPSTSAKDGDDRPRGFGFSLSRLRSKSRPPPTPPKNDASNGLLAKPESADSGYAEGNNGSGSEGPARSEKSLKMHDYSGNDGLGKALPPLPHQDTPARMQNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2P8</accession>
    <name>G0S2P8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0018020</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692300.1">
        <property type="nucleotide sequence ID" value="XM_006692237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2P8"/>
    <dbReference type="GeneID" id="18255840"/>
    <dbReference type="KEGG" id="cthr:CTHT_0018020"/>
    <dbReference type="HOGENOM" id="CLU_000288_34_10_1"/>
    <dbReference type="OMA" id="DECDNAD"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="13"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="139" mass="16079" checksum="712D221A6C666278" modified="2011-10-19" version="1">MDAYIRYEKYRSQPSLNDLEDMFQAIAPLYKDGVYVIVDALDECQVSNSIRSKFIKTLLRLQSREINLNILATSRSLPDIEQAFYGHSRLKIIAQREDIERYLRNRMSDLCSAAKRSELQNEVIIRIADAADGMYVTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0S311</accession>
    <name>G0S311_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RlpA-like protein double-psi beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0019250</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692413.1">
        <property type="nucleotide sequence ID" value="XM_006692350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S311"/>
    <dbReference type="STRING" id="759272.G0S311"/>
    <dbReference type="GeneID" id="18255963"/>
    <dbReference type="KEGG" id="cthr:CTHT_0019250"/>
    <dbReference type="eggNOG" id="ENOG502S6X4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1261374_0_0_1"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF27">
        <property type="entry name" value="RLPA-LIKE PROTEIN DOUBLE-PSI BETA-BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408786" description="RlpA-like protein double-psi beta-barrel domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="RlpA-like protein double-psi beta-barrel" evidence="3">
        <location>
            <begin position="63"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS22394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="219" mass="22966" checksum="7787C5500FC5B0B9" modified="2011-10-19" version="1">MFSKSLNTIAILAAAIANLSNASPVKEGVEANTGPRMAAAISSANIDALNNIGTINLTRRSNDGSFTWYNTGLGACGQVHTDADLVVALSAPLFDPYTPNSNPNYNSLCNRRLRANYNGRSVDATVVDRCLACATYDLDLSPAAFQQLADLSHLYAAAEPTPAKLTYLFSANLTIAEPVSIGSVPYDTGVLLIIIGGNFSGPVLKGNHEIPAPTQHVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0S327</accession>
    <name>G0S327_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0019430</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692429.1">
        <property type="nucleotide sequence ID" value="XM_006692366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S327"/>
    <dbReference type="GeneID" id="18255981"/>
    <dbReference type="KEGG" id="cthr:CTHT_0019430"/>
    <dbReference type="HOGENOM" id="CLU_450536_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="606" mass="64590" checksum="16D20521FF13C56A" modified="2011-10-19" version="1">MEGAQYPASSTEPPGLDLPAGEERIYHWQGEETHLPTAPAPRKREEMANECAKLHDKILQTARMEEDGLEYIHCPLIDFKRFFELYTHIHLYNNMEATVSATNPTPNQLLEFAASVPSGQSSLPSQHPLLPPLTVAPSELTPAKRSRGRPPKNKAQVLGPTQGLDQRLAAASAAVSGRPFPPVPTYDEPVAGAQPQPTTAVSTSITPDLLQPPAGQPAALQALTDFQNEKYLSFWQMGYEAAFRPAFEEGRRAAAPIAYAVHLNGLRDIRPRLETVKGYVKFGMGRHADGYKASKKKYATTARNLDPASIAKSANSALRVGQTIAGIGKALALAQSSATQTSTPTPIIGQPTTNQGASALFSQPSISAPTIGQILGNQSMTPAPGNNNSVLAAPNASLTTPTENPGSTSNTTTAVFVPLPTTTSNNNSQGSQLTNAPNNPTRNVTPAQTQSQTLSECTSTQNPPAEPPLTPSQQRLQALRNALVELDIISTGMDNLIARTERASNTTLPIDFDSLMRIAFEGEDSFEAELMKVVGADPIGKAKVRHEMKKLLGKSVMKEHGQGMQAAQAALDESDVSLGQEVESVQNGQGLLGAQTVQGHQTFQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G0S373</accession>
    <name>G0S373_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7143 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0019940</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692475.1">
        <property type="nucleotide sequence ID" value="XM_006692412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S373"/>
    <dbReference type="GeneID" id="18256032"/>
    <dbReference type="KEGG" id="cthr:CTHT_0019940"/>
    <dbReference type="eggNOG" id="ENOG502S5W9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120582_0_0_1"/>
    <dbReference type="OMA" id="RQNPCFI"/>
    <dbReference type="OrthoDB" id="2497581at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055567">
        <property type="entry name" value="DUF7143"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37592">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37592:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23631">
        <property type="entry name" value="DUF7143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408854" description="DUF7143 domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7143" evidence="2">
        <location>
            <begin position="26"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="185" mass="20044" checksum="6F8EF9EA11019E35" modified="2011-10-19" version="1">MKFLTFLTLGVGFAAAERQNPSACFIIGNQQLPKETADITNQIKDRISCNPRRTTLSGVPDVSSGGITFSSINFATSSQTPLQFALSRFATPTPLRNADLATFQKQLDVYLATEAGIRSVGGNLAIKLPKFFLQFQVSRIQTAQGNPPTAPGLQVNHLLEKVLKNAPRESEELKNQVGALARILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3D9</accession>
    <name>G0S3D9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha-amylase</fullName>
            <ecNumber evidence="4">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CTHT_0020660</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692541.1">
        <property type="nucleotide sequence ID" value="XM_006692478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3D9"/>
    <dbReference type="SMR" id="G0S3D9"/>
    <dbReference type="STRING" id="759272.G0S3D9"/>
    <dbReference type="GeneID" id="18256104"/>
    <dbReference type="KEGG" id="cthr:CTHT_0020660"/>
    <dbReference type="eggNOG" id="KOG0471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006462_7_2_1"/>
    <dbReference type="OMA" id="HGYWIAD"/>
    <dbReference type="OrthoDB" id="204980at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11319">
        <property type="entry name" value="AmyAc_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000120">
        <property type="entry name" value="Alpha-amylase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013777">
        <property type="entry name" value="A-amylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015340">
        <property type="entry name" value="A_amylase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF208">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09260">
        <property type="entry name" value="A_amylase_dom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001024">
        <property type="entry name" value="Alph-amyl_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408793" description="alpha-amylase" evidence="17">
        <location>
            <begin position="26"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="509"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="18">
        <location>
            <begin position="35"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="13">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="52"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="263"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="462"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGS22522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="533" mass="59605" checksum="87F1C90FD372B758" modified="2011-10-19" version="1">MRSSLFGAAAAAVLSFVGLTAAADAEEWKTRSVYQVMIDRFARTDGSTDHECEYFRFCGGTWRGLINKLDYIQDMGFTAIQISPIVKNIDEHTAVGDAYHGYWSLDNYALNPKFGTEKDFRDLVDEVHKRGMLLMVDVVVNNMAQAFDNKVPPKIDYSKFNPFNDQKYFHDYCNVTRWEDPENYQNCWLYPYGVALADLKTESDEVVKEFQNWIKQLVANYSIDGLRIDAAKHVNDEFLPQFVEASGVFAWGEVLTGVTNDLCRYQTKGLLPGMPNYLEYYPLLQAFNGGSMEEVAKYRNEAASGCNDTSVLGSFIENHDMPRFAMYNEDMAIAKNAMTYTFLNDGIPTVYQGQEQHFKGNGTPYNREPLWISKYDKSAPLYQLTSTLNKVRNNAIKLSKDYVNTPAETLFNDVNHLCLRKGPYGSQVVFCINNQSSKGPKYELNISGGFHPGDKVVEVTRCRHTTADATGTITMYMGNGEPRVYVHADAIKGTGICSDTKEDGPVGNAASGVGSTAGIMIAALASWAVFFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>G0S427</accession>
    <name>G0S427_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0022320</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692699.1">
        <property type="nucleotide sequence ID" value="XM_006692636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S427"/>
    <dbReference type="GeneID" id="18256270"/>
    <dbReference type="KEGG" id="cthr:CTHT_0022320"/>
    <dbReference type="HOGENOM" id="CLU_1120057_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="248" mass="27609" checksum="1C935C800D4D1A17" modified="2011-10-19" version="1">MTAWRMGVEERHSGCPRSSARSQDSSSNWSKDLLVDTITSKSSSLSAKKSHHELNGSNPRFPNAELNPPLFQTLRRQDAHHYHGSTSSLQRDHRISSRQPGVAEKEEGEGLDNKLVATSSSLIFAFSSSSTTPSFSYSSPTALVGSPEPEPEPEPTEESTESFLSASLTPEQIWSLSNILPPEVMDRLLELLYPDSDEEDAAGVRGMHFEEWLAKLRELLEPYLEVVGELERALNPASYVYVGKRRHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0S429</accession>
    <name>G0S429_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative sequence-specific DNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0022340</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692701.1">
        <property type="nucleotide sequence ID" value="XM_006692638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S429"/>
    <dbReference type="STRING" id="759272.G0S429"/>
    <dbReference type="GeneID" id="18256272"/>
    <dbReference type="KEGG" id="cthr:CTHT_0022340"/>
    <dbReference type="eggNOG" id="ENOG502S1NM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035241_2_0_1"/>
    <dbReference type="OMA" id="RFISHAH"/>
    <dbReference type="OrthoDB" id="2285533at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF9">
        <property type="entry name" value="MEAB PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="5">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="150"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="92"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="16"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="209"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="317"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS20405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="405" mass="43071" checksum="67946A594619B09C" modified="2011-10-19" version="1">MSVDKKSPPKEESEESMGSSPEGEAPAQPPASAAPAASSTPAASNDNNASGAGVSAQQPENQQPKRKGGRKPIYATSEERKQRNRQAQAAFRERRTEYIKQLEEAIRTHEQNLANLQAAHRHAADECLMLRYKNSLLERIDVQAELRAKTGSPNLGPTHIPQPTIVQPPPIQRPIINRHHPRRSNSGIAPKIEPGINVTPLPPPLQPHSALSPTNRPTPSSHSASPPGTASFGSQHAPSPAGSDHLNPSMRPTPPSGPVMKATPPQMGPPVHGLPTPRSMHQPIGGLQHSVNNQPRPSEYDAAADMIDDTADTPDTPSGPGPYPGPPYPGDPQPMSLSSPVTTGPPGSQPMAGQSPMDSSVAHGQHGTYPSMTQLLDTSYDFDPFGLSASMAFPTQFSFDTSNMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0S449</accession>
    <name>G0S449_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0030700</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693519.1">
        <property type="nucleotide sequence ID" value="XM_006693456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S449"/>
    <dbReference type="GeneID" id="18257108"/>
    <dbReference type="KEGG" id="cthr:CTHT_0030700"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="OMA" id="TWTMDNR"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF27">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G15730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="530"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="127"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS21223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="587" mass="65043" checksum="574A717FC7D409C8" modified="2011-10-19" version="1">MRAKTGTTAQEDHNRPTSGSSYEGSGYSHVDDNDRLEPPTHPSTSTSASSPLLQDGEWTDGEQYTPQMISDVEDDEYKSDDDEEAGRVAARRLTPGRQPPAPRWRSPRKWFTQEEEQAVVRKFDRKLVVFVAGLYLLAFLDRSNIGNARIAGMDDDLQSSPPREDWYEWSLTAFYLAYIGFEWMAVLWRIIPAHVYVALIVFLWGLAASLQAVAVNYPMLIALRTLLGIGEAGFTGVPFYLSFFFKREELAFRTAIFVSAAPLATSFASSLAWLILKAAEHSPIAPWRLLFLVEGFPSVLAAALAWNIIPDFPQTASYLTQREKKIARHRLQLERPLSRPRYSSRSKSSSPIFDSLSALLDPAAWLTSLILFLVNLAYSSLPVFLPTILQAMGHSALTSQALAAPPYLVAFIAVLLTAHASDKVGARSPFLIAHALFSAAGYTILALSDTKLLGHIPPDSWIRYFAVYPAAIGFFSVVVLTVSWSVNNTTNHASSSGQRRGAAAFALLQAVGQCGPLLGTRLYPDRQAPYYTMGMAVCAVAMVGVAVLAGLGRWYLKRVNRRWDEEEESEQGEALSRRVVGRFRYML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0S499</accession>
    <name>G0S499_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Galectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0039420</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS22057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694353.1">
        <property type="nucleotide sequence ID" value="XM_006694290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S499"/>
    <dbReference type="SMR" id="G0S499"/>
    <dbReference type="GeneID" id="18257980"/>
    <dbReference type="KEGG" id="cthr:CTHT_0039420"/>
    <dbReference type="eggNOG" id="ENOG502SYUU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1927358_0_0_1"/>
    <dbReference type="OMA" id="HLYNKRF"/>
    <dbReference type="OrthoDB" id="167809at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Galectin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="131" mass="14613" checksum="90894DB05277E187" modified="2011-10-19" version="1">MVLQIVKVNPTATKLATPVQKDAIAIIRLSAQPGSENAIVFNSKTKNGQWQKEERITFAGRFTRRDPRIEVEDLGNGYQIKIDGATVHLYNKRFPTPVTGLFYLVEPDNIPLFGDTLAVEVHPNSNSLGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4S6</accession>
    <name>G0S4S6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0023370</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692801.1">
        <property type="nucleotide sequence ID" value="XM_006692738.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S4S6"/>
    <dbReference type="GeneID" id="18256375"/>
    <dbReference type="KEGG" id="cthr:CTHT_0023370"/>
    <dbReference type="eggNOG" id="KOG4299">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001648_0_0_1"/>
    <dbReference type="OMA" id="CYYFVPP"/>
    <dbReference type="OrthoDB" id="5876363at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15535">
        <property type="entry name" value="PHD1_Rco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15534">
        <property type="entry name" value="PHD2_PHF12_Rco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052819">
        <property type="entry name" value="Chromatin_regulatory_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47636">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47636:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="985"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="151"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="348"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1371"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="202"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="248"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="411"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="436"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="466"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="542"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="613"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="657"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="672"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="715"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="775"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="791"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="877"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="905"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="936"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1371"/>
            <end position="1384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS20505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1500" mass="161319" checksum="C7462C07EB57F97B" modified="2011-10-19" version="1">MLTLCAGARSASVGSKKGASTGEQAAAAPATPVSMSSTPVSSNTRATRSRFSSPQTASGNAATDSSSSRTERLSASHAAKGGNEKEKEFMQRWLEPPVQIKASFQDAGLVRHGIFETMAPLGTLPKVGLFKKTALPPAPAPEHAPTRKIIVKQRTQQPPAPPVPATAPEADETEEENDANTEEDVETQGGASLEFEEEPVHTASQAMSKTRTVLPTASRSRSRRPLGSRDSDDEEWAPAPGRASQKSATGRFASRTGTARAAAASAGHQQASSANSRAMMEEKQFVDKVVEAAVDEALSHNRYPTAWALRTLYYENSSRSDFVNMLAKVFTQTADVDTLQEFKRLMEPRKREGKKDNKAYNYFVPPSPSKKDPKPQPPKRSPYGDLIKLDLSALRRRNREGVRAASKNKKEKQEKEKQEKERAPKEPKEPKEPKGRPASAPPSSRQQPEPEPAPVPAPATTRKRERSQDKKTQQQQQPKDRTDESASAPEPEPEPEPEPEPEPEPEPEPEPEPEPEKQEQDEADPDPDPGPEPPRKRRKTVAAAKQQQPQQQQAQQKKAEQLSLQSPKSKQSQRQQQQSDATAKMVTSSSNGVNGKAAAKVETPSRRSRRARSLSTSSSLSSARSMSPPDSIQERSSESNENTELAVDAAEDTGEPQAEQAEQAEQAEQAEKQPSSRTSPVLRQPITAKRRQKQQRSSAPPRKSARNVSHLSRHASPQTDPAAAADADVSSATANAPEEQPYEMPAVVDTPSLPAKKGSAKQGAPWPVVFAPKVGKLDENDTKLKLRQNARRVTQNSNELASISNVRASSPEGASRQGLDSEADSSTATPMPAPTGRITRNGLANASASRPTPVPLREGRSTRSSLKRAAEEMEDQPSPTTANMPGSEAASTAANSRAGTPALRSSKRPRTGLRVKTSPVKKKNGTSAGIPRASGERSSPIGNGTANREGIWSPRSLNPSHFLIGYPSPITKRAHSSGVAKDDNDDYCSSCGGNGELVCCDGCTRSFHFNCVDPIIRQDDMPVEWFCNVCRASRSTAPAQHYSGAFALLLEKLDSKNSSAFRLPASVREYFEGVRTGVDGEYEEIVAVTKPPRRRKDDEQPPDFYRLCDAQGNPAICHGCGKGSGNVRPIIPCSVCAVFWHLDCLDPPMTQPPPLRNWKCPLHVEELLAKVPGVLAPAHRLRKPKQLPPVVRPAFSRGFINDGYIEVDLEETENLSGWRNLETYGRTVRLPERGIKLDFLSRALESRMQKETVIQTSQAATAVTSAGTNAESASAPAPLGTRSLEEQQAALNLVWLSTNGNNQPPADGVRTLIDVMISEAEPTVIDMMARANPGRLGELTSLNHMDQQALRAMLAQAEMMVERIRSLLQPAPSAAPTASSVPALRSPTAAEPTEKSPARAVSVAAISPAPTSSSDEEVPPMTQGEKTPVLPGGTSPAPVAEEDGVEEPGPATPPSKTGDESNSNGGAKTVVEDGGPVVAVAGEDGAKEGFVGEDGQVELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4X0</accession>
    <name>G0S4X0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0031960</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693637.1">
        <property type="nucleotide sequence ID" value="XM_006693574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4X0"/>
    <dbReference type="GeneID" id="18257234"/>
    <dbReference type="KEGG" id="cthr:CTHT_0031960"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_533157_0_0_1"/>
    <dbReference type="OMA" id="PLEWAAH"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="193"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="250"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="295"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="472"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS21341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="529" mass="57503" checksum="8A28DDE84C7399E3" modified="2011-10-19" version="1">MASHTLNALPMELIVFIVENLDNVADIAALAQTNRRLYSTAHPLLYKRAAQCGDARPLAWAARHGLMSTLKMALDAGIDPNHEFVERISADDWERACVVAQENVVKNRGGELWDPVTRKPCESIPPTLPRTGGAAEIDEIAKPIRTSETAQLPATPSVTSQPSFTPFSRSFTFRPSLAPQPVKSTSSPNLVTRRYRALHVAASRGYNDILLKLLDAGASTNVPSERFCSCAPAYGLLNALENPEDDRDPPSWSPLHIAICHSHEETAQLLLEHGASHMMEHFNMTNANDPDNLGYGSTALHHAAGMGLTKLVDYLVTSKIQTNIDPRDDRTLTPFYHAYAQRRWDTTIPQLLSLGASVEVEIKMYIPYSAITPFGEACRLGHFAVADQLLKLGANPKHGFVTTTVKGGCLTPLHMCCMQSAVPVGTAPPTAAAEEGVGEREGEEDEEREMARMRIIEKLISLGADINARDCFGNTPLMAAMQWKNRAAIKALIKAGADLKDCATEGREALIQEIKASLKNSVATASSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G0S504</accession>
    <name>G0S504_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0023620</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Dispensable for SPC enzymatic activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692825.1">
        <property type="nucleotide sequence ID" value="XM_006692762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S504"/>
    <dbReference type="STRING" id="759272.G0S504"/>
    <dbReference type="GeneID" id="18256400"/>
    <dbReference type="KEGG" id="cthr:CTHT_0023620"/>
    <dbReference type="eggNOG" id="KOG4112">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134505_2_0_1"/>
    <dbReference type="OMA" id="IHLTLWT"/>
    <dbReference type="OrthoDB" id="263893at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009542">
        <property type="entry name" value="Spc1/SPCS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 12 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06645">
        <property type="entry name" value="SPC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS20529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="102" mass="11239" checksum="EA913ED1A72AEFA6" modified="2011-10-19" version="1">MADQLLDQLRDVVEGKIDFEGQKLAERIVNFALSLVGAIAFLAGWLLQDIKLAVYLGLVGTAAVFLIVVPPWPFFNKNPINWLPVAVVAPPVNLVIDEKMLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0S590</accession>
    <name>G0S590_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vps72/YL1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0032670</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2018" name="Nature" volume="556" first="386" last="390">
            <title>Structural basis for ATP-dependent chromatin remodelling by the INO80 complex.</title>
            <authorList>
                <person name="Eustermann S."/>
                <person name="Schall K."/>
                <person name="Kostrewa D."/>
                <person name="Lakomek K."/>
                <person name="Strauss M."/>
                <person name="Moldt M."/>
                <person name="Hopfner K.P."/>
            </authorList>
            <dbReference type="PubMed" id="29643509"/>
            <dbReference type="DOI" id="10.1038/s41586-018-0029-y"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.75 ANGSTROMS)</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="journal article" date="2022" name="Sci. Adv." volume="8" first="eadd3189" last="eadd3189">
            <title>Structural mechanism of extranucleosomal DNA readout by the INO80 complex.</title>
            <authorList>
                <person name="Kunert F."/>
                <person name="Metzner F.J."/>
                <person name="Jung J."/>
                <person name="Hopfler M."/>
                <person name="Woike S."/>
                <person name="Schall K."/>
                <person name="Kostrewa D."/>
                <person name="Moldt M."/>
                <person name="Chen J.X."/>
                <person name="Bantele S."/>
                <person name="Pfander B."/>
                <person name="Eustermann S."/>
                <person name="Hopfner K.P."/>
            </authorList>
            <dbReference type="PubMed" id="36490333"/>
            <dbReference type="DOI" id="10.1126/sciadv.add3189"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (4.68 ANGSTROMS)</scope>
    </reference>
    <reference evidence="12 13 14" key="4">
        <citation type="journal article" date="2023" name="Science" volume="381" first="313" last="319">
            <title>Hexasome-INO80 complex reveals structural basis of noncanonical nucleosome remodeling.</title>
            <authorList>
                <person name="Zhang M."/>
                <person name="Jungblut A."/>
                <person name="Kunert F."/>
                <person name="Hauptmann L."/>
                <person name="Hoffmann T."/>
                <person name="Kolesnikova O."/>
                <person name="Metzner F."/>
                <person name="Moldt M."/>
                <person name="Weis F."/>
                <person name="DiMaio F."/>
                <person name="Hopfner K.P."/>
                <person name="Eustermann S."/>
            </authorList>
            <dbReference type="PubMed" id="37384673"/>
            <dbReference type="DOI" id="10.1126/science.adf6287"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693705.1">
        <property type="nucleotide sequence ID" value="XM_006693642.1"/>
    </dbReference>
    <dbReference type="PDB" id="6FHS">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.75 A"/>
        <property type="chains" value="I=1-219"/>
    </dbReference>
    <dbReference type="PDB" id="6FML">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.34 A"/>
        <property type="chains" value="I=1-219"/>
    </dbReference>
    <dbReference type="PDB" id="8AV6">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.68 A"/>
        <property type="chains" value="I=1-219"/>
    </dbReference>
    <dbReference type="PDB" id="8OO7">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="I=1-219"/>
    </dbReference>
    <dbReference type="PDB" id="8OOC">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.93 A"/>
        <property type="chains" value="I=1-219"/>
    </dbReference>
    <dbReference type="PDB" id="8OOF">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="I=1-219"/>
    </dbReference>
    <dbReference type="PDB" id="8OOP">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="I=1-219"/>
    </dbReference>
    <dbReference type="PDB" id="8OOR">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.87 A"/>
        <property type="chains" value="I=1-219"/>
    </dbReference>
    <dbReference type="PDB" id="8OOT">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.85 A"/>
        <property type="chains" value="I=1-219"/>
    </dbReference>
    <dbReference type="PDBsum" id="6FHS"/>
    <dbReference type="PDBsum" id="6FML"/>
    <dbReference type="AlphaFoldDB" id="G0S590"/>
    <dbReference type="EMDB" id="EMD-17006"/>
    <dbReference type="EMDB" id="EMD-17010"/>
    <dbReference type="EMDB" id="EMD-17012"/>
    <dbReference type="EMDB" id="EMD-17025"/>
    <dbReference type="EMDB" id="EMD-17026"/>
    <dbReference type="EMDB" id="EMD-17028"/>
    <dbReference type="EMDB" id="EMD-4264"/>
    <dbReference type="EMDB" id="EMD-4277"/>
    <dbReference type="SMR" id="G0S590"/>
    <dbReference type="STRING" id="759272.G0S590"/>
    <dbReference type="GeneID" id="18257305"/>
    <dbReference type="KEGG" id="cthr:CTHT_0032670"/>
    <dbReference type="eggNOG" id="KOG4137">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071116_1_0_1"/>
    <dbReference type="OMA" id="HSKHYCD"/>
    <dbReference type="OrthoDB" id="49520at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029525">
        <property type="entry name" value="INO80C/Ies6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31200">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31200:SF1">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9 10 11" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="6">
        <location>
            <begin position="168"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS21409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="6FHS"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="6FML"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="8AV6"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="8OO7"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="8OOC"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="8OOF"/>
        </source>
    </evidence>
    <sequence length="219" mass="23099" checksum="14F0F6F1BFEB87E8" modified="2011-10-19" version="1">MSNPDAQSAQAAHQALVEQLDLHSIHKTFRNPNWRPNQRRNKTIKAILGESQRKEASSTSAVATPRADDNGGGSGADTPANNDNNDGLSTSGTSTPANGNGSGAGTPASNGQPNLAQASRSLQKLVLEKSLASAQAPDKKAANGFASSAPTATYTNIESAPSLAPMKHYCDVTGLPAPYLDPKTRLRYHNKEIFAMIRNLPQGMGEQFLEARGAHTVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5B0</accession>
    <name>G0S5B0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit delta, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">F-ATPase delta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CTHT_0024170</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692879.1">
        <property type="nucleotide sequence ID" value="XM_006692816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5B0"/>
    <dbReference type="STRING" id="759272.G0S5B0"/>
    <dbReference type="GeneID" id="18256455"/>
    <dbReference type="KEGG" id="cthr:CTHT_0024170"/>
    <dbReference type="eggNOG" id="KOG1758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084338_0_0_1"/>
    <dbReference type="OMA" id="PHQTIYR"/>
    <dbReference type="OrthoDB" id="270171at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.15.10:FF:000003">
        <property type="entry name" value="ATP synthase subunit delta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="entry name" value="F0F1 ATP synthase delta/epsilon subunit, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048938">
        <property type="entry name" value="ATPD_C_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="ATP SYNTHASE DELTA/EPSILON CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822:SF7">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT DELTA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21334">
        <property type="entry name" value="ATPD_C_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="Epsilon subunit of F1F0-ATP synthase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP synthase F1 complex delta/epsilon subunit N-terminal" evidence="14">
        <location>
            <begin position="36"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="F1F0-ATP synthase subunit delta C-terminal" evidence="15">
        <location>
            <begin position="122"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGS20583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="165" mass="17846" checksum="BB7FAF542188F40C" modified="2011-10-19" version="1">MNSLRFARAALRARPALLRAPIQRRGYAEAVSDKIKLSLSLPHQAIYTSQDVVQVNIPAESGEMGVLANHVPSIEQLKPGVVEVIEESGTTKKFFLSGGFAIVQPKSRLSINAVEGYPLEDFSAEAVRAQIAEAQKVASGNGTEQEIAEAKIELEVLESLQAHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5P8</accession>
    <name>G0S5P8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CTHT_0025030</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692963.1">
        <property type="nucleotide sequence ID" value="XM_006692900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5P8"/>
    <dbReference type="SMR" id="G0S5P8"/>
    <dbReference type="STRING" id="759272.G0S5P8"/>
    <dbReference type="GeneID" id="18256541"/>
    <dbReference type="KEGG" id="cthr:CTHT_0025030"/>
    <dbReference type="eggNOG" id="ENOG502RY3D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031730_1_0_1"/>
    <dbReference type="OMA" id="NDWPSSH"/>
    <dbReference type="OrthoDB" id="4849160at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF36">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="CBM1" evidence="17">
        <location>
            <begin position="310"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="262"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="275"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGS20667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="346" mass="36426" checksum="8A01D16522620AEC" modified="2011-10-19" version="1">MVKAKKSAFLATVAGASLVAAHGYVNGIVVNGVYYRNYNPSVDWYRGNNQETLIGWRAENTDNGFVEPNKFNTADIICHRQAVNAKGYATVKAGDKINIKWDPIWPESHVGPVIDYLADCNGDCSTVSKNSLRFFKIDGAGYDKAKGKWAADVLRENGNSWMVQIPADLKPGHYVLRHEIIALHGAANPNGAQAYPQCINIKVEGSGSNSPSGVAGTSLYTANDPGILFNPWVSNIDYPVPGPALIPGAVSSIQQSTSAATRTASATPYAGGAVPTTTQGGSQPTTTALPTTTLVTTTAVPITTAPPAGPTQSKWGQCGGSGYTGPTLCAPGSNCQVINPWYHQCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5Q9</accession>
    <name>G0S5Q9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Filamentation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0025140</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in endocytosis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YPP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692974.1">
        <property type="nucleotide sequence ID" value="XM_006692911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5Q9"/>
    <dbReference type="STRING" id="759272.G0S5Q9"/>
    <dbReference type="GeneID" id="18256552"/>
    <dbReference type="KEGG" id="cthr:CTHT_0025140"/>
    <dbReference type="eggNOG" id="KOG4162">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003276_0_0_1"/>
    <dbReference type="OMA" id="KQPPEQD"/>
    <dbReference type="OrthoDB" id="29013at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051722">
        <property type="entry name" value="Endocytosis_PI4K-reg_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083:SF464">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT DOMAIN 7, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN, TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="707"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1057"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="447"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="739"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="760"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="795"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="810"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="846"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1057"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1095"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1122"/>
            <end position="1133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS20678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1222" mass="133959" checksum="F8B04192A85F2790" modified="2011-10-19" version="1">MPDATKAAHYIQLLDEARCDDNWDAVPELIRKVRKHAPDRTCLTLTAEIEHAVAKANLKGPSDPGSSSSLPGIDPAQQLPSLLTAIENENRYPEDRFQARVCAGWLLWVARDYAGALSRLPQGIDDSDQNSVAGESAAPSSPEWTKVCGLKAAYLRANCMARDGQRDGALLAFEAALPGLSSVWQAGPAESRQQMRYWAELFLTEFCMLASQALREGALSLTDTDCLASFRTWARYWAAGKQSVVSPGGYGFRGSVPRRKVWAEYYFALSEILQRDLPFPTGYSAVTNEGSARSHLRAELKKVETIYQGLLFSETRFPRADEQRAEVEEFVRAMMENWAVLNGRGWKEHDLGPGGRDALCRSTLDALYGAAAKTYHSTAILRHMFRVHLAVAEFDLAFMAFDSWFELVKKGKARVQKTGHPEPALDCDATVLETISACISALCKYGGREAAEKARKLAEEMETLVQKYENQTATDGNQHSQELSPRILALAWQSIGLAQAQWARMTYESEQRASIQEKAIQCLRRSISPQYGSAVDVKAVFTLGVLYAEQRKLSAAVELVKTSLLAETTTVGENPELRLGPYWKERSLIPLWHLLALLLSARQEFIMAARACEGAIEQFKDPYVLFGSRGINGPYRSEHLNEAEASKGTDGIVDEMDDFEKEGILRIKMTQLAILELLEGPEVAVNASTELLSLYPRLFGEVEQKLELSTKPEPPKTAATVRTHRNSIFGSKGDKSSRTRQNSVATTFNHNEPGPSRPQTSHTTATTTLTIQTANGQVADPSASNRSIYAESGRRRSRNSLRKRDRSASRARAVSTASSEPPVPRLDFSAFDGNLPQYNPSESLRSPPPMTSLPPPPVPQQADSSAIRARSRSRSRAATNTHQDELAGLRVGLVGAFPQLLPHVLFSPDHSRRRRKVILVKVWLTIAGFYRRAELLEDAQKAIAEALFVAESLEKEVVNDGSGELSVKQAGWGMEKSVDEVLADVWAEMGHLSVARGKLYQARADYETALSHFQDHPGAIVGLSNILLDIYTEKLLPPPPVEGLDLSSLSLTEEGAASSTPAKATGTFETTAIKTPELPSIPLGLAPTKPKPRRSTSASAAAGSSTSDHAKPNGHPPEQYASPSQTQSSLLGPQLPPPHRATSLPLNDRLAARDRAYGLLSTLTRLGTGWNNSEAWLALARAYEESGQVDKARDALWWCVELEDGRGVREWGVVAGGSGYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5R3</accession>
    <name>G0S5R3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0033330</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2012" name="Nat. Struct. Mol. Biol." volume="19" first="1316" last="1323">
            <title>ATPase-dependent role of the atypical kinase Rio2 on the evolving pre-40S ribosomal subunit.</title>
            <authorList>
                <person name="Ferreira-Cerca S."/>
                <person name="Sagar V."/>
                <person name="Schafer T."/>
                <person name="Diop M."/>
                <person name="Wesseling A.M."/>
                <person name="Lu H."/>
                <person name="Chai E."/>
                <person name="Hurt E."/>
                <person name="LaRonde-LeBlanc N."/>
            </authorList>
            <dbReference type="PubMed" id="23104056"/>
            <dbReference type="DOI" id="10.1038/nsmb.2403"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) IN COMPLEX WITH ADP AND MG(2+)</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693771.1">
        <property type="nucleotide sequence ID" value="XM_006693708.1"/>
    </dbReference>
    <dbReference type="PDB" id="4GYG">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.48 A"/>
        <property type="chains" value="A=1-373"/>
    </dbReference>
    <dbReference type="PDB" id="4GYI">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.20 A"/>
        <property type="chains" value="A=1-373"/>
    </dbReference>
    <dbReference type="PDBsum" id="4GYG"/>
    <dbReference type="PDBsum" id="4GYI"/>
    <dbReference type="AlphaFoldDB" id="G0S5R3"/>
    <dbReference type="SMR" id="G0S5R3"/>
    <dbReference type="STRING" id="759272.G0S5R3"/>
    <dbReference type="GeneID" id="18257371"/>
    <dbReference type="KEGG" id="cthr:CTHT_0033330"/>
    <dbReference type="eggNOG" id="KOG2268">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018693_0_0_1"/>
    <dbReference type="OMA" id="MIHHENT"/>
    <dbReference type="OrthoDB" id="10258631at2759"/>
    <dbReference type="EvolutionaryTrace" id="G0S5R3"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05144">
        <property type="entry name" value="RIO2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000566">
        <property type="entry name" value="Serine/threonine-protein kinase rio2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000052">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030484">
        <property type="entry name" value="Rio2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015285">
        <property type="entry name" value="RIO2_wHTH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852">
        <property type="entry name" value="SER/THR-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09202">
        <property type="entry name" value="Rio2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="17 18" id="KW-0002">3D-structure</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="14">
        <location>
            <begin position="44"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="312"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS21475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PDB" id="4GYG"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PDB" id="4GYI"/>
        </source>
    </evidence>
    <sequence length="373" mass="41809" checksum="336825BAFAA3B05A" modified="2011-10-19" version="1">MGSKNHEIVPTPLIEKIARLRGGSSGVHKSIATLAKAGLIARMKEAKYDGYRLTYGGLDYLALHTHAARKDVYSVGSRIGVGKESDIMIVADEKGKQKVLKIHRLGRISFRTVKANRDYLRNRSTGSWMYLSRLAAIKEFAFMKALYEEGFPVPEPIAQSRHTIVMSLVDALPMRQVSSVPDPASLYADLIALILRLAKHGLIHGDFNEFNILIREEKDAEDPSSITLTPIIIDFPQMVSMDHPNAEMYFDRDVQCIKRFFERRFHFVSTTPGPFYKDAKKTVGKDGAKRLDAALEASGFTKKMAKDLEAAIREQQESRNDEEDSDDYEEDSDKEKASNEDTDVDDGRLQVIGDHVQLGTEGDLKKLTINDGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5X5</accession>
    <name>G0S5X5_CHATD</name>
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        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0025270</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692987.1">
        <property type="nucleotide sequence ID" value="XM_006692924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5X5"/>
    <dbReference type="GeneID" id="18256565"/>
    <dbReference type="KEGG" id="cthr:CTHT_0025270"/>
    <dbReference type="eggNOG" id="ENOG502S997">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033337_0_0_1"/>
    <dbReference type="OMA" id="EHTPEWA"/>
    <dbReference type="OrthoDB" id="2152896at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
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        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="52142" checksum="8BC95BAE73387B0F" modified="2011-10-19" version="1">MASFKDIQTSRPLTHRPALSSSPAPGGGLSITRQAHTRNSSHSLLSSTLNGTHRITRRKSMTNTGANVAALAAALQESGEMSGPLPIASGSRRNTMSKQGLSRQAIVGSLPSPPGSLPNRQFVTDDSGNGNVQDSAIEDEPNDVSGEDAAAAFKKARMRRASDGQPLVKEGGRRFNRPELRCETCGKGYKHSSCLNKHLFVPTFLPLSSPTWWEHTPEWSYTSKLLISKHQQVQLLEAASVLVAMNGNPPRRPTAAAVPAASASVPTTTTTPPDLGRHFSSDRDSSSPPASGYSEQQDRSSADTTPPPHLDDISAPHGSYTSSFGWRDGYGPGAGLSQSYQPGVYGSSVAESVTSVSGFGHLGHFRQPSQDQRPTSSGRNATGKDDRELAAAVEALSCSYNSNTGSRRGPFPTDVPPVPPLPQYLGDDVLSGTSFIGSYPSRAPESFERGAGRRYDIDTKMAEDSDDDDVRSRARSDEDDDGVFGKMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5X6</accession>
    <name>G0S5X6_CHATD</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">CTHT_0025280</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006692925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5X6"/>
    <dbReference type="GeneID" id="18256566"/>
    <dbReference type="KEGG" id="cthr:CTHT_0025280"/>
    <dbReference type="eggNOG" id="ENOG502SD3B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112553_0_0_1"/>
    <dbReference type="OMA" id="WKHAISF"/>
    <dbReference type="OrthoDB" id="4159136at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053203">
        <property type="entry name" value="Cisplatin_resist-associated"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693:SF5">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="164" mass="17690" checksum="6D7127BB190ED3F4" modified="2011-10-19" version="1">MSTDVFRRVGRGGAGNFYSKQEVEKAAKEILTNTTTTAPTYTRAGRGGAGNFTFPTPTSPTSADPSPDLEAQRPPSPSRIEETRAAVAASIAARQRAGGLSGRGGAGNWRDGTDAEKERQRQREEEERKEKEVELQVLKEVDVGLAEPARAYHPVGQGQGYEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6A5</accession>
    <name>G0S6A5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0026060</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693065.1">
        <property type="nucleotide sequence ID" value="XM_006693002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6A5"/>
    <dbReference type="GeneID" id="18256644"/>
    <dbReference type="KEGG" id="cthr:CTHT_0026060"/>
    <dbReference type="eggNOG" id="ENOG502R9MA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_737699_0_0_1"/>
    <dbReference type="OMA" id="HDEGNIL"/>
    <dbReference type="OrthoDB" id="5418627at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="282"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="375" mass="41509" checksum="30C859618FCC359C" modified="2011-10-19" version="1">MDDAARIVSELHNKLAELDGKVAAYQRDMLAEFHRHVADCLKNCPPDVSTEVTRAINDSISAGRYPYLSPPKKDNQEEQRDEDVSEERKPRDGRKSPPLVLRHVSGAPKTGAEVEAELEPEGLRSPHAREREFHGLFTPFYLPLLEGSDRHDEGNILSASPPDTHSLPLVVAGKKQGDEESEGKKSVSDATPSDSDVSSRPEPERRNTDRSVSSISSFGSASEPKPVPMTPRSALRRSSGSSIKNSPRRVRFTVEGEEVFPSDGPKPPSASVSPILTPGSMTPTSEPAPASAAVQLPEAKQVKEKEEKKEEKKEEKKEEKKEEKKEEKKEEKKEEKKEEKKEEEKEERERRRRRGERGGEGGKEKGNQGAGQGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6D3</accession>
    <name>G0S6D3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein BCP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0034510</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Involved in nuclear export, actin cytoskeleton organization and vesicular transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the BCP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693884.1">
        <property type="nucleotide sequence ID" value="XM_006693821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6D3"/>
    <dbReference type="STRING" id="759272.G0S6D3"/>
    <dbReference type="GeneID" id="18257489"/>
    <dbReference type="KEGG" id="cthr:CTHT_0034510"/>
    <dbReference type="eggNOG" id="KOG3034">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068770_2_0_1"/>
    <dbReference type="OMA" id="VKFYRKE"/>
    <dbReference type="OrthoDB" id="27543at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025602">
        <property type="entry name" value="BCP1_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261">
        <property type="entry name" value="BRCA2 AND CDKN1A INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261:SF0">
        <property type="entry name" value="BRCA2 AND CDKN1A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13862">
        <property type="entry name" value="BCCIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028983">
        <property type="entry name" value="BCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR028983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS21588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="296" mass="33603" checksum="59BDABE3F22E69BC" modified="2011-10-19" version="1">MGKKRSREVDAQGDTPMEEPIVEKRDASSDSDDDESSDEDMNIVNVDFELFNYDPEIDFHGVKTLLRQLFDADAQLFDLSGLSDMIITQNTIGSTCKVDGKENDAYAFITVLNMQEHRSKKPIAQLIEYLSERAKTNQDLAGTVPELLASGKHVGLVLSERLINMPAEVIPPMWRFMIEEIEAAVEDKEPYEFTHYLVVSRTYHEVESTLDQTVRKKKKGRAEAELQYFHPEDEEMRKHALASGTYSYIKENEFVSDSKRAFQEAGIKPCGFMMLIEANKIQRAVQAITEFVGTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6H4</accession>
    <name>G0S6H4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-hydroxyacyl-CoA dehydrogenase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0034930</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693925.1">
        <property type="nucleotide sequence ID" value="XM_006693862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6H4"/>
    <dbReference type="STRING" id="759272.G0S6H4"/>
    <dbReference type="GeneID" id="18257531"/>
    <dbReference type="KEGG" id="cthr:CTHT_0034930"/>
    <dbReference type="eggNOG" id="KOG2304">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_2_0_1"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF3">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="3">
        <location>
            <begin position="98"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="2">
        <location>
            <begin position="296"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS21629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="46027" checksum="4F370891BF9A0BAE" modified="2011-10-19" version="1">MNASASSTLAAARSLTTRRALTASLRNIRTFITTSIQELPVAKQAASLRLRNRHVAPVLGITTFKSTFTTSQSFLADKELLTPKWRAPSDESLEYRPVLVVGAGNIGRRVALVWASNSRPVTIYDISQDALREATEYITDNLGAYCAERGTHPGHVCTTTDLRTATTTSGHPERNSAGEITAQEHTRAPWLAIECLPESLPLKTSVLARLERSLPSDCILASNSSSLTTAEMAVEGDLAHSHRLLNTHYFIPPRNRMVELMSSGATSGAIFPFLAMQMRRVGLTPVIVPQGIQSRGFVFNRIWAACKRETLAVLSEGVAKPGDIDALFRDFFHAEKGPCERMDEVGLDTVARVEQHNLERMPWLGSEKALAWLKSNYIEQGKLGEKSGDGLFTVAERDALKERHRLDKYREVEETAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6M9</accession>
    <name>G0S6M9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial-processing peptidase subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Alpha-MPP</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Inactive zinc metalloprotease alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Matrix processing peptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0026780</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693136.1">
        <property type="nucleotide sequence ID" value="XM_006693073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6M9"/>
    <dbReference type="STRING" id="759272.G0S6M9"/>
    <dbReference type="GeneID" id="18256716"/>
    <dbReference type="KEGG" id="cthr:CTHT_0026780"/>
    <dbReference type="eggNOG" id="KOG2067">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009902_5_2_1"/>
    <dbReference type="OMA" id="LKYHHSP"/>
    <dbReference type="OrthoDB" id="277191at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000023">
        <property type="entry name" value="Mitochondrial processing peptidase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000032">
        <property type="entry name" value="Mitochondrial processing peptidase, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF49">
        <property type="entry name" value="MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="12">
        <location>
            <begin position="57"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="13">
        <location>
            <begin position="210"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="13">
        <location>
            <begin position="338"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="251"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="304"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="304"/>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00016741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00030006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00083075"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS20840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="568" mass="62368" checksum="0DC8E8A751C8D6B5" modified="2011-10-19" version="1">MLRTCRPARLLLSRPRVPCSLVEPGILRRSLATKSRAPPIREPTERDQITTLSNGVRVASEDLPDAFAGVGVYIDAGSRYENESLRGASHIMDRLAFKSTGSRTADEMIETVEKLGGNIQCASSRESMMYQAATFNSAVPTTVGLLAETIRDPRLTDEELEQQLETADYEVREIWAKPELILPELLHTAAFKDNTLGNPLLCPQERLGEINRDVIQAYRETFYKPERIVVAFAGVPHEQAVELAQKYFGDMEPSQPQLPRTGSETSLSSQASDSSTTSFDSFSTDSSQSSGILSKIPFLKNLSPRSSRPTSITPLTPEDLSRPAHYTGGFLSLPPQPPPTNPNLPTFTHIQLAFEGLPISSDDIYALATLQTLLGGGGSFSAGGPGKGMYSRLYTNVLNQHGWVESCVAFNHSYTDSGLFGIAASCYPGRTASMLQVMCRELHALTVDTGYAALNPIEVARAKNQLRSSLLMNLESRMVELEDLGRQVQVHGRKIPVREMTRRINALTVEDLRRVARMVVGGLVENPGKGSGAPTVVLHEATAHGITTTKMSWEQIQEIIWQWKLGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6Z0</accession>
    <name>G0S6Z0_CHATD</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="2" type="ORF">CTHT_0035540</name>
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    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006693921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6Z0"/>
    <dbReference type="GeneID" id="18257592"/>
    <dbReference type="KEGG" id="cthr:CTHT_0035540"/>
    <dbReference type="eggNOG" id="ENOG502RKF2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1760052_0_0_1"/>
    <dbReference type="OrthoDB" id="4590349at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409344" evidence="1">
        <location>
            <begin position="21"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="184" mass="18988" checksum="F33EB076C0E3BA67" modified="2011-10-19" version="1">MKFDAKSLFISCLLTGLSSAAPAADPNAQIDLPVLTLTGGIIGPTLAPIPTLIPPTCTKFVDGALVTPSCYTHTTTAPCTTLKSCPLPTKPIVCPAVIKITTISVPCSTDCCPVTPTKTVTPRACQTCITGCVIPTETITVTTGCKPTLTVNPPPTSLTVIRPTLTTIRPPLHTAVIDPILDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7B4</accession>
    <name>G0S7B4_CHATD</name>
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        <recommendedName>
            <fullName evidence="16">Ergosterol biosynthetic protein 28</fullName>
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    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0036250</name>
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    <organism evidence="15">
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        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG28 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7B4"/>
    <dbReference type="STRING" id="759272.G0S7B4"/>
    <dbReference type="GeneID" id="18257663"/>
    <dbReference type="KEGG" id="cthr:CTHT_0036250"/>
    <dbReference type="eggNOG" id="KOG3455">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114589_0_0_1"/>
    <dbReference type="OMA" id="AYAAFHI"/>
    <dbReference type="OrthoDB" id="6485510at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005352">
        <property type="entry name" value="Erg28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451:SF19">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03694">
        <property type="entry name" value="Erg28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="11" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS21758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="19356" checksum="5616F98410D51686" modified="2011-10-19" version="1">MERIYTLLPSGEKGILPYYLFVVGAVALGNAFQNYVTLHYTRRIYNGKFVPNHALPPASDRYNPEDSTQILKPALPSGKDSEKAKDQVTPLAARLFGAYTWLAGLIRVYAAYQIENAGMYQLALLAHVVAAVHFTSEMLVYKTVRFSGPQAFPFAAAYGGTIWMLLQYKHYVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7C4</accession>
    <name>G0S7C4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0036350</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694064.1">
        <property type="nucleotide sequence ID" value="XM_006694001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7C4"/>
    <dbReference type="GeneID" id="18257673"/>
    <dbReference type="KEGG" id="cthr:CTHT_0036350"/>
    <dbReference type="eggNOG" id="ENOG502TG3M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2084593_0_0_1"/>
    <dbReference type="OrthoDB" id="4558032at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408977" evidence="2">
        <location>
            <begin position="22"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS21768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="117" mass="12223" checksum="CC6F1DB118D21C5B" modified="2011-10-19" version="1">MKGITLVFLAATGSLFPVALARPASPLLPRDEAASLTNTTTDITSAEAETNTSDTDVESGTAGKTPSAVAANWGQPQCKTQALYDLCTASNAEAYCDSVGFHNNFMASCKPPNCWCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7I1</accession>
    <name>G0S7I1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lysine decarboxylase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0028220</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693279.1">
        <property type="nucleotide sequence ID" value="XM_006693216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7I1"/>
    <dbReference type="STRING" id="759272.G0S7I1"/>
    <dbReference type="GeneID" id="18256860"/>
    <dbReference type="KEGG" id="cthr:CTHT_0028220"/>
    <dbReference type="eggNOG" id="ENOG502QSR9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058336_1_0_1"/>
    <dbReference type="OMA" id="HQKPIGL"/>
    <dbReference type="OrthoDB" id="414463at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.450:FF:000018">
        <property type="entry name" value="Lysine decarboxylase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00730">
        <property type="entry name" value="Rossman fold protein, TIGR00730 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31223">
        <property type="entry name" value="LOG FAMILY PROTEIN YJL055W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31223:SF70">
        <property type="entry name" value="LOG FAMILY PROTEIN YJL055W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102405">
        <property type="entry name" value="MCP/YpsA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS20983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="25614" checksum="3B5A4CD962B89B02" modified="2011-10-19" version="1">MSTSESQSAATPRTKICVYCGAHRGVNEKHLEAARSLARAMAANNIQLVYGGGTVGIMGELAKTLVSLAGPDSVHGIIPEPLVRYERDLAKTNMNGECSSSSKTEDKVVLPEESVFGRTTVVKDMHTRKRMMAQEVIEGGPGSGFIALSGGYGTVEELFETATWNQLGIHSKGIVLFNVDGFYDGILSWINKSVEEGFISQANKKILVEAKTAEEAIQALRDYKTSEGVLKLTWGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7I3</accession>
    <name>G0S7I3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0028240</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693281.1">
        <property type="nucleotide sequence ID" value="XM_006693218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7I3"/>
    <dbReference type="STRING" id="759272.G0S7I3"/>
    <dbReference type="GeneID" id="18256862"/>
    <dbReference type="KEGG" id="cthr:CTHT_0028240"/>
    <dbReference type="eggNOG" id="ENOG502RP9B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035068_0_0_1"/>
    <dbReference type="OMA" id="GHLVWED"/>
    <dbReference type="OrthoDB" id="5221663at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="486" mass="53763" checksum="CC99A9D165866CC3" modified="2011-10-19" version="1">MSSAAGGAGISGNSSNSNTTTNTSTGRGGWKGKERESIPPPPSHSSAPYDQDDIPQTVGTLLASIATCMTDALDALSQVTVAADSQQLAERNEHLREMELALDEAKQDFQELAPLVHGRGWYENDRSEESLAELEILLTHFTSHSLALQNWAFSYLNPSKQVQFSNGALSSPTSPGSQSNGSPIDPRMTPRLRKALHRAQRRAAHRVFAAQHQEEQSQPRCLGAWLVYRQLRRRHQVGEEGERSRERQRRKSRHRAEEREGLGLELEELPSNRGQDVRQHEKTMNGGYPDNLRAQGSEEMPYDCMRRGSLQRRGSLEELVPHCNYIGRFQRLASGGNGELLDAAFVCDFCNGYIVWSDLQDMPSERTPRTASSDAAAGGYPHWQARGHSATTGEEKTIVFAPLAIANHTAPEPGEWQAGLVCPYCEEATYLDAGEDSSEVKYVQDEKGFADLRHFQEHLEWYHTAAVPSLSELAAALPPGESCNVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7I6</accession>
    <name>G0S7I6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0028270</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP5 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693284.1">
        <property type="nucleotide sequence ID" value="XM_006693221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7I6"/>
    <dbReference type="STRING" id="759272.G0S7I6"/>
    <dbReference type="GeneID" id="18256865"/>
    <dbReference type="KEGG" id="cthr:CTHT_0028270"/>
    <dbReference type="eggNOG" id="ENOG502QQIZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050414_0_0_1"/>
    <dbReference type="OMA" id="WEPESTF"/>
    <dbReference type="OrthoDB" id="166907at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19496">
        <property type="entry name" value="Elp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019519">
        <property type="entry name" value="Elp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10483">
        <property type="entry name" value="Elong_Iki1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS20988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="362" mass="40141" checksum="B5ABCFAF43FC8472" modified="2011-10-19" version="1">MGVQHQAVKRAHNLLLFKNLLESKDNASPLTLVLDSLEQSAQPLTHEFMRLAKTLKRAKVIFVSFSTVKKPALADVFVRAWSKTLQTIATEITTAITNKQESKSPYTKTHFFLSLLTSLSITEHLIVIDSLNTPASLTPHLFPTFFSSVITSPCTTLVAVYHTDIPVLPPSRSALDAGYNPDYSPDPETLLCHLATAVLRVSCLHHEIAAHRARERSLIEPKWGLKEGREGVLIGLRKGNGKGDDSGGAVGLVVEMEVRRRSGRAISGEFVLVPAGQDYKETGLRVMLKGEYPAFKKEVVEEEEEKPEATFDLGLTEKQRRDREGVVLPYFDAQVEVGGGEGGRILYEMGREDDFDEEEDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7Q8</accession>
    <name>G0S7Q8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0028480</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693304.1">
        <property type="nucleotide sequence ID" value="XM_006693241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7Q8"/>
    <dbReference type="STRING" id="759272.G0S7Q8"/>
    <dbReference type="GeneID" id="18256886"/>
    <dbReference type="KEGG" id="cthr:CTHT_0028480"/>
    <dbReference type="eggNOG" id="ENOG502SPGI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013858_0_0_1"/>
    <dbReference type="OrthoDB" id="4966at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="832"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="835"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="881"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="938" mass="109040" checksum="99D71DA3AD9FF677" modified="2011-10-19" version="1">MASPFNPNNRPANPVSLINPANVGEDGNPLPSIASLNLNGFIPDEQARLAAARASRQRATYEEIAARSINPDVQSFIEHINKNPTHSFKRKKIGIDALKKIFEEEEEEKEEEEEEEEEEEDSEDERQALARRLQKEEEKKRCEEEEFQREWNALMKVSKVQEVDPELVARFQHIARVRIQMMRRATEEWDKLHVQPKPKRINILRRLCRIPELVVEVGKHLRPVDLVNLYSVSRDFHDTLNNQMRSFVLAWASHMAPIGSHIYSSPMYYKYFTKDPAGNLVTELDKEAMKPKPGQPSLPDMWPFNRDGVVRKIPGLQWLQMVVNREIRVRDILAVLARNGHRMPKGSHLTLHKLWVIMDIATSETRVNLLKDQEFFTDEDLYIAQQFMVKLVLHFNSPYCGPQTTRLMRLMMGQPSLSVLWALLRRKKYTTREEIRALKLRYDVPPESVHANMRLCGVPIEEMGIMHLEGWGAGDGHLLRPDELIPLEAMRRMLPLHQYIDDMMIYGHINLETGDPEVPSVEEMYMSDDELGPMYKCWEPMHNTPINGGCGNVPFEWKNWQPKHARKARWDELTEEERQMIIDDDKREMKACRDIEGAQHEFERVRDKLLRQVLACRTHKRHMKSKTFRVYEIALEDMAQELIAVQVAATTSNNPDAMDIDSKPVITTVTSPNDISDSEIDKDLTLEPIPQNDPVAFWRRRSTTRRYYDYSQWDDDFEESLSSSSASEDDEDSFRKKYKKLLDEMSEKLKQKMPAHVTTFSIGCIPAIKHSKRPAQGPSRSTAITDEELLAQADQEYADEELDLDSDGLCENGLATPFDWDDYVSHPEKYLAGEADLDEEKEEEYEGDEELEGDEEWEGDEEWEGNEMENDFESDGAGNFSDEDEFGEEEEWQDEGEEDEQHVTAAHIEIEHDVAMYFAAEEAEDQESERMMNWYRPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0S860</accession>
    <name>G0S860_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Altered inheritance of mitochondria protein 41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">AIM41</name>
        <name evidence="3" type="ORF">CTHT_0029480</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM41 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693403.1">
        <property type="nucleotide sequence ID" value="XM_006693340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S860"/>
    <dbReference type="GeneID" id="18256986"/>
    <dbReference type="KEGG" id="cthr:CTHT_0029480"/>
    <dbReference type="eggNOG" id="ENOG502SDB7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_799260_0_0_1"/>
    <dbReference type="OrthoDB" id="538640at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016884">
        <property type="term" value="F:carbon-nitrogen ligase activity, with glutamine as amido-N-donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.10">
        <property type="entry name" value="Uncharacterised protein YqeY/AIM41 PF09424, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019004">
        <property type="entry name" value="YqeY/Aim41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042184">
        <property type="entry name" value="YqeY/Aim41_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 41, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 41, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09424">
        <property type="entry name" value="YqeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="GatB/YqeY motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS21107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="347" mass="38106" checksum="36BB57A375584096" modified="2011-10-19" version="1">MSSKAAFSNLIRTLGQPVVRRPAITTTRLAFIRGARPYSSTDIPPPPLLSKIKDDLKTAMRAKDQNRLSVLRAVLAAVVNASKTDAPIKTDVQLVVLLRKSAAKSREAAAEARMAGREDLAEKEEAQAKILEEYAESSSVRELTVDDLRKQVEATKAQLIGEGVKANQLFGQMMGKLMGDKVSPIANCVYDKAALVKLIREACQNESKPSRTTATTTTTTTITTITPEELEQQEEGTAAQPKKKERKKMRKKFLPVPTYADLYKIVKEESEKLVAEGCEQNKLRGRLLALLMPSTGPLKDLLKDWFIPRSFLVGVIKDVVRHRRLAMTTPSNGASAVVSTSDSTTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0S891</accession>
    <name>G0S891_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">THO complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0037990</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694221.1">
        <property type="nucleotide sequence ID" value="XM_006694158.1"/>
    </dbReference>
    <dbReference type="SMR" id="G0S891"/>
    <dbReference type="STRING" id="759272.G0S891"/>
    <dbReference type="GeneID" id="18257837"/>
    <dbReference type="KEGG" id="cthr:CTHT_0037990"/>
    <dbReference type="eggNOG" id="KOG1874">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000511_1_0_1"/>
    <dbReference type="OMA" id="QERWTCI"/>
    <dbReference type="OrthoDB" id="29024at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040007">
        <property type="entry name" value="Tho2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021418">
        <property type="entry name" value="THO_THOC2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021726">
        <property type="entry name" value="THO_THOC2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032302">
        <property type="entry name" value="THOC2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597">
        <property type="entry name" value="THO2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11262">
        <property type="entry name" value="Tho2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11732">
        <property type="entry name" value="Thoc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16134">
        <property type="entry name" value="THOC2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THO complex subunit 2 N-terminal" evidence="8">
        <location>
            <begin position="141"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 N-terminal" evidence="7">
        <location>
            <begin position="870"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 C-terminal" evidence="6">
        <location>
            <begin position="1210"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="550"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1138"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1554"/>
            <end position="2651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="550"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="582"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1138"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1159"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1554"/>
            <end position="1564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1575"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1589"/>
            <end position="1600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1620"/>
            <end position="1633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1636"/>
            <end position="1645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1715"/>
            <end position="1761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1768"/>
            <end position="1784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1801"/>
            <end position="1823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1831"/>
            <end position="1841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1863"/>
            <end position="1874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1887"/>
            <end position="1934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1943"/>
            <end position="1952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1959"/>
            <end position="1991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1992"/>
            <end position="2001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2103"/>
            <end position="2113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2192"/>
            <end position="2201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2252"/>
            <end position="2263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2283"/>
            <end position="2301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2327"/>
            <end position="2352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2413"/>
            <end position="2489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2496"/>
            <end position="2513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2531"/>
            <end position="2555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="2569"/>
            <end position="2588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2604"/>
            <end position="2618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="2635"/>
            <end position="2651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS21925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="2651" mass="294946" checksum="007FAD3F37060BEE" modified="2011-10-19" version="1">MPPKRKRNDRGPNDAGLSRPAPHRPGDMTLSQHERSFDGLRRGPPRNARRGDRRDSYTPNSSTNASAPVSPSLPRPPSSSSSMAAPPPPAPPQPPPAPAVTPAPATSTPAPASMPAPPPPSSSAPAAASTHIPYVYEYTIITDDHLSRWTKGARQEIIDHGIQSRDDEDLTEVAMIFQELIHSVTDGRLPGAEAGGVVKEILGPEISEEDRKNGAFDPHTLFLDTVSTFVDVESGPLHPQLRDFMMATEVSPALMRVVLDPEILQHLDLIRSTFVRMGIRNSTNLLYRQANYNLLREETEGFSKLVTELFTTSNSEPPSSEVVQATFNRVMGLIGTFDLHPGRVLDVTLDVFASVLIKQFRFFIKFLRISSWWPRSQLQMRTDVFTGGLPIWALPDHYGWTATEEEEAALEQQRLQRDIAFWDRARDLKLKAFFELGGRQLLPSDEERARSDVSDDDVSPENAIEREWIKITQTRPPPGNRDAAQMLGFKLRFYTSEFRNAEDTLPANLLYLIALLIKVGFISLTDLWHHIWPLDEDMERVKAQRFKELEEKEKANRPGGEKNALTMAGALPDDMPPPPSNNRREAEAKKEPETKKEEQAEEKPKLPEPNDQKVDLLRCLLTIGALPESLFIIGRHDWLLEGYPDIIPLFHRIIHHSIEKVYQETQPRATMSMDCGMKKLPDIDQSGVPKGSVKLTTPIVRRALRWPFPDKADVSDGPSYRFYWDEWADNVPVCQTVDDVFTLCDTLVNVIGVHIGQDASLVAKLAGIGCKSLADDPSPANMNRWLDLLKRLLVPALSLSETNSSIVEAVWSLLKQYPIKTRYGVYAEWYEGQTSRLEPIRKAFHRTRLETLSKLKRLSLTNIPQMAKALAKIAYPSPGIVCKVALAQIESYSNLIEAFVECAKYFTDLGYDVLVWSVLSSLGGQQRSRTQESSVLLTSKWLQALSRFSGKVFARYPNMDASPVLRYVHSQLLRGNSTDLVILKELIGSMGGIVPDVDFTDAQLRAMTGGELLRRETLVNLGDQRAVSVKSAARLMKALSRSNLAAQLLINIAQYRQNAIYNTADASAHIKYLSAIVDDTHQILSQYLDLLRSNLDPETFDKLVPDIIQLIKDYGLDVNLAFMIRRASIRWEIKGTATTSTPTKDATTKPVTDIDGDVAMEPAPAENATPEAKDESAAASQKSSGRPESLSEALAPLIEQIPSVLPRQTWQYITPAGYVFFWSLQLGNLVFPQDSYLAEGARLKKQAEEVMRDRSDMTRAGMNKKTRKRDDILDRQKALLQEANEGITRFSKARLHIGRQVASWFPADISKADQTADTLLEECILPRLQLGALDAEYCFRLIKFLHEFSAPNFKLMSLYDRLFNHNRLRAMIFTCTVREAEHLARFLRLILADLSKWHGDKSAYEKEALGLKDLQGTKTRHYLGFATAFDADGKPTEFVEHDPFKEMLFRWHKELNSALRSCLNGLEWMHIRNAITILKGVIDYFPAINFMAEKFLEQLKTITEREAASKNAPESEQQGHRVDLSVTAQTTYSELQKRRSKWILVQAFRSGVVSAPATSARAPASGPPPPSDQPQKTDAKENKDEDRPSTTASSTLRAAAPEFKPDGAARSQQQSEVEDGEVKDIKAPARSREPPAGLPKPPPSREQPSRDAGTSSQRPGTPATAPSKPPTPAPAASSGRPEPPKFSTLPPGGHGLPNRPELPSRPEPIPRFGQGRHDRRDIPMRDSRDYRDSNRDPRDPRDQHPRDMREPHGGRDSRDYRGPPPEPSRLDRPRDLPPLDRRPPPPEPSSRDGGWGPSRGEPPRWHDHGPPPDRDNRGPRERLPPPSSSRPDSRPSREAPKEPAPAPAPSAQNSPQEPPINPDRARIIEADRPEIINPARAALINESSREPPSRSPRDHPPRDQPSRERPPRTESPRRSDRDRDRDRDRDRDRQPPSAPQQESARDSRDDRHSRHRHSDRPGTPREAHEPPVSHAHPRPERDRNQEREERMPPPPPPPPRDQPYGGPPSRSDHDHPGRLNQQDPNYGRLNPIPTVDVGGGPPSGPRGRGGRNATRPGPVNGPPMRPSDPRFPSMMEPMRPPSPSERHPPTGPSASRPPRRGQYDSNPNMHSPPTSVPAGPGVHPDRMRHMQQGMPPSGPSGIHPDRLSHISGGGQPTGPAGPHSRGPPPMSTPDRPSMSAPGSGSGSGSGSGSRPAPTGPSNDFPASTPTGPAAGNTMNDRLRSGGRQLRGIQNTLDKAAAAAASPDPRSLRMSQRTSRQSLAGSDAQILAGGAGTSPVSTPTHDRPPQDHPLRESTRSDRGPPGPPTSSGRGEPMPLTMSIQVAPDSRENTYKDRDRADRERQDRERDHHGRNGPAGLVNGAQEEYAASRSEHERARREHHRSSGLAGSATAPEGPSRGSGGSSGARSSRRSSRERGERERERERSPVRPSERGERERERERERERDRSERERGGEKERDRERDRERERDRDRGDREYRDRNERERDREHHHRDRSGARDERPERSERRSGREPAPSGGPVRDLLAPPPREPRDGSGHRSGSHHREGSSSRMSEDYPPARSSRGAPPTSVPPPPPPPPPPPPPPGPPREPRELRSRMGGGMPPDDHHGHRGGGDDRNNRKRRGEGPPMEVSGHGHGHGGHGGHVDKRPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8A5</accession>
    <name>G0S8A5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Multidrug resistance protein fnx1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0038130</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694235.1">
        <property type="nucleotide sequence ID" value="XM_006694172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8A5"/>
    <dbReference type="GeneID" id="18257851"/>
    <dbReference type="KEGG" id="cthr:CTHT_0038130"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_3_1"/>
    <dbReference type="OMA" id="YINLCLG"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF67">
        <property type="entry name" value="MFS MULTIDRUG EFFLUX TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="449"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="560"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="74"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS21939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="592" mass="62296" checksum="0B0DE717A7994D08" modified="2011-10-19" version="1">MTVNADSQRVGPGAGVDSERRDVESLSPKHSAHTTVVPIPDEETPLISENGTAAPASTEPQWLGGLTTKRFQLLFLQIVIGNFVACFDGTIMASSHPAITSSFGSSNAASWLSTAFLLTSTSFQPVLGSLSDGLGRKSPYVATVAIFLVGTAACALAPSMGAFIAARALCGLGAGGMMTLGIIILSDVVPIEIRGKYQGYLNVVFGVGSMMGAALGGLMADTLGWRWEFGVQVPLLVGCLALSMVIVPADLGLYGREQKPLGEVMRNFDLRGSILMASSVTCLIIGLVGLRGYSSRLDTDADFPQSLGGNILPWSHPVVIASLVLFAILFPIFLHVESNPPAGVKPVMPIHLLTKQPQSNLLFSNHLAFLVSSAVIFNAPLYFQGVLLTSATTSGLRLVASSVVTSIVGTTTGFLITYTRRMKWAVAGGTAILTAGTALLAAQRPGWPGWVYVLFLVPQAAGCGLAFPGTLMAVLAVAPQEEQAVVTGTLTLWRSLGSVMGVATSSLVMQNALRVYLEKYVSAPTLEEKEKIVQLVRKSVEAIKALPDGYRAQVVTSYGAALRVTFVATCVVAALSMLLVLPVRLPKLTKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8Y4</accession>
    <name>G0S8Y4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0043870</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2017" name="Nat. Struct. Mol. Biol." volume="24" first="954" last="964">
            <title>3.2-A-resolution structure of the 90S preribosome before A1 pre-rRNA cleavage.</title>
            <authorList>
                <person name="Cheng J."/>
                <person name="Kellner N."/>
                <person name="Berninghausen O."/>
                <person name="Hurt E."/>
                <person name="Beckmann R."/>
            </authorList>
            <dbReference type="PubMed" id="28967883"/>
            <dbReference type="DOI" id="10.1038/nsmb.3476"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.20 ANGSTROMS)</scope>
    </reference>
    <reference evidence="8 9 10" key="3">
        <citation type="journal article" date="2019" name="Mol. Cell" volume="75" first="1256" last="1269.e7">
            <title>Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration.</title>
            <authorList>
                <person name="Cheng J."/>
                <person name="Bassler J."/>
                <person name="Fischer P."/>
                <person name="Lau B."/>
                <person name="Kellner N."/>
                <person name="Kunze R."/>
                <person name="Griesel S."/>
                <person name="Kallas M."/>
                <person name="Berninghausen O."/>
                <person name="Strauss D."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="31378463"/>
            <dbReference type="DOI" id="10.1016/j.molcel.2019.06.032"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.50 ANGSTROMS)</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694780.1">
        <property type="nucleotide sequence ID" value="XM_006694717.1"/>
    </dbReference>
    <dbReference type="PDB" id="5OQL">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="K=1-938"/>
    </dbReference>
    <dbReference type="PDB" id="6RXT">
        <property type="method" value="EM"/>
        <property type="resolution" value="7.00 A"/>
        <property type="chains" value="UN=1-938"/>
    </dbReference>
    <dbReference type="PDB" id="6RXU">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.50 A"/>
        <property type="chains" value="UN=1-938"/>
    </dbReference>
    <dbReference type="PDB" id="6RXV">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.00 A"/>
        <property type="chains" value="UN=1-938"/>
    </dbReference>
    <dbReference type="PDB" id="6RXX">
        <property type="method" value="EM"/>
        <property type="resolution" value="7.10 A"/>
        <property type="chains" value="UN=1-938"/>
    </dbReference>
    <dbReference type="PDB" id="6RXY">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.70 A"/>
        <property type="chains" value="UN=1-938"/>
    </dbReference>
    <dbReference type="PDB" id="6RXZ">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.40 A"/>
        <property type="chains" value="UN=1-938"/>
    </dbReference>
    <dbReference type="PDBsum" id="5OQL"/>
    <dbReference type="PDBsum" id="6RXT"/>
    <dbReference type="PDBsum" id="6RXU"/>
    <dbReference type="PDBsum" id="6RXV"/>
    <dbReference type="PDBsum" id="6RXX"/>
    <dbReference type="PDBsum" id="6RXY"/>
    <dbReference type="PDBsum" id="6RXZ"/>
    <dbReference type="AlphaFoldDB" id="G0S8Y4"/>
    <dbReference type="EMDB" id="EMD-10051"/>
    <dbReference type="EMDB" id="EMD-10052"/>
    <dbReference type="EMDB" id="EMD-10053"/>
    <dbReference type="EMDB" id="EMD-10054"/>
    <dbReference type="EMDB" id="EMD-10055"/>
    <dbReference type="EMDB" id="EMD-10056"/>
    <dbReference type="EMDB" id="EMD-3847"/>
    <dbReference type="SMR" id="G0S8Y4"/>
    <dbReference type="IntAct" id="G0S8Y4">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S8Y4"/>
    <dbReference type="GeneID" id="18258425"/>
    <dbReference type="KEGG" id="cthr:CTHT_0043870"/>
    <dbReference type="eggNOG" id="KOG2172">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003783_0_0_1"/>
    <dbReference type="OMA" id="QVIEPMD"/>
    <dbReference type="OrthoDB" id="277439at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006709">
        <property type="entry name" value="SSU_processome_Utp14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150:SF12">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04615">
        <property type="entry name" value="Utp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7 8 9" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="379"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="522"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="604"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="809"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="195"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="534"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="606"/>
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        </location>
    </feature>
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        <location>
            <begin position="633"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="662"/>
            <end position="677"/>
        </location>
    </feature>
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        <location>
            <begin position="723"/>
            <end position="739"/>
        </location>
    </feature>
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        <location>
            <begin position="746"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="768"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS19895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="5OQL"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="6RXT"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="6RXU"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="6RXV"/>
        </source>
    </evidence>
    <sequence length="938" mass="104553" checksum="786ED74F158E1FBC" modified="2011-10-19" version="1">MPGRQAHGRPLLPSLGSSSGGGKSKKSRSKARRSAQSKALDAFALAAEQVPESRSKGVRLRDLDEHPSTSASRNKRQHEDDEEDDFDGFDDDEGMGRKKRARRDSGGDEDGDDVDEDMEGGADGEDDSEEWHVGVTGADEDSEIDSDEAFGESDEERFEGFVFGGSKSHKKGTKKRRNGSEDDAIDLATALDQYESSEEGEEGEESESEEDDEESEEEDSDEEDDDPSKLDALQSMIAGFAGEDEESGGEGEAKPSGKQKLSLKDLGLVGVKDPDMKRSLRLMKKEEKATKPGSSKKLEVPLAKRQQDRLMREAAYKKTNETLDRWIETVKHNRRAEHLVFPLAQNAHDRGLDASELQPITQKTSGTELEQTILAIMEESGLGPTAKPEKKETSGEAGKQGMSKEEQKELIRQKRRERELHSREMARLKRIKKIKSKTWRRIHRKELLKNEEAAYQAALEAGELDSEEEREALDRRRALERVGARHKESKWAKLGKKAGRAVWDEDFRAGLAEMARRKDELRKRIEGLKNGSDDSSDDSDGDEDASGDEAAERRKLLAELEKAAAYSDDDEPHSKLFQLKFMQRGEELRRKENEELIAQIRRELDSDYDGSEPDEVEIGRRTFGMGKKDKTEQQQAQDQLARMQAAEARKEKAAARVAAAEETVKQEAREKAEKDEASAPSTAGAWSQPKVEAGAWSKPDDEGSSKPRKAPKGRPEEIDVTDLALAGKPAKAKANGQAKSQVQGKAHASNGQSSSSQKASTSVAITGAEEDGNDSDDSDAVHLPMAIRDRALIERAFAGDDVAAEFEKEKAEIEADDDEKEIDNTLPGWGSWVGEGVSNREKRRHQGRFVTKVEGIKKEKRKDYKLKDVIINEKRVKKNDKYLATGLPHPFESQQQYERSLRLPVGPEWMTKETFQDATKPRVIIKQGIIAPMSKPMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9A4</accession>
    <name>G0S9A4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWR1-complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0045120</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SWC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006694837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9A4"/>
    <dbReference type="STRING" id="759272.G0S9A4"/>
    <dbReference type="GeneID" id="18258550"/>
    <dbReference type="KEGG" id="cthr:CTHT_0045120"/>
    <dbReference type="eggNOG" id="KOG2656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018539_3_1_1"/>
    <dbReference type="OMA" id="GNTTMYQ"/>
    <dbReference type="OrthoDB" id="19740at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032563">
        <property type="entry name" value="DAMP1_SANT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027109">
        <property type="entry name" value="Swc4/Dmap1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855:SF10">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16282">
        <property type="entry name" value="SANT_DAMP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DAMP1 SANT/Myb-like" evidence="9">
        <location>
            <begin position="137"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="96"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="345"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="537"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
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        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="537"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="590"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="636"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="667"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS20015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="707" mass="76845" checksum="C9A1A5650099588C" modified="2011-10-19" version="1">MTSNDVRDVLNLPSDASVPRPSRKQKPTAPRPNLKGLAREVQNLGGDTPIAIVPEISFKKRRFASRKPAARWVLKPFTNSARNDGGALVLRHWRRKTPLDGAPPPDHTPESESLAGEGVAAAGGTGTNEDEKPEDSAFAKFNVKVQVPSYTDEHYQSHLQHADWTKEETDYLMELAREFDLRWTIIWDRYEFVPKALKQEQEGETNGETSTAVVPAPRQRTMEELKARYYEVAAKMMAVHKPAQYMTAPEFELYEMMQNFNPEQERRRKEFALNTMSRSRDEAREEESLLLEIKRILARTERFNEERRELYHRLDYPSTDADINSFKSSAGLQALLQNLMSSDKAKKRRSIMPGDGVSPGGVVPASATSETAPSGPGGGGGGGHNRRESIAATSSHSRRESESTRGAPATPAEPTPTSATASGTNASNKKKSTAQQPERRKLSPQEEQIYGVSYHDRLGSGPTFRYEKINKLYSHKSGQQQLRITNALAELDVPARLVMPTAAVTAQFEILWGAVTALVDLRKVSDKLDAEIKVEMAKKAERERQKALERGETGEDGGKKEEGQGEKKKDGQGQGEGEKKEGEEKDKTVASTSAAGSASAPSSEAPNGAGASASEESKPAAGSEAQQQQQQQQQQQKEKEKEIKQEPGSDSASAATSGIEEKPQPGSSGGTSIGTGGGGGGGDGTAHKRSASVISAGSDKSAKRVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9A5</accession>
    <name>G0S9A5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0045130</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694901.1">
        <property type="nucleotide sequence ID" value="XM_006694838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9A5"/>
    <dbReference type="STRING" id="759272.G0S9A5"/>
    <dbReference type="GeneID" id="18258551"/>
    <dbReference type="KEGG" id="cthr:CTHT_0045130"/>
    <dbReference type="eggNOG" id="KOG1690">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066963_2_1_1"/>
    <dbReference type="OMA" id="GATCAWQ"/>
    <dbReference type="OrthoDB" id="3427at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409045" description="GOLD domain-containing protein" evidence="9">
        <location>
            <begin position="17"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="26"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS20016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="219" mass="24675" checksum="CFC0518BBA31D6BE" modified="2011-10-19" version="1">MRTLFSLLSLAAAARALYFYIDVTQPKCFYEELPKDTLVVGHYVAEEYDDHRQVWAKHDGISIYISVDEVFDNDHRVVSQRGGPSGKFTFTSAEAGDHKICFTPSSSSGRSNWLSVSAPNGGIRLTLDIAIGETSAMDGADKGKIADLATRVKDLNARLNDIRREQVFQREREAEFRDQSESTNARVVRWILIQLTVLGVTCAWQLSHLRSFFIKQKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9G0</accession>
    <name>G0S9G0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0045750</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="3 4 5" key="2">
        <citation type="journal article" date="2025" name="Proc. Natl. Acad. Sci. U.S.A." volume="122" first="e2507279122" last="e2507279122">
            <title>Structures of &amp;lt;i&amp;gt;Chaetomium thermophilum&amp;lt;/i&amp;gt; TOM complexes with bound preproteins.</title>
            <authorList>
                <person name="Agip A.A."/>
                <person name="Ornelas P."/>
                <person name="Yang T.J."/>
                <person name="Uboldi E."/>
                <person name="Hader S."/>
                <person name="McDowell M.A."/>
                <person name="Kuhlbrandt W."/>
            </authorList>
            <dbReference type="PubMed" id="40674418"/>
            <dbReference type="DOI" id="10.1073/pnas.2507279122"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694956.1">
        <property type="nucleotide sequence ID" value="XM_006694893.1"/>
    </dbReference>
    <dbReference type="PDB" id="9I6B">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="G/H=1-84"/>
    </dbReference>
    <dbReference type="PDB" id="9I7P">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="G/H=1-84"/>
    </dbReference>
    <dbReference type="PDB" id="9I7S">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="G/H=1-84"/>
    </dbReference>
    <dbReference type="PDB" id="9I7T">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.80 A"/>
        <property type="chains" value="G/H=1-84"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9G0"/>
    <dbReference type="EMDB" id="EMD-52652"/>
    <dbReference type="EMDB" id="EMD-52658"/>
    <dbReference type="EMDB" id="EMD-52660"/>
    <dbReference type="EMDB" id="EMD-52661"/>
    <dbReference type="GeneID" id="18258613"/>
    <dbReference type="KEGG" id="cthr:CTHT_0045750"/>
    <dbReference type="eggNOG" id="ENOG502SY3V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_183924_0_0_1"/>
    <dbReference type="OMA" id="LQKPCVN"/>
    <dbReference type="OrthoDB" id="5403997at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3 4 5" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS20071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="3">
        <source>
            <dbReference type="PDB" id="9I6B"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="9I7P"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="9I7S"/>
        </source>
    </evidence>
    <sequence length="84" mass="9001" checksum="AD16248B03ECEABD" modified="2011-10-19" version="1">MPPKRVSYNSRRSLNPITGAYNALFVSENASIVRSVVAFGLAVTFLASGWAEAILSCVPSPLVSSRQQQPPLTDLQKPCVNGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9G3</accession>
    <name>G0S9G3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucanase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0045780</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 7 (cellulase C) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694959.1">
        <property type="nucleotide sequence ID" value="XM_006694896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9G3"/>
    <dbReference type="SMR" id="G0S9G3"/>
    <dbReference type="STRING" id="759272.G0S9G3"/>
    <dbReference type="GeneID" id="18258616"/>
    <dbReference type="KEGG" id="cthr:CTHT_0045780"/>
    <dbReference type="eggNOG" id="ENOG502SJT6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020817_0_1_1"/>
    <dbReference type="OMA" id="ALCPDKK"/>
    <dbReference type="OrthoDB" id="412382at2759"/>
    <dbReference type="BRENDA" id="3.2.1.4">
        <property type="organism ID" value="1279"/>
    </dbReference>
    <dbReference type="BRENDA" id="3.2.1.8">
        <property type="organism ID" value="1279"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07999">
        <property type="entry name" value="GH7_CBH_EG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.100.10">
        <property type="entry name" value="Glycoside hydrolase, family 7, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001722">
        <property type="entry name" value="Glyco_hydro_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037019">
        <property type="entry name" value="Glyco_hydro_7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753:SF1">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE CELB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00840">
        <property type="entry name" value="Glyco_hydro_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00734">
        <property type="entry name" value="GLHYDRLASE7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409414" description="Glucanase" evidence="10">
        <location>
            <begin position="18"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS20074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="425" mass="47039" checksum="95C6715CF1F1F207" modified="2011-10-19" version="1">MARKFALLSLLLGLASAQKPGNTPEVHPKLTTYRCTHLQGCRPETNYIVLDSLSHPVHQVNSNANCGDWGNPPPRNVCPDVETCAQNCIMEGIPDYSAYGVTTSGSSLRLKQIHQGRVTSPRVYLLDKTEQQYEMMRLTGFEFTFDVDATKLPCGMNAALYLSEMDATGARSRLNPGGAYYGTGYCDAQCFVTPFINGIGNIEGKGSCCNEMDIWEANSRSQSIAPHTCNKQGLYMCSGQECEFDGVCDKWGCTWNPYKVNVTNYYGRGPQFKVDTTRPFTVITQFPADQNGKLTSIHRMYVQDGKLIEAHTVNLPGYPQVNALNDDFCRATGAATKYLELGATAGMGEALRRGMVLAMSIWWDESGFMNWLDSGESGPCDPNEGNPQNIRRIEPEPEVTYSNLRWGEIGSTYKHNLKGGWTGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9R0</accession>
    <name>G0S9R0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0046790</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UFD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695056.1">
        <property type="nucleotide sequence ID" value="XM_006694993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9R0"/>
    <dbReference type="STRING" id="759272.G0S9R0"/>
    <dbReference type="GeneID" id="18258717"/>
    <dbReference type="KEGG" id="cthr:CTHT_0046790"/>
    <dbReference type="eggNOG" id="KOG1816">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012913_0_0_1"/>
    <dbReference type="OMA" id="THLKHHE"/>
    <dbReference type="OrthoDB" id="193703at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.50">
        <property type="entry name" value="Ubiquitin fusion degradation protein UFD1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.130.10">
        <property type="entry name" value="Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain (AZUL)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032353">
        <property type="entry name" value="AZUL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042556">
        <property type="entry name" value="AZUL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056012">
        <property type="entry name" value="DUF7590"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004854">
        <property type="entry name" value="Ufd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042299">
        <property type="entry name" value="Ufd1-like_Nn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055417">
        <property type="entry name" value="UFD1_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055418">
        <property type="entry name" value="UFD1_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555:SF15">
        <property type="entry name" value="FUSION DEGRADATION PROTEIN (UFD1), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555">
        <property type="entry name" value="UBIQUITIN FUSION DEGRADATON PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16558">
        <property type="entry name" value="AZUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24503">
        <property type="entry name" value="DUF7590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03152">
        <property type="entry name" value="UFD1_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24842">
        <property type="entry name" value="UFD1_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23580">
        <property type="entry name" value="Znf_XAF1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 1" evidence="4">
        <location>
            <begin position="77"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 2" evidence="7">
        <location>
            <begin position="149"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7590" evidence="6">
        <location>
            <begin position="251"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-protein ligase E3A N-terminal zinc-binding" evidence="5">
        <location>
            <begin position="636"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="374"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="385"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS20171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="748" mass="82325" checksum="0FF69A89BEF2FADC" modified="2011-10-19" version="1">MDGLQLSWSSSLRVAHPARIASKDLQGDKILLPQSALEQLLAASSSSAPGMHSFTAFDSHNPYSVAGRRQFRDNDRQLPHPLMFQLINQKNGNTVYAGIREFSADEGEVALSPHLLDALGICESDIAEVSAGRTEDGARIVVRAKQLPKGEYVRLRPMEAGYDPDDWRPLLERQLRSSYTTLTKGSILTVQGAKGEEFRFLTDRFRPEGDGICVVDTDLEVDIEPLDEEQARETLRQIQAKAQKAPGTANGSSVGHAIDIWKDVDGQVLGGDYVDYELPAWDKSRPLAIELTIQDEREVDLYVSPKSNRQRSRPREDEHIFADFSSPKDGVKRIVIQPGNVELEGAESLLISIHGFVLPDSSSDPTPRRYTLRARAVDTDRPAPNGSTSAPTAPSSDEEQCRNCLQNVPKRTMLLHESFCLRNNIICPECRLVFQKSSPEWSSHWHCPTHPSASGSTPLSKAKHDYIEHTQHTCPACGPSSPFTFPSLPELSRHRTTICPHKPILCSFCHLEVPQEGDPLDPACEAETALTGLTPHERADGARTTDCHLCGAIVRLRDMAAHMAHHELDKLSRPKPIPCRVALCGRTLYGASAKGTTRVGGQGPGNDLGLCSICFAPLWANLHDPEGKALRRRIERKFLTQLMSGCGKKWCGNEYCKTGRKNLGLPPKGEKAAEAMQIVKGLMEGVYDTHREGSVWFCVDEASQKRRKIAEMLAAEGVYELEWCVAAVEAEGGSLERARGVVGGLGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0SA12</accession>
    <name>G0SA12_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="3 6">2.1.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0040620</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = 2-dehydropantoate + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the PanB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="3 6"/>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694469.1">
        <property type="nucleotide sequence ID" value="XM_006694406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SA12"/>
    <dbReference type="STRING" id="759272.G0SA12"/>
    <dbReference type="GeneID" id="18258100"/>
    <dbReference type="KEGG" id="cthr:CTHT_0040620"/>
    <dbReference type="eggNOG" id="KOG2949">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036645_1_0_1"/>
    <dbReference type="OMA" id="VLVWTDM"/>
    <dbReference type="OrthoDB" id="425211at2759"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000003">
        <property type="entry name" value="3-methyl-2-oxobutanoate hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001452">
        <property type="entry name" value="PRK00311.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881:SF0">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000388">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS19584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="264" mass="28206" checksum="7621699D50A767AE" modified="2011-10-19" version="1">MITAHDFPSAHVADAAGMDVVLVGDSLAMVALGMEDTSEVLLEEMLLHCRSVARAVKSAFTIGDLPMGSYEIAPAQALETAIRFIKEGRMQAIKLEGGKEMAPTIEKITTAGIPVLGHVGLTPQRQHAFGGFRVQGKTAASAMQVLEDALAVQKAGCFAVVLEAVPAEVASIITKKLSIPTIGIGAGNGCSGQVLVQVDMTGNFPPGRHLPKFVKKYGDVWSESFRAIETYRDEVKSRAYPAPEHTYPIAEEELKGFEEAVKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>G0SA62</accession>
    <name>G0SA62_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CTHT_0041130</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694519.1">
        <property type="nucleotide sequence ID" value="XM_006694456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SA62"/>
    <dbReference type="STRING" id="759272.G0SA62"/>
    <dbReference type="GeneID" id="18258151"/>
    <dbReference type="KEGG" id="cthr:CTHT_0041130"/>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002664_0_2_1"/>
    <dbReference type="OMA" id="NSADYRP"/>
    <dbReference type="OrthoDB" id="1928777at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12121">
        <property type="entry name" value="MARK_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14077">
        <property type="entry name" value="STKc_Kin1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000333">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="114"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="KA1" evidence="16">
        <location>
            <begin position="804"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="516"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="516"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="621"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="654"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGS19634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="853" mass="95953" checksum="751D6378F4ABE4CD" modified="2011-10-19" version="1">MASAPPAGVDRAELPIRSQSVRTPRRPPTSSRPEPLPRSESSTRAESSRPHRRPSQRSTSTAAPSPRHPQESDMPPPAPPSSATHTYNQADDPGIQRTSKHRYRTVIPAPSGNYAFIKTIGQGSMGKVKLAKKEGTGELVACKIIERVSPDDGRTSKEEREKADAAREDRNAREAAIVSLLHHQYICALRDNLRTRWHWYMLFEYVNGGQMLDYIISHGKLKEKQARKFARQIASAVDYCHRNSIVHRDLKIENILISKTGDIKIIDFGLSNLFSPDENRKLKTYCGSLYFAAPELLQARPYTGPEVDIWSFGVVLFVLVCGKVPFDDQYMPALHQKIKKGHVDYPNWLSSECKHLISRMLVTDPKQRATMHEVMNHPWMVKGYNGPPENYMPYREPLKLPLDDEVIRHMTGFKFGPPEQIREQLTNLILSPKYQAAARRWEKEREQAQSVTKDAEKRRGFGFDFYKRRNSITSKETLTTTSSEGLALGEDILNAYDPLISIYYLVKEKLERERQAQAQQLSAPPAVQQVPASPHQSHAHVPPSPVVRPKEKHSMAEIAPPQPAHTEGSDGRTRHRARSHSEDQVREAVNNSLLTPEMIPQTKKTSGGGGNGPVSLLRRLSTRDRRREPGNPEGRSGTLIQKSVSMRAKSLGHARRESIQARRARREAEAREQQAQNPQSPMHQPPSVREETDAELVNAGVDAGETSGGSHDRLGSSSEDPDLVRPVYLKGIFSVSTTSTKPLPQIRADIKRVLRMLAVEFTEIRGGFSCTYRPSVIVPGDRDVGERRNSFQFSSQHDASRDRERVADGEIKFEIVIVKVPIVSLHGVQFKRVGGDTWQYKTMAGQIVKELRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAE5</accession>
    <name>G0SAE5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP cyclohydrolase II</fullName>
            <ecNumber evidence="3">3.5.4.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0041990</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 2 phosphate + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.25" evidence="3"/>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694602.1">
        <property type="nucleotide sequence ID" value="XM_006694539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAE5"/>
    <dbReference type="STRING" id="759272.G0SAE5"/>
    <dbReference type="GeneID" id="18258237"/>
    <dbReference type="KEGG" id="cthr:CTHT_0041990"/>
    <dbReference type="eggNOG" id="KOG1284">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020273_2_4_1"/>
    <dbReference type="OMA" id="RLPNVEC"/>
    <dbReference type="OrthoDB" id="5569761at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="entry name" value="GTP cyclohydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001591">
        <property type="entry name" value="PRK00393.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00505">
        <property type="entry name" value="ribA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF29">
        <property type="entry name" value="GTP CYCLOHYDROLASE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="RibA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="10">
        <location>
            <begin position="244"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="220"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS19717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="417" mass="44410" checksum="6B0FCFDB461AB9F2" modified="2011-10-19" version="1">MPASTTDSEPIQASGSTTLPSFYSPRRTAVEEQGDVKDADFSVLTASTNGTLAPANGDNTQDGSSSSSSSSSSSSSSSASASASASSASSSAEQLTQPPPSLISPQFTPPSTPGTSTPLPISVPRGVPVDSSLPDNTGGCGSSHPRLLDPLPEVECVVRARIPTTTGAEMFLHLYTNNVDNKEHLAIVFGHNIRSKSLDAPRPGETEMDRLIRGAYTGRLYPGRTTSGLGPGEESTQKEDGPKEEYGPPLVRIHSECYTGETVWSARCDCGEQLDEAARLMSHPDNKAGGIIIYLRQEGRGIGLGEKLKAYNLQDLGNDTVEANLLLRHPADARSYGLATAMLLDLGQKEIRLLTNNPDKIRAVEGPNREIVVRERVPMIPLSWKGKGGFRAPEVEGYLKTKIEKMGHMLDLGSLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAQ9</accession>
    <name>G0SAQ9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative copper resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0043160</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694716.1">
        <property type="nucleotide sequence ID" value="XM_006694653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAQ9"/>
    <dbReference type="STRING" id="759272.G0SAQ9"/>
    <dbReference type="GeneID" id="18258354"/>
    <dbReference type="KEGG" id="cthr:CTHT_0043160"/>
    <dbReference type="eggNOG" id="ENOG502S7CA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022327_1_0_1"/>
    <dbReference type="OMA" id="AHIKCDC"/>
    <dbReference type="OrthoDB" id="5600085at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Copper fist DNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.430.10">
        <property type="entry name" value="Copper fist DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051763">
        <property type="entry name" value="Copper_Homeo_Regul"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001083">
        <property type="entry name" value="Cu_fist_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036395">
        <property type="entry name" value="Cu_fist_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00649">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00617">
        <property type="entry name" value="COPPERFIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM01090">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00412">
        <property type="entry name" value="Cu_FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57879">
        <property type="entry name" value="Zinc domain conserved in yeast copper-regulated transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50073">
        <property type="entry name" value="COPPER_FIST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Copper-fist" evidence="9">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="71"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS19831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="447" mass="47959" checksum="0096A40456F4483D" modified="2011-10-19" version="1">MIINGEKYACEACVRGHRVSNCQHHDRPLQHINKKGRPVSQCAHCRAMRKSRSAHVRCDCGEKTTKCVHLRPPLEGHKGKKDSPSQQLDPVPESGAEAVNASNSPSPTTSSSSSANGSNKSSSKPSSRPRRRASTMSSDGMLSFDANGHHKPTHRHNKAAQKCSPYQLNRVNSLPHGSLKHRSMDDLIGAADCPSRNSSGSGSDEQMQRRVRSEAASPLLDGSSGFSQMNGQLPPLDLSNIKYTPYIPNSADFFGSLSDYEQPLFSAGLSATSVDWNNYEGLDFNSKSTDFSPSSYSQPQSFGGFDFSGPDSIPTLTATASTSGEVSEVEDFLSNPLDDFDAFSTATGTTSGYSISTSQLGLLSSNPSELSSLEFDDFNFMKKASSKFMSATGPLDDPLLTGATAAAPNFSALAALDEDSTFWINDYSGLPLTDSPNDSSMPSFWDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAY3</accession>
    <name>G0SAY3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein SQS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0048220</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SQS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695185.1">
        <property type="nucleotide sequence ID" value="XM_006695122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAY3"/>
    <dbReference type="STRING" id="759272.G0SAY3"/>
    <dbReference type="GeneID" id="18258860"/>
    <dbReference type="KEGG" id="cthr:CTHT_0048220"/>
    <dbReference type="eggNOG" id="KOG0154">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007254_0_0_1"/>
    <dbReference type="OMA" id="QTSQHDH"/>
    <dbReference type="OrthoDB" id="21470at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02646">
        <property type="entry name" value="R3H_G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034082">
        <property type="entry name" value="R3H_G-patch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051189">
        <property type="entry name" value="Splicing_assoc_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14195">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="11">
        <location>
            <begin position="562"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="10">
        <location>
            <begin position="699"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="198"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="246"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="382"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="392"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="414"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS19363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="742" mass="81904" checksum="22277BE1901E9D21" modified="2011-10-19" version="1">MGASLRQSWSRSALIIPALQAPVIHSYTTSFQGACITWSEWAWLEGDAKLRHKPIAFISAGFVEPLKELKELERPESGEVTESVNDNPETNGNIDASAYPNAATPETEVLNRVTVETTVETTIRFIEQPRLNQSAVISKSVTAVGNGSSAAEEVEQVEKCEVEEITTAKETIQTDKEIQSNDGLFVFDLEGDESMLEKLTQAPPPKPPPAEKEKKTSSKPASPRASCGSDSSEEVILFKGRLAAAKGTSKRLDQSSTPEFSTFQKSSQDSKPSAEQKSSNARKTRALVVAPHNRTSQNDTLAFGMSRKKQLKGRRNSRHPPPMEEDSEEDAILADYIENMAANDEDDFFSQQLQALSGYRDLGGDHDSVNFGREDEFGLFKTGDSLGEDSGSEVSGASGTSDVETTDMLNEEKSESEEDESMAEDMDDETLAQLLAKQEEHGMGSDKLLLFNSSAAAKRDKGRQQKQHTTLPSASQVADALDNLEIGEWGAPYLRHPRKRRSKQPPNFNVSDSEVEAALRAAWQRDRERKKERKMAREALRSQGLLGKNADLNDLRVKYPHGMKLDDMKAELVSFLLSSAERLEFPPLDKHARKILHELANKFNITSKSSGSGDQRRPVFYRTKRTVRYASTKVEEATNHVDKAAMRIHRKYFHRVDIRGHKPSKLPSVTGESKARSSYKALILRDGEIVGASVPELGQDNKGRAMLEKMGWTKGMALGAADNKGILEPVAQVVKRSKAGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0SB49</accession>
    <name>G0SB49_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein UsgS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0048890</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
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            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
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                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
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        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
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                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
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            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
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            <strain evidence="17">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2014" name="Sci. Rep." volume="4" first="7322" last="7322">
            <title>Structural insight into substrate recognition by the endoplasmic reticulum folding-sensor enzyme: crystal structure of third thioredoxin-like domain of UDP-glucose:glycoprotein glucosyltransferase.</title>
            <authorList>
                <person name="Zhu T."/>
                <person name="Satoh T."/>
                <person name="Kato K."/>
            </authorList>
            <dbReference type="PubMed" id="25471383"/>
            <dbReference type="DOI" id="10.1038/srep07322"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 671-831</scope>
    </reference>
    <reference evidence="20 21 22" key="3">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="8544" last="8549">
            <title>Interdomain conformational flexibility underpins the activity of UGGT, the eukaryotic glycoprotein secretion checkpoint.</title>
            <authorList>
                <person name="Roversi P."/>
                <person name="Marti L."/>
                <person name="Caputo A.T."/>
                <person name="Alonzi D.S."/>
                <person name="Hill J.C."/>
                <person name="Dent K.C."/>
                <person name="Kumar A."/>
                <person name="Levasseur M.D."/>
                <person name="Lia A."/>
                <person name="Waksman T."/>
                <person name="Basu S."/>
                <person name="Soto Albrecht Y."/>
                <person name="Qian K."/>
                <person name="McIvor J.P."/>
                <person name="Lipp C.B."/>
                <person name="Siliqi D."/>
                <person name="Vasiljevic S."/>
                <person name="Mohammed S."/>
                <person name="Lukacik P."/>
                <person name="Walsh M.A."/>
                <person name="Santino A."/>
                <person name="Zitzmann N."/>
            </authorList>
            <dbReference type="PubMed" id="28739903"/>
            <dbReference type="DOI" id="10.1073/pnas.1703682114"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.78 ANGSTROMS) OF 24-1505 IN COMPLEX WITH CA(2+)</scope>
        <scope>GLYCOSYLATION AT ASN-329; ASN-638; ASN-894 AND ASN-1227</scope>
        <scope>DISULFIDE BONDS</scope>
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    <reference evidence="25 26 27" key="4">
        <citation type="journal article" date="2021" name="Structure" volume="29" first="357" last="370.e9">
            <title>Clamping, bending, and twisting inter-domain motions in the misfold-recognizing portion of UDP-glucose: Glycoprotein glucosyltransferase.</title>
            <authorList>
                <person name="Modenutti C.P."/>
                <person name="Blanco Capurro J.I."/>
                <person name="Ibba R."/>
                <person name="Alonzi D.S."/>
                <person name="Song M.N."/>
                <person name="Vasiljevic S."/>
                <person name="Kumar A."/>
                <person name="Chandran A.V."/>
                <person name="Tax G."/>
                <person name="Marti L."/>
                <person name="Hill J.C."/>
                <person name="Lia A."/>
                <person name="Hensen M."/>
                <person name="Waksman T."/>
                <person name="Rushton J."/>
                <person name="Rubichi S."/>
                <person name="Santino A."/>
                <person name="Marti M.A."/>
                <person name="Zitzmann N."/>
                <person name="Roversi P."/>
            </authorList>
            <dbReference type="PubMed" id="33352114"/>
            <dbReference type="DOI" id="10.1016/j.str.2020.11.017"/>
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        <scope>X-RAY CRYSTALLOGRAPHY (4.11 ANGSTROMS) OF 24-1505 IN COMPLEX WITH CA(2+)</scope>
        <scope>GLYCOSYLATION AT ASN-329; ASN-894 AND ASN-1227</scope>
        <scope>DISULFIDE BONDS</scope>
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    <reference evidence="24 33" key="5">
        <citation type="journal article" date="2022" name="Front. Mol. Biosci." volume="9" first="960248" last="960248">
            <title>Crystal polymorphism in fragment-based lead discovery of ligands of the catalytic domain of UGGT, the glycoprotein folding quality control checkpoint.</title>
            <authorList>
                <person name="Caputo A.T."/>
                <person name="Ibba R."/>
                <person name="Le Cornu J.D."/>
                <person name="Darlot B."/>
                <person name="Hensen M."/>
                <person name="Lipp C.B."/>
                <person name="Marciano G."/>
                <person name="Vasiljevic S."/>
                <person name="Zitzmann N."/>
                <person name="Roversi P."/>
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            <dbReference type="DOI" id="10.3389/fmolb.2022.960248"/>
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        <scope>X-RAY CRYSTALLOGRAPHY (1.19 ANGSTROMS) OF 1187-1473 IN COMPLEX WITH CA(2+) AND UDP-ALPHA-D-GLUCOSE</scope>
        <scope>GLYCOSYLATION AT ASN-1227</scope>
        <scope>DISULFIDE BONDS</scope>
    </reference>
    <reference evidence="28 30" key="6">
        <citation type="submission" date="2022-04" db="PDB data bank">
            <title>A quinolin-8-ol sub-millimolar inhibitor of UGGT, the ER glycoprotein quality control checkpoint.</title>
            <authorList>
                <person name="Caputo A.T."/>
                <person name="Ibba R."/>
                <person name="Le Cornu J.D."/>
                <person name="Darlot B."/>
                <person name="Hensen M."/>
                <person name="Lipp C.B."/>
                <person name="Marciano G."/>
                <person name="Vasiljevic S."/>
                <person name="Roversi P."/>
                <person name="Zitzmann N."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.82 ANGSTROMS) OF 1187-1473 IN COMPLEX WITH CA(2+); UDP AND UDP-ALPHA-D-GLUCOSE</scope>
        <scope>GLYCOSYLATION AT ASN-1227</scope>
        <scope>DISULFIDE BONDS</scope>
    </reference>
    <reference evidence="29 31 32" key="7">
        <citation type="journal article" date="2023" name="IScience" volume="26" first="107919" last="107919">
            <title>A quinolin-8-ol sub-millimolar inhibitor of UGGT, the ER glycoprotein folding quality control checkpoint.</title>
            <authorList>
                <person name="Guay K.P."/>
                <person name="Ibba R."/>
                <person name="Kiappes J.L."/>
                <person name="Vasiljevic S."/>
                <person name="Boni F."/>
                <person name="De Benedictis M."/>
                <person name="Zeni I."/>
                <person name="Le Cornu J.D."/>
                <person name="Hensen M."/>
                <person name="Chandran A.V."/>
                <person name="Kantsadi A.L."/>
                <person name="Caputo A.T."/>
                <person name="Blanco Capurro J.I."/>
                <person name="Bayo Y."/>
                <person name="Hill J.C."/>
                <person name="Hudson K."/>
                <person name="Lia A."/>
                <person name="Brun J."/>
                <person name="Withers S.G."/>
                <person name="Marti M."/>
                <person name="Biasini E."/>
                <person name="Santino A."/>
                <person name="De Rosa M."/>
                <person name="Milani M."/>
                <person name="Modenutti C.P."/>
                <person name="Hebert D.N."/>
                <person name="Zitzmann N."/>
                <person name="Roversi P."/>
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            <dbReference type="DOI" id="10.1016/j.isci.2023.107919"/>
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        <scope>X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) OF 1187-1473 IN COMPLEX WITH CA(2+)</scope>
        <scope>GLYCOSYLATION AT ASN-1227</scope>
        <scope>DISULFIDE BONDS</scope>
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    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695260.1">
        <property type="nucleotide sequence ID" value="XM_006695197.1"/>
    </dbReference>
    <dbReference type="PDB" id="3WZS">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.70 A"/>
        <property type="chains" value="A=671-831"/>
    </dbReference>
    <dbReference type="PDB" id="3WZT">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.40 A"/>
        <property type="chains" value="A/B/C/D/E/F=671-831"/>
    </dbReference>
    <dbReference type="PDB" id="5MU1">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.48 A"/>
        <property type="chains" value="A=24-1505"/>
    </dbReference>
    <dbReference type="PDB" id="5MZO">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.48 A"/>
        <property type="chains" value="A=24-1505"/>
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    <dbReference type="PDB" id="5N2J">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="4.40 A"/>
        <property type="chains" value="A/B=24-1505"/>
    </dbReference>
    <dbReference type="PDB" id="5NV4">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.78 A"/>
        <property type="chains" value="A=24-1505"/>
    </dbReference>
    <dbReference type="PDB" id="6FSN">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.19 A"/>
        <property type="chains" value="A=1187-1473"/>
    </dbReference>
    <dbReference type="PDB" id="6TRF">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="4.11 A"/>
        <property type="chains" value="A=24-1505"/>
    </dbReference>
    <dbReference type="PDB" id="6TRT">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="4.58 A"/>
        <property type="chains" value="A=24-1505"/>
    </dbReference>
    <dbReference type="PDB" id="6TS2">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="5.74 A"/>
        <property type="chains" value="A/B/C/D=24-1505"/>
    </dbReference>
    <dbReference type="PDB" id="6TS8">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="4.60 A"/>
        <property type="chains" value="A/B=28-1409"/>
    </dbReference>
    <dbReference type="PDB" id="7ZHB">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.89 A"/>
        <property type="chains" value="A=1187-1473"/>
    </dbReference>
    <dbReference type="PDB" id="7ZKC">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.77 A"/>
        <property type="chains" value="A=1187-1473"/>
    </dbReference>
    <dbReference type="PDB" id="7ZLE">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.82 A"/>
        <property type="chains" value="A=1187-1473"/>
    </dbReference>
    <dbReference type="PDB" id="7ZLL">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.65 A"/>
        <property type="chains" value="A=1187-1473"/>
    </dbReference>
    <dbReference type="PDB" id="7ZLU">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.05 A"/>
        <property type="chains" value="A/B/C=1187-1473"/>
    </dbReference>
    <dbReference type="PDB" id="7ZXW">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.25 A"/>
        <property type="chains" value="A=1191-1473"/>
    </dbReference>
    <dbReference type="PDBsum" id="3WZS"/>
    <dbReference type="PDBsum" id="3WZT"/>
    <dbReference type="PDBsum" id="5MU1"/>
    <dbReference type="PDBsum" id="5MZO"/>
    <dbReference type="PDBsum" id="5N2J"/>
    <dbReference type="PDBsum" id="5NV4"/>
    <dbReference type="PDBsum" id="6FSN"/>
    <dbReference type="PDBsum" id="6TRF"/>
    <dbReference type="PDBsum" id="6TRT"/>
    <dbReference type="PDBsum" id="6TS2"/>
    <dbReference type="SMR" id="G0SB58"/>
    <dbReference type="STRING" id="759272.G0SB58"/>
    <dbReference type="GeneID" id="18258937"/>
    <dbReference type="KEGG" id="cthr:CTHT_0048990"/>
    <dbReference type="eggNOG" id="KOG1879">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002668_1_0_1"/>
    <dbReference type="OMA" id="RQTKTRF"/>
    <dbReference type="OrthoDB" id="27683at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="EvolutionaryTrace" id="G0SB58"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003980">
        <property type="term" value="F:UDP-glucose:glycoprotein glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06432">
        <property type="entry name" value="GT8_HUGT1_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000065">
        <property type="entry name" value="UDP-glucose:glycoprotein glucosyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040497">
        <property type="entry name" value="Glyco_transf_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009448">
        <property type="entry name" value="UDP-g_GGtrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040693">
        <property type="entry name" value="UGGT_TRXL_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040694">
        <property type="entry name" value="UGGT_TRXL_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040692">
        <property type="entry name" value="UGGT_TRXL_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040525">
        <property type="entry name" value="UGGT_TRXL_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226">
        <property type="entry name" value="UDP-GLUCOSE GLYCOPROTEIN:GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226:SF0">
        <property type="entry name" value="UDP-GLUCOSE:GLYCOPROTEIN GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18404">
        <property type="entry name" value="Glyco_transf_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18400">
        <property type="entry name" value="Thioredoxin_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18401">
        <property type="entry name" value="Thioredoxin_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18402">
        <property type="entry name" value="Thioredoxin_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18403">
        <property type="entry name" value="Thioredoxin_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06427">
        <property type="entry name" value="UDP-g_GGTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="18 19 20" id="KW-0002">3D-structure</keyword>
    <keyword evidence="20 21 22" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="20 21 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="30" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408982" evidence="10">
        <location>
            <begin position="28"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="11">
        <location>
            <begin position="41"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="12">
        <location>
            <begin position="278"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="13">
        <location>
            <begin position="416"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="UDP-glucose:glycoprotein glucosyltransferase thioredoxin-like" evidence="14">
        <location>
            <begin position="671"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="domain" description="Glucosyltransferase 24 catalytic" evidence="15">
        <location>
            <begin position="1200"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1140"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1471"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1471"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1500"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="binding site" evidence="30">
        <location>
            <position position="1207"/>
        </location>
        <ligand>
            <name>UDP</name>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24 28 33">
        <location>
            <position position="1207"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="30">
        <location>
            <position position="1211"/>
        </location>
        <ligand>
            <name>UDP</name>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24 28 33">
        <location>
            <position position="1211"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="28">
        <location>
            <position position="1276"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24 28">
        <location>
            <position position="1280"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24 33">
        <location>
            <position position="1283"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20 21 22">
        <location>
            <position position="1302"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24 28 33">
        <location>
            <position position="1302"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="1304"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24 28 33">
        <location>
            <position position="1396"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20 21 22">
        <location>
            <position position="1435"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24 33">
        <location>
            <position position="1435"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="29">
        <location>
            <position position="1436"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="30">
        <location>
            <position position="1438"/>
        </location>
        <ligand>
            <name>UDP</name>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24 28 33">
        <location>
            <position position="1438"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="30">
        <location>
            <position position="1446"/>
        </location>
        <ligand>
            <name>UDP</name>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24 28 33">
        <location>
            <position position="1446"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="22 23 26">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="21 22 23">
        <location>
            <position position="638"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="23 25 26">
        <location>
            <position position="894"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="23 24 27">
        <location>
            <position position="1227"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20 21 22">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20 21 22">
        <location>
            <begin position="1330"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20 21 22">
        <location>
            <begin position="1419"/>
            <end position="1437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGS19438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PDB" id="3WZS"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="19">
        <source>
            <dbReference type="PDB" id="3WZT"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PDB" id="5MU1"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="21">
        <source>
            <dbReference type="PDB" id="5MZO"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="22">
        <source>
            <dbReference type="PDB" id="5N2J"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="23">
        <source>
            <dbReference type="PDB" id="5NV4"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="24">
        <source>
            <dbReference type="PDB" id="6FSN"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="25">
        <source>
            <dbReference type="PDB" id="6TRF"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="26">
        <source>
            <dbReference type="PDB" id="6TRT"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="27">
        <source>
            <dbReference type="PDB" id="6TS2"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="28">
        <source>
            <dbReference type="PDB" id="7ZHB"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="29">
        <source>
            <dbReference type="PDB" id="7ZKC"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="30">
        <source>
            <dbReference type="PDB" id="7ZLE"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="31">
        <source>
            <dbReference type="PDB" id="7ZLL"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="32">
        <source>
            <dbReference type="PDB" id="7ZLU"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="33">
        <source>
            <dbReference type="PDB" id="7ZXW"/>
        </source>
    </evidence>
    <sequence length="1509" mass="170912" checksum="31DB8F521CBC3468" modified="2011-10-19" version="1">MMRLSQLPWGLAALLAAACLPSLQVAASPSINVALKAAFPSPPYLVELLETAASDNTTIYYSLLDRIAKGHFAEATTDKALYEKFLEVLRDDGHMDPEALSAFKLALSLRTATPRVEAHYQYYTATVEPSLSGTQEGCDQWFLIDGEQYCSPTLDTSHGKVKGEDQLRTLPFDRKFGVGSRDVILYADITSKSFAPFHEVAMDLAKKGKASYRVRYRRSPSHSRESLSVNGYGVELVLKRTDYIVIDDRDTGAAAKPAEENDQKPLVGHETVLDDGEEIADIKPLEKSELAALGMKAASFVMQSEKPFEALLKLTQDFPKYSNSLGSQNVSAEFEAEHRGNREVFLPEGSNVLWLNGLHLIDRQIQPFGLVDLLTRERKLIKSVLDLGLTGQQAVDLLGHAEVAHAKSGDDEPRRFDWRDDIEEGQVIIWLNNLEKDKRYKSFSPSIWVLIHHFGHGLPQIRRDVFNLVVPVDLTKADDVKIVVEGLLSFVKRLIPVRFGFVPLTPTGQAIDQAKVVYYLLENYGLAAATAYLEKSYEEQSTGQPNERIFNEVIKDKSLRPDGVELSFKDIFISEKHEKQIHLSKHWVERLRAGGDVPTVFFDGFPIPREDNWLRVMNHRLMQDLQALQQAGYFGMLNESMWLPGFFLEKALSRRNTLIFPEDKNELTVLNVNKIYIENHDLMSKVPVIEASKESTRDDWAALTVVADLDDIEGQELVYYALRFRKSNDGVRLDIVHNPKDTSRSPSVLAQRLKSREDKLLDFTRFLDLETALETGEFEPDVAYDASLANFLASSNMKAGDNFVILNGRVLGPITSADDFKKEDFEVFLQAERRTRILPVYKALEDLGLDDKVSGPLSAAKLTSVTALSTISDLPQGIFDNAPTVRTTLFKQWNSTYTSFEVGDASTATIFFVAVINPASEIGQRWVAVLKVLSELEGVHLRVFLNPTVMIEELPVKRFYRYVLSSSPSFDESGKVKALSARFTGVPRETLLVVGMDVPPAWLVTSKVAVDDLDNLRIKDIKAKRGTEHVEAIYELEHILIEGHSREIPGAHAPRGVQLVLETENNPHFADTIIMANLGYFQFKANPGVYNIRLKEGRSSEIFTLESVGAKGWGPIPGDDNTEVVLMDFQGTTLYPRLRRKPGMEEEDVLEPSTKSGEESGSGARNLVSRGIKFAEGLLGRGNKAAEATKSVSKTEHAEINIFSVASGHLYERMLNIMMASVMHHTNHTVKFWFIEQFLSPSFKDFIPHMAAEYGFKYEMVTYKWPHWLRQQKEKQREIWGYKILFLDVLFPLSLDKVIFVDADQIVRTDMYDLVEHPLDGAPYGFAPMCDSRVEMEGYRFWKTGYWANYLKGKPYHISALYVVDLQRFRELAAGDRLRQQYHALSADPNSLANLDQDLPNHMQFTIPIATLPQEWLWCETWCSDETLKDARTIDLCNNPMTKEPKLDRARRQVPEWTKYDEEIAELARRVREEKPKKKEEEKVQKNPKSRRLDGDEEEVKTVREKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBJ0</accession>
    <name>G0SBJ0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">UDP-glucose pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0053750</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a central role as a glucosyl donor in cellular metabolic pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>alpha-D-glucose 1-phosphate + UTP + H(+) = UDP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695711.1">
        <property type="nucleotide sequence ID" value="XM_006695648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBJ0"/>
    <dbReference type="SMR" id="G0SBJ0"/>
    <dbReference type="STRING" id="759272.G0SBJ0"/>
    <dbReference type="GeneID" id="18259413"/>
    <dbReference type="KEGG" id="cthr:CTHT_0053750"/>
    <dbReference type="eggNOG" id="KOG2638">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023632_3_0_1"/>
    <dbReference type="OMA" id="KEYCFLS"/>
    <dbReference type="OrthoDB" id="932129at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00897">
        <property type="entry name" value="UGPase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000001">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000002">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016267">
        <property type="entry name" value="UDPGP_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43511">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS18766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="602" mass="66937" checksum="7570468485DA789F" modified="2011-10-19" version="1">MATRTLPTHLKPHDSSSGDDIEFAKRHHGKTRSHMHSQGPGGRVPGHWEDKSDLARIRAARKRGWQEIGRINGLQGTGRATVDVAKGLAACIPVVVTKPACRAGIAERNATRTPWAFENTSTNIAAAQMRNALTNLAETVKDPEQKKRFESEMDNFFQLFRRYLNDKAKGNEVNWDRIAPPAKDQVIEYDDLPAVESPEFLSKLAVLKLNGGLGTSMGCVGPKSVIEVRDGMTFLDMTVRQVEHLNRTYGANVPIVLMNSFNTDEDTAAIIKKYEGHGVDILTFNQSRYPRIYKDSLLPVPKSFDSPLEGWYPPGHGDVFESLYNSGILDKLLDRGIEIIFLSNADNLGAVVDLRILQHMVESKAEYIMELTNKTKADVKGGTIIDYEGSVRLLEIAQVPKEHVNEFKSIKKFKYFNTNNIWMNLRAIKRVVENDELEMEIIPNAKTIPGDKAGESDINILQLETAVGAAIKHFRGAHGVNVPRRRFLPVKTCSDLMLVKSDLYTVKHGQLHMNAQRFGDAPLIKLGSHFKKVSDFQKRIPSIPKIIELDHLTITGAVNLGRGVTLKGTVIIVATEGQTIDIPPGSILENVVVQGSLRLLEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBK7</accession>
    <name>G0SBK7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prefoldin subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0053930</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695728.1">
        <property type="nucleotide sequence ID" value="XM_006695665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBK7"/>
    <dbReference type="STRING" id="759272.G0SBK7"/>
    <dbReference type="GeneID" id="18259431"/>
    <dbReference type="KEGG" id="cthr:CTHT_0053930"/>
    <dbReference type="eggNOG" id="KOG4098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113004_1_0_1"/>
    <dbReference type="OMA" id="CFKMIGG"/>
    <dbReference type="OrthoDB" id="29646at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23163">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000002">
        <property type="entry name" value="Prefoldin subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027235">
        <property type="entry name" value="PFD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13303">
        <property type="entry name" value="PREFOLDIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS18783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="14886" checksum="41EE789D8E28BBC4" modified="2011-10-19" version="1">MATQSAAAKRQQDLQLQYTTYKNTLQQIAQKIGDVEQEAEEHKLVLETLEPLPGDRKCFRMINGVLVERTVRDVIPALRTNAEGLKKVLEDLVKQYKAKQDELEQWKVVSVNNYPIKGTSVAKREQISYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBZ5</accession>
    <name>G0SBZ5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zonadhesin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0055340</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695866.1">
        <property type="nucleotide sequence ID" value="XM_006695803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBZ5"/>
    <dbReference type="GeneID" id="18259572"/>
    <dbReference type="KEGG" id="cthr:CTHT_0055340"/>
    <dbReference type="eggNOG" id="ENOG502SD4W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005137_1_0_1"/>
    <dbReference type="OMA" id="TPYRRMA"/>
    <dbReference type="OrthoDB" id="5428901at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF3">
        <property type="entry name" value="SPRAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="653"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="700"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="723"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="774"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="912"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="955"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1020"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1051"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS18921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1172" mass="125943" checksum="CDF1375D3FEC5716" modified="2011-10-19" version="1">MPPPSLFAARDDRNTGAAYEYDIQATEDRHEDDEPTNSSEEPRHAKDTPVWQSINKPNYKPTALRWPFIGCIIVLLLVAMTLVIVADKKMPDSDADAVILGLNPNRTQLARLRIRDDEPTITISETSGAAGPQTFTIGAVPERATDALDQNSISTDTPLDEDYELIPISTFVSTFTTWLSLEPSSLPTLEEVVTEWQTLPVATYETTVTTLITSSGTRTDLDGPVVTTIYSPITNGTIVSSIPVSTRTTTIPPPAPTVIETTVITTIISSSEVAVTKTIIVTLDPEVVLKPSVGSITITYYSSVPRRNNGAAGAVEHQITEGPEQVPQPPVITGVEEVGGNVVTIVKSQEVSVFVVPEEDEVRTETVDAQVRIGVTKEDDSTIANVVVVTPSPVQIVPAVVTNNGVVLTVNPGGSFTRTVVNNVGGTATSQVIVTTPAGTNPITYTVVRDQGGTLVAEAVVITPTAADQPITYTAYSVNGGTPVTQFLVETPPPAFQPVTLTISTIIGGTPVVTTTQQLPVTIIEIINGTPVTRVSTLPVTSYTTTIGGTPTITTIVTTPTDTSPITMTLTSISEGTFRTYTTTISATTYLTTISGTLRTVTSTLPPITSFTTLPKSLYTFTSTLSVSSTPPTSTPSSIPSRVRVYSWTESDIFIGTFLPALLGVGLVIPLRILDLNAKLYQPWQALAKHGGGPGSQTLLLQYSGVLGVVWTPIVGLFSGKAVVPFLTTLMVACASFFVPLATEAVGLKLHGECYLNTASSRCGPALGVSRGPAYALVGLLAAVVVLVGVVGWLVSRWVTGVAANPWNVAGVASLAGSRLVRVRENGEHDMRRAMAEKIYGLASFRGEHGKEEYGIVLLDEAGRRLNDDREGETLVDDRDGDDPGAAMHKEKGGEGIAGLTSKQLPFMTLRYPWRIVFVLFQLAVLIFIIYYHAYYRGGIRDGGRLWLFLNANRFGVRFVSAIIGVIIAFCWQSFFLSVSIMAPYQLMATKTQPAIHSILFSPNTNPFSGIWSAIKHRHAFLGAVSGAAILSEFLPVILSNVPFNLAQTQTAATVCAVLSCVFLILMISTLVWSFFIRYPPMPVDPRCIAGLLYYVSRSRMVVEERDFQGLSRLDRQERELRIRELGRRYFYGVLAGSSERRLGVDCDAGTLGEGMHVSTEYKGAGALSRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0SC23</accession>
    <name>G0SC23_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PLC-like phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0055630</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695894.1">
        <property type="nucleotide sequence ID" value="XM_006695831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SC23"/>
    <dbReference type="GeneID" id="18259601"/>
    <dbReference type="KEGG" id="cthr:CTHT_0055630"/>
    <dbReference type="eggNOG" id="KOG4306">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024751_0_0_1"/>
    <dbReference type="OMA" id="PKQHQCY"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF146">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS18949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="487" mass="53629" checksum="DE64BBEA564B27EF" modified="2011-10-19" version="1">MPSKGVQVFAYIAVPDCKIELSVPGETVTFSEQRKFWSRSLEVESSKIRSLLDKRGRFTFKIFHKGTQLTEQWIDVNALTGNASGGTLEKISKTPSLVVRDRGLIISYGLYEAGKGHKASEIHVLPNKHQCYITISPDYASWIGRLAPVGSPAENKPFHRLVLPAAHDVGMNSMESTEALLKKVGGAIVSTLIGDRLPKQREAISQLANTLSKDAISKIAPNIVYSLAITQKDSLETMLRIGARYFEFRPARLHRAVISCGALPDKLYFQHGAIPGMAYDEFLKGVLAFLRANPTEIVVVQLRWDGVPDECARPSDKEKKEYLEKALKDPAGGNGEIVAGGLDDMKKKSIAQLRKDKKRLIMLDMVDSLSTYTDEGNATLNGDSMVQALPKVLTPENQKGKAFVNIQCQATASNIPKAVVHSIIEASVTNSLLLATKGICDSKMLPWCRDNVLQVCLLDILVVIMNDWIDGATAHVCFELSKQRLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0SC63</accession>
    <name>G0SC63_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0056080</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695934.1">
        <property type="nucleotide sequence ID" value="XM_006695871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SC63"/>
    <dbReference type="STRING" id="759272.G0SC63"/>
    <dbReference type="GeneID" id="18259646"/>
    <dbReference type="KEGG" id="cthr:CTHT_0056080"/>
    <dbReference type="eggNOG" id="ENOG502SVCF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024934_2_1_1"/>
    <dbReference type="OMA" id="MVFNWAV"/>
    <dbReference type="OrthoDB" id="5350673at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS18989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="298" mass="34008" checksum="364558722A19F61D" modified="2011-10-19" version="1">MEHMELLVRFKFEEHAPELNVEMHEFSSNLLFKCALEAPYLMHQILAVSARRLAVLEPHRADYFHQHAIQLQTKAVSIYNGTAAKAQIDQTNCSALLLFCSLLGRHLFADLLARRDADFDIFLTHFLEFLSISRGLKAMSVSAWDLLLQSDIRHLVVWALDISQSTPEGTHCSELQRLVKETTTLNPLSKEACMRAIAFLQVGFDSLLGADERNQKYLMVFMWPAAVPHEFTELLAQKRPEAIAIMGYWALLLDCSKALWHIADSGSYLLRSISQYLGPRWAHWLSWPLSMLDAKEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCA6</accession>
    <name>G0SCA6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Oligosaccharyltransferase subunit-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0056540</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695977.1">
        <property type="nucleotide sequence ID" value="XM_006695914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCA6"/>
    <dbReference type="STRING" id="759272.G0SCA6"/>
    <dbReference type="GeneID" id="18259692"/>
    <dbReference type="KEGG" id="cthr:CTHT_0056540"/>
    <dbReference type="eggNOG" id="KOG2447">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051361_0_0_1"/>
    <dbReference type="OMA" id="VFFMYYT"/>
    <dbReference type="OrthoDB" id="432292at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056790">
        <property type="entry name" value="Ribophorin_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008814">
        <property type="entry name" value="Swp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640">
        <property type="entry name" value="RIBOPHORIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25147">
        <property type="entry name" value="Ribophorin_II_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044203227" evidence="8">
        <location>
            <begin position="22"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Ribophorin II C-terminal" evidence="9">
        <location>
            <begin position="175"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS19032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="284" mass="30433" checksum="21458394B661DE80" modified="2011-10-19" version="1">MRLTHSVASALLLLCAGAAQAATSWGFDEGVIQVVPKKAGEVIKERTPLAKPVTLGATDTLKLSLTAKDNGIGKRPHQAFLLLQESNLGVEAPFPLTVKESGKATVQITQKDLPVQLLAAEEPLKASIVLASFGSAQGYNGQVFEIKVELDPNLPPPTREAPVRYGKKPLIFHKFNPDPKSPPKVVSIFFALAVIACLPVLLISWLFLGANIKHLPKALSAAPVSHAVFFGSIVAMEGVFFMYYTSWNLFQTLPVIAAVAVVTVLSGTKALGEVQSRRLAGDRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0SD50</accession>
    <name>G0SD50_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0050820</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695425.1">
        <property type="nucleotide sequence ID" value="XM_006695362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SD50"/>
    <dbReference type="GeneID" id="18259120"/>
    <dbReference type="KEGG" id="cthr:CTHT_0050820"/>
    <dbReference type="eggNOG" id="ENOG502T0BR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015774_1_0_1"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF9">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="432"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="529"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="216"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="300"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="333"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="449"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="556"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS18480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="565" mass="60895" checksum="8179E8DC27F6C8B9" modified="2011-10-19" version="1">MQHMAICWAACFLSDTGHVERPFAQSHKDRVIQLLNRQLLVSASDEMIAAVLQLIVVEWLWGSAELLQTHRNCLQQLILTRGGLNTLGLHGLISKHAVTTDVAIALSFENEPTLRGSPVFDFDDNTQAPFRVTQNTPFDFSSIAFAQWAPAHPARIAEPVASILEDIRTLLKAVHKSLENPYDLKELQRVRSTALFVQERLNKAPTDIITGHRPSATLSPGTPSPGSTNIPSPSLQPHRTSASRSRTPQPAAPPLTQQPLPGAPGISLTAPQPIRQPILPGPQQPDWRGPDFSQTLSPHLQPPSPLPSISPVPSPILSSTSVSSGIAVVSPSPSSPAPPPPLSPSPGPTTPSSVSNGPTEQDYIYQVVRQAALLYTKAIIARKPFSQVVTAEEFQNLWTTAWHVPLSTWRSLLGVFNWILLPISCRGKQAFGSTPAGRDVNSEGAVDPSLSGQGQSQAQGQEGSKRKGKEKSQGVGISTPHDRYVKGMLNLTLLQMAMENWAIAKKIMEGEIALQRWLANKSEAESFMSGAASGQGWEGAGEDSSVLQQAGMAVSGEDKGKRRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0SD74</accession>
    <name>G0SD74_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Chromatin assembly factor 1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0059200</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696239.1">
        <property type="nucleotide sequence ID" value="XM_006696176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SD74"/>
    <dbReference type="STRING" id="759272.G0SD74"/>
    <dbReference type="GeneID" id="18259958"/>
    <dbReference type="KEGG" id="cthr:CTHT_0059200"/>
    <dbReference type="eggNOG" id="KOG1009">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010127_3_1_1"/>
    <dbReference type="OMA" id="CIVSNLH"/>
    <dbReference type="OrthoDB" id="71227at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000461">
        <property type="entry name" value="Chromatin assembly factor 1 subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045145">
        <property type="entry name" value="PTHR15271"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271:SF4">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="11">
        <location>
            <begin position="8"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="62"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="127"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="162"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="11">
        <location>
            <begin position="306"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="203"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="417"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="569"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="655"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="242"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="441"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="618"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="685"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS19294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="728" mass="77136" checksum="4B992347459415E2" modified="2011-10-19" version="1">MKATPLIVNWHHDNNNPYPIYSAHFEPGGKGRLATAAGDNNVRLWKIEENGDGRKVEYLATLSKHTQAVNVVRWAPKGELLASAGDDGNVILWVPSETHHPTFGSDGLDDKETWRTKHMCRSLGTEIYDLAWSPDAQFFIIGSMDNVARIYNAGTGTLVRQIAEHSHYVQGVAWDPMNEYIATQSSDRSVHIYSLKTKDGQYTLYSHDDKPPKVASHVKADLPPRRISQSPAPDSGHRALDSVPGVAVGSPVPSAPGTPQSMPLPMNPPSMISHSRRSSFSSRRSASPAPSMPLPAVMPIEASPKPHLNTSTLGMKNANLYANETLTSFFRRLTFTPDGSLLLTPAGQYQTQHQTAEGKTSSEIINTVYIYSRGGINKPPIAHLPGSKKPSVAVRCSPVIYTLRQSPPKTQYITIDTSSAEEGVPSLPEPISKPEPTSSMDPPPPPPPPPPPADGSTAADKGLSVDTNAQSAGPKSQFGLPYRMVYAVATQDTVFIYDTQQNTPIAVVSNLHCATFTDLTWSSDGLTLLISSSDGFCSTVSFAPGELGTQYTGEIGPPRGPLLAGSNHNTPTATPTSLFAPPSPFPNGSMHRHRDSGSLTAPSPPITAFVNPRAASPARSNSGSSQAPVLSNPPLVGGQVPSIAAANSGKVIGVPVATPPETPKTSLTTTAVAAPPPTSAPSSGTKREGVEGAAGEKDGAQQQSKRRRIAPTLVSGLDGQPVSGEKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0SD80</accession>
    <name>G0SD80_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0059260</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endomembrane system</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696245.1">
        <property type="nucleotide sequence ID" value="XM_006696182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SD80"/>
    <dbReference type="STRING" id="759272.G0SD80"/>
    <dbReference type="GeneID" id="18259964"/>
    <dbReference type="KEGG" id="cthr:CTHT_0059260"/>
    <dbReference type="eggNOG" id="KOG0724">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037236_1_0_1"/>
    <dbReference type="OMA" id="RYIRHAR"/>
    <dbReference type="OrthoDB" id="413400at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052606">
        <property type="entry name" value="DnaJ_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44653">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44653:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409485" evidence="8">
        <location>
            <begin position="20"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="9">
        <location>
            <begin position="37"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="217"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="369"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="408"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS19300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="439" mass="49168" checksum="C842303028B42B26" modified="2011-10-19" version="1">MKLSTFALGLLALFTPLNREIFRVRDEIIANEGPDVTFYDFLGVKRSATLEEINKAYKKKSRELHPDKVRQQLTAKRLKESKDKAKKKGSKPGVHVAKSPSQAEIRAAIKRAEQRQARLSIVADVLRGPLRDRYDYFLDYGFPTWKGTEYYYTRYRPGLGTALTGVFLMFGGAAHYLALYMSWKRQREFVERYIRFARVTAWGDNLGINIPGIDGQPVASQAAAPQPQQTVYQDEEGRPVPMNRKMRRMQERESRKEANKEERGSGRRAKRAQKASPAASGTATPQVRGQGAGPVGPKKRVVAENGKVLVVDSMGNVYLEEEDEDGNVAEYLLDPNELPQPTIKDTAVVRLPLWVYRITVGRLLSKRSPIESEEQAEEAAPEAAENDGEDSEPGRPTPSSGSAEDFEMLEKSVDELGRAKASGNNPKGSKVTKRKNKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDC6</accession>
    <name>G0SDC6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0051300</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695472.1">
        <property type="nucleotide sequence ID" value="XM_006695409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDC6"/>
    <dbReference type="GeneID" id="18259168"/>
    <dbReference type="KEGG" id="cthr:CTHT_0051300"/>
    <dbReference type="eggNOG" id="ENOG502QSXK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011027_0_1_1"/>
    <dbReference type="OMA" id="KFNRVVM"/>
    <dbReference type="OrthoDB" id="1612078at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021102">
        <property type="entry name" value="PNGase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056948">
        <property type="entry name" value="PNGaseA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31104">
        <property type="entry name" value="PEPTIDE-N4-(N-ACETYL-BETA-GLUCOSAMINYL)ASPARAGINE AMIDASE A PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25156">
        <property type="entry name" value="PNGase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12222">
        <property type="entry name" value="PNGaseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A N-terminal" evidence="2">
        <location>
            <begin position="21"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS18527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="613" mass="67958" checksum="707210B1E70C4159" modified="2011-10-19" version="1">MPDGPAESDGSTRHAKDYSPELCTVLLMRHDFAWSYGQPYIGNYTPPDCEFNRVVLNFSVVSHGRQYDRLALMYFGNTEVSQPTVPPGISWIYLKDMTEYMYFWKSPQKIIFDLGNLINEKYTGIFNTTLTAIFYKADVDADQGRPSDLIIPISARRSAKNEVSHFTLPAENATNTIILPRNVRRAVFSVSANGQTAGEEFWWANVLQSTVDTFNETAGPYPGYSPFREVQVLIDGQLAGVQWPFPVIFTGGVVPSLHRPIVGIHAFDLREHQIDITPFLPILCDGNPHTFTIRVAGIDDSSGSGHLTETVNDSWYVTGKIFLWLDEDTSSITTGSAPVILEDPPTIAISHKVTTSANGTNETLTYETAVWRHLRISTPLLKTQHTSSPATWIQELRYRNSGGLTAFGYDQVNDLVISGNDLALSDLPGQSDKGDQDKVYYQASYTYPLFANSTFSISSQGNLSIWAYVRQGKSYVVRGASVFATGLEAFPATRGKISLLETSKEGEGHFQQSGDGIESSGWGSSKQVFWFGIQGQYGDKEEELYFRDVEAVNGTVVRDVRRLGGQDFQPTLTSEDNGSQVSDPTGDQVEAQRSTVFARIARPVSLKRSNWSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDP0</accession>
    <name>G0SDP0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylserine decarboxylase proenzyme 2</fullName>
            <ecNumber evidence="12">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 2 beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 2 alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="12" type="primary">PSD2</name>
        <name evidence="16" type="ORF">CTHT_0052460</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="12">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit. Interacts with pstB2. This interaction may be a means to structurally tether the donor membrane (ER) harboring PstB2 to acceptor membranes (Golgi/endosomes) harboring PSD2 during PtdSer transport to the site of PtdEtn synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Golgi apparatus membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Endosome membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The C2 domains have an essential, but non-catalytic function. They may facilitate interactions with other proteins and are required for lipid transport function.</text>
    </comment>
    <comment type="PTM">
        <text evidence="12">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="12"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695586.1">
        <property type="nucleotide sequence ID" value="XM_006695523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDP0"/>
    <dbReference type="STRING" id="759272.G0SDP0"/>
    <dbReference type="GeneID" id="18259284"/>
    <dbReference type="KEGG" id="cthr:CTHT_0052460"/>
    <dbReference type="eggNOG" id="KOG2419">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002661_0_0_1"/>
    <dbReference type="OMA" id="TCASRDW"/>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="C2_PSD"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="C2A_Synaptotagmin-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Phosphatidylserine decarboxylase proenzyme 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphatidylserine decarboxylase proenzyme 2"/>
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        <property type="entry name" value="Phosphatidylserine decarboxylase proenzyme 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PS_decarb_PSD_B_type2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="C2_dom"/>
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        <property type="entry name" value="C2_domain_sf"/>
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        <property type="entry name" value="EF-hand-dom_pair"/>
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        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
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        <property type="entry name" value="EF_hand_dom"/>
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        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
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        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033179">
        <property type="entry name" value="PSD_type2_pro"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF17">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="12" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023458332" description="Phosphatidylserine decarboxylase 2 beta chain" evidence="12">
        <location>
            <begin position="1"/>
            <end position="1014"/>
        </location>
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            <begin position="1015"/>
            <end position="1113"/>
        </location>
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            <begin position="26"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="273"/>
            <end position="394"/>
        </location>
    </feature>
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        <location>
            <begin position="537"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="194"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="422"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="623"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1053"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="422"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1062"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="869"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="928"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="1015"/>
        </location>
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    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="12">
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            <position position="1015"/>
        </location>
    </feature>
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            <begin position="1014"/>
            <end position="1015"/>
        </location>
    </feature>
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            <position position="1015"/>
        </location>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGS18641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1113" mass="123474" checksum="428E91159E0F553D" modified="2011-10-19" version="1">MVRILPSRLKPGNSNGSGANSNANSRSASPLRKDSPIPESQGLALNVSILRARNLAAKDRTGTSDPYLVLTLGDSKHVTHSVPKTLCPEWNEQCQLPITGVQSLLLDVCCWDKDRFGKDYLGEFDLALEEIFTDEKAEQPPTWYPLKSKKPGKKTSVVSGEVQLQFTLVDTTNKNATNEQIFEKFSLITGAAAAAADASRNPTPSRTPILSPTRKGKSPSPSPSLGEREADDNDDDEEDEVDEDETPEDEDSSKLETAEKRKRRLRIKGLKRKKRENPYEFTNSDSDVVGIIFLEISNIVDLPPESNLTKTSFDMDPFVIASLGKKTYRTKTIRHNLNPVFNEKMIFQVLAHEQSYSFLFTVVDHDKYSGNDFIASVHFPIKELIEKAPKADPETGLYSLRELPDSPAAPVQRPRFMRLGLSRTSSSQSLSKLGRAAVTKNVSSTTITPSASPSPAPSTPQPEGLPEGAPSTAYLNPGDNTVASITAPAGETSQPDSEDPDFLTYTLPLKMKNQEKWEDKHSPKLTIRAKYMPYPALRQQFWRAMLKQYDADESGMISKVELTTMLDTLGSTLRDSTIDSFFQRFPHKAGDNEDAEDLTMDEAVICLEDQLMARSRPQKKILAGFDTPADGGQATPSESQISDGILPVPELSTPGDEGELLGRDDLNASSTEEHVVEIRECPICHQPRMNKRKDADIITHIATCASQDWRQVNNLMMGGFVTSSQAQRKWYTKVITKVSYGGYKIGANSANILVQDRITGQIVEEKMSVYVRLGIRLLYKGLKANNMEKKQIRKLLKSLSIKQGKKYDDPASKAEIPKFIAFHGLDLSEVLLPLEEFKNFNEFFYRALKPGSRPCSAPDNPRIVVSPADCRTVVFNRVEHATKIWIKGREFSIKRLLGDAYPEDVSRYENGGALGIFRLAPQDYHRFHIPVDGILGKPKTIAGEYYTVNPMAIRSALDVYGENVRVLVPIDSNEFGRVMVICVGAMMVGSTVILRNEGEVVRRGEELGYFKFGGSTIVMLFEPGKMVWDSDLVENSMEPLETLIRAGMSVGHAPNEPQWTPDMRKDDAQITEVDRVDAKRRIQGQVSESAEDSGSGLDSPPELQVQVHPPPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDP3</accession>
    <name>G0SDP3_CHATD</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0052490</name>
    </gene>
    <organism evidence="3">
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        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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            <taxon>Thermochaetoides</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EGS18644.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006695526.1"/>
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    <dbReference type="GeneID" id="18259287"/>
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    <dbReference type="HOGENOM" id="CLU_2497695_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="86" mass="9097" checksum="5A17B35DB7C57178" modified="2011-10-19" version="1">MIDSTAAAPSVGGTRPFRGTLPRPAMACHAKKGTPEAPASRRANIAQHGPQLVPGICDSFDGRRWNEDRDSQDRGNHSLMGSQGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDT9</accession>
    <name>G0SDT9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gal4-like Zn(II)2Cys6 binuclear cluster DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0052970</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
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            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006695572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDT9"/>
    <dbReference type="GeneID" id="18259335"/>
    <dbReference type="KEGG" id="cthr:CTHT_0052970"/>
    <dbReference type="eggNOG" id="ENOG502SAWI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011074_1_0_1"/>
    <dbReference type="OMA" id="SMENILH"/>
    <dbReference type="OrthoDB" id="4150467at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="523"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="269"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="361"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="416"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="375"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="427"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="468"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS18690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="629" mass="66844" checksum="99953A34F10014AC" modified="2011-10-19" version="1">MSTATHNGVGPVPGLESGSISPRTPALPKTVQFILVFKDNTHRARLPLRVSIWPHDSTDSIITTVKNFYGIYSGPGFSKGVSFEDEKGNILIARYENFTDGMMVFVRIIDQPIEPELYSPTSGPMYGIDPLSKPSESDRARTSRLRSPSPNGSGRGRRSTPAETNSTNGNSKKGRSRSSKNRGPQNEDGNADSANGYTSGDNAPKSSSGRKEQLPPADITIENIVEGGRRKRAKFESSELPLFAPPQMPAVTSNPSVSPVRRFEARHSLPYIQTGQNPFSTPRPPLTSPQSYNPSYSGSAPYNPANTDSRRSRGSFGYPSGQGMGPGMQFVPTPEPTVGSCMSEEDKDVAIQLMRLGEMSNHGRASASTVDDGFSGRADASSTGATSDAESLAPEDMHAGQRQKLDAMGNHKKIFNNTDGTFHAEASGDEADDSDVDDSLPPSVVKKPKATGLNGTGRARSMPANKAKTTKTAKPKLKKAPAAVGPMSPASLPASRKQSINSNAAFPLPLGEEETPDLSTKPRCQRCRKSKKGCDRQRPCGRCRDAGIPADQCISEDEGNGRKGRYGRHMGVPIKREDMPPPATAPTAAVMTGATTAAMLLPAAPIAPASAIAGLASPSAAGKDKKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDX6</accession>
    <name>G0SDX6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0053350</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695672.1">
        <property type="nucleotide sequence ID" value="XM_006695609.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0SDX6"/>
    <dbReference type="GeneID" id="18259373"/>
    <dbReference type="KEGG" id="cthr:CTHT_0053350"/>
    <dbReference type="eggNOG" id="KOG1815">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_239971_0_0_1"/>
    <dbReference type="OrthoDB" id="1431934at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20336">
        <property type="entry name" value="Rcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="1236"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="493"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="722"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1487"/>
            <end position="1647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1659"/>
            <end position="1679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="533"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="579"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="593"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="722"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="804"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="828"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="873"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="913"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1496"/>
            <end position="1505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1506"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1568"/>
            <end position="1577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1590"/>
            <end position="1601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1617"/>
            <end position="1628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1629"/>
            <end position="1647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS18727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1731" mass="194205" checksum="88017C5CB1A59B08" modified="2011-10-19" version="1">MSTPPKPTQTLPPEIITSILEKYYSEPPRCALSLLCPEWKLCPRKTPALDVLLRSVRIDVYTAPLQNHKWLFVDRADGRDDELEEESVVLDEGTVETRFGGRCFCSEEGGGWVLVGGVGDPGCRVARGAPRPSLGGTSKGPSSGRRSVLEKGVIDGRVGKRSEQKKPTAAATTGLGYRTPDRWMCALDKFYQREMVRRWASNAVFVVGQEIPRGPLFRPEVVHWPGVTERRLVLERMVRLRSEEVMGLLPFRLDYVTVDEVREDEEDEDWAEGVVWRGRRVWADDGLEKERLPMTVVEEGEQEPIYTYVFQLIRHLVVNTTPSVTALDTAEVYSRRLGQLKTYLQQSAAVSQSSPTNEFDATQPNFLNPPSSDHNHEAWVYPSLSDSDIQILQQAHLDEKRLPFIIDYSKLPNLETLCLDLRGLSYPPTAAASQNPRLRRPKAFLTERAVCSKLRDLWYRGLKLLVIAGLRSWNRYPGPEPEATTELFDPFLRSAGHQGNQSPRYASWPKEQSEKRRPRPAMHGIRTPGAPANTATKLGNDQSALRTRMSARFTRSRRNSSIGGAGVGEQQDPTSLGTGRERQEEERDSREQSDEEEEEDEEEEAEEEPVVVTTWTAVNGIVMRNGIEIDTIGIVIDDVDTSTTVTVTVTVIVIARTMTAIIIMIITSTGSIESGIRIETENERERENTGSIGNIGNIGNIGNIIAGVQSLILPLTQQTQQQQQQQQQQQQPQTQSQSRRQPEPEPQPQPTISRPRASSRPSRAEAHSQLVQTAHRRVRQADPEPAPQPVLQVAAQTMPQPALAHQPVAQPMPAQAQTATARDNLSSPGATTRPATEPAPAIATTPRSLTTATPTTSTAEGLASEPPREQRQHQQTQQQTQQPPAPSRQANGGPSRPQQQQRQGRQEEVRSAPATTSRPSQGQGEPSRPPNPPTLREPTRPTTPPVTIHLQPLDPRYRQLTFPIPPGVPLHTSLTLTLQTHYFLSPEAVFTFYNIKGKPIPADERAPQNRQGVNNALGGGHMTVWYRTVKGTRQDTRHWAFKFTWWEGDRKGERLDSAMERTLRQEIESGATVGRLRQVLGDLLGVLDSNRVMLVAVDGMRQGALQGNGWEVKKIREGWKGRWIGVDVLPPGRYILLKRGNQARKYVFHPARGKIDAGMSVGRLGRYVKMKILEGAAKGGYLNSRLPREEWEVMLEMDGQRLRDDVQVQWAKMYEVVLPGNIERAFEREEEWLIGSTATCGTCLEEKTNDEFLLGKITSTCRHEEIDILDNTIEDRHRICRDCLQGWLRARSDRWGSSPPRCPITGCNQVLSYTDARKHMTEDVFQRYDYLVLRTTLGQLDEFVWCLNPDCQSGQLHYPEAEWCPEFQCGGCQRRYCLTHRMPWHEGQTCEEFDRRTHGRRRDDSEAEGRSCPRCKKRIYKEIGCDHMTCVCGQEFCYQCGALYPPTLPGQIARTTHFPNCPHFEPVPLDRAPSPFLPFILNRFRPPGLLGGGGGDNDDHDDEDPFFPPPPPRQARPPFFSPPGGPGPAPLPGHVLENGAIRFGDGQFQPPRLRPTTRARSRVRPDGNPGPPVPGPAAPARRNTVGGGAPAPAQTQGQPPARIIGIAPRFPFDVHMPPAPVPPEPEPVQVPQQNLWQQQQQQEQEQRWLEMQWQQEVNAFDPPGQGRGRELGGGHEIGQPQVHLHPQLLERPHFQFDREDGENLVVFLPAAGLVNGRARLEGSRRRSRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0SE36</accession>
    <name>G0SE36_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0062280</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696544.1">
        <property type="nucleotide sequence ID" value="XM_006696481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SE36"/>
    <dbReference type="STRING" id="759272.G0SE36"/>
    <dbReference type="GeneID" id="18260266"/>
    <dbReference type="KEGG" id="cthr:CTHT_0062280"/>
    <dbReference type="eggNOG" id="ENOG502SK9A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023186_0_0_1"/>
    <dbReference type="OMA" id="NGPRDSW"/>
    <dbReference type="OrthoDB" id="5382953at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="614" mass="68301" checksum="62776E567CFFA705" modified="2011-10-19" version="1">MRPYTAKTARHWRCTEPVPIEITGSDQYSFGDHPVRLWVSGASGWFEIKPSRRFEPIFREIHEAVTLYYGIFDAYNNHFAEKSKKKGRKTQPSLDTVLFKYALKAGNGIFHEEAKALCHKWADFLIAHFPKEGACDGWSWENTDFAKWLRDSHPEVERKLANIVQEIAPPLPPPPPSPPSVIVPKASETSQPPRKRKGRPSKTANRPSDTREAKIQDSISSRSHSPHPKPATKVTPVPLPERYRSFINQPTALQTSQPTPARPVATSQSASNQVSGPSTSETADELNDVPMTDSDAESPVDRLLSVFRELAVELDISKASPSTVYSKLFFKCKMKEYGVAKDIVLYYSKELFARLGPEWKGTRFLKWLQEESNKPWVPMTGIREEDIPSQTYRRATKAATKVLAIHQPLAPLPRPINLHTKPDFPSQQSDEDISDSGVAFLRPRRGRKSGKVATLRPLPSTSRKRPVSELLEDVSSSSDDDVGDEVAAILNLPEDIAASGSRLPLPDGVVRVVVHAEPLMDTTPRGPNGTWTCEHEGCGYVVRAAEEQEGQDLIREHFRDHEAAAERAQLVVQESRSHGNIPIKYVYACFPPVLLLVASPVSSPGSGSQVEARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0SE45</accession>
    <name>G0SE45_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ribosomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0062380</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696553.1">
        <property type="nucleotide sequence ID" value="XM_006696490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SE45"/>
    <dbReference type="STRING" id="759272.G0SE45"/>
    <dbReference type="GeneID" id="18260276"/>
    <dbReference type="KEGG" id="cthr:CTHT_0062380"/>
    <dbReference type="eggNOG" id="ENOG502S0A4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089054_0_0_1"/>
    <dbReference type="OMA" id="CSQFFVG"/>
    <dbReference type="OrthoDB" id="6021263at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024388">
        <property type="entry name" value="Ribosomal_mL58"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28266">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L20, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28266:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12824">
        <property type="entry name" value="MRP-L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="251" mass="28487" checksum="EE6471858FCC38EB" modified="2011-10-19" version="1">MEAIFSRPALACASRAVNPLHPAATAATTSSARLLFFTNTNAIGVPATVRHASTSRRHRRMLRIPPHPSFLTKPDTDQIIFNPPSSAPSVYHTPFKFLPKSDPRRRAALASELFSQPSASTQTQSSSNPADILTQYDQMNPPKGDFNVEDIPPLRQDLQPPSNPRHHLTKEDIEEMRRLRAEDPIKNSVLSLARRFNCSKLFVLMCCKTTPEHAKRIREREEKIRARWGPVKRAAREERQIRKEMILRGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0SE72</accession>
    <name>G0SE72_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homoserine kinase</fullName>
            <ecNumber evidence="3">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CTHT_0062710</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Commits homoserine to the threonine biosynthesis pathway by catalyzing its O-phosphorylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-homoserine + ATP = O-phospho-L-homoserine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:13986"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="3"/>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696580.1">
        <property type="nucleotide sequence ID" value="XM_006696517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SE72"/>
    <dbReference type="STRING" id="759272.G0SE72"/>
    <dbReference type="GeneID" id="18260309"/>
    <dbReference type="KEGG" id="cthr:CTHT_0062710"/>
    <dbReference type="eggNOG" id="KOG1537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041243_2_1_1"/>
    <dbReference type="OMA" id="CANRIPH"/>
    <dbReference type="OrthoDB" id="195231at2759"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000068">
        <property type="entry name" value="Homoserine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00191">
        <property type="entry name" value="thrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861:SF1">
        <property type="entry name" value="HOMOSERINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861">
        <property type="entry name" value="HOMOSERINE/4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000676">
        <property type="entry name" value="Homoser_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00958">
        <property type="entry name" value="HOMSERKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="11" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="12" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="7" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="16">
        <location>
            <begin position="72"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="17">
        <location>
            <begin position="270"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00054121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGS18249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="357" mass="38707" checksum="4337B05222D0CF05" modified="2011-10-19" version="1">MAIESFIIKTPCSSANIGPGFDVIGLALSMYLELHVTIDRSKKTSTYPLNCRITYEGEGEGTDEISLDPEVNLLTRVALYVLRCHDQRSFPCETHVHIKNPIPLGRGLGSSGAAVVAGVMLGKECGGLKHLTRERLFDFCLMIERHPDNVGAALFGGFVGTYLMPLKPEDAARKEIPLSEVLPAPAGGIDTGIKPPEPPIGIGHHIKFPWAPEIKAVVIIPDFEVPTAKAREVLPAQYPRLDVTFNLQRIALLPVALGQSPPDPELIYLAMQDKLHQPYRQTLIPGLTEIVESMTPSTQPGLLGVCLSGAGPTILALATANFNEIAESIIAKFRANNIQCSWRLLELAEGGTQVLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0SF07</accession>
    <name>G0SF07_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA polymerase II subunit A C-terminal domain phosphatase SSU72</fullName>
            <shortName evidence="10">CTD phosphatase SSU72</shortName>
            <ecNumber evidence="10">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0060370</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. SSU72 is required for 3'-end formation of snoRNAs.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the cleavage and polyadenylation factor (CPF) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SSU72 phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="10"/>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696354.1">
        <property type="nucleotide sequence ID" value="XM_006696291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SF07"/>
    <dbReference type="STRING" id="759272.G0SF07"/>
    <dbReference type="GeneID" id="18260075"/>
    <dbReference type="KEGG" id="cthr:CTHT_0060370"/>
    <dbReference type="eggNOG" id="KOG2424">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062463_0_0_1"/>
    <dbReference type="OMA" id="TQPNVYQ"/>
    <dbReference type="OrthoDB" id="57957at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000039">
        <property type="entry name" value="RNA polymerase II subunit A C-terminal domain phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000189">
        <property type="entry name" value="SSU72p Phosphatase and transcription/RNA-processing factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006811">
        <property type="entry name" value="RNA_pol_II_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20383">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04722">
        <property type="entry name" value="Ssu72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS18023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="264" mass="29482" checksum="A9E0BF032827F1F3" modified="2011-10-19" version="1">MTTEHSSPVSMDTNGAAGPSPAQNGQQNEPPFRLKFCTVCASNQNRSMEGHLRLSQAKYPVISFGTGSLVRLPGPTITQPNVYKFNETSYDSIYKELEAKDPRLYRMNGLLNMLGRNRSIKWGPERWQDWQIGMPRVKHEKDLGSQGMEAGVPDIVITCEERCWDAVIDDLLMRGSPLNRPVHVINIDIRDNHQDASIGGSAIVDLADSLNKVACEERERVGPVAFDSGSAAGRATFDERVPEVLAAWQERWPDLPATWTLSWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0SF34</accession>
    <name>G0SF34_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0060650</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696381.1">
        <property type="nucleotide sequence ID" value="XM_006696318.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0SF34"/>
    <dbReference type="GeneID" id="18260103"/>
    <dbReference type="KEGG" id="cthr:CTHT_0060650"/>
    <dbReference type="eggNOG" id="ENOG502SS2G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_262811_0_0_1"/>
    <dbReference type="OrthoDB" id="5376804at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021514">
        <property type="entry name" value="DUF3176"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394:SF5">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11374">
        <property type="entry name" value="DUF3176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1183"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="941"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1074"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="578"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="659"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="942"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1074"/>
            <end position="1089"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS18050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1284" mass="136845" checksum="8C8BD17C40549BBB" modified="2011-10-19" version="1">MAANRHQHDHNHYPSCLDSSSMSAPPPQSSYPAHSQPELQQQHYYPTTTTAGDDNFLPPTTLDHNPSLSLVPSSNPDPTQTFTPDADQPHLQREHPTSQGSQIHRMNTVLSAVTSATSRFTVSPPSSLPSPTYPVNTTLNPDPNTNAVISDFSFDGNPIPGARAEAEHNPVAGASPQPEAGVPGLQLPPPGIGSGNEGGGEAEGVGTYASGYSFNTTGSGEGSGSGYSPISGIQYAYGYPYGFGSEFGSGGQGGTIASSSGNGNETGIGTNEILAIVGAARQDLGATQGQGGEGSESRDQGHQQGGKRDTWPAPLNIPISKESAPVPVTTTATSSLPSISISPPLPSLTSMTTAAGIPTITTSPPPTQPYPWPWTSHPWVRPLAPNLWQTAPHPRDIPFPVSAQWRGSREMQELERARARALEREREESQEREGEGRGQQVSDESEEGEDGEGMKIMGLGNESGEVTIETAVKKVIGRGKGPSRAEGEPGSGAWPGPVTAATTTTTRASEPVTSISADPAPTTRRSEERNQPQQPFMHYEDLSYPGFVPNSPTSDDSMLPARTEDAAHQERPLPPLPSATARAETAASASVPHSISIIQMPGPENETPSRETVFRSSRERQTPPLPPVPPGNISNQNNDSLPEPRREKQPRAKRVLLQSPSSSSNSRPPGNLWTYTHPFLPELLSLISSIVCLASICALLKRYDNHSLRDWPLQVSLNTVVAFLTAICQVGLWRALSEGLAQLKWNMLARGGAVNTMNKTLGDWEVIEDARRGVAGCVRVLVGRKGRTLGITSATLLLTSFLLTPLTQGAITYPYRHLSAGSGTATVARSESYIHPTPYTSLDAREKQAIHVGIHHPVDESIPHLQPTCSSGDCQWPDFSSLAVCAAVADVSDRLTITQTNNTSGGGVSLPVSNETQLLYKATLPNGAFLLGDASTWNLNISSPGAPQSSSSTRGGENGQDDDDAYDGNFLPVQTSLAFSSQDGRVLSGITNLFFVYTNTTSATNQASSRNSSSTSTGQRHIFRAAEVLLHFCVNTYQVSTRRGISISTVVHSSALTVLQQQGVVTTARTILRSNLSSPTNPDTGSSSVGRRAVPDTPRAAVAMLSLSTSTTVGGEENLHPLPPQQQQVDVYTVKRDDVELLSRYIRGVFAGSYSRRIRAMSSTGGVVTGTVLATESYVRVRWAWLSFLAIQVGLTASFLLGIIVQTAVWDVKVFKGSPTAALLAISAGDKEYLEEQGILLDTSLSSDDDLKRKLQTITCRFQPGEKGWTLQLGKRQQDGDFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0SF43</accession>
    <name>G0SF43_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative glycerol transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0060740</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696390.1">
        <property type="nucleotide sequence ID" value="XM_006696327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SF43"/>
    <dbReference type="STRING" id="759272.G0SF43"/>
    <dbReference type="GeneID" id="18260112"/>
    <dbReference type="KEGG" id="cthr:CTHT_0060740"/>
    <dbReference type="eggNOG" id="KOG2997">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3860">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_271471_0_0_1"/>
    <dbReference type="OrthoDB" id="420606at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000052">
        <property type="entry name" value="F-box protein (Pof7), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045464">
        <property type="entry name" value="Hrt3/FBXO9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051085">
        <property type="entry name" value="MB_O-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285:SF18">
        <property type="entry name" value="PROTEIN-CYSTEINE N-PALMITOYLTRANSFERASE RASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19270">
        <property type="entry name" value="FBO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="583"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="724"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="760"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="900"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="940"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1059"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1083"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1116"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1158"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="8">
        <location>
            <begin position="221"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="157"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="314"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS18059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1194" mass="134754" checksum="42F12856AF97A37F" modified="2011-10-19" version="1">MSSYEEPNNPELESFRQQWRAEVQARAARHASSSQRQQHHQHHESHAGPSSTSPAQPIRVTTPRGKPPASAKKTVVKDSEDDYVRSQPFDEPVHAAGAAQGEKGKGAAGTQQEPVTALEHYERAVEKEAAGNLGESLRLYRKAFQMDDQVDQKYRNKHFPKKPAPVSSSTSATGAGFKTTPTSTQKQEPSQPIPLKDLIESFSSLTITPAPPVIEGTPPPPCPIASLPEEILVQILEDVAINDVGDFVRLSLVCKRFAYLVATEDRIWRRICLGSEFGFGGMHYYWQCQITWEPLTEADLIREAEESSNAQDDPNTSGTTTPTTTTSFPAPALTLAARARLHAEEKRAVTLAFYNSPLYSSSWQRMWRLRPRIRFNGVYISTVNYMRPGLGVNQVTWGASPIHIVTYYRYLRFFRDGTVISLLTTAEPGEVVHHLTKEYVAQFAGQNNIPAGANLPGAVMRSALKGRWRMAREGENPGASLSEIEGDVIVETEGVTTLPSTNFNTNANANTTPLSYTMTPRQKGGGGSGGPISFFKSVYDLETLDTRFVVPASVPYRAAVADPSFGKPDKRATAPRWHTFEFWVYYLVFATAVPYMFWVAYDVSRPEDPRYKKYQKYLSDGWIPGRKIVSLYNPSPPPPRSPPFSLQSVIQDRRDEANHHQDVSDAQYHTFRTNLPYMALLLILHPLARKLWNTLVHPIPADAATSPSEAAADLRQRQRTSFDYAFALLYLVALHGFSAAKILLILAANYRLATSLPKRWIPVATWTFNICILFANELCQGYRFRDMAMLWTGPVKKGDPVPPVVQLGRWLDRHGGLINRWEILFNITVLRLISFNLDYYWSLDRRASSPIEVRLVPSHFCLYRNKSNVPKKKQLDPSSLSERDRVALPAPSHAFTFRTYLAYAIYAPLYLTGPILTFNDYISQSRHRPATISGARTLRYGIRFFLALLAMEIILHYDYVCAISKARPNWSSYTPAQLSLLSYFNLHLIWLKLLLPWRFFRLWSLTDGIDPPENMLRCVSNNYSTLSFWRGWHRSYYRWLLRYIYIPLGGTDFSSAAKAVKSVVTYLTVFTFVALWHDIKLNLLVWGWLIVLFFLPEIAANYLFPKRKWEAARPTAYRMLCGVGAVGNVLMMMMANLVGFAVGLDGLESIIKGIFREYQGLVFLGTACGALFVGIQVMFEIRAGELRRGVNLKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G0SF55</accession>
    <name>G0SF55_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative transcription elongation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0060860</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696402.1">
        <property type="nucleotide sequence ID" value="XM_006696339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SF55"/>
    <dbReference type="STRING" id="759272.G0SF55"/>
    <dbReference type="GeneID" id="18260124"/>
    <dbReference type="KEGG" id="cthr:CTHT_0060860"/>
    <dbReference type="eggNOG" id="KOG1105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037637_1_1_1"/>
    <dbReference type="OMA" id="RFVVMTH"/>
    <dbReference type="OrthoDB" id="44867at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001139">
        <property type="term" value="F:RNA polymerase II complex recruiting activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031440">
        <property type="term" value="P:regulation of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13749">
        <property type="entry name" value="Zn-ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000001">
        <property type="entry name" value="Probable Transcription elongation factor S-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.30:FF:000003">
        <property type="entry name" value="Transcription elongation factor S-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035100">
        <property type="entry name" value="TF_IIS-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003617">
        <property type="entry name" value="TFIIS/CRSP70_N_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477:SF0">
        <property type="entry name" value="IP08861P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006704">
        <property type="entry name" value="TF_IIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00510">
        <property type="entry name" value="TFS2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00509">
        <property type="entry name" value="TFS2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="11">
        <location>
            <begin position="4"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS central" evidence="12">
        <location>
            <begin position="144"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS-type" evidence="10">
        <location>
            <begin position="261"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="85"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS18071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="303" mass="34171" checksum="8433F39EE806582C" modified="2011-10-19" version="1">MDDQELTRRIRLLTKAVASEPASVVIEILEELKKEKAPTEEQLRVGAPSTKAGVAVGKLRSHQDKNIARIAGEIVSKWRKNVDAAKDAKKRKLEQQQQQQTNTPTPKDSPAPPSSAYNTPYQGDPEKRHFKVDNVDISRTGNKVRDGCIGVLYNGLAYRRTESIEEILQKAMEVEAAAFEVYKGDTPEYRSKIRGLMTSLKRKDNAELGDRVMKGEITPHQFVKMTEKELASEAQRLRDAQLERENMLKAQVPMAQKSISDSLQCSKCKQKKVSYSQAQTRSADEPMTTFCECTVCGHRWKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0SF61</accession>
    <name>G0SF61_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0060920</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696408.1">
        <property type="nucleotide sequence ID" value="XM_006696345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SF61"/>
    <dbReference type="STRING" id="759272.G0SF61"/>
    <dbReference type="GeneID" id="18260130"/>
    <dbReference type="KEGG" id="cthr:CTHT_0060920"/>
    <dbReference type="eggNOG" id="KOG1379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029404_7_2_1"/>
    <dbReference type="OMA" id="AYSEPQT"/>
    <dbReference type="OrthoDB" id="60843at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE PTC7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13672">
        <property type="entry name" value="PP2C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="105"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS18077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="433" mass="46496" checksum="39CC79888D0E448B" modified="2011-10-19" version="1">MATRFLFYSRPASTTPLARLASQTARASSILRSVPTFLTRSTQNRPSTASPILQASFYSTPSDAPSNTRTKFVYNVAASYIAKGRAYDPSIHLFQFDPYNRVSPPNGAARGKKARPESGQDAFFVSRLGTNPGEVALGVADGVGGWMESGVDPADFSHAFCNYMAAAANAAAEISAYTGKPLTARQLMQLGYDAVCHDPSIRAGGSTAIVGLLTANGRAEIANLGDSGFLMLRRNGVHAYSEPQTHAFNTPYQLSVVPRSMLLRAAAFGGGQLMDQPADADLIRHQLRHGDVLIFASDGLWDNLFNQQILRIVSQVMARAGAWVQNSQTGVQVAPDLRPFTQLQQENTASSNVKLPSPPNTLQSLLATEIVAAAKAASVSPHLDGPFAKEVKKYYPNESWHGGKEDDICIVVVLVSEEECPSQEQTPAPKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFB3</accession>
    <name>G0SFB3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase RBP11-like dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0061440</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696460.1">
        <property type="nucleotide sequence ID" value="XM_006696397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFB3"/>
    <dbReference type="STRING" id="759272.G0SFB3"/>
    <dbReference type="GeneID" id="18260182"/>
    <dbReference type="KEGG" id="cthr:CTHT_0061440"/>
    <dbReference type="eggNOG" id="KOG4392">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090381_2_1_1"/>
    <dbReference type="OMA" id="MNAPSRY"/>
    <dbReference type="OrthoDB" id="10248581at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06926">
        <property type="entry name" value="RNAP_II_RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037685">
        <property type="entry name" value="RBP11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008193">
        <property type="entry name" value="RNA_pol_Rpb11_13-16kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF16">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01154">
        <property type="entry name" value="RNA_POL_L_13KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="6">
        <location>
            <begin position="40"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS18129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="146" mass="15741" checksum="185CA9DADB2D8D48" modified="2011-10-19" version="1">MAFTNFRHSDNLQTGFELFLLAEGEKKITEKVVTGMANTSDFIILKEDHTIGNLLSEHLKQAPHVMMAGYKIGHPNVPEVLVRVQTDGTITPREALVNVCKQLVAAYGQLGREFQKELALRQYADQGAGAADAAAGAIGGTGQNGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFN0</accession>
    <name>G0SFN0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein l34-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0071430</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="476" last="476">
            <title>High-resolution structures of a thermophilic eukaryotic 80S ribosome reveal atomistic details of translocation.</title>
            <authorList>
                <person name="Kisonaite M."/>
                <person name="Wild K."/>
                <person name="Lapouge K."/>
                <person name="Ruppert T."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="35079002"/>
            <dbReference type="DOI" id="10.1038/s41467-022-27967-9"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.90 ANGSTROMS) IN COMPLEX WITH ZN(2+)</scope>
    </reference>
    <reference evidence="10 11 12" key="3">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e56910" last="e56910">
            <title>Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation during pre-60S biogenesis.</title>
            <authorList>
                <person name="Lau B."/>
                <person name="Huang Z."/>
                <person name="Kellner N."/>
                <person name="Niu S."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
                <person name="Cheng J."/>
            </authorList>
            <dbReference type="PubMed" id="37129998"/>
            <dbReference type="DOI" id="10.15252/embr.202356910"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <reference evidence="14 15 16" key="4">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e57984" last="e57984">
            <title>Structural insights into coordinating 5S RNP rotation with ITS2 pre-RNA processing during ribosome formation.</title>
            <authorList>
                <person name="Thoms M."/>
                <person name="Lau B."/>
                <person name="Cheng J."/>
                <person name="Fromm L."/>
                <person name="Denk T."/>
                <person name="Kellner N."/>
                <person name="Flemming D."/>
                <person name="Fischer P."/>
                <person name="Falquet L."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="37921038"/>
            <dbReference type="DOI" id="10.15252/embr.202357984"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.12 ANGSTROMS) IN COMPLEX WITH ZN(2+)</scope>
    </reference>
    <reference evidence="8 9" key="5">
        <citation type="journal article" date="2023" name="Nat. Struct. Mol. Biol." volume="30" first="670" last="677">
            <title>Structural inventory of cotranslational protein folding by the eukaryotic RAC complex.</title>
            <authorList>
                <person name="Kisonaite M."/>
                <person name="Wild K."/>
                <person name="Lapouge K."/>
                <person name="Gese G.V."/>
                <person name="Kellner N."/>
                <person name="Hurt E."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="37081320"/>
            <dbReference type="DOI" id="10.1038/s41594-023-00973-1"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.20 ANGSTROMS) IN COMPLEX WITH ZN(2+)</scope>
    </reference>
    <reference evidence="13" key="6">
        <citation type="journal article" date="2024" name="Nat. Commun." volume="15" first="716" last="716">
            <title>Methionine aminopeptidase 2 and its autoproteolysis product have different binding sites on the ribosome.</title>
            <authorList>
                <person name="Klein M.A."/>
                <person name="Wild K."/>
                <person name="Kisonaite M."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="38267453"/>
            <dbReference type="DOI" id="10.1038/s41467-024-44862-7"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.10 ANGSTROMS) IN COMPLEX WITH ZN(2+)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697413.1">
        <property type="nucleotide sequence ID" value="XM_006697350.1"/>
    </dbReference>
    <dbReference type="PDB" id="7OLC">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="Lg=1-119"/>
    </dbReference>
    <dbReference type="PDB" id="7OLD">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="Lg=1-119"/>
    </dbReference>
    <dbReference type="PDB" id="7Z3N">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="Lg=1-119"/>
    </dbReference>
    <dbReference type="PDB" id="7Z3O">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.30 A"/>
        <property type="chains" value="Lg=1-119"/>
    </dbReference>
    <dbReference type="PDB" id="8I9X">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="Lg=1-119"/>
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        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="Lg=1-119"/>
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        <property type="method" value="EM"/>
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        <property type="chains" value="Lg=1-119"/>
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    <dbReference type="PDB" id="8PV1">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.56 A"/>
        <property type="chains" value="Lg=1-119"/>
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    <dbReference type="PDB" id="8PV2">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.63 A"/>
        <property type="chains" value="Lg=1-119"/>
    </dbReference>
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        <property type="resolution" value="2.80 A"/>
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    <dbReference type="PDB" id="8PV4">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="Lg=1-119"/>
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    <dbReference type="PDB" id="8PV5">
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        <property type="chains" value="Lg=1-119"/>
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    <dbReference type="PDB" id="8PV6">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.94 A"/>
        <property type="chains" value="Lg=1-119"/>
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    <dbReference type="PDB" id="8PV7">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.12 A"/>
        <property type="chains" value="Lg=1-119"/>
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    <dbReference type="PDB" id="8PV8">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.91 A"/>
        <property type="chains" value="Lg=1-119"/>
    </dbReference>
    <dbReference type="PDB" id="8PVK">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.55 A"/>
        <property type="chains" value="Lg=1-119"/>
    </dbReference>
    <dbReference type="PDB" id="8PVL">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.19 A"/>
        <property type="chains" value="Lg=1-119"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFN0"/>
    <dbReference type="EMDB" id="EMD-12976"/>
    <dbReference type="EMDB" id="EMD-12977"/>
    <dbReference type="EMDB" id="EMD-14479"/>
    <dbReference type="EMDB" id="EMD-14480"/>
    <dbReference type="EMDB" id="EMD-17004"/>
    <dbReference type="EMDB" id="EMD-17950"/>
    <dbReference type="EMDB" id="EMD-17951"/>
    <dbReference type="EMDB" id="EMD-17952"/>
    <dbReference type="EMDB" id="EMD-17953"/>
    <dbReference type="EMDB" id="EMD-17954"/>
    <dbReference type="EMDB" id="EMD-17955"/>
    <dbReference type="EMDB" id="EMD-17956"/>
    <dbReference type="EMDB" id="EMD-17957"/>
    <dbReference type="EMDB" id="EMD-17969"/>
    <dbReference type="EMDB" id="EMD-17970"/>
    <dbReference type="EMDB" id="EMD-35287"/>
    <dbReference type="EMDB" id="EMD-35288"/>
    <dbReference type="EMDB" id="EMD-35289"/>
    <dbReference type="EMDB" id="EMD-35290"/>
    <dbReference type="SMR" id="G0SFN0"/>
    <dbReference type="STRING" id="759272.G0SFN0"/>
    <dbReference type="GeneID" id="18261181"/>
    <dbReference type="KEGG" id="cthr:CTHT_0071430"/>
    <dbReference type="eggNOG" id="KOG1790">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118652_1_1_1"/>
    <dbReference type="OMA" id="RCHKCVR"/>
    <dbReference type="OrthoDB" id="277449at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.370.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008195">
        <property type="entry name" value="Ribosomal_eL34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038562">
        <property type="entry name" value="Ribosomal_eL34_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018065">
        <property type="entry name" value="Ribosomal_eL34_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10759">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01199">
        <property type="entry name" value="Ribosomal_L34e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01250">
        <property type="entry name" value="RIBOSOMALL34"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01145">
        <property type="entry name" value="RIBOSOMAL_L34E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6 7 8" id="KW-0002">3D-structure</keyword>
    <keyword evidence="6 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 7 8" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="6 7 8">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7 8">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7 8">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7 8">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS17795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="7OLC"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="7OLD"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="7Z3N"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="7Z3O"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="8I9X"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="8I9Y"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="8I9Z"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="8OO0"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="8PV1"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="8PV2"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="8PV3"/>
        </source>
    </evidence>
    <sequence length="119" mass="13461" checksum="BB138E8352BF9AE5" modified="2011-10-19" version="1">MAPTRVTYRRRNPYNTTSNRTRVIKTPGGQLRVLHIKKRGTAPKCGDCGIKLPGIPALRPREYATISKPKKTVQRAYGGSRCGNCVRDRIIRAFLIEEQKIVKKVLKEQSQAEKKASKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFV2</accession>
    <name>G0SFV2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0072240</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EGS17867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697485.1">
        <property type="nucleotide sequence ID" value="XM_006697422.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="18261262"/>
    <dbReference type="KEGG" id="cthr:CTHT_0072240"/>
    <dbReference type="HOGENOM" id="CLU_2812128_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS17867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="67" mass="7948" checksum="42172F2D8D0A56E4" modified="2011-10-19" version="1">MCWWNNIYYEQCKHSVIVKVPYSCEEYTRHTYGPCQPTKSNQHRVTPGISYGLCPDCEELLKKYTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFY3</accession>
    <name>G0SFY3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0072570</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697516.1">
        <property type="nucleotide sequence ID" value="XM_006697453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFY3"/>
    <dbReference type="STRING" id="759272.G0SFY3"/>
    <dbReference type="GeneID" id="18261295"/>
    <dbReference type="KEGG" id="cthr:CTHT_0072570"/>
    <dbReference type="eggNOG" id="ENOG502T4C8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_309935_0_0_1"/>
    <dbReference type="OrthoDB" id="4590776at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="696"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="859"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="903"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="728"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="784"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="859"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="923"/>
            <end position="934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="950" mass="104774" checksum="8E35349A681F886C" modified="2011-10-19" version="1">MPPKKQPAAVPPDQKTFTVIPMPISIQQLMSRPHDGKDSHPPMTSKQAQKLYRQKNRQPRMSKEEQRRLERLEQERIRKELEQEKRLNRAQFLREKKKQQEQAKLLERKRQGLPLVDPRPSQNVITKFIRGPVVGQKRDASGSIVNHNNESHTEMELDGAENQEDEMEEYRARKRLRLEALDNNHQGNDAFNATEDNNFRALRMLPPSSRGQHSGPAPGGLQSSITSQELKTVAAGVSTLQNVVEGTTQSNTIVPATSHKATTTTAQNIYTSLNPQLAAQSVTNQSVRKTANPEQRVQQLSGLECDSVSNIKSTMRSSPSRDNSHPAQQFLNARSSMQHPLQPRYTRSGIQKPNHSPSYVPSPLRKSLEPQTPTSTQLFLMTHADEFLLSASQEARELAGGDYVPEQPKPAQIPALVKQSGFRTKPSLVQQLQIHTVSKTAPQQFVPHQQLQKPVTLKNAAPKPSSAQTPGPVQNAASVRQPPNPAPVKPMAQQPVISRKQINRFAATRIQSNRVVSFLAPLPKPAPAAPAPLNSKPKLIEETAADVIANISFQDIMSTQEERELEGASRKDAKVTKLLNELSFFSTQDLFISTQEASDLERPAPIKAKSVKELVAAEELKLMSSDFRDIEGSGKLGKHANGVTEPKTASFCTQDVTLTSSDLQDIEAPAAAQTSISKSAIEVVPANRPSVQAVAADSDSEIKDIPSPVRPKPCRSLEIKPPPFIIRNINQPSAGTPHGSSNLRLLHSFLPPSHRTTSPKGDQAAAIKKPVRCPLEDIEDPESDKENGVLDKNDNKEGAKDKEKKADSTTPPPRREKRRFFTPSGNGIRLLMTISRNKKAKEQEIERRRVQEMRERWAQATASNSNNTNATNTTGSSCDHNTIANSKNNTSGKLEAQIIPCSPPKQITAVPPVSSRRRASPTVHPQLSSSQSTDYGDPNLDDEDFVLLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G0SG28</accession>
    <name>G0SG28_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription factor SWI6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0064820</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Transcription factor that plays a role downstream of the MCK1-MKK2-MPS1 cascade. Required for hyphal morphogenesis and pathogenicity. Is an important oxidative stress response regulator and plays a positive role in the regulation of extracellular peroxidases.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696785.1">
        <property type="nucleotide sequence ID" value="XM_006696722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SG28"/>
    <dbReference type="STRING" id="759272.G0SG28"/>
    <dbReference type="GeneID" id="18260520"/>
    <dbReference type="KEGG" id="cthr:CTHT_0064820"/>
    <dbReference type="eggNOG" id="ENOG502QPWC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009666_1_1_1"/>
    <dbReference type="OMA" id="HHIAMMA"/>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.10:FF:000001">
        <property type="entry name" value="APSES transcription factor (MbpA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000365">
        <property type="entry name" value="Start control protein cdc10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF3">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0183">Conidiation</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="12">
        <location>
            <begin position="55"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="388"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="528"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="213"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="574"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="633"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="738"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="225"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="578"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00059984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS17167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="824" mass="90220" checksum="EF5622A7605E2A20" modified="2011-10-19" version="1">MQPPQASAGSQQVQSQPSSQQSYSMSQPSSQTNTQSGYRQYTEPPKLNPEPDMEIYSAVYSGVNVYEMEVNNVAVMRRQADGWLNATQILKVAGVDKGRRTKILEKEIQTGEHEKVQGGYGKYQGTWIPYERGVEVCRQYGVEETLKKLLTHKRGQEGQGADVDTPTKEQAMAAQRKRMYNAASQENRANGSSGTFFKNISSTASHAINAISKARFDSPGPRNRNGLSTRAPSFNRQPSMQEGDNPANSQQSYVSDFAHGDQASQGQAAEGGEQPPRKRQRVLTPANSFGGTTPNYPHPDGGYGANFPGSPTEPNESFIYSQHGVVDPEANWAPGPLRPLPWDNGPEAEHKRNILMSLFMDQNPPDESKKRLLRGMIPQDLDAPIDTQSHTAVHWAATLARIPLLRALIEAGASPFRVNAAGETALMRACSVTNAMDHNAFPELLDVLGCTLDVRDDRGRTVLHHIAFTSGVKGRNASCRYYLESLLEWVVRQGSAPSTQNQNSNGPVVPKMSIGRFMSEIVNAQDNAGDTALSIAARIGNRSIVSQLLEVGADPNIRNRAGLCPVDFGIGTEDHVNGGSTDRNASQGSSQKTSQNSEAVVNSISNLIEESSSIFQDELKKKQESIDALHSSLRTTSAQVGEARRALEALQEKLKAQQLARQKVINLKRACDEEEYHLLQLEQRHGRLDVASENAWEMELEAVMNALGLVKDGEATSSPANVTLTDAAKEQIAKLPSSAVLRARIKALRERSAQTEQAVEDLRARSKEREMKYRRLVALCTRRPDSEVDALIDTLTKAVESEKGELEIGRVRRFLGGVEGASLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGK3</accession>
    <name>G0SGK3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0066640</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696960.1">
        <property type="nucleotide sequence ID" value="XM_006696897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGK3"/>
    <dbReference type="GeneID" id="18260702"/>
    <dbReference type="KEGG" id="cthr:CTHT_0066640"/>
    <dbReference type="eggNOG" id="ENOG502RMNF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_580009_0_0_1"/>
    <dbReference type="OMA" id="GMVHILN"/>
    <dbReference type="OrthoDB" id="5183255at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="471" mass="51142" checksum="C63A947EA3FD0039" modified="2011-10-19" version="1">MRDNSIRLNLVLGSVLEGRALKTLTDIAKASAEPDALWDQLQTLIASRRRLDMTKTELSNLGIEDTELTDIDRNIGDLNKTIVELGKQYAQKKLEAENQIRDLQSKISSVHADVESPIDYVQTAIKQMPLAADTLNLDVQYFSLDSNKQDAFTFVQQVGDYVASTFSWLGQEVATQISHAASTQVSSQTSKHTIIGTLVITASCSHKTSKVLAPLVIDVNKAIGVWNTLFPDDSIPSTSMSLEDAYHLIKKASANTDGKENNKFTIISGMTMGSCFVGMVHILNTSSTAAQEIMQDVKQTLQVQAQMDAASWFAKMSGGFGADFNLAESVKSLFSTQNIQSHVTLACLGVIPSIVSNEVQLSVEGFSKFDPASSMEALSILDSSTAAQADSIKGAAEAARKGQEMVTLKTSTMKAALTALGEIDDGRNKVLDINSMMTAFEDYLRKVAEGDSGIPVNYYTKDYTKDVILKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGT8</accession>
    <name>G0SGT8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED6</name>
        <name evidence="10" type="ORF">CTHT_0067530</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Mol. Cell" volume="81" first="1781" last="1788.e4">
            <title>Mediator structure and conformation change.</title>
            <authorList>
                <person name="Zhang H."/>
                <person name="Chen D.H."/>
                <person name="Mattoo R.U.H."/>
                <person name="Bushnell D.A."/>
                <person name="Wang Y."/>
                <person name="Yuan C."/>
                <person name="Wang L."/>
                <person name="Wang C."/>
                <person name="Davis R.E."/>
                <person name="Nie Y."/>
                <person name="Kornberg R.D."/>
            </authorList>
            <dbReference type="PubMed" id="33571424"/>
            <dbReference type="DOI" id="10.1016/j.molcel.2021.01.022"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (4.20 ANGSTROMS)</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 6 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697045.1">
        <property type="nucleotide sequence ID" value="XM_006696982.1"/>
    </dbReference>
    <dbReference type="PDB" id="6XP5">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.20 A"/>
        <property type="chains" value="F=1-336"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGT8"/>
    <dbReference type="EMDB" id="EMD-22284"/>
    <dbReference type="SMR" id="G0SGT8"/>
    <dbReference type="STRING" id="759272.G0SGT8"/>
    <dbReference type="GeneID" id="18260791"/>
    <dbReference type="KEGG" id="cthr:CTHT_0067530"/>
    <dbReference type="eggNOG" id="KOG3169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060172_0_0_1"/>
    <dbReference type="OMA" id="ASHGHTY"/>
    <dbReference type="OrthoDB" id="344220at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.580">
        <property type="entry name" value="Mediator complex, subunit Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007018">
        <property type="entry name" value="Mediator_Med6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038566">
        <property type="entry name" value="Mediator_Med6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13104">
        <property type="entry name" value="MED-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04934">
        <property type="entry name" value="Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="12" id="KW-0002">3D-structure</keyword>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="168"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="259"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="181"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS17427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="6XP5"/>
        </source>
    </evidence>
    <sequence length="336" mass="36312" checksum="49E89CB9C1C7F481" modified="2011-10-19" version="1">MADPSSSTSAMPLDEIQWHTNPAVVGGSIHDNSVLFYFRESPFYDKTSNNEVLYQQGLHNQTMMQFLETRERFERRLREMSGLEFVVAQEPAETAPGTGTGVWVINKQTRRKRQGEEDEISVHGTYFLVGENVYMAPTLADIISMRLASASSSISRLLPIAASVQSWSPGTGRVYKTPSMTSQTNQANQPSSQTQSQPTSQPATTTTTTALPPPDPRWLEETLMIHETFGDHHLDKNPITGKPGDFHLSSTGRKIQTLPTAAAGNKKPGSGLPPLPAINTKVQQNPMGSGKQVTGKETKSPKTPSSSTGPGTGGMSTGMGKPKKRKSSKAAVTPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGZ0</accession>
    <name>G0SGZ0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative nitroreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0068060</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nitroreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697097.1">
        <property type="nucleotide sequence ID" value="XM_006697034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGZ0"/>
    <dbReference type="STRING" id="759272.G0SGZ0"/>
    <dbReference type="GeneID" id="18260844"/>
    <dbReference type="KEGG" id="cthr:CTHT_0068060"/>
    <dbReference type="eggNOG" id="ENOG502RYI9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073125_1_0_1"/>
    <dbReference type="OMA" id="EMFENHT"/>
    <dbReference type="OrthoDB" id="2138173at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02140">
        <property type="entry name" value="Frm2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.109.10:FF:000001">
        <property type="entry name" value="Nitroreductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="entry name" value="NADH Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033877">
        <property type="entry name" value="Frm2/Hbn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43035">
        <property type="entry name" value="FATTY ACID REPRESSION MUTANT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43035:SF1">
        <property type="entry name" value="FATTY ACID REPRESSION MUTANT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="FMN-dependent nitroreductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="7">
        <location>
            <begin position="14"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS17479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="206" mass="23039" checksum="495ED1DD02B136E2" modified="2011-10-19" version="1">MATSLNADTFLAHIKNRRSYYPLNKELPISTQRIQEIIGEAVQHVPSSFNSQSNRVVVLFGAEHEKFWDLTTEVLKAIVPAEQWEPTGQKMAMFRGAAGTALFFEDQEVVEGLQAKFALYADRFPIWASHSTAMLQFAVWTALEAEGLGANLQHYNPLVDQKVQETWKVPASWKLSAQLVFGGKAVPDAGEKTFQPLEQKLKVYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0SH46</accession>
    <name>G0SH46_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Manganese lipoxygenase</fullName>
            <ecNumber evidence="3">1.13.11.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0068660</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(9Z,12Z)-octadecadienoate + O2 = (11S)-hydroperoxy-(9Z,12Z)-octadecadienoate</text>
            <dbReference type="Rhea" id="RHEA:18993"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:57467"/>
            <dbReference type="EC" id="1.13.11.45"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.13.11.45" evidence="3"/>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697153.1">
        <property type="nucleotide sequence ID" value="XM_006697090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SH46"/>
    <dbReference type="STRING" id="759272.G0SH46"/>
    <dbReference type="GeneID" id="18260904"/>
    <dbReference type="KEGG" id="cthr:CTHT_0068660"/>
    <dbReference type="eggNOG" id="ENOG502QVKD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009802_0_0_1"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050584">
        <property type="term" value="F:linoleate 11-lipoxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043651">
        <property type="term" value="P:linoleic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034440">
        <property type="term" value="P:lipid oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.245.10">
        <property type="entry name" value="Lipoxygenase-1, Domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000907">
        <property type="entry name" value="LipOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013819">
        <property type="entry name" value="LipOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036226">
        <property type="entry name" value="LipOase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11771">
        <property type="entry name" value="LIPOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00305">
        <property type="entry name" value="Lipoxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00087">
        <property type="entry name" value="LIPOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48484">
        <property type="entry name" value="Lipoxigenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51393">
        <property type="entry name" value="LIPOXYGENASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoxygenase" evidence="9">
        <location>
            <begin position="599"/>
            <end position="1093"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS17535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1093" mass="124540" checksum="3C7E4FA2684AE261" modified="2011-10-19" version="1">MTLSISSQAYCQQSQSKPRCPAQASITAAPQVNQQLASPIFGKLPAELRFIILSELFGERRVHLAFMPHPTRSDKVGNMRRWRHGLCEEPVSTPLRRLVSRPHFCLSSARHRVLDVAFMFTCRRALMESIPILYQSNCFFISNTGNKRLPVDDIRSLQAKMPKHWPLIKSLDIEWVCSYDRNHASMVPHLRGRESYEDFWDALAEMPSLTKLRIALIVPWYSCMDHHAPSPAEMQELYLGPMTRPRNLEVCEVLMHSSLAPFLGLQQIEWLRKQEPRCQYRISWIDEMPGQEPRGPAAAVLPHLLGMFGPRWAQNLSVPLPSSVRMVALSARSNDLDSETLPLVRTAIRSFSDKAVLDPNLPTPPSKLLANFPTMRSILRHKDEKEYFADIAPEDIRDALLTSFDPGVFDMELLRAKLYAIIDPHNPSRVQLPEARIVEGSYLGTQLALTQAYSRIEQTFASLFDVLGIEPTLPKYRTLEEQRELYQFSSYPKNPDGSIAQYPPHLKYIPDDERVSLLRIFNPIGLAETQILLKRLTPDEDGIHGRTKNWLFEKARALAFGGQPEKGITIQDVVDYNKYHRKIGTDIMGGGNIGMLDDWYSDRRFAEQQFTGTNPTTIALASPQWIAKFREAAKAGNYTKWITALDKADPSSLFIQDGSYFREAAGTGNPTADLHYKPPGSGENWAVGSVSLFQMHRDGKLHPVAICIDYKGSMANSVTIFNKRMTPSDSTRNEKEDWPWRYAKTCAQVTDWMRHELAVHLTLSHFVEEAIIVATNRTLPMDHPVYRILYPHWYKTLSLNAAARATLVPQVIADLVGLTPDQCYKFLHHAYDTYDFVGSYIPNDLARRGFPNTLDALNADIRYKNYPYAKDILAFWNTLRTYVHTVLSHFYPTDKAVAEDGCIQSWVAEIRTAASIPTFPEIGELTALVDAVTMCIHIASPFHTAVNYLQNFYHMFVAAKPPALCSRPPQTLDQLRNYTERDLVAALPINRQRMWLLAAQVPWLLSFRVEPERSLLNYAASEWRMCRDALRRHGEEANQQRDEALVRQRASERLYKELRELQKIVYRNSTAMDKGSVPYLVLDPGLTAVSILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0SH77</accession>
    <name>G0SH77_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0069010</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697184.1">
        <property type="nucleotide sequence ID" value="XM_006697121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SH77"/>
    <dbReference type="STRING" id="759272.G0SH77"/>
    <dbReference type="GeneID" id="18260939"/>
    <dbReference type="KEGG" id="cthr:CTHT_0069010"/>
    <dbReference type="eggNOG" id="KOG1118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034817_1_0_1"/>
    <dbReference type="OMA" id="KSMTSYV"/>
    <dbReference type="OrthoDB" id="14167at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="2">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="378" mass="41957" checksum="0927FA80DF5DED28" modified="2011-10-19" version="1">MSEEFKMLEAEMALRLDGTERLQRSMSQYVKWMGKRLESSEDKAYPIGYLGHMMAARKKLESRRLAYDASISRLQKSKKDDFKLEEELRSAKAKYDEASEDVSRRMQDIQSAEVDSIRDLSRFLDAELDYHERCALELRRLRQHWPSVSNTGSSPGEELLVNYSRSQSRPTRIIRSNTYSGTSKDIESVAPPVRMPTRPGASQIRIQLPQVDGPGPSIVPSKTSSFLGEVNFDREGERQQGFQSFSRTSLPTSTTTSISNLPSVSNLRGQLRRVNLSQTANQIGRDDDVTSISDSGSNPTSNDRQASNIGARTATTSESLSLMPSGRTPGQLARPADNAAASPFANESTIRKTPPPPPPSRSKKPTPPVPPKRRDLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHB2</accession>
    <name>G0SHB2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0069390</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697219.1">
        <property type="nucleotide sequence ID" value="XM_006697156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHB2"/>
    <dbReference type="GeneID" id="18260977"/>
    <dbReference type="KEGG" id="cthr:CTHT_0069390"/>
    <dbReference type="eggNOG" id="KOG4157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016905_1_0_1"/>
    <dbReference type="OMA" id="VAECKGN"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051589">
        <property type="entry name" value="Sialate-O-sulfotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964:SF5">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409247" description="WSC domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="36"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="140"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="249"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="249"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS17601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="579" mass="62748" checksum="E40D6BB3CC7EA47A" modified="2011-10-19" version="1">MPALRSMAAAMAAAALVGHSYATEVSLPPCLDPFKPFVYAGCYKDLGNPQLLPYRSSAPSEDMTVEKCVAECKGNGYRYAGLVYYGICYCGATVRGPEADESECSFPCNGDKSENCGGNNHFSVWQDPTFQATEEVTIEHYDPIGCWTDDSPYGRALVYKQDHIPSSEMTTEKCLQACRDGGFPFAGTEYSGECWCGVVIGNGTHAAPESECNMPCHGDNSQTCGGPSRLSLYAADELLSLEPCGYVPPAESSSSSTAAPSSTSTEAPEPSSTFPPEETSSTVEEPTTTPEPTTTPPPTTSKSSTTTSTTSSVCTTTTVIPPTCEYKCGKWCSNPLPDWKDQKTCSQAWASCTLQIASCFLTASWPDVLDCFDFSEWCSDVSRACGKIHHKHDFIKQHPPKGGNPAVTKTITVPCATPTSTKTSSTSTSTVVPTPTNICTQPSNPVGGIPFPIVTCNDVSKDWPTYPFKKFDHPDTKMCKRYQRNKVSTACADACKDQYEDCIKVYAEGCRQKKNTGPRDLLAVSSNSQQLGSLGKRTFYQWTDDYMTAVRKCEKQLSDCLKLNNKIDGNKKCPSFGHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHN4</accession>
    <name>G0SHN4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0070660</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697341.1">
        <property type="nucleotide sequence ID" value="XM_006697278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHN4"/>
    <dbReference type="STRING" id="759272.G0SHN4"/>
    <dbReference type="GeneID" id="18261104"/>
    <dbReference type="KEGG" id="cthr:CTHT_0070660"/>
    <dbReference type="eggNOG" id="ENOG502SDCM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058482_0_0_1"/>
    <dbReference type="OMA" id="HIQWADT"/>
    <dbReference type="OrthoDB" id="5431245at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037738">
        <property type="entry name" value="Ecm13-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36826">
        <property type="entry name" value="PROTEIN ECM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36826:SF1">
        <property type="entry name" value="PROTEIN ECM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="323" mass="35585" checksum="B89E31B03C556984" modified="2011-10-19" version="1">MSSPIPPASSPRYAPHARPLGSSPAPSSPQTPSSPFFARPRTNSFYRRNKMSIAQTYFLAHKARAKLSSEAARPNHNLRLLVGHANLLDSLMLELADAERQQESWFNESVRGASSYNSSDDSTSSEERHVQWADTIIEEPEHDWCAEDAESDSDSASDDSEISYDEDDYDEEDIEMADAVPLCRVPSHSSTHHLAYPTSTSDDYDMSSDSDEYDEYDEDEEEEDIAGLALRRSPSRSVLPSSSTPPELLDDSSDDSTEDEAMPPSPPTTVIATFEDAAEKHDTTTEDAEEPDAVPDEEKAAPPVYYIPTRARPGGLVSAISVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHT5</accession>
    <name>G0SHT5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0073300</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697587.1">
        <property type="nucleotide sequence ID" value="XM_006697524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHT5"/>
    <dbReference type="GeneID" id="18261368"/>
    <dbReference type="KEGG" id="cthr:CTHT_0073300"/>
    <dbReference type="eggNOG" id="ENOG502S6JZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069672_1_0_1"/>
    <dbReference type="OMA" id="CEIKWAP"/>
    <dbReference type="OrthoDB" id="2260257at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052982">
        <property type="entry name" value="SRP1/TIP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633:SF1">
        <property type="entry name" value="GPI ANCHORED SERINE-THREONINE RICH PROTEIN (AFU_ORTHOLOGUE AFUA_1G03630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409592" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="3">
        <location>
            <begin position="27"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS17005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="238" mass="24359" checksum="E15584A1E9FCF742" modified="2011-10-19" version="1">MKFSLASVLALAAAAFAQIDGFHPIYTPKKDEQVVAGTTYKIVWDYNPKYEGTIAIDLLGGSSPSTLTVVDAIAAGVDGSLNEYDWEVPADFGDLATYGIMITLESDKSIFQYGFPFKIVQKGGSSSDDDEPAATTSGAVITSTTAAAATSTAVSTKLSTAANTTTFTTVTSSTLSSLRGNWSTTVASPTTVVTEAITTTASATETEETDAAQTGGAKQLAASSLALFGGLAAAILAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHU9</accession>
    <name>G0SHU9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0073450</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697601.1">
        <property type="nucleotide sequence ID" value="XM_006697538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHU9"/>
    <dbReference type="GeneID" id="18261383"/>
    <dbReference type="KEGG" id="cthr:CTHT_0073450"/>
    <dbReference type="eggNOG" id="ENOG502QSKG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_0_2_1"/>
    <dbReference type="OMA" id="WTWNEDS"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="40591" checksum="70B78960473D5E2C" modified="2011-10-19" version="1">MGEKAEGTSTASPKTEESSVPGILPASHWQKTKLPDVPDDDADSTLSSTLWSETTSLASSIRRYRVLHGRTYHGEIGDAESWEPNDDKHAESMDLFHIMNTLVLGDKLFLAPVNNPKKVLDIGTGTGAWAIDFGDLYPNAEVIGTDITPIQPTWVPPNVRFEIEDCNQTWAREDNSFDFIHARTLVGNILDWGKFFREAYRCLKPGGWLENQETEMCWKAVNAEIPETSAMGQWHKVWHAGGEKSGRTFRLVEDNLQEKLMKEAGFVDIQVKDVLCPYGPWPEDPREKEAGIVTKAAFENDMDGYVLHIWHSVLGWTHEEVQVYLAHLRREIRDPRYKLYFTRRIVIGRKPLQQALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHW9</accession>
    <name>G0SHW9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0073650</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697621.1">
        <property type="nucleotide sequence ID" value="XM_006697558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHW9"/>
    <dbReference type="STRING" id="759272.G0SHW9"/>
    <dbReference type="GeneID" id="18261403"/>
    <dbReference type="KEGG" id="cthr:CTHT_0073650"/>
    <dbReference type="eggNOG" id="ENOG502QPI0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_390793_0_0_1"/>
    <dbReference type="OrthoDB" id="9999821at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="634"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="566"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="706" mass="77006" checksum="410F691AE086CDAF" modified="2011-10-19" version="1">MSAPYWGNLSPSGQGQTKARRSSLLDDQVASRERPSSLDASAEGRSRSNRFSIQTTKSDAPTDSTLSPFASPTASSFTPTGLTPRPPSLPYGATQYPPELLENRRRRRSQGHEQDESYASIAGKPPPAAPDVPRTVPSFNYPPVGSRRQPSQSSASYSGSDQYHRKMAAEEHLRTSQQLAVDKTRHSHNDPAVPRSHRVPTDHSLAAMDAAPANGGRQQRRTSAAEQSLHLSSRRTSAQRPKAVADRSPLQQLESALDSISKEDKRARVEAAERAARERAAAAAAATTTAANGAIQREENASQGGRARARRSSMSAKDAPPAASDQTVGIRRNLSFRERAARNDIKLPDALEDVATTTPPGRRQRRAKKYQGDPWPRRVSDPESIFNADDLPAQSQSTQRTFNDSLDGESLRDEDLLAYPASGKITRTPSQKKADQILGRGVDVPAPSAHNAPRQGQHNVLRKPMPPSAAAANPPPHGPANDRVEHAPETHQRAEEHHQISEADFSAREQLLRPGQGMYKPKPYLEEWKHATVGALTGALIDIDNEVIQNPSGQHGSRRDAASLQRRSNNTSTSVSVSVRPRKGEAYAGEYDERVNGMRPPTAQAIYPSIAEVQNGEFRFPSQSDLSVRSGLPFEPQHLAAAPRKSKGRSKRWDDLRPLSPSPPGASDSTDSLECFSLRSNDATLSRQTLIYSRTFYPSPPQILCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>G0SI25</accession>
    <name>G0SI25_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0074240</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697677.1">
        <property type="nucleotide sequence ID" value="XM_006697614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SI25"/>
    <dbReference type="GeneID" id="18261462"/>
    <dbReference type="KEGG" id="cthr:CTHT_0074240"/>
    <dbReference type="HOGENOM" id="CLU_2346505_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="97" mass="10590" checksum="2A40D6842DA8756A" modified="2011-10-19" version="1">MDGLGVNFKKAVEGQASINRVASPIVTSSAVESAIFCTIDLNFLYVVGWFGFLYSNVTMEPSVIIIIFIILVDFKPGTRLVIKSARLSRIISFTATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYD7</accession>
    <name>G0RYD7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial zinc maintenance protein 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0006320</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Assembly factor required for Rieske Fe-S protein RIP1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane. Modulates the mitochondrial matrix zinc pool.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with RIP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family. MZM1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691165.1">
        <property type="nucleotide sequence ID" value="XM_006691102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYD7"/>
    <dbReference type="STRING" id="759272.G0RYD7"/>
    <dbReference type="GeneID" id="18254670"/>
    <dbReference type="KEGG" id="cthr:CTHT_0006320"/>
    <dbReference type="eggNOG" id="ENOG502S6EF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147114_2_2_1"/>
    <dbReference type="OMA" id="KYKLRIH"/>
    <dbReference type="OrthoDB" id="529194at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20267">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045298">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050435">
        <property type="entry name" value="MZM1/LYRM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46749">
        <property type="entry name" value="COMPLEX III ASSEMBLY FACTOR LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46749:SF1">
        <property type="entry name" value="COMPLEX III ASSEMBLY FACTOR LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="10">
        <location>
            <begin position="4"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="82"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS23923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="113" mass="12766" checksum="AA421CD0ABF668C1" modified="2011-10-19" version="1">MSAAIHAYRHLLRAARIAFDGDTRVLEAARQQIRQGFREKASLPADDPSIGPAIQHAEEVAQFLKTNLVQGRKEGDVYKLRIHEHTERGDNDSVKKPKNNSKTDPNFKCCSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYE1</accession>
    <name>G0RYE1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0006360</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691169.1">
        <property type="nucleotide sequence ID" value="XM_006691106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYE1"/>
    <dbReference type="GeneID" id="18254674"/>
    <dbReference type="KEGG" id="cthr:CTHT_0006360"/>
    <dbReference type="HOGENOM" id="CLU_866254_0_0_1"/>
    <dbReference type="OMA" id="FAETWAN"/>
    <dbReference type="OrthoDB" id="4586433at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="335" mass="35491" checksum="6698981F67E0B557" modified="2011-10-19" version="1">MSTPPQAFHSSEPRKPGFNTLSFPAPASRSAQQYVETSPNPPPEFVATGPEYFTESSQITGANSSPPPSHQHQTPTTATVPNPHDSYLPEIDTTAKAANCTTSPTAMRQHVWDDPPKMPWYRRISSVGWLIITITFLGISGVVLAILGAMGFFTGHHRSGDSSSLSDYTTIISVSSLTSAQAEVTNPAASGAGDSSDMEGDAQMTATSMMISTTANDTSPLTITHPLCTNSSDFLTNITWLGSGPQLYDTLYDPPASSAAECCQLCADNAAPEFTPQGPGSGCTGWLFNDKSPWTPCTRLVVQTEKQGAKKGKTCPKGYADETKFVKAGKGEVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYG4</accession>
    <name>G0RYG4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="16">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CTHT_0006600</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="23 24" key="2">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e56910" last="e56910">
            <title>Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation during pre-60S biogenesis.</title>
            <authorList>
                <person name="Lau B."/>
                <person name="Huang Z."/>
                <person name="Kellner N."/>
                <person name="Niu S."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
                <person name="Cheng J."/>
            </authorList>
            <dbReference type="PubMed" id="37129998"/>
            <dbReference type="DOI" id="10.15252/embr.202356910"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS) IN COMPLEX WITH ADP</scope>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.</text>
    </comment>
    <comment type="function">
        <text evidence="16">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of pre-60S ribosomal complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="16">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="16"/>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691192.1">
        <property type="nucleotide sequence ID" value="XM_006691129.1"/>
    </dbReference>
    <dbReference type="PDB" id="8I9Z">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="CW=1-679"/>
    </dbReference>
    <dbReference type="PDB" id="8IA0">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="CW=1-679"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYG4"/>
    <dbReference type="EMDB" id="EMD-35289"/>
    <dbReference type="EMDB" id="EMD-35290"/>
    <dbReference type="SMR" id="G0RYG4"/>
    <dbReference type="STRING" id="759272.G0RYG4"/>
    <dbReference type="GeneID" id="18254698"/>
    <dbReference type="KEGG" id="cthr:CTHT_0006600"/>
    <dbReference type="eggNOG" id="KOG0345">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_26_4_1"/>
    <dbReference type="OMA" id="AYKEHEC"/>
    <dbReference type="OrthoDB" id="7396459at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17960">
        <property type="entry name" value="DEADc_DDX55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056330">
        <property type="entry name" value="CTT_SPB4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23681">
        <property type="entry name" value="CTT_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
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    <sequence length="679" mass="75353" checksum="1135A8456973EC58" modified="2011-10-19" version="1">MAPEQARSKKSSRSWTAFNPPLPQWILDYVSSMGYEQPTPVQKSCLDIFRGNKDVVVEAVTGSGKTLAFLIPVVERLLRLDEAAKKHHVQAIIISPTRELASQIYNVLVSLIKFHPESSELLQYAKSDEKRPATTKPVIVPQLLVGGTVKAAEDLSIFLRLSPNLLVGTPGRLAELLSSPYVKTPASSFEVLVMDEADRLLDLGFSPELTRILGYLPKQRRTGLFSASLSDAVERLITVGMLYPHKITVRVKSLKTGGVIEERKTPMSLQMSYIVTPASHKIPALCQILEKLDPRPQRSIVFFSTCFAVKYFARVLHGILPAGYSIVSLHGKLEPHVREKNYERFVTATSPTVLLTTDIAARGLDIPQVDLVIQHDPPTDTKVFIHRCGRAGRAGRRGLSVVMLQPGREEGYVQLLEVRQTPITPLEHPQISVTDTQADDVANKIREQAKKDREVFQLAQRAFVSWARSYMEHQATSIFRVADLDWFDLAKGYGLLELPKMPETRGLDRSLGLGIDTSAIPFKDKAREKKRLAELEKWKAEKAEKEAAAAAAGETAGADGSNPLKRKKNEAWSGKHEQEELRQLRKEKKRRKKEALKMARMTEKEKEELRKLEELINEVRKRNQQAAAGTANGQPMKEGGSSSSSSSSSSSSNGTESKGGGKESKGGADEESEFEGFDD</sequence>
</entry>
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        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
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                <person name="Hurt E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
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                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
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            <dbReference type="PubMed" id="21784248"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
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    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2023" name="Nat. Commun." volume="14" first="7355" last="7355">
            <title>The GET insertase exhibits conformational plasticity and induces membrane thinning.</title>
            <authorList>
                <person name="McDowell M.A."/>
                <person name="Heimes M."/>
                <person name="Enkavi G."/>
                <person name="Farkas A."/>
                <person name="Saar D."/>
                <person name="Wild K."/>
                <person name="Schwappach B."/>
                <person name="Vattulainen I."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="37963916"/>
            <dbReference type="DOI" id="10.1038/s41467-023-42867-2"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (4.70 ANGSTROMS) OF 185-357</scope>
    </reference>
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        <property type="protein sequence ID" value="EGS23572.1"/>
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    <dbReference type="KEGG" id="cthr:CTHT_0002670"/>
    <dbReference type="eggNOG" id="ENOG502S1RY">
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
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        <property type="entry name" value="Get2/sif1"/>
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        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 2"/>
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        <location>
            <begin position="189"/>
            <end position="211"/>
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    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="252"/>
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        <location>
            <begin position="338"/>
            <end position="355"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS23572.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
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    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="8ODV"/>
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    <sequence length="357" mass="38528" checksum="AD90F8D1809C8DB0" modified="2011-10-19" version="1">MTELTPEQEAAALRAEEQARLRKARREAKIKAGAAHRLNTITGLASGIPRANTASSLDSNPTPVAPTAGPTIISSSIQKITTEPEEINLAQHFYRPGQSRTLSLPVTFETAASRLDMPPAGRRNPYTFGVNSKQMPPPAEEDPMLSLMSKILSPNAAVGGINSRPPFGPQSAQSQQNQMPILPPRPTPLWRFLHTLLAVALGLAVIMLSPFGGTKLERDRAAAAVAGSASEREWLASLTDSYPLVKTGLGGGLFWAFATGEAILLGTRWLFLSKKKKAATAAAKVNNNNGEGDDAELDSVEQAIELALEFFPAIRQPVEYLRPKVAVAMRYVDVGMTLWRDVMLALFVLGAVAWWRA</sequence>
</entry>
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    <accession>G0RZM9</accession>
    <name>G0RZM9_CHATD</name>
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        <submittedName>
            <fullName evidence="6">40S ribosomal protein S13-like protein</fullName>
        </submittedName>
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        <name evidence="6" type="ORF">CTHT_0003530</name>
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    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2017" name="Nat. Struct. Mol. Biol." volume="24" first="954" last="964">
            <title>3.2-A-resolution structure of the 90S preribosome before A1 pre-rRNA cleavage.</title>
            <authorList>
                <person name="Cheng J."/>
                <person name="Kellner N."/>
                <person name="Berninghausen O."/>
                <person name="Hurt E."/>
                <person name="Beckmann R."/>
            </authorList>
            <dbReference type="PubMed" id="28967883"/>
            <dbReference type="DOI" id="10.1038/nsmb.3476"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.20 ANGSTROMS)</scope>
    </reference>
    <reference evidence="9 10 11" key="3">
        <citation type="journal article" date="2019" name="Mol. Cell" volume="75" first="1256" last="1269.e7">
            <title>Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration.</title>
            <authorList>
                <person name="Cheng J."/>
                <person name="Bassler J."/>
                <person name="Fischer P."/>
                <person name="Lau B."/>
                <person name="Kellner N."/>
                <person name="Kunze R."/>
                <person name="Griesel S."/>
                <person name="Kallas M."/>
                <person name="Berninghausen O."/>
                <person name="Strauss D."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
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            <dbReference type="PubMed" id="31378463"/>
            <dbReference type="DOI" id="10.1016/j.molcel.2019.06.032"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.50 ANGSTROMS)</scope>
    </reference>
    <reference evidence="12 13" key="4">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="476" last="476">
            <title>High-resolution structures of a thermophilic eukaryotic 80S ribosome reveal atomistic details of translocation.</title>
            <authorList>
                <person name="Kisonaite M."/>
                <person name="Wild K."/>
                <person name="Lapouge K."/>
                <person name="Ruppert T."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="35079002"/>
            <dbReference type="DOI" id="10.1038/s41467-022-27967-9"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.90 ANGSTROMS)</scope>
    </reference>
    <reference evidence="14 15" key="5">
        <citation type="journal article" date="2023" name="Nat. Struct. Mol. Biol." volume="30" first="670" last="677">
            <title>Structural inventory of cotranslational protein folding by the eukaryotic RAC complex.</title>
            <authorList>
                <person name="Kisonaite M."/>
                <person name="Wild K."/>
                <person name="Lapouge K."/>
                <person name="Gese G.V."/>
                <person name="Kellner N."/>
                <person name="Hurt E."/>
                <person name="Sinning I."/>
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            <dbReference type="PubMed" id="37081320"/>
            <dbReference type="DOI" id="10.1038/s41594-023-00973-1"/>
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        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.20 ANGSTROMS)</scope>
    </reference>
    <reference evidence="16" key="6">
        <citation type="journal article" date="2024" name="Nat. Commun." volume="15" first="716" last="716">
            <title>Methionine aminopeptidase 2 and its autoproteolysis product have different binding sites on the ribosome.</title>
            <authorList>
                <person name="Klein M.A."/>
                <person name="Wild K."/>
                <person name="Kisonaite M."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="38267453"/>
            <dbReference type="DOI" id="10.1038/s41467-024-44862-7"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.10 ANGSTROMS)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EGS23657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="interactions" value="1"/>
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        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15"/>
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    <keyword evidence="8 9 10" id="KW-0002">3D-structure</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS15 N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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            <dbReference type="RuleBase" id="RU003919"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
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    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="7Z3N"/>
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    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="7Z3O"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="8OO0"/>
        </source>
    </evidence>
    <sequence length="151" mass="16881" checksum="86EA1A7D526EC310" modified="2011-10-19" version="1">MGRLHSKGKGISASAIPYSRNPPAWLKTTPEQVVEQICKLARKGATPSQIGVILRDSHGIAQVKVVTGNKILRILKSNGLAPDIPEDLYFLIKKAVAVRKHLERNRKDKDSKFRLILIESRIHRLARYYKTVGVLPPTWKYESSTASTLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZQ3</accession>
    <name>G0RZQ3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0003780</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690923.1">
        <property type="nucleotide sequence ID" value="XM_006690860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZQ3"/>
    <dbReference type="STRING" id="759272.G0RZQ3"/>
    <dbReference type="GeneID" id="18254416"/>
    <dbReference type="KEGG" id="cthr:CTHT_0003780"/>
    <dbReference type="eggNOG" id="KOG1371">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054225_0_0_1"/>
    <dbReference type="OMA" id="DRVYVNE"/>
    <dbReference type="OrthoDB" id="202470at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08946">
        <property type="entry name" value="SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43000">
        <property type="entry name" value="DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="2">
        <location>
            <begin position="7"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="359" mass="39188" checksum="BD26AE1AB85E43BE" modified="2011-10-19" version="1">MSMKPAVLVTGSSGHLGKALMLSLPELGYNPIGIDINSSNTTTHIGSITDPSFLSNVFSSYNIAHVIHAATLHKPHICSHSKAEFVQTNIAGTLALLEVASSSPNPSSPVKSFIYISTTSAFGTSLSPPEGSPAAWINDDTPTTSHKNIYGLTKSTAEDLCQLIAKEKGLPTVVLRTSRFFPEEDDDEARRAEVPDEENLKVLELAYRRVDVADVVSACVCAMERCAEGTIRWGKFIVSAPTPFGREDLDALSKDAEGVLRGLRVGVGVKVGEVFDLKRWKFLRRIDRVYDSSRAIRELGWRPEYTFERAVEKVAKGEEWKSELTRRIGRLGYHAVSVGVYTKRDDKEGGSGQHGAPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0S036</accession>
    <name>G0S036_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0008600</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691388.1">
        <property type="nucleotide sequence ID" value="XM_006691325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S036"/>
    <dbReference type="STRING" id="759272.G0S036"/>
    <dbReference type="GeneID" id="18254898"/>
    <dbReference type="KEGG" id="cthr:CTHT_0008600"/>
    <dbReference type="eggNOG" id="ENOG502S4J9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060150_0_0_1"/>
    <dbReference type="OMA" id="RWNDQYK"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="335" mass="33942" checksum="F53EB64365B2BE1E" modified="2011-10-19" version="1">MVDFQPPAGPPPPKVPEGWVVRWNEQYYVNIYTKVSQWEKPTEPARPPEPASEAPPPGPPPSYTGGNTSSPATDSKTSNNPFLSATNTGTTSTSNPTPSEEDDERLARQLQAEEDARAAAALAGYPPAGISTSTSAANATPSSSAFPTELPPRPGSSSANRGSSGKSGSGTKLLDKLLSKVAGSKHSKYHPPPPHPGPHPGPAGFFAAHPPPPPHPGPHGPPPPPGGFFTPPHGHGHPPEPHGPGFHGFHPPPPGGGFFGGHHPPGHVFGHGHGHHGGKSRGSGMGMAAGAAALGVGAGLVGGALVADAVMDAQMDAYQEGFADGADFGGGDFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0B1</accession>
    <name>G0S0B1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA 3'-terminal phosphate cyclase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0009390</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2017" name="Nat. Struct. Mol. Biol." volume="24" first="954" last="964">
            <title>3.2-A-resolution structure of the 90S preribosome before A1 pre-rRNA cleavage.</title>
            <authorList>
                <person name="Cheng J."/>
                <person name="Kellner N."/>
                <person name="Berninghausen O."/>
                <person name="Hurt E."/>
                <person name="Beckmann R."/>
            </authorList>
            <dbReference type="PubMed" id="28967883"/>
            <dbReference type="DOI" id="10.1038/nsmb.3476"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.20 ANGSTROMS)</scope>
    </reference>
    <reference evidence="10 11 12" key="3">
        <citation type="journal article" date="2019" name="Mol. Cell" volume="75" first="1256" last="1269.e7">
            <title>Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration.</title>
            <authorList>
                <person name="Cheng J."/>
                <person name="Bassler J."/>
                <person name="Fischer P."/>
                <person name="Lau B."/>
                <person name="Kellner N."/>
                <person name="Kunze R."/>
                <person name="Griesel S."/>
                <person name="Kallas M."/>
                <person name="Berninghausen O."/>
                <person name="Strauss D."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="31378463"/>
            <dbReference type="DOI" id="10.1016/j.molcel.2019.06.032"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.50 ANGSTROMS)</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691463.1">
        <property type="nucleotide sequence ID" value="XM_006691400.1"/>
    </dbReference>
    <dbReference type="PDB" id="5OQL">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="Y=1-411"/>
    </dbReference>
    <dbReference type="PDB" id="6RXT">
        <property type="method" value="EM"/>
        <property type="resolution" value="7.00 A"/>
        <property type="chains" value="CH=1-411"/>
    </dbReference>
    <dbReference type="PDB" id="6RXU">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.50 A"/>
        <property type="chains" value="CH=1-411"/>
    </dbReference>
    <dbReference type="PDB" id="6RXV">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.00 A"/>
        <property type="chains" value="CH=1-411"/>
    </dbReference>
    <dbReference type="PDB" id="6RXX">
        <property type="method" value="EM"/>
        <property type="resolution" value="7.10 A"/>
        <property type="chains" value="CH=1-411"/>
    </dbReference>
    <dbReference type="PDB" id="6RXY">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.70 A"/>
        <property type="chains" value="CH=1-411"/>
    </dbReference>
    <dbReference type="PDB" id="6RXZ">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.40 A"/>
        <property type="chains" value="CH=1-411"/>
    </dbReference>
    <dbReference type="PDBsum" id="5OQL"/>
    <dbReference type="PDBsum" id="6RXT"/>
    <dbReference type="PDBsum" id="6RXU"/>
    <dbReference type="PDBsum" id="6RXV"/>
    <dbReference type="PDBsum" id="6RXX"/>
    <dbReference type="PDBsum" id="6RXY"/>
    <dbReference type="PDBsum" id="6RXZ"/>
    <dbReference type="AlphaFoldDB" id="G0S0B1"/>
    <dbReference type="EMDB" id="EMD-10051"/>
    <dbReference type="EMDB" id="EMD-10052"/>
    <dbReference type="EMDB" id="EMD-10053"/>
    <dbReference type="EMDB" id="EMD-10054"/>
    <dbReference type="EMDB" id="EMD-10055"/>
    <dbReference type="EMDB" id="EMD-10056"/>
    <dbReference type="EMDB" id="EMD-3847"/>
    <dbReference type="SMR" id="G0S0B1"/>
    <dbReference type="IntAct" id="G0S0B1">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S0B1"/>
    <dbReference type="GeneID" id="18254977"/>
    <dbReference type="KEGG" id="cthr:CTHT_0009390"/>
    <dbReference type="eggNOG" id="KOG3980">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027882_1_0_1"/>
    <dbReference type="OMA" id="YTDQNKG"/>
    <dbReference type="OrthoDB" id="1911237at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00875">
        <property type="entry name" value="RNA_Cyclase_Class_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.20:FF:000004">
        <property type="entry name" value="18S rRNA biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013791">
        <property type="entry name" value="RNA3'-term_phos_cycl_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016443">
        <property type="entry name" value="RNA3'_term_phos_cyc_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03400">
        <property type="entry name" value="18S_RNA_Rcl1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF1">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05189">
        <property type="entry name" value="RTC_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9 10 11" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="5">
        <location>
            <begin position="10"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase insert" evidence="6">
        <location>
            <begin position="211"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS23272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="5OQL"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="6RXT"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="6RXU"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="6RXV"/>
        </source>
    </evidence>
    <sequence length="411" mass="43348" checksum="CFE93A3BE84B3F66" modified="2011-10-19" version="1">MAEPKPEFLRFTGHRAFTQRLVLATLYGRPIHISKIRSSSATNPGLAPHEISFLRLLESVTNGSIIDVSYSGTTITYQPGLITGTVPGMNASLSSDAIEHVIPATNTRGITYFLIPLALLAPFSKAHLNVRFTGPGVITSATHGARDLSIDTFRTAVLPLYGLFGIPPARIELRVLQRSCAGPGGKGGGGIVEMRFASQVRLPKTLHLNRRPGKVRRIRGVAYCTGVAASHNNRMITAARGVLNQLVSDVHIAAQYDPAPLVAEKGTTQKKKTGIGFGLSLVAETSAEGVIYAADEVAPPEGGVVPEDIGEKCAYQLLDVIAQGGCVMAASAPTVLTLMAMGSEDVGRLRLGRRVVSPELLELARDLKAFGAASWGIRDAGDDEDDAEGELGDLIVSVKGTGVGNVGRKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0K6</accession>
    <name>G0S0K6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0010350</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988038">
        <property type="protein sequence ID" value="EGS23124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691558.1">
        <property type="nucleotide sequence ID" value="XM_006691495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0K6"/>
    <dbReference type="GeneID" id="18255073"/>
    <dbReference type="KEGG" id="cthr:CTHT_0010350"/>
    <dbReference type="eggNOG" id="KOG2029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_363280_0_0_1"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="310"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="629" mass="71517" checksum="D89D19F09A6B6B8E" modified="2011-10-19" version="1">MNDRTTPHSSLSLSPFSSLLYILIQSKLIYYPLRLLYPTPPDPGLDDDDVPDNAEIDIIAVHGLNPRNKDDEEHAWDTWRTPPGEQGKLWLRDMLPKKVPNARIFLYQYNSSVVYSSDRRTFLDKANDFLEDVRLSRTNDPQRPLLLVGHSLGGLLIKQALINAYNNEVYSDIKMATKGLAFFATPHYGGRASLVRIGEVAAKIAKGLGFRKGDNIIHVLKDGTLFTNLVDELWKQRLLDYPIVSFWGSRDDVVSKEASTFGLPGKQERVVCLDADHNSICKFGDSQEDRDNWKKVRGNIVELCHDALSMDDQTVEQLIANLVKQLLSNKFPPPSSVTDAYTRHKKYKSQPSLSDLEGMFHAVAALYKDGVFVIVDALDECQMSDNIRSKFIEALLRLQSRKSNVNILATSRPVPDIVEAFDGYSRLEIVAQRDDIERYIRNKMPNLRAVSKYPHLQDEIIDCIASVADGMFLLAHLFFETLKDKVSAKLVRKTLKELQNDAKEKEPKHALLRRAYDDAMERINGQPVGYKKLAKHVLSWIICAKRPLQTIEVQYAWAVKDSEDELDKTAIPDAEDMLSIAELIHTDKTTRAESRYIGQQGMAIQMLLKLCYRMAESTQRGRIERAKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0L2</accession>
    <name>G0S0L2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TPR domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0010410</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691564.1">
        <property type="nucleotide sequence ID" value="XM_006691501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0L2"/>
    <dbReference type="STRING" id="759272.G0S0L2"/>
    <dbReference type="GeneID" id="18255079"/>
    <dbReference type="KEGG" id="cthr:CTHT_0010410"/>
    <dbReference type="eggNOG" id="ENOG502QU74">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011527_0_1_1"/>
    <dbReference type="OMA" id="LMEMSPT"/>
    <dbReference type="OrthoDB" id="414774at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45588">
        <property type="entry name" value="TPR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45588:SF1">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="577" mass="65450" checksum="70BDDB93BBA30AE3" modified="2011-10-19" version="1">MDIKVTATRSMHWVNTRQDADADGYYNLGDHYMPISTKSTEAQKWFNRGLVWVYGFNHEEAVKCFRRALDHDADCAMALWGVAYALGPNYNKTWGVFDPLELETSTREARQSIVKALEKSGPGSGVSDVERALIVALERRHPRETISVEDGYLLNKEYAEAMRMVYQSHPEHPDVTAIYVDALMNLSPWRLWDIRTGEPLPEGHALEAKKALDDSLKKHPRHPGMLHLYIHLMEMSTHPEEALHAADTLRALVPDAGHLNHMPTHIDVLCGDYRLAISSNTDAIVADEKFVARDGALNFYSLYRCHNYHFRVYAAMFAGQSRVALQTVDLLERTLSEDLLRTESPPMADWLEGFLSLRVHVLIRFGLWHDLIGLKLPDDQDLYCNTTAMIHYGKGVAFANVGMIKEAEESRRLFHEAVKKVPESRTIFNNTCLSILAIASTMLDGELEYRKGNIEEGLAHLRHAITLDDNLPYDEPWGWMQPTRHAYGALLLEQGRLKEALAVYAADLGFDESLPRALQHRNNVWALHGFHECLLRLNREEEARLIRPQLQLAIAAADVPVNASCFCRRVPQAACDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0T8</accession>
    <name>G0S0T8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peroxisomal membrane protein PEX16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0011200</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peroxin-16 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691640.1">
        <property type="nucleotide sequence ID" value="XM_006691577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0T8"/>
    <dbReference type="STRING" id="759272.G0S0T8"/>
    <dbReference type="GeneID" id="18255158"/>
    <dbReference type="KEGG" id="cthr:CTHT_0011200"/>
    <dbReference type="eggNOG" id="KOG4546">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036533_1_0_1"/>
    <dbReference type="OMA" id="PTWQSTY"/>
    <dbReference type="OrthoDB" id="2021143at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013919">
        <property type="entry name" value="Pex16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13299">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13299:SF0">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08610">
        <property type="entry name" value="Pex16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="2" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU365003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS22648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="425" mass="47787" checksum="54C45291789D31B3" modified="2011-10-19" version="1">MSTASSRAIQAHGPGKPKESGFLHAVSAPARWLNTYDDFITKNSHQVSQIESTLRSLTYIIPGRFRDAEIASESIHSGVQLLSLYHDTLLRKAQSLSKIPVPPLPRSSSLHNRYTRYWTLKSPLYRRVAYVLQIVSYVELLCEMAAKKRGERTRWRVVILLEAVKAVCKLLLLRITRSRPLVSPALPEREPIPEQPSEEEDSFDDFLAGFEEDDEDRRQIASNIQSNSAGLVVEQKTPPQLGPHGEWTMPRTGMTLPPLPAPGDITSYLLSRVLTADDIKPAAKLVNRLQGPAALTAEVLHILAPVVFAVAMARYHLAKRAQGGTKATGKTGALAAWAPWVWGIACEMVARQLRDRGLRTTPLEREEWSRRGWALAWWAMRGAFYDNVTKGLIEGVRRRMPGFVAGIIEDYEYLWENYYFSTSND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G0S143</accession>
    <name>G0S143_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Importin-95</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Karyopherin-95</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0012280</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2016" name="Acta Crystallogr. D Struct. Biol." volume="72" first="705" last="717">
            <title>Impact of the crystallization condition on importin-beta conformation.</title>
            <authorList>
                <person name="Tauchert M.J."/>
                <person name="Hemonnot C."/>
                <person name="Neumann P."/>
                <person name="Koster S."/>
                <person name="Ficner R."/>
                <person name="Dickmanns A."/>
            </authorList>
            <dbReference type="PubMed" id="27303791"/>
            <dbReference type="DOI" id="10.1107/s2059798316004940"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS)</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family. Importin beta-1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691745.1">
        <property type="nucleotide sequence ID" value="XM_006691682.1"/>
    </dbReference>
    <dbReference type="PDB" id="4XRI">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.05 A"/>
        <property type="chains" value="A=1-877"/>
    </dbReference>
    <dbReference type="PDB" id="4XRK">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.25 A"/>
        <property type="chains" value="A=1-877"/>
    </dbReference>
    <dbReference type="PDBsum" id="4XRI"/>
    <dbReference type="PDBsum" id="4XRK"/>
    <dbReference type="AlphaFoldDB" id="G0S143"/>
    <dbReference type="SMR" id="G0S143"/>
    <dbReference type="STRING" id="759272.G0S143"/>
    <dbReference type="GeneID" id="18255266"/>
    <dbReference type="KEGG" id="cthr:CTHT_0012280"/>
    <dbReference type="eggNOG" id="KOG1241">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008296_1_0_1"/>
    <dbReference type="OMA" id="QQYQERW"/>
    <dbReference type="OrthoDB" id="10263328at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000027">
        <property type="entry name" value="Importin subunit beta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="12 13" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="25"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00079884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS22753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="4XRI"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="4XRK"/>
        </source>
    </evidence>
    <sequence length="877" mass="96162" checksum="C4828CC058FF6173" modified="2011-10-19" version="1">MEGAPDINIILENSLSPDATLRHAAEQQLTHAAETNFSQYLLTLVQALANESSEGHIRAAAGIALKNAFSAREFARQAALQAKWLNQTDQETRTRVKQLALETLASSNSKAGQAAAQVIAAIAAIELPRNQWPELMHALVRNVSEGGQHQKQASLTAIGFICETQDTDLRNSLVGHSNAILTAVVQGARKEEPNNEVRFAAITALGDSLEFVGNNFKHEGERNYIMQVVCEATQAQDSRIQQGAFGCLNRIMALYYEHMRYYMEKALFGLTILGMKSDDEDVAKLAVEFWSTVCEEEIAIEDDNAQVESSEQMRPFYNFARVATNEVVPVLLQLLTKQDEDASDDEYNISRAAYQCLQLYAQAVGSTIIPPVIQFVEHNLRHADWHFRDAAVSAFGAIMDGPEEKVLEPIVKTGMQPLIAMMEDESIQVRDSTAYALGRITEACSEAIDPNTHLEPLIRSLFNGLMNSPKMAASCCWALMNIAERFAGEPGAAQNPLTPHFNQSVTNLLTVTAPMNGDSTVRTAAYEVLSVFVQNAANDSLSAVASLSTVILQRLEETLPLQQQVVSVEDKLILEDMQTSLCTVLQATVQRLDKEIAPQGDRIMQVLLQILSTCGGKSSVPEGVFAAISALANAMEEEFAKYMEAFAPFLYNALGNQEEPSLCSMAIGLVSDVTRSLGERSQPYCDNFMNYLLGNLRSTTLANQFKPAILQCFGDIASAIGGHFETYLTIVAQVLQQAATITAGPDGSYEMIDYVISLREGIMDAWGGIIGAMKTSNKTNVLQPYVESIFALLNSIANDPNRSEALMRASMGVIGDLADAYPNGQLADAFRQDWITAMIRETRSNREFGARTIETARWAREQVKRQIAGSQTVMQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G0S192</accession>
    <name>G0S192_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0012770</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691794.1">
        <property type="nucleotide sequence ID" value="XM_006691731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S192"/>
    <dbReference type="STRING" id="759272.G0S192"/>
    <dbReference type="GeneID" id="18255315"/>
    <dbReference type="KEGG" id="cthr:CTHT_0012770"/>
    <dbReference type="eggNOG" id="KOG0605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_67_4_1"/>
    <dbReference type="OMA" id="KLRVDQF"/>
    <dbReference type="OrthoDB" id="18472at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21776">
        <property type="entry name" value="MobB_Sid2p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05600">
        <property type="entry name" value="STKc_Sid2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000141">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000319">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000109">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF417">
        <property type="entry name" value="CELL CYCLE PROTEIN KINASE DBF2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="259"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="563"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="110"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="635"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="650"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS22802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="661" mass="76121" checksum="5719DD6650E38807" modified="2011-10-19" version="1">MASFMANLFPGGRDKADARPSTPVRSTANYSFTTPASTPQGSPSKKTVPPGARELPSAFQSLKLNQQSAFDSPVKLGRPQSVIAPLSPGKSNIQAFEEGHAVDDSVLRKGATHNRARSPQRNHGQENTPPVLPRDPFTEPTYQPSHAAVSRQEFYQHRERPSTRRFNTQRGLTPEERELLNKPNVKRLVNVTQLYFLDYYFDLLTYVSARQKRLAAFKQEFPPPPATDEETYKQMWTKYTGRERANLRKRRVRLKHADFQILTQVGQGGYGQVFLAQKKDTKEVCALKVMNKKLLFKLDEVRHVLTERDILTTAKSEWLVRLLYSFQDETNIYLAMEYVPGGDFRTLLNNTGVLSNRHARFYIAEMFCAVDALHQLGYIHRDLKPENFLVDSTGHVKLTDFGLAAGFLAPSRLESMRLRLEQASQAPVPFGKPIGERTVAERREGYRNMREREINYAKSIVGSPDYMAPEVLRGEEYDFTVDYWSLGCMLFEALTGFPPFAGATADETWRNLNHWKEVLKRPVWEDPNYFLSNRTWNFITTCINSRSRRFNNINDIYNHQYFAEVNWKHLRETKPPFVPELDSETDAGYFDDFSNEADMAKYKEVHEKQQALEKMADRTEEMSKSLFVGFTFRHRKPATDEPTPRKPIPFDDDDEDFGTML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1D6</accession>
    <name>G0S1D6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0013220</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EGS22846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006691775.1"/>
    </dbReference>
    <dbReference type="GeneID" id="18255360"/>
    <dbReference type="KEGG" id="cthr:CTHT_0013220"/>
    <dbReference type="HOGENOM" id="CLU_243184_0_0_1"/>
    <dbReference type="OrthoDB" id="4588465at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF40">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1350"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1379"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1404"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1503"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="335"/>
            <end position="360"/>
        </location>
    </feature>
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        <location>
            <begin position="910"/>
            <end position="960"/>
        </location>
    </feature>
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            <begin position="1086"/>
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    </feature>
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            <begin position="13"/>
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            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
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            <begin position="116"/>
            <end position="126"/>
        </location>
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        <location>
            <begin position="918"/>
            <end position="937"/>
        </location>
    </feature>
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        <location>
            <begin position="1262"/>
            <end position="1292"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS22846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1630" mass="186777" checksum="9B88EE958A920433" modified="2011-10-19" version="1">MTYMQQPSPPPSPDRESQHDDEGAHNLLREDDRQHESLAHEETPPPTLDPSYITSSFPPQPRRTGRGLNPDPKDPSSVPRTPDLVSAPHTPNPNVTTTQESTSIFNPLPERDQESSHTTGSRDSSSNILYSLNSPLTTIPFPSYTLYSDQRPFPRDIWINEFAYDPVLPAWDPTDPNSYVPWPEQDDEDVVRALARIPNTPHKEMINYADTDGNLRYMMLKAPEVFQRAWVQVMRYYDCAMLGKREGLLALVAAHAKIRGLLRDVERLEGEGKNNEEYIEYLQGEWGRMEGMLRRAGALLKRMRQEWRERVSELEEAVVRCGGVEVAMGIVKGLEGESGSEVGTSPVRDPDPDQEEEEEEEXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGELPVREEDVNITARDKVLANRVKKLVEAIDALGIQTTTNRAEIKHLQLTIASLRTQLRKAKLSAQQAVSSATQMTQAQLEQEHAVRIRELEDQLQSVQDELRKTKHELAAVRDQAKTRQEQDAKKIADLRRRYEEAARGRQSNLVRYKRERDQLATQIRDWKRKERELRQRLADMLVVSSHDLDRYQECRRTFLAWVEDMMYATWGEAKQGVPGEFVSFADRNDALLAVQYMQKEASRYAGLQEGLFRKTNEALEKVKGKIELLSSMREQFMEMVLPHLDEFAGLQVTNRYRSHWLYVDRNLQDVVKQLGETLEDVWTRQGEAEQNFRYQKEWVERMHKKLRDHEEFLREKITEAGRMLRELAFPGHHQERVLTKLATDPVYEERDWLWREIVDADDVAIKALEEARRVGREIRQKAPRVGVFQAILRGVEKLEEVVADLRGIDPHTPAEQAIVEFMRKLREKSLEVRDEEPQGQPQAQGQAQGQAQEQPQDQPEKAQDSPQAQEQADPKSADLSPPLLALNALLDQQDVHFSLLLSQERRAIHKFLLHDRHLLQKVENELSALRKLSQRQNALMHEYLLAWESHTSMRLSKGRMQDLYLTVGAFIEEGGLMDERMIWYDKEEVLRRIEGVSGDGGFRRKRAEIRGMIQELRLQVERVKRAMREVEARPQRLESEIAVLEEAALRGRLREGRMKGDLWYSLQRREAKIRRQKQVYWAMLALLGPPHEERVKMWLEEREVEAKRRCEALLTDTLARLQASAPAGHAEGLCFCSLVRAFWPQRFFAAVSMGCCVSNAVPNGPERLLVAPGVAALRKDQGQQQEENPERPQQTQQGQQQGQTQEQGQQEALQAWQGENPDPGHQDLPFHTLPLGGPPRYQPTPLLFGVPPHTCHSYHGHGPILSSSSLATLICHLLTSTLWLILLLLYNPYHMWKTILFLLGAAFIQVPYFLGEIVFLTARHVLACGRAFVFRGFSTSVRMLMLMRRDRRRRRGGGPVPVTLAAALRAQQRLVELGTPPTVASLWAALRNTKEMHLRALRQGRLARFNRFRVPFSRMPTPGGLVLSLLTFFFLFTMLTYLALLSERRIWLQSNDWRGAYLAELARGVYSTGTRVAADGERAVGGWGKDYYAAWSPVSVDYRLVVEPVWAKVEQGAKWVIFGSAHGVARLLGWEGEEFVIKLGRWVKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1N0</accession>
    <name>G0S1N0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0014190</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691932.1">
        <property type="nucleotide sequence ID" value="XM_006691869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1N0"/>
    <dbReference type="STRING" id="759272.G0S1N0"/>
    <dbReference type="GeneID" id="18255457"/>
    <dbReference type="KEGG" id="cthr:CTHT_0014190"/>
    <dbReference type="eggNOG" id="ENOG502SKGN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011750_0_0_1"/>
    <dbReference type="OMA" id="YLPWCLR"/>
    <dbReference type="OrthoDB" id="3057599at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="402"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="447"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="629"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="669"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="755"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="792"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="909" mass="100237" checksum="CA3CB39A60741A37" modified="2011-10-19" version="1">MSAVNSRDRNNNGTLDSHWQHGQHPADPRLVESNLSRQSHEQTDRATSISELLPPPPPSPTPLPLPSPTPPLVSTPSDATPIPSPAAAEPDLPFNRPTGLSFGRPIVIEGPYRRVSDIPPLSANYQPDWVTATPPRDFNMNQDFREELARLDGVITPGIDNTPYIQYAIEALTRGPNTLRDSNSHPPSSSSSSSNPASHYPGAQQPAPAIQHRQPTSEPLPSHPPTSHPPDQPATSPQGQALRPSDDHVHNSGASAQSLAESLLKNGSRPVLPHEWKFVEREDLLNHAHQYQLQASGIPPPLTFRPWPLRTPALLAFMTLCVLMIAALVFSAVYSHKNRGLVTWVAIHGGRYFVFRFLPQLLAGVILLYSQFLVTTMFRILPFVRLASENRDQRDGALFQELYPTTFLWPCLVGPWNVWVAVIVTWLMNFTVPLQSSLFTVILVDDVWTWATVQGVAWTLVALYLALLVSTVIVWRYWASVKQTGLVWDPRSLADIAALVSETNTADDYRGTQLARSREGIRFALRRRASDRLGYWSWKDGRPGVWYTLGNPLDDGNLFPVLNPSGGQRMERQSSEKHTAGASQAAEGLLSGTSKQHHDHDHEDLEAARPIGTQARTRYLPWCLRTNQLLWFTITAFVLVLAVFIVSFLPATRIADGFLPLLRADPKPGAFSAADFLYSFLPALLGMLAFLLFQPLDMHLRILQPWATLSSSANDASNPTSGGGAPASATLLAGYPACLPFETPLRALLNGHWRLAFISFLSPLFLLIPVLAGGSFMALTTRQGQVRMFPNMPGYSLLLAMCVLYVLGLAALFPGRDAMRMPHGVTCLGEIVGYLVGGMDSEHKEEKLMQQPGREDEESPAEFFRGVSSKTELLHRLGVVEGKAGEETRWVFAFGVGGDQLAIWRIKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1Q9</accession>
    <name>G0S1Q9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nascent polypeptide-associated complex subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Alpha-NAC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0014480</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAC-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691961.1">
        <property type="nucleotide sequence ID" value="XM_006691898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1Q9"/>
    <dbReference type="STRING" id="759272.G0S1Q9"/>
    <dbReference type="GeneID" id="18255486"/>
    <dbReference type="KEGG" id="cthr:CTHT_0014480"/>
    <dbReference type="eggNOG" id="KOG2239">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057806_2_0_1"/>
    <dbReference type="OMA" id="SQKMIFA"/>
    <dbReference type="OrthoDB" id="3169036at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005854">
        <property type="term" value="C:nascent polypeptide-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22054">
        <property type="entry name" value="NAC_NACA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14358">
        <property type="entry name" value="UBA_NAC_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.30:FF:000002">
        <property type="entry name" value="Nascent polypeptide-associated complex (NAC), alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000006">
        <property type="entry name" value="Putative nascent polypeptide-associated complex subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016641">
        <property type="entry name" value="EGD2/NACA0like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21713">
        <property type="entry name" value="NASCENT POLYPEPTIDE ASSOCIATED COMPLEX ALPHA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NAC-A/B" evidence="8">
        <location>
            <begin position="53"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="123"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS22969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="202" mass="22401" checksum="07887EF3A8F19A03" modified="2011-10-19" version="1">MAETRVEEVPQQKEEETKKVTVEEQHEDSSSDESEGEAGETSVPAGAPAVIHSRNEKKARKAIEKLHLTRVPGITRVTFRRPKNILFVINNPEVYKSPNSNTYIVFGEAKIEDLNATAQAAAAQQLASQTAEHDHTGHAHDHKHEETKEEEEDDGEEIDATGIEDKDIELVMTQANVSRKKAIKALKENDNDIVNSIMALSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1Y4</accession>
    <name>G0S1Y4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0015290</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS23044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692036.1">
        <property type="nucleotide sequence ID" value="XM_006691973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1Y4"/>
    <dbReference type="STRING" id="759272.G0S1Y4"/>
    <dbReference type="GeneID" id="18255567"/>
    <dbReference type="KEGG" id="cthr:CTHT_0015290"/>
    <dbReference type="eggNOG" id="ENOG502RY7V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014569_0_0_1"/>
    <dbReference type="OMA" id="SKETHAH"/>
    <dbReference type="OrthoDB" id="4495335at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42041">
        <property type="entry name" value="DNA ENDONUCLEASE ACTIVATOR CTP1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42041:SF1">
        <property type="entry name" value="DNA ENDONUCLEASE ACTIVATOR CTP1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="234"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="365"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="449"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="637"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="65"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="390"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="493"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="551"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="642"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="658"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="673"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="701"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="729"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="768" mass="85434" checksum="3D16C7AB820A5779" modified="2011-10-19" version="1">MSTPSSPAGGGSKPLQPVSHNEQRDAAIFSPHRRTDSSVHEKIHQFNTLAMQAKQQERKTFDAALKRAQIGREEAEAEMRRYRDEARMLRKQVEEGKDRERRIAERLEAVMENYAKAKETHAHTQQLWEKEVRRAKKEAFKAQSALLHFQEDAKTARTAQKTAEEAQKAAEEALQTEKERSRSFEQQAEEAQQKVLETEKRLADVQEELAKAQERIRSLEQEVEALRDQLKAQEDTINAMRASTSSKKSRRRSDVDDEPEAPRKRARHSYESDSEVENIQMMWQWEKKRADRAQEQIAFLEAECHLKMCSAAKTLRQRTGHFIVDASDKMILSENTTVFMPKPTPGRSKTDMLRRSTMFSPAKEAREVAPYRTLSQVEAETEARGRESISSKADTSPTASTGSMPVTPKDDDPLFRRSPSMEPSKGAVPPKERTSLLSLLDAPVRQEDPAPLFNIPTIPAPDPNEQPQESESFPLVGIPKIPVLAPRTSTESEPEHESKQVSKPESESKPAPSQHASDHPNGGQQARKPHPRDLSIPARETYPPVPLTDPFPSTANTGLSASTASCSVHDAPYARPHTTAAYYPSASASSAYANPLLKTSAITAHVATTKVPLKEETSDPSLAQRLLKIQRTPVRPTADGAKVWEDPDKKPIFDPTNPALTPTMTREQALQCIRERRDRARSVGREKEEKEKKLAAQPMRKVSGSSVVSNASAASGKASVGSNTSSVGERGRSREREVGARQVSDPTAAAKPAVSKVREVSAIRRVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0S251</accession>
    <name>G0S251_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD40 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0016000</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS23111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692103.1">
        <property type="nucleotide sequence ID" value="XM_006692040.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S251"/>
    <dbReference type="GeneID" id="18255638"/>
    <dbReference type="KEGG" id="cthr:CTHT_0016000"/>
    <dbReference type="eggNOG" id="KOG1408">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005113_0_0_1"/>
    <dbReference type="OMA" id="ASFFTWS"/>
    <dbReference type="OrthoDB" id="6252103at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052779">
        <property type="entry name" value="WDR62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45589">
        <property type="entry name" value="WD REPEAT DOMAIN 62, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45589:SF1">
        <property type="entry name" value="WD REPEAT DOMAIN 62, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="790"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="829"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1018"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1160"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1240"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="870"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="890"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="916"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="927"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="987"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1018"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1034"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1160"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1195"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1255"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1307"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1335"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1378"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1389"/>
            <end position="1407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1407" mass="149084" checksum="A3BA18A919DAB7CB" modified="2011-10-19" version="1">MASTPLNRTKPTTSNSPYSSRSARGHRSRSLPESCCLTLQRVIGSTCCSPTGFDTVNSSFAYIAGGAVVVVDVSENSYSQRFFRARPNAVPLLSSSQASNPSSTQSSTPKSSDSRGRVAPSPRDGTTYQTTDWSESSPTSKTWTSRERIKAATCLALSRDGRFLAVGETGYAPRVLIFSLQEASSDIPLVSISEHTFGVRAVSWSPDGKYLASLGSANDGFLYLWKVDSRTGAMKLFQQNRCTSFVKHMVWMGPSLITLGVRHVKLWRVDDTAENSLSKQKLQGDSTAGSSSAPASFSSASAASASAATSSVSSASSTVVGTAAAAAAAASSSMTAAPPSQPPQKQPLQGRNILLGSMLEATFCCALPISDEKAIICSETGAVCLLEDTGKQPKFAKLLDLSFPISCLSMRGENVYIGGKDGQLACISLESILAGTPEPTIRTSQMVPGFMAMGFLADHLVTIDSKRSIDIWSPDAMLASSQDDSSTTRIPIPGLGDPVVGIQRLAASNSLGASFFTWSSAGRVTVWDMGGLVKATLDIPIEQVEQPVPNGTGGSDPDAANQLVVAKATNDGTLFITGDKLGVLRIVDVAAGECLLETKAHSSDFQDISVLEGESRFLLASCGKDRTVQLFHRSSSPLGEFEHFQTLEFSAKVVQVLIPSEDKVLTCSLDRTLQIYDLVSKEGEPDVIAAIPFKTISLRASPSSMTTSPDNKSIFVSLLDRTVCQFDAANGRLLSSFKCSDEAGHDSVVLESLTYGLIGSYDVPFLLGISNTDKSIRIYEALSGAFLDREWGHTEAINGVVLIDTDETGRKVVSVGEDGTIMVWGLEIQEPTATTSSRQRDPSPEKTPGLTSARPPLRRVLSKAELAEFQRSSANASGASTGRRSPPRGAANTPNTPTASTTNSRRVSRFHVPLSSVRTPNSSEKQASPSATPVPTTTNNMTAQGPAPQPAAATAEDTPSRATRAPSSGRVSPSADAPTPPSESPKAVTSASATGSLRSVYRSRPSLNVLNAITAHTSSTSAPINGNSNASINTAPSRKNSSSSASTTTATAPNSTTNGATTTTTTKSTTRTRATKTTGTNGKTTSSSLSKIPAVKYTYGSLSMATEQTCRQLRAFRKKLSADKSGDVDADLLAQLDSELRLTAAALGERAIRTRVRHGHGHRHHHHGHSHSHGYHGHRGENGNGLGDGVQSDETCDRHGHEHAKAPVSEAMLESLLDQYSERLVSLLESKLVRRLGMWSDNEQSSSSEDSEKEKRKRKEKGKKAHHQQHHHHQGKRRRGLSRKVLAAPEDSMLETETDNRQYGDDSSSSSSGSGSATASASSNPGSADAGDYMSACASGCVSSSSSVGDDEGDETEVGERIDGEFDEGMSTVGWTETEQEPGTETEGEMERSQLRVEEGFKTEAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>G0S262</accession>
    <name>G0S262_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative pathway-specific nitrogen regulator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0016110</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS23122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692114.1">
        <property type="nucleotide sequence ID" value="XM_006692051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S262"/>
    <dbReference type="STRING" id="759272.G0S262"/>
    <dbReference type="GeneID" id="18255649"/>
    <dbReference type="KEGG" id="cthr:CTHT_0016110"/>
    <dbReference type="eggNOG" id="ENOG502RYZ7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007073_0_0_1"/>
    <dbReference type="OMA" id="CTKNGHQ"/>
    <dbReference type="OrthoDB" id="2354469at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47783:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47783">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="108"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="810"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="911"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="937"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="978"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="988"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1009"/>
            <end position="1018"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS23122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1099" mass="122237" checksum="FEE39CE81E424F19" modified="2011-10-19" version="1">MNRIVNTPLGPPPQQKIRFVNNPGQPPAKRRRINAACLTCRKRKTRCDGKKPICTTCSNNGHACMGYSEGEKKEVGVHDDSRTVKIESTPGLHGLDNHSSLLNDTWRRKSTATQNRPPVAGFVDDDMKCDSSSSATVTPRPALDNGNDWDHEEKPASKDTPPNQASSSASSDGSRTANNRSPVHRHTESRRVPYFRYFGTTAIVPGFKKVLVDVIFRKSHQSNNFSKTYSSALGGHDLSSKDLSGYDPDQDPPLDGGERFAYYDAHSPDPVPPLIFMLVDTFFRQLGCNYLFLRKERFVRLLKEKRLEPILVDTVCALAARFVEHPTLIQATTRHFGRPVRKHEYGHLYAQRAKSAIVDHFPCPSVAAVQAALLMAYEAFGANQDSALWMYLGIAIRMVLDLGLQRIEGIKYRGERDPWYTRFWSRRDREELDGPDTKGVEDTLSPEEQREVEQERIDTFWAVFVLDRVISSSTGRPVTFRDDDFDLSLPEPTLDPNTGWPAPFPTFSEIIHLYGRVSDVLNNIRDASDLTEDKMQKLSRMESDLTALYKKQDSRLHFNPVNFRQYVEMNQGTTFILLHFWFHALIIVLHQPTLLTPFHDMKPIQLLPNSPQLSMSSAKTIADILAFAELIDPKSLVGNPFTSQPIYIAACAFLMESVANTSTPPSREGTPVPDAKNDHNRWGREGQPKHSLLAHAANENYQRCYKSLQELEKYWAGVGYILNALDQKSKGIWDCEAFSKDESTYAERELRSRLDVSNSPAPPTAPFACALLTGTTNSPNTNVTVMLKDSATAQVATATITLPPPSVLAQSAQVPAPTPPGNMVYDPIRQSLPGTPQPPTYLQPSIGTPRFPPNTPRESRSSQSPGSGKLHVQIKYEMSPPVDMDSINQRGDMRPPPLHAASGSFSDHDSMPQSSYNTPNSQQHSAYDSATMHDRSSSGTPTDSGVSQQHSLPAHNHNSSYLSHHHDQYGHNHHGNSNHHDYMHHDNNSASHNTNYVTGMDFSQSNMIPGSGVSPSPSNGGGSTGFGMLNPVPEINLNDVFELSTDINIESLGTESDTMVAPAPWLELLPLERLVGLFEEGINAQQGQTQGQWYHHGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2A7</accession>
    <name>G0S2A7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mitogen-activated protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0016570</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="2"/>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692159.1">
        <property type="nucleotide sequence ID" value="XM_006692096.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S2A7"/>
    <dbReference type="GeneID" id="18255695"/>
    <dbReference type="KEGG" id="cthr:CTHT_0016570"/>
    <dbReference type="eggNOG" id="KOG0198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000961_3_0_1"/>
    <dbReference type="OMA" id="MQISPKP"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000196">
        <property type="term" value="P:cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000182">
        <property type="entry name" value="MAP kinase kinase kinase mkh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000387">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF48">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE BCK1_SLK1_SSP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="1335"/>
            <end position="1604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="306"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="629"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="708"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="840"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="914"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1184"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="329"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="364"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="407"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="437"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="460"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="636"/>
            <end position="646"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="658"/>
            <end position="675"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="732"/>
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    </feature>
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        <location>
            <begin position="763"/>
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        <location>
            <begin position="801"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
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        <location>
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        <location>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1099"/>
            <end position="1115"/>
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        <location>
            <begin position="1190"/>
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        <location>
            <begin position="1207"/>
            <end position="1222"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1250"/>
            <end position="1263"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1264"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="1364"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS22140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1685" mass="183213" checksum="F8A0FE3C20EB03CC" modified="2011-10-19" version="1">MYPQRDGTRPFQVPPPPPPMSPPPSHGINNLMTIPPPPPRYPPQGTSSSTIPPPPPGPPPNTAYPNSALGTAAPWTGAGWPSFNRGPLFPPPPPANATAPIPTYDPRLHPHHIANPNPTSGPTTLTVPPPPPPPPPPQPEPDVPGVSATYIPTAGTTYGVGVGIPGFGIDDSDWLGSATNTPSHETSNREQLFAAALAQKGATSNTVTTISSVPPEIAAQWPLEKVIAWLQANNFSREWQETFKALNLYGAPFLELGSSHGGRGNFGMMHQQVYPELARQCRERGTPWNQTKEREEGKRMRRLIRSIVTGRPVDPAKVAPSSGSHTRSDSTATSVTASAATEASESPSSTRPPASGLHIRRVSQSRTMPPTIGNSTISSDQNHRNLMRNIDAEIPRRHSPNPGDPRNSPSGSPIPQFATTTGNIAASPHSGGRWTHRSQPSTDSVSSNHAQYGSGVPPDAAEKLRKDLIEPPRISEGNRRIGFDGGRPSPQDHGDKSAGSDPPGSAKGSGWFPHFFKKRREGEDSPTSPKWPHFDRPTSKRGHHGKVYILATLDCRIFRMIDITDTETATDLRQLICWNLNVEESAQIYLTELGKFEHEGDPLDDNKLISAKHQKGDAAGTLKVFVRPVVSPPPRGNGVPVSSSSGQLTVPVDEDAYGRLSGRQRSSSSPPTSRQNTLMGRDRDDKSLSQEAIQYRTEQLRKQQEYLAKKAAAKEGNSPSTETPIGIVGRNVDFDQPRLSPYDDRKVDSLFPQRKAPAPPNEPSATSLKANSLSKNQGSPGHTSRPSLDGRHQKRPSGSSDMREEVMAERPKRWAGPPDGGIVGGLLVNMAGRMAVPGMGQTATVPNSQRALSPHRAASMPTTSTETHEKGKAASSNVVDNGQQAHSGYGPVGGGAGRWLGYMPDMPGSTTWGTNPNAPFLVPDYSPGGTPQLSYGRDDHGSGARPSDRPPYGTEAKRSQTARAPSCADFSPASTRAPTSDSIPATSSGEQTFSQVDDEFPQDNEIRFSRTSTLVDKEPAQNDSDEDSDDGLFAKPIANRSKPKAQTQTEDDDDSGLINKRPSLRVNTKRAGKTFSVSFTSPHVSAEGKTPAGDDEESSSAWSQRRTPGTPGSESWDSEERERLNRRKSFVEKDVWANRPPTDALINNLEDFFPNVDVDQPVIEEGDGEFIPPIDEMDEIRAEQSNAPPAMSPPIPPLPANNAASSGYNESDTLGSDESTLKASDARPLSIQTVASRSVRKSGGLGRMKSIREVARGAHEASKRYTQSQQALANQAPGNPSRNTTLLRRKSTKMFNANIVQIRPERGFQALQQHNAVPQQTNNNTGLKRQTTFRWFKGQLIGKGTFGRVYLGMNATTGEFLAVKEVEVNPKAAGGDKKKMQELVAALDQEIDTMQHLDHINIVQYLGCERKETSISIFLEYIPGGSIGSCLRKHGKFEEPLVASLTRQTLSGLAYLHREGILHRDLKADNILLDLDGTCKISDFGISKKTDNIYGNDKTNSMQGSVFWMAPEVVRSHGEGYSAKVDIWSLGCVVLEMFAGRRPWSKDEAVGAIYKIANGETPPIPEDIQGTISPAALGFMLDCFTVNPTERPTADRLLSQHPFCELDPNWSFYDTDLYKKINGIWYHQHHNMTSQPEFYHMPFHLSELPVVPAIEPELEDGRWWFDVLSLNGSRRQGSHPESYSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2E1</accession>
    <name>G0S2E1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Superkiller protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0016910</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692193.1">
        <property type="nucleotide sequence ID" value="XM_006692130.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S2E1"/>
    <dbReference type="GeneID" id="18255729"/>
    <dbReference type="KEGG" id="cthr:CTHT_0016910"/>
    <dbReference type="eggNOG" id="KOG1127">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001688_2_0_1"/>
    <dbReference type="OMA" id="CQWELDP"/>
    <dbReference type="OrthoDB" id="421075at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039226">
        <property type="entry name" value="Ski3/TTC37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040962">
        <property type="entry name" value="TPR_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704">
        <property type="entry name" value="SUPERKILLER 3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704:SF7">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18833">
        <property type="entry name" value="TPR_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="460"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="655"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="970"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="321"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1104"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="336"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS22174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1433" mass="157927" checksum="10B1B6B5BBF14583" modified="2011-10-19" version="1">MSSVKALLRAINDAIKQQKWDAAIEAAEDVFQKDPKNYQAHIFLAFALDKKNKLDEAEKTYLAAAALKPGDSQAWQGLIKLYQRQKNKKLKEYQRTAVRLAEIYHDANELYKCRDVIDKFVDHARTQGDRLQYVDALDVILPGSPIYSVLEGSVPAPGKTYELQAQIVEAEEKKRINTLIGERRTRIGARVAEVTIETKREVYSQSRLLEIYQNVINWATDDDVRRTYEEKQLQYCYDRMLAWPPGEQKDQEAATVRRLANDMVIIRHPFKFAWDIAINWQDNKEVKQWDPAVLRQYCTFFPDSDLSRVIMGYLTSEISPFPKESAQPTQQTALAESDEDESEDDEEGGGVPTTYVPLTEEDRLAMFMEGSSSADSLFALRLTAEYYLHIEEHEMNVELMRKAVEHLKLERSRTGFRFQHTEDAFSLALGTSLVFYQSPRHHQEAKALFDKVLSHDPSSTPALIGVGLIYEEEEEYTEAIGFLERALQRDPSNLRVRTEAAWVKALNGDFATAKAELQACLPQLEKAKNQKELLAQTQYRVGHCIWNLDTSKAARKSRTGAYAYFLEALKNNLNYAPAYTALGIYYADYAKDKKRARRCFQKAVELSPSEVYSAERLARSFADDGDWDRVELVAQRVVDSGKVKPPPGSKRKGISWPFAALGVAELNKQDYRKAIVSFQAALRIAPEDYHSWVGLGEAYHGSGRYIAATKAILNAQRLEETARDKIQGETWFSRFILADIKRDLGEFDEAIALYKAVADEHPDEQGVVIALMQAMVESAMDSLDKGFFGKAVDLAKETLKVASQACRAIQETFNFWKAVGDACSIFSSVRGRLSEFPLDIVQQILSDEDLAPSNGVPGDQTDSSLLYTVLQATITSHTRAIQASAHDVHAQAVAHYNLGWAEFRAHTCLPSQKKASPHLKTAIACFKRAIELEAGNAEFWNALGVVTSTVNPAVAQHAFVRSLHINEAGAHVWTNLGALALLQGDVQLANEAFTKAQSADPDYAHAWLGQGLVALLVGDVKEARGLFTHAASIAEASSRPVRRHYAVAMFDMLLAARGAALPITALLQPLLALSQLAALEPGELGFSHLLGLMQERNGEPRRAVETLEGVCGRLEERYERTEAATDLKHFAIAKADLARARLAAGEYEAAVEDAEMALQLSEEGSELTAEERARVRLSAHVTTGVAKYFLQSPAEAVTALDAALDESNSDPDVACLLAQILWAEGSEASRERARDVLFGVVEATSPPHVRAVVLLGVIALLDGDEEGLEAVVSELQGLRGAGTSDGDGQGQGKGLSVTEMEDIGIVLRAVAGLGSLTTETSTEVVTAQDQKASQARQDVMYHPWLPHGWSGLAASARASATDDEGEELGRSAAEMALRVAVKGVPPRGELEAEDLAKAYAGTGRVRDAQVAVWIAPWCGEGWASLRGGVAGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2T8</accession>
    <name>G0S2T8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0018450</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692340.1">
        <property type="nucleotide sequence ID" value="XM_006692277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2T8"/>
    <dbReference type="GeneID" id="18255883"/>
    <dbReference type="KEGG" id="cthr:CTHT_0018450"/>
    <dbReference type="HOGENOM" id="CLU_1758593_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="148" mass="16752" checksum="B1E0C6EB32086DCF" modified="2011-10-19" version="1">MLSTGNSEEFRKELSGISGKAEKKFKPLTEEEEIKWVQVGAIPEFVLRGIVPEEHGVQSAPAKACHRKLVAGWPERGFQPQGSQKFEHEWVSSRSAIAAEECEERWEHPNHAKSSDDVIAQAGKQQGCGRRWRVSFVQQQHAEREMMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0S375</accession>
    <name>G0S375_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0019960</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692477.1">
        <property type="nucleotide sequence ID" value="XM_006692414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S375"/>
    <dbReference type="STRING" id="759272.G0S375"/>
    <dbReference type="GeneID" id="18256034"/>
    <dbReference type="KEGG" id="cthr:CTHT_0019960"/>
    <dbReference type="eggNOG" id="KOG4169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_8_6_1"/>
    <dbReference type="OMA" id="PVPHFDY"/>
    <dbReference type="OrthoDB" id="300709at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF28">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="2"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS22458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="327" mass="35461" checksum="9DE7DE45FFE0B02D" modified="2011-10-19" version="1">MAKIITILGATGAQGQGVVASFINDPSYKVRTITRNPSGAPAQALAAKGAEVVQGDFNDLASLKTAFAGSHIIFAVTNFFEPFAKLFDGPKTAEIEKQQGINIAQAAAVTDSLEHFIWSTLPNSHAVSGGKFSVPHFDGKASVDDYIREKEPALLAKTTFLWVTWYHTNYSFPVYTPFKVPTAFADVHVQLGSWSPETPISTIGDVRLNLGKFVRAAVEQPEKAANGAYVLAAVETISVEGLLKLWGETHGKKTKYVKIDPEAFRELWPVLAEELGVMMDYWDATREKSWSDVSGGKVLTKEDLGIQGLQTLEEGLKDLAAKTATAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3G4</accession>
    <name>G0S3G4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Diphosphomevalonate decarboxylase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0020920</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RUS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692566.1">
        <property type="nucleotide sequence ID" value="XM_006692503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3G4"/>
    <dbReference type="GeneID" id="18256130"/>
    <dbReference type="KEGG" id="cthr:CTHT_0020920"/>
    <dbReference type="eggNOG" id="KOG4249">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015325_5_1_1"/>
    <dbReference type="OMA" id="TAIEPEC"/>
    <dbReference type="OrthoDB" id="364779at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006968">
        <property type="entry name" value="RUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054549">
        <property type="entry name" value="UVB_sens_RUS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770:SF31">
        <property type="entry name" value="RUS FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770">
        <property type="entry name" value="RUS1 FAMILY PROTEIN C16ORF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04884">
        <property type="entry name" value="UVB_sens_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein root UVB sensitive/RUS" evidence="6">
        <location>
            <begin position="35"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS22547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="425" mass="47241" checksum="564C2C1A5CA780B0" modified="2011-10-19" version="1">MSRRFYDIDAAGEVLCTYTEHGAREQLQTEKTKVPLGKAILYAFLPAGFPHTVTEDYLSYQLYDSLQAFASSITSLLANRAVLEGLGVGDSSSSPTGALILKITGDTISRIATILFAHRMGRAIEPECKFYRFLADIFNDSAQFLDLLTPALPYFPKLSVIVSAGVLRSLCGVAANASKASLSAHFALTGNLAELNAKEASQETVVSLLGMLAGSLVVRLVEDKQVVWFLMILLAGVHLTMNYRAVRSVKMRSLNRQRATIVFREWLDHGTVLTPDQVAKRESILCKSRGNLASKSGDYHGFCDFGTYGELVSWNPRGYHRYDFETSTYFMAIWHRGGTFYMKIALKEGVKTPLAAWFDAVNHAYHFDSALKDGLQSHFENEMPLGYVSDEQKEQLFAALAAVDWDLETNALETRLPVRVRSYIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3H3</accession>
    <name>G0S3H3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0021040</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
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    </dbReference>
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        <property type="entry name" value="2EXR"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1"/>
            <end position="78"/>
        </location>
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            <begin position="395"/>
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        </location>
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        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
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            <begin position="42"/>
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        </location>
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            <end position="61"/>
        </location>
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            <begin position="437"/>
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        </location>
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        </location>
    </feature>
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        </location>
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        <location>
            <begin position="597"/>
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            <begin position="649"/>
            <end position="661"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="661" mass="74861" checksum="685A1B1070FCD928" modified="2011-10-19" version="1">MSEESEESDNIGYLAQDLSGSEDEESISESELDQETEEESSSSDAQQLLDLEAFESGDSDLNESHSDYHGSSGISSAKTTSSFPQFIRLPLELRYRVWEFFCPDLTAKARVYWLQYSTPSPYQPPIRPPKSHPVYDGPLLDAQTRPARTMMAVHRESRQLALKALPDVLRFQPKGKAWLRFNARRDIIYLSNAEDFFAYEEIPRIPGFTDQIRHLAVEVRVLAELGNLHTILLWATFPNLEAMYFATEPVNHSPEYLRWCTSKSSNQYLVEINPDQDPWLEEPDMLYCWPDIKNHRDFAKKEINKKKLMEDMVQKADIDITWASSRTLNLWPLVQFQRDSNLDWFDQLATWDGKGKIEWPSDSDAFLYDSVLDEYESSGIDDSELSDLLDGLSSSEELDDFDEENSRISTSTDDETSEDGVTSATDLPSDDGANFAEFSNTESSSATNRGSPSEAESDHPVPQQYRSRLKRPRSRVVDSESEESESDGPRKCARFSGRNRRVIVDSDDGEAESSHDTLTRALRKRTVMSEDEGEEDDEQRDEDHDDNISQSSAASDRPDASLDGDDSDQDWGAAVEKPLSFTEKLQLHCEKVPIPPGDDDDGDSGDNDSSDKEGVSGDDYDAYTYADFQDDEDGNETLDHDSHGQDGYFDNEDEEGYGYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3H7</accession>
    <name>G0S3H7_CHATD</name>
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        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0021080</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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    <dbReference type="STRING" id="759272.G0S3H7"/>
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    <dbReference type="OrthoDB" id="3524154at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0000981">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057026">
        <property type="entry name" value="Znf-C2H2_ascomycetes"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_sf"/>
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    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
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        <property type="entry name" value="AZ2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF24537">
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    </dbReference>
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        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
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    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
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    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
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            <begin position="457"/>
            <end position="485"/>
        </location>
    </feature>
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            <end position="22"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="263"/>
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        </location>
    </feature>
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        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
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            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS22560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="600" mass="67024" checksum="1912140EDB80BE09" modified="2011-10-19" version="1">MAIRGAVQHEVPPPLPPPRYVPPDCPVCPSLQGKERMRREEYGASDTDSFGLSFRRPDFSLRNEPPDDGYHSLDSTRSSSAFLPRFGHHAMKSLRPGMDTRDSIDSSMLEKLNRSVGRSGLSTSLSDLSHTRHIQPPPITLSLPHRTKQPYLESIFTNSSGGLSATSPLGAPFGRSSSFAEGTDYDRAPYRNFSRIHGGSVSEDRNGCAYTGTDVRDDDVHFPMDDSETTRMRSLHIDDLWASRGGERERDWDRDKDWERDHRDREYYQPGQKRRASSPPGDEAGLGSDPLRRRDGALARSSPTPRLLMPHSSAPSICSVSRSGSHTNYLPTTSNLTGMGSFGRRSPSVISPGGLSPTDQLNCSNNYPTPTTLSAAPHALTGRTSTASSPHQRTHSEQPLLAGRTPVSPRKLPEIPKSSSTLSAKLKGPYMCECCPKKPKKFDTEEELRAHEAEKQYECSFCGNRFKNKNEAERHQNSLHVRRHSWSCAALTSYERAFHESTTRPGEVDICGYCGKEFNRTGGSQGAQGGLRASEQDWEERVRHLQEIHKFRECNASKKFYRADHFRQHLKHSHAGTSGKWTNMLENACMMEEEPSVQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4C3</accession>
    <name>G0S4C3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcium channel-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0039670</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS22081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006694314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4C3"/>
    <dbReference type="STRING" id="759272.G0S4C3"/>
    <dbReference type="GeneID" id="18258005"/>
    <dbReference type="KEGG" id="cthr:CTHT_0039670"/>
    <dbReference type="eggNOG" id="ENOG502QT9R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009570_2_0_1"/>
    <dbReference type="OMA" id="HMERPAN"/>
    <dbReference type="OrthoDB" id="2373987at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056337">
        <property type="entry name" value="LHD_YVC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF1">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23190">
        <property type="entry name" value="LHD_TRPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="502"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="562"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="588"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="YVC1 N-terminal linker helical" evidence="3">
        <location>
            <begin position="72"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="4">
        <location>
            <begin position="293"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="668"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS22081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="700" mass="78899" checksum="87802BC23B7BE750" modified="2011-10-19" version="1">MGADFSDSSSRSSFEADDDPEAVLRPIGDSDDDDNLAPRYRLRRLAPARDDAGSSSASPGPGGVNLMSVYVTMHRIRRLIMAAIDDTYTLDELRAPQMDHQVVRPLVERLYNPEDMALVYCLIANRVQFLRPRSASSQHQGVNETRAMLCEILATRILRRFHEDHTGRTGLLLLANILVSGFDPCDTAPETVRALRPQWAVQDRGGHERKLTALELAIVSESKMFVGSPACQLVVDAVYKGVVVYTPVSFVDFLPDHYKHHPVSLYEPRRAAILNHHRLIVPQIRNIIELMHFAILLVLYMLTVVHFGLGHDLDGLRFFETVFNIFAAGWVLEQFAAIVEHGWEVHAQNLWSFLDVTFIVIYAAYGVVRTFELLLTDHDYYALPVLCTAAPVMLTRIAFTLMPNNIVFIALHAMMRDFTRLTFIAIWCFAGFVVGLLFLARTSGDNSLNVGVTWATISKWLLWYVPFVYLLLITADELRIWFGLDGTGIERAADFHLILGPTLIITFAFLGNTLFLTILVAILTNTFSKIISNEAAEVQFRRAVLTFQGVKSDAIFSYPPPFNILAMLIMLPLKFMLGPLAFHRANVAVIRTINAPILLIIALWERRHVLARKSKPFRIKSWWYWPRLSPHNDIQAVFGSEPPPEVIDALEKMDSLNEVIGVAKDAHMQRPQSARDFSGPPSAVRRRMTAGSGSIRRLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4T7</accession>
    <name>G0S4T7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0023480</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692812.1">
        <property type="nucleotide sequence ID" value="XM_006692749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4T7"/>
    <dbReference type="STRING" id="759272.G0S4T7"/>
    <dbReference type="GeneID" id="18256386"/>
    <dbReference type="KEGG" id="cthr:CTHT_0023480"/>
    <dbReference type="eggNOG" id="KOG0061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_57_7_1"/>
    <dbReference type="OMA" id="MCVNGFM"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001305">
        <property type="entry name" value="ABCG transporter ABC superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052215">
        <property type="entry name" value="Plant_ABCG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48042">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48042:SF11">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="51"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="535"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS20516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="561" mass="62262" checksum="B536D57A179C1E81" modified="2011-10-19" version="1">MVPEVQYSSGSSHNDKEPTALNSAAFDVEQQAVAEAHLRNTTIKSIAWKGVKVTVKDRKTKLPKSIVDDVEGVVEAGELFAIMGPSGCGKTTLLNFLASRPTGPSSSTSGKILVNGNPMDSRSLTLFHRTTSRFVEQEDTMIGSLTVRETLHFASRLATASSSSERISRVEGLLDAFGLREQANTLVGTPLRKGISGGQKRRLGVASQLITGPKVLFLDEPTSGLDSVAGWEVVKYLRGVTKRNNLIVIASIHQPSTATFNLFDKLLLMSHGKMHYFGPVAAVTSHYKSLGHQVPVHVNPAEFLLELVNTDFTTDKDTASRQLEDMHLAWMNSVKSTELRVLLDSIEKAGSNAVIDLGTPEKKPTHIRLVLTLLHRSFLKSYRDVVVYGIRLMMYMGLAIMMGTVWLRLDTSQESIIPIINALFYGSAFLSFMACAYSPAYIEDYMQYIKEKRNGLYGATSMIVSNFLIGTPYLLSVGGFMVPPTILNVFYKYVFHYWDYQKYAFENMLINEFSERVYVCQKTATDCQFHVQDDKGVGHPRPANAKKGTYLKAHQKSRENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4Y5</accession>
    <name>G0S4Y5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TRIP4/RQT4 C2HC5-type zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0032110</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693652.1">
        <property type="nucleotide sequence ID" value="XM_006693589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4Y5"/>
    <dbReference type="STRING" id="759272.G0S4Y5"/>
    <dbReference type="GeneID" id="18257249"/>
    <dbReference type="KEGG" id="cthr:CTHT_0032110"/>
    <dbReference type="eggNOG" id="KOG2845">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027500_1_0_1"/>
    <dbReference type="OMA" id="MWASPQE"/>
    <dbReference type="OrthoDB" id="338816at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180022">
        <property type="term" value="C:RQC-trigger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039128">
        <property type="entry name" value="TRIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009349">
        <property type="entry name" value="TRIP4/RQT4_C2HC5_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963">
        <property type="entry name" value="THYROID RECEPTOR INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06221">
        <property type="entry name" value="zf-C2HC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRIP4/RQT4 C2HC5-type zinc finger" evidence="2">
        <location>
            <begin position="259"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS21356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="556" mass="60308" checksum="5495C9A39099AA9F" modified="2011-10-19" version="1">MSKEQLFQILSLPDDALQQVLDYASTLSKGEAAQYFTDMLGDSPQVIEFISTFNSRRSDPKLLSKPPSSVPGATPSSSHNFEVESVPKHRSRQKKQKPSLHTPPPRQVASFEVAAGTVYNKKDLQQDYIPPARSGASTPSISDASYGKKLSISSTKIAPPPPPTQQSKPPPLFVAGTLVSELGLPKQKSRSNPSSRTATPGPSSSRNNNAKIAKVSITGGVPMHGQSTALADFDEAIRALEISTNPTHFSNTAKGIAARRCNCVATRHPLLEAAPNCLNCGKVICIKEGLGPCTFCGQPLLNPAEVQSMIKELRQERGREKMAADREAHKKTGTGGGQSQRSYANPLKEVGLAGPEDLSVAEAMARQHRDKLLAFQAQNAKRTTVKDEAADFDPSLAGSMWATPEERAMALKRQQKLMREMEWNAKPEYEKRQQIISIDITGKKVFKQTVNMERPPSPDNHVDTEDVKSRAVVTIEDGGQGHGGAYSKNPLLGGLIRPIYEPKGKQAELPGKRARGTRWRRVQDDLDDNEAVILDGGIRGEKAEVITTTGDEPACG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0S527</accession>
    <name>G0S527_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcription initiation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0023850</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692848.1">
        <property type="nucleotide sequence ID" value="XM_006692785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S527"/>
    <dbReference type="STRING" id="759272.G0S527"/>
    <dbReference type="GeneID" id="18256423"/>
    <dbReference type="KEGG" id="cthr:CTHT_0023850"/>
    <dbReference type="eggNOG" id="ENOG502RYP8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042838_1_1_1"/>
    <dbReference type="OMA" id="ICAHAAP"/>
    <dbReference type="OrthoDB" id="414418at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051710">
        <property type="entry name" value="Phosphatase_SH3-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469:SF51">
        <property type="entry name" value="TRANSCRIPTION FACTOR TAU 55 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="277" mass="30674" checksum="54748EB1FED3D91B" modified="2011-10-19" version="1">MPLEVIYVTRHGFRSNWLVDPANGNYSNYLRSPTGLPADPELTAHGVDQAKELAVRLMEVDPPIERVYSSLYYRCLQTIEPFVRKAQAASPDKPLKVRGETGLGEWYGSADFEHPVPASLDKLEPLFPDLLDMSYVSAVTPNRMGEEINELHDRVAVAVKEVIAQCDRDGIRSVLLCTHAAVVIALGRVLTGLMPDDFDEEDFRCFTCGLSRYRRRSAPITESRGTGSEQQDKAVDSADHESCSRVPDWRGAGEERGCLTSASDSQGQKDSDSRGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0S533</accession>
    <name>G0S533_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxidoreductase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0023920</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692854.1">
        <property type="nucleotide sequence ID" value="XM_006692791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S533"/>
    <dbReference type="STRING" id="759272.G0S533"/>
    <dbReference type="GeneID" id="18256430"/>
    <dbReference type="KEGG" id="cthr:CTHT_0023920"/>
    <dbReference type="eggNOG" id="KOG1205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_48_0_1"/>
    <dbReference type="OMA" id="IDVIANC"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="319"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="334"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="383"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS20558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="48547" checksum="EF014FF78616A276" modified="2011-10-19" version="1">MDTRSVPDTASVAGSDVASSKTRLQLPPSCGPPEPGQPTKQMVWIVFGGTGHMGRSLVKSALSHGDLVTTVGRVFETSPEDMAKVNSDTCLGLLCDVRDGASVRRVIERTIARFGRVDCIANCSGYGVIGACEDQDEHELRNQFETNFMGTLHIVQASLPYFRQQNGGRYLIFSSTSGALGVPGLGPYCATKYAVEGFVEAMLYEVDSFNIKATLVEPGLVRRDEPADPKASPLPTWGHFLIKPASEAYSHATSPALHAQRMVQWLGDRQPTSAVKCAELVWQLAHCSYPPLRLLLGSYAIESIRDRLRSVTEELEDWKHLNFPPPPDAPGAEELLKKDDNRDNKAPESQQDKDKEENEKKEEVEQEAGDGGDDAMEKEDDEEKNREKGKDSKKDKPETDEMDVDKEQGKEMEKENKDKDEVMQDAPPEQPSQEVKPND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G0S562</accession>
    <name>G0S562_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA helicase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0032380</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693677.1">
        <property type="nucleotide sequence ID" value="XM_006693614.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S562"/>
    <dbReference type="GeneID" id="18257276"/>
    <dbReference type="KEGG" id="cthr:CTHT_0032380"/>
    <dbReference type="eggNOG" id="KOG0952">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000335_2_0_1"/>
    <dbReference type="OMA" id="MCSATEF"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18020">
        <property type="entry name" value="DEXHc_ASCC3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18022">
        <property type="entry name" value="DEXHc_ASCC3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000198">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000002">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000231">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000004">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000102">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF13">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="303"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="527"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="1165"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="1373"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="22"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS21381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="2011" mass="226413" checksum="E4E843918ED44E86" modified="2011-10-19" version="1">MAGSLNGCTSLAEWRAQAEAMKTAVASLSPTQPLPGGDSDWSDDDDIDRAYDPRSGPRDVWDFISDDELDEIGFDSGDLYDGVDGEDHGYGSSSSSKYDMSWLSARCAEIASKRSGLSAGELRDQIVEILSVARPQGELQSLLTDLVGFDDLEFVVDLVSHRAELVAAIASDRIHGDEEMRAGVEGPRLLTKAQRQAELKRRDWEHKHAPLMAAREKEEDLPHVYRRYAAGNTLSHTGKGYALPAGSQRLEFDKYEEYVVPAGKPGSLWPGQKLVRIADLDGLCRNTFKGYKTLNRMQSLVYPVAYKTSENMLICAPTGAGKTDAAMLTILQTIGQYLTPSPAEDPAVTEFDVALEDFKIVYVAPMKALAAEITEKLGRRLAWLGIRCREYTGDMHLTKSEIVQTQIIVTTPEKWDVVTRKGTGDTELVQKVRLLIIDEVHMLHDERGAVLESLVARTQRQVESTQSLIRIVGLSATLPNYIDVAEFLGVNKRAGLFYFDASFRPVPLEQHFIGVKGKPNTKQSRDNLDQVAFEKVREMLERGHQVMVFVHSRRDTQTTAKMLLEKAADNACLDLLDPSGHERYELAMRDVRQTRARELRELVPKGIGVHHAGMARADRNLMERLFGEGVLKVLCCTATLAWGVNLPAAAVVIKGTQVYSAQDGKFVDLGILDVLQIFGRAGRPQFEDVGIGIICTTHDKLAHYLTAVTDQLPIESRFASRLVDNLNAEIALGTVTSIDDAVKWIGYSYLYVRMRRNPMAYGIDWTEYDQDRQLVGRRRKLAIEAARKLQQCQMIVFNERTEELRSKNIGRIASQFYIQHTSIELFNREMRQDADERDILRMIAKSGEFDNIQSRNNEANELIRMRNDEDMIPYEVPEGIDTPQAKTNILLQAYISRAQPDDFALVNDLNYVAQQAGRICRALFMLALNHRWGYQCLVLLTLAKSIEKRIWMFRHPLHQFDLPKPVLNNLDMKEALSIESMREMEASEIGNLVNNFRMGGKIRKLLDHFPTLSVEAEVAPLNRNILRVKLSITPDFRWNDQMHGTSEGYYIWVENSDTSRIYHHEFLVLTRRKLHDTHELHFTIPMEDPLPNQIYVRAVSDRWLGAETVTAVSFQHLIRPDTESVYTDLLNLQPLPITALKNPALEELYAKRFRFFNPMQTQLFHTLYHRDVNVLLGSPTGSGKTVAAELAMWWAFRERPGSKVVYIAPMKALVRERVKDWGDRLAKPLGLRLVELTGDNTPDTKTIRDADIIITTPEKWDGISRSWQTRDYVRKVSLVIIDEIHLLAGDRGPILEIIVSRMNYIGASTGRPVRLLGMSTACANATDLASWLGVKEGEGLFNFRHSVRPVPLELYIDGFPETRGFCPLMQSMNRPTFLAILNHSPEKPVIVFVPSRRQTRLTAKDLINLCGMEDNPRRFLHMSEEDLQVNLARVKDDALREALNFGIGLHHAGLVETDRQIAEELFLHGKIQILIATSTLAWGVNLPAHLVIVKGTQYYDAKTEAYRDMDLTDVLQMLGRAGRPQFDDSGVARIFTQEAKKDFYKHFLHTGFPVESSLHTVLDDHLCAEISAETILTKQDALDYLTWTFFFRRLHKNPSYYGLEISAEEHNTLEAQHRANEYLVSLIENSLDELETSKCVEVHPNGDLDATPLGRIMSYYYLSHRTIRHLVRRADAIPQASLLDALAWMSRAAEYDELPVRHNEDLINAELAKALPFPPSAVGGLPMWDPHVKAFLLMQAHFSRVELPITDYVGDLTSVLDQSIRVIQASIDVMAELGRLTSALRFVTLLQCVKQGVWPDDPAVAVLPGVEEPVPEAAKKLTIKELASLPREDHPSLAKILSISPHQTNRFNKALSALPDVEVSLPSDSLTPESITVVLRRKNPLTDREARAYAPRFPKSQTEGWIVIVGDKQRDQVWGVKRVAWQGDVGVGRRPSAKAVVKIPSPDVVLDDEVGKKQDGEAEGRKVDVWVLSDAYVGLEWVFDGVVLPAPKKEMRIDATGVVDKAGTGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5C2</accession>
    <name>G0S5C2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0024290</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMP-30/CGR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692891.1">
        <property type="nucleotide sequence ID" value="XM_006692828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5C2"/>
    <dbReference type="STRING" id="759272.G0S5C2"/>
    <dbReference type="GeneID" id="18256467"/>
    <dbReference type="KEGG" id="cthr:CTHT_0024290"/>
    <dbReference type="eggNOG" id="KOG4499">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036110_3_0_1"/>
    <dbReference type="OMA" id="WAGTMRY"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004341">
        <property type="term" value="F:gluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907:SF47">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="4">
        <location>
            <begin position="23"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS20595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="304" mass="33596" checksum="71D6BEFAE7C2A9B9" modified="2011-10-19" version="1">MASTEGIQQWQVSEPWLNIRCGLGEGPYYESASNTLRFVDIKKKQLHTVSLTEGPASHKVVEFDERITVTADIEGRDPRDAIVVGAKQGLAVLDRKTNKYEYVIKFPEVAEGRIRSNDGGVDPHGRFWMGTMTDFGCNLGPEGSLYCFDGNNTPAPTKVKGDLTIPNTIGWSPDGRTMYFTHSSARTIFAWDYDVATGELSNERVFYTHDGPGEPDGFRIDTEGNLWHAVYGESRVLKISPEGKIVGEVKIPARNATCAELVDGVLYVTTAGDDEGSEEERRYAGAVFRVEVGAQPTPRHLFKL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-08-03" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5Q0</accession>
    <name>ODPX_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pyruvate dehydrogenase complex protein X component, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">E3-binding protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Pyruvate dehydrogenase complex component E3BP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">CTHT_0025050</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2021" name="Cell Rep." volume="34" first="108727" last="108727">
            <title>Integrative structure of a 10-megadalton eukaryotic pyruvate dehydrogenase complex from native cell extracts.</title>
            <authorList>
                <person name="Kyrilis F.L."/>
                <person name="Semchonok D.A."/>
                <person name="Skalidis I."/>
                <person name="Tueting C."/>
                <person name="Hamdi F."/>
                <person name="Kastritis P.L."/>
            </authorList>
            <dbReference type="PubMed" id="33567276"/>
            <dbReference type="DOI" id="10.1016/j.celrep.2021.108727"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2021" name="Nat. Commun." volume="12" first="6933" last="6933">
            <title>Cryo-EM snapshots of a native lysate provide structural insights into a metabolon-embedded transacetylase reaction.</title>
            <authorList>
                <person name="Tuting C."/>
                <person name="Kyrilis F.L."/>
                <person name="Muller J."/>
                <person name="Sorokina M."/>
                <person name="Skalidis I."/>
                <person name="Hamdi F."/>
                <person name="Sadian Y."/>
                <person name="Kastritis P.L."/>
            </authorList>
            <dbReference type="PubMed" id="34836937"/>
            <dbReference type="DOI" id="10.1038/s41467-021-27287-4"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBUNIT</scope>
        <scope>DOMAIN</scope>
    </reference>
    <comment type="function">
        <text evidence="5 6 9">The 10-megadalton pyruvate dehydrogenase complex contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) and catalyzes the overall oxidative decarboxylation of pyruvate to form acetyl-CoA and CO(2) (PubMed:33567276, PubMed:34836937). E3BP is responsible for tethering E3 in proximity to the core, forming the entire metabolon, and the number of E3s is limited by the number of E3BPs (PubMed:34836937). Within the complex, pyruvate and thiamine pyrophosphate (TPP or vitamin B1) are bound by pyruvate dehydrogenase E1 subunits alpha and beta and pyruvate is decarboxylated leading to the 2-carbon hydrohyethyl bound to TPP. The E2 component contains covalently-bound lipoyl cofactors and transfers the hydroxyethyl group from TPP to an oxidized form of covalently bound lipoamide, and the resulting acetyl group is then transferred to free coenzyme A to form acetyl-CoA and reduced dihydrolipoamide-E2. Finally, the flavoprotein dihydrolipoamide dehydrogenase (E3) re-oxidizes the lipoyl group of dihydrolipoamide-E2 to form lipoamide-E2 and NADH. A fourth subunit, E3BP, is responsible for tethering E3 in proximity to the core, forming the entire metabolon.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Eukaryotic pyruvate dehydrogenase (PDH) complexes are organized as a core consisting of the oligomeric dihydrolipoamide acetyl-transferase (E2), around which are arranged multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide dehydrogenase (E3) and protein X (E3BP) bound by non-covalent bonds (PubMed:33567276). The Chaetomium thermophilum PDH complex contains 60 E2 units, 12 E3BP units, about 20 E1 units, and 12 or more E3 units (PubMed:33567276). The units are organized in 1 E2 60-mer, 4 E3BP trimers, about 20 E1 tetramers, and a maximum of 12 E3 dimers (PubMed:33567276). The E3BP trimers are bound inside the icosahedral core with tetrahedral symmetry (PubMed:33567276).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The sequence organization of E3BP is highly similar to E2, having an N-terminal lipoyl-binding domain (LD), a central peripheral subunit binding domain (PSBD), and the C-terminal core region connected by disordered linkers.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">E3BP is bound in a tripod-like manner and the interaction to the E2 core is primarily mediated by a loop region of E3BP (residues Pro-317 to Leu-336).</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692965.1">
        <property type="nucleotide sequence ID" value="XM_006692902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5Q0"/>
    <dbReference type="SMR" id="G0S5Q0"/>
    <dbReference type="STRING" id="759272.G0S5Q0"/>
    <dbReference type="GeneID" id="18256543"/>
    <dbReference type="KEGG" id="cthr:CTHT_0025050"/>
    <dbReference type="eggNOG" id="KOG0557">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035825_2_0_1"/>
    <dbReference type="OMA" id="DGIMMKI"/>
    <dbReference type="OrthoDB" id="202158at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF82">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE COMPLEX PROTEIN X COMPONENT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0450">Lipoyl</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0670">Pyruvate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000456223" description="Pyruvate dehydrogenase complex protein X component, mitochondrial" evidence="1">
        <location>
            <begin position="36"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="2">
        <location>
            <begin position="37"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="3">
        <location>
            <begin position="175"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="119"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction to the E2 core" evidence="6">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="site" description="E2-binding in a hydrophobic pocket in the E2 core" evidence="6">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="2">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="33567276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="34836937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="7">
        <source>
            <dbReference type="PubMed" id="33567276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="8"/>
    <evidence type="ECO:0000305" key="9">
        <source>
            <dbReference type="PubMed" id="33567276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="442" mass="46832" checksum="016F90B1862273F2" modified="2011-10-19" version="1" precursor="true">MASLAAACRVSARLAARKLQHDAAVRGFRSSAAALAAQNFMMPALSPTMTEGNIASWRVKEGERFSAGDVLLEIETDKATMDVEAQEDGILMKIIQPDGSKGVQVGTRIAVVAEEGDDITKLEIPPDEGPQQLKAAAPAPAPTPAPAPASPQPQFAAPTPSPPKASTKVPARKYPLLPSVHQLIKENGLDESAVSNITPTGPGGRILKGDVLAYLGKINPNTPAQISARFEKASHLDLSNVKVAKPVEPEKPQEEKASAPAPAPRAPEPPAKAVVSLPISLSAVLEAQQRINKKLGIFLPLSTFISRATELANEELPLPTNYQPTADELFDQVLGLDKVPGYVSAAKQRATRGNYVPDIKAPIPPKAAPKPKQKKIDIIDILAAAPKAKSVKPAGPSLVPGAVTEGLNVFSLQVPKTEERRAKVFLERVKHVLENEPGRLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5U9</accession>
    <name>G0S5U9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Methylenetetrahydrofolate reductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0033700</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2024" name="Nat. Commun." volume="15" first="5167" last="5167">
            <title>Structural basis of S-adenosylmethionine-dependent allosteric transition from active to inactive states in methylenetetrahydrofolate reductase.</title>
            <authorList>
                <person name="Yamada K."/>
                <person name="Mendoza J."/>
                <person name="Koutmos M."/>
            </authorList>
            <dbReference type="PubMed" id="38886362"/>
            <dbReference type="DOI" id="10.1038/s41467-024-49327-5"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.83 ANGSTROMS) IN COMPLEX WITH FAD AND S-ADENOSYL-L-METHIONINE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693807.1">
        <property type="nucleotide sequence ID" value="XM_006693744.1"/>
    </dbReference>
    <dbReference type="PDB" id="8UY1">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.49 A"/>
        <property type="chains" value="A/B/C/D=1-614"/>
    </dbReference>
    <dbReference type="PDB" id="8UY2">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.83 A"/>
        <property type="chains" value="A/B/C/D=1-614"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5U9"/>
    <dbReference type="SMR" id="G0S5U9"/>
    <dbReference type="STRING" id="759272.G0S5U9"/>
    <dbReference type="GeneID" id="18257408"/>
    <dbReference type="KEGG" id="cthr:CTHT_0033700"/>
    <dbReference type="eggNOG" id="KOG0564">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025841_2_1_1"/>
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    <dbReference type="OrthoDB" id="16284at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:FAD binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004489">
        <property type="term" value="F:methylenetetrahydrofolate reductase [NAD(P)H] activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
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    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Fadh2_euk"/>
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        <property type="entry name" value="Mehydrof_redctse-like"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH)"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="13 14" id="KW-0002">3D-structure</keyword>
    <keyword evidence="5 13 14" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="MTHFR SAM-binding regulatory" evidence="10">
        <location>
            <begin position="303"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="593"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="595"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <label>2</label>
        </ligand>
    </feature>
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            <label>3</label>
        </ligand>
    </feature>
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        <ligand>
            <name>FAD</name>
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            <label>1</label>
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        <location>
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        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
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        <ligand>
            <name>FAD</name>
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        <ligand>
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                <person name="Sarges P."/>
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                <person name="van Noort V."/>
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</entry>
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                <person name="Kunze R."/>
                <person name="Devos D.P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NOSIP family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693060.1">
        <property type="nucleotide sequence ID" value="XM_006692997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6A0"/>
    <dbReference type="STRING" id="759272.G0S6A0"/>
    <dbReference type="GeneID" id="18256638"/>
    <dbReference type="KEGG" id="cthr:CTHT_0026000"/>
    <dbReference type="eggNOG" id="KOG3039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053742_1_1_1"/>
    <dbReference type="OMA" id="PCVTKFM"/>
    <dbReference type="OrthoDB" id="116827at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000673">
        <property type="entry name" value="RING finger domain protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016818">
        <property type="entry name" value="NOSIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063">
        <property type="entry name" value="ENOS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063:SF10">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023577">
        <property type="entry name" value="ENOS_interacting"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="258"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="120"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="190"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="71"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR023577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS20764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="379" mass="42502" checksum="FA741481AF17E21C" modified="2011-10-19" version="1">MAHSKRNTSRPIFTSHERAMARAAWGSSSARLSRESFLPFASCWLCLEPAIDPVACSYGDIFCRECALSNILAQKKEIRRLEKMREQEERERLEEEARRDAEARERAIREFELTQLGLSIQQAGRETKSSGKDNLERSGPLKNGVVGESGQSHGEKRGEKRKFSLDADELARIAEEERIKVRKAIEEEKSSKPSLPFWAPAATPSTDSRSTEPKNKKTRPICPAAPEDNPHPYSLHSLITIKFTEETDSETKQLQRICPSCKKALTNASKAMLAKPCGHVLCRSCVGQFMKPSAADGTVRCFVCDTDVTEKPAKESEEKKEKDKIQPGLVELRREGTGFSAGGKNQNGLRMRYLQTFEMADSQSPPRQVRDNFVNLSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6K7</accession>
    <name>G0S6K7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0026560</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693114.1">
        <property type="nucleotide sequence ID" value="XM_006693051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6K7"/>
    <dbReference type="STRING" id="759272.G0S6K7"/>
    <dbReference type="GeneID" id="18256694"/>
    <dbReference type="KEGG" id="cthr:CTHT_0026560"/>
    <dbReference type="eggNOG" id="ENOG502S0CM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015358_0_0_1"/>
    <dbReference type="OMA" id="MCLESRH"/>
    <dbReference type="OrthoDB" id="4925544at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="910" mass="101363" checksum="399E17185AA58347" modified="2011-10-19" version="1">MESRSSSSSSDFPHTDHPLSQSIPIDKTEVPLSEREHRLSRSLPILRFPKPQGSQELANWISNSYQIIIQSPAMPDESNLADSAFEIIHNTDTESQDGQLTESTSSLPISRSDDVESLDGTESHYNSETDDEEALESSHASSIRYADQALQSPSPQLPASTLHHGSSTDGSGVMVGSIEFQEDNREHKSDSTILLEKISVKHAIKDFNEEESAALARTLGLPNAPKRLVVTVRQTMSQSYLSTEKPLRVLYVGRAEAQRSIILKVCNAIWVSPKNSDKDADYFNSHREGLYNIIPISSFGPNPELDLMEASHYQIKVEHCTSAHETIYEGSSFPNDTVYSITLEHDRTYTSSFSPSGSRIQPKWDLPHIAIFYCSEKDDAESTRTRDAAWAFMKRHGVPVMFIAEQQMFKNNSNGRHWNDYIDEDTPHLCLESRDSEAPMSPQRFPIDYNSFADIDARQMNRNLTYLTGRSKSDDVCEDQASSNVFPGFGLFKNWTSLKENSTVFFQRLDLAWWIFFCVFPILLPIFGSYLIDSTVGSWRSEELSGLHAVHSTGVCPTDTNSAGFTVTKQPVVATTTTTVVINVTSTKTIQVSHAKPSTSALASALSFAGFLSDKPSDVPSDTIVKTTGSTKQTLCSVRIHSPTEFLIEIPNKNKAIWLAQGAINIDVYRGDVALRTKISSVDEGVLVELSRKEAHGLLNISVVTNRRPKINETFQLDFGKASLLNTLEEGLHRIEDGVGRVCSKLGDASQALGGMVKVPNVFMSTLEHASESLCSRAADSFHQAAYSVRKKLSLRLETAKEIRKEVGFSILQAQITSRLWWLKMQGKMDEYAAYKRNASRLLKMKFGELRKGKALQEKDTPVADNRGFLRLFPNSHRTCKGECVKGVKEPFNQHATDGGNVWLKFMGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6N0</accession>
    <name>G0S6N0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YMC020W-like alpha/beta hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0026790</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693137.1">
        <property type="nucleotide sequence ID" value="XM_006693074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6N0"/>
    <dbReference type="GeneID" id="18256717"/>
    <dbReference type="KEGG" id="cthr:CTHT_0026790"/>
    <dbReference type="eggNOG" id="ENOG502QR2T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010834_0_1_1"/>
    <dbReference type="OMA" id="THPRIVN"/>
    <dbReference type="OrthoDB" id="5598028at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058934">
        <property type="entry name" value="YMC020W-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058933">
        <property type="entry name" value="YMC020W-like_ab_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47349:SF1">
        <property type="entry name" value="AER328WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47349">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26147">
        <property type="entry name" value="AB_HYDROLASE_YMC0-YMC35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YMC020W-like alpha/beta hydrolase" evidence="2">
        <location>
            <begin position="456"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS20841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="855" mass="92691" checksum="77AA8209B80326AE" modified="2011-10-19" version="1">MGGTANPAGVADFSRLESKKTPDSMSIVDDATSPTTTLSKAPKEGGSVGKARIEQHSRDSSAPSVAEAVVNHENEAKAENGVTQLVSNNDDLPKTSPPADQQQPTESPAEAQPTSIVEPAPQKPASGWFSWLGWSSNPETTASKHEPVSEPSTQNIGDPAVVGANSSQTAAPEANKAEQCTVQATSQLERRDETPSQVSPQDHSQAPEQESTPMAPKSSWFWSWSYSYWAAPTPSATSAQAEQSPGTEQSQDTKQPQTVVPLLSPQEQPKDRVVEEHSTAKPSSETPAPRSRSGTTWAFWSRDTGSGLKKGAVQRGEQGQLAVMGESSETHPRIVNSVDVKGNEAPVKEPTLKAGQKDQQKDQKKEQKKDQHKDQQKDQQQAKVDASAPSQDVPKPATRETFKSSNKRGRVQSTEAVPDASIPVPPSPPKPDAAAQSVSSKAPSISIKPAPPNLLLPSFTSTYRLKESPSILKQIARLVLRTQSSSQRHVFITNNPPKIKKALAIGVHGLFPAQYLRAMLGQPTGTSIKFANNCADAIRRWVDSHGCSDCEIEKIALEGEGKIGERVTNLWKLLMNWVDLIRQADLVIFACHSQGVPVSMMLLAKLIELGIVKTARVGVCAMAGVSLGPFPDYRSSVGRLMGSAAELWEFSDPNSEVSKRLESAVKIVLAYGARVTYIGSMDDQLVPLESAIYAPAHHPYIFRAVFIDGRIHAPDFIAHLVGFALKLRNLGVSDHGLIRELSAPLAGSLYSGEGHSRLYEDPQLYDLAVAHALETTDISGGSPPCEFRPRAPGGLSNPNPYHLPWIMRGLLEEEFVKTELATEMRELVQQFDDWKPVTKALKDVKYRLEAVRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6S0</accession>
    <name>G0S6S0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0035380</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693968.1">
        <property type="nucleotide sequence ID" value="XM_006693905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6S0"/>
    <dbReference type="STRING" id="759272.G0S6S0"/>
    <dbReference type="GeneID" id="18257576"/>
    <dbReference type="KEGG" id="cthr:CTHT_0035380"/>
    <dbReference type="HOGENOM" id="CLU_1815986_0_0_1"/>
    <dbReference type="OMA" id="PRMICAQ"/>
    <dbReference type="OrthoDB" id="5362630at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052973">
        <property type="entry name" value="Fungal_sec-metab_reg_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392:SF3">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS21672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="174" mass="20826" checksum="AE200604D49060F3" modified="2011-10-19" version="1">MDTQLDQIVIQKFLYPLREQLIKQFEKLISPPYPQHWFDIYLSSFVLLNHIEHLAKHSAFFAKLNAMDSKYSNTEFLEGVFHTAKSILARFHFVCKGWIPLRELDWNSEKVVAMADLDEDQVKFMKKTQQVVKARHDEIRQLRHTYKYEQPLYWSGQLYTEDFDKSPVRVVEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7L5</accession>
    <name>G0S7L5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0036760</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694102.1">
        <property type="nucleotide sequence ID" value="XM_006694039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7L5"/>
    <dbReference type="STRING" id="759272.G0S7L5"/>
    <dbReference type="GeneID" id="18257714"/>
    <dbReference type="KEGG" id="cthr:CTHT_0036760"/>
    <dbReference type="eggNOG" id="KOG1861">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015513_0_0_1"/>
    <dbReference type="OMA" id="RAYKPDV"/>
    <dbReference type="OrthoDB" id="199574at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.990:FF:000006">
        <property type="entry name" value="Putative SAC3/GANP domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF4">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="2">
        <location>
            <begin position="294"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS21806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="475" mass="53726" checksum="7C0300EEAE29859E" modified="2011-10-19" version="1">MMPTWPAAAPPPPVGAQPATPYAASYPLDWPDSVRRYVQRCFMPSNLDPTVSRADLESKLKETITWANEQGVMHTLDWDSMPLPQQMIRDERTRALLAPPPPPPTAQPLQQTNVQMTNEITLPVGKKRKSMDGTDVPNLSSASALPPWRTASLRLEDRVSSPSDKNMGAPDSPKQSSKFARMEKRLKRFEGEYTTYREPTPPPTAGPIVGTCQDLEKPYLRLTSAPNPAKVRPPHILRQSLELLKKKWKQDQNYGYICDQFKSMRQDLTVQRIRDEFTVEVYEIHARIALEKGDLGEYNQCQTQLKSLYKLGLKGKPNEFKAYRILYYIHTANRTELNNALADLTPAEKRDPAIKHALDVRSALALGNYHRFFQLYNETPNMGAYLIDMFVGRERLAALCAICKAYKPDVPLRFVTEELYFESDVEAAQFIIDNGGQDLLEDRNGTIVFLTAKAGQRFEGPKAAAFSRIDIKGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7S5</accession>
    <name>G0S7S5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Spo12-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0028650</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693321.1">
        <property type="nucleotide sequence ID" value="XM_006693258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7S5"/>
    <dbReference type="STRING" id="759272.G0S7S5"/>
    <dbReference type="GeneID" id="18256903"/>
    <dbReference type="KEGG" id="cthr:CTHT_0028650"/>
    <dbReference type="eggNOG" id="ENOG502SBH5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132226_2_0_1"/>
    <dbReference type="OMA" id="TKSMEYH"/>
    <dbReference type="OrthoDB" id="5578329at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007727">
        <property type="entry name" value="Spo12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05032">
        <property type="entry name" value="Spo12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="114" mass="12206" checksum="2DDCB86DF2D00EBE" modified="2011-10-19" version="1">MSGNVLAPRDANTAIPAPTDAEMATNTKPNIMSMEYHRQVFQSKMKEATENKTYISPSDNIMSPCTAKLSAFRSKQVGKVKPKSLFAQASAKSLQASANGEDVFGSKPAVPKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7V9</accession>
    <name>G0S7V9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pyridoxal 5'-phosphate synthase (glutamine hydrolyzing)</fullName>
            <ecNumber evidence="3">4.3.3.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0037170</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by PDX2. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Also plays an indirect role in resistance to singlet oxygen-generating photosensitizers.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + phosphate + 3 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="3"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694142.1">
        <property type="nucleotide sequence ID" value="XM_006694079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7V9"/>
    <dbReference type="STRING" id="759272.G0S7V9"/>
    <dbReference type="GeneID" id="18257755"/>
    <dbReference type="KEGG" id="cthr:CTHT_0037170"/>
    <dbReference type="eggNOG" id="KOG1606">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055352_1_0_1"/>
    <dbReference type="OMA" id="RYANRGW"/>
    <dbReference type="OrthoDB" id="1660966at2759"/>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04727">
        <property type="entry name" value="pdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000001">
        <property type="entry name" value="Pyridoxine biosynthesis protein PDX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01824">
        <property type="entry name" value="PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001852">
        <property type="entry name" value="PdxS/SNZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033755">
        <property type="entry name" value="PdxS/SNZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003215">
        <property type="entry name" value="PRK04180.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00343">
        <property type="entry name" value="pyridoxal 5'-phosphate synthase lyase subunit PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01680">
        <property type="entry name" value="SOR_SNZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029271">
        <property type="entry name" value="Pdx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01235">
        <property type="entry name" value="PDXS_SNZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51129">
        <property type="entry name" value="PDXS_SNZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0704">Schiff base</keyword>
    <feature type="domain" description="PdxS/SNZ N-terminal" evidence="12">
        <location>
            <begin position="17"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with D-ribose 5-phosphate" evidence="9">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="249"/>
            <end position="250"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR029271-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR029271-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS21846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="312" mass="32692" checksum="226A47BAD491E596" modified="2011-10-19" version="1">MATNLNGAVNGVGDDAFTVKAGLAQMLKGGVIMDVTNVEEARIAEEAGAVAVMALERIPADIRKAGGVARMSNPKMIKEIQEAVTIPVMAKARIGHIVECQILEALGIDYVDESEVLTPADDQYHVDKHQFKVPFVCGCRNLGEALRRIKEGAAMIRTKGEAGTGDIVEAVRHIRTVNAEIARAKAALSSGGDLAIAAMARELGCDAALLKKTAELGRLPVVNFAAGGVATPADAALMMQLGCDGVFVGSGIFKDAKDREHAASRARAIVKAVANWTDKQALIEASIEHGSAMAGISNAGLKPEEKMAGRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0S825</accession>
    <name>G0S825_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Topoisomerase 1-associated factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0029130</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Nucleic Acids Res." volume="48" first="6996" last="7004">
            <title>Crystal structure and interactions of the Tof1-Csm3 (Timeless-Tipin) fork protection complex.</title>
            <authorList>
                <person name="Grabarczyk D.B."/>
            </authorList>
            <dbReference type="PubMed" id="32469068"/>
            <dbReference type="DOI" id="10.1093/nar/gkaa456"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (3.10 ANGSTROMS) OF 1-256 AND 364-728</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the timeless family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693368.1">
        <property type="nucleotide sequence ID" value="XM_006693305.1"/>
    </dbReference>
    <dbReference type="PDB" id="6XWX">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="A/C/E=1-256, A/C/E=364-728"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S825"/>
    <dbReference type="SMR" id="G0S825"/>
    <dbReference type="STRING" id="759272.G0S825"/>
    <dbReference type="GeneID" id="18256951"/>
    <dbReference type="KEGG" id="cthr:CTHT_0029130"/>
    <dbReference type="eggNOG" id="KOG1974">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004390_0_0_1"/>
    <dbReference type="OMA" id="VNHHRHT"/>
    <dbReference type="OrthoDB" id="310853at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044998">
        <property type="entry name" value="Timeless"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006906">
        <property type="entry name" value="Timeless_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940:SF4">
        <property type="entry name" value="PROTEIN TIMELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940">
        <property type="entry name" value="TIMEOUT/TIMELESS-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04821">
        <property type="entry name" value="TIMELESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="12" id="KW-0002">3D-structure</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0236">DNA replication inhibitor</keyword>
    <keyword evidence="6" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Timeless N-terminal" evidence="9">
        <location>
            <begin position="36"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="326"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="564"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="795"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="917"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1023"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="575"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="804"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="977"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="999"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1079"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1100"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1122"/>
            <end position="1132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS21072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="6XWX"/>
        </source>
    </evidence>
    <sequence length="1212" mass="138543" checksum="44EDDF79997CC0E6" modified="2011-10-19" version="1">MEDGEVNDVVHPQVRAHINSLVSALGGISIDDDGGYKLGDDALEVLRDLKKWIRFYDEKTNRMDVARCLAEANIVSTDLLHILALWTPNENSNKYKARIALACFELMVPLTWPIEKDRETMTINHHRHIPVLQLAQLGYKRAIINYDAAPILSTAVRVALPAMAMPIGERTARDQGIIKLILYFLRNIAMITPPPGVKYEGDESQISRSALIDAFSYQDIFLTLLTIASNMGEDFRTEDVIVMEIIFHLVKRVDPKKLFVSEKQLSKIKSDELAAAMQREAAMLRSHGKNMPTRHSRFGTMIWVKRESGKLTTVSGQEALLDPAARERKMDSTKTFKPPRRARREDMEPKDLGPPVTIDERARQQLGSFVSDFLDSGFNPLFSHIRKSLEREAPHVLHYHQSQFFYLVAWFLEAERARRREKKESSKAQSGEDVSSFNLIASVLTQEMFIALNRALDRAYGDKDWRLLTSAMRCFTQILLTVQEMFDSGNDEDQEIADNILSRLFYEESTHDAVANIVRTYKDQGFEYLDACTELAHTFLRILEAYSKQNVDLQVRSRKRARRKKKAAKAAAGENGDEDQDEEDDSADDEKMAEKTSQERKFDFKRFAARFTPQGVVDTFVTFTKYYRDLDDSQLKRAHRYFYRVAFKQEMSVMLFRLDIIHLFYNMIKGPEPLDKNSPMYKEWEELVRQILKRCIRKLEERPALFTEILFSKINSTAYYLEYGFEKQTVSSNPRPGAELEFKRELSRDQQIAIAVGVLLDRNQTDHLDWIKQQLADAERERRAWENIDKAMAAERPEGEAASSEGTGFKTTPAYTTVRPDNDARRKAMFKNSHLRLLMKLCGMERLTPTLDESPDSTWIIPGIIDADTLKETLSLINKAEFNPPTFEDGQLAEHQLRRKSAAPRKRAAYDDDGSELQDFLDDGDNGILFPMGPRLKTRKRMAEDGTPPPKKRRRRRRDGSQEPEPLTEEQLEERRRARRKKQLERARRIKSAAYVNPSDDETDEEYDREFFAKEAAHQAAKDATFGLYDGLPPKPGGVERSEWEMLIGVDEEDDQPLADIERRKKSKRKPRAQSQEKSDEEDEESEEEVSDEEFEDIVSDSSSASSPSSPKRPIRLRGRTQLKQPNMSRDTGTNDESDWERDGGRDGNAMDVDPIQLSHEGPSGQEAGSTVSGGGSGAGEDEDYNDKPVAAAARSRLRARAGFIIDSSDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8M4</accession>
    <name>G0S8M4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Reticulon-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0038600</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Endoplasmic reticulum membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694280.1">
        <property type="nucleotide sequence ID" value="XM_006694217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8M4"/>
    <dbReference type="STRING" id="759272.G0S8M4"/>
    <dbReference type="GeneID" id="18257898"/>
    <dbReference type="KEGG" id="cthr:CTHT_0038600"/>
    <dbReference type="eggNOG" id="KOG1792">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046578_1_0_1"/>
    <dbReference type="OMA" id="AFPSSKC"/>
    <dbReference type="OrthoDB" id="567788at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003388">
        <property type="entry name" value="Reticulon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02453">
        <property type="entry name" value="Reticulon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50845">
        <property type="entry name" value="RETICULON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Reticulon" evidence="8">
        <location>
            <begin position="102"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="55"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="312"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS21984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="358" mass="38549" checksum="D083AB74E81C4129" modified="2011-10-19" version="1">MADVSEAFPSSKCEKFDATRPADDHESTIGGSTDEIAYAAAVAAADAADNGAASLTNGPVADHDNTSTASSAAASSTKKSDTMPLERHSSPPPYTASYRSLFAEILSWSNPQHSALAYASIVSLIVVVRYFDVLRWALKLSWMALGTAVLVETIGKAVFDASLASRLRPRTYYTISRETLDAVIGDTHELLNFFIVEGQRLLFVENVNLSVAAAVTAFISYFLVKFLPYWFLALLATTITFFGPLIYLKNQEAIDAQLKHAQDLVAAQTAQLRSVAQQHTEHAAQIAKQYAGEYTSKAQALIKGAHGRNGGAPLKAEGFPAAPKNEPFPEAPKEEPKKVEGEESESEKAGETEPLIAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8M8</accession>
    <name>G0S8M8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tafazzin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0038650</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694284.1">
        <property type="nucleotide sequence ID" value="XM_006694221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8M8"/>
    <dbReference type="STRING" id="759272.G0S8M8"/>
    <dbReference type="GeneID" id="18257903"/>
    <dbReference type="KEGG" id="cthr:CTHT_0038650"/>
    <dbReference type="eggNOG" id="ENOG502S698">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032824_1_0_1"/>
    <dbReference type="OMA" id="GTNYYSH"/>
    <dbReference type="OrthoDB" id="5278911at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="515" mass="57425" checksum="A3B76E37BF5442C8" modified="2011-10-19" version="1">MVPSLSLLSPPTAHINPIPDVQPRSVNERLAELRRSDLNRHRNSLPDSAAPTIIQPTVPPSIRQILHLPETPPPRPRRPGRTDPRTGRRLPPGPAPPRSWLTPEGRIRTALPIRPAAETSTAGATGLRCEKGDGLEFRHKVLPDLMLPGRGSLLDVALRKFAQTWEWQREVYGGFLWELPTHLRELMVFYLGVQRAGLETDDLRAVLVPSEERVWEDEDDEEERREIPQAGVLNSEFKRLDLSRSLGNCLKLRELEEFLFPPKPPPTKFTSPTDQQQEPDSWEDALDTPSQTPSPSVPLPVLPNLTHLSLALSPTSSSPVSWRHLLSLASHLPQLTHLSLAFWPVPTLTPLAAQLGASVVNTESGIAVQYGGTGFYSHTLDDDWSEAVHLLRRLSQCLYGLEWLDLTGCGAWWEALFVRVEVAPDEIDAAHQGDGDEGERGTTMVDWCGAWGKVGTVVLDPGWRVEEGKGELRRAGERSRFVELVNKAKKVEKHVRGVRRGQGRWFSVECPAVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8X2</accession>
    <name>G0S8X2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Mitochondrial chaperone BCS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CTHT_0043750</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694768.1">
        <property type="nucleotide sequence ID" value="XM_006694705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8X2"/>
    <dbReference type="STRING" id="759272.G0S8X2"/>
    <dbReference type="GeneID" id="18258413"/>
    <dbReference type="KEGG" id="cthr:CTHT_0043750"/>
    <dbReference type="eggNOG" id="KOG0743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010189_4_1_1"/>
    <dbReference type="OMA" id="YLMFWMA"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="BCS1 N-terminal" evidence="15">
        <location>
            <begin position="65"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="296"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="580"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="580"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="620"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="642"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="703"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGS19883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="751" mass="84036" checksum="3865D5E65F2FDE62" modified="2011-10-19" version="1">MDTIPSGTLEGACMAEQPSANSSMSPAIGAPNALLDFFFPGFGVLADAVVRYTGIDLNVYIPLLLLMGGVTLAWRYFTEYAWNLVDKHLMSTVDIRPDDEIYNMVMSWVANQYFAKGARRFVANTNLNSRSWHLWRREEENEEDEYEDSGEASPHRKQKPLAYTPTFGSHWFWYKGRILMFNRTQSASQAGYLTVSEREAISISCFNRNPQVLKDLLLEAREEYMKHDENKTLIYRGASRSGSISEPFWQRCMTRTARPFETVILSEKVKNELIADIADYLNPATRRWYNNRGIPYRRGYLLYGPPGTGKSSLSLALAGHFKMRIYIVSLSSVTANEENMATLFAELPRRCIVLLEDIDTAGLTHTREEGSSDEKDETLGKESNDGSLSRLGKHVLDSMKNGNSSRLSLSGLLNIIDGVASQEGRILIMTTNHLEKLDKALIRPGRIDMIVKFGKADADMTGAIFRAIYAPLEADEEPTAAASRSSSRSRALRDLDNRLLKKAVNALTPNEERKKAANDDEAQRKKEETIAKVKKLAEEFTTKIPAHEFSPAEIQGFLLKHKRDPEKAVELAEQWVIDTRKERKEKELKEAEEKRKAEEEARKKKEGREKKPKEEDEKKEKRRAKQKTKRSKKAKNTDESDASSSDSSSSFSSNEANSASEAEPKNVKSKKTITKTKQAKDTAPAAVEQSSAEVAKFESRTGQQQPVVVVPAPSMTSSVSAPPSIDTEKEKGASLDAQKTPQGADSGYGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0S903</accession>
    <name>G0S903_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Mediator of RNA polymerase II transcription subunit 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Mediator complex subunit 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CTHT_0044070</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the SRB8-11 complex, which itself associates with the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Mediator complex subunit 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694799.1">
        <property type="nucleotide sequence ID" value="XM_006694736.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S903"/>
    <dbReference type="GeneID" id="18258445"/>
    <dbReference type="KEGG" id="cthr:CTHT_0044070"/>
    <dbReference type="eggNOG" id="ENOG502QQJC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002210_0_0_1"/>
    <dbReference type="OMA" id="DRCTLFG"/>
    <dbReference type="OrthoDB" id="103819at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009401">
        <property type="entry name" value="Med13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051139">
        <property type="entry name" value="Mediator_complx_sub13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021643">
        <property type="entry name" value="Mediator_Med13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041285">
        <property type="entry name" value="MID_MedPIWI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249:SF3">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06333">
        <property type="entry name" value="Med13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11597">
        <property type="entry name" value="Med13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18296">
        <property type="entry name" value="MID_MedPIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0010">Activator</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med13 N-terminal" evidence="14">
        <location>
            <begin position="22"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="MID" evidence="15">
        <location>
            <begin position="1020"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator complex subunit Med13 C-terminal" evidence="13">
        <location>
            <begin position="1201"/>
            <end position="1477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="583"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="783"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1354"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1463"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="605"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="812"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1358"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="1383"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1398"/>
            <end position="1414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF11597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGS19914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1485" mass="160611" checksum="195CD4C95DA5ACE0" modified="2011-10-19" version="1">MDAGEYETNTLLIVSTRFPRSNLSAISFRIYEPIASQSIYTFNASDVEDALRNDGLLVYMDAVRRGIWCFYLSSNDPSTTTHPEQLGLHARMEVCGYPLGLVANGSFEPVGLFRNRPLGPNAINTPTSSSSTNSAVEVKFSFDGKAAPIPSQDFKGYSTVPVREIYEFFVKAVLSSLTTFFCRNSGAILLNHRTVLLPSTAFASGDADWNQIPKQAAVGTFRTHLTTTGSLLISLHVSLLHGMVSSADVLRSSLLSASSTVLAAPFGTFGTLQGVISTDETQAGESGSFGQYPETQVTRMRQNHTERFIQWKNTCYTLLQMKGMSPSLLDGSPWLNIHFTQRKPYDYRPDGKRTPLSSSGPTAPWPAVLCFRKPKLESMADVPFEKAFNATGIESMDPLNKAKVWCEGVSEREEALARRKKERDITAAQDHAQLADQKGQSQTNGLSPMGAWRPANGVVAGSTAGAMYPTPPDGVQQIGAAAFDAAQMQSPSGQLPSNNIAGVGDQATQVTAGQAQGQASALAPAPAAVTEPAFNSTNFPEESYYGDLGENLFEGNELTEADFENIFDEQPTSMDLYMPMLDGEPAQPAVQDNSQNQGGMEGVQMTPSQEEQGASSKPLPPVFAARPDLRPPNNNTLVNQQALQQSNTENFNRNSAIGIKRHPSPFNPETVFKRICPAFSRPPPVPLAQRSLPSRQSARHNSVFEPIEFDPSLALTSKKYGEHGLFDYRSALKNKESDAFFNVSPASTSFPTNVRQCKSQNNPPQDFGSILVKLAAGHANGSVSQKDVFSDSESSTWTSDDDEHAANDASGRASSPAKSSVLQRRRPDDDVVSIAASFRELDHLSADSPGYGPVDIARLSTAEIPELSLSRYFADPEPAPLRLSVSDADFITVAQILTEQAASGFLKLPAERPYSDLQDARRSLVKAIRYSVRGLHKALPRTLSGAVGCQLRPLAEVQDVPLMQPIGRVQVRANEVSKSSIFSIPVPHVELRRYDNQLSVLPSAVSFWETLGLGPVQGPKDIVAVCVVPQVEGMRENAAAFLDRVQSTYEVLRLGSFDRLPTSGNVVDGLVLLVTDQDVGSPGLSMNMQRSAFSHPMAKVALACASAQITEKNIVVFFAYTPEKPGSIVDACSAFQELFEHYKRFLVEKKKPVANELALQLIPLDYIVSETGLVVLTPSECARLCIETYDRCTLFGGPMPSPAILLEKALPRAIDFKLAATPSPNLLRENQCIHIAYARSIDERWVTAAWTDNRGSNQAIASYCLGRRGRPLSRPFSDVVHEIWETTQAIISTCKVHWRVIITKCGPMDPHEIELWAARAQAETRSNVSLVLLTVDTDPSLQLIPPAATIPTSAPSVFYSTPVSTPQPMSSMSPGENPPTPSGFGGSSFTPGGGGAGESSQTPGSQPQSQQQQQIDLTAGADGETTLIDPSEMTHGVLLSHRLNNSPSLTDLNPALASGYLIKRGGPRPEDLPVAMEGVRDAGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9B9</accession>
    <name>G0S9B9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fimbrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0045270</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694915.1">
        <property type="nucleotide sequence ID" value="XM_006694852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9B9"/>
    <dbReference type="STRING" id="759272.G0S9B9"/>
    <dbReference type="GeneID" id="18258565"/>
    <dbReference type="KEGG" id="cthr:CTHT_0045270"/>
    <dbReference type="eggNOG" id="KOG0046">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015284_3_0_1"/>
    <dbReference type="OMA" id="WQLMRKN"/>
    <dbReference type="OrthoDB" id="431378at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032432">
        <property type="term" value="C:actin filament bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051639">
        <property type="term" value="P:actin filament network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110009">
        <property type="term" value="P:formin-nucleated actin cable organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21294">
        <property type="entry name" value="CH_FIMB_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21297">
        <property type="entry name" value="CH_FIMB_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21300">
        <property type="entry name" value="CH_FIMB_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21303">
        <property type="entry name" value="CH_FIMB_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000042">
        <property type="entry name" value="Fimbrin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000010">
        <property type="entry name" value="Plastin-3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000016">
        <property type="entry name" value="Probable fimbrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000027">
        <property type="entry name" value="Probable fimbrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039959">
        <property type="entry name" value="Fimbrin/Plastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961:SF18">
        <property type="entry name" value="FI19014P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961">
        <property type="entry name" value="FIMBRIN/PLASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="139"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="288"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="413"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="538"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS20030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="651" mass="73050" checksum="E10DF179D213F34F" modified="2011-10-19" version="1">MSMNVLKLQRKFPQFQQNDLFSLADAFRKLDVDDKGYIDEATAIKATQASERQPYDVVRQALKEVELDSSRRVELEDYIGLIAKVRERSSSGQHSTIPASSPAAVISQRTGGHQSKGSISGGKIFVQGSNANITHTINEDERTEFTRHINAVLAGDPDIGHRLPFPTDTFEMFDECKDGLVLAKLINDSVPDTIDERVLNIPGKKHKTLNAFQMTENNNIVIESAKGIGCSVVNIGAQDIIEVREHLILGLIWQIIRRGLLGKIDIKLHPELYRLLEEDETLEQFLRLPPEQILLRWFNYHLKAANWPRRVTNFSNDVKDGENYTVLLAQIGAEYGCTRAPLQTRDLLQRAEQVLHNADKLGCRKFLTPSSLVAGNPKLNLAFVANLFNTHPCLEPITEEEKLQVEDFDAEGEREARVFTLWLNSLDVQPAVQSFFDDLRDGTILLQAYDKVIPNSVNWRYVNKPPAHGGEMLRFKAVENTNYAIELGKQNGFSLVGIQGADITDGQRTLTLGLVWQLMRKDITLTLKGLAQRLGKREITDNEMVRWANDMSRKGGRTSSIRSFKDPAIGTGVFLLDVLNGMKSSYVDYDLVTPGLTEEDAYNNAKLAISIARKMGATIWLVPEDICQVRSRLVTTFIGSLMATYERMGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9D7</accession>
    <name>G0S9D7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0045480</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694933.1">
        <property type="nucleotide sequence ID" value="XM_006694870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9D7"/>
    <dbReference type="GeneID" id="18258586"/>
    <dbReference type="KEGG" id="cthr:CTHT_0045480"/>
    <dbReference type="HOGENOM" id="CLU_1372042_0_0_1"/>
    <dbReference type="OrthoDB" id="10037289at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS20048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="199" mass="22819" checksum="95B38BA4C2151B16" modified="2011-10-19" version="1">MDAATTLAVAEHASAAENPPLQGPLLPKLLLLRLRPMRECAPCPRESSGPRSRVRTKNADIEYRELITEDPVKAYSCMCLCQPPFTKAEEEEEEEGGVNPREVFHKQFIYYRLRVPDFRMYTFNDHKGYGLIEMLQNIFLNYEKARKVGNWKRDNHIASTKNLNSIMACYIATAKKLRPYGILRSSCLQAFGLAMDKKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9T4</accession>
    <name>G0S9T4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0047090</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695080.1">
        <property type="nucleotide sequence ID" value="XM_006695017.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S9T4"/>
    <dbReference type="GeneID" id="18258747"/>
    <dbReference type="KEGG" id="cthr:CTHT_0047090"/>
    <dbReference type="eggNOG" id="KOG0920">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001832_1_3_1"/>
    <dbReference type="OMA" id="TFPVEMK"/>
    <dbReference type="OrthoDB" id="5600252at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001922">
        <property type="entry name" value="DEAH (Asp-Glu-Ala-His) box polypeptide 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000002">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF145">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX57-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="722"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="920"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="243"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="393"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="641"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="329"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="393"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="641"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS20195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1499" mass="168584" checksum="E612941362754132" modified="2011-10-19" version="1">MAPKKKSKKPVSNPARGFATTSIASKPRVAEAAPSSASTPAQSRSFNNNNKTADTDAPPKNDVPPSNSAKGATPAQNTLTAKALSPEEFEKQLEESELQLLVEKYGQTVRRLAQRQKSRLETDRRILRNGADTVNPKKWLPTELMDQILELIQAENRFAASGIVSDGATSRLPPEEDLIIKLWTLQLTLQAAGMPSNRIQPALQYVLDIAPNISLNVKGESIWGLEEVLDWFARECSLEELPDYSGRKTGSKSQADTPADTPDASRGGTPFEIDPKLGSKMKGSALNKSRQASPKRPTITVTFDEDIDPDQLLPLWLESKTKLFRIQRPRQDAAKKKGSQEKDSSSDDPEEALLLAKIDRIEKDVLFDKSVAENQWRTKKIELEREYAAAKAEERKKQADENKKKAAEEPPAPTDADEINAEAERIAAEILAEQPGDEDGALADLFASLPVNEVDPLTGKSNTVVNGADGVKVTIRDFGKWSGLTPMRVLEDACRDSSVKISYHLLSDVSYANRHAVNIIWSKPQEIPTPLELGEVEVFASPNQFVYKMMSIAAPDKKQSEAYIATVALFGIFGASANEKEDKAGNRLPQVWKDLYGELAEARKNKADQADRDVLRHLRDIVRKRVEQELEEGVLVQGFKGRGQSRNQTDSDQSDQDRARRQAVEPEYYQNIWLQKSQTPKFQKMLEYRKELPMWKAKQDVVNIVEREQVVIICEPRRISAISLARRVSEELGEDKHDLGTNRSLVGYSIRLEAKVARETRLVYATTGIVMRMLEGSNDLQEITHLVLDEVHERTIDSDFLLVVLKKLLARRKDLKVILMSATVDAEKFSNYFGGAPVLSVPGRTFPVKDLYLEDAVEYTGYTVDEQNLGGITEIDDDAEPEVDESAKPELLQELSQAGYSARTRNTLAQLDEYQIPYDLIIQLIDKISEDDSPYKMFSNSILVFLPGIAEIRELHDRLVVFKTHKDEARRRHERMHGDIRLEDNMPDDEWVVIPLHSTIATEDQEKAFQVLPRGQRKIVLATNIAETGITIPDVTCVIDTGKHREMRFDDRRQLSRLLDAFISRANAKQRRGRAGRVQEGVCFHLFTRYRYKHLMNDQQTPEMLRLSLQDLAIRVKMCNLGGIEETLSQALDPPSAKNIRRAIDALVDVRALTANTEELTPLGIQLARLPLDVFLGKLILLGAVFKCLDMAITVAAILSSKSPFQAPFGQRAQADNARMQFRRGDSDLLTAYNAYTAWKRVCQTPGASEYQFCRKNFLSEQALASIEDLKGQLLVAVADSGFLQLTSEERQALNRLRFSGRRRNQWYEVPKRVDVNSDNEVVAQSVIAWSFYPKLLVRDGNSKGLRNVGNNKPITIHPTSVNHPSKRGEAPLLRWLSYYNIMQSKSAYDARAHETTAVDPFAIVLLCGDVRADMFSGVFVLDGNRARFALPDWKTMLAVKCLRARLKEILTRNFRTPGKLPTAQQERWLEVWQKVFALAMERKLKERENGGRGSGNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9U6</accession>
    <name>G0S9U6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0047220</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695092.1">
        <property type="nucleotide sequence ID" value="XM_006695029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9U6"/>
    <dbReference type="GeneID" id="18258760"/>
    <dbReference type="KEGG" id="cthr:CTHT_0047220"/>
    <dbReference type="eggNOG" id="ENOG502S8TD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_521755_0_0_1"/>
    <dbReference type="OrthoDB" id="5417811at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="365"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS20207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="522" mass="56594" checksum="84E7A9B19D5F4BA4" modified="2011-10-19" version="1">MDRFNLFSRVREQLTSNLNNNNNTTTADNGTAIPQISIIPDSSDLQAQRSTSNNPAPEMMERPRTGLGASPSSGFRSRFRPPVFPSLLSHHHNHHNGPTTPTGPVGAGSMAHLWPQPRPTSSHYASEFDETGGGVLPGTEVDYYTGSSSSSSDSEDEYEDDIVESPKSPDFRIASPVLPGIRIDLPNLARTWSNENRRAESAGIDQHQGQGRRFIVRGGDADGKGMRARARGEVGPALCGIEAINTGITGIVNIAHEGKGEMRRPRRGNAAGDGEENVAKERAVNAPSGPRSGRERKIIGGKLREEQCLKEDPITPGEIPVLYSLDPVSPDQGSDTEGLCIGTMFEYGHGILALMLTHNIHSREVVILLVLFILFVAIVFSHSVIRLCVLLLKRRKVEEGAMREQYQNGLSTSPYAEVIIPPGGYAVPREPIPVVLARDEEAAGIESEETKLGPPAYGQWRNSVRVDPNRLFWARVPNAPATEASNSGRNSPRPPSYSSEDGIAICIYLPVITTTHVGDGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9V0</accession>
    <name>G0S9V0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LisH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0047260</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695096.1">
        <property type="nucleotide sequence ID" value="XM_006695033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9V0"/>
    <dbReference type="STRING" id="759272.G0S9V0"/>
    <dbReference type="GeneID" id="18258764"/>
    <dbReference type="KEGG" id="cthr:CTHT_0047260"/>
    <dbReference type="eggNOG" id="ENOG502R28W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008468_0_0_1"/>
    <dbReference type="OMA" id="NMAPHFF"/>
    <dbReference type="OrthoDB" id="5600002at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12610:SF12">
        <property type="entry name" value="SEQUENCE-SPECIFIC SINGLE-STRANDED DNA-BINDING PROTEIN, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12610">
        <property type="entry name" value="SINGLE STRANDED DNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="87"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="221"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="373"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="441"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="830"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="231"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="255"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="455"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="566"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="579"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="634"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="663"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="675"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="696"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="716"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="735"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="758"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS20211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="849" mass="89582" checksum="775CE0C2B3408F10" modified="2011-10-19" version="1">MASMPTMNAMGGPVNAPMNMMNHAGGAMAAPQPTTVPPRQNPPPHTHTLEAGRTLLNTYIYEYFIRYGMFDCARAVYQEDPHINVKKDSPGKMRDENGNIIGNGMGDDPMDTDSKDGIDPKRPSDLPAPNVPTPVPDSCFLLEWFCLFWDMFNSQKGKGSNGQVNQYVQHTQSRLRQEQQRDMLRQMRPDMAAQQSFQQHLMRGMPNGAMNMAMKPGSLQRAAMANSQNPQAMQMLQQKAAQMQRDPSGMDGNQRPASPSTAENAPSPSKRPRLDSGPGPFNPNQAVMMPTGRPGQGMPGQQQVGNGPDTARALLLQHGINPTSLNPQQLQAFASAVPHVQAKTLAAYATNMSQHHGNQMPNKPMGNVTGPQAQGSPMVGPGPDGNSLSQYYNPGEMGPGGMRPAGANGQTGGSNHALQDYQMQLMLLEQQNKKRLMMARQEQDMNTGSMPRTDGPGGPGGPGAPGGPGAAPGGPNAPAFQGTSPPGGRTGASPNPADQMKRPGQQLNNPANMGSPLPDGAGQQRSSPNAMNFMGTANMDPNAGPHFGMNMNMAQINGSMRPPSSHPQFNGQMNPQMIATQRQAQQPGAQGAPGMQWPQQGGPNGQMTGQPPQPQQVQGTPTPAQRAMPPPAAPAANNTTATTAPNQANARATASPQVSNAAPPTPQPAAKPPPKKKETKTAKSKTDATLKAAAQKKSNPNLNNAGATPAPEPDAPQEAPTPATPITPVNPGNFVKNQPQNPNPAGQVVPNGQPPAPQQQQQAQAPPQAAPVQASQAHNPDPNQTNFVDAETMQNFHIDFANPMQSENVIDGFDFESFIHDGNGGDDGTFDFGSGFSMDPDTTIGAGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9Z4</accession>
    <name>G0S9Z4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0040430</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694451.1">
        <property type="nucleotide sequence ID" value="XM_006694388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9Z4"/>
    <dbReference type="STRING" id="759272.G0S9Z4"/>
    <dbReference type="GeneID" id="18258081"/>
    <dbReference type="KEGG" id="cthr:CTHT_0040430"/>
    <dbReference type="eggNOG" id="ENOG502RXVZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049761_0_0_1"/>
    <dbReference type="OMA" id="DANRTHM"/>
    <dbReference type="OrthoDB" id="2367685at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="33757" checksum="56A3C77CBD382AD6" modified="2011-10-19" version="1">MQSPSLPESLPHTPQNGIPIAARRSLEDELRSLPKGWVREFDPQSQHQFFVDTNSSPVRAIWHHPYDDEAFLNSLEAEELERVKMEGLSAAVGEGTKVCVEDLIAEESDEEEGQEQTPPPSPGKGDKQRRRSSTCKLKDLLTGTSHTERQSQRAHRSALEHTLYSLHRTLRRAMSHTMITTHPFLLSRDANRTHMYLEPPGHTFPGVISTRRINPYFTEILYDREYGRKAEKSGRFFRPEGEMYGEGYGAFGCGKFAGGRWDRPEGVYRRFEGKGFGGGLGWPLKRFLRGEEVIGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0SA05</accession>
    <name>G0SA05_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0040550</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694462.1">
        <property type="nucleotide sequence ID" value="XM_006694399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SA05"/>
    <dbReference type="GeneID" id="18258093"/>
    <dbReference type="KEGG" id="cthr:CTHT_0040550"/>
    <dbReference type="eggNOG" id="ENOG502S4IY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_826395_0_0_1"/>
    <dbReference type="OMA" id="MFWIENN"/>
    <dbReference type="OrthoDB" id="15595at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018852">
        <property type="entry name" value="DUF2456"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28297">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28297:SF1">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10445">
        <property type="entry name" value="DUF2456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS19577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="336" mass="36405" checksum="D34C7884A1395A1C" modified="2011-10-19" version="1">MFWIENNSFKKFKAPADEESRKNAPAACPESGLPDPIMGPASELMEYPAGRRLLAGRHIPPPTPPTTPINSAGSPCSTVLTVLEPVPISEPDLERGATVDLDGVVPGDRFAVDARLVRVQRPTSRVTGRHGRYLAVGVLGALVISAVINFGVSYVQYAQQAPSAVSPDLFRPPMSLVADAGFTAAAQSVLTWVITLPLVNRDILGGRVAPLRLRFWGRQPQGQFRRWFLMLDHYNAHQGSWWCACQQATGCGTRLSFFLGQIVRGLLIGVLGYSILIGPGIATLMAIGTPVGNDYVFPNRWAVIIFKTVWAALLALITVPPLVVMVLVRAGWCVMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAK4</accession>
    <name>G0SAK4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Helicase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0042600</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694661.1">
        <property type="nucleotide sequence ID" value="XM_006694598.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="cthr:CTHT_0042600"/>
    <dbReference type="eggNOG" id="KOG1001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_2_8_1"/>
    <dbReference type="OMA" id="QSCNHPD"/>
    <dbReference type="OrthoDB" id="423559at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SNF2 family helicase/ATPase, putative"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF14">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="225"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="833"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="659"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1025"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="670"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="700"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="736"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="761"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="779"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="817"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1045"/>
            <end position="1056"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS19776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1056" mass="117261" checksum="32E1161D9A3D917A" modified="2011-10-19" version="1">MARSRSDSFSDDDLEILSSQAANMSLGPPPIQTPVRKSRSPSKNIPVIDLTNSPAVTPSTATKTPVAATPVPKFGHPTQLTARFGTRANDPNHMFIQRKTRPEFHADLYRSSGPLKPKTEPKKAPALPMFSSVSDEALPPEKTILSSGASYGDKVFYTDPAKAAADLKALLEGSIESEDEEVNKDKKKDENDVGDDGTLEGIKVKLLPHQVEGVRWMKGRELGPVKKGKVPKGGILADDMGLGKTLQSISLIVSNSKPALGENGWKDHFANISKATLVVAPLALIRQWEAEIKEKVSESRPLKVCVHHGQKRSTDPKVLAQYDVVITTYQTLVSEHGGSNLDPKKKPQIGCFGVHWFRVILDEAHSIKNRNAKATKACCALRAEYRWCLTGTPMQNNLDELQSLVHFLRISPYDDLTEWRQQIDLPLKNGKGHIAIRRLHSLLQCFMKRRTKDILKEEGALVAGGKKALEEAAAKAKAEGREAPEPPKSSFKVTQRKVVTIETQFSPVERKFYDLLEKRTDRSLQNMMKAGINYANALVLLLRLRQACNHPLLTDSKIEKELEALAAEVKPPSKAEAGDDDIDALADALGGMGIQTKKCDMCLNELSRREIQAGQTRCTECIESLRMVHDESPRQKKQSKEGRRISVVEEEIKIEKMPKKKQKARRIVIDSDDEDEEVEGSWLVPEDERGPLRLGKCGGEEDENAEGGGEEIGSVDSDHPSEEEEDDGSQLSSFIVDDEDVPEGELQESGSDSDSEDDTFVSVSKRSQAVPSQQASDLEASDEEEEETSGSDLDSDDSELPRLPKPAKRPFSQPMLTSSKKTTSSGSVMMSAKIREMLSILRKEAHEHKFIVFSQFTTMLDLIEPFLRNQPGLKAVRYDGKMANDAREAALHALRNDPHTRILLCSLKCGSLGLNLTAATRVIIIEPFWNPFVEEQAIDRVHRLTQTVDVVVYKLTVQDTVEARILELQEKKRKLAEAAIEMGGSTRGGKKKDALKLGLQEILELFKHDSRAALASDEGLEELERNAVVNSDTKNMIPRQKGRPKRQEHEVYGRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0SB45</accession>
    <name>G0SB45_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Aconitate hydratase, mitochondrial</fullName>
            <shortName evidence="13">Aconitase</shortName>
            <ecNumber evidence="13">4.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CTHT_0048840</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695247.1">
        <property type="nucleotide sequence ID" value="XM_006695184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SB45"/>
    <dbReference type="STRING" id="759272.G0SB45"/>
    <dbReference type="GeneID" id="18258922"/>
    <dbReference type="KEGG" id="cthr:CTHT_0048840"/>
    <dbReference type="eggNOG" id="KOG0453">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006714_2_2_1"/>
    <dbReference type="OMA" id="KKQGMLG"/>
    <dbReference type="OrthoDB" id="2224430at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01578">
        <property type="entry name" value="AcnA_Mitochon_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000003">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000004">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF3">
        <property type="entry name" value="ACONITATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="9 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="15">
        <location>
            <begin position="73"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="15">
        <location>
            <begin position="222"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="16">
        <location>
            <begin position="568"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="509"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGS19425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="764" mass="82739" checksum="14AE643808AD264B" modified="2011-10-19" version="1">MLASRQLLGVARSRALGSVGMSVRRMASVADAALDKKVRQNNWEEGNFINYKKMSENLNIVRSRLNRPLTYGEKILYSHLDDPEGQDIERGVSYLKLRPDRVACQDATAQMAILQFMSAGLDQVQNPVTVHADHLIAGRDGSEKDLARANEVNKEVYDFLASACAKYNIGFWGPGSGIIHQIILENYAFPGGLLIGTDSHTPNAGGLGMCAIGVGGADAVDLNGWTAPKDIILKLAGILTVKGGTGSIVEYFGPGVDTLSATGMATICNMGAEIGATTSLFPFNDSMYKYLAITKRQEIADFARVYAHGLRADEGAEYDQVIEINLDELEPHINGPFTPDLATPISKFAEAVKANGWPEELKVGLIGSCTNSSYEDMNRGAAIARDALNHGLKAKAIFTVTPGSEQIRATIERDGQLKTFEEFGGIVLANACGPCIGQWDRQDIKKGEVNSIISSYNRNFTGRNDGNPATHAFVASPDIVVAMTVAGKLTFNPLKDKLVGADGKEFMLSPPQGDALPAGSYDPGRDTYQAPPKDRSSVTVQVSPTSDRLQILKPFAPWDGKDAIDCPILIKAQGKTTTDHISMAGPWLKYRGHLDNISNNMLIGAINAANGEANKVKNQLTGAWDAVPAVARDYKAKGIKWVVIGDWNYGEGSSREHAALEPRHLGGLAIITRSFARIHETNLKKQGMLPLTFIDPADYDRIQPDDKVDILCTELAPGKPITMRVKPQNGAPYEIKLAHTFNEGQIEWFKNGSALNTMAKKAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBE6</accession>
    <name>G0SBE6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Iron-sulfur clusters transporter ATM1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Iron-sulfur clusters transporter atm1, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CTHT_0050000</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="19 20 21" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="4339" last="4339">
            <title>Structures of Atm1 provide insight into [2Fe-2S] cluster export from mitochondria.</title>
            <authorList>
                <person name="Li P."/>
                <person name="Hendricks A.L."/>
                <person name="Wang Y."/>
                <person name="Villones R.L.E."/>
                <person name="Lindkvist-Petersson K."/>
                <person name="Meloni G."/>
                <person name="Cowan J.A."/>
                <person name="Wang K."/>
                <person name="Gourdon P."/>
            </authorList>
            <dbReference type="PubMed" id="35896548"/>
            <dbReference type="DOI" id="10.1038/s41467-022-32006-8"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.81 ANGSTROMS) IN COMPLEX WITH ATP; MG(2+) AND GLUTATHIONE</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695348.1">
        <property type="nucleotide sequence ID" value="XM_006695285.1"/>
    </dbReference>
    <dbReference type="PDB" id="7PQX">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.08 A"/>
        <property type="chains" value="A/B=1-700"/>
    </dbReference>
    <dbReference type="PDB" id="7PR1">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.81 A"/>
        <property type="chains" value="A/B=1-700"/>
    </dbReference>
    <dbReference type="PDB" id="7PRO">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="A/B=1-700"/>
    </dbReference>
    <dbReference type="PDB" id="7PRU">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="A/B=1-700"/>
    </dbReference>
    <dbReference type="PDB" id="7PSD">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="A/B=1-700"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBE6"/>
    <dbReference type="EMDB" id="EMD-13606"/>
    <dbReference type="EMDB" id="EMD-13607"/>
    <dbReference type="EMDB" id="EMD-13609"/>
    <dbReference type="EMDB" id="EMD-13610"/>
    <dbReference type="EMDB" id="EMD-13612"/>
    <dbReference type="SMR" id="G0SBE6"/>
    <dbReference type="STRING" id="759272.G0SBE6"/>
    <dbReference type="GeneID" id="18259038"/>
    <dbReference type="KEGG" id="cthr:CTHT_0050000"/>
    <dbReference type="eggNOG" id="KOG0057">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_1_1"/>
    <dbReference type="OMA" id="VFHIIPI"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140466">
        <property type="term" value="P:iron-sulfur cluster export from the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18582">
        <property type="entry name" value="ABC_6TM_ATM1_ABCB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03253">
        <property type="entry name" value="ABCC_ATM1_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000004">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000186">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF402">
        <property type="entry name" value="IRON-SULFUR CLUSTERS TRANSPORTER ABCB7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="19 20 21" id="KW-0002">3D-structure</keyword>
    <keyword evidence="6 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="16">
        <location>
            <begin position="117"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="441"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="399"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="522"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="522"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="579"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="580"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="581"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="582"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="602"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00040792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGS19526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="19">
        <source>
            <dbReference type="PDB" id="7PQX"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PDB" id="7PR1"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="21">
        <source>
            <dbReference type="PDB" id="7PRO"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="22">
        <source>
            <dbReference type="PDB" id="7PRU"/>
        </source>
    </evidence>
    <sequence length="700" mass="77106" checksum="E88CC7FA711D1FD4" modified="2011-10-19" version="1">MSPRSRLLASSLRGGLLLRPCSARRSTLLNPSPSPLRKAIFHTTSLRAFKNLAEIATSSKEDASSLKPKGKPSPPGDPLATIEKTAAEQRRADWAIIKQMSRYLWPKDSWSDKARVLLALSLLVGGKVLNVHVPFYFREIIDRLNIDVAAVGGTVSAVAGAVIFAYGASRIGAVVSQELRNAVFSSVAQKAIRRVATQTFGHLLNLDLSFHLSKQTGGLTRAIDRGTKGISYLLTSMVFHIVPTALEIGMVCGILTYQFGWEFAAITAATMAAYTAFTITTTAWRTKFRRQANAADNAASTVAVDSLINYEAVKYFNNEAYEIARYDKALQAYERSSIKVATSLAFLNSGQNIIFSSALTLMMWLGARGVLAGDLSVGDLVLINQLVFQLSVPLNFLGSVYRELRQSLLDMETLFDLQKVNVTIREAPNAKPLALPKGGEIRFENVTFGYYPDRPILRNLSLTIPAGKKVAVVGPSGCGKSTLLRLLFRSYDPQQGKIFIDDQDIKSVTLESLRKSIGVVPQDTPLFNDTVELNIRYGNVNATQEQVIAAAQKAHIHEKIISWPHGYQTRVGERGLMISGGEKQRLAVSRLILKDPPLLFFDEATSALDTHTEQALMANINEVVKEKKRTALFVAHRLRTIYDADLIIVLKEGVVVEQGSHRELMERDGVYAELWMAQEMLHQGEAAEEPAEGEKAEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBI8</accession>
    <name>G0SBI8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydroneopterin aldolase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0053730</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695709.1">
        <property type="nucleotide sequence ID" value="XM_006695646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBI8"/>
    <dbReference type="STRING" id="759272.G0SBI8"/>
    <dbReference type="GeneID" id="18259411"/>
    <dbReference type="KEGG" id="cthr:CTHT_0053730"/>
    <dbReference type="eggNOG" id="ENOG502SSW3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062068_0_0_1"/>
    <dbReference type="OMA" id="PCLIGVN"/>
    <dbReference type="OrthoDB" id="5425486at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="246" mass="26338" checksum="5873E06538B804DC" modified="2011-10-19" version="1">MAVPLKTTPQIRALAPEPPATVCVQNLHLTLTHAGHDAWGRAGKSQPCTISVEVGFAERFSTAAASDRLGEDTVHYGTLSKVVLGSVARFEEGSRQHALGQGERGLMHVLEHVWRDLTGLKLDGTEVKVAGETPLIDIAKVQFLSLTVGLPKASLLGDGVALRASAVVDPSLRRVSARALALEITRLKVPTLIGVNANERLAKQFVVVTVTIEKFDQSEDIYPGVEAAVVKVSFGSYLDGERLWGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBK9</accession>
    <name>G0SBK9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA polymerase I-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0053950</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRN3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695730.1">
        <property type="nucleotide sequence ID" value="XM_006695667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBK9"/>
    <dbReference type="STRING" id="759272.G0SBK9"/>
    <dbReference type="GeneID" id="18259433"/>
    <dbReference type="KEGG" id="cthr:CTHT_0053950"/>
    <dbReference type="eggNOG" id="KOG2434">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010579_1_1_1"/>
    <dbReference type="OMA" id="VCSPAIV"/>
    <dbReference type="OrthoDB" id="26970at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001042">
        <property type="term" value="F:RNA polymerase I core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007991">
        <property type="entry name" value="RNA_pol_I_trans_ini_fac_RRN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12790:SF0">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12790">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IA RRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05327">
        <property type="entry name" value="RRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="305"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="645"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="649"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS18785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="683" mass="77697" checksum="621A9A0D007AA609" modified="2011-10-19" version="1">MTTLTSMARAAAGPIHSSSPIKPILRKSTSVLGTRLRSDDSDSVDDDEPPTKRQKKTVVFNEDLNTVKEISGKSLEDAKREVKHALERHNQGDDEDYDHLKELFAPNPKQSTPDDDDGTKPQDLLAYVVALTGYAPMLGRGCSGLIRSILRCSWLERDETFSRAYIQLLAAISSVQASIFTQVLTMMVDKFTETRHTSSVPGYAPVDPETKKQWLHAGLKYLLELFPAGQHIILNLISSKFPYPEESKATHMEYIGHLLRLKATRPELERDIMELILSRLVKLDVEMTLDLENDDDEITRAVLRQLEASQTTSDGDDETGDADDDDGSDSDSLLSEDELPEQAKRVLMIKNKLETMDAILDLLFSIYTPIFEDPDSPQAIEAFQDLLSDFSNVILPHLKSRHTQYLLFKFAMKSNHLMEMFIGTLFNLAPPVVKQAAVSYLASFTARGASVQSHQVQLIVQTFLDYIDHYRATHTNCRGPDVRRYSQYYAYFQGLLYIFCFRWRDLIQRDKVPPTLDWDDPSSFIGKDLPWMPGLKSRLQANIASKLNPLKCCSPVIVEEFARLSHHLGLLYIYPQIEKNKSVHLSQFFTGSYATGGALRDTGLEYDDERLTHLEACFPFDPFQLPVAKRWLDLQNSYVTWQPMAVLDRDDDEDGEDEDEDEENEGNESDEGEEEDYEFEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBY0</accession>
    <name>G0SBY0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative cytoplasm protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0055190</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WrbA family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695851.1">
        <property type="nucleotide sequence ID" value="XM_006695788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBY0"/>
    <dbReference type="STRING" id="759272.G0SBY0"/>
    <dbReference type="GeneID" id="18259557"/>
    <dbReference type="KEGG" id="cthr:CTHT_0055190"/>
    <dbReference type="eggNOG" id="KOG3135">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_526747_0_0_1"/>
    <dbReference type="OrthoDB" id="504689at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000001">
        <property type="entry name" value="NAD(P)H dehydrogenase (Quinone) FQR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019191">
        <property type="entry name" value="Essential_protein_Yae1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010089">
        <property type="entry name" value="Flavoprotein_WrbA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01755">
        <property type="entry name" value="flav_wrbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002999">
        <property type="entry name" value="PRK03767.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546">
        <property type="entry name" value="FLAVODOXIN-RELATED PROTEIN WRBA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546:SF23">
        <property type="entry name" value="FLAVOPROTEIN-LIKE PROTEIN YCP4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09811">
        <property type="entry name" value="Yae1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="477"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="252"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="478"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS18906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="517" mass="56266" checksum="E45A732B5FC5A995" modified="2011-10-19" version="1">MAPKIAIVFYSMYGHIRQLAEAEKEGVEKAGGTADLYQVPETLPQEVLDKMHAPPKPADIPILEDPSILQQYDGFLLGVPTRYGNFPAQWKAFWDKTGKQWSTGGFWGKYAGVFISTASAGGGQESTALAIISTLTHHGIIFVPLGYYPAFGLLTDLSEVRGGSPWGAGTFAGADGSRQPSDKEKELARIQGEKFYQTVAKSVEMRLHYPSEPSDRDLPFTVAVHSPDFATPHDTATHTSLDDVWADDPATIPNSPDFSQYRQPYQPEGEQSLLQRQQQQLPISDVPRLQQSYTTLGYRDGIAEGKAKTAQAGFDEGYGLGATLGARAGMLLGVLEGLVGAVGLRALQVSAAASSAAAEGTSLSAVVGRREGGQEDDDGNEGAIMRREAVRLEDLLQQARQELRIAPGGNGGVFAAEYFDLADGTWRYEVLGQEHREGEVVFADVADAHPLVRKWDWIVKAEAARYGIDWDVLKDEEVGRDEEEDDGEEDLARGGKARRERQSRSLVRNAGVPALDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBZ0</accession>
    <name>G0SBZ0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">3-hydroxy-3-methylglutaryl coenzyme A reductase</fullName>
            <shortName evidence="10">HMG-CoA reductase</shortName>
            <ecNumber evidence="10">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0055290</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(R)-mevalonate + 2 NADP(+) + CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15989"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="10"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695861.1">
        <property type="nucleotide sequence ID" value="XM_006695798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBZ0"/>
    <dbReference type="STRING" id="759272.G0SBZ0"/>
    <dbReference type="GeneID" id="18259567"/>
    <dbReference type="KEGG" id="cthr:CTHT_0055290"/>
    <dbReference type="eggNOG" id="KOG2480">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001734_0_0_1"/>
    <dbReference type="OMA" id="NDWPRAD"/>
    <dbReference type="OrthoDB" id="310654at2759"/>
    <dbReference type="UniPathway" id="UPA00058">
        <property type="reaction ID" value="UER00103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00643">
        <property type="entry name" value="HMG-CoA_reductase_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3270.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.420:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.770.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl-coenzyme A Reductase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3270.10">
        <property type="entry name" value="HMGR, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.420">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025583">
        <property type="entry name" value="HMG-CoA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004554">
        <property type="entry name" value="HMG_CoA_Rdtase_eu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023282">
        <property type="entry name" value="HMG_CoA_Rdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00533">
        <property type="entry name" value="HMG_CoA_R_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572:SF24">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13323">
        <property type="entry name" value="HPIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="NAD-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="Substrate-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00066">
        <property type="entry name" value="HMG_COA_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00318">
        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01192">
        <property type="entry name" value="HMG_COA_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0521">NADP</keyword>
    <keyword evidence="7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="12">
        <location>
            <begin position="243"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="670"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1133"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="671"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1137"/>
            <end position="1155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS18916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1175" mass="127477" checksum="CBE700B19528D29A" modified="2011-10-19" version="1">MIASNFLPSRFRGEQPQCQNAAPSWLNKKVTPLLQVLARITSTHPIHTIVIVALLASSSYIGLLEESLFDAARSVRKAEWSSLVEGSRQLRVSEDTAWKWQPYDSDAPIPPTADHLALLTLVFPEALSTDPSRAPPLANSVPIPQNLSIRPLPSTSNSFSTYSQDSALAFSIPYSQAPEFLAIAQEIPNGIPSQETRETDNGRETKMWIMKAARARTSSSIAKWFQNAWVEFTDRLKNAETLDIVIMTLGYISMHLTFVSLFVSMRRLGSNFWLATSVIFSSTFAFLFGLFVTTKLGVPISVVLLSEGLPFLVVTIGFEKNIVLTRAVLSHAIEHRRPEKSSGKSKKADASQSLIQSAIYIAIKEKGFDILKDYAIEVAFLIIGAASGVQGGLQQFCFLAAWILFFDCILLFSFYTAILCIKLEINRIKRHVEMRKALEDDGVSRRVAENVARSNDWPRADGKDQPGTTIFGRHIKSTHIPRFKVLMVSGFILVNALNLCTIPFRSANSISNISSWARGFSGLVSSPPVDPFKVASNGLDIILESAKAEGRETIVTVLTPIRYELEFPSVHYDLPQKAAKDGEEGFAIRGYGGRMVDGILKSLEDPILSKWIVVALAMSLALNGYLFNAARWGIKDPNVPDHPIDPKELAQAQTFNDTESATLPLGEYMKPPVPTPSVPPTPALSDDEAEAARKKLAAPTVPEQPQPMRSLQEMEKMLLEKRAHELTDEEVVALCLRGKIPGYALEKTLKDFTRAVKVRRTVVSRTKATADLTGFLERSKLPYQNYNWAQVHGACCENVIGYMPVPVGVAGPLVVDGQSYFIPMATTEGVLVASTSRGCKAINAGGGAVTVLTGDGMTRGPCVSFETLERAGAAKLWLDSEKGQAIMKKAFNSTSRFARLESMKTAMAGTNLYIRFKTTTGDAMGMNMISKGVEHALNVMMSEGFEDMNIVSVSGNYCTDKKPAAINWVDGRGKSVVAEAIIPSEIVKSVLKTDVDTMVELNQNKNLIGSAMAGAIGGFNAHAANIVAAIFIATGQDPAQVVESANCITIMRNLRGSLQISVSMPSLEVGTLGGGTILDPQAAMLDMLGVRGPHPTHPGENARRLARIVAAAVLAGELSLCSALAAGHLVKAHMQHNRSQPPTRSATPAPTQSAPVATGIDQRGMSAAAIERARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0SC38</accession>
    <name>G0SC38_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial</fullName>
            <ecNumber evidence="5">1.1.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Isocitric dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">NAD(+)-specific ICDH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0055800</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:23632"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.41"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Octamer of two non-identical subunits IDH1 and IDH2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.41" evidence="5"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006695846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SC38"/>
    <dbReference type="STRING" id="759272.G0SC38"/>
    <dbReference type="GeneID" id="18259618"/>
    <dbReference type="KEGG" id="cthr:CTHT_0055800"/>
    <dbReference type="eggNOG" id="KOG0784">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031953_0_1_1"/>
    <dbReference type="OMA" id="TCAHKAN"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000001">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
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        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
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    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF42">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="13">
        <location>
            <begin position="56"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS18964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="393" mass="42900" checksum="8ABF748E9D5D831A" modified="2011-10-19" version="1">MLSRNSARTAQRVLRAAAQSQQRLNVARGFASIADAPSQTVQSDIFKPTKYGGKYTVTLIPGDGIGAEVAESVKTIFKADNVPITWEQIEVSGLDEGMTAARREEKFQEAVASLRRNKLGLKGILHTPIDRSGHQSFNVAMRQELDIYASISLIKNIPGLKTRHENVDLAIIRENTEGEYSGLEHQSVPGVVESLKIITRAKSERIVKFAFSFALANNRKKVTCIHKANIMKLADGLFRGTFQRLAKDYPQLECNDMIVDNASMQCVSKPQQFDVMVMPNLYGGILSNIAAALVGGPGVVPGCNMGRDVAVFEPGCRHVGLDIKGKDQANPTALLLSGTMLLRHLGLDDHANRISNAVYDVIAQGKVRTRDMGGNASTHEFTRAILDSMEKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0SC48</accession>
    <name>G0SC48_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0055910</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695919.1">
        <property type="nucleotide sequence ID" value="XM_006695856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SC48"/>
    <dbReference type="GeneID" id="18259629"/>
    <dbReference type="KEGG" id="cthr:CTHT_0055910"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_11_6_1"/>
    <dbReference type="OMA" id="PMMLSCW"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF48">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G02700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="40"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS18974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="515" mass="57452" checksum="4F9A2891F3259805" modified="2011-10-19" version="1">MEKGNKAPFGDTRQDYKLVRFEEGDPGNPQNWSKARKWYCTMIVAITCFVVAFCSSVITSDVDGVAKEFNVSHEAALLPITVFVVGFGVGPMIFAPLSEVYGRQIIYTSTLLVAVVFIIPCAVSKNIGTLIVCRVIDGIAFSAPMTLVGGTLADLWRNEERGVPMAAFSAAPFIGPAIGPLIGGFLSDGAGWRWLYWIQLIFAFVVWVLISFTVPETYAPTILARRAAKLRKQTGDNSYITEEDLDPTPFGQKIAIFLIRPFQLLFRELIVFLISLYMSVLYGLLYMFFVAYPIIFEVRKGYSSGITGLMFIPVAVGVILSALCSPFVNNHYIKMVKKYNGKPPAEIRLIPMMLSCWFIPIGLFIFAWTSYPRLIWVGPCLAGLPIGFGFIFLYNAANNYLVDSYVHQAASALAAKTFIRSFWGAGVVLFTEQMYDRMGDQWASTFLAFLGLACCGIPFLFWKYGAAIRKHSKYAYHSDDETSDSDLDNKNIDPNAPLHHDLEDLRRARSYVSNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0SC70</accession>
    <name>G0SC70_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0056150</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695941.1">
        <property type="nucleotide sequence ID" value="XM_006695878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SC70"/>
    <dbReference type="GeneID" id="18259653"/>
    <dbReference type="KEGG" id="cthr:CTHT_0056150"/>
    <dbReference type="eggNOG" id="ENOG502SJP4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003334_1_0_1"/>
    <dbReference type="OMA" id="AVWWFLR"/>
    <dbReference type="OrthoDB" id="4356615at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056030">
        <property type="entry name" value="DUF7611"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056031">
        <property type="entry name" value="DUF7612"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056032">
        <property type="entry name" value="DUF7613"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056033">
        <property type="entry name" value="DUF7614"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24586">
        <property type="entry name" value="DUF7611"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24587">
        <property type="entry name" value="DUF7612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24588">
        <property type="entry name" value="DUF7613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24589">
        <property type="entry name" value="DUF7614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7611" evidence="2">
        <location>
            <begin position="540"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7612" evidence="3">
        <location>
            <begin position="697"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7613" evidence="4">
        <location>
            <begin position="833"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7614" evidence="5">
        <location>
            <begin position="990"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS18996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1147" mass="126951" checksum="2D45F1A2A7889C84" modified="2011-10-19" version="1">MENDHSTAIAVHDDGRVSKRGRLMGKLFGRDRKTTHDESTVAADLNDFLHGSSPDKLQVAHASPPVLSKLDTQSATRYPNSSVIRADGDTQQQELAVRQRPKKPRKPYPVRFVETYPEVIGEGGDECDIPPIEVSRRKKQRQPPQTPVTGPRSAPAETTHPQTPGGSFEPAPLRRVQTGFSPSSSPADPGRNANNNNVRHLGIPHAGQEERRKSLLEIQQAQMREAEGRAFANAVRAASGDKAKLGNGTSPSPDNDDGSPTTASVNSSAQTLQSKSSTPSSSQAPSIPPKLSAPGLQPSPILPTDKKPPTQPQNNQLLSSGSIMSSPERIRKPGQVDTSPTAPDSAASANFQHPFASLRQWSRGSDKDYPATGQSVPSAPSMHDVVVAASEEAFRAFLTRTKHLFELFRLHAESVRPLLQSAPQDLARAALWWFLTGRTALEVVIRDRPTTMTPEIEMRVERAKQQAFTDLAKGYWLVEEAMPEVINSGRSPVDREAEAVRTTLVSSLKKLTVSMKRNDIMPPEELFLPQVVDRTIWLEYPQISQDIKTLLWGLPGLAFAQNQEISSGMTILETLPLGDSATTFCFARFQVEAYLMEQGRESQRLFLPCFLSTVRPQTQSDIVFILASQNGAVQLRISGNKSHGPVWDDVRWHPETCHMEVKLPRGFLLVIKCHQQAYSTLRSMYEFSVKVHSTLYPRQDENCIFRTTLRAFQYFDNDPQARQFPKESTPNCEVALFERLHREGAATGPRTWHKGYRIAVVTGPRTKTLSGVNHTYSPQQPIQFGFLRNESNDPALSLKFDNGRFKGSMVLSFAEDKERSRMHSQLVGTALGRGEEVFGEVPLQGAWFSERFGDSLDNGLKGLSSLPWTKARVINHDNDGDRPKCVLADRLRVVYEFKDGTFTDRINVAPGELKIRLDVQNPSCLMVFRQPQADATLAITEVKSVRDVANGLAQALDTIRRLPTFRTFKFPSLEALHTFQMAITGFKVLFDGIASAFAISRRRMVVPIHKKWEAGATRIQVVQQEGVVQILAFFEDFSHGQCMGFQIKGTDVFEAFTRGGGKAGLKIVDAKFPLPKVLAPEAQDAQQVADAAFLCLDLPELPGEHDDISIVFDTDAERDRLAACLPAPVKGAKLHKLKSIGRDKGQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G0SC96</accession>
    <name>G0SC96_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Putative mitochondrial chaperone protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CTHT_0056430</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695967.1">
        <property type="nucleotide sequence ID" value="XM_006695904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SC96"/>
    <dbReference type="STRING" id="759272.G0SC96"/>
    <dbReference type="GeneID" id="18259681"/>
    <dbReference type="KEGG" id="cthr:CTHT_0056430"/>
    <dbReference type="eggNOG" id="KOG0743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010189_6_2_1"/>
    <dbReference type="OMA" id="WMTLYQR"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19510">
        <property type="entry name" value="RecA-like_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="BCS1 N-terminal" evidence="15">
        <location>
            <begin position="74"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="292"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="22"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGS19022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="519" mass="56388" checksum="B60CC3463D2CD4CC" modified="2011-10-19" version="1">MTPTSLSQAMGSPAPTMPSSQASPLNPSSTASTPSTSSPLSHLPLAAPGSTPSPSGTPLGLDNLFTNPVFAGGLGLGALGAAAAFGRRALISTAQLLRRQLLVNIEISKRDPSYPWVLAWLAQPRDDPGFLARRICRLRNLSISTTTRSLTRDEATGGGKIHADFRVQPGFGKHIIRHSPGVYIAVKREKAGTATTATGEPHETLTLTLLWMHRHVLADIFTEAHALAQQAHEGRTVVYTARRMEWAVLGQPRIKRPLGSVILDKGVKEMLVADVKEFLASQQWYVERGVPYRRGYLLYGPPGTGKTSFIQALAGELDYNVAMINLSEQGMTDDLLAHLLTQLPEKSILLLEDVDAALVNRRQRDPDGYTGRTVTASGLLNALDGLAAGEDRITFLTTNHIDRLDPALIRPGRVDMMVRIGEATRYQAAEMWDRYYGDIDTDHSGRERFLQRMDELGLFGGSETDPSVPKRHTSTAAIQGLFQFNKGNIEGAIGMVEALIPRTFEAEETSPEGTIKSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCC1</accession>
    <name>G0SCC1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-hydroxyanthranilate 3,4-dioxygenase</fullName>
            <ecNumber evidence="9">1.13.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">3-hydroxyanthranilate oxygenase</fullName>
            <shortName evidence="9">3-HAO</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">3-hydroxyanthranilic acid dioxygenase</fullName>
            <shortName evidence="9">HAD</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Biosynthesis of nicotinic acid protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BNA1</name>
        <name evidence="10" type="ORF">CTHT_0056690</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>3-hydroxyanthranilate + O2 = (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:17953"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:77612"/>
            <dbReference type="EC" id="1.13.11.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the 3-HAO family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.6" evidence="9"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695992.1">
        <property type="nucleotide sequence ID" value="XM_006695929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCC1"/>
    <dbReference type="STRING" id="759272.G0SCC1"/>
    <dbReference type="GeneID" id="18259707"/>
    <dbReference type="KEGG" id="cthr:CTHT_0056690"/>
    <dbReference type="eggNOG" id="KOG3995">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095765_0_0_1"/>
    <dbReference type="OMA" id="KPPVGNQ"/>
    <dbReference type="OrthoDB" id="204928at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000334">
        <property type="term" value="F:3-hydroxyanthranilate 3,4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:L-tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06123">
        <property type="entry name" value="cupin_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="3-hydroxyanthranilate 3,4-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="3_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="3hydroanth_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
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        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03037">
        <property type="entry name" value="anthran_nbaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497:SF1">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06052">
        <property type="entry name" value="3-HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 10" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 9" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS19047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="180" mass="20393" checksum="8A6D359E2E4A7076" modified="2011-10-19" version="1">MLAPPINLPKWLEENGHLLQPPINNFCVYNGDVTVMIVGGPNARTDYHINETPEWFYQYKGAMLLKVVDDGQFRDIIIREGDMFLLPGNTPHNPVRFANTVGIVIEQRRPPGALDRMRWYCQKCGEIVHEAAFPLTDLGTQIKEGVEKFKSDLNARTCKKCGEVADWCPKPGSIRDPNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCU9</accession>
    <name>G0SCU9_CHATD</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0050290</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006695314.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="cthr:CTHT_0050290"/>
    <dbReference type="eggNOG" id="ENOG502RJ2Q">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_458541_0_0_1"/>
    <dbReference type="OrthoDB" id="4586242at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="595" mass="63284" checksum="EF84FCBFD4AB1A27" modified="2011-10-19" version="1">MVVSTFGPKRPTSATRSAVPRQRPQRCQHSEGCGRADPASCNAQDIVVCCDEHQHSTGVIRAACGPVEGARQHANPPVPVFAATPVVTALVTAPVIAPAVLALTPSADAASKLLNAHICGSGPAGLAPAPTHATTPTPAAAPAAALFVSASAPAAFVLASVTRPYDRSSSTLSTTRVWAVWLKTKMKAGGLVVWAATPPPGVNIASSIDQGRLLTALIEPSPRQVHLPMSRNSRAWLPALLKPVLLGATPSDWSLRSLDAFERLVLTRVMALFPDLGAWLLKLRAIRREALAGDPIFAIEKLSSLPQPLQSDEDRDVLVGAVLTLGTSLYAALDMLRDLLPQDKSCDRLGEILCPTLGQLLSSLQSTLSSFEQHSCQSKKTPTDRTAPSCCRSRSPQKAPAPLSIDPAPHPSGSEPSGSSTCSTSRPDSSQAETHHRKASGLVRAIHAEMRVQAAIHVAVESLEFAERQLKLVRDLHALNGSNMEIIQKHFYEGYNRLIIRAMDLERRELGPVPDAPVTPSGSSFLPRPLLTGLLDQSPLDVRCRSVSFQHPLSVPRPSTASAVPHAGSDAWGAKSLMRRNTVEGLNQEAETVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0SD23</accession>
    <name>G0SD23_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glc8 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0050510</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695398.1">
        <property type="nucleotide sequence ID" value="XM_006695335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SD23"/>
    <dbReference type="STRING" id="759272.G0SD23"/>
    <dbReference type="GeneID" id="18259089"/>
    <dbReference type="KEGG" id="cthr:CTHT_0050510"/>
    <dbReference type="eggNOG" id="ENOG502S7WR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070379_0_0_1"/>
    <dbReference type="OMA" id="SHKSEKH"/>
    <dbReference type="OrthoDB" id="551302at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007062">
        <property type="entry name" value="PPI-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398:SF20">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY INHIBITOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398">
        <property type="entry name" value="PROTEIN PHOSPHATASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04979">
        <property type="entry name" value="IPP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="30963" checksum="1A9F7A7C8012B502" modified="2011-10-19" version="1">MTSATNPAPLHTPPGPNAPRPKGILKNKNRDAPPVSPTGNIDTAHLTPKDTKELTIANTQYNAGRRRSSSGAGARLGFRRQGSLPPKESRENGGEEQGQRLKWDEANLYLTEQERTSTMKINEPKTPYARHYDPAEDPSDEDEPLESEHADGEGSTAQSSRRRPGADDEIPGLSLGEPEEEVPEHEFAPRPRAVHVNSNESGHDADEKEYEVGLSAEEREKHRRFEEMRKKHYEMKNVAALLGHPEKLEVDDDEEEDDDEDRNAAPPVPPLPRPVNGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0SD31</accession>
    <name>G0SD31_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AP-1 complex subunit mu-1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0050630</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695406.1">
        <property type="nucleotide sequence ID" value="XM_006695343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SD31"/>
    <dbReference type="STRING" id="759272.G0SD31"/>
    <dbReference type="GeneID" id="18259101"/>
    <dbReference type="KEGG" id="cthr:CTHT_0050630"/>
    <dbReference type="eggNOG" id="KOG0937">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026996_0_0_1"/>
    <dbReference type="OMA" id="KPLIWCD"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030665">
        <property type="term" value="C:clathrin-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09250">
        <property type="entry name" value="AP-1_Mu1_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14835">
        <property type="entry name" value="AP1_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000006">
        <property type="entry name" value="AP-1 complex subunit mu-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="8">
        <location>
            <begin position="167"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS18461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="434" mass="48967" checksum="9EE7FF4F3483825E" modified="2011-10-19" version="1">MASAIFFLDLKGKTLLARNYRGDIPMSAAEKFPILLSEAEEESSAVPPCFSHEGINYLYIRHNNLYLLALTKRNTNAAEILLFLHKIVEVFTEYFKVLEEESIRDNFVIIYELLDEMMDFGYPQTTESKILQEYITQESHKLEIQARPPIAVTNAVSWRSEGIRYRKNEVFLDVIESLNLLVSANGNVLRSEILGCIKMKCYLSGMPELRLGLNDKVMFETTGRTTRGKAIEMEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTQVKPLIWVECVVESHSGSRIEYMLKARAQFKRRSTANNVEIIVPVPDDADSPRFRTNVGSVHYAPEQSAIIWKIKQFGGGKEFLMRAELGLPSVRGDDEHGGGMTGGFGGSMGGIGGPGKGAKRPIQVKFEIPYFTTSGIQVRYLKITEPKSGDIAVRLPDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G0SD88</accession>
    <name>G0SD88_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0050910</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695434.1">
        <property type="nucleotide sequence ID" value="XM_006695371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SD88"/>
    <dbReference type="STRING" id="759272.G0SD88"/>
    <dbReference type="GeneID" id="18259129"/>
    <dbReference type="KEGG" id="cthr:CTHT_0050910"/>
    <dbReference type="eggNOG" id="ENOG502SKB7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009555_0_0_1"/>
    <dbReference type="OMA" id="SACCNLL"/>
    <dbReference type="OrthoDB" id="5327538at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="664"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="413"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="838" mass="92180" checksum="CEE44A8E3A46CA4E" modified="2011-10-19" version="1">MAASNPQAFYNLWQADAIRERLFELLSKKDICAIRLANSACCNLVTKRLFLRTTLTFTANSFTRPSRIDALSRVGHHIEHLTFYFPHSNATFLPPLVHPRTGEEISFLYNPVTSLESSLTRPKYANDELAEILTQQYSPLFHAATHVPSFISAFSQLPNLRHLTVRTPGQDPSERYRRDIVDYALISLRIAVERAPLTKLSKLSLSGVHPSALHYLRHAPGGGMGTLPSAAQRWRQIRKLYISIEAWDFYGPCPGLDQLKIIDDFIRAFAAGLEKFSFSWLGRRGPCPLALANDPLFAPPRSSRKLFAEVTSPMSPLPVRPPRAMIVMPKLRYMCVKNATMNVEQLRGLVAAHKGTVREFDFDNVALIKGGSWDEALAPLTEGGKVECEGSPMAKEVWSRRSVLSIDDRPLTSKSNSASLVSSSEDEEIPTPSAAAQAASRELFEVDVIEGMLFGGLNDVEKFEQDVEAWAREVTAAAAAAAAAKPKTPEKKAAEVDDGGLASDIEAARLASESFTTKLKKRRVRKKRSNEGEQKPESGTITEQKEVREEPKSGHHGKEPRHHHRSHHKHSRSDDTSDRISRRHHRRHRRHCSEDTTASVPVALEISVPEKLPTPNASPKHTVTPHFSPSKHRPTTPELTPPAPEDERISIPILSPDALPVLLQPTVYDPSAPGKHRHRNPVLPPTPEESPSAASIPEDEKNEAAARASALQRAKEAVMTKLSKEYTHRAKEKQESEWTASAAVQASLSALNLGVKTSAESGSFLSGDLDWEKYGHGLTHTGSSGSIGSRLKEGLFGRSLASVAAAAAVCHHGNSWVSDVRGSVESQSALVPLIFSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0SD96</accession>
    <name>G0SD96_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0050990</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Clathrin-coated vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695442.1">
        <property type="nucleotide sequence ID" value="XM_006695379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SD96"/>
    <dbReference type="STRING" id="759272.G0SD96"/>
    <dbReference type="GeneID" id="18259137"/>
    <dbReference type="KEGG" id="cthr:CTHT_0050990"/>
    <dbReference type="eggNOG" id="KOG0934">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061221_0_0_1"/>
    <dbReference type="OMA" id="KAYHILD"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016482">
        <property type="term" value="P:cytosolic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14831">
        <property type="entry name" value="AP1_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000007">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044733">
        <property type="entry name" value="AP1_sigma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="10">
        <location>
            <begin position="3"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS18497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="161" mass="18870" checksum="6EC7779A8762B5BF" modified="2011-10-19" version="1">MAMHYLILLSRQGKVRLAKWFITLSPKEKAKIVKDVSQLVLARRTRMCNFLEYKDTKIVYRRYASLFFIAGCSSDDNELITLEIIHRYVEQMDKYYGNVCELDIIFSFTKAYYILDELLLAGELQESSKKNVLRCISQQDALEDMEESEKIEKALKETGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDB3</accession>
    <name>G0SDB3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase II transcriptional coactivator-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0051160</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transcriptional coactivator PC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695459.1">
        <property type="nucleotide sequence ID" value="XM_006695396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDB3"/>
    <dbReference type="STRING" id="759272.G0SDB3"/>
    <dbReference type="GeneID" id="18259154"/>
    <dbReference type="KEGG" id="cthr:CTHT_0051160"/>
    <dbReference type="eggNOG" id="KOG2712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104273_0_0_1"/>
    <dbReference type="OMA" id="NPFWELS"/>
    <dbReference type="OrthoDB" id="2505440at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.10">
        <property type="entry name" value="Transcriptional Coactivator Pc4, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003173">
        <property type="entry name" value="PC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009044">
        <property type="entry name" value="ssDNA-bd_transcriptional_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045125">
        <property type="entry name" value="Sub1/Tcp4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13215">
        <property type="entry name" value="RNA POLYMERASE II TRANSCRIPTIONAL COACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02229">
        <property type="entry name" value="PC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54447">
        <property type="entry name" value="ssDNA-binding transcriptional regulator domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcriptional coactivator p15 (PC4) C-terminal" evidence="8">
        <location>
            <begin position="44"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="104"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS18514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="157" mass="17087" checksum="4483C71F1E035135" modified="2011-10-19" version="1">MPPKKRQVEAESDKPRPKKFKPATQSAANGGLVKGTDSEGNTYWEIGHNRRVGVSKFKGTTLINIREYFTAPDGEMRPGKKGISLTLDQYKALLGAIPELNDELRSQGHAVDDPSAGETSGNAVKSEKKPKKSNIEATSEEEDDGDDGVKEEDEEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDD6</accession>
    <name>G0SDD6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication factor Cdt1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0051410</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cdt1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695482.1">
        <property type="nucleotide sequence ID" value="XM_006695419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDD6"/>
    <dbReference type="STRING" id="759272.G0SDD6"/>
    <dbReference type="GeneID" id="18259179"/>
    <dbReference type="KEGG" id="cthr:CTHT_0051410"/>
    <dbReference type="eggNOG" id="ENOG502S8WG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031309_1_1_1"/>
    <dbReference type="OMA" id="WGKRQVT"/>
    <dbReference type="OrthoDB" id="341730at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1420">
        <property type="entry name" value="DNA replication factor Cdt1, C-terminal WH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032054">
        <property type="entry name" value="Cdt1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038090">
        <property type="entry name" value="Cdt1_C_WH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16679">
        <property type="entry name" value="CDT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26121">
        <property type="entry name" value="HTH_CDT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication factor Cdt1 C-terminal" evidence="4">
        <location>
            <begin position="370"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="67"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="325"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="340"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="351"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS18537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="499" mass="55036" checksum="39BC050CCE8733EA" modified="2011-10-19" version="1">MPGLLTRKTRTPRGKLASSSAATSDITNFTKLSKQKPSGKDAPVKAQSIQDIPTTNIEVVLQPLKRKAEDAVQSTPKKLRQEPATPVSGRKKTVKFADKATPVRAPKLASLTPSSSRKRRSEDEETTDTEALLERLQLQSPVRKRTKNADTKTNLHNDFDLPQELIDLLDLHVAFLKTLSMQCVHQGMDSPIDLRTIYPSVTRTWGKRQVTLEDIQRLVGVLGWTQTKTSSTQHRTPYFLADFGRGKICIEFHADAERGPLREHKLNMDFEANLRALWQNRRDQPVTLFLGTLPKASIKACAAHIASTKTQTTLDAFKASIAAKRAEQEKEKKATNVLPTPAPSPAPSQPDTPVQQQPKQQPQFPEQKLSLLDRIRAKSLAASQQAEPTPAELQRRVALRRAADVAAVIGMLSKASTSAGQARVSFTMAHVQARLRDSLRASPMSVDDAAASVRLLATEVAPQWLRIVTLGGRENVVISVAMQPTKGQVEERARQLLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDJ5</accession>
    <name>G0SDJ5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0052010</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695541.1">
        <property type="nucleotide sequence ID" value="XM_006695478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDJ5"/>
    <dbReference type="GeneID" id="18259239"/>
    <dbReference type="KEGG" id="cthr:CTHT_0052010"/>
    <dbReference type="HOGENOM" id="CLU_1234865_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="224" mass="23905" checksum="C9798DC676350A6A" modified="2011-10-19" version="1">MPNCQGHHHLGAAGRLRMILSQASPPNPPRLHLNEGEAPHANPKGEDPGLPAQRREADRHIPAALALDPGASRPILEAPAHHPEPGLSTPVVQALLLERLRNSTPATVRHAARRSSRHHRDVIANRRRAQGGGFVLHFPSGLHLPDAIAGLLGDLDTSDVPMIEHMVAGIRTEGGAGPDQGRHQGVGRERGGMRARIIGIVMSEAGGIRPRQCLVSSLQSAREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDL7</accession>
    <name>G0SDL7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinetochore protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0052230</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695563.1">
        <property type="nucleotide sequence ID" value="XM_006695500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDL7"/>
    <dbReference type="STRING" id="759272.G0SDL7"/>
    <dbReference type="GeneID" id="18259261"/>
    <dbReference type="KEGG" id="cthr:CTHT_0052230"/>
    <dbReference type="eggNOG" id="ENOG502S9QD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058478_0_0_1"/>
    <dbReference type="OMA" id="KQHNRIV"/>
    <dbReference type="OrthoDB" id="21214at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031511">
        <property type="term" value="C:Mis6-Sim4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025207">
        <property type="entry name" value="Sim4_Fta4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42040">
        <property type="entry name" value="INNER KINETOCHORE SUBUNIT FTA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42040:SF1">
        <property type="entry name" value="INNER KINETOCHORE SUBUNIT FTA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13093">
        <property type="entry name" value="FTA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="29492" checksum="40A3925E5DD4C4FF" modified="2011-10-19" version="1">MADSTPTVVFLKQSFLNAQTRLLSQPLAPSRTWRNANSNGEDNASPLPDKAIDDALFKLNNRLQQHARRVYPPQATRHVAEQIDALYWNAAEAATRGGEDDEGGDLDEGIEKSLRKGADFADPSVIATLPLTWEAPTQEEEADEEAIARYADLAAQLHELAKRKTDALARVERLRRMQTLLAPFDATSPSNNESTGSMDGVQENLVTRNGEIETELARMRMLLARVAGRIPRLKERRGDQEEEDEAGVDVEMEEQKKIGALLDKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDV4</accession>
    <name>G0SDV4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0053120</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695650.1">
        <property type="nucleotide sequence ID" value="XM_006695587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDV4"/>
    <dbReference type="GeneID" id="18259350"/>
    <dbReference type="KEGG" id="cthr:CTHT_0053120"/>
    <dbReference type="eggNOG" id="KOG4157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116866_0_0_1"/>
    <dbReference type="OMA" id="RECWCAQ"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051836">
        <property type="entry name" value="Kremen_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269">
        <property type="entry name" value="KREMEN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269:SF16">
        <property type="entry name" value="PROTEIN SLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409053" description="WSC domain-containing protein" evidence="7">
        <location>
            <begin position="23"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="8">
        <location>
            <begin position="37"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS18705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="172" mass="18396" checksum="2FFB2F3C3AA8859C" modified="2011-10-19" version="1">MHSFLTPFLFFILLLTPILTLAQQQKPSIYIPPSKSGYTYLGCYNETTDLPDTAGLRALNGGKNVVKPGEMTVNMCLEFCSTGAGDSKGGNTAMFEYVGLEYSRECWCARSLSGLSEKFPDDACNLPCDGNATQICGGNLKLTVYKAGTMKSLASLSAAGLAAVMTMISILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0SE37</accession>
    <name>G0SE37_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0062290</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. gTMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696545.1">
        <property type="nucleotide sequence ID" value="XM_006696482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SE37"/>
    <dbReference type="STRING" id="759272.G0SE37"/>
    <dbReference type="GeneID" id="18260267"/>
    <dbReference type="KEGG" id="cthr:CTHT_0062290"/>
    <dbReference type="eggNOG" id="KOG1269">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039068_1_0_1"/>
    <dbReference type="OMA" id="YCLPYVI"/>
    <dbReference type="OrthoDB" id="506498at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025774">
        <property type="entry name" value="PiNMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF11">
        <property type="entry name" value="GERANYL DIPHOSPHATE 2-C-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51581">
        <property type="entry name" value="SAM_GTMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="SAM motif I" evidence="4">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="SAM motif III" evidence="4">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="171"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS18214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="40842" checksum="D5F3D7F10BBE69AD" modified="2011-10-19" version="1">MPASSSLPDAPTELSKKYETSLGIAHTTMQALKDRIRLHYDLASDYYLNLWGEHIHHGYWPTPESKNTDSKETAQVNLIKLLLDISQLSPSDNHPNPNGGETMKTSPPSLRILDVGCGLGGTSRYLASTLGAAVTGITISGKQVQMATRLSKKVAAAAPTGNVADISAAAADDDDDNDNDDDDDDGFIPLAGGGKVRFLELDAEKMGEHFSGSSQASGSDGDDSRKFDIVWITEALSHFPDKGLFFRNAQSLLRKGGKLVLADWFKAEGLEKELLEKDIKPIEDGMLLPPLCTQQQYVELGTDAGLEVLSPPKDISQDVSKTWEISWSLVQNPSLWAFAFSQGRDGIAFLQAFRAMRRGYANGSFRYAVMAFKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0SE94</accession>
    <name>G0SE94_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0062940</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696602.1">
        <property type="nucleotide sequence ID" value="XM_006696539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SE94"/>
    <dbReference type="GeneID" id="18260332"/>
    <dbReference type="KEGG" id="cthr:CTHT_0062940"/>
    <dbReference type="eggNOG" id="ENOG502R6U7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_388826_0_0_1"/>
    <dbReference type="OrthoDB" id="4588689at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="710" mass="77262" checksum="9FADDA9C037FB6F8" modified="2011-10-19" version="1">MSKDHKDLKGRAETLRQLQRKDSLTSLLSWTAGRTGIGIPVARPSTAPASYSPSSTNANPPESGSFNSNHNNSKQRRHSHSGHTNSSGSFTIDVKKKARIESGTVRLLASINPAFQQRPSAKTRPAKTSPVVSLKEDNNSDKMSVKTAIKSDSEKGSAPSAGARRPNTPVRYKYPHHSPQRPKSILRNPKPDVSKRPRTPSASSSSEEPGQTTPPLSPSSSTTTSSDAPATPPLSPSLNNKFPQSQTQNKTPREPTVRFAKATIHHIEVYSPGAKLLPVKRKSRSTLSYLDPSWRSLPKNLTQNPVKWRRHQENQKAMGRYWRRTEEEEQMWRREMERRAEEEARAYRSEPAARPGSPELNIWVNGGKLASAVVDDKWPLASETEEEELREQDEEKDKLEEVLAEDEDEVDKLEEVLAEEEKTRGPEQSLDEKKQEDEVSGTKSKSQTDEQTQPTQQHKPQAAPTLDHPTNSYLPLTEPPQLSSPTSEHQQHSTSPSSPSSTESTSPPPNWNPSSTPLKINPFSKPSDERLPLLERRASAPALTALRTSSSRYRSLSRSPARMERTHMGMASPVLKPIAMSVPVPTGTTITTTTSANGVTTTTVTYPTITTTTAGSTYTTTMTVGPAAPSAGPAVYGPGALLSQELIPSPSVSPISSPTLGPIPGSPMLGPMAGLNLNGSASASGSGLNMASPRMHLRKSRLRNAITAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEH4</accession>
    <name>G0SEH4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative voltage-gated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0063760</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696682.1">
        <property type="nucleotide sequence ID" value="XM_006696619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEH4"/>
    <dbReference type="STRING" id="759272.G0SEH4"/>
    <dbReference type="GeneID" id="18260414"/>
    <dbReference type="KEGG" id="cthr:CTHT_0063760"/>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_1"/>
    <dbReference type="OMA" id="EQPAYNM"/>
    <dbReference type="OrthoDB" id="1720422at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150:SF6">
        <property type="entry name" value="VIC POTASSIUM ION CHANNEL, BETA SUBUNIT (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01577">
        <property type="entry name" value="KCNABCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="25"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS18351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="347" mass="39428" checksum="C58AC5F4F7D92DB0" modified="2011-10-19" version="1">MAKPDNLPEMEYRFLGRSGLQVSAISLGGWLTYGGHVDREGTFACMKAAYDCGVNFFDCAEGYADGESERVMGEAIRKFGWKRNDLVISTKLYWGAAFSDRKINNVGLSRKHVIEGMDASLKRLGLDYVDLIYAHRPDRHTPMEEIVRAFNHLINTGKALYWGTSEWDADEIASAWRWADKLNLIGPLMEQPRYNMLERFQVEREYAHLYREVGLGLTVFSPMRQGILSGKYKNGIPEGSRFAQTQVEFIAGFWKQTGKEEWQAIIEQVKKLEPIAERLGVKQSVLALAWVLANPNVSSAITGASSPEQIYENMEALRVYKKLTPEIMAEIDEVLNNKPPEVMMRFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEN2</accession>
    <name>G0SEN2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0064350</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696740.1">
        <property type="nucleotide sequence ID" value="XM_006696677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEN2"/>
    <dbReference type="STRING" id="759272.G0SEN2"/>
    <dbReference type="GeneID" id="18260473"/>
    <dbReference type="KEGG" id="cthr:CTHT_0064350"/>
    <dbReference type="eggNOG" id="ENOG502QV0U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003608_0_0_1"/>
    <dbReference type="OMA" id="LWVTVKP"/>
    <dbReference type="OrthoDB" id="47488at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04486">
        <property type="entry name" value="YhcR_OBF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42834">
        <property type="entry name" value="ENDONUCLEASE/EXONUCLEASE/PHOSPHATASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G09210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42834:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G09210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409510" description="Endonuclease/exonuclease/phosphatase domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="298"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS18409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="616" mass="65909" checksum="299C9E7282E9E7F3" modified="2011-10-19" version="1">MKPTMRALVWALASLQSLAVALTIAEINGNRFISPYAGQTVTNVTGLLIAKGPSGIWIRSTTPDRDPATSEAIYVYSSSVGAKLSVGDIISMDGKVSEYRSSESYIYLTEITSPKNVQVLSSNNTVKPLIIGKDTFSPPTVQYSSLDRGDIYSVPNAVANISEVNPVLQPSKYGLDFWESLSGELVTVRKPKVIKTPNKYGDTWVYGDWVVSGKNSHGGLTMTNKEAIIIGSPLDGTKNPTTSKMGDQLEDIIGVVQQAYGFYSILPLTAVKVKVNASVAASPTSLRSRGQCNAITVGSYNVQNLAPTSAHLPKVAAHLVNYLHTPDLIFIQEVQDDSGPTDDGVVSANATLTALTNAIYELSKVKYSFASVDPAPGNLDGGQPGGNIRQAYLYRPDVISLYKPNQGGANDATQVVPATKSKGSTVTGPSLSFNPGRIEPASDAWKGSRKPLAAAWTAKKAKKPFYTVNVHWSSKGGGTSLHGDIRPPINGALNVRITQANVTGTFISKILALDPSANVIAAGDFNEFAFVQPMKRFSSVSKMVDLDEVAGIPANERYTYAYDMNAQALDHMYVSPAIAKTRSVKFEHVHVNAWAAYDDVVSDHDPSVALLNLCGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEU0</accession>
    <name>G0SEU0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">General alpha-glucoside permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0059690</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS17956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696287.1">
        <property type="nucleotide sequence ID" value="XM_006696224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEU0"/>
    <dbReference type="GeneID" id="18260007"/>
    <dbReference type="KEGG" id="cthr:CTHT_0059690"/>
    <dbReference type="eggNOG" id="KOG0637">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018303_0_0_1"/>
    <dbReference type="OMA" id="IYTTIPQ"/>
    <dbReference type="OrthoDB" id="28755at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008506">
        <property type="term" value="F:sucrose:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432:SF76">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13347">
        <property type="entry name" value="MFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="497"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="556"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="420"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS17956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="581" mass="62698" checksum="2C1D62FDEBE72B96" modified="2011-10-19" version="1">MSTWAGQPHVKGSTETMRMVLLTCVSIGITFTWGVEMTYCTPYLLSLGLTKGQTSLVWLAGPLSGLIVQPIIGVIADESTSKWGRRRPIIVIGSAIVAMSLVTLGFTKEIVGHFVTDPDIARSLTIMLAVLALYTVDFSINAVMSCARSLVVDTLPIHKQQTGAAWLSRMNSLGHIIGYAMGAIDLVRLFGPRLGDSQFKQLTVIAALGMLSTAGVTCWAVTERVLLSVRPDPRRSTGRFKIVRQIWSTLLTLPPRIRGICNAVFWSWIGWFPFIVYSSTWVGEMYFRHDVPPEARNSHDALGEMGRIGSMALTVYSTMSFLSAWILPALIRSPEDEMPPAYTPRPPTSLAPYIEAFNKVKPDLLTAWIASCVLFAGAMFLTPFATSFRLATAIVALCGIPWSISQWAPVTFLGVEVNKMSSSSPFTRPPSSPPYYHRRRDSNDGTTASSENSIELLTLEHGPATTANSSAASSGLLEAGALSHGGSSSSTGELSGIYFGILNIYVTIPQFLSTLMSGIIFAVLEPGKSPELAGHGHGAVMDDTTHGPDPSKGPNAIAVCLLLGAISSLVAAWTTRKLRWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0SF16</accession>
    <name>G0SF16_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0060460</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696363.1">
        <property type="nucleotide sequence ID" value="XM_006696300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SF16"/>
    <dbReference type="STRING" id="759272.G0SF16"/>
    <dbReference type="GeneID" id="18260084"/>
    <dbReference type="KEGG" id="cthr:CTHT_0060460"/>
    <dbReference type="eggNOG" id="KOG0742">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004471_6_0_1"/>
    <dbReference type="OMA" id="VALHYKN"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056599">
        <property type="entry name" value="AAA_lid_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF2">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23232">
        <property type="entry name" value="AAA_lid_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7025" evidence="3">
        <location>
            <begin position="221"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase AAA-type core" evidence="2">
        <location>
            <begin position="500"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase lid" evidence="4">
        <location>
            <begin position="624"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="674"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS18032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="736" mass="83634" checksum="C904747DE231C6AF" modified="2011-10-19" version="1">MADTEPDYSSDSSIPGYSRIPRRSLGDTNSHLSKRERELRAMIDSLPGKPVYGPDEVPEILYTTRFFDNNNRYVECRLVLEIKTDLHPHGRHGGIRGGGGYLPPLLPLPDPNKFPHEAMSGRTVMHIHSHYLRCALAAVATYYPGFESILHSGKIEPPYRVLVHLWKDLEAYRDNQPACHDEDWRATTARHIDVLLGFLREQYADALELERKSRWENPSGEPTATWDMFWVLLAPGTVVYVNNERDGRMLMPGVVHEVKYRESWTGHGGLYEVWVWNVRWKMGRLRRSCVPVHVEAWNGERPIRSLPVIPERFVPGGPEDVRRKMVRLGEMFWELAKQPTYKEYDRPVWWRRGRATRGPYSPPYPYDSDDDDNSPYRRRTSSGRHSGDMRIAARRAALPELQASCPCLACILAGVKPGPSPWDGFESRDPKTEELPANRELYLMLISPFIPAFLLGFRRWGYVNVSHIRPVVPNPSIFDSLILPAEIKATASAASSFCTAPPGVGKTCTAECAAELTHRPLLALTAGDLHNVDWKGDVEAALHYFLHLGERFGALVLLDEADVYLERRSSGSEDLKRNEMVSVFLREMEYFKGVLFLTTNRVEVFDEALVSRVHVALRYEELGVEERAKVWEGGFGRLERETSAESPYRYIAPPSTRSYVTSDPEVRAAAAAAEGKQAASGENQTSQLAAVDGEKSEEKEKKEPLTVVIKPEHIRAVVRMTRGFKEFMQGIRERQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFH2</accession>
    <name>G0SFH2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidyl-prolyl cis-trans isomerase-like 2</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
            <ecNumber evidence="7">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Cyclophilin-60</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Cyclophilin-like protein Cyp-60</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">RING-type E3 ubiquitin transferase isomerase-like 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CTHT_0070810</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EC" id="5.2.1.8" evidence="7"/>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697355.1">
        <property type="nucleotide sequence ID" value="XM_006697292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFH2"/>
    <dbReference type="STRING" id="759272.G0SFH2"/>
    <dbReference type="GeneID" id="18261119"/>
    <dbReference type="KEGG" id="cthr:CTHT_0070810"/>
    <dbReference type="eggNOG" id="KOG0883">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_7_0_1"/>
    <dbReference type="OMA" id="NFIKHCA"/>
    <dbReference type="OrthoDB" id="407558at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01923">
        <property type="entry name" value="cyclophilin_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16663">
        <property type="entry name" value="RING-Ubox_PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000079">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000014">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase cyp65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026951">
        <property type="entry name" value="PPIL2_U-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF1">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN-PROTEIN LIGASE PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0697">Rotamase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="19">
        <location>
            <begin position="46"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="18">
        <location>
            <begin position="337"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="252"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="502"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="502"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="544"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00020592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGS17737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="601" mass="65985" checksum="3F6367254EE9F1A6" modified="2011-10-19" version="1">MGKGTDKLYITHSEWSSGDAYSASVGANAGERARRAAGGAALASFSRLPFNYCAASLQPFKNPVCTADGTIFDVEVIGAWLAKHNTNPVNGKPLAAKELIKLNFARSPDNPDTYCDPVTFKPFTNNTHIVAIRHGTYANVFAWETIERMNIKAKMWRDLVDDAEFGRKDIITLQDPQNAAARDLSQFKHLQEGGEGALPTKELEAQRAEGNINIDALGRLGDKVLRAKEAVARARQAREATGDVNHVTKALTASSKSSSATPTPRIGTPSQATSTKPKPPPNAARYTTGRAAASLTSTSLTPSTSSHELALLTDEEYMLKPKRVKHKGYVRIDTTCGPLTIELHTETAPQAVWNFIRLSQRGYYRGVLFHRNIANFMIQGGDPTGTGKGGQSIWGKNFPDEVDGPNSLHDGRGVVSMANKGKDTNGSQFFITYRAAKHLDRKHTVFGRVVLEDEHGKRTASADTLDTMEKWPTDGRTNRPIKEIVMRDVVVLIDPFEEFMKERKEQEDKEEGEKKKKLENKEDDVTTWTGKRVRSRYDPNHGNGDAGSGGGGGGVEVGKYLKNIQQRQQDEGGGGEVDTWEEPVRKKTKIISGGFGNFDNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFI4</accession>
    <name>G0SFI4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Ornithine aminotransferase</fullName>
            <ecNumber evidence="4 9">2.6.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0070940</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 2-oxocarboxylate + L-ornithine = L-glutamate 5-semialdehyde + an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:13877"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="EC" id="2.6.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.13" evidence="4 9"/>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697367.1">
        <property type="nucleotide sequence ID" value="XM_006697304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFI4"/>
    <dbReference type="STRING" id="759272.G0SFI4"/>
    <dbReference type="GeneID" id="18261132"/>
    <dbReference type="KEGG" id="cthr:CTHT_0070940"/>
    <dbReference type="eggNOG" id="KOG1402">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_3_1"/>
    <dbReference type="OMA" id="RSAWDLC"/>
    <dbReference type="OrthoDB" id="10261433at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004587">
        <property type="term" value="F:ornithine aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019544">
        <property type="term" value="P:L-arginine catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010121">
        <property type="term" value="P:L-arginine catabolic process to proline via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000011">
        <property type="entry name" value="Ornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000152">
        <property type="entry name" value="Ornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010164">
        <property type="entry name" value="Orn_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01885">
        <property type="entry name" value="Orn_aminotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF18">
        <property type="entry name" value="ORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS17749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="447" mass="48895" checksum="97127294600FCF41" modified="2011-10-19" version="1">MAPHAEESTRPHPVPQQKQDRYHSPSTTTAITSENTHAAHNYHPLPIVFSRAQGVHVWDPEGRQYLDFLSAYSAVNQGHCHPALVQALSEQASRLTLSSRAFHNDVFPVWAEKVTKLFGYDMVLPMNTGAEAVETAVKVARKWAYKVKGVPQGKAMVWSVEGCFHGRTMTAVSLSVDPESRENYGPYLPGVGAVNPKTGKPIRYNMVEDIEEVLNEFGKETAAVLVEPIQGEAGVVVPDEDYLAKVHALCKKHNVLLICDEIQTGIARTGRMLCSEWSGIRPDMVTLGKAISGGMYPVSCVLADKHILGVVEPGTHGSTYGGNPLGCAVSIRALELVIEEGMVEKAERLGRVFREGIEAIKSPIVQCVRGKGLLNAVVIDESKTEGRTAWDLCLLLKEKGVLAKPTHGNIIRFAPPLVITEEQLRWALEKIAEALKELPTAPKSEDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGA0</accession>
    <name>G0SGA0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0065580</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696857.1">
        <property type="nucleotide sequence ID" value="XM_006696794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGA0"/>
    <dbReference type="STRING" id="759272.G0SGA0"/>
    <dbReference type="GeneID" id="18260596"/>
    <dbReference type="KEGG" id="cthr:CTHT_0065580"/>
    <dbReference type="eggNOG" id="ENOG502R95R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_594466_0_0_1"/>
    <dbReference type="OrthoDB" id="4828117at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="460" mass="48803" checksum="3DBDA404D63CB88A" modified="2011-10-19" version="1">MSRTTNFRSYDAQARLLAALVASLENQRFDFKKHRMRTVKAMAEACRKLVEAGEDPAQYAIYEHFDTKQKIQKYFGASTPDGIGFQFRSVKQGAKVLIDAVNNGKDPVQAFNEWNNGGSSSIPATPAGRGAKRARAPSMKKTPGTTPASKRRKQIKLEDITDDEDSPDADYSDLDTTPTKNKPISGAKKINDVDLTADDNLDKPAFSTKSTLNKLVKADCAAHEATAGGIHAVCETGTSSKGAVAAQAPTTDQDSGPQQDDDVLVAASSFTLPPIPGTGSSSTADVSTLDAQNTSLFNLPPARPPIIPSLASFPDNVKYASPNSAARSILTSSAPISSNTTVTINGSKAKGFKPDSEAPSTTVSLSQCQSRSCSKTPVQAMSQSFTFENESEPEVTNSAGEALDLHDTYRSVVRGRRSESVATYFTAVDSATGQSHAGTGSVNFDSHDVDGDDEWDAGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGD5</accession>
    <name>G0SGD5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">14-3-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0065930</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696892.1">
        <property type="nucleotide sequence ID" value="XM_006696829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGD5"/>
    <dbReference type="STRING" id="759272.G0SGD5"/>
    <dbReference type="GeneID" id="18260631"/>
    <dbReference type="KEGG" id="cthr:CTHT_0065930"/>
    <dbReference type="eggNOG" id="ENOG502RZWE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036650_0_0_1"/>
    <dbReference type="OMA" id="HLWGSHS"/>
    <dbReference type="OrthoDB" id="5370350at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="33002" checksum="28C55E1AF23B4033" modified="2011-10-19" version="1">MASSEVDQKFLGRLAKAVERDNPLLSSVLFKILGLSINLSGQLIKARKQRRPDGTYPPEATDLICHIIWLSREGLVLLQQYVLPMVGNYVELKVLAYKLRASFYHIFVLFHNTPPISSITAANTPDTQSVSGHPSSSRVDKGKGIARDDLYDASKSSVGPPPGFEHPPPPTAFLLKPGNYLPEAHQYFREAVQLAEELLWGSHSLRLSVKTEYAAFLYECVRDPEASRKLARDTIAEVYEATEGIDNDMFNDACELVTVLGKMMKRGLGSSNNTLKGKNSPAVGVQGTPPGVGREPPPGMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGI0</accession>
    <name>G0SGI0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0066400</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696937.1">
        <property type="nucleotide sequence ID" value="XM_006696874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGI0"/>
    <dbReference type="STRING" id="759272.G0SGI0"/>
    <dbReference type="GeneID" id="18260678"/>
    <dbReference type="KEGG" id="cthr:CTHT_0066400"/>
    <dbReference type="eggNOG" id="KOG0048">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046302_0_0_1"/>
    <dbReference type="OMA" id="QPMNIPF"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050560">
        <property type="entry name" value="MYB_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614:SF25">
        <property type="entry name" value="MYB PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614">
        <property type="entry name" value="MYB PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="12"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="13"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="62"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="62"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS17319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="330" mass="37205" checksum="7C94C88DA0F52F54" modified="2011-10-19" version="1">MAPTPAPYPGGHKRGPWSQAEDTRLLLLIGESNQHPNWVKISNAMGTRTPKQCRERFHQNLKPGLNHSPISQQEGEQIEALVREIGPKWAEIARILGTNRCDNAIKNWWNGAQNRRKREERREARVQQLEQMKQQQRQQQQQQQQRHHSVSGPVSYRTLPDPRRTSITLPPPYSLSHSSSSSISSYRIETPLPSPSPISLPSERELFQTPSQPQPQPQYQSRQRSPPSFPPLMIPGEGAVLPGRDWTPPPTSKLPPLNSIVPLPSPGSASPQAPVSPRQYYHQPQQQGIDAYPSRHWLPTAPNSPADVHRPVSKPRDEEYKSIPVSSLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGR4</accession>
    <name>G0SGR4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Apurinic-apyrimidinic endonuclease 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0067280</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AP endonuclease 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697021.1">
        <property type="nucleotide sequence ID" value="XM_006696958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGR4"/>
    <dbReference type="STRING" id="759272.G0SGR4"/>
    <dbReference type="GeneID" id="18260766"/>
    <dbReference type="KEGG" id="cthr:CTHT_0067280"/>
    <dbReference type="eggNOG" id="KOG3997">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025885_1_2_1"/>
    <dbReference type="OMA" id="DEGCQSH"/>
    <dbReference type="OrthoDB" id="7663182at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00019">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.150:FF:000001">
        <property type="entry name" value="Probable endonuclease 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00152">
        <property type="entry name" value="Nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00587">
        <property type="entry name" value="nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002199">
        <property type="entry name" value="PRK01060.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445:SF0">
        <property type="entry name" value="APURINIC-APYRIMIDINIC ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="ENDONUCLEASE IV ENDODEOXYRIBONUCLEASE IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00729">
        <property type="entry name" value="AP_NUCLEASE_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00730">
        <property type="entry name" value="AP_NUCLEASE_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="10">
        <location>
            <begin position="134"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="423"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS17403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="469" mass="51358" checksum="9C055C4A3502ABD5" modified="2011-10-19" version="1">MVRRSARNAAKEPATTTTTTTTTDPHEEAIKTETNGAEADSEELKQRNKRKASASEPKPQSVDSPEADSPEEEESKPEPKKRKTTSSTKLSSQQEQTEMPLAPRTAVNTLRRAMYIGAHVSAAGGVHNSIPNAIHIGANAFALFLKSQRKWTSPPLADDAKNQFHALIKQHGYDATKHVVPHASYLINLAQADAAKAKQAYDCFLDDLKRCEALGIGLYNFHPGSAGPGGDMKAACGRIAAQLNKAIKATKSVVVLLENMCGSGNVVGGRFEELADIISQVEDKSRIGVCLDTCHAFTAGYDLRTPEAFAQTLAEFDRTIGLKYLKALHLNDSKAPYHSNRDLHANIGTGFLGLRAFHNIMNCPTLENLPMVLETPIEEKDAKGKTVENKQIWADEIKLLESLIGMDVESEEFNRLECELQKKGAAERRRIEEQVEKKATKEKKKLDGGKKERGAMDAFVVKKKGEGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGT2</accession>
    <name>G0SGT2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Karyogamy protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0067470</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697039.1">
        <property type="nucleotide sequence ID" value="XM_006696976.1"/>
    </dbReference>
    <dbReference type="GeneID" id="18260785"/>
    <dbReference type="KEGG" id="cthr:CTHT_0067470"/>
    <dbReference type="eggNOG" id="ENOG502QUB2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005577_0_0_1"/>
    <dbReference type="OMA" id="AANIHNA"/>
    <dbReference type="OrthoDB" id="5559380at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051293">
        <property type="term" value="P:establishment of spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031578">
        <property type="term" value="P:mitotic spindle orientation checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030473">
        <property type="term" value="P:nuclear migration along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013889">
        <property type="entry name" value="Karyogamy_KAR9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37271">
        <property type="entry name" value="KARYOGAMY PROTEIN KAR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37271:SF1">
        <property type="entry name" value="KARYOGAMY PROTEIN KAR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08580">
        <property type="entry name" value="KAR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="316"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="884"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1121"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1279"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="740"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="175"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="322"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="884"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="897"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="914"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="970"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1017"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1060"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1135"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1181"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1206"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1284"/>
            <end position="1295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1302" mass="140924" checksum="45A4D79A2A71F6B4" modified="2011-10-19" version="1">MSDPAAAAAAPSSESGDNNNNNANTGTTASNDNTVDTIDDTCNTNQTAVPLLDIAIAPPVLEISEIADAIPSPGPGSDHNHDHDRNAIRSESGHDAASNANAEQSSLTSSDISVSVSVALSVPSESEPDQSCDATATNHDDNIQHRTLGEHQNQTAAASPSCPGLPPKPAPYQPQQPQSAQQQSLQPLLQHSKQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQKPNGLTTAANIHNATTPHNLPHPLGRKSPPPSRQIEPGRLPEEQLRKLDEHLFAKPTAPVIEKRGRPWKGTKAAIARIPSFSSLKSDKSQGGKSESEVEPSQTQTSTAAPSPEFLPEIPATEPLDNLMDTNKYRLPDHTNGNGVKAQPDTRGAHIARDTRPPPLEDDDDVPPPPLPKDTPPQSRRSSVVSPGTVSTTTSREPFNENIPFNPLGLKRPGSVYTLSRASFASQIAQLTSIQLPDAESLSSRVAAIPTAQMAAKALLGAAEQIRGWIYKASEVIDGLEADDDVEWAAAGGREGVEEVENAILRFEELIKIYVGAIEELQAREDITAVPPEDLKRAVSQMEGITAEWARIHKTLKGVKTQVEIAMEWEELWNNVIGDIQHEMDDLSRLVFELEEKRHRSCVALVGDGPDVPDLDTLIEEPRTSTVHLQPTPNHRFSMTALPISPTSPSFNAATPPQDDSSLLALFARMQPLRASLDFLPMRLSVFQARAEKIFPTACEELETRRLELDESYRKLERDAENLRKELGEDRWVLVFRSAGRQAQKMYESVERSVHKVREGVEARLYLTNPLAWGKSLESYEAKKTHYGPAIERVLGIVDKGLSDRLTVNGEIVRLHVDMQARWAQLKEQIGELDAALEEIQAEREHRRTEQQLRDSVSSMLSGELSSALASGNETPQTSPPSSVIMPVTARKSGLQPPKQRSASALGHTTPAAKRHSMLPTPSSKLSSRKPPAFPASSSSSSSSTLSVPFSRESAVTPTTQRTTSRPPSSLATRPRWNSSTNTNDLDVGHNFKPLTLTTPSPYAKKTTLQGAGRSISVPATPSSSTSKLPLPQHHPLARSPLIRATSASPIPEEALLNGSAGNTPSSSSQNLSFRERLAGSAAKPRLARGEPLSASSSDLSISTTASSATKSSRRASVQPQSARLPPLDFSKPDVPPRRPASSLAHHYPPSSSSSHLVGAHYPPSASRSRSSTRATSTTGQSRRASVLSSSTSTSATGTGTPARSPFRGSVIGLNEGQVGVGVGGRVSPQALAGARVAMSRGASRQGQYPSVQQEKPRWRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGY4</accession>
    <name>G0SGY4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nicotinamide N-methyltransferase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0068000</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697091.1">
        <property type="nucleotide sequence ID" value="XM_006697028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGY4"/>
    <dbReference type="GeneID" id="18260838"/>
    <dbReference type="KEGG" id="cthr:CTHT_0068000"/>
    <dbReference type="eggNOG" id="KOG2920">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032409_2_1_1"/>
    <dbReference type="OMA" id="RARWCIV"/>
    <dbReference type="OrthoDB" id="407325at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF104">
        <property type="entry name" value="N-METHYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="38466" checksum="CA83F59D0D48A5B3" modified="2011-10-19" version="1">MSLISRISLTGPETSDPEDLLSDSLGVVFPDDVTNQHGDSHHGLLYTSPYLPNPIQLALAQVENDSDRRLFSHYLWNSSLLLAELIEAGTLGLSLPQPSEELMGSEANDGSSIEATSTDDQDLKKLKRRHLGPPVSLFDITGLSTIELGAGTALPSIMAGLIGARRVVITDYPSKPVLKTLQENVKGAIQAKNAPSGRFAVDPETTDVLVAGHAWGEFDTPLAKENWHAFDRVISADCLWMPWQHENLRRSIEWFLNEDENARAWVVAGFHTGRQKMRGFFDKEALAAVGLEVEYLWERDCNGMDRPWAWDRGIESISVRKRWLAIGVLKRIRKSTENGGQENRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGZ7</accession>
    <name>G0SGZ7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein SSH4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein ssh4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CTHT_0068130</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Components of the endosome-vacuole trafficking pathway that regulates nutrient transport. May be involved in processes which determine whether plasma membrane proteins are degraded or routed to the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SSH4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697104.1">
        <property type="nucleotide sequence ID" value="XM_006697041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGZ7"/>
    <dbReference type="STRING" id="759272.G0SGZ7"/>
    <dbReference type="GeneID" id="18260851"/>
    <dbReference type="KEGG" id="cthr:CTHT_0068130"/>
    <dbReference type="eggNOG" id="KOG1477">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016552_1_1_1"/>
    <dbReference type="OMA" id="FFFKYTR"/>
    <dbReference type="OrthoDB" id="258495at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12910">
        <property type="entry name" value="SPRY_SSH4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000065">
        <property type="entry name" value="Ear1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035780">
        <property type="entry name" value="SPRY_Ssh4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="18">
        <location>
            <begin position="78"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="311"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="326"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="409"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="470"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGS17486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="486" mass="53075" checksum="D72D15F0CD72A12A" modified="2011-10-19" version="1">MAGYNSGLNGVIIGLLSSFGSALLVLCILLVFYFFRYTSSGRIFLDRIGRPGEYDDEQAFAREEAEALETMDDMQRTEYLRAKAFIAANPPESVPTDISLSQYLAIQEKGVSAWEFEPELEIANCFVEARTEIEFFDSECTVMSNLPVPKQNDVYYWEAKIYEKPETTLISIGMATKPYPLFRLPGYHKQSVAYFSNGTRRFNQPFSATPYGPAYQQGDVIGVGYRPRTGTIFFTRNGRKLEDVVHGLKSPNFFPAVGAIGPCVVHVNFGQAGFVFIEANVKKWGLAPMTGSLAPPPPYGAEEDTILLETGTKDGFNSGPYRGHHYSQSAQPYRPGTNQLDPGHSRSRSGNFRVLPPVSPGPPRSPTDISLAHLVPTDDSAEASSSTAALVRPYGPADIPNDPPPEYTSPDHSDTEDNGSRRSGGRGETAPLLSRSRGNSLAGSRVAPSTSRAPPSPPIPSYQDAIRQGAGHDRSDSVRSERADSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHN6</accession>
    <name>G0SHN6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0072800</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS16956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697538.1">
        <property type="nucleotide sequence ID" value="XM_006697475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHN6"/>
    <dbReference type="GeneID" id="18261318"/>
    <dbReference type="KEGG" id="cthr:CTHT_0072800"/>
    <dbReference type="HOGENOM" id="CLU_088026_1_0_1"/>
    <dbReference type="OrthoDB" id="5387389at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052635">
        <property type="entry name" value="Sec_Metab_Biosynth_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607:SF2">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607">
        <property type="entry name" value="XANTHOCILLIN BIOSYNTHESIS CLUSTER TRANSCRIPTION FACTOR XANC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS16956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="175" mass="18865" checksum="950B6A72A5A303FD" modified="2011-10-19" version="1">MAPSRTTRTGSTSTAPRKASSNRRLTDDWTEVTEPEERRRIQNHIAQRKFNLAFEDTDLAGLPWGGLSIRHVVARGHAEASTGTLSHHSGHSDTLSVTAGLPGSGMMTPAPASSPMPPQTPSFFYTAADQQQQMLYGLDSYGAYSSAHHHAATTAAINMMFDSQRDGLGDVRGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHS2</accession>
    <name>G0SHS2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0073170</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS16992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697574.1">
        <property type="nucleotide sequence ID" value="XM_006697511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHS2"/>
    <dbReference type="STRING" id="759272.G0SHS2"/>
    <dbReference type="GeneID" id="18261355"/>
    <dbReference type="KEGG" id="cthr:CTHT_0073170"/>
    <dbReference type="eggNOG" id="KOG1206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040078_3_0_1"/>
    <dbReference type="OMA" id="FKHTDQE"/>
    <dbReference type="OrthoDB" id="60204at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044594">
        <property type="term" value="F:17-beta-hydroxysteroid dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03448">
        <property type="entry name" value="HDE_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054357">
        <property type="entry name" value="MFE-2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13078:SF57">
        <property type="entry name" value="DEHYDRATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13078">
        <property type="entry name" value="PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22622">
        <property type="entry name" value="MFE-2_hydrat-2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peroxisomal multifunctional enzyme type 2-like N-terminal" evidence="2">
        <location>
            <begin position="18"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="MaoC-like" evidence="1">
        <location>
            <begin position="176"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS16992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="310" mass="34081" checksum="73B016E848AE3172" modified="2011-10-19" version="1">MSKGPGVGFQYPPVPVSWTKRDALLFANSIGCTSKELHFLYELDPNFAVFPTYPVILTFKGTSNEVIDFYAQQKAVPIPGVPTFDPTRVVDGQRLLQSFKPIPTSSEGRNFEIRTTVLGVYDKGRPGTVVETQSDLVDVATGEVYSRVISSSFFVGQGLWGGPSGPKQVTYTVPKDRKPDVTFEHQTSPETSLLYRLNGDYNPLHAHPEPGKKMGFGGIIIHGLWTWNWAAHGLLEHLGGSNPANLKEYQARFASPVRPGDKLVASAWRTGQYQGEFEEIRFEVRVAGGKVVLSNGRALIKTAAGKENKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHU5</accession>
    <name>G0SHU5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">P/Homo B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CTHT_0073410</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S8 family. Furin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697597.1">
        <property type="nucleotide sequence ID" value="XM_006697534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHU5"/>
    <dbReference type="STRING" id="759272.G0SHU5"/>
    <dbReference type="MEROPS" id="S08.070"/>
    <dbReference type="GeneID" id="18261379"/>
    <dbReference type="KEGG" id="cthr:CTHT_0073410"/>
    <dbReference type="eggNOG" id="KOG3525">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002976_2_1_1"/>
    <dbReference type="OMA" id="PWMHVKH"/>
    <dbReference type="OrthoDB" id="300641at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007323">
        <property type="term" value="P:peptide pheromone maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04059">
        <property type="entry name" value="Peptidases_S8_Protein_convertases_Kexins_Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000026">
        <property type="entry name" value="proprotein convertase subtilisin/kexin type 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000005">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034182">
        <property type="entry name" value="Kexin/furin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF14">
        <property type="entry name" value="NEUROENDOCRINE CONVERTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 14" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409593" description="P/Homo B domain-containing protein" evidence="17">
        <location>
            <begin position="19"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="709"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="18">
        <location>
            <begin position="475"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="646"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="751"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="646"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="672"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="758"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="789"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="844"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGS17015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="864" mass="94612" checksum="5F8F5C64B6C9E69E" modified="2011-10-19" version="1">MKLSSAFAFLGLVAGAISAGIAPRDWDNNDYYVLHLDPNTSPDDVAKALGLRHEGPLGELRDHHVFVAKKDDQDIVKRQLKERKKRRALGERHVLDGVLFSQKQRLRSPWQKRIPPVRQGPAPLRPRDSPDETAVQLQKDIANVLGIHDPIFNEQWHLFNTVQVGHDVNVTGLWLQGVTGKNATVAIVDDGLDMYSNDLKDNYYAAGSYDFNDKTEEPKPRLSDDKHGTRCAGEVAAVRNDVCGVGVAYDSKVAGLRILSKLISDADEAVALNYDFQHNQIYSCSWGPPDDGRSMDAPGILIRRAMLNAIQNGRGGLGSIYVFASGNGAQNDDNCNFDGYTNSIYSITVGAIDRRGLHPHYSEKCSAGLVVTYSSGSDDYIHTTDVGPNMCARTHGGTSAAAPLAAGIFALVLQVRPDLSWRDMQYLAMDTAVPVNLDEPDWQTTAIGKKFSHTYGYGKLDSYAIVEAAKTWKKVKPQAWFFSPWIHVKKPIPQGDQGIAVTFEVTEQMLKEANLERVEHITVTMNVEHGRRGDLSVDLISPHNVVSHLSVTRKFDDATTGYDDWTFMSVAHWGESGVGTWTIIVRDTIVNSFTGTFIDWHLKLWGECRDPAKAKLLPMPTEDEDDDHDAIPTTTVGSLFTTSAPANAHPTSSIPESALNHQPTRPVKGGKPTSTSTAGSEQPTEAAASQNNWLPSFLPKFGVSASTQAWIYGSLVLIILFCSGLGIYLWLARRKRLRNNPRNDYEFELLNDQDDVDGPGGDAEKGVGGAGTGKRRTRGGELYDAFAGESDEESDEVEAGGVYRDHPEGSGGSGSPIRVGEKLPAPARARRDSDEESGQHVIGDSDDEEESDDVQARPLQRGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHX6</accession>
    <name>G0SHX6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pescadillo homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Nucleolar protein 7 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">NOP7</name>
        <name evidence="8" type="ORF">CTHT_0073720</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="10 11 12" key="2">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e56910" last="e56910">
            <title>Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation during pre-60S biogenesis.</title>
            <authorList>
                <person name="Lau B."/>
                <person name="Huang Z."/>
                <person name="Kellner N."/>
                <person name="Niu S."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
                <person name="Cheng J."/>
            </authorList>
            <dbReference type="PubMed" id="37129998"/>
            <dbReference type="DOI" id="10.15252/embr.202356910"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <reference evidence="13 14 15" key="3">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e57984" last="e57984">
            <title>Structural insights into coordinating 5S RNP rotation with ITS2 pre-RNA processing during ribosome formation.</title>
            <authorList>
                <person name="Thoms M."/>
                <person name="Lau B."/>
                <person name="Cheng J."/>
                <person name="Fromm L."/>
                <person name="Denk T."/>
                <person name="Kellner N."/>
                <person name="Flemming D."/>
                <person name="Fischer P."/>
                <person name="Falquet L."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="37921038"/>
            <dbReference type="DOI" id="10.15252/embr.202357984"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.12 ANGSTROMS)</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the pescadillo family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697628.1">
        <property type="nucleotide sequence ID" value="XM_006697565.1"/>
    </dbReference>
    <dbReference type="PDB" id="8I9P">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="CJ=1-679"/>
    </dbReference>
    <dbReference type="PDB" id="8I9R">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="CJ=1-679"/>
    </dbReference>
    <dbReference type="PDB" id="8I9T">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.60 A"/>
        <property type="chains" value="CJ=1-679"/>
    </dbReference>
    <dbReference type="PDB" id="8I9V">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="CJ=1-679"/>
    </dbReference>
    <dbReference type="PDB" id="8I9W">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="CJ=1-679"/>
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        <property type="resolution" value="2.63 A"/>
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        <property type="chains" value="CJ=1-679"/>
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        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="CJ=1-679"/>
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        <property type="resolution" value="2.12 A"/>
        <property type="chains" value="CJ=1-679"/>
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        <property type="chains" value="CJ=1-679"/>
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        <property type="method" value="EM"/>
        <property type="resolution" value="2.19 A"/>
        <property type="chains" value="CJ=1-679"/>
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    <dbReference type="AlphaFoldDB" id="G0SHX6"/>
    <dbReference type="EMDB" id="EMD-17950"/>
    <dbReference type="EMDB" id="EMD-17951"/>
    <dbReference type="EMDB" id="EMD-17952"/>
    <dbReference type="EMDB" id="EMD-17953"/>
    <dbReference type="EMDB" id="EMD-17955"/>
    <dbReference type="EMDB" id="EMD-17956"/>
    <dbReference type="EMDB" id="EMD-17969"/>
    <dbReference type="EMDB" id="EMD-17970"/>
    <dbReference type="EMDB" id="EMD-35279"/>
    <dbReference type="EMDB" id="EMD-35281"/>
    <dbReference type="EMDB" id="EMD-35283"/>
    <dbReference type="EMDB" id="EMD-35285"/>
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    <dbReference type="EMDB" id="EMD-35287"/>
    <dbReference type="EMDB" id="EMD-35288"/>
    <dbReference type="EMDB" id="EMD-35289"/>
    <dbReference type="EMDB" id="EMD-35290"/>
    <dbReference type="SMR" id="G0SHX6"/>
    <dbReference type="STRING" id="759272.G0SHX6"/>
    <dbReference type="GeneID" id="18261410"/>
    <dbReference type="KEGG" id="cthr:CTHT_0073720"/>
    <dbReference type="eggNOG" id="KOG2481">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019619_1_1_1"/>
    <dbReference type="OMA" id="QKVTWIV"/>
    <dbReference type="OrthoDB" id="10264910at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17709">
        <property type="entry name" value="BRCT_pescadillo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000056">
        <property type="entry name" value="Pescadillo homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010613">
        <property type="entry name" value="PES"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221">
        <property type="entry name" value="PESCADILLO - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221:SF6">
        <property type="entry name" value="PESCADILLO HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06732">
        <property type="entry name" value="Pescadillo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="10 11 12" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="BRCT" evidence="7">
        <location>
            <begin position="362"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="314"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="472"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="506"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="526"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS17046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="8I9P"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="8I9R"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="8I9T"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="8PV1"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="8PV2"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="8PV3"/>
        </source>
    </evidence>
    <sequence length="679" mass="77057" checksum="33F0A32B880677FD" modified="2011-10-19" version="1">MGKAKKKGKSGAARNYMTRTQAVKKLQLSLPDFRKLCIWKGIYPREPRDRRKVNKSATASTTFYYTKDIQYLLHEPLLQKFREQKALEKKISRALGRGDVSNAARLERNANLPEKTGKPRYTLNHIIRERYPTFQDALRDLDDCLSMLFLFANLPSTTAVPAKMIARCERLCHEFQHYLIVTHSLRKSFLSIKGIYYQANIQGEDILWLVPYKFNQRIVGDVDFRIMGTFVEFYMTLLGFVNYRLYTSIGLKYPPKFDQVKDDQGAELAAFSLEGLNLASQNGEQKAITNGEEHGPDPKVQAEVDKLVAKLREEEQQANGDKTDEKGEENEGDDKPSDAIDKFEPVAPGGDVLPQPSYSSSDPSQLFANFTFFLSRETPRQPLEFILRAFGCKRIGWDAVLGEGAFTTDESDPRITHQIIDRPVIRAAVSEDGDGEDNQTSQKLAPNGRYPGRIYVQPQWVWDSINDEELKPPELYAPGAQLPPHLSPFVKPTQGQYDPTKPLEEQQTEAEALEAELEDAQAQQEGSDEESGSEVENDMSVASDEEDEQEDDFGGFSDEDEEQSDEGSEEGDEEEDDDEEEEATLERQRELEAELAGKAVSKGKPLDPKVKAKLEAKKALERKKKQEAEELERAKGMLSKKKRKLFEQMQYSNAKKNAEDAKLRAKRRRIEKEMAAKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHZ0</accession>
    <name>G0SHZ0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0073880</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697642.1">
        <property type="nucleotide sequence ID" value="XM_006697579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHZ0"/>
    <dbReference type="STRING" id="759272.G0SHZ0"/>
    <dbReference type="GeneID" id="18261426"/>
    <dbReference type="KEGG" id="cthr:CTHT_0073880"/>
    <dbReference type="eggNOG" id="KOG0086">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_6_0_1"/>
    <dbReference type="OMA" id="HRFVKSE"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="327"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="221"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="38630" checksum="62A4DE33D144377D" modified="2011-10-19" version="1">MSSYELPGLGRPRRSSAGSEESMSTVREQEQELGSMYDYLAKVILLGPSGTGKSCLLHRFVKNEWRVLSSQTIGVEFASKIIKVGTGARRKRIKLQLWDTAGTERFRSVSRSYYRGAAGAVLIYDITSRLSFNNLQPFLNDARALASPNLSIVLVGNKLDLADSPHPPGLNIGMSIPPPTPSTVSLASSYTSANTAIPPSSSGASYSSSVASTIHPHSHSTHNSSLGSGSTTTATAGGGPGQWRATVAPDGREVSAVEAARWASTVGIPVTMEVSAFSGEGVDEVFGRLARMILAKIELGEIDPDDPMSGIQYGDAPAVWGGMSDADGGSVRSGVTGDGSEGIGRRRRRRRGGGTGQALREWEEMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHZ5</accession>
    <name>G0SHZ5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0073930</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697647.1">
        <property type="nucleotide sequence ID" value="XM_006697584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHZ5"/>
    <dbReference type="STRING" id="759272.G0SHZ5"/>
    <dbReference type="GeneID" id="18261431"/>
    <dbReference type="KEGG" id="cthr:CTHT_0073930"/>
    <dbReference type="eggNOG" id="ENOG502RZMU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042688_3_1_1"/>
    <dbReference type="OMA" id="KPWAKVD"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF4">
        <property type="entry name" value="7ALPHA-CEPHEM-METHOXYLASE P8 CHAIN RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="329" mass="37483" checksum="A27688B3B2445811" modified="2011-10-19" version="1">MTTASINYLDPTTVPAGTKPWAKVDAPATSYGIVSRRRSITSIRDCLTLHTSSQRGAFGTDIDIAGFAVYTSPSPYYAKYGSAGFTQELDRQIREGYYPEVEELLRRKLRDGNKIRHVVIFDHTIRRKDPNAPRQPVYRLHVDQTPRSAEARVRRHAGKALGLSEEEVEGLLKRRWQPINVWRSIGEQPVRDAPLTVVDFRTVNREKDLVAVNLLYPVRPKDGDDDDDRGKEVLPDLEKLQSTEGYEVKGETYAVQPNEEHKFYYLDEMTPEEVMFIKCFDSWGEDQPGGKKGIAGLTPHTAFLDEMAPEGTKPRESIEVRCLVFYDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0SI60</accession>
    <name>G0SI60_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aspartic-type endopeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0074610</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697712.1">
        <property type="nucleotide sequence ID" value="XM_006697649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SI60"/>
    <dbReference type="GeneID" id="18261499"/>
    <dbReference type="KEGG" id="cthr:CTHT_0074610"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013253_0_1_1"/>
    <dbReference type="OMA" id="TKATFDW"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06097">
        <property type="entry name" value="Aspergillopepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000024">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000026">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034163">
        <property type="entry name" value="Aspergillopepsin-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF2">
        <property type="entry name" value="ASPERGILLOPEPSIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409290" evidence="8">
        <location>
            <begin position="21"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="9">
        <location>
            <begin position="102"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="340"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS17130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="419" mass="44797" checksum="B0E61369AEBD8E06" modified="2011-10-19" version="1">MVRVTFTIALVLGYMTGTFPLETSLRSDDTHHTGGGKTFSVRQVSNPDFIRSGPYQLAKAYKKFGVPLPEDLKNALGRLRLEKRKRSTGNEVTKPESYDVEYLTPVSIGTPGQVLHLDIDTGSSDLWVFSSETPSNLVNGQSLYEPAKSSTAQKLEGYTWKISYGDGSSSSGVVYRDSVTLGGLTVSSQAVEAATQVSEEFTSDSNNDGLLGLGFGSLNTVQPKGQKTWFENIMQELDSPIFTADLKAGEPGTYNFGYIDKNAHIGNISYVSVNDSNGYWTWTSPGYAIGTGALVSTQIMGIADTGTTLLLLPSTIVVMYYAQIPGALYDATQGAYTLPCSPTPPDFSFAVGDDGQVITIPGEYILYAAITSIGTMCFGGIQADSGIGFSIFGDVALKAAFVVFDGGKKRLGWASKDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0RXR5</accession>
    <name>G0RXR5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative FAD binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0000120</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988030">
        <property type="protein sequence ID" value="EGS24081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690567.1">
        <property type="nucleotide sequence ID" value="XM_006690504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RXR5"/>
    <dbReference type="STRING" id="759272.G0RXR5"/>
    <dbReference type="GeneID" id="18254050"/>
    <dbReference type="KEGG" id="cthr:CTHT_0000120"/>
    <dbReference type="eggNOG" id="KOG1336">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_360923_0_0_1"/>
    <dbReference type="OrthoDB" id="5043642at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF11">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408597" evidence="1">
        <location>
            <begin position="19"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="2">
        <location>
            <begin position="454"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS24081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="775" mass="84935" checksum="73AB761FD5A30245" modified="2011-10-19" version="1">MTALILLGLILCVVTALAAFSPRGLLLWLLGLLGRESLLPPSSVKPDVEKKPSSESWPPIEPLPDFDWKTTPPIKLRPFKPIYHINMAIQSTTPSELIVLDNTYLTKVLERRSILSSHGPSVHGAIPSGSAPVHELYTYLLGTYLPTRYPRLFSVSQTEKGTLTFHNHVTGLTAPVCPSEQEMDAEAMLRILGETVEDDLFLLLQDPAEQGGQHRAVAFVCCHPAGFAPREKLGMRLGEIHGPVPGIEKISGSMERFFSRLEVGKPVKRVNWTLQTTPHLFTPRGSGVTLHLDDAVQEVEKIDPSQARMRVELQTLTRLPQSRAILFSFKSFMYPLEEIKAEGLGPALADAVEGLQKGNVPGMWIYKGAVMSENAPQAESEKDKMSALSNVVVVGGSYVGLPRFSILPSHEHKAFIPYTSTYTSSPDPSRHLILHARATALHPHTLTVDRPIFQSSTSVPFDYLILATGSKLPPPGNIPLSVTDSLNNMTHHGKNEKENAARYLRQWQSAIKQADTIVLVGGGAVGVQMACDIKEIYPHKQVTIVHSRDRLMNAFHPWLGEIVDERLRELGVRVEKGVRVVFPEGGFPDPTTTTGSNSTPKTNMTEVRLTDGRCLKADLFIPCTGPKPSTSLLTSPSSTLPAQELINPENGCIRVRPTMQLAHEKLSHLFAIGDVADTGMHKAARPGMVQAGVAARNILAMVEGREAREVVKGSPGGIHLTLGLTRSVLFRNPNITAGETEPYAEKKEDGAEDMHIAMAWARRGVKVMKVEDFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G0RXR7</accession>
    <name>G0RXR7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methylthioribose-1-phosphate isomerase</fullName>
            <shortName evidence="6">M1Pi</shortName>
            <shortName evidence="6">MTR-1-P isomerase</shortName>
            <ecNumber evidence="6">5.3.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">S-methyl-5-thioribose-1-phosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MRI1</name>
        <name evidence="7" type="ORF">CTHT_0000140</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-(methylsulfanyl)-alpha-D-ribose 1-phosphate = 5-(methylsulfanyl)-D-ribulose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19989"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="EC" id="5.3.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.23" evidence="6"/>
    <dbReference type="EMBL" id="GL988030">
        <property type="protein sequence ID" value="EGS24083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690569.1">
        <property type="nucleotide sequence ID" value="XM_006690506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RXR7"/>
    <dbReference type="STRING" id="759272.G0RXR7"/>
    <dbReference type="GeneID" id="18254052"/>
    <dbReference type="KEGG" id="cthr:CTHT_0000140"/>
    <dbReference type="eggNOG" id="KOG1468">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016218_1_3_1"/>
    <dbReference type="OMA" id="CETRPLN"/>
    <dbReference type="OrthoDB" id="2461at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.420:FF:000003">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000003">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="entry name" value="translation initiation factor eif-2b, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01678">
        <property type="entry name" value="Salvage_MtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005251">
        <property type="entry name" value="IF-M1Pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004326">
        <property type="entry name" value="PRK05720.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00512">
        <property type="entry name" value="salvage_mtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475:SF1">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS24083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="382" mass="41699" checksum="9BBF33D9ED83C20E" modified="2011-10-19" version="1">MATLEAVKYSRGKLLVLDQLRLPHEHHYDEVNTAEQAFDCIRAMRVRGAPAIAIVAALALAVELHHGACKATTVQDTISYIDGRLDYLKESRPTAVDLFNAIAKLKAAIRVSPSSPTDIISTFIATAEEILRLDLSNNTSIGAHGADWLTQQYNLSSSNKISVLTHCNTGSLATSGHGTALGIIRTLHSRQLLYHAYCTETRPYNQGSRLTAFELVFEGIPSTLITDSMAAALFKLRRESDKIGAVIVGADRVARNGDTANKIGTYALAVLAKHHGVKFIVAAPTTSIDLETESGDGIKIEERKKEELTQISGAVIREDGSVDTSRTVRVATADQRIDVWNPAFDVTPAELIDAIVTERGTVVKGPNGRFDFKEVLPERWRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G0RXT0</accession>
    <name>G0RXT0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase family 31 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0000270</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988030">
        <property type="protein sequence ID" value="EGS24096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690582.1">
        <property type="nucleotide sequence ID" value="XM_006690519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RXT0"/>
    <dbReference type="STRING" id="759272.G0RXT0"/>
    <dbReference type="GeneID" id="18254065"/>
    <dbReference type="KEGG" id="cthr:CTHT_0000270"/>
    <dbReference type="eggNOG" id="KOG2246">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024640_2_0_1"/>
    <dbReference type="OrthoDB" id="414175at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006740">
        <property type="entry name" value="DUF604"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10811">
        <property type="entry name" value="FRINGE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04646">
        <property type="entry name" value="DUF604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408602" description="Glycosyltransferase family 31 protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS24096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="611" mass="67943" checksum="93FBFB4E773C3671" modified="2011-10-19" version="1">MPSKLSSRSSLIILVALLLAVLFLTASRLHNASPAFSHLVEDWSYRPSASSSEVTPTKDAVHDGIPPQGPLHAPTGSKPVKINDVSPPNPAIQAFCSHDLDLLRQKDLGLTQKVLYTRRCVRPVYKSTTDPSVLANVTDDPFFTSTVTIDLQSSDSCVAGTKPPPCEPLTLHVPPAYPDPTDSHYRHFLFGVASTYDRVESSLPVFKHWMANTGARIVFVITDARRNDRPLDLDALRKKYRAEGMRAEVISPQWTSPLPRKNNLHPNPDDPMPTEQLHFLMIRDMLHFVAHPSVEDTLGEDDEIFPEVHWLGILDDDTFFPHLHPVSKALSKYNHSQPLYLGALSDNFHALQDWGYIAFGGAGVFLSVPLAQQLNPLLETCLAETDISSGDGMLAACVYAKTTAKLTLIPGLWQHDIRGDPAGVFEGGRGRPMLSLHHWKSWYHAPVREMAGVVKVCGECFLQRWRFWPPMSVVDDDGSLRGREAAGQGTPDAVVLTNGWSVSVYQRGSLAEGFDLDWTEATFDSAPGDGRYDFTYGPFRRRMEEHEKKSYRLALVDGPKEVEPEGTETASKGGWGSSKKAEGKRKFRQIYVHKAKEEGGMDEVVELMWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0RXU7</accession>
    <name>G0RXU7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0000440</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988030">
        <property type="protein sequence ID" value="EGS24113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690599.1">
        <property type="nucleotide sequence ID" value="XM_006690536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RXU7"/>
    <dbReference type="STRING" id="759272.G0RXU7"/>
    <dbReference type="GeneID" id="18254082"/>
    <dbReference type="KEGG" id="cthr:CTHT_0000440"/>
    <dbReference type="eggNOG" id="ENOG502TEVA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_679720_0_0_1"/>
    <dbReference type="OrthoDB" id="5213764at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS24113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="405" mass="44808" checksum="50CBFA177AD19B3C" modified="2011-10-19" version="1">MGRIAGIDRRYCFGTTSFFDITGRMIAACLLLSPTYGLPSSAAAAVHDPVTYLQPAEQLKKALNELSRVSKPIIKRYENDHIVLADCRDASEVLSSQMAYYEDGLEGTPKDVAIVDTPYDQTRVWVNANTSAQFSTTGVWFNASIGPKVPEGQFAGVGRNDYENFTCWQEYRANLYVYDGTQCHGVYDCRHQAIPENVTWVPPGVHRKEDKMSKGTIIGIAVGVAGGVLFLIAAVLVFWYYRRLHKGKEASSQDEAQNAVDDTQGDKGAPVLMDTNAICEIDGRRYRVEMSDETGKVELDAHEKAELPGDFTFIRPAVADGEDSGGKGNKLGKTESAKLQQEISASQGEPATPLTASTPLDEPPSYQQTQEEHLKRQWEQEELAQQEQALLHKSQQLDPHRQTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0RXZ1</accession>
    <name>G0RXZ1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative chromatin binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0004800</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691019.1">
        <property type="nucleotide sequence ID" value="XM_006690956.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0RXZ1"/>
    <dbReference type="GeneID" id="18254518"/>
    <dbReference type="KEGG" id="cthr:CTHT_0004800"/>
    <dbReference type="eggNOG" id="ENOG502STGS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002208_0_0_1"/>
    <dbReference type="OMA" id="IIWDPLA"/>
    <dbReference type="OrthoDB" id="436852at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18966">
        <property type="entry name" value="chromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="5">
        <location>
            <begin position="40"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="92"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="616"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1263"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1444"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="202"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="632"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1278"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1304"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1329"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1444"/>
            <end position="1454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS23777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1466" mass="167189" checksum="3F91A3562344E952" modified="2011-10-19" version="1">MFKLEPRTSFEVPPDQPDVDDDDISLTSTIPEEHDPDEEFEVEEILAEDKSPNGKMYYLIKWAGFPLHESTWEPEDNIKGNELLPMWEEEKARQRAGLSKPFELSDFHEAQARVKREHQERHRRRNAKRKRLGLPLTPPFDDEDITDNEAQEISEIEDLSPKSVPLHKTRPPIPAKRTKASSGSETVRRSSASSLSGLSKAQRNESRRSSIGDDKSSSRSSSSTKRDQAVPPPGVSRKPSKTPGESTIKAAISSTSVPKQPDITGAKSKLKAKRSAVQPAGNIFVSGKIINPRPNLTNAMSDPTKEPKLFHKHHYRRLAEKRSRDTEDIAPADPSKLPVPLFNLSKGPDAIRRSSASNGKPDRPGLFVSQSDSASPVTPVNPSLTTTVPSAAPPALRTFTTDEPAKKKRKSVRFLDDDVPPAQEPEPMDIDSPGNRQNSIVDPPEPGVQPARPCLDFDSWKRPPETQSTQKRLIAGKISLQATFNNLPKEELPQHEWLNDFLSKETIEFTHSCFVNAVATQLSWLLREPLACGTIVSSDHQILDQVAEYLTAGLLGLYCGKTEYNIIVYPAKCDDWKTLPLGQEPENTNDTAVLRFFIFVATQDCRLMLPPLPDELPVPSTPAAETEQAEDTQEKKKPEKNDRTKSEQGVVPTARTLLMKRFFGLEYEKLFPADKFRLKPDTFFLAVPRSRQEPMKMIYHWLRDCNPECQVYNSLSPGSWQAFRARVEANAGVIIIHESLAWSLRRFPDLSKFLRGKKDEYWCLTEPMHRLPMYPSIAPSENARPGEMRLIRLFPYRTVIMLTPSFMVTAPRQTFELLSWFTAFAWGFYYRLIVPYNFHEYLFEVAEDKKGQREFALKRYRGCIPPDIEAAIDTEEDSKYRMAVANIASELNFVRGACGGLHAHRENECTVIYADQSIDPNDEQSLVNWLGWWSILRADQFRKFYVVGSSHKKGDRRAELRIRIPKYSKVTLNDPDAVMDIIQEMNNQADDEEDGKMERSQQQRQLELVQQHQRGWSFQSDLIPIENFARISDYLDHLEYSLDLPKERRRWVLYKFPVSWYDIQMADYYDDTQLLYNRINEWFNFAWPFGGPSKKSPYNTYVGFFYTTDDDWDPDNPPDGKAPKPVKRYPWLAIYRPVNPHIKPFQRTEVIIWDARAKTKFRGKERIPEKELVWMQRAMIQHIREYGDQTNHGTYLDRGWLGGFEWPADCDSPYLFDVTLRFLERMLVDLKTFLPAPEHAMISRGYRPINFDNIQDTTAASLSSANRLPLDRPDRLNGDASAAIDIDSSDDNGNSRSATFVPSEDSDDEDADDDPENTRIIFHPPRATRSFNPPATGQSSSCTETATAPTSASLYLRSKCRNRLYEEARLARLQRKARLREGRHEEDDDGKMLYSFLPTLEWYKDWQEEGRDFKHLNVDEWERIFPLLKISSGLESGATLTAGGVSAGSVAGTVPGNAAGSRAVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G0RY44</accession>
    <name>G0RY44_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0005350</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the UPL family. TOM1/PTR1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="4"/>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691072.1">
        <property type="nucleotide sequence ID" value="XM_006691009.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0RY44"/>
    <dbReference type="GeneID" id="18254573"/>
    <dbReference type="KEGG" id="cthr:CTHT_0005350"/>
    <dbReference type="eggNOG" id="KOG0939">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000215_0_1_1"/>
    <dbReference type="OMA" id="ADEMKYG"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000004">
        <property type="entry name" value="E3 ubiquitin-protein ligase HUWE1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000003">
        <property type="entry name" value="E3 ubiquitin-protein ligase UPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010309">
        <property type="entry name" value="E3_Ub_ligase_DUF908"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010314">
        <property type="entry name" value="E3_Ub_ligase_DUF913"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF67">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HUWE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06012">
        <property type="entry name" value="DUF908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06025">
        <property type="entry name" value="DUF913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14377">
        <property type="entry name" value="UBM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="13">
        <location>
            <begin position="3698"/>
            <end position="4034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="220"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="290"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="741"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1173"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1531"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1588"/>
            <end position="1650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1980"/>
            <end position="2038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2066"/>
            <end position="2107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2358"/>
            <end position="2407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2424"/>
            <end position="2554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2568"/>
            <end position="2598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2829"/>
            <end position="2924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="3002"/>
            <end position="3029"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="3083"/>
            <end position="3103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="3179"/>
            <end position="3211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="3317"/>
            <end position="3387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="3499"/>
            <end position="3520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="290"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="756"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1217"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1588"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1630"/>
            <end position="1644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="2013"/>
            <end position="2038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="2066"/>
            <end position="2078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="2097"/>
            <end position="2107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="2371"/>
            <end position="2380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="2398"/>
            <end position="2407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="2424"/>
            <end position="2447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="2464"/>
            <end position="2518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="2525"/>
            <end position="2543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="2544"/>
            <end position="2554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="2568"/>
            <end position="2577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="2583"/>
            <end position="2598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="2829"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="2909"/>
            <end position="2920"/>
        </location>
    </feature>
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        <location>
            <begin position="3002"/>
            <end position="3018"/>
        </location>
    </feature>
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        <location>
            <begin position="3083"/>
            <end position="3097"/>
        </location>
    </feature>
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        <location>
            <begin position="3192"/>
            <end position="3211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="3317"/>
            <end position="3336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="3343"/>
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            <begin position="3367"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
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            <begin position="3503"/>
            <end position="3514"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="11">
        <location>
            <position position="4001"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS23830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="4034" mass="450748" checksum="2D673082FCCD6D1F" modified="2011-10-19" version="1">MGKITKTMQPRHKETLSPWLKDYVQTAASLPLPLIPQKLEEFPTRWPFPRGDLYHWIPLLNRFDSILEAFCATYELNKGFQMRDFGCDLLMNKGAPVEYCDQQGWSKERLAQLGYGEDGDCQLIVSILNFTRVLLQHCGNRSIYASSMHLNDLLNTTYLSVVYATLEVGLELAQRYQASIKRVAQPTRQVSSALLANHYNIDLDRVQVLSQPFVKTPVAPVAPRFPVDGPPQTPASASKGKEKTSGSHKPPAPVYANDLTALVAPGSPDDGRWNGWGDIKIVYYPKTDPSGTSAADASAENRPSPSTNVPATPTPLRRSSTGPSQPSQHTPRPSRTSGVDESPGSRNQEANVDEHGPKTIEIRQATVQSSSIYELLRLCPVDMPKVSRYEFLNRLRICKALFGSTEDRQLAVAVRLLAITNLAYIHSENTFAEKVLKQDNDEPRRYQLVYQLAELIHPSVAGAPETPLWLQAIAFAALEAISVVPAKYADVLSALNANVNHGVLLYVIRKAVASMREDPVEADEGKVTDADHWRGSLFALTLHMAMSSRIGQEMASAGLLDILVEILNIRSKTATRNYSMVLAFLDTLVYTYQGAFSNFSSAGGLDAISRLIVDTVAQSRDLVAQGLGTKPEFHAQLVDYEIPFYHQQTLKWLLKFIHHIMTNAFSFGANTDRLLRNLVDNSSLLRSLRVIIENTRVFGSVVWTNAASLLSDFLNNDPTSFAAISESGLIQSFLSTLTGREVTLPKPPGSPKPEQEGEDVSSPDYSDDSITFEPDTRPHPPTAEMLEEPRENLAQGILASSDAINVIPPILNSISLNNQGMKMVVASNALESYLEIFESPDHVQVMSLVDPDLAGVVGSSFDELARHHPKLRPSISNAVIDMVARVLHIAKTKAAAAGWGAKLLVVDPTGQKVTADESLLANLEGVTKGKGKATPDDMDVDMVDVIPPGPSTPTGGDAEGESGLEKPIGAHHEITPYILALAQFLGSIVTNSSLRSTFVQDGGIELLLELSEAPSLPEDFDNTQASRTLSQVIAQLIESSPVLGIPSLLNRIHAAIDDLQPLVSKERSQSFFAPFIVPGSSLVNTQGEWDATQVRKVASGTRVVKALVKLQTLVKTLYQSFPYASRQGMVTMPAVNAYDLFRSLIRRLGPLLHGIITEEMAIAALVPQHWTGTKPVTQDGTELPAPPVASSGIGDESKDDSNITDTISNKKPAAATEPKKPTQEERSTVQFQNYFVIHQLLHSLTPSTLPFFQTIGKTLLLKRATDRDNHLRSYHLSIADALAETVLEQLKTSQDQLTARDLHYWIVMFHTLREMLIEPPRHGDRSVNAQLILPVLVALKERGGLEMLNAMLQKFSDEIRNGNPDGDDAHKVRLATVGMKKILEIYHLIANGKNVNDSLSQTSLYPRNMHRDRDYGHQLVVELRYAILPVVRKLWESDIAEKAPTPVLSKIIDILKTIAAGDQELSAWRKSDKISPQPIFKNREPLRFPWATHSNTIKSLTEHFDEDLVREAVYRANGKVDDASEYCRAHSKGIAGKRNPIPKEDEYQRTSSPKPQQPRKHLDAEEEQQLRATADAMQFLRDMGEHVFGESSDHSSDESHDHSSHDIGAEDSPIPVQEASSRATTKMETDSGPSSAAAADSRPAWVTKEDLDEERTKLQKDLIERCLDVVRAHPDSVFEISDLVDITLLRSDNEEKRTEVGEILANALMSFAMNDDVERRENGQGISAYAHLLSLLLQNRPFFESTLPTLKQNIEDYLGFLKVSPASSNEELPSWLPYILLIFEILLSDDQQPVEVHWKPPVTDDEPLEQPVWKVKEPSVSDEHRSSLLRAILDILPRVGKEESLAISVLRILVILTRDHAMAKIVGEKRNLQRLFVMAKQSCSGGSARLNQTHISDNIMIILRHIVEDEDVVRQIMQTEIRQFLSSAQRNPRSYDVYSYLRHLSHVALRSPKLFVEVTNDLVKLSRWVSLDTGISRGHHSLALKEQPAENPEPPKDGSVEPAVQATEDLTIEDVKPTTESADKEMPDAPKGPFEIKRPVLENPDGVIHFLLCELLNYREVDDKELPVPTSKDQRAEGEPSSAGGDTVSTSSDDQPSESKEKDKKSLKPVFKAEEHPIFVYRCFLLNCLAELLQNYNRCKVEFINFKRSAPMQTNTPIKPRSSILNYLLNDLLCLGPAGIPLDSTAIKKKAATSNHAQAVLCALVARTPEKPIDRSRDHYEYDDDPDLLFVRRFVLDTILRAYKEASQPGEPIEIRYGKMMCAAELMSLMIGEKDRDAQPRDNRGTDPVIVRSQMQLKRLMYEKGYIAALTSSIADIDLTFPNVKRTIKYILRVLRSLTKTAYHLSQLDIIPATVTDQPEDDFLSSSSLSDLDDDREETPDLYRNSTLGMLEPGREEDFSDEDEDDEDAMYDDEAYDDELDYGDEMSQDEEENPSDDDEEELDEMGEIEGLPGDPGVVEVIMGENDDDVDEDMEEEDEEPSEEDEGDEDDEMGSDDMEDVEEQVEIVDEEGNPIDDDGASGWESATDEEGEEGDEDLEYEGEGQDMHDAVHGHGMDRIPDILRTVVDGEDLDGEDIDDHYIDDGGEDDEEEDEDDMEDDEVYYDQGHHHDDYPPPNMPSGLGWDIAVEPGHRVRHGGVRSPFPSGPLIMGHSGHDFRHFFGPSHHSRLIRAPGDDGTNPLLLSSSRHAQDQITRASQQQLIRLGFPPHAFGGPGMDGPLAIINDLMQTIPLSARAGAGIPVSLQLRSEGPSGEIRHLNIPLGNMAQATRDTRREVYQEPHQAVAFIPQSTAERWQEEAKIIFTSNHIDKSRVLANFILGMLMPAAIKEEKEAKAREEEERRKREEERKKREEEERKERERKEAEERAAREKKEAEERERRERERAEAEAARATGQEGAAEEPQAMEGVESTTTQAEQAQPSAPRPRVLTTIRGETVDVTDLGIDPDYLAALPEEFREEVIAQTVSARRSEARQQAADNGENTEVFQEFLDALPAELRMEIEQQERQERRRREREEQRRQAAAAGQSLGPSDMDAASILLTFPPALREQVLLEQGEEILDQLPPDLAAEARALAQRHGLHRAAVQAARAQNAGRQPQATEPKPQRRTIVQMLDKSGIATLLRLMFVAQQGSIRNYLFDVFAHVCENRQNRLEVISTLLQILQDGSTDMDAVERSFGQLSLKAKQPKDNKDTKTPQSLKRTFTSISTSNQTTGSSEVSPLLVVQQCLDLLSELATKNPHIPSLFLTEHESVATTLKRSLSRKGKGKDVSSKAHKFAINSLLGLLDRNLVMESSSVMQLLADLLNKVTYPLQALERRRKEAEEEAKKKAGKANEEERAAAGESAETSNTQASTTTEQPSGQTGEQQAEGVVKDKESEQKQDEKKVRQLIPPTIPDHNLKLVIKIFVARECSSKTFQNTISTIKNLSSIPGAKKVFGEELVVQAKALSENIVQDLDDLLPHILKAESGTEIQGIALAKFSPGASEQNKLLRVLTALDHLFDNKKSNGESSPSSPASPAEGKEIKESTKDELLGSLYHNETFNVMWDKLSACLSAIRQRENMINVATILLPLIESLMVVCKNTVLKETAASQASSQTVLGKNMPLSTPPPEDRMASLFFTFTEEHRRILNELVRQNPKLMSGTFSLLVKNPKVLEFDNKRNYFNRSVHAKSRDQQRQQYPTLQLSVRRDHVFHDSFKSLYFKSGPEMKYGKLNIRFHGEEGVDAGGVTREWFQVLARQMFDPNYALFEPVSADRTTFHPNKLSGINPEHLLFFKFIGRIIGKALYEGRLLDCYFSRAVYKRILGKPVSVKDMESFDPEYYKSLIWMLENDITDVITETFSIEDEEFGVKKVVDLIENGRNIPVTEENKHEYVRLIVEHKLLTSVKEQMEHFLKGFHDIIPADLISIFNEQELELLISGLPDIDIDDWKSNTEYHNYTAASPQIQWFWRAVRSFDKEEQAKLLQFVTGTSKVPLNGFKELEGMNGVNRFNIHRDYGSKDRLPSSHTCFNQLDLPEYDSYETLRSQLLKAITAGSDYFGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0RY54</accession>
    <name>G0RY54_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromosome transmission fidelity protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0005470</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691082.1">
        <property type="nucleotide sequence ID" value="XM_006691019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RY54"/>
    <dbReference type="GeneID" id="18254585"/>
    <dbReference type="KEGG" id="cthr:CTHT_0005470"/>
    <dbReference type="eggNOG" id="ENOG502S29P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053544_0_0_1"/>
    <dbReference type="OrthoDB" id="5329385at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031342">
        <property type="entry name" value="Mug163-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17119">
        <property type="entry name" value="MMU163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="45550" checksum="CD4ACD571007F960" modified="2011-10-19" version="1">MTAPARILRRHLRRDSAWTGPTATAAAAACIVYASPWTLDRRRERVARYISSGSVRKSPAQTPAAKFKQSSTIANNTAAVPAPSGRGDFFPEAWFTYHPRLQTVPPEEAEPDLPPPENRNVKLGKTNFSPPPTPPQQSALRILQDRLPTLLQSPLPQEVLSPHITLHLFPSTHPHLPTVTGRVAYIAALWSSPIAWNRVPLVGNVRLEILSARMVHRPATLSPGMSASAAAGGEGKLADKEEDEIVGPEQLIVKWRTVGGGKGLSGLLAGVTGFVQKKGSSGSRENRPSTDAEAKDQPAEQQSQNADPQSSSSSDPDPPTSSTSLSSSDYEYTGPDTPTSPKEFTGLFIFEFDREGRILHHTIEHMQQGGQWEKGVGAKVVGLTDWLLGGIKGGGTAGGGPVAPAFARVRCNSVGRWLFNRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYE7</accession>
    <name>G0RYE7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Elongin-C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0006430</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691175.1">
        <property type="nucleotide sequence ID" value="XM_006691112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYE7"/>
    <dbReference type="STRING" id="759272.G0RYE7"/>
    <dbReference type="GeneID" id="18254681"/>
    <dbReference type="KEGG" id="cthr:CTHT_0006430"/>
    <dbReference type="eggNOG" id="KOG3473">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130038_3_1_1"/>
    <dbReference type="OrthoDB" id="249087at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000035">
        <property type="entry name" value="Elongin C transcription elongation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039948">
        <property type="entry name" value="ELC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20648">
        <property type="entry name" value="ELONGIN-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS23933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="81" mass="9032" checksum="877C0AF055C09EB7" modified="2011-10-19" version="1">MISPTLKGMLRGPFAEAQSGRCHFPEFSAPIIEKVAEYLHYYHQNKDKENVPDLDIPVELCLVVVQAADYFGLVSKALNAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYF0</accession>
    <name>G0RYF0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prefoldin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0006460</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691178.1">
        <property type="nucleotide sequence ID" value="XM_006691115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYF0"/>
    <dbReference type="STRING" id="759272.G0RYF0"/>
    <dbReference type="GeneID" id="18254684"/>
    <dbReference type="KEGG" id="cthr:CTHT_0006460"/>
    <dbReference type="eggNOG" id="KOG1760">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130032_0_0_1"/>
    <dbReference type="OMA" id="KFGRAIN"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23165">
        <property type="entry name" value="Prefoldin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000005">
        <property type="entry name" value="Prefoldin subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016661">
        <property type="entry name" value="PFDN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100:SF9">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016477">
        <property type="entry name" value="Prefoldin_subunit_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="34"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR016477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS23936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="135" mass="15757" checksum="9079B14CA5D6EE3A" modified="2011-10-19" version="1">MRRGALTKEEEEAIGEDVEVRREDQDKINRFSRLHRHELAIEEELKAKQKEKEELDDITTELELADEDELVPYKVGDAFFHVPLPQAQEMLGISTAKLEEEISELEEKLSNIRDEMSQLKVELYARFGKTINLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYT0</accession>
    <name>G0RYT0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Choline dehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0007780</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS24066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691308.1">
        <property type="nucleotide sequence ID" value="XM_006691245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYT0"/>
    <dbReference type="STRING" id="759272.G0RYT0"/>
    <dbReference type="GeneID" id="18254816"/>
    <dbReference type="KEGG" id="cthr:CTHT_0007780"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_4_1_1"/>
    <dbReference type="OMA" id="KMHPQNT"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF80">
        <property type="entry name" value="GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="339"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS24066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="644" mass="70856" checksum="A46C792A4A19C8F8" modified="2011-10-19" version="1">MVKIAYWLAGLTVLPRWGPGGNYYDYIVIGSGPGGGPLASNLARAGYSVLLVEAGNDQSSNVNSEIVSFFPFAYTDPTLRWDFFVRNFANNTKNLQHNQLIWRRPDGSFYAGRDPPAGSTCLGLYYPRGGTLGGSSAVNAMATMYPSESDWDPSHMREIFARIEKNHYLSAETPGHGFEGYLHTIMSNASSWEGQEDLMKVLGVASEYLGQKQQKILEHLIADPNALIPARDRTEGVFGLAVHADTRWRRFSSRDYVLKTANAVLPDGNKKYRLTVQLNTLATKLLFQDVGHPKKKPKAIGIEYLRGQSLYSADPRWKSSNKGTPGRAYARKEVILAGGTFNSPQLLKLSGIGPAPELARFKIKVVANLPGVGANLQDNYEVPIIGHAARDFQQPAPDLNAPTCNFGAPDDPCVDLWRQGIGPYTAGTTMNSIFRKSAYPAHDERDFFLVGGTFAIRGFWPSFDLRPLDPPKMFALSTVKINPQSRAGTVKLRSTDPRDTPEINFHLFEENDVGAELDLKAELDTVKWARRVFASVPPPLGPLTPVEPPCFETPAPDGSCDDDLDKEWITTQIFGHHPTSTCAIGADSDPLAVLDSKFRVRGVRGLRVVDASAFPRVPGPFPVLPTFMLSEKATESVLEDADRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYZ0</accession>
    <name>G0RYZ0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0001070</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690660.1">
        <property type="nucleotide sequence ID" value="XM_006690597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYZ0"/>
    <dbReference type="STRING" id="759272.G0RYZ0"/>
    <dbReference type="GeneID" id="18254145"/>
    <dbReference type="KEGG" id="cthr:CTHT_0001070"/>
    <dbReference type="eggNOG" id="KOG0527">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_653812_0_0_1"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000041">
        <property type="entry name" value="HMG box family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF161">
        <property type="entry name" value="SEX-DETERMINING REGION Y PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="111"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="111"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="174"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="349"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="174"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="349"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS23418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="420" mass="47416" checksum="28114290C0DE9E3F" modified="2011-10-19" version="1">MATQKMDSAMVKVLGQKYWNHFAIQLGHWNPMKVVIMSEETFSNMSWPVKIELAREMGKYLNEEVMYCQDAENASVWILGPKKVLAPSVLVINSIPIWDPKKKHARVPAKIPRPPNAYILYRRDKHNQVKAEHPGLHNNEISVITGAMWKGESPEVRALYHQKAEELKQQLLDNHPEYRYSPRKPSEIRRRARRAQSSQNTSLKSNLKNMQAAFSPISEITRQIPQASKFLPPFANASWTPYHLLSGSDGPSITEEQNATSAEGTAVMQDDLGQNATSIQELGYAQDVALTQHNAHFPATTVTVTDHELTDESPQDFSGPWSHDDSLSHVNYHFKVDLKMTGHKLQLKGPREQHGKMEEDRTEQTTCCRETGQTDDPYARSEAKLLTFAAATSGRFDTSQQVAVQQRQDIEHSTAAPNQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZ97</accession>
    <name>G0RZ97_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Urease accessory protein ureG-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0002190</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690767.1">
        <property type="nucleotide sequence ID" value="XM_006690704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZ97"/>
    <dbReference type="STRING" id="759272.G0RZ97"/>
    <dbReference type="GeneID" id="18254257"/>
    <dbReference type="KEGG" id="cthr:CTHT_0002190"/>
    <dbReference type="eggNOG" id="ENOG502QR6E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072144_0_0_1"/>
    <dbReference type="OMA" id="KMRGDKP"/>
    <dbReference type="OrthoDB" id="10063137at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05540">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000208">
        <property type="entry name" value="Urease accessory protein UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01389">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004400">
        <property type="entry name" value="UreG"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00101">
        <property type="entry name" value="ureG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715:SF0">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="7">
        <location>
            <begin position="51"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS23525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="269" mass="29001" checksum="EA0FD6AFCED6EA96" modified="2011-10-19" version="1">MTHSHSHDHSHAGHTHDHDHGHTHEILTSPGSYLSREPPLTNRPWGPRSFTIGIGGPVGSGKTALMHALCLALRKTHSLAAVTNDIFTREDAEFLVKNKALPAERIVAIETGGCPHAAVREDISANLAALEDLQARFDTDLLLIESGGDNLAANYSRELADYIIYVIDVSGGDKIPRKGGPGITQSDLLVVNKTDLAEAVGADLEVMERDARKMREGGPTVFAQVKKGVGVEHIVKLILSAWKASGAEEDRRAKGGPRPTEGWEALEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZJ7</accession>
    <name>G0RZJ7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AMP deaminase</fullName>
            <ecNumber evidence="4">3.5.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Myoadenylate deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0003200</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.6" evidence="4"/>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690867.1">
        <property type="nucleotide sequence ID" value="XM_006690804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZJ7"/>
    <dbReference type="STRING" id="759272.G0RZJ7"/>
    <dbReference type="GeneID" id="18254358"/>
    <dbReference type="KEGG" id="cthr:CTHT_0003200"/>
    <dbReference type="eggNOG" id="KOG1096">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003782_0_0_1"/>
    <dbReference type="OrthoDB" id="1723809at2759"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
        <property type="term" value="F:AMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01319">
        <property type="entry name" value="AMPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.20:FF:000001">
        <property type="entry name" value="AMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000214">
        <property type="entry name" value="AMP deaminase Amd1, putative (AFU_orthologue AFUA_8G02860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01429">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359:SF0">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="311"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="962"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1114"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="346"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="976"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="989"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1033"/>
            <end position="1043"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS23625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1142" mass="127713" checksum="9F1EA048DB12B090" modified="2011-10-19" version="1">MAGLAYAHDPLSNSTSPKLPATQMPPGASDDETYERLGRSDTESDEVHDSSDKGEEGDERESGASGESGGGVQGDFRHQRHHTQEQGESDSSADERQDEQQGARASSDEASTEEMEDGMLPRDVPPKTAVYDLLTERQMTEVDAKLFYQRSQAEHLHSGPVSHMSPPGSPPLGGGGFAGVGSQMHSPILTSNLAHSFSNLRLAEQAGDWGGMPEPASKRDPSSYGTESLANSRVNSYAQLNTAVTAGYSTQPDAAAILRQQQQYLNSGAVHGIGSSTYADADPQLDAELRTIFKNVQKVLDIRKKYIALSLQGPNDNPKDQPGWRIYPPPPEPAWPEEQEKYARGASTQAPTSAPNSLQNSMVLDPEKQRSGDQAPPSTSAPASGQVPPETPRKSKAKKRKPGQDIGEDFDMDDLLPLPGSCEEVFRLDENGVYQVYDNEEAMEKERPIVKVPTIKEYYLDLEEILNASSDGPTKSFAFRRLQYLEGKFNLYILLNEYQETADSKRVPHRDFYNVRKVDTHVHHSACMNQKHLLRFIKSKMKKSPDEIVLYRDGKYLTLKEVFESINLTAYDLSIDTLDMHAHKDSFHRFDKFNLKYNPVGESRLRTIFLKTDNLIKGRYLAEITKEVIADLESSKYQMVEWRISIYGKSPDEWDKLAAWVVDNKLFSHNVRWLIQIPRLYDVYKSSGLMDSFEQIVRNVFQPLFEVTKDPTSHPKLHVFLQRVVGIDSVDDESKVERRLFKKFPVPRVWDSKQNPPYTYWIYYLYANLVSLNHWRKRRGFNTFVLRPHCGEAGDSEHLAVAAQCCHSISHGLLLRKVPLLQYIFYLEQIGIAMSPLSNNALFLAYERNPFLQYFKRGLNVSLSTDDPLQFAFTKEPLMEEYAVAAQIYKLSSVDMCELAKNSVKQSGYEFAIKQQWLGKDFYLPGARGNSMIKTNVPDRREEFRYHTLLEERRLVEMYAHKSDEPTTGPSLPAKSPELSSSHLSGSPMTTEPKQQPHLQQRNISHISLPQAARMGSPSPGPAPGSAPASRSVSWANVGTQTDSPHLHSSMSQSQLLGAAGAGGMTPMMMMPSPMIPVGEPSAIGEQMSMSGSGHWTPAAADSARELHLSGVEPRYFPGMVARSQKRRGSGRQSSMHESDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2023-02-22" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZQ4</accession>
    <name>G0RZQ4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0003790</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690924.1">
        <property type="nucleotide sequence ID" value="XM_006690861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZQ4"/>
    <dbReference type="GeneID" id="18254417"/>
    <dbReference type="KEGG" id="cthr:CTHT_0003790"/>
    <dbReference type="HOGENOM" id="CLU_949957_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS23682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="293" mass="32553" checksum="4241975902B2A74B" modified="2011-10-19" version="1">MKTWRKFVEAVDWVSIRVELSAEMEEVKPVVMGDNGNMFEGARELEDTVKNFDSADELEIAEVDDSTSDVKEFIDEAIIELMRIEDLVEDVYDVLEEDKELVDDCDEVAGNDWVNTEVSVEVSVKVCDSLDVLPTEMTVIVDDIEDVAEKIWDVEDDKVSVDVIDTTDELLVVSLEVDQTKELELLEWEEGSSVELVTIDGTKVGVKRFEGDTLDVKDHVVEIVVDVLDGTRDVDELVALNGLVVVELILCKEVIGIDVEGSGTEEIDGGGVMDTERVFVAEPECLSCKIDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZS7</accession>
    <name>G0RZS7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine-threonine kinase receptor-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0004040</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690947.1">
        <property type="nucleotide sequence ID" value="XM_006690884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZS7"/>
    <dbReference type="STRING" id="759272.G0RZS7"/>
    <dbReference type="GeneID" id="18254442"/>
    <dbReference type="KEGG" id="cthr:CTHT_0004040"/>
    <dbReference type="eggNOG" id="KOG0278">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_6_1"/>
    <dbReference type="OMA" id="DGFYGLW"/>
    <dbReference type="OrthoDB" id="408728at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF13">
        <property type="entry name" value="SERINE-THREONINE KINASE RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="60"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="303"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS23705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="354" mass="38987" checksum="CC76CCD16C9BB4D0" modified="2011-10-19" version="1">MGETAPRQYVPLTCHGHSRPVPHLSFSPLEKDDVYYMISACKDGNPMLRDGQTGDWIGTFLGHKGAVWQARLSPDASTAATASADFTAKIWDTHTGELLFILQHEHIVRAVAYPFDRSDLIATGGFEKKLRIFDLQEARKQGQPTDAQGIAQPITIEPSKAFEIGEGVHKEAIKFIVWARDPSIIVTASGDTLRWFDIPKRECIREAKLDGEIKSCELVSLAPSYTSQTDIGGGLPVLAVAAGKTAYFWGGMRADEELKQMKLSHGIASVGVDLKNRKIVVGEEPGTWARVYDWEDGKELDVHKGHHGPIWSIAFSPDGNLYATGSEDGTIKMWKNCEGYYGLWRGGVSNNNTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZU9</accession>
    <name>G0RZU9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Homoserine O-acetyltransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0004280</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690969.1">
        <property type="nucleotide sequence ID" value="XM_006690906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZU9"/>
    <dbReference type="STRING" id="759272.G0RZU9"/>
    <dbReference type="GeneID" id="18254466"/>
    <dbReference type="KEGG" id="cthr:CTHT_0004280"/>
    <dbReference type="eggNOG" id="ENOG502QR3J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028760_7_0_1"/>
    <dbReference type="OMA" id="HPILVMG"/>
    <dbReference type="OrthoDB" id="444135at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009092">
        <property type="term" value="P:homoserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001209">
        <property type="entry name" value="PRK00175.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF16">
        <property type="entry name" value="SERINE O-SUCCINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="193"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="124"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="48"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS23727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="592" mass="64878" checksum="A59D493801167C71" modified="2011-10-19" version="1">MKSTTASLRRASRGLRFTHTPSSSSSCCSSLRPSICSSHVVGSAVPVPGTRRSTSSSAADAVAAPTSSPSPTSTRPQTSSSSLQQPPTRRHLHGQFIRRSGVPSNPAMKFPCVDALESRSATLQRQAEAAAAQRRSLEDTEGDTGGPEPSYTVGPTQVFHSYEPFLLDHGGLLHEFDIAYETWGRMNADKSNVILLHTGLSASSHAHSTPENPQPGWWEKFIGPGKALDTDKYFIICTNVLGGCYGSTGPSSIDPLDGKRYATRFPILTIQDMVRAQFRLLDHLGVRKLHASVGSSMGGMQSLAAGVEFPDRVGRVVTISACARSHPYSIAMRYVQRRAILNDPNWNRGFYYGRVPPHTGMKLAREIATITYRSGPEWEQRFGRRRADSAKPPALCPDFLVETYLDHAGEKFCLTYDPNSLIYVSKAMDLFDLGLENQRRTARRREEALVRRLAEAADPSAQDEDGTCILTPPDLSNQDQHGQNQAHNEIIQTLTDPTPVQRRAAAEAYNPPADLVAGLAPLRNHPTLVMGVASDILFPAWQQREIAEALRQAGNTQVEHVELSEEQSLFGHDTFLLDVENVGGAVRRFLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZV7</accession>
    <name>G0RZV7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Specific protease-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0004370</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2018" name="J. Biol. Chem." volume="293" first="13224" last="13233">
            <title>Discovery and engineering of enhanced SUMO protease enzymes.</title>
            <authorList>
                <person name="Lau Y.K."/>
                <person name="Baytshtok V."/>
                <person name="Howard T.A."/>
                <person name="Fiala B.M."/>
                <person name="Johnson J.M."/>
                <person name="Carter L.P."/>
                <person name="Baker D."/>
                <person name="Lima C.D."/>
                <person name="Bahl C.D."/>
            </authorList>
            <dbReference type="PubMed" id="29976752"/>
            <dbReference type="DOI" id="10.1074/jbc.ra118.004146"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.44 ANGSTROMS) OF 935-1186</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690977.1">
        <property type="nucleotide sequence ID" value="XM_006690914.1"/>
    </dbReference>
    <dbReference type="PDB" id="6DG4">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.44 A"/>
        <property type="chains" value="A=935-1186"/>
    </dbReference>
    <dbReference type="PDBsum" id="6DG4"/>
    <dbReference type="AlphaFoldDB" id="G0RZV7"/>
    <dbReference type="SMR" id="G0RZV7"/>
    <dbReference type="STRING" id="759272.G0RZV7"/>
    <dbReference type="GeneID" id="18254475"/>
    <dbReference type="KEGG" id="cthr:CTHT_0004370"/>
    <dbReference type="eggNOG" id="KOG0778">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_272361_0_0_1"/>
    <dbReference type="OMA" id="IDYEAPR"/>
    <dbReference type="OrthoDB" id="1939479at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016929">
        <property type="term" value="F:deSUMOylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606:SF141">
        <property type="entry name" value="GH15225P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606">
        <property type="entry name" value="SENTRIN/SUMO-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="976"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="274"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="910"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="141"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="910"/>
            <end position="932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS23735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="6DG4"/>
        </source>
    </evidence>
    <sequence length="1186" mass="134509" checksum="39AFCB8A15342EA2" modified="2011-10-19" version="1">MPSQASSTPRTTRNSRGLRAGPYPAPSLSPSSRLSTAGPVPVPSTPTPRSRRSSRPRASTPSGRPTRAGASSSCLGLKAVEEEPAASPAAPITPSPPSSPSSPASSLRHKPVYPRTPSKPRANFRRRYVYAEPSIPPKPRSPGDETHRFTSRRDEEGEDKFARELWIAIRNDHYMRGCWCGSPKIYNSKEEAEAGAGHLRFYIAGNEKKKNLRVLQKKYDFIWHCMCSAGKEYLPAYKALLNSNGKRPAEDDEFELLAQNEDSGDKTKTIKRVVTKIPDATTDDDSTPEDEEKPAVPEQATDTPAQGFWDQARSLFNRAIESMTTPITSLFNKIRKHISISLMDYDTLDIRSKDAANNIVVKRVRRVQPLINVNKEQLPGREIEDDLYAFEDLEWAESATSAIGFDQLRQIVITFTSQKSSLERGMIAMGESIEDIKANAPSECDKTASVCLHAWIEQEHGSLADLPFAEREEKFKNYLDDYHGQLGKTIEFIKQIYDSNLLAALRAKHPKPIYPLKLGHVFFRDGARDVAEFLCFFCSLEALFDIPAFMMEALYKMVVDANAIHKQELPPSFIKLRREPTADMPGYFPDDKASPLEEIPAHQCNVVSRYDYLHPSQEAIESRADPDERKLVRKPKGILKPSKQWPTPASPAKYVPTPQKPRKLVFLNPVSTFAPPKNIPTRVMRPHDEEEINYWKMKTELIGDEYTKKKYESKLSLTLNWEKIRARINRDRFAPENVQEDDKDMGLSHYANKYGNFLDELHDDMVKREQKEKEEKLNRDKPGEVKEIIEPIPTQVPRPFTSPEFRRITAHCREGYTGTASPLWKVDVSKVIERKPKAEEKPEPKNLDEFFAQDDDDLEISMLMLSHIQINDAVIKDAQRKKQEEKRRKEEEALLAEERRLEALIREREEEERLKREAEEKAQRERKAEEAAARSGLRPPARQLITPLSEEWRSRVEAARNANPATELAKTLEGQPLVRRDFEEKLLPATAWLNDNVIIGAIFYIADYVNTKKGAPNQEPKCTAFTSFFWPRLLSHGPGGCGRLLRRANVRKANFLDIDTILIPICESSHWTLAVIRPGRRTVSHLDSMAAGRGSERVKAKLLELVKFVLEDQFVEAEWQAVDFQAPRQTNGWDCGVFTITNAICLALGVDPAQAYTEAQLPLQRQRIAAVLLNGGFKGDFTLDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZW6</accession>
    <name>G0RZW6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-1,2-galactosyltransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0007880</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691318.1">
        <property type="nucleotide sequence ID" value="XM_006691255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZW6"/>
    <dbReference type="STRING" id="759272.G0RZW6"/>
    <dbReference type="GeneID" id="18254826"/>
    <dbReference type="KEGG" id="cthr:CTHT_0007880"/>
    <dbReference type="eggNOG" id="KOG4748">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021434_2_1_1"/>
    <dbReference type="OMA" id="DQDAYIM"/>
    <dbReference type="OrthoDB" id="205108at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000149">
        <property type="entry name" value="Alpha-1,6-mannosyltransferase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF10">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05637">
        <property type="entry name" value="Glyco_transf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS23127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="330" mass="37253" checksum="FAB7ED759213A5F1" modified="2011-10-19" version="1">MHFALPPRKSSNPPPYRPRSSRGGILQFIPGRLRRVRPRAMVLAGVLFLITLFYLLSGSGGSGSSRSSSGKRIPKLAPTGHPPVVLVTVLDDRKFSKGYLEMVKENRERYAEMHGYKTFFPSVTDYDLGSAPSSWALVPAIRHALTTFPNCRFVWYLDQTALIMNPKLKLDEHILASGKLDALMKKDHPVVPPDSIIKTFSHLRAQDVDLVVTQDNETLSPGSIVVRNGDWARFFLDTWFDPIYRTYNFQKAETHALEHIVQWHPTILARMAIVDQRVMGSYAERAPGLEEWREGELVVRFGPCKGESGPQTCEQTAQPYISMWKQAFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZZ2</accession>
    <name>G0RZZ2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NADH-ubiquinone oxidoreductase 9.5 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0008140</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="4 5 6" key="2">
        <citation type="journal article" date="2022" name="Sci. Adv." volume="8" first="eadc9952" last="eadc9952">
            <title>Conformational changes in mitochondrial complex I of the thermophilic eukaryote &lt;i&gt;Chaetomium thermophilum&lt;/i&gt;.</title>
            <authorList>
                <person name="Laube E."/>
                <person name="Meier-Credo J."/>
                <person name="Langer J.D."/>
                <person name="Kuhlbrandt W."/>
            </authorList>
            <dbReference type="PubMed" id="36427319"/>
            <dbReference type="DOI" id="10.1126/sciadv.adc9952"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.44 ANGSTROMS)</scope>
    </reference>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691344.1">
        <property type="nucleotide sequence ID" value="XM_006691281.1"/>
    </dbReference>
    <dbReference type="PDB" id="7ZM7">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.77 A"/>
        <property type="chains" value="g=1-82"/>
    </dbReference>
    <dbReference type="PDB" id="7ZM8">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.76 A"/>
        <property type="chains" value="g=1-82"/>
    </dbReference>
    <dbReference type="PDB" id="7ZMB">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.75 A"/>
        <property type="chains" value="g=1-82"/>
    </dbReference>
    <dbReference type="PDB" id="7ZME">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.83 A"/>
        <property type="chains" value="g=1-82"/>
    </dbReference>
    <dbReference type="PDB" id="7ZMG">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.44 A"/>
        <property type="chains" value="g=1-82"/>
    </dbReference>
    <dbReference type="PDB" id="7ZMH">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.47 A"/>
        <property type="chains" value="g=1-82"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZZ2"/>
    <dbReference type="EMDB" id="EMD-14791"/>
    <dbReference type="EMDB" id="EMD-14792"/>
    <dbReference type="EMDB" id="EMD-14794"/>
    <dbReference type="EMDB" id="EMD-14796"/>
    <dbReference type="EMDB" id="EMD-14797"/>
    <dbReference type="EMDB" id="EMD-14798"/>
    <dbReference type="SMR" id="G0RZZ2"/>
    <dbReference type="STRING" id="759272.G0RZZ2"/>
    <dbReference type="GeneID" id="18254852"/>
    <dbReference type="KEGG" id="cthr:CTHT_0008140"/>
    <dbReference type="eggNOG" id="ENOG502S74C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166990_0_1_1"/>
    <dbReference type="OMA" id="EKPAIFW"/>
    <dbReference type="OrthoDB" id="2093409at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22903">
        <property type="entry name" value="NI9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039961">
        <property type="entry name" value="Nuo9.5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4 5 6" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="7ZM7"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="7ZM8"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="7ZMB"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="9066" checksum="2D09E90FD83CD487" modified="2011-10-19" version="1">MSATTPRFWSTPLKYCRWAARERPALFFSVVIGALGPVTLATVPPLRRLIGDVDAAPIPLTYPIPPGPRKQLKGYDDDTEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-12-14" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0H9</accession>
    <name>G0S0H9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0010080</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691531.1">
        <property type="nucleotide sequence ID" value="XM_006691468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0H9"/>
    <dbReference type="GeneID" id="18255046"/>
    <dbReference type="KEGG" id="cthr:CTHT_0010080"/>
    <dbReference type="HOGENOM" id="CLU_2527258_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS23340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="84" mass="9531" checksum="BC0434A2BC71CE56" modified="2011-10-19" version="1">MMLLMLPQTGELVICQGHADDDGDLDEDGEVTAVEEDEEEVSEALSALLDRDDEVLARRKDVRRLRVEKRDAMAWKRDECILSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0I0</accession>
    <name>G0S0I0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Calcium-channel protein CCH1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CTHT_0010090</name>
    </gene>
    <organism evidence="24">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Voltage-gated, high-affinity calcium channel that functions together with MID1 to mediate calcium entry into cells. Required during conditions of environmental stress.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16 19">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691532.1">
        <property type="nucleotide sequence ID" value="XM_006691469.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S0I0"/>
    <dbReference type="GeneID" id="18255047"/>
    <dbReference type="KEGG" id="cthr:CTHT_0010090"/>
    <dbReference type="eggNOG" id="KOG2301">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000443_0_0_1"/>
    <dbReference type="OMA" id="TLFIAWN"/>
    <dbReference type="OrthoDB" id="416585at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000093">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000118">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000063">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000079">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000098">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002077">
        <property type="entry name" value="VDCCAlpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF7">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00167">
        <property type="entry name" value="CACHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 18 19" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 19" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="5 19" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="9 19" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="394"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="562"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="702"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="838"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="900"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="972"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1201"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1240"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1285"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1331"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1458"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1540"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1572"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1602"/>
            <end position="1622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1658"/>
            <end position="1683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1751"/>
            <end position="1777"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="22">
        <location>
            <begin position="1796"/>
            <end position="1831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="256"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="2002"/>
            <end position="2038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="2082"/>
            <end position="2112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="2135"/>
            <end position="2196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="2217"/>
            <end position="2239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="2007"/>
            <end position="2038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="2094"/>
            <end position="2112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="20">
        <location>
            <begin position="2167"/>
            <end position="2190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="1428"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00057587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00067459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR602077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EGS23341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="2239" mass="251104" checksum="0BF636D5DFA3FCBE" modified="2011-10-19" version="1">MNNNESQGQESRRSPAGQLSPLHSIPLRDFQRTNETDDGTRESGVFGATVQDNASAQTSTRPQAGSYNSRGSPSSAAPSMSANLPGFSSYWEHPYSSLDDGDNNAVSPEERITLQSALPPDIYPQSSYQSRPFATPSNDFYPMPHVYEERADTDSLESDRVPLRPAAQPPGRLEPPEGEATPRTSFQTVPDLGNTPRSGRMLGDDLEQGGGHHLSPTDRRRSRSQSAVGALHRASSMMRAMSQRVVAISGEGELVDQAARRERSRSRSPSPSVDGRRSPGAPGPMLVDTSYPSQLPRIPAERPFEPGLPPPPRPPPRRRGPLSNPLKGNSLGIFPPDNPLRMWLCDLLVNPWTEPIILFLIIAQVVLLTVESVPDVFAEGNQRPARWGGSGIDWALLALFILFTLEIIARIIVSGFIINPVEYMPPGSNRRLRERVAEQYRAIFRPQRQKSVRQQQPEHEFVPPTFARSLTMMHGQESPATLEEELRLHLARRAFLRHSFNRLDFIAVVCYWIAFALSTSGLENRHSIHVFRMLSCLRIIRLLAVTRGNMIILKSLKKAAPLLVRVCFLMGFFWLLFAIIGVQSFKSSLSRQCTWINPEDPTNLSATYTPSMSFCGGHINQTTGENSPWVYAPNDDLSVLVPGAPNAKGYICPRGSICLRQENPYNGTVNFDDIGHSLELVFVIMSANTFSDLMYYTVSSDFLPAALFFGAGIMIMMLWMTNLLISVITSSFQVIREESKKSAFADDEQSIFSTHTEDEKKPQRQSALQRIVKKADWFWIALIIYDLFCQSLRTASMSRGRETFIDTSEVVVTVLLDVEITLRLAANYRSFHRSVRDLFDLFLAVATTVILIPPIRNSGDLYNWLTIFQILRVYRVVLAIPMTRELIQLVLGNVTGIANLMLFVFLMTFLMAIFAAQLFRGQIPYADDEGEFIRIPFNTIYNSFLGMYQVLSSENWTDVLYNITAYTTHFHTAWIGAIFIIGWFILSYFILINMFIAVIQENFDVGEDTKRLEQIKAFLQRRDLGTSSNLALSKVFGFGRSRNRADPLDHTTGVIDKLFKEGYVREFLDEAMGPLQERTAAESKSAQQTAGKSTGNYGPLSKVWQWVTARLASREPNPFYSSNVQFAGPIAALDPGQLARQAMGASAARRRAQREYLMRHPNYNTSLYIFKPRNPIRRFCQKLVGPGRGTERFDGVPPNKYAWYTFSAFIYACIVAMVILACITTPLYQKEYYETHKFRLFNWFVWTDLAFAIVFTIEAAIKIIADGFFWTPNAYFRSTWGVIDGIVLVTLWINVITLFANAGAVSRAVGAFKALRALRLLNVSDSARETFHSLMIVGGWKILSAAFVSISLLIPFAIYGLNLFNGKLVACNDGEGVINLTDCIGEYNSTPFSNDWPVLAPRVAKNPFFNFDDFGSSLFILFQIVSQEGWVDVSFAAQAITGKGLQPESAPPFRNQGAALFFVVFNLLATVFVLTLFISVFMRNYTEQTGVAFLTAEQRSWLELRKLLRQISPSKSSYDDTKNKWKLWCHKRAIEKRGKWYTTITTVLVLHLILLLAEFESEPEWWTNTKEVLFMVFTFIFIVNIVIRIVGLGWTRFRRSSWDLFSLVMVVGTVATSILFWTDRKQTTYIQLHKFFLVSLVLMLIPRNDALDQLFKTAAASLTTIGSLLATWLVFFLVFAIALTQTFSLTRFGAEEDANINFRTVPHALILLFRFSCGEGWNEVMEDFAQAKPPFCVEGETFYDSDCGSTAWARVLFVAWNIISMYIFVNLFISLIYESFSYVYQRTSGLAVVDRDEIRRFKEAWRSVDPSGTGYISKETFPRLLGELSGVFEMRIYDPEDSVPRILEDVRNDGDTATPRHASFGGGSLYPTGIDLDKLNRRLSRLDVAKIRERRRRFNIFYEEVMVSADPERGISFTTVLMILAHYNIINDNKSLRLEEFLRRKLRLQRVEEEVRRRTVLGFFNMLYWSRRFRRHLESKNAGRLLTVPQLDIPEILVDHDEHSSNDMDQNGTGKDQQQHAPSSRPSSIQTSPTQTRSYGQITVAAAESGDGSGSALLSPTAIRAPHRSWTGISGDIASYDPDFGSHPLAGPRSSSLISQQPGLQQQQTRQRGLSQLSAFSFELSAPEEDAFFSDLAGGTSSSRLKGTAGRTGDEIEDIATSPLGPPAGGGVLGSGPAGGSSNGAGGSGDGTSATIDPAVVRDMLDDSVWVESLRRSATMRRSGTRRSRSGWGGSAWGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0I2</accession>
    <name>G0S0I2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0010110</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691534.1">
        <property type="nucleotide sequence ID" value="XM_006691471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0I2"/>
    <dbReference type="STRING" id="759272.G0S0I2"/>
    <dbReference type="GeneID" id="18255049"/>
    <dbReference type="KEGG" id="cthr:CTHT_0010110"/>
    <dbReference type="eggNOG" id="KOG0528">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022445_2_0_1"/>
    <dbReference type="OMA" id="SWPMEPE"/>
    <dbReference type="OrthoDB" id="2307332at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051356">
        <property type="entry name" value="SOX/SOX-like_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789:SF2">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="228"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="228"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="27"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="107"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="291"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS23343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="581" mass="65309" checksum="0CDAB6DA666F998E" modified="2011-10-19" version="1">MNPNTPPSPALTKVEFLPAGFHELLQHNASANFPRELEPNRAHSQPVSRYGTPGPTQPSPKFDASMAYQQRGGSGELVGKQQISGAPRRLTDLQDVYHQQAMYSHDASAYGPIPQPSQPYGTPATSPPTPRASDLVGTRSGNPAHGNFKVLGPKAARIEKATSSKKKTGRIDRPDKSKGVKNMPHLDKPLSELTKDFETPIFDIEAFVHRPIEVRQQEVDSGKNPGKVKRPMNAFMLYRKAMQARAKEWAAQYNHQVISRIAGQSWPMEPEHIREQFKRWAEIERDNHQKAFPNYKFTPSKPQKPAKNEGRYDDSEGSDLDEYDWTGRSASRVRTVTNTPHDEADYLHDQPMYPATHPHPYQLEGLHGLSMMHQNKTGLSFGSPTKSIGASCEHRDLHSGQYYDTHIRTPRRHLPHGLIDEALMRKTPSPSLAFTPNNAGLHQQFDFNQYQTKIEHAAQSQMQRQQTHTQPQHHGAQFETRIDPSLIPGEEGLFETGNFNVANMYDCGLGETAHQAWHNAQLTSGNESDSQFSHAIMGLEETLSLEQHTQFLRGADDWQTEPLPEAAEFDMSWVEPKSEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0K4</accession>
    <name>G0S0K4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxysterol binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0010330</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691556.1">
        <property type="nucleotide sequence ID" value="XM_006691493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0K4"/>
    <dbReference type="STRING" id="759272.G0S0K4"/>
    <dbReference type="GeneID" id="18255071"/>
    <dbReference type="KEGG" id="cthr:CTHT_0010330"/>
    <dbReference type="eggNOG" id="KOG2210">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012334_0_2_1"/>
    <dbReference type="OMA" id="SSYWTEH"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008142">
        <property type="term" value="F:oxysterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120009">
        <property type="term" value="P:intermembrane lipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2720:FF:000003">
        <property type="entry name" value="Oxysterol binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3490:FF:000016">
        <property type="entry name" value="Oxysterol binding protein (Osh5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000010">
        <property type="entry name" value="Oxysterol-binding protein homolog 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF184">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN HOMOLOG 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="423" mass="46574" checksum="B30291FE3C77CCC3" modified="2011-10-19" version="1">MESQTTTTTSAPSVQNTSGGGSWGAFLKSIASFNGDLSSLTAPPFILSPTSLTEFSSYWCEHPSVFVAPSKESDPARRALLVLKWFLTTLKQQYASRSEQYGNEKKPLNPFLGELFLGKWEDEAGVTELISEQVSHHPPATAYNITNLSSGVRLEGYNAQKASFSKTINIKQIGHAVLTVPAPASDRPDKYLITLPSLHIEGLLLGSPFIELDGSSWITSSTGYTARIDYSGRGWISGKKNSFTAILYPTGKEKEVLFSISGQWTKDFEIHSGPFKYNSKDTIVDSWDPLLSPPSKLIVSPIEEQHPLESRRAWAKVAAAITKGDLETVSVEKSKIENAQRQARAKERAEGRTWQRRYFTAQNDVPDPILANLGPIVGLPTHGDSDKTGGLWRFDFEKAEAARNEPRLSQEDAAKIARELLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0T9</accession>
    <name>G0S0T9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutathione S-transferase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0011210</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691641.1">
        <property type="nucleotide sequence ID" value="XM_006691578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0T9"/>
    <dbReference type="STRING" id="759272.G0S0T9"/>
    <dbReference type="GeneID" id="18255159"/>
    <dbReference type="KEGG" id="cthr:CTHT_0011210"/>
    <dbReference type="eggNOG" id="KOG0406">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074611_0_0_1"/>
    <dbReference type="OMA" id="HRCPWAH"/>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF8">
        <property type="entry name" value="S-TRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00590)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="94"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS22649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="25746" checksum="0E888D2C6C50D455" modified="2011-10-19" version="1">MGSQAPEIILYTNHRCPWAHRAHIALAELNLPYKEVIIDLDTPRSPEYLAINPRGLVPALSYNGEIIIESAIVAQFLADQHPSHLVPPSNAPGGALRRARIALFVDAFFSKFNSVLFGLGTAKTEEEKQAVVEKALNGLIKEVEPLLKDAKPFFGGSDKLTLAEVLTGSFVIRLKTFSKAELYPKELYTKITQLAPNFAKWAEAVVAHPSVTKIYNEDEVIAGMKARLAKTRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0U9</accession>
    <name>G0S0U9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GRIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0011310</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691651.1">
        <property type="nucleotide sequence ID" value="XM_006691588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0U9"/>
    <dbReference type="GeneID" id="18255169"/>
    <dbReference type="KEGG" id="cthr:CTHT_0011310"/>
    <dbReference type="eggNOG" id="ENOG502S0A5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002906_0_0_1"/>
    <dbReference type="OMA" id="NIGQDHV"/>
    <dbReference type="OrthoDB" id="1926336at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01465">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRIP" evidence="3">
        <location>
            <begin position="1069"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="16"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="232"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="475"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1040"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="372"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="693"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="506"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1048"/>
            <end position="1066"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS22659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1110" mass="124149" checksum="0816523A56877322" modified="2011-10-19" version="1">MFQRLKGAIDQRIAEEQARQKAALEAQRAAAPRRSRSSSGAGGPSTVRRSRPTAKTGDDGDGPTADPDPAVFEAAFVIDDADDTAASSRASTPLPGDKIPRSGESTANSGKAGPDNPTSGTGSPSNSGNNEQVQAGAEPTAKTASSSTSISELPPEIRARLRKLEKLEKTYPELLRSYRIAHSRATSIEPFEKALRENTPLTSIKDPEALVEYLNQINLKGDMLMEELKRVTTEKDSYKKKAEEAEKELTALREELSSLKAAKSETSSGPDARKDSGAPTDKSETRDSPSRSNEGAGDIFSYESELPQLQAEVQQKTEEIEKLQTEVKNLRDELSLAKEHSASLVESLEHATRELSETRDAVAVKASVETQLEARNAEIAILTERLEKAQSKLKEVEEELSKSKCDAAENIKVTTTQLAAFTSRNQELEREVEQLNQAKSSLDDKIKALIAEIEALKKAKAEDQSRIDELTKQLQVAQEPAATPTSTHIPLGMPIASPASGSGSGGKKKNKKKKKGGAATPAMPAESAPIEASADQKAPPTSDGSALAELQAELTRLQEELAQKDQKIERLAKQRKTEEELREEIENLQENLMMIGQDHVEAKEKIKELEAEKKALKERIAELEKELMSSSAAAKSNADLLKEHETLKQEFDNLKLKSSTLQSDLAAAQQLAQTRYKDLTDLREVLQKVQPELKSLRQDSAALKTTREELNAKNAELRNLEKREKELKAELSRAQRLAADREAEIKTLHEKVAQETNARLRLEEEKRVAGRDLRRAEAEKIEISAREEKATRELQRVQDEANKLRPRIRELEDEVARLKKEQDVLREEVELKINQYTNAQNLLSSMRDQTAELTIQLKESQAQCESLDEELAEARKMLNERTREAETMRRLLADVDERADSKVREMRAKMDAAIEERDRLEDESSALARRKARETEELRQKIKDLEKEIKELSGERDDLERREREWRRRREELESIEERANAEVSEMRTTVNNLRSTLDASELQVREMERKNAELRRALDDYRLRYDKLAKEAKSLQARLAAPSSTISGRSSMESTRSGSGSTAASQTAIGTYPDAMYLKTILLQFLEQKDNRLRAQLVPVLGKLLKFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0S117</accession>
    <name>G0S117_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dioxygenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0012010</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691719.1">
        <property type="nucleotide sequence ID" value="XM_006691656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S117"/>
    <dbReference type="GeneID" id="18255239"/>
    <dbReference type="KEGG" id="cthr:CTHT_0012010"/>
    <dbReference type="eggNOG" id="ENOG502QWDJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046727_2_0_1"/>
    <dbReference type="OMA" id="PFWRANQ"/>
    <dbReference type="OrthoDB" id="5238185at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018576">
        <property type="term" value="F:catechol 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009712">
        <property type="term" value="P:catechol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03461">
        <property type="entry name" value="1_2-HQD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039390">
        <property type="entry name" value="1_2-HQD/HQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007535">
        <property type="entry name" value="Catechol_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050770">
        <property type="entry name" value="Intradiol_RC_Dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711:SF7">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04444">
        <property type="entry name" value="Dioxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catechol dioxygenase N-terminal" evidence="8">
        <location>
            <begin position="37"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="7">
        <location>
            <begin position="114"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS22727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="331" mass="36849" checksum="4BF6F42AEF45B0DB" modified="2011-10-19" version="1">MAEPTSSSGAVNVPPLLDLTIDNITPNTIRINSQSGDARLTYVMARLVTHLHDFARETRLSTEEWMKAIEFLIACGKICSDEFILLSDVLGLSLLVDSINHPKPVGSTEGSVLGPFHTHDAPLLENGSSMTSDPEGEPMLALCTVKDTKGNPIPGVTIDIWETDSSGHYDVQHAGRDSPSERCVMVSDEEGRFWFKGIKPVSYPIPNDGPVGKLLEKLKRHCWRPAHVHFMFKKEGWDHLITALYIRGDPYETSDAVFGVKKSLIVDLEKVDKETAERYGVMEGIWLLKHDFVLTTEKETEELRDKLATEALQKLGLNLKLVDHLPVPDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0S131</accession>
    <name>G0S131_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative GTP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0012160</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691733.1">
        <property type="nucleotide sequence ID" value="XM_006691670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S131"/>
    <dbReference type="STRING" id="759272.G0S131"/>
    <dbReference type="GeneID" id="18255254"/>
    <dbReference type="KEGG" id="cthr:CTHT_0012160"/>
    <dbReference type="eggNOG" id="KOG2655">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3859">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021805_1_0_1"/>
    <dbReference type="OMA" id="IGRQFPW"/>
    <dbReference type="OrthoDB" id="5337438at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001827">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="3">
        <location>
            <begin position="143"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="361"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="398"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="418"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="433"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS22741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="525" mass="58536" checksum="3A385F017A783343" modified="2011-10-19" version="1">MTPPARRPGLGMLLRRSKSSELKKQRSKEQERQQNAIPNSPPRLPVLYNGAPAPQLGLGDRPDSLAIVSGRIDPTQMNRVAEPRPSMEPPRSAASSIPPPPPVPNGGFDPYPRTTSMTHRSRYSYASAISTINSPRRVRRRKDPTPFNVLIVGTTNCGKTSFLEFLKTALAPPSKKRAKAASPEQDEMPKPSPSGTFIPHYLETEIDGERVGLTLWDSEGLEKNVVDLQLREMASFIESKFEETFTEEMKVIRSPGVQDTHIHAVFLLLDPARLDRNIAAAKAAAANGHNTGLKYYNHSRIVGGLDEDLDLQVVRTLQGKTVVIPVITKADTVTTKHMNMLKKTVAESLKKAKLDPLEALAAADEDSEGDDSASNPDKIVEEDEEQDTRSPTCAPEGDSSSGNDTDLPIQGTNTPPTSKKRHSSRSPRRQQSPEDEEHEAESNEDEIPFLPMSVLSPDMYEPEVIGRQFPWGFADPYNEQHCDFVRLKETVFNEWRAELRELSREHWYESWRTSRLKVHGGKMAQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2023-06-28" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>G0S196</accession>
    <name>ATC5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phospholipid-transporting ATPase DNF1</fullName>
            <ecNumber evidence="13">7.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">CtDNF1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">DNF1</name>
        <name evidence="14" type="ORF">CTHT_0012810</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2020" name="Protein Cell" volume="11" first="458" last="463">
            <title>Structures of a P4-ATPase lipid flippase in lipid bilayers.</title>
            <authorList>
                <person name="He Y."/>
                <person name="Xu J."/>
                <person name="Wu X."/>
                <person name="Li L."/>
            </authorList>
            <dbReference type="PubMed" id="32303992"/>
            <dbReference type="DOI" id="10.1007/s13238-020-00712-y"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.40 ANGSTROMS) IN COMPLEX WITH CDC50; PHOSPHOLIPID AND MAGNESIUM</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>COFACTOR</scope>
        <scope>IDENTIFICATION IN A COMPLEX WITH CDC50</scope>
        <scope>INTERACTION WITH CDC50</scope>
        <scope>1,2-DIACYL-SN-GLYCERO-3-PHOSPHO-L-SERINE BINDING</scope>
    </reference>
    <comment type="function">
        <text evidence="3 10">Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of phosphatidylcholine and phosphatidylserine from the lumenal to the cytosolic leaflet of membranes and ensures the maintenance of asymmetric distribution of phospholipids (PubMed:32303992). May also transport glucosylceramide and phosphatidylethanolamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38583"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:38584"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine(out) + ATP + H2O = a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66036"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:22801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:66037"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of a flippase complex consisting of DNF1 and CDC50 (PubMed:32303992). Interacts with CDC50; the interaction is direct (PubMed:32303992).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endosome membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
            <location evidence="3">trans-Golgi network membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="13"/>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691798.1">
        <property type="nucleotide sequence ID" value="XM_006691735.1"/>
    </dbReference>
    <dbReference type="PDB" id="6LCP">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.48 A"/>
        <property type="chains" value="A=1-1555"/>
    </dbReference>
    <dbReference type="PDB" id="6LCR">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.40 A"/>
        <property type="chains" value="A=1-1555"/>
    </dbReference>
    <dbReference type="PDBsum" id="6LCP"/>
    <dbReference type="PDBsum" id="6LCR"/>
    <dbReference type="EMDB" id="EMD-0872"/>
    <dbReference type="EMDB" id="EMD-0873"/>
    <dbReference type="SMR" id="G0S196"/>
    <dbReference type="STRING" id="759272.G0S196"/>
    <dbReference type="GeneID" id="18255319"/>
    <dbReference type="KEGG" id="cthr:CTHT_0012810"/>
    <dbReference type="eggNOG" id="KOG0206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000846_0_0_1"/>
    <dbReference type="OMA" id="QALRCGR"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070867">
        <property type="term" value="C:mating projection tip membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990531">
        <property type="term" value="C:phospholipid-translocating ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140351">
        <property type="term" value="F:glycosylceramide flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090554">
        <property type="term" value="F:phosphatidylcholine floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140346">
        <property type="term" value="F:phosphatidylserine flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090556">
        <property type="term" value="F:phosphatidylserine floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099040">
        <property type="term" value="P:ceramide translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000048">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000108">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF180">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE DNF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="11320"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0967">Endosome</keyword>
    <keyword id="KW-0333">Golgi apparatus</keyword>
    <keyword id="KW-0445">Lipid transport</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000458217" description="Phospholipid-transporting ATPase DNF1">
        <location>
            <begin position="1"/>
            <end position="1555"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="12">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="12">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="12">
        <location>
            <begin position="178"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="492"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="12">
        <location>
            <begin position="513"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="538"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="12">
        <location>
            <begin position="559"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1124"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="12">
        <location>
            <begin position="1145"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1147"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="12">
        <location>
            <begin position="1168"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1201"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="12">
        <location>
            <begin position="1222"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1238"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="12">
        <location>
            <begin position="1259"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1263"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="12">
        <location>
            <begin position="1284"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1303"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="12">
        <location>
            <begin position="1324"/>
            <end position="1555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="257"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1364"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1489"/>
            <end position="1555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1406"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1436"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1540"/>
            <end position="1555"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="6">
        <location>
            <position position="606"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="606"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="606"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="607"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="608"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="608"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="740"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="781"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="783"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="786"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="804"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="839"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="840"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="919"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="920"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="921"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="1031"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="1037"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="1057"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="1060"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="1061"/>
        </location>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1T8</accession>
    <name>G0S1T8_CHATD</name>
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        <name evidence="4" type="ORF">CTHT_0014780</name>
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    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691990.1">
        <property type="nucleotide sequence ID" value="XM_006691927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1T8"/>
    <dbReference type="STRING" id="759272.G0S1T8"/>
    <dbReference type="GeneID" id="18255516"/>
    <dbReference type="KEGG" id="cthr:CTHT_0014780"/>
    <dbReference type="eggNOG" id="KOG1741">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139869_2_0_1"/>
    <dbReference type="OMA" id="FGLCRNQ"/>
    <dbReference type="OrthoDB" id="413436at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1480:FF:000001">
        <property type="entry name" value="30S ribosomal protein S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_uS14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_uS14_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836:SF19">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US14M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS22998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="113" mass="13058" checksum="9385B1A884C01AAE" modified="2011-10-19" version="1">MSMWRSKKLDIGCFTNVWILRDHAKRKAFAANEPERQALRYIVRNTTLPARTRAIAQLQLTQMHCYTRPTQIKNRCILGGKGKGIFSDFKMSRYNFRLEALAGNLPGVKKASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1X3</accession>
    <name>G0S1X3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF895 domain membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0015160</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS23033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692025.1">
        <property type="nucleotide sequence ID" value="XM_006691962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1X3"/>
    <dbReference type="GeneID" id="18255554"/>
    <dbReference type="KEGG" id="cthr:CTHT_0015160"/>
    <dbReference type="eggNOG" id="KOG3098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030884_1_2_1"/>
    <dbReference type="OMA" id="RIMLYIM"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06178">
        <property type="entry name" value="MFS_unc93-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000726">
        <property type="entry name" value="DUF895 domain membrane protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF59">
        <property type="entry name" value="UNC93-LIKE PROTEIN C922.05C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS23033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="54847" checksum="11BF4C27C40809B2" modified="2011-10-19" version="1">MTDEKQTAPITADGTAPVPRPPGWMYKGIRIGETEVWYASPIVQLLLVAMVCFLCPGMFNALTGLGGGGQVDASAQNDASTALYSTFAVVAFFSGTIANMLGVKATLAFGGLGYCIYAASFLSYNHNQNRGFVVFAGALLGVCAGLLWTAQGTIMMSYPTEDTKGRYISYFWTIFNLGAVIGSLVPLGQNINATGTTNVTDGTYVGFMVLMLAGAVLALFLCNADRIRRHDGSKVILMKNPSWKTEFIGLFETITTGPWVVLLFPMFFASNTFYTYQTNDFNGAHFNTRTRALNNTLYWTSQIIGAVVFGYALDWPRVRRSIRAKASFVVLFILTFAIWGGGYAWQRKQVAREVVESKEVEYQRVDWTDGGERYIGPMFLYMFYGFYDAAWQTCIYWYMGALSNSGRKAANLAGFYKGIQSAGAAVFWRLDGLKKPFDVMFGATWGLLGGALVFAAPVIWLKIKDTVSIEEDLKFSDETVADVVAPEKKTVDSKTESAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0S237</accession>
    <name>G0S237_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0015860</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS23097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692089.1">
        <property type="nucleotide sequence ID" value="XM_006692026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S237"/>
    <dbReference type="STRING" id="759272.G0S237"/>
    <dbReference type="GeneID" id="18255624"/>
    <dbReference type="KEGG" id="cthr:CTHT_0015860"/>
    <dbReference type="eggNOG" id="ENOG502SA8B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029282_1_1_1"/>
    <dbReference type="OMA" id="ANLHIPW"/>
    <dbReference type="OrthoDB" id="2148490at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF65">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX18, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS23097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="412" mass="45171" checksum="AE37B0D66126F307" modified="2011-10-19" version="1">MIARARLRVRPRAIPSRHLLPIVSPSSFRYYSSLFAAYKSSNSHKRISLTPSSHLILPRTQNRTLTILPLLDQAVTLAHTTLTTLHTATGTPWYLTIPLFSLSINLLTRLPATLYSHQLTIRRAKLIPLLRAWGAAVGRVLASNPPPATQGVMLKREAFMVRYAKMVRQVEKEVYQRWGVQGWRFWVPSLAVFPVWLVGIEALRRMCGGPRGLVGSLILGFGREEAGVAGAAAGSTATTAESAATASRNAVDAAVTADPSTLIPWADPTMTTEGALWFTNLTVADPYHILPLALSAVLIGNMLPRNTSGLRTLFHTNLTPSEQSSLTGPAGRALRWRLRLRRTLLVFAAAVGPLTMDLPAALHLYWLSSAALTWAETSLLAWWRPIPKAPSPARKDTAVVVRPLRDGRVMVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2F3</accession>
    <name>G0S2F3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Putative ER to golgi transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CTHT_0017030</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692205.1">
        <property type="nucleotide sequence ID" value="XM_006692142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2F3"/>
    <dbReference type="STRING" id="759272.G0S2F3"/>
    <dbReference type="GeneID" id="18255741"/>
    <dbReference type="KEGG" id="cthr:CTHT_0017030"/>
    <dbReference type="eggNOG" id="KOG1984">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004589_1_0_1"/>
    <dbReference type="OMA" id="INPFMTF"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF4">
        <property type="entry name" value="SECRETORY 24CD, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="12">
        <location>
            <begin position="269"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="13">
        <location>
            <begin position="344"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="15">
        <location>
            <begin position="603"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="14">
        <location>
            <begin position="699"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="11">
        <location>
            <begin position="832"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="147"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGS22186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="992" mass="108656" checksum="0812619FC5D99A19" modified="2011-10-19" version="1">MSEYAMYHALGYGEPLDPNDPSRTTQPAPPQFQPPIAPNPYQQQQQQQAPRAPADTLAAQMGAMSLGDGQHHAPTTAKKKKRDRHAYHTVEAPAGSSQPFNGIPPAGTPATAYLNNDPSVAHSQFPAPVNPPFTPTPASPLEFAARQGHEGVPAAVSTQSGPGSGAGRPSPDEMPSVPVSRDSVQPHYYNNVYPTFQRLVPPPATVSYVAFDQGNASPKFARLTLNSIPATADGLKMTALPLGLILQPLAPLQAGELEIPVLDFGDAGPPRCHRCRAYINPFMVFRQGGNKFVCNLCGYPNDTPPEYFCATSPQGIRIDRDQRPELTRGTVEFLVPKEYWTREPVPLRYLFVIDVTQDSYNKGFLEAFCDGILRALYAPDPADEQPADENGELPRRIPPGAKVGFITYDKEVHFYNVSPALEQAQMIVMPDIEDPFVPLGDGLFVDPYESKAVITSLLTRLPQMFSTIKNPEPALLATLTAAVAALEKTGGKIFCSLSALPTWGPGRLFMRDDGKHPGGEPDKKLFSTEHPAWRKMADKMVSIGAGVDFFMASPSGGYLDIATVGYVAATTGGETFYYPNFIAARDTAKLALEIKHAVTRETGYQALMKVRCSNGLQVSAYHGNFVQHTFGADLEIGVIDADKALGVTFAYDGKLDPKLDAHFQAALLYTSSSGQRRVRCINVVASVAENARDCIKFVDQDAVVTLIAKEASTRLATTSATLKDIRASIQERTIDVLANYRKHFLTVPHPPGQLVMPERLKEFAMYMLAMLKCRAFKGGAEPTDRRVHDMRLIRSVGARELSYYLYPRIIPIHNLAPEDGFPDEQSGGNLRMPASLRASFARVEPGGVYIVDNGQICILWFHAQTSPNLLMDLFGEDKTSLQSLDPYVSELPVLQTHLNAQVRNILEFLRTMRGSKGLVVQIARQGIDGAEFEFARMLVEDRNNEASGYVDWLVNIHRGVQLELAGQRKREDGGSHDSSGLAGFSGLRPMYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2I3</accession>
    <name>G0S2I3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LCCL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0017330</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692235.1">
        <property type="nucleotide sequence ID" value="XM_006692172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2I3"/>
    <dbReference type="GeneID" id="18255771"/>
    <dbReference type="KEGG" id="cthr:CTHT_0017330"/>
    <dbReference type="eggNOG" id="ENOG502QUEX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011125_1_0_1"/>
    <dbReference type="OMA" id="WLGAMAN"/>
    <dbReference type="OrthoDB" id="441660at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.20">
        <property type="entry name" value="LCCL-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051957">
        <property type="entry name" value="CRISP-LCCL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004043">
        <property type="entry name" value="LCCL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331:SF8">
        <property type="entry name" value="LCCL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G02970)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331">
        <property type="entry name" value="LCCL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G08630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03815">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69848">
        <property type="entry name" value="LCCL domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="424"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="472"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="LCCL" evidence="3">
        <location>
            <begin position="170"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS22216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="658" mass="73585" checksum="1917A3221915CD35" modified="2011-10-19" version="1">MATKPLAESSKANDEETQLLADEDYDVYELDDRSRPIPRGVCPHCHRQLGQQRQQNQGENDVDVLWCCWERSNAPNWVCRWDDEWRHVTLRDLGFKEWDGTSVACAWQAAPRQLFLHLVPRPGWRALLTAIFLVLWASTFKYLVDQEIQSKPRVVPSTSVDAGLPVRYLDCTDSLWGSFGEGCGLNGANCRPFSNVSFVFRCNGWCTDNKTHFDPYHVGRLVVDRSPLVIGGGAGSPYRGDSFICPAAVHAGLKDGCGKVTLTGEYYQFFNSSQNNVDSISFPSYFPLSFTVSKTDICPPLPGSLVMKIAFPLTIVFTVIISLLTTSPALMFFSAFIGVYTTCSFIRSATAGVTDMSLRVSKFSSSLPSVLCIAGVLYLTIVRYPLRAFPASAALVKIGSWLLPFWLGSTTPLLGYHGTEAFKGWLLLIIIWAITGCTALLDGYFWHRLALFAALIVSPLLALAIDPNWKSNYLSWQFFAFVMLLPLLAPKHRWWFIIAFCLGIFTSGMALDGGLGPVLKPNPFQLSTPEPFPGAHHLLPTVLPPMVKQVAPGYSKSWGIWFKFQWPQNATLTEAEAIRSGAVTGLSIMVNDVERFRGWFAEKPLEDMMFSWTRERGLNTADEFFRFGFLGQGGRPLRYTEAGMWFRNGSWSHGEGYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2Q0</accession>
    <name>G0S2Q0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWR1-complex protein 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0018040</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692302.1">
        <property type="nucleotide sequence ID" value="XM_006692239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2Q0"/>
    <dbReference type="STRING" id="759272.G0S2Q0"/>
    <dbReference type="GeneID" id="18255842"/>
    <dbReference type="KEGG" id="cthr:CTHT_0018040"/>
    <dbReference type="eggNOG" id="ENOG502QWM7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013601_0_0_1"/>
    <dbReference type="OMA" id="LQYGPPN"/>
    <dbReference type="OrthoDB" id="5338195at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140849">
        <property type="term" value="F:ATP-dependent H2AZ histone chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037651">
        <property type="entry name" value="Swc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057558">
        <property type="entry name" value="Swc3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28108">
        <property type="entry name" value="SWR1-COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28108:SF1">
        <property type="entry name" value="SWR1-COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24707">
        <property type="entry name" value="Swc3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWR1-complex protein 3" evidence="2">
        <location>
            <begin position="67"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="682"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="709"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="745"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="780" mass="83397" checksum="B3A8508252757A07" modified="2011-10-19" version="1">MEKKRKLPARAAARAEQAAKRRHTSPPARSATPAPASEPDPEPASPEKEKEKEPPPPLPTSITPGKPLPAVESPQPDDLPDSEYQTVAESGVLGESIRRSRHKWIIGEGMFEKYWTKPVKKRGVVIEEPNNPPKDSMTKIGQVQIVVDPHVFDAVLYAVRDPKPPPPPPPDKRPIIEYGPRNGAMQPPPTPGATTPATPSVPAQGQAPPSIESAPAGPAQPSPSPAPTASAPQPPPAPPAPVQSSVNTSPSTSSMPTAAPAAPPIVSPRGMENVLSPAPAQAQPMPPAQPLAASEPPPPAAPSTHPTAPPTPASGPVAAPAPAPAPPSNGPPTTPTPAPPKPGTDPIILMLAERAGGDPQLRELMKRVAQGNAEQHELQKFQSIIDALTAESKQQRKGPTAAELTIANDGRSVQWFADQVRDILFIVQRTNPRETGSTLIPPPNSDPLCIMLARKALDDIRTRDIVRRVADRRPLFSDAPDLKAILDDFKSKLIKAQEAQKQAQAPALNARAKGATAGQHSNQVNGKPSPAPQQALRSKGPPPPPKPDISAIVVEFVGGNGDRYLFPRYSLLEYKPLPPGQSGQQVYASFLIVHRGSQSEYPVADPSRDYWQAITIRLYAPTGDHLEQLQHVVAPREEVLKYFETVKNSMTRGEYILLAWRLRKKQAGEESEEEEDGGKMPAGKDKEKEKEKGKGKAVNGSSTPAPAGKGKENKEKEKEDALASKKKAGANTGGVLWTTSGKQLPKPELRDLPKGRSYGRAMDADENYQSFIASVSKKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2V1</accession>
    <name>G0S2V1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0018580</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692353.1">
        <property type="nucleotide sequence ID" value="XM_006692290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2V1"/>
    <dbReference type="GeneID" id="18255896"/>
    <dbReference type="KEGG" id="cthr:CTHT_0018580"/>
    <dbReference type="eggNOG" id="KOG1201">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_5_0_1"/>
    <dbReference type="OMA" id="MMPPARI"/>
    <dbReference type="OrthoDB" id="10253736at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS22334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="360" mass="39729" checksum="83364F75DF6C656C" modified="2011-10-19" version="1">MATYREYGGFHIDTLGRAVRKTLLNESITLPLALAATYLSQPSSAAILTKLLHYITTLGINPKTLNLPKFARLALYLGATGLALTTNDTLNKWVANNWTRNSRSEWADWSKEIVVVTGGSSGIGQHIVQGLLKRNPRTTIVIVDFAPLSWVPPEGMLGKTLHYYQADLSKADVVEDVCARIRKEVGHPTVLVNNAGICRGFTIADGTYADTDATLRTNLTAPFLLIKEFLPHMVSTNHGHIVNISSMSAVVPPPEMVDYAASKAGLFAMHEGLSLELKYRYKAPKVRLTCLLPNFIRTPLLTGKARHPKQPQFFAPLLDVETKGGPEWLFRTLVFSTTRNMDVEFKGRQKIDETGGLMAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0S342</accession>
    <name>G0S342_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aldose 1-epimerase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0019580</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldose epimerase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692444.1">
        <property type="nucleotide sequence ID" value="XM_006692381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S342"/>
    <dbReference type="STRING" id="759272.G0S342"/>
    <dbReference type="GeneID" id="18255996"/>
    <dbReference type="KEGG" id="cthr:CTHT_0019580"/>
    <dbReference type="eggNOG" id="KOG1604">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031753_0_1_1"/>
    <dbReference type="OMA" id="HWESSWE"/>
    <dbReference type="OrthoDB" id="274691at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09019">
        <property type="entry name" value="galactose_mutarotase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000014">
        <property type="entry name" value="Aldose 1-epimerase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047215">
        <property type="entry name" value="Galactose_mutarotase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF2">
        <property type="entry name" value="ALDOSE 1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409256" description="Aldose 1-epimerase-like protein" evidence="4">
        <location>
            <begin position="19"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS22425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="42956" checksum="9C3A1749D3F479C0" modified="2011-10-19" version="1">MRLSALILAAVADAVVLARCDSAPKIDEDGRYTISAPGIKAQFIPYGATLTNLFVKDKNGEDIDVVLGYDDVDYYPVDPGHPVYNAIPGCYAGRIGKARYTIDGVTYETERNDGENTLHSGTNNWSFRYWNVTAYTADSITFSLLDESESSKGFPGRVEANVTYSVTNNTWHIKMTAHSLDNKTPILLTQHTYFNLDAYRNPATSLIWNHTLALPYSPRYLEADDAALPTGKILTAAANSINDFHSAGHEGRPLGHSRHLPQFAGNCGGGGMCEGYNGYWLFDDIPETKDGEERPVVVVLSSEFSGVKAELRTDQPGVVVYTCNWMNGSAKLKSTQGLEGRDTVGRSSCIAIEAQEWPDGINHPEWGRLEKQIFGPGQRYSWESSWTFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0S397</accession>
    <name>G0S397_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tetrahydroxynaphthalene reductase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0020210</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692499.1">
        <property type="nucleotide sequence ID" value="XM_006692436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S397"/>
    <dbReference type="STRING" id="759272.G0S397"/>
    <dbReference type="GeneID" id="18256059"/>
    <dbReference type="KEGG" id="cthr:CTHT_0020210"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_1"/>
    <dbReference type="OMA" id="EYACTWS"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05362">
        <property type="entry name" value="THN_reductase-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF7">
        <property type="entry name" value="RE15974P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS22480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="29840" checksum="275E8B55B78837A9" modified="2011-10-19" version="1">MSSVAGKPAGKYDEIPGPLGLGAASLAGKVALVTGAGRGIGREIALELGRRGAKVIINYANSEATAQEVVNQIKKNGSDAASVKANVSDVDQIVRMFEEAKKIFGKIDIVVSNSGVVSFGHVKDVTPEEFDRVFNINTRGQFFVAREAYKNLEVGGRLIMMGSITGQAKMVPRHAVYSGSKGAIETFVRCLAVDFGDKKCTVNCVAPGGIKTDMYHAVCREYIPGGDKLNDEEVDEYAAGWSPIHRVGLPIDVARVVCFLASQDGEWINGKVIGIDGGACM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3D0</accession>
    <name>G0S3D0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0020570</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692532.1">
        <property type="nucleotide sequence ID" value="XM_006692469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3D0"/>
    <dbReference type="GeneID" id="18256095"/>
    <dbReference type="KEGG" id="cthr:CTHT_0020570"/>
    <dbReference type="HOGENOM" id="CLU_2793779_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="68" mass="7056" checksum="01FF7C2683FC90FB" modified="2011-10-19" version="1">MNDTGSATGNNIDPLAVNNFGSPAADSIDSAVNTTGSPDNTHNVKVHYHGSIQNTGSGNVILVTFDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0S425</accession>
    <name>G0S425_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sidoreflexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0022300</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sideroflexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692697.1">
        <property type="nucleotide sequence ID" value="XM_006692634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S425"/>
    <dbReference type="GeneID" id="18256268"/>
    <dbReference type="KEGG" id="cthr:CTHT_0022300"/>
    <dbReference type="eggNOG" id="KOG3767">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039425_0_0_1"/>
    <dbReference type="OMA" id="GRVRHCA"/>
    <dbReference type="OrthoDB" id="6608471at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:monoatomic ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990542">
        <property type="term" value="P:mitochondrial transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004686">
        <property type="entry name" value="Mtc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00798">
        <property type="entry name" value="mtc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153">
        <property type="entry name" value="SIDEROFLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153:SF6">
        <property type="entry name" value="SIDEROFLEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03820">
        <property type="entry name" value="SFXNs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS20401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="343" mass="37367" checksum="80831050B0D65AB6" modified="2011-10-19" version="1">MSASLPGGRQLPESQYDLSTYWGRVRHCASITDPRTLFVGSRGLEEAKNLLISYKQGQIKHMTPDLWRAKKIVDSTLHPDTGEPVFLPFRMSCFVLSNLVVTAGMLTPNLGTRGTIAWQVANQSLNVAINYSNANKSSPLSWSKIAQSYFLAVTASCSVAVGLNNLVPRLKNLAPNTRLILSRLVPFAAVASAGALNVFLMRAEEMRTGIDVFPARKPVALSEKEADAAVSEEEGAPQSLGKSKKAATLAVAETALSRVLNSSPIMVIPPLILVRLQRTEWLKKNPRYTTPVNLGLILVTSYAVLPLALAAFPQRQRVKAESLEEEFHGRGGEDGLVEFNRGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4A9</accession>
    <name>G0S4A9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome maturation factor UMP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0039520</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the POMP/UMP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS22067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694363.1">
        <property type="nucleotide sequence ID" value="XM_006694300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4A9"/>
    <dbReference type="STRING" id="759272.G0S4A9"/>
    <dbReference type="GeneID" id="18257990"/>
    <dbReference type="KEGG" id="cthr:CTHT_0039520"/>
    <dbReference type="eggNOG" id="KOG3061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100687_0_0_1"/>
    <dbReference type="OMA" id="MSMRIVP"/>
    <dbReference type="OrthoDB" id="15001at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008012">
        <property type="entry name" value="Ump1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12828:SF3">
        <property type="entry name" value="PROTEASOME MATURATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12828">
        <property type="entry name" value="PROTEASOME MATURATION PROTEIN UMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05348">
        <property type="entry name" value="UMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="17622" checksum="80499FFE0BC81263" modified="2011-10-19" version="1">MSLRIVPAQENHTSFTHLPSHSYVAPSAPGLHDTLRAGVGPSAFHPQTQPISSHPLESRLRKWHATQESLRMETLRRTFGMAEPIRRQMELKIVKEGEWKPMCLGGGVRKGVHEEILRGTDCDIEWEDVFVQEESMPMVGFHEEVERKLKMDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4L2</accession>
    <name>G0S4L2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0031400</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693583.1">
        <property type="nucleotide sequence ID" value="XM_006693520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4L2"/>
    <dbReference type="STRING" id="759272.G0S4L2"/>
    <dbReference type="GeneID" id="18257178"/>
    <dbReference type="KEGG" id="cthr:CTHT_0031400"/>
    <dbReference type="eggNOG" id="KOG0590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_82_1_1"/>
    <dbReference type="OMA" id="PWKVPRM"/>
    <dbReference type="OrthoDB" id="6513151at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000595">
        <property type="entry name" value="Protein kinase, putative (AFU_orthologue AFUA_5G11840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF137">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE HRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="390"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="98"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="244"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="310"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="644"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="218"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="320"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="644"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="658"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS21287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="760" mass="82959" checksum="F3D76C84125192A4" modified="2011-10-19" version="1">MTTSTTVGDLNVRTGDAVRITTQTPNSHPIQSPPAVRFKSTIEEIAIAPNDAPSSTLPAADGTAGSLSDPGQVTTDEIREFSNRLSAWPPQERKMNIFSYEPFSLPPSRSTSRDDESREPSRQPTQSSGGHGSPCLTSSARGADMNSPPLTPAGTGFAEGGQKREPSGNHEPISRGPDIIAPHESTQEPSSPASAQLAVPHVTMADRGRLARRPATSEGRDQMQHTPLGDHRRGLFSIGAASASVSPASSVSPSRDSSPSRAATASQFYTRQILPPAEADDPYAASRRPAQKGIEPRFIFAKKKKHSSSSSSLLSLPRALGDKRQSDDGITHSRNSSMADLKRFFKLVPTSKSKRTASPAASIRSGKTSSSAKGAQIPFGDDHGLSSKYGKLGKVLGAGAGGSVRLMRRAEDGVVFAVKEFRPRHSYETEREYVKKLTAEYCMGSSLHHGNIIETLDIVQERGKWYVVMEYAPYDLFAIVMTGKMTREEISCCFLQILSGVTYLHSMGLAHRDLKLDNVVVSERGIMKIIDFGSAHVFKYPFESGLVLASGIVGSDPYLAPEVYDEKKYDPQAVDIWSLAIIFCCMTLRRFPWKIPRLSDTSFKLFAAEPTPGHDPKKLILPHSASMTAVNDTPARDFDQQALEKEDGKRAKEEPISKSENATGEASNQQDGKPQQPAPAGEKKETIRGPWRILRLLPRETRYIIGRMLELDPKKRATMQEILDDPWVANTVICRQAENGQVFNADDHTHVLEPPSPPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4P7</accession>
    <name>G0S4P7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WHIM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0023080</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692772.1">
        <property type="nucleotide sequence ID" value="XM_006692709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4P7"/>
    <dbReference type="STRING" id="759272.G0S4P7"/>
    <dbReference type="GeneID" id="18256346"/>
    <dbReference type="KEGG" id="cthr:CTHT_0023080"/>
    <dbReference type="eggNOG" id="ENOG502QSZU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023536_0_0_1"/>
    <dbReference type="OMA" id="HYGPQDI"/>
    <dbReference type="OrthoDB" id="349045at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028942">
        <property type="entry name" value="WHIM1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42107:SF1">
        <property type="entry name" value="WHIM1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42107">
        <property type="entry name" value="YALI0D24453P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15612">
        <property type="entry name" value="WHIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WHIM1" evidence="4">
        <location>
            <begin position="155"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="344"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="576"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="360"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="385"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="439"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="508"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="526"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="584"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS20476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="644" mass="71896" checksum="B49B10773FED38E8" modified="2011-10-19" version="1">MADDDSSELSSLSSLSPPPSDSESDIQLEERHGILKFFHKVDRNPNLETPKEKTPPRPKREPSPPHEYVFADNPDIAFIVMFRARFTEAFPKSLANFGPHELERDVSEPIPGERVEHFLCALLSLLLNRKQDVKPGHYNRALEEAIQTHKGQWAKDWESKNPLAGGATFTTMTRDQRLTLLRTLVQWTLSSSDTIRQMINKAYRNRHEDDLNIPLSVQPWGSDGDKRRYYLIEGNDDTSFRVYRESNPAGLQRTWWSVAGSIDELKALAEKLETQDGGPKAKALAKKIQAAIPRFEATEEKRRRREYRQMRKEQFRRPEGFSLYEGRTRGKRIKYTFSDDENDFFSDEPVLRRSSRNTRNHTPAPSGPITTASGRQVKPPNRLNAETASTGAPSAATSFQGDTSDAGAPRTTRSGRPLRSAAAKLNGFAGGRKRKSSEFESDESEGSEPDFGDDEEEDEHVPDETEEYDEDEEFEDAELSEDDLETTAIGRSTTDAGRKKSLIIKFPIRVEFDENHKVRQIPGPPGEKRPSDEEKTETAPVQPNPAKETISVATTKCMTPVEADKPMIEKVQAISGANNVCDKTVPEPEDKPLTDAPVGLQSPPTPTSEPATSLALRGSPEVTRTGPPPTSTAALASEDVSMQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4S2</accession>
    <name>G0S4S2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Brix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0023330</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="5 6 7" key="2">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e56910" last="e56910">
            <title>Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation during pre-60S biogenesis.</title>
            <authorList>
                <person name="Lau B."/>
                <person name="Huang Z."/>
                <person name="Kellner N."/>
                <person name="Niu S."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
                <person name="Cheng J."/>
            </authorList>
            <dbReference type="PubMed" id="37129998"/>
            <dbReference type="DOI" id="10.15252/embr.202356910"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.00 ANGSTROMS)</scope>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692797.1">
        <property type="nucleotide sequence ID" value="XM_006692734.1"/>
    </dbReference>
    <dbReference type="PDB" id="8I9P">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="Cd=1-436"/>
    </dbReference>
    <dbReference type="PDB" id="8I9R">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="Cd=1-436"/>
    </dbReference>
    <dbReference type="PDB" id="8I9T">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.60 A"/>
        <property type="chains" value="Cd=1-436"/>
    </dbReference>
    <dbReference type="PDB" id="8I9V">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="Cd=1-436"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4S2"/>
    <dbReference type="EMDB" id="EMD-35279"/>
    <dbReference type="EMDB" id="EMD-35281"/>
    <dbReference type="EMDB" id="EMD-35283"/>
    <dbReference type="EMDB" id="EMD-35285"/>
    <dbReference type="SMR" id="G0S4S2"/>
    <dbReference type="STRING" id="759272.G0S4S2"/>
    <dbReference type="GeneID" id="18256371"/>
    <dbReference type="KEGG" id="cthr:CTHT_0023330"/>
    <dbReference type="eggNOG" id="KOG2780">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040063_3_2_1"/>
    <dbReference type="OMA" id="HFSVSNW"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Similar to RNA processing factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF3">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5 6 7" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="197"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS20501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="8I9P"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="8I9R"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="8I9T"/>
        </source>
    </evidence>
    <sequence length="436" mass="49381" checksum="AB85B38E50210C1D" modified="2011-10-19" version="1">MAASKSKDLSRVSLARTIGNKLKRQQLYIQAKKANSRAKHEERHRRRKEEAKNPELKQKRLEKNQPASIDKKRIWDDLDDDSLGAVVDVAELKRRRLEVAEAAAAAEADAAAREDQEVDDKNDENEKRDDDIDSMLGSDDEDEEDEGAKKEKEEEMQRQRAQRQPSIAPSTTSTNLDLTPDSLTSQFPNLFADEPPPVPKILVTTGINGTIHKEAEEIASIFPNATYIRRTAHRYAYKYSVREIAKFAKNRGYTALLVVQEDQKRPSRLVVVHLNGEGVPPGPTLTYTIRNYAPGKAIPGHGRATNHYPELLLNNFKTPLGLLAAKSMHILFPSKPELAGRQVVTLHNQRDYIFFRRHRYVFREARPTEKNVVGADGKEMEGVKGIRAGLQEIGPRMTLKLRRVDKGVGRAGSEGPDAVKWEWKAKMEKKRTRFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4T8</accession>
    <name>G0S4T8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0023490</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692813.1">
        <property type="nucleotide sequence ID" value="XM_006692750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4T8"/>
    <dbReference type="STRING" id="759272.G0S4T8"/>
    <dbReference type="GeneID" id="18256387"/>
    <dbReference type="KEGG" id="cthr:CTHT_0023490"/>
    <dbReference type="eggNOG" id="ENOG502RF8N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015502_0_1_1"/>
    <dbReference type="OMA" id="WDLFIID"/>
    <dbReference type="OrthoDB" id="5367487at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="59"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS20517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="660" mass="72906" checksum="F0940F873D492235" modified="2011-10-19" version="1">MEPFSPAAPQLSAATTGGSPSVSSDSPGTATTSATPHLSSATAEAQPSQPPAQQAVPAACLACRAKHLRCDGTNPCSRCVSNRTECVYVPSRRGYKGPRRGTAQNPNKRHASDSPPYVGPAESCPMLLGHNPVSVTTSVPGFNPSIVLPDQSPLSYTSPSPLTANIHSLYRNPFAPAGMDANTLALTTAPVSVVPSNTTAQPPVPSLADRCFDAFYHYFHASHPFVLPREHFLRLLKEGISPNMNIVMAAMRYIGALFVDAGPAKANYLDEALRLCYQPSTQKDGFLIQALLLLIIGLDGETNRDKSRELLADCERFAIEIDLNKRQFASLHGRGNPVLEESWRRTWWDLFVVDGMIAGVHRATNFLLYTVDTDVALPCEEHEYFSGQIPRHPLTLEDFEDQTFSGEDREFSSFAYRIAAARNLGYMMHNMPQTPFPDDNRILHIESLLTNWRLHLPESKRDDLGKNCQLDEMMFQAHFITHACTILLHQPLSQLDTSPAKAVNSCAPHRPVPSGESFNSHTRHTITAACEISKMITQAVPIIHHTHFFTCVITLSSIVHLSRWAQYMVEPTGGDDDLRQQIRLNIGGLNKLRKVWKAAECAWGQVKGVAQEIYRQKKAHQISPAFWVGFTEEQMIRSINADEGIMSEFTNVMNGQVTQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4V2</accession>
    <name>G0S4V2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0031780</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693619.1">
        <property type="nucleotide sequence ID" value="XM_006693556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4V2"/>
    <dbReference type="GeneID" id="18257216"/>
    <dbReference type="KEGG" id="cthr:CTHT_0031780"/>
    <dbReference type="HOGENOM" id="CLU_2037794_0_0_1"/>
    <dbReference type="OMA" id="PPVEVGH"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="124" mass="14374" checksum="97101DB4EACFE0FA" modified="2011-10-19" version="1">MPGCLTLLRFWRKRKQDDEAATVQVKEKYGTFDRPQIANSKKTSTDSSFDDPLKNSKTKVQVSYMPHPTCNPIYSAYAAPKDLAWINATQTRPVSGHTDETEETARRRKTEEEEQERLNFFQML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2023-02-22" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>G0S552</accession>
    <name>G0S552_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0032260</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693667.1">
        <property type="nucleotide sequence ID" value="XM_006693604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S552"/>
    <dbReference type="GeneID" id="18257264"/>
    <dbReference type="KEGG" id="cthr:CTHT_0032260"/>
    <dbReference type="HOGENOM" id="CLU_2497694_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408924" evidence="1">
        <location>
            <begin position="19"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="86" mass="9852" checksum="29214C93A17BFFDB" modified="2011-10-19" version="1">MLVYFLAMLVVPGPEICAWDDLSDLVMLAWNSTPTLQNLKQSTLGVWYKRYWGIRLGIRVDDATGKPMLVAAEEGEKKLEEDMKYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5W9</accession>
    <name>G0S5W9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor CWC22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pre-mRNA-splicing factor cwc22</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0025210</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2025" name="Cell Res." volume="35" first="296" last="308">
            <title>Structural insights into spliceosome fidelity: DHX35-GPATCH1- mediated rejection of aberrant splicing substrates.</title>
            <authorList>
                <person name="Li Y."/>
                <person name="Fischer P."/>
                <person name="Wang M."/>
                <person name="Zhou Q."/>
                <person name="Song A."/>
                <person name="Yuan R."/>
                <person name="Meng W."/>
                <person name="Chen F.X."/>
                <person name="Luhrmann R."/>
                <person name="Lau B."/>
                <person name="Hurt E."/>
                <person name="Cheng J."/>
            </authorList>
            <dbReference type="PubMed" id="40016598"/>
            <dbReference type="DOI" id="10.1038/s41422-025-01084-w"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.90 ANGSTROMS)</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692981.1">
        <property type="nucleotide sequence ID" value="XM_006692918.1"/>
    </dbReference>
    <dbReference type="PDB" id="9L5S">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="Z=1-678"/>
    </dbReference>
    <dbReference type="PDB" id="9L5T">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.50 A"/>
        <property type="chains" value="Z=1-678"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5W9"/>
    <dbReference type="EMDB" id="EMD-62842"/>
    <dbReference type="EMDB" id="EMD-62843"/>
    <dbReference type="SMR" id="G0S5W9"/>
    <dbReference type="STRING" id="759272.G0S5W9"/>
    <dbReference type="GeneID" id="18256559"/>
    <dbReference type="KEGG" id="cthr:CTHT_0025210"/>
    <dbReference type="eggNOG" id="KOG2140">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006308_3_3_1"/>
    <dbReference type="OMA" id="ILTEDMR"/>
    <dbReference type="OrthoDB" id="3938623at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000004">
        <property type="entry name" value="pre-mRNA-splicing factor CWC22 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF3">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="14 15" id="KW-0002">3D-structure</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="MI" evidence="11">
        <location>
            <begin position="352"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="308"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS20685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="9L5S"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="9L5T"/>
        </source>
    </evidence>
    <sequence length="678" mass="76420" checksum="813858E0DA92B39C" modified="2011-10-19" version="1">MASADSAAAAAKTEEQKLAEQRAEYQKLLELRSQGVYLPPHKLRALQAAITDPKTKEYQRIAWDALKKSINGLVNKVNTANIKHVVPELFNENLIRGRGLFCQSLLKAQHASLPFTPIYACMAAIVNTKLPQVGELLVKRLIMRFRKAFKRNDKPVCLSSTMFIAHLVNQQVVHETLAGQILVLLLQKPTDDSVEIAVGFMREVGLFLEEMAPRIAHIVFDQFKNILHEADIDRRTQYMIEVLFQIRKDRYKDNPVIKEELDLIEEEDQITHRISLDEDINTEDSLNIFKYDPEWEENENEYKKLKAEILGEVSGDEDEEDEDEEDEESEESEDEEQKAIEIRDQTNADLVNLRRTIYLTIQSSADPEEAAHKLMKLKLPPGQEPELVSMIIESCAQEKVYSKFMGLLGEKFARLNRMWMELYEEAFTKYYNTIHRYETNKLRNIARFFGHLLSYDAIGWHVLSVIQLTEEETTAASRIFIRFLFEDIQENLGTAKLKARLGDEALQPYLEGIFRHDTRRNVTFAINYFTAIKMGYLTDEMHPGRHHGRGLGPEVALRRVPLFVGPDPTAGAGAGAGTGAAGATPAAPAGAEAAPEIIPALFPQEVGADPSLARFLAHHPLVVKQESLTGAVSGSKEAEKVEVEVEVEVKVEDTAEARRAVQQVSVAVKVPIEVCVPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0S648</accession>
    <name>G0S648_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable electron transfer flavoprotein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0034170</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="9 10">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693852.1">
        <property type="nucleotide sequence ID" value="XM_006693789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S648"/>
    <dbReference type="STRING" id="759272.G0S648"/>
    <dbReference type="GeneID" id="18257455"/>
    <dbReference type="KEGG" id="cthr:CTHT_0034170"/>
    <dbReference type="eggNOG" id="KOG3954">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034178_0_0_1"/>
    <dbReference type="OMA" id="WRPYAEQ"/>
    <dbReference type="OrthoDB" id="1715808at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000041">
        <property type="entry name" value="Electron transfer flavoprotein alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000001">
        <property type="entry name" value="Electron transfer flavoprotein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153:SF1">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 9 10" id="KW-0274">FAD</keyword>
    <keyword evidence="5 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="11">
        <location>
            <begin position="39"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="266"/>
            <end position="267"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="280"/>
            <end position="284"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="297"/>
            <end position="304"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000089-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS21556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="353" mass="36443" checksum="B8C91265A80523F4" modified="2011-10-19" version="1">MLSSAGRRAFAALARPTLRSDVAFAFRPSPAALRRLLSALAVLEQRDGKLNAGSLSAVTAAKQLGGSVHGFIAGSNIKAVAEEAAKIEGVEKIIAVDNPAYDKGLPENYAPLLVENIKKGGYTHVVAGTTAFGKNVMPRVAALLDSQQISDITAVQDDKTFVRPIYAGNAIATVESTDAVKVITVRGTAFPAAAVGSGSAAVEEGVDPKADSPTEWVSEDLAKSDRPDLATASRVVSGGRGLKSKEDFDRIMLPLADALGAAVGASRAAVDSGYADNSLQVGQTGKVVAPQLYVAVGISGAIQHLAGMKDSKVIAAINKDAEAPIFQVADVGLVGDLFEKVPELTEKLKKAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7A8</accession>
    <name>G0S7A8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0036190</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694048.1">
        <property type="nucleotide sequence ID" value="XM_006693985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7A8"/>
    <dbReference type="STRING" id="759272.G0S7A8"/>
    <dbReference type="GeneID" id="18257657"/>
    <dbReference type="KEGG" id="cthr:CTHT_0036190"/>
    <dbReference type="eggNOG" id="ENOG502SF40">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018830_1_0_1"/>
    <dbReference type="OMA" id="PFNDPVN"/>
    <dbReference type="OrthoDB" id="5340910at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="376"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="48"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="179"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="270"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="430"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="181"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="222"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="324"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="494"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS21752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="514" mass="53968" checksum="9521E2007B25D99D" modified="2011-10-19" version="1">MIWPRAGPVRRQDPGSSSTLPPMITEAPTAVPTTGDVLVVATDPVKPTTFHTTSAPSVTQTPQSSQAPTSQTSSGDGGGGLTMATKAGIIMGTLGGILVIFVLVWLIYSARKKVVERRRRQLEDDEKINGPFSDSAAIRTPATAPRLSLRPVTQFLPSFNTTSHTETTASRGIALTLNPVASPSPTTSLSPLARPTGASAWERPTIDSIQSAPDAYRHKRTGTNTSQHPNNPFNDSQRVQDEPVSPISSVGSLEQRNRLAVGTGADAVSALSEPVSPIDDSDNEKDNRIGVAKTTPGNGAVPSSVGRRTSMRKDLPKPLDLTKAAASSSSLSSSQLYAAQPPSPAGTEYSMQSIAPGQTPVPTAGAAAIAAAGGPQHSTVHRVQLDFKPTLEDEMELKAGQLVRLLHEYDDGWALVIRLDRSEQGVVPRTCLSTRPVKPRTNPNNNPGASLRGGPPVNPSYGHRHQNSFSRPRSPHSPGLPIQSNTSRPSSPAGGYGGRGGYGYGQGAPPGQAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7D8</accession>
    <name>G0S7D8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative aminotransferase class I and II family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0036500</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694078.1">
        <property type="nucleotide sequence ID" value="XM_006694015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7D8"/>
    <dbReference type="STRING" id="759272.G0S7D8"/>
    <dbReference type="GeneID" id="18257688"/>
    <dbReference type="KEGG" id="cthr:CTHT_0036500"/>
    <dbReference type="eggNOG" id="KOG0256">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_1_2_1"/>
    <dbReference type="OMA" id="TGWYRIT"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF39">
        <property type="entry name" value="AMINOTRANSFERASE CLASS I_CLASSII DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="2">
        <location>
            <begin position="27"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS21782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="410" mass="46271" checksum="EAA56AC5F2920332" modified="2011-10-19" version="1">MHQEISKYLNENLTVDPICHLTYGFGPKGSPRLRKALAAFLNSNFRPRTPVQPDELVVLNGVTSVVDTLTWSICNEGEGIIIPKPFYTGFAVDIQTRAKGVIVPALFQPLEEYQGFDDVFSASHNIKALENALKEAEEKGIKVRAFLLTNPHNPLGRCYPVEAIKEIARFCSHHNLHLISDEIYANSVFDNAQTPDAIPFSSILSLDLDGIIDSQFVHVAYGASKDFCVNGLRLGMLYTRNQGLLGSMASNSMLQWPPYVIQDVWAKILEDEEFTRNFFATNRQRLGTQFARATKFLDDHGIPYYKKANAGMFIWIDLRRFLVGLPAGADVPNLSIHRLSPEEKQEYQRREKEIGSRLRKNGVVIALGSNFFTEELGWFRLSFTAVKEALEVGLERIWKTLQEVEASGWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7L2</accession>
    <name>G0S7L2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0036720</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694099.1">
        <property type="nucleotide sequence ID" value="XM_006694036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7L2"/>
    <dbReference type="STRING" id="759272.G0S7L2"/>
    <dbReference type="GeneID" id="18257710"/>
    <dbReference type="KEGG" id="cthr:CTHT_0036720"/>
    <dbReference type="eggNOG" id="ENOG502SACR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_401694_0_0_1"/>
    <dbReference type="OMA" id="MACTIEN"/>
    <dbReference type="OrthoDB" id="3545073at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS21803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="685" mass="75210" checksum="02AC506106B071A7" modified="2011-10-19" version="1">MDALTPANATASSRQNATPSVKPIYKMKRTGTASLPGSLPSSSGTGSARLSATNRTIGTSISSTALPQPVSDAKPEPAKIVSDILPSASTPGVTTASVTPKSMPSSSGYKPKYATDEERRKAISQALKQRWASGRMDHVHKKRVETLRRRRKEAALTKFLAVSGTKLRSSPSDPKLLHRSAPTNSSHKQQFLASDPFDRFLDDQSSEPDFYLDEPSPGSPSQFDDDSTTTGTASGRNDAHWSLELWKYLQPHLIKHKGPVPPKTGWVRQLLPLPRVRDLDWNEAWLVEHPFLDSKPRDVSALIIQVTGELAPQPCRQRADNILRNRIRPIGSQDDSLGGTGSDEECIDKMETDNALDEVPSKGEEFRAALTQAEPGRPYNMWPVDRTGQLFKLPGTTLLPAGYKLDSTFPGRPWICPVRTCRKVFPKTADLAYHFERIHFATCLNDNGDGTFTVKGTYLSKHDSIGKGGKILHPAPPIVVSKEPIKDGLPLPKPQLPTYLANNRSFNEVAEESNYADNEQDQSPPYSLRPRVHQNASFTTQLSRSQSTSALISRGSFEMSGDILEMEDWEIAPGRIKDSSTTNGQSIAYSKAFLETSKAVPVCDDVFFRVDTIPPGGVLRLEPEEAQMRLCSIAAGKVQVKLGDVGEFLLGPHGMFKVKPGVECHVTNRLYLDAVLHTTLLQGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7U9</accession>
    <name>G0S7U9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0028890</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693345.1">
        <property type="nucleotide sequence ID" value="XM_006693282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7U9"/>
    <dbReference type="STRING" id="759272.G0S7U9"/>
    <dbReference type="GeneID" id="18256927"/>
    <dbReference type="KEGG" id="cthr:CTHT_0028890"/>
    <dbReference type="eggNOG" id="KOG1867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008279_6_0_1"/>
    <dbReference type="OMA" id="NRDNSCY"/>
    <dbReference type="OrthoDB" id="2020758at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02662">
        <property type="entry name" value="Peptidase_C19F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF888">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="10">
        <location>
            <begin position="151"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="543"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="648"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="655"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS21049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="742" mass="82327" checksum="8C04ADC26CE973BA" modified="2011-10-19" version="1">MTFTDLSAVQHGPDRRQFTLSNGYHHAFPGQAREKPFAVTVLFSAIIVVAISAVVFAGELPRQLELLLERLLDFILHFIPAWLLFAIDRWANPPSDEDAMRKPLLPASTHVAKREAMWRLLGLDKGRGLLQPVTQSFQLFHRPPDPNAPPPGLVNMDNSCFQNSILQALASLEPLHKYISDVADETKTRRVPPPKTVLSLHQLMSDLTNPDKNGNTFWAPGPLKNMNTWQQQDAQEYYSRLLDEVEKEVVKTGFGRRKDSASLTPSPRRGSSPISQGSDQDSGYFSASSLSTCDWEAGARMPLEGYIAQRVACVQCGYCEGLSITPFNFLTLSLEDFLEHDVRERLDHYTKIEEIEGVECVKCTLLALRDNIKSMQERTPSLPGLSERLQTVEDVLEQETFDDEAIKRCKIPPKKRVTTTKTKQMAIARAPQCLVLHMNRSVFDERTGRLLKNLARVHFPKLLDLGPWCLGSIGPHTMLKKGAPAEQDEEQWPLGPTETMVAGGAPGKSRIQGPLYELRAVVAHHGNHNNGHYVCFRQHPIAPKPKGNGVEKGETPMTSAPDEADQDDDDYPKLDGVKEMFDGETLSLPSEEQEPSNEPEPQWWRFSDEDVRPVSEKMVLDGSNVFMLFYDCIDARSVVKPPLSVISTTDDDVVSTPSLSEGETLDLTNTPTSSAASSSTEMPPHNAASTPATSFISATTSDELLDAANQLDLDNPVVRALLLNKAREFSLGESANGEYPDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7Y3</accession>
    <name>G0S7Y3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino acid permease-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0037430</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694166.1">
        <property type="nucleotide sequence ID" value="XM_006694103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7Y3"/>
    <dbReference type="GeneID" id="18257781"/>
    <dbReference type="KEGG" id="cthr:CTHT_0037430"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_12_1_1"/>
    <dbReference type="OMA" id="WRILFVY"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000001">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF26">
        <property type="entry name" value="GENERAL AMINO ACID PERMEASE AGP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="48"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS21870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="539" mass="58895" checksum="9D29077D937EF308" modified="2011-10-19" version="1">MLFPLKGDTQPSKAKDDEAVIASNGSDSDDFREIDPNSGVKRGLKTRHLSMMALAGIIGPGLLVGSGGALSSGGPASLLIGFGVIGIVAFSIMQSLGELTTLYPTGGAFTSLSDRFVDKAFGVAVGWNYFIIWFCVLANEYNVISSIMTFWSEKVPIWGYFLIFWFAFLAFQLLGVETFGEAEFWLALIKIVGLIAYFFFSIIYASGGVKGAPAIGFKYWHDPGAFADGFRGVASVFVFCSTFYAGVEAVAVAATETRNPGRAVPLAIRQVFIRIIVVYMGSAFFFGLTCPSNAEGLIGGAQRALRSPMTIAIQNAGWQSGVHLINAFIFITTLSAINSSIYIASRTILFMAQDGKAPKFFGWTDKRGVPIPAIVFTNLCGALSMMNVSTGASKAYSYIVNLSGVSTFLVWGAISFTHIRFRSAWKAQGYSESDLPFVSLWYPWNAYFGLASNIFLALIQGWKTLAPFSAGDFVDAYILLPLFGVIYVVYKFVFKTKFWSSLEVDLQSGRRKDLDSAKYAQKAQDVESLPWWKKAWKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8C4</accession>
    <name>G0S8C4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0021240</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2017" name="Nat. Struct. Mol. Biol." volume="24" first="954" last="964">
            <title>3.2-A-resolution structure of the 90S preribosome before A1 pre-rRNA cleavage.</title>
            <authorList>
                <person name="Cheng J."/>
                <person name="Kellner N."/>
                <person name="Berninghausen O."/>
                <person name="Hurt E."/>
                <person name="Beckmann R."/>
            </authorList>
            <dbReference type="PubMed" id="28967883"/>
            <dbReference type="DOI" id="10.1038/nsmb.3476"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.20 ANGSTROMS)</scope>
    </reference>
    <reference evidence="9 10 11" key="3">
        <citation type="journal article" date="2019" name="Mol. Cell" volume="75" first="1256" last="1269.e7">
            <title>Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration.</title>
            <authorList>
                <person name="Cheng J."/>
                <person name="Bassler J."/>
                <person name="Fischer P."/>
                <person name="Lau B."/>
                <person name="Kellner N."/>
                <person name="Kunze R."/>
                <person name="Griesel S."/>
                <person name="Kallas M."/>
                <person name="Berninghausen O."/>
                <person name="Strauss D."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="31378463"/>
            <dbReference type="DOI" id="10.1016/j.molcel.2019.06.032"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.50 ANGSTROMS)</scope>
    </reference>
    <reference evidence="12 13" key="4">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="476" last="476">
            <title>High-resolution structures of a thermophilic eukaryotic 80S ribosome reveal atomistic details of translocation.</title>
            <authorList>
                <person name="Kisonaite M."/>
                <person name="Wild K."/>
                <person name="Lapouge K."/>
                <person name="Ruppert T."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="35079002"/>
            <dbReference type="DOI" id="10.1038/s41467-022-27967-9"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.90 ANGSTROMS)</scope>
    </reference>
    <reference evidence="14 15" key="5">
        <citation type="journal article" date="2023" name="Nat. Struct. Mol. Biol." volume="30" first="670" last="677">
            <title>Structural inventory of cotranslational protein folding by the eukaryotic RAC complex.</title>
            <authorList>
                <person name="Kisonaite M."/>
                <person name="Wild K."/>
                <person name="Lapouge K."/>
                <person name="Gese G.V."/>
                <person name="Kellner N."/>
                <person name="Hurt E."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="37081320"/>
            <dbReference type="DOI" id="10.1038/s41594-023-00973-1"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.20 ANGSTROMS)</scope>
    </reference>
    <reference evidence="16" key="6">
        <citation type="journal article" date="2024" name="Nat. Commun." volume="15" first="716" last="716">
            <title>Methionine aminopeptidase 2 and its autoproteolysis product have different binding sites on the ribosome.</title>
            <authorList>
                <person name="Klein M.A."/>
                <person name="Wild K."/>
                <person name="Kisonaite M."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="38267453"/>
            <dbReference type="DOI" id="10.1038/s41467-024-44862-7"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.10 ANGSTROMS)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692595.1">
        <property type="nucleotide sequence ID" value="XM_006692532.1"/>
    </dbReference>
    <dbReference type="PDB" id="5OQL">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="p=1-203"/>
    </dbReference>
    <dbReference type="PDB" id="6RXT">
        <property type="method" value="EM"/>
        <property type="resolution" value="7.00 A"/>
        <property type="chains" value="Ce=1-203"/>
    </dbReference>
    <dbReference type="PDB" id="6RXU">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.50 A"/>
        <property type="chains" value="Ce=1-203"/>
    </dbReference>
    <dbReference type="PDB" id="6RXV">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.00 A"/>
        <property type="chains" value="Ce=1-203"/>
    </dbReference>
    <dbReference type="PDB" id="6RXX">
        <property type="method" value="EM"/>
        <property type="resolution" value="7.10 A"/>
        <property type="chains" value="Ce=1-203"/>
    </dbReference>
    <dbReference type="PDB" id="6RXY">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.70 A"/>
        <property type="chains" value="Ce=1-203"/>
    </dbReference>
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        <property type="method" value="EM"/>
        <property type="resolution" value="4.40 A"/>
        <property type="chains" value="Ce=1-203"/>
    </dbReference>
    <dbReference type="PDB" id="7OLC">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="SH=1-203"/>
    </dbReference>
    <dbReference type="PDB" id="7OLD">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="SH=1-203"/>
    </dbReference>
    <dbReference type="PDB" id="7Z3N">
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        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="SH=1-203"/>
    </dbReference>
    <dbReference type="PDB" id="7Z3O">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.30 A"/>
        <property type="chains" value="SH=1-203"/>
    </dbReference>
    <dbReference type="PDB" id="8OO0">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="SH=1-203"/>
    </dbReference>
    <dbReference type="PDBsum" id="5OQL"/>
    <dbReference type="PDBsum" id="6RXT"/>
    <dbReference type="PDBsum" id="6RXU"/>
    <dbReference type="PDBsum" id="6RXV"/>
    <dbReference type="PDBsum" id="6RXX"/>
    <dbReference type="PDBsum" id="6RXY"/>
    <dbReference type="PDBsum" id="6RXZ"/>
    <dbReference type="AlphaFoldDB" id="G0S8C4"/>
    <dbReference type="EMDB" id="EMD-10051"/>
    <dbReference type="EMDB" id="EMD-10052"/>
    <dbReference type="EMDB" id="EMD-10053"/>
    <dbReference type="EMDB" id="EMD-10054"/>
    <dbReference type="EMDB" id="EMD-10055"/>
    <dbReference type="EMDB" id="EMD-10056"/>
    <dbReference type="EMDB" id="EMD-12976"/>
    <dbReference type="EMDB" id="EMD-12977"/>
    <dbReference type="EMDB" id="EMD-14479"/>
    <dbReference type="EMDB" id="EMD-14480"/>
    <dbReference type="EMDB" id="EMD-17004"/>
    <dbReference type="EMDB" id="EMD-3847"/>
    <dbReference type="SMR" id="G0S8C4"/>
    <dbReference type="IntAct" id="G0S8C4">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S8C4"/>
    <dbReference type="GeneID" id="18256162"/>
    <dbReference type="KEGG" id="cthr:CTHT_0021240"/>
    <dbReference type="eggNOG" id="KOG3320">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088621_1_2_1"/>
    <dbReference type="OMA" id="AAYHKVQ"/>
    <dbReference type="OrthoDB" id="1724687at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000554">
        <property type="entry name" value="Ribosomal_eS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047861">
        <property type="entry name" value="Ribosomal_eS7_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01251">
        <property type="entry name" value="Ribosomal_S7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00948">
        <property type="entry name" value="RIBOSOMAL_S7E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8 9 10" id="KW-0002">3D-structure</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS20299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="5OQL"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="6RXT"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="6RXU"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="6RXV"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="7OLC"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="7OLD"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="7Z3N"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="7Z3O"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="8OO0"/>
        </source>
    </evidence>
    <sequence length="203" mass="23043" checksum="5867B7D3E8D82120" modified="2011-10-19" version="1">MSAPSLNKIAANSPSRQNPSDLERAIAGALYDLETNTADLKAALRPLQFVSAREIEVGHGKKAIVIFVPVPALQGFHRVQQRLTRELEKKFSDRHVLILAARRILPKPKRSARSRNTLKQKRPRSRTLTAVHDAILTDLVYPVEIVGKRLRTKEDGSKVLKVILDEKERGGVDYRLDTYSEVYRRLTGRNVTFEFPQTTITDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8Y1</accession>
    <name>G0S8Y1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7820 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0043840</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694777.1">
        <property type="nucleotide sequence ID" value="XM_006694714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8Y1"/>
    <dbReference type="STRING" id="759272.G0S8Y1"/>
    <dbReference type="GeneID" id="18258422"/>
    <dbReference type="KEGG" id="cthr:CTHT_0043840"/>
    <dbReference type="eggNOG" id="ENOG502SJP0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011816_0_0_1"/>
    <dbReference type="OMA" id="YAMYPQN"/>
    <dbReference type="OrthoDB" id="5384459at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056722">
        <property type="entry name" value="DUF7820"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42078">
        <property type="entry name" value="GLUCAN 1, 4-ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42078:SF1">
        <property type="entry name" value="GLUCAN 1, 4-ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25130">
        <property type="entry name" value="DUF7820"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="392"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7820" evidence="3">
        <location>
            <begin position="435"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7820" evidence="3">
        <location>
            <begin position="755"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="686"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="705"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS19892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="950" mass="104281" checksum="D953BB29418BE364" modified="2011-10-19" version="1">MDSKEGKTPGDLDRRASTRSSVRYSVSVSNNELDEDYDALAANGLVADGFHPPQTPSQHLQDSGDSTPSRPPSSPATTTSTSTTTGTLVGEDSLDRNRPSSVSKHRPRMSSLSTTHEQDEYQQRLSRHASVSTDSTSRMVLPIDSPYQGPVRPSHPYQMYPQTVRGPRSMSMTTTSSSIPPAVIETPYTGPRGPSHPYSLYPQGTGIDLMVAPNAAIPIGFHGLPDQYHRRIGPDGDDLGDIIGPDGHTEQLPPYTRYPEEVYLRKGPLPDEEPPGPEVVCGPPPLPPPPPLLSGATVLPTGAMNAPQVPRSGTPVIPGAGGIGLATRNPEFESTDDDLGSPRSRHSSRSFGSDESHGRFRANDESERLNEKTGETRPQRWLKRKMCGVIPYWAICLTVLILVVMAVVMSTVMGIFLTREKKRGLKNKQPQWDPNFDAIPIAPPPDLQPLPLGTYSMPLINTRSSNTCFQNTTLAQAWNCRLIMVGLQLTISKEGDDYKASLDCNHSYTIMNHVYAYGEQPPLIQEPVKLQLVKDKFEMNRGPAWFKILSYNKTVILPENWLLNPMSGGTDEFVEKRSLVGVEKRYLGGGGGGFDPPFGDLNKRKGVAQAGDRPWICTWPETYLELFIYAQQNSSTPSWSKPFSGSISGPRFPTGTVPPFEQTPSVTTMTVTTTADIGFETEASSDVLPETEHQQEQQTPPPFNNSPTPTSTPEQSTFHPNKNDRPENNDNNNSPPPNNPRRNRPRGMGAYQHDMTTTTTATTSPDTTPPPTILPTDFPEEDRPGFGFDFDRDSFIPPPPPYPRVIKLAERRVSTQGAPRARCTQVAIMGPRQKAEPVRDHKGSEVVIEVMETETFFGFGGGDLKKKKGDGDGTGETMTVTAKSAQEMGITGEAEEKREVPVVVMPRGWEEMYGGRGYTEEDEVEVEGWGLEKRNGVPDISPCGCMWFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0S964</accession>
    <name>G0S964_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Amine oxidase</fullName>
            <ecNumber evidence="15">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CTHT_0044710</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a primary methyl amine + O2 + H2O = an aldehyde + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16153"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:228804"/>
            <dbReference type="EC" id="1.4.3.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="15">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="14">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="14 15">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="15"/>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694860.1">
        <property type="nucleotide sequence ID" value="XM_006694797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S964"/>
    <dbReference type="STRING" id="759272.G0S964"/>
    <dbReference type="GeneID" id="18258509"/>
    <dbReference type="KEGG" id="cthr:CTHT_0044710"/>
    <dbReference type="eggNOG" id="KOG1186">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011500_3_2_1"/>
    <dbReference type="OMA" id="VHVGFNY"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000019">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000014">
        <property type="entry name" value="Peroxisomal primary amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049947">
        <property type="entry name" value="Cu_Am_Ox_Cu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015802">
        <property type="entry name" value="Cu_amine_oxidase_N3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008559">
        <property type="entry name" value="PRK11504.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF86">
        <property type="entry name" value="COPPER AMINE OXIDASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02728">
        <property type="entry name" value="Cu_amine_oxidN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01165">
        <property type="entry name" value="COPPER_AMINE_OXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13 15" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="17">
        <location>
            <begin position="8"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase N3-terminal" evidence="18">
        <location>
            <begin position="99"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="16">
        <location>
            <begin position="228"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="13">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="14">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGS19975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="698" mass="79151" checksum="384E2826A01897D2" modified="2011-10-19" version="1">MTINIIPHPFDPLSAAEIEQAISIVKKAHGNDLFFNIVSLQEPRKAEMTAWLQAPETAPRPKRVAEVVVIAQDGKVFDGLVDLTSGTITKWDLLDGEQPIITMEELQLVEHVVRTDPKVIEQCVISGIDPKDMDKVYCDPWTIGYDKRFGSKKRYQQALMYYRPDIDDCQYQYPLDFCPIYDAEQKKIVHIDIPEVRRPLSRVPPVNYHPAGVEKKGGYRTDLKPIYITQPEGVSFKMTGRWMEWQNWKFHIGFNYREGIVFNNITFNDHGVERPIFYRLSLAEMVVPYGNPEHPHQRKHALDQGEYGAGYMTNSLSLGCDCKGAIHYLDADFPTRAGGVRTIKNAICIHEEDNGILFKHSDFRDDSVIVTRARKLIIQQIFTAANYEYAVAWIFHQDGTIQPEVKLTGILNTYSMDPDEDTKGWGTQVYPGVNAHNHQHLFCLRIDANVDGPKNTVFVNDAVPSDAPVGSPENPYGNAFYCKRTKLVTPAQAKTDYDGSTSRSWEIANTNKLHPYSKKPVSYKLVSREVPGLLPKPGSLVWKRAPFARHAVWVTKYRDDQLYPAGRHVPQTSGEKPVGIDAWLSEPGVADENIDNEDIVLWHTFGLTHFPAPEDFPVMPAEPITLLLRPRNFFENNPVMDVPFSYCRVPSQVRDGVPGWDKYRLVDRISKLAFDEGKEDGEKKEKEVNGCKGGCCGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9F2</accession>
    <name>G0S9F2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mandelate racemase/muconate lactonizing enzyme C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0045650</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694948.1">
        <property type="nucleotide sequence ID" value="XM_006694885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9F2"/>
    <dbReference type="STRING" id="759272.G0S9F2"/>
    <dbReference type="GeneID" id="18258603"/>
    <dbReference type="KEGG" id="cthr:CTHT_0045650"/>
    <dbReference type="eggNOG" id="ENOG502QRKX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030273_1_1_1"/>
    <dbReference type="OMA" id="WGYAELR"/>
    <dbReference type="OrthoDB" id="17395at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050032">
        <property type="term" value="F:L-rhamnonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03327">
        <property type="entry name" value="MR_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000005">
        <property type="entry name" value="Putative L-rhamnonate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023444">
        <property type="entry name" value="L-Rhamnon_dehydrat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046945">
        <property type="entry name" value="RHMD-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011968">
        <property type="entry name" value="PRK15440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794">
        <property type="entry name" value="ENOLASE SUPERFAMILY, MANDELATE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794:SF58">
        <property type="entry name" value="MITOCHONDRIAL ENOLASE SUPERFAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00179">
        <property type="entry name" value="mandelate_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00006">
        <property type="entry name" value="rhamnonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="5">
        <location>
            <begin position="170"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS20063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="427" mass="47252" checksum="99CE7950F8EBEB12" modified="2011-10-19" version="1">MPGLRSFPTIKTVHSYVIQGVGSGGDYHNVAGGHWLVDSPISTPCSRWEKYRTSRTSWGINVLGSFFVEIEASDGTVGFATGFGGPPACWLIHQHFERFLIGADPRNTNIIFEQMYRASMFYGRKGLPVAVISVIDLAIWDLLGKLRGEPVYKMIGGASRDRINFYCTTPDSAAAKAMGFWGAKVPLPYCPEEGPEGLKKNVEFLRKHREAVGPDFPLMVDCYMSLNVPYTIELAKACLDLNIHWWEECLSPDDTEGFALLKRAHPTLRFTTGEHEYSRYGFRKLIEGRNVDILQPDVMWVGGMTELLKIAAMAAAYDIPVVPHASGPYSYHFVVSQPNTPFQEYLANSPDGKSVFPVFGDLFLDEPIPTKGFLTTADLDKPGFGLTVNPTARAKLIQLGDTSLSAIPPAPHIPNGHARNHEDKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G0SA68</accession>
    <name>G0SA68_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Nitrite reductase [NAD(P)H]</fullName>
            <ecNumber evidence="19">1.7.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CTHT_0041190</name>
    </gene>
    <organism evidence="24">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>NH4(+) + 3 NAD(+) + 2 H2O = nitrite + 3 NADH + 5 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24628"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.7.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>NH4(+) + 3 NADP(+) + 2 H2O = nitrite + 3 NADPH + 5 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24632"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.7.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>siroheme</name>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism; nitrate reduction (assimilation).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.</text>
    </comment>
    <dbReference type="EC" id="1.7.1.4" evidence="19"/>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694525.1">
        <property type="nucleotide sequence ID" value="XM_006694462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SA68"/>
    <dbReference type="STRING" id="759272.G0SA68"/>
    <dbReference type="GeneID" id="18258157"/>
    <dbReference type="KEGG" id="cthr:CTHT_0041190"/>
    <dbReference type="eggNOG" id="KOG1336">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003291_0_0_1"/>
    <dbReference type="OMA" id="MWGGVTN"/>
    <dbReference type="OrthoDB" id="432169at2759"/>
    <dbReference type="UniPathway" id="UPA00653"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008942">
        <property type="term" value="F:nitrite reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015980">
        <property type="term" value="P:energy derivation by oxidation of organic compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd19943">
        <property type="entry name" value="NirB_Fer2_BFD-like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19944">
        <property type="entry name" value="NirB_Fer2_BFD-like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03529">
        <property type="entry name" value="Rieske_NirD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000007">
        <property type="entry name" value="Nitrite reductase [NAD(P)H] large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1100:FF:000002">
        <property type="entry name" value="Nitrite reductase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.480.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="entry name" value="BFD-like [2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="entry name" value="Sulfite Reductase Hemoprotein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
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    <dbReference type="InterPro" id="IPR052034">
        <property type="entry name" value="NasD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
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        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012748">
        <property type="entry name" value="Rieske-like_NirD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02378">
        <property type="entry name" value="nirD_assim_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011565">
        <property type="entry name" value="PRK14989.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43809">
        <property type="entry name" value="NITRITE REDUCTASE (NADH) LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43809:SF1">
        <property type="entry name" value="NITRITE REDUCTASE (NADH) LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FADPNR"/>
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        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Nitrite/Sulfite reductase N-terminal domain-like"/>
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    </dbReference>
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        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="976"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="863"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="865"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="911"/>
            <end position="940"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001929"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005096"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00050114"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00051413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00066907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00070300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EGS19640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1177" mass="127806" checksum="A11651FA3A54F4D6" modified="2011-10-19" version="1">MAVMPQSQKTIVVVGLGMVGISFIEKLLKLDVRTRQYNIIVFGEEPHVAYNRVGLTTFFEHRKVENLYLNPAEWYTSIPDNALTYHISTPVTAINPISKTITTSTGTTVPYDILVLATGSNAALPRNTPGIDARGVFVYRTVADLEALITHSQQLLPSQDQEKVGAVVGGGLLGLEAAKALLDLQTYDRVVVVERNGWVLARQLDGDAGALVVEKVRQLGVEVLLEKRVACVETDEGINVTGLRFEDGTALRCQTVVFATGIRPRDELARTAGLAVSESGGIVVDSQLRTSTRDVYAIGECASWEGQTFGLIAPGVEMADVLAWNLTQAAEHGGQERSFSQPDLSTKLKLLGVEVASFGDYFADRDGPRRLPEQRGRKKGETGTTCNNTKVKALTYRDPFQHIYKKYIFTSDGKYLLGGMMIGDTQDYVKLVPLAKNLKPLDTPPAELILGSSSKKDSDGTDDLPDDTQVCSCHNVTKGAIVSAVRDGTATTLSTLKSCTKAGTGCGGCMPLVTTIFNKTMASLGNAVSNHICAHIPRSRAELYHIVMVKQLKTFAEVMTAAGTDPQSMGCEICKPAVGSILSSLWNGHVMSRPLHGLQDTNDRFLANIQRDGSFSVVPRVPGGEITPEKLIVLGEVAREYGLYTKITGGQRIDLFGARKQDLPAIWKKLVDAGMESGHAYAKALRTVKSCVGSTWCRYGIGDSVGMAIRLEERYKSIRAPHKIKGGVSGCVRECAEAQSKDFGLIATDKGFNIYVGGNGGAKPRHAELLAKDVPPTEVIPILDRYLMFYIRTADRLQRTARWIESLPGGINYLRDVVLKDSLGLAAELESQMQDLVDSYFDEWAEAVKDPELAAKFAQFSNAKDGQDTVEREDERGQKRPAWWPKQAVTTTTTTIAVSQSDAARGEEARSSVSDSSSDSATLKSSSSSDSLSSATTVSTSPPPSSDSLEPPNQIPFSSLRTHWSSTTWMPLIPASHFDGADDLPNGISATIRVSDTQLAIFRVRGRYYATQQMCPHKRAFVLSDSLVGTNPPSEEKQEGEVYIACPHHKTPFSLPTGACLTSTGNNPNESMSIATFDVEEREDGMVYVKLPPLDELDAALGTSRWIVRRGETGAAQLEEMDQKFGGFGDGRWKRPAAVVRGRARKPELRQKKEKDEKGVEMIVEGGCGGCGGTPDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAB4</accession>
    <name>G0SAB4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0041670</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694571.1">
        <property type="nucleotide sequence ID" value="XM_006694508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAB4"/>
    <dbReference type="GeneID" id="18258205"/>
    <dbReference type="KEGG" id="cthr:CTHT_0041670"/>
    <dbReference type="HOGENOM" id="CLU_2096606_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="116" mass="12606" checksum="0A72B646F8778C38" modified="2011-10-19" version="1">MDSHTWRPLSALKQVLTFAGDVGCQTSAVTPNHWPRLPQVIAVKVCPLTIAIVFFNITLRVFEAFALISRRLETVSSLVERRQAELALGQTFRGVSESVFGKTATLLPKIAPAGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAS5</accession>
    <name>G0SAS5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0043320</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694732.1">
        <property type="nucleotide sequence ID" value="XM_006694669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAS5"/>
    <dbReference type="GeneID" id="18258370"/>
    <dbReference type="KEGG" id="cthr:CTHT_0043320"/>
    <dbReference type="eggNOG" id="ENOG502SYX6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_288542_0_0_1"/>
    <dbReference type="OMA" id="RFMACAD"/>
    <dbReference type="OrthoDB" id="2149705at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="699"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="917"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="699"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="713"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="918"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="934"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="988"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1015"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1081"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1108"/>
            <end position="1124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1145" mass="124826" checksum="C525AC95980767F1" modified="2011-10-19" version="1">MPPRKKSAASSSTSATSTSTTNKNNAPASRTYRSAPVPKQVYFPPRRKMVRTYGRKGRRSLPAELEGGGIGIADDEGKEENGPMTRRRSLRQATLTQVGYVRSSSGLGEEDEGRGELRVSDEEDNMEEVMEEAETGKSGAPRGKGSGSTKMGKKGVRFAEGKEEKKARTRRRRTTGDLPSWSESKASTFHTQTLTQLLSTMPDSSRDTLRLDDDDDNDPDRPKNRRKRRSPQPPLATSSHTPGTTDPHTPSAKRIRVSLDEVPCSQPTPLTPMLDRYSPLVPGAVRSPLTQKSTNVGVAIPESVAQGRGKRPRTLVVQDSYASMLSESEPEAEGPVGPGASGKHEEKKEESQRIPLAEIPLERLDEIRGKGKASQRVPLSEIPVESLECVGVARRSQSQRVPLAEIPVESLAPAAAGQGTQSQRVPLAEIPVESLAAGGAEDGMTPTTRRVLGSAGRGRYVEIPDSDDDGLSLGSTPFSRTQRTPLAPNIGQGFEVLADSGSSRSGRNDPQPPGSVRSMRSDKENSGPLEEMRAPREIHDSEDESDDEIPGTPTPASRRAMRLSQGAGSRSVIKASSELGSRSPKLATSQRMQSNEPVPETPTPAARMATPVVEERVSEEDDEEATASESEEKEQGTPVRAVKKPTPQVLTSTRKSALKAPGTPTPAVRRVQIELPPTSASRHGNNNNNNNNNNNVAKEEAEEAYKETPRRPQAQQTVKSSPLYARQTQRSQYFSQLESQRVPLEVIRSLGPQTDRSDILIAIPDKIVDEIVQGLRDHEFRPYRFPTQVCRVWIYTVPNGREDEGEVKYMATLGPAKEPGEIDSRTGLGNAEFNMRKSPEMRFAHKLKQVYRLNNPLPAKDMPDNGLGRGAPLRWRYVPPAIVGQLLGNLRCPLFEEEDENAIRVEDDDRDVAGGTVSQQLEEQLLSDLVGSTKRGDKSKEREIEREEEDVIPASQSPLAPRASRKGRGHRGQQDQQPKVGTGRARPSIQTSSSNFVRPSQATTASEASEDPSLSSPPPAAARMLPPPRNARTRANANRPRQVHVLSSETNEPSPRKDNGQDPTVDDEEEPTPTPFPRPQHPLSSSQPALSLPAYHDGSGENEGGSLGVELPLVESSSLPPDSLLIDRGREAPEPILWDSDEEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAV3</accession>
    <name>G0SAV3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0047900</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695155.1">
        <property type="nucleotide sequence ID" value="XM_006695092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAV3"/>
    <dbReference type="STRING" id="759272.G0SAV3"/>
    <dbReference type="GeneID" id="18258828"/>
    <dbReference type="KEGG" id="cthr:CTHT_0047900"/>
    <dbReference type="eggNOG" id="ENOG502S522">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109915_3_1_1"/>
    <dbReference type="OMA" id="ITTIFWF"/>
    <dbReference type="OrthoDB" id="2117453at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451">
        <property type="entry name" value="MARVEL DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="6">
        <location>
            <begin position="13"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS19333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="145" mass="16204" checksum="8EE84B4DC93EC6C6" modified="2011-10-19" version="1">MTSLNRYVPYVLAVSALFCVIELGLTAYIVSPWGAPSSMEFMLFNSVWTLLVLAYIGLVPMYVSRYYHRQAGLALKWITTIFWFAGSIALAAFWGAPRCYGNNYCNTVEAACAFGFFLWLLFSFITFVDTVDYLRGAKAQPAAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAZ2</accession>
    <name>G0SAZ2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tetratricopeptide repeat and J domain-containing co-chaperone DNJ1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0048310</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695194.1">
        <property type="nucleotide sequence ID" value="XM_006695131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAZ2"/>
    <dbReference type="SMR" id="G0SAZ2"/>
    <dbReference type="STRING" id="759272.G0SAZ2"/>
    <dbReference type="GeneID" id="18258869"/>
    <dbReference type="KEGG" id="cthr:CTHT_0048310"/>
    <dbReference type="eggNOG" id="KOG0624">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015935_0_1_1"/>
    <dbReference type="OMA" id="PFAHFQH"/>
    <dbReference type="OrthoDB" id="1726119at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000083">
        <property type="entry name" value="DnaJ and TPR domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000224">
        <property type="entry name" value="DnaJ and TPR domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051727">
        <property type="entry name" value="DnaJ_C3_Co-chaperones"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140:SF2">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408969" description="Tetratricopeptide repeat and J domain-containing co-chaperone DNJ1" evidence="9">
        <location>
            <begin position="24"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="69"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="10">
        <location>
            <begin position="403"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="466"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="466"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS19372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="526" mass="57726" checksum="4247115E8C3D8CB4" modified="2011-10-19" version="1">MLVSLSALAFAAGILSTPSLVNGLSPADIPADTPVSRLLASAQAHLSKGETNDALVYYDAAVAKDPTNYLTFFKRATTYLSLGRTAQAADDFEKVLKLKPGFEGAHVQLGKLKARTGDWDAAKAHYKKAKKTEEIAKVDGAKSAQKQAEKAAKAEKWEDCIKHADDAIVVANRALSLRQLRAKCALEGGSLDRAIGDLQHVLQMSPGNTAPHVMISAIQFYGMGDLQDGMSSIRKCLHSDPDSKVCKRLLRDEKAVEKAVQKISKALEKNQYMTAVRQLVPSADDEGLISEVKKQVQALRDEGHLPKRAGNALLSRLVEMACQAYYESNSKKAKDYCDESLKLDENSFYGLLYRAKQLQEEEEYEAAINTLRKAAEARPGKEDIINPLMQKAQIALKRSKSKDYYKVLGVPHDADERQIKSAYRKLSKQYHPDKAAKQGLTKEQAEKKMAAINEAYEVLSNPELRARFDRGDDPNNHEQPPPFQGNPFGHGHPFMFHQGGPGGGGFQFKFGSGFPFGGPFGAQFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0SB32</accession>
    <name>G0SB32_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Zinc finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0048710</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="15 16 17" key="2">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e57984" last="e57984">
            <title>Structural insights into coordinating 5S RNP rotation with ITS2 pre-RNA processing during ribosome formation.</title>
            <authorList>
                <person name="Thoms M."/>
                <person name="Lau B."/>
                <person name="Cheng J."/>
                <person name="Fromm L."/>
                <person name="Denk T."/>
                <person name="Kellner N."/>
                <person name="Flemming D."/>
                <person name="Fischer P."/>
                <person name="Falquet L."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="37921038"/>
            <dbReference type="DOI" id="10.15252/embr.202357984"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.12 ANGSTROMS) IN COMPLEX WITH ZN(2+)</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695234.1">
        <property type="nucleotide sequence ID" value="XM_006695171.1"/>
    </dbReference>
    <dbReference type="PDB" id="8PV1">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.56 A"/>
        <property type="chains" value="Cb=1-117"/>
    </dbReference>
    <dbReference type="PDB" id="8PV2">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.63 A"/>
        <property type="chains" value="Cb=1-117"/>
    </dbReference>
    <dbReference type="PDB" id="8PV3">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="Cb=1-117"/>
    </dbReference>
    <dbReference type="PDB" id="8PV4">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="Cb=1-117"/>
    </dbReference>
    <dbReference type="PDB" id="8PV5">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.86 A"/>
        <property type="chains" value="Cb=1-117"/>
    </dbReference>
    <dbReference type="PDB" id="8PV6">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.94 A"/>
        <property type="chains" value="Cb=1-117"/>
    </dbReference>
    <dbReference type="PDB" id="8PV7">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.12 A"/>
        <property type="chains" value="Cb=1-117"/>
    </dbReference>
    <dbReference type="PDB" id="8PV8">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.91 A"/>
        <property type="chains" value="Cb=1-117"/>
    </dbReference>
    <dbReference type="PDB" id="8PVK">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.55 A"/>
        <property type="chains" value="Cb=1-117"/>
    </dbReference>
    <dbReference type="PDB" id="8PVL">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.19 A"/>
        <property type="chains" value="Cb=1-117"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SB32"/>
    <dbReference type="EMDB" id="EMD-17950"/>
    <dbReference type="EMDB" id="EMD-17951"/>
    <dbReference type="EMDB" id="EMD-17952"/>
    <dbReference type="EMDB" id="EMD-17953"/>
    <dbReference type="EMDB" id="EMD-17954"/>
    <dbReference type="EMDB" id="EMD-17955"/>
    <dbReference type="EMDB" id="EMD-17956"/>
    <dbReference type="EMDB" id="EMD-17957"/>
    <dbReference type="EMDB" id="EMD-17969"/>
    <dbReference type="EMDB" id="EMD-17970"/>
    <dbReference type="SMR" id="G0SB32"/>
    <dbReference type="STRING" id="759272.G0SB32"/>
    <dbReference type="GeneID" id="18258909"/>
    <dbReference type="KEGG" id="cthr:CTHT_0048710"/>
    <dbReference type="eggNOG" id="KOG3408">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117291_2_2_1"/>
    <dbReference type="OMA" id="MKDHFRS"/>
    <dbReference type="OrthoDB" id="24683at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000299">
        <property type="entry name" value="Zinc finger protein 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051879">
        <property type="entry name" value="C2H2-ZF_Maturation_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="15 16 17" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7 15 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15 16 17">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15 16 17">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15 16 17">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS19412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="8PV1"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="8PV2"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PDB" id="8PV3"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PDB" id="8PV7"/>
        </source>
    </evidence>
    <sequence length="117" mass="13682" checksum="2A1854CA21158DEB" modified="2011-10-19" version="1">MGVFAKRTMTKTRRRLRDLDQIERDLRSPRHLQQYKETKAAEDLPGLGLYYCIECAKWFESETSLVGHRKGKPHKRRLKQLKEGAYTHEEAMAAIGYRIDNGKKTTEQPKTQDVEMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G0SB67</accession>
    <name>G0SB67_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arginase</fullName>
            <ecNumber evidence="3">3.5.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0049080</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-arginine + H2O = urea + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:20569"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="EC" id="3.5.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.1" evidence="3"/>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695269.1">
        <property type="nucleotide sequence ID" value="XM_006695206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SB67"/>
    <dbReference type="STRING" id="759272.G0SB67"/>
    <dbReference type="GeneID" id="18258946"/>
    <dbReference type="KEGG" id="cthr:CTHT_0049080"/>
    <dbReference type="eggNOG" id="KOG2965">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_514928_0_0_1"/>
    <dbReference type="OMA" id="IHIHIRH"/>
    <dbReference type="OrthoDB" id="9992747at2759"/>
    <dbReference type="UniPathway" id="UPA00158">
        <property type="reaction ID" value="UER00270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004053">
        <property type="term" value="F:arginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006525">
        <property type="term" value="P:arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09989">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000012">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014033">
        <property type="entry name" value="Arginase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01229">
        <property type="entry name" value="rocF_arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782:SF3">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0056">Arginine metabolism</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="483"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="514"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="580"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS19447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="609" mass="66432" checksum="410D00B2935A377A" modified="2011-10-19" version="1">MSPSVLDDRAPAGAAPATTKTANGNGTSAPAPATYTVDSNTPLNTSMTPSKFLSHPHDLGIVAVGFAGGQGKAGVDAAPSALIEAGLLASLHDDLGYNLHGHDAVHNYSDLIPASPELDPPYRGMKNPRAVSAVTRRIAEQVYSHAREGRMVLTLGGDHSIAIGTIAGSAQAVKERLGKEIAVIWVDAHADINTPESSPSGNIHGMPLAFLTGLAKEDKEEFFGWIKEEQRLNIKKLVYIGLRDVDPVEKRILRENGVKAFSMFDVDRYGIGRVMEMALAHIGADTPIHLSFDVDALDPMWAPSTGTPVRGGLTLREGDYICESVHLTGQLVAVDLVEVNPKLAPETDLGAHETIRTGCSLLPPAVPPDGDPKHNVNVQDSKQAWEQSHDCGRTFSNEHHDPLTDPAVADAAVPAGIMASTVTSGSSSLVYERRVVERVHRYHWPAIQLNFWMLIMLAASCLIIGVFATFVETLHVLEQPIPWYYPYYITVACLTIAFIFLLLWLIFQRRLLPSIVMVGAFIIFVMWLVGLVVISIQLWGPRNSISSRCNIYVFGRDPKPKGESDVTRSWLQQKSVCQSWQAVFAFGLIGQIFLFWIMVMAYSVFVDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBJ6</accession>
    <name>G0SBJ6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Condensin complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0053810</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="15 16 17" key="2">
        <citation type="journal article" date="2019" name="Mol. Cell" volume="74" first="1175" last="1188.e9">
            <title>Structural Basis of an Asymmetric Condensin ATPase Cycle.</title>
            <authorList>
                <person name="Hassler M."/>
                <person name="Shaltiel I.A."/>
                <person name="Kschonsak M."/>
                <person name="Simon B."/>
                <person name="Merkel F."/>
                <person name="Tharichen L."/>
                <person name="Bailey H.J."/>
                <person name="Macosek J."/>
                <person name="Bravo S."/>
                <person name="Metz J."/>
                <person name="Hennig J."/>
                <person name="Haering C.H."/>
            </authorList>
            <dbReference type="PubMed" id="31226277"/>
            <dbReference type="DOI" id="10.1016/j.molcel.2019.03.037"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) OF 765-898</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the CND2 (condensin subunit 2) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695717.1">
        <property type="nucleotide sequence ID" value="XM_006695654.1"/>
    </dbReference>
    <dbReference type="PDB" id="6Q6E">
        <property type="method" value="NMR"/>
        <property type="chains" value="A=112-209"/>
    </dbReference>
    <dbReference type="PDB" id="6QJ2">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="B=765-898"/>
    </dbReference>
    <dbReference type="PDB" id="6QJ3">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.30 A"/>
        <property type="chains" value="B=225-418"/>
    </dbReference>
    <dbReference type="PDB" id="6QJ4">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="5.80 A"/>
        <property type="chains" value="B=225-418, E=764-898"/>
    </dbReference>
    <dbReference type="PDBsum" id="6Q6E"/>
    <dbReference type="PDBsum" id="6QJ2"/>
    <dbReference type="PDBsum" id="6QJ3"/>
    <dbReference type="PDBsum" id="6QJ4"/>
    <dbReference type="AlphaFoldDB" id="G0SBJ6"/>
    <dbReference type="SASBDB" id="G0SBJ6"/>
    <dbReference type="SMR" id="G0SBJ6"/>
    <dbReference type="STRING" id="759272.G0SBJ6"/>
    <dbReference type="GeneID" id="18259419"/>
    <dbReference type="KEGG" id="cthr:CTHT_0053810"/>
    <dbReference type="eggNOG" id="KOG2328">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010510_0_1_1"/>
    <dbReference type="OMA" id="FRKTCAD"/>
    <dbReference type="OrthoDB" id="362021at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022816">
        <property type="entry name" value="Condensin_barren_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108:SF9">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05786">
        <property type="entry name" value="Cnd2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017126">
        <property type="entry name" value="Condensin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="15 16 17" id="KW-0002">3D-structure</keyword>
    <keyword evidence="10 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="8 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="199"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="300"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="411"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="662"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="700"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="794"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="211"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="319"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="710"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="796"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="813"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR017126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS18772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="6Q6E"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="6QJ2"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PDB" id="6QJ3"/>
        </source>
    </evidence>
    <sequence length="898" mass="98883" checksum="E038A3095FF73C9B" modified="2011-10-19" version="1">MPRVAPHRRSGSRVGSGSFLESPFKSPAKLPLADDAIEKAERAQGRKAAHEAQINQIRSAATSTPRKSSGAFNPDLDHGASPNSTPRTPHRRRSAVRETILLDDEEVVVGGRAVTPMKRVPILANFEEWMKMATDNKINAANSWNFALIDYFHDMSLLKEGDSVNFQKASCTLDGCVKIYTSRVDSVATETGKLLSGLADSRDSKKKDREDGGEDDDEEEEEVDEDGTVRKKPKKKTQRSSEATLAPSFASLQLKKLELEFAVDPFFKKASADFDEGGAKGLLLNHLMIDSQGRIVFDSSDDAEDVAEASAKPSREADDERPDSEDADADGDISMTDRDASAPGQVETQPEEEDEDVEIDVAALGAKYFPDLSILDSLDVCPSLKTFDLGDPSGSLYIPFLKVPDDWRHDQEKEKTPGLGSLGNKSAMFIDDENPDGFDDDDGLGTFDMGADVGFGEGGEAWAKEAALEPHAMRVYDAGLGDGTEGDGEGDGADLMDAGTGEYVVAMSQPRSAEKIHEDILSYFDQALQKNWTSAEHWRIRKIKDVNKPNEPTRQRKEKQPFEIDFVSPLDKALAEIIYTKASSNATISMPKKDWKSKTKNLLPDDKHFSSKQLLSLFLKPKARMGRRRVLKTSRIGNIDSERHDDLPEGEVDEAFWATQKAPLANGNDRPGRHPDDDDEPLPQGDYDANFFADDGLPFAGGMDDDDDMDRFSDAREHFSPEPGAGGPGMNSTAGLQDLATGIMGQNPGDGAFGTNLVTQGRRVRPEYVQYARVAKKVDVRRLKEEIWKGMGFDELTSSNSNDTSQLQTPARQAEEQRSPESADGPNGKDKDPTLRFTDVMNSLQRVYPKQVMDDISTSYCFICLLHLANEKGLVIEKTDTLDELYIRKDWSAVVGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCD8</accession>
    <name>G0SCD8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0056860</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Ubiquitin thioesterase component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Deubiquitinates the creA catabolic repressor and the quinate permease qutD. Also plays a role in response to carbon starvation and the control of extracellular proteases activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with creA, creC and qutD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696009.1">
        <property type="nucleotide sequence ID" value="XM_006695946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCD8"/>
    <dbReference type="STRING" id="759272.G0SCD8"/>
    <dbReference type="GeneID" id="18259724"/>
    <dbReference type="KEGG" id="cthr:CTHT_0056860"/>
    <dbReference type="eggNOG" id="KOG1864">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008279_0_2_1"/>
    <dbReference type="OMA" id="PIDQANI"/>
    <dbReference type="OrthoDB" id="27652at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02663">
        <property type="entry name" value="Peptidase_C19G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000075">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase creB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF733">
        <property type="entry name" value="RE52890P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="10">
        <location>
            <begin position="57"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="91"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="523"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="748"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="840"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="555"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="590"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="763"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="868"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="879"/>
            <end position="906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS19064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="926" mass="102804" checksum="2E7D9ACA67581AD6" modified="2011-10-19" version="1">MAGFFQKLKAAGTGISRSDSNASKNTKKEDPTKDLSPVEKLLYNAGPIRPDGSDKFFGLENFGNTCYCNSIVQALYHSEHFRENVMNYPPPAPWDNPDEPKSKLSVTVRPPPQPNGTVTGPSKPGQTGRTSLSGGQLAPSMGPLRPEDRPDSPEYKKKQAMLKGPVLDLTQECSDPYGMKECTFTGLKDIFTALIESQSRTGVLSPQRFLDIFKRDNEMFRNSMHQDAHEFYGIVLNDVIANVEENAKRMQEIAESKGIKLNPEGESGSRAPGTGWVHDIFEGVLTSETRCLTCETASQRDETFLDLSIDLEEHSSVTSCLQKFSAEEMLCERNKFFCDHCGGLQEAEKRMKVKKLPKILALHLKRFKYTEDYSRLQKLFHRVVYPYHLRLFNTTDDAQDPDRLYELYAVVVHIGGNAYHGHYVVVIKTKDRGWLLFDDEMVEPVDKHFVRNFFGDKPGMACAYVLFYQETTFEKVREELDAEGLDVDQIKPAAKVPNLAATAEVNGEPESNEVPLTRIKTQPLPPLAEDELSPLPNGKAIKGGGGDSPVDSIPHSLSRSRSQPVLVSWSGSSDVPHEPDKSEPVIASYKSEKERKKELKAQEKAQKAQEKAQKAAEKEQARLAAKERQGNLRKAQEAAKECEDLQKAIEESKRMAAEEEKRHKREGSEIASSDGGDSHQHHHHHQQQQQQQQQQRRHHSQSFLSRASRTGKAMTRKSIATFINKAFLPEYPDMAHTDHHNHKVVVPERPSDVASSSKASDRTVAATDVTGAGTATPAESEISHPTTITSMTTASTMPLHHQNGTAAAAAATTILANGDVTKPGTAAGCNLEALSSYPSRTDTAVSSGAGAPPPSSHHSHHSASDHHNYHHYHRFFHRHDKDKDKDHKDKEKDKEKEKTPLKERFHFGLGKKKSGVLGAGSNTSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCG2</accession>
    <name>G0SCG2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ubiquinone biosynthesis monooxygenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0057100</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UbiH/COQ6 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696033.1">
        <property type="nucleotide sequence ID" value="XM_006695970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCG2"/>
    <dbReference type="STRING" id="759272.G0SCG2"/>
    <dbReference type="GeneID" id="18259748"/>
    <dbReference type="KEGG" id="cthr:CTHT_0057100"/>
    <dbReference type="eggNOG" id="KOG3855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_8_0_1"/>
    <dbReference type="OMA" id="VKQMQVW"/>
    <dbReference type="OrthoDB" id="683240at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000245">
        <property type="entry name" value="Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018168">
        <property type="entry name" value="Ubi_Hdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010971">
        <property type="entry name" value="UbiH/COQ6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051205">
        <property type="entry name" value="UbiH/COQ6_monooxygenase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01988">
        <property type="entry name" value="Ubi-OHases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01304">
        <property type="entry name" value="UBIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="40"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="341"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS19088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="432" mass="47130" checksum="8BE9428083BF1BAC" modified="2011-10-19" version="1">MDKLLRRRGTYVCRSCIQSFQRQPRRGYATAAPSQPDIFDVVCVGGGPAGLSANPVTAHLRMALVEAQDLSKLRAWKLPPDRYSNRCSSLTPASASFLDRIGAWKHIDRDRVQPYHEMQVWDGVSGARIEFDSPPTNGGTIAYMIENLNLISGLLKRLDELGGVAMYDSSRVEHITYGEETEEVDLRQWPVVHLSSGAQLAARLLVGADGANSPVRTFAGIQARGWDYDRHGVVATLQLSESTPNTFKTAYQRFLPTGPVALLPLPGPYASLVWSTTPQNAAHLKSLSSEDFVAMVNAAFRLSPVDLAYLHTIPSNHVDELTWRSQHTPFPSPPTIPYPVTAVQPQTVASFPLRLRHADSYTAHRIALLGDAAHTVHPLAGQGLNQGQGDVQALAGTVAEAVQHGMDLGVIGALQDYNGKRFMGRDGGLWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCT7</accession>
    <name>G0SCT7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0058380</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2017" name="Nat. Struct. Mol. Biol." volume="24" first="954" last="964">
            <title>3.2-A-resolution structure of the 90S preribosome before A1 pre-rRNA cleavage.</title>
            <authorList>
                <person name="Cheng J."/>
                <person name="Kellner N."/>
                <person name="Berninghausen O."/>
                <person name="Hurt E."/>
                <person name="Beckmann R."/>
            </authorList>
            <dbReference type="PubMed" id="28967883"/>
            <dbReference type="DOI" id="10.1038/nsmb.3476"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.20 ANGSTROMS)</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2017" name="PLoS ONE" volume="12" first="e0178752" last="e0178752">
            <title>Structural basis for 5'-ETS recognition by Utp4 at the early stages of ribosome biogenesis.</title>
            <authorList>
                <person name="Calvino F.R."/>
                <person name="Kornprobst M."/>
                <person name="Schermann G."/>
                <person name="Birkle F."/>
                <person name="Wild K."/>
                <person name="Fischer T."/>
                <person name="Hurt E."/>
                <person name="Ahmed Y.L."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="28575120"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0178752"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) OF 2-884</scope>
    </reference>
    <reference evidence="7 8 9" key="4">
        <citation type="journal article" date="2019" name="Mol. Cell" volume="75" first="1256" last="1269.e7">
            <title>Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration.</title>
            <authorList>
                <person name="Cheng J."/>
                <person name="Bassler J."/>
                <person name="Fischer P."/>
                <person name="Lau B."/>
                <person name="Kellner N."/>
                <person name="Kunze R."/>
                <person name="Griesel S."/>
                <person name="Kallas M."/>
                <person name="Berninghausen O."/>
                <person name="Strauss D."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="31378463"/>
            <dbReference type="DOI" id="10.1016/j.molcel.2019.06.032"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.50 ANGSTROMS)</scope>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696158.1">
        <property type="nucleotide sequence ID" value="XM_006696095.1"/>
    </dbReference>
    <dbReference type="PDB" id="5N1A">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.15 A"/>
        <property type="chains" value="A/B=2-884"/>
    </dbReference>
    <dbReference type="PDB" id="5OQL">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="D=1-884"/>
    </dbReference>
    <dbReference type="PDB" id="6RXT">
        <property type="method" value="EM"/>
        <property type="resolution" value="7.00 A"/>
        <property type="chains" value="UD=1-884"/>
    </dbReference>
    <dbReference type="PDB" id="6RXU">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.50 A"/>
        <property type="chains" value="UD=1-884"/>
    </dbReference>
    <dbReference type="PDB" id="6RXV">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.00 A"/>
        <property type="chains" value="UD=1-884"/>
    </dbReference>
    <dbReference type="PDB" id="6RXX">
        <property type="method" value="EM"/>
        <property type="resolution" value="7.10 A"/>
        <property type="chains" value="UD=1-884"/>
    </dbReference>
    <dbReference type="PDB" id="6RXY">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.70 A"/>
        <property type="chains" value="UD=1-884"/>
    </dbReference>
    <dbReference type="PDB" id="6RXZ">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.40 A"/>
        <property type="chains" value="UD=1-884"/>
    </dbReference>
    <dbReference type="PDBsum" id="5N1A"/>
    <dbReference type="PDBsum" id="5OQL"/>
    <dbReference type="PDBsum" id="6RXT"/>
    <dbReference type="PDBsum" id="6RXU"/>
    <dbReference type="PDBsum" id="6RXV"/>
    <dbReference type="PDBsum" id="6RXX"/>
    <dbReference type="PDBsum" id="6RXY"/>
    <dbReference type="PDBsum" id="6RXZ"/>
    <dbReference type="AlphaFoldDB" id="G0SCT7"/>
    <dbReference type="EMDB" id="EMD-10051"/>
    <dbReference type="EMDB" id="EMD-10052"/>
    <dbReference type="EMDB" id="EMD-10053"/>
    <dbReference type="EMDB" id="EMD-10054"/>
    <dbReference type="EMDB" id="EMD-10055"/>
    <dbReference type="EMDB" id="EMD-10056"/>
    <dbReference type="EMDB" id="EMD-3847"/>
    <dbReference type="SMR" id="G0SCT7"/>
    <dbReference type="IntAct" id="G0SCT7">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0SCT7"/>
    <dbReference type="GeneID" id="18259876"/>
    <dbReference type="KEGG" id="cthr:CTHT_0058380"/>
    <dbReference type="eggNOG" id="KOG2048">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002392_2_1_1"/>
    <dbReference type="OMA" id="MWDVELP"/>
    <dbReference type="OrthoDB" id="8883818at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_b-propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046351">
        <property type="entry name" value="UTP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5 6 7" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="272"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="580"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="722"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="602"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="788"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="799"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS19213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="5N1A"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="5OQL"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="6RXT"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="6RXU"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="6RXV"/>
        </source>
    </evidence>
    <sequence length="884" mass="97563" checksum="BDE5AFD08D56F166" modified="2011-10-19" version="1">MDIHRCRFVRYPASAINAVAFTHSALPVVSSSKKYLQKNIQVRLAIGRANGDIEIWNPLNGGWYQEVIIPGGKDRSVDGLVWVTDPDEEMADGKIIHGKSRLFSIGYTTTITEWDLEKARAKKHASGQHGEIWCFGVQPLPHKANAAAAQNRKLVAGTVDGNLVLYSIEDGDLKFQKTLTRTPSKKTKFVSIAFQSHNIVIVGCSNSTICAYDVRTGTMLRQMTLGTDLTGGSKNIIVWAVKCLPNGDIVSGDSTGQVCIWDGKTYTQAQRIQSHTQDVLCLSVSADGSKIISGGMDRRTAVYEPMAGQSGRWSKVFHRRYHQHDVKAMASFEGKGMSVVVSGGSDASPIVLPLRALGKEFHRTLPHLPQHPTVLSAPKARYILSWWENEIRIWHLLNSAQQFLDDPQAPLNLRKNRKFLAQVLIKGASHITSASISEDGTLLAASTPTDVKVFHLDPAAAQRNGQLYIKKVNMTGTGLGATRVQISPDKRWICWAEEGSKVMISRVHATESADGISYTVSVPHKLHRLRRQIPKHILLGGLGSYDRNVSQIAFSADSRMLSVADLAGYIDTWVLRGPGEGVNGTGGEDSDGESAASSSDSSDEKSEDIAGERWARNPKAAMIPKLSAAPVVLSFSPTPRDDGDYDLLVVTTLKQLLIFNPLRGMLSEWSRRNTYPKLPEPFRDTRDQVKGIVWQGQRAWFYGVASLFMFDLSQDFSPEKDLVETNGHKQGTKRKRGAHESGAGSKIEKHSLVPQRIRAASAPDGTKWEDIEMVDADDQKSVGVSSGVDDDDDETDGSELQRLREENREANSSANAEKEGPSRAKWWHTYQFRPIMGIVPIEGMMEKKLGAVEGIPPLEVALIERPLSEDDLPERYFAEGEWER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0SD66</accession>
    <name>G0SD66_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative COP9 signalosome protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0059120</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696231.1">
        <property type="nucleotide sequence ID" value="XM_006696168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SD66"/>
    <dbReference type="STRING" id="759272.G0SD66"/>
    <dbReference type="GeneID" id="18259950"/>
    <dbReference type="KEGG" id="cthr:CTHT_0059120"/>
    <dbReference type="eggNOG" id="KOG3250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_754399_0_0_1"/>
    <dbReference type="OrthoDB" id="10265275at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF5">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22061">
        <property type="entry name" value="CSN7_HB_subdom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="5">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="264"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="328"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="183"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="264"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS19286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="367" mass="39160" checksum="054575F98AB3D881" modified="2011-10-19" version="1">MEQVKALNALEPFVALSKSAASPRVAADLVMQATSAPNTFIFTELLETPQIQALSKSEEFASYLNLLQIFSYGTYADYKSSPGLPELNEAQRLKLRQLSLLTLARKDAGAGSPALTYAALQEALDLPTRQALEELVISAVYAGLIKAQLNPKESVVQINSVAPLRDVAPTAVDSLLASLQAWSDRCDDTLAKLEREMQRVRDNANKRAAREAARAEETKKLIEAEQNGEDAPRLPPLFFEKKYTKAITVPGPATAAIASAASSAAGPSSTPAVASPSTMFPGPNPMELPIRTKPGTAPADGDEASALSDKGPSSKWTKVLAIFKLKGKVKAKDGSPLPEDDDDANTDNKVNSTHPSRRPAHTTVSIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0SD92</accession>
    <name>G0SD92_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein-lysine N-methyltransferase EFM6</fullName>
            <ecNumber evidence="1">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Elongation factor methyltransferase 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">EFM6</name>
        <name evidence="2" type="ORF">CTHT_0050950</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. METTL21 family. EFM6 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695438.1">
        <property type="nucleotide sequence ID" value="XM_006695375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SD92"/>
    <dbReference type="STRING" id="759272.G0SD92"/>
    <dbReference type="GeneID" id="18259133"/>
    <dbReference type="KEGG" id="cthr:CTHT_0050950"/>
    <dbReference type="eggNOG" id="KOG2793">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055721_2_1_1"/>
    <dbReference type="OMA" id="RRADMRF"/>
    <dbReference type="OrthoDB" id="407325at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03198">
        <property type="entry name" value="Methyltr_EFM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033684">
        <property type="entry name" value="EFM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF152">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EFM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="87"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="245" mass="27479" checksum="5C37493DD0259C06" modified="2011-10-19" version="1">MTEKKQTPSPEFSPLGFDEDIAPLPEYKAAGTTEVDFSGLLGEPLKLHEDLRSGCGGQLWPAGMVLAKHMLRYHREKLQSARILELGAGGGVVGLTVAKGCKNLKHPLYITDMVEMEPLMKYNISLNGLADRVRARILNWGEPLSQEVVDFKPDVILAADCVYLEAAFPLLMQTLKDLLELEPKATVYFCFKKRRRADMQFLKNARKAFTVTEIEDEDRPVFSRDNLFLYTFTRKDSGSSSSLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDE5</accession>
    <name>G0SDE5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamate-5-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="2">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0051500</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-glutamate 5-semialdehyde + phosphate + NADP(+) = L-glutamyl 5-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="2"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695491.1">
        <property type="nucleotide sequence ID" value="XM_006695428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDE5"/>
    <dbReference type="STRING" id="759272.G0SDE5"/>
    <dbReference type="GeneID" id="18259188"/>
    <dbReference type="KEGG" id="cthr:CTHT_0051500"/>
    <dbReference type="eggNOG" id="KOG4165">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030231_0_1_1"/>
    <dbReference type="OMA" id="KTQRYGT"/>
    <dbReference type="OrthoDB" id="1934954at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000006">
        <property type="entry name" value="Gamma-glutamyl phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020593">
        <property type="entry name" value="G-glutamylP_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001221">
        <property type="entry name" value="PRK00197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063:SF8">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063">
        <property type="entry name" value="GLUTAMATE SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01223">
        <property type="entry name" value="PROA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="12">
        <location>
            <begin position="10"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS18546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="447" mass="47527" checksum="4F3525D3ABD0CA63" modified="2011-10-19" version="1">MSLTNASPLDAAKAAKSASHVLATLSTSARNDALTAIHAALTASRDEILAANARDLELARQAAADGKLSSSLVARLDLGKKGKYDDMLKGILDVRDLPDPVGKVTLRTKLDEGLELERVTCPIGVLLIIFEARPEVIANIAALAIKSGNAAILKGGKESTESFIAISRAISSALEKTSVPNDAIQLVTTRDVIPELLALDRHIDLVIPRGSSDLVRYIKTTTRIPVLGHADGLCAIYLEQSADPATAPDIIVDAKTSYPAACNALETLLVQDTALTTLLPPVASALAAKGVELRCDEKSKAALASALPDLKIVDATEEDYYTEFLSLTLAIKTVSSLDEAITHINTHGSHHTDAILTSDKAQAEQFMSAVDSSGVYWNASTRFADGTRYGFGTEVGISTNKIHSRGPVGLEGLMIYKYKLRGQGHVSAVYGEGEGKKRYLHQPLPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDU9</accession>
    <name>G0SDU9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0053070</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695645.1">
        <property type="nucleotide sequence ID" value="XM_006695582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDU9"/>
    <dbReference type="STRING" id="759272.G0SDU9"/>
    <dbReference type="GeneID" id="18259345"/>
    <dbReference type="KEGG" id="cthr:CTHT_0053070"/>
    <dbReference type="eggNOG" id="KOG0752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_10_3_1"/>
    <dbReference type="OMA" id="MYVCYGA"/>
    <dbReference type="OrthoDB" id="18574at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090422">
        <property type="term" value="F:thiamine pyrophosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000011">
        <property type="entry name" value="Mitochondrial thiamine pyrophosphate carrier 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF10">
        <property type="entry name" value="SLC (SOLUTE CARRIER) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 13" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="14"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="127"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="221"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS18700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="329" mass="36394" checksum="E621E826E6B3EDC6" modified="2011-10-19" version="1">MSPKDSGDSLKDEGSRLQVTLAGATAGLISRFVIAPLDVVKIRLQLQPHSLSDPLLSSRLDQLRGGPIYKGTLRTMQHIVRHEGLPGLWKGNVPAELLYVCYSAVQFTTYRTTTQLLRAVFEQDSLPQAAESFVCGATGGAAATAVTYPLDLLRTRFAAQGNDDRVYPNLRRAIRQIYRDEGLRGFFRGLGPGVAQIVPYMGCFFAFYETLRPVLGPLDLPFSSGTAVAGTIASVAAKTVTFPLDLVRKRIQVQGPTRGRYVHKNIPEYKGGAVGTFRTILRMEGMRGLYRGLTVSLVKAAPASAVTMWTYERALRFYEGVWERFELRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G0SE03</accession>
    <name>G0SE03_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0061950</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0220 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696511.1">
        <property type="nucleotide sequence ID" value="XM_006696448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SE03"/>
    <dbReference type="STRING" id="759272.G0SE03"/>
    <dbReference type="GeneID" id="18260233"/>
    <dbReference type="KEGG" id="cthr:CTHT_0061950"/>
    <dbReference type="eggNOG" id="KOG3393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096876_0_0_1"/>
    <dbReference type="OMA" id="VHITFVD"/>
    <dbReference type="OrthoDB" id="268928at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007919">
        <property type="entry name" value="UPF0220"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13180">
        <property type="entry name" value="SMALL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05255">
        <property type="entry name" value="UPF0220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS18180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="191" mass="20977" checksum="E458904A187BCCFB" modified="2011-10-19" version="1">MSLPEERLWRFRKPEWLNSIWVRNAGVYTAGGLFSLAFYTLLDSAVWSKSSRNGSTIHVGFVDWLPFIFSALGMLVISNIEKSRLSSESFSYTGYSSSVAWKARVILFLGFASLAGGMAGGVTVFVLKYVVPGVQWPALGMGVENLVSNFLVGLSTVVLWAAVRILSGGITPFDLGAYYFKTPTGKLYTFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0SE52</accession>
    <name>G0SE52_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flavoprotein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0062460</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696560.1">
        <property type="nucleotide sequence ID" value="XM_006696497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SE52"/>
    <dbReference type="STRING" id="759272.G0SE52"/>
    <dbReference type="GeneID" id="18260284"/>
    <dbReference type="KEGG" id="cthr:CTHT_0062460"/>
    <dbReference type="eggNOG" id="KOG0672">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033319_3_2_1"/>
    <dbReference type="OMA" id="SEHDSHY"/>
    <dbReference type="OrthoDB" id="1532798at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071513">
        <property type="term" value="C:phosphopantothenoylcysteine decarboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF6">
        <property type="entry name" value="PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS18229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="207" mass="23343" checksum="4350A92C6C53B38B" modified="2011-10-19" version="1">MVLLQCIRFRVLTYHCLPVPVIVQALAKYKGVLSIRIVLTESATHFLAGQSPEQPTVLSLLHLPNVDAVYRDQDEWGPQPWKRGANILHIELRRWADLMVVAPLSANTLAKAMWRHPITEKQMRVLEQDWGVKEDVHIAGRTRAIMGWFEVLKPISKTLACGDTGGAMASVDTICEAIEQRLELNDALEAKTMEDEEQRRAQALANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>G0SER3</accession>
    <name>G0SER3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0059420</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS17929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696260.1">
        <property type="nucleotide sequence ID" value="XM_006696197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SER3"/>
    <dbReference type="GeneID" id="18259980"/>
    <dbReference type="KEGG" id="cthr:CTHT_0059420"/>
    <dbReference type="eggNOG" id="ENOG502SPR5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071125_1_0_1"/>
    <dbReference type="OMA" id="GSGPWFY"/>
    <dbReference type="OrthoDB" id="2349272at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS17929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="164" mass="17993" checksum="0E3132444EA5E5EE" modified="2011-10-19" version="1">MPKSTSCEGAEFPNECRTAEQAAPFVAKALIPFSNEEKAALLALMGFESVDFRYKHNVFPGVEGQGTANMMMPKFVTEYASDLFGDDEISGKSLSQILAMVTLDDYNFGSAGWFLVKHCDHSVRDVLKTGTDAGWNAYMSCVGVNGSDQGRMAYWIRAKQAFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEU2</accession>
    <name>G0SEU2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0059710</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:16638"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the chitin synthase family. Class IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS17958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696289.1">
        <property type="nucleotide sequence ID" value="XM_006696226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEU2"/>
    <dbReference type="STRING" id="759272.G0SEU2"/>
    <dbReference type="GeneID" id="18260009"/>
    <dbReference type="KEGG" id="cthr:CTHT_0059710"/>
    <dbReference type="eggNOG" id="KOG2571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002572_1_0_1"/>
    <dbReference type="OMA" id="DIMGLCG"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054295">
        <property type="entry name" value="CHS4-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF16">
        <property type="entry name" value="CHITIN SYNTHASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22997">
        <property type="entry name" value="CHS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1039"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1066"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1092"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1118"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="14">
        <location>
            <begin position="396"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="553"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS17958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1245" mass="139045" checksum="BE75912FA527BDED" modified="2011-10-19" version="1">MSLPERPGATPTYEERHSYRTQSRRSRPADVEAGGYAPLDGQSHHQRGPSASSFADTIPSPNSEIEQTPLSPTSPQTPRGPSSPSFQRKRSLIRPERNRITKDHPNYHYRKHAQNMATMPSTTGNDPIIEDIEGTTDLSGAGSRNDDALSDQSPPRRHRSDDVEKGRTRRRTNSGKITKEKRKQQEQLRPPSLWNIYCAIVTFWCPGFVLKCFGMPTKAQQRAWREKMGLISLILMIMAFVGFLTFGFTQVVCGRPPLRLRVNEVTAGYMIFHGSAYNLAGSGHPPAMGIPRRLDGSAANVLYDLPEKHGGKDGSFLFQNVNGKCKGLIKAAPGSDVPTDRDGNLAWYFPCTTFNQDGSSKPNKTIPYYLGYACHTTAKARDAFYLNLTNAADVYFTWDDVKNSSRNLIVYSGNVLDLDLLYWFNDTQVTYPDRFKELRNRNSSLNKAVRGRDVTRAFQSPGDKQMAQCFEEIIKVGYVDTDTVGCIASKVVLYISLVLILSVVLSRFVLALIFQWFIAPTYAAAKTSQSSDPRKRARQIEDWSEDIYRAPPRMPGDIGSSVNGSDRHSKRSSFLPTTSRFSAVYGNDRASRKSGVPTTMTTQNAASQYLSPGPYRHGNDSRTSFLRSDPYASTVSASDGPGPAGFIHEAVVPQPPADYMPFGFPLAHAICLVTAYSEGELGLRTTLDSIAMTDYPNSHKVILVICDGIIKGKGESMSTPDIVLGMLKDQLLPPEEVQAYSYVAVASGAKRHNMAKVYAGFYDYGPNSPIPVEKQQRVPMMVVVKCGTPEEEHAAKPGNRGKRDSQIILMSFLQKVMFDERMTELEYEMFNGLWRITGISPDFYEMVLMVDADTKVFPDSLTHMISAMVKDPEIMGLCGETKIANKRASWVSAIQVFEYFISHHLAKSFESVFGGVTCLPGCFCMYRIKAPKGAQNYWVPILANPDVVEHYSENVVDTLHKKNLLLLGEDRYLSTLMLRTFPKRKQIFVPQAVCKTTVPDEFRVLLSQRRRWINSTIHNLMELILVKDLCGTFCFSMQFIVFVELIGTLVLPAAIAFTFYVGKYMLFVRSLILPRLLITEVIISIVNSPPQIIPLILLALILGLPAVLIVVTAHSWSYVVWMLIYLLSLPIWNFVLPTYAFWKFDDFSWGETRKTAGDTKGGGHGDAEGEFDSSKITMKRWAEFERDRRLLAQQQQQAAQMRHNSYSHASHWGSMENVIGGPGGGSQAHLMGGHGPYDGGYYSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEZ4</accession>
    <name>G0SEZ4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bromodomain associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0060230</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696341.1">
        <property type="nucleotide sequence ID" value="XM_006696278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEZ4"/>
    <dbReference type="STRING" id="759272.G0SEZ4"/>
    <dbReference type="GeneID" id="18260061"/>
    <dbReference type="KEGG" id="cthr:CTHT_0060230"/>
    <dbReference type="eggNOG" id="ENOG502S96D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064111_0_0_1"/>
    <dbReference type="OMA" id="EWEEDWQ"/>
    <dbReference type="OrthoDB" id="5402929at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00076">
        <property type="entry name" value="HFD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromodomain associated" evidence="6">
        <location>
            <begin position="6"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="261"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS18010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="307" mass="32792" checksum="727AB7524FF21B24" modified="2011-10-19" version="1">MTPPPPLYHALLRPAILQILRAAGYHAAKTNVLDTVTDLAARYLSHLCQLTALYASHNNEGEVSMFDMELLDEWERARSEIMAGANGAGGGQVDGGGDGNAGEVNGSGTGYGNQNANGVGNVNGASVTSSAPTKRPIPSVPVPVPTIVDVRMALQRAGAFMPERIIEEQEYLGVEDLRGVESFIAWATGPVNREIKRIALDGNDEASDYLDALKKKHSKNDDDSKYLGTLLGRSIDFGEEIVIEGWDCPSIEAWEERMRRAAVRPRDANADGQAEGVNGNGEKDSRPGSSGLSSLGDRSIAEDMDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0SF03</accession>
    <name>G0SF03_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0060330</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696350.1">
        <property type="nucleotide sequence ID" value="XM_006696287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SF03"/>
    <dbReference type="STRING" id="759272.G0SF03"/>
    <dbReference type="GeneID" id="18260071"/>
    <dbReference type="KEGG" id="cthr:CTHT_0060330"/>
    <dbReference type="eggNOG" id="ENOG502SCKF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097655_0_0_1"/>
    <dbReference type="OMA" id="HEIHIQF"/>
    <dbReference type="OrthoDB" id="5335351at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="152" mass="17380" checksum="F5D832418A330D32" modified="2011-10-19" version="1">MTDSSQSTESKPQQHQMGNDRLQVTTPEPHSNNNNNNNNGSKRTNSQTEKSPSTPGHLAPFDWDEFEARYEEALAAADRDEQELLREFDDLVKFFNVWASAASVHDTERGVKRLQTRERYVQIAEQSLLQKKKHLQEVVRAFQSALALLTQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G0SF12</accession>
    <name>G0SF12_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ras GTPase activator-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0060420</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696359.1">
        <property type="nucleotide sequence ID" value="XM_006696296.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0SF12"/>
    <dbReference type="GeneID" id="18260080"/>
    <dbReference type="KEGG" id="cthr:CTHT_0060420"/>
    <dbReference type="eggNOG" id="KOG2128">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000972_1_1_1"/>
    <dbReference type="OMA" id="KGVLVHW"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903479">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21206">
        <property type="entry name" value="CH_IQGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05127">
        <property type="entry name" value="RasGAP_IQGAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF14">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="4">
        <location>
            <begin position="295"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="3">
        <location>
            <begin position="1067"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="196"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="811"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="28"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS18028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1701" mass="194713" checksum="99BE5446647505F9" modified="2011-10-19" version="1">MASSYRPHPLRQSQTAEYPVHRQASTVSTASSSSSAYSSHSHSSSSTSYELGRSSMTSSPSSIYSSSGYGAYPGHKRGRSEVTSSSLRHPTSTLTSSQTYSSISQTSTRPAENIYQTARQSLRPLPQTPRPTTPPRAPIRHDRGHSVDIGKLSLTDYGRNTSPAPDTPPTPPHHHSPSPHLRPKSMLLTRADSVVRRASDAGSPPPLTHTHTTSLTTPELEKLSKSSTNQLRTLSKLAQDGADEFAIIPAAEVTGLRGRRRLQRTNRANNRRAYGWEGRNWMDKQRQFLQAYEYLCHIGEAKEWIEDVIQKAIPPIIELEEALRDGVTLAEVVEALNPHRRYKIFRHPKLQYRHSDNIAIFFNYLDEVQLPELFRFELIDLYEKKNIPKVIYCIHALSWLLYRKGIVTFRIGNLVGQLEFEHHELEATQKGLDKLGANVPSFGNMGADFGIEEPPEPEETEEERIERELAEQEAIITDFQAQIRGAMCRVKLGHMMQHLWDNEEWLIDLQSRIRGDFARQIYGYRLEMRRFATHLQAAARGFLVRRRLAIDAWATDLQSVARGFLVRRRQRRTKQIAKHVEKDILKLQSLLRATKVRSEVQEKRAQLEMAAGPIRHIQAKMRGFLVRQKMLAQEQEVQQTTAPAVASLQAAVRGFLQRKKLDAEKAELRLGTPAITELQAGIRAALLRKKIGEQQEELEDLTPVWTALQAAARGKLARGKVRGVQAELRQHVPDLGKLQAAIRAAAVRREISDKLDCLAECEEEIVALQANIRGMLERNRISNLLDALEAEEPAIVQLQAHIRGAMHRQKESAFLDELASHEEEIEQLQALARAVLTRVQVGRILDELDECEPIITELQAAAKGYIIRARFEDKRRHYLENMQKVVKIQSLVRAKLQGQAYKSLISGKNPPVNAVKNFVHLLNDSDFDFNEEVEFERLRKTVVQQVRQNEMLEQYIDQLDIKIALLVKNKITLDEVIKHQHTLGGHASSLLANTPIASTNQFDLKALNKGSRRKLELYQQLFFLLQTQPQYLARLFRRLREEGTPEKECKRIEHLMMGLFGYAQKRREEYYLLKLLGRSIREEVDACSTLHDYLRGSFFWMRLFNSYTRSPRDRKFLRDLMGPLIRDNIIDDPELDLESDPMQIYRSLINNEELRTGRPSRRPLDIPRELAIKDPETKAVFIDHLRDLREICDQFLILLEDLLPRMPYGLRFVCRQTFESLAQRFPREDHARLLQIVSNWLWRFYLQPALTAPENVGVIERQLSPLQKRNLGEVAKVLGQIASGRPFGGENIYLQPLNAFVAESVDRLTQLTEAIISVADAEATFDIDEFNDLYAKNKPTLYIKMSDIFAIHNLVASQLPVISPNRDDIIREIVHDLGSAKHNESEMTAAGSSDIQLFLTPKLQNLEDPDADVKALFMETKRCILYIIRVQTGANLMEILVKPITPEDENKWQAVLREDFANGSKGAYSDANMDISTMSYMELKRTALENVMRLEQMGRITRKNHYQDILNAIALDIRTKSRRRVQRQRELEGVRMTLSNLLEKAKYLEQQRKSYDDYIEQAMLTLQNKKGKKRFLLPFTKQYNHQRELERSGRVPKFGSYKYSARALSDKGVLVSWQGVPERDWGSINLTISCDEVGVFVLEGSKGHIQIPGASAVVSIEDLLQAQFETRQFMNLFEGGALKLNVNLLLHLVYKKFYRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0SF22</accession>
    <name>G0SF22_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Cellulase</fullName>
            <ecNumber evidence="3 9">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0060530</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 45 (cellulase K) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3 9"/>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696369.1">
        <property type="nucleotide sequence ID" value="XM_006696306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SF22"/>
    <dbReference type="SMR" id="G0SF22"/>
    <dbReference type="STRING" id="759272.G0SF22"/>
    <dbReference type="GeneID" id="18260091"/>
    <dbReference type="KEGG" id="cthr:CTHT_0060530"/>
    <dbReference type="eggNOG" id="ENOG502RXA6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045022_2_0_1"/>
    <dbReference type="OMA" id="ERDNECA"/>
    <dbReference type="OrthoDB" id="10035502at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052288">
        <property type="entry name" value="GH45_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000334">
        <property type="entry name" value="Glyco_hydro_45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39730">
        <property type="entry name" value="ENDOGLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39730:SF1">
        <property type="entry name" value="ENDOGLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02015">
        <property type="entry name" value="Glyco_hydro_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01140">
        <property type="entry name" value="GLYCOSYL_HYDROL_F45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409130" description="Cellulase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolases family 45 active site" evidence="11">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS01140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS18038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="247" mass="26326" checksum="E192EE28862FD681" modified="2011-10-19" version="1">MHLSQLALPLLLAAGAHAQGAQGTGRTTRYWDCCKPSCAWPGKSNALQPVQTCNAQDQPLNDGGNTRSGCDSGGSAFMCSNQSPWALNETLSYGWAAVRIAGQSEFNWCCACYELTFTSGPVAGKKMIVQATNTGGDLGSNHFDIAIPGGGVGIFNACTQQYGAPPNGWGERYGGIRSRSECDSFPEALKAGCYWRFDWFLGADNPDVSFKQVACPAAITAKSKCVRQRDVIDQTPTGPEIVPTWTP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2021-09-29" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0SF70</accession>
    <name>PCNA_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA sliding clamp PCNA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Proliferating cell nuclear antigen</fullName>
            <shortName>PCNA</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">CTHT_0061010</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2021-04" db="UniProtKB">
            <authorList>
                <person name="MacNeill S."/>
            </authorList>
        </citation>
        <scope>GENE MODEL REVISION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Confers DNA tethering and processivity to DNA polymerases and other proteins. Auxiliary protein of DNA polymerase delta and epsilon, is involved in the control of DNA replication by increasing the polymerases' processivity during elongation of the leading strand. Additionally, acts as a molecular switch to control the choice of two parallel branches of the DNA damage tolerance (DDT) pathway (also known as the post-replication repair (PRR) pathway) that bypasses replication-blocking lesions without removing them; the translesion DNA synthesis (TLS) branch, and the template-switching (TS) branch; monoubiquitinated PCNA promotes the TLS branch and polyubiquitinated PCNA promotes the TS branch.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Monoubiquitinated on Lys-164 upon DNA damage, and then polyubiquitinated through 'Lys-63'-linkage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PCNA family.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EGS18086" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18086.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696417.1">
        <property type="nucleotide sequence ID" value="XM_006696354.1"/>
    </dbReference>
    <dbReference type="PDB" id="7O1E">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.34 A"/>
        <property type="chains" value="A=2-259"/>
    </dbReference>
    <dbReference type="PDB" id="7O1F">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.45 A"/>
        <property type="chains" value="A/B/C/D/E/F=2-259"/>
    </dbReference>
    <dbReference type="PDB" id="8P9O">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.45 A"/>
        <property type="chains" value="A/B/C=2-259"/>
    </dbReference>
    <dbReference type="PDB" id="8Q7I">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.95 A"/>
        <property type="chains" value="A=2-259"/>
    </dbReference>
    <dbReference type="PDBsum" id="7O1E"/>
    <dbReference type="PDBsum" id="7O1F"/>
    <dbReference type="PDBsum" id="8P9O"/>
    <dbReference type="PDBsum" id="8Q7I"/>
    <dbReference type="AlphaFoldDB" id="G0SF70"/>
    <dbReference type="SMR" id="G0SF70"/>
    <dbReference type="STRING" id="759272.G0SF70"/>
    <dbReference type="GeneID" id="18260139"/>
    <dbReference type="KEGG" id="cthr:CTHT_0061010"/>
    <dbReference type="eggNOG" id="KOG1636">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043978_3_0_1"/>
    <dbReference type="OrthoDB" id="534348at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043626">
        <property type="term" value="C:PCNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00577">
        <property type="entry name" value="PCNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.150.10:FF:000006">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.150.10:FF:000008">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.70.10.10:FF:000001">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.150.10">
        <property type="entry name" value="DNA Polymerase III, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00317">
        <property type="entry name" value="DNApol_clamp_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022649">
        <property type="entry name" value="Pr_cel_nuc_antig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022659">
        <property type="entry name" value="Pr_cel_nuc_antig_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00590">
        <property type="entry name" value="pcna"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02747">
        <property type="entry name" value="PCNA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00339">
        <property type="entry name" value="PCNACYCLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01251">
        <property type="entry name" value="PCNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00293">
        <property type="entry name" value="PCNA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1017">Isopeptide bond</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0832">Ubl conjugation</keyword>
    <feature type="chain" id="PRO_0000453181" description="DNA sliding clamp PCNA">
        <location>
            <begin position="1"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="DNA-binding region" evidence="2">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate" evidence="1">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate" evidence="1">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="strand" evidence="6">
        <location>
            <begin position="2"/>
            <end position="7"/>
        </location>
    </feature>
    <feature type="helix" evidence="6">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="turn" evidence="6">
        <location>
            <begin position="20"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="strand" evidence="6">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="strand" evidence="6">
        <location>
            <begin position="34"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="strand" evidence="6">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="helix" evidence="6">
        <location>
            <begin position="54"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="strand" evidence="6">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="strand" evidence="6">
        <location>
            <begin position="66"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="helix" evidence="6">
        <location>
            <begin position="72"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="strand" evidence="6">
        <location>
            <begin position="86"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="strand" evidence="6">
        <location>
            <begin position="97"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="strand" evidence="6">
        <location>
            <begin position="106"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="strand" evidence="6">
        <location>
            <begin position="111"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="strand" evidence="6">
        <location>
            <begin position="134"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="helix" evidence="6">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="strand" evidence="6">
        <location>
            <begin position="156"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="strand" evidence="6">
        <location>
            <begin position="166"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="strand" evidence="6">
        <location>
            <begin position="176"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="helix" evidence="6">
        <location>
            <begin position="191"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="strand" evidence="6">
        <location>
            <begin position="195"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="strand" evidence="6">
        <location>
            <begin position="203"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="helix" evidence="6">
        <location>
            <begin position="209"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="helix" evidence="6">
        <location>
            <begin position="216"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="strand" evidence="6">
        <location>
            <begin position="223"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="231"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="strand" evidence="6">
        <location>
            <begin position="235"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="strand" evidence="6">
        <location>
            <begin position="246"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P15873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="7O1E"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="8Q7I"/>
        </source>
    </evidence>
    <sequence length="259" mass="28588" checksum="ACD98C1E223EA706" modified="2021-09-29" version="2">MLEARLEQASILKKVVDAIKDLVQDCNFDCNDSGIALQAMDNSHVALVSMMLKAEGFSPYRCDRNIALGVNLTSLTKVLRAAQNEDILTLKAEDAPDVLNLVFESSETDRISEYDLKLMDIDQEHLGIPETEYAATITMPSNEFKRITTDLMAMSESVTIEANKDGVKFSCQGDIGNGSVTLRQHTNVEKPNESIEIELSEPVSLTFSLKYLVNFCKASALSNTVKICLSNEVPLLVEYSLGGSSYLRFYLAPKIGDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFA0</accession>
    <name>G0SFA0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CTHT_0061310</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696447.1">
        <property type="nucleotide sequence ID" value="XM_006696384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFA0"/>
    <dbReference type="STRING" id="759272.G0SFA0"/>
    <dbReference type="GeneID" id="18260169"/>
    <dbReference type="KEGG" id="cthr:CTHT_0061310"/>
    <dbReference type="eggNOG" id="KOG0743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010189_4_2_1"/>
    <dbReference type="OMA" id="RCNPRYV"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="BCS1 N-terminal" evidence="15">
        <location>
            <begin position="74"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="321"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="389"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="525"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="420"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="525"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="549"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="563"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="607"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGS18116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="700" mass="77826" checksum="CA9AE568A4B26C39" modified="2011-10-19" version="1">MELGEFIRGALPSFFANTTMSSKKSAEYGSQDLPGGIIETLTPILGVQFNPLLRLVVVLNTMFGEYLGLDPTYVLVAYGCFWAIKRVWDFVYTNITYICQQYFQATVQVSSNDDIYVHFMKWLASQPSMVNSRSLTAETASKGAWDEEEDMDLVTTRVSPDGSNVYLNFSNQEAKAEPRFTPALGTHGFWFKGRYFTLHRRQEALYDAGAAYHGMPTFKDKEILVISCFGRSPEPIKELLRHVKAEFYRDHQAKTTVRRPASEIMRRYGSRHNWQQVANRPVRPMDTVVLDDEQKIRVLTDMNEYLHPSTPRWYANRGIPLRRGYLFHGPPGTGKTSLSFALAGVFGLDIYVISLLDPSLTEEDLLALFNGLPRRCVVLLEDIDTAGLKRNDQPASDESSSSSSSDDENTDEKDDESKEKKLKKSGKNKSKKNWKVSDLARELKRHGDSGEKKGISLSGLLNAIDGVASHEGRVLIMTTNKPEMLDEALIRPGRVDLQVAFTNATQKQARELFIRMYAPDSNMSSLLSHIPSNRTSPTKQSVVHTLGAPPSPPPTPPMSYPDKPSRIIDDSGSKTGDEVSSSSVPEITPTAPRAAKSNGTVTPPPSESDSPPSTPRTNSISGAFDDVEDEHPALLHPDVLARMADEFSAKIPPGQFSPAEVQGFLLKRKKTPRKALAEVDAWVQHMLAQKASKTKVLQVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFT2</accession>
    <name>G0SFT2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">5'-nucleotidase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0072030</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697465.1">
        <property type="nucleotide sequence ID" value="XM_006697402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFT2"/>
    <dbReference type="STRING" id="759272.G0SFT2"/>
    <dbReference type="GeneID" id="18261241"/>
    <dbReference type="KEGG" id="cthr:CTHT_0072030"/>
    <dbReference type="eggNOG" id="KOG4419">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005854_7_1_1"/>
    <dbReference type="OMA" id="NYDCDSP"/>
    <dbReference type="OrthoDB" id="7722975at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07409">
        <property type="entry name" value="MPP_CD73_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000020">
        <property type="entry name" value="NT5E isoform 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006146">
        <property type="entry name" value="5'-Nucleotdase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF24">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00786">
        <property type="entry name" value="5_NUCLEOTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005130829" description="5'-nucleotidase-like protein" evidence="6">
        <location>
            <begin position="18"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="7">
        <location>
            <begin position="46"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="5'-Nucleotidase C-terminal" evidence="8">
        <location>
            <begin position="346"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS17847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="569" mass="62858" checksum="BA7952B685C848BA" modified="2011-10-19" version="1">MIKHLLTAAFLAGGAIANIVQGKEDMLVSRRLSKRFYDDAGNYNISFYHINDVHAHLDQFSSSGTDCTKPEKGCYGGYARVKTVLKETRPSHPDSLLLNVGDEFQGTMFFTFYGGEKIAETLNHIGFDAMTLGNHEFDRGDDHLGEFLSNLTFPIVTANIITDHPVLNRTIKPYHIFPEYDLALIGVTTETIPDISQPGDGTKFTDPVQAVQATVDHIRATTNITRIAAITHIGYEEDQRLARETRGLYLIMGGHSHTPLGDFEGAEGPYPTIVENVDGEEIFIVTAYRWGEYLGYIDVTYAPDGRILAYHGAPIHLTNTTKQDEELQAMVDEWREPFEEFSKQEVGYSNVELDQSACQLKECLLGDFVADAMLQYRLNSSTAENSPDFALINAGGIRATIDAGPITRGEILTAFPFGNAIVEVPVSGERLWKVFEGIIAGLNVENGKAVTSFVQVSKGVVIKYKPDELQEGAGNYGKGKLVSVKINGKLLDKTKQYKIVTLDFIATGGDNFFSEKFDNLVLLDTLDEVVVKHIGAVSPVEIALEGRIKEVSDSCKKRRKARGLKKRAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0SG22</accession>
    <name>G0SG22_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ADP-ribosylhydrolase ARH3</fullName>
            <ecNumber evidence="2">3.2.1.143</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ADP-ribose glycohydrolase ARH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ADP-ribosylhydrolase 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">O-acetyl-ADP-ribose deacetylase ARH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Poly(ADP-ribose) glycohydrolase ARH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">[Protein ADP-ribosylarginine] hydrolase-like protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">[Protein ADP-ribosylserine] hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0064750</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>alpha-NAD(+) + H2O = ADP-D-ribose + nicotinamide + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68792"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57967"/>
            <dbReference type="ChEBI" id="CHEBI:77017"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ADP-ribosylglycohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.143" evidence="2"/>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696779.1">
        <property type="nucleotide sequence ID" value="XM_006696716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SG22"/>
    <dbReference type="GeneID" id="18260513"/>
    <dbReference type="KEGG" id="cthr:CTHT_0064750"/>
    <dbReference type="eggNOG" id="ENOG502SM6N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024566_8_0_1"/>
    <dbReference type="OMA" id="PQPRWID"/>
    <dbReference type="OrthoDB" id="2021138at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004649">
        <property type="term" value="F:poly(ADP-ribose) glycohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="entry name" value="ADP-ribosylation/Crystallin J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050792">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222">
        <property type="entry name" value="ADP-RIBOSYLGLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222:SF24">
        <property type="entry name" value="ADP-RIBOSYLHYDROLASE ARH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605502-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS17161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="356" mass="38635" checksum="4FECB22A9B59EB52" modified="2011-10-19" version="1">MSTPSLTRRDRILGALLGVHAGDSLGATLEFQGWWNIHCMFPNGLRDIIGGGHFSWPAGHATDDTDLTRAVLLAYRDVARAKKKGKENDVVKIAAEYMLDWLDGRDWPGRAKGSRPCDVGGATVEGLERYRQTRDPAAAGAGEGRAGNGSLMRCIPTGLFQREWGSLWDESVAISAVTHDDLVCTFSCAVYNTVVAALVEGKSVEEAFQAGIGAVRYTERLAGKEEDPVFRLKKERAIKKVEQALVTGRTLIKVDDLARNGPDGAKNVKKALPLAAKGFVLESLTIAIAALFDERSLEEILVDVVRFGGDSDTNGAIAGGLLGARDGVDAIPVRWREKLQFREEFEKVVDEILSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0SG23</accession>
    <name>G0SG23_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative cellulose binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0064760</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696780.1">
        <property type="nucleotide sequence ID" value="XM_006696717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SG23"/>
    <dbReference type="ESTHER" id="chatd-g0sg23">
        <property type="family name" value="Acetylxylan_esterase"/>
    </dbReference>
    <dbReference type="GeneID" id="18260514"/>
    <dbReference type="KEGG" id="cthr:CTHT_0064760"/>
    <dbReference type="eggNOG" id="ENOG502QUMZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040058_4_1_1"/>
    <dbReference type="OMA" id="FSCPNAD"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630:SF10">
        <property type="entry name" value="ACETYLXYLAN ESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="CUTINASE RV1984C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="250" mass="26528" checksum="5E4E127D94CC5C98" modified="2011-10-19" version="1">MILRSLTQQPQVPYNSTIPEANAMKITTLTFPVLASLARASPVEPRQSCPQVHIFGARETTVSQANGYGTTAGLVNMVKQAFPGATSEAIVYPACGGQASCGGISYDQSQWQGAEAVVRAVTDFNRRCPDTKIVLIGYSQGGQIFDNALCGGAGSTLSGSALQAVKAAILMGDPRYVAGLSYNVGTCQAQGFAARPRGFQCSPADPSIIQSYCDSTDPYCCNGYDANSHQQYVNKYGQQALEFIKRKLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0SG63</accession>
    <name>G0SG63_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chromatin assembly factor 1 subunit A dimerization domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0065180</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696820.1">
        <property type="nucleotide sequence ID" value="XM_006696757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SG63"/>
    <dbReference type="STRING" id="759272.G0SG63"/>
    <dbReference type="GeneID" id="18260556"/>
    <dbReference type="KEGG" id="cthr:CTHT_0065180"/>
    <dbReference type="eggNOG" id="ENOG502RY5G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013392_3_0_1"/>
    <dbReference type="OMA" id="YENVRPP"/>
    <dbReference type="OrthoDB" id="79480at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022043">
        <property type="entry name" value="CAF1A_DD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272:SF0">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A CAF-1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12253">
        <property type="entry name" value="CAF1A_dimeriz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromatin assembly factor 1 subunit A dimerization" evidence="6">
        <location>
            <begin position="353"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="496"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="127"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="507"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS17202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="602" mass="67184" checksum="6C46D283A5031988" modified="2011-10-19" version="1">MPTDSQSRDSSRKRSHGDFLNEDTSKSSPVKADASLSNKENQNPESATPRRKPENFDSGLTNPLEDLSSPEWKDEPMPDCPSSRASSPLSPPPATPSPLRPTSSSLKPTSGPNDGSGEPPKKKKRLTAAEKAAKAQAIEEEKRKRQEERERKRQEKEEAEKKKAAEKAARAAEKAEREQEKKQKQEERERKKREKEEEEAKKARSQLKLTSMFTKTTVPKPQSADNKMAKEGADAPKKEKTFYEQMFKPFFIKENVRMAPNYHEIDEETREAKAKALDEYLLNGRQEPLEKLDLCKTLGITTKRPRGRVYPSVRKIMTEFNQLTSGSIPNLSAERQNEKLRKTLEILKTVPVKSIKFKEDVRPPYIGTISGLPPGGQSLRKLARRPNSRNVLTLNYDYDSEAEWQDEEGEDIEDLDDEEEDIDMDDDMADFLDDSEDVGPQRKVLDADMEPQAIGPCFEDVSGRNPNPELHQYALEVLINIPEGHSIDPWSTAYWDSPKSKTKETASEASTSAASTSNSAAGASSSASAAQSSGPGRKKAQPLSAEMEEKLKDLVRSNPALSKLGIVEVFASQNPSCSRAQIKASFDLLFEKSGKGFKVKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0SG89</accession>
    <name>G0SG89_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L38-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0065470</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="476" last="476">
            <title>High-resolution structures of a thermophilic eukaryotic 80S ribosome reveal atomistic details of translocation.</title>
            <authorList>
                <person name="Kisonaite M."/>
                <person name="Wild K."/>
                <person name="Lapouge K."/>
                <person name="Ruppert T."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="35079002"/>
            <dbReference type="DOI" id="10.1038/s41467-022-27967-9"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.90 ANGSTROMS)</scope>
    </reference>
    <reference evidence="10 11 12" key="3">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e56910" last="e56910">
            <title>Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation during pre-60S biogenesis.</title>
            <authorList>
                <person name="Lau B."/>
                <person name="Huang Z."/>
                <person name="Kellner N."/>
                <person name="Niu S."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
                <person name="Cheng J."/>
            </authorList>
            <dbReference type="PubMed" id="37129998"/>
            <dbReference type="DOI" id="10.15252/embr.202356910"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <reference evidence="15 16 17" key="4">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e57984" last="e57984">
            <title>Structural insights into coordinating 5S RNP rotation with ITS2 pre-RNA processing during ribosome formation.</title>
            <authorList>
                <person name="Thoms M."/>
                <person name="Lau B."/>
                <person name="Cheng J."/>
                <person name="Fromm L."/>
                <person name="Denk T."/>
                <person name="Kellner N."/>
                <person name="Flemming D."/>
                <person name="Fischer P."/>
                <person name="Falquet L."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="37921038"/>
            <dbReference type="DOI" id="10.15252/embr.202357984"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.12 ANGSTROMS)</scope>
    </reference>
    <reference evidence="13 14" key="5">
        <citation type="journal article" date="2024" name="Nat. Commun." volume="15" first="716" last="716">
            <title>Methionine aminopeptidase 2 and its autoproteolysis product have different binding sites on the ribosome.</title>
            <authorList>
                <person name="Klein M.A."/>
                <person name="Wild K."/>
                <person name="Kisonaite M."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="38267453"/>
            <dbReference type="DOI" id="10.1038/s41467-024-44862-7"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.94 ANGSTROMS)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL38 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696846.1">
        <property type="nucleotide sequence ID" value="XM_006696783.1"/>
    </dbReference>
    <dbReference type="PDB" id="7OLC">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="Lk=1-94"/>
    </dbReference>
    <dbReference type="PDB" id="7OLD">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="Lk=1-94"/>
    </dbReference>
    <dbReference type="PDB" id="8I9X">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="Lk=1-94"/>
    </dbReference>
    <dbReference type="PDB" id="8I9Y">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="Lk=1-94"/>
    </dbReference>
    <dbReference type="PDB" id="8I9Z">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="Lk=1-94"/>
    </dbReference>
    <dbReference type="PDB" id="8IA0">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="Lk=1-94"/>
    </dbReference>
    <dbReference type="PDB" id="8ONZ">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.94 A"/>
        <property type="chains" value="Lk=1-94"/>
    </dbReference>
    <dbReference type="PDB" id="8OO0">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="Lk=1-93"/>
    </dbReference>
    <dbReference type="PDB" id="8PV1">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.56 A"/>
        <property type="chains" value="Lk=1-94"/>
    </dbReference>
    <dbReference type="PDB" id="8PV2">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.63 A"/>
        <property type="chains" value="Lk=1-94"/>
    </dbReference>
    <dbReference type="PDB" id="8PV3">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="Lk=1-94"/>
    </dbReference>
    <dbReference type="PDB" id="8PV4">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="Lk=1-94"/>
    </dbReference>
    <dbReference type="PDB" id="8PV5">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.86 A"/>
        <property type="chains" value="Lk=1-94"/>
    </dbReference>
    <dbReference type="PDB" id="8PV6">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.94 A"/>
        <property type="chains" value="Lk=1-94"/>
    </dbReference>
    <dbReference type="PDB" id="8PV7">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.12 A"/>
        <property type="chains" value="Lk=1-94"/>
    </dbReference>
    <dbReference type="PDB" id="8PV8">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.91 A"/>
        <property type="chains" value="Lk=1-94"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SG89"/>
    <dbReference type="EMDB" id="EMD-12976"/>
    <dbReference type="EMDB" id="EMD-12977"/>
    <dbReference type="EMDB" id="EMD-17003"/>
    <dbReference type="EMDB" id="EMD-17950"/>
    <dbReference type="EMDB" id="EMD-17951"/>
    <dbReference type="EMDB" id="EMD-17952"/>
    <dbReference type="EMDB" id="EMD-17953"/>
    <dbReference type="EMDB" id="EMD-17954"/>
    <dbReference type="EMDB" id="EMD-17955"/>
    <dbReference type="EMDB" id="EMD-17956"/>
    <dbReference type="EMDB" id="EMD-35287"/>
    <dbReference type="EMDB" id="EMD-35288"/>
    <dbReference type="EMDB" id="EMD-35289"/>
    <dbReference type="EMDB" id="EMD-35290"/>
    <dbReference type="SMR" id="G0SG89"/>
    <dbReference type="STRING" id="759272.G0SG89"/>
    <dbReference type="GeneID" id="18260585"/>
    <dbReference type="KEGG" id="cthr:CTHT_0065470"/>
    <dbReference type="eggNOG" id="KOG3499">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152057_1_0_1"/>
    <dbReference type="OMA" id="RCHRFIY"/>
    <dbReference type="OrthoDB" id="10250488at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022618">
        <property type="term" value="P:protein-RNA complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.90:FF:000001">
        <property type="entry name" value="60S ribosomal protein L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002675">
        <property type="entry name" value="Ribosomal_eL38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038464">
        <property type="entry name" value="Ribosomal_eL38_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01781">
        <property type="entry name" value="Ribosomal_L38e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8 9 10" id="KW-0002">3D-structure</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS17228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="7OLC"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="7OLD"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="8I9X"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="8I9Y"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="8I9Z"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="8ONZ"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="8OO0"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="8PV1"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="8PV2"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PDB" id="8PV3"/>
        </source>
    </evidence>
    <sequence length="94" mass="10878" checksum="46EFF4A8FC435A0B" modified="2011-10-19" version="1">MPQEVSDIKKFIEICRRKDASSKILTIAFPPPLTAARIKKNPKTQQIKFKVRCQRFLYTLVLKDSDKAEKLKQSLPPNLQIKDVPKRNKRKSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGB9</accession>
    <name>G0SGB9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carbohydrate kinase PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0065770</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696876.1">
        <property type="nucleotide sequence ID" value="XM_006696813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGB9"/>
    <dbReference type="STRING" id="759272.G0SGB9"/>
    <dbReference type="GeneID" id="18260615"/>
    <dbReference type="KEGG" id="cthr:CTHT_0065770"/>
    <dbReference type="eggNOG" id="KOG2947">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_3_1_1"/>
    <dbReference type="OMA" id="CNLATRK"/>
    <dbReference type="OrthoDB" id="204058at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052562">
        <property type="entry name" value="Ketohexokinase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42774:SF3">
        <property type="entry name" value="KETOHEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42774">
        <property type="entry name" value="PHOSPHOTRANSFERASE SYSTEM TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="3">
        <location>
            <begin position="133"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS17258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="262" mass="28681" checksum="60C492989E1A5B22" modified="2011-10-19" version="1">MKHLVLVGACYIDTILTSNDHENNNDDGGSDDVIDFSSCLFRDDHDQAAASWILRSDETNSRTIVNWNDLPEMTTDEFRGIVEGLKQQTNPAEDSANSEWWFHFEGRIPATTLQCMHYLRNAIPGCKISVEVEKPNREGLRDLASEADVVFYSKVWAESEGYSDPEACLRSEARSSKAVLTVCTWGADGAGSLISGGRYIHCPANRSGEQIKVVDTLGAGDTFIAGMLYALHTSATYDQALTFAVGLATKKVQQEGFAGLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGM1</accession>
    <name>G0SGM1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0066820</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10 11">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Vacuole membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696978.1">
        <property type="nucleotide sequence ID" value="XM_006696915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGM1"/>
    <dbReference type="STRING" id="759272.G0SGM1"/>
    <dbReference type="GeneID" id="18260720"/>
    <dbReference type="KEGG" id="cthr:CTHT_0066820"/>
    <dbReference type="eggNOG" id="KOG0232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085752_1_2_1"/>
    <dbReference type="OMA" id="MGVMKPD"/>
    <dbReference type="OrthoDB" id="1744869at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000001">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="15"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="92"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS17360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="162" mass="16417" checksum="022A89BBABA0EF02" modified="2011-10-19" version="1">MTDYCPVYAPFFGAMGCTAAIVFTCLGASYGTAKSGVGIAAMGVLRPDLIVKNIVPVIMAGIIGIYGLVVSVLISDGLTQDGYALYTGFIQLGAGLAVGLAGMAAGFAIGIVGDAGVRGTAQQPRLFVGMILILIFAEVLGLYGLIVALLMNSKATLNISCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGQ3</accession>
    <name>G0SGQ3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BAH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0067170</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697010.1">
        <property type="nucleotide sequence ID" value="XM_006696947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGQ3"/>
    <dbReference type="STRING" id="759272.G0SGQ3"/>
    <dbReference type="GeneID" id="18260755"/>
    <dbReference type="KEGG" id="cthr:CTHT_0067170"/>
    <dbReference type="eggNOG" id="KOG0955">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045135_0_0_1"/>
    <dbReference type="OMA" id="KCQIRHA"/>
    <dbReference type="OrthoDB" id="336088at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048189">
        <property type="term" value="C:Lid2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036205">
        <property type="term" value="P:histone catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.490:FF:000018">
        <property type="entry name" value="Lid2 complex component snt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029617">
        <property type="entry name" value="Snt2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47672">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SNT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47672:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SNT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAH" evidence="2">
        <location>
            <begin position="311"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="478" mass="50659" checksum="8E9FF52F80143B35" modified="2011-10-19" version="1">MAHKSQSQSANHHTPDDQGQGTITTSNSGPAAPSSSIASSVLPRMSDPTSAASASSANSNSNDSTSSSASSAQSSTMEKSSASGSQASPYGTRSRNRNGAPRPNYAEDKDFDFDIFDDDSNSSTSKKSSSKKDKDKDALSAAPSTASSSAGQSTNATSSSSSSSSSSSSSSSSSSSSSSSSSQSKSGSGSSRKPLPSESKQSTSAQNGTKEQSQGPSASSSSSSTANGTTSGPSKGKKRKATDSATPSGTQTPSGSTGSSGSSALQKRLAGNGLGSDRSLYKGYPESNMLTFEKCKGRPTKDGKMVADDGTVLSVNDHVYLVCEPPGEPYYLGRIMEFLHVKNDPTQPVDAIRVNWYYRPKDIGRKVQDTRLVFATMHSDISPLTALRGKCQIMHKTEIPDLAAYKRQPDCFWYEKLYDRYIQKNYEVIPTKLVINVPEHVKKVLDERWKYVLTEQGRGKELTSAVKTCKRCSTYCAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGS5</accession>
    <name>G0SGS5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trimethylguanosine synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cap-specific guanine-N(2) methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0067390</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78479"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="Rhea" id="RHEA-COMP:19089"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:78480"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="Rhea" id="RHEA-COMP:19090"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:78508"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78471"/>
            <dbReference type="Rhea" id="RHEA-COMP:19085"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:78472"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78475"/>
            <dbReference type="Rhea" id="RHEA-COMP:19086"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78476"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697032.1">
        <property type="nucleotide sequence ID" value="XM_006696969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGS5"/>
    <dbReference type="SMR" id="G0SGS5"/>
    <dbReference type="STRING" id="759272.G0SGS5"/>
    <dbReference type="GeneID" id="18260777"/>
    <dbReference type="KEGG" id="cthr:CTHT_0067390"/>
    <dbReference type="eggNOG" id="KOG2730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029658_3_1_1"/>
    <dbReference type="OMA" id="KALCIYY"/>
    <dbReference type="OrthoDB" id="194443at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071164">
        <property type="term" value="F:RNA cap trimethylguanosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019012">
        <property type="entry name" value="RNA_cap_Gua-N2-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741:SF32">
        <property type="entry name" value="TRIMETHYLGUANOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09445">
        <property type="entry name" value="Methyltransf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS17414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="255" mass="28178" checksum="A8B0075CD54077DF" modified="2011-10-19" version="1">MVVSSFSASGKLYFHQRHSLFLHYAYDIRLTPSAWFGVTPEPIARRIAADIPSHLGSTPSKDTIVDLFAGAGGNTIAFALAEKWARIIAIEKDPATLACAQHNAAVYGVSECITWVLGDSMEYLSRLRRARLEGKPPEEVGVDDRLWLDPARTVLFASPPWGGVGYREQEVFDLEGMQPYGLRMLHGMCWEMEHVLYLPRTSDLRQIAALVGDGEDRKIECVQYCMDGASKALVAYIPAERGDQDQDGGGGRSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2023-02-22" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGS7</accession>
    <name>G0SGS7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0067410</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697034.1">
        <property type="nucleotide sequence ID" value="XM_006696971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGS7"/>
    <dbReference type="GeneID" id="18260779"/>
    <dbReference type="KEGG" id="cthr:CTHT_0067410"/>
    <dbReference type="HOGENOM" id="CLU_1618814_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS17416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="164" mass="18074" checksum="91A2CE6EB754EC3F" modified="2011-10-19" version="1">MPADSDVANLDLAPAFHASEIMQRLRDELSPPAVERLRSSFIKLSSSVTRDQLLSSGRQRRYCASAARQAVGSLWDREHLPSPRGEMAGRASPADWTGRVQAVRGRQGRFDSLNGRFLGLKTATFDGASRSIAPAWDEQDPDSLIMRHWESEVKIRMIGPGGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGT9</accession>
    <name>G0SGT9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Multiple myeloma tumor-associated protein 2-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0067540</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697046.1">
        <property type="nucleotide sequence ID" value="XM_006696983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGT9"/>
    <dbReference type="GeneID" id="18260792"/>
    <dbReference type="KEGG" id="cthr:CTHT_0067540"/>
    <dbReference type="eggNOG" id="KOG4520">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061193_3_3_1"/>
    <dbReference type="OMA" id="THHRVDR"/>
    <dbReference type="OrthoDB" id="5390672at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019315">
        <property type="entry name" value="MMTA2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039207">
        <property type="entry name" value="MMTAG2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14580:SF0">
        <property type="entry name" value="MULTIPLE MYELOMA TUMOR-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14580">
        <property type="entry name" value="MULTIPLE MYELOMA TUMOR-ASSOCIATED PROTEIN 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10159">
        <property type="entry name" value="MMtag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Multiple myeloma tumor-associated protein 2-like N-terminal" evidence="2">
        <location>
            <begin position="11"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="285" mass="34383" checksum="2CED9C89EE76260B" modified="2011-10-19" version="1">MDLLSTVRKTGSRGGVNFSWDDVANSQYRENYLGHSIKAPVGRWARGRDLFWYTKADPPPASAAETEEEKAARERAEEIRRLKEAEEEAMARALGLPIPAKKVTGANAVEIAPRREKGKGEEEGDGKKTEKNVNVKEERGERHKDSEHRHRRRHRSRSRDRDRSRERERGRDRDRERERDSGRERSRSRHRRRDGSVSDIDRDRRHRRRSRSPERDRHRGEKRREDRLDDVRDRYHTRKDRETKRYSRSRSRSRSRSRDRLRSERFDRRRSRSRSHSKTRYRDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGU5</accession>
    <name>G0SGU5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0067600</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697052.1">
        <property type="nucleotide sequence ID" value="XM_006696989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGU5"/>
    <dbReference type="STRING" id="759272.G0SGU5"/>
    <dbReference type="GeneID" id="18260798"/>
    <dbReference type="KEGG" id="cthr:CTHT_0067600"/>
    <dbReference type="eggNOG" id="KOG0435">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004427_2_0_1"/>
    <dbReference type="OMA" id="GIEHACM"/>
    <dbReference type="OrthoDB" id="15954at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00812">
        <property type="entry name" value="LeuRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000003">
        <property type="entry name" value="Leucine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000338">
        <property type="entry name" value="Leucine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000034">
        <property type="entry name" value="Leucine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00049_B">
        <property type="entry name" value="Leu_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025709">
        <property type="entry name" value="Leu_tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00396">
        <property type="entry name" value="leuS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740:SF2">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13603">
        <property type="entry name" value="tRNA-synt_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="13">
        <location>
            <begin position="80"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Leucyl-tRNA synthetase editing" evidence="14">
        <location>
            <begin position="265"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="472"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="676"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="12">
        <location>
            <begin position="780"/>
            <end position="901"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS17434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="941" mass="105572" checksum="DB9E0BFCA01BA8E8" modified="2011-10-19" version="1">MLLLTQAKSIGRLARPLSRSLYSGLIPLRPWARPFTITSRAAAKLDLPALDLKWRKRWAQLQQVQKDKTKDKVDKYILPMFPYPSGYLHLGHLRVYTIADAIARYNALRGHNVLLPMGWDAFGLPAENAAIERSINPATWTKDNIARMKEQLQMMNGSWDWEREIATCDPSFYKHTQKIFLLLHQHGLAYRTEAEVNYDPVDKTVLANEQVDANGCSWRSGAKVEKRKLNQWFLRISAFREALLDDLELLAKDEAWPERVLAMQRNWLGKSKGATIKFPILAYDQDVHAAIEVYTSRPDTLFGVQYLALAATHPIVTKLAETDPELQAFLDTLPGLPPDSKVGYMLPHIRAINPLAYHPDTPDATKQSLPIYVAPYVIGDYGEGAVMGVPAHDARDHAFWRTHRGDEPVRYVLASNEDESTTVIPNEPFLDHGIMTAHSGPYKGKPSQEAGEMLVKMLAEAGLAKPVEKWRLRDWLISRQRYWGTPIPIVHCASCGEVPVPDEQLPVLLPEVDAHWAGKKTGNPLETLDEWVNTECPKCHGPAKRDTDTMDTFVDSSWYYMRFIDPHNEAGPFDPQKARDMLPVDIYIGGIEHAILHLLYARFIYKFLMTSPLFPTSSASERHEPFKRLITQGMVHGRTFTDPATGRFLKPDELDLSDPANPRIKATGTKPNVTYEKMSKSKHNGVDPTAVIATHGADATRAHMLFQAPVGDVLDWDGDKIVGVTRWLSRVHDLVEKVTSTAPSPDYDFPTPKAYFESLAPRLSSLGEAELKQYDANSALWRTTQTTIASVSQSYEKVYPLNTVISDLMQLTNTLSDTLSCATPQIAREAVSILIRLMAPVTPAVAEECWSVLEPTSSGLFASEEGARWPERDGSEAVLRERKMKCAVQVNGKVRAVCEIGIAPEGLEGDKLREFVVGEIMKQDEHRQSLTRLTETASDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGZ1</accession>
    <name>G0SGZ1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylserine decarboxylase proenzyme 1, mitochondrial</fullName>
            <ecNumber evidence="12">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 1 beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 1 alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="12" type="primary">PSD1</name>
        <name evidence="14" type="ORF">CTHT_0068070</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="12">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Phosphatidylserine decarboxylase 1 alpha chain</molecule>
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Intermembrane side</orientation>
        </subcellularLocation>
        <text evidence="12">Anchored to the mitochondrial inner membrane through its interaction with the integral membrane beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Phosphatidylserine decarboxylase 1 beta chain</molecule>
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
            <topology evidence="12">Single-pass membrane protein</topology>
            <orientation evidence="12">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="12">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="12"/>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697098.1">
        <property type="nucleotide sequence ID" value="XM_006697035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGZ1"/>
    <dbReference type="STRING" id="759272.G0SGZ1"/>
    <dbReference type="GeneID" id="18260845"/>
    <dbReference type="KEGG" id="cthr:CTHT_0068070"/>
    <dbReference type="eggNOG" id="KOG2420">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029061_1_1_1"/>
    <dbReference type="OMA" id="HSPASWV"/>
    <dbReference type="OrthoDB" id="4330at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03208">
        <property type="entry name" value="PS_decarb_PSD_B_type1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033661">
        <property type="entry name" value="PSD_type1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF6">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023387767" description="Phosphatidylserine decarboxylase 1 beta chain" evidence="12">
        <location>
            <begin position="1"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023387768" description="Phosphatidylserine decarboxylase 1 alpha chain" evidence="12">
        <location>
            <begin position="470"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial matrix" evidence="12">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial intermembrane" evidence="12">
        <location>
            <begin position="82"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="276"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="470"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="12">
        <location>
            <position position="470"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="12">
        <location>
            <begin position="469"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="12">
        <location>
            <position position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS17480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="514" mass="58062" checksum="4A1D6D75CD2FB190" modified="2011-10-19" version="1">MASFQIGPVSTAVGHHRHFHSSFYSRRVYLRPRLLGRRSYSKEHSHGPEASSKVNGSRIRWYPIPVGLGVGFLGLVQVYKVYSREQEQKVENARPKRRRVRPDGPWQVQIMSTLPLKAMSRLWGRFNELTLPTFLRAPGFRLYSWIFGVNLDEIAEPDLRKYPNLAAFFYRQLKPGARPLDPNPNALLSPSDGRILQFGQIEGGDIEQVKGMTYTIDALLGRNSRTPSVSSSTSLDSLAIESVHELEGDEELVKRDEEFARMNGISYTLPSLLSGDKKQRRDSMDKHPKDESITPSPASVSEVRAELALGEKPWHDYLTNSSHHRLYYAVIYLAPGDYHRFHSPTNWVVERRRHFAGELFSVSPYLQRTLPGLFTLNERVVLLGRWRWGFFSYVPVGATNVGSIKINFDKELRTNSLTADTQAARDAEEAAKRGEPYLGYAEATYEAASPVLHGYALRRGEEMGGFQLGSTIVLVFEAPASEHDESGRHVAGWKWSVEKGQRVKVGQALGHVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHA4</accession>
    <name>G0SHA4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0069300</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Plays a key role in the late stages of endoplasmic reticulum to Golgi traffic.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the multisubunit TRAPP (transport protein particle) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697211.1">
        <property type="nucleotide sequence ID" value="XM_006697148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHA4"/>
    <dbReference type="STRING" id="759272.G0SHA4"/>
    <dbReference type="GeneID" id="18260968"/>
    <dbReference type="KEGG" id="cthr:CTHT_0069300"/>
    <dbReference type="eggNOG" id="KOG3315">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073154_2_1_1"/>
    <dbReference type="OMA" id="YMVKFDD"/>
    <dbReference type="OrthoDB" id="10254842at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990070">
        <property type="term" value="C:TRAPPI protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14943">
        <property type="entry name" value="TRAPPC5_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000007">
        <property type="entry name" value="Trafficking protein particle complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016696">
        <property type="entry name" value="TRAPP-I_su5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902">
        <property type="entry name" value="41-2 PROTEIN ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017479">
        <property type="entry name" value="TRAPP_I_complex_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS17593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="219" mass="24429" checksum="91CACEE1EDCD52F1" modified="2011-10-19" version="1">MSHLGPGSKLASSKEQAGLRYPSNGKTIYHRPLNRSKTAELSQAAFAYLFSEMVSYAQKRSTGIQELEKRLNEQGHPIGLKLLDLLLIREPARSQNRPLNIIALLHFIKINVWTHLFGRQADRLEKSSNPDTPDEYMIIDNEPLVNAYISVPREMNQLNCAAYVAGIIEGVCDGAMFPARVTAHTVGGKEEGEMWPGKTVFLVKFQPEVLEREALLGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHP6</accession>
    <name>G0SHP6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ubiquitin-protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0072900</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS16966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697548.1">
        <property type="nucleotide sequence ID" value="XM_006697485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHP6"/>
    <dbReference type="STRING" id="759272.G0SHP6"/>
    <dbReference type="GeneID" id="18261328"/>
    <dbReference type="KEGG" id="cthr:CTHT_0072900"/>
    <dbReference type="eggNOG" id="KOG2166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004747_7_1_1"/>
    <dbReference type="OMA" id="MFKDMTI"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000001">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000002">
        <property type="entry name" value="cullin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000061">
        <property type="entry name" value="Related to cullulin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000036">
        <property type="entry name" value="SCF ubiquitin ligase subunit CulC, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000011">
        <property type="entry name" value="SCF ubiquitin ligase subunit CulC, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="6">
        <location>
            <begin position="451"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS16966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="840" mass="97065" checksum="9296277245D14988" modified="2011-10-19" version="1">MSARPNKTRPIRRPIVSRDTADFDVCWETLRNAITDIHNKNSSQLSFESLYRASYKIVIKKQGQRLYEKVKELEEEWFRVNVLPRVAELVNNNLLSVALVRMPGRSNNERREMGEKVLRGIHREWEDHNVSMNMVADILMYLERTYTAEAKQPSIFAVTIGLFRDHILRNTLSNEALLPGQTFDIFEVIIQILLDFIHMEREGDVVDRNLMRQITAMLEDLYETDDELTNAKLYLTVFEPRFLRASRDFYRSECEKLLREGDARAWLRHTQRRLREELERCTTSLSTLTTENITRVVEQELISAKLDEFLALEGSGMKAMIDDDRYEDLEILYDLVSRVDKTKNALKGILQKRVMDLGLEIEKTLKNTDFSVPAAGASADGEEAAEGGDKAKAQPLNAAAQQTAAAIKWVDDVLRLKDKFDTILSRCFKDDLILQSAITKSFSDFINMFSRSSEYVSLFIDDNLKRGLKGKSEEEVETVLQKAIVLLRYLSDKDMFERYYQKHLARRLLHNKSEMHTEKELVRRMRTEMGNHFTQKFEGMFKDMELSKDLSQSYRDHVRNLGDTETKTIELGIHVLTSNNWPPEVMGRNATQTGEGTRADCIYPPEIKRLQESFYKFYLKDRSGRVLTWVGTAGTADIKCIFPKIPGKENGPLSKERRYELNVSTYGMVVLMLFNDLADGEWLTFEEIQTKTNIPQQDLIRTLSSLSIPSKSRVLLKEPLTKSVKTTDKFAFNAQFVSKTIKIKAPVVSSTNKVEGDEERKETERKNDQTRAHVVDAAIVRIMKQRKELTHTQLTTEVIAQLAGRFKPDISMIKKRIEDLLIREYIERIDGETAAYRYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHZ4</accession>
    <name>G0SHZ4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0073920</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697646.1">
        <property type="nucleotide sequence ID" value="XM_006697583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHZ4"/>
    <dbReference type="STRING" id="759272.G0SHZ4"/>
    <dbReference type="GeneID" id="18261430"/>
    <dbReference type="KEGG" id="cthr:CTHT_0073920"/>
    <dbReference type="eggNOG" id="ENOG502RXTA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014722_0_2_1"/>
    <dbReference type="OMA" id="FMGANNI"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF13">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1996" evidence="1">
        <location>
            <begin position="8"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="280" mass="31562" checksum="705EBBD22706D9C6" modified="2011-10-19" version="1">MPYPQHDPAEKSTCTSCQFAEDLSNYWTAVLFFRARNGTFKRVPQLAQFDMQGQNGGMVVYYMSDALFDTNQRSKVTAFRPGFRMIVGDATFSTREQAREFRQITYTCMESQMSRAPETVGFPKTPCKLGIMANHRFPTCWDGVNLDTPNHRDHVAYPESGTFESGGPCPASHPVRIPQILLETIWDTSQFNNKDDWPEDGSQPFVWSNGDSTGYSSHADYVFGWKGDSLQRAMDAHTYVVAPMLKSQSIAEQNRCTVPDMVGESFDGWLKELPGGNPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0SI68</accession>
    <name>G0SI68_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CTHT_0074700</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to direct preproteins in transit and direct them to the channel protein TIM23, and possibly facilitates transfer of the translocating proteins from the TOM complex to the TIM23 complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21. Interacts with preproteins in transit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion inner membrane</location>
            <topology evidence="1 15">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the TIM50 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697720.1">
        <property type="nucleotide sequence ID" value="XM_006697657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SI68"/>
    <dbReference type="SMR" id="G0SI68"/>
    <dbReference type="STRING" id="759272.G0SI68"/>
    <dbReference type="GeneID" id="18261508"/>
    <dbReference type="KEGG" id="cthr:CTHT_0074700"/>
    <dbReference type="eggNOG" id="KOG2832">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023309_0_0_1"/>
    <dbReference type="OMA" id="NLRQPYT"/>
    <dbReference type="OrthoDB" id="287041at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000019">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit TIM50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 15" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10 15" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FCP1 homology" evidence="18">
        <location>
            <begin position="229"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="37"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="113"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="476"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGS17138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="525" mass="59661" checksum="76F00A4F9C3933D6" modified="2011-10-19" version="1">MLSRAAMGPLGLRAAALASSSTIRSCAVPAVWSRCMSATRDSKSRFSKPQNPPAQKPSQPASKPSPEPSQDAPAQPSAEKETTHDAPQEEIPDLSKLPDLTQGIPSTLEYETAGATDKSSLHPSEEEPPKTGGKRPKGELPASAYVSSTERRRQKMAWWAFALTGVFTVAGTVYLGRNWSEEELAKNPEVPNGWSLTLWWKRAMARMTDTVEYYQEPAFEKLLPDPDPSFERPYTLVISLEDMLVHSEWTREHGWRIAKRPGVDYFLHYLSQYYEIVLFTTVPFATGEPLVRKLDPYRFIMWPLFREATKYQDGEIVKDLSYLNRDLSKVIIIDTNPKHVRAQPENAIILPKWTGDPKDKELVSLVPFLEFIHAMQYSDVRKVLKSFEGTHIPTEFARREAIARAEHNKRIQAKARQSGMSWLSSHLGLKPSSMSLMVAPEGEEDPQEAFAKGKMLHDIARERGIRNYLMLEEEIRKNGEKWLKEEQEAMERAQKEAMKNMKSSFFGWFTPSEKEESVSTQSKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>G0SI71</accession>
    <name>G0SI71_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0074730</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697723.1">
        <property type="nucleotide sequence ID" value="XM_006697660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SI71"/>
    <dbReference type="GeneID" id="18261511"/>
    <dbReference type="KEGG" id="cthr:CTHT_0074730"/>
    <dbReference type="eggNOG" id="ENOG502SBVF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063948_0_0_1"/>
    <dbReference type="OMA" id="NTAHINP"/>
    <dbReference type="OrthoDB" id="10010954at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409194" evidence="1">
        <location>
            <begin position="25"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="313" mass="34818" checksum="4B8D943F66A98154" modified="2011-10-19" version="1">MFRPNFILLALGWALLQQVHLANAWPTPHQLSQWLPHFKSQRPQTQPDFARRNFETMSRIYNLTVYPNQLPILGGGGAAAPPGLFTQDVRGRVTPVGDFEDFEHSIEYFFSLSPVPQGNAVKGAITGYRIVEFSSQCPEIAASVVYLYCSVVDPGSPDHGRPLPALKQVAFWRFDSQGTVAYYDAWIPNLHSWVELTNGGVPVSDPQFQASSITQICTLTQLRCHGENRQWDSIEQCIADLSQKPYGNYDEAWGDNIACRSIHLVLTQVRPDVHCPHVGPTGGGKCVNAPYAERYFSDESLFGSPSGETFVCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G0RXT6</accession>
    <name>G0RXT6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0000330</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988030">
        <property type="protein sequence ID" value="EGS24102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690588.1">
        <property type="nucleotide sequence ID" value="XM_006690525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RXT6"/>
    <dbReference type="GeneID" id="18254071"/>
    <dbReference type="KEGG" id="cthr:CTHT_0000330"/>
    <dbReference type="HOGENOM" id="CLU_1758591_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408617" evidence="2">
        <location>
            <begin position="19"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS24102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="148" mass="16702" checksum="034536DDF91CCF27" modified="2011-10-19" version="1">MKLSTVYTLSAIFLGVMGMPRGSPHHFENHNLASSRRSAGPVAWYDNIRNVTCSGDKGSGKILCVKGVEDFLLNAQLEVEGDSVSESDSEDSSEEEEDGNNEESEDSDSDSEEEEDEEEERKKKRRRRRRRLSLRNFTCRTIESGPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G0RY24</accession>
    <name>G0RY24_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase II holoenzyme cyclin-like subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0005140</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691052.1">
        <property type="nucleotide sequence ID" value="XM_006690989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RY24"/>
    <dbReference type="SMR" id="G0RY24"/>
    <dbReference type="STRING" id="759272.G0RY24"/>
    <dbReference type="GeneID" id="18254552"/>
    <dbReference type="KEGG" id="cthr:CTHT_0005140"/>
    <dbReference type="eggNOG" id="KOG0794">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034754_2_0_1"/>
    <dbReference type="OMA" id="CLLHPPH"/>
    <dbReference type="OrthoDB" id="10266018at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20513">
        <property type="entry name" value="CYCLIN_CCNC_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20546">
        <property type="entry name" value="CYCLIN_SpCG1C_ScCTK2-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028758">
        <property type="entry name" value="Cyclin, C/H/G types"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0195">Cyclin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="53"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="268"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS23810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="355" mass="39212" checksum="05F093A8F346C13C" modified="2011-10-19" version="1">MAANYWESTQRKFWQFTKEELAAIRQRLDDADKELVQMFPLPQMRHLNIYFNQQINRLGKRLGVRQQGMATAQVYIKRFYTRVQIRHTNPYLVITTALYLACKMEECPQHIRLLTQEARSLWPSDLHGHDASRVGECEFSLISEMNSQLIVHQPYRTLLAVQEEFGLTHDETALAWTVINDHYMTDLPLLHPPHIVAFTAILLALVLRPSGGSGSRDSSTGPGPAGTGSAVGVATGPNAPQGVALAASALAQAQAQQAQARAAVMAGGSQGADGMGGASGVGQAAGSEQPKKATDPRLAKVQRFAQWLADSNIDIDAMVDCTQELISFYECHEQYNDKHTREQISRFIKARGLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>G0RY85</accession>
    <name>G0RY85_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0005790</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691113.1">
        <property type="nucleotide sequence ID" value="XM_006691050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RY85"/>
    <dbReference type="GeneID" id="18254617"/>
    <dbReference type="KEGG" id="cthr:CTHT_0005790"/>
    <dbReference type="HOGENOM" id="CLU_2263452_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="103" mass="10227" checksum="2965F7816E252CDE" modified="2011-10-19" version="1">MSSGGGAVGGGPVGGGNLQDVNASQSDQVIASSSAAARGSVGAGWGGGYFRFDCIFRHLGCDSKIYTGNTACQLCVAMGLVGMGGRPTPPPQEPSSDQPPPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYJ3</accession>
    <name>G0RYJ3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0006900</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691221.1">
        <property type="nucleotide sequence ID" value="XM_006691158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYJ3"/>
    <dbReference type="GeneID" id="18254728"/>
    <dbReference type="KEGG" id="cthr:CTHT_0006900"/>
    <dbReference type="HOGENOM" id="CLU_157377_0_0_1"/>
    <dbReference type="OrthoDB" id="2251794at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408639" evidence="1">
        <location>
            <begin position="17"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="101" mass="11104" checksum="804A441000F28AAF" modified="2011-10-19" version="1">MRPLAFLLLFNPITLAKIGGRCHGSWNTDNCICHDVTECQKYYGTPEPGDTGNWPCPDDPANMQACFVRGCDYRGSNACSYCACQCSEAMGFWKINAAVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYK9</accession>
    <name>G0RYK9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Endodeoxyribonuclease-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0007060</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691237.1">
        <property type="nucleotide sequence ID" value="XM_006691174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYK9"/>
    <dbReference type="STRING" id="759272.G0RYK9"/>
    <dbReference type="GeneID" id="18254744"/>
    <dbReference type="KEGG" id="cthr:CTHT_0007060"/>
    <dbReference type="eggNOG" id="KOG3020">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031506_1_0_1"/>
    <dbReference type="OMA" id="YGGSQKH"/>
    <dbReference type="OrthoDB" id="6079689at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050891">
        <property type="entry name" value="TatD-type_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060:SF15">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060">
        <property type="entry name" value="TATD FAMILY DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="108"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="325"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS23995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="412" mass="45562" checksum="3FD9B5994530AEE4" modified="2011-10-19" version="1">MAETSQTVSESASQADLAPSLPAYRPRYIDIGINLADPIFRGRYHGKQKHPDDLKGVVDRAIEVGCTKLIVTGSSFKSTRDALKLCREFPGTVYATAGIHPCSSSIFSRGHHKHHDESESEGEAEHTPQCDPDPTKPIQDGSDGGVCQERSERIIADLTTLINESRANNPGDLVAFGEFGLDYDRLHYCSKEVQLHSFRVQLQLAASLSPQLPLFLHSRAAHADFVRLLKEAFGEKLEKLEKGGVVHSFTGTVEEMKELMDLGLYIGINGCSFKTAENCAVVKEVALDRLMIETDGPWCEVRPSHEGWKYLVEWEKTAAAATPCGAATTQAVEPEKQKQQGKKNQKKEPEVPERFKTVKKEKWEEGAMVKGRNEPCMIERVAKIIAAIKGVSLEEVCEASWANTVKVFGLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYT9</accession>
    <name>G0RYT9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mannan endo-1,4-beta-mannosidase A</fullName>
            <ecNumber evidence="4">3.2.1.78</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Endo-beta-1,4-mannanase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0000550</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random hydrolysis of (1-&gt;4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.</text>
            <dbReference type="EC" id="3.2.1.78"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.78" evidence="4"/>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690609.1">
        <property type="nucleotide sequence ID" value="XM_006690546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYT9"/>
    <dbReference type="SMR" id="G0RYT9"/>
    <dbReference type="STRING" id="759272.G0RYT9"/>
    <dbReference type="GeneID" id="18254093"/>
    <dbReference type="KEGG" id="cthr:CTHT_0000550"/>
    <dbReference type="eggNOG" id="ENOG502QS4Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031603_4_0_1"/>
    <dbReference type="OMA" id="YHDGFSI"/>
    <dbReference type="OrthoDB" id="406631at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046355">
        <property type="term" value="P:mannan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000076">
        <property type="entry name" value="Mannan endo-1,4-beta-mannosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045053">
        <property type="entry name" value="MAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451:SF21">
        <property type="entry name" value="MANNAN ENDO-1,4-BETA-MANNOSIDASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26410">
        <property type="entry name" value="GH5_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408647" description="Mannan endo-1,4-beta-mannosidase A" evidence="11">
        <location>
            <begin position="21"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="12">
        <location>
            <begin position="34"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF26410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS23367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="413" mass="46763" checksum="F8D516B6573A0040" modified="2011-10-19" version="1">MHLLTCKLLATSLLVTTAYGLPGIHANARKDPRFVTVEGERFKLNGRDFHFAGSNAYYFPFNADQADIEKGLLAAKNAGLTVFRTWGFNDKNSSYIPGGLPQYGGEGAGPSEVVFQWWHPNGTSTINVAGFDKVVNAAIKTDMKLIVALTNNWADYGGMDVYTVNLGGRYHDDFYRLPKIKSAFKRYVKTIVTRYKDSPAILAWELANEPRCGADGVRNLPRSPDCTPAVLSAWIAEMSAYIKSLDPNHLVTWGGEGGFNRESDDWAYNGADGGDFDHELSLKTIDFGTFHSYPDWWSKTTDWTEQWIRDHAAAGRRARKPVVHEEYGWLTPELRLEYTGRVDNRTRVEVMGRWQKITVAEKLAGSMYWQYGYSNYSYGRNHNDGFTIYLDDSEAQVLVYQHAKEMNALNRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZ53</accession>
    <name>G0RZ53_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Queuosine 5'-phosphate N-glycosylase/hydrolase</fullName>
            <ecNumber evidence="6">3.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 6">Queuosine-nucleotide N-glycosylase/hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0001740</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>queuosine 5'-phosphate + H2O = queuine + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:75387"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17433"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:194371"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5 6">
            <dbReference type="Rhea" id="RHEA:75388"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the QNG1 protein family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="6"/>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690723.1">
        <property type="nucleotide sequence ID" value="XM_006690660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZ53"/>
    <dbReference type="STRING" id="759272.G0RZ53"/>
    <dbReference type="GeneID" id="18254212"/>
    <dbReference type="KEGG" id="cthr:CTHT_0001740"/>
    <dbReference type="eggNOG" id="KOG2524">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036001_2_1_1"/>
    <dbReference type="OMA" id="FSFWSEE"/>
    <dbReference type="OrthoDB" id="416777at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019438">
        <property type="entry name" value="Q_salvage"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21314:SF0">
        <property type="entry name" value="QUEUOSINE 5'-PHOSPHATE N-GLYCOSYLASE_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21314">
        <property type="entry name" value="QUEUOSINE 5'-PHOSPHATE N-GLYCOSYLASE_HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10343">
        <property type="entry name" value="Q_salvage"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS23481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="380" mass="43705" checksum="20EEFCD772393448" modified="2011-10-19" version="1">MSDDEADPSLLEFLRQHLQGKLSLNSPDDDDVSPDTGVLTDAEWVYDHGAIDVALDMRSCKAAAELIYTQMQQRGYSPATWVSAHELHPDPKMLGEGKTVAFIFVMDLLNFSFWSEKGEEERFAVEYKGRRWTGYWSLVAGLRRALDEGIPITDPYFWTDDLEFTVDTLRQVFRSCTDEEMPLLTERFDCLREAGQVLCNKYDADPLNLVKAAKGSATRLVNLLARDFSCFRDEHNFEVEGRTKRIRIMKRAQILVADLWACFEGAGPGEFRDIDKITMFADYRVPQILNSMNCLIYSPTLEGAIKDKKEIASGSSWEIQLRVACSIWCVELIRREILRQHPGTKINAVLIDFYLYDAMKEMEAQGKERLPHHRTRSIWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZ98</accession>
    <name>G0RZ98_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bms1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0002200</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690768.1">
        <property type="nucleotide sequence ID" value="XM_006690705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZ98"/>
    <dbReference type="STRING" id="759272.G0RZ98"/>
    <dbReference type="GeneID" id="18254258"/>
    <dbReference type="KEGG" id="cthr:CTHT_0002200"/>
    <dbReference type="eggNOG" id="KOG1980">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009858_1_0_1"/>
    <dbReference type="OMA" id="MNLPRFK"/>
    <dbReference type="OrthoDB" id="119302at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF1">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22298">
        <property type="entry name" value="Tsr1_G-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="6">
        <location>
            <begin position="89"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="406"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="406"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS23526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="830" mass="93625" checksum="06EA4A5CAE15A48C" modified="2011-10-19" version="1">MPGPVSNGQHHHRPTTKTKHKPFKSRHATKRALRDAAKGRVPNEKGQRKTPHQQVMSKLDRRNQAKQRLLEKSREHAKEVSVFNGRDGAPRNVAVIPLCPDTDAVAAIKALNDSIDIEADVRDGVFRVPVDRFKQKLQYIALNRDLTACLDACSVADFIVLVLSAHVEVDELGELILRSVESQGMSTLFTVVQGLNRIEPQKQRLSVVASLKSYITHFHPEQEKIYNLDNRQECSNLMRSLCSTTPKGVRWRDERSWMLIEDVKFGASADEPSIVTGVVRGKGLKADRLVQIGDWGTFQVEKITAAPLTVRKRKGDDTAMEDVEQILDTPTEDRDGLEDLAPEEAVMRDDDEDEMMDAASTVTTSKKGVLLDDHRYYSEDEEEEEERKLPKRVPKGTSKYQAAWFLDDDDISDSGTDLEDLDMEDAQSEASEESARPEDGIEGLAGADDAMTEAGPSEYPQSVAFEEPDEEEDMRALEAYRKLKRTEAEDDREFPDEIELHPKVLARERLAKYRGLKSMRTSPWVEEEDRAFEPEEWQRLLRIPDYRASRIRAAREALVGGVAPGTRVNVYVKGLPGRARESYKPGQPLPLVSLLRHEHKRTAMNILINLPSDFPASIKSKSEMIVQYGARRFVINPLFSQPGSTPNDVHKYCRYLHPGQSAVATFMGPVTWGSVPALFFMRDPPTSNDPEAEEQTSASTLPLTLVATGTTLPPSTKRVIAKRAILTGHPYHIHKKIVTVRYMFFNREDVEWFKALPLWTKRGRSGYIKEPLGTHGYFKATFDGRINPQDTIGVSLYKRVWPRNARPLEGALLDEKEVAAKKGEDTEMVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZH1</accession>
    <name>G0RZH1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0002940</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690841.1">
        <property type="nucleotide sequence ID" value="XM_006690778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZH1"/>
    <dbReference type="GeneID" id="18254332"/>
    <dbReference type="KEGG" id="cthr:CTHT_0002940"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049940_0_0_1"/>
    <dbReference type="OMA" id="IYGDQSC"/>
    <dbReference type="OrthoDB" id="6910977at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="265"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="108"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="338"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="338"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS23599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="401" mass="44131" checksum="D4476D823232C653" modified="2011-10-19" version="1">MTTMELTPPPSIVRSPASPTHTYCPSERSSLDYPSPGLVDQQYKLSSIYGDQSCVVSPPMEPDSSLPPLDSMAQHEWNALHPTSSASVMPSILSPEYDSFGSYSYSHDAYHQSPNQPSVIHAPTPPPTSSAPRSPVAPPRTTMPAYTSATSIPPLTPRIKMEGGPEYNQTIEAAQYPSPRSAQTPSYPSENGPYAGSSTSGYLSDGTANTASWSKPEYQPLETDHLYPPPPVLQPTPFLQDVKRFRVQRPRRQQRRLTTKEEANFICEFKGCGKMFSRSYNYKAHLETHDEKREYPFPCQVPDCNKRHMEDGCSKRFDIGTLDIRPDGAASFESLRPLGPPPPHTPLGHMIPPPHTPGTLPPIGIPPPPLLSSVPPALRPRDPQTTLSHLTETHSGHSWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZH2</accession>
    <name>G0RZH2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative U4/U6 small nuclear ribonucleoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0002950</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690842.1">
        <property type="nucleotide sequence ID" value="XM_006690779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZH2"/>
    <dbReference type="STRING" id="759272.G0RZH2"/>
    <dbReference type="GeneID" id="18254333"/>
    <dbReference type="KEGG" id="cthr:CTHT_0002950"/>
    <dbReference type="eggNOG" id="KOG2769">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015750_2_2_1"/>
    <dbReference type="OMA" id="CVMHPRF"/>
    <dbReference type="OrthoDB" id="10264544at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24162">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013881">
        <property type="entry name" value="Pre-mRNA_splic_Prp3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027104">
        <property type="entry name" value="Prp3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010541">
        <property type="entry name" value="Prp3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212">
        <property type="entry name" value="U4/U6-ASSOCIATED RNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08572">
        <property type="entry name" value="PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06544">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor 3" evidence="7">
        <location>
            <begin position="100"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Small nuclear ribonucleoprotein Prp3 C-terminal" evidence="6">
        <location>
            <begin position="334"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="42"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS23600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="478" mass="53490" checksum="3078E0FDE198D06A" modified="2011-10-19" version="1">MDRSQQIGGLGPRHDATSRVQKPESAADRFAALKARVAAAISSSKAKGGLNTPLHPALADLNAPTKPGDPLKSAIGLRSTQDASKPGPKGKPTADGPKENPYLDTSGTPAGRERAPRQLIFNQKGKYIAQANALRRQAALEEMKKRIAEQARKAGLDEDRDVEKAFVVEAPPELEWWDEGLIDGKDYSNIPDSIKLRTPDSIITIYIQHPVAIEPPQDKLAPPPKPMYLTPKEQAKLRRQRRMMELKEKQAKIRLGLEPAPPPKVKKSNLMRVLGEEAVKDPTAVEARVNREIQERFEKHMAANEARKLTKEQRHEKLLQNQAKDAAKGIHMLVFKINSLANGQHRYKISINATQNGLSGVCIMNPKFNLVIVEGGEHSINNYKKLMMRRIDWTESLPPREKEGGNGIPVRDWLKAEDEKGNLKDLSHNKCVLVFEGEVKAQSFKKWGTKICETDQEAREFLAQKKLDTFWTQAKNIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZH6</accession>
    <name>G0RZH6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0002990</name>
        <name evidence="13" type="ORF">CTHT_0022650</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495</strain>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the histone H4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690846.1">
        <property type="nucleotide sequence ID" value="XM_006690783.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692731.1">
        <property type="nucleotide sequence ID" value="XM_006692668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZH6"/>
    <dbReference type="SMR" id="G0RZH6"/>
    <dbReference type="STRING" id="759272.G0RZH6"/>
    <dbReference type="GeneID" id="18254337"/>
    <dbReference type="GeneID" id="18256303"/>
    <dbReference type="KEGG" id="cthr:CTHT_0002990"/>
    <dbReference type="KEGG" id="cthr:CTHT_0022650"/>
    <dbReference type="eggNOG" id="KOG3467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109117_2_3_1"/>
    <dbReference type="OMA" id="QKEHING"/>
    <dbReference type="OrthoDB" id="4567608at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000007">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="12">
        <location>
            <begin position="36"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS20435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS23604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="103" mass="11386" checksum="2696CB0E75674EFF" modified="2011-10-19" version="1">MTGRGKGGKGLGKGGAKRHRKILRDNIQGITKPAIRRLARRGGVKRISAMIYEETRGVLKSFLESVIRDAVTYTEHAKRKTVTSLDVVYALKRQGRTLYGFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZM8</accession>
    <name>G0RZM8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Splicing factor U2AF subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">U2 snRNP auxiliary factor large subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0003520</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Necessary for the splicing of pre-mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the splicing factor SR family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690898.1">
        <property type="nucleotide sequence ID" value="XM_006690835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZM8"/>
    <dbReference type="STRING" id="759272.G0RZM8"/>
    <dbReference type="GeneID" id="18254390"/>
    <dbReference type="KEGG" id="cthr:CTHT_0003520"/>
    <dbReference type="eggNOG" id="KOG0120">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021795_2_0_1"/>
    <dbReference type="OMA" id="MTQWDIK"/>
    <dbReference type="OrthoDB" id="10266058at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12231">
        <property type="entry name" value="RRM2_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12232">
        <property type="entry name" value="RRM3_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000097">
        <property type="entry name" value="U2 snRNP auxiliary factor large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
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    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006529">
        <property type="entry name" value="U2AF_lg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01642">
        <property type="entry name" value="U2AF_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23139">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="256"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="377"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="485"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="102"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS23656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="584" mass="67193" checksum="2CE8CE2693994EEE" modified="2011-10-19" version="1">MDSRPKKFQPRDQQADSGRHGSSRDYPSSRRDRDDRRDRDRDRDRERERERERERERERERERERDRDRDTRDRDSGRRRSRSPDYRRSRRDDEDPYASSRSRRDREREDRYSGRDRRSDREWDRDRGRSRRDDDDRRDRRERDLFDDRRRRDRDYERERDRRRSLTPPHKKREPTPDLTDVVPILERKRRMTQWDIKPPGYDNVTAEQAKLSGMFPLPGAPRQHAMDPSKLQAFMSQGGGANSAALKPTNSRQAKRLVVRNLPPSATEESLVNFFNLQLNGLNVIETTDPCLQAHIAPDRSFAMLEFRNSSEATVALAFDGISMDADDAGANGAEAVHGGLQITRPKDYIVPAVVEDPNYDPDSDVPSSVVIDSPNKISVANIPPYLNEDQVMELLVSFGKLKSFVLVKDNGTQESRGIAFLEYVDPSVSNVAIQGLNDMPLGEQKLKVKKASIGITQVAGEMSVNAMSMLAGTTSTHAEASSRVLQLLNMVTPEELMDNDDYEEIREDVLEECKKFGNVLSLKIPRPIGGNRQSAGVGKIYVKFEQVESATKALRALAGRKFSDRTVVTTYFPEENYEVNCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZV0</accession>
    <name>G0RZV0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0004290</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="759272.G0RZV0"/>
    <dbReference type="GeneID" id="18254467"/>
    <dbReference type="KEGG" id="cthr:CTHT_0004290"/>
    <dbReference type="eggNOG" id="ENOG502S9BI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041809_0_0_1"/>
    <dbReference type="OMA" id="IAVWGRA"/>
    <dbReference type="OrthoDB" id="66095at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS23728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="330" mass="37484" checksum="1A2AAF8D625EA1BB" modified="2011-10-19" version="1">MAGSRLSFTSYLSSFLSSLPFFGSSNSENTSSTTMSEPYEPSIADVLIVKAMLTKGICKSLPRELVDLVLDYAEYWPHMTVHESFNNQCVARGRSNRENRLILRTPPIGLKAPNWSTNANDTVFRPAPKDQTYSPETFQPFRVSPDPMLLRPCRRIVFTIRSHDQGWGGQFEDQGTFHGSWTWFEVGLERFVKPECGEGPEEGEKPTLRPDHLGTVLPLVEPDGEENGKRKYKPKHPLLPTPAVTIQVNRVAEQEYAEHKVVWSWDDYLDDNDTEAKAKLEENGRGSETGNGEFVRNLQLGDVITVWAKARFPGWENWIDWAKVDIYFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0I4</accession>
    <name>G0S0I4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0010130</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2015" name="Mol. Cell" volume="58" first="854" last="862">
            <title>Coordinated ribosomal L4 protein assembly into the pre-ribosome is regulated by its eukaryote-specific extension.</title>
            <authorList>
                <person name="Stelter P."/>
                <person name="Huber F.M."/>
                <person name="Kunze R."/>
                <person name="Flemming D."/>
                <person name="Hoelz A."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="25936803"/>
            <dbReference type="DOI" id="10.1016/j.molcel.2015.03.029"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.95 ANGSTROMS) OF 1-338</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="14354" last="14354">
            <title>Molecular basis for protection of ribosomal protein L4 from cellular degradation.</title>
            <authorList>
                <person name="Huber F.M."/>
                <person name="Hoelz A."/>
            </authorList>
            <dbReference type="PubMed" id="28148929"/>
            <dbReference type="DOI" id="10.1038/ncomms14354"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 27-361</scope>
    </reference>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691536.1">
        <property type="nucleotide sequence ID" value="XM_006691473.1"/>
    </dbReference>
    <dbReference type="PDB" id="4YNV">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.95 A"/>
        <property type="chains" value="A/B=27-338"/>
    </dbReference>
    <dbReference type="PDB" id="4YNW">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.95 A"/>
        <property type="chains" value="A/B=1-338"/>
    </dbReference>
    <dbReference type="PDB" id="5TQB">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.40 A"/>
        <property type="chains" value="B=27-361"/>
    </dbReference>
    <dbReference type="PDBsum" id="4YNV"/>
    <dbReference type="PDBsum" id="4YNW"/>
    <dbReference type="PDBsum" id="5TQB"/>
    <dbReference type="AlphaFoldDB" id="G0S0I4"/>
    <dbReference type="SMR" id="G0S0I4"/>
    <dbReference type="STRING" id="759272.G0S0I4"/>
    <dbReference type="GeneID" id="18255051"/>
    <dbReference type="KEGG" id="cthr:CTHT_0010130"/>
    <dbReference type="eggNOG" id="ENOG502QSAH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040959_2_1_1"/>
    <dbReference type="OMA" id="ETYMTDL"/>
    <dbReference type="OrthoDB" id="1914839at2759"/>
    <dbReference type="EvolutionaryTrace" id="G0S0I4"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd24142">
        <property type="entry name" value="ACL4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5 6 7" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="68"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="356"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="4YNV"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="4YNW"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="5TQB"/>
        </source>
    </evidence>
    <sequence length="398" mass="44747" checksum="511F8185E409E643" modified="2011-10-19" version="1">MAPTKPKNKSKKSKDRARLKVASSQTSINPKELLDRATTLLEEGDIETAAKVARTAYEHIGENGRHAGAALTLLGQIHVELGDIDAARNYYAAAVKVDEDGSLPEELGGGPEKFLWLAQLSEEGGHDSVAWFERGATVLRAQIQSLMDSLEQRPLSRGQVEAAIADKRRRLAETLCAVVEVYMTDLSWEDDAEQRCEALITEATMIAPEWPETWQTVANVRISQERTEEAREALRRSLGLWTHLPPEDPGVPPFPSRVSLVRLLIEVDMEEEALEVTERLIAEDDLSVEVWYLGGYARYRLGEKEREASGQASEPEAWKDTWRSSRKWLRQCLKVFEAEEYEDERLGEHAKELIASIIGELGEEGEDDDDEDDWEDVDDEGEDEEEADADHEDTEMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0Q6</accession>
    <name>G0S0Q6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0010880</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691608.1">
        <property type="nucleotide sequence ID" value="XM_006691545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0Q6"/>
    <dbReference type="STRING" id="759272.G0S0Q6"/>
    <dbReference type="GeneID" id="18255126"/>
    <dbReference type="KEGG" id="cthr:CTHT_0010880"/>
    <dbReference type="eggNOG" id="KOG0062">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1242">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002848_0_1_1"/>
    <dbReference type="OMA" id="EDHRKFG"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd18626">
        <property type="entry name" value="CD_eEF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000076">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.990:FF:000002">
        <property type="entry name" value="mRNA export factor elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000193">
        <property type="entry name" value="Probable Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015688">
        <property type="entry name" value="eEF3_ABC2_chromodomain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047038">
        <property type="entry name" value="eEF3_chromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF14">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="8">
        <location>
            <begin position="209"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="467"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="712"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1065"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1069"/>
            <end position="1078"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS22616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1114" mass="122833" checksum="2875F63F6DDFDC1B" modified="2011-10-19" version="1">MVVPITVADGVAPPPAPEDVAAILNVVFTAKTSNQSIDACYALCELLLSSVGFRGLYTYRILDEIKKAAADKKSGFRREGAQNLLGALFERFPPRQPVSEVIFLLKDGGLLGCALDALADKGAVVRDAAQYGIDALVTNLSIEAQLAGLLPALIEYIKKSGGKWQGVVGALKLMQKMADKAKAVIGSTKEQAQEQDFLREAMGAKLAGLIPIVENAMLDMKSEVEKQAVRTMTSLTTLLSNDDVAPRIPLLIDTMHHPSPQALQKAIHALSQTTFVAVVTSPVLALLTPFLERSLNNPTTPQEVLRQTVVITENLTKLVHDPIEARTFLPKLQPGIKSVVDRASLPEVRELATRALEVMDKAMAGDKAALVERTAAEDVAKVLDTEIKNRGGVVDTDTFHMVRPYICEMVSEDVNHRQLDRIQARIIPYLQGLNAAADAVAAAVHKFYVEEDHRKYGEPEKEDDGEIEIVNADFSLAYGGMLLLSHTNLRLLKGHRYGLCGRNGAGKSTLMKSIAAGKLEGFPPQDVLRTCYVEHNQGEDADISILEYVSKDPLIAEEDKARISDVLEEFGFTSGPEGRQSQKVGSLSGGWKMKLALARAMLQRADVLLLDEPTNHLDVSNIKWLENYLKTHTEITSLIVSHDSSFLDNVTTDIYHYEPNKKLSHYKGNLAAFVKQRPEAKSYYTLTASNVQLKFPPPGILTGVKSQTRAIIRMTNVSYTYPGAPKPSLSDVSCQLSLSSRVAIIGPNGAGKSTLIKLLTGELIPTSGKVEKHPNLRIGYIKQHALEHVEMHLEKTPNQYLQWRYAHGDDREVHLKQTRILSEQDRAQMEKWIDLPDGKGKRQVEALVGRQKYKKTFQYEVKWRGWLPKHNTMVSRETLLEWGFTKLVQEFDDHEASREGLGYRELQPSAIAKHFEDLGLDPEIANHNEIGSLSGGQKVKVVIAGTMWNNPHLLVLDEPTNFLDRDSLGGLAVAIRDFKGGVVMISHNEEFVGALATEQWHVRDGKVTNRISTNVALDRFEDVASSGTATPAQPGTSVANSAVNSDVENNAGSGAATPAGITEESMAFKAKKKKKKLTKRELKEREVRRRLRHIEWLSSPKGTPRPPDTDDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0S8</accession>
    <name>G0S0S8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH-ubiquinone oxidoreductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0011100</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="6 7 8" key="2">
        <citation type="journal article" date="2022" name="Sci. Adv." volume="8" first="eadc9952" last="eadc9952">
            <title>Conformational changes in mitochondrial complex I of the thermophilic eukaryote &lt;i&gt;Chaetomium thermophilum&lt;/i&gt;.</title>
            <authorList>
                <person name="Laube E."/>
                <person name="Meier-Credo J."/>
                <person name="Langer J.D."/>
                <person name="Kuhlbrandt W."/>
            </authorList>
            <dbReference type="PubMed" id="36427319"/>
            <dbReference type="DOI" id="10.1126/sciadv.adc9952"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.44 ANGSTROMS)</scope>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691630.1">
        <property type="nucleotide sequence ID" value="XM_006691567.1"/>
    </dbReference>
    <dbReference type="PDB" id="7ZM7">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.77 A"/>
        <property type="chains" value="X=1-191"/>
    </dbReference>
    <dbReference type="PDB" id="7ZM8">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.76 A"/>
        <property type="chains" value="X=1-191"/>
    </dbReference>
    <dbReference type="PDB" id="7ZMB">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.75 A"/>
        <property type="chains" value="X=1-191"/>
    </dbReference>
    <dbReference type="PDB" id="7ZME">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.83 A"/>
        <property type="chains" value="X=1-191"/>
    </dbReference>
    <dbReference type="PDB" id="7ZMG">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.44 A"/>
        <property type="chains" value="X=1-191"/>
    </dbReference>
    <dbReference type="PDB" id="7ZMH">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.47 A"/>
        <property type="chains" value="X=1-191"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0S8"/>
    <dbReference type="EMDB" id="EMD-14791"/>
    <dbReference type="EMDB" id="EMD-14792"/>
    <dbReference type="EMDB" id="EMD-14794"/>
    <dbReference type="EMDB" id="EMD-14796"/>
    <dbReference type="EMDB" id="EMD-14797"/>
    <dbReference type="EMDB" id="EMD-14798"/>
    <dbReference type="SMR" id="G0S0S8"/>
    <dbReference type="STRING" id="759272.G0S0S8"/>
    <dbReference type="GeneID" id="18255148"/>
    <dbReference type="KEGG" id="cthr:CTHT_0011100"/>
    <dbReference type="eggNOG" id="ENOG502S1BF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087364_0_0_1"/>
    <dbReference type="OMA" id="TVPWFNF"/>
    <dbReference type="OrthoDB" id="196140at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053229">
        <property type="entry name" value="NADH-Q_oxidrdct_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024549">
        <property type="entry name" value="NADH-UbQ_OxRdtase_su21_C_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019721">
        <property type="entry name" value="NADH-UbQ_OxRdtase_su21_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34062:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 21KDA SUBUNIT N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34062">
        <property type="entry name" value="OXIDOREDUCTASE 21 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10785">
        <property type="entry name" value="NADH-u_ox-rdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12853">
        <property type="entry name" value="NADH_u_ox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6 7 8" id="KW-0002">3D-structure</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 21kDa subunit N-terminal" evidence="2">
        <location>
            <begin position="18"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 21kDa subunit C-terminal fungi" evidence="3">
        <location>
            <begin position="112"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS22638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="7ZM7"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="7ZM8"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="7ZMB"/>
        </source>
    </evidence>
    <sequence length="191" mass="21620" checksum="0469A7D2E10D9634" modified="2011-10-19" version="1">MSNTPTQTYQFPSKTVKTDYPLIDNDPHFTRVIRYARPSDYAHGLAAAAAGPAALWLMERISPSQVGRGGFAKAMRLAGFIGLAGGFLYFYQRSILRFYGMSENAREVEMDMREMTDRVKAGLPLYGESRLSPAMQGVAARQSRYSALFFGVMPWFNFVNHNQHGVDTAKYYQQAERELEAERLAREQAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0V4</accession>
    <name>G0S0V4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0011370</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006691593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0V4"/>
    <dbReference type="GeneID" id="18255175"/>
    <dbReference type="KEGG" id="cthr:CTHT_0011370"/>
    <dbReference type="HOGENOM" id="CLU_041827_0_0_1"/>
    <dbReference type="OMA" id="FPMHEDP"/>
    <dbReference type="OrthoDB" id="5403157at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="326" mass="34957" checksum="47EF0786504E633A" modified="2011-10-19" version="1">MEIRNPSFGNLNTARAGTRQRTLSDPSEASRRSELSDELFALSPINTPRNEQPQFSAATGPRYSGPASITRKATSPFTHAEAKPIPIVLPRRRVDLTSKAAVTPDPPLSARGDIPGAYFPLHEDPRSRVKIPHPFREGATTPHGESASHAPVERNTAPDLEEGESPMTVTPTGSPQFPFPSSIGAFPPPTPSPTTLPASGDLLERRYGWPAAPSLITSHPAGSDRPQTMRQSRSDARHRLLQYQRDMVTQMSMAAQVALTRADTTKTRIETGRADGETSDVGNALIVARARLTAASVVRPDSPQLRPLSSPGPVTPISLAPSPADT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0S198</accession>
    <name>G0S198_CHATD</name>
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        <submittedName>
            <fullName evidence="4">Vacuolar ATP synthase subunit e-like protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">CTHT_0012830</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase E subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691800.1">
        <property type="nucleotide sequence ID" value="XM_006691737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S198"/>
    <dbReference type="STRING" id="759272.G0S198"/>
    <dbReference type="GeneID" id="18255321"/>
    <dbReference type="KEGG" id="cthr:CTHT_0012830"/>
    <dbReference type="eggNOG" id="KOG1664">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073641_0_0_1"/>
    <dbReference type="OMA" id="QHMMAFI"/>
    <dbReference type="OrthoDB" id="10263003at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033178">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, catalytic domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.30">
        <property type="entry name" value="ATP synthase, E subunit, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00311">
        <property type="entry name" value="ATP_synth_E_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038495">
        <property type="entry name" value="ATPase_E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002842">
        <property type="entry name" value="ATPase_V1_Esu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45715">
        <property type="entry name" value="ATPASE H+-TRANSPORTING V1 SUBUNIT E1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01991">
        <property type="entry name" value="vATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160527">
        <property type="entry name" value="V-type ATPase subunit E-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS22808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="230" mass="26033" checksum="36C4A7C04473B816" modified="2011-10-19" version="1">MSQVHALSDDQVGQELRKMTAFIKQEASEKAREIEIKADEEFAIEKSKLVRQETDAIDQAYQKKFKQATMSQQITRSTLANKTRLRVLAARQELLDEIFNAAEQRLGEPTKDAVRYEGILKGLILEGFYAMDEPALQIRSRKQDREVVRKAIDAAVKEYKDKTGKEISATVDERNDLPEGSAGGVFIVGGNGKIDIDNTFETRLKHLKESALPAIRETLFGKNPNRKFFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1A5</accession>
    <name>G0S1A5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0012910</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691807.1">
        <property type="nucleotide sequence ID" value="XM_006691744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1A5"/>
    <dbReference type="STRING" id="759272.G0S1A5"/>
    <dbReference type="GeneID" id="18255329"/>
    <dbReference type="KEGG" id="cthr:CTHT_0012910"/>
    <dbReference type="eggNOG" id="ENOG502SBUF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030814_0_0_1"/>
    <dbReference type="OMA" id="AMPPIIN"/>
    <dbReference type="OrthoDB" id="1109245at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11660">
        <property type="entry name" value="SANT_TRF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052450">
        <property type="entry name" value="TRBD-Containing_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46734:SF1">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46734">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 1 TERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="4">
        <location>
            <begin position="227"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="3">
        <location>
            <begin position="227"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="191"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="262"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="547"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="272"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="340"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="548"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="565"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS22815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="638" mass="69229" checksum="6039621EB9BEA6DB" modified="2011-10-19" version="1">MATIEPRLIHLLNGPEPEALPPIQQSSSSTAAPGPPISLPPLEPELKSSCKVDIAIPTRLTPRRAASDDHLTRPPPRSDDNSSALLTASVVPLQLLLSESEPAVPGIPLSKIVDDVPPETQEDGSKKRHLTPNAKDDFVQLPKLPKKRKSTQQLPPIVPPLVQPPPDPAVFPPIASAPLGESETFNFGSLKDFGSNTVASGPEDRSAPAAVSQEEPKPTTTTKPKRRAMKPRKKWTEEETNNLLLGVSRYGVGRWTSILEDPDFEFNGRTAGDLKDRFRTCCPDELRVTTDDERPTNGSKGLKDDAKPKNKADLGNILIQGEEGDATEPSGPPDSDEQPKRRKSRTHRKKLEDLAQLGIHGPFEKSHRRKRRPFTQQDDDEILDGLRQYGASWSRIQRDPNYHLSSRQPTDLRDRVRNKYPEIYAQIEKANMLAKEAARAAGGSGKCTVSASVLEPLINNAARMSLDRKSYHHHHLNRSRSKEEMPVSQRQPMTEKTLSAYGSTESLPALNELFDLSGNSAVPGSELSIAASAGRATSSAAFLRATTGRPTGTTSEMDVTPVGTAVSSGGHSSAPVQPVPSSIATSAVASREESSSTVLPELPRLPSIQPPQEDSRHTGFGVTGVFPSRLRNPGWAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1F8</accession>
    <name>G0S1F8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Superoxide dismutase [Cu-Zn]</fullName>
            <ecNumber evidence="4 12">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0013440</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2021" name="Protein Pept. Lett." volume="28" first="1043" last="1053">
            <title>Crystal Structure of a Cu,Zn Superoxide Dismutase From the Thermophilic Fungus Chaetomium thermophilum.</title>
            <authorList>
                <person name="Mohsin I."/>
                <person name="Zhang L.Q."/>
                <person name="Li D.C."/>
                <person name="Papageorgiou A.C."/>
            </authorList>
            <dbReference type="PubMed" id="33726638"/>
            <dbReference type="DOI" id="10.2174/0929866528666210316104919"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.56 ANGSTROMS) IN COMPLEX WITH CU(2+) AND ZN(2+)</scope>
        <scope>DISULFIDE BONDS</scope>
    </reference>
    <comment type="function">
        <text evidence="1 12">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="12">Binds 1 copper ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="4 12"/>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691860.1">
        <property type="nucleotide sequence ID" value="XM_006691797.1"/>
    </dbReference>
    <dbReference type="PDB" id="6ZS1">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.56 A"/>
        <property type="chains" value="A/B/C/D/E/F/G/H=1-154"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1F8"/>
    <dbReference type="SMR" id="G0S1F8"/>
    <dbReference type="STRING" id="759272.G0S1F8"/>
    <dbReference type="GeneID" id="18255382"/>
    <dbReference type="KEGG" id="cthr:CTHT_0013440"/>
    <dbReference type="eggNOG" id="KOG0441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056632_4_1_1"/>
    <dbReference type="OMA" id="AQRGFHI"/>
    <dbReference type="OrthoDB" id="2015551at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000001">
        <property type="entry name" value="Superoxide dismutase [Cu-Zn]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018152">
        <property type="entry name" value="SOD_Cu/Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00087">
        <property type="entry name" value="SOD_CU_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00332">
        <property type="entry name" value="SOD_CU_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="17" id="KW-0002">3D-structure</keyword>
    <keyword evidence="8" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="10 12" id="KW-0186">Copper</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 12 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 17" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="14">
        <location>
            <begin position="14"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="58"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS22868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PDB" id="6ZS1"/>
        </source>
    </evidence>
    <sequence length="154" mass="15956" checksum="E5FAC14F2118A590" modified="2011-10-19" version="1">MVKAVAVVRGDSKVTGTVTFEQESESSPTIITWDITGHDPNAKRGMHIHTFGDNTNGCTSAGPHFNPHGKTHGAPTDENRHVGDLGNIETDANGNSKGTMTDHLVKLIGPESVIGRTVVVHAGTDDLGKGGNEESLKTGNAGPRPACGVIGIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1M9</accession>
    <name>G0S1M9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0014180</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006691868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1M9"/>
    <dbReference type="GeneID" id="18255456"/>
    <dbReference type="KEGG" id="cthr:CTHT_0014180"/>
    <dbReference type="eggNOG" id="ENOG502T3XP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_483107_0_0_1"/>
    <dbReference type="OMA" id="NCFWNNT"/>
    <dbReference type="OrthoDB" id="4775454at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="564" mass="61264" checksum="73E79CA2A36C19B6" modified="2011-10-19" version="1">MNRLGIANSEEVPRLSQPQGRSHPPPKLYVANFSYPRSNAAHFYPRVQPMLSPTRDSTAFDTSIPPMVEDHGSDFSADEESHDCASGDLLDSFWQLKEQLDRKQEYSPQSAVAGHNWAQDEPGIFEADSPVLPVTAVGPPKQQEQLLQRTMPRPEQRPQLLKAAPKVTYSLFPPTKPEPQIKRQPLSPVPQRQPASLPQAEALEPSPILSGTSAVPFSGKVAFAPRGDNNLPPAIAPISGSEASSRVTSPISPQDYPPASSSSDSFSLILQTNTSPHQSPSASPIDATSPNRLARYSSLKNLRTLGLSKAKTRSSPSLAQLAKSHSDRPPQTQEPARLPQDATPLHSEDRKPPPIPLVPHRPPPTPPPVSVFETDSDDGSDETSRHANKSFCRRLVHGLVHPYRHHNSPNRSHIRHISSPLLFSHIRRGKVSGQPPHKRSVSDEGPSGFSKAFKPQTGHFVGGKSETNSSSGGSGVLARTIFSSMRARNNSSGGVVSAGTGAGSSVDSDVGSGEQQTPLGRRAMSMDLPRRMGSDDNLLPAELREMEKERMKDKFLGRFLKRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1Y0</accession>
    <name>G0S1Y0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Putative calcium ion binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0015240</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the PAN1 actin cytoskeleton-regulatory complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS23040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006691969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1Y0"/>
    <dbReference type="STRING" id="759272.G0S1Y0"/>
    <dbReference type="GeneID" id="18255562"/>
    <dbReference type="KEGG" id="cthr:CTHT_0015240"/>
    <dbReference type="eggNOG" id="KOG0998">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002006_0_0_1"/>
    <dbReference type="OMA" id="AMYLVRQ"/>
    <dbReference type="OrthoDB" id="524326at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd14270">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="3"/>
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        <property type="match status" value="4"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="19"/>
            <end position="95"/>
        </location>
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            <begin position="1213"/>
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    <evidence type="ECO:0000256" key="3">
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        <source>
            <dbReference type="ARBA" id="ARBA00025194"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50222"/>
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    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS23040.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1274" mass="134835" checksum="80763276A2CCBF92" modified="2011-10-19" version="1">MAEATIEPGAPNLNLTPEEKRVYGQLFRQADSDNVGVVTGEVAVKFFERTKLDSRILGEIWQIADKENRGFLTPAGFGIALRLIGHAQNGREPLPELAFQPGPLPRFEGFTPTPPPPAPGALQAQPTGAPGPIRIPPLTPEKVAQYAALFERQNLQGNMLSGEEAKKIFEKSGLPNDILGRIWMLVDSEQRGALVQTEFIIAMHLLTSMKTGALRGLPNILPAALYEAATRRPSIGASIPRQQSPTTATPPIPAIPRQLSGQAPLQQMRTGSPLGRPPTMSAQSTGGDWLITPADKARFDQLFDELDKGRKGFISGEEAVPFFSQSNLSEDVLAQIWDLADMTSAGRLTRDEFAVAMYLIRQQRSKAGVPLPTTLPPNLIPPSMRAQVRPATATSAFDVPPKPQPKPPSAMDDLMSILDDPQPAAPAPTQVPTTTGGSTATDPFATSVSPPVPSSPTRTSPATSSTTFKPFVPTSSFGRSLTAQATGGSNASSAAKPAATEDDLLGDADPEVNKQTTNETMELANLSNQIGSLTKQVQDVQAQRTAIQNELSQASIQKKNFEQRLAQLRSLYEKEAADVRTLESQLTTVKNENKKLQAECAMIDASYQELQNQHRQLLTALQADQQENANLKEKIKLVNAEIAQLKPQIEKLKSEARQQKGLVAINKKQLATSEGERDKLKNEVDELTRTNEELSRQISASSSPAPAQVSSPALSTASVNNPFFRRTGSTDITSPSAPQLRPFTDKSFDDIFGSSSVPNPVPAQNTGTSTGSNGFATPSSGSPNVSRQPTGAEVPATSAEAPKSTSAFSSLPADNAESLSTSRQAPPLSRTDTSPDGPSLAPPAQIEPAQSEPARPSTAATSATENKPATFSSPSSPDNKETDPFALAEQERKAKEDFESAFASFKKARAANNPAVSFAQFNAEFPPISELERDESDSESERGGFDDDFAPPSPPKAPQQSSTGSRSASPTLTKSTPDATASAGAEQAGASDKPSSSAVSSTNLNNLNSSHVNDIFGSAATTSAPATTQVTSSNTSRPATANTSSKANAFDDLDDDFEGLEDAKEGSADDDFANISRSGFDDFNPVFDSSPPPSQPKPDSSHSAFDSFDFGSLSSASGAAPGSSQQSQPKEQHDWDAIFAGLENAASASQNLASTVTTGADAGSSAPKESAAATTGGDNSKTDAGAPAGPSSLSARPDTPVRRAFSDDGDNGENDHPDVKKLTNMGWSRKDSIAALERNDYNMERVSQTYYGISKGSTSSSRSRESGSNRRVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2X9</accession>
    <name>G0S2X9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetyltransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0018880</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_006692318.1"/>
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    <dbReference type="STRING" id="759272.G0S2X9"/>
    <dbReference type="GeneID" id="18255926"/>
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    <dbReference type="eggNOG" id="ENOG502QRFX">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_42_5_1"/>
    <dbReference type="OMA" id="PPTHHTS"/>
    <dbReference type="OrthoDB" id="10264707at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
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    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052742">
        <property type="entry name" value="Mito_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015416">
        <property type="entry name" value="Znf_H2C2_histone_UAS-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138:SF2">
        <property type="entry name" value="PROTEIN SPT10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="zf-H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="79"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="345"/>
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            <begin position="348"/>
            <end position="361"/>
        </location>
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            <begin position="615"/>
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    </feature>
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        <location>
            <begin position="719"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="771" mass="82438" checksum="8294EEA01A0E5EE0" modified="2011-10-19" version="1">MPAILEDPDAPTIYRVSGDPPYPDPANPSLPPSIQPRHVTLRDRQTVATVVPFASRHQVPESLLRYLNDQFNKEIEKGDTYPMMEPMSFDKFASYWFQNFAGIMLLGHIESPADVVEGKDWSKECLGTFYIKPNYPGRSSHICNAGFIVTDASRNRGVGRLMGEAYLDWAPKLGYKYSVFNLVYETNVASCKIWDALGFKRIGRVKGAGNLKSYPDRLVDAIIYGRDLGDAAGGSGNEELVSEERFDKIRFYLKTGRYPNGADRAEKSRLRSAATHYKLVDDVLMLHDKEVISDPQRQYEIARQVHNQAHAGINKTTATIAERYHWSRIKETVSDVIRNCAECKESSSKSSNHNNAGAASAVQSHQGTPAVTGCSSSGVSGQGGVSNLNPLKRPVNVAVSSDALQPPSKRASPSPAASAASVTTTTAGVSAVASVPVTAPSAGPAPEIISPAVAAAAAVAAATLGQHRHAPPPVPPPLTDGPGLPDPSHLAPFSVAAHHHHHQYADPAAISILTPGATAAAHHGLASGDTGSPVTGHDHDPSQVQLHAQYKAFHSSHPHHHTSASLSGLSAVSPDYSAPIDPQIISQSASNPADHLHHAAAAAAAYANPFDTTPRHHHHHHHHHHHQQQHGQPTHHPFHQHPSGLAQAHHDPDTDTFQALLNATGEDEAPSTSGSNPVNPANNLPQHPTRSQSVLVSVTHSQAPGTSTTTSTHTRTPVDEDADADADADADAEADPDPAPDPEDADTMDRDLEMLLEQAQQEGMELGNIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0S309</accession>
    <name>G0S309_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Regulatory P domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0019230</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692411.1">
        <property type="nucleotide sequence ID" value="XM_006692348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S309"/>
    <dbReference type="GeneID" id="18255961"/>
    <dbReference type="KEGG" id="cthr:CTHT_0019230"/>
    <dbReference type="eggNOG" id="ENOG502QQSB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031217_0_0_1"/>
    <dbReference type="OMA" id="EGNDIWG"/>
    <dbReference type="OrthoDB" id="2099887at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027589">
        <property type="entry name" value="Choice_anch_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013211">
        <property type="entry name" value="LVIVD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04312">
        <property type="entry name" value="choice_anch_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38787">
        <property type="entry name" value="REGULATORY P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38787:SF3">
        <property type="entry name" value="REGULATORY P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08309">
        <property type="entry name" value="LVIVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS22392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="487" mass="53976" checksum="4B0B5D8484467C2D" modified="2011-10-19" version="1">MKPTPFILAATAAHAQIKTASIMEELMALKEAEWDTFAQQGLFGGSALYPKISNRIPCINGKAVLSTKGNNTYSCRNVDLHAFLSHEDLGSQAKAGNDVWGWTSPAGREFGIVGQRDGVAFVEVDTKTGALTYLGRLDTHTDATNWRDIKVIGHHAYIGAESHDHGLQIFDLRKLEAIRPQAKSFWWDFLGLFTPKPQFTPKVFNKTTDITAHFAGFGASHNIVAHPERNMIYAVGGRSGANARDTPCKGGMFMVDVSDPTNPTSPGCVPQDGYVHDAQCVVYRGPDVRYQGREICFNFNEDSLTIMDLTDKSNPVVVSRTGYNGVAYSHQGWLVDEGMEWLLLDDELDERSGTVPFGDGRTTTYIWNVTNLENPINTGFYKSPARSIDHNQYVHKGLTYQANYASGLRIVDVSGVEIDPTGGNFEEVGFFDCYPEDDETEGSLAFIGTWSVYPYFKSGYILLNSIERGIFSLKYTGRKARWYSGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3S6</accession>
    <name>G0S3S6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="2">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0030480</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="2"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693498.1">
        <property type="nucleotide sequence ID" value="XM_006693435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3S6"/>
    <dbReference type="STRING" id="759272.G0S3S6"/>
    <dbReference type="GeneID" id="18257086"/>
    <dbReference type="KEGG" id="cthr:CTHT_0030480"/>
    <dbReference type="eggNOG" id="KOG1200">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_1"/>
    <dbReference type="OMA" id="HGNAGQI"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050259">
        <property type="entry name" value="SDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879:SF2">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="7">
        <location>
            <begin position="22"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS21202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="291" mass="30467" checksum="D7C090CBAD2A0612" modified="2011-10-19" version="1">MAERIGQIARQLNYPKGLLYGQVAIITGSGQGIGAECARLFANEGAKVVVTDIDAKKTQEVVDTIRASGGKAIAVAGDMLDDNHIKELVKKAAEFGNGKIHIIVNNAGFTWDGVIHKMTDKQWDTILALHATVPFKLVREAAPYFRVKDGEPRNIINISSTSGLHGNAGQANYALAKAGVVGLTKTIAKEWGPQFGVRANTIAFGHIATRLTADKEAGAFIEVAGEKVALGIPSKQKKAQQANAGGVKYADIPLGRPGTATEAASAVLAIASPLSSYISGQTISVTGGRNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G0S403</accession>
    <name>G0S403_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0022060</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692675.1">
        <property type="nucleotide sequence ID" value="XM_006692612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S403"/>
    <dbReference type="GeneID" id="18256244"/>
    <dbReference type="KEGG" id="cthr:CTHT_0022060"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_2_0_1"/>
    <dbReference type="OMA" id="CIMNIAL"/>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000247">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF29">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS20379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="280" mass="32506" checksum="5555E10DFAF1D128" modified="2011-10-19" version="1">MPASATQTKTWFRPKGMFTDREVGIIVNRVLRDDPSKGDMNNREGITLQRLWEVFKEYDLWPMYILGIVGFIPQGPVSAYWTLTLRSLGFNPFVTNLLTIPSTIFHILNLIFITHLSERLDERTLVSMLMPLWTLPCMIALRFWPRLIDDAWGTYALITVLLSYPYCHAILAAWTSKNANNVGTRTVASALYNISVQLGHVCYSFAYQDYDKPYYRHGNTKLLAVNILSIALFLATKAYYIWRNKQKDKIWDSMTEDEKSEYIRCSTDKGCKRLDFRFAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4L4</accession>
    <name>G0S4L4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Survival factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0031420</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SVF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693585.1">
        <property type="nucleotide sequence ID" value="XM_006693522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4L4"/>
    <dbReference type="STRING" id="759272.G0S4L4"/>
    <dbReference type="GeneID" id="18257180"/>
    <dbReference type="KEGG" id="cthr:CTHT_0031420"/>
    <dbReference type="eggNOG" id="ENOG502QQY3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030205_2_0_1"/>
    <dbReference type="OMA" id="AFWPRCV"/>
    <dbReference type="OrthoDB" id="2590239at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051385">
        <property type="entry name" value="Ceramide-binding_SVF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033394">
        <property type="entry name" value="Svf1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013931">
        <property type="entry name" value="Svf1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47107:SF1">
        <property type="entry name" value="CERAMIDE-BINDING PROTEIN SVF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47107">
        <property type="entry name" value="SVF1-LIKE PROTEIN YDR222W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08622">
        <property type="entry name" value="Svf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17187">
        <property type="entry name" value="Svf1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159245">
        <property type="entry name" value="AttH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Svf1-like N-terminal" evidence="4">
        <location>
            <begin position="55"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Svf1-like C-terminal" evidence="5">
        <location>
            <begin position="216"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS21289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="381" mass="41912" checksum="4E912DB68D0071C6" modified="2011-10-19" version="1">MFRWAQQALANVAGTQEPIYGPSAIKSVAEETVTTPYTELTRDDLRWEALESTCVETQTFYFMSEGGQLAFCQVIYSSLAGIRTTCQFNCKIFSLDGSKPHLWCSTPLINHEFSEDKTAFYANDLAVELSEDGTTFTIKSMNDPNAIVNLVVRRTAPGFKAGKTGKTLFGTDLSNPWGSMRHLFWPRCESEGTITTKDGPIDFKGRAFFAHALQGMKPHHAAAKWNFCNFQGPTYSAILMQFTTPPSYGSTVVAVGGIAKDGEIIVAGCESDVAHLETKSDSQNDWPEPTIIKYTWAGKTKDNKPVTAVIEGALEERLDRIDVMAEVPGFVKSIVAAAAGTKPYIYQYSPQKQKLSLKLKIGDQEVTEEGVIFTEATFISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4S1</accession>
    <name>G0S4S1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dtdp-glucose 4,6-dehydratase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0023320</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692796.1">
        <property type="nucleotide sequence ID" value="XM_006692733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4S1"/>
    <dbReference type="STRING" id="759272.G0S4S1"/>
    <dbReference type="GeneID" id="18256370"/>
    <dbReference type="KEGG" id="cthr:CTHT_0023320"/>
    <dbReference type="eggNOG" id="KOG0747">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_14_1"/>
    <dbReference type="OMA" id="KLIPLMC"/>
    <dbReference type="OrthoDB" id="331544at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05246">
        <property type="entry name" value="dTDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000304">
        <property type="entry name" value="UDP-glucose 4,6-dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005888">
        <property type="entry name" value="dTDP_Gluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43000">
        <property type="entry name" value="DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="4">
        <location>
            <begin position="57"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS20500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="472" mass="53266" checksum="B7BBAAB03D02BEA3" modified="2011-10-19" version="1">MTISDGAAQGNGVANSHVKNDTSGRPSFFEDYGVWKEAPVLVGTTKFEPLPDVKNIMITGGAGFIACWLVRHLTLTYPHAYNIVSFDKLDYCSSLNNTRVLNDRRNFTFYQGDITNPSEVLDCLERYNIDTIIHFAAQSHVDLSFGNSYHFTHTNVYGTHVLLESAKRVGRIKRFIHVSTDEVYGEVRDDDDDLLETSILAPTNPYAASKAAAEMLVHSYQKSFKLPAIIVRSNNVYGPHQYPEKIIPKFICLLNRGKPVVLHGDGSPTRRYLYAGDAADAFDTILHRGQIGQIYNVGSSDEISNLSLAKKLLSLFSISHDRREEFSRWVKYTHDRPFNDHRYAVDATKLRQLGWKQQMSFEEGLRITVEWYRRFGERWWGDISKVLSPFPVVSGREVVEDDEHVSDNPQGADSVCVRGLRIKRTSGSCGGDEAESVKKKRKVDEFDGRQQQKQMASFTATACTSSIPEKCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4U0</accession>
    <name>G0S4U0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0023510</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692815.1">
        <property type="nucleotide sequence ID" value="XM_006692752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4U0"/>
    <dbReference type="STRING" id="759272.G0S4U0"/>
    <dbReference type="ESTHER" id="chatd-g0s4u0">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="18256389"/>
    <dbReference type="KEGG" id="cthr:CTHT_0023510"/>
    <dbReference type="eggNOG" id="KOG4389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_8_1_1"/>
    <dbReference type="OMA" id="IEFRCLD"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF3">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G09070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005130791" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="17"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="168"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS20519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="669" mass="74002" checksum="7F257F901F2927E8" modified="2011-10-19" version="1">MRLAGLALALASLAAGEHLKRLDTSLTIITNNDLQGSNSPYADSAVILTDPVSRDASRGVCSRLNEKLWQPVKSKRVKRASSSLYFADYLKYTGAATSSSKFWISNSDAVDTIGRVTKGPSSAQYQALCTNTAPYSNQSFQDTNEKWHISLDVNNQTLTGFRDRLSFRFLGIRYAPQPQRFGYPTLFKGSGESVSALEYGSQCFQWGSGSEDCLFLNIWTPYLPNPNKKTNKKTLRPVAFWIHGGAFIGGTANDATFDGANMASRGDMVVVAINYRVSALGFLALNDGVTNGNYGLADQITALEWVRQHIHHFGGDPDRITIFGQSAGAASVRALIASPKSVGKFSNAIMLSNLGGIHYGTTYSRYYTIEEQVAVAANQLLEATGCSNAASQVECLRQVPASTLSTFTDVRFLVVDGTYLTSRELPLDKGKRYPVNLMMGITRDDGAPFVSYPQTTNRTEYLASVDLPNVPLKLFPQPNTGNGTRDVFWGTSRIATDGIFRCADQATAFAGLSNNRFDKVYYYEFDRTYQPGGWPELDLCNAPRSAKFPHGDPSKDYLRCHSGELYYVFGNLHRQGLPMRDDGDLPFEQFVTDSFVSFIRTGDPNPDEAYLRAKGYTETLKQLKISGTWKPSVKGRYSLRVFDYPKSRMEPFRDIQQCEALGLGLGYYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4Z8</accession>
    <name>G0S4Z8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gal4-like Zn(II)2Cys6 binuclear cluster DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0023550</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692819.1">
        <property type="nucleotide sequence ID" value="XM_006692756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4Z8"/>
    <dbReference type="STRING" id="759272.G0S4Z8"/>
    <dbReference type="GeneID" id="18256393"/>
    <dbReference type="KEGG" id="cthr:CTHT_0023550"/>
    <dbReference type="eggNOG" id="ENOG502SFBR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011833_0_0_1"/>
    <dbReference type="OMA" id="HEYERRS"/>
    <dbReference type="OrthoDB" id="4226666at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052973">
        <property type="entry name" value="Fungal_sec-metab_reg_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392:SF5">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="456"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="403"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="288"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="365"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="416"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS20523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="925" mass="101449" checksum="414EE98DC3C97588" modified="2011-10-19" version="1">MASASVRSVGSSPVSFSSYQQVDFSPSDNTAAPLDDTATGGDAELWDFVSQLSAGSVRGDGQSNGLLASPASVSQSLASSWVIVGPQGAFTTPSSQLPSSQEFDRLSELSGRVSLPAGAGRERGGAFGSVTSPPVAESSPFASQSLGQSGNVLFDQDLLNSWTSDAHFNGKLTRFSLLCWSGFLVANLFAAEWNILLSGVNNSSSVIEGQQILNSSLNLFNQQPVPLPSNASPWAPPNLRGSSKNNLSDLITGSLPSPNLANEDIAFSSPAASYRHSPFAISETVHTPASSGSAPPQSPSPAQVSIVREEPRRSPTAVPTTPPTTIPRTAPIPIIKPNNSAHRVQKRKASTATAVSFPSHHRNLSSSPAGSSGSGSISASPTTTSPSTTTANKFVVVTPSIISQHKDKPGNPWEEALASLSSSSSASSLRPTQRGRKGPLAEESRKAALDVRRKGACFHCHARKVGCDAQRPCKNCMRLAQQVPQVVCWRFPDFSIILFPEFIRGHLRKEKVAQFVADNVESFTVGGVEMPCDVELFSGFGMRAVLKLRAKFFTAKGADALQHWHAQLRNNEMALTLRGAAPIALEMGGMAGNDGGGSGSGDTQRSELKKKLKEYINAIVDEPWFPELMTPPPHHTEIPRKVLRIVHEYERRSKLPVVRSALSIYAMHYVMTRQLCMTRDNLAKLQPTGLVPNAPGMPFVTPRVLNRQIKAVLDDMMRHEMDKVFDDFARSVRRKMRNKWAPCLAAFLVLCLFMETVEVAADLFVISDTEIKLRQRSTPEWQRSFVLQVNQEIENMPFKQFAFQFHQVYQTHTRDATVRRFNPLLDDDCFEPGELEEEAADMVRKLRRLIDEDCRFVLLLVTLQERVANEMVTGDELDYLTADPILPNIEPHPYPRNVSYNYIGRLVTKFLLSFTDERYIFDNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G0S575</accession>
    <name>G0S575_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase II subunit 1</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">ATP-dependent DNA helicase II subunit Ku70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CTHT_0032510</name>
    </gene>
    <organism evidence="23">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ku70 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693690.1">
        <property type="nucleotide sequence ID" value="XM_006693627.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S575"/>
    <dbReference type="GeneID" id="18257289"/>
    <dbReference type="KEGG" id="cthr:CTHT_0032510"/>
    <dbReference type="eggNOG" id="KOG2327">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_240591_0_0_1"/>
    <dbReference type="OrthoDB" id="3249161at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00788">
        <property type="entry name" value="KU70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01458">
        <property type="entry name" value="vWA_ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000071">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.290.10:FF:000001">
        <property type="entry name" value="X-ray repair cross complementing 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.970.10">
        <property type="entry name" value="Ku70, bridge and pillars"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006165">
        <property type="entry name" value="Ku70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027388">
        <property type="entry name" value="Ku70_bridge/pillars_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047087">
        <property type="entry name" value="KU70_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005160">
        <property type="entry name" value="Ku_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00578">
        <property type="entry name" value="ku70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF2">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03730">
        <property type="entry name" value="Ku_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="SAP" evidence="21">
        <location>
            <begin position="618"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="895"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1166"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1352"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1471"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1557"/>
            <end position="1648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="912"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="984"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="1356"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="1395"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1410"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="1478"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="1509"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1557"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="1586"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="1602"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="1632"/>
            <end position="1644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EGS21394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1710" mass="186657" checksum="28B10EFFBB357CD0" modified="2011-10-19" version="1">MAYGDDDDDRRQDEEEEELDETDYKTQKDAVLFAIDVSASMLRPPSPATSNDKKAAATDRDSAVAAALKCAYKVMQQRIIAQPNDMMGVLLFNTHKSKFREEQPGGHTGAAYPHCYLLVDLNVPGADDVKRLRALAEDGDDPEGILVASDEPVSMANVLFCANQVFTTNAPNFGSRRLFIITDNDDPHAKDKSAKSSAAVRAKDLYDLGIVVELFPITRGEDKFDLAKFYDDIIYRDPAVEAIMPDAVKTSRAGDGLSLLNSLISNINSKQTPKRSFFSNLHFELAPGLTISIKGYQILHRQKPQRTYPIWMGGEKPMLAHPEAVRVDSEARTVDKSEIMKAWKFGGEFIRFKPEEAAALREFGSKVLRLIGFKPRSMLPSWASVKKSVFIYPSEELFVGSTRVFSALWQKLLKDDKIGIAWFIPRVNSQPQIVAIIPSENPDEEGAATPYLPAGLWLYPLPFADDVRKVDASAPPKKADELATKMREIVGNLQLPKGIYNPLKYPNPALQWHYRVLQAMALEDEVPDENDKEDLTIPKYRQIAKRVGGYMAEWKELLEEKTKAFIKSRALKREAEDEDGGRPVAKRARTVPTIKEGSVSGSKTGNAKLKEMFENGTLKNMTVADLKDVLASKGVSATGKKGQLLEKLEQWIEQNLSARRVTKYPSPDIWLIYVMEALLGASTTNSSCASIADLQIQLRNLLNARVTPTRAEHISATFEIRASAIFDIPGNETLNNAPHIDPQLAGVASSAAPSVAENGALATTYRVTAIDALMNQPRDDPKLQTSISKHIINSLSEVDASTWTVRHVGPSEHGWTFTYICKDSWQSWSRQVAKTPAKTLIGEWSERAGQDPIHMARPAFDCRGSVKISFVRSTRTIDVKYEHTPLHKTVGELIDLLAPPPPAPVSKTPVKKPKEPKPKEPKETKPRTSKPSKRGPGENGVPLDGKSSRQFKKRRKKDSLPPGAGVIPSEMPNDLPVGELSTRPLYNSHSEASTHGQPAGSSSYPETLVSTDGPAPEDVDALMGAILNLPPREIQRRRDVAIKLLTNSGIDPKTLTAEQFNIFANQSPELQQDSLAMFMKYGAERLRIVHPNQDSTPAATPNKNVAGEGTPVKQARSICDNCRIMKLRGKCDKALPACTLCVASGVACVYTKPWKSQVAEGATSDAIAAPGAPGPPAPEDAANNELGNLGSPGFRSVPAAEPAPPIDPQGNGPAQDQVHDHLVSHVAEPVNEPVAAKPVHQQLELTSDPFSQYRRSSGVSLLPQAAATAVPGQLAHPSIPTASVDSNPLDYIHNSIPEATDGERAVDDITAELFNNAAHKWGWNKQYYNEYTTKHLAVPVRANSAPVSQAYDDLHQQQQASTSWSTQASQQAVWPSPPQTAVQPVRSRSRQPGRSQAQTQSSSMATAQQGNQSLPITSGPTQQSSSTRSYNYNQYSTGSSQADRSNDHIAYQSYGTGPTAVQLTTHPLVDGYSSRLPSTSVTHSSTSSSQKMTQTYSTTFSANTSQWGTASSTAQQTKSSRGYCTTQSTASSTASYNLPPTTQQFQSVQGFDMFPQVQPQARSSSSLYTQRTQKPQQQTYSSYIAQSQQDHQQPQQHHHQQQSHQQQQHFQRTAAASTTLHRHQRTTWGGYSTSTTSSTATTSSRFGSLTATAGTGKAYSSAVHERQHHWSTLAELGLRAAVAAAGKCAGTGAGAMDGDHALYDLVGNNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5A1</accession>
    <name>G0S5A1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Squalene monooxygenase</fullName>
            <ecNumber evidence="16">1.14.14.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CTHT_0032780</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>squalene + reduced [NADPH--hemoprotein reductase] + O2 = (S)-2,3-epoxysqualene + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25282"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:15441"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 16">Endoplasmic reticulum membrane</location>
            <topology evidence="3 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the squalene monooxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.17" evidence="16"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693716.1">
        <property type="nucleotide sequence ID" value="XM_006693653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5A1"/>
    <dbReference type="STRING" id="759272.G0S5A1"/>
    <dbReference type="GeneID" id="18257316"/>
    <dbReference type="KEGG" id="cthr:CTHT_0032780"/>
    <dbReference type="eggNOG" id="KOG1298">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026390_0_0_1"/>
    <dbReference type="OMA" id="AKRTFYW"/>
    <dbReference type="OrthoDB" id="1678617at2759"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00752"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004506">
        <property type="term" value="F:squalene monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000166">
        <property type="entry name" value="Squalene monooxygenase Erg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013698">
        <property type="entry name" value="Squalene_epoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040125">
        <property type="entry name" value="Squalene_monox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835:SF0">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08491">
        <property type="entry name" value="SE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 16" id="KW-0274">FAD</keyword>
    <keyword evidence="5 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="441"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="17">
        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene epoxidase" evidence="18">
        <location>
            <begin position="196"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGS21420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="499" mass="55113" checksum="1E0359A3EE79CFB4" modified="2011-10-19" version="1">MATKTVTKADKARVVERREQHHEADVVVVGAGVFGCAIAYALANQGRSVILLERWMHEPDRIVGELLQPGGCETLRKLGMGDCLEGIDAAPCYGYHVIYRGEEVSFPYPPVDKHGNIIWNADVTKFTSRPEGRGFHHGRFIMNLRRKCLNHENISVFETEVTATIKDTHSKAVLGVQTQTKDPKTGKKKPDCFFGSLTIIADGYASIFRKELLGTEPVVRSKFYGLELIDCQLPSQGYGHVVIGDGALALLYQIGTHETRALIDVPLDAAKPETGGVRGYIERVVLPALPPQVQPAVRKAMADGKIPKSMPNSWLPSCKQTRNDGVILLGDAHNMRHPLTGGGMTVAFNDAYLLSQLLHPERVPDLADYNAVHSAMSTFHWKRKSLTSIINVLAQALYSLFAADDWQLRALQKGCFRYFQLGMTEAPVSLLGGLLQRPLTLAYHFFSVAFLAIWLNMIDCCSGKGVLGVFMLPVALVQAVMIWWKACVVFLPVFATELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5A2</accession>
    <name>G0S5A2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor RSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Pre-mRNA-splicing factor rse1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0024090</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2016" name="Mol. Cell" volume="64" first="307" last="319">
            <title>Molecular architecture of SF3b and structural consequences of its cancer-related mutations.</title>
            <authorList>
                <person name="Cretu C."/>
                <person name="Schmitzova J."/>
                <person name="Ponce-Salvatierra A."/>
                <person name="Dybkov O."/>
                <person name="De Laurentiis E.I."/>
                <person name="Sharma K."/>
                <person name="Will C.L."/>
                <person name="Urlaub H."/>
                <person name="Luhrmann R."/>
                <person name="Pena V."/>
            </authorList>
            <dbReference type="PubMed" id="27720643"/>
            <dbReference type="DOI" id="10.1016/j.molcel.2016.08.036"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.90 ANGSTROMS) IN COMPLEX WITH CA(2+)</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing and cell cycle control.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RSE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692871.1">
        <property type="nucleotide sequence ID" value="XM_006692808.1"/>
    </dbReference>
    <dbReference type="PDB" id="5HY7">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="A/B=1-1213"/>
    </dbReference>
    <dbReference type="PDBsum" id="5HY7"/>
    <dbReference type="AlphaFoldDB" id="G0S5A2"/>
    <dbReference type="SMR" id="G0S5A2"/>
    <dbReference type="STRING" id="759272.G0S5A2"/>
    <dbReference type="GeneID" id="18256447"/>
    <dbReference type="KEGG" id="cthr:CTHT_0024090"/>
    <dbReference type="eggNOG" id="KOG1898">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003246_0_0_1"/>
    <dbReference type="OMA" id="PRATGHW"/>
    <dbReference type="OrthoDB" id="436637at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001143">
        <property type="entry name" value="Pre-mRNA-splicing factor rse-1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000068">
        <property type="entry name" value="Pre-mRNA-splicing factor rse1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="16" id="KW-0002">3D-structure</keyword>
    <keyword evidence="16" id="KW-0106">Calcium</keyword>
    <keyword evidence="16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="12">
        <location>
            <begin position="21"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="13">
        <location>
            <begin position="465"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="11">
        <location>
            <begin position="856"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="671"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="916"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="1180"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS20575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="5HY7"/>
        </source>
    </evidence>
    <sequence length="1213" mass="134365" checksum="875111BBA2D83C8E" modified="2011-10-19" version="1">MATTTSNMFLYSLTIQPPTTITQALLGQFSGTKEQQIITASGSRLTLLQPDPRQGKVNTIVSHDIFGIIRAMAAFRLAGSHKDYIILATDSGRIAIIEYLPKENRFQRIHLETFGKSGVRRVIPGQYLAADPKGRACLIASVEKNKLVYVLNRNAQAELTISSPLEAHKPGVIVLSLVALDVGYSNPVFAALEYEYSEADQDPTGQAAKQLEMQLVYYELDLGLNHVVRKWSDTVDPTSSLLFQVPGGNDGPSGVLVCGEENITYRHSNQEAFRVPIPRRRGATEDPNRKRTIVAGVMHKLKGSAGAFFFLLQTEDGDLFKVTIDMVEDEKGNPTGEVKRVKIKYFDTVPIAHSLCILKSGFLFVASEFGNHHFYQFEKLGDDDDEPEFTSDDFPADWNAPYNPVYFKPRPLENLVLVESIDSMNPLVGCKVANLTGEDAPQIYAICGNGARSSFRMLKHGLEVSEIVASELPGTPSAVWTTKLTKYDEYDAYIVLSFTNATLVLSIGETVEEVSDSGFLTTVPTLAVQQMGEEGLIQIHPKGIRHIVQGRVNEWPAPQHRSIVAATTNENQVVIALSSGEIVYFEMDADGSLAEYDEKKQMSGTVTSLSLGKVPEGLRRSSFLAVGCDDCTVRILSLDPESTLEMKSIQALTAAPSSLLIMSMEDSTGGTTLYLHIGLHSGVYLRTVLDEITGELTDTRQKFLGPKPTKLFQVTVQNQTCVLALSSRPWLGYTAPITRNFVMTPLSYTELGYTWSFNSEQCQEGMVGIHANYLRIFTIEKLGQTMIQKSCPLTYTPKRLVKHPEQPYFYVIEADNNTLPPELRAQLLEQSGAVNGDATVLPPEDFGYPKARGRWASCIEIVDPVSEEQPRVLKRIELEGNEAAVSAAVVPFASQDGESFLIVGTGKDMVLNPRASTEGAIHVYRFIDDGRDLEFIHKTIIEEPPLAFCPFQGRLLAGIGKMLRIYDLGLKQLLRKAQAEVSPQLIVSLDTRHNRIVVGDVQHGMTYVVYKPDSNKLIPFADDTIARWTTCTTMVDYESVAGGDKFGNLWIVRCPERASLESDEPGSEVQLLHARPYLHGAPNRLDLMAHFYPQDLPTSICKTNLVVGGQDVLVWSGIQGTVGVLIPFVTREDADFFQNLESHMRAEDPPLAGRDHLIYRGYYVPVKGVIDGDLCERFTLLPNDKKQMIAGELDRSVREIERKISDIRTRSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5G1</accession>
    <name>G0S5G1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plasma membrane channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0032840</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693722.1">
        <property type="nucleotide sequence ID" value="XM_006693659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5G1"/>
    <dbReference type="STRING" id="759272.G0S5G1"/>
    <dbReference type="GeneID" id="18257322"/>
    <dbReference type="KEGG" id="cthr:CTHT_0032840"/>
    <dbReference type="eggNOG" id="KOG2513">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010867_0_0_1"/>
    <dbReference type="OMA" id="YNGPLKT"/>
    <dbReference type="OrthoDB" id="296386at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049456">
        <property type="entry name" value="Anoctamin_N_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF73">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20877">
        <property type="entry name" value="Anoctamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="381"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="579"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="620"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin alpha-beta plait" evidence="7">
        <location>
            <begin position="17"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="6">
        <location>
            <begin position="188"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS21426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="743" mass="84672" checksum="A01ACE00B2157691" modified="2011-10-19" version="1">MAPSERSDQDLSKSNFDVDYVIHYEIPPTATAEAEAAFIQLITALSSTGFTTEVRRGRKPSSLLIFTKLASPNLLRNQVYRARVQDWLYGVRPDAPAKITAEGESEESEPITPAERLRVAYLLITRPKDEGGAGVSPANVASSSPGVSPAYNRFVKSIFAPHDKAFNRTWLAKWTSKYQPDDNDLSEIRDQFGEKVALYFAFLREYSRFLLFPAAFGFAAWLLLGPYSWVYAVVNALWGVVFFEYWKVREEDLAVSWGVRGVGRIQHPRPQFKWEREGIDPVTGQVVKVYSPVKRFLRQLLQIPFAAACVVALGGVIVSCFAIEIFITEVYNGPFKQYLTFLPTIILTIFNPTFTALLTILAERLTELENYETQDAHMASFVQKIFVINFITSYLGIFLTAFVYVPFAKVLVPYLDIFQFTVQKFTPEGVALPTKSWEINPDRLTKQVIYFTVTAQIVNLAMEVIMPWAKRKAFKTVEKVQAERNNEKPIETQFKDDPQEAEFLERIRDEAELEEYDVTIDYREMVIQFGYLSLFSVVWPLTAISFIINNWIEARSDAVKIITHCQRPIPWRSDTIGPWLRSLGFLSWLGSITSSALVFLFHHHHGGAHIDDYSPWDIPFWALLLTIMFAEHVYLGVQIVVRGVLRKVVETPGLEKERAERFALRKMFERTGGVGGVEGGKASEQVGGEKITRESLEDDARRLAEVEGMPEKMFWLRQRNPDETIQVGRAMIAEFANHTRAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5N5</accession>
    <name>G0S5N5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0024900</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692950.1">
        <property type="nucleotide sequence ID" value="XM_006692887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5N5"/>
    <dbReference type="STRING" id="759272.G0S5N5"/>
    <dbReference type="GeneID" id="18256528"/>
    <dbReference type="KEGG" id="cthr:CTHT_0024900"/>
    <dbReference type="eggNOG" id="KOG1989">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011638_0_0_1"/>
    <dbReference type="OMA" id="MDSHASQ"/>
    <dbReference type="OrthoDB" id="2018507at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14037">
        <property type="entry name" value="STKc_NAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000441">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967:SF57">
        <property type="entry name" value="AUXILIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="67"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="349"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="540"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="766"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="881"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="445"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="540"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="560"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="611"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="723"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="805"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="836"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="881"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="902"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="950"/>
            <end position="974"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS20654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1102" mass="118927" checksum="723AC4A16CAD748C" modified="2011-10-19" version="1">MASYGQAAPRPASHHHAAAAAAYAAHPMAAAAPAAVPHAAMPGHGGPVPPPGTFAPGTKIQVGNHRVVVQKYLSEGGFAHVYLVKLPAPINGTDLAVLKRVAVPDKESLRGMRTEVETMKRLKGHRAIVTYIDSHASELRGGGYEVFLLMEYCNGGGLIDFMNTRLQHRLTEPEILTIFADVAEGVACMHYLRPPLLHRDLKVENVLITLVGNTRRFKLCDFGSAAPPRPAPTTAAECRAIDEDVQKHTTMQYRSPEMVDVYRKLPIDEKSDIWALGVLLYKLCYYTTPFEEQGTLAILNASYKFPSYPVFSDRLRGLIAWMLQENPQARPNIYQVLREACAMQGREPPIKDIYSGRTQPTPQQVIPEVERMRRGRVPAPQPASRPTASPPKVTNGDPFAALDGKTLPLPGADELSSRFPTLDEFTLLHDRGQKFNFDSSNFPSPSLPQQPLPPQPQPHLQQRVVERLADEAFQIKPVVLPPALAPAPVSNRQSVEMKRTSMYKPPPLDTSLVSSPPRQPEISRASAIIQSTPELQAISNQAQAAMAQAEAPKPKPIMVSTGTMTSPTLEQAPPFPSTTTRVPSTERHRAASLPKSPTGHNSSLLGVDSPMSRTASRAPSYSSLARQPSHDRHPSSSRPSLEGGRPNLENVDVGRPMSRLAAKPRPVSTHLESNLDFLREQEARSRSPALPSPRHSLERRSLERSSPPSPAEQETTIESNVEFLRKLEEPDKKKDRTSKHLKRSSLSSLAGGTKAILSGKFSEAFKRFESSSSSQPARAPSPLKELERRELTPIPGSEPSIDDGSDGRRSPDWEDMTPEQRREHEARLLAQEEARVAAAQAEYRARVAQRTDGTSNPTPLPKSIGGVSRAVSIQNKVQSLLEESTRSSTTVPRTAQGYGHYSDAAHAASAATAQSTSGSPTRPQTSAASDGRPTVPRKPVSASIAAAQITGSSSTVPRPPTSSSIEPSSTGRSTVRPVAPPKPTHLITSATGGAGGAGAGIRPPSPGKHLSLPAMPGKLRSTGSNQGLGISTGTSGSTTEALLAVDLPGMKGPALLEMTEAEKDDYIRDFQKRFPNLEAIEMVETDVSAWDGRSSAGKGRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5P6</accession>
    <name>G0S5P6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative 2 iron, 2 sulfur cluster binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0025010</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the adrenodoxin/putidaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692961.1">
        <property type="nucleotide sequence ID" value="XM_006692898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5P6"/>
    <dbReference type="STRING" id="759272.G0S5P6"/>
    <dbReference type="GeneID" id="18256539"/>
    <dbReference type="KEGG" id="cthr:CTHT_0025010"/>
    <dbReference type="eggNOG" id="KOG3309">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082632_0_2_1"/>
    <dbReference type="OMA" id="QSPWQGY"/>
    <dbReference type="OrthoDB" id="268593at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140647">
        <property type="term" value="P:P450-containing electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001055">
        <property type="entry name" value="Adrenodoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018298">
        <property type="entry name" value="Adrenodoxin_Fe-S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426:SF65">
        <property type="entry name" value="FERREDOXIN-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426">
        <property type="entry name" value="FERREDOXIN/ADRENODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00355">
        <property type="entry name" value="ADRENODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00814">
        <property type="entry name" value="ADX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="7">
        <location>
            <begin position="90"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS20665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="202" mass="22341" checksum="5F0CD7A5E242E586" modified="2011-10-19" version="1">MATSRTFAQALPSLGLAATRTPVRPIAQYLWTYTTASAALRLSSITRGSQLPMMRRQIQMTRSLQQTRAFSASAATSHGHIEPPKPGEELWVTFIDKEGNEHKLAVKEGDNLLDIAQAHDLEMEGACGGSCACSTCHVIVLDQEYYDRMPEPDDDENDMLDLAFGLQETSRLGCQVHMTKDLDGLRVKLPAMTRNLQASDFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5W8</accession>
    <name>G0S5W8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0025200</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692980.1">
        <property type="nucleotide sequence ID" value="XM_006692917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5W8"/>
    <dbReference type="STRING" id="759272.G0S5W8"/>
    <dbReference type="GeneID" id="18256558"/>
    <dbReference type="KEGG" id="cthr:CTHT_0025200"/>
    <dbReference type="eggNOG" id="ENOG502S756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060567_0_0_1"/>
    <dbReference type="OMA" id="DQIWPGQ"/>
    <dbReference type="OrthoDB" id="2107166at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.60.10">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011058">
        <property type="entry name" value="Cyanovirin-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036673">
        <property type="entry name" value="Cyanovirin-N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008816">
        <property type="entry name" value="Gly_zipper_2TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37014">
        <property type="entry name" value="EXPRESSION LETHALITY PROTEIN HEL10, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37014:SF1">
        <property type="entry name" value="EXPRESSION LETHALITY PROTEIN HEL10, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08881">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05433">
        <property type="entry name" value="Rick_17kDa_Anti"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01111">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51322">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="219"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS20684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="327" mass="35297" checksum="4F443407BF6CF093" modified="2011-10-19" version="1">MTSYNQYGQGEAASYYQSAQQAYNQQSQRKRSDSDGSDGPSGDRGILGGIAGGVAGAVGGNKLGGKAGHSKLGTVLGAVAGAVAGHKLQDEVSEKIDEKKKKKEEEEAKKKREEEEKRRREEEEKRRREEQLKQKQRRDSSPSPSRNRNYAGGFSGSARDIRLENSGGDWILRASCRCRDGSYRDSTISLNKLLENDNGSFRWSSGRSAGGGHCAPAPQTYTVQPGDTLRAIAARFPGCGTFEDIARVNNIPNPDLIYPGQVLQIPGGQAPQHHAGGNFGASARNVRLSDGGRRLEAELCRADGRYVSASVILDERIGNDNGTLVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6I0</accession>
    <name>G0S6I0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 12">Adenylosuccinate synthetase</fullName>
            <shortName evidence="10">AMPSase</shortName>
            <shortName evidence="10">AdSS</shortName>
            <ecNumber evidence="10 12">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0026290</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Plays an important role in the de novo pathway of purine nucleotide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10 12">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 12">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="10 12"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693087.1">
        <property type="nucleotide sequence ID" value="XM_006693024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6I0"/>
    <dbReference type="STRING" id="759272.G0S6I0"/>
    <dbReference type="GeneID" id="18256667"/>
    <dbReference type="KEGG" id="cthr:CTHT_0026290"/>
    <dbReference type="eggNOG" id="KOG1355">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029848_3_2_1"/>
    <dbReference type="OMA" id="FHHAKPI"/>
    <dbReference type="OrthoDB" id="10265645at2759"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046040">
        <property type="term" value="P:IMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.300.10:FF:000001">
        <property type="entry name" value="Adenylosuccinate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.170.10:FF:000001">
        <property type="entry name" value="Adenylosuccinate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033128">
        <property type="entry name" value="Adenylosuccin_syn_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002223">
        <property type="entry name" value="PRK01117.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00184">
        <property type="entry name" value="purA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846:SF0">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00513">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 10 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 10 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10 12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="40"/>
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            <begin position="11"/>
            <end position="17"/>
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        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
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        <location>
            <begin position="12"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>IMP</name>
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        </ligand>
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        <location>
            <position position="12"/>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
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        <location>
            <begin position="37"/>
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        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
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        <location>
            <begin position="39"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
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        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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        </location>
        <ligand>
            <name>IMP</name>
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        </ligand>
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        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
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        </location>
        <ligand>
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        </location>
        <ligand>
            <name>substrate</name>
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        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
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        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
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        </location>
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        <ligand>
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        </source>
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        </source>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
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        </source>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_03125"/>
        </source>
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        </source>
    </evidence>
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            <dbReference type="RuleBase" id="RU000520"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGS20791.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="423" mass="46997" checksum="8CDD40FD58EEFF05" modified="2011-10-19" version="1">MTTIILGSQWGDEGKGKLSDILCQKAQICARAAGGHNAGHSVVANGVEYDFHLLPSGLVNPDCINLIGSGVVFNVQAFFKELETLEAKGLTHARKKLLVSDRAQVNLELHARVDGLEERELANQKIGTTGRGIGPSYSTKAARNGIRVHEIFDQEHFEAKLRRLAAGYKKRFGDLLEYDVEEEIARFREYRKKLPEFVVDAVNFMANAQKNGVEILVEGANALMLDIDYGTYPFVTSSNTGLGGVITGLAINPRTIKEIIGVAKAYTTRVGEGIFKTEDTGEVGQKLQQIGREWGVSTGRKRRCGWLDLVVLKYSASVNYYTAWNLTKLDVLDTFPTIKVAVAYKDPETGAELDYFPADLSYLEKCEVVYKELEGWMKPTTSVRKWEDLPPQAQAYVKFIEEFTGVPVKWIGTGPARDDMIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6I1</accession>
    <name>G0S6I1_CHATD</name>
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        <submittedName>
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        <name evidence="2" type="ORF">CTHT_0026300</name>
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        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
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                <person name="Hurt E."/>
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            <dbReference type="PubMed" id="21784248"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="term" value="F:phosphoric diester hydrolase activity"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="42"/>
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            <begin position="43"/>
            <end position="387"/>
        </location>
    </feature>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="387" mass="41750" checksum="47EAF4FD3D2FE663" modified="2011-10-19" version="1">MLGLPSYHSLLTYFRPSSMTMMTASLRNFLFLLLALPNPGAASPNLLPRQTITNAAPQICNNSPDLCSRTYTNITHLGAHNSAFVRDASTGNSIAGNQFYNATVALSAGVRLLQAQVHRLDDGTLELCHTLCSLMDAGPLDKWLEKIRYWMDQHPDDVVTLLLVNSDDASVEEFGAAFEKAGIAKYGFVPPSPSEGYAAWPTLAGMIAAGTRLVTYIASITASSQYPYLLPEFDYVFETPYNILSLDGFGCDLDRPSSAGTATNAISKGMLPLLNHFAYTSLTSDIQIPDASDVNTTNSPSTTTTGALGLHVNNCTGLWGVKPVYLLVDFYNRGPSIDTADRLNGIQPVGREKEPSGSSATALWTRFLSAQGLVVFSVFWGLVLSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7E8</accession>
    <name>G0S7E8_CHATD</name>
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        <submittedName>
            <fullName evidence="3">Putative tropomyosin protein</fullName>
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        <name type="synonym">Thermochaetoides thermophila</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20950.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006693183.1"/>
    </dbReference>
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    <dbReference type="STRING" id="759272.G0S7E8"/>
    <dbReference type="GeneID" id="18256827"/>
    <dbReference type="KEGG" id="cthr:CTHT_0027890"/>
    <dbReference type="eggNOG" id="KOG1003">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104738_0_1_1"/>
    <dbReference type="OMA" id="EQWETKY"/>
    <dbReference type="OrthoDB" id="128924at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000114">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000001">
        <property type="entry name" value="Tropomyosin alpha-1 chain isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19269">
        <property type="entry name" value="TROPOMYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS20950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="161" mass="18860" checksum="209F65856D75E80A" modified="2011-10-19" version="1">MDRIKEKMNQLRLEAEEATAKVEELQAKIKQLEQENLQKEQEIISLTHKNSVLEAEVEKLEAQVKELKAQASEGQQAGTQNEALTRRLQLLEEEAEEADRTLREANEKLRQTDVRAGHFERKVQALEQERDQWEAKYEEMARKYAQVQKELEEFQNEIAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7T6</accession>
    <name>G0S7T6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0028760</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693332.1">
        <property type="nucleotide sequence ID" value="XM_006693269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7T6"/>
    <dbReference type="STRING" id="759272.G0S7T6"/>
    <dbReference type="GeneID" id="18256914"/>
    <dbReference type="KEGG" id="cthr:CTHT_0028760"/>
    <dbReference type="eggNOG" id="KOG1284">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029639_1_0_1"/>
    <dbReference type="OMA" id="FQQLMPD"/>
    <dbReference type="OrthoDB" id="57939at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="entry name" value="GTP cyclohydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022163">
        <property type="entry name" value="GTP_CH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005536">
        <property type="entry name" value="PRK07198.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259:SF2">
        <property type="entry name" value="URACIL-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12471">
        <property type="entry name" value="GTP_CH_N"/>
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        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="RibA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase N-terminal" evidence="3">
        <location>
            <begin position="99"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="2">
        <location>
            <begin position="327"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS21036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="500" mass="55361" checksum="7214D0243918BFC7" modified="2011-10-19" version="1">MSSNLDDVKQALKAISEQTAQVLSAVSAISQRVEKLEKAQEENHRQQQPNGTRANADVEKRAATPLAGGFTPSSSTVMPAEAGTQSPPPSSVKSGFSTRVVLTTYPKQIGINPIPLNWGAADPHERGPVTVLRSPSTIGRRNAIGAHAGSYSIYYALALASRELKADHRPDFTNTEPAVNIGPFPQWGDPKKIVAMDPWGHLVPWIFKDKIEKEGVDLRPTIAITKAHMKLPELEDSVKSGRLVPDGKVCLNNEGELNVTKIAVEPVWYLPGVAERFGIDEGTLRRSLFEYTGGMYPELITRPDMKVFLPPIGGLTVYIFGDPARVSDPSKRLALRIHDECNGSDVFCSDICTCRPYLIFGIEEAVKEAQNGGSGVVIYFRKEVVYNARKRGQDRASDYFKRTENIAGVKDMRFQALMPDILHWLGITKIDRMLSMSNMKHDAIVGQGIPIYERVELPEHMIPADSRVEIDAKINAGYFTTGHRMTEEELKSVQGRIWEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7U7</accession>
    <name>G0S7U7_CHATD</name>
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        <submittedName>
            <fullName evidence="8">Putative transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0028870</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693343.1">
        <property type="nucleotide sequence ID" value="XM_006693280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7U7"/>
    <dbReference type="STRING" id="759272.G0S7U7"/>
    <dbReference type="GeneID" id="18256925"/>
    <dbReference type="KEGG" id="cthr:CTHT_0028870"/>
    <dbReference type="eggNOG" id="KOG1414">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_865998_0_0_1"/>
    <dbReference type="OMA" id="HAKCNDR"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="205"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="132"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="223"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS21047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="321" mass="36289" checksum="724A078775188311" modified="2011-10-19" version="1">MSFAGELMATEATSQFFADSVSFDDQPSYESPDQDVDTSNINLSTPYIDTRLDIGGAPLVLDGFVSSTPQDSEPRTDVWDGFAEQGDMMGPEQRPFFIDPDLYGPGSEVDQTLQQQYTLATGPVEDFRQSFPRTVSSRSLSLQTSTSGSISTGITLPEQLADQPEKPIRQKRQQGEQEEQEEAQDPPRKRRTRKTKRETVSAEDEEKRNRFLERNRIAASKCREKKKLYVMELEEAKNGLEQKNARLQFERDSLVLEIGQLKHQLMAHASCNDPNIDTWINREARKYVEESAGREEEARTSNDEAWSPLNTSYAALSFPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8B2</accession>
    <name>G0S8B2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0038220</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006694179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8B2"/>
    <dbReference type="GeneID" id="18257860"/>
    <dbReference type="KEGG" id="cthr:CTHT_0038220"/>
    <dbReference type="HOGENOM" id="CLU_1081833_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="257" mass="28250" checksum="8A3D975554AFADA2" modified="2011-10-19" version="1">MLPTTATIVATVCADIDWVALWNRIPKEEKHNKDTPWDVTFSQGIVNGTIVIKGFNPRTRRAQRERVRRNCENRNTLSAPVDQPMMGEEANAPTIQQPLAQPTTKRADNDLTPAKAHSQRRRQTDSTESRQNPSFTTSVDFKAPSKTVEELLTLDHERPSSPASSDIGEPEFCPLPIKLATSIVPDQAPNTNIWPIDGLLDFTGRCINCFAPEIDPASGIPHVCRAPCKYCGAASSLHLPATFPFKALACTCSAFPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8E0</accession>
    <name>G0S8E0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mediator of RNA polymerase II transcription subunit 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0029550</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2021" name="Mol. Cell" volume="81" first="1781" last="1788.e4">
            <title>Mediator structure and conformation change.</title>
            <authorList>
                <person name="Zhang H."/>
                <person name="Chen D.H."/>
                <person name="Mattoo R.U.H."/>
                <person name="Bushnell D.A."/>
                <person name="Wang Y."/>
                <person name="Yuan C."/>
                <person name="Wang L."/>
                <person name="Wang C."/>
                <person name="Davis R.E."/>
                <person name="Nie Y."/>
                <person name="Kornberg R.D."/>
            </authorList>
            <dbReference type="PubMed" id="33571424"/>
            <dbReference type="DOI" id="10.1016/j.molcel.2021.01.022"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (4.20 ANGSTROMS) OF 3-137</scope>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Mediator complex subunit 21 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693410.1">
        <property type="nucleotide sequence ID" value="XM_006693347.1"/>
    </dbReference>
    <dbReference type="PDB" id="6XP5">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.20 A"/>
        <property type="chains" value="U=3-137"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8E0"/>
    <dbReference type="EMDB" id="EMD-22284"/>
    <dbReference type="SMR" id="G0S8E0"/>
    <dbReference type="STRING" id="759272.G0S8E0"/>
    <dbReference type="GeneID" id="18256993"/>
    <dbReference type="KEGG" id="cthr:CTHT_0029550"/>
    <dbReference type="eggNOG" id="KOG1510">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094271_1_1_1"/>
    <dbReference type="OMA" id="LTTYHDH"/>
    <dbReference type="OrthoDB" id="526653at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.10">
        <property type="entry name" value="Mediator complex, subunit Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021384">
        <property type="entry name" value="Mediator_Med21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381:SF0">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381">
        <property type="entry name" value="RNA POLYMERASE II HOLOENZYME COMPONENT SRB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11221">
        <property type="entry name" value="Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="15" id="KW-0002">3D-structure</keyword>
    <keyword evidence="6 10" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="92"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS21114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="6XP5"/>
        </source>
    </evidence>
    <sequence length="137" mass="15887" checksum="F0F4E5379C197663" modified="2011-10-19" version="1">MGDRLTQLQEAMDELLEMFLSAFFWVERHHDLKTFGPNDKIPDLKADQPKEVDTKSPEEYKAGQLQLARDIIVKEQQIEYLISTLPGLDNSEREQIQLLRELEDDLVTAEAQRQEALKERDEVLGKLDALLRGLERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8I6</accession>
    <name>G0S8I6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0030020</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693456.1">
        <property type="nucleotide sequence ID" value="XM_006693393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8I6"/>
    <dbReference type="GeneID" id="18257040"/>
    <dbReference type="KEGG" id="cthr:CTHT_0030020"/>
    <dbReference type="HOGENOM" id="CLU_401132_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="466"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS21160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="686" mass="78323" checksum="E6860347FB349E60" modified="2011-10-19" version="1">MITKILFSLLELLFPSYSAKIVESLLAISIFPILIFGGAALFPLALFYVFIWLTGNIFYPILSSLLDPFLRFIPFRLIYFLTIGWFFSLRDLIFGDPSRRHVPHDRAIPPEPWAFNNEGFLAPDAPRDRWGQQSWPEDRTPPDYWLAQPLSRLLYRWTPERPRRPSIETGRISARHAARHHSRRGIVRRSSSSVRSTGIPGPARHRPAASVESVSPSLMSLPRDAPFNEEEERQKLVQRQEEDKKRLIEKLQRRQRRLERECKKLEEQTKREREKLERLQQKQRDIFEMEVRDRKTHHGLMAMENAGNYHEIEYLRQGVLGNPHYRRLEMPSMESGEGMVEKIKEEEKNGKQKVIQKQQSQVNDKGKQLAQPEVESKVDVEGKQKEENVTKEAGDQANGQPAQNERRIFVSGESQAVNPRDNQTADQKNRDPKGKQKAPRLSSPSPTCPQPPQTQAPNPCEPSPPSSDDSQLSASSRFLNWFKRRIPSQPSGPEQVADRWKTLYPRRDSYGQPRGNPYGDLGDDEVIGVLVDSTASTPPNEELDRPFGRNPVGPVPLEWNPIDGPGRGNNHEQEGEEEQVRRPSVFETRARARRESRSRSRTREGKEGRESEQRGVSLEGGEVNGTQPEENDQARGSNGTEAGNAKPQADETQLHAAPLRRSRSMSKGETNSGLVDRVAGWWKGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8I9</accession>
    <name>G0S8I9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="5">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0038250</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = (6R)-5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="5"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694245.1">
        <property type="nucleotide sequence ID" value="XM_006694182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8I9"/>
    <dbReference type="STRING" id="759272.G0S8I9"/>
    <dbReference type="GeneID" id="18257863"/>
    <dbReference type="KEGG" id="cthr:CTHT_0038250"/>
    <dbReference type="eggNOG" id="KOG3093">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066245_2_1_1"/>
    <dbReference type="OMA" id="DKWGIPT"/>
    <dbReference type="OrthoDB" id="2015992at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10420:FF:000007">
        <property type="entry name" value="5-formyltetrahydrofolate cyclo-ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407">
        <property type="entry name" value="ATPASE INHIBITOR/5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00036539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS21949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="256" mass="27692" checksum="10A7B4D3543FDF36" modified="2011-10-19" version="1">MGDPIDEPSMASLNAAKQHLRAAMKQKLKALPHDAILSQSFKVYQTLRTLKPYANAKRISVFLSMPSGEIQTDAIVRDALATGKQVFIPYLHKNPAPAPGHPARVMDMVCLRDLADYESLKPDKWGIPSLDAATVRGRQRLFGDGPDGQPANELLLDLILMPGVAFDVSPNGDQIRRLGHGKGFYDYFLSRHEAKAASLGQQESPVLLYGLALSEQLLSPSEGAVPVGPHDKPLHGLILGNGEIKGPLAPPVNKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8N8</accession>
    <name>G0S8N8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0038790</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694294.1">
        <property type="nucleotide sequence ID" value="XM_006694231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8N8"/>
    <dbReference type="GeneID" id="18257917"/>
    <dbReference type="KEGG" id="cthr:CTHT_0038790"/>
    <dbReference type="HOGENOM" id="CLU_1023079_0_0_1"/>
    <dbReference type="OrthoDB" id="4684492at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="272" mass="31116" checksum="3975B3F8C144680C" modified="2011-10-19" version="1">MSDTAKGKISAMEKAITPSNVIEKGTSKRGRKPGVKTAAATPNDALTVASKATREVVPTEPFKQPFDEIFKEHTTDLGTTNSQKAPTTPKKTTKATSTTPAKPFELSVPVTFEEEDLRLTRQLGRILLEQLPVQNIAEFYDWIHSPIVQPQWEEFVADYFEYNIFAEEPDKRDVVETAERVIRFGKGKYLIYKPCKDDWTQEDHCIRFVVTVANNQMAQWGNVWPDIWKQHGWEITKALFEMLMYLRHTAKLKVQAKMSMFAKSSKKRNVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8Y3</accession>
    <name>G0S8Y3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative ribosomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0043860</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL41 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694779.1">
        <property type="nucleotide sequence ID" value="XM_006694716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8Y3"/>
    <dbReference type="STRING" id="759272.G0S8Y3"/>
    <dbReference type="GeneID" id="18258424"/>
    <dbReference type="KEGG" id="cthr:CTHT_0043860"/>
    <dbReference type="eggNOG" id="KOG4756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131055_3_0_1"/>
    <dbReference type="OMA" id="YIIEWDK"/>
    <dbReference type="OrthoDB" id="408933at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019189">
        <property type="entry name" value="Ribosomal_mL41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21338:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21338">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09809">
        <property type="entry name" value="MRP-L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS19894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="103" mass="11922" checksum="38A01A4DEBD87F4C" modified="2011-10-19" version="1">MKPSPILQVLRYRNLRLTTKDVGKGYYKGTRTGSMGRHTKYGGYVIEWHKVRTYVCPSLDGFKLTPFVSRKIPPTRGQYSGDQLGPKNPERYLQRWKSENGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0S962</accession>
    <name>G0S962_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0044690</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694858.1">
        <property type="nucleotide sequence ID" value="XM_006694795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S962"/>
    <dbReference type="GeneID" id="18258507"/>
    <dbReference type="KEGG" id="cthr:CTHT_0044690"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="OMA" id="NAIVIMF"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF48">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G01000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="63"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS19973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="511" mass="56719" checksum="0E6BF8C9B1358F8C" modified="2011-10-19" version="1">MAEDKRDISSESEKAVADHTEVTADQHAIAERGHAATDIYGNALIHIDPKAESKLRTKLDLFIVPTVSLLYLFCFIDRANIGNAKIAGFEKDIGLEGYDYNIVLTVFYISYVLFEMPSNILCKWLGPGWVLPALSLGFGIASVAMAYVKNFSQACGVRFVLGAFEAGLMPGIAYYLSRWYRRAELTFRLSLYIVMAPLAGAFGGLLASAILTLDHVADVSSWRMIFLIEGIITCGLSVIAFFTLTDRPETARWLTQEEKDLAIARIKAERVGTTEVLDKMDWKKLLRGISSPVVWATAICYGLNNITVQGLAFFAPTIVRTIYPDKTTVMQQLYTVPPYVVGGFFTLMLPLLSWRFDRRQIFLIATTPLVIIGFSMFLGTDNANARYGACFLLTSSLFAVGPIANSQVSANVVTDTARSSAIGLNVMAGNIGGLISTWSYLPHDGPDYHIGNGLNLAVTCTIFLVTIATLLWMKWDNKRREARHVEEELAGMSEQEIRDLDWKHPAFRWKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9D6</accession>
    <name>G0S9D6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pectate lyase</fullName>
            <ecNumber evidence="10">4.2.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0045470</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Pectinolytic enzyme consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins. Favors pectate, the anion, over pectin, the methyl ester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan to give oligosaccharides with 4-deoxy-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the polysaccharide lyase 3 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.2" evidence="10"/>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694932.1">
        <property type="nucleotide sequence ID" value="XM_006694869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9D6"/>
    <dbReference type="STRING" id="759272.G0S9D6"/>
    <dbReference type="GeneID" id="18258585"/>
    <dbReference type="KEGG" id="cthr:CTHT_0045470"/>
    <dbReference type="eggNOG" id="ENOG502QU39">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044863_2_0_1"/>
    <dbReference type="OMA" id="TLANICC"/>
    <dbReference type="OrthoDB" id="441042at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
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    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGS20047.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="353" mass="37215" checksum="F3F190F47D52F7B0" modified="2011-10-19" version="1">MHKLALLSLLPAVLACLDPSKNACASFMNANKATASAFCATFTRSLVTTTQGLPVWATNCSNKPSLLSKKCSCYFTGNTAPPTIVKATTAAEAPTIKTMTGLKATTTNKATTLQTSTVRVTAAPLEVTTALPKSSGAVSTSAAITVKAGQTFDGGMKNYDRWPRVCQEQKETGEADAMFVLEDGATLQNVIIGPNQAEGVHCKGRCNIINVWWQDVCEDAITLKQSSGTSNIIGGGAFKASDKIVQFNGFGTVNIRNFYAKDYGKVARSCGNCKTNGKGSRHIVLENIKAVDGGVLCGINTNYGDTCTIKSSCQKKNKTCDRFTGNNSGKEPNKIGSGADGQYCKVSSFVTSC</sequence>
</entry>
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        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
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        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
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            <end position="67"/>
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            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
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            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
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</entry>
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                <person name="Sarges P."/>
                <person name="Flemming D."/>
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                <person name="Kunze R."/>
                <person name="Devos D.P."/>
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            <dbReference type="PubMed" id="21784248"/>
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        </source>
    </reference>
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    </dbReference>
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        </location>
    </feature>
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        </location>
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        <location>
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    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
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            <begin position="595"/>
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        </location>
    </feature>
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        <location>
            <begin position="653"/>
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        </location>
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    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="729"/>
        </location>
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    </feature>
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            <end position="788"/>
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        </location>
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        <location>
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            <end position="854"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="962"/>
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        </location>
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            <begin position="978"/>
            <end position="987"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGS20161.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1008" mass="108681" checksum="7F2BCE72D53C794F" modified="2011-10-19" version="1">MMSRFRLKRAKDDLAAPRRSEESETTRNFLRKKDKKHQEEIPKKEFDLANALPSDDNFRTSLLMPSLSARFSMLREQDDPNTKIGKASDDSVLFPKRQSRLADFGFGGGASTGLSDIAEVESIRASSQAARDSTVSDDATNYTGSILNRGRPGEGNVLFGGRQKIYKIPAGSTSGLGGRALYEDDVSLSAFQRWRREERERLYAEQNGLNNTSSTDDAEEETEQSRSESPVSYNRKRETSTTTSSGSAARNSTAASSITSQPASTAPTTAVSTPAGERVVTRTRKLYETVNQDSTEPAPGLSRLESLTRQRPFARDASNSETADQSKPTGIKVQTDKSNVGGLPPLSPPISESGEHSLPSLLSKDAKVTATSLFQKSSAQTYDESQYVQRLQMLQQTKESSTQRQRTESNATTSSRPAESKSGITSPRPSLQQERLPPTPVAEIESTPSTGLSLNGLAMLPELQLERPSDKDHPAFRQPSLPTPSTASTNGKALSPALKPTISVETSKDPEPIDSPTLGPASGLSGLVLRHLRSESVESAVTGFSADLDSRLNLSSNLHSSLTSNTATASSNDSRSNAWSSAGSSREKEWTASYYSVGSDSSGEKRLGETQRKSDVVSSDLPDRSGNNIVTDEEQDEFATQLADARRRVREKLTSYVESDSSRAASPMPGSDSPNLAPQPSSNPLGILKPKSSRGSLIDRGRNMVTGPSKPFKILGIGGTTSNPPSSNKLGEEFPPLETMKEETVKEDAVHESESESKEDDANTHPGLRAFRQARRELQKRKELEMLARHQISQTQGGVNGEQGSKQRTPSRERRPPLVSYRGPTDEYGCNGSRTSGERGRSGSETSEGRSSSRPPLFSPDYRRSPADAKTSPMMPSHPFTRTGPSPVTSPLLERQRSNNNLHNAYGNGVPLSPAGTRSRQTSASAGQSPALGSGTFPAPVGKPPQYPPPQPPQQSGGYENGGTRSRSNSRSGGGAPQVPPPVPPINPRRRTEVSKTRPPFEVPGGMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0SA55</accession>
    <name>G0SA55_CHATD</name>
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        <submittedName>
            <fullName evidence="3">Putative sequence-specific DNA binding protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="4">
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Sordariomycetes</taxon>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
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                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EGS19627.1"/>
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    <dbReference type="STRING" id="759272.G0SA55"/>
    <dbReference type="GeneID" id="18258144"/>
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    <dbReference type="eggNOG" id="ENOG502SQYS">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059772_0_0_1"/>
    <dbReference type="OMA" id="FMTQPAY"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052635">
        <property type="entry name" value="Sec_Metab_Biosynth_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607:SF1">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607">
        <property type="entry name" value="XANTHOCILLIN BIOSYNTHESIS CLUSTER TRANSCRIPTION FACTOR XANC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS19627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="294" mass="32565" checksum="AD6791E92ADB1D0E" modified="2011-10-19" version="1">MYTMAQPHPFAYTAQPAHPPPPPPPTKQYPPTSSAFSSSAGPDEDWTKISDLAERRRIQNRIAQRNYRKKLKKRLEDLERRAGTSDGASSASGNDKTSSPAKKRTQASKTRTLLAPVKAAVPAPYTPPIRPEEEYLFQPTSYDQRDRSHSPPMFTYSTYPPPPEDMMMSASYGAIPAYRHIQPAEPYPDYLSPPPVPMVLPPMTHYTEAVKRDPSYPATTAAEESYPYMGYTSYIPGVDMGPAGHPSPYEQMPHTPPLSHSYDHSTACSESGSYDYPTTPLSMPGSPGMVQQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0SA74</accession>
    <name>G0SA74_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0041250</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694531.1">
        <property type="nucleotide sequence ID" value="XM_006694468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SA74"/>
    <dbReference type="STRING" id="759272.G0SA74"/>
    <dbReference type="GeneID" id="18258163"/>
    <dbReference type="KEGG" id="cthr:CTHT_0041250"/>
    <dbReference type="eggNOG" id="KOG0804">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009969_0_0_1"/>
    <dbReference type="OMA" id="SIECIDM"/>
    <dbReference type="OrthoDB" id="273556at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16457">
        <property type="entry name" value="RING-H2_BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12717">
        <property type="entry name" value="RRM_ETP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011422">
        <property type="entry name" value="BRAP2/ETP1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034931">
        <property type="entry name" value="ETP1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047243">
        <property type="entry name" value="RING-H2_BRAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007:SF7">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07576">
        <property type="entry name" value="BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="396"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="UBP-type" evidence="8">
        <location>
            <begin position="429"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="31"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="164"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="539"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="692"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="726"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="612"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="190"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="545"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="750"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS19646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="765" mass="85419" checksum="84D377707FA33BC6" modified="2011-10-19" version="1">MPYYYHLKFELYTTPDPTASQAEATILRNENNNIWNPEPGASVFDDLPSHPRSRDREQQESTPAKWPRSSSSREGARSAAAADDTAGSKIIDCGAHRGKSHNESGDEDGGRGRNIVRLSERQYRARLERSPPPRVERGIGPHTAVRDWRFGRVRIESFDLVVNHHHNNNNNNNNKKMAASSGKKDGATGQQQQQQQQQQQQQQQQEVQPAASLGPNLGGMGQATKARYVPLEGKNTEAGWGIVHLYREGDETSALRELPDGGDGKDASSGEDGTILCVPAVPSYMSPSDFLGFVGEKWRGDVSHYRMVMTSRMSRYMVLMKFRDAKRARQFRKEFDGKPFDSVETEICHVTFIKSITVETPNRKERKQSAGNGPTPVNSLKPFPPPTPDLIELPTCAVCLERMDDTTGLMTILCQHVFHCTCLQTWKGSGCPVCRATNPKPIDADPDDPYSARPFGQGVANICNQCNCTDDLWICLICGNVGCGRYNGGHAKEHWKLTAHSFSLELQTQHVWDYAGDKWVHRLIRDKGDGKIVELPRNATTIQPNNNNNNNNNNNNNQQNTNNEEYVPRSKLDSIGLEYTHLLTSQLESQRIYFEEMVNKAADKAAKAAAAAEAASAQAADALNQLATLREEHRVLREETVPSLEKELAREKQKSAKSADLARELSKALREEREVSAGLMKRIEHLQKEMEEKGKEMEKLRSENEELKEMNHDLTMFISGQEKLKEMEREGLVGEGELESGVVGGQGEGGEQEEGQGEEEMIGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAJ8</accession>
    <name>G0SAJ8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Carbonic anhydrase</fullName>
            <ecNumber evidence="2 10">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 10">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0042540</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="2 10"/>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694655.1">
        <property type="nucleotide sequence ID" value="XM_006694592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAJ8"/>
    <dbReference type="STRING" id="759272.G0SAJ8"/>
    <dbReference type="GeneID" id="18258292"/>
    <dbReference type="KEGG" id="cthr:CTHT_0042540"/>
    <dbReference type="eggNOG" id="KOG1578">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053879_3_1_1"/>
    <dbReference type="OMA" id="CGGIWAS"/>
    <dbReference type="OrthoDB" id="10248475at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071244">
        <property type="term" value="P:cellular response to carbon dioxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00883">
        <property type="entry name" value="beta_CA_cladeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1050.10:FF:000001">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002:SF76">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS19770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="234" mass="25142" checksum="4A02AF0F402B1F4C" modified="2011-10-19" version="1">MLAHEDSFLYALSSNNAWASYKAHQNPEFFHKLASGQAPEILWLGCSDSRCPETTILGLQPGDVFVHRNIANIVSPTDINTSAVIDYAVGHLKVKHIVLCGHTNCGGAMAALSDKRVGGVLDTWLLPLKTVRLAHLEELNAIEDLKARAARIAELNVEAGIKVLMCNPVVQEAIKERGMQVHGCIFDLASGKIRDLGIGTGGKVVLGAHHDEVVRGKHAQLVFTNGNAAMAVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0SB57</accession>
    <name>G0SB57_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="15">DNA repair and recombination protein RAD54-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0048980</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695259.1">
        <property type="nucleotide sequence ID" value="XM_006695196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SB57"/>
    <dbReference type="STRING" id="759272.G0SB57"/>
    <dbReference type="GeneID" id="18258936"/>
    <dbReference type="KEGG" id="cthr:CTHT_0048980"/>
    <dbReference type="eggNOG" id="KOG0390">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_10_2_1"/>
    <dbReference type="OMA" id="YTEHERM"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016817">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000010">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000332">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013967">
        <property type="entry name" value="Rad54_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08658">
        <property type="entry name" value="Rad54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="266"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="599"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="19"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="71"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS19437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="838" mass="94158" checksum="4012CABF4D3A27C9" modified="2011-10-19" version="1">MLADALLPAQRRVLALSHVNKSSSTSISHFEQTGPVSTTDAAPAATTHPNKENLVPKSRFPTQQAIERLHKPFKCPGAARPTLASDRPARKRRKVDYSGADGDADGNGDKPYTNADRLALPTREANKFPVFQVKDKEQVFRKAFSVPLINKSSYNPNRPPPSLGLRRGTVFVAKPLHDPCGEFAIVLYDPTIDDKPKDAPPPEEKEPEKKPEGPSMHKSLAEILGIKKQPVNERPRVPVVIDPKLAKVLRPHQIEGVKFMYRCVTGMIDPKANGCIMADEMGLGKTLQCITLLWTLLKQSPEAGKPTIEKAIVACPSSLVRNWANELVKWLGKDAINPFTIDGKASKEELTRQLHQWAIASGRSVTRPVIIVSYETLRLNVEALKGTPIGLMLCDEGHRLKNGDSQTFNALNSLNVSRRVILSGTPIQNDLSEYFSLISFANPDLLGSRAEFRKRFELPILRGRDADASEAERKRGDECLAELLSIVNKFIIRRTNDLLSKYLPVKYEHVVFCNLAPFQADLYNYFITSPDIQALLRGKGSQPLKAIGILKKLCNHPDLLDLPGDLPGCEQYFPEDFVPKDARGRDRDVKSWYSGKMIVLDRMLARIRAETNDKIVLISNYTQTLDLFERLCRSRGYGCLRLDGTMNVNKRQRLVDKFNDPNGDEFVFLLSSKAGGCGLNLIGANRLVLFDPDWNPAADQQALARVWRDGQKKDCFVYRFIATGTIEEKIFQRQSHKQSLSYCVVDSAEDVERHFSLDALRELFQYRPDTRSDTHDTFKCKRCKPDGKQFIKAPAMLYGDTSTWNHFVNEGLKNIEDHLLKQECGEPIVSAVFQYISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0SB98</accession>
    <name>G0SB98_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0049450</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695300.1">
        <property type="nucleotide sequence ID" value="XM_006695237.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0SB98"/>
    <dbReference type="GeneID" id="18258983"/>
    <dbReference type="KEGG" id="cthr:CTHT_0049450"/>
    <dbReference type="eggNOG" id="ENOG502SDAK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_226904_0_0_1"/>
    <dbReference type="OrthoDB" id="4590117at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="696"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="807"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="908"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="941"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1232"/>
            <end position="1755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1956"/>
            <end position="1994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2122"/>
            <end position="2154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2169"/>
            <end position="2243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2255"/>
            <end position="2294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2379"/>
            <end position="2406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="696"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="763"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="949"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1104"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1232"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1242"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1316"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1377"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1464"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1529"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1551"/>
            <end position="1562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1563"/>
            <end position="1577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1596"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1638"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1677"/>
            <end position="1696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1736"/>
            <end position="1755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2169"/>
            <end position="2182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="2788" mass="311042" checksum="3984F926FDF84561" modified="2011-10-19" version="1">MTNPTRYPSHLFEYVWPCGHHENVSIEEAPGMTLVRGQLTLPVAKQPEDFTEEERIGIPGRRKCCQCWATCSLFKRLDACEECEHLFNGCSTCMIVDSSGCREIATVEGRVVGEFDQTPEFWRCNECENLNSFGNEGPFNGFIAPKFADYLDETRCQNCQARFSEDHWVISPFWIYLGTWNGRVVAKGGPWYWSLEWHRNFAPADHSKENCYSTRKNGRKRRENPCIAKEELSKPHVEKKSFVIPTLVVQTDDNVSLPPLSSGLTPYAVDDHDRPGPKERLGPPSFEGHMLTIDNQTSNSAVFTIADYQDEDPEGQSIYGQEKDRLQIPEDDHQTVDIGSYYDAPSVYDQQSEERDCKEGDGSGEEWFVDHTQYTVVHNTYAVLATDAAAPFNPPGMTHDMLWDERDEDDDVPFSRKTNCEESAEKSEAEIEATLPEGQGQELNPAAILEEEFFDAQLGEKDADECLEEINPDGCGTERNIHEEQFNEEVERDMEQDEGLTGDPGDMFDDGEGEEEIVLENEGFINNDQIADYNPGENACNGNPAEEGVIELEPLYEMQSDDPIGETLPEGEKNLLEGEESPDVEVEPLMNELAEQIEELLQPELAEDELLEHEDVDRGVDSAQVEEQDLSENGELMEDGLLLEEEVFDEGSPGERGILDEELPREEEIFGEVPTGQGEFVGQEVIEEEGEVIDDAPLEENEGVGEELPQDEQVLDAASPEEGEIVDEEAPREEQVPGDDNFDGEEIIGEEVSQERGLTGEEFPQEDFLEEGVPEEGSPREVEYLDENDVPADIFPDDGFAEERKMREEPLLEEEQIVDRDLPEEGNVTNMDEIWDRNMGHLAARPEEGIIQAEPALVEQDGLEPYKPLEDDAVVDNTSSPQNETWLECKPLPDTRVLEEDVFTLCEPNMEGEGSNGCDPPVDNETHREGELMGRLDDEFIAEDEIASDEERAHHDEAPLEGGTSHVDEAISEGESSFPVDARAGPQGDVPPKLEESTQEVASPANEASPNALTAPGFEEDVELEGESAAKDSPEEVCPTNRAEQSAEDEGKPKPEASLPGDNDINEAGPSYEDEAPNENEGIQGRESPVVTDPEFDNFYTEFSEGRGSEGEFPHSQRRGAEPNEEYKTDDLIDGHTEEETGGVVDFEQARADSLQTADEQFEKAENCDDQSLPSDDAVRIDDLAQQDLPSCDEDTSIDSMPGDFELFVEEPGSLDRWPEQRKRMVKEQFKCIQPIEKEEPPTDDPPAEEVADVEQKPHPSMDADFDDPVAENPPFNQSLILSEGPNLCWPDQGSPIPEERPNQLEGSDGLALADHGSEGFFYKHAEGEEAFDDEPELMCPSDDGASGRVGRREEASLDESYEEEANARMESPSQGLREDPPDEHSSSCDGYVPPSPTGVAETALEAPDVGEVGICEEIAPDNVPLEENFDRESHLNNPLNESGNEYLPYDEIAGSGDKLPPLLKDRPREWCLRRQSEQQSKEPLLMERFEEGSTTSEEYHDGDSDHGPLELGLLADERSNWEPESSLDNDRGSEERPVTPQSLTPQVPANEDESRLEDEPFEDNHLDDRQPTDFEKNFFNGRRHSTFGENDEQSGSENSLSKLSVNELDSAQYSYPEDSQLHQDQQNWIGQKRGRFNTKTADSPTDPHTYQGLFHPHPGVRVSEMQFDTQSPSGRSFDHDDQSDVDHEGENRQDVQAEDDASDAGGDTLPEFPTPQHCRLSRDNQIPSPAPLSTKEPRLYHPRYERAHDKYYDPDDIRSDLPETPCHHDVWPDAAVPYPRHQPHVEEQPKPRHNNEVKDNRYSWLLPLMAIATLGWGMGNLEQQYRVGVRKEPRCSIRALVSELLGGKKRKGNVNTVLSCVQMDETIARETKAQTQKVRTCLSGSRQGLSNGLLLRNDDKRRRGFWSILPGRKKVKQSDLEAQTHPLIGEQLAPNNETPQYLSPVNHTPTWDQSHGFPNEPLGNGRTKRDPVGVVSSQEEATDGTCFDRSRRRKKAEQGGFLARLFGCPRKSRDPIDDLGSAEDKSIVEQFPDVEIDNKTSGADRRGFFARLFGWKSRVQNSDEPLMKNDGCNERTTGNSDLLNRECESHPKKGFFARLFYLRRTSRRTPVSEDIELGNIASSHSDLPRPGRVKTGSPQLVQRKDSRQSTIATLVDEYNAEQRRRQLLQEESLGKHKDKNTSAKSSRGKRTVKGKAQEDKRRSKIKGAQVLENNLPKPKPARRETGKRVSSPGTEAESGDNAANKYREAFHGSIIVRTPNAGGKDTCSTVPRDAKAKTQDQTQPYDPPERDTATVSNQYQAFKAMLHIVAATSSTFRRVLPGLVPSYRASNRHVASSSLRPGGGSSHTNSMADLPPRFLTDLEDSLLTPSQVSFISRSSSRQDVEVASTNGSTRRWDDPPEQEPVSPTDFVQSIVIRFIMRISRAPLATVFAAEITHVTFTPLDTHITTVVQKSSLQKLITPAGPMTLATFHADSGARLPNPVIAYRNWGDDQVSVNGAPAFMPLSAAGASLIVACAFYMIEPHMERTGLGRLPPLCPWVEVFDLTEGKRERLVKWAEAPIRAPLAWCGDGRYLAGVSVRDPRRVVVTSISFRAGASGKRKDLGTGKIEFMFSRHDDEVLHLAWLPIGAKGDGRWMAAGTKALVTVGKDGFVRITDALTGKTLKKLEVGARSPPSMLQVSPAGDMVVTVWGRDVILWYLDENRVHRHSLNDTRLTEGWPLCISPDCRYLACQTEDGFDICDLETGKFRGEYARRDLPQVTAAAFDNSGTRIVVATLSGSVEFFRLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBG5</accession>
    <name>G0SBG5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MHYT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0050190</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695367.1">
        <property type="nucleotide sequence ID" value="XM_006695304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBG5"/>
    <dbReference type="STRING" id="759272.G0SBG5"/>
    <dbReference type="GeneID" id="18259057"/>
    <dbReference type="KEGG" id="cthr:CTHT_0050190"/>
    <dbReference type="eggNOG" id="ENOG502R57D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008375_1_0_1"/>
    <dbReference type="OMA" id="HQEFGHI"/>
    <dbReference type="OrthoDB" id="264015at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005330">
        <property type="entry name" value="MHYT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35152">
        <property type="entry name" value="DOMAIN SIGNALLING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35152:SF1">
        <property type="entry name" value="DOMAIN SIGNALLING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03707">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50924">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="MHYT" evidence="3">
        <location>
            <begin position="19"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="829"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="839"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS19545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="916" mass="100555" checksum="BB52832B6DD9967E" modified="2011-10-19" version="1">MAADADLLTRLGQVVPVTFEPALLVLSYIISLVGAASTLELIHRRTSRRGYYNNLLLFGAAVTMGGVAIWSMHYIGNRATILANGDPRLQIAYSAGVTVASFFVPIVVLLVAFFVVTGAKGNTANVSWWRVSTSGILSGGAICGMHYLGNASISNYRLGYATSNVVGSVVIAAAASTIALALFFVFKSSWTNSWWKRLSCAVVLAGAVSGMHWCAVMGTNYTLIHLDSRSDLKSRNTTVIVTAVLSFSACMIIAGLAIYSARVRKGYANRAQRITLAAAVFDDQKRILVTPDGLLPSEVTGHERFSTTHPLFHWIFQASRNWGAISTLVDKMVLHLANLPHYGRNVRTAIELVDKEGHIIENYETIFCELFCVAAAALARQMNERLANVGMLWDEILTTGGHVLNDSGSSVSSSHNVRRDENTKKERRDHLDLLEKGEAQPEMLKHGHLMFLVRRVDNAQAEHLAAAGYLFAEPRQVAHIIGDRMQIRVKDFELKLRSMERYARGSMLAPGVHLGLFAVRTQFHQAGFDVLVRREARNLLPSMELPLDRLEQHHIDFLRSFHGVSMAAALHRLDRVSVADPRGTSFAAILRDAIRNLKTSVQDAVFNSAKLVPKIVQVPCIPLSSDSRPATCSMIVFSIMIPIHVRVEAPAYEFIPLQFFKVQQMVYKNCPHKAAFVRSMHRTISPLLNMTSTVDISSQSKSLFSRLKDFLLFGSWQGKDSAIHTAYNRLRRRKSRGHDTTLLSPSREHVALTSCNQSAVSLPLYNRTTSDDQGVSGLANVRADLKNPPEISVTELIDPIFPTWPLPPPSKASFGGIMISQEVTVDVEVANNGGPNGDKSSDNDSDVGRKKSIRALPSAANAPIPVPFDQAIEMCDVSAVLGIGASTVQVAKEDDDVIRTFVDDLFSTCLDTPKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBI5</accession>
    <name>G0SBI5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Telomerase reverse transcriptase</fullName>
            <ecNumber evidence="2 13">2.7.7.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Telomerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CTHT_0053700</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Chromosome</location>
            <location evidence="13">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the reverse transcriptase family. Telomerase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="2 13"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695706.1">
        <property type="nucleotide sequence ID" value="XM_006695643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBI5"/>
    <dbReference type="STRING" id="759272.G0SBI5"/>
    <dbReference type="GeneID" id="18259408"/>
    <dbReference type="KEGG" id="cthr:CTHT_0053700"/>
    <dbReference type="eggNOG" id="KOG1005">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001996_0_1_1"/>
    <dbReference type="OMA" id="FDTIPQE"/>
    <dbReference type="OrthoDB" id="289721at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000333">
        <property type="term" value="C:telomerase catalytic core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003720">
        <property type="term" value="F:telomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01648">
        <property type="entry name" value="TERT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.70:FF:000004">
        <property type="entry name" value="Telomerase reverse transcriptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021891">
        <property type="entry name" value="Telomerase_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003545">
        <property type="entry name" value="Telomerase_RT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066:SF0">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12009">
        <property type="entry name" value="Telomerase_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01365">
        <property type="entry name" value="TELOMERASERT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00975">
        <property type="entry name" value="Telomerase_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13 16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="9 13" id="KW-0779">Telomere</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="15">
        <location>
            <begin position="671"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGS18761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1125" mass="126881" checksum="024AF6C290AAE8BF" modified="2011-10-19" version="1">MVGGNDVLSRKRSRSTVSENNQQGQDAPPRYVKRVKHTVVPLSTTVKHDLLAQYYTETVTLRQYFLLRLPKTSRLRRRKISSIGRVGPGADRTPTEEERLLGDYLDSTIVARRYSSGETDEKADLRWKQWVAFSQKGSESCTTLSDGLKGSIYTQAEIVDFVIWLLFSRETASWPKHLLCDGFRKQTGPGMQANPAAAAGTTIPGVIRVYPNEHVDALKSSPWPQLLMLLGKEGERIMIDLLVDCAIFQPVKAGRGNLYQLCGVPVHELEALSKAARDVVRDTKLKPNLSSKANASANTSGLGPKNAELRPSEICFVRSRMLYARAALNARGLVHFGLRHIHVLNRFPYRDGEDGDESAVHVMMYIFPRQFGLHNVFTSPVDRSQTTQRFQDYTLREEEIAKKFPPVVVPKSDGSSAAKKSTRHVHIPKRLRGDALRLVRRLQVLHKRCAYTELLQYYCPLPIRGNGQKEEAVQVVQSRSVSSSLRSSLKPAKGREKSKTSGPAIVENLEYSTLTDLATPISSVSAFCQAVISKVIPKDFWGTGPVQEHNQACFLKKVHHFIHLRRFESMCLHEVMQGMKVHEIEWLAPPGLRGQKSSQSDTRKRTEIFYEFLYYLFDSFLIPLIRSNFYVTESSTDKYRLFFFRHDVWRYVAEPAMAALKTKMFEEVKTEDALRILEARQLGFSQVRLLPKQTSMRPIMNLRRRTAIRGKQRVLGPSINSILGPVNSVLKLEKALNPSRLGASMFSVGDIYQRIKAFKSRLGPGPHNNLFFAKIDVQAAFDTIPQDAIIALLNQIPQHVQYALLKHVEIAMSDATGPKSVARPYKRWHITALAAAAATERNGGGVRAQPSFPDRVEQSLALKRRDTVFVDSAVRRTLKARDILALAAEHIAQNLVRIGKKYYRQKEGIPQGSVLSSMLCSWFYADLERRRLGFLLESEDCLLMRLIDDFLLITTDRGKAERFVEVMTAGVPEYGVTVNPKKSLVNFDTVVGGEPVPRPEGRDGLQEPAIFNSLTVDFSRSPGWNFKRKVINAFKIQSHLMFFDTSLNPRTTVLSNIYSAFMETATKMWAYARCMAAAGKKPARGIITETIKTLIDVAFVLLTSRARRERYPGYVCSVKKGEVSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBM5</accession>
    <name>G0SBM5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0054110</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695746.1">
        <property type="nucleotide sequence ID" value="XM_006695683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBM5"/>
    <dbReference type="STRING" id="759272.G0SBM5"/>
    <dbReference type="GeneID" id="18259449"/>
    <dbReference type="KEGG" id="cthr:CTHT_0054110"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
    <dbReference type="OMA" id="GLMQDWP"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000003">
        <property type="entry name" value="Long-chain-fatty-acid--CoA ligase FadD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="24"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="7">
        <location>
            <begin position="452"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS18801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="555" mass="61593" checksum="D8C94F1C03E4D989" modified="2011-10-19" version="1">MPYPSTFPPLDIPNDIDLWTLLFDKQGDFPPSKEILTCFETGRSYTWETLRRKCVEFGEGLQEQWGWKKGDVLAFYTPNSIDTPILTLGALWAGGVVSPANPLYTADELAFQLSNSSAKALVTQPAYLQTALIAAKKAGLPPNHIILLGPQNGQVSSKHPHFTTIRGSNKSPHIRPPINPATDLAFLVYSSGTTGLPKGVCLTHRNMVANLLQASYVEGIQYRSRGGPDGRGDKQLGILPFFHIYGLTCGVLMSIYEGWQLIVLERFDLHKALQAIEKYRITFAYIPPPVVLAFSKHPDVEKYDLSSLKVLHSGAAPLTRELTEAVWNRLKVPVKQGFGLSETSAVVCCQTVDEWAKFMGSVGKIMPNMEAKIVDEHGKEVPEGEAGELWLKGPNVFPGYFKNPERTKEAFSPDGFFKTGDIFRRDKHGNYYCVDRVKELIKYNGYPVPPAELEGVLLGHADVADACVVGIEDRTRATEVPRAYVVLRAEVTLKNEAEKAQELTEWVAARVAPHKRLRGGVRFVKQVPKSPSGKILRRVVRDWAKKEGRAEGSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBT0</accession>
    <name>G0SBT0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Inner kinetochore subunit AME1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0054670</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695801.1">
        <property type="nucleotide sequence ID" value="XM_006695738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBT0"/>
    <dbReference type="GeneID" id="18259505"/>
    <dbReference type="KEGG" id="cthr:CTHT_0054670"/>
    <dbReference type="eggNOG" id="ENOG502SGUR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019416_0_0_1"/>
    <dbReference type="OMA" id="SVMRIKG"/>
    <dbReference type="OrthoDB" id="5377952at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048743">
        <property type="entry name" value="AME1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20994">
        <property type="entry name" value="CENPU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inner kinetochore subunit AME1" evidence="3">
        <location>
            <begin position="615"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="246"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="688"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="766"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="264"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="323"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="414"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="499"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="512"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="549"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="581"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="594"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS18856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="818" mass="90228" checksum="DDB60392B80374B1" modified="2011-10-19" version="1">MATREERMRDRMRGAGRHNVGEIDFGFVIPVAEDPPIDDDIDDDDDDDNDDDDDDNVQPSSPTARRASNQQQQQSLRPIPNTSAKRKHFDSDRDVIPTLRSSPPPPSVAPSTAALDTAVPVHYQQQTSPQDEEMPDVSPQEPSPYDQSMPDAPPLSAPHQPLRSPRTHGTLSSVISRTKRLSFDPSSPVRGPGPEEYEEMVTESPADAPGSGQRRRLRLAAAGQRTTPVVGSSALLHRMLADVDRADAEAERSGQLGLETSSPIERRVATRKSEVMRRSRSRSMASGESLSAGTERRSPRLNASTAAGSEMDVNGEEGQHEEVGEEMEEGEEGEEGEEEVVEEEVEGEEVEGEDNEPGLEESDEEKELGEPEGAPDEAIEAGAEADLGATEVQTSSPPAARERESALRSQEALVEGEQEQEEAQEIDNEEEAAQRLGRKRPRRTSPAGSPELELELQEESPAVKRRRRKGELTDPAQQQEPARRTKKRARPAAEPQPPTASFRTSPRSQPKSQLRPSPARSSPSLSPQPEPEPQTKAKPRTQPAAKPPGKPKTKRKPRPKQPRKTGGDGDEEDAPEDKGSVQITVQRFTNNDIPHAKDSRDERGEVELEPIPFANASGVNAIDVLSKLCEELIEAYLGKLEEKLQGTGNDEAGRAARREHKTMYRALEAFAEVLRTRLLEHTIAVDTLHSLRKRLRAAQKKRLALREQILRVRAEREQVALRMDAVRMRHEAEREKALRHISLSTAMHDIDMAVEQGRAAPELSASEQKQAELANLELLISRVADQACSRSDGGGALKQIKEFNAFLERAAAVLERRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBY1</accession>
    <name>G0SBY1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0055200</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695852.1">
        <property type="nucleotide sequence ID" value="XM_006695789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBY1"/>
    <dbReference type="GeneID" id="18259558"/>
    <dbReference type="KEGG" id="cthr:CTHT_0055200"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_1_1"/>
    <dbReference type="OMA" id="LICFGMF"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="362"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="66"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS18907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="462" mass="49513" checksum="3692084C336D131B" modified="2011-10-19" version="1">MDKDPEPAFASESDRTEVDVSIQLEEQKNTAVTANLSEYPEPASTSQQPPVPTPDDPPDGGLQAWLQVLGSTAILVSTWGVINTFGVFQAHYETSLLSSHTSSQISWIGSAQGALLFFVGVIAGPLYDAGYFRHLLITGQALTVLGQFMTSLCTTYWQVMLAQGVAMGCGMGLTFLPSAAILGQYFRRHRALALGLSSVGSPVAGTVFPVVFSKVLSKSGFGWATRAIAFILLGVSTIPVAFMRTRVPPTKAGRKRDWSYFIDNTAFMDWPYVLFVAGGLFAFLALYVPFFYIQLYATSRGVSGESFAPYLVTLLNVGSIPGRVIPTAMADRWGSLNLAIVCAAGSTVMVFCWLGIRGLGGAVVYALFYGAFSGGVVSLTPSVLVSLCPDMGRVGARMGMSFVVSGVAILVGTPIAGAILGNDRDPRWLGTILYSAFGLLVATLFYVSARILVYRRKQTWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBZ9</accession>
    <name>G0SBZ9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0055380</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695870.1">
        <property type="nucleotide sequence ID" value="XM_006695807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBZ9"/>
    <dbReference type="STRING" id="759272.G0SBZ9"/>
    <dbReference type="GeneID" id="18259576"/>
    <dbReference type="KEGG" id="cthr:CTHT_0055380"/>
    <dbReference type="eggNOG" id="KOG2056">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040577_0_1_1"/>
    <dbReference type="OMA" id="WRQIYKG"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16992">
        <property type="entry name" value="ENTH_Ent3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000006">
        <property type="entry name" value="Clathrin interactor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF45">
        <property type="entry name" value="CLATHRIN INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="2">
        <location>
            <begin position="27"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="349"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="415"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="474"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS18925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="506" mass="53089" checksum="EE09BEF6DCD221C0" modified="2011-10-19" version="1">MDLTSLKNTVANLTLYDIKAGVRKVQNAVMNYTEMEAKVREATNNEPWGASSTQMQEIADGTFNYQTLNEIMPMIYRRFTEKSAEEWRQIYKALQLLEYLIKHGSERVVDDARAHITLLKMLRQFHYIDHNGKDQGVNVRHRAKELVELLSDVDRIRAERKKARANKGKFTAIEGGSGFGSSSRYGGFGSDSYRGGSSSSYGGYAGGVYGDGGGFGGQTDEWRGSQSRADKFEEYNEFDESERPAASSSSSRATREAAAGKRPAEPKKEPEEDLFSFDEPAVPAASAAAPAQSSSSALAVLGSTADDDEFDDFQSAAPATQSAFTSSISPQTTTASSFASPLAAPKPVSASQQASLSGLAALTSISPPPSSTATPSANFSAFSSPLSASNLSSPVQTKPTGFQPSTPNYFSPVQTAAAAQKQSTASSGAGSKPGATAGGDAFGALWSQASAGLKKNTPSGPGPSMGQLAKEKSSASIWGAPAPSSAASQPSTNNKPLGNGPDDLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCG9</accession>
    <name>G0SCG9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphotransferase</fullName>
            <ecNumber evidence="11">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0057190</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16126"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="11"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696040.1">
        <property type="nucleotide sequence ID" value="XM_006695977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCG9"/>
    <dbReference type="STRING" id="759272.G0SCG9"/>
    <dbReference type="GeneID" id="18259757"/>
    <dbReference type="KEGG" id="cthr:CTHT_0057190"/>
    <dbReference type="eggNOG" id="KOG1369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014393_5_2_1"/>
    <dbReference type="OMA" id="ADCVQQF"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000092">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000004">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019807">
        <property type="entry name" value="Hexokinase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF16">
        <property type="entry name" value="HEXOKINASE TYPE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00378">
        <property type="entry name" value="HEXOKINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 11 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="13">
        <location>
            <begin position="29"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="14">
        <location>
            <begin position="230"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS19095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="494" mass="54524" checksum="09CF034FB509C35D" modified="2011-10-19" version="1">MAGDDPKTPPSEKGSGSDADVPKDLAKEIKYIEELFTVDTAKLKQITDHFVKELEKGLSVEGGSIPMNPTWVMGFPTGHETGTFLALDMGGTNLRVCQVTLTDQQSEFDIIQSKYRIPPPLKTGTAEELFEYIADCLLQFIQTHHDDLSQIGRMPLGFTFSYPATQNYIDEGILQRWTKGFDIEGVEGKNVVPMFEAALARRGVPIRLAALINDTTGTLIASAYTDPKMKIGCIFGTGCNAAYMEDCGSIPKLAHLNLPPETPMAINCEWGAFDNEHKVLPRTPYDITIDEDSPRPGQQAFEKMIAGLYLGEIFRLTLVDLHDNHDRRVFVGQDITKLRKPYTLDTSFLSAIEEDSDENLSDIAGLFQNKLNITPNKAERILIKRLAELIGTRAARLSACGVAAICKKKGYKECHVGADGSVFNKYPHFKERGAQALREILDWGEKKDPKEEDPIEILAAEDGSGVGAALIAALTLERVQKGNLHGILHPENYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCI2</accession>
    <name>G0SCI2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0057320</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I LYR family. SDHAF1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696053.1">
        <property type="nucleotide sequence ID" value="XM_006695990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCI2"/>
    <dbReference type="STRING" id="759272.G0SCI2"/>
    <dbReference type="GeneID" id="18259770"/>
    <dbReference type="KEGG" id="cthr:CTHT_0057320"/>
    <dbReference type="eggNOG" id="KOG4620">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_474062_0_0_1"/>
    <dbReference type="OrthoDB" id="273010at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20268">
        <property type="entry name" value="Complex1_LYR_SDHAF1_LYRM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045295">
        <property type="entry name" value="Complex1_LYR_SDHAF1_LYRM8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675:SF1">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="6">
        <location>
            <begin position="9"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="134"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="257"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="389"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="447"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="392"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="452"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="466"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="484"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS19108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="575" mass="63983" checksum="73113A9F99DA6B0E" modified="2011-10-19" version="1">MRRLSGLQKEVLSLYRQCLRECRKKPEATRQNFKVFARREFEKNLTIDKRDFTAIEFLIRKGRRQLEMYSSPGVKDIKFLQHRLKFRAVTPTVNDSTPNLSPTQTSVDEGFFEAAKDCIDELCVSHKHQMRQSQSPRTKVHFSDLPASTTGGTIDSARRVPGSPNRSPPRLVKGNPVARERCCRPGASFVRKQGKTESCRRGLAVLQSRVGMWVANRKGKIVVRQITNDDPFTSSKNSANKPIRQIKGFQLASYSNRGVQTTEDETLTGQDPEPSLRGTAPSSPYTTLSFRAGQRRTVPIRCLPSSIRRALAFPAKAGFVPPMRPLPVTHGNLRLLPDWGQVAKNNDEECGGYNHNKDQPESMSPGAAKDAVVTLALINKLDFPVRWDHSDNAPSHTKQPSNTSLFPSAASGARNHEAAPKQIHGPPTNWASASPFQRLRRAVALRRDRIADGSLPNLPNSPTSSRKISPKTQPSAAPSPLKENYSQPSQQLHQRSSTPVEQSQRGSMPPPTDDKADSDEEINDQDVLRGLRIVCAASADAEFDAMFSSKTGLRLRRFLADLKSLEELSELELKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCP5</accession>
    <name>G0SCP5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0057960</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696116.1">
        <property type="nucleotide sequence ID" value="XM_006696053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCP5"/>
    <dbReference type="STRING" id="759272.G0SCP5"/>
    <dbReference type="GeneID" id="18259834"/>
    <dbReference type="KEGG" id="cthr:CTHT_0057960"/>
    <dbReference type="eggNOG" id="KOG2273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007739_1_1_1"/>
    <dbReference type="OMA" id="MGWLEGI"/>
    <dbReference type="OrthoDB" id="71672at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06869">
        <property type="entry name" value="PX_UP2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047168">
        <property type="entry name" value="LEC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024554">
        <property type="entry name" value="LEC1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024555">
        <property type="entry name" value="PX-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN YPR097W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185:SF1">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN YPR097W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12825">
        <property type="entry name" value="DUF3818"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12828">
        <property type="entry name" value="PXB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="211"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="845"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="888"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="888"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="925"/>
            <end position="939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS19171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="957" mass="109464" checksum="6730C2EABD588932" modified="2011-10-19" version="1">MAAPDPAPTQVNGASKISEPGQPQSQKQPLRNGASPGVEQQNLLLTGKQEHYLKRELISEQVKWEISELNSPTALRRFGAPFKSDVGEVSPLDSELPILRYIFVHHIREFPFLDKAREKEFWQDKLQVFLESFANKNISSSEDRLEETKRRKLANKAKKLVELMMVSGIPTASGFEERIRFSEIEIVDANPTETGVLTTLPEGNYLNGWDVNVAGVRMISERRKLRHRKHAEFILRVKRKNGAEYHIGRRYGDFARLHKRLHTELPGKILPSLPHKNKSNMTALNMGVSVDGNNSDTESVWSVSTQLRSRHSANGSIHSTQSARWSSTAHRLSIKDQSSDGLSPRSSVDTRNGRSKTPSLRRPETPQAQEPVILWRESQRVSLRAFLRSLLQNSQIANTKAIEDFLTAEPITLTDEDREDIARRKLLDQRRVEEQKRFYEIARKRAAELDVYMEQFRQDIVERNGLTMLFKEIREKETIQDLSLQYQKFAEWLRIEVAATIYHLFLAEDNSPELFAQAKKIHSLIPYTLMKNVIRVANPAAVMSSILDIFLAQPFGTRSLMQRIFALTLHDGIRGFQRSIDILAEKIGDPIFVSKLKAYTDAEEQVKEAIRQEATGDGVDIIVAILRSELLGPPLESAQLEQLCNAYVAFNNAVENVDADLRQGAELFSYLKQLMKLYMRQRDKAMMLSLIEEPVTLQLFRDLFTIFYEPLVRVYKSANVYNSVTDFAQFVDDLIQVVERCRDQDASADPNQTVQAFIDLCQRHEHNFYKFVHEVHTHDNGLFTQLMGWIEGILEFLRKGPKNGALDMNALFEEAVRSGLIDKDKAIAEIDQLIAWQEARKRWHHNKTRQKMAAEGGPPPDGASDAVMPGLTAFRSADFGLDQDDLAEMGYDEDDSDDEEQAEEEDELDPIEAERKRRARRQDRLRRNAGEPQKPEVSEVHKLKANFLTMLRRVLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCS4</accession>
    <name>G0SCS4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0058250</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696145.1">
        <property type="nucleotide sequence ID" value="XM_006696082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCS4"/>
    <dbReference type="STRING" id="759272.G0SCS4"/>
    <dbReference type="GeneID" id="18259863"/>
    <dbReference type="KEGG" id="cthr:CTHT_0058250"/>
    <dbReference type="eggNOG" id="ENOG502S5YD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013856_1_0_1"/>
    <dbReference type="OMA" id="KYGVENR"/>
    <dbReference type="OrthoDB" id="2587563at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2670">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042065">
        <property type="entry name" value="E3_ELL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="464"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="603"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="731" mass="78057" checksum="298B6021119D0C00" modified="2011-10-19" version="1">MVLEVPDAGLLLESPANAGVALPLQAFAITLSDSIIEDIITCVQNGGSLELSLGSAPKLHFDGRDVRIPKTPDPAGYDLFRSTADNPSTATRLPYPAASLFKVPKLQKAKAKAAKTARTISKKEVAIKETQVRPSAVSSNAVPKPPQSKLEDDIANLESSYAKLEADKRENATLIRGRMLNPKAAKGKTGKNLLEPQAAASPRSLPPSPALSGIGSPSLAPAISSVQERAKQQRFPIIHELAVQPLTWRELKEKWDAAGVDGTEEDFSAAVNKVATLNPENKWELGKMHWKELDVFEYPYDSEKSRQKAINNAVRQYDRMRLASSDPLWQKLLPKSERGKGICLSKLQAAIAKGPAVSGPKLKPDASSNSGGDSEKDDASSATKKAKGGEPMSRSSSQASTGKKKLSPSEAQAKRLLSTSKKPGATKSTPKVSPNKTSKGAGVKGGRILSKEFVTDSSSDDEAASSTSISKSSVVAASLGKPAEQAVDKSKLSKTKEGITLKPKAVLPSRSVLKDKEKSDEKAKDTIRTQSAVKSAKPPAKRTRDADDDDSSSSGTPLSKRVKSVAKPLSTVAPPAKSRTSSDTASAIRAAGAAVPPRPKNTSPAKSSPLASSPPTNASDLDQDRASFFGEREPDHGTPSTVSNNTDGNGAASDKKRPTDDYSSPKPKRPRLSADIIEKAAKFKQFYARYEQLHHELAGLENPDPSKVTDLLDMHDRLSRLKREIYAEVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCT4</accession>
    <name>G0SCT4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0058350</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase g subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696155.1">
        <property type="nucleotide sequence ID" value="XM_006696092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCT4"/>
    <dbReference type="STRING" id="759272.G0SCT4"/>
    <dbReference type="GeneID" id="18259873"/>
    <dbReference type="KEGG" id="cthr:CTHT_0058350"/>
    <dbReference type="eggNOG" id="KOG4103">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083674_0_0_1"/>
    <dbReference type="OMA" id="NMTPPNL"/>
    <dbReference type="OrthoDB" id="437at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006808">
        <property type="entry name" value="ATP_synth_F0_gsu_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12386">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04718">
        <property type="entry name" value="ATP-synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS19210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="202" mass="21392" checksum="0049F0863E6865F7" modified="2011-10-19" version="1">MSSFALVMRRSGLAMGRRMVRFESTAPNAAQKAAESAKESASKASSSASDLASKATQGLSRVTSAAGPALAGAAKGLGAALTKLGGRSARLVAFVERQTPLVVYYSKVVVELGRLVAKGQNMSPPSLSTFQTYFQNVWKQLQNPSALLQKVNPQQLRNLSKAQVAAGGVVFAECLGFFTVGEMIGRFKLIGYHGEVHHDGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0SD28</accession>
    <name>G0SD28_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">(4-O-methyl)-D-glucuronate--lignin esterase</fullName>
            <ecNumber evidence="9">3.1.1.117</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0050590</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 4-O-methyl-alpha-D-glucuronosyl ester derivative + H2O = 4-O-methyl-alpha-D-glucuronate derivative + an alcohol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67452"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:171667"/>
            <dbReference type="ChEBI" id="CHEBI:171668"/>
            <dbReference type="EC" id="3.1.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:67453"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate esterase 15 (CE15) family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.117" evidence="9"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695403.1">
        <property type="nucleotide sequence ID" value="XM_006695340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SD28"/>
    <dbReference type="ESTHER" id="chatd-g0sd28">
        <property type="family name" value="Glucuronoyl_esterase"/>
    </dbReference>
    <dbReference type="GeneID" id="18259097"/>
    <dbReference type="KEGG" id="cthr:CTHT_0050590"/>
    <dbReference type="eggNOG" id="ENOG502QS8Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028869_1_1_1"/>
    <dbReference type="OMA" id="EQPWLGD"/>
    <dbReference type="OrthoDB" id="3781271at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054579">
        <property type="entry name" value="GCE-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22244">
        <property type="entry name" value="GCE_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409136" description="(4-O-methyl)-D-glucuronate--lignin esterase" evidence="11">
        <location>
            <begin position="22"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="12">
        <location>
            <begin position="22"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="64"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="64"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS18458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="481" mass="50714" checksum="4C0EDFC9CBFA1C08" modified="2011-10-19" version="1">MLSSVAASSLLFLLGAASVNAQRQSLWGQCGGIGWTGPTQCVDGAYCSQLNPWYYQCLPGGGPSTSSTPTTTSQTAQQPTTLSTSIVPTTTTSGPTTTSAAPGGGSTSCPAIPNGLGSPVSNQLNDPFTFHGGSKVTSKADWTCRQREISELLQRYELGTLPPKPQSVTASFSGSTLSITVTDNGKSISFSVSISNRPAGGGPHPAIITFGSFASIPIPSGVATISFNNDEIAQQQGGSSRGRGKFYDLYGSSHSAGALMAWAWGVSRIIDALELTQAQTNIDPTRIGVTGCSRNGKGAMVAGAFEPRIALTLPQESGAGGSGCWRIANWQKNRGENVQTSTQIVQENVWFSPNFNNYVNNVDALPFDHHLLAGLIAPRALYVMENVDMEWLGKVSTYGCMGIARKQWQALGSLDTFGYSQVGGNSHCSFPSSQQGSELNAFIGKFLLKNPNAGNTNIFRTTGNHNFNLDSWSPWAVPTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G0SD91</accession>
    <name>G0SD91_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein phosphatase 2C homolog 2</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0050940</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:47005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695437.1">
        <property type="nucleotide sequence ID" value="XM_006695374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SD91"/>
    <dbReference type="STRING" id="759272.G0SD91"/>
    <dbReference type="GeneID" id="18259132"/>
    <dbReference type="KEGG" id="cthr:CTHT_0050940"/>
    <dbReference type="eggNOG" id="KOG0698">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013173_4_3_1"/>
    <dbReference type="OMA" id="GPGIRNQ"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000016">
        <property type="entry name" value="Protein phosphatase 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF565">
        <property type="entry name" value="AT28366P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="13">
        <location>
            <begin position="23"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="386"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="394"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="410"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS18492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="437" mass="47684" checksum="37F654A1BC62087C" modified="2011-10-19" version="1">MGQTLSEPVVEKNSEHGGDERLLYGLSAMQGWRISMEDAHTAVLDLLKDDPKQAAQHPSKISFFGVFDGHGGDKVALYAGENIYRIVAKQESFKAGNYEQALKDGFLATDRAILNDPKYEEEVSGCTACVGLITDDKIYIANAGDSRSVLGVKGRAKPLSFDHKPQNEGEKARITAAGGFVDFGRVNGNLALSRAIGDFEFKKSADLAPEQQIVTAYPDVVVHDLSDDDEFLVIACDGIWDCQSSQAVIEFVRRGIAARQELDKICENLMDNCLASNSETGGVGCDNMTMIIVGFLRGRTKEEWYDEIARRVANGDGPCAPPEYAEFRGPGVHHNFDDSDNDYNDNKQSKAFGLAGYRGRIIFLGDGTEVLTDSDDTEMFDNAEEDKDLASQVSRSSSTTTIAATSSTTEEDKKEETKGESGSCDKKAEEQTQQKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDB1</accession>
    <name>G0SDB1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase epsilon subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA polymerase II subunit 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0051140</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase epsilon subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695457.1">
        <property type="nucleotide sequence ID" value="XM_006695394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDB1"/>
    <dbReference type="STRING" id="759272.G0SDB1"/>
    <dbReference type="GeneID" id="18259152"/>
    <dbReference type="KEGG" id="cthr:CTHT_0051140"/>
    <dbReference type="eggNOG" id="KOG3818">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010628_1_0_1"/>
    <dbReference type="OMA" id="PEDGAWF"/>
    <dbReference type="OrthoDB" id="10254730at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016266">
        <property type="entry name" value="POLE2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="9">
        <location>
            <begin position="481"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="181"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="660"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="675"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="693"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS18512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="831" mass="89669" checksum="D410525E49BFA77F" modified="2011-10-19" version="1">MMPIESPRKKSPRKPQHGSPSKRLKPPPPPFFAPKNTAPPLSAIPSSSPAFATPAHPLKPFQPPTPTKAAVLPIILPPATLRPLAFRTFTKKHSLTLTSSALQELATFIGRHCGSGWREEGLAEKVLEEVAKSWKNRNGGVIVDGTSPELKDILKTLEGNMSGGRIISGPRGLSRQNSLLEQADDSELSKTRMGLRPTPSLSREDSQAGMGVSSSMDVDDEPDDETLRDPRSWLKVINAFDQPRYTYNVAKKHFEKITTKPSLFPPPSHKTEAFRNRYNVIHQRLLRNEAFQTSAVTTSRLRRTNSAAMQSHKITPIANLLGCHGTNHMLLGMLSVLPTGNLAISDLTGSIALDLSHAVAIPEDSAWFTPGMIVLVDGVYEEDEEQVGKGLGGNSGVGGTIGGKFQGLFIGQPPCERRRVTLGVSGPDGGPDHTIGGGFGWIDFLGVGSERAVGSRMRKLEQRLLRQPSLADPEAPNRGRIVIVGELNLDQPRTLQALRKILSLYATDPEGSTPMTFVLTGNFTTHAVMARGGSGGSIEYKECFDALASTLADFPTLLTTATFVFVPGDNDGWVSAFTGGAAVPLPRKSVPELFTSRIRRAFASANSEAGLSGEGKGGEAVWATNPARLSLFGPNHEIVLFRDDISARLRRSSVRLKGKVPVQEETAADGDVTMSGANGSSTPQPAEDMDIDSQPPLMSSPPLQNLNLDGSGPSRPPQQRQQPPQTEPPLPYDILAARKLVKTILDQGYLSPFRPSIRPVHWDYTSALHLYPLPTALVLVDTTAPAFCVTYEGCNVMNPGPVLVPGRKGVARWVEYNVVSGKGGRVRECTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDC2</accession>
    <name>G0SDC2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0051260</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695468.1">
        <property type="nucleotide sequence ID" value="XM_006695405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDC2"/>
    <dbReference type="STRING" id="759272.G0SDC2"/>
    <dbReference type="GeneID" id="18259164"/>
    <dbReference type="KEGG" id="cthr:CTHT_0051260"/>
    <dbReference type="eggNOG" id="ENOG502QUK9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022730_3_0_1"/>
    <dbReference type="OMA" id="LEHSHVW"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF129">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="57"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS18523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="531" mass="57247" checksum="08DA08F5D59EF5B8" modified="2011-10-19" version="1">MAIRELTSEQAEGSESSLTMPPSGLPSANPTSSYWLSEPSPILLGHRTTEELPVETDVVVVGSGITGVFATLFLLEKNRLGGTIKGESLEKVVLLEAREVCSGATGRNGGHCQPLVYGSAPAVAAFELEVFKFMESLVKEENIPCDWVSLTGVHAFYSENMFELAAASVDQLQQTHPELAAQMEVVRPSSSSNQGDTLASLRVPTAKGAIVQKKAASLWPYKLVTQIVERLLAKYPPPTFNLQTNTPVTQLTRHESGNRWVAITPRGSITARHVLLATNGYTSHLLPAFADLIVPVRGQVGALLPPRPKVDAGEGSPAKLNHSYVFAADPEIETGATAPRDDYLVQRPMPTGELIYGGGRRFARSLGVGEWRDDELEPQVAEYLRKSLAPVLDLTPSSANSDEKTPTRELNASFEWTGVMGYSRDQHAWVGPVPESMGGGEGLWICAGYTGHGMPAAALSAREVVRQILTTNGAEIEGDAKDGVKLPREFMVSEKRIIEARTLPPLAQGWEATNFATLITSTGLLDQRKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDI1</accession>
    <name>G0SDI1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0051870</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695527.1">
        <property type="nucleotide sequence ID" value="XM_006695464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDI1"/>
    <dbReference type="STRING" id="759272.G0SDI1"/>
    <dbReference type="GeneID" id="18259225"/>
    <dbReference type="KEGG" id="cthr:CTHT_0051870"/>
    <dbReference type="eggNOG" id="KOG1691">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066963_3_0_1"/>
    <dbReference type="OMA" id="DVFEACF"/>
    <dbReference type="OrthoDB" id="759142at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409489" description="GOLD domain-containing protein" evidence="9">
        <location>
            <begin position="24"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="39"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS18582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="219" mass="25002" checksum="BF733655FF8E60E4" modified="2011-10-19" version="1">MARIPLLQRVCSILLLLAVGATALKFEIQAGSGHDAKSRRCIRNFVQKDQLVVVTAISDGYRGDGMQLSMHITDATGNEYGKPRDFAGEQRVVFTSHADAPFDVCFENVLTGSRYVDRPFRSIELDVDIGADAKDWAAIQAAEKLKPVETELRRIEELVAEIVNEMEYLRLREQKLRDTNESTNSRVKWFGFATTFLLIALWVWQIMYLRAYFRSKHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0SE81</accession>
    <name>G0SE81_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Tethering factor for nuclear proteasome STS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0062800</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 9">Binds the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the cut8/STS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696589.1">
        <property type="nucleotide sequence ID" value="XM_006696526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SE81"/>
    <dbReference type="STRING" id="759272.G0SE81"/>
    <dbReference type="GeneID" id="18260318"/>
    <dbReference type="KEGG" id="cthr:CTHT_0062800"/>
    <dbReference type="eggNOG" id="ENOG502RNK4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033658_0_0_1"/>
    <dbReference type="OMA" id="DMHKEVL"/>
    <dbReference type="OrthoDB" id="10061064at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071630">
        <property type="term" value="P:nuclear protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031144">
        <property type="term" value="P:proteasome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1590:FF:000001">
        <property type="entry name" value="Tethering factor for nuclear proteasome STS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1590">
        <property type="entry name" value="Tethering factor for nuclear proteasome Cut8/Sts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013868">
        <property type="entry name" value="Cut8/Sts1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038422">
        <property type="entry name" value="Cut8/Sts1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28032">
        <property type="entry name" value="FI02826P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28032:SF1">
        <property type="entry name" value="FI02826P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08559">
        <property type="entry name" value="Cut8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="51"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS18258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="346" mass="38495" checksum="827C7296B7D5B708" modified="2011-10-19" version="1">MNVLLSPQPPVLPHQREAARCPTPLSGMLASCSRSSSLDDEKDRRRALLHRARNSGRLFSDPSAASQIAMASRKRKVDDDQDEMSVSPLNSPPTISRQLASRPPKRTRPINDITGRPLPLHRLLETLNTTQLRQVLQKICERHPEISYEIVTTAERPSPEAALQVLSEYQEKLRAAFPFGESSSDYTYSRVRQALISLTDAISDFIPQFLPPIEQQVNHSFQFLDGATKIIHELPDWDNKQYNHHKDNAYDEISNAWALTITEAAKRGGGFILHSAGWDQCLAKHNQRSGGKLGLAMNALVTHVGWIGNNNGNVYQSSPAPLSDQSSILNQLLNGTYGSPVRVGPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEE3</accession>
    <name>G0SEE3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0063440</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIM50 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696651.1">
        <property type="nucleotide sequence ID" value="XM_006696588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEE3"/>
    <dbReference type="STRING" id="759272.G0SEE3"/>
    <dbReference type="GeneID" id="18260382"/>
    <dbReference type="KEGG" id="cthr:CTHT_0063440"/>
    <dbReference type="eggNOG" id="KOG1605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020262_7_0_1"/>
    <dbReference type="OMA" id="YLFHEDN"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FCP1 homology" evidence="3">
        <location>
            <begin position="372"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="294"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="301"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS18320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="532" mass="58164" checksum="4C8DC6AD36BA68B0" modified="2011-10-19" version="1">MNSLNIISARVSPPPSPGPSRSNSLTSISLAALNSDAEADETTGVVADALRSDDESELPQSPASPGLRSPRPAYLEADLVSEPDEFVLDDAISDVVSDGRPAEEEDLGEGEGRDMPVDEKTPLLSTRGGGGGGDYDGTHFGEAKVLSPVDDPAWMVYPKRFANAVMDSIRWLLSALTAPGVWLWMSLYDDTGKFAPLSQIRRVLFYREDDEPEPSLKKPGKVKPGGRKNRRLANTGSTSSSLSSESESDPDRRRQRRSASGKHPRTKSDAAGDDSPPTGQRSIRIKLQADEALRQRKANRKAQQSRSASSSNNAPDEATVADISAQLKSPTSPSGAGLTKYPKTPAPPRPLIPRRQPSYIKGPEPPLGPGGRPQHQKTLILDLDETLIHSMSKGGRMSSGHMVEVRLNTTYVGVGGQATIGPQHPILYYVHKRPHCDEFLRRVSKWYNLVVFTASVQEYADPVIDWLEADRKYFSARYYRQHYNAIPIQGWISDPTDSDLMYLIPFLEGMQYVSDVRALLGLRGGEDGTHIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEE6</accession>
    <name>G0SEE6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0063470</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2015" name="Nucleic Acids Res." volume="43" first="9994" last="10014">
            <title>Architecture of the eIF2B regulatory subcomplex and its implications for the regulation of guanine nucleotide exchange on eIF2.</title>
            <authorList>
                <person name="Kuhle B."/>
                <person name="Eulig N.K."/>
                <person name="Ficner R."/>
            </authorList>
            <dbReference type="PubMed" id="26384431"/>
            <dbReference type="DOI" id="10.1093/nar/gkv930"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) OF 1-92 AND 118-388</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696654.1">
        <property type="nucleotide sequence ID" value="XM_006696591.1"/>
    </dbReference>
    <dbReference type="PDB" id="4ZEM">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.55 A"/>
        <property type="chains" value="A/B=1-92, A/B=118-388"/>
    </dbReference>
    <dbReference type="PDB" id="5DBO">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="B/D=1-92, B/D=118-388"/>
    </dbReference>
    <dbReference type="PDBsum" id="4ZEM"/>
    <dbReference type="PDBsum" id="5DBO"/>
    <dbReference type="AlphaFoldDB" id="G0SEE6"/>
    <dbReference type="SMR" id="G0SEE6"/>
    <dbReference type="STRING" id="759272.G0SEE6"/>
    <dbReference type="GeneID" id="18260385"/>
    <dbReference type="KEGG" id="cthr:CTHT_0063470"/>
    <dbReference type="eggNOG" id="KOG1465">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016218_4_3_1"/>
    <dbReference type="OMA" id="RECIASQ"/>
    <dbReference type="OrthoDB" id="269919at2759"/>
    <dbReference type="EvolutionaryTrace" id="G0SEE6"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051855">
        <property type="entry name" value="eIF2B_beta_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="13 14" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS18323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="4ZEM"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="5DBO"/>
        </source>
    </evidence>
    <sequence length="388" mass="41865" checksum="1B9523160A07E16F" modified="2011-10-19" version="1">MAPSQASHTPSLATWTKSLRDQSLEASIESLIFLLKRRQVTGDECAGAIAQLLRQVVAKSKWHDVDQLLYRVQTAGARLARAAPHEPVIGNIPRPEPASSPTTSPSPARTLTSGLQVSKSMFNLLSVADPSESPVTGASTPISQAQQPFSVHALRSEVMDGIEEILDEINQADDQIASFAEIQIHPGDYVLAYQPSKTVERFLVKAASKRRFTVILASLNPPAPGEEEQPYAALRKKLNAAGVSTINLASNGLMAYIPRVNKVIFGAKAVYQNGGLLVDSGACIAAQAAHEYLKPVIALCGVYKFCPEDPSDEVSRGELGNPSSYVSYADGPELDSFEVENTTTDYIPPDLVDVYLTNLGPQTRHHLGGIYADHYKIEDIGFSLQVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEL3</accession>
    <name>G0SEL3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Malate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0064150</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696721.1">
        <property type="nucleotide sequence ID" value="XM_006696658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEL3"/>
    <dbReference type="GeneID" id="18260453"/>
    <dbReference type="KEGG" id="cthr:CTHT_0064150"/>
    <dbReference type="eggNOG" id="ENOG502S85Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067863_1_0_1"/>
    <dbReference type="OMA" id="LKFLGHH"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021851">
        <property type="entry name" value="DUF3455"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567:SF3">
        <property type="entry name" value="MALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567">
        <property type="entry name" value="MALATE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G13800)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11937">
        <property type="entry name" value="DUF3455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409505" description="Malate dehydrogenase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="25635" checksum="1C50F9DD2DED64CB" modified="2011-10-19" version="1">MVSVWKLFASFAVAGFAAPSCRPPATLTLPKVGGGTELPPPPPTLTLKKIALGHGIQNYTCESTTGEAKATGALAVLYDVTSLHPSATGRNTLSPIVWNKLPSTLLWTNPLPLNPLPTVHFGADPANPFPEPSSLRLHSLPEIKFLGHHFFDAQSTPTFDLKIANLKASVAKTGAVDAPRNADKGILGTGAVSWLELGDNGKGLSQGVSKVYRVITAGGVAQKCEVAGAGAQSVPYTTYYWFYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEN3</accession>
    <name>G0SEN3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0064360</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696741.1">
        <property type="nucleotide sequence ID" value="XM_006696678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEN3"/>
    <dbReference type="STRING" id="759272.G0SEN3"/>
    <dbReference type="GeneID" id="18260474"/>
    <dbReference type="KEGG" id="cthr:CTHT_0064360"/>
    <dbReference type="eggNOG" id="ENOG502SAXX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050718_0_0_1"/>
    <dbReference type="OMA" id="PFAQTAS"/>
    <dbReference type="OrthoDB" id="2402960at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="416" mass="45679" checksum="9BC0C48188973601" modified="2011-10-19" version="1">MDDQFGGRTDDDLFADDIEPVDEALAVPVVISDTPSPAPAVTPARDAQTNEQTEKQAAMAQEEKPAAPAKSLAHSRHNPRGRGGGAEKPPRSTNHSKHNNKSHKSTHNNNTDNGNSTTDSSTTPTPSSSTPKPKRSSTGQNTSSVSSSTRLTSGANPRPKLTEAELTARIEKMRLLAAEKERRFEQAQRDESEHQAAIAKSIEEDLKRRKAAEERRKREEEERKRLEEERERNRERKLRVLKERGGWTGESHDEPDRGFRSAAGGVKGYKGMGASRFAAESNDQEDGDSFGRGGMSGRGRGGRGRGGGRGGRTLFEAYPEREREREERRHWRDRGQTQCESAADQKMDQKDKNPELKPEDFPALPSTSGVPKKLEVTWPAKPSPGKATSMADIPLSPPVGKWDDEVAAAAEVYSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEN6</accession>
    <name>G0SEN6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0064390</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EGS18413.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006696681.1"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502RMXY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141170_0_0_1"/>
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    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409473" evidence="1">
        <location>
            <begin position="24"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="186" mass="20605" checksum="85841DAB2AF9C765" modified="2011-10-19" version="1">MLKSILNVVTLAAITLLHGITFAAPIAELVPVSAPGRIPSLNTTELELLPRQSGEGIHLMNCNPIMGGADPTRKWTWVSAVFYCPNDADCSRLNYSPDYNDVCIMKTSYTEGDFHRWEGGEQSCRFPTGVTFKWGIIPNAQAFRDYSHVGSGSNGYRDFRGYKDNKGNGANMPGLTHSCKKIYYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEW5</accession>
    <name>G0SEW5_CHATD</name>
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        <submittedName>
            <fullName evidence="10">Putative homeobox protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0059940</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
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        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
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            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
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        <text evidence="2">Belongs to the engrailed homeobox family.</text>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
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    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="74"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
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            <end position="135"/>
        </location>
    </feature>
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            <end position="315"/>
        </location>
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            <end position="448"/>
        </location>
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            <end position="715"/>
        </location>
    </feature>
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        <location>
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            <end position="152"/>
        </location>
    </feature>
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        <location>
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            <end position="179"/>
        </location>
    </feature>
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            <end position="196"/>
        </location>
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            <end position="222"/>
        </location>
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            <end position="252"/>
        </location>
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            <end position="272"/>
        </location>
    </feature>
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        <location>
            <begin position="273"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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            <end position="375"/>
        </location>
    </feature>
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            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="692"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010896"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="EGS17981.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="715" mass="76926" checksum="8D8A57500266A08D" modified="2011-10-19" version="1">MDMNYNSYLDPLGRRYAAAPALTMPPTYGPTQPVVHPPIPQYQVHPAYQPTYWTAAPYYAYQRGMYLPQGAILTKPTEPKPRLAKDEVELLESEFAKNPKPSSSVKRELAEQMGVEVPRINNWFQNRRAKEKQLRKTAEFEAQQAREREKAAAEAAAKAAAEKQNQEAAGDSKDEDKQQDSSSTSNAPQSEANTTIKAEEPAVECKAGDQVSPSSSQPASAPTNQYSFKSTSDNFSQVKVENSVSPVSQSQLAGELTPRPMTNGSYSESQNHSAMQQQMTLQQSQTTAYDYQPADRGSVDGFPPPVLENVTSQHSDTAISEAAAFSPFPEPDYFSTPTVSQFQSDMISAVAPSNPDNQFLRHQPSTESLAQSEGVSPSAIPDSPSTVSSLRFKSPPPPADIAGRRKIRRPAPLGLSALRVGSGPKTGAPDAQRRDLASPLRRISSATGPLCGRVQKTSYVGSGPRSPFAMDRTKEVLLQSIQSTQAGFMPSLNGTISPLSPEGFPGQSLTDSVVGATTASLSSTDDEKSTYPFTTLGTSTVIHSLPPLYNAGDVAVRSPPNTPGLPMSFTPANPTTNDPYFSASSSLDPTWKYMPTSQDDPLQTPGLVSHTSSELDFPPLQQQQLPGYVASQPQTPSFPPTTGAVDSVFPTTSLYTGNPSGVDYHPFPESTYPTDSSAKSSPVAPVRPMGSVTLQQPTKQFQFAQNVTPQDFGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0SF79</accession>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
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    <organism evidence="5">
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
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                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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    <dbReference type="STRING" id="759272.G0SF79"/>
    <dbReference type="GeneID" id="18260148"/>
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    <dbReference type="Proteomes" id="UP000008066">
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF14">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
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        <location>
            <begin position="60"/>
            <end position="103"/>
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        <location>
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            <end position="344"/>
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        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGS18095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="504" mass="55479" checksum="9904FFFC8BEC5535" modified="2011-10-19" version="1">MPPRRSHKKSRTGCRRCKTRKIKCDEVHPRCGNCVKHGVKCDFEYPEVLAELQAAQAASQSPSTPSAASGYASPAAGPSSARSTATPLCRPPPTPALSQTTPPGQRLLELRLMHHYTAMTCKTFTFTAPVTEDIWKITVPNLAFSGSQHLADAILAVAALHLRSMRPDDKEMVRASHAYMAASLSEYSAALTKGIDHTNAEALFLTAALIAFQSTATRVFSKDEPQVGSEESDKRGPSGCYTIPFSWFHSFQGVKAITAASWQYLRVSPVVTQVINSQAALQLDFRTGPETFFGHLLEGMEEELAAMASEYSSANTDSTNDQQPQHPPRKRRPPPPNSLPQLGAPLAFPATVSRRYIELLEERRPRALAILACFFALLKSLDSVWWLQGMARREVLGVVSLFNSDYFGPDAYRTWWPHLEWAMRIALWEPPPGSQPTPDSPPGGVVIPPEIWGADWYAEEQALARGQAQHGGYVRHIELLSQMSSALQSFPPIVDYIGMENPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G0SF88</accession>
    <name>G0SF88_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Endo-1,3(4)-beta-glucanase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0061190</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696435.1">
        <property type="nucleotide sequence ID" value="XM_006696372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SF88"/>
    <dbReference type="STRING" id="759272.G0SF88"/>
    <dbReference type="GeneID" id="18260157"/>
    <dbReference type="KEGG" id="cthr:CTHT_0061190"/>
    <dbReference type="eggNOG" id="ENOG502QUM3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016972_1_0_1"/>
    <dbReference type="OMA" id="IVNIDVC"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF42">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G02280)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS18104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="278" mass="30355" checksum="6C4B0EACB413486B" modified="2011-10-19" version="1">MGTEDTRQNSGTSFFEKFSYFHDYDPAGGFVHYNLTYATSDTVIIKVDTTVGPGSEPDASTGRFSVRLESKKHPNNWPMNGEIDILETANIQDPSSPDTSAIMALHTTEGCTMQSVQREMTGSAGQSDCHNATNYNTGCVVTTKDYSSIDGGNAAARAFNAAGGSGIVALEWREEGIRLWVFPREEGGLQRMIGSSMPDPSVWGRPIADFPSTKCDIGAHFRNQSIIVNIDLCGYMTEATWESSGCGPQSCVEFVANNPLAFQNAYWEFGEFRVYQAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFB6</accession>
    <name>G0SFB6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="3">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0061470</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase delta/II small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="3"/>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696463.1">
        <property type="nucleotide sequence ID" value="XM_006696400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFB6"/>
    <dbReference type="STRING" id="759272.G0SFB6"/>
    <dbReference type="GeneID" id="18260185"/>
    <dbReference type="KEGG" id="cthr:CTHT_0061470"/>
    <dbReference type="eggNOG" id="KOG2732">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021763_1_0_1"/>
    <dbReference type="OMA" id="HCILIGT"/>
    <dbReference type="OrthoDB" id="3763at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.430:FF:000002">
        <property type="entry name" value="DNA polymerase delta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.50:FF:000006">
        <property type="entry name" value="DNA polymerase delta subunit 2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040663">
        <property type="entry name" value="DNA_pol_D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024826">
        <property type="entry name" value="DNA_pol_delta/II_ssu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18018">
        <property type="entry name" value="DNA_pol_D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA polymerase delta subunit OB-fold" evidence="12">
        <location>
            <begin position="48"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="11">
        <location>
            <begin position="225"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="359"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="279"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS18132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="526" mass="58793" checksum="3A9E6C34AF3AD119" modified="2011-10-19" version="1">MVKLEEIADTTLLQKPSGDTQSPVERVESKYKPLYKFNLPRHRQYHQQYADIYFLRLTKLKPAVEAVAREAWEDTMIGGEIARRVERVLDVRQGQLCWMVGTVYMDMPLKPSVLEDISKDRWIGNPITTGHYFQDDGSGTTIMLEDDSGRIRLVGSRLQDFFLVTGCIIAVLGTENVNGEFEVIDLKFADLPPQPERWALTKPPSKGGRKNEDIEMADSKPSKKIAIVSGLEFSGYDTSHAMDLNLLLEFLLGDALTPSTQATELSQISRLIIAGNSMGDSTHNPSTTAYSRNPHVPPKPHVKKYGYDSSSFNPLPSQLLDQFLSTLLPTMPVTLLPGILDPATASYPQQPIHSAMFPRARTFGPTPKPPPPPPPPGKEAEAAQQEMQEEKEPGWFDAVTNPWEGEIEGWRFLGTGGQNLDDICKYIDSEDRLGMMEAMCRWRCTAPTAPDTLWAYPFQEDEPFTMLECPHVYFIGCQPQFGTRVIEGPQGQTVRLILVPSFASTREIVLVDAETLEVSTVKISTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFC8</accession>
    <name>G0SFC8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Helicase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0061590</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696475.1">
        <property type="nucleotide sequence ID" value="XM_006696412.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0SFC8"/>
    <dbReference type="GeneID" id="18260197"/>
    <dbReference type="KEGG" id="cthr:CTHT_0061590"/>
    <dbReference type="eggNOG" id="KOG0298">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001592_2_0_1"/>
    <dbReference type="OMA" id="KAVFFCA"/>
    <dbReference type="OrthoDB" id="5330228at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001870">
        <property type="entry name" value="SNF2 family helicase/ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052583">
        <property type="entry name" value="ATP-helicase/E3_Ub-Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059033">
        <property type="entry name" value="C144_05_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26021">
        <property type="entry name" value="Ferritin_C144_05"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="338"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="1088"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="1198"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1041"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS18144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1436" mass="161855" checksum="17A7326E836D2ABC" modified="2011-10-19" version="1">MPRAKPNQKGGSRPQSSSPKRENDDEITAFVEYLRAIPTEADERQGEPAARPAKRPRTSGPDAICVARQRLTIAAPASSGPSIYYPLERIDIGEVVSLKVRNTDPDDSLQGQWALYVSSRTKSRTRGFRASFPLDNDALSAEVRSALMVAETQGFNPGDEDCIWASVDVCVRQDNSSLQLHIFIQVNWNPRATIWGSKKAKSSQQQTLREMVLGTWYPDLHLTTVLGQALPSWSPQDFYEAACVPDKAALDAEVSSMEVPKLEANLYPFQRRAVQWMLRREGVHWYQDPETKQTGILPYNSPTTSELPISFVTSKDSDGNDIYLSPLFRTLAKDVRPFTAFQEFRGGILAEEMGLGKTLEVISLILLHQRPQSPVMVFDPFLGQQLLSTSATLIIAPTTLLDQWLSELKRHAPSLRILFYPGIRKLARLKDGNEISAKYLAEQDVVVTTYEVLRTEIWAAVDEPDRSMRNEKQLPDLRGLLLFLRYEPFASDTKLWNTLTTLDKPSFKKLFNSISMRHSKSMIRNEISIPAQKRYVITMPFTAVEEQHYQSLFEELAESCGLDVRGNPLRPDWDPEDPGVQNAMRVALDRLRQTVLHPEVGIRNRRALGQKSGPMRTVAEVLDAMLEQSDGSIRTDQRSLLSAKLTRGQILACQKKVDEALALWQEVLAKSTEMVAECGTQLEQEIQEAKKANANEYHQPSQADSEFDDRDEIVSPPVGEARRRLRYALEIQHRAVFFCANAYFTIKSDKERTDPGSEEFKRWEKLEVEGYEQAKQIRKEILHETQSKAKKLMGRLAHAAARKSFATIPEFKAINNKGIESYRIAMALEDLGVSLDAQASYLDDWREHVIQLLLKPLVDEEDSETTGEEYEQSTKLQDEILVYLQVLRTAIADRQAVLTGQKNFLVEHETNVAARLAKAGNGPYPEKLLELLKIRDTIKPPFQECDPLSSLRGLLSELRSLSAKLRHDAAMGSSRAAAEQAILSNLLKSTLNQQSEQMKAATAMEKELQQFMDTVNARIEFYRQLQEVSDMVADYKGPQEESALAAALENLERQEESLQTKLAATEAKHRYLLHLKEAEANSEEQRICIICQSPFTIGVLTICGHQFCKECMTLWFKEHRNCPVCKRHLTHSNLHDIVLKPQELKVHSESSNRDHEPSDQGHQLTNVSGIYKEFNAEKLAEIKNIDLDGPSFTTKVDTLVRHLLWLRESDPGAKSIVFSQYKEFLDVLGTAFRRYRIGYTSFDKARGITDFKEDPGTEVFLLHARAHASGLNLVNASHVFLCEPLLNTALELQAIARVDRIGQQHETTVWLYIVDGTVEESIYSLSVQRRMEHMAIRTLAGKGKELTSELSDTTLDEANALEMQQAHLSKLMGKDGISGETVDKDDLWTCLFGHLNKNKNSGIVGGSANPVNAATRRFLAAEAAERRIRGDQGDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFG8</accession>
    <name>G0SFG8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0070760</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697351.1">
        <property type="nucleotide sequence ID" value="XM_006697288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFG8"/>
    <dbReference type="STRING" id="759272.G0SFG8"/>
    <dbReference type="GeneID" id="18261114"/>
    <dbReference type="KEGG" id="cthr:CTHT_0070760"/>
    <dbReference type="eggNOG" id="KOG0802">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_489154_0_0_1"/>
    <dbReference type="OMA" id="QVHTRAT"/>
    <dbReference type="OrthoDB" id="1305878at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052256">
        <property type="entry name" value="E3_ubiquitin-ligase_CHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16079:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16079">
        <property type="entry name" value="UBIQUITIN LIGASE PROTEIN CHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="29"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="166"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="267"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="297"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="417"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="429"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="509"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS17733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="557" mass="62498" checksum="6415694A1D91E53D" modified="2011-10-19" version="1">MAEPSEQTTSQSISTAPAPVVSLETELTCSICTDLLHNPLTLLDCLHTFCGACLKEWFRFQADRIESLPGPPLPREPRSTHAPPAGKQYATPGTMLGCRRYWICFWACTLRRERAKRRKREMDRRYTRGERVMRRLKFEDRSEEEARRDEEERRLIDEVRAVSLREATERALQGSSSSPSGRRERPRDTRAENAAAAATGEQQRRQIEHQASLRSLISLEGGEMTPSDIEREIEEFARQIQEEGLLDGIDLDNIDLSTNDELSRKITEAYRRRQREKARRQREQRARSTSRAPTMGSERERGRERDPDRDREGERDQDRERERNRERDRSTAPPRSASRNRDPSARPTSRHSMAGHTSSHSRAPSVTSVDDRARYPPSASASASALLEVPDPTTVRRRRASSAGRSATIPPVQLEGRVPERARSETGTRDSSSTRGSDGRSSGSPTTTTAPASSGSRTSSFSSRTGAIPGDRLSVPGPLPSRDPSPETRHRHRQTPLILLPPPIPNPTPASASATSNFPPFVPERASDQSALFNLLPPIHPKRAALLLSEMQSPRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFI9</accession>
    <name>G0SFI9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0071000</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697372.1">
        <property type="nucleotide sequence ID" value="XM_006697309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFI9"/>
    <dbReference type="STRING" id="759272.G0SFI9"/>
    <dbReference type="GeneID" id="18261138"/>
    <dbReference type="KEGG" id="cthr:CTHT_0071000"/>
    <dbReference type="eggNOG" id="KOG0663">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="OMA" id="WVARATN"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000054">
        <property type="entry name" value="Cyclin-dependent kinase 11B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000211">
        <property type="entry name" value="Cyclin-dependent kinase G-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF107">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="137"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="430"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="463"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS17754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="500" mass="55933" checksum="DFC51277423B4A6A" modified="2011-10-19" version="1">MSARPKSRWADDEEDAALEAQRKREKEEKKRQKAAEKARKLAEQQQQQAARQPQQQSQSQSQSQQLEEKHHSTEEDDANGPPAKRRRLSPERESTATATTAPVIARGGVTVAVTNDDRKLLRFEAPPFGRSRSVEHYEKLNDIEEGAYGWVARAKESATGKVVALKRLKIDANDRSGFPVTGLREIQILKDCEHRNVVKLLEVVVGEGLDSVFLVLEFLEHDLKSILDSMPSPFLTSEIKTLLLQLASGVSYLHAHHILHRDLKTSNLLLSNRGLLKIADFGMARYVGDPPPQNLTTLVVTLWYRAPELLLGTPKYGREIDLWSVGCIFGELLTREPLLQGRNEVDQLTQIFSLCGLPTDESWPSFRRLPHARHLRLPPAPKGQTTFSLIRAKFPLLTTAGASLLASLLSLDPAKRPTAEEVLQHEFFKQDPKPKSEAMFPTFPSKAGQERRRRRETPNAPGRGQGMAEGGLDFGSVDWSGIFAGRDKEERGGGFSLRMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFM6</accession>
    <name>G0SFM6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Superoxide dismutase 1 copper chaperone</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Superoxide dismutase copper chaperone</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0071390</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CCS1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697409.1">
        <property type="nucleotide sequence ID" value="XM_006697346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFM6"/>
    <dbReference type="STRING" id="759272.G0SFM6"/>
    <dbReference type="GeneID" id="18261177"/>
    <dbReference type="KEGG" id="cthr:CTHT_0071390"/>
    <dbReference type="eggNOG" id="KOG4656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056632_0_0_1"/>
    <dbReference type="OMA" id="KNVWEER"/>
    <dbReference type="OrthoDB" id="666972at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
        <property type="term" value="P:superoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000038">
        <property type="entry name" value="Superoxide dismutase 1 copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="11">
        <location>
            <begin position="6"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS17791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="275" mass="29359" checksum="495746212B632AC4" modified="2011-10-19" version="1">MATTTPFQTLFAVPMTCDGCAKDITNALYKLPGILKVETNVKDQLVSIEGTAAPSAIVKAIQDTGRDAILRGSGTSNSAAVSILETYHHGADEQADSSAGAELTPNGIWVNKRLVRGLARMVQVSPTETLVDLTVRGVPPGTYRATIRQTGNLTDGVTSTGPVWSSLAPDQEVTNGDSQKQSTPRGFLGTVEVGPNGYGTVFLNKPFQVWEVIGRALVVSRQEEHGQEGLQNSEDTVVGVIARSAGVWDNDKTVCSCTGKTLWEERRDEVKKGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFR4</accession>
    <name>G0SFR4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0071830</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697447.1">
        <property type="nucleotide sequence ID" value="XM_006697384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFR4"/>
    <dbReference type="STRING" id="759272.G0SFR4"/>
    <dbReference type="GeneID" id="18261221"/>
    <dbReference type="KEGG" id="cthr:CTHT_0071830"/>
    <dbReference type="eggNOG" id="ENOG502SI3D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028820_0_2_1"/>
    <dbReference type="OMA" id="WDVWGNA"/>
    <dbReference type="OrthoDB" id="77201at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000428">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF16">
        <property type="entry name" value="GPI-ANCHORED CELL WALL BETA-1,3-ENDOGLUCANASE EGLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409144" evidence="9">
        <location>
            <begin position="19"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="343"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="343"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS17829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="394" mass="42358" checksum="C15BC2E4911E36DD" modified="2011-10-19" version="1">MRASALIAACLLASGVSAENYLGFNSGNTLPDRSAKFKKDFKAEFETAQNLENAPGKFNSVRLYTNIQAYSTDEPIEAFEAAIETKTKLLLGIWTSGTDSIENELSALKKAIKKYGKDFTDLVIGMSIGSEDLYRVSETGIKNKAGVGAGPQTLIKFINDYKKAIADTPLASVPIGHVDTWDAWTNSSNKAVIDALDWIGVDEYPYYENGKGNNIKNAGRLFDRAYAAVEAAAGGKPIWVTETGWPYTGPDWDEAVPSVENAQYYWQEVGCRKLFNKVPTFWYNLRDSNPDNEMKFAITKNLSTKPLFDLTCPTKFETPDYDPNESASATTPGATATGFTTVVSTATPTGSPASESGSNGSDSSAEENSGSMGKGLSMAAIGSLALVAGVFALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0SG30</accession>
    <name>G0SG30_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">N-acetyltransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0064840</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696787.1">
        <property type="nucleotide sequence ID" value="XM_006696724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SG30"/>
    <dbReference type="STRING" id="759272.G0SG30"/>
    <dbReference type="GeneID" id="18260522"/>
    <dbReference type="KEGG" id="cthr:CTHT_0064840"/>
    <dbReference type="eggNOG" id="KOG3216">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_41_2_1"/>
    <dbReference type="OMA" id="QSEWVRY"/>
    <dbReference type="OrthoDB" id="7305308at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000086">
        <property type="entry name" value="Acetyltransferase, GNAT family, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051016">
        <property type="entry name" value="Diverse_Substrate_AcTransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545">
        <property type="entry name" value="DIAMINE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545:SF29">
        <property type="entry name" value="GH14572P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="5"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS17169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="185" mass="20716" checksum="A4C50FDE4AE19F81" modified="2011-10-19" version="1">MSAAPIIRHAHREDVPAILELIRELADYEHELQSVEATEAKLLETIAFAPPDAPDLAVTGNIPTTEPTSPSRPARCLVLITPEGVTAGIALYFYNYSTWRARPGIYLEDLYVKQSERKKGYGKRLLVQLAKEVVAMKGGRLEWSVLKWNEPSIKFYEAVGARMMNEWVGMRVDGDALTRLASMLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0SG55</accession>
    <name>G0SG55_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphatidylglycerophosphatase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0065090</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696812.1">
        <property type="nucleotide sequence ID" value="XM_006696749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SG55"/>
    <dbReference type="STRING" id="759272.G0SG55"/>
    <dbReference type="GeneID" id="18260547"/>
    <dbReference type="KEGG" id="cthr:CTHT_0065090"/>
    <dbReference type="eggNOG" id="KOG2961">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056221_3_2_1"/>
    <dbReference type="OMA" id="WHEYTAK"/>
    <dbReference type="OrthoDB" id="198652at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008962">
        <property type="term" value="F:phosphatidylglycerophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027706">
        <property type="entry name" value="PGP_Pase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010021">
        <property type="entry name" value="PGPP1/Gep4"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01668">
        <property type="entry name" value="YqeG_hyp_ppase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF25">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROPHOSPHATASE GEP4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09419">
        <property type="entry name" value="PGP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS17194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="21242" checksum="BB9C8116BD17517E" modified="2011-10-19" version="1">MSLNLNLSASLNIFRLLAKPSLCLPHATVATFDDLPIPLNKAFSAREKSVDIRAIHRFEVLRAAYPGRCLLIVSNTAGATSYDRDGSLAAAVEKATGIHVLPHSVKKPGCGDEILAYFQQHPETGVTGPHQIAVVGDRLFTDMMLANMMGSWGIWVKDGVVPLQQKSIFARVERKLAPWLLSRGYASTDPSSPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>G0SG58</accession>
    <name>G0SG58_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0065120</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696815.1">
        <property type="nucleotide sequence ID" value="XM_006696752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SG58"/>
    <dbReference type="GeneID" id="18260550"/>
    <dbReference type="KEGG" id="cthr:CTHT_0065120"/>
    <dbReference type="HOGENOM" id="CLU_1299563_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="212" mass="23753" checksum="8FC41401DDCA908F" modified="2011-10-19" version="1">MPNQQRNGLPKNNSHSTSSSTGEEPFYNPWTQFYWALDWETKEEHNRRKAPDAENAASKKSTKGHKQRRSQSVLGLLSLEDPPRPTSRRLNTQCTSPGSQPIRQVSDPSRLLQEGGSKRQSRFHRFSRLFQPAMTRTSAAPPASIVDSDTAPLLQGQVADRMEAESKSDRSIRTIWGWLKRAVSKSSLRRREADGSRTIGEPSTGPNGRSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGR6</accession>
    <name>G0SGR6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enolase</fullName>
            <ecNumber evidence="3">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CTHT_0067300</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(2R)-2-phosphoglycerate = phosphoenolpyruvate + H2O</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Mg(2+) is required for catalysis and for stabilizing the dimer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="3"/>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697023.1">
        <property type="nucleotide sequence ID" value="XM_006696960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGR6"/>
    <dbReference type="STRING" id="759272.G0SGR6"/>
    <dbReference type="GeneID" id="18260768"/>
    <dbReference type="KEGG" id="cthr:CTHT_0067300"/>
    <dbReference type="eggNOG" id="KOG2670">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031223_0_0_1"/>
    <dbReference type="OMA" id="RCMMSHR"/>
    <dbReference type="OrthoDB" id="1739814at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.10:FF:000001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000002">
        <property type="entry name" value="Enolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902:SF1">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00178">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enolase N-terminal" evidence="15">
        <location>
            <begin position="3"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase C-terminal TIM barrel" evidence="14">
        <location>
            <begin position="143"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="374"/>
            <end position="377"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGS17405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="438" mass="47496" checksum="AD8394B0E273EA76" modified="2011-10-19" version="1">MPISKIHARYVYDSRGNPTVEVDVVTELGLHRAIVPSGASTGQHEACELRDGDKSKWGGKGVLQAVKNVNEIIGPALIEKNVDVKDQKAVDDILLELDGTPNKTKLGANAILGVSLAVAKAGAAEKGVPLYAHISDLAGTKKPYVLPVPFMNVLNGGSHAGGRLAFQEFMIVPSAAPTFSEAMRQGAEVYQKLKSLAKKRYGLSAGNVGDEGGVAPDIQTPQEALDLITEAIEEAGYTGQVKIALDVASSEFYKEDVKKYDLDFKNPESDPSKWLTYEELAALYAELCQKYPIVSIEDPFAEDDWEAWSYFYKTQDVQIVGDDLTVTNPLRIKKAIEQKACNALLLKVNQIGTLTEAIQAAKDSYADGWGVMVSHRSGETEDVTIADIVVGIRSGQIKTGAPCRSERLAKLNQILRIEEELGDNAVYAGENFRKAVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0SH19</accession>
    <name>G0SH19_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TeaA receptor TeaR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0068370</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697126.1">
        <property type="nucleotide sequence ID" value="XM_006697063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SH19"/>
    <dbReference type="STRING" id="759272.G0SH19"/>
    <dbReference type="GeneID" id="18260875"/>
    <dbReference type="KEGG" id="cthr:CTHT_0068370"/>
    <dbReference type="eggNOG" id="ENOG502S2RX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023414_1_0_1"/>
    <dbReference type="OMA" id="PINRPEG"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="501" mass="54944" checksum="A542303414EF3BE5" modified="2011-10-19" version="1">MYDGNARDFYYSSRTPLTAHNGNAVINFETSSRGYGADDKPHKDNSSAVDRASLDPNDGPSTDSREDFHDRRPREFYGDSDSDENSKWIHRDKLARIESEELQAAGIILPRPKDRTRSKSQNRPRRDPSQDKLNSSGRSIAGSEYTARSRKNSTATSTTETRTADPASIASWDLRRPEEILEEAEAQKAASSSSGKSSSRIPVAKSSHVPIPTEHIARDTVLTRKRDPSPTDEDSITYPKTRARSGSTGNAPSKTTNAGTTPQSNKRVDSQQKKSSATASPVNRKTKPVNGTAGRPKTRGGPNKDSTSSTRPSTRSGEREFSITNSKPMEGDPPWMVSAYAPDPRLPPDQQLLPTVAKRLQQEKWEREGKFGNIYDKDFRPLTDSGFPKPPEVTGNSSEKDKTDADENKQEEKVVQDQKAEDSSTSKDWPLKPETKSPTLPGKGSSYSTIPKISDNRPVTSPLASPLPPGPQSQAGKPVVRLPEPPEETKQKKGCGCCIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>G0SH24</accession>
    <name>G0SH24_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0068430</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-14 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697131.1">
        <property type="nucleotide sequence ID" value="XM_006697068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SH24"/>
    <dbReference type="STRING" id="759272.G0SH24"/>
    <dbReference type="GeneID" id="18260881"/>
    <dbReference type="KEGG" id="cthr:CTHT_0068430"/>
    <dbReference type="eggNOG" id="KOG0239">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001485_12_1_1"/>
    <dbReference type="OMA" id="MCRVRPP"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01366">
        <property type="entry name" value="KISc_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000065">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972:SF45">
        <property type="entry name" value="PROTEIN CLARET SEGREGATIONAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 10 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="14">
        <location>
            <begin position="622"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="203"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="268"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="371"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="205"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="224"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="306"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="713"/>
            <end position="720"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS17513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="974" mass="108544" checksum="32D0C95B22D81E5E" modified="2011-10-19" version="1">MAASPGAAPGGAAAAPSQSASAASEVAVPHQRQSDAGSSSTSVAPTKSANSKRTRRISAAAALTVRPARIQVPVPPPAPANPVTVYHRSPPDPTMAVLGGLPLAPAIFFGCLGEINRQIAQSSIHSLRPGTNTSPRRDPPRISPTLPPTSSAPGAVLLSSFLLVNYLLPRMRAALNMESSENPTFQSRLHPPTFRSGLLQEMSDSHTNARAHTSQIPTKLSQPEPKRKTLAERAGEHPKAQMSTATHGTGIPRLNSIKGQSIANLNANTHATAPSRPIHTKFSKSVGGGMRAAPQPPRAPTSMGFSRSTSTRSRANTRTSRPQTAVGYHDAEEEVIEISQHKGWDVDGRLSEFESQFEKMKEAFEGTMKDRKTLEDAIDLAKARTNDLEREKQRLLDQNTQLHNQLEAQRQEIYSLQQEKQSMLLEFEREQQRHKFDLEDKVRNHRHELDEVRRQFKAEVDQMNREHREALEALERQHRAQLADEQAQKARELTELRARLGAEQQDMNLELLRKEREIQELRSHIEALKSDLDREQALRTTLQQQVAEMSTTNLALEDRMRALRAKIEFLESDSKQQSDAFAQMENRLQEALRVAEEARQKLIKEETERRVLFNKYQELKGNIRVMCRVRPVLDPSEGEEAKISFPDTKTSTQIDVTGPEERSSLGTVTRKVIPFEFDRVFDPSVKNEEIFGEISQLVQSALDGYNVCIFCYGQTGSGKTYTMSSPDGMIPRATHMIYDTITKLREKSWSYTLEGSFVEVYNEELHDLLAENTNNGVPRKKLEIRHDEVRKQTTVLNCRTVALDSPEKVEAMLKQAQANRSVAATKANERSSRSHSVFILRMVGENSATGERCEGTLNLVDLAGSERLKHSQAEGDRMKETQSINKSLACLGDVIEALGKGSPHVPYRNSKLTHLLQYSLGGNSKTLMFVMVSPLEAHLKETITSLRFATKVHNTHIGTAKSTKKLKSVDRSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G0SH57</accession>
    <name>G0SH57_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 16">Elongator complex protein 3</fullName>
            <ecNumber evidence="16">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CTHT_0068790</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>uridine(34) in tRNA + acetyl-CoA + S-adenosyl-L-methionine + H2O = 5-(carboxymethyl)uridine(34) in tRNA + 5'-deoxyadenosine + L-methionine + CoA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:61020"/>
            <dbReference type="Rhea" id="RHEA-COMP:10407"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74882"/>
            <dbReference type="EC" id="2.3.1.311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:61021"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="16">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the ELP3 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="16"/>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697164.1">
        <property type="nucleotide sequence ID" value="XM_006697101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SH57"/>
    <dbReference type="STRING" id="759272.G0SH57"/>
    <dbReference type="GeneID" id="18260917"/>
    <dbReference type="KEGG" id="cthr:CTHT_0068790"/>
    <dbReference type="eggNOG" id="KOG2535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025983_2_1_1"/>
    <dbReference type="OMA" id="TFETRPD"/>
    <dbReference type="OrthoDB" id="10265243at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106261">
        <property type="term" value="F:tRNA uridine(34) acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000003">
        <property type="entry name" value="Elongator complex protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056591">
        <property type="entry name" value="ELP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01211">
        <property type="entry name" value="ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23613">
        <property type="entry name" value="ELP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005669">
        <property type="entry name" value="Hist_AcTrfase_ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="14 16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12 16" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 16" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 16" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5 16" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Radical SAM core" evidence="18">
        <location>
            <begin position="99"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="17">
        <location>
            <begin position="393"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR005669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGS17546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="554" mass="62906" checksum="9E85DE4B8A217082" modified="2011-10-19" version="1">MATATITTTKRSKKDVDLPPENERFLRCCADIANALIEDHEASKDPTRPKKDINLNTLRAKFAKKHKINNVPPLTAIIAAVPEHYKKYILPRLIAKPIRTSSGIAVVAVMCGPDSDFEYSTQSYTGYEPTSMRAIRARYDPFEQARGRVDQLKALGHSVDKVEYIIMGGTFMSLPEAYREEFIAQLHNALSGYSTSNVDEAVRAGEQSSIKCVGITIETRPDYCLQPHLSSMLRYGCTRLEIGVQSLYEDVARDTNRGHTVAAVAETFCLAKDAGFKVVSHMMPDLPNVGMERDLYQFQEYFENPAFRTDGLKIYPTLVIRGTGLYELWRTGRYRNYTPNGLIDLVARILALVPPWTRIYRVQRDIPMPLVTSGVENGNLRELALARMKDFGTTCRDVRTREVGVNEVKHKIRPNQIELVRRDYTANGGWETFLAYEDPKQDILIALLRLRKCSEKYTFRPELVGQPTSMIRELHVYGMAVPLHARDPKKFQHQGFGTLLMEEAERIAREEHGSIKISVISGVGVRSYYRKLGYWLDGPYMSKWLDGRPGPEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHH9</accession>
    <name>G0SHH9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0070080</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="476" last="476">
            <title>High-resolution structures of a thermophilic eukaryotic 80S ribosome reveal atomistic details of translocation.</title>
            <authorList>
                <person name="Kisonaite M."/>
                <person name="Wild K."/>
                <person name="Lapouge K."/>
                <person name="Ruppert T."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="35079002"/>
            <dbReference type="DOI" id="10.1038/s41467-022-27967-9"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.90 ANGSTROMS)</scope>
    </reference>
    <reference evidence="10 11" key="3">
        <citation type="journal article" date="2023" name="Nat. Struct. Mol. Biol." volume="30" first="670" last="677">
            <title>Structural inventory of cotranslational protein folding by the eukaryotic RAC complex.</title>
            <authorList>
                <person name="Kisonaite M."/>
                <person name="Wild K."/>
                <person name="Lapouge K."/>
                <person name="Gese G.V."/>
                <person name="Kellner N."/>
                <person name="Hurt E."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="37081320"/>
            <dbReference type="DOI" id="10.1038/s41594-023-00973-1"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.20 ANGSTROMS)</scope>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2024" name="Nat. Commun." volume="15" first="716" last="716">
            <title>Methionine aminopeptidase 2 and its autoproteolysis product have different binding sites on the ribosome.</title>
            <authorList>
                <person name="Klein M.A."/>
                <person name="Wild K."/>
                <person name="Kisonaite M."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="38267453"/>
            <dbReference type="DOI" id="10.1038/s41467-024-44862-7"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.10 ANGSTROMS)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697286.1">
        <property type="nucleotide sequence ID" value="XM_006697223.1"/>
    </dbReference>
    <dbReference type="PDB" id="7OLC">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="SM=1-144"/>
    </dbReference>
    <dbReference type="PDB" id="7OLD">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="SM=1-144"/>
    </dbReference>
    <dbReference type="PDB" id="7Z3N">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="SM=1-144"/>
    </dbReference>
    <dbReference type="PDB" id="7Z3O">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.30 A"/>
        <property type="chains" value="SM=1-144"/>
    </dbReference>
    <dbReference type="PDB" id="8OO0">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="SM=1-144"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHH9"/>
    <dbReference type="EMDB" id="EMD-12976"/>
    <dbReference type="EMDB" id="EMD-12977"/>
    <dbReference type="EMDB" id="EMD-14479"/>
    <dbReference type="EMDB" id="EMD-14480"/>
    <dbReference type="EMDB" id="EMD-17004"/>
    <dbReference type="STRING" id="759272.G0SHH9"/>
    <dbReference type="GeneID" id="18261046"/>
    <dbReference type="KEGG" id="cthr:CTHT_0070080"/>
    <dbReference type="eggNOG" id="KOG3406">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110343_0_0_1"/>
    <dbReference type="OMA" id="CAEHQIP"/>
    <dbReference type="OrthoDB" id="10249311at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000530">
        <property type="entry name" value="Ribosomal_eS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047860">
        <property type="entry name" value="Ribosomal_eS12_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11843">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00972">
        <property type="entry name" value="RIBSOMALS12E"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01189">
        <property type="entry name" value="RIBOSOMAL_S12E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8 9 10" id="KW-0002">3D-structure</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="5">
        <location>
            <begin position="28"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS17668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="7OLC"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="7OLD"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="7Z3N"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="7Z3O"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="8OO0"/>
        </source>
    </evidence>
    <sequence length="144" mass="15940" checksum="6F0D9330C7A0F744" modified="2011-10-19" version="1">MSDVEETTAPQEVEVSAEAGKGQMSVLDALKGVLKLSLMHDGLARGLREASKALDRRQAHMCVLNESCEEEAYKKLVIALCQEHKIPLIKVPDGKQLGEWAGLCVLDREGNARKVVNCSCVVVKDWGEESQERTVLLNYFQQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHU8</accession>
    <name>G0SHU8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0073440</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697600.1">
        <property type="nucleotide sequence ID" value="XM_006697537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHU8"/>
    <dbReference type="GeneID" id="18261382"/>
    <dbReference type="KEGG" id="cthr:CTHT_0073440"/>
    <dbReference type="HOGENOM" id="CLU_2468868_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="88" mass="9374" checksum="F67D042B705EABFF" modified="2011-10-19" version="1">MTTIPSNARRFPLRTLTLATWMVHGSPRRTSQKSAKAPRPKGESESRDVTDPDSPTDPVGATVGPFAALVAKQLAELAAAKQSETPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHV5</accession>
    <name>G0SHV5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Succinate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="8">1.2.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0073510</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>succinate semialdehyde + NAD(+) + H2O = succinate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13217"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 8">
            <text>succinate semialdehyde + NADP(+) + H2O = succinate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13213"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.16" evidence="8"/>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697607.1">
        <property type="nucleotide sequence ID" value="XM_006697544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHV5"/>
    <dbReference type="STRING" id="759272.G0SHV5"/>
    <dbReference type="GeneID" id="18261389"/>
    <dbReference type="KEGG" id="cthr:CTHT_0073510"/>
    <dbReference type="eggNOG" id="KOG2451">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_5_1_1"/>
    <dbReference type="OMA" id="IGELFCK"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="UniPathway" id="UPA00733"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036243">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000005">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010102">
        <property type="entry name" value="Succ_semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01780">
        <property type="entry name" value="SSADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF5">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="23"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS17025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="495" mass="53203" checksum="EC302A0D1214966D" modified="2011-10-19" version="1">MSVPKLRDPSLFKQGVAYVNGEWVPAKSGKTFDVHDPATGKFIGSCPEFDAQDTEKAIEAAAEAFESFRHLTGRQRSKLLRRWYELVMENADDLATLITWENGKPTADAKGEVVYAANFFEWFSEEAPRIYGDTIPSSVPGNRVFTIKEPVGVCGLITPWNFPAAMITRKVGPALAVGCTVVCKAPGETPFTPLALAELAHRAGIPKGVVNVITALDNTPEVGEVLTTHPTVRKVSFTGSTPVGKLLMKQCSGTLKKLSLELGGNAPFIVFDDADVDAAVAGAIASKFRSSGQTCVCANRIYVQRGIYDEFAEKFAAKVREFRVGNGFEAGVTHGPLIHHRAVEKVERHVHDAKEKGAKVVLGGHTLPDLGPNFFQPTVLTGMTPEMVMASEETFGPVAGLFPFDTEEEVVKMANSTPVGLAGYFFSRDVARVHRVAEHLEVGMVGVNTGLISDPAAPFGGVKESGFGREGSLYGIGEYQVTKMITVGGVGTLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHZ2</accession>
    <name>G0SHZ2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0073900</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697644.1">
        <property type="nucleotide sequence ID" value="XM_006697581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHZ2"/>
    <dbReference type="STRING" id="759272.G0SHZ2"/>
    <dbReference type="GeneID" id="18261428"/>
    <dbReference type="KEGG" id="cthr:CTHT_0073900"/>
    <dbReference type="eggNOG" id="KOG0068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_282276_0_0_1"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12169">
        <property type="entry name" value="PGDH_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050857">
        <property type="entry name" value="D-2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="5">
        <location>
            <begin position="130"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="489"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="603"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="668"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="875"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1015"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="530"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="603"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="689"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="707"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="875"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="896"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="908"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1039"/>
            <end position="1066"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS17062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1107" mass="120838" checksum="EF6141CC754E138B" modified="2011-10-19" version="1">MVPIKVAVLDDYQGISEPKFKALDPAQFEVTFFKDTLLPYNHPDTPDEVREQLVKRLEPFDVISTMRERTPFPEALINRLPNLKLLLTTGTRNLSLSLPTFQARGIPVAGAVDRQHAGSVGSVSTTEHCVAMILAAARNIAQDDLTVKNGGWQTVPAVSLKGKVFGTVGLGRLGAAVARIMSVGFGMKVIAWSENLNQEKADQKAREMGLPVEDTNGEKTFRAVSKEELFSTADVVSIHLVLSDRSRGCIKKRDLELMKKGAIFVNTSRGPLVVEEDLLEVLEQGRIRAAALDVFELEPLPANSRWRTTRWGEDGRSRVLLTPHMGYVEEATLDAWRNRDNSEVLSIVKPIDSFPLIPLTCIKKSPLFFGNFECLLFNKQGDWKCQSSENDSLVSRADPVTFSRNTGNNSSSSFTVGRSANSATPCIFGQSSNEGWDRLGSLKPGEIREPSAPAAHLFSFSASPIVSHPSSTAESNQLAIGPQAQRPLQSLTASVSSPQIAHRSQTSGGTLVIGSARRQAASTPRIIPNRVNTEAATPQLNQRRRNTNNSAGDFTSPQITNCSQTSSTTSSLVVTTFRATDTSQTSGNDRVQVSAAPLISNVQPSLSTSKSTGSTAALETSKHSQSSGSDSIQGGVTHRRSQNLNKSAAGSPATQATVRQSVVGLAPPQVTSLPDEVTQPTKAPALPKTNRQPMSLNKTAKAPATSGAPQAQQTLVNKENNGTATPQVNQLSPNNSNTWIGGFGTSQVDHRLQETNKAAGGSGAHQAIKSTAVKVEASNGESGLGRHLTQSLPNPHAAQEEARWQARKSALLGLSRICEFRGCIPQWETRSSNEGWFATVIVRSTAYMAGPYRKAEWAKIVAAERALNALGSRAFQAQKQAQRRGSTYRPSHGKPNNNLAANVQQNQKSSNPTGPSSQGNMNQSQKATHQTARPAQEQQTAHQIPHPPQQVPINQHARPAQHESPPHPTFPSSQHDNLADVQLPDYARNNPIALQAFFEGLALGARMADVIIRSSREDERSRHHERSRSRSPLQASRSDNIRRYRERTPRVSEPLRDTYRSPSESRSRRRRYRGSCLPQEFWDRYHPASSDGANGRWEHDRYPYYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G0SI30</accession>
    <name>G0SI30_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0074290</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697682.1">
        <property type="nucleotide sequence ID" value="XM_006697619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SI30"/>
    <dbReference type="GeneID" id="18261467"/>
    <dbReference type="KEGG" id="cthr:CTHT_0074290"/>
    <dbReference type="eggNOG" id="ENOG502S025">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_563949_0_0_1"/>
    <dbReference type="OMA" id="LHMATDF"/>
    <dbReference type="OrthoDB" id="3648173at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="47"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="300"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS17100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="424" mass="47421" checksum="707174ABF5844EA1" modified="2011-10-19" version="1">MSDTETVPENGAPWLSAPEDIPHDTRQVNIIVSASVCWVIAAFFVSLRFYTRGVIIHVLSWSDWCILLALIFAGATCAGLIDQAIHGSGRHVWDLDSTDTDGAIAWSRAAWYSILFYHLTLSFSKLSILLLYIHIFAFKWARKAGIVLLVVVLIVSVYMMLCTFTACIPLHSYWDFRYTGKKYCHPQSIWWSNTGLHMVTDFLIFMLPMPVVWTIKLPRRQKVILSFVFGFGFLVCFISILRLLKLIKMHTRPDPDWTYWAASLSYLTAVEVNSAIICASVMTLKPLLAKFWPRLLSSNPYSDSSSNSGGVRNRYRGSIGPGGPPTIGSKPSKVMRLSPVDEMMVSIERSATGGGKKGRGYVELEDNGSSTWNVDVEQLELTERGRTSGNAERGNSRLSVKRGKVRVDREVKIEVEVVARGAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G0RXX1</accession>
    <name>G0RXX1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0004590</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690999.1">
        <property type="nucleotide sequence ID" value="XM_006690936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RXX1"/>
    <dbReference type="GeneID" id="18254497"/>
    <dbReference type="KEGG" id="cthr:CTHT_0004590"/>
    <dbReference type="eggNOG" id="ENOG502QSKG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_0_0_1"/>
    <dbReference type="OMA" id="NNDADSH"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="365" mass="41063" checksum="CBA40B87663652EA" modified="2011-10-19" version="1">MLQKLTSVRFSYGQHEPSAVFDLRRLLGQLISTVAYCNLDATLLVGSNNQPNSTTNRPAILPASHWRSIPVDDNNDADSHLSESGSNASSTTSLRESLLEYRKLFGRTYHHELGQAESWLPNDEKHAASMELAHYAAILMTDSKLFLAPLDTNKSLKVLDLGTGTGHWAIDFADQYPSADDWSWPDNTFDFIYVRFLTGCILDWGHFYREAFRCLKPGGWLEHFEIGISWQSENPGGITPESPIGQMVQLFTEAGEKTGRTFRIVDDGLQTKYMKETGFVELGERDIHVPHGAWMEDATMKQVGIILGEALLEDLEGYTMYVFTAINGWAEEGARALTAHIRSHFKRPGLQAWVPRKVVWAKKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>G0RXZ8</accession>
    <name>G0RXZ8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="12">1.2.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0004880</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.12" evidence="12"/>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691026.1">
        <property type="nucleotide sequence ID" value="XM_006690963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RXZ8"/>
    <dbReference type="STRING" id="759272.G0RXZ8"/>
    <dbReference type="GeneID" id="18254526"/>
    <dbReference type="KEGG" id="cthr:CTHT_0004880"/>
    <dbReference type="eggNOG" id="KOG0657">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030140_0_3_1"/>
    <dbReference type="OMA" id="YGYTCNM"/>
    <dbReference type="OrthoDB" id="1152826at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05214">
        <property type="entry name" value="GAPDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000001">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000020">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
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                <person name="Kunze R."/>
                <person name="Devos D.P."/>
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                <person name="Cheng J."/>
                <person name="Bassler J."/>
                <person name="Fischer P."/>
                <person name="Lau B."/>
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                <person name="Kunze R."/>
                <person name="Griesel S."/>
                <person name="Kallas M."/>
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                <person name="Ruppert T."/>
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                <person name="Gese G.V."/>
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        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS23803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="5OQL"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="6RXT"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="6RXU"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="6RXV"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="7OLC"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="7OLD"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="7Z3N"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="7Z3O"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="8OO0"/>
        </source>
    </evidence>
    <sequence length="145" mass="15901" checksum="32F22F5ADED7866D" modified="2011-10-19" version="1">MSGGKPRGLNAARKLRNNRREQRWADLQYKKRALGTAYKSSPFGGSSHAKGIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKVTAFVPNDGCLNFVDENDEVLLAGFGRKGKAKGDIPGVRFKVVKVSGVGLLALWKEKKEKPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYH5</accession>
    <name>G0RYH5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">TBP-associated factor 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0006710</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691203.1">
        <property type="nucleotide sequence ID" value="XM_006691140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYH5"/>
    <dbReference type="STRING" id="759272.G0RYH5"/>
    <dbReference type="GeneID" id="18254709"/>
    <dbReference type="KEGG" id="cthr:CTHT_0006710"/>
    <dbReference type="eggNOG" id="ENOG502S5JC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015147_1_0_1"/>
    <dbReference type="OMA" id="KYSWMTG"/>
    <dbReference type="OrthoDB" id="21060at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007900">
        <property type="entry name" value="TAF4_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05236">
        <property type="entry name" value="TAF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID component TAF4 C-terminal" evidence="10">
        <location>
            <begin position="446"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="202"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="561"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="642"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="202"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="572"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="595"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="616"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="652"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="674"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS23961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="738" mass="78179" checksum="7A29547509982527" modified="2011-10-19" version="1">MAQPQPQVPQAPSQMPQAPHLQPLQPMTQMPQVPQQVSQMQQAHQGVQMGQRQAYSPPQLHAAPSQVSQQETTTMTPPPPPPPPPSTTTTTTTAAAAAAAAAPLPASQPATYGTVPPNKRPRVSPTLPTAPQQAQYVTAPFVSAPTTQGPVASPIAAASPSYINQHATPQATPTYIQKPQTYTAPYQNQNGVGISTVAANSAPVQAPTPTPTLTLPASPAPQSAPTSPPVTQQYTTAAIAPNAPPPPPTQGSMPPPARPTQPAKDAASIREPIKDIELEISDSLVSTGIDLRAEEQFLAELYSGSFSQDARTGLPANPPGPRTSFYGAGFANQPGESTELSQEAYEAQAAQRAWDEAAHRLAVVRSIELLSPFLNIANLHYRVDKIAKEHGIAVNLESKNASLGLGKLRSPTDFPQPKLTVTTKPGPDGAMVTTTGSWIPHDAYLADQLALLSIATKHRLRELIEDANNIAITRQKTSHGQIPKEWEDVSAPLRTGLDSLPDDMLVDGTADLNLKKRTYDAFAAAASSTSTTTKPLRGAKSLAEAVREAAKLDREIEEARLRKRQKRLNPESAQSGSRAGSAAPGTPGATGSTPEETKAPTKKEQKKASAARLAEANSTLSTNQTLSQLMGKRKKEYAWMTKAGSTPSTPRGGAGGADGGVGGGVGGKGGGLPEKAHHLTPDPRYPRLGTWREDKERGRNIQLRDWVHVLEMDRDRVEGRAVQEAYLKLDASGPKDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYI0</accession>
    <name>G0RYI0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S54 rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0006760</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691208.1">
        <property type="nucleotide sequence ID" value="XM_006691145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYI0"/>
    <dbReference type="STRING" id="759272.G0RYI0"/>
    <dbReference type="GeneID" id="18254714"/>
    <dbReference type="KEGG" id="cthr:CTHT_0006760"/>
    <dbReference type="eggNOG" id="KOG4463">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057574_0_0_1"/>
    <dbReference type="OMA" id="RYRQFWR"/>
    <dbReference type="OrthoDB" id="272778at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066:SF21">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01160">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS23966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="30681" checksum="FEE4BB7F59706905" modified="2011-10-19" version="1">MSFASTPVTRTMVLGLVGTSIAASLFDIKHYFDIQVGLHLFTYRQTWRALVYQLCYTNSSEVLFGAMALYHMRTVEQQWGSRKFASFVIVSGLLTAVLPPLILAVILRPLTFGMFDFLPAGPTPIIFAILAQYHAMIPHIYKYKVALTTGPPSANDADDSVPGITFSDKSTKYLMALQLAFFQWPGSLLGAGIGWLVGQAWRSELLPGALTRWRVPGWLVGMRGRKSNERFEGMRRRLESEGVSTAAASGAQHAGGVEGSNRRRTMGQQILDEVRGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYI2</accession>
    <name>G0RYI2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ADP-ribose 1''-phosphate phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0006790</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Highly specific phosphatase involved in the metabolism of ADP-ribose 1''-phosphate (Appr1p) which is produced as a consequence of tRNA splicing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ADP-alpha-D-ribose 1''-phosphate + H2O = ADP-D-ribose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:25029"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57967"/>
            <dbReference type="ChEBI" id="CHEBI:58753"/>
            <dbReference type="EC" id="3.1.3.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the POA1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.84" evidence="3"/>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691210.1">
        <property type="nucleotide sequence ID" value="XM_006691147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYI2"/>
    <dbReference type="GeneID" id="18254717"/>
    <dbReference type="KEGG" id="cthr:CTHT_0006790"/>
    <dbReference type="eggNOG" id="ENOG502S60W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054419_0_1_1"/>
    <dbReference type="OMA" id="LHACNTQ"/>
    <dbReference type="OrthoDB" id="2155246at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140291">
        <property type="term" value="P:peptidyl-glutamate ADP-deribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050892">
        <property type="entry name" value="ADP-ribose_metab_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12521:SF0">
        <property type="entry name" value="ADP-RIBOSE GLYCOHYDROLASE OARD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12521">
        <property type="entry name" value="PROTEIN C6ORF130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="8">
        <location>
            <begin position="163"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="72"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS23968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="342" mass="36325" checksum="D36578C6C85DFAEB" modified="2011-10-19" version="1">MPAKRSLKQTTLLGFVTSKKPRLSRSEQTHVSSSSDDPKKQVTEGRDEITSGTQKGGEESEDPKKTNVTSRSSLSPSATAQPQAAPSASASSSASSSAPTSTSTSTATSSVLAPPPPSSPTNSPNPQPSLSPTKPPSPTKAFTRIVPHTGSLFPTAPPNTLLIHACNTLGSWGGGIAAQFARLYPSAYKVYKSHCVRHKHNRGELVGRALLIPPLDSPSLPGLKEDGKGDGTGPGVRGHYIGCLFTSLAYGKKRDSEDKILAATAKAWRWLMRLVCEAEEGGEMIREVRMCKINAGLFGVPWESTKRAIEGVELREGEVPNVGRVEGEEGCRVEVQVWEIGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZM0</accession>
    <name>G0RZM0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Arp2/3 complex 34 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0003440</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690890.1">
        <property type="nucleotide sequence ID" value="XM_006690827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZM0"/>
    <dbReference type="STRING" id="759272.G0RZM0"/>
    <dbReference type="GeneID" id="18254382"/>
    <dbReference type="KEGG" id="cthr:CTHT_0003440"/>
    <dbReference type="eggNOG" id="KOG2826">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059439_1_0_1"/>
    <dbReference type="OMA" id="FRSYFHY"/>
    <dbReference type="OrthoDB" id="148331at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000003">
        <property type="entry name" value="Arp2/3 complex 34 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000005">
        <property type="entry name" value="Arp2/3 complex 34 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007188">
        <property type="entry name" value="ARPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058">
        <property type="entry name" value="ARP2/3 COMPLEX 34 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04045">
        <property type="entry name" value="P34-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS23648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="319" mass="36623" checksum="C83596196621456D" modified="2011-10-19" version="1">MLLLDYQNVLIQSILTERFAPGANPVSIDQTASDFDGVTFHISTPETKTKIMVSIQIRCFQDLLRYGADKVLNREYGPYVVPPEPGFDFSIVVDLTALPESQEEREALVNKIALLKRNIMAAPFEQAYEEHYQLKAEAAKFSSEEAPQGVREGGEVKAIHYREEEAIYIKASHDRVTVIFSTVFREETDRIFGKVFIQEFVDARRRAIQNAPQVLFRNDPPLELQGVPGVRNTGTGEIGYVTFVLFPRHLTPQRMPEVISHLQTFRDYFHYHIKASKAYIHSRMRRRTADFLQVLRRARPDNEEKERKTASGRTFKVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0S010</accession>
    <name>G0S010_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">tRNA-specific adenosine-34 deaminase subunit tad3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0008340</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691362.1">
        <property type="nucleotide sequence ID" value="XM_006691299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S010"/>
    <dbReference type="STRING" id="759272.G0S010"/>
    <dbReference type="GeneID" id="18254872"/>
    <dbReference type="KEGG" id="cthr:CTHT_0008340"/>
    <dbReference type="eggNOG" id="KOG2771">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024580_0_0_1"/>
    <dbReference type="OMA" id="HEPCVAC"/>
    <dbReference type="OrthoDB" id="3180714at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF156">
        <property type="entry name" value="INACTIVE TRNA-SPECIFIC ADENOSINE DEAMINASE-LIKE PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="3">
        <location>
            <begin position="198"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS23171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="414" mass="45841" checksum="AB92CE0A0ACBD742" modified="2011-10-19" version="1">MDEGGRSIKALLAAQEPVVKELIEDDIEHGVLVPLKTTLELRDDYQTGRVLITRVPTKAANPAIMLLRKLLPEEIIKGFPHLRRCAKPSDLPAHLKAELMNESPQSRQIHTGKSNWIYIIVGPENMLNRDEVAQALSSVEGIEGEVFLHSIPVPMVAPTSQVQAALWSQQFWPSLYRKNNPLGPHPSMIARQTEEIADDAAIWMALAHKVAKETHAKGYGEPIGACIIQREEGKTKVVSLAGDARWCPVGQMSGTGNPMAHAAMRAISMVAQKLVRAENKKTQTSPTPVLEFEAFQDSPNLDDEKKIFDIDHPNPDGYLCHGLEMYLTHEPCVMCSMAILHSRMGKVVFRHRMPLTGGLCAEERGRGHPALKGADGGRGLGLFWRRELNWSMIAWEWESGGAMKPLDVDHAVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0S038</accession>
    <name>G0S038_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0008620</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691390.1">
        <property type="nucleotide sequence ID" value="XM_006691327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S038"/>
    <dbReference type="STRING" id="759272.G0S038"/>
    <dbReference type="GeneID" id="18254900"/>
    <dbReference type="KEGG" id="cthr:CTHT_0008620"/>
    <dbReference type="eggNOG" id="KOG0098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_23_1_1"/>
    <dbReference type="OMA" id="ANGVMQY"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="179"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="285"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="33373" checksum="A48AF397BA465E6D" modified="2011-10-19" version="1">MSSPPWDYIAKLVCIGDSGCGKSSLTIRLCEGRFVTHHDVTIGVEFGSRIVPVGPPYSNSSESPLNNSSSSTTDDGNNSSTTAGGLPEPRIVPAEKPGEAPPHPQQKHMKLSLWDTAGQETYKSVTRSYFRGASGALLVFDLTRRSTFEHVTDWLNDLRQIAEPDIVVVLVGNKADLANAEPPSADNNSTQSPSQPPSYPYSPHQKKGVIGPPPRREVTRAEAEDWARRNGVLEYVETSAKSGENVEKAFMRVAEKIFQNIQAGKYDLNDRRSGVKGAHALQAGGTSGSGPGRGGGGGSVKLTGGNAKGVAGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0S046</accession>
    <name>G0S046_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetolactate synthase small subunit-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0008710</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetolactate synthase small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691398.1">
        <property type="nucleotide sequence ID" value="XM_006691335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S046"/>
    <dbReference type="STRING" id="759272.G0S046"/>
    <dbReference type="GeneID" id="18254909"/>
    <dbReference type="KEGG" id="cthr:CTHT_0008710"/>
    <dbReference type="eggNOG" id="KOG2663">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055003_0_0_1"/>
    <dbReference type="OMA" id="CARSGMM"/>
    <dbReference type="OrthoDB" id="2013116at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990610">
        <property type="term" value="F:acetolactate synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04878">
        <property type="entry name" value="ACT_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000001">
        <property type="entry name" value="Acetolactate synthase, small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="entry name" value="ACT-like. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004789">
        <property type="entry name" value="Acetalactate_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019455">
        <property type="entry name" value="Acetolactate_synth_ssu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039557">
        <property type="entry name" value="AHAS_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054480">
        <property type="entry name" value="AHAS_small-like_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053050">
        <property type="entry name" value="ALS_regulatory_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00119">
        <property type="entry name" value="acolac_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31242">
        <property type="entry name" value="ACETOLACTATE SYNTHASE SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31242:SF2">
        <property type="entry name" value="ACETOLACTATE SYNTHASE SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22629">
        <property type="entry name" value="ACT_AHAS_ss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10369">
        <property type="entry name" value="ALS_ss_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="7">
        <location>
            <begin position="89"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="299"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS23207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="325" mass="35395" checksum="F762BB9A7BDDCDA6" modified="2011-10-19" version="1">MASRSLFASSRRIAAQARDVPLSRGLAPLITVRHSSKSSSTSAIAYKALRRRHAPLPVDNPPAWSAQAAVSNILYETPTPSAAPPKRHVLNCLVQNEPGVLSRVSGILAARGFNIDSLVVCSTEVEDLSRMTIVLTGQDSVVEQARRQLEDLVPVWAVLDYTNAPLVQRELLLAKVNILGPEYFEELLAHHREITAADGVQQGENGQEAVEQPSLAETAKDFHPSRLVASEALRHKHEHLRNITYFTHQFGGKVLDISTNSCIVEVSAKPSRIDSFLKLIAPFGILESARTGLMALPRSPLYGPDEDSPMKEADEVVDASQLPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G0S067</accession>
    <name>G0S067_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Origin recognition complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0008920</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">ORC is composed of six subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ORC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691419.1">
        <property type="nucleotide sequence ID" value="XM_006691356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S067"/>
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            <begin position="223"/>
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        </location>
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            <begin position="572"/>
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        <location>
            <begin position="1"/>
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        </location>
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            <begin position="20"/>
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            <begin position="596"/>
            <end position="605"/>
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        <source>
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        </source>
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    <sequence length="780" mass="85974" checksum="61346E40DE898E8B" modified="2011-10-19" version="1">MAGSSRGRRTHYLPGVAREDSDDELGTEDYPWEWIYEDRNQAGEEPEASTESGRKRKRPAAATQEPQIVGARMGSFECYLGDTVLLKAEGSHEAWVGIICDFLTDEDGEKAANFMWFSSHQEIRNPKKRTDYLENELYITATYDINPLTTINGKAHVMSPAAFREKYPTGKVPRKAKEYGKVFICRRGCNTRTCTYTEEFVWEDIYSGRDDLDRLQDLIKRGTKATRRRKAAKEPSPEGDYNLEGDEEQDGEYSSGQPRTPKRPRTRDVITPSSKRKHLGSKPATPGSHRRVMVKKHLEFTPLATRVLSPLHVQSSPYQLARSQLHVAAVPASLPCREAEFSLVYSHLEAAITEGTGTCIYISGTPGTGKTATVREVVAHLDAAVRADELDDFIFVEINGMKITDPHQAYSLLWEALKGQRVSPAQALDLLEREFNHPSPRRVPCVVLMDELDQLVTKNQGVMYNFFNWPGLRHSRLIVLAVANTMDLPERTLSNKISSRLGLTRITFPGYNHEQLMRIVQSRLEGVPGDIVDPDAIQFAARKVAAVSGDARRALDICRRAVELAEADAAAAAAAQGGEEDDTDAPNTPSKRKNDSTAAASTLNKQSKKKNSRGRVTIETVRRAIAEATSSPLQQYLRALPFAARLLLSALVLRMQRSGLAESTFGEVLDEMQRAVKLAMVADSKALGALLKAATSAGGERDLANGHVGGLFSRGKNNDGMYLRPAGLSAAAVDLTGAGIINLEGHRAERPSKIRLAVGDEEVRLAFRDDPEIKALGIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0B2</accession>
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        <name evidence="4" type="ORF">CTHT_0009400</name>
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            <taxon>Sordariomycetidae</taxon>
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        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="entry name" value="Dsc4-like"/>
    </dbReference>
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        <property type="entry name" value="DUF1746"/>
    </dbReference>
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        <property type="entry name" value="DSC E3 UBIQUITIN LIGASE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
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        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="198"/>
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    </feature>
    <feature type="domain" description="DUF1746" evidence="3">
        <location>
            <begin position="83"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
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        </location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS23273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="358" mass="39236" checksum="4B1B89206333950A" modified="2011-10-19" version="1">MNHDPGPSSSSAARQLPPRPDVHRADDTDGAAGSRLRDRRNVLPEYNFGDRASGGPSSESWQREKQREGLAKKLEFVSHLQKSLDMIVIVYMCIIYYLECSLFRFLLRLIPHSAFLTPKDGLLLPAEQPHIYAIFLPGTLCILSHAFFSLPQAGEATRGYLHGGVIIDFIGQKPPTTRLTLLFFDLMILGLQCLMLAVHRERERLKKAVSPGLPTIGPSIDRAEQPTTAQASTTQDHDAEERGVLRDNPFIADGGDSIELQPLPEACNGREGGSGDEHNRGGNAYSSSRANVDMLDVLRSGNAVLSSFHIIHTVRAVASGVQAPGPAAYSLRTLGYNATLAALAAERRRRLLRGQQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0G7</accession>
    <name>G0S0G7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF3824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0009960</name>
    </gene>
    <organism evidence="3">
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        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691519.1">
        <property type="nucleotide sequence ID" value="XM_006691456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0G7"/>
    <dbReference type="STRING" id="759272.G0S0G7"/>
    <dbReference type="GeneID" id="18255034"/>
    <dbReference type="KEGG" id="cthr:CTHT_0009960"/>
    <dbReference type="eggNOG" id="ENOG502S1DF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013056_0_0_1"/>
    <dbReference type="OMA" id="MGIKGAI"/>
    <dbReference type="OrthoDB" id="5407645at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="662"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="671"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="685"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="741"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="750" mass="85569" checksum="37F7C6CBB920A988" modified="2011-10-19" version="1">MASYDHYDTPSSRERITTRRYYREERLDDREPRYYDSRDTYSRDLVPRGPPHTESELSIEEIRREFPPPGYSTRDLHRTRSTERGYYAEYDDRRAYYSRDRDRDHDREYDRKSRYYEEEKRKKARVLSKQQQILAAITGAAIAIGGKELYDRREAKEHGTDVQRNLLVSAALGAAGAFAGYQGTELYNKHKEKEERKAHAYRSGYYSDDELTEKEKKGHKNFLESALAAAGLGSAIKALTGESSKDERSETRSRRASRSRSRSRSRSRSHSHSRSRARSRSRSSGYSRDSKNDVASKIQKAAMASLIAGATEAFRISKQPGSWKGEKAKRILTAAAGAATLDAAQDPDKAGSKLGLAEAVLGGLLGNRMINGSKKNIEMDERTGRSRSRSRARSKDGSGGMGPLAALATAGLGAIAGKKLIENHERSRSRHRSVDSHDSRNHSPDRRRRRRRSSSSRSRSVVDAARRGLARIGIGNGPDDDEDSDHDRHDRSRSRGREHSREHRRSRGYDDHDDSHSRRRRDSYDDYDRDYEDDRRKDYDGDHFYHRDRSRHRRRGSASSADLGNSSADEKRGKKLRGKQILSTGLAAVATIHAAHSVYQSIEKRQQRQKAVREGRLSPEEAEKLKKKALLQDAAAVGIAALGIKDAISEIQEAWHKREELRQWKLEREEKRRRRAERRRRFFGAEDEDDDADDESDDQHRRHRASSWSAHSSGVDTEQTFYEGPHYIDGNPYSALPSPPRSGTTSPDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0L1</accession>
    <name>G0S0L1_CHATD</name>
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        <recommendedName>
            <fullName evidence="4">Secretory phospholipase A2</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">CTHT_0010400</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22571.1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0L1"/>
    <dbReference type="GeneID" id="18255078"/>
    <dbReference type="KEGG" id="cthr:CTHT_0010400"/>
    <dbReference type="eggNOG" id="ENOG502SU72">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053014_1_0_1"/>
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    <dbReference type="OrthoDB" id="5120271at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Phospholipase A2 domain"/>
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    </dbReference>
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        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015141">
        <property type="entry name" value="PLipase_A2_prok/fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40787:SF3">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40787">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09056">
        <property type="entry name" value="Phospholip_A2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="28481" checksum="2A903711592A75BD" modified="2011-10-19" version="1">MPFSSTDWRKFDNDDDLEDARAYIAQEVIPPVLDCLSGSVSLLTGSQEPLAGQSIVVFDLIALINMKFSLTAALLALVPAAFAFPATLETAAATLKRLSLTEITDQYLFSLTLPQFTAKRNARDPSTLIWDSDGCTSSPDNPFGFPFTPACHRHDFGYRNYKNQNRFTDANKLKIDDNFKKDLYYQCKGVTAETVCKALADVYYAAVRAFGGRTQSKKREDQEDLIREYEEKLAIYNKLVAEAQERGELWRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0M0</accession>
    <name>G0S0M0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tetracycline:hydrogen antiporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0010490</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988039">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF39">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="517"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="557"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="627"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="157"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="376"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="656"/>
            <end position="684"/>
        </location>
    </feature>
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        <location>
            <begin position="9"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="393"/>
            <end position="405"/>
        </location>
    </feature>
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        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
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        <location>
            <begin position="659"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS22580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="684" mass="73628" checksum="37D0C8A2F29F2C2F" modified="2011-10-19" version="1">MVHAAQIAASATPTTPSRLSSRRPQNSGSFHSGRRSSTGSFHAGEPFPQLPSYNDNLSGPSQRRKTPSAIVGPDLPRLRTGRSGRIRYHTFPTPPPLGLGSLSGKEQPWYKRLLWWSKGKVGLEDGFTSPGEHDDGTRRLPSGHHIDISENPLPWTQLCLLALLSLAEQTALNSIGPYLPTMVASFPEIPDGQEGVYVGLLASAFAMAQLTTNLLWGYLSDQVGRKPTMLLGSSLLMVCFVFFGLCRTYTQLLIVHAGMGLLNGNAAIVPTCLGEITDRTNQSKAFIWLPVIYSLGSITGPALGGLLVGVVAGEDYPFLAPNIFSAALLLASVVVLAIWFEETLSTIEPVAFDNKWINKARDWSLAGWHRLKQPFSRTPSDPWESYPINAAPNNSDSDFSSQSDNAPDEDDEHQRVLDHNAPDGSGEDEEAEEPKSAFRELANRNTLFILGTYLAFQVSNISFNSLYPIFAAAAPPTGRNLGPETIGLSLSFAGLVTVLFQMLVFHRLKDRLGNLGTYRYSLLGMALAMTLMPWVGHPDSSPPLGIGSGKLWLYVELGVALVLKNISAVGGLSSVMLLITNSASSHETLGTLNGIAQSLSAAGRSVGPFLSGGLFTLSTRVRPKGEALAWGLFAGFTLFGWFASLAIRGNGLESAGWVDESEDTEEDVDEEANGEGQEQALSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0M5</accession>
    <name>G0S0M5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mitochondrial ribosomal protein s24-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0010550</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691577.1">
        <property type="nucleotide sequence ID" value="XM_006691514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0M5"/>
    <dbReference type="STRING" id="759272.G0S0M5"/>
    <dbReference type="GeneID" id="18255093"/>
    <dbReference type="KEGG" id="cthr:CTHT_0010550"/>
    <dbReference type="eggNOG" id="KOG3419">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100590_2_2_1"/>
    <dbReference type="OMA" id="WVGILEP"/>
    <dbReference type="OrthoDB" id="407221at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_bS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020592">
        <property type="entry name" value="Ribosomal_bS16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_bS16_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919:SF20">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="Ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00732">
        <property type="entry name" value="RIBOSOMAL_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS22585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="92" mass="10546" checksum="F519A0357700C587" modified="2011-10-19" version="1">MVVKIRLARFGRTNQPFYNIVVAHARTARNSKPLEVIGTYDPVPKKDPYDPSGKLHKDIKLDITRAKYWVGILEPKYRPGLPPKHKPTVVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0S104</accession>
    <name>G0S104_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0011880</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691706.1">
        <property type="nucleotide sequence ID" value="XM_006691643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S104"/>
    <dbReference type="STRING" id="759272.G0S104"/>
    <dbReference type="GeneID" id="18255226"/>
    <dbReference type="KEGG" id="cthr:CTHT_0011880"/>
    <dbReference type="eggNOG" id="KOG0527">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1224624_0_0_1"/>
    <dbReference type="OMA" id="YWITSAP"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF161">
        <property type="entry name" value="SEX-DETERMINING REGION Y PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="123"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="123"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS22714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="225" mass="25553" checksum="EF5F6FA5C4F7B024" modified="2011-10-19" version="1">MMATSPIESHIKVADNSTRISFTFTGNEMIVHCNATADVSETTKLLQAAKKQYMTMNEGKKAAIVRCNGSDRYLVTGVQHALTLDENGFMVISSSDDAPSPLTTITADMKKSSRIGKIAKIHIRRPRNQFIIYRQWMSARMHAKHPDMTASAISQVVSRMWHEEKPEIKAHFKALADEEERLHKLRYPAYRFEAARRHHMQHFLASRHSIHNPVTMAAKLIISSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1C8</accession>
    <name>G0S1C8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0013140</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691830.1">
        <property type="nucleotide sequence ID" value="XM_006691767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1C8"/>
    <dbReference type="STRING" id="759272.G0S1C8"/>
    <dbReference type="GeneID" id="18255352"/>
    <dbReference type="KEGG" id="cthr:CTHT_0013140"/>
    <dbReference type="eggNOG" id="KOG1337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041939_3_2_1"/>
    <dbReference type="OMA" id="ISHMKDE"/>
    <dbReference type="OrthoDB" id="441812at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF137">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="34"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="447" mass="49835" checksum="6E92A32C062BBEE9" modified="2011-10-19" version="1">MISRTTDSTQPQDNTTEAHTNLLAWAQEQGIKLNGVKPRALPGRGLGIVATRPLQPNETILHISPSCFRTADTARPRLRKLTSSSFAGGGSSSSNTSLSSHAILAADLALDFAKPNSPRSQRNAPWTAVLPSQEDLFSCLPLAWAETGVWPDIESYLPPAARKILSRQRGEFSTDWDGVKDVLEKDGVTREAYLHAWGLVNTRSFYWHVHHPRHHHHHQHLHGDDSHHHGSTSSGREDRICLQPLADLLNHSSSSPHLCTATFTSTGFHVRTTTPLPEGSEILVRYGRHANDALLVEYGFLPSDLNPWDETPLDDAVIPLFNSQLKELLEENGFWGGYVLDAKTVCYRTQVALRLLLLWPDGPGGIARWKRWVDEGEDGGEEVQRRVDGMLVGILEKYLNETVERMVREVEGCKGGTESQRQVVAERWRQIGRLMRGTIERLACGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1G0</accession>
    <name>G0S1G0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Phosphatidylinositol N-acetylglucosaminyltransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0013470</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGC family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691862.1">
        <property type="nucleotide sequence ID" value="XM_006691799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1G0"/>
    <dbReference type="STRING" id="759272.G0S1G0"/>
    <dbReference type="GeneID" id="18255385"/>
    <dbReference type="KEGG" id="cthr:CTHT_0013470"/>
    <dbReference type="eggNOG" id="KOG3059">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024002_1_0_1"/>
    <dbReference type="OMA" id="ILWDSWV"/>
    <dbReference type="OrthoDB" id="196709at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009450">
        <property type="entry name" value="Plno_GlcNAc_GPI2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06432">
        <property type="entry name" value="GPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="384"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="469"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="208"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="264"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="331"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS22870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="536" mass="57251" checksum="F9B29A2AED2333DF" modified="2011-10-19" version="1">MAPPPGPHIQSAIPSDTETPFPKLVRSSTLPASLPTSSRSSSLHHRSSSHLSPEDAYAPTSPPRRATPYANSAAGNGPSADDRRRIRHNDGSRSRSRRRKRFQKLLWVKQSYPDNYTDQATFLENLQRNPRVRPYDFWPLVADTTVIVQHVCSVIIFIVCFVGIFQERVSPVAVVGWSSFATFVGWLIWDYWVTQELQSLPPDHEARTLIGREYPPPPAPPPSLRRQDSTGPGRPSIATSIVTSTSNLPSAASSTTNLLQDQNASLQASQPQNNGENSTTTGSNGNGNGSSNNGENGNGSGNTLLVPGHPHSRSVSSLNSISSQASTTPNPANPPTPNVTTPPPSSRMYARISTIKSAILIYFTLLGLSPILKSLTRSTSSDSIWAMSFWLLALNIFFFDYSGTSWVGRGTGSSSSATAAAVAITSSSHAPGPGPGMKKKKMPVASLSTNAALMASTVLASRLPSTGQVFSLTLFSIEVFGLFPVFRQLARHRSWRYHVLLTVALVCGAGAGVGIILGDPARPCEAVGVSGELGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0S224</accession>
    <name>G0S224_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LsmAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0015730</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS23084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692076.1">
        <property type="nucleotide sequence ID" value="XM_006692013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S224"/>
    <dbReference type="STRING" id="759272.G0S224"/>
    <dbReference type="GeneID" id="18255611"/>
    <dbReference type="KEGG" id="cthr:CTHT_0015730"/>
    <dbReference type="eggNOG" id="KOG2375">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007072_0_0_1"/>
    <dbReference type="OMA" id="RMQMSAS"/>
    <dbReference type="OrthoDB" id="2275718at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045117">
        <property type="entry name" value="ATXN2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009604">
        <property type="entry name" value="LsmAD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854">
        <property type="entry name" value="ATAXIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854:SF7">
        <property type="entry name" value="ATAXIN-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06741">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01272">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LsmAD" evidence="2">
        <location>
            <begin position="227"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="685"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1072"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
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        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="404"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="436"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="595"/>
            <end position="625"/>
        </location>
    </feature>
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        <location>
            <begin position="645"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="685"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="695"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1075"/>
            <end position="1092"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1092" mass="117947" checksum="62D4842A71D160B8" modified="2011-10-19" version="1">MEDRSSASKTAANPSLASTPSSTPTNSRPLYSSKLAADRSKPQEGTAAPPSARQPPVQKAWTSNRNPITGRTSVPQNKQSVTSSLREGQRVRIVLHNGAEFEGIYNNGPDPTSCRLTMVQQKKLPNSSDAANGPNRREQSTMTFQRKDIAEARVVPGNVNKSDGRATNGNRNSFRPDSAIANPRFGNERQLKPWVPEGGFPSDLDAPLEKSTSSGHWDQFAENERLFGIKTDYDENIYTTAIDKNHPQYKERLAAAEKKAREIERSAPVTAHHAEERIMDYVGGDDHDEEAKYSSVQRQQDFPPLTSRENKYTPPAKRAPTGQPTVKGAPMDPAIIASALKTTSSSSTPKPQLPTRPAEQPKPAEQPKPVEQPKPAPPATEKPAEKPAAPAAETPAGPKPSSPAPAETKAPETTASAPKPSDSKPSESKPAETKDAAASTAAKPAAPTTTAATTTTSTASTSAAAPIRPSAATARVASQAKVSTLPTATTIEREVLSSFRTFASSQRYLHEKVRSAKAKVDKEVRLSELKKFAENFKLSTPVPKDLVPIIAKDPVKQKQIQEKALQDAAEARQRREQALREKEAQLAKEKEAKAQAEQQATATTSATPAPATTATADARAPARPAGPQQSGSTMGLSGRHPGARSSYSAQPHYQYNRNGRPAPHLGGQAAQTGNLAQRLRNVEQQKMQHPHMAQHPPPEMRLPPTGPANIDPNYGRRISGVPPTYLGPKLNPNSHEFRPNAFAAPFNPAIPSQGSSPRSSVNNVAEVAPIPAPPAKGPLVRRKTKAVDIKKCYILSHIETIQPPQGRNWDENDGLRPSYETIPTWRQLQDESTEAPDSTMRLTFNEYFEKQPLPNAAVATPNPGHVMPQMPHQHQLPYHLQHGAQNLVPRQSPHLVPMQMHAGQHGHVPHVPFTAPDDHRMMHSNSAQSFASPRMGQVPIAYPPAMQAPAQIPYGQPVMQPYVTPAPQMGQFRSFSHNPQFIPQQPHHMAAPMMVQPQFISAPNGMVAAGPMYPGAHPQFIPAGAVPPQPIPVSNGFPSPGRPAAPMMVPQGSHQGTPAGQAVYGMSPAMPYQQPVYTSQQPQGKFSGQRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0S294</accession>
    <name>G0S294_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP synthase subunit 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Lipid-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CTHT_0016430</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the ATPase C chain family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692146.1">
        <property type="nucleotide sequence ID" value="XM_006692083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S294"/>
    <dbReference type="STRING" id="759272.G0S294"/>
    <dbReference type="GeneID" id="18255681"/>
    <dbReference type="KEGG" id="cthr:CTHT_0016430"/>
    <dbReference type="eggNOG" id="KOG3025">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116822_0_0_1"/>
    <dbReference type="OMA" id="MKRQTIQ"/>
    <dbReference type="OrthoDB" id="438052at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033177">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, proton-transporting domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18182">
        <property type="entry name" value="ATP-synt_Fo_c_ATP5G3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.20.10:FF:000006">
        <property type="entry name" value="ATP synthase subunit 9, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="ATP SYNTHASE LIPID-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031:SF13">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0138">CF(0)</keyword>
    <keyword evidence="9 17" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="12 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 17" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 17" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="18">
        <location>
            <begin position="87"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGS22127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="173" mass="17827" checksum="91DB4AEED85CBF6F" modified="2011-10-19" version="1">MASTRVLASRLAAQMATKAARPAARVSLANASKRTMTVASKASPLQAVKRQQASAIVSATTRQAFAVQRRAYSSEIAQAMVEVSKNIGMGSAAIGLTGAGIGIGLVFAALLNGVARNPALRGQLFSYAILGFAFVEAIGLFDLMVALMAKFANETGGGVHGRMAWNLSIDGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2K6</accession>
    <name>G0S2K6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenosine 5'-monophosphoramidase HNT1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Histidine triad nucleotide-binding protein HNT1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0017560</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>adenosine 5'-phosphoramidate + H2O = NH4(+) + AMP</text>
            <dbReference type="Rhea" id="RHEA:67916"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57890"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:67917"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HINT family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692258.1">
        <property type="nucleotide sequence ID" value="XM_006692195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2K6"/>
    <dbReference type="STRING" id="759272.G0S2K6"/>
    <dbReference type="GeneID" id="18255794"/>
    <dbReference type="KEGG" id="cthr:CTHT_0017560"/>
    <dbReference type="eggNOG" id="KOG3275">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056776_3_0_1"/>
    <dbReference type="OMA" id="YRVVMNC"/>
    <dbReference type="OrthoDB" id="672793at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01277">
        <property type="entry name" value="HINT_subgroup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000013">
        <property type="entry name" value="Hit family protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039384">
        <property type="entry name" value="HINT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648:SF1">
        <property type="entry name" value="ADENOSINE 5'-MONOPHOSPHORAMIDASE HNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="HIT FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="12">
        <location>
            <begin position="5"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="10 11">
        <location>
            <begin position="96"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="9">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS22239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="136" mass="15239" checksum="793540B7390C72F0" modified="2011-10-19" version="1">MASCIFCKIIKGKSSEIPCFKLVETEKSLAFLDINPLSRGHALVIPKVHGEKLTDIPDDFLTDILPIAKKLVKATGAEEYNILQNNGRGAHQEVPHVHFHMIPKPNQQEGLGIGWPIQKTDMDKLKALYEEIKDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2N8</accession>
    <name>G0S2N8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0017900</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692290.1">
        <property type="nucleotide sequence ID" value="XM_006692227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2N8"/>
    <dbReference type="STRING" id="759272.G0S2N8"/>
    <dbReference type="GeneID" id="18255828"/>
    <dbReference type="KEGG" id="cthr:CTHT_0017900"/>
    <dbReference type="eggNOG" id="ENOG502S9YF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1562708_0_0_1"/>
    <dbReference type="OrthoDB" id="2311180at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS22271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="171" mass="19251" checksum="F410317ED03AE695" modified="2011-10-19" version="1">MAPTVLESPTDVAGELPIGDAHIFIDNSNLWIAGQRTYAERMGLQVSWDPTWRSDIEWLCTVILQNSNLTPEEQQYDVKVNLYGSIPPPVDTFWKKIDSYNVRVSVLARSTWTKKEKQVDAKLVAECVKTAAEAHFKEIPSVFIIVSGDRDVHAAIQTIAGDYSHKVHLWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2Q4</accession>
    <name>G0S2Q4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0018080</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692306.1">
        <property type="nucleotide sequence ID" value="XM_006692243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2Q4"/>
    <dbReference type="STRING" id="759272.G0S2Q4"/>
    <dbReference type="GeneID" id="18255846"/>
    <dbReference type="KEGG" id="cthr:CTHT_0018080"/>
    <dbReference type="eggNOG" id="KOG4178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_20_1_1"/>
    <dbReference type="OMA" id="MLTFRHG"/>
    <dbReference type="OrthoDB" id="19657at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF5">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="67"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="391" mass="43263" checksum="D4EBE926C7AD5277" modified="2011-10-19" version="1">MLLPPVKGPQLPTVAETLTLDAFPTAVYNLEPDQKGLCPVAEGRGGPFNMSWEIHGEGPIKLMFIMGLGGLKSAWQRQTLYFGHERRDKYSVLLVDNRGMGDSDKPLMRYSTSEMAKDLAEVLAHIGWIPSFPLPSDPALIQRVLHIVGISMGGMIAQELAVLLAPAISTLTLCNTAAVMEPAGSFTENIKHRLGFLVPKSVDRSVSDAARQLFSHKWLLEPDNARVPDPKITPKCHPPAGPAIEANGKASKGTANDSAEESVNKPQEYLTFPTNAHRFIAQELHKRADRSRFPTTGFLLQLIAAGWHRKTPEQLREMADAVGRERIAIMHGDHDNMISLKHGQKLIEWVQPGQKYIIEGCGHVPMVEREGWFNEVMEERCAFGEKMDGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2S3</accession>
    <name>G0S2S3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0018290</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692325.1">
        <property type="nucleotide sequence ID" value="XM_006692262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2S3"/>
    <dbReference type="GeneID" id="18255867"/>
    <dbReference type="KEGG" id="cthr:CTHT_0018290"/>
    <dbReference type="eggNOG" id="ENOG502QSKG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_0_2_1"/>
    <dbReference type="OMA" id="QPARSTH"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="41568" checksum="960E725785551B5F" modified="2011-10-19" version="1">MSPRLAGSAGELRGNNCEEMAATSSAPPNPGEASMPDGILPASHWQQTQLPAVNDDADSAYGSQWSETTSLSSSVRRYRVLQGRTYHADIGAAESWEPNDNRHIESMDLLHFMVTLVMGDKLFLAPVENPQKVLDVGTGTGLWAIEFGDLYPGAEVIGTDITPIQPSWVPPNVRFEIEDANLDWAREDNTFDFIHARTLTGNILHWDHFFAEAYRCLKPGGWLESQELDFGWKVLDGEIPEDSAMGQYVKVWHAGGEKTGRSFRVVDDNLQEKWMERAGFVDIEVKDLFCPYGAWPEDPREKEAGILSKAAFENDMEGYILHIWHAVLGWTPEEIQNYVAHLRRELRNPNLKIYFKRRVVIGRKPQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2V3</accession>
    <name>G0S2V3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative fungal specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0018600</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692355.1">
        <property type="nucleotide sequence ID" value="XM_006692292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2V3"/>
    <dbReference type="STRING" id="759272.G0S2V3"/>
    <dbReference type="GeneID" id="18255898"/>
    <dbReference type="KEGG" id="cthr:CTHT_0018600"/>
    <dbReference type="eggNOG" id="ENOG502RJRW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_342880_0_0_1"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="323"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="10"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="384"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="399"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="455"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS22336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="826" mass="90149" checksum="ABA86A4F84FCDC13" modified="2011-10-19" version="1">MTFNFNLGAGFNPTFGRDPGPPPPGNSLAAQSIPLDSGPPPPYTTRSAQAPVIYHWTTQPSGPGIPPITYYFTINPSNPAGPVTILYCHVGYPNSSGMATAQTALAAQPAQPQAFAGVGVGLPANGIGTTWAIDANGQYYQYVSGINNSGRVPQPAPLINPDFPAGNLINSTGGVGLEPGYNYFFQTDHANVVRLMCPTEPWKLQPGTYDAIEFMPVKVPASTTMEQWFVGNGVDHPDKSLNQMWEVYPKGGGAWGWKEHIRGDDEVMMKRTVREMGWCEKRGGQLPTVIGGNPLHLTVTPNAPRMTPDGRSERQRRRKIPLACEPCRIRKSRCDGAKPICSTCRRRSLPLHQCIYTLENARTASNEAYIRVLHDRIRRLERLCTDHGIPTPPIDSVSDDARSPSEPRTDPHSLNPAPRPGETALQPPDPPTRSLPEHAPSPAVSRCRHSAGTPEPDRLDDTEIRTSITAMGTVSTEDDACQAFEAVNEFYGSSSAASFMKEACLGLGSSPGADSSTIVFHCALNGIFAIGCQFADLNPREKLTAVETFFNRAKAFVGLDFLDMHNVGVVQALLLMALLLQSTPFASRCWNSVGVACRVAQGLGLHTESGRTARSPLETEIRRRTWHGCVVLDMIVCMIYGRPTMTAHLPSLSLPSTEEFDGEERLPPSVPSRMNFYLEYIRQCRILGEILSSVYQSSQGGTPGPYTAAYQEDSRPHGMDEILKLDDKLTRYESDVNPLLSWKNPCDINAFTGGLAVILAYLCPALVESLDKTRLESAWMACQEILTHFASFSISAHRSLKLLRKVHADVMSHVSSGVDMRSSNGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0S317</accession>
    <name>G0S317_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0019310</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_006692419.1">
        <property type="nucleotide sequence ID" value="XM_006692356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S317"/>
    <dbReference type="GeneID" id="18255969"/>
    <dbReference type="KEGG" id="cthr:CTHT_0019310"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_12_0_1"/>
    <dbReference type="OMA" id="AITVGYW"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000017">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004762">
        <property type="entry name" value="Amino_acid_permease_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00913">
        <property type="entry name" value="2A0310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="484"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="513"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="555"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="597"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="10">
        <location>
            <begin position="160"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS22400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="669" mass="73140" checksum="FD05A63FB0AE4686" modified="2011-10-19" version="1">MAHDIELSHLDKQQHVSASGSILTAHDEGHTPSHKSMSTVPQPSTSSQQPLDDYHNSRYSSDPADDDDAQHDHTFRGHFNHFIDSFRRQNPPSYYSSSNRSSLPRSLTYCDDFDVDLERHQPIRRRPRHKHKEDGRFFDLRSASTKTASTLLARELKARHLQMIAISGSIGTGLFVASGKALSEGGPASVVLAYVLVGVMMYCTMQALGELAVVFPVAGSYSAFSTRFLDPSWGFAMGWNYALQWIVVLPLEVIAGALTIGYWNPGLSRAIFVTIFLLVIIVINLCGIKGYGEAEFVFAIVKVTAVVGFILLGIVINIGGTPTSGYIGGRYWRDPGAFNNGFKGLCSVFVTAAFAFAGTELVGLAAAETANPRKSLPTAIKQVFWRITLFYIVSLTLVGLLVPYTEPRLLHASSIADASASPFVIAIESAGATILPSVMNGVILISVISVGNSSVFGSSRTLAALAEQGQAPKILAYVDRRGRPLVSILVVSAVGLLAYLADSHGHGRVFDWLLAISGLSSIFTWASTCLAHIRLRTAWARAGRSLEEMAFRAQAGIWGSWLGFALNVAILAAQIWVSISPIRSGEDANKPLSASDIAYSFFVQCLALPVVLVMWLGHKLWYKTSYVKIEDMDIDTGRRDIGRLDIIKAQEEEDRATWPTWKKVYRFIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3D2</accession>
    <name>G0S3D2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0020590</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692534.1">
        <property type="nucleotide sequence ID" value="XM_006692471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3D2"/>
    <dbReference type="GeneID" id="18256097"/>
    <dbReference type="KEGG" id="cthr:CTHT_0020590"/>
    <dbReference type="HOGENOM" id="CLU_1239995_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="223" mass="24099" checksum="04C7D89EF749C1FC" modified="2011-10-19" version="1">MNHWLPQSGRVTKVYPAKSSVCIEVSKSSLRETLARKAKEAWYTIEPETITDAYLVKNVPEYILAYDGSRRPTDPAIADEVISVTKQKEVSAHAVKDSPGIYLVILRHKVSPSSPPPFPGYSTQTSNPAQEEGAHLHDQRKAVRKAGNAAYRAAKKVASDRQNDSSHSPPNPSPNSSPTPEPTRPEAEDTVISDALPVHPAAPQASAPQVDTALPDSRPTAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3D4</accession>
    <name>G0S3D4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetylgalactosaminide beta-1,3-galactosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.122</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0020610</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.122" evidence="4"/>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692536.1">
        <property type="nucleotide sequence ID" value="XM_006692473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3D4"/>
    <dbReference type="STRING" id="759272.G0S3D4"/>
    <dbReference type="GeneID" id="18256099"/>
    <dbReference type="KEGG" id="cthr:CTHT_0020610"/>
    <dbReference type="eggNOG" id="KOG2246">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022549_1_0_1"/>
    <dbReference type="OMA" id="WYLFVDA"/>
    <dbReference type="OrthoDB" id="414175at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000039">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF40">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="14">
        <location>
            <begin position="225"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="71"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS22517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="530" mass="60549" checksum="0AED0EC49F95637C" modified="2011-10-19" version="1">MPLLAPGSPGTSPVRLRLPVRRSSTILLVFTILSFFMLVYASRRITNWSMMDGPNAPYRSEYSPMGVCPDGENCSHATQPNSVKQSETASSISSTSFTESTPPPAPPQPQDPLCEGFPNTSSVLLVMKTGASEAFARVPTQLMTNLRCLDDFLIFSDMEQDIAGFHIYDSLDKVLPEARSGNPDFDIYRRQQWCFIDQDSCNKLGDPAKEGWSLDKYKNIHIAEKTWAMRPNYDWYLFVDADTYVVWSNLMQWLSTMDPNKKLYLGSVALIGNFPFGHGGSGYIVSRAAMEEFVGKHPGVGNEFDVRARKECCGDYLFAVAMENKTGIKVQHMWPTINGEKPFTLPYGPSHWCHPIVTMHHLNSDEINSFFNFERKFLESHPPGTTILMRDIYEHFLAPNLLRIRADWDNLADNRFYLDLTRPGGRSYWDDWMVKRMKKDEELNEMEKNAHLSFEACENACRSVSEHECFTFRYQNGMCAFGNAFKIGKPVKRDDTKGSMMSGWLTERISEWIQKQGECKVKWPTPEYKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3N7</accession>
    <name>G0S3N7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0030050</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693459.1">
        <property type="nucleotide sequence ID" value="XM_006693396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3N7"/>
    <dbReference type="GeneID" id="18257043"/>
    <dbReference type="KEGG" id="cthr:CTHT_0030050"/>
    <dbReference type="eggNOG" id="ENOG502SN7S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094654_0_0_1"/>
    <dbReference type="OMA" id="YMRYSGH"/>
    <dbReference type="OrthoDB" id="5409477at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="257" mass="29356" checksum="7B7E34915B008BBE" modified="2011-10-19" version="1">MYPRNLSTVGKGVIRMDPDCAICHAPASLACECEAKGLELAVRQAEARMMNQIYNDIRSWVRAHAQDYILEYFRVLTERRKQAHQQHLERLQAQYRYYHQQPHPSQIADAQAALKRGIDEDWQASVQRYPEVLEYFFSLVELTLPDDNDAAVKDPPLSPLNSLRKRDGPPPAPTRRMTVGERDRPDRDRGAATTVVSGPSMALHERDIPPPLPRGRTPPPLEPLRERRTPAPRERRHSYRPPPPPPPPPAGYGYPPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3Z6</accession>
    <name>G0S3Z6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0021990</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692668.1">
        <property type="nucleotide sequence ID" value="XM_006692605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3Z6"/>
    <dbReference type="GeneID" id="18256237"/>
    <dbReference type="KEGG" id="cthr:CTHT_0021990"/>
    <dbReference type="eggNOG" id="ENOG502R6SS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_614209_0_0_1"/>
    <dbReference type="OMA" id="YREHSKS"/>
    <dbReference type="OrthoDB" id="3439480at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="366" mass="43014" checksum="690C888AF76598A2" modified="2011-10-19" version="1">MCRKEIYFNTYADGDEVVTEKMYPCRDGHRCSRPDVRTYNRKFPFSRLSNLGSESHRSLSERIPTPYFPDYVSSSKSSSSRRRNSEVYSKGVKSNKHYDYDDPYILLDPYDYQRSSRRERDRYEKESSKSKHSSSTPLIVYKDRDSRSRSKGREYSDDISIGLADDYDRRRSRDDSRDGSDSRHRRRNSVDIPDYVFVEESSRPRERRRMSMSSYPEPTGSRSRTGLNAYAYTEPLRRSSTVIHHSDGSLSKPKQLRWEDEVRAKRAKQNAEIASRPALVSSSGEPLKGILKRSNSDSYRTSSKGKDRDWDDIAELRGAVERMELSRGRDRKSKVLGEDWGGFSHFDDDYGEKRRKRGRWDENYWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0S494</accession>
    <name>G0S494_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">64 kDa mitochondrial NADH dehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0039370</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS22052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694348.1">
        <property type="nucleotide sequence ID" value="XM_006694285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S494"/>
    <dbReference type="STRING" id="759272.G0S494"/>
    <dbReference type="GeneID" id="18257975"/>
    <dbReference type="KEGG" id="cthr:CTHT_0039370"/>
    <dbReference type="eggNOG" id="KOG2495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021377_1_1_1"/>
    <dbReference type="OMA" id="HVDVLTN"/>
    <dbReference type="OrthoDB" id="5376590at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.100:FF:000002">
        <property type="entry name" value="External alternative NAD(P)H-ubiquinone oxidoreductase B1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.100:FF:000005">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 64 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF50">
        <property type="entry name" value="NADH DEHYDROGENASE (UBIQUINONE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="526"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS22052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="685" mass="76568" checksum="EF1D2F85326B24D2" modified="2011-10-19" version="1">MLGRSIGRGRSASLRPGGTATARMGLKFDYESLAQQRIQRLFSHHHGLHLVLSRYISSDPLPRKGSRALRIAYRLAALLGSAVVVLGIGIVGFFIYDASTYATEHANQREVDVAALALNPRHGGPKNLPILEVCLDDNDSESMRRQKEKPRLVILGGGWGAVSLLKELEPENYHVTVISPKNYFLFTPMLPSATVGTLGLRALVEPIRRIIHAVGGHYVRAQAENVDFQSRLVEVSQTDCNGNEQRFYVPYDKLVIAVGSVTNPHGVKGLEHCHFLKDINDAREIRNKVIQNLELACLPTTSDDERRRLLSFVVCGGGPTGVEFAAELFDMLNEDLIQLFPKLLRNEISVHLIQSRDHILNTYDETLSKYAEDRFARDQVDVLVNSRVREVHPDSIIFTQKQDDGTIVTKQLPMGFCLWSTGVSQTPFCKRLAAKLGSAQTNRHALETDTHLRLNGTPLGEVYAIGDCATVQNNVADHIVSFVKRSLTWKHGASAVDTDPSKLHLRFNDWRAIAEQVRKRFPQATDHLKRLDKLFAEYDRDKSGTLDFAELRELLVQIDSKLTSLPATAQRAHQQGQYLAKKFNALARAVNSGRLIRELAKAEETPDVDAAVYKAFDYKHLGSLAYIGNSAILDLGHGRGFAGGLWAMYAWRSIYFAQSVSFRTRVLMAMDWAKRGLFGRDLMSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4C6</accession>
    <name>G0S4C6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Microbial-type PARG catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0039700</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS22084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694380.1">
        <property type="nucleotide sequence ID" value="XM_006694317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4C6"/>
    <dbReference type="STRING" id="759272.G0S4C6"/>
    <dbReference type="GeneID" id="18258008"/>
    <dbReference type="KEGG" id="cthr:CTHT_0039700"/>
    <dbReference type="eggNOG" id="ENOG502RY8X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024412_0_0_1"/>
    <dbReference type="OMA" id="GCGVYGN"/>
    <dbReference type="OrthoDB" id="9985428at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012664">
        <property type="entry name" value="CHP02452"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019261">
        <property type="entry name" value="PARG_cat_microbial"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02452">
        <property type="entry name" value="TIGR02452 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596">
        <property type="entry name" value="DUF2263 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596:SF1">
        <property type="entry name" value="MICROBIAL-TYPE PARG CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10021">
        <property type="entry name" value="PARG_cat_microb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Microbial-type PARG catalytic" evidence="2">
        <location>
            <begin position="100"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="390" mass="42592" checksum="CDCB6C72FF512CEC" modified="2011-10-19" version="1">MLRKKYYNNPKRLALAAIAKETSELTLTVAASLPRLNPTHSEKLSLETLPALDPAKCPRFKLPDSTYGTRVRVFNQDTFDAALSMPAIVLGISSFQSKATQAKESEILTQLQTHASLPDQLNATTAPRVAVLNMASEFSPGGGWLKGSTAQEEALCYRSTLAASLHKNMYPMAPRTGHYTRDVVVFREGMDRGHTLLIKGKGSDGKGIPDEELPVASVLSIAGVRKPAVKGKGEVDESGSSSKTDQPAKEKNDESPAKSGESRVKGHFKENWKDRKGQPEGNKPKIPKGDLVFADPAVRALTKDKMRLCLRMAASKGHTMLVLGAIGCGAFGNPPREVAACWMEVLSEREFEGGWFKEIWFAVYDRRKEGNFEIFSEVFDGKVVGQPTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4I9</accession>
    <name>G0S4I9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Class E vacuolar protein-sorting machinery protein HSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Class E vacuolar protein-sorting machinery protein hse1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CTHT_0022990</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the STAM family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692763.1">
        <property type="nucleotide sequence ID" value="XM_006692700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4I9"/>
    <dbReference type="STRING" id="759272.G0S4I9"/>
    <dbReference type="GeneID" id="18256337"/>
    <dbReference type="KEGG" id="cthr:CTHT_0022990"/>
    <dbReference type="eggNOG" id="KOG1118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002632_0_0_1"/>
    <dbReference type="OMA" id="CQAITSP"/>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11883">
        <property type="entry name" value="SH3_Sdc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056685">
        <property type="entry name" value="DUF7783"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056686">
        <property type="entry name" value="DUF7784"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057827">
        <property type="entry name" value="WW_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF368">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25006">
        <property type="entry name" value="DUF7783"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25008">
        <property type="entry name" value="DUF7784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23518">
        <property type="entry name" value="WW_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="18" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="9 12" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SH3" evidence="15">
        <location>
            <begin position="84"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="17">
        <location>
            <begin position="798"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="16">
        <location>
            <begin position="968"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="147"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="219"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="151"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="236"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGS20467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1204" mass="135045" checksum="72EEAB7064328413" modified="2011-10-19" version="1">MLMTQNTASAFQGQNNTATTAAAYSDQNTLAGSGAARHQHSYSTASTASDVRSADGDFTYTAYFNGNNADTTSIMNGIVGTVPPGTMYVRALYDYEADDRTSLSFHEGDIIQVITRLESGWWDGVINGVRGWFPSNYCQIISPEELREQEGIGEEQVEEESEEQQEYEETLDEEDGSDHDDGDNLPLEGTEVGRSRADFWIPQATPDGRLFYYNTMTGESSHELPLEPPSSINETGPHDRMNVTIPDRTRPPPEMIARGLTQEEEESDLTSASDLEGENRPSAARVRPQMRRHNTTDGISPSTSMDSINGQPSMTRSRGDTFANGSMIQPPMITSATSFTSTTYNLPTAATIPRSFFDDGGAPPLTWSRLVSAMKKAIDRYRQAIESGNRAEYVARAEDISDHLRLLLAAGSGTTDNHSGQPSIISTNKALYPHFRDMMSKFSKLVISSHIAAADWPNAESVQKCLQEADGVLLGVYSYVEVARQQRGEEIPRLFPGFVLGSNTGGSWQNNGLGPRDPITSNFLDDDEGVNEPSALLDGKLLERLEEMKRVLVSSIRELDKYLVCTDKLITAYKHEVIGNNVCTAGSKVLDAFKPWIATIESIDLSILGDTFQTPQLADFSMNKQSLYDNISDLLLGCQAVCGPLADEWSEIRGQALEERLEYVRQCARALETNSSHIGFSLQLLSEQVAMVLQQQDLDMQRELRRIDAMPYDRPHQRSDSRSFIRPGLGLGAQFADGEALPNYRKAGDPSKMKKFFGEDPLIDPSLQQQIQPPVVDDTPDFLKLDHDKDLSWDMKVNPPAVKGGSLIALVEQLTRHDKLDANFNNTFLLTYRSFTTARELFELLVQRFNIQPPEGLTPEELDMWREQKQKLIRFRVVNILKSWFDQFWMEDSSSEETKQLIRDVYNFAKDTVKSTETPGSTPLMAILDQRLNGKEVTSRRMVQTVNQNTPAPIMPKSMKKLKFLDIDVLEFARQLTIIESRLYAKIKPTECLNKTWQKKVAEGEPEPAPNVKALILHSNQMTNWVAEMILSQTDVRKRVVVIKHFVAVADKCRQLNNFSTLTSIISALGTAPIARLKRTWDQVPQRIQTTLENMRKLMASTKNFGVYLTDLTFIEDGIPSVIKKTNLINFAKRAKTAEVIRDIQQYQNVAYSLQPVPELQDYILSNMQAAGDVHEMYDKSLQIEPREREDEKIVRVLAESGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4Z2</accession>
    <name>G0S4Z2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0032180</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693659.1">
        <property type="nucleotide sequence ID" value="XM_006693596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4Z2"/>
    <dbReference type="SMR" id="G0S4Z2"/>
    <dbReference type="GeneID" id="18257256"/>
    <dbReference type="KEGG" id="cthr:CTHT_0032180"/>
    <dbReference type="eggNOG" id="ENOG502RW27">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_532084_0_0_1"/>
    <dbReference type="OrthoDB" id="332863at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050114">
        <property type="entry name" value="UPF0173_UPF0282_UlaG_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43546:SF7">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43546">
        <property type="entry name" value="UPF0173 METAL-DEPENDENT HYDROLASE MJ1163-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="2">
        <location>
            <begin position="11"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="3">
        <location>
            <begin position="230"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS21363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="512" mass="56621" checksum="81E488BF05749014" modified="2011-10-19" version="1">MQYFQMLLGAGTATIAASDRLSFVAVSAITHFGPVSYMARVPNNADINIWEPTGNVWFKVSKINVLPSPNGGSLTSGEAIWLAYNMDKKSVELTILKSIPSGKYIVRVDSIALHQTSKSTMEYFMAQAEYDEEEEKQLREAQQEELDAEGPPSPPPSPSTKNGNAAKQPKQEQQQQQQQQQTSINSKTAAAHNTKTHPNAQPSDSQSSLQTGNIFFIGTATTLIQYHGVRILTDPNFLHAGDHVHLGPGVTAQRLTEPAIPALSALPPIDCVLLSHYHEDHFDKEVEAQLGRQVPIITTIHARSCLVEGKPEGVRFERVWGMDVWDEIVMPIVVEEEDESEKRQPAIKVTAMPGKHVPSGLLGMMNELLWAVPPTNGWMVDLGRQGGSGEQEFKTGLRIYISGDTLFVDELKDIPKWLKGEKIDIMLVHLGGTTILGPKLPLIMVTMDAEQGVKLIRLVNPDVTIPIHFDDYDTFLSPLENFKREVVAAGLADKVVYLERGEEYQFTVRNTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G0S532</accession>
    <name>G0S532_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acireductone dioxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Fe(2+)-requiring)</fullName>
            <shortName evidence="11">ARD'</shortName>
            <shortName evidence="11">Fe-ARD</shortName>
            <ecNumber evidence="11">1.13.11.54</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Ni(2+)-requiring)</fullName>
            <shortName evidence="11">ARD</shortName>
            <shortName evidence="11">Ni-ARD</shortName>
            <ecNumber evidence="11">1.13.11.53</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ADI1</name>
        <name evidence="12" type="ORF">CTHT_0023910</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:49016"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.53"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16723"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="11">Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the acireductone dioxygenase (ARD) family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.54" evidence="11"/>
    <dbReference type="EC" id="1.13.11.53" evidence="11"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692853.1">
        <property type="nucleotide sequence ID" value="XM_006692790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S532"/>
    <dbReference type="STRING" id="759272.G0S532"/>
    <dbReference type="GeneID" id="18256429"/>
    <dbReference type="KEGG" id="cthr:CTHT_0023910"/>
    <dbReference type="eggNOG" id="KOG2107">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090154_1_1_1"/>
    <dbReference type="OMA" id="WYMDESQ"/>
    <dbReference type="OrthoDB" id="1867259at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010308">
        <property type="term" value="F:acireductone dioxygenase (Ni2+-requiring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010309">
        <property type="term" value="F:acireductone dioxygenase [iron(II)-requiring] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02232">
        <property type="entry name" value="cupin_ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000079">
        <property type="entry name" value="1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03154">
        <property type="entry name" value="Salvage_MtnD_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004313">
        <property type="entry name" value="ARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027496">
        <property type="entry name" value="ARD_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418:SF0">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03079">
        <property type="entry name" value="ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="3 11" id="KW-0533">Nickel</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS20557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="169" mass="19807" checksum="F1C860A9466A04FC" modified="2011-10-19" version="1">MRAYIYDDLPGDQRLAHDSGEEVSASELNSLGVLYYKATSLDEVNALAQQRGYKNRDEIEVSPSALGESYETKVRSFFTEHLHEDEEIRYVRDGRGYFDVRDKQERWVRIAVEKDDLLILPAGIYHRFTTDESNAMRLFKEEPKWTPLNRSEELNDNPYRKEYVATYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0S555</accession>
    <name>G0S555_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Asteroid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0032290</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asteroid family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693670.1">
        <property type="nucleotide sequence ID" value="XM_006693607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S555"/>
    <dbReference type="STRING" id="759272.G0S555"/>
    <dbReference type="GeneID" id="18257267"/>
    <dbReference type="KEGG" id="cthr:CTHT_0032290"/>
    <dbReference type="eggNOG" id="ENOG502SCR2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016461_1_0_1"/>
    <dbReference type="OMA" id="GEADDWC"/>
    <dbReference type="OrthoDB" id="5297549at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026832">
        <property type="entry name" value="Asteroid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039436">
        <property type="entry name" value="Asteroid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665">
        <property type="entry name" value="ASTEROID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665:SF1">
        <property type="entry name" value="PROTEIN ASTEROID HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12813">
        <property type="entry name" value="XPG_I_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asteroid" evidence="2">
        <location>
            <begin position="147"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Asteroid" evidence="2">
        <location>
            <begin position="217"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS21374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="578" mass="64847" checksum="8C7726E385A6CFE5" modified="2011-10-19" version="1">MGIPQLKKHLEPHAERKVIEPCKAVVDGPSLAYHILGLCCRQTRRTSPFEQPTYDLLGRTAISWLNAIEECGISVIAIYFDGYLPRQKRPERVQRLLHSSRDLIKYHSAFITGVPRASSSKADDDTTVVDLFPHSWPGESRPKPPPPAFLVPAIIDALCASESYARLVYLVPGEADGFCAERARREGEPVVILTSDSDLLVHPLGDNQAARGEERGDGLSRLSFELSRDPYLTLGQAVEKCKRKGDDETLQKEYEAFVQSYLTPEIGTGFREQGLGYNEPRLDPRVSELVHQVLQRASREGQNEESDGEHYRNVEMFLPLLLDSTSRTSAWEGSRDVRRLAYAVLQLLTTRPISMVHEMRRMQRASSGTAIEVPPQAKVSELTSTLLNLMSKIQQSVGRTKVVWLVLGFFYDICLTVDRGRGFPLGLELLSQEKSGKLNETSWEFVHFLAEVQATCYSLRMLSQMLGFVASRVKKLPKQLTRLSRLLEALPSLPEFPSLGTFAEMLRSMREEGGLDCLLNVCNDARFNDILPHIDEIKRSTIRKKSPKKTKGVQMGEGRIAPRLTNPFNLLVTAGSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0S597</accession>
    <name>G0S597_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Eukaryotic translation initiation factor 2 subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0032740</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF2B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693712.1">
        <property type="nucleotide sequence ID" value="XM_006693649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S597"/>
    <dbReference type="STRING" id="759272.G0S597"/>
    <dbReference type="GeneID" id="18257312"/>
    <dbReference type="KEGG" id="cthr:CTHT_0032740"/>
    <dbReference type="eggNOG" id="KOG2916">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033458_0_1_1"/>
    <dbReference type="OMA" id="DVNEHQR"/>
    <dbReference type="OrthoDB" id="1685042at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04452">
        <property type="entry name" value="S1_IF2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1130:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000015">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.190:FF:000002">
        <property type="entry name" value="Translation initiation factor 2, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1130">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.190">
        <property type="entry name" value="Translation initiation factor 2, subunit 1, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044126">
        <property type="entry name" value="S1_IF2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024055">
        <property type="entry name" value="TIF2_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024054">
        <property type="entry name" value="TIF2_asu_middle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011488">
        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07541">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110993">
        <property type="entry name" value="eIF-2-alpha, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116742">
        <property type="entry name" value="eIF2alpha middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="17"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="294"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS21416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="310" mass="35223" checksum="E425A1165DA983DA" modified="2011-10-19" version="1">MSFTNCRFYEEKYPEVDSYVMVNVKQIADMGAYVKLLEYDNIDGMILLSELSRRRIRSIQKLIRVGRNEVVVVLRVDKEKGYIDLSKRRVSPEDVVKCEERYNKSKIVHSIMRHVAEKTQTPIERLYETIGWPLNRKYGHSLDAFKLSITNPDVWEGIEFPSEAVEQELKGYIGKRLTPQPTKVRADIEVTCFGYDGIDAIKAALRTAEAKNTPELQVKCRLVSPPLYVLTNTCLDKNAGIARLEEAIVDIRKSIEAAGGHLVVKMEPKAVTESDDAELQALMEKRERENAEVSGDESVSESDENLPEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5H7</accession>
    <name>G0S5H7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0033000</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="16 17 18" key="2">
        <citation type="journal article" date="2019" name="Mol. Cell" volume="74" first="1175" last="1188.e9">
            <title>Structural Basis of an Asymmetric Condensin ATPase Cycle.</title>
            <authorList>
                <person name="Hassler M."/>
                <person name="Shaltiel I.A."/>
                <person name="Kschonsak M."/>
                <person name="Simon B."/>
                <person name="Merkel F."/>
                <person name="Tharichen L."/>
                <person name="Bailey H.J."/>
                <person name="Macosek J."/>
                <person name="Bravo S."/>
                <person name="Metz J."/>
                <person name="Hennig J."/>
                <person name="Haering C.H."/>
            </authorList>
            <dbReference type="PubMed" id="31226277"/>
            <dbReference type="DOI" id="10.1016/j.molcel.2019.03.037"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 1-215 AND 224-1179</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
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        <text evidence="2">Belongs to the SMC family. SMC2 subfamily.</text>
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        <property type="chains" value="A=103-160, A=169-224"/>
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        <property type="resolution" value="2.00 A"/>
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    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
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    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
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        <location>
            <begin position="521"/>
            <end position="642"/>
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        </source>
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        </source>
    </evidence>
    <sequence length="1179" mass="133013" checksum="116E6D66B15FCD7B" modified="2011-10-19" version="1">MRVTELIIDGFKSYAVRTVITGWDESFNAVTGLNGSGKSNILDAICFVLGITNMSTVRAQNLQDLIYKRGQAGVTKASVTIVFDNRDKKRSPIGFEEYATISVTRQIVLGGTTKYLINGHRAQQQTVQNLFQSVQLNINNPNFLIMQGRITKVLNMKPAEILAMIEEAAGTRMFEDRKEKALKTMAKKDLKLQEITELLRDEIEPKLEKLRQEKRAFLDFQQTQNDLERLTRIVVAHDYVRCQEQLKQSASELEAKKQRAKELEESAHRLKSEISNLEEDLERVKSQRDKELRKGGKAQALEEAVKKHSNELVRLATVVDLKKGSITEEKERRAGCEKTVAELETTLKEKTKAYEKIKAKYDAAKEAAEKQRQEAEAKEELLQTLQTGVASKDGQENGYQGQLQDAKNRATAAVTEQEQAKLKIAHLEKRIKEEEPRAMKAKEQNAALLKDLEGLRQQAQRLEREMAKLGFQPGAEQELYKQEAALQQTIRDLRQEADALKRKVANIDFHYHDPVPNFDRSKVKGLVAQLFTVDKRFLQAATALEICAGGRLYNVVVDTEVTGTQLLQGGRLRKRVTIIPLNKIAAFRASAQTVATAQRICPGKVDLALSLVGYDEEVSAAMEYVFGNTLICADAETAKRVTFDPNVRMRSITLEGDAYDPSGTLSGGSAPNSSGVLITLQKLNDVTRQLREAEASLEKLQATIVREKSKLDQAKRLKQELDLKTHEIKLAEEQISGNSSSSIIHEVENMKEQIAQLKQAVVEAKQRQAEATADIKRIEKDMKDFANNKDAKLVELQTSLDKLRASLEKMNAANKTLQKELQEAQLDLEQVSGDLTAAREQLQEIDQAIKAHQEELEDLARQQRKVKEAHDVAQAQLDEERAKLHVFDDELQALEEAIRSKNARLTEEGLEKQKLGHQVEKFHKEQQAAAQRVAAMEKEYEWIAEARDQFGRPGTPYDFHGQNIAECKAMHRNLLDRSQGLRKKINPKVMNMIDSVEKKEMSLKHMMKTVLKDKHKIEETIATLDEYKRKALQETWEKVNGDFGQIFNELLPGSFAKLEPPEGKDLTDGLEVKVRLGKVWKQSLTELSGGQRSLIALSLIMALLQFKPAPMYILDEVDAALDLSHTQNIGRLIKTRFKGSQFIVVSLKDGMFQNANRIFRVRFSEGTSVVQALTPADLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5T5</accession>
    <name>G0S5T5_CHATD</name>
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        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
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                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Csf1"/>
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        <property type="entry name" value="Csf1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048636">
        <property type="entry name" value="Csf1_N"/>
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        <property type="entry name" value="PROTEIN CSF1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PROTEIN CSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25038">
        <property type="entry name" value="Csf1_C"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
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        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
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        <location>
            <begin position="30"/>
            <end position="864"/>
        </location>
    </feature>
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        <location>
            <begin position="2490"/>
            <end position="3215"/>
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        </location>
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            <end position="1250"/>
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            <begin position="203"/>
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            <end position="563"/>
        </location>
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        <location>
            <begin position="1159"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1219"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="3142"/>
            <end position="3157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21678"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF25038"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGS21497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3225" mass="358590" checksum="F9383D12B2EC3518" modified="2011-10-19" version="1">MASDGLPSSQGPMFNADFLGVLIACASLAIFSLLYFNRVFASLVSWGIRTYTWHRYQIYIDIQALQISLLAGRIFFTGLRYHGNNETILVQNGHITWAYWLRRVREVQIGKNKAARQDDDGAPADHLTKLPCRVKVSLMGLEWFIYNRSPAYDSVLAGLDKSDPVANNTRERDVQTETVPGSTLKLRKRRQDRPTKIDGATRAMSSASREKNSGSSDRPCSPVAGHPSSLRSSASETDDRERNGSDHAAQYESQLPLFLQLLPIHIECEKAALVMGNENTRAVLIIKADTLSGEVDASETKTPDPYRQYFRFKFNHPVIEMRENPDYKEDQAARAARDKHIPQGPLASPPKRSFLRWQRHGLHAGLRRLIPFLNPSVESLSSSDRDIDTATGQVPPSGQWQGLSRYLSDDTEDQRSRWASCEYAAVPTLLDSPEASLTIFWDVAGKVAPGLGEDASGRALNINGAEPPAWSITLSIHGGSINYGPWADRHRAELQRIFVPSLCKDAVPASPLPPGAFRMPTQFTFYVELTDVTTIRIPTKEESKNWRWKGKESVSKKLQSHDTRRVRRSKKSDQPADVHSRPYGWLDIKVPSNSTASYSMDMVAGPSGYTVTLEVDFPTTEITSSINHEVLWRSGRQRISCDLSTPLSWNGLRQWHFNISSNELELYLLRDHVFLLTDVVDDWATGPPTEYLVFTPFKYHLNFQLHDVKLFLNLNDANIINNPTDPEDNTYLIISSPLLRIKTCIPIDEYRPMRNTIPYDIRADTVSFDLHVPPWNTQASFLSSKEVGRLETLVIKGTYHYNATISPGNIDTLVVNVTGQSLVATFYGFTIRYFLKVKDNYFGEDIHFKTLEEYQESLRLKETDPAAELANRPPPKKSNDLDVILSVRTDDPKIILPANLYSSQRHIQIDTASLCLDLRLTNYYMDMDLVVAPLNFSLGHTGSGAETPMSSTSSTQMFIDGLHVYGHRLFGLPPTEPTYMCNWDLSAGALTGECTVEFLTTLVNAGKSFAFSFDDDENALIPASALIVYDITFFRAHVHSVRLWLHVEDAAFLLSTGTINLRYNDWARSHYSKRAVINIPDVKVSCLNAESATRHKSRSSRQVEADALVETSVRLAVITRKAHFSAERKLQQDLVRASDQRTRRTHFLILPELVADGQLPSNVEPASQSIPPMPTPLKPEELTGGDGASFISSVSSNRFQGLRSQSSFLPFSSSAQRSVRKPLSSKRSSKKELTSEQGSARFGDDGSTPWEHASLARQSLYHRTSGETVNYQDAAHNTVAFSSQYFAPYFPLEHVRPSHQDAMMQTIEDDEADLIKFELADIDPTSLDEDFAYSAVVLELPPGLNMFCNPTSLRYVAALLSSLQCLDPDNILDSLQIDSMKEIFDMQKDQTMKGRIGDFMVKLPQVNLRLVNPASLDSLDQATDEHDQYDVVLKKLSFMSRIHTTWQDPFKAASRQARNAFHLRLASIEIAATERLQGVGNPQAAASARVENVIAFGDTRDATSLYLEVDAIGASTSSGKVDSLASLIHRASLLGADLGKLFSETSSQEKMVTRNLVRHLIAKKQETPDPSFLVRPSAVLRSATQHLRTFDSWKLIMRLRQMWTVLEATEAEELLASCFTPPTISLIQAKKEVLSAFEGWRSWDLDNIEESVFVNLIFGNGVDRSASSATNKPTFVAAKIKQLQLALNPGPKQNGIILLDLAIRVQLEPSSDQHLGEGLPPSITSNIINVSCGNATVSLNWELYELAENILNLVERIDSQSLSESLPTSSDVNQTKTVAHSLSETTTHCVVVLDHGSLIIEAINLYSESFADHARASLLVKRGANNATDTNLILSCDSVSSSLRSHHQKLAKLSLEMPSVFASHELRASETTDSHTIKATASNRYMSLMVKQDPITLAEVLDLLVRDEFAQLSQLKKQLPSLLMTPAAPKNIKDRLTAFRVNVALFMDRYTITIPLLRSLTYTVHGTVSRAAIAANFGREIIFDFDIKENSHDIQIQANNVSRSISLLQIPPTSGRIRSHIDHEEHMVSVFASVELVQLDVGAVYSLLSALNRPEISSAMSELQEQIKIIEEHIKEVTGHEDLHFEKGSPRSNQSTLVYAVHLTLAGIEIFGETPLTSDTTALAHISFSLDSIHLSLANRVEQHGPTLTYPELNLNLRRISCQFKRGVAGAMTCCGNVVFGALITASSRPNEDGKEERFFHVRSDTFEADLSPATVSTAVDVLGYMNDRFKDLDTSKELEYLRRFKQSRPRIAVNNGEPGTETDIIGAFLSSITYSFEFCNIQLAWLVTDKDDILTPGSEDLVLSLARIELGTRTRNSARLAIENLQLQMVRPSHDKRLRSPNSALLPEVIFNVAYVSTADIRRLAFQAVGKPLDVRLTSGFIIPAAHLNDSINWSLQKVQQASQNWSPIVSSPPPEAVNLQSEEQLERKNFIGGKRLESLLIDADFAGAVVHLTGQKPSREWIPHHRPARPSSSGKQGHFSADETASSTTLRSPGLAFKLEFRDNGKDDPSLHAEIKIDASSNTIYPSVVPLIVEISDSIKKIVSSSDEGTERKPSLKARDVTARVKLPEEDNILATDPTTMLGRVRLNLGLRICRQEFSLSCQPIARVAATASFDSVYFIANTVRSTDQGNFFAVSGIFTHLQASVQHVYSRESTGSFKVESIVLSLLNSKHLSGTSGLSAILKVSPMEVSINAKQLQDFLLFREIWIPSNKVDPTAHPVAKLVTETSQGHLVQRYQQVAATAAFPWTASISIEALKIVVDLGQSLGKSTFSIQDFWVASKKTSDWEQNLCLGFRMIGVESTGRMSGFVALEDFKLRTWINWPEREQALNETPLIQASVGIRQLRVKAAFDYQAFLVADIRSLEFLMYNVRRSRKGSGDKLKAVFIGDAVQIFGTTTSSSQGVALYQAFKRLIQERKANFETSLKEIERYLQRKSVSAPSDVIELLKAAKSNVKDDNVVKSPISLDTDVAVTLKALNLGVFPSSFSDHQVFKMEALNAQARFAASVIDDGRIHSILGLTLGQLRIGLASVRSPASPRTLGELSVEDVVQSATGSRGGTILKVPKVEAVMQTWQRNDSKRIDYIFKSAFEGKVEVGWNYSRISYIRGMWANHTKTLAQTWGRELPNVTAIRVTGVGLSPDDEGKGKVKEKETEKQKDNKITAEVNVPVSKYEYVALEPPIIETPQLRDMGEATPPLEWIGLHREKLPNLTHQIILPHTYTLDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5W6</accession>
    <name>G0S5W6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0025180</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692978.1">
        <property type="nucleotide sequence ID" value="XM_006692915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5W6"/>
    <dbReference type="STRING" id="759272.G0S5W6"/>
    <dbReference type="GeneID" id="18256556"/>
    <dbReference type="KEGG" id="cthr:CTHT_0025180"/>
    <dbReference type="eggNOG" id="KOG4339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011525_0_0_1"/>
    <dbReference type="OMA" id="EINNFKM"/>
    <dbReference type="OrthoDB" id="5563016at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751:SF18">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR PHACTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="584"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="375"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="407"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="682"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="796" mass="84674" checksum="267F58C7F6F53473" modified="2011-10-19" version="1">MAALVQGYPQQSGTVTMLQTRPSSASGMLQTIPTQPASQHRPAGSQRQNGIHALPSSASTPAIHRGPGPIQPYAFTTTPTALNPPTQWQQVRAHRTGSSPAVPNIQALDLSRSRYAASSSMTNLPSTVNISLHTNIGSRDDSTIPARPATSPRPANPNTATQSSTPSATPPRPLPERYRRSALRPDPSVLSPATSPVAATTSGNVNDAPSLTLPDPNSLSLLRPSPPPGKNRPNSCVASARSPVDDFSVPRGQTQEEIKKIRRRSLPALDSVHLMPYDFAQSGESRRPQTADNNDNRASHAASRLIADLNGYAMELAHSDVRASRQSGESTQPSSASRNASPVPTTNNPTPTSSLPHQQTASHGAHSPVNIPPRSSSTDAASAKKTGNPSPLSKPVTMDEATAGTNAADASSSTPHTAPSPSRIESLAVRKLTDISEKSGKPRSKTSRLRRAFSFGSAAEFRKAVQGADEESKSHKARKQDGTEDEEQDRIAQQQEAAGIGSNIYGGRFFSGSTDNLSISSTASSASIMIRKMGRGMKKGTRSLVGLFRPKSLIGDKAGEAKQKDLPQTAVSMVTAEAEVERAIVHPETQQLRGALDFSRTGSSSGDTNKSPGAPDSYRPASSEVDNSFATPEPPARKTIVGDAKDRAEVLASVTPVRKGILKNRNGSSSSPRPSETKPSDSDSSSSSAPSTPSEDQQGAKRAQTIAVGNEDYFVSALRLRQEKGNTTPGQQPKRCTTFSPRIVFFETWPSQEYDRRGDIATCNRLTPMLAQQIKEELNNFKMVGILNPPDGEIWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0S610</accession>
    <name>G0S610_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative vea protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0025620</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693022.1">
        <property type="nucleotide sequence ID" value="XM_006692959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S610"/>
    <dbReference type="STRING" id="759272.G0S610"/>
    <dbReference type="GeneID" id="18256600"/>
    <dbReference type="KEGG" id="cthr:CTHT_0025620"/>
    <dbReference type="eggNOG" id="ENOG502RYR6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022491_1_1_1"/>
    <dbReference type="OMA" id="SNDKPEY"/>
    <dbReference type="OrthoDB" id="3056235at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF17">
        <property type="entry name" value="SEXUAL DEVELOPMENT REGULATOR VELC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="7">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="212"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="240"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS20726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="262" mass="29147" checksum="5A89EB4B06B198EA" modified="2011-10-19" version="1">MADFLPLSSLEVPQAHNPALLRDRKQNARIPHHRPPTALAARSCGFGERDRRVIDPPPIVQLVLADTPTTATLTPEERSRWLRHQFSVVHCSIWDETGTRDMSSMPEDFRQQRRLMGTLVASPFVGLDDKGEEGCFFCFPDLSCRTPGTFRLKFALVMIDPTRMHVGHRSAIVATVMSEPFQVFNAKDFPGMQASTPLTKRLKEQGCLISIKKGNEKRDGKNGSGGDSASGGKGPNKREEDDDDDDDEGSGCEERASKRLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0S621</accession>
    <name>G0S621_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Vacuolar ATP synthase subunit d-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0033890</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693825.1">
        <property type="nucleotide sequence ID" value="XM_006693762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S621"/>
    <dbReference type="STRING" id="759272.G0S621"/>
    <dbReference type="GeneID" id="18257427"/>
    <dbReference type="KEGG" id="cthr:CTHT_0033890"/>
    <dbReference type="eggNOG" id="KOG1647">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069688_0_1_1"/>
    <dbReference type="OMA" id="EMIEPAN"/>
    <dbReference type="OrthoDB" id="7676488at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="V-TYPE ATP SYNTHASE SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="131"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS21529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="179" mass="19655" checksum="3E86328CB4EF196A" modified="2011-10-19" version="1">MSGAASLGVMKAKLKGAETGHSLLKRKSEALTKRFREITRRIDEAKRKMGRVMQIASLSLAEVTYAAGGNIGYQIQESAKSARFRIRTKQENVSGVLLPTFEVYIAEGSNDFAMTGLGKGGQQVQRQCHVANKKQRDTTALDEELKKKTDQNREAAGSEQPPAEPADLLKSVEDEDVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0S662</accession>
    <name>G0S662_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0034310</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693866.1">
        <property type="nucleotide sequence ID" value="XM_006693803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S662"/>
    <dbReference type="STRING" id="759272.G0S662"/>
    <dbReference type="GeneID" id="18257469"/>
    <dbReference type="KEGG" id="cthr:CTHT_0034310"/>
    <dbReference type="eggNOG" id="ENOG502SERQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038857_1_0_1"/>
    <dbReference type="OMA" id="YQRIPGF"/>
    <dbReference type="OrthoDB" id="2896006at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS21570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="373" mass="40451" checksum="5F531C06F7F8729E" modified="2011-10-19" version="1">MIPSVTAAGALMKRFAAQGLDLSPERRIPPYAGFVFFADFLIFLPASLMIGYTFQHVYPTLAAVEDPDLASYEFLPVNDVNDKAAVGSNKKQPNPVAEAKSSPSAHSSSPQAVTSSIRQTARLLRSLTGWPSFLRGLGYGLLSGFAFLTLWRLLALVLPFDHLLAYPLALIATAPLHAAWTHSMVAVPSHRSFFSRIPSLRSAYRATWLPVLLFSVLSCLSTAVPDMLISLVAGPDTLNVLMRPSSATTPASPPEMSPYTALKLLVIVVLSVLLKFVLVIPAHVALVRVQTTLLPADEDTIVRFDRSFGGRVESVAVCSKCGFALLRAALASVTFQSWRRIVLLRVKLFALAIAMYLAMGAILGVQVMLMRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6E3</accession>
    <name>G0S6E3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase</fullName>
            <ecNumber evidence="4">4.1.3.44</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">tRNA wybutosine-synthesizing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CTHT_0034610</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:36347"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10165"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="EC" id="4.1.3.44"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TYW1 family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.44" evidence="4"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693894.1">
        <property type="nucleotide sequence ID" value="XM_006693831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6E3"/>
    <dbReference type="STRING" id="759272.G0S6E3"/>
    <dbReference type="GeneID" id="18257499"/>
    <dbReference type="KEGG" id="cthr:CTHT_0034610"/>
    <dbReference type="eggNOG" id="KOG1160">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007952_1_0_1"/>
    <dbReference type="OMA" id="FHVNGKW"/>
    <dbReference type="OrthoDB" id="271553at2759"/>
    <dbReference type="UniPathway" id="UPA00375"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102521">
        <property type="term" value="F:tRNA-4-demethylwyosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000196">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013917">
        <property type="entry name" value="tRNA_wybutosine-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034556">
        <property type="entry name" value="tRNA_wybutosine-synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930:SF0">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE TYW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08608">
        <property type="entry name" value="Wyosine_form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00284">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01071">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Flavodoxin-like" evidence="18">
        <location>
            <begin position="327"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="19">
        <location>
            <begin position="655"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="279"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="507"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="969"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="299"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="974"/>
            <end position="991"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00071388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00077859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGS21598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="991" mass="110403" checksum="E13411F1B3A0FF2D" modified="2011-10-19" version="1">MSTDHPLSDRGRAPTAVISSSPPPSQPHNQALKKRTAQSRLQYQMNSSPPLAGRDSEESRPFIGNQYGTHHDEFRQRQSETFLSSSGRVSWTYRNQWILLAISSGACAAFNGVFAKLTTTELTATLSKSVARGLGFESIEGWIELIVRAIFFALNLAFNGVMWTLFTAALAKGNSTTQVSIMNTSSNFVITAILGSVIFSEALPPLWWVGAALLVAGNVIVGRKDEGGPKNLDRDQSLTASVLTSAGDGEMGPSSGGARNKLTPQVEMDEDEDIIDLRSLDGRPQTQKQTEKHEQQKQGPKRIRGVPTKKGHGSPDPEVKTRRKIQVLVFFSSLTASTDKAARLFTQQLGKLLLCQASDKSDSWFLEPKVLDLAEIDYDEYFITPPKSDGADVDFFYLLLIPSYNIDSINDNFLEHLKETHHDFRIDTSPLSPILGYSVFGFGDSEGWPTEEEGFCFQAREVDKWMAKLSGRKRAFPLGMGDWKRDAKDRLAEWQSGVVDVLRQLEQTGSLGEGVPGSGDPIESDDEREVGDDDEVFIEDGPELNSSSKSRGSDSLEDVEDIGRILELSQVDGSSGKKQGSKVPLAIDFTTEGKSSGTKKLATTVKEMVPKNSPTYTALTKQGYSIVGSHSGVKICRWTKSALRGRGSCYKFSFYGINSHQCMETTPSLSCSNKCIFCWRHGTNPVGTSWRWVVDPPDLIFNGVKEQHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLRLLHAERISSFLVCNAQHPDQLAALQHVTQLYVSIDASNRESLRRIDRPLHRDFWERFQRCLDILRERRFQQRTVFRLTLVKGFNIEDEVEGYADLVERGLPCFVEVKGVTYCGTSTSSSAGLTMANVPFYQEVCDFVVTLEKALRKRGLAYGIAAEHAHSCCILLASERFKVNGKWHTLIDYDKFFQLLEEKGPDGDFSPEDYMGPPTPEWALWGNGGFDPRDQRVDKKGRPIEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6X4</accession>
    <name>G0S6X4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0027200</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693178.1">
        <property type="nucleotide sequence ID" value="XM_006693115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6X4"/>
    <dbReference type="STRING" id="759272.G0S6X4"/>
    <dbReference type="GeneID" id="18256758"/>
    <dbReference type="KEGG" id="cthr:CTHT_0027200"/>
    <dbReference type="eggNOG" id="KOG1965">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005912_5_2_1"/>
    <dbReference type="OMA" id="FTYVRRF"/>
    <dbReference type="OrthoDB" id="196264at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF187">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0915">Sodium</keyword>
    <keyword evidence="8 9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="354"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="12">
        <location>
            <begin position="47"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="483"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="591"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS20882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="669" mass="71679" checksum="A6444A943992F0EC" modified="2011-10-19" version="1">MLAQTLFSSLLELAKRDEEDPDASDPPKQENNASWAIFILIVLLIVAFCTSYIMQQRKITAIHETVVSIFGGMIVGLGLRISGFDSIRDLVNFNYQYFFNLLLPPIILSSGYELHQGNFFRNIGTILTFAFAGTFISAVVIGVLLWIYTAISPEGLDVSWIDAISVGATLSATDPVTILAIFNTFKVDPKLYTIIFGESILNDAVAIVIFESAQSAGTKGGGIGIFSMLHGIWYFLSEFFGSLSIGAIVGVATALGLKYTYVRRYPGIETCLVVLIAYATYFFAQAISMSGIVALLFCGITLKHYAYFNMSRRTQLATKYIFQVLAQLSENFIFIYLGLALFTEKNLVYQPLLIIVTVLAVCAARWVAVFPLSRAINWFIRYRARRRGMEAGDELPYSYQVMLFWAGLRGAVGVALSALFTAKETQALQATVLVVVVLTVIIFGGTTARMLEILGIRTGVADDNDSDDEFDIEAIGGGGVYKRTDTGVGYTPHTGRGGAALPLNNVGPSGSASGDRRGRNGWASGHHSPNAGSRSRKSPRLGASHNEYERTDLLGPTSSTGGSSVESDFGSDIDISDLPPPANNSRTRSIPSPLLGPSSAATPSSGTQAAGGSSTTGQQPLTATAAIRQLLSAENPTALLRQLDEEVIKPKLLLDAGSGRGGPGGSGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6Y2</accession>
    <name>G0S6Y2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative cell division control protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0027280</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2018" name="Nat. Struct. Mol. Biol." volume="25" first="616" last="622">
            <title>Structure of the Cdc48 ATPase with its ubiquitin-binding cofactor Ufd1-Npl4.</title>
            <authorList>
                <person name="Bodnar N.O."/>
                <person name="Kim K.H."/>
                <person name="Ji Z."/>
                <person name="Wales T.E."/>
                <person name="Svetlov V."/>
                <person name="Nudler E."/>
                <person name="Engen J.R."/>
                <person name="Walz T."/>
                <person name="Rapoport T.A."/>
            </authorList>
            <dbReference type="PubMed" id="29967539"/>
            <dbReference type="DOI" id="10.1038/s41594-018-0085-x"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (4.30 ANGSTROMS) IN COMPLEX WITH MG(2+)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693186.1">
        <property type="nucleotide sequence ID" value="XM_006693123.1"/>
    </dbReference>
    <dbReference type="PDB" id="6CHS">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.30 A"/>
        <property type="chains" value="D/E/F/H/I/J=1-819"/>
    </dbReference>
    <dbReference type="PDBsum" id="6CHS"/>
    <dbReference type="AlphaFoldDB" id="G0S6Y2"/>
    <dbReference type="EMDB" id="EMD-7476"/>
    <dbReference type="SMR" id="G0S6Y2"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:mitochondrial outer membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:nuclear protein quality control by the ubiquitin-proteasome system"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
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    <dbReference type="CDD" id="cd19519">
        <property type="entry name" value="RecA-like_CDC48_r1-like"/>
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    </dbReference>
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        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
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        <property type="entry name" value="ATPase_AAA_core"/>
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        <property type="entry name" value="ATPase_AAA_CS"/>
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        <property type="entry name" value="Cdc48_dom2"/>
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        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
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        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
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        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="10" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="7">
        <location>
            <begin position="41"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48" evidence="6">
        <location>
            <begin position="141"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="253"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="527"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="727"/>
            <end position="747"/>
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    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="787"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="737"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="793"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="542"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="594"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022741"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS20890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="6CHS"/>
        </source>
    </evidence>
    <sequence length="819" mass="90317" checksum="4BB0D06C481AF8D6" modified="2011-10-19" version="1">MAPESKDHKKKVNLTDPSGAEHREENDTATAILKKKKKPNQLMVTDAVNDDNSIIALSNNTMEALQLFRGDTVLVRGKKRRDTVLIVLADDDLDDGSARINRVVRHNLRVKHGDMITIHPCPDIKYAKRIAVLPIADTVEGLTGSLFDVFLAPYFREAYRPVRQGDLFTVRGGMRQVEFKVVEVDPPEYGIVAQDTIIHCEGEPIPREEEENNLNEVGYDDIGGCRKQLAQIREMVELPLRHPQLFKSIGIKPPRGVLLYGPPGTGKTLMARAVANETGAFFFLINGPEIMSKMAGESESNLRKAFEEAEKNSPAIIFIDEIDSIAPKREKTNGEVERRVVSQLLTLMDGMKARSNVVVMAATNRPNSIDPALRRFGRFDREVDIGIPDPTGRLEILQIHTKNMKLADDVDLEQIAAETHGYVGSDLAALCSEAAMQQIREKMDLIDLDEDTIDAEVLDSLGVTMDNFRYALGVSNPSALREVAVVEVPNVRWEDIGGLEQVKQELKEQVQYPVDHPEKFLKFGLSPSRGVLFYGPPGTGKTMLAKAVANECAANFISVKGPELLSMWFGESESNIRDIFDKARAAAPCVVFLDELDSIAKARGGSIGDAGGASDRVVNQLLTEMDGMTSKKNVFVIGATNRPEQLDPALCRPGRLDQLIYVPLPDEAGRLSILKAQLRKTPVSKDVDLAYIASKTHGFSGADLAFITQRAVKLAIKESIAAEIERQKAREAAGEDVNMEDDEDPVPELTKRHFEEAMRDARRSVSDVEIRRYEAFAQQMKNAGPGAFFKFPDSTTDNSASNAAGNSFGDAGNDDDLYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7F8</accession>
    <name>G0S7F8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription elongation factor 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0027990</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ELOF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693256.1">
        <property type="nucleotide sequence ID" value="XM_006693193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7F8"/>
    <dbReference type="STRING" id="759272.G0S7F8"/>
    <dbReference type="GeneID" id="18256837"/>
    <dbReference type="KEGG" id="cthr:CTHT_0027990"/>
    <dbReference type="eggNOG" id="KOG3214">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105983_3_0_1"/>
    <dbReference type="OMA" id="CVECRID"/>
    <dbReference type="OrthoDB" id="445983at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007808">
        <property type="entry name" value="Elf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038567">
        <property type="entry name" value="T_Elf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934:SF0">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05129">
        <property type="entry name" value="Zn_ribbon_Elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="53"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS20960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="93" mass="10095" checksum="7728ADFD75FD1129" modified="2011-10-19" version="1">MCLFCNHERSIEIKLDKKVGVGNLEYLSAPIDVYSEWVDAAEAVAQEAAAEAMAEKLSGGRGGGSSRRVHDDDDDERGGYEGEGIVPDDEDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7L1</accession>
    <name>G0S7L1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CoA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0036710</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694098.1">
        <property type="nucleotide sequence ID" value="XM_006694035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7L1"/>
    <dbReference type="GeneID" id="18257709"/>
    <dbReference type="KEGG" id="cthr:CTHT_0036710"/>
    <dbReference type="eggNOG" id="ENOG502S3ZG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112567_1_1_1"/>
    <dbReference type="OMA" id="GHRIFAW"/>
    <dbReference type="OrthoDB" id="5138418at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33303:SF2">
        <property type="entry name" value="COA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33303">
        <property type="entry name" value="CYTOPLASMIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA-binding" evidence="1">
        <location>
            <begin position="16"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="135" mass="14256" checksum="064D53716F28B324" modified="2011-10-19" version="1">MAASDATLRAFFQSAKFAVVGASTNTEKFGYKGAKAIEVDGKEYPTVASLSELPNPQETSVSIITPPRVTLKTLEEAKSLGIQSVFLQPGTFDDEVLKYANQNFKTVLAGNGGAGPEGWCVLVDGDRGLRSAGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7Y4</accession>
    <name>G0S7Y4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell surface protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0037440</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694167.1">
        <property type="nucleotide sequence ID" value="XM_006694104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7Y4"/>
    <dbReference type="GeneID" id="18257782"/>
    <dbReference type="KEGG" id="cthr:CTHT_0037440"/>
    <dbReference type="eggNOG" id="ENOG502SM0P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047729_4_0_1"/>
    <dbReference type="OMA" id="CVMRVRN"/>
    <dbReference type="OrthoDB" id="5310497at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021476">
        <property type="entry name" value="Egh16-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618:SF1">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618">
        <property type="entry name" value="SURFACE PROTEIN MAS1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11327">
        <property type="entry name" value="Egh16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409378" description="Cell surface protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="33006" checksum="E256364303435531" modified="2011-10-19" version="1">MHISALCALISLVGPSAAHGVVTLIRGANGVDMPGLSIIDGTPRTCSTNRCGSQADTAIIRDREIRSGRVGPLGRTQGSGPVDAAVMIARFMGTSTGATTLRTNTSLEFDDPAEDPIDVSRLSRLADAGRERGGRNNQKRGMLMVARQFLSRLREGLGRGGTASTEEVERNVAALAGLGATAGLPTCADDGTIEMVFHQVNQDGAGPLEAMVDGTSGGTDLAAFKPARVIQDVPGFGFQGLSLATSRDFPLRVQMPEGMTCDATVAGVSNVCIVRVRNNAAAGPFGGSAAFTQSPAARKRAIEYRMKMRRAVEFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7Z0</accession>
    <name>G0S7Z0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mannitol-1-phosphate 5-dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0037500</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NAD(H)-dependent interconversion of D-fructose 6-phosphate and D-mannitol 1-phosphate in the mannitol metabolic pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-mannitol 1-phosphate + NAD(+) = beta-D-fructose 6-phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19661"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:61381"/>
            <dbReference type="EC" id="1.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mannitol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.17" evidence="4"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694173.1">
        <property type="nucleotide sequence ID" value="XM_006694110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7Z0"/>
    <dbReference type="STRING" id="759272.G0S7Z0"/>
    <dbReference type="GeneID" id="18257788"/>
    <dbReference type="KEGG" id="cthr:CTHT_0037500"/>
    <dbReference type="eggNOG" id="ENOG502QVPN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036089_0_1_1"/>
    <dbReference type="OMA" id="APFIERK"/>
    <dbReference type="OrthoDB" id="418169at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008926">
        <property type="term" value="F:mannitol-1-phosphate 5-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019592">
        <property type="term" value="P:mannitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00196">
        <property type="entry name" value="Mannitol_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023028">
        <property type="entry name" value="Mannitol_1_phos_5_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000669">
        <property type="entry name" value="Mannitol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013118">
        <property type="entry name" value="Mannitol_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013131">
        <property type="entry name" value="Mannitol_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002652">
        <property type="entry name" value="PRK02318.2-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30524:SF0">
        <property type="entry name" value="ALTRONATE OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30524">
        <property type="entry name" value="MANNITOL-1-PHOSPHATE 5-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01232">
        <property type="entry name" value="Mannitol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08125">
        <property type="entry name" value="Mannitol_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00084">
        <property type="entry name" value="MTLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannitol dehydrogenase N-terminal" evidence="9">
        <location>
            <begin position="8"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Mannitol dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="212"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS21877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="397" mass="44283" checksum="393B35F41994A8D9" modified="2011-10-19" version="1">MKRNCPKKAIHFGAGNIGRGFVACFLHNSGYEVIFAEVNEKTVARLNGQKSYRVIEVGAEGTTESTITNYRAINSRTHEDELVQEIATADLVTCSVGPHILKHIAPVIAKGIDKRSTDLTPVAVIACENAIGATDILADFIKSPENTSPERLADYDMRARFANSAIDRIVPAQDPDAGLDVKLEKFFEWVIDCTPFADHAAPDIKGVKWVTNLQPYIERKLYTVNTGHATAAYYGHVRRKTTVYDALQDREIQDEVRKVLDETAELIIQKHGISRAEQDVYVAKIIRRISNPHLEDSVERVGRAPLRKLGRKERFIGPAAELAERGEDVNALLRAAEMAFRFQRVEGDSESFELAVIMEHNTAEEVVKTVCGLEPKDKLFPAVVDVVKRVQADTHRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8C2</accession>
    <name>G0S8C2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dynactin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0021220</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="13">Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3. The 4 DCNT2 (via N-terminus) bind the ACTR1A filament and act as molecular rulers to determine the length. The pointed end is important for binding dynein-dynactin cargo adapters. Consists of 4 subunits: ACTR10, DCNT4, DCTN5 and DCTN6. The barbed end is composed of a CAPZA1:CAPZB heterodimers, which binds ACTR1A/ACTB filament and dynactin and stabilizes dynactin. Interacts with ATP7B, but not ATP7A, in a copper-dependent manner. Interacts with ANK2; this interaction is required for localization at costameres. Interacts with N4BP2L1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Stress fiber</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Myofibril</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the dynactin subunit 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692593.1">
        <property type="nucleotide sequence ID" value="XM_006692530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8C2"/>
    <dbReference type="STRING" id="759272.G0S8C2"/>
    <dbReference type="GeneID" id="18256160"/>
    <dbReference type="KEGG" id="cthr:CTHT_0021220"/>
    <dbReference type="eggNOG" id="KOG3896">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034750_0_0_1"/>
    <dbReference type="OMA" id="CGYCMWT"/>
    <dbReference type="OrthoDB" id="283815at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008603">
        <property type="entry name" value="DCTN4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034">
        <property type="entry name" value="DYNACTIN P62 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034:SF2">
        <property type="entry name" value="DYNACTIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05502">
        <property type="entry name" value="Dynactin_p62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="150"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="511"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="424"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="522"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS20297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="552" mass="60249" checksum="874DEB44260AE558" modified="2011-10-19" version="1">MATFTPYTYFQCPCSESSPITRHHHHNDRHYRRHRHTRNASVTSIVSADDDDDDDKTFDPRATRSNFSLYPLEYLLCTRSCFTCPICVGPLSVTSLETKPDPNLLSAPPSDSAPTSGPYALVCSYCLWSSTELGIKFDKPNSISSQLHKLRNGGATRLTPKERKERRKDPGYKPILVQGEDPLDPESHFAALKTFYQSQLSDPNSDSSGFGTSSSLGELGFSSSASLSRIMSLYTGGLLADKKAKNRVGAMREAITPDEGLQLCQLDETAQIARLKKVGWEGTASNGQMAEQMPAVTAGEVQMYGRGRHIISKPEAKVQTTRFRIRLVATNYVPSISIRRLNPSQTGAGSSSGGGSLSSLGDFLEPVKPAHFILTFKNPLFDAVKVTLATPAITPGRFASRVTVLCPEFEIDANTDVWDEALKDGSNKRDSKELRRPKTAAEESAAAAAGGGLQLEVGKIWERGRNWVSIVVEVVPASLRQPVDGGRVGPIREDEDVVEVPMFVRVEWETEAGGDDEIPGAGKKEGEGGKEGKEKRELAYWVVLGVGRIKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8F3</accession>
    <name>G0S8F3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL29m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">54S ribosomal protein L4, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0029680</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693423.1">
        <property type="nucleotide sequence ID" value="XM_006693360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8F3"/>
    <dbReference type="STRING" id="759272.G0S8F3"/>
    <dbReference type="GeneID" id="18257006"/>
    <dbReference type="KEGG" id="cthr:CTHT_0029680"/>
    <dbReference type="eggNOG" id="KOG3331">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063281_1_1_1"/>
    <dbReference type="OMA" id="YAHGRAW"/>
    <dbReference type="OrthoDB" id="270763at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038340">
        <property type="entry name" value="MRP-L47_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010729">
        <property type="entry name" value="Ribosomal_uL29_mit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183:SF18">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183">
        <property type="entry name" value="RIBOSOMAL PROTEIN L47, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06984">
        <property type="entry name" value="MRP-L47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="218"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS21127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="281" mass="31564" checksum="D99DB79DD37C59FD" modified="2011-10-19" version="1">MASSAAIRPAMGALGRISSTTTTAATAAVTPRQTLSALLPHQQIASISTTAVLLKRHKYPGARDNRDYSKKRGESAIRRTGTRWRLSMSDEPLPRPVSKEALPPIETDPNHGLWEFFYDRKKIVQTPEQDAAHGRAWTVEELRHKSWEDLHKLWWVCVKERNRIATANWERRKQKLGFGEAEAEARDRTVRSTMRAIKHVLTERFYLWEDARKLAENDPEVDLSGNGPAFTPRQYLESEEPAEGEPQAAEGQAEKAAVEAAVDPAMITTSASQSQQAETRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8K7</accession>
    <name>G0S8K7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tetracycline:hydrogen antiporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0038430</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694263.1">
        <property type="nucleotide sequence ID" value="XM_006694200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8K7"/>
    <dbReference type="GeneID" id="18257881"/>
    <dbReference type="KEGG" id="cthr:CTHT_0038430"/>
    <dbReference type="eggNOG" id="KOG2615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_54_5_1"/>
    <dbReference type="OMA" id="PIAYVMV"/>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF2">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
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            <begin position="20"/>
            <end position="43"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="480"/>
            <end position="498"/>
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            <begin position="24"/>
            <end position="503"/>
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            <dbReference type="ARBA" id="ARBA00004141"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="EMBL" id="EGS21967.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="510" mass="55649" checksum="1DB2BF5211B3329B" modified="2011-10-19" version="1">MPSRRGSGRAYRRVCNPDEFPTVQLLLLAIVRLAEPIALTSIFPYAFPLVKRLNVGNEEDASFYAGLVISAFSFFEALMGMYWGAVSDRVGRKPVLLLGCMGTMFSMLLVGLANNIWVALLGRAIGGFLNGNIGVIQTMVGELVIKPEHEPKAYSIMPFVWSLGTIIGPMIGGLFADPHDSWPKLFPSGSLFARFPYLLPNLICAGLLAVSILLGYFLLDETHPDKQPRVLLPDDTYLSENTPLLETSDALKRPAVDLRDENYGSVRERITPIPPAPKVDDDMVPTIWTKRIMAIIISLSIFTYHSMTFDHLLPIFLEDPRSHASTTAYSGSLFFAGGLGLSLHTVGLIMAVQGFIALFTQAVIFPLAASYFGIYQLFILVTVFHPVVYLSVPPLALIPAESTFLLHTAIYAMLVLRNLLGILLYPLLLILLKDATPSSNVLGKVNGLAASAGAACRMVAPPVAGMLYAMGKKSGCTPLAWWASALVALVGSVQCFWVPRERRETEKEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8S8</accession>
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        <recommendedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
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        <name evidence="2" type="ORF">CTHT_0040200</name>
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        <name type="synonym">Thermochaetoides thermophila</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988042">
        <property type="protein sequence ID" value="EGS20281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_006694367.1"/>
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    <dbReference type="STRING" id="759272.G0S8S8"/>
    <dbReference type="GeneID" id="18258058"/>
    <dbReference type="KEGG" id="cthr:CTHT_0040200"/>
    <dbReference type="eggNOG" id="ENOG502RS9D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1578339_0_0_1"/>
    <dbReference type="OMA" id="DAYIDAC"/>
    <dbReference type="OrthoDB" id="3499003at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20281.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="169" mass="17631" checksum="461653E10E607C5D" modified="2011-10-19" version="1">MTDSASDSVDDNEHGLAKSPVIKLCAQDSKPSRPDLDPKTASADTATVTATISVTPASTATIQCPQVNGTLYTDSRGGKRFRRVCGIDYSGEGEAVDIGNVKVGSLDAYIDACASTADCTGAGWGIIDGDTGPLHTCWMKTNLTKHHEARPDWGFAVLLANNGTTVGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8V7</accession>
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        <recommendedName>
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        <alternativeName>
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        </alternativeName>
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        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
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                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
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            <dbReference type="PubMed" id="21784248"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
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            <location evidence="2">Telomere</location>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Rap1_C"/>
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        <property type="entry name" value="TE2IP/Rap1"/>
    </dbReference>
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        <property type="entry name" value="TERF2IP_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16466">
        <property type="entry name" value="TELOMERE REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08914">
        <property type="entry name" value="Myb_Rap1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11626">
        <property type="entry name" value="Rap1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0779">Telomere</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
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            <end position="93"/>
        </location>
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        </location>
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        <location>
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        <location>
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        <location>
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        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1122"/>
            <end position="1138"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010467"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00017805"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032471"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGS19868.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1313" mass="149128" checksum="1219849E3C2FD99C" modified="2011-10-19" version="1">MAAHIAYELEDGEVHGTLFKGMKFWVAQRVPIRNDILKMIKDNGGEVVRLEKQADILIADHARKDAPEGSVSWKFVTESIQQGQRLNKDSYIIQHGASTLASASDAQPSRVRGKTAPRKHARNPFTKDDDRILAAWVLNHALQDRISGNEVYKKLDQEYPNSGHTWQSWRDRWVKRLAYYSKKEIQALAREAPEGWRKQVQRAQGRGAPTRVTPIREQQATASQTTASQQDVSESSSSEAEGPSPHATPPRERQDNQMRSTSSPGLASPKRNHFTAQEDEMLVAYVKECENEGLHIYGNKIYQTFAEKHPQHTWQAWRTRWYKHLSGHQPGTRRVKGKEPVTQDSDEEGEEVEGQAEAEREEPRSSAVSRESSSEKAKGKQPARKDSEKKEGEVDRKVEPEENHKPSSVSHQPGANKGKGKRIVSQDSGSEDNAVPGEGESEHEDFESAHEARERRFAELERKKQELLARKQVREHERQLQQHQLGEEAGADEEAVLHYTQEEAADSSEEEYSAREQSQQEGETQDGYEGPSPDLGEKGEDHDAGETSALELPRAEDEVEDAEVRASTREPSPSEDERETQDDESLPIEETLLQPASAQSRQSSQAASSCSQPRPTSRPIQEAPPNLNIDRKVFWYAFNQFRNIAFGPSARRSFWAQIGRHTVDYYNLWVAVTKEDHHASRNWWKICEDLGLNWIEDRDLPDKVKEVYERELMQLEAAIKEYSVEELRMEAEEEELGQRMGGSESDEEDEEYEQDTEGIEPDSEADMSADEKEEVVIEGVESKSEEEEDVWEEAEEEPTPTRARHLRTLHIAPSPPAPSTKRTFSKMGGSSSLSARKRRRYDRDEEIPETQFRPNDRPSSPEIQETPPHKTAASSYRQGSKNTQKGSQLFSRTNVDSKSADASQYFSAPTQENGSECAEPGTQYYSFPRNENGLVQDGDNLLQDDDDDWLAPSRQLLSELGEHAPDGSPDRPLLSIEAVDPQFEPEEKQPDEDEDDEDDEEDEDEEAFETLPRYSSTTQRKQTAAAGLVTHRAPVEPRYNPQYSRLDEGKGKESAFASFSPSPPLPREEDEEDDEVDDDDYEDAFEALPKQHPAFQHKQVATNRLSTHRAQPLPARLDKGQSKQTVLSSSPPTFPLSHSSYPHQNPFTPIPNRFPLSSALPQNHGTIPRRPSYPPPPDSPSSNAAANLEAFESIIKYYTSLGHRPSDISRALRATSLRHVPHFPSVLSHLEQYGRVEMEIPEVWTEREDEILRGVMKYLQKLKGKMPRWEDGAAWCGGDAELCRGFWRVVERWKWKGVRERVRFLEDWEMAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9N3</accession>
    <name>G0S9N3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-arabinose 1-dehydrogenase [NAD(P)+]-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0046510</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695029.1">
        <property type="nucleotide sequence ID" value="XM_006694966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9N3"/>
    <dbReference type="STRING" id="759272.G0S9N3"/>
    <dbReference type="GeneID" id="18258689"/>
    <dbReference type="KEGG" id="cthr:CTHT_0046510"/>
    <dbReference type="eggNOG" id="KOG1576">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_7_0_1"/>
    <dbReference type="OMA" id="FPRSSYK"/>
    <dbReference type="OrthoDB" id="5286008at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045290">
        <property type="term" value="F:D-arabinose 1-dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070485">
        <property type="term" value="P:dehydro-D-arabinono-1,4-lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686:SF1">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="24"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS20144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="438" mass="47254" checksum="F58A1D7EC900F19B" modified="2011-10-19" version="1">MASTTASSPGRAPRPPLNTVLPPLLLGTATFNTQYVANPHAMPYRDIVARAIALGVTGFDTSPYYGPSELLLGEALHALMNPTPTPSNPNPTPLQRSDFFLVTKAGRIAATEFDYSPSWIRYSVLRSLQRLHVPYLDLVYTHDCEFVTPGEVLAAVKELRRLRDEEGVVRYVGISGFPVNVLCDLAEMIYKETGEPLDAVLSYGHLTVQNRRLGLPFVEGGGKGQADVEGSPLVRLKKAGVDVVLNASMLGMGLLTSKGIPVTDDTGSPLAKWHPSPPELRLACMKLAELAAAAGERLESVSLRWSLAEWARVAAEAGVGVDFTSPGSSEGRKIGVAVCGVSSTPELEETVAEWRGAVSSLGQEEDGSNDKYGPARQKKVLSLVREQLWPALGSWLDYAWDSPGEGFVNTRKDSNRGVVPDDGVIAAYEKAKRSRQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9Q1</accession>
    <name>G0S9Q1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0046690</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="2"/>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695047.1">
        <property type="nucleotide sequence ID" value="XM_006694984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9Q1"/>
    <dbReference type="STRING" id="759272.G0S9Q1"/>
    <dbReference type="GeneID" id="18258707"/>
    <dbReference type="KEGG" id="cthr:CTHT_0046690"/>
    <dbReference type="eggNOG" id="KOG1906">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013572_2_0_1"/>
    <dbReference type="OMA" id="IPEHHLG"/>
    <dbReference type="OrthoDB" id="273917at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043634">
        <property type="term" value="P:polyadenylation-dependent ncRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045862">
        <property type="entry name" value="Trf4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092:SF15">
        <property type="entry name" value="INACTIVE NON-CANONICAL POLY(A) RNA POLYMERASE PROTEIN TRF4-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092">
        <property type="entry name" value="POLY(A) RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="7">
        <location>
            <begin position="469"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="6">
        <location>
            <begin position="669"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="214"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="301"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="790"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="137"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="240"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="822"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS20162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="836" mass="94666" checksum="3A3F0583283B78CE" modified="2011-10-19" version="1">MTRNHNLHSDHRSYHDRGRGHDRYHRTNRGPRSRSPPRDRDREYAREHLRDPYRPQSQSYGDRNSRDGRDGRNGRDGRDDYDTFRARGQGSPTSTAFSGRGGDDRYRPPQGDFTFRVDKPAGVQESDTYRPQNNSGRNDRRRGYSPNRDAKRNRGAQNRRDHHSSQPFGARPRRPMFIAAERELLKVNHETGNEQLLYDPSNSVQYRPLDELTDSEAESNLSNEDQQDGEPAHKRARLSLEQSASDNNVPKWSNPDPYTALPIQPIEQKKKKDVVQLIRKARIQPDQPRASLPADLADFIALDDDDEDEQENTKTTEEYDDDYEPTLDLGPSVVNVPSPAPNQGSHIAPGPADQSPVFADLSKQTTASMPATASGTAVVEDVPVENPQRVVRPRLPRGVLFEDPTPAILGNRKRTWDDEIKVPHATLKKASKIPASGEIVEAWRPRADLNPIPWFRPNATNSGSINVLLHKEVADFYAYVKPRDFEDRLRGELVQDLKRFSRRLFGDAEVYPFGSFCSGLYLPNGDMDLVLMSDLYKNGGPPRYHDNHALFKFRNGLVKEGMIHNNNIELILHARVPLVKFVERKTGLRIDISFENRSGIVAINTFHKWRNLYPGMPALVSVIKHFLLMRGLNEPVNGGIGSFSVTCLVVSMLQMMPEVQSGNMDTRHHLGELLLRFFDYYGNRFNYEGLAISLDPPALIPKNQAPPKPQPGQRKFCIIDPNDPTNDIAGGSSNAPRIVELFAEAYKELTRRLDQVAKDPNLANVSILEVILGGNYSDYERQRHYLQHLANGGEPYFPPSRPANSGNGYQHRNNGGGYQGHNHGRSRNHGSSRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9R7</accession>
    <name>G0S9R7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Beta-xylanase</fullName>
            <ecNumber evidence="8">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0046900</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="8"/>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695063.1">
        <property type="nucleotide sequence ID" value="XM_006695000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9R7"/>
    <dbReference type="STRING" id="759272.G0S9R7"/>
    <dbReference type="GeneID" id="18258728"/>
    <dbReference type="KEGG" id="cthr:CTHT_0046900"/>
    <dbReference type="eggNOG" id="ENOG502QSCW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020161_2_0_1"/>
    <dbReference type="OMA" id="SNQRWTR"/>
    <dbReference type="OrthoDB" id="3055998at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF76">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012406915" description="Beta-xylanase" evidence="9">
        <location>
            <begin position="16"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="10">
        <location>
            <begin position="25"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS20178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="327" mass="36602" checksum="FDF3A8D3EEF2BACE" modified="2011-10-19" version="1">MKFNLLLLLAPLAAAAPTLETRQASESVDQLFKAKGKEYFGVCTDQGRLQQGRNAAIIEANFGQVTPENSMKWESLQPRQGQYNWGQADYLVNWATARNKTIRGHTFVWHSQLAGWVNNVRDRNQLTRVIQDHITTVMTRYKGKIYHWDVINEMFNEDGSIRSSVFSQVLGEEFVGIAFRAARAADPSAKLYINDYNLDNPTYAKITRGMVPNVQRWIQQGIPIDGIGTQGHLQSGQGNGLAQAIKVLAATPGIKEVAVTELDIQNNHVNDYVAVTRGCLEEPKCVGITVWGVRDQDSWRPAGNPLLFDSNYNPKQAYNAIVQLLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9T1</accession>
    <name>G0S9T1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-ribulosamine 3-kinase</fullName>
            <ecNumber evidence="1">2.7.1.172</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0047060</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N(6)-D-ribulosyl-L-lysyl-[protein] + ATP = N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48432"/>
            <dbReference type="Rhea" id="RHEA-COMP:12103"/>
            <dbReference type="Rhea" id="RHEA-COMP:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:90418"/>
            <dbReference type="ChEBI" id="CHEBI:90420"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.172"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:48433"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EC" id="2.7.1.172" evidence="1"/>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695077.1">
        <property type="nucleotide sequence ID" value="XM_006695014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9T1"/>
    <dbReference type="GeneID" id="18258744"/>
    <dbReference type="KEGG" id="cthr:CTHT_0047060"/>
    <dbReference type="eggNOG" id="KOG3021">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036517_1_2_1"/>
    <dbReference type="OMA" id="AWTKTAK"/>
    <dbReference type="OrthoDB" id="5772781at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102193">
        <property type="term" value="F:protein-ribulosamine 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016477">
        <property type="entry name" value="Fructo-/Ketosamine-3-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149">
        <property type="entry name" value="FRUCTOSAMINE 3 KINASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149:SF8">
        <property type="entry name" value="PROTEIN-RIBULOSAMINE 3-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03881">
        <property type="entry name" value="Fructosamin_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS20192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="276" mass="31996" checksum="9F8BCF32C60D6DC0" modified="2011-10-19" version="1">MLYKQDGSFPMHDDTVNRKITVQNQHGEEEYYFVKIAFRDIGRKMLQGEIESSKLIYETTPTFITKPYGFGEFPDSGLTAYFYLSQFVELDIEIPPDPDEFTQRLAYLHKMSRSPTGKFGFPVPTRDGDRPHIVDWQDSWAVFFRYLFLGVCRFDIARNGQWPEYERAIQQIADKVIPILLEPLQANGRKLKPCLIHGDLWEGNMGINLETGDSMIFDAASYFSHNEMEFGHWAYNNMCYLNEKYAPIEYMDKYDPALDPNITGLSIIPHLAEGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAB5</accession>
    <name>G0SAB5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0041680</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694572.1">
        <property type="nucleotide sequence ID" value="XM_006694509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAB5"/>
    <dbReference type="GeneID" id="18258206"/>
    <dbReference type="KEGG" id="cthr:CTHT_0041680"/>
    <dbReference type="HOGENOM" id="CLU_894287_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="311" mass="35513" checksum="CE9A8FC8598FBA61" modified="2011-10-19" version="1">MEHLNTCRQESVSPSSTSSSGPDSSGSSVFEKLHPSLYAPISRPFCPEHATLLMEIDIEYDRYKTASELCDLIIERIAFLCAKVSPVDPMTAQEYLEYFKESKSSLAEMRRHIQQGRYWVATVGIVPSMGGRLSDLRAVSSEVDSMIQLYRETKEMLEMLIRNVTKWEKSRNRWSPLIINPSRYEQHTLTLLIALLPAKFIDDNGRELEEFEEVMALSQKRRGSTATVQEVEERFRNLSLLGAAPFKEEDIRRGVEQAAKEPIVQRAMKMTDWKKPISEGVFADDVETEVQKEVQEQEMMDVPELVDVAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAK1</accession>
    <name>G0SAK1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">Histone acetyltransferase</fullName>
            <ecNumber evidence="3 14">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CTHT_0042570</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination. Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 14"/>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694658.1">
        <property type="nucleotide sequence ID" value="XM_006694595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAK1"/>
    <dbReference type="STRING" id="759272.G0SAK1"/>
    <dbReference type="GeneID" id="18258295"/>
    <dbReference type="KEGG" id="cthr:CTHT_0042570"/>
    <dbReference type="eggNOG" id="KOG2747">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005327_0_3_1"/>
    <dbReference type="OMA" id="DNAHRQC"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990467">
        <property type="term" value="C:NuA3a histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF161">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16866">
        <property type="entry name" value="PHD_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="16">
        <location>
            <begin position="198"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="MYST-type HAT" evidence="17">
        <location>
            <begin position="534"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="41"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="238"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="324"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="409"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="841"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="885"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1050"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="69"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="885"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="918"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="966"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1050"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1075"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="12">
        <location>
            <position position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGS19773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1124" mass="125106" checksum="4B2B67A0CAECA466" modified="2011-10-19" version="1">MADAQLMEEQLQRSVMRDAEMIQHISDGVVAVGDDGSYASHSHIVVHDGEFDAEGDIDMDTAEEQRQDYDEDEQSESEEEDSGNSNSEEEEDEEEDDDDDDDSFEEDAEGEEDDEVIQRRRLPQRRLASRVTSRHSAEDDDDEGVGAVKFRPGETEDEDSRSESASSASGSDDDSDGDEEWHEADHDDGDDDESADTTGLCIFCKQDEDHDPSEEFEVYLACTRCGDNAHQQCARENEAITSEQGPGNWRCPKCAGMDSDSDAAVEENEATTAMDSAAEPNPSSSRRTSVPKLACDLLPSQKGIIKPDSHSVFNQLVLDEDPMDGSRVLRKRKTSSTEADDGVMTLRKRRKATTDGQSNDEGATNQDDSSRPVSRSLRIKIANAPASIIKNTRGSLIVKFRVNSSELRQILSRKPRGSRKRSTGRSSRRRTSRNDSRRIAALPVAPITTPFTPTAYSQPFYSFFDKETDEMKGKPYGGILSEAEADTSKTMPTNEDRRRFDEAKQKAEEEWRERVLKMQAEMELPPKKSKKASGPASQIECIEFGGWEIDTWYAAPYPEEYSRNRVLYICEFCLKYMNSDYVAWRHKLKCPAKHPPGDEIYRHGSVSVFEVDGRKNPVYCQNLCLLAKLFLGSKTLYYDVEPFLFYVLCEYDELGYHFVGYFSKEKRASSQNNVSCILTLPIHQRKGYGNLLIDFSYLLTRVEKKTGSPEKPLSDMGLVSYRNYWRLVMCRYLLEHFSEEKSGKMGLSIKQISEDTGMTPDDVISALEGLRALVKDPQTQLYALRVDLQYCREYVEKWEAKGYVKLNPNALTWTPYVMGRSNSLNFELAPTLSAIAARDDDEEIKPDPPVEDPLINGSNSPTRREDPPPDIKINFNTTILQSAEKDAMHSAVKGDPKPSESDGADDAPDDQKFNSGPDSKDSEGDDWMLKYKDIPPTRFEPVPPVPGRRSADRSRSVVIPRPPTVRSAGSSTSRPRSRRLTAGSRRSTTSRPRTSGSNSSKRRPGGTGRGPGRWPKGTKKSDYGNADSGPGFPPAWIAERNRLAALAAAKKEAAEKQKEEEATAVGESGEVRDTVQVQSTAVSDQLNGSVAAGSKTPRGKGKGKAKEVPTDVVMGEADAEGEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAL3</accession>
    <name>G0SAL3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative copper-activated transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0042690</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694670.1">
        <property type="nucleotide sequence ID" value="XM_006694607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAL3"/>
    <dbReference type="STRING" id="759272.G0SAL3"/>
    <dbReference type="GeneID" id="18258307"/>
    <dbReference type="KEGG" id="cthr:CTHT_0042690"/>
    <dbReference type="eggNOG" id="ENOG502SQDA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036162_0_0_1"/>
    <dbReference type="OMA" id="DSCECAG"/>
    <dbReference type="OrthoDB" id="5600085at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="424" mass="44262" checksum="DEC24A02B756F470" modified="2011-10-19" version="1">MPIINGQKMACEEGSPAGTPTSPTRPSYRVSKASSSTKVSRKQSFDLANLERMDPNSINLMAPSTNGNGVPSGISAPDSAIPVSQSELPGLNQGMGLVSASSGNIYSHPSTAAYGPSVSYGMGFHYSQTNPLQHNITQDGGFITSVNGGFDPAMSHPHPPSQFVNGNHTPSGLDGQTHPPVVNHSLPKVQSGSTTPAPGGCCGVFTYPSDYGSWQHPLDPFSWQQIVAQTANSMPSQPLSSSIPQPQQESHVTTSNSFQTTTGTTVQVDGMMHQCSCGDGCQCVGCLAHPFNSQMYQYVNNAYAGSNGSSPRTGGPDYPTTTSASQSQIAVTTTGQDYQQPQQPPQHQQQHSPLLPEAALTPASSEGAGASPREEQSLSTMDYFFVNIPISGLMCGGSVESCPCGDSCECAGCLVHGNVNTGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAM6</accession>
    <name>G0SAM6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cell division control protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0042820</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694683.1">
        <property type="nucleotide sequence ID" value="XM_006694620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAM6"/>
    <dbReference type="STRING" id="759272.G0SAM6"/>
    <dbReference type="GeneID" id="18258320"/>
    <dbReference type="KEGG" id="cthr:CTHT_0042820"/>
    <dbReference type="eggNOG" id="KOG2398">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003525_0_0_1"/>
    <dbReference type="OMA" id="ETTVRWN"/>
    <dbReference type="OrthoDB" id="27823at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120104">
        <property type="term" value="C:mitotic actomyosin contractile ring, proximal layer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106006">
        <property type="term" value="F:cytoskeletal protein-membrane anchor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07651">
        <property type="entry name" value="F-BAR_PombeCdc15_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000045">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000164">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF7">
        <property type="entry name" value="NOSTRIN, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="F-BAR" evidence="10">
        <location>
            <begin position="14"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="1075"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="276"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="688"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="332"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="383"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="478"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="518"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="611"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="639"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="730"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="761"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="795"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="886"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="918"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="936"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
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            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS19798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1135" mass="121868" checksum="2F3149C989DCA05A" modified="2011-10-19" version="1">MPAATTDQPPTVALSFANNFWGKDDAGVAPLFERMHNAKITCDELRAFYAARASIEDEYARKLLSLCKKSLGSHEMGTLKQSLDVVRAEVESMARQHQNVAAQMKSELEEPLAAFAGAMKERRKIVQNTIEKLLKTKIQQTQLVNKTRDRYEQECLKIKGYLAQGHMVMGQEERKNKAKLEKTQISLAQSNAEYEAAVKALEETTARWNREWKAAADKFQDLEEERLDFTKSSLWTFANISSTVCVSDDASCEKIRLSLEKMEVEKDIELFIREKGTGQEIPEPPKYINFCRGDLDSQSEASEDDPGYTVAQFPRSINPAFRSSSPQPSMFESHHDPDSQLARDLRHGPPANDNIDMPPVSQPAPAPQQKQLKAPPQQPQLPAPETNGNNNNNKNNNNTTTTAVTAAAARRREPPRGYQPPKAASLEYDPSEYPPVPHDPYPMDGMTMLCRPTASELSTAPSTSSASARPVSRESRSETTFSSQEPQQQQQQQQQQQQQQQQQVQDQPFPPQAQAQPQPQPQPQSQPQPPQTQTQAQPERAVEAATSSSPDKKVLKKKSGFFQNHSPFRRKSMKEVAAANRNTWAPSSSTSSVSGGARPTLPQLAAAPKDNANVNSTSSSNNSNQLIAPDRSVSPEPLPTNTSLALNIGNNVFPVETPDRQMQQAPAPDTPEDDPIAMALAELKGVTAGARQNGGAGGPPGMRMSADHYHGIATPAPPGANPNSRPNTAGNGGATGNGTSGTSTSLVMRNTPPPSYDNSGQVGQQPQNVQPIVPVSRLGVPPPAVTSKAMKEASQRFQQQTRNLFSDRPSSGSGNNFSASTGSNSRGDGSPMSRPGTRGGLASSTSSYGSRDGNDGAVVPRSASPGPHYGSSYHRSASPRPGSRAGPGYTQQGQQGQSNGRISPSPYSAGGGGGVRGSMTQLAMTHQPSKRGSMDPYYSPSPTSQSYGRGNSPSVDMGNPRSVSPAFSYRSTGDGRPGSSMDSYHQMQLAPVSAVGGPSMDDPGYHSGSSMRGRHQRSHTASGREISFGNGGGSVRGQMSLYEGAGAVQVAGAGGMSRSRSRSVVGAGFARDGRVILHYARALYAYQAAIPEELGFAKGDILAILRHQDDGWWEAFVQGGNGQTGLVPSNYLQPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAW7</accession>
    <name>G0SAW7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thiosulfate sulfurtransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0048050</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695169.1">
        <property type="nucleotide sequence ID" value="XM_006695106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAW7"/>
    <dbReference type="STRING" id="759272.G0SAW7"/>
    <dbReference type="GeneID" id="18258843"/>
    <dbReference type="KEGG" id="cthr:CTHT_0048050"/>
    <dbReference type="eggNOG" id="KOG1529">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031618_3_1_1"/>
    <dbReference type="OMA" id="NNNWFAS"/>
    <dbReference type="OrthoDB" id="270167at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01448">
        <property type="entry name" value="TST_Repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01449">
        <property type="entry name" value="TST_Repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000001">
        <property type="entry name" value="Sulfurtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000033">
        <property type="entry name" value="Thiosulfate sulfurtransferase TUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364:SF27">
        <property type="entry name" value="SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="THIOSULFATE SULFERTANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="99"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="226"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS19347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="350" mass="39146" checksum="E64FA0927C290930" modified="2011-10-19" version="1">MITISALRLLRASLSQRGCFNFSRTAPSGPSYHFVIAKHGARRSFSSYLVTPQELSDALKKSPQSPNSSEPRVIPLCASWFLPNDPKGRTGIQVFTEKRIPKARFFDLDKVIDKHSPYPHMLPTPKHFAEAMSELGIRYEDIVVVYDSAELGIFSAPRVAWTMRVFGHPKVHILNNFRLWVEQGLPTESGNVWTVECGTYPIPEMDEDRVASFEEVKEIAEKLKEGAKDVQILDARSYGRWSGQAPEPRPGLSSGHMPGSINVPFDAVLDPETKAFLPPERIREVFKSKGVDPEKPIISSCGTGVTACVLETALRVSEYGSPENRKVYDGSWTEWAQRVSPSEDLIQTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAY2</accession>
    <name>G0SAY2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CTHT_0048210</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the histone H2B family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695184.1">
        <property type="nucleotide sequence ID" value="XM_006695121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAY2"/>
    <dbReference type="STRING" id="759272.G0SAY2"/>
    <dbReference type="GeneID" id="18258859"/>
    <dbReference type="KEGG" id="cthr:CTHT_0048210"/>
    <dbReference type="eggNOG" id="KOG1744">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075666_1_3_1"/>
    <dbReference type="OMA" id="FCPFAIR"/>
    <dbReference type="OrthoDB" id="10254238at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000014">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12 13" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="15">
        <location>
            <begin position="33"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGS19362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="140" mass="15089" checksum="A9D268D18B86870B" modified="2011-10-19" version="1">MAPKADAQKKPASKAPASTASKAPSEKKDAGKKTAASGEKKKRTKARKETYSSYIYKVLKQVHPDTGISNRAMSILNSFVNDIFERVATEASKLAAYNKKSTISSREIQTAVRLILPGELAKHAVSEGTKAVTKYSSSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0SB01</accession>
    <name>G0SB01_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0048400</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification.</text>
    </comment>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695203.1">
        <property type="nucleotide sequence ID" value="XM_006695140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SB01"/>
    <dbReference type="STRING" id="759272.G0SB01"/>
    <dbReference type="GeneID" id="18258878"/>
    <dbReference type="KEGG" id="cthr:CTHT_0048400"/>
    <dbReference type="eggNOG" id="KOG0280">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036100_1_0_1"/>
    <dbReference type="OMA" id="LDMKWLP"/>
    <dbReference type="OrthoDB" id="1930760at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061685">
        <property type="term" value="F:diphthine methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052415">
        <property type="entry name" value="Diphthine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042:SF1">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS19381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="427" mass="47809" checksum="2F1B880C896466A9" modified="2011-10-19" version="1">MADEGQLVTSIKRAELDLPPSCIEFCPAFPSYFVVGTYSLQPDGSGNDNGQGGEEEIGERQERARQPQSRKGSIILFRLIEGELTKLYTEQYPSAVLDLRFSPHQFCRDIFAVVSSTATVSLYRVVYGSAARLRHLRMLDIVSMSKGAITPELGSEIIFTSFSWHSTRTDVLAISSTPGQVYIVRLPPLNKLPAAMDEPPAPGEWHLYEEPVLTHTLESWTVVISPSMGLPVLGQADEGDYFCRVYSGGDDSMLRYRTCKWDKDGNFSADLPAIESRGHDAGVTAILPLFFADDGRELVVTGSYDEHIRLFAVPVFGKAVNLAKSCLGGGVWRLNLINLKKEPKKGEYRWRASILASCMHAGARIVELRQTEGGEYQFRVLVRFEEHKSMNYGSDITPDKWREKLPVVSTSFYDKLLCVWEIHRDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0SB23</accession>
    <name>G0SB23_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0048620</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAUS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695225.1">
        <property type="nucleotide sequence ID" value="XM_006695162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SB23"/>
    <dbReference type="GeneID" id="18258900"/>
    <dbReference type="KEGG" id="cthr:CTHT_0048620"/>
    <dbReference type="eggNOG" id="ENOG502S1U0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068908_0_0_1"/>
    <dbReference type="OMA" id="QAKDWAY"/>
    <dbReference type="OrthoDB" id="5372507at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070652">
        <property type="term" value="C:HAUS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026243">
        <property type="entry name" value="HAUS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31570">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31570:SF1">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25762">
        <property type="entry name" value="HAUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="188"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="58"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS19403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="323" mass="35083" checksum="EF2F2567381C19E6" modified="2011-10-19" version="1">MSLPPTAAIFSPSVARAAASAAKDWSYIDAWLTRKFPNRPSLPAFERNADTLRILLALATANDAADEQRALVARLEKEALKEVEEWERQQQQKETEAEGEADILGPARKAILQGIESALPREGQTALDAMAALAVQRGIAHPTPALLAEDLIALSAQAAALDEAISRVQTLAEHIAREAERTAALAAELKPPEPGAQHNEEEEDGEKTSKESSDTPTSKPLSFTGYHPPTSLALHNLSLQRHIKSLSTRLPELRDKSASSLSPSLAHNNVPVTLQQVREEEAAYRALLEQKQMLDAKLRELAGLPPDEAEAKKGLGQQRRGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBE7</accession>
    <name>G0SBE7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative microtubule motor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0050010</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695349.1">
        <property type="nucleotide sequence ID" value="XM_006695286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBE7"/>
    <dbReference type="STRING" id="759272.G0SBE7"/>
    <dbReference type="GeneID" id="18259039"/>
    <dbReference type="KEGG" id="cthr:CTHT_0050010"/>
    <dbReference type="eggNOG" id="KOG0242">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001485_27_3_1"/>
    <dbReference type="OMA" id="EVENDPM"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00106">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF9">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="4">
        <location>
            <begin position="2"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="591"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="489"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="598"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="623"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="90"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS19527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="728" mass="81281" checksum="11F537276E86F986" modified="2011-10-19" version="1">MSVRVVARIRPLLDKESSSDIIVRADRVAEGKSLTVVKIPNPKNEAEEFSFSFNSVYTDETTQEEFFNAEVTPHIKPLFAGVNLTIFAYGATGTGKTHTMRGGLRLADRGIIPRLLSAVFRRAKKVTKDSAGKTTVRVALSYYEIYNDRVYDLLTPPDKRTPAGLPLREKDGKTVVVGLQERECADLKDFEKLYIEANQHRVTAATKLNAHSSRSHAIIRVQITQTTSDMVLESVASAIDLAGAEDNRRTENDKTRMVESAAINKSLFVLSQCIDAIVKGEQRVPYRESKMTRILGLGQNQGVTVMILNLAPVRKYHLDTLSSLNVGCRVKRIEVKEVKNESVFKAPKELTTGRQPLKPIMNAHNVATRAMVGKERGETEKEKGKPERLFNVYVDKKPAPTATTTARQNSTAVLGARLPLAPKRPSDEPLTLSSHPIKFARRALAPKHTASSRQHQQHITVTVTPSELEALVEKKVAEVLASRQLHSPLETQAQLSEDVRRRLEVLERKVEEEAAKKDGAERAKGLRCLLNAKQAKECGDEVTALGWYEKALAVFPGEGRLVGKIERLRAKLGLPSLFEEEERAAEREKKLRRKKLEEEDEYQDWMDVDAPENSIEPRKSRTQKAPSKNTETSKFVVPDKENQPWPLPSDYTTDCPPSPRTQQLLDIINSRDVARIKGLHGFGAKKAQDLVTAMNTYKGEESVKSLEEVRKLPGVGRVVERAYEGLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBL1</accession>
    <name>G0SBL1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding nuclear protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0053970</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the small GTPase superfamily. Ran family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695732.1">
        <property type="nucleotide sequence ID" value="XM_006695669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBL1"/>
    <dbReference type="STRING" id="759272.G0SBL1"/>
    <dbReference type="GeneID" id="18259435"/>
    <dbReference type="KEGG" id="cthr:CTHT_0053970"/>
    <dbReference type="eggNOG" id="KOG0096">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_13_0_1"/>
    <dbReference type="OMA" id="FNAWDTA"/>
    <dbReference type="OrthoDB" id="48625at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00877">
        <property type="entry name" value="Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000131">
        <property type="entry name" value="GTP-binding nuclear protein Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002041">
        <property type="entry name" value="Ran_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071:SF0">
        <property type="entry name" value="GTP-BINDING NUCLEAR PROTEIN RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071">
        <property type="entry name" value="RAN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00627">
        <property type="entry name" value="GTPRANTC4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51418">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS18787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="216" mass="24390" checksum="570458A6D19C3A2A" modified="2011-10-19" version="1">MAEQQQQIPTFKLVLVGDGGTGKTTFVKRHLTGEFEKKYMATLGVEVHPLGFTTNFGPIQFDVWDTAGQEKFGGLRDGYYINGQCGIIMFDVTSRITYKNVPNWHRDLTRVCENIPIVLCGNKVDVKERKVKAKTITFHRKKNLQYYDISAKSNYNFEKPFLWLARKLVGNPALEFVAAPALAPAEVQVDQNLLAQYQAEMEEAAKAPLPDDDDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G0SC20</accession>
    <name>G0SC20_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein disulfide-isomerase</fullName>
            <ecNumber evidence="3">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0055600</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="3"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695891.1">
        <property type="nucleotide sequence ID" value="XM_006695828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SC20"/>
    <dbReference type="STRING" id="759272.G0SC20"/>
    <dbReference type="GeneID" id="18259598"/>
    <dbReference type="KEGG" id="cthr:CTHT_0055600"/>
    <dbReference type="eggNOG" id="KOG0191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030577_0_0_1"/>
    <dbReference type="OMA" id="NHVKRAT"/>
    <dbReference type="OrthoDB" id="10264505at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03002">
        <property type="entry name" value="PDI_a_MPD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02981">
        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057305">
        <property type="entry name" value="Thioredox_PDIA6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815:SF3">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24541">
        <property type="entry name" value="Thioredox_PDIA6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409467" description="protein disulfide-isomerase" evidence="8">
        <location>
            <begin position="23"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="9">
        <location>
            <begin position="6"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="242"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="438"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="257"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="272"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="443"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="487"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS18946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="497" mass="53375" checksum="75DE91B4E7F21EB6" modified="2011-10-19" version="1">MHHTTLSTLAMALLATLPGAQAGLYTKKSPVLQVDAKDYDRVIAKSNYTSIVEFYAPWCGHCQNLKPAYEKVAKNLAGLAKVAAVNCDDDANKPFCGSMGVQGFPTLKIVRPKKGGGKPIITDYQGPRTATAIVDAVVQQINNYVVRIEDKSLDKFLSDKNETAKAILFTEKGTTSALLKSLAIDFSDVITIGQVRNKETRAVETFGISKFPTFILLPGGDAPGIVYDGEMKKEALVKFLSQAGQPNPDCPPPKAKSNGDKKDKKSAKTSEQKSSTKSKTSTASAESKVESTTQEAPVIVETALPIPAINTHEKLVKECLNEQAHTCVLAFVSSSEDEKARKALSSLSQLAHKHAQSKRKLFPFFEVPTKDNEGAASVLKALELTGDVELVAVNARRGWWRHYEAGDFNHKSIESWIDAIRMSEGTKKKLPEGIIAAAAEKPSSSSLAATSESTPQPAEDSSSTETAGTAGSSTEAMSTESASSTAEPEKVEEHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G0SC83</accession>
    <name>G0SC83_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0056290</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CTAG/PCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695954.1">
        <property type="nucleotide sequence ID" value="XM_006695891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SC83"/>
    <dbReference type="GeneID" id="18259667"/>
    <dbReference type="KEGG" id="cthr:CTHT_0056290"/>
    <dbReference type="eggNOG" id="ENOG502SBSA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113770_3_1_1"/>
    <dbReference type="OMA" id="VQYRATT"/>
    <dbReference type="OrthoDB" id="10025739at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000011">
        <property type="entry name" value="Transcription factor Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015419">
        <property type="entry name" value="CTAG/Pcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283">
        <property type="entry name" value="EKC/KEOPS COMPLEX SUBUNIT PCC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283:SF5">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT LAGE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09341">
        <property type="entry name" value="Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="108" mass="11794" checksum="9CDAB4D2142F8B00" modified="2011-10-19" version="1">MATPEATGFPCALTLNVPFPDSRLASVALQALRVDKELSPLVTRELSTVAAEGATDQTVLRVVYKAATNRMLRVAVNSFFDSLALVLEVMEELDVDVIEARQKQEKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G0SC99</accession>
    <name>G0SC99_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0056460</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695970.1">
        <property type="nucleotide sequence ID" value="XM_006695907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SC99"/>
    <dbReference type="GeneID" id="18259684"/>
    <dbReference type="KEGG" id="cthr:CTHT_0056460"/>
    <dbReference type="eggNOG" id="ENOG502S32Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084247_0_1_1"/>
    <dbReference type="OMA" id="WMMAAKA"/>
    <dbReference type="OrthoDB" id="206452at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15457">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012816">
        <property type="entry name" value="NADAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037238">
        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02464">
        <property type="entry name" value="ribofla_fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08719">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADAR" evidence="2">
        <location>
            <begin position="14"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS19025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="223" mass="25639" checksum="75E77C85E2C7F999" modified="2011-10-19" version="1">MASSTTSPALPPVYFWRQREPEGGCFSQWYHCAFFDPEDPSVVYPTAEHYMMYQKALLFNDTAIAPRILSARHPRDVKALGRQVKNFNEAIWRRERERIVLKGNILKFTNPVARDEGSGWFVKVTETVSGEEGEKNEEGTRTVTTSYTLREMLLRTGDREIVEASPMDRIWGIGFAAGKAEEVGRERWGLNLLGKALMEVRRLLREEERKKRRMRRGRGGGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0SD04</accession>
    <name>G0SD04_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar protein sorting-associated protein 28</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ESCRT-I complex subunit VPS28</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0059010</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the VPS28 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696220.1">
        <property type="nucleotide sequence ID" value="XM_006696157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SD04"/>
    <dbReference type="STRING" id="759272.G0SD04"/>
    <dbReference type="GeneID" id="18259939"/>
    <dbReference type="KEGG" id="cthr:CTHT_0059010"/>
    <dbReference type="eggNOG" id="KOG3284">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076417_0_1_1"/>
    <dbReference type="OMA" id="CDEFPTV"/>
    <dbReference type="OrthoDB" id="2671at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.200:FF:000003">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1130:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 28 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007143">
        <property type="entry name" value="Vps28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017899">
        <property type="entry name" value="VPS28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037206">
        <property type="entry name" value="VPS28_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017898">
        <property type="entry name" value="VPS28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038358">
        <property type="entry name" value="VPS28_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 28, ISOFORM 2 VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03997">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017535">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140427">
        <property type="entry name" value="VPS28 C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51310">
        <property type="entry name" value="VPS28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51313">
        <property type="entry name" value="VPS28_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0967">Endosome</keyword>
    <keyword evidence="4 5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS28 N-terminal" evidence="8">
        <location>
            <begin position="19"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="VPS28 C-terminal" evidence="7">
        <location>
            <begin position="143"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS19275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="237" mass="26326" checksum="A20DCF4E9738E0F9" modified="2011-10-19" version="1">MISRQPYAPTPHSYVPNTTLSATINLDEEVKLAETRAERDLQESLAELFSIIVTIDELEKAFLKDAIPEAEYTEICERSLKQYKSLLADETVARAFGGLEEFKAQWDLEVPRATERIRVGMPATAVTASSGPATASTAAAANTNGALIVEATQDFITFLDALKLGLLSKDQLHPLLTYVIQSVNKVTDRDFENRGKIVQWLITLNQMKATEELSEEQARELEMDINAAYQGFKNLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDI4</accession>
    <name>G0SDI4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0051900</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695530.1">
        <property type="nucleotide sequence ID" value="XM_006695467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDI4"/>
    <dbReference type="STRING" id="759272.G0SDI4"/>
    <dbReference type="GeneID" id="18259228"/>
    <dbReference type="KEGG" id="cthr:CTHT_0051900"/>
    <dbReference type="eggNOG" id="KOG1414">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034316_1_0_1"/>
    <dbReference type="OMA" id="HGAFMSQ"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000053">
        <property type="entry name" value="BZIP transcription factor AtfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002112">
        <property type="entry name" value="Leuzip_Jun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021755">
        <property type="entry name" value="TF_Aft1_HRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021756">
        <property type="entry name" value="TF_Aft1_HRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020956">
        <property type="entry name" value="TF_Aft1_OSM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11786">
        <property type="entry name" value="Aft1_HRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11787">
        <property type="entry name" value="Aft1_HRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11785">
        <property type="entry name" value="Aft1_OSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00043">
        <property type="entry name" value="LEUZIPPRJUN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="491"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="192"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="578"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="516"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="362"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="487"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS18585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="619" mass="64164" checksum="21335165BCA7B28B" modified="2011-10-19" version="1">MGSPSGAAGRGGDSSSPNQPGSISLSQDASSDVKRSSSVKVEEPAAHYASPASSSQPSSSSSSASSSVPVSMSKNTTSAPENSSSTTLPPPSTAPTVPITNSNPKLPTQLPPLTRPPQSSTAPRKTSSPDYFSHKASLSLEPNPFEQSFGNAPVETPGGTKLPSVAALTSPSSLLPGGSPFWGQGSLRTGPLSPAMLSGPANNDYFGDPHPIPRGFPTPNESSLRTGLTPGGSGSMFPAPSPTSQSLFSLSGPAATPGTLDFHRTALNAAAAKREQSQTQQPPTLPPPQPSNTAPTSQPQEMSNGLSAPKPAEPRPAPPTASTFDPHDNDAANGLFMLAQGRSATQLPPPQPYNVPSIQLHTTSAAPAPAQQPTTSTSPQVGGAPSVSGSSGRGASEASARSEESEGARPSTRAKGKRTSSSTATNARRKAEEPAAKAPAAKKTKTNSENGAEEEAQNNDANANNEEGAKENKPSTSSSNASSSKAKMTDEEKRRNFLERNRVAALKCRQRKKQWLQSLQQKVEMFSSENDQLTQQITQLREEVVNLKTLLLAHKDCPVTQQQGLHGAFLQQALEPFNHQPPPAAAPAGALNPYATIPPSIPPPSQPVLAGQSVSRRYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDK3</accession>
    <name>G0SDK3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Putative transcription factor kapC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0052090</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Putative transcription factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bZIP family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695549.1">
        <property type="nucleotide sequence ID" value="XM_006695486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDK3"/>
    <dbReference type="STRING" id="759272.G0SDK3"/>
    <dbReference type="GeneID" id="18259247"/>
    <dbReference type="KEGG" id="cthr:CTHT_0052090"/>
    <dbReference type="eggNOG" id="ENOG502S175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1524973_0_0_1"/>
    <dbReference type="OrthoDB" id="2593073at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="10">
        <location>
            <begin position="58"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS18604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="176" mass="19634" checksum="FAE6C43551972637" modified="2011-10-19" version="1">METYGDAVDNSFYYGNYPSRNPTPDTEENEPGQPTTDQKLKRKRENRYKNAPPAVLSRRRAQNRASQRAYRERKEQRIRDLEHMLNEARQRNDVLSQAYAALHAEYMALKNSQLAVGGDAGAVPGGYAQQQEQVELAYGTAISGAIDFGLVAITNPLGKPEMFGYDPNGLSGGYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDP4</accession>
    <name>G0SDP4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">inositol-3-phosphate synthase</fullName>
            <ecNumber evidence="6">5.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CTHT_0052500</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2024" name="Proc. Natl. Acad. Sci. U.S.A." volume="121" first="e2400912121" last="e2400912121">
            <title>Disorder-to-order active site capping regulates the rate-limiting step of the inositol pathway.</title>
            <authorList>
                <person name="Trager T.K."/>
                <person name="Kyrilis F.L."/>
                <person name="Hamdi F."/>
                <person name="Tuting C."/>
                <person name="Alfes M."/>
                <person name="Hofmann T."/>
                <person name="Schmidt C."/>
                <person name="Kastritis P.L."/>
            </authorList>
            <dbReference type="PubMed" id="39145930"/>
            <dbReference type="DOI" id="10.1073/pnas.2400912121"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.48 ANGSTROMS) OF 40-552 IN COMPLEX WITH NAD(+)</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10716"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="5.5.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the myo-inositol 1-phosphate synthase family.</text>
    </comment>
    <dbReference type="EC" id="5.5.1.4" evidence="6"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695590.1">
        <property type="nucleotide sequence ID" value="XM_006695527.1"/>
    </dbReference>
    <dbReference type="PDB" id="9F2K">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.48 A"/>
        <property type="chains" value="A=40-552"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDP4"/>
    <dbReference type="EMDB" id="EMD-50149"/>
    <dbReference type="SMR" id="G0SDP4"/>
    <dbReference type="STRING" id="759272.G0SDP4"/>
    <dbReference type="GeneID" id="18259288"/>
    <dbReference type="KEGG" id="cthr:CTHT_0052500"/>
    <dbReference type="eggNOG" id="KOG0693">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021486_2_0_1"/>
    <dbReference type="OMA" id="VYVPMKE"/>
    <dbReference type="OrthoDB" id="2887at2759"/>
    <dbReference type="UniPathway" id="UPA00823">
        <property type="reaction ID" value="UER00787"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004512">
        <property type="term" value="F:inositol-3-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000069">
        <property type="entry name" value="Inositol-3-phosphate synthase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000204">
        <property type="entry name" value="Inositol-3-phosphate synthase 1-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002587">
        <property type="entry name" value="Myo-inos-1-P_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11510">
        <property type="entry name" value="MYO-INOSITOL-1 PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07994">
        <property type="entry name" value="NAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015578">
        <property type="entry name" value="Myoinos-ppht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="18" id="KW-0002">3D-structure</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0398">Inositol biosynthesis</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myo-inositol-1-phosphate synthase GAPDH-like" evidence="15">
        <location>
            <begin position="346"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGS18645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PDB" id="9F2K"/>
        </source>
    </evidence>
    <sequence length="552" mass="60105" checksum="A441DF297CE6C13B" modified="2011-10-19" version="1">MAPHAEVDAGLANGGGQANGNGVAAAVAAPTVAPTTVSPIFKVNSPNVVYTDDEIRSKYVYRTTEVTTAEDGSLIATPRETVYDFKVDRKLPKLGVMLVGWGGNNGSTITAGIIANRRGLVWETRNGKQEANYYGSVIMGSTIKLGTDAKTHKDINIPFHSVLPMVHPNDIVIGGWDISGLNLADAMDRAQVLEPSLKALVRKEMASMKPLPSIYYPDFIAANQEDRADNILPGNKACWEHVEEIRKNIRDFKAANGLDKVIVLWTANTERYASIIEGVNDTADNLLNAIKNGHEEVSPSTVFAVSSILEGVPFINGSPQNTFVPGCIELAERHGAFIGGDDFKSGQTKMKSALVDFLINAGIKLTSIASYNHLGNNDGKNLSSQRQFRSKEISKSNVVDDMVEANTVLYKPGEHPDHIVVIKYVPAVGDSKRAMDEYHGEIFLGGHQTISIANVCEDSLLASPLIIDLVIVAELMTRIQWRLHKEDATEADWKYFHSVLSILSYMLKAPMTPPGTPVVNALAKQRAAMANIFRACLGLDPENDMTLEHKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDW8</accession>
    <name>G0SDW8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0053270</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695664.1">
        <property type="nucleotide sequence ID" value="XM_006695601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDW8"/>
    <dbReference type="GeneID" id="18259365"/>
    <dbReference type="KEGG" id="cthr:CTHT_0053270"/>
    <dbReference type="eggNOG" id="ENOG502QRB5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034574_2_0_1"/>
    <dbReference type="OMA" id="FWIFTIC"/>
    <dbReference type="OrthoDB" id="4480814at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G07470)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409466" description="Integral membrane protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS18719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="40214" checksum="2EA229383981672D" modified="2011-10-19" version="1">MANPGRFLCIALPFLLTLASLISMLVAGLAGVADKKLYMFRINTTDLEISPLNVQNILNQAGVNIPNNVNLDNINIPNNVNLDNINIPNVKIDIDKRQSQSKNITAADLGLHNLYDISIFTYCYTDQSGDRHCPKPAFNWARSALNTTPGDFNSLITTTGLNVTLPEEITSAIRVFTTVSRWTQYIYIAAIGALVVELFFGLFANCSRAMSCVTFLVAGVAAVLVGTAAAMATATAATVVGAVEASAKYYGVDSKINTRFLSAVWFAFTFAAAAALFWCFTICCCKPDRYKSAGGGVRHRDESASEKFIPLASGAGASAKGYQRLSEASLGENGNTGYYGAGGYSAGYPRQYPEPVAYGAQRESAYEPYSHVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0SE54</accession>
    <name>G0SE54_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative GTPase activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0062480</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696562.1">
        <property type="nucleotide sequence ID" value="XM_006696499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SE54"/>
    <dbReference type="STRING" id="759272.G0SE54"/>
    <dbReference type="GeneID" id="18260286"/>
    <dbReference type="KEGG" id="cthr:CTHT_0062480"/>
    <dbReference type="eggNOG" id="KOG1092">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018687_4_0_1"/>
    <dbReference type="OMA" id="MYPTARK"/>
    <dbReference type="OrthoDB" id="26371at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000007">
        <property type="entry name" value="TBC1 domain family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000037">
        <property type="entry name" value="TBC1 domain family member 22A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000001">
        <property type="entry name" value="TBC1 domain family member 22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF26">
        <property type="entry name" value="LD44506P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="245"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="556"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS18231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="574" mass="65072" checksum="2F1516F36DC1FA79" modified="2011-10-19" version="1">MVGCPSRQAAGFIRTTVRPQHLLCRKTTDWHVEQEMVQVDKSENITGSGTRPRTPPSTDRHSVISPARKSSSKASSPPFKSYINFLSNTNDDWNIDDAEDMYIYESDDGDDFGLPSLSNMKRRTRKMTEQSKTAAENGLGNDSPSGHESRRRMSDSADIAVERPACMYPMPKKSEGKILRPQYKEILRDPANALHLINYPTIPPNATQKEIDEINSRITRINKFKRLLQASTISLPELRALAWSGVPQEVRAMTWQLLLSYLPTSAERRVATLERKRKEYLDGVRQAFEKGGPQAASSGRTGGRGLDEAIWHQISIDVPRTNPHIELYGYEATQRSLERILYVWAVRHPASGYVQGINDLVTPFWQVFLGMYITDPDIESGMDPGQLPKAVLDAVEADSFWCLTKLLDGIQDHYIVAQPGIQRQVAALRDLTARIDAGLARHLEKENVEFIQFSFRWMNCLLMREISVKNTIRMWDTYMAEEQGFSEFHLYVCAAFLVKWSDRLVKMDFQEIMMFLQSLPTRDWTEKDIELLLSEAYIWQSLFKGSSAHLRGQGQGSSSQAGALAPGATKNFQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEF2</accession>
    <name>G0SEF2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative mitochondrial carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0063530</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696660.1">
        <property type="nucleotide sequence ID" value="XM_006696597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEF2"/>
    <dbReference type="STRING" id="759272.G0SEF2"/>
    <dbReference type="GeneID" id="18260391"/>
    <dbReference type="KEGG" id="cthr:CTHT_0063530"/>
    <dbReference type="eggNOG" id="KOG0764">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_6_1_1"/>
    <dbReference type="OMA" id="AFYNGMG"/>
    <dbReference type="OrthoDB" id="10266426at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990519">
        <property type="term" value="P:pyrimidine nucleotide import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF1">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06780)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="97"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="198"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="332"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS18329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="481" mass="51968" checksum="D5DFED0112EB2458" modified="2011-10-19" version="1">MSHNQHPLSAHSQAAPTSPAEYGVALPQRPPPLSRSAPAPTVEPPLVPPTTVAVAATASTIESAVDSLSPSSTAAMPDDVPPHLQLTYLERWAVDASDSRFNALAGAIGGFASGIVTCPLDVIKTKLQAQGGFSTRGAHQTRVYKGLFGTASVIWREEGLRGMYRGLGPIIMGYLPTWAVWFTVYNKTKKVLGEYHSNSFVVNFWSSIIAGASSTVATNPIWVIKTRLMSQSNPHSRSASSIPLLPPKGPGAGNTPTSRPVHYHPWHYKSTWDAARKMYTTEGILSFYSGLTPALLGLTHVAVQFPAYEFLKVRFTGRAMGASAPEGEDDKGHWFGILSASILSKILASSATYPHEVIRTRLQTQRRPIPGQEYMEGLGGLTTQPAMGNGVSLPEKGSSEVKVQHQGPKYKGIISTFRTMLREEGWRAFYAGMGTNMMRAVPAATVTMLTYEYVMRRLNHVRASGNGKLAMIEAGRGEFGS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-03-16" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEH7</accession>
    <name>DIM1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName>Dimethyladenosine transferase</fullName>
            <ecNumber>2.1.1.183</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>18S rRNA dimethylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">DIM1</name>
        <name type="ORF">CTHT_0063790</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(1779)/adenosine(1780) in 18S rRNA + 4 S-adenosyl-L-methionine = N(6)-dimethyladenosine(1779)/N(6)-dimethyladenosine(1780) in 18S rRNA + 4 S-adenosyl-L-homocysteine + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42780"/>
            <dbReference type="Rhea" id="RHEA-COMP:10234"/>
            <dbReference type="Rhea" id="RHEA-COMP:10236"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
            <dbReference type="EC" id="2.1.1.183"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <comment type="sequence caution" evidence="4">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EGS18354" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="2.1.1.183"/>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18354.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696685.1">
        <property type="nucleotide sequence ID" value="XM_006696622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEH7"/>
    <dbReference type="SMR" id="G0SEH7"/>
    <dbReference type="STRING" id="759272.G0SEH7"/>
    <dbReference type="GeneID" id="18260417"/>
    <dbReference type="KEGG" id="cthr:CTHT_0063790"/>
    <dbReference type="eggNOG" id="KOG0820">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041220_2_0_1"/>
    <dbReference type="OrthoDB" id="74991at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052909">
        <property type="term" value="F:18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000081">
        <property type="entry name" value="rRNA adenine N(6)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF7">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000435809" description="Dimethyladenosine transferase">
        <location>
            <begin position="1"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P41819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="384" mass="42546" checksum="4EA9D0F6A033780F" modified="2016-03-16" version="2">MPKTAKNKRNNAASGPYDKKSKGSGSTNIFKFDKDYGQHILKNPGISDAIVEKAFLKPTDVVVEVGPGTGNITVRALERAKKVIAIELDPRMGAEVTKRVQGTPLAKKLEVILGDVIKLPQIPPCDALISNTPYQISSPLIFKMLSMPQPPRVAVLMFQREFAKRLVAKPGDSLYSRLTVNVNFWATCTHIMKVGKANFKPPPKVESDVVRIEPYLGSARPNIAFEEFDGLLRIAFNRKNKTLRAAFSIKEVLALCEKNYKVYCTLHNIPLDESVLSDPSLTADMDVDMDANSDTDNDNDGDAMEEDDDDMPTFFKEVKEAEAAKEAAKTPSKNPKSKVALIVRAKINKVLTKTGLANKRARQCDQNDFLKLLLAFHEEGIHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEM5</accession>
    <name>G0SEM5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">U1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0064280</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696733.1">
        <property type="nucleotide sequence ID" value="XM_006696670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEM5"/>
    <dbReference type="STRING" id="759272.G0SEM5"/>
    <dbReference type="GeneID" id="18260466"/>
    <dbReference type="KEGG" id="cthr:CTHT_0064280"/>
    <dbReference type="eggNOG" id="ENOG502S9DW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041821_0_0_1"/>
    <dbReference type="OMA" id="WDSHVRG"/>
    <dbReference type="OrthoDB" id="77607at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033260">
        <property type="term" value="P:nuclear DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040050">
        <property type="entry name" value="ZNF830-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13278">
        <property type="entry name" value="ZINC FINGER PROTEIN 830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13278:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN 830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="U1-type" evidence="8">
        <location>
            <begin position="27"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="55"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="308"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="270"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS18402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="363" mass="40077" checksum="F0FC981B67B9696C" modified="2011-10-19" version="1">MADARALLRQQRAARRINHPLAAYLDNGKLVCTLCQEYIKIESLWDTHLHGASHRQRLQRQQQQAQASTRPIEPPRAGFIGDVEGERAAPSAKRKHDEPGPVAENGEDANDERRKRPKPDDATTLSEQRRLPGMGFGLEVQIPSRPATPGGTSSNTGSGTPMSLTPKTAPLGRSPLVTEESASQPEPALPNGPSHTQPNGPSSEEQVDEALWSAFEADLLQPSAVKTLTNPEMNPDAVILAPAMTAEEVAAKSEEEEQARRRALVDIQLEDEKEEATRKLEEEFEVMEELEARARRLREQREALRARVMSAGGRQGVAAVEKGDRGGKATTLVQEEEEDEDDDEDDDDDDDDDDDWDGFRFRA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-06-24" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0SER9</accession>
    <accession>G0ZGU7</accession>
    <name>NUP84_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleoporin NUP84</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Nuclear pore protein NUP84</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">NUP84</name>
        <name type="ORF">CTHT_0059480</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. NUP84 is involved in nuclear poly(A)+ RNA export, in NPC assembly and distribution, as well as in nuclear envelope organization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 6">Component of the nuclear pore complex (NPC). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Nucleoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="1">Symmetric distribution.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Nup84/Nup107 nucleoporin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS17935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JF276290">
        <property type="protein sequence ID" value="AEL00685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696266.1">
        <property type="nucleotide sequence ID" value="XM_006696203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SER9"/>
    <dbReference type="SMR" id="G0SER9"/>
    <dbReference type="DIP" id="DIP-60569N"/>
    <dbReference type="IntAct" id="G0SER9">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0SER9"/>
    <dbReference type="TCDB" id="1.I.1.1.2">
        <property type="family name" value="the nuclear pore complex (npc) family"/>
    </dbReference>
    <dbReference type="GeneID" id="18259986"/>
    <dbReference type="KEGG" id="cthr:CTHT_0059480"/>
    <dbReference type="eggNOG" id="KOG1964">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005882_1_0_1"/>
    <dbReference type="OMA" id="RYQGFCK"/>
    <dbReference type="OrthoDB" id="3098at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3450.20:FF:000003">
        <property type="entry name" value="Nuclear pore complex protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007252">
        <property type="entry name" value="Nup84/Nup107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003:SF2">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003">
        <property type="entry name" value="NUP107-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04121">
        <property type="entry name" value="Nup84_Nup100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0509">mRNA transport</keyword>
    <keyword id="KW-0906">Nuclear pore complex</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000433188" description="Nucleoporin NUP84">
        <location>
            <begin position="1"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="118"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AEL00685." evidence="5" ref="1">
        <location>
            <begin position="940"/>
            <end position="948"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P52891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="21784248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <evidence type="ECO:0000305" key="6">
        <source>
            <dbReference type="PubMed" id="21784248"/>
        </source>
    </evidence>
    <sequence length="948" mass="108081" checksum="5D58C105192A0BA1" modified="2011-10-19" version="1">MSPAFNIPDSIESSRGSSQSPHHGLNPEEMADIEATSQDNAVRVGEEIDYFAAQLDRYDADQTGSPPERRSRAFQLVDSYYTFTRKRLDRLRERQARQRSAQRGSWQRAGSIEMDLDDADEENDDILDEELQQLEDEVQIWDLLRRILPLRYHDATQNQKKEHDGSTKSRRQWWNEFMVSDSVARERKVVLEWLQNSASYGPPIDEVVSDLQHNAERGDILAHGWLHTRHKIKLQKSVNAYQGVLDPRDAAAAQSHLSSNSLITQLDPDAVTRQARKLEPQDESFERAIWLGCFEMLRRGCSMSEIREWLAVRTELWRAFSIAPLPLSNPDDEEQPDFDPVSLILWRRMCYAIATDGGTSDYDRAVYGLLAGDIPSVEKVCKTWDDVLFAHYNALLRTQFDLFLIKHGGDAAAKAAQQFPSFNAVAYHGDPATATKRLIDSLETGMKTSAEAFRPAKALQAAIVADDLDKFLFHQGLLLSIRANKKEKSKLIPEYPFPHESFSDKKYYDLGDHQGLRILAHVLIIILTLDRLSGVAKDKGPLQARHQAAENSIAAYISYLRLVRLEEMIPLYCSKLHGPRVYSTLSRNLIHIVDIDARLHQLTIMRNLGIDVSEFVKSQPLIYLDDVQDELVSCDAKDQFKILEDGPATLKYGRLVKPDFFGDDADYVDPEDDALIRSMEWLLLVPGLFVETCAYAVRIYKYFLKRTRLRAARAFSRRVRGHEIIRTKFPNLLKDVDENDPAAWFEEFAAAQLPSDLLESCPASQEKLITITRHLWELESLVRALDSIETLTSLAALTREESVPMTREMWQEVSQTVRIAKACMRPVLKEWLLTTYDGRSVEQDFLDIRQAYIPETILAYISCLHFAGTSLSRDNLLECMDLAAIIAEKDSDVAKEFMRCGRMKELVEAFASASKALAIWSGEKKGSQTNSKKLRELGWSRELWSIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0SES4</accession>
    <name>G0SES4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyanovirin-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0059530</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS17940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696271.1">
        <property type="nucleotide sequence ID" value="XM_006696208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SES4"/>
    <dbReference type="STRING" id="759272.G0SES4"/>
    <dbReference type="GeneID" id="18259991"/>
    <dbReference type="KEGG" id="cthr:CTHT_0059530"/>
    <dbReference type="eggNOG" id="ENOG502RD2M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144960_0_0_1"/>
    <dbReference type="OMA" id="RIGCYTH"/>
    <dbReference type="OrthoDB" id="4672515at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.60.10">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011058">
        <property type="entry name" value="Cyanovirin-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036673">
        <property type="entry name" value="Cyanovirin-N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08881">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51322">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409513" description="Cyanovirin-N domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Cyanovirin-N" evidence="2">
        <location>
            <begin position="41"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="153" mass="16773" checksum="60F55253BCAF49A6" modified="2011-10-19" version="1">MVSLACIVQAITVILTVFTSPTGGQITNGGFASFCAFTGAILVDGHLLGMYCENNDIAIFGYNYTWIDLDYCIGNYIGMLRPQEFGHYSASCRGCIINFDSTLWLDCICPDLRHLPVHSTIDLNTTLFDYDGALGCFRVLGNKTREGPPLPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0SES5</accession>
    <name>G0SES5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oxidoreductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0059540</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS17941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696272.1">
        <property type="nucleotide sequence ID" value="XM_006696209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SES5"/>
    <dbReference type="GeneID" id="18259992"/>
    <dbReference type="KEGG" id="cthr:CTHT_0059540"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_4_3_1"/>
    <dbReference type="OMA" id="AAYQMSQ"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF26">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_4G05870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS17941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="275" mass="30756" checksum="C2F24453D68CBA5C" modified="2011-10-19" version="1">MTDKGQFERGHEIPISKQDFPGLETKMPYPRPLFDEIPTDDGKSQKYKAAGKLKGKHAIITGGDSGIGRATAIIFAMEGADSLITYLPEEEDDAQETKKRVEAYGQACFLLAIDLRDSRNCRRVVDEAVRAWKGIDILFNNAAYQMEIEDISQLSEEQWLNTFNTNIHPYFYLAKYALPHMKRGGTIINNASINAYVGRPDLLDYTATKGAIVSFTRGLSNQQIGKGIRVNAVAPGPVWTPFIPATMTEEKQKQFISPMGRPARKDLRILQDLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEU4</accession>
    <name>G0SEU4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable beta-glucosidase btgE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Beta-D-glucoside glucohydrolase btgE</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Cellobiase btgE</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Gentiobiase btgE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0059730</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS17960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696291.1">
        <property type="nucleotide sequence ID" value="XM_006696228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEU4"/>
    <dbReference type="STRING" id="759272.G0SEU4"/>
    <dbReference type="GeneID" id="18260011"/>
    <dbReference type="KEGG" id="cthr:CTHT_0059730"/>
    <dbReference type="eggNOG" id="ENOG502QS0R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027285_2_0_1"/>
    <dbReference type="OMA" id="VVCPYAT"/>
    <dbReference type="OrthoDB" id="4082933at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF24">
        <property type="entry name" value="FAMILY 17 GLUCOSIDASE SCW11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409120" description="Probable beta-glucosidase btgE" evidence="14">
        <location>
            <begin position="20"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="65"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="237"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS17960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="552" mass="56951" checksum="55A1C8A7F31BDDB7" modified="2011-10-19" version="1">MKKAAVLAAAAALAGSASASRHGHRNVHRHLAKKDLSTGLATADVCVPTCTTIYSTIYGEATILPPAETPKPSPSPVPETTAAPAPPPSEPATVPTPIVTTCETTGVYTFPATTIVLTETVTTCGASTTQVPSGTHTLGGVTTIVETATEIVCPVATTSTAPNGVVTSFVTETTYVCPTPGTYTIAPITVTVTEPSATVAVPTLTTYEPGTYTAPAVTTTITETNYVYVCPFTSEGVPAPSEPTSAPEPAPQAIEVPKPEPVTSQAPPPPAKTSTPISSGGPKKLGGGKHWAMTYTPFREDGTCKTAAEVSSDVAAIAGAGFKTLRVYSTDCDTLPNVGAAARANGLRMIVGIFIGAPGCDNGNPTVAAQISALKEWKQWDLVDLCVVGNEALFNGFCSVDQLAGLIQHVRSELSSVGYTGPFTTTDVVSAWLNNDVQPICQAIDVVACNAHAYFNAGTLPKDAGKFVAGQLAIVEKICGKTGYIMETGWPKAGNCIGVACAGPEEQRTAIHSIEEEVGSKAVFFSFRDDPWKAPGACNCEQHWGCGDVFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEW9</accession>
    <name>G0SEW9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0059980</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS17985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696316.1">
        <property type="nucleotide sequence ID" value="XM_006696253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEW9"/>
    <dbReference type="GeneID" id="18260036"/>
    <dbReference type="KEGG" id="cthr:CTHT_0059980"/>
    <dbReference type="eggNOG" id="ENOG502SW2Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038283_0_0_1"/>
    <dbReference type="OrthoDB" id="4120617at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="282"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="355" mass="37904" checksum="CEE2432E7F428379" modified="2011-10-19" version="1">MPADIPTTSELPGSEDNTTSSADLSTPDDGSSSNKKILIITLSTVLPVVALVLLCSLLYYFRSRRRHHQSLNGRNPFFRRGVSPIDDEEIATWKAPRNEKHAFHGATSGADTDLEADSAFAKETGVASSSPPNSSHTKNPSTGSTKKPPSVIIYSRPSLDHPSPYSALDKLSFEKNLPDTPILAKAPNARIGLTDESVPGDDPYIPPPKRQPSRLSKAPPPSYQPRRNGGHARARSSRSSTRSFASGGIGNDFYNSNNITSPATAPGSETDLASPMFGIGGQSQSQPQTPRQSCEGHVVRPSRSFSRTRYPQRRHSRVYSSSSVPPRVSLGDDGVVGGLSPPPARGRSGTVGGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G0SF23</accession>
    <name>G0SF23_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0060540</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696370.1">
        <property type="nucleotide sequence ID" value="XM_006696307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SF23"/>
    <dbReference type="STRING" id="759272.G0SF23"/>
    <dbReference type="GeneID" id="18260092"/>
    <dbReference type="KEGG" id="cthr:CTHT_0060540"/>
    <dbReference type="eggNOG" id="ENOG502QRXF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010063_1_0_1"/>
    <dbReference type="OMA" id="VQDCGHG"/>
    <dbReference type="OrthoDB" id="2506204at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010816">
        <property type="entry name" value="Het-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052577">
        <property type="entry name" value="VWA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905">
        <property type="entry name" value="NG37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905:SF11">
        <property type="entry name" value="TINC (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07217">
        <property type="entry name" value="Het-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409178" evidence="2">
        <location>
            <begin position="27"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="657"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="743"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS18039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="799" mass="89167" checksum="309C7554B6BE12CE" modified="2011-10-19" version="1">MATLKPFSSFLIGLLLFFCFVRPTLAFGAGNIASISSVEGQNWRHGDIEDALLKIVMARAVGGQRFDKLMVARVYFGNWLRDYSQAIDIGTVKFVSAEAIRLLLCILGFLTFGYGSREFEVTAERLGCYRPEDHIDNPKGYGEGQDPRQYDPRLRGPVDEETELAIDEETGMKNYIANEKIGIMTSAKHVRNLFGKCIELGREYGRSGNKDDLYEALRLLGTGLHCLEADFFAHSNYTELALIELGERDVFPHVGRNTKLRIPGTRGSVYPIVTGTFGGVDFLHSVTGEVSDKMIQSEIDDLEGMMKQYKNGDTSILRDLLDKIPDGLIGGKKDQLDDIQQNAQAAQVETLSISPRDPEEVTQYAQQVFAQIMPAIQFHDELLQDISRAINKVPILPKIIEQLEEQLSLWVFSIIAPFVIPLIEQIKNELQTGSSEIIESSKREQHIVFEDDDCSDPTHSMLSKDHFTNILNEIAGRTASKVVSWVVPQIMSAWDDEDLDVDSLLNKIIYGVLHHPAQRDMGPDGAEEGRQLIFESIRTWWEDELSESQREEYRRKLSREGVENGENHKEGQKDCGHGCGGKLKMKKNYRNEAPQTVEDKIAGAAAGAIVDGLKMSVADVAQGKITSGGTGSGFGSFLSSLTDNILSAGSKRFKEELGRFGKGEEEEEEEEKPSYSSGGYGGSSSGYGRKNDDEEEDEEERPSYGGYGRRRDDEEEDRPSYGGGYGGGYGRRDDDDDEERPSYGGGYDGGYGGYHRRRDDDEEEEERPTYGGGYGGYYRRRDDDEDEGYGGGRHHGWGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFD4</accession>
    <name>G0SFD4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GTPase-activating protein GYP7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">GAP for YPT7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0061650</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696481.1">
        <property type="nucleotide sequence ID" value="XM_006696418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFD4"/>
    <dbReference type="STRING" id="759272.G0SFD4"/>
    <dbReference type="GeneID" id="18260203"/>
    <dbReference type="KEGG" id="cthr:CTHT_0061650"/>
    <dbReference type="eggNOG" id="KOG2197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004457_0_1_1"/>
    <dbReference type="OMA" id="WWREQRG"/>
    <dbReference type="OrthoDB" id="10264062at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000032">
        <property type="entry name" value="GTPase activating protein (Gyp7)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000005">
        <property type="entry name" value="TBC1 domain family member 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF502">
        <property type="entry name" value="SMALL G PROTEIN SIGNALING MODULATOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="5">
        <location>
            <begin position="503"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="804"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="836"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="867"/>
            <end position="876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00072091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00082648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS18150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="884" mass="99154" checksum="1150E952095CA492" modified="2011-10-19" version="1">MTSSPPSAASDSVPEPSSLNDQQHTTATNTTPRTSSSSLAASTTPSSTATIIDRPPSPAGSLDAMSDDEENDYNTITHTEPPTTRGVKLLFCKSKVYVHPTPSARDNVPGYIALLQQKPSPLTTSLDSEPSSRTNPSSADLLLAWIPDSQLGAAAPTYAKVDMNIDSDSPPRLAHLVPPIPIVTSHPGNSSASPYIPSRNSLAYGHSPFAIPLSAIFSILLRPPSPGWWHGSIVINVRGGESFPPLFFHDNECASTMAQKRKRTHERFDPFGEDGEVFWGGDEVMRWVRRYVRVERSGVENGVWLIEPSKEDSEAFGAGALGGKGLVGGRRGSTSRAGPSNAAAGAGRGGGGIDPLMKFVKEAGWNIMEKFSKVTTFTRQAAQDVLDNPRMPPQVRRLLRNPEVQTLQEEFDSARIYLARWAMGIAEQSERERSQRIWTAREVMELENTDVGEFELLERANSLTLEEARKPVTLKEWIGYFDPHTGQLLVTVDEVKERIFHGGLDPDVRKEAWLFLLNVYDWYSTRDERKAQAASLRDAYLKLKASWWERQIDLGGQGEEGEWWREQRGRIEKDVHRTDRNVPLFAGEDIPHPDPDSPYASVGTNVHLEQMKDMLLTYNEYNKDLGYVQGMSDLLAPLYAVLQDDALAFWAFKGFMDRMERNFLRDQTGMRAQLTALNHLVQFMDSALYKHLEKAESTNFFFFFRMLLVWYKREFKWADVLRLWEALWTDYLSSQFHLFVALAILEKHREVIMEHLERFDEVLKYINELSGTMDLESTLIRAEALFKRFQRLVDAVDKKSNFPAPRPLFSPSPSSSQQSVASTGSNAGGKLPSQAPGLSQKEQQPNQSERVITPELRKLLSRQWEPVPHKDGDKGKGKGMGMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFQ1</accession>
    <name>G0SFQ1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0071690</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697434.1">
        <property type="nucleotide sequence ID" value="XM_006697371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFQ1"/>
    <dbReference type="STRING" id="759272.G0SFQ1"/>
    <dbReference type="GeneID" id="18261207"/>
    <dbReference type="KEGG" id="cthr:CTHT_0071690"/>
    <dbReference type="eggNOG" id="KOG4411">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037269_6_3_1"/>
    <dbReference type="OMA" id="MINAREQ"/>
    <dbReference type="OrthoDB" id="270318at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS17816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="395" mass="44443" checksum="F7B31F86222628B7" modified="2011-10-19" version="1">MRFMRHLGNVLWHRASLRVDQACSPIAINARNYSTNIAAPSDADIDSARKYCVNQLKHGDYEAYLIRHFLPPPAQDAYDALRTLNLELSRMPEAVSNPTLGRMRMQFWRDAISNTFDGRPPREPISVLLHRSITKLKERAGPGSVGSLKFWLLRFLSTREQHLDNRPFANLNALEEYAENTYATLMYLTLASIPIQSVHMDHLSSHIGKACGIVAILRSIPVLTMPPRPVENPSGSLVGSSRPPALLLPLDVMAKVGLKEEDVFRQGPHAEGLQDAVYQVATRANDHLITVREMLKNLQSGQGPGHNYEHQHEAEHVHTSPAQDTQDIAVEIRRGFGVLLEAITAHSYLKSLEGSNFDPWRVKRSWRLPWSLWKAAKRRSAALAREPGMTLDWGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFY8</accession>
    <name>G0SFY8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Indoleamine 2,3-dioxygenase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0072620</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697521.1">
        <property type="nucleotide sequence ID" value="XM_006697458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFY8"/>
    <dbReference type="STRING" id="759272.G0SFY8"/>
    <dbReference type="GeneID" id="18261300"/>
    <dbReference type="KEGG" id="cthr:CTHT_0072620"/>
    <dbReference type="eggNOG" id="ENOG502QV6W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010089_0_1_1"/>
    <dbReference type="OMA" id="WHQYSGG"/>
    <dbReference type="OrthoDB" id="540174at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF10">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS17903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="488" mass="54778" checksum="07883BA3B150CE2A" modified="2011-10-19" version="1">MSPTECDPLIKRKRKLGDLPLAELPDPLRDFAVTKNGFLPENGPLKRLPDAYYAPWEDLIERLSALIENNTLRQKVDKLPVLSVEHLKTEAEWQRAFVILGFLTHGYIWGGDAPAQILPPPLTVPLLAVSSHLGMPPVATYAALNLWNFGTTSPSNNFADLDNLYSLHTFTGTRDESWFYSVSVAIETAGAELIPVMMNALEEVFCVMNKPYPVETNFEGYKKAIGMATSALRGLCKRLGELGALLVRMDEHCDPAIFYHRIRPFLAGSKNMASAGLPRGVFYKEGEGKGSWRKYRGGSNGQSSLIGFLDLVLGVEHRYSVYERGDLKPAQETHIEENEDKKQAFHDEVREYMPAPHRRFLEYLEDRYPGGMRTAVERLMGNYSGKSEKDVSNELEELWKAFQSAIKAMVDFRSHHLQMVARYIIIPSRQHRQCDGSKVNLATASSIQRSDQDKTELTGTGGTALLPFLKQSREETLQAGNLSIEVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFY9</accession>
    <name>G0SFY9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HPP transmembrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0072630</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697522.1">
        <property type="nucleotide sequence ID" value="XM_006697459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFY9"/>
    <dbReference type="STRING" id="759272.G0SFY9"/>
    <dbReference type="GeneID" id="18261301"/>
    <dbReference type="KEGG" id="cthr:CTHT_0072630"/>
    <dbReference type="eggNOG" id="ENOG502S3SU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040397_0_1_1"/>
    <dbReference type="OMA" id="PLYWWTS"/>
    <dbReference type="OrthoDB" id="2016548at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007065">
        <property type="entry name" value="HPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058581">
        <property type="entry name" value="TM_HPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33741">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33741:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04982">
        <property type="entry name" value="TM_HPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="HPP transmembrane region" evidence="3">
        <location>
            <begin position="51"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS17904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="293" mass="32667" checksum="263C6154A9487ECA" modified="2011-10-19" version="1">MGLSPYRGPYTWHFDIDTYLNPILPPSILPSLPSYISHFLGYRTHPPRPLGNLVMVLWAAIGVFCSLAIIGAVSINIPSIQAHGTPTVLGSYGAAAVLSFYAIESPLSQPRNAILGQIISAVTGIIIHNLFSLSPHFAAIRWLGASLALCLSCGLMLCVALLVNNVQRRFPFYWWSPQETGSFWRRAKVDIERETGRPDTVDRSERRLREKKEYSGRGEQQAEEELTSSSGDLELGRRVARSVSLEHGREGEIVIRRGRVRLPDGLMLRPEELLFLETLGERLGHLGHSEKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGK4</accession>
    <name>G0SGK4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospholipase/carboxylesterase/thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0066650</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696961.1">
        <property type="nucleotide sequence ID" value="XM_006696898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGK4"/>
    <dbReference type="GeneID" id="18260703"/>
    <dbReference type="KEGG" id="cthr:CTHT_0066650"/>
    <dbReference type="eggNOG" id="KOG2112">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062889_1_0_1"/>
    <dbReference type="OMA" id="VMQFFAR"/>
    <dbReference type="OrthoDB" id="437457at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF67">
        <property type="entry name" value="PHOSPHOLIPASE_CARBOXYLESTERASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_5G09340)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="3">
        <location>
            <begin position="41"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS17343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="286" mass="31075" checksum="3572A30DC44558E5" modified="2011-10-19" version="1">MGRPPTTQDFLPILPSHPAYRPPPNSPPPTTCEPWITLIPPPSPPIRAILILLHGLGDTERPFAHVARNLSLPGVFCISLRGVSRLPSFLLPPGPADPSGQGGPEGFHWGDDLKFSAKGLDDDPGFAKAREWIVEKVIGQVLVGECKFEWGEVMMFGFGQGGSVALGVARGLEVSARVVDVTEGEKKDVNKRRTLKGVVSIGGALPPSMVPSVSARLKAKVPVLVCCGRQSQAVDEDAVDTLEEEFEKVKVVRWNKPDDGMPQNRDEMLPVMEWFADRLRGPSPWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGN4</accession>
    <name>G0SGN4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0066970</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
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    <feature type="chain" id="PRO_5003409229" description="Peptidase A1 domain-containing protein" evidence="8">
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            <begin position="19"/>
            <end position="463"/>
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            <begin position="137"/>
            <end position="459"/>
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            <begin position="103"/>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
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    </evidence>
    <sequence length="463" mass="49973" checksum="94D9E2860B734518" modified="2011-10-19" version="1">MRFSLLAAAAALLSPAFAAPRVVKVDPKDIKPRHPGGIHFKVAQVHNDHFRQHGKGPRALAKVYQKYDVKMPTSLLRVLRTIYDEIEHPSNDDDPSGYAAGDGSYGGGGAGGDDSDTPRVPDTGEVTAIPQLFDVEYLAPVEIGTPPQTLMLNFDTGSSDLWVFSSETPARYVAGQKLYQIENSTTATRLANHTWAIQYGDGSRSAGNVWLDTVSIGGIAVDRQAVESATSVSSSFTRDNASSGILGLAFDHLNQVRPNKQKTWFSNALDVLEMPVFSANLKKAEPGNYNFGFIDTTEFLGPLHFVDVNSTDGFWKFEATGFSIQNANSTDNTSSLFVPVAHTAIADTGTTLLLLPSAITQAYYWQVANATDSPMLGGWVFPCGTYLPDLTLHIGTYKAVIPGELMVFAPVDTDDLATATTCYGGIQSSSGFPFAIYGDVFLKAQWTVFDMGEERLGFAAKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGQ2</accession>
    <name>G0SGQ2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0067160</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001514_1_0_1"/>
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    <dbReference type="OrthoDB" id="336088at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1366"/>
            <end position="1387"/>
        </location>
    </feature>
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            <end position="341"/>
        </location>
    </feature>
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            <end position="742"/>
        </location>
    </feature>
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            <begin position="795"/>
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        <location>
            <begin position="11"/>
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            <begin position="473"/>
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            <begin position="665"/>
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            <begin position="676"/>
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        <location>
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        <location>
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            <end position="1510"/>
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    </feature>
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            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1535" mass="169406" checksum="1F4977CF272B56C7" modified="2011-10-19" version="1">MGAKGQDPGLSSRSSKSSGGSSSSSSSSQHGPDPVSVPASATVHHQGYLIPTCYRSAVISVPKAARQSGARPRANERTNCSNDSVDCAMCQATYHMNCVRPPLLKKPSRGFAWSCAACSRARERELEARNTPNLADQQSILEADDDDAYDDEDEEMPDADAPRGLWSHQSLWPYRYLGMHCKAEDALDLDDRIFPRASTRLGLRHQAVVPPWYGRPVQYVKPTIDIKKGKGSSKLTKEQQAALEAERIRKEKRPKWIQDEPPGYVERGGDDTATLLFKPPEECGSSMTHDELDAYMDTARSMALSLGLPKYSTNLQDVARDILFRCNFDAKRALEELARTPKAEFKEPELTPAEQKKFEEGVAKYGSELHLVKKHVKTLSAATITRWYYTWKKTERGKQVWGNFSGRKGKKDAKKAEAAANKLADDVADDQDDSAFDTDKAKTLKKSFICKFCSTKKSRQWRRAPAGAMSPISEKESGSGKNGDKSKAGQGEKKEQYIQALCRRCAELWRRYAIQWEDVEEVAKKMAQNGGRGWKRKVDEDLYKELLAADEMMANTRYSTPESEKASPEREQKDSAREKTAASSEPPRKKLKSSVDKDKEKDKEKIKEEKDRDGDRAPSEAASSSSASNAASSSNKKKAAADKEKTAAAAAAAAAAAAAAAAAAAEREKEKEKQAPPAPAPPPMPEIPKPKTLPCAICHEMEPMGDQHLSCKECRLTVHRNCYGVVDNRAPGKWICDMCLNDKNPQLSIHYKCVLCPIEFTEHEFLDPPKISNSHKKKTDKERERERIERETYQRAIEYYRKKQEEMNRPINPHEPLKRTADNNWVHVTCAVWTAEIKFGNAKGLAPSEGIPLIPRARYEETCKVCKTRKGACVYCHHCHAPVHVECANQAGYVLGFDITPVKGSRRDQFRIVTIKGETGVMSAAVWCKDHVPTKTIVHRMYDIVDEATGMNALQLYVQNFKQADLTLTGCARKANQLSIASKQMANGSSSSSSSGSSGSAAHHHHHHHHHHHHQLNRRTSLAAVLNGDSSSSSYSSSHSTITNGVDTSLNPRHPWGKVCITCGVDVSPKWYPVDLTQEEVAQLSSEARKFVEQRSFQCHKCKKAGRQPTLQQPAKEPTPPPVLEPPRQPSQAPPVLPPLGPTPTEPRSHGHGRTPYAWGPPPTPGPGPNPGQPPPLLQAPAAGPLALPSIVQPGPQVPPPTLPPPLGARNPGVPPPPPPPPPNYGSRSYDWHRGPPPPPLHPTPREVNGNGPSPPPTSLPALAPPNHLRPLPSVPQTITLLTPRPPRRLLLLLLLGLTGTWQVRPRRSLMAYRNLLDTCRVPRRHRRHPPLLQVQDRAAHLHLISLRRRPITRAITAHSLPLRHLITTVIVTVILILALTPIPWLWAPTCINIIRKPWGPPPPPTTSGAGAPAVPPLRELRDLRDGVLPPPPPPPQPQAREYPEQGRYGPVEYEGHYPGEQGARYHAPPPPPPPPPPPPVPPPSQQHQLPPVREWDATREVRGDREQAREPVSQPVPPRPSGASASPSLRNLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0SH67</accession>
    <name>G0SH67_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">M7G(5')pppn diphosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0068900</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DCP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697174.1">
        <property type="nucleotide sequence ID" value="XM_006697111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SH67"/>
    <dbReference type="STRING" id="759272.G0SH67"/>
    <dbReference type="GeneID" id="18260928"/>
    <dbReference type="KEGG" id="cthr:CTHT_0068900"/>
    <dbReference type="eggNOG" id="KOG2868">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058649_2_0_1"/>
    <dbReference type="OMA" id="LFVCTQS"/>
    <dbReference type="OrthoDB" id="255837at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13182">
        <property type="entry name" value="EVH1-like_Dcp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010334">
        <property type="entry name" value="Dcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16290:SF0">
        <property type="entry name" value="DECAPPING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16290">
        <property type="entry name" value="TRANSCRIPTION FACTOR SMIF DECAPPING ENZYME DCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06058">
        <property type="entry name" value="DCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS17556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="215" mass="23662" checksum="ED5244842BD2F134" modified="2011-10-19" version="1">MVAAVCHARSARSAFPPRDNTELSLRVLRRYQPTIRTILAIAANAVAYSFLEASQSWEKHGAEGTMFVCDQDPVPTPTGQVLPRQCVFVLNRRSMDNLVIDLLRVTDCEVVGELIVFRFEDDTSQGEDGGREKKIIGLWIHADETNIREVYTSLILGAWQQARLAVDAYIQAMAGNPVSSSVEPTNPQPAASFTTTPLAGKRISVSDLFRQKNGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHN2</accession>
    <name>G0SHN2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0070640</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697339.1">
        <property type="nucleotide sequence ID" value="XM_006697276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHN2"/>
    <dbReference type="GeneID" id="18261102"/>
    <dbReference type="KEGG" id="cthr:CTHT_0070640"/>
    <dbReference type="eggNOG" id="KOG0691">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073392_0_0_1"/>
    <dbReference type="OMA" id="AKYDNHR"/>
    <dbReference type="OrthoDB" id="376357at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052094">
        <property type="entry name" value="Pre-mRNA-splicing_ERAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="22"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="149"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="215"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="340"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS17721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="361" mass="40150" checksum="ABB794A222AB6A03" modified="2011-10-19" version="1">MTSTVDRDLLQWARDAASRGEDLFALLGTDATATESDIRRAFRRRALTAHPDKAGANYDPALYEKLERARDTLLSKEARDVYEAEMRAVMQRKLERERMGEKRRRLVEDLERREEEALKRQKMGVQRQTEIDQEKAAMIARGRAKMEELRRLREEAEVRERLAREKEEREKGLSRSGTETPVPLAVEQGRTQGQKEQMHDASASAPASAADGDDYDARIAELERRLREKQEKKAAKRAQREAKKVGEDSSETPKEAAPELKDTTQPSQPPPAPSRPDSPAAAAPTASEPAQDKETTTTTTTTTTTSTSTSSSSSSSSSSNPPKASERFASTMARLRAAQAKREEEKRRKAEEAARAAAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHT7</accession>
    <name>G0SHT7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyl hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0073320</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697589.1">
        <property type="nucleotide sequence ID" value="XM_006697526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHT7"/>
    <dbReference type="STRING" id="759272.G0SHT7"/>
    <dbReference type="GeneID" id="18261370"/>
    <dbReference type="KEGG" id="cthr:CTHT_0073320"/>
    <dbReference type="eggNOG" id="ENOG502QTTU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021766_1_0_1"/>
    <dbReference type="OMA" id="EPYKNAI"/>
    <dbReference type="OrthoDB" id="4104179at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053169">
        <property type="entry name" value="MUG_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791:SF2">
        <property type="entry name" value="ENDO MANNANASE, GH76 FAMILY (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 191 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409279" description="Glycosyl hydrolase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="641" mass="71731" checksum="8747C3C46BFA38F8" modified="2011-10-19" version="1">MHLVWAVVTLSATAVLAWPWATPPQRPAHDEARSCSSNCGSTLTDVSIFQDMLSALHNLQDVYFQRWVGTWPKGIDWTRAVMATHVAAALRTISDQLVRELKSDNKKADSHVTTTQLDTISLYFTDLVAYYFGEDAFAIRNQAYDDMLWVVLGWLESIQFVHNHGKLLAQYPSLRQSSPAAVDSNEWYGHRWIPAFAHRARVFWELAAKGWDTKLCGGGMIWNPRLLPYKNAITNELFIAASIGMYLHFPGDENDSPYTSNIKLEPPNISPNFGWHAHDPVFGSAAQRGHDWLRSSNMTNDQGLYADGFHVSGLGKEGNNNTRCDDRDEMVYTYNQGVILSGLLGLFQATGQEHYLHEGHALILNVIAATGWDLTRNKPLEPRAENLTFFLVREGKLPRWHGLGRAGILEDACDMRGSCSQDAQTFKGIWMHHFATFCAPDALEFVHPRAGLDEQTLERIRDEHAAQCKGYLPWLRRNAKAALGTRDENGLFGMWWTPGLLVAESGGRDSVLLMENVRVTDDALPPRKEGEVDYRNEGVPQDEVWMEIGHVFGQERELPPVVGEEGGQRPLGGSGRQMTLMVNGEKRNGTWSGILLRKDDVMGSIVFGRDPNVRGRGRTVETQGGGLAVLRALWVVSRNEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHW6</accession>
    <name>G0SHW6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0073620</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP4R2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697618.1">
        <property type="nucleotide sequence ID" value="XM_006697555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHW6"/>
    <dbReference type="STRING" id="759272.G0SHW6"/>
    <dbReference type="GeneID" id="18261400"/>
    <dbReference type="KEGG" id="cthr:CTHT_0073620"/>
    <dbReference type="eggNOG" id="ENOG502SBSZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024587_1_0_1"/>
    <dbReference type="OMA" id="PIPWLQN"/>
    <dbReference type="OrthoDB" id="341898at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015267">
        <property type="entry name" value="PPP4R2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16487">
        <property type="entry name" value="PPP4R2-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16487:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09184">
        <property type="entry name" value="PPP4R2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="50"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="239"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="329"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="401"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="417"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="462"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="480"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="506"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="536"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="557"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="596" mass="63988" checksum="1995E20765EF922F" modified="2011-10-19" version="1">MATETLDRETSEAILKQLARDGTMDYAQWPKLLPIVLVRIEEIARTEFRIPSLPPPHPAPPRPPSPRFLAPLPSPDPVDAPEQAQPQQQQRSDAGLSTTDGHPSSDSTLSTDHQQQSALDTLPKPIAAMLDEVLSALRDNFSQYPPHTIQRLAELVTEPRRHYRNLVPYLHALDRVVHVTSGANIYPLPPAVPDMSSLSLLSGGASNAGGLAALSFNNVGSDEALGGALLTPIPWAKNKANGTNSDDDETDSTDLDSPGPALPSSHVQYRPTGLLLEGRLSTESTETIEGPNGPGRIETVTVSVSMNGTLSAGTTGLSLLTGGTPLMPINQLNQPLTPPAIPGAQDEDNDVTMSEAGSEEKKDGPDDEEEAPHARGPPEIGVADTGPLNANIAKVIASTGRQDKKDEEQAQKEASDNKLSSPEATTASLIPRSPKREAEDSLEKITRKRLKEDEAPASPRPRHAEVPIKRKVELPREKVVGQNKGQQQQQQQQQQQQQQQQQQQQKQKEKEKESEKAEAQSENGKSAPSKKEDEQNQTQSSSGPDSQGDIVLPDRSASFEEAPKKEKPSDVGEVLKEGDGDKPKEESSIGAAAGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0SI19</accession>
    <name>G0SI19_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0074180</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697671.1">
        <property type="nucleotide sequence ID" value="XM_006697608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SI19"/>
    <dbReference type="STRING" id="759272.G0SI19"/>
    <dbReference type="GeneID" id="18261456"/>
    <dbReference type="KEGG" id="cthr:CTHT_0074180"/>
    <dbReference type="eggNOG" id="KOG3904">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018689_0_0_1"/>
    <dbReference type="OMA" id="IIMFPPQ"/>
    <dbReference type="OrthoDB" id="1695362at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18870">
        <property type="entry name" value="NUDIX_AcylCoAdiphos_Nudt19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039121">
        <property type="entry name" value="NUDT19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318:SF0">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE NUDT19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318">
        <property type="entry name" value="TESTOSTERONE-REGULATED PROTEIN RP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="7">
        <location>
            <begin position="13"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS17089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="353" mass="39247" checksum="0F1FDEA7EFC6D1E3" modified="2011-10-19" version="1">MLDAGKSKKPPAPVRPSASIILLSPTNQILLLHRVQNSSSFASAHVFPGGNLSEFHDAPLPKADSLDELHRDGLAYRLAAIRETFEESGILLARGKDGALLQLEDEVRDAGRKEVHGNKVRFGEWVTSVGGEPDVDNLIPFTRWITPAGPPKRFTTQMYLYMLPLSSSISSSSPDQTTETIIPTPTHDGGLEHTAATFAPVSTWLSRARKNDIILFPPQFFLLNLISPFLTSPSPRSTPSPDFYASQRTALLEFLQKIPTSKEDPSPLKTHLIPWSEKVISPTVMFVRQSDKRYVLGLDKPGPELRGSGRGGDWERVVLVDFRKEGPRDVEVRGRNEVLREEKEVKEKEEAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0RXU9</accession>
    <name>G0RXU9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0000460</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988030">
        <property type="protein sequence ID" value="EGS24115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690601.1">
        <property type="nucleotide sequence ID" value="XM_006690538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RXU9"/>
    <dbReference type="STRING" id="759272.G0RXU9"/>
    <dbReference type="GeneID" id="18254084"/>
    <dbReference type="KEGG" id="cthr:CTHT_0000460"/>
    <dbReference type="eggNOG" id="ENOG502S3SW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036837_0_0_1"/>
    <dbReference type="OMA" id="HTIDCSH"/>
    <dbReference type="OrthoDB" id="94039at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN LPX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="102"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS24115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="403" mass="45817" checksum="ACD35D6F80DB3336" modified="2011-10-19" version="1">MKFFRIVEHIVNGAHTREYATATVNGDADAGKIKLAVKQYIPLDNPNPQLGDELYEPLWDDLHQRLANSGVRIRSIWIADMWNQGQSGVLNEKLLGNDPSWWDNTRDILALITQKSDQMPHPLVGVGHSMGGAQLTLLALSNPRLFHSLILIDPIMQPLWSNSGIMPAIASTMRRDLWESRESAKAKFLQSKFYQAWDPRVFDLWVKYGLREIPTELYPAGSAPAGSVTLTTTKHQELFVFLRPTFRKTNGKIIDRDPETDKAPPKGYPFYRPEPVYAFKKLPEVRPSVLYIFGGKSDASTPDQRKLKLERTGSGLGGSGGAKEGRVKEVVLDCGHLVAMEKVGETADAISGWLKQEIQRWRNEQDDLQQRWVKVDRREKMIIDEEWKREVTPEVLRKKNPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G0RXW6</accession>
    <name>G0RXW6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0004540</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690994.1">
        <property type="nucleotide sequence ID" value="XM_006690931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RXW6"/>
    <dbReference type="GeneID" id="18254492"/>
    <dbReference type="KEGG" id="cthr:CTHT_0004540"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_5_1"/>
    <dbReference type="OMA" id="ETGWRWM"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005366">
        <property type="term" value="F:myo-inositol:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904679">
        <property type="term" value="P:myo-inositol import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000073">
        <property type="entry name" value="MFS myo-inositol transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF12">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="330"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="504"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="65"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS23752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="548" mass="59338" checksum="49007D3B4A04E833" modified="2011-10-19" version="1">MSSAEEPLIRRSRSPLADGRFQDDELNISSNNRSSSSHHHDPDYDDSHVPSKPVTFSSSLYIWLLTFSAGISGLLFGYDTGVISSTLVSLGTSLSPEPLTPLDKSIITSSTSLFALLITPFTSVMADRMGRRQVILLADAVFILGALIQAASHSVFAMTFGRSVVGMGVGAASAVTPLYLAELAPAAIRGQLVTMNVIFVTLGQVAAYVIGWLLGEYGGEDTAWRWMVGLGAVPAVFQAVIMVWMPETPRWLVMVGKAEQARRVVAKVLGGDDGKEVDAIVKAIEIEVREEREARRLRTIRGGPGRGDDTAGWVELLGELLRVKRNRRALAIACLLQGLQQLCGFNSLMYFSATIFAMLGFPVPTLTSLVVAVTNFIFTVAALFLIDRVGRRRILLWTVPLMVVGLLLAAWGFAFIDISQVFLTEPSTSDGPSNQTAAVTIVFAIMMYVAGYAMGLGNVPWMQSELFALNVRSLGSGIATATNWGANFVIGLTFLLLMEALTPSWTFVLYAAICAGGYWLIYRLYPETAGLSLEEAAALLEDDNWGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0RY73</accession>
    <name>G0RY73_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0005670</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691101.1">
        <property type="nucleotide sequence ID" value="XM_006691038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RY73"/>
    <dbReference type="GeneID" id="18254605"/>
    <dbReference type="KEGG" id="cthr:CTHT_0005670"/>
    <dbReference type="eggNOG" id="KOG0610">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_84_4_1"/>
    <dbReference type="OMA" id="HTGAPQI"/>
    <dbReference type="OrthoDB" id="432483at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05574">
        <property type="entry name" value="STKc_phototropin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000121">
        <property type="entry name" value="Serine/threonine-protein kinase nrc-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000078">
        <property type="entry name" value="Serine/threonine-protein kinase nrc-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45637">
        <property type="entry name" value="FLIPPASE KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="252"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="80"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="166"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="577"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="630"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS23859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="657" mass="72008" checksum="E3D631244051D5A0" modified="2011-10-19" version="1">MPSATKSTHGDGHFPQRLKNFFRITSGSRDRDSGSQAQLASQSYSSHSSNVTHHSSGNNNSSSTGSKLVAIRQTKFFSVGRSRSGTTASEGNPLEETLSPTAHANPYFQHQGQPALRHHEEGSVPPSPPDTPGIKIEGPDGGNAENVKASTKEELARKLRRVASAPNAQGLFKKGASGADKEPLPEGAIPAKDPKAAKNDEEEPPDGLEPASETRDALTPLPPPSQSNLAFRRTYSSNSIKVRDVEVGPQSFEKIKLIGKGDVGKVYLVREKKSGRLYAMKVLSKKEMIKRNKIKRALAEQEILATSNHPFIVTLYHSFQSEDYLYLCMEYCSGGEFFRALQTRPGKCISEDDARFYAAEVTAALEYLHLMGFIYRDLKPENILLHQSGHIMLSDFDLSKQSGPGGKPTMVLGKNGATSNGLPALDTKSCIADFRTNSFVGTEEYIAPEVIKGSGHTSAVDWWTLGILIYEMLYGTTPFKGKNRNATFANILREDIPFPDHAGAPQISNTCKSLIRKLLIKDENRRLGSRSGASDIKNHPFFRTTQWALIRHMKPPIIPHQGRNGIDTINFRNVKESESVDISNSRPMPPKRHDGSGAGGTPGSETPDPFEEFNSVTLLHDGDDDIPVVPDHEMERVRSELAAQQAAYSSGYGYQHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0RY91</accession>
    <name>G0RY91_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Maintenance of ploidy protein mob1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0005860</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691119.1">
        <property type="nucleotide sequence ID" value="XM_006691056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RY91"/>
    <dbReference type="STRING" id="759272.G0RY91"/>
    <dbReference type="GeneID" id="18254624"/>
    <dbReference type="KEGG" id="cthr:CTHT_0005860"/>
    <dbReference type="eggNOG" id="KOG0440">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038321_4_1_1"/>
    <dbReference type="OMA" id="VDNEQMF"/>
    <dbReference type="OrthoDB" id="8170117at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="235" mass="27125" checksum="45AE49F6A6F6C5ED" modified="2011-10-19" version="1">MSSFLTTVNNRTKNQFRPRAPGKGGATSYQLRQYAEATLGGGSLRKVVKLPEGEDENEWLAVNLVDFYNQINLLYGAITEFCSPQSCPEMKATDEYVLGIMSVMHCADEVRFEYLWQDSENYKKPTKMPAPAYIEQLMTWVQSNIDNEQVLPTRIGVPFPKHFPSLVRQIFKRMYRVYAHIYCHHYPVIRELGLEPHLNTSFKQYVLFIDEHNLATGKDYWGPLGDLVDSMLRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYD2</accession>
    <name>G0RYD2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0006270</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691160.1">
        <property type="nucleotide sequence ID" value="XM_006691097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYD2"/>
    <dbReference type="STRING" id="759272.G0RYD2"/>
    <dbReference type="GeneID" id="18254665"/>
    <dbReference type="KEGG" id="cthr:CTHT_0006270"/>
    <dbReference type="eggNOG" id="KOG1441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019048_3_0_1"/>
    <dbReference type="OMA" id="DAMSMIP"/>
    <dbReference type="OrthoDB" id="1588579at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="10">
        <location>
            <begin position="131"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="508"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="555"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="38"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="590"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS23918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="608" mass="65805" checksum="9D529369B8324B71" modified="2011-10-19" version="1">MAHSHLRASSQSRSPSRPSSSDYAKGETEKFPDFDSQAFPSLNGQTPSVPRWQQNGYLNGNGSIPNISQPPPDRWHARRDSRVRWAPGSSSSFGHGRKSSISNALHRLRSGSMSQNAHDLADALRAPFSWKLIVLCLMWYWSSALTNTSSKAILTAFDKPATLTLVQFGFVSSYCILFSWLASVFPRLRTAIPALKYPIRHPSKDVIRTTLPLALFQIGGHLLSSSATSKIPVSLVHTIKGLSPLFTVLAYRIFFDIRYPTSTYLSLIPLTIGVMLACSGNHQFGGQFLGIIYALLAAIIFVTQNIFSKRLFNEAARAEAESGPNGPLPRKLDKLNLLCYSSGLAFLLTGPIWFWTEGLDILGDFLWDGSVDLNQAPNSLDHGPLVLEYIFNGTFHFGQNILAFILLSMVSPVTYSVASLIKRVFVIIIAILWFRSPTTKVQALGIALTFLGLYLYDRSSAKNKADQRARALSASSKAAAAAPILPLSTKHIPVPSISSSSAFGVGAYGHGGHQRRPSALNNVSHNSDGSGSGSGSGYYYTTPGSAAAAKFSSGAGGIVDTKKNGRCDQGGGRQRGMSNAHAPLPPVGSRQEESWRVGDGKEIREKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYS2</accession>
    <name>G0RYS2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0007700</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS24058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691300.1">
        <property type="nucleotide sequence ID" value="XM_006691237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYS2"/>
    <dbReference type="STRING" id="759272.G0RYS2"/>
    <dbReference type="GeneID" id="18254808"/>
    <dbReference type="KEGG" id="cthr:CTHT_0007700"/>
    <dbReference type="eggNOG" id="KOG0789">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001645_11_0_1"/>
    <dbReference type="OMA" id="NIWPYDF"/>
    <dbReference type="OrthoDB" id="6058203at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01446">
        <property type="entry name" value="DSP_MapKP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18533">
        <property type="entry name" value="PTP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000051">
        <property type="entry name" value="Protein tyrosine phosphatase (Pyp1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF561">
        <property type="entry name" value="PROTEIN TYROSINE PHOSPHATASE 36E, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="6">
        <location>
            <begin position="308"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="562"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="835"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="171"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="671"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="804"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="881"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS24058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="990" mass="107777" checksum="04674E269BF047FE" modified="2011-10-19" version="1">MPPEQRQTERPSYFTIKTPGRLPAISPRGLSGLGDPSGSPSVLPKPKASPALSPSAGQRSKPYQATSNPDYFSLGTESNVDHKEPAFVTRENFRLTTAPVKPFSAAIPNQLPVEVNPEFETFRRQIEANCTRSTFTLSGTPFTLTSSASAPSLQKLALPRNRLQNRFHRPGVAENVQVLPQSSSDDFSSLSSKENSVSFGNQQEEVDGAGEQLRIRTPNLFSNEPSPVSSEPSPYACNLTRSQSVNFPLSKLSGPLSGLSLGGRSRVGSRASSASLHQPSLVEEAETTGGPTMISPVELRDLLEKDHDGTHVLLLDLRVSPQFARSRVRGALNLCIPTTLLKRATFDLQKLQQTFQVDRDREKFSRWRSTTHLVVYDASSFNKRDAISSVNMIKKFTNEGYTGSTNILRGGFNAFAAAYPGFVDHSEGGPPPSLSLGPIPNSSGASRPGVPPVIGGCLIPKGGNISNPFFDNIRQNQDLIDGVGQIQINLPPGLAQNSLPRWLREASEPGDAGKKVSEKFLRIEIAEQARMRDAYSFGQSRDVNVAPAGPKVQLSGIEKGTKNRYRDILPFEHARVKLQGRPEGACDYVNASHIRAKRSNKRYIATQGPLPATFEDFWSVVWDQDVRTIVMLTAETEGGQLKCDAYWKGNDFGPIQLRVLSEKKVSLEIDRHRSPRASPLGSHGSSPDISENARRRANTTTTLRSGIQTDKPFNFALPSAGPPSETPYVIIRKFALTHTSNPSAQVREVTQLHYPSWPDFGAPAQPSHLLALVELANTIEQGALPVDVPATLSASVSLAQQFGLRRPSGSAPPASDKAGSGSWTRSANWNVHGPENNANPRPMLVHCSAGCGRTGTFCTVDSVIDMLKRQRQHVMAKNMRQASLDGQVEQNAPSGVSPECDNATPSTSHTDTGDLDTAWLDDDTIDLIAQTVEDFRGQRLSMVQSLRQFVLCYETVLEWIARLQQQENGTAMAGTVAAMGGRSRSESFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYW2</accession>
    <name>G0RYW2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0000780</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690632.1">
        <property type="nucleotide sequence ID" value="XM_006690569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYW2"/>
    <dbReference type="STRING" id="759272.G0RYW2"/>
    <dbReference type="GeneID" id="18254116"/>
    <dbReference type="KEGG" id="cthr:CTHT_0000780"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_769470_0_0_1"/>
    <dbReference type="OMA" id="RTCELEC"/>
    <dbReference type="OrthoDB" id="4850684at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000003">
        <property type="entry name" value="Transposon Tf2-6 polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000003">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="10">
        <location>
            <begin position="85"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="11">
        <location>
            <begin position="194"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="318"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS23390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="41349" checksum="6E399036628B5921" modified="2011-10-19" version="1">MEDDHQLTHFTDLVTLKRDEGHFTQVKFEISSLVADHDVILTYWWLKEHTPSNFFGGDSLTFGSAYCRQNCVRSTYLSQQDAERATFQRMMNHIFDVLLDEGVLVYVDDILIYSRTMPEHDRLVREVLTRLQKHKLAVNAENSVWNVGEVEFLGYIITSHSLPKNQWSWTPEMQRAFDKLKAVSCEAPVLIHADPTKPFHLFTDASDYALGAVLNQEGDDGRLHPVGYHSRKMAPAEINYVIHDKELLAIVDAFKKWRRYLEGAPHTAQVYSDHNNLRYFLTSKVLNRRQTRWAQELAGYNFVINYIPGKKNIPADTLSRREQDRPEKGGSEDQSIATVSALVARGKADESLFRASPTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYZ3</accession>
    <name>G0RYZ3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0001100</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690663.1">
        <property type="nucleotide sequence ID" value="XM_006690600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYZ3"/>
    <dbReference type="STRING" id="759272.G0RYZ3"/>
    <dbReference type="GeneID" id="18254148"/>
    <dbReference type="KEGG" id="cthr:CTHT_0001100"/>
    <dbReference type="eggNOG" id="KOG0800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_619915_0_0_1"/>
    <dbReference type="OMA" id="FDIRFIF"/>
    <dbReference type="OrthoDB" id="4588272at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16469">
        <property type="entry name" value="RING-H2_RNF24-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969:SF69">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969">
        <property type="entry name" value="RING ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="366"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="38"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="174"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS23421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="419" mass="43773" checksum="1B5CEBCE31B869B8" modified="2011-10-19" version="1">MPNDTHLDWYCHSCHNEWQRIDDSTQCPTCRSLCTELITPDNDPRQFHRRGQSSNPPQSPDARPAADSAAGPGHDTNAQPAQSPTGAAGQGGTGTPGTGQGETGTPGTGQGGTGTSSTGTGQRIIFTVPLGVLVTFYAAQSPTTLLPTSPSDSSSPLSSVSYLLATLTLPSPPNSVASGQGAFAHPTESPIAETDSVTSASRQTQPGDRTEAPAPPTPSTPGITTTSTTAAHRQFIPTAQPTSDETPTADPHTPAHDDTEPHSSPPRQVLSLILALSLLTRTPLTPEEGAILRGDEPTTPAALHRILARLVEEAQVLAAQLQPAPIGGAPPASEAALERCLRPRKLEKELLGLETGDETKEEGVTCVVCVEEMRLGEEVAVLPCRHVFHGQCIGQWLALHNTCPVCRRSVEGDGAQKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZ21</accession>
    <name>G0RZ21_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pentatricopeptide repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0001420</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690691.1">
        <property type="nucleotide sequence ID" value="XM_006690628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZ21"/>
    <dbReference type="STRING" id="759272.G0RZ21"/>
    <dbReference type="GeneID" id="18254180"/>
    <dbReference type="KEGG" id="cthr:CTHT_0001420"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012630_1_1_1"/>
    <dbReference type="OMA" id="EMIYKEM"/>
    <dbReference type="OrthoDB" id="1908178at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="363"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="433"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="110"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS23449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="666" mass="75155" checksum="EF3D6573B41D1967" modified="2011-10-19" version="1">MRVSSRIDGSICGAILHVLYPPLSPLRPSPSLRSSAQSPSSCSSSRLPTASQQPRRCLSLLATRRRPSPLTLSSSSRRRLLLCVQALQTSRLRFDGDPAAVRVNHAAAATVENSGPEPEHEGYAAPEPQPLPSPSSSSPNPSTTTGPAITPQQPQTRKKQKHLKPIRRPLTKEELLALVDPYDDTEEIGRVEDYLQYLRDPYMRGYAEPEQPKVTLARTAEDEEYPSLEQVLEPADEGTRHVLWELRFAVLTRLRSPHKVDLDHIYELYQRLPEPRMLYLHARFRHQLLRALGQPDERDSASMLRYFAVIADVKNTGIPLTTAEWNCAIVFATKYVGRVTDVEVDTALKLWREMELEAGIRATDVTFNILFDVATKAGNFPLAEMIYREMESRGHRYNRYHYTSLIHFFGLKHDTSGMRAAYREMVEAGEIIDTVVLNAMISGLLRSGEEAPAERIYERMKALSLGPSSTNPFSPNSPPILPVRTPLSDRFITQALLMLSKLSRRHPHAQPHLQDMAPLAPDLQTYRILANHYGVKRGDLGRVAAYLDDMKHFHIPLHHSIFLALFKGFARHGGYPRSPWSEQRLEGIWNALLQALDAAQEGEGGIEVRTWLAIWCLRAFAKCAGSRERRVLEVYDVLKARWALSPEEEQFMGDFLSGLVNRGFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZ72</accession>
    <name>G0RZ72_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0001930</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690742.1">
        <property type="nucleotide sequence ID" value="XM_006690679.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0RZ72"/>
    <dbReference type="GeneID" id="18254231"/>
    <dbReference type="KEGG" id="cthr:CTHT_0001930"/>
    <dbReference type="eggNOG" id="KOG2286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_262133_0_0_1"/>
    <dbReference type="OrthoDB" id="190098at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051601">
        <property type="term" value="P:exocyst localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.50:FF:000006">
        <property type="entry name" value="Exocyst complex component sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.70:FF:000005">
        <property type="entry name" value="Exocyst complex component Sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.70">
        <property type="entry name" value="Exocyst complex component Sec6, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010326">
        <property type="entry name" value="EXOC3/Sec6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042532">
        <property type="entry name" value="EXOC3/Sec6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06046">
        <property type="entry name" value="Sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1020"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1060"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1106"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1141"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1180"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="6">
        <location>
            <begin position="972"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="763"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="764"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS23500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1292" mass="145928" checksum="E2978298A93EEF4B" modified="2011-10-19" version="1">MDVPPVKLSELLRHPDDLDKIAGLKAEFSRKKAAVDSQLRAGLREQLETAQAGMNGLVDGQKTVQQIKEEMIKIDRLCSESQNMIADFATINLVSQAHRNFGAVETMRRNLETFNDRLAAINDMLRQDDEDAENMPNLLAVHYELTQLRNIRDDAMEQIQRADDPGLQATLEDYFSRLDEAIAWFDDHIDLIARSLINLVIADNTSLVVRFALVIEAEERSDQRVLALQEALKDHKEMAVRFQSITDGAKTVRGYKDRFLGAIRKIGESQFEQTRAEFMDDPGALEKSLRWYFNDLNTVRLGMVQLMPKKWKIFKTWTNIYHTMMHDFLIGLIDDPQTTSSHTLEIVGWPEKYYRKMGKLGFKQDELTPHVIDNRETELVRDFRQLIIKFLDEWIGRIQAQERKDFADRTVEGANLDQDEYGYFRTKNLVDLWRMLRGQLDAAANSKRADVAEGVVDAMFQRLRQRQQNWQKMLEEEAAKYESGKVTELDGFGPLQDWLVATANDQIACIDDADEGDPEGAGGGRVAYLTDFRRKFAPLVSPAYMDRAEAEVAALRDGYLDLATWCMTKFAQLIFVVDFKSVMPDFFTPRWYTTTHMARMAATLDEYIADYRQVLHHSLVDIFVEILADELLVRYLSAVRNKGAKFRRTDQFQDKIYDDLKTAFDFFNALPNPALANSIKETWRVTEPFLQLLSVEKEAVPDTFAAFKTAYWDLQISWVEAVLRARDDFDRAMLNAVKSRAAQMDVVRGPETIMSKVYPSTKYSTTADSTTSLDLTPATESSTSLLLPRPAPPSASWKPRHAKHTKTVLEAVADTLPPCARRCVIEITLQREGAKVACSTPSTGNNLAPRRAPAFSDSHDDTRDLFDNSKHPYVHVSSLDDVDAVYGSRTADRDWDVCGGRGKGDGEVLRGVGVLGRSDDVDEASEPGIDAAARECLCGNGTEVEDGSRSLGRLFYATALTETRSSSAASNRRTSNYDWIMGLAMILYVPFEIVGSFAAHRGIGVDIWTVEASSMTRTMMFIYIAETLYLAILALTKLSILCFYLRVFPQHRFRILTMAVMGWIALSGIIFVFLQLFQCVPINYIWEEWKRGPFGQHRCLDINKASYAAALSSIAQDVVILIMPLPLLWKLRISWRDKASAIAMFSIGFFVTVTSCIRLRAMHPFGNSPNPTWDYTDAAIWTGIEVAVSIIVPCLPPIRAFAKWQRGKMNRSLEAATHAPEPASRPRHMRSVAGSIPHGVCKVPFLDAGGSGIREPQGYATMYERDMRMNNRLSAVESSDELLQALEPKGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZ99</accession>
    <name>G0RZ99_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U three protein 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0002210</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2017" name="Nat. Struct. Mol. Biol." volume="24" first="954" last="964">
            <title>3.2-A-resolution structure of the 90S preribosome before A1 pre-rRNA cleavage.</title>
            <authorList>
                <person name="Cheng J."/>
                <person name="Kellner N."/>
                <person name="Berninghausen O."/>
                <person name="Hurt E."/>
                <person name="Beckmann R."/>
            </authorList>
            <dbReference type="PubMed" id="28967883"/>
            <dbReference type="DOI" id="10.1038/nsmb.3476"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.20 ANGSTROMS)</scope>
    </reference>
    <reference evidence="14 15 16" key="3">
        <citation type="journal article" date="2019" name="Mol. Cell" volume="75" first="1256" last="1269.e7">
            <title>Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration.</title>
            <authorList>
                <person name="Cheng J."/>
                <person name="Bassler J."/>
                <person name="Fischer P."/>
                <person name="Lau B."/>
                <person name="Kellner N."/>
                <person name="Kunze R."/>
                <person name="Griesel S."/>
                <person name="Kallas M."/>
                <person name="Berninghausen O."/>
                <person name="Strauss D."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="31378463"/>
            <dbReference type="DOI" id="10.1016/j.molcel.2019.06.032"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.50 ANGSTROMS)</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690769.1">
        <property type="nucleotide sequence ID" value="XM_006690706.1"/>
    </dbReference>
    <dbReference type="PDB" id="5OQL">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="F=1-558"/>
    </dbReference>
    <dbReference type="PDB" id="6RXT">
        <property type="method" value="EM"/>
        <property type="resolution" value="7.00 A"/>
        <property type="chains" value="UG=1-558"/>
    </dbReference>
    <dbReference type="PDB" id="6RXU">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.50 A"/>
        <property type="chains" value="UG=1-558"/>
    </dbReference>
    <dbReference type="PDB" id="6RXV">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.00 A"/>
        <property type="chains" value="UG=1-558"/>
    </dbReference>
    <dbReference type="PDB" id="6RXX">
        <property type="method" value="EM"/>
        <property type="resolution" value="7.10 A"/>
        <property type="chains" value="UG=1-558"/>
    </dbReference>
    <dbReference type="PDB" id="6RXY">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.70 A"/>
        <property type="chains" value="UG=1-558"/>
    </dbReference>
    <dbReference type="PDB" id="6RXZ">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.40 A"/>
        <property type="chains" value="UG=1-558"/>
    </dbReference>
    <dbReference type="PDBsum" id="5OQL"/>
    <dbReference type="PDBsum" id="6RXT"/>
    <dbReference type="PDBsum" id="6RXU"/>
    <dbReference type="PDBsum" id="6RXV"/>
    <dbReference type="PDBsum" id="6RXX"/>
    <dbReference type="PDBsum" id="6RXY"/>
    <dbReference type="PDBsum" id="6RXZ"/>
    <dbReference type="AlphaFoldDB" id="G0RZ99"/>
    <dbReference type="EMDB" id="EMD-10051"/>
    <dbReference type="EMDB" id="EMD-10052"/>
    <dbReference type="EMDB" id="EMD-10053"/>
    <dbReference type="EMDB" id="EMD-10054"/>
    <dbReference type="EMDB" id="EMD-10055"/>
    <dbReference type="EMDB" id="EMD-10056"/>
    <dbReference type="EMDB" id="EMD-3847"/>
    <dbReference type="SMR" id="G0RZ99"/>
    <dbReference type="IntAct" id="G0RZ99">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0RZ99"/>
    <dbReference type="GeneID" id="18254259"/>
    <dbReference type="KEGG" id="cthr:CTHT_0002210"/>
    <dbReference type="eggNOG" id="KOG1272">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022996_1_1_1"/>
    <dbReference type="OMA" id="EFLPYHW"/>
    <dbReference type="OrthoDB" id="10251154at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000378">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012952">
        <property type="entry name" value="BING4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040315">
        <property type="entry name" value="WDR46/Utp7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085">
        <property type="entry name" value="WD-REPEAT PROTEIN BING4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08149">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01033">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="13 14 15" id="KW-0002">3D-structure</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="296"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="BING4 C-terminal" evidence="10">
        <location>
            <begin position="384"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="533"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="533"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00076453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS23527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="5OQL"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="6RXT"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="6RXU"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="6RXV"/>
        </source>
    </evidence>
    <sequence length="558" mass="63525" checksum="BFC2A3E39F4A6D6F" modified="2011-10-19" version="1">MDTSEAVDLAPAPAKQGRQANGAHSIANARTEFRSKAELDRIRRYKQAQKKYGRGPRVDIKSVRDKKLRRTLTNLENKYKTAALKAKEAEILLENQTGFLEPEGELERTYKVRQDEIVKEVAVEVAQKKFELKLTELGPYTCEYSRNGRDLILAGRKGHVATMDWREGKLGCELQLGETVRDARFLHNNQFFAVAQKKYVYIYDHNGVEIHCLRKHVEVSHMEFLPYHFLLATLSISGQLKYQDTSTGQIVAEIATKHGTPVSLTQNPYNAILHIGQQNGTVTLWSPNSTDPLVKLLAHRGPVRSLAVDREGRYMVSTGQDNKMCIWDIRNFKEAVNSYFTRAPATSVAISDTGLTAVGWGTHTTIWKGLFNKERPVQVKVDSPYMTWGGQGQVVERVRWCPFEDILGIGHNEGFSSIIVPGAGEANYDALEVNPFETKKQRQEGEVKALLNKLQPEMIALDPNFIGNLDLRSEKQRQAERDLDQPAQDIVEELRKKARGRNTALKKYLRKQRKKNIIDEKRLKAEELYRQMQEKRDGQTKEKQAEVGPALARFVRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZC3</accession>
    <name>G0RZC3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Life-span regulatory factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0002460</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690793.1">
        <property type="nucleotide sequence ID" value="XM_006690730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZC3"/>
    <dbReference type="GeneID" id="18254284"/>
    <dbReference type="KEGG" id="cthr:CTHT_0002460"/>
    <dbReference type="eggNOG" id="ENOG502S7ZU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099513_1_0_1"/>
    <dbReference type="OMA" id="CLVCDRQ"/>
    <dbReference type="OrthoDB" id="2563506at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024368">
        <property type="entry name" value="Ecl1/2/3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12855">
        <property type="entry name" value="Ecl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="15600" checksum="AEDA1D1C000B3AF3" modified="2011-10-19" version="1">MSFDWDNQYCLGCDRMTDGAAYCSEKCRLADYDKSSPSTPSSSASSPAPSSPAFNWTFSSPSSTSNKLYLSPAYDFQPSTSRRGSTGYPTLSPSASHSSLCSIRSSSSAGLDAQQQLSENAARELRAYAHSFESVRLQRRRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZI8</accession>
    <name>G0RZI8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">uS12 prolyl 3,4-dihydroxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0003110</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + 2-oxoglutarate + O2 = [ribosomal protein uS12]-(3S)-3,4-dihydroxy-L-proline + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54160"/>
            <dbReference type="Rhea" id="RHEA-COMP:13817"/>
            <dbReference type="Rhea" id="RHEA-COMP:13818"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:85428"/>
            <dbReference type="ChEBI" id="CHEBI:138052"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[ribosomal protein uS12]-L-proline + 2-oxoglutarate + O2 = [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54156"/>
            <dbReference type="Rhea" id="RHEA-COMP:13816"/>
            <dbReference type="Rhea" id="RHEA-COMP:13818"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:50342"/>
            <dbReference type="ChEBI" id="CHEBI:85428"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690858.1">
        <property type="nucleotide sequence ID" value="XM_006690795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZI8"/>
    <dbReference type="STRING" id="759272.G0RZI8"/>
    <dbReference type="GeneID" id="18254349"/>
    <dbReference type="KEGG" id="cthr:CTHT_0003110"/>
    <dbReference type="eggNOG" id="KOG3844">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017005_0_0_1"/>
    <dbReference type="OMA" id="GWYHIPQ"/>
    <dbReference type="OrthoDB" id="430522at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031543">
        <property type="term" value="F:peptidyl-proline dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009896">
        <property type="term" value="P:positive regulation of catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010604">
        <property type="term" value="P:positive regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006449">
        <property type="term" value="P:regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000014">
        <property type="entry name" value="Prolyl 3,4-dihydroxylase TPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.20">
        <property type="entry name" value="Oxoglutarate/iron-dependent oxygenase, C-terminal degradation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019601">
        <property type="entry name" value="Oxoglutarate/Fe-dep_Oase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043044">
        <property type="entry name" value="TPA1/Ofd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039558">
        <property type="entry name" value="TPA1/OFD1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051842">
        <property type="entry name" value="uS12_prolyl_hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117:SF0">
        <property type="entry name" value="PROLYL 3-HYDROXYLASE OGFOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13661">
        <property type="entry name" value="2OG-FeII_Oxy_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10637">
        <property type="entry name" value="Ofd1_CTDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="14">
        <location>
            <begin position="142"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="474"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="621"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="490"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="621"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00081607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS23616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="664" mass="74287" checksum="DD7443A6CB3C99DB" modified="2011-10-19" version="1">MKRKAEGSSSDGKKPIIKRAKSSLSPEDAKARFSKGLFDRADEFAAQYAKSWPYKHCVISELVDDALLRKVRDEIKANVHFTPKETDIYKIHQSGDLANLDGLEDEALAKLPSLLALRDALYSKTFRDFVSHITGCGPLSGRKTDMAINVYTPGCYLLCHDDVIGSRKVSYILYLTDPETPWQPEWGGALRLFPVIDREGKDGEVAKTPLPDVVKVIPPAWNQLSFFAVQPGESFHDVEEVYHASTPEELEKNAGRIRMAISGWFHFPQPGEEGYVEGAEEKAAHKSGLMQLQGNPDQHDRPLPNPVEVEKIVAKEGDDFPLDEADLEFLLKYISPTYLVPDTIDNIADQFEEEFSITLADILHPKFAAKLRKYIEEQEAKPLPEDSEKLEKTGPWKVAVPPHKHRYLYMQPGKQEIEPSPLKELLEVLLPSRQFRVWLQMATRSTIESYDLVARRFRRGQDYTLATGHEGKPRLEVNIGLTPTDGWGDVNDDEDDDEEGESSEEEQASSSKKGKEPATNGKGKGKAKAVDADGDDEMKDVDDIVELEVGGHEVYMAGDEDDDGDAAIYKSSEDDDNILFFQAATWNKMTIVLRDSGTLRFVKYVSRSAKGDRWDISATFEIEEQDEAPGSDEEVEAGPSKAGNDDSEEEFQGFSDNDMGDESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZM1</accession>
    <name>G0RZM1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0003450</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690891.1">
        <property type="nucleotide sequence ID" value="XM_006690828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZM1"/>
    <dbReference type="STRING" id="759272.G0RZM1"/>
    <dbReference type="GeneID" id="18254383"/>
    <dbReference type="KEGG" id="cthr:CTHT_0003450"/>
    <dbReference type="eggNOG" id="KOG1492">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048898_0_0_1"/>
    <dbReference type="OMA" id="CKRFTST"/>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000035">
        <property type="entry name" value="CCCH zinc finger protein, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46156">
        <property type="entry name" value="CCCH ZINGC FINGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46156:SF1">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="245"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="301"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="328"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="245"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="301"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="328"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="382"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="395"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS23649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="444" mass="49203" checksum="7DFE6B49E4AF5975" modified="2011-10-19" version="1">MATEEEREMMERIKRLTDQIQLHKSQQQAAAAAGQNPPPYYRSHHHPGYPSSWRRGGFPHRGGHSGARMPLYRNKTLILNRGPQQNQQTATAEADSGATSDASTTSWITKTDRHLQLINASVYKNSIQARTAALEQTRRQKAAFRDKQERAKLISHLNRMANSGGFGQTNSQAPAEQKYEVTVQGIRFVVAKNGSKLVRVPGDVNSPKATPKMAVIGGVKFYRSKNGNLYRHGVVKAQRQSGAVKKVNVPCKQFSMTGVCNQGPRCRYIHDPHKVAICKDFLLQGDCPNGEHCDLSHDPTPERMPTCLHFARDSCTKSDCKYVHVKLSPTAKVCHDFGFYGYCVKGASCPDRHAFECPDFSNTGVCKNKGCKLPHRERASMLRTRGLGSGSGGGAEDDEKMEDVSSDDESIDSDDVDSDEVDEFIGQDETGGLDFVEQRDFIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZN2</accession>
    <name>G0RZN2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcriptional activator HAP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0003560</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NFYA/HAP2 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690902.1">
        <property type="nucleotide sequence ID" value="XM_006690839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZN2"/>
    <dbReference type="STRING" id="759272.G0RZN2"/>
    <dbReference type="GeneID" id="18254394"/>
    <dbReference type="KEGG" id="cthr:CTHT_0003560"/>
    <dbReference type="eggNOG" id="KOG1561">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045001_1_0_1"/>
    <dbReference type="OrthoDB" id="1097733at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001289">
        <property type="entry name" value="NFYA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12632">
        <property type="entry name" value="TRANSCRIPTION FACTOR NF-Y ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02045">
        <property type="entry name" value="CBFB_NFYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00616">
        <property type="entry name" value="CCAATSUBUNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00521">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51152">
        <property type="entry name" value="NFYA_HAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="220"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS23660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="335" mass="36628" checksum="4A4B2A6ECA87AF6B" modified="2011-10-19" version="1">MMEYAQYQQQPQTAHSQPHIQTGYPSSTGGNNITSPSTQHLSQTSPILPSQQHQPSPTQTHNMYQTQYAVPQQNMHYGMPGIQAAAMAATAAASGSSYPYMPSDPSLQQSPRMSTVGAKKDARAGPRSPQQMNNIPQQRRMGQVASPGVPNAPTMLNHGGARPAVPPPMVAAQQMPPAQSPEMSSGAVEETPLYVNAKQFHRILKRRVARQKLEEALRLTNKGRKPYLHESRHNHAMRRPRGPGGRFLTAEEVQQMEKRKREEAEAAAKAAAEGSEQKEQQNEQQGEQQTQSEQQQQQEAGNKTPTGATKRKSDSSPSTASKKPKQGSDEGGDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2023-02-22" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZS0</accession>
    <name>G0RZS0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0003960</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690940.1">
        <property type="nucleotide sequence ID" value="XM_006690877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZS0"/>
    <dbReference type="GeneID" id="18254434"/>
    <dbReference type="KEGG" id="cthr:CTHT_0003960"/>
    <dbReference type="HOGENOM" id="CLU_1796257_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS23698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="144" mass="15531" checksum="84AFCB12F80D5627" modified="2011-10-19" version="1">MHLLINTIALASRKPGSPRQDIYQEFADLKRRGVGRLLEPVDVNVDDDKKNILFVTQVYPQPREEDLELIRAVTPSFSAAPTAGSVASSAGACAGVGLSFNEVILTSWLTLSQSLGCIPSLPVLLIREVPLPALPALPAWHAFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0D1</accession>
    <name>G0S0D1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Dipeptidyl peptidase 3</fullName>
            <ecNumber evidence="4 15">3.4.14.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 15">Dipeptidyl aminopeptidase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 15">Dipeptidyl peptidase III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CTHT_0009590</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity. Also acts on dipeptidyl 2-naphthylamides.</text>
            <dbReference type="EC" id="3.4.14.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 17">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15 17">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase M49 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.4" evidence="4 15"/>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691483.1">
        <property type="nucleotide sequence ID" value="XM_006691420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0D1"/>
    <dbReference type="STRING" id="759272.G0S0D1"/>
    <dbReference type="GeneID" id="18254997"/>
    <dbReference type="KEGG" id="cthr:CTHT_0009590"/>
    <dbReference type="eggNOG" id="KOG3675">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011977_1_0_1"/>
    <dbReference type="OMA" id="QRYWIRD"/>
    <dbReference type="OrthoDB" id="4694525at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000001">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000002">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000004">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005317">
        <property type="entry name" value="Dipeptidyl-peptase3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039461">
        <property type="entry name" value="Peptidase_M49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422:SF11">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE III-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03571">
        <property type="entry name" value="Peptidase_M49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007828">
        <property type="entry name" value="Dipeptidyl-peptidase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 15 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15 17" id="KW-0862">Zinc</keyword>
    <feature type="active site" evidence="16">
        <location>
            <position position="448"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="506"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR007828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR007828-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR007828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGS23292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="717" mass="79753" checksum="540DA6A1B1B7DAF2" modified="2011-10-19" version="1">MNAQELSQYLADAPPSVVRLEIEKHFNALSDKQKRYAHYISKASFAGNRIVLRQVSPESEHIYDFILSLYKASGGDWKALAKKAGVDEEGLTAFLHYAAQFLGNSGNYKSFGDSKFIPRCDESVFSALASTSPEAEKHYKATNGAIFATDKPGLLHLGFTDDGHMTTYYPDSPDITKDEISAVNKWMQDKGLLPENTRLRKTADGVYELLIASAKTAVPENGGDIGKETEFVVSEGVLAGKTIKLVYGDYSKEMEAITSYIRKAADNAENETQKKMHLAYAKSFEEGSLLAFKDSQRHWIRDQGPMVECNIGFIETYRDPAGVRGEWEGFAAVVNLERTRAFGELVQSAPSLIPKLPWSKEFEKDKFLSPDFTSLEVLTFCGSGIPAGINIPNYDDIRQQEGFKNVSLGNVLNAKLPDEKLPFLLESDIELFKKYRDAAFEVQVGLHELTGHGCGKLLQETSPGVYNFDIVNRPVSPLTGQPVTTWYKPGETWGSVFGGLAGAYEECRAELVAMHLSCEFETLKIFGFGDGTVDMDGVAGDVLYVSYIGMARAGLTAVEFWDPKSQKWGQPHCQARFAILKAMLQAEDNFCKLEYKKEDLSDLVIRVDRSKVLTSGRKAIANFLQKLHIYKSTADVEAGSKFFTEMSYVDPEFWGTKVRNVVLANKQPRKVFVQANTYLDEATGRVTIKHYDPTPEGMIQSWAERELEAANGTASRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0H2</accession>
    <name>G0S0H2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0010010</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the THOC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691524.1">
        <property type="nucleotide sequence ID" value="XM_006691461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0H2"/>
    <dbReference type="STRING" id="759272.G0S0H2"/>
    <dbReference type="GeneID" id="18255039"/>
    <dbReference type="KEGG" id="cthr:CTHT_0010010"/>
    <dbReference type="eggNOG" id="KOG1407">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045202_1_0_1"/>
    <dbReference type="OMA" id="WNADGRH"/>
    <dbReference type="OrthoDB" id="340259at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000870">
        <property type="entry name" value="WD repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040132">
        <property type="entry name" value="Tex1/THOC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3 THO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="79"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="218"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS23333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="339" mass="36787" checksum="611A33180436C16C" modified="2011-10-19" version="1">MAPPVRSRYSRIPKEKFSAYFGPLKSQPYNDSTSRGGSHHSLRTLAWNPLGTLIATGASDKTLRVWNPEKPNVRFSTELKGHTSGIEKIAFNPVKDAELCSVSNDGVVKFWDVRTKACVNEVKGLGNTHALAWAPDGSSLLVGNRAGELFQLLPTKSSVVSSHQQPVETNQMAFAWTGDKVFLPTNEGRVRILSYPGLEPVLHVNHAVKPDESTEFTLKGHTAPCLTVELSPTGRYLATGGADSIIALFDTKDWICQRTVSCLVGPVKSISFTFDGSYVVGGCEEGSGLEVTHTETGEHVHTFKTAGPCEAVAWAPTRYCLAYSDLGVLRIIGLDADRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0S0</accession>
    <name>G0S0S0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0011020</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691622.1">
        <property type="nucleotide sequence ID" value="XM_006691559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0S0"/>
    <dbReference type="STRING" id="759272.G0S0S0"/>
    <dbReference type="GeneID" id="18255140"/>
    <dbReference type="KEGG" id="cthr:CTHT_0011020"/>
    <dbReference type="eggNOG" id="KOG0126">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045495_2_1_1"/>
    <dbReference type="OMA" id="GSWHVDY"/>
    <dbReference type="OrthoDB" id="2573941at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12411">
        <property type="entry name" value="RRM_ist3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051847">
        <property type="entry name" value="RNA_proc/Spliceosome_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045844">
        <property type="entry name" value="RRM_Ist3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880:SF1">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="33"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="133"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="207"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="237"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="352"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS22630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="367" mass="44842" checksum="2511B68C456B70DD" modified="2011-10-19" version="1">MNQIRAIQALNKREIEQGIPPEASWHADYRDTAFIYFGGLPYELSEGDIITIFSQFGEPVFLKLARDKETGKSKGFGWLKYEDQRSTDLAVDNLSGAEIGGRLIRVDHARYKLRDDEDPAEYDVSWEAMVRRERREKGLPSESEESSEDEEEEERRRRPLLKEERELQMLIENHDDDDPMKQFLIEEKKKEVEEALRREAKKAEKSSRRRRHRSQSRSKSKSRSRSRDRHHRSHRSRRDDHDDGERHREKDKYRDREDRDSDRKRRSRDDTPVEEDKDRKRRRDTPDDRRDRDDRRDRDRSRDRARDRDGDRREDYRRQDDGRDRDRDKRRRHADSPERSERRHRDLEDRTRRPKDRSRSRSPRRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0S195</accession>
    <name>G0S195_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0012800</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691797.1">
        <property type="nucleotide sequence ID" value="XM_006691734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S195"/>
    <dbReference type="STRING" id="759272.G0S195"/>
    <dbReference type="GeneID" id="18255318"/>
    <dbReference type="KEGG" id="cthr:CTHT_0012800"/>
    <dbReference type="eggNOG" id="KOG2454">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_1_0_1"/>
    <dbReference type="OMA" id="ILMRGTF"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07098">
        <property type="entry name" value="ALDH_F15-22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000014">
        <property type="entry name" value="aldehyde dehydrogenase 22A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000024">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="83"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS22805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="608" mass="66205" checksum="07E67A37655C319B" modified="2011-10-19" version="1">MASTVVDTVLQLLDQLPPIIQQFSPKNSPETYLTVLAAIVLAYSNWLLFQSLSNRPIPYKVSPPERPEKPEILEKPSIKVEGSNTIRCYAPATGELLGYVEPATPETIDRAIEEAHEAQKKWANTSFNERRAVLRTLLQHVLDNQEQICRIACLDSGKTMVDAQLGEVLVTVEKLQWTIKHGEKALVPERRPTNLLMTYKRNTVRYEPLGVVSALVSWNYPFHNLIGPVISAIFSGNGILVKVSEQTAWSSQYFTKLIRGALIAHGHDPRLVQTVVCWPEVAGHITSHPRISHITFIGSRPVCHKVAASAAKALIPVVAELGGKDASIILDTVSKSDLPRVVEILMRGSFQASGQNCIGIERIIAAPGIYDKLVSLLEPRVRALRLGQNADVGAMISDNNFARLEGLIAEAVSRGARLLVGGKRYAHPDYPNGHYFSPTLLVDVTPDMAIANEECFAPIMVIMRAPSPSAEDILAVANAPDFGLGSSVFGADSDPRIPKIVRGIKAGMISVNDFAATYAVQLPFGGVAGSGYGRFAGEEGLRGLCNVKAVCEDRMSWLGVRTAIPPPMRYPVVDQERSWRFAKGIVEVGYAMGLWGKLAGVLGIVKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1A9</accession>
    <name>G0S1A9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative L-ascorbic acid binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0012950</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691811.1">
        <property type="nucleotide sequence ID" value="XM_006691748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1A9"/>
    <dbReference type="GeneID" id="18255333"/>
    <dbReference type="KEGG" id="cthr:CTHT_0012950"/>
    <dbReference type="eggNOG" id="ENOG502QR14">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041456_0_1_1"/>
    <dbReference type="OMA" id="QFFGQHY"/>
    <dbReference type="OrthoDB" id="69177at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000021">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF236">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="143"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS22819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="260" mass="29380" checksum="4AF23988698BB9F3" modified="2011-10-19" version="1">MAKDKRSKGAHGSSGSSTTTSSNKGNNTNNQPPISTPPAWPVFKPKLPVVDLQLEPYPGVEDKVVVFRSFWPRSLCKDYVAFLRELPLVTTPGKPKRGEAVRVNDRFQIDDPKFAHRLWTETGLKEALLKEEYLHMWGGQVVGLNPNIRIYRYRPGQFFDAHYDDYNYVTVAPEPGAPPISAKTTWTLLLYLTSQADGCIGGETVFFPRDRRNPKEEIAVSLETGMLLLHKHGNDCMLHEAREVTAGEKWVIRTDLCIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1D7</accession>
    <name>G0S1D7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Non-structural maintenance of chromosomes element 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0013230</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the SMC5-SMC6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NSE4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691839.1">
        <property type="nucleotide sequence ID" value="XM_006691776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1D7"/>
    <dbReference type="STRING" id="759272.G0S1D7"/>
    <dbReference type="GeneID" id="18255361"/>
    <dbReference type="KEGG" id="cthr:CTHT_0013230"/>
    <dbReference type="eggNOG" id="KOG2866">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041037_4_0_1"/>
    <dbReference type="OMA" id="FMGINRT"/>
    <dbReference type="OrthoDB" id="361242at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027786">
        <property type="entry name" value="Nse4/EID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014854">
        <property type="entry name" value="Nse4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029225">
        <property type="entry name" value="Nse4_Nse3-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15412">
        <property type="entry name" value="Nse4-Nse3_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08743">
        <property type="entry name" value="Nse4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nse4/EID protein Nse3/MAGE-binding" evidence="10">
        <location>
            <begin position="103"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Non-structural maintenance of chromosome element 4 C-terminal" evidence="9">
        <location>
            <begin position="313"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="147"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="332"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF15412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS22847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="391" mass="44404" checksum="2BB2D701E4EF6241" modified="2011-10-19" version="1">MESSSRKRTSTGFDEPSHTRRRTREPSPDAMLLDDDNDFEDYDPDQPMQERRAIQASLRQMQRQLRENPDEYMQADPKSLLQFFDESDRIMKNVKQTSEAAIDSRGLVLAADLSARRIQKLTLGLSSGGVDVDEFVSKVITFMTEGGGIEDDDAPELSSTQRRRRRMPANRGSGDEEDVEFNENDGDMLNWAHLGRYAVMPSIRRPALPGFLLGPLSVEKKARKQGKRGQVLRVDRLEETRPQELKAEDLKKSDKNDLPSICKKIYVQLQASQRTAQDKAQEEINNLPEDATSDDERAAMDRYALRSTGGIDLLREGNVKLEFDENGLPSISKESSSGSTRAKTSTRRQAIMSIDMDTWRDIIETFNIREPMIPHREEESTQGPGARSWYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1V4</accession>
    <name>G0S1V4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcriptional activator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0014960</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS23014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692006.1">
        <property type="nucleotide sequence ID" value="XM_006691943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1V4"/>
    <dbReference type="STRING" id="759272.G0S1V4"/>
    <dbReference type="GeneID" id="18255534"/>
    <dbReference type="KEGG" id="cthr:CTHT_0014960"/>
    <dbReference type="eggNOG" id="ENOG502S8VT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035351_0_0_1"/>
    <dbReference type="OMA" id="NCPRYFL"/>
    <dbReference type="OrthoDB" id="21557at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="415" mass="43982" checksum="354ACE8D88546214" modified="2011-10-19" version="1">MASENAPETGKCGVIVAPSDESPKERLAHAVLDDLLYNILHDLLLKVHRDEKIARANTAAIKVEKLAQNSVDGATDTKPDVEVETEAAVYKDGKVTLKGNPLKTTKEILCPRCHLPRLLYPTDGKGARKPDPGVIYCKRHPYIEKPGYDIYGQTWVAPGPGRGKKKQKPDPNDPNSPITADVSAKDRPPNVLSFPSATCSKCKRCILVTRLNNHMGACIGNSGRTASRAAAQKISNGSNVGSQNDNTPPGSQKGTPLPSSRAASPRKRDADDMDNDDGDEEDSSKPKKKVKVINKKVIIKTNKSPAGTPGSISVKSKDNKPKTSSGLSVEQKPDEPATADSVVAKPDPSTVQVAPKKTINPSSGTSKSASPAKKIKLGPAKPSLPPPTAAAAAAKKIKKEKDESESSGTLSSPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0S270</accession>
    <name>G0S270_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Letm1 RBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0016190</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692122.1">
        <property type="nucleotide sequence ID" value="XM_006692059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S270"/>
    <dbReference type="STRING" id="759272.G0S270"/>
    <dbReference type="GeneID" id="18255657"/>
    <dbReference type="KEGG" id="cthr:CTHT_0016190"/>
    <dbReference type="eggNOG" id="ENOG502S645">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048915_0_0_1"/>
    <dbReference type="OMA" id="HYVPKTF"/>
    <dbReference type="OrthoDB" id="73691at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033122">
        <property type="entry name" value="LETM1-like_RBD"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51758">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Letm1 RBD" evidence="4">
        <location>
            <begin position="116"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS22103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="302" mass="33737" checksum="57FCC9B6EC2EA51E" modified="2011-10-19" version="1">MPALRTDACSPKLHETQSYTLSPEAANPPPTTRPAPLDIPPPPHPKPDPFTIENLRYRFAIGRAYLQFYKAGLKNIWLNTRLLYSSSATSDPELSKLRPYPSTRADLLLRQRWRHDVRRLPLFALLLLIFEEFTPLIVLLLPKSVPLTCRIPKQVQSLLRKAESSRREARALPSVQSYLSSHNSTSKSLPVDALATILSVRSSWTLPLRFLLASKVQRRLKFLSLDDALLIQAGGQGALVGEEVVLACVDRGIEVVGRDVDSELRVALGRWLARVAEAERKGGQESGERERVRMLLEGVGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2L8</accession>
    <name>G0S2L8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0017700</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692270.1">
        <property type="nucleotide sequence ID" value="XM_006692207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2L8"/>
    <dbReference type="STRING" id="759272.G0S2L8"/>
    <dbReference type="GeneID" id="18255808"/>
    <dbReference type="KEGG" id="cthr:CTHT_0017700"/>
    <dbReference type="eggNOG" id="ENOG502S01H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069193_0_0_1"/>
    <dbReference type="OMA" id="ILNCHYG"/>
    <dbReference type="OrthoDB" id="5392202at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052999">
        <property type="entry name" value="PTS1_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180">
        <property type="entry name" value="CONSERVED MITOCHONDRIAL PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180:SF2">
        <property type="entry name" value="PEROXISOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="30261" checksum="CBBEC58C1EB24F9C" modified="2011-10-19" version="1">MPGAESATKKPTHNGPLVRQKKDKRTKANDKDMSKLSPSLKALINAPFARPGQAPAPRQIRDIYARIAREARERRYGERPWIALSAAATFTLNSPASLLILHDVATTNPPPDTTPLSPLAAAELIREIGLKCISFNGIPRTINCLGAFKAGLSPSITSQLSTTPTRTVTPSNAVAVAARGRNLWHSVYTPFDAKLETKLADSHPDLPVHILSSHYGPLLSDPEPGRALGRVGRALTSVVAIACLRAQTGVGPQVLSHVFGLRKAVEQGVHGLGEEFGGGGDGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2W8</accession>
    <name>G0S2W8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0018760</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692370.1">
        <property type="nucleotide sequence ID" value="XM_006692307.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S2W8"/>
    <dbReference type="GeneID" id="18255914"/>
    <dbReference type="KEGG" id="cthr:CTHT_0018760"/>
    <dbReference type="eggNOG" id="ENOG502SE9H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007974_0_1_1"/>
    <dbReference type="OMA" id="LWNVYYH"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027974">
        <property type="entry name" value="DUF4470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024119">
        <property type="entry name" value="TF_DEAF-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237">
        <property type="entry name" value="DEFORMED EPIDERMAL AUTOREGULATORY FACTOR 1 HOMOLOG SUPPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237:SF15">
        <property type="entry name" value="LD37257P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14737">
        <property type="entry name" value="DUF4470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="1233"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1174"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1279"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1174"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1204"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1286"/>
            <end position="1298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS22351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1298" mass="146682" checksum="90E4C887FC3449B8" modified="2011-10-19" version="1">MHTPTSLEAFEHKEAIEMHSFNPAISLTRGLPQGIDADILLLGVKDVRDILYTVYANNGFPERKIDITVSRDITLYTILLDNDETVSFDRIWDLYYNLYIASTDLDYYESHVTKLITLSSSPSSWQAGPYASTIRFCDEASLKLLNKVWRDAVQISVNRKSSQEWFQKGLQEANAQPNPWKGARRVGWRSLAPLYSRTAGKMLLELTEQHWGTGRSFPRSDDDTSELFPNPSFGVAIRRPSLLTYPTDPLLSFHLAAAIARLHDGSPLKLDDRDGEDNHQKRMYEVARLQFKEWIEAFRLARDKVTLRFEVADCFAFCYTLRHADETGERCAHWYRARVGVEPLVLGEEYGSDGTAPKKFDVVDTATRSDQAGILNLLVAAKPLLKDAPSSTLYTDTAHAIQDMGKYEELLLGRTTTLSTLLGLYPITGLTASKPLNAVDEILTAWQDPAPTPQEGQPEAVGTEEKKESATHKSYGFRLAWKLADRMVWHGQDLPGSLEVKEDDLLVLANKLYFDLFEYPHKVNQLPEEAEQVAHLKKGKRMQYHAGSFAAILTALCKHTQVDPYSLVSKLETRINGYWATVAGLYENNVQQLLAEFLLTMPAEVRQTPINRPSWMGLYSWKDVPPVVAVTIAIPWEHWSAVMNRTRIGDLAVMNGYVAFPHKDKVIEKRVYCDIQIAFGEPVTQGKPDEDDFAIAIDEQNDQEAKCPMIVTFNALTEDFRSDGYVGFRCKRTRHNTDGSEEETQNRFYEYRVPIISPNVHVSKFRPGQTGHKINETHLQGWAARATALETPSPDASFPVTFDDKSENITMLTGHLSITSDKGKELLAAKVPIVLQQFDPFTINIAFGKAKIKKDLILPLTFPAPVTKEGSKTRIARTSGYIEIDAPMVKTMEPVLDDYILPTTLYKQPSTDSITPVTLNTPHINLDTLPILALDDKSRIRFLTTLTSLTFSSRDRQLREEIRRAQDAKKQLDTPPPARLNIKESLFTMFMLASGLQGGQTGLFTLTHPKRGGNHMLFLVSAIRLDPAHGSVVLDAAVLPVTTDLISEHRIDEFLVTLRAVESCTLTVDDAELEAWKKMLPALAERCRTWEHDREKCEYIKTGNVPISLKDGDPVLCSCGMGKLPEGFSPLPLWDDGPSKYATRIAISPVYATALVEKVVDPLLTVEGLQREERKKAKQKREWEEEEERKEKEAKGEKDKDGDVEMAEAGEEDDFDYPSTITEDDEEYKRIRCWNCGKMEGEDGVTLKRCLRCLEARYCSSQCQKKDWKKHKMECEEADVYHQEEQQQQAQPQPQQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0S347</accession>
    <name>G0S347_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0019630</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692449.1">
        <property type="nucleotide sequence ID" value="XM_006692386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S347"/>
    <dbReference type="GeneID" id="18256001"/>
    <dbReference type="KEGG" id="cthr:CTHT_0019630"/>
    <dbReference type="eggNOG" id="ENOG502RNEZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1320764_0_0_1"/>
    <dbReference type="OrthoDB" id="5337493at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033432">
        <property type="entry name" value="GH94_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052047">
        <property type="entry name" value="GH94_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005194">
        <property type="entry name" value="Glyco_hydro_65_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37469:SF2">
        <property type="entry name" value="CELLOBIONIC ACID PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37469">
        <property type="entry name" value="CELLOBIONIC ACID PHOSPHORYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03633">
        <property type="entry name" value="Glyco_hydro_65C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17167">
        <property type="entry name" value="Glyco_hydro_94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl hydrolase 94 catalytic" evidence="4">
        <location>
            <begin position="4"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 65 C-terminal" evidence="3">
        <location>
            <begin position="134"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS22430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="208" mass="23628" checksum="CB20EAA00846DA75" modified="2011-10-19" version="1">MIPQIDQQLNTPYGVLMFAPPFTKMREDIGRVTQKAIGSAENGAVYNHAGAFYIWSLYKLGNQPDRAYTHLRQMIPGPSEADYFQRGQLPVYIPNYYRGGWREFPRTAGRSSQLFNTGTVSWVYRCVIEGLCGLRGDDDGLWVRPQLPSTWDRMRVTRVFRGATFVVEVRRGDVDTVVVKVGDLILHEPKVTDFRAGETVKVEVVVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0S359</accession>
    <name>G0S359_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Small ribosomal subunit protein mS37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0019770</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the mitochondrion-specific ribosomal protein mS37 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692461.1">
        <property type="nucleotide sequence ID" value="XM_006692398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S359"/>
    <dbReference type="STRING" id="759272.G0S359"/>
    <dbReference type="GeneID" id="18256015"/>
    <dbReference type="KEGG" id="cthr:CTHT_0019770"/>
    <dbReference type="eggNOG" id="ENOG502SBQ7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162186_0_0_1"/>
    <dbReference type="OMA" id="INYHAAR"/>
    <dbReference type="OrthoDB" id="2210at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017264">
        <property type="entry name" value="Ribosomal_mS37_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28066">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28066:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037706">
        <property type="entry name" value="MRP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="92" mass="10139" checksum="4077D8739A06A228" modified="2011-10-19" version="1">MTNRNPMRLPPLPQLRVRNPNKPEPNPCLGVMTSVLACWASAGFNGRGCQTVEAALRACMDGPPPPRKMGNTINYHLARFARRVTQPGTKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3C8</accession>
    <name>G0S3C8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0020550</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="11"/>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692530.1">
        <property type="nucleotide sequence ID" value="XM_006692467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3C8"/>
    <dbReference type="STRING" id="759272.G0S3C8"/>
    <dbReference type="MEROPS" id="M01.A25"/>
    <dbReference type="GeneID" id="18256093"/>
    <dbReference type="KEGG" id="cthr:CTHT_0020550"/>
    <dbReference type="eggNOG" id="KOG1046">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003705_0_1_1"/>
    <dbReference type="OMA" id="HDMAGFY"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000001">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000004">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF171">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11 15" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="14">
        <location>
            <begin position="12"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="12">
        <location>
            <begin position="246"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="13">
        <location>
            <begin position="537"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS22511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="884" mass="99740" checksum="1F3881E21E7C6A97" modified="2011-10-19" version="1">MTDRDILPDYFKPVHYDLVIRDLDFSNWTYKGTVRIDGQLRKSTTEIVINTLELKLLSAKVTTGEQSWDATGFAEDTKSQRSTISFAEALPEAPEASLSIEFTGILNHDMAGFYRSQYKPAAPAAASVPRDDEFHYMFSTQFEACDARRAFPCFDEPNLKATFDFAIEIPDDLVALSNMPVKEETPVEGSKKLVSFERTPIMSTYLLAWAVGDFEYVEAFTEREYNGKKLPVRVYTTRGLKEQGRWALEHAPKIIDYFSEQFEIDYPLPKSDILAVHEFTHGAMENWGLVTYRMTAILFDEKLSEARFRNRIAYVVAHELAHQWFGNLVTMDWWDELWLNEGFATWAGWLATDYLHPDWEVWPQFINEGMDQAFLLDSVRSSHPIQVEVRDALDVNQIFDKISYLKGCSMIRMLASNLGIETFLKGIAIYLRRHAYGNAKTKALWDALSEASGVDVNALMEPWIEKVGFPVVTVTEGNQQISVKQSRFLSTGDVKPEDDTTTWWVPLALKGKIGSEGVEPLALTTKEATIEGVSNEFYQLNAGATGFYRVNYPEARLKVLGTQLEHLTTEDKIFITGSAADLAFSGYATTGALLGFIQGLKNETHYRVLSQALDALGTLKSIFGDDEQTKKGLEKFTLELIDKALKQVGWEGPKGEDFNTSLLRKRLLLTAVANGHEEVAAKAYERWTAYQANPTENPIPADLRSPVYRAAIRKDPAAAVAGLKKEWFTTPAIDGKEICLQALGHVHDETVIKNVLLPFLFNISPPVHPSESVPPADMHILAGNLAGNRNARHHLWAYLRDNWDQFNAKLGGNPILVDRMISVSLPKFTDIETLQDIEKFFEGVSTKGFDRTLEQVKDKIRGRVAYKLRDAEGVRAWLVENRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3W9</accession>
    <name>G0S3W9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Regulator of phospholipase D SRF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0039160</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS22031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694327.1">
        <property type="nucleotide sequence ID" value="XM_006694264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3W9"/>
    <dbReference type="GeneID" id="18257954"/>
    <dbReference type="KEGG" id="cthr:CTHT_0039160"/>
    <dbReference type="eggNOG" id="ENOG502QPXG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027163_2_0_1"/>
    <dbReference type="OMA" id="MPIADHQ"/>
    <dbReference type="OrthoDB" id="2589563at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037737">
        <property type="entry name" value="Srf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36819">
        <property type="entry name" value="REGULATOR OF PHOSPHOLIPASE D SRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36819:SF1">
        <property type="entry name" value="REGULATOR OF PHOSPHOLIPASE D SRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="43675" checksum="92D9BB797DF8EDAB" modified="2011-10-19" version="1">MAAHPPPTSSSHRSDPTSSRSRGSTTGSASGSSLRPAPRTLPPWIDSYQSRFGAPSEDQLRSLSAPPPRTLAPQPTQTPNPHSGIGDPLQRRVSRDGFVYENQPSLTPRDTRRAKARLRKLFFKRRDGSERGRKWDHLRSAEPVIVPRYTRMTGNDSPWRGYLQSSRYGRLPNEESEIVEPEWLNQLQPRFNEPVETPHPTKENGNGNGGDGKGQGTRTRRSYKRLWRMMLEHPLIPLAFRLTVLLTSIVALALSAKIYQLEHGRPRPGTSAHSAELTQSVVAIVVDTVAMPYIGYMTWDEYTGKPLGLRKATQKISLVLMDLFFIIFKSASTALAFEALVFHNSADRVTRAYSQALAAFQLVGLISWSFTFTVNVFRLVQKLGGGEDDRG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-03-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0S488</accession>
    <name>NMD3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName>60S ribosomal export protein NMD3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">NMD3</name>
        <name type="ORF">CTHT_0031110</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
        <text evidence="1">Shuttles between the nucleus and the cytoplasm in a XPO1/CRM1-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NMD3 family.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="EGS21262" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21262.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693558.1">
        <property type="nucleotide sequence ID" value="XM_006693495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S488"/>
    <dbReference type="SMR" id="G0S488"/>
    <dbReference type="STRING" id="759272.G0S488"/>
    <dbReference type="GeneID" id="18257149"/>
    <dbReference type="KEGG" id="cthr:CTHT_0031110"/>
    <dbReference type="eggNOG" id="KOG2613">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018005_0_0_1"/>
    <dbReference type="OrthoDB" id="203821at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048899">
        <property type="entry name" value="NMD_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048898">
        <property type="entry name" value="OB_NMD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746:SF2">
        <property type="entry name" value="60S RIBOSOMAL EXPORT PROTEIN NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21193">
        <property type="entry name" value="NMD_SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21192">
        <property type="entry name" value="OB_NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000435818" description="60S ribosomal export protein NMD3">
        <location>
            <begin position="1"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="473"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Nuclear localization signal" evidence="1">
        <location>
            <begin position="410"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Nuclear export signal" evidence="1">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="504"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P38861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="518" mass="59027" checksum="554D232DDB004CE6" modified="2016-03-16" version="2">MDLDSPMGMAPMMGTARTGATILCCNCGVPIDGTSSAGALCYDCIKSTVDISQGIQREGTLHFCRDCERWLMPPSTWVAAAPESRELLSLCLKRLRNLGRVRIIDARFVWTEPHSRRIKVKITIQDQVSDGVLMQQSFEVVYVVAYQQCRECAKSYTANVWRAVVQVRQKVTHKRTFLLLEQLILKHQAHKDTINIKEEKDGVDFFFAQRNQAEAFVHFLKSVVPITLKDSRHLISQDTHTGDKQYKFTYSAEIIPICRDDLVALPLKLAKQIGNIPPLCLCYRIGTAVYLLDPNTLHTAELSSDVYWRQPFRPLADATSMVEFIVMDIEATGIRKGKWVLAEVTVARASDLGVNDNVYFTRTHLGHLLHPGDSVMGYMLTGTNFNSDTFDAIENSRQYGSTIPDVVLVKKHYPNRRRNRRRNWKLKRLPKDEGELLPKATDQARMDDEYEAFLRDVEEDEELRATLALYKNTRKTKKPQQDADAMSIAETEDDDDGPKISMDELLDDFEDLDIQDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4A8</accession>
    <name>G0S4A8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBL3-like ubiquitin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0039510</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS22066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694362.1">
        <property type="nucleotide sequence ID" value="XM_006694299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4A8"/>
    <dbReference type="STRING" id="759272.G0S4A8"/>
    <dbReference type="GeneID" id="18257989"/>
    <dbReference type="KEGG" id="cthr:CTHT_0039510"/>
    <dbReference type="eggNOG" id="ENOG502S95Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055856_1_0_1"/>
    <dbReference type="OMA" id="HESTPQQ"/>
    <dbReference type="OrthoDB" id="1043111at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040015">
        <property type="entry name" value="UBL3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039540">
        <property type="entry name" value="UBL3-like_ubiquitin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13169:SF0">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13169">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 3 HCG-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13881">
        <property type="entry name" value="Rad60-SLD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBL3-like ubiquitin" evidence="2">
        <location>
            <begin position="152"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="247" mass="27014" checksum="A1345692A5FB7B65" modified="2011-10-19" version="1">MGELSLENPGGQPEKQSQNTAPTESTEPQFSTTKTSAEFKSQSTKSATVAESSTAAAAAISQEDPKPSDNIKLDISAPQPTDNDSLSIEPSDPPPAGGISSSNTKPDPPVCNITLLLPTGARHPYRIDEKYLAKRNVSVPETTETGAKDPFSISVYKLKELILREWREEWEAKPASPSSIRLIHFGKLLDDKEPLKKYQFSTDSPNVVHMSVRPAEMMEEDEGSKTKRSSSREGRPRERESGCCVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5H2</accession>
    <name>G0S5H2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0032950</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693733.1">
        <property type="nucleotide sequence ID" value="XM_006693670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5H2"/>
    <dbReference type="STRING" id="759272.G0S5H2"/>
    <dbReference type="GeneID" id="18257333"/>
    <dbReference type="KEGG" id="cthr:CTHT_0032950"/>
    <dbReference type="eggNOG" id="KOG3293">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008514_1_1_1"/>
    <dbReference type="OMA" id="CLRIHAN"/>
    <dbReference type="OrthoDB" id="747253at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097525">
        <property type="term" value="C:spliceosomal snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01723">
        <property type="entry name" value="LSm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000024">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034101">
        <property type="entry name" value="Lsm4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057027">
        <property type="entry name" value="TPR_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23276">
        <property type="entry name" value="TPR_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="2"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="10">
        <location>
            <begin position="512"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS21437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="769" mass="87566" checksum="19CFEED6E3E08765" modified="2011-10-19" version="1">MLPLGLLTAAQGHPMLVELKNGETLNGHLVQCDTWMNLTLREVVQTSPEGDKFMRLPEVYVKGNNIKYLRVPDEIIDIVKEQQQQQHRGAVVGEEEVALREVDGVARGVHECDSCWDSLNGTLATGMGVVQRHRHLQRQQQQLLLLRDYETTTWRNSFWGTSLGSRFGEKARQEDVGAQQFEHAVGDRCMTRRKHDWEVWGEGSRGNAFSPQPLPQQASVSSSQGPARVQMQHENAPVTADDLIKSEASFPQRTFQASTEVIYEALRGLRERRDGAIKIRRFVEHLVKERGEQPNEALYEALVVANWHTTTGSAGELRAIMKEMKKLGIKFSESFYHSALRLLAIHPDYITRTIILDKMNEEGILLNDDGKCSVALGYLRDGQYEMALDYLDQICHEGVDVPGWMFDIFFFVLTRHGFLDEALHLLQYLVDRAEGFLNAVPLNSWYYFLDECSKAFYYEGTKFVWENLVRPGILHPSDGVMINVLNTASRYNDAELATKVIEQLSARKIKLTANHYEALLDCYANIGDLQNAFQVLSIMADAGIMPDQSSTRSLYLFLKSHPERADEVVKILNELSKDHRIPVAAMNVVLEALLKAGDMVKAMHVYRDLRYLCKGGPNQQTFQMLLEQCKSSEVAGFLTSEMHQFSVRSSPEILDHVIRCFAFDGLLDAVLSYLSEWNRSPMRRGWISTPTLTAVLERCYRARDVRVWRVVDEAQRRNVRIDPQIMEVLEAEIPRADAYRELPAHGWATSDEAYQSKEVSSDSKDYASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5P7</accession>
    <name>G0S5P7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal RNA-processing protein 15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0025020</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e56910" last="e56910">
            <title>Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation during pre-60S biogenesis.</title>
            <authorList>
                <person name="Lau B."/>
                <person name="Huang Z."/>
                <person name="Kellner N."/>
                <person name="Niu S."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
                <person name="Cheng J."/>
            </authorList>
            <dbReference type="PubMed" id="37129998"/>
            <dbReference type="DOI" id="10.15252/embr.202356910"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.10 ANGSTROMS)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP15 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692962.1">
        <property type="nucleotide sequence ID" value="XM_006692899.1"/>
    </dbReference>
    <dbReference type="PDB" id="8I9R">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="Ch=1-354"/>
    </dbReference>
    <dbReference type="PDB" id="8I9T">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.60 A"/>
        <property type="chains" value="Ch=1-354"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5P7"/>
    <dbReference type="EMDB" id="EMD-35281"/>
    <dbReference type="EMDB" id="EMD-35283"/>
    <dbReference type="SMR" id="G0S5P7"/>
    <dbReference type="STRING" id="759272.G0S5P7"/>
    <dbReference type="GeneID" id="18256540"/>
    <dbReference type="KEGG" id="cthr:CTHT_0025020"/>
    <dbReference type="eggNOG" id="KOG2974">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058264_1_0_1"/>
    <dbReference type="OMA" id="KTAPVDH"/>
    <dbReference type="OrthoDB" id="20949at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012459">
        <property type="entry name" value="Rrp15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13245">
        <property type="entry name" value="RRP15-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13245:SF14">
        <property type="entry name" value="RRP15-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07890">
        <property type="entry name" value="Rrp15p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5 6" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS20666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="8I9R"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="8I9T"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="38245" checksum="971FB8DCD25634C2" modified="2011-10-19" version="1">MAGSVKKRSLSDGLKGRVAPPPKKQKKMEYRSSSEKSDSSSDDGGVPLPPNLLDSDDEDFDNIEVDDGATTASSSDDDSDSDSFSESEPKPKKSAKSSKQAPKPPKKDDKNFVAKDAPSSEESDFSEYGSDHDDDSDEEGENDEYSDLSDADTHASSVAGSATSSKSGQHKKSKRNDPDAFAESMKKMLSSKLPASKRADPIVARSAAAAEHARQAADAALEAKARKRLREQKRLALEKGRVRDVLVASTTRTFNVETGKVEEVVDEEGVTTEQIIERERKLRKIAQRGVVKLFNAVRAAQLKALEAEKAARREGVIGSKQKEEKVTEMSRKGFLDLIASGGGGLKKGALEEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>G0S664</accession>
    <name>G0S664_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ubiquitin-conjugating enzyme E2 2</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CTHT_0034330</name>
    </gene>
    <organism evidence="24">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693868.1">
        <property type="nucleotide sequence ID" value="XM_006693805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S664"/>
    <dbReference type="STRING" id="759272.G0S664"/>
    <dbReference type="GeneID" id="18257471"/>
    <dbReference type="KEGG" id="cthr:CTHT_0034330"/>
    <dbReference type="eggNOG" id="KOG0419">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_10_2_1"/>
    <dbReference type="OMA" id="DHKSQYI"/>
    <dbReference type="OrthoDB" id="9984419at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="UBQ-conjugating_AS"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="UQ_con"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
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    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0749">Sporulation</keyword>
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    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 21" id="KW-0833">Ubl conjugation pathway</keyword>
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        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="20">
        <location>
            <position position="88"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EGS21572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="151" mass="17257" checksum="5A45BF6337EE2AC5" modified="2011-10-19" version="1">MSTAARRRLMRDFKRMQTDPPAGVSASPLPDNVMTWNAVIIGPADTPFEDGTFRLVMHFEEQYPNKPPSVKFLSQMFHPNVYATGELCLDILQNRWSPTYDVAAVLTSIQSLLNDPNTSSPANVEASNLYKDNRKEYFKRVRETVEKSWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6F8</accession>
    <name>G0S6F8_CHATD</name>
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        <recommendedName>
            <fullName evidence="1">Clr5 domain-containing protein</fullName>
        </recommendedName>
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    <gene>
        <name evidence="2" type="ORF">CTHT_0034770</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EGS21613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
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        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788:SF3">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="1">
        <location>
            <begin position="29"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="185" mass="22042" checksum="11E407F4CD27F853" modified="2011-10-19" version="1">MSNYYMYAQGQHYQQPQQSQATMIRPTKPEDWEPYREIIAEMYNTLNMRLKDVMTQMQIAYNFKATEKQYKTQLKKWNLDTKYIKASEYLYMIKTLRERKAIDPNKETRFILRGKVVDPKDIARFEKRAIKKGLLKEGEPIHVDDEPIEEITCCTPPPEGMDSYPVWQTGDYDGYDPSSEYPYSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6L5</accession>
    <name>G0S6L5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Mitochondrial import receptor subunit tom22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0026640</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="15 16 17" key="2">
        <citation type="journal article" date="2025" name="Proc. Natl. Acad. Sci. U.S.A." volume="122" first="e2507279122" last="e2507279122">
            <title>Structures of &amp;lt;i&amp;gt;Chaetomium thermophilum&amp;lt;/i&amp;gt; TOM complexes with bound preproteins.</title>
            <authorList>
                <person name="Agip A.A."/>
                <person name="Ornelas P."/>
                <person name="Yang T.J."/>
                <person name="Uboldi E."/>
                <person name="Hader S."/>
                <person name="McDowell M.A."/>
                <person name="Kuhlbrandt W."/>
            </authorList>
            <dbReference type="PubMed" id="40674418"/>
            <dbReference type="DOI" id="10.1073/pnas.2507279122"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom22 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693122.1">
        <property type="nucleotide sequence ID" value="XM_006693059.1"/>
    </dbReference>
    <dbReference type="PDB" id="9I6B">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="C/D=1-158"/>
    </dbReference>
    <dbReference type="PDB" id="9I7P">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="C/D=1-158"/>
    </dbReference>
    <dbReference type="PDB" id="9I7S">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="C/D=1-158"/>
    </dbReference>
    <dbReference type="PDB" id="9I7T">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.80 A"/>
        <property type="chains" value="C/D=1-158"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6L5"/>
    <dbReference type="EMDB" id="EMD-52652"/>
    <dbReference type="EMDB" id="EMD-52658"/>
    <dbReference type="EMDB" id="EMD-52660"/>
    <dbReference type="EMDB" id="EMD-52661"/>
    <dbReference type="STRING" id="759272.G0S6L5"/>
    <dbReference type="GeneID" id="18256702"/>
    <dbReference type="KEGG" id="cthr:CTHT_0026640"/>
    <dbReference type="eggNOG" id="KOG4111">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094333_1_0_1"/>
    <dbReference type="OMA" id="LVWIVTT"/>
    <dbReference type="OrthoDB" id="10016939at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22884">
        <property type="entry name" value="TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005683">
        <property type="entry name" value="Tom22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04281">
        <property type="entry name" value="Tom22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="15 16 17" id="KW-0002">3D-structure</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS20826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="9I6B"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="9I7P"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PDB" id="9I7S"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="17250" checksum="02EFFA1DB5A87B8F" modified="2011-10-19" version="1">MVQLVEVEDEHFTQPQPGPEEDDDEYTDTDSEISTESNFDPSEETLADRLHALRDMVPPAYRGWIYHKYEQTTSAVRKALSFAGRAAWTVSVTALLVGVPFSLAYGEDQQYAAMEQEQRMRELGGEVLTAGAPGSQGGGLTAEQVNAALGRSEAKPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6N1</accession>
    <name>G0S6N1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0034970</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. COT1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693929.1">
        <property type="nucleotide sequence ID" value="XM_006693866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6N1"/>
    <dbReference type="STRING" id="759272.G0S6N1"/>
    <dbReference type="GeneID" id="18257535"/>
    <dbReference type="KEGG" id="cthr:CTHT_0034970"/>
    <dbReference type="eggNOG" id="KOG0605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_67_5_1"/>
    <dbReference type="OMA" id="HDNAYYQ"/>
    <dbReference type="OrthoDB" id="3638488at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000086">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000229">
        <property type="entry name" value="Serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000192">
        <property type="entry name" value="Serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="250"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="555"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="107"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS21633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="631" mass="71574" checksum="4C73347C0AA5CF06" modified="2011-10-19" version="1">MDNQGNRLYLNFNNANNDRLAANDRAYPTTPSTFPQPIYQGQPGTPASAVPQSHAYQQQQPYGQGGYFQYGQYAQASPYSSAGQGYGQAGQNAAGVAIDPNTGLAQQFSHQNLGDGSRSPHAARGASPGQRPRTAGGQGQQPGYSSYLNAPPMPTHTAQSGFFVPAPERNPEKYGQTAHHNQKKCSQLASDFFKDSVKRARERNQRQSEMEQKLAETTDPRRRESIWTTSGRKEGSYLRFLRTKDKPENYKTIKIIGKGAFGEVKLVQKKSDGKVYAMKSLIKTEMFKKDQLAHVRAERDILAESDSPWVVKLYTTFQDANFLYMLMEFLPGGDLMTMLIKYEIFSEDITRFYIAEIILAIEAVHKLGFIHRDIKPDNILLDRGGHVKLTDFGLSTGFHKLHDNSYYQQLLQGKPSKPKDNRNSIAIDQINLTVSNRSQINDWRRSRRMMAYSTVGTPDYIAPEIFTGNGYSFDCDWWSLGTIMFECLVGWPPFCAEDSHDTYRKIVNWRQTLYFPEDIQLGAEAEHLIRSLICNSENRLGRGGAHEIKAHPFFRGVEFENLRRIRAPFEPRLTSAIDTTYFPTDEIDQTDNATLLKAQMARNGNQQQEESPEMSLPFIGYTFKRFDNNFR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-06-24" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6T0</accession>
    <accession>G0ZGV8</accession>
    <name>POM33_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleoporin POM33</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Nuclear pore protein POM33</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Pore membrane protein of 33 kDa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">POM33</name>
        <name type="ORF">CTHT_0035480</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Contributes to proper distribution and/or efficient assembly of nuclear pores.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 5">The nuclear pore complex (NPC) constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. The 55-60 MDa NPC is composed of at least 28 different subunits: AMO1, ELYS, GLE1, GLE2, MLP1, NDC1, NIC96, NSP1, NUP133, NUP145, NUP152, NUP159, NUP170, NUP188, NUP192, NUP37, NUP49, NUP53, NUP56, NUP57, NUP82, NUP84, NUP85, POM152, POM33, POM34, SEC13 and SEH1. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PER33/POM33 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JF276303">
        <property type="protein sequence ID" value="AEL00696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693978.1">
        <property type="nucleotide sequence ID" value="XM_006693915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6T0"/>
    <dbReference type="STRING" id="759272.G0S6T0"/>
    <dbReference type="TCDB" id="1.I.1.1.2">
        <property type="family name" value="the nuclear pore complex (npc) family"/>
    </dbReference>
    <dbReference type="GeneID" id="18257586"/>
    <dbReference type="KEGG" id="cthr:CTHT_0035480"/>
    <dbReference type="eggNOG" id="KOG4002">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065417_2_0_1"/>
    <dbReference type="OMA" id="NVQYLIM"/>
    <dbReference type="OrthoDB" id="5581259at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071786">
        <property type="term" value="P:endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051645">
        <property type="entry name" value="PER33/POM33_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005344">
        <property type="entry name" value="TMEM33/Pom33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03661">
        <property type="entry name" value="TMEM33_Pom33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0509">mRNA transport</keyword>
    <keyword id="KW-0906">Nuclear pore complex</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000433196" description="Nucleoporin POM33">
        <location>
            <begin position="1"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="topological domain" description="Perinuclear space" evidence="1">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="75"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="topological domain" description="Perinuclear space" evidence="1">
        <location>
            <begin position="125"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="205"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q12164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="21784248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000305" key="5">
        <source>
            <dbReference type="PubMed" id="21784248"/>
        </source>
    </evidence>
    <sequence length="287" mass="32671" checksum="9C546F6B9BA6BD8D" modified="2011-10-19" version="1">MAPPPPSADVPLAERLQRLASTLQFAWFSGHALLLLCVFRYAFSWIRFNYYSGMARFCYRFAFIAAAATYGIVVYKTWRARQKTGVKTSGIKDYLRDENIQYLVLALVWLFMPQYPLALLPYGIYSVFHVATYVRANLIPTLVPPQRINAPAGASPNAKPQYTQHPASEAIGVFVKKYYDSSMSMVARLEIMLWLRLILSVILFQRRSWILFAIYTTFLRTRFSQSIHVQNAFALLEARIDNLIGAQGTPPQARQVWDNVKTAARQFYAVTDLNKYESGVAAPKKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6T4</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">CTHT_0026800</name>
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        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6T4"/>
    <dbReference type="GeneID" id="18256718"/>
    <dbReference type="KEGG" id="cthr:CTHT_0026800"/>
    <dbReference type="HOGENOM" id="CLU_2277178_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="102" mass="10329" checksum="A6DAF616C2762EDF" modified="2011-10-19" version="1">MGSRKRAKQNPTAESSTPHLSPAMSSLASLSAKAASKSSKLQTPATEEPPATPTTATPSVPGTPRSSKAVASNGDATPSAKQACNIQPPSFPSSTKPLQQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0S726</accession>
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        <recommendedName>
            <fullName evidence="5">HIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="6" type="ORF">CTHT_0035910</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
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                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S726"/>
    <dbReference type="STRING" id="759272.G0S726"/>
    <dbReference type="GeneID" id="18257629"/>
    <dbReference type="KEGG" id="cthr:CTHT_0035910"/>
    <dbReference type="eggNOG" id="KOG3275">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056776_0_0_1"/>
    <dbReference type="OMA" id="EIGQWLP"/>
    <dbReference type="OrthoDB" id="1915375at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648:SF2">
        <property type="entry name" value="HIT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="HIT FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="47"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2 3">
        <location>
            <begin position="144"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="1">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS21724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="208" mass="22961" checksum="28B45E7DD0140C87" modified="2011-10-19" version="1">MASEHETPTPSSSFDPSLPKRQSCSDCPFCSISSIYAPYDPQNPPDARSRIIDPNLPSPGPSTFIVLSTPQVMAFLDIMPLSVGHILVCPRNHRPKLTDASQVEAAELGRYLRVLSAAVVRATGIKDWNVVQNNGAAAAQVVPHLHFHIIPRPELRDKRSERFTATMFGRGQRDDLDEGEAVVLAEKIRQEVAKVVKEDQKQQNSSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0S760</accession>
    <name>G0S760_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0027540</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693211.1">
        <property type="nucleotide sequence ID" value="XM_006693148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S760"/>
    <dbReference type="STRING" id="759272.G0S760"/>
    <dbReference type="GeneID" id="18256792"/>
    <dbReference type="KEGG" id="cthr:CTHT_0027540"/>
    <dbReference type="eggNOG" id="ENOG502SZUP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_973806_0_0_1"/>
    <dbReference type="OMA" id="LQWMAFG"/>
    <dbReference type="OrthoDB" id="3524679at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033481">
        <property type="entry name" value="Dni1/Fig1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28092">
        <property type="entry name" value="FACTOR-INDUCED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28092:SF1">
        <property type="entry name" value="FACTOR-INDUCED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12351">
        <property type="entry name" value="Fig1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="278" mass="30180" checksum="A0DDEB9929810B4F" modified="2011-10-19" version="1">MAVQPASIARGAHFFLIIPTVILFALCLTGCISTSPGLPNIYIVSLRSNAPITISNNITINLPTQIRIGYYGICAIDNDGTRCHSVPVEAIHHVNDITDKLFKNKHEPLSNSSSPVVNPNDRTLVKTAVTLQSQVFFSALPFAGVSFLLGVLLLLVLQRLTSSSSATFFRRSTYTFLFGSVALTLCAAVATAQGSAALEHFGTIFEMDEEDGIIVKRGLALQIMQWFILGLQMLFGILVPFVISSSQRDNAVAKAELERGDIGSIHSTFRGPRVRELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7Q0</accession>
    <name>G0S7Q0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">37S ribosomal protein S12-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0037120</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694137.1">
        <property type="nucleotide sequence ID" value="XM_006694074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7Q0"/>
    <dbReference type="STRING" id="759272.G0S7Q0"/>
    <dbReference type="GeneID" id="18257750"/>
    <dbReference type="KEGG" id="cthr:CTHT_0037120"/>
    <dbReference type="eggNOG" id="KOG1750">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104295_0_0_1"/>
    <dbReference type="OMA" id="VCIRVYT"/>
    <dbReference type="OrthoDB" id="361013at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000099">
        <property type="entry name" value="Ribosomal protein S12, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_uS12_bac"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS21841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="166" mass="17817" checksum="589B9277AA2F801D" modified="2011-10-19" version="1">MVTTLFRNLVLRPAIRPAMAPAAPIVRSFSTTPVQSATLNQVLRGCRKPQPKRHPVSPALSAIKAPMLKGVCVKVGITKPKKPNSGERKTARVRLSTGKVVTAYIPGEGHNIQQHSVVLVRGGRSQDCPGVRYHLVRGALDLAGVANRMTSRSKYGAKKPKKATVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7X8</accession>
    <name>G0S7X8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 19">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="7 19">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CTHT_0037370</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 20">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 19">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="7 19"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694161.1">
        <property type="nucleotide sequence ID" value="XM_006694098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7X8"/>
    <dbReference type="STRING" id="759272.G0S7X8"/>
    <dbReference type="GeneID" id="18257775"/>
    <dbReference type="KEGG" id="cthr:CTHT_0037370"/>
    <dbReference type="eggNOG" id="KOG1367">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025427_0_2_1"/>
    <dbReference type="OMA" id="DMIFDIG"/>
    <dbReference type="OrthoDB" id="275353at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000019">
        <property type="entry name" value="Phosphoglycerate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000031">
        <property type="entry name" value="Phosphoglycerate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="entry name" value="Phosphoglycerate kinase, N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406:SF0">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="12 19 21" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 19" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="24"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="64"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="373"/>
            <end position="376"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00016471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EGS21865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="418" mass="44670" checksum="74ADEA413F3A7C07" modified="2011-10-19" version="1">MSLANKLSIEDVDLQGKRVLIRVDFNVPLDADKKVTNNQRIVGALPTIKYAIEHGAKAVILMSHLGRPNGNPNPKYSLKPVVPELEKLLGKSVTFAPDCVGPEVEEIVNKADNGDVVLLENLRFHIEEEGKGTDAEGNKIKADKAKVEEFRKGLTKLGDVYINDAFGTAHRAHSSMVGVDLPQKAAGFLMKKELDYFAKALENPKRPFLAILGGAKVSDKIQLIDNLLDKVNTLIICGGMAFTFKKTLYGVSIGNSLFDEEGSKTVADLMKKAEKNNVKVVLPVDYITADKFDKDANTSTATDATGIPDGWMGLDCGEESVKLYKAAIEEAETIVWNGPAGVFEFDKFASGTKATLDAAVAAAQNGKIVIIGGGDTATVAAKYGVEDKLSHVSTGGGASLELLEGKALPGVVALSERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0S843</accession>
    <name>G0S843_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative acetoacetyl-CoA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0029310</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693386.1">
        <property type="nucleotide sequence ID" value="XM_006693323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S843"/>
    <dbReference type="STRING" id="759272.G0S843"/>
    <dbReference type="GeneID" id="18256969"/>
    <dbReference type="KEGG" id="cthr:CTHT_0029310"/>
    <dbReference type="eggNOG" id="KOG1175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_3_3_1"/>
    <dbReference type="OMA" id="FTRIPFH"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921:SF4">
        <property type="entry name" value="ACETOACETYL-COA SYNTHASE (AFU_ORTHOLOGUE AFUA_8G04770)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="3">
        <location>
            <begin position="47"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="122"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS21090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="670" mass="73435" checksum="A585E4FBCD792216" modified="2011-10-19" version="1">MAVGQAEDQQVAVPRKLWEHPNPESTYLYRFIQDINRKHNLQLKTFADLHAWSIANRSAFWAAVFEDADYIYEGRYTRVVDESLPIDAVPRWFEGVRLNWAENMLYSHPTGTPSTTRSTAGKEDSRIAITEVREGASEVREVTFGELRQQAGRLARAMQARGVKKGDRIVVVCANSVETLVVFLATTWLGAIFSSSSTDMGVKGILQRAVQVNPKLLFMDDGALYNGKVVDLRGKMAEVVEGLKQCSNFNGVVSIRRFAKAYDISKVPNAETWDSFMAAAGPDPKAPAPEFVRIPFHEPFLICYSSGTTGTPKAIVHSIGGVLISMYKEGHLHEGTDADTVTLQYTTTGWIMYLSSIAILLQGGRAILYDGSPFQPDVGILVRVASQYGATKLGISPRWMFEIAKRGLRPREMADLSRLRTVTSTGMVLSDQLFEWFYDEGFPPNVHLGNISGGTDIAGCFGIMNQLTPVYVGGTQGPSLGVPVAIFDSLLPDGAPGKEVPPGTPGELVATAAFPNIPCFFWADNKPTSGSGPAAPGTRYHSSYFARFPHVWAHGDFCVVHPVTGGISFLGRADGVLNPSGPGHKFDEKLVKEVKEAIATDLSKRHVPKYVFETPEIPTTVNLKKVELPVKQIVSGQIIKPSGTLLNPQSLQYYYQFAKVEELVNSKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0S879</accession>
    <name>G0S879_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0037870</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694209.1">
        <property type="nucleotide sequence ID" value="XM_006694146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S879"/>
    <dbReference type="STRING" id="759272.G0S879"/>
    <dbReference type="GeneID" id="18257825"/>
    <dbReference type="KEGG" id="cthr:CTHT_0037870"/>
    <dbReference type="eggNOG" id="ENOG502S2BG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_388825_0_0_1"/>
    <dbReference type="OMA" id="QCNFEVG"/>
    <dbReference type="OrthoDB" id="5414836at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38122">
        <property type="entry name" value="GLYCOPROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38122:SF1">
        <property type="entry name" value="GLYCOPROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409009" evidence="2">
        <location>
            <begin position="19"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="562"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="604"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS21913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="710" mass="78003" checksum="72CF8F7494EB94C3" modified="2011-10-19" version="1">MKLSTIFGALALVPAVAGTPPHEDYGHSKKCTTTITEYTTSTKTTGTCKPTTSWKTKTEVVPTTVWETKWKTETKYVPTTVRKTDTVYVPTTVWKTKTETEYVPTTVTDTQHVPTTVWKTTTETDTTTLWKTKTETETETEYVPTTHYEPTVTTTTKKIKITKTIVKTDTVYDTSTTTVHQPTTTTETEYVPTTATTTSTKKIVKTIIEVNNVTQTITNTATTTLFETEYVPTTTTATETETFVTSYPVTETVTDSTTKIKIKWKTTTFYSTHVVVKTTVRPVTHTITNVIPGPKVTQTVTHYVPPVTVTTCPATTTSVCPVPTIAPYINSNNNYNRRELVGRTGKKNDQKLKPGEQLLWGCSPGRVCDLPKPGTCTIWEDLPPKEWTCPAKYCVPAPPVPKVEWPEGATERYYPLIKGYFNLDPRAFGLTYDIFQPPKNHSKRQDYLDETRVHPDCYGTCNDANLEAQNFGLKPDLCEEEVSPFLTYYHRCVACVAKNADNMIETMRAYLEGAFNNYLGYCNIQPPYYATQAPTEPPPQTQVTETPDISTTSQEPPNTSATPVPIETSTESETPTPTPEPSVETPTPTPTPTPTPTPTPTPEPSNSSETATPEPTTGTPTPSSSSESETLEPTAESSSSTSSSSSSSTETPTPSEASLPPVPTPNEVGTTQFITPSARPTDILVTAGAGKVAFGWFWHMMAVIAMIMML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9E6</accession>
    <name>G0S9E6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0045570</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694942.1">
        <property type="nucleotide sequence ID" value="XM_006694879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9E6"/>
    <dbReference type="GeneID" id="18258595"/>
    <dbReference type="KEGG" id="cthr:CTHT_0045570"/>
    <dbReference type="HOGENOM" id="CLU_1618811_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="164" mass="18168" checksum="86D57B3A882AE294" modified="2011-10-19" version="1">MVHATPNKSVERGRPDSPDFNDLGNYTWTIECARAVPIMKVKPKLVEIPPRKGHIYGQSVPQPQPGKSSGNLKGSTTVSNRHPWKPVSLSKDFGEVAESLTLQAHKPRIFQSGLQAAIYATLYPERRRKLQESLDFDDGVEHTDSGYLEDAGDSEKGDKGAHEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9M0</accession>
    <name>G0S9M0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Serine/threonine-protein kinase TOR</fullName>
            <ecNumber evidence="17">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CTHT_0046380</name>
    </gene>
    <organism evidence="23">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Vacuole membrane</location>
            <topology evidence="14">Peripheral membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="17"/>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695016.1">
        <property type="nucleotide sequence ID" value="XM_006694953.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S9M0"/>
    <dbReference type="GeneID" id="18258676"/>
    <dbReference type="KEGG" id="cthr:CTHT_0046380"/>
    <dbReference type="eggNOG" id="KOG0891">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000178_7_1_1"/>
    <dbReference type="OMA" id="MRQHSAK"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016242">
        <property type="term" value="P:negative regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901992">
        <property type="term" value="P:positive regulation of mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031137">
        <property type="term" value="P:regulation of conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905356">
        <property type="term" value="P:regulation of snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05169">
        <property type="entry name" value="PIKKc_TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000020">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.150:FF:000001">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000371">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000446">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000487">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000582">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000004">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.150">
        <property type="entry name" value="FKBP12-rapamycin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009076">
        <property type="entry name" value="FRB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036738">
        <property type="entry name" value="FRB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024585">
        <property type="entry name" value="mTOR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026683">
        <property type="entry name" value="TOR_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF9">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08771">
        <property type="entry name" value="FRB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11865">
        <property type="entry name" value="mTOR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01346">
        <property type="entry name" value="DUF3385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01345">
        <property type="entry name" value="Rapamycin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47212">
        <property type="entry name" value="FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9 17 22" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0469">Meiosis</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 17" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="FAT" evidence="20">
        <location>
            <begin position="1244"/>
            <end position="1847"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="19">
        <location>
            <begin position="2022"/>
            <end position="2338"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="21">
        <location>
            <begin position="2408"/>
            <end position="2440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="2300"/>
            <end position="2332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="2349"/>
            <end position="2377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="2363"/>
            <end position="2372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU364109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EGS20131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="2440" mass="276953" checksum="1BFEFF00A4792AAF" modified="2011-10-19" version="1">MSSVIRDTVSSALDQYIKDARSRSHGEDQRKRAARQVRELVHIAKQEMSAEQFQRFFDTVHQKTMALIQSTDTYDKMGGVYILDALVDFDGIEPALKLSRFQQYIGTILRGKDLNPMQPAAVVLGKLCKPGGSLISELVDAEVQTALEWMQSDRVEERRYSAVLVLRELARNCPTLMYPYVGFVFDHIWIGLRDPRHLIRATSSETVSACFKIIRERDQDLKQEWMDKMFAEAIKGLKTNSVEYIHASLLVLKELLEQGGMYMQSHYQEACDIVYRHKDARDPAIRKTVVFLIPDLANYAPSEFSATYLHKFMVYLTNMLKKEKERNDAFLAIGNIANSVKSSITPYLDSILVHVREGLSVQSRKRGSVDPVFDCISRLAVAVGQTLSKYMEALLDPIFACELTPKLTQALVDMAFYIPPVKGIIQERLLNMLSKVLCGEPFRPLGAPYSTPIPSIPPIPKDPKDPSVHERGKAEVKLALNTLGSFDFSGHILNEFVRDVAIKYVEDDDPEVREAAALTCCQLYIRDPIVNQTSYHALQVVAEVVDKLLTVGISDPEPKIRQTVLTALDERFDQHLAKAENIRTLFFALHDEQFAVREAAVTIIGRLTRHNPAYVIPHLRKTVIQMLTELEYTDVPRSKEESARLLSLLTQHAQDLIKPYVSSITEVLLPKASDPTPSVAATILQAIGELCAVGGAEMLAYKDTLMPIIIDALQDQSAPIKREAALHTLGQLASNAGYVIKPYLEYPQLLEILQSIIRGEPQHGPLRQETIKLLGILGALDPYKYQQVEERAPQTQRRPEATQQTDVSLMMSGLTPSQEDYYPTVVINALLHILQDQSLVQWHGNVVDAIMSIFITLGLKCVQFLDRVVPAFIGVIRASSPSRLEFYFNHLSRLVTIVRQHIRVYLPDIIALLQEFWNTSSSLQTTILNLIESIARSLEGEFKIYLAGLLPLMLGVLEKDVSTKRQPTEKIFHAFLVFGSSAEEYMHLIIPILVRLFDSPAQPAFLRKSAIETIGKLSSMVNLNDYASKIIHPLTRILAGQEPSLRVAALDTICALMLQLGRDYLHFEHTVDKIITMYGIQHANYDKAVEKLKKGEALPQNLAPRFEDDVIEQYSPENNPPKKLDLNPMHLKQAWDTKGKSTKDDWHEWFRKFSTTLLSESPNHSLRACASLASNYQPLARELFNSAFVSCWNELYEQHQEDLITNIENTIKSENVPPDLLGQLLNLAEFMEHDDKALPIDIRVLGREAARCHAYAKALHYKELEFLQDHNSHAVEALIVINNQLQQSDAAIGILRKAKAYKDGIQLRESWFEKLERWDEALNFYCQRERELPQDQPTPVDIVMGKMRCYHALGEWESLASLAGKTWANSSPEIQRRIAPLATTAAWGLGKWDSMDIYLQSMKRFSPDRAFFGAILALHRNQFREALTCIEQAREGLDTELSALVSESYNRAYQVVVRVQMLAELEELIIYKQSGPEKRATLRATWETRLKGCQRNVEVWQRILRLRSLVLTPQENMHMWTKFANLCRKSGRMGLAEKSLKQLIETDGPLESVIPYWHDRPTTPATERIALPIVYAILKYQWAVGQQPGVRTSDRGIAERTLYCLRRFTEETAQRLEAARLQIFASQQAANGGVMDGLGASRFAVDIDDPALLNPEAQRQWVEQTVLLAKCYLRQGDWIIALNKNDWQLTRRADILDCYRNATRYNSRWYKAWHAWALANFEVVQALAPRKESIGLSEHSIVTDYVVPAVRGFFESIALSSGSSLQDTLRLLSLWLTYGGYQEVINAVTEGISHVSVDTWLEVIPQLIARINQPNKRVQQSIHSLLSDVGRAHPQALVYPLTVASKSRQSTRRSKTALAIMESMRAHSPRLVEQAEIVSRELIRVAVLWHELWHEALEEASRLYFGDKNIQGMFDVLEPLHELLEKGPKTLREISFAQAFGRDLADAREWCRNYRQTGDLADIGQAWDLYYAVFRRISRQLPQMTSLELTYCSPDLLAARDLELAVPGTYRSGQPIVRIMAFEGTFSVISSKQRPRKLDILGSDGKTYTFLLKGHEDIRQDERVMQLFGLCNTLLANDSECYKRHLNIQRYPAIPLSQNSGLLGWVPNSDTIHQLIREYRESRKILLNIEHRIMLQMAPDYDNLTLMQKVEVFGYALDNTTGQDLYRVLWLKSKSSEAWLDRRTNYTRSLGVMSMVGYILGLGDRHPSNLMLDRITGKIIHIDFGDCFEVAMKREKYPERVPFRLTRMLTYAMEVSNIEGSFRTTCEHVMRVLRDNKESVMAVLEAFIHDPLLTWRLTNPASPPGPRFGSEREQALAGPQGARTRRPSILDGPIAPTEYLAQTGGVESMMGGPGARARARTNSSVAPSSSMSNTNGAHEMPEVQNARAIEVLDRVAQKLTGRDFKPHEELNVPDQVNKLIIEATKLENLCQHYIGWCSFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9P0</accession>
    <name>G0S9P0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0046580</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695036.1">
        <property type="nucleotide sequence ID" value="XM_006694973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9P0"/>
    <dbReference type="GeneID" id="18258696"/>
    <dbReference type="KEGG" id="cthr:CTHT_0046580"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="OMA" id="TGSHMES"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="MFS_trans_sf"/>
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        <property type="entry name" value="Sugar/inositol_transpt"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
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    </dbReference>
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        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
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    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="10"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="481"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="504"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="SAM" id="Phobius"/>
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            <dbReference type="PROSITE" id="PS50850"/>
        </source>
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            <dbReference type="EMBL" id="EGS20151.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="516" mass="56870" checksum="B38ACE276B5DD01F" modified="2011-10-19" version="1">MYQASNVYFICSFAAIGGGLFGFDISSMSGVLGTQAYKRYFNNPVSYAQGGITASMPAGSLLGSLVSSLLADRYSRKVALQISCVLWIMGSILMAAAQNIGMLCFGRVVCGLCVGIASSVVPIYQSEIAPREIRGRVVSLQQWAITWGILIQYFIQFGAAEGIGGGSKDPNQPTAAFRIPWGVQAIPAFVLFVGLFFFPYSPRWLASKDRWDEALKVLASLHGKGDVNHPKVLAQYQEIEEALRFEREQAVSSFKVYYIVYIMEGAQMASPLATASIQYVINVVLTLPAILFLDKWGRRPSLLLGSFGMMTWLFISGALQQYYGQPNTAQTRTPQNADITWLILNNRPVSSAIVACSYLFVATFATTWGPVSWTYPAEIYPSKIRAKAVSLATAANWFWNMVLAFAVPPLLWNISYRMYYIFGAFNAAALIHMFLMAPETKGYTLEEMDEVFESGRPAWKRVKGSRLEELERQIEAGNLKVSVPVESSSSDPLPGEPGIEKTATRTNAMETNPRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9S5</accession>
    <name>G0S9S5_CHATD</name>
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        <recommendedName>
            <fullName evidence="6">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0046990</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20186.1"/>
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    <dbReference type="OrthoDB" id="6329284at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ecp2-like"/>
    </dbReference>
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        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
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        <property type="entry name" value="Hce2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408932" description="Methyltransferase domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="445"/>
        </location>
    </feature>
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        <location>
            <begin position="59"/>
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        </location>
    </feature>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="228"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF14856"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="50026" checksum="9ED848C3248AC176" modified="2011-10-19" version="1">MLPLCTTTVVFISMASMVASASPVNFTPAAVTESTNTTTLIKRTQFYPGNQKAGEDDWCEKYQMGQFTRGNSNRAKSADCEAILKDIPTPGYWLITLDDTKAHEKNGRWVQIAKHSTCAFDVRLSKAYKQDRPENMWDFKFGTEDMWWAISNYAWDPDTKDGTPQSLAMGHDTSSLSQQALSSWKANAQAWDAQITPNGNKYWRHLQEPCLRRLLGAYLSKSGGCRALDLATGNGLCARWMASLMDPAGKRDVLATDGAESMLDVARIRVKEAGLEGVVRFRKVDVTSKEDLVGLVRAEGKWDVVLMNMALMDVGEVWILAKTLPHLLRKGGVINHETGEFEILRSIVVREYMNVAPYKGVAVVGQPEKQVGVQHREFLLSCLSEWQIYFHRPMHELFGVFFREGLVMDALEELAFPEEAKEEKVTATVNFTQFPVILAFRLRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9T8</accession>
    <name>G0S9T8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0047140</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006695021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9T8"/>
    <dbReference type="STRING" id="759272.G0S9T8"/>
    <dbReference type="GeneID" id="18258752"/>
    <dbReference type="KEGG" id="cthr:CTHT_0047140"/>
    <dbReference type="eggNOG" id="ENOG502TGDS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_354107_0_0_1"/>
    <dbReference type="OrthoDB" id="5215637at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="420"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="736"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="581"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="685"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="736"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="776"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS20199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="793" mass="83001" checksum="1E604C4092D0127F" modified="2011-10-19" version="1">MVMESLEVRAAKISAGKFRAGLLALALGVNRYIVRVKVVYDFLEESRPGQSIKGLADTRQVASCSLETISMMAAKFNTFLGLITLLAVALGSFGGPTEPAPSSLEQVHPRFVPTASITGGNVTCFWPNGEPAPVARPCLDGFGNPTGLCCAYGHHCLNNSLCMVKGGLGTSKSNIDNGNGNDNGKNSFYRGACTDPEWKNPGCPGFCTGLADNEKSHFIMAHLCGQGPSRTHWFCDGFKPSSNCLLTNGHFALSDNLTVYATAKELLKSSDSDGDHSEVPPPPPQPVPPMATTQPAHTDHPIHTVGPNEPPVSTAAPVPLVGSSTVSVPAPTLSKPVPPNESSHLAPSPSTEALPAKPTDTNPEDHGSTSFVPVPPITTLIPNPAESDTASHTSEIPAETSTFTELARPTSTPNTLTTGVGIGLGVGIVATLLCIGVIALTIYLRRRRKLKRLGLWGVPAAESPPPLSESTRTTGLRNGTPTTDGFGCREERDKHKRIAEKSLALARAGFRVGIGYEEHEMDNLRSRDPPGIQQAVERAQHANAQSNRPGSAPHGPGSALNGYVPQSRGPPPAGPRPGPPHHSSGAGYPVVCPVPTPGPGPSRPAGPRPGPLASSGPGYQGNHRSQGPVPRQASYNGGPGQNHSPSQRLPTRRPAPSHGPGPVGLGSVHVSFSHGAVRDPGSVGPKNNSHPTSPETIHAQEGRMHTLSPVAGVVFNPIRLQEGARAYVRDQAQRGGNANANAMQGQAQDGHHREHPHPDHHQGQGYAPSESGPVCDRGHGHHNDHDGTGWPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0SA23</accession>
    <name>G0SA23_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lactase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0040740</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694480.1">
        <property type="nucleotide sequence ID" value="XM_006694417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SA23"/>
    <dbReference type="STRING" id="759272.G0SA23"/>
    <dbReference type="GeneID" id="18258112"/>
    <dbReference type="KEGG" id="cthr:CTHT_0040740"/>
    <dbReference type="eggNOG" id="KOG2024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002346_0_2_1"/>
    <dbReference type="OMA" id="WCDHGIL"/>
    <dbReference type="OrthoDB" id="408320at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005990">
        <property type="term" value="P:lactose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000018">
        <property type="entry name" value="Beta-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004199">
        <property type="entry name" value="B-gal_small/dom_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050347">
        <property type="entry name" value="Bact_Beta-galactosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023230">
        <property type="entry name" value="Glyco_hydro_2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032312">
        <property type="entry name" value="LacZ_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46323">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46323:SF2">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02929">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16353">
        <property type="entry name" value="LacZ_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01038">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00719">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta galactosidase small chain/" evidence="8">
        <location>
            <begin position="748"/>
            <end position="1040"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS19595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1040" mass="119002" checksum="3FDD26E9546D96D5" modified="2011-10-19" version="1">MSQGTLPSDLPGWVRSSEPQAHVFPPSVPDWNNLKVLHRNTLPPRSHFFVYKDIEDARKGELALAKSQLLSGQWLFSLSKSPYDGTVDFYKYTPQELADMPGWGTQHNRIMVPGFWQLQGYGRGPQYVNYNYPFPVDPPRVPIDDNECGRYVTCFKLDPVEDKDHQIRLRFEGVDSAFTVWVNHRDVGYSQGARNPSEFDITSFVRFDGVNLLHVEVYQRCDGSYLEDQDQWRFSGIFRDVWLHKFPKIHIEDFHVQTLLDDKYQDATLLVEVQLNGHATVELSLEELHKTKVTEENKKPEVIIVAQATKEGSGTITFQVPVANPRKWTAETPYLYRLILNVPGCVVAERVGFRKVELLDGVFCVNGQPVKLRGVNRHEHHPKYGRTVPYDFLKADLIQMKQYNVNAIRTSHYPNDYRLYELADELGLWILDECDLECHGLFVVGGDGSQYTSNNPDWEEAYVDRARQMVMRDFNRPCVVLWSLGNEAGYGRNHAAMYKWIKGVDKSRLVHYEGDWNAESADILSRMYFSVHDMEKFGKEQSWTKPVVLCEYVHAMGNGPGNIQEYINLFYQYPRLMGGFVWEWANHGLATKTKDGIPYYAYGGDFGDEPNDYNFVMDGLCYSDHRPGRGLVEYKKAIEPVQTLGVEGTRVRIVNRYDFLTLDHLECRWAIISDGTPGIVEDDLPIPKGIQPHTEALIEIPKLAQHLPPDAHLNLTFSLAEATNLRLTYSLSAPKPVKIEMPHSSQLLISGGSSVAWKFDLRIGGLVSWEIVDTRNASRSFNILTEPIVFDIYRAQTDNDRGCDFGRNWTGRRLHQAKQHGVESSWAYKEDGTLEIMSKTRIMPPSLNWALEVTATYRFTNDAVGIRAHAKPTGNGLPRAWGRLGLVTAVEGCDHVRWFGRGPDESYCDKKLSQLVGTWELPADELVTEYEFPQENGNRTDVRWVELWTDGRRSLPGRRRLLRARYGAFEGASFSVLPYSARDLDDCGHPYELHDRWRKDRVVRLDWMHHGLGTGSCGPETLPQYALDAGREYDVEVVLE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-06-24" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0SA56</accession>
    <accession>G0ZGV4</accession>
    <name>MLP1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein MLP1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">MLP1</name>
        <name type="ORF">CTHT_0041070</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the structural and functional organization of perinuclear chromatin. Associates with the nuclear pore complex and form filamentous structures along the nuclear periphery.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 7">The nuclear pore complex (NPC) constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. The 55-60 MDa NPC is composed of at least 28 different subunits: AMO1, ELYS, GLE1, GLE2, MLP1, NDC1, NIC96, NSP1, NUP133, NUP145, NUP152, NUP159, NUP170, NUP188, NUP192, NUP37, NUP49, NUP53, NUP56, NUP57, NUP82, NUP84, NUP85, POM152, POM33, POM34, SEC13 and SEH1. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JF276299">
        <property type="protein sequence ID" value="AEL00692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694513.1">
        <property type="nucleotide sequence ID" value="XM_006694450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SA56"/>
    <dbReference type="SMR" id="G0SA56"/>
    <dbReference type="DIP" id="DIP-61564N"/>
    <dbReference type="IntAct" id="G0SA56">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0SA56"/>
    <dbReference type="TCDB" id="1.I.1.1.2">
        <property type="family name" value="the nuclear pore complex (npc) family"/>
    </dbReference>
    <dbReference type="GeneID" id="18258145"/>
    <dbReference type="KEGG" id="cthr:CTHT_0041070"/>
    <dbReference type="eggNOG" id="KOG4674">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001250_0_0_1"/>
    <dbReference type="OMA" id="HAQQNYE"/>
    <dbReference type="OrthoDB" id="343070at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057974">
        <property type="entry name" value="NUA/TPR/MLP1-2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012929">
        <property type="entry name" value="Nucleoprot-TPR/MLP1-2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057577">
        <property type="entry name" value="Nucleoprot-TPR/MLP1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898:SF2">
        <property type="entry name" value="NUCLEOPROTEIN TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898">
        <property type="entry name" value="NUCLEOPROTEIN TPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25481">
        <property type="entry name" value="Nucleoprot-TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25785">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07926">
        <property type="entry name" value="TPR_MLP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000433195" description="Protein MLP1 homolog">
        <location>
            <begin position="1"/>
            <end position="2085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="365"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="934"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1482"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1567"/>
            <end position="1591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1816"/>
            <end position="2085"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="44"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="399"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="568"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="675"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1232"/>
            <end position="1667"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1744"/>
            <end position="1799"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Nuclear localization signal" evidence="4">
        <location>
            <begin position="1159"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1482"/>
            <end position="1503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1504"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1574"/>
            <end position="1584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1817"/>
            <end position="1827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1843"/>
            <end position="1858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1910"/>
            <end position="1974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1982"/>
            <end position="1994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1995"/>
            <end position="2016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2028"/>
            <end position="2040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="2041"/>
            <end position="2051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="2076"/>
            <end position="2085"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="O74424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q02455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="21784248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7">
        <source>
            <dbReference type="PubMed" id="21784248"/>
        </source>
    </evidence>
    <sequence length="2085" mass="231069" checksum="0D7256FEA6B938F2" modified="2011-10-19" version="1">MAAAEVDLGYLSAQANISQVDLETVVSAPTADLVKSVLAAVLSKIRELEQDKFHLNVELEGAIRGAESRCEQFKATSDKALKEVEELRQKLQSEESARRTLENELQTLKSSGSASLSEIETLRARIASLETSNRETLAIVDSKASANAALSEELQKQHQKILKLNQEINNLNQAVQTAQTAANSAKYREESLKQELELAKKNNDWYDNELKTKAAENLKIRKEKGAQIAQLQREKEDALSTIQSLQKTEQQLRKRLQEAQSKAEEALTKVQQLQESAARAEESFRQELESSKRLVELKDQQAQTHRNRLKEVELRLEKVKDDSAEEIRRVRRELEQAKEDLSQSEQQVQDLQSEVDRLRTLVESHDGVPGSVPQTPRANGSLLARPSSPFGTPASLRGKATQRATETLEELLKVKAQLASEQRRSQKLQEDLDDAVSMLEAKLPEIDELNAESERLRNEVIQMSEIMQQSYEERDAAVKAARKAEAAASQAQAEVKILRAQLRDLSTQIHVLIFNAHAKEKGMDQLTEEEIAQFERLQRGEISEGALEDLSDTHRFITERFTVFKDIYELQQKNEELLKLTRELATKMENEEALAAQRQAAQEHEEVQQLRATVAALQDEVRSITIRMKSHMTERDMFRRMLQQRATPAEIQKVLGTQADGEQREVLPSVEQPHANEAQLAAALRELQAQFDAYRNDQVTDRNAMREQIDKLSGEKGSLQSEVTKLSSQLTLATERYNMLESNFKALQSENQELQKRNQSLSEAAAKQDIRTQQVAEDLVEARGLVESLRSENANLKAEKALWRTIQERLTQDNESLAQEKTRLNGLLASQQSLLNERELSEAETKRRLQAQIDSLEAELSTTKRKLSEEIEESKKVQLRKEFDAQQFQKRIDELTSMISQVKEENIQVKTTRDHLQARVSELEIEVRNAQERAERLRPLPTPRAPAAAEQPSEEAQARIEELEGEVQELKNNLDLLTVQLEHAKQQAEQFKQLSKDMEEELSSLNESHEQYRQEMDAALASKANTINELQQRVEALTAELSNTNNELNMLRDSQSDVARKFEEKERMLNAEIARLKDEEERYKEAARFHQQDLRAQAEIATKAQQDYEQELVKHAEAAKLLQQLRAEHNELKTQAAAWRAEADSAKISLAQSEQSWEERRQRLEQEIAEIKARRDDMAAQNKLLHQQLDAVTAQITALQQKRTQGDVSGEAAAPAIADMATEGLRELNSYLRREKEILEVQYDIKVQEAKRLQQQLEYTQSQLDETRLKLEQERASQADSTRTSLTHKELMEKLNELNLIRESNVTLRNENQRAQALLEQKAARITELEAKIQPLEARIAELELDKGFKEEEIRQLQEARDGLQKRIETILSKYGQADPQEVEQLKAMIAALEGERDVLKQSEQALQQKVKEAENALETKTNEWKATREKLAEDFKARFRNMKTQRDEATNEKNTLQATLDGVKEQLAALEKELETTKQQLATATEKNTSLQQQLAASSTEQPAAAPVSAAPSDQINELTQQLQAVKQQLESVSAQKAAAEAQVEQLKQELAAAIAERDRALAATSGGDVATAETSVSAQPSAGLSDEERKALEEKIAAAEAKAAEFEKRAKELEEQADNIVKQRSDKMKTALNKKLQESKEAMEKQIQEEKAKLQAEFDLKLQQELAIIKAEQQTAGPQNGVPATPVKTEANAAPGTPVPDITNMTDAQIREAVAKNPTISAIVKSNVKRMVAAETKKIKEEIEAALKAEYEQKITNAKEQATALTEKKSALRINMLDRQHKTAQAKLAIVETAAKETPQKPVVEVWNIAKDAKPPAPAQAPAPAPASAAPSPAPTPAQPVAPATAAPAAPAQAPSAAPPKEETKQEAKTTTAAPPSAIPKPAVNPFTAPLNPFGAPAPTSNIPAPPQAGQQPQQTQPQQPQQPQQQQQQQKGQQQQQQQQQQQQGQQQQQQGQQQAGGQNQPQRMGIPVPAGRGGPGGARTARGLYQAGPRGARGGRGGGFVGAGRGAGGAAGGLNPNAGEFTPGGATATAAAAAAAGGAGGSAGAGNAGNKRQRDGEGGQPQGERGGKRARGGGGGGGGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAE4</accession>
    <name>G0SAE4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7357 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0041980</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694601.1">
        <property type="nucleotide sequence ID" value="XM_006694538.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0SAE4"/>
    <dbReference type="GeneID" id="18258236"/>
    <dbReference type="KEGG" id="cthr:CTHT_0041980"/>
    <dbReference type="eggNOG" id="ENOG502SF1H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002397_0_0_1"/>
    <dbReference type="OMA" id="RSHDESH"/>
    <dbReference type="OrthoDB" id="5368821at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055781">
        <property type="entry name" value="DUF7357"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF12">
        <property type="entry name" value="AT HOOK TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24054">
        <property type="entry name" value="DUF7357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7357" evidence="2">
        <location>
            <begin position="6"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="855"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="949"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1170"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1305"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1391"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1450"/>
            <end position="1690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1718"/>
            <end position="1802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="556"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="583"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="617"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="674"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="762"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="799"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="814"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="874"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1007"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1052"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1178"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1220"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1237"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1305"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1318"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1394"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1591"/>
            <end position="1603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1612"/>
            <end position="1623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1632"/>
            <end position="1641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1651"/>
            <end position="1685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1750"/>
            <end position="1764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS19716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1802" mass="198441" checksum="9966EDF3FA9A9EA3" modified="2011-10-19" version="1">MTPNTLRLRLVVRRHALPDVRIVFPVRLDNDPTIANLLEQVNDVIPLESYESSWGLEDYAVELENGFELLHFQSVGEVLKEDEEVFIRPLDTNDYRKRRLAGRHQISAQGRRLYDGVAFGRPRLKTSRDRPPVEIPPLKRRRISYDPEEDQDDQYDDYDYDNGYQDEGQEQDEQGQPRLLLTERGEGHRKKRVRVRSPTPEEEDEQDREYDGSSEHEEHYSDEDNDSHYSESEGCYHSGRDDASIQSELEDELRGLRADQGEPSPRLPSRSSSHSRFHSSSQHEDQDEDLDKDEPHESPTESDLNYSLSNIIHLLRKTFPGATFETCKKALRDSDGDLRETYDRLQEKYKPKISRRGLLMLDEIKGWSTRHVSLKGRVGNVKKIHSKEEEDAQREESEGDEHQQQQRKKKILRKIKKKKGKKAQKEAEDAAPENEESDVESVSSFIKHFDKHGFPSGSVLEGTAAAQMVEQMRKEGKEVKMPVHMRFDEDLSDESAASEKSDDGTSESHRDSEDSGPEEQSSKRFVEGPGTEESDKESVSSKSQSESENESESESESSSSSSNESSDSDLSSDGDNHSDSSDSESSSSSDKSSKSSKSSKSDNSESSDRSSHRVRSRSASSSSSSSSSSSSSSASAKPSLSGPSKSSSLNLSGSSKSDSSSSSESDSDSDKSVRSSSSESVSAADSGSSVSSSSESDSDSDSSSSSSSSSSSGSSESESESDSSSSSDSSSASEKESKKSHSKATSSPTKARVSKSPEEARASTQSKSQDLPASAPFSRDTNQVPQGQQMPVPPGHGKAATRKRNARRRTLLRAKKEEATRRAFEGLSVSGEGDNMEVEEYGSIEERKRELLKSLLSSEGQLGAREQSDEQATKQDGNSQAASSPPRPLTKSDTKPSKEAAQTEQKADDPDAWRSKIIYRAVECVQEGVELSEPPFPFKQRWDPQQQFWVSKDKYGQNGRGKRKQQGGYEDEESYAGVKRRRYTQEEEVEDFEEKRGGKHRHPDELAAGEDELNYDDEPQEELNYDEPEQERNYDYLPKATSQDESEEEDLPFPPADPSVLPPFNPDTAIPGMILTWNQLILSKATSWQPQICRRTGKIVEVQGDGLLKVRLAKRDRWVDMNKREYDLEGNRVWGRFEAPEMDEEDEEEMERGFRMVNVVDMMDARVLKGAKGQPQGKSEDKQKVDAENAETEEVKKGETDKTQAEMTNENEAEQAQKPWDQKLDFEKADTPKAVPSTATEGASKEASSANSPDSKPQDDTLPAQPASAVVEISEDRHRDISQLISEAGFRKDLDPSLLTKSTTVTLDLSSPSRQADSSAPVSAGAANSGASSPRKGLGPRKELNPILRENSPLKSPRKAASQVNIWQSSNLNDVDSQPVILESFKAFSDAVTEQEHQDKESGHMSYPKLEVPPSDPVNVRSTRQVVDPDFSIELGGELGEETVVVTLPTPKKASKKEAELNADVPMPTKEMNRTADAAKTATDESPLCLKQGCKSKGKGSKLISDDEELLSPKKERKVKTALRLSGVDDIDHDLSPSPCSPLPDGSYSDSNLPMLPIKREGVKTKSSKKDKKLDSDNDDGDSYEKAMRQLESSSFISDPISDNDNDEFKARGKQSHLVKKLTKSIERPATKKSQPSTRLPSPTKPVGNARSASISFTSTAKNSSAVGSQISRGTSTQPHSQPIPASQFVIPEGSQVISLISSSPEPEFEPLEEHYAEEDIDDTWEPGRDIVGSGWVSKPATSKKGTGRAVPPSSNFPSASAPAKRNAAVLSSSSSQPVGGTSASARKAGTASYKGSKKVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAH4</accession>
    <name>G0SAH4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Class E vacuolar protein-sorting machinery protein HSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Class E vacuolar protein-sorting machinery protein hse1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CTHT_0042300</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the STAM family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694631.1">
        <property type="nucleotide sequence ID" value="XM_006694568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAH4"/>
    <dbReference type="STRING" id="759272.G0SAH4"/>
    <dbReference type="GeneID" id="18258268"/>
    <dbReference type="KEGG" id="cthr:CTHT_0042300"/>
    <dbReference type="eggNOG" id="KOG2199">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010104_1_1_1"/>
    <dbReference type="OMA" id="QVYRDWW"/>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21386">
        <property type="entry name" value="GAT_Hse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11805">
        <property type="entry name" value="SH3_GRB2_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16978">
        <property type="entry name" value="VHS_HSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF3">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="15">
        <location>
            <begin position="17"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="14">
        <location>
            <begin position="226"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="178"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="382"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="186"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="483"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="513"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="564"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="605"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="657"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="675"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGS19746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="696" mass="75519" checksum="0DE669A1F87D5ACD" modified="2011-10-19" version="1">MFRAAAAGPYDEAINKATDENLTSEDWGAIIDICDRVSADPNGPKESVQSLIKRLAHRNANVQLYTLEVANALSLNCGKNLHRELSSRAFTDALLKLANDRNTHNQVKVKILERMKEWSDMFKSDPDLGIMQDAYYRLKQSNPNLEPPAAPQKNQLTEADRLKEEEELQLALKLSLQEEERKKQKQQQPQASSSSAAAGSSSSAAQQQRQQQSTSGQPVPSGTTAATVSRVRALYDFVPSEPGELEFKKGDVICVLEAVYKDWWRGSLRGKTGIFPLNYVEKLADPTPEELAREAQMEAEVFAEIKNVEKLLALLSSGNTLREEDNEEISRLYHQTLAIRPKLIKLIEKYTQKKEDFTQLNEKFIKARRDYEALLEQSMSHSYQQYPARPQGYPPAGPGYSVPTQEPQRYYTPAPTQEPQYPPSSPPPNFQRTPGAAPAPFYVAGAEVPSQPTQPPVQHLPPQPTPQPYPPQQYPQHPQERLPSGSAPSAPIPTSTTSPPPAPHAPYQSPRPQNTSYPPGPQELSTSVYDSPQPTHRPTFPPATYSSPPLDSEDPNKVAASNIPPAPAIPAPQPPVPGSPSQQRHHSGSGPSVAPFGSAYASFHSSAPQQQYGQGQQQGQQSSQAGGAPSAPGAPVDARATLPSRAQPQQYKPYVPPGSAGSGPSAGQSTATPGGPDGMGAGAGTGTESYYRAGTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAM2</accession>
    <name>G0SAM2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Golgi apparatus membrane protein TVP18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0042780</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694679.1">
        <property type="nucleotide sequence ID" value="XM_006694616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAM2"/>
    <dbReference type="STRING" id="759272.G0SAM2"/>
    <dbReference type="GeneID" id="18258316"/>
    <dbReference type="KEGG" id="cthr:CTHT_0042780"/>
    <dbReference type="eggNOG" id="ENOG502S3AC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118698_0_0_1"/>
    <dbReference type="OMA" id="IYAQWLG"/>
    <dbReference type="OrthoDB" id="5591789at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019365">
        <property type="entry name" value="TVP18/Ca-channel_flower"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13314">
        <property type="entry name" value="CALCIUM CHANNEL FLOWER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13314:SF2">
        <property type="entry name" value="CALCIUM CHANNEL FLOWER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10233">
        <property type="entry name" value="Cg6151-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01077">
        <property type="entry name" value="Cg6151-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS19794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="16038" checksum="3106354E967E1D4C" modified="2011-10-19" version="1">MSLKEEFATRNFSIYGQWLGILAMLLCFALGIANIFTFNVFIIIFSVLCLVSSFIILFVEVPLLLRICPTSSTFDNAIRKISTNYMRAGAYGVMALVQWLSIIARPTSLIAAAILLSATGVCYLLAGIKGQAFVGSKTLGGAGVAQMIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAP6</accession>
    <name>G0SAP6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0043030</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694703.1">
        <property type="nucleotide sequence ID" value="XM_006694640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAP6"/>
    <dbReference type="STRING" id="759272.G0SAP6"/>
    <dbReference type="GeneID" id="18258341"/>
    <dbReference type="KEGG" id="cthr:CTHT_0043030"/>
    <dbReference type="eggNOG" id="KOG1558">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027089_1_2_1"/>
    <dbReference type="OMA" id="IFFACKH"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF24">
        <property type="entry name" value="FE(2+) TRANSPORTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS19818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="474" mass="51561" checksum="A17CBC982416FC5E" modified="2011-10-19" version="1">MADNVSVPVSDLNPTEGKPVCGSGDEVGEYDLGLHVAALFLVMAASVLGAGFPVVAKKVSWVKVPTKVFFVCKHFGTGVLIATAFVHLLPTAFGNLTDPCLPDLFTDQYPAMPGVIMMASMFCLFVLEMWLNDKLGGHSHGGPTGYEQSSTPAITVTAPSGLISPPQPANPNPPPRPPRYTAATDFETDYYDDVEYEKKMAQRAYDEKMYEVRREYLYDSDKDIEIRSDMPAWFVVFYEQYVRQKLDMMNTIRTLEKKLSEQAYSRRRTMIGNPGPIAMTTAPPPPPPPPAPAVVDSPYIDVETGQPVDPQVYKRMSMNITLLEGGILFHSVFVGMTISITIDGFIVLLIAMLFHQAFEGLGLGSRIAAVPYPRGSIKPWLLVLAFGTTCPIGQAIGLIARDAYDPNSAFGLIIVGVFNAISSGLLLYAALVDLLAEDFLSEEARHTLTKKDRTLAFICVLLGAAGMSVVGAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAS8</accession>
    <name>G0SAS8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative FAD binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0047620</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695130.1">
        <property type="nucleotide sequence ID" value="XM_006695067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAS8"/>
    <dbReference type="STRING" id="759272.G0SAS8"/>
    <dbReference type="GeneID" id="18258800"/>
    <dbReference type="KEGG" id="cthr:CTHT_0047620"/>
    <dbReference type="eggNOG" id="KOG2495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029131_0_0_1"/>
    <dbReference type="OMA" id="HMGHYAG"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF24">
        <property type="entry name" value="NUCLEOTIDE-DISULPHIDE OXIDOREDUCTASE AMID-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="1">
        <location>
            <begin position="29"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="440" mass="48482" checksum="DB02D6184671FCEC" modified="2011-10-19" version="1">MGSLFQDRACTCPELHVGLDSPTPQQPFRLLVLGGGYGGLSVALNLQDLCRGQAPRCGPAPEEGAPVVERPRFEVEIVIVDERDGFFHTIGAPLALASEDFASKFWIRYDEIPALRSPNIRVLHGSVKSVDPERKVATYLPYAGTEEKQLEYDFLVAATGLRRAWPAVPQSLRRKQYLFEMGDHLRSMTGRKKGVVVVVGGGAVGIELASELKTLHPHLHVILAHSRSQLLSNEPLPDEVKERALELCRDAGLEVLLNHRLERSEPVKGEAGKVTGAVEVVFTNGKTIVADRVVMAVSRSSPNTGFLPREAVDEEGFVKVQGSLRFSPSTIPNSTHHYAIGDIALWSGIKRCGAAMHMGYYAAHNIHQTMQQIVHGKQEEELLELKEIPPMIGLAVGKQAVAYWPENGMIYGEKVLKDFFGEDLGFTICWNHMRLGEEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0SC47</accession>
    <name>G0SC47_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0055900</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695918.1">
        <property type="nucleotide sequence ID" value="XM_006695855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SC47"/>
    <dbReference type="GeneID" id="18259628"/>
    <dbReference type="KEGG" id="cthr:CTHT_0055900"/>
    <dbReference type="eggNOG" id="ENOG502SV77">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090711_0_0_1"/>
    <dbReference type="OMA" id="TANCQVH"/>
    <dbReference type="OrthoDB" id="3786236at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025649">
        <property type="entry name" value="DUF4360"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38847">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38847:SF1">
        <property type="entry name" value="PSEUDOURIDINE SYNTHASE RSUA_RLUA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14273">
        <property type="entry name" value="DUF4360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409115" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="21420" checksum="C61EB06F7CB585D9" modified="2011-10-19" version="1">MGLLSYLTVFLAATGSALAAPAAESPADIAVPTPKITSITYSGNGCVRDPKLSGSFNDPTFTYQGFTLSLPTNTTANCQIHIQASGAGPGWQVALKSSQVKGRLVLTPGTSLTHYTTVFFSQNPTKTSTVSGTVSNDSRNTISRSVTLVSKADSSELAWSPCTGSDGYTGIMNVNFRGVLSGNSRAYFEAQTETWELQWRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCA4</accession>
    <name>G0SCA4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phosphotransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0056520</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695975.1">
        <property type="nucleotide sequence ID" value="XM_006695912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCA4"/>
    <dbReference type="STRING" id="759272.G0SCA4"/>
    <dbReference type="GeneID" id="18259690"/>
    <dbReference type="KEGG" id="cthr:CTHT_0056520"/>
    <dbReference type="eggNOG" id="KOG2877">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035066_5_0_1"/>
    <dbReference type="OMA" id="GMWMYST"/>
    <dbReference type="OrthoDB" id="196717at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000029">
        <property type="entry name" value="CDP-alcohol phosphatidyltransferase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF77">
        <property type="entry name" value="CDP-ALCOHOL PHOSPHATIDYLTRANSFERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015665">
        <property type="entry name" value="CHOPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS19030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="436" mass="48666" checksum="D38296EDFBFC4239" modified="2011-10-19" version="1">MAPSSYNKAAAECVSDDALIHLKSYKYSAVDKSPISNYVMRHYWNAFVELLPLWIAPNMVTLMGFMCILCNVGVLVVMMPDLEGPAPSWVYYSFALGLFMYQTLDNVDGKQARRTGTSSGLGELFDHGIDSLNCTLASLLETATLGLGTSKAGIFTALAPTLPMFFSTWETYHTHTLYLGYINGPTEGILLACLMMLISGYYGPGVWSQPLRELPVATILHFFGLSDSILRDISFIDIWVWFLGLSVLLTHVPFCVYHVVEARLSRGQDILPVFLEWTPMAVFILSSFAWLYSPYSTLAKENHLVLFCIVMAFVFGRMTTKMILAHLTRQPFPFWTVMLWPLVGGAVLANLPYFGLPAVSAAVEYWYLVGYCVFAAVVYFQWAWLVTTSICRFLGINCLTIPAEKQRELMAQQARRKKEGILGGEGPVMGNGRKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCD9</accession>
    <name>G0SCD9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0056870</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC61-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696010.1">
        <property type="nucleotide sequence ID" value="XM_006695947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCD9"/>
    <dbReference type="STRING" id="759272.G0SCD9"/>
    <dbReference type="GeneID" id="18259725"/>
    <dbReference type="KEGG" id="cthr:CTHT_0056870"/>
    <dbReference type="eggNOG" id="KOG3457">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1758596_0_0_1"/>
    <dbReference type="OrthoDB" id="5401193at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005784">
        <property type="term" value="C:Sec61 translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030671">
        <property type="entry name" value="Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016482">
        <property type="entry name" value="SecG/Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13509">
        <property type="entry name" value="SEC61 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03911">
        <property type="entry name" value="Sec61_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="99"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS19065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="148" mass="16045" checksum="D2856A450C8B49F2" modified="2011-10-19" version="1">MASPRATSPAPAGEKGSATGASTSASPGVLGGPRGSSPPPPGGARTAIRRRAAADQKERLANQRPNSTRAAGAGGSSNTMLKLYTDESPGLKVDPVVNNKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCG7</accession>
    <name>G0SCG7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0057160</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696038.1">
        <property type="nucleotide sequence ID" value="XM_006695975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCG7"/>
    <dbReference type="STRING" id="759272.G0SCG7"/>
    <dbReference type="GeneID" id="18259754"/>
    <dbReference type="KEGG" id="cthr:CTHT_0057160"/>
    <dbReference type="eggNOG" id="ENOG502RCV0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_723613_0_0_1"/>
    <dbReference type="OrthoDB" id="5599269at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036286">
        <property type="term" value="C:eisosome filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028245">
        <property type="entry name" value="PIL1/LSP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962:SF8">
        <property type="entry name" value="MEIOTIC EXPRESSION UP-REGULATED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13805">
        <property type="entry name" value="Pil1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="382" mass="41688" checksum="1B646871C8902192" modified="2011-10-19" version="1">MSRNSSEDSRFSFSQWCPPPTSLLMSKLPLTATSQEPRPFNPPLATQQHGNHKHLCHISNILLLFPVLKHTPLQLLPLFPAHPLPQYSPRRTSSLPASPSPHQILTFRDDAVTDLADKLSVLLGEIGRQEAQFACRWEEVRGMLKVVRGTERGVARVRMLGERCRVEVGRLRERVQRDGDANGGGDKGRRLVEAEMELVRLEAEELVAEAQLGGVAILARHGLRLLSLLDSTPLVPGEVRPAFPATAMAQARQILNDAEDDLRTWELSGMDRMLYELSLRPDDVAHGQAVGQHGMAWAQHGRMDMLGDEDGNGGGDGDGDGDGDGGIPEEEGDGDRDEGGAEEDEREEEQTAPPVPPRPRKKGKSKQESLGSESGSEGGVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCH1</accession>
    <name>G0SCH1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Vacuolar transporter chaperone complex subunit 4</fullName>
            <ecNumber evidence="3">2.7.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Polyphosphate kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">SPX-dependent polyphosphate polymerase VTC subunit 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Vacuolar membrane polyphosphate polymerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CTHT_0057210</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2016" name="Science" volume="352" first="986" last="990">
            <title>Control of eukaryotic phosphate homeostasis by inositol polyphosphate sensor domains.</title>
            <authorList>
                <person name="Wild R."/>
                <person name="Gerasimaite R."/>
                <person name="Jung J.Y."/>
                <person name="Truffault V."/>
                <person name="Pavlovic I."/>
                <person name="Schmidt A."/>
                <person name="Saiardi A."/>
                <person name="Jessen H.J."/>
                <person name="Poirier Y."/>
                <person name="Hothorn M."/>
                <person name="Mayer A."/>
            </authorList>
            <dbReference type="PubMed" id="27080106"/>
            <dbReference type="DOI" id="10.1126/science.aad9858"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.75 ANGSTROMS) OF 1-193 IN COMPLEX WITH 1D-MYO-INOSITOL HEXAKISPHOSPHATE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[phosphate](n) + ATP = [phosphate](n+1) + ADP</text>
            <dbReference type="Rhea" id="RHEA:19573"/>
            <dbReference type="Rhea" id="RHEA-COMP:9859"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19574"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the VTC4 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.1" evidence="3"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696042.1">
        <property type="nucleotide sequence ID" value="XM_006695979.1"/>
    </dbReference>
    <dbReference type="PDB" id="5IJP">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.75 A"/>
        <property type="chains" value="A=1-193"/>
    </dbReference>
    <dbReference type="PDBsum" id="5IJP"/>
    <dbReference type="AlphaFoldDB" id="G0SCH1"/>
    <dbReference type="SMR" id="G0SCH1"/>
    <dbReference type="STRING" id="759272.G0SCH1"/>
    <dbReference type="GeneID" id="18259759"/>
    <dbReference type="KEGG" id="cthr:CTHT_0057210"/>
    <dbReference type="eggNOG" id="KOG1161">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4580">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009308_0_0_1"/>
    <dbReference type="OMA" id="NVNAYMR"/>
    <dbReference type="OrthoDB" id="6493944at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016237">
        <property type="term" value="P:microautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07751">
        <property type="entry name" value="PolyPPase_VTC4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14480">
        <property type="entry name" value="SPX_VTC2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.100.30:FF:000001">
        <property type="entry name" value="Vacuolar transporter chaperone 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="20" id="KW-0002">3D-structure</keyword>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="693"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="735"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="777"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="17">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="504"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="504"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="522"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="536"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="550"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="1"/>
        </location>
        <ligand>
            <name>1D-myo-inositol hexakisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="3"/>
        </location>
        <ligand>
            <name>1D-myo-inositol hexakisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="4"/>
        </location>
        <ligand>
            <name>1D-myo-inositol hexakisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>1D-myo-inositol hexakisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>1D-myo-inositol hexakisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>1D-myo-inositol hexakisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>1D-myo-inositol hexakisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>1D-myo-inositol hexakisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00075894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGS19097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PDB" id="5IJP"/>
        </source>
    </evidence>
    <sequence length="804" mass="91612" checksum="139C49D6A4CD3CE8" modified="2011-10-19" version="1">MKFGQQLRSSIIREYQWHYIDYDGLKADLKRASGPLVASSDPTKPPRREWTEDDESRFVSKLEAELDKVHAKQQVKAMEISRRIAVSEREVQDVVGRLQDRGPGQEGPSEEEFMLLEEDLSDIIADVHDLAKFVQVNYTGFYKIIKKHDKMTGWRLKPVFDTRLKAKPFYKENYDASVVRLSKLYDLVRTRGNPAKGDTAAGASQGSFIRHTTKYWVHPDNVTELKLIILKHLPVLVFNPSKEFETQDTAITSVYFDNPDTWELYEGRLKKNEGAEAIRLRWYGGMQTETIFVERKTHREDWTGEKSVKARFSLKEKNVNAYLRGELLPKAIFEKARKEGKKSAKAIDEDERLAREIQYSILKRGYKPVCRSFYHRTAFQLPADARVRISLDTELTMIREDNLDGVRRSGDNWRRMDIGIDYPFSQLPPGDIVRFPYAILEVKLQTQLGQEPPEWVRQLTSSHLVEAVPKFSKFIHGVATLFPTRIHLLPYWMPQMDVDIRKPPTHDFGIKRTEQSATTSISDDDDEEEEEDSDMEQEKTTPPREGETSAAAAAAAAGARNGRALPAGADIEDQTIDRPTAPGPGDGTYLYDSDDEDLSDSDRLAEARRVGPWAYYTTLASTKARAAGRTTLHVLKWLVPRPRSTPMPRNARLESLLGTGEIQTRRFKAPRGKRIHVPVRVEPKVYFAAERTFLGWLEYSIYISTIAVTLLNFGSRAKDETSSSSISVSLSHRKVSFIAAAAFTVLAILSLMYAVVVYLYRSQAIRERRVARYYDKWGPSALCFALLVAVGLNFGLEGRKRGVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCM6</accession>
    <name>G0SCM6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">calcium/calmodulin-dependent protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CTHT_0057770</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.17" evidence="2"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696097.1">
        <property type="nucleotide sequence ID" value="XM_006696034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCM6"/>
    <dbReference type="STRING" id="759272.G0SCM6"/>
    <dbReference type="GeneID" id="18259815"/>
    <dbReference type="KEGG" id="cthr:CTHT_0057770"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_0_1"/>
    <dbReference type="OMA" id="HDWFESR"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000449">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000278">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="7 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="23"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="381"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="381"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGS19152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="413" mass="46854" checksum="A0CD821445BF5130" modified="2011-10-19" version="1">MSFQSMLNRLHGQPESYDKKSKYKFGRTLGAGTYGMVREADSPYGRVAVKIILKRNVRGNEQMVLDELHLLQTLNHPHIVKFVDWFESRDKYYIVTQLATGGELFDRICERGKFTEKDASQTIKQILEAVDYLHKHNVVHRDLKPENLLYLTRDADSDLVLADFGIAKMLGHKDELLTTMAGSLGYAAPEVMMRQAHGKPVDMWSMGIITYVLLCGYSPFRSENLQDLIDECNACNVVFHERYWRDVSDDAKDFILKLLRPRPEDRWTSEQALRHPWLTGKSASDHNLLPEIRAYLARARLRRGIEMVKLANRIEALKAQEADPENSDIPQDATLAADQSRLNPTGAVGADGQPEGRRQLSRAIKSAIFREVVLAKVREMKQQEETQRKTEEAAAQAQAAAAAAEAAQARRIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCY0</accession>
    <name>G0SCY0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helix-turn-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0058760</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696196.1">
        <property type="nucleotide sequence ID" value="XM_006696133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCY0"/>
    <dbReference type="STRING" id="759272.G0SCY0"/>
    <dbReference type="GeneID" id="18259914"/>
    <dbReference type="KEGG" id="cthr:CTHT_0058760"/>
    <dbReference type="eggNOG" id="ENOG502SEWH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2063104_0_0_1"/>
    <dbReference type="OrthoDB" id="4085451at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054448">
        <property type="entry name" value="HTH_put_ascomycetes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22943">
        <property type="entry name" value="HTH_68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helix-turn-helix" evidence="1">
        <location>
            <begin position="54"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="100" mass="10611" checksum="39D70D64B29A71CA" modified="2011-10-19" version="1">MDASGIAQTLSAPQYPSSRANITLNVLEARRKLEAEAQAELDNLGKLTNKGRQFLDITTIKQALVLRDRGVATSDIESQLGLRPGVVAKLGPKGLVSPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G0SD77</accession>
    <name>G0SD77_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">mRNA 3'-end-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0059230</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CPSF4/YTH1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696242.1">
        <property type="nucleotide sequence ID" value="XM_006696179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SD77"/>
    <dbReference type="STRING" id="759272.G0SD77"/>
    <dbReference type="GeneID" id="18259961"/>
    <dbReference type="KEGG" id="cthr:CTHT_0059230"/>
    <dbReference type="eggNOG" id="KOG1040">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024513_1_0_1"/>
    <dbReference type="OMA" id="SLVCKHY"/>
    <dbReference type="OrthoDB" id="1914176at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000012">
        <property type="entry name" value="cleavage and polyadenylation specificity factor subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045348">
        <property type="entry name" value="CPSF4/Yth1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102:SF24">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 11 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="205"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="205"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="236"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU369008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS19297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="265" mass="29423" checksum="550AAC803E3749A9" modified="2011-10-19" version="1">MATTTSPPPTGPNPMAAHLLARTHPTYTFTFTPFLQKTYQHSLPADRPVCKAYQTGSCPLKSHCPERHTLLPSTANANNGKDPQTGTGGGGGGFGSLVCKHWLRALCKKGETCEFLHEYNLRKMPECNFFVRNGYCSNGDECLYLHIDPSSRVPPCPAYERGFCPAGPKCDKKHVKRKMCPYYLAGFCPEGKACKEGAHPKWVGDKELEKLMGKEEKKDNAGTEGQQQQGQVSGQQDEKEKEKEREAREREERERTERGEGEGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDG6</accession>
    <name>G0SDG6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0051710</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695512.1">
        <property type="nucleotide sequence ID" value="XM_006695449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDG6"/>
    <dbReference type="GeneID" id="18259209"/>
    <dbReference type="KEGG" id="cthr:CTHT_0051710"/>
    <dbReference type="HOGENOM" id="CLU_1272143_0_0_1"/>
    <dbReference type="OrthoDB" id="2426396at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39599:SF2">
        <property type="entry name" value="ANCHORED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G09650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39599">
        <property type="entry name" value="GPI-ANCHORED PROTEIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409488" evidence="1">
        <location>
            <begin position="19"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="217" mass="24315" checksum="E0BEBE60D59A3D1D" modified="2011-10-19" version="1">MHPPSMLLLLGATSVAQATNQNKPRPRNVMPTAIKKMPPDQGAKFYPHYVAFPDTDNDDSRIFLAARSRTWHNISSLNLDQISPLAPFAPHLLRDISPNPLRRSLQERQWACPSDTHSCDAIGYPNSCCWEGTTCMVVPDTGLGPVGCCPEGARRPKPIHNNPNHHFNLHNPHQHNYQHDHSARLSWSTVSTYLFTFFLFLSSLNDPLPTFQHHGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDJ3</accession>
    <name>G0SDJ3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit F</fullName>
            <shortName evidence="4">eIF3f</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0051990</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit F family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695539.1">
        <property type="nucleotide sequence ID" value="XM_006695476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDJ3"/>
    <dbReference type="STRING" id="759272.G0SDJ3"/>
    <dbReference type="GeneID" id="18259237"/>
    <dbReference type="KEGG" id="cthr:CTHT_0051990"/>
    <dbReference type="eggNOG" id="KOG2975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027018_0_0_1"/>
    <dbReference type="OMA" id="EYFVHFH"/>
    <dbReference type="OrthoDB" id="25498at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08064">
        <property type="entry name" value="MPN_eIF3f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000019">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03005">
        <property type="entry name" value="eIF3f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027531">
        <property type="entry name" value="eIF3f"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF6">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="31"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="313"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="374"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS18594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="384" mass="40742" checksum="FDF2E30A99A1BB3C" modified="2011-10-19" version="1">MAVEQEQFVHLARPLAPTAVGFAVGSAPLTVNIQPQAVFSIIDHAVRRDIRDTQSTRVIGALVGTRNEDGSEVEVRSTFAIPHTENEDQVEVDVEYQKNMLALTLRASPRETLLGWYTTSHELNSFSALIQNFFASPETGTFPHPAIHLTISTEPGAPIETKTYISAPVAVSPERAAESCLFVEVPHRILFSDAERAALGTIQAAANSDHRTAPVVSDIESLAQALESVSDMLERVSTYVSEVLDEERDGNHALGQYLMNALSLAPKVSETQIEQDFNNHIQDVLMVSYLANTIRTQIDLAQRLATAPLAGEKDLLGSEGKGDGGEGTSGSKQEGGRSGAGGSGGAGASSGGRGTKRAGGRTGGGGARSGGQQRESREPRENGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDN1</accession>
    <name>G0SDN1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">FACT complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CTHT_0052370</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="19 20 21" key="2">
        <citation type="journal article" date="2013" name="Nature" volume="499" first="111" last="114">
            <title>Structural basis of histone H2A-H2B recognition by the essential chaperone FACT.</title>
            <authorList>
                <person name="Hondele M."/>
                <person name="Stuwe T."/>
                <person name="Hassler M."/>
                <person name="Halbach F."/>
                <person name="Bowman A."/>
                <person name="Zhang E.T."/>
                <person name="Nijmeijer B."/>
                <person name="Kotthoff C."/>
                <person name="Rybin V."/>
                <person name="Amlacher S."/>
                <person name="Hurt E."/>
                <person name="Ladurner A.G."/>
            </authorList>
            <dbReference type="PubMed" id="23698368"/>
            <dbReference type="DOI" id="10.1038/nature12242"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 651-945 IN COMPLEX WITH CA(2+)</scope>
    </reference>
    <comment type="function">
        <text evidence="10 11">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the FACT complex.</text>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-16058507">
            <id>G0SDN1</id>
        </interactant>
        <interactant intactId="EBI-16058545">
            <id>G0SHK5</id>
            <label>CTHT_0070340</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>3</experiments>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M24 family. SPT16 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695577.1">
        <property type="nucleotide sequence ID" value="XM_006695514.1"/>
    </dbReference>
    <dbReference type="PDB" id="4KHA">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.35 A"/>
        <property type="chains" value="A=652-945"/>
    </dbReference>
    <dbReference type="PDB" id="4KHB">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.40 A"/>
        <property type="chains" value="A/C/E/G=521-647"/>
    </dbReference>
    <dbReference type="PDB" id="4KHO">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.00 A"/>
        <property type="chains" value="A/B=651-945"/>
    </dbReference>
    <dbReference type="PDBsum" id="4KHA"/>
    <dbReference type="PDBsum" id="4KHB"/>
    <dbReference type="PDBsum" id="4KHO"/>
    <dbReference type="AlphaFoldDB" id="G0SDN1"/>
    <dbReference type="SMR" id="G0SDN1"/>
    <dbReference type="DIP" id="DIP-60189N"/>
    <dbReference type="IntAct" id="G0SDN1">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0SDN1"/>
    <dbReference type="GeneID" id="18259275"/>
    <dbReference type="KEGG" id="cthr:CTHT_0052370"/>
    <dbReference type="eggNOG" id="KOG1189">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004627_1_0_1"/>
    <dbReference type="OMA" id="YHINTIP"/>
    <dbReference type="OrthoDB" id="10251642at2759"/>
    <dbReference type="EvolutionaryTrace" id="G0SDN1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01091">
        <property type="entry name" value="CDC68-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.150:FF:000002">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.210:FF:000001">
        <property type="entry name" value="FACT complex subunit spt16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000017">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000006">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000005">
        <property type="entry name" value="FACT complex subunit spt16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.210">
        <property type="entry name" value="FACT complex subunit Spt16p/Cdc68p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029148">
        <property type="entry name" value="FACT-SPT16_Nlobe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056595">
        <property type="entry name" value="Fact-SPT16_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048969">
        <property type="entry name" value="FACT_SPT16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013953">
        <property type="entry name" value="FACT_SPT16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040258">
        <property type="entry name" value="Spt16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033825">
        <property type="entry name" value="Spt16_M24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980">
        <property type="entry name" value="CDC68 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980:SF15">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14826">
        <property type="entry name" value="FACT-Spt16_Nlob"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24824">
        <property type="entry name" value="PH_SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08644">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21091">
        <property type="entry name" value="SPT16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01285">
        <property type="entry name" value="FACT-Spt16_Nlob"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01286">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="19 20 21" id="KW-0002">3D-structure</keyword>
    <keyword evidence="21" id="KW-0106">Calcium</keyword>
    <keyword evidence="2 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FACT complex subunit SPT16 N-terminal lobe" evidence="14">
        <location>
            <begin position="6"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="FACT complex subunit SPT16 middle" evidence="15">
        <location>
            <begin position="547"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="16">
        <location>
            <begin position="821"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="446"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="943"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="626"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="476"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="945"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1003"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="780"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="783"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGS18632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="19">
        <source>
            <dbReference type="PDB" id="4KHA"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PDB" id="4KHB"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="21">
        <source>
            <dbReference type="PDB" id="4KHO"/>
        </source>
    </evidence>
    <sequence length="1029" mass="117280" checksum="5F7DB60886762EB7" modified="2011-10-19" version="1">MADIKIDSKLFQERISHFISAWKADKRSGDALFGGVSSIVILMGKVDEEPEFYKNNAMHFWLLGYEFPTTLMLFTLDTLYIITTQKKAKYLDQIKGGRFPVEVLVRGKDNAENEKTFIKIADMIKAAGNKVGVLTKDTSKGPFIDEWKKIFAERCKGVEEVDIALALSAGAFSIKDETELRAMRTSSKACVALLTPYFLDEMSSILDQDKKISHASLADKVMNKLEDEKFWKTVELPNRGKLPSDFDPEQLDWILGPIVQSGGKFDLKWQTDSDDEPLHPGIIIAAMGLRYKSYCSQIARTFMVDPNKSQESNYRVLLAVHNLILKEIRDGVVVKDVYNKAYNLIKTKKPELEKHFLKNVGYGIGLESKDSTLILSAKNTRTLKDGMTLCIVTGFSDIPNPDPQGKKDKVYSLVLTDTIRVTTGEPVVFTGEAPSDMDATSFFFKDEEEAQPTPKKEKKDPRVGAVATRNITSTRLRSERNTAPDEDAEKRRREHQKELAAKKQKEGLLKYADATAGQNGVEVKKFKRFESYKRDNQLPPKVRDMGIVIDQKNNTIVLPIMGRPVPFHINTIKNASKSDEGEWSFLRINFLSPGQGVGRKDDQPFEDASAHFVRSLTFRSTDGDRYAEIANQISNLKREAVKREQEKKDLEDVVEQDKLIEIRNRRPAVLDNVYIRPALEGKRVPGKVEIHQNGIRYQSPLSTTQRVDVLFSNIRHLFFQPCQNEMIVIIHLHLKDPILFGKKKTKDVQFYREAIDIQFDETGNRKRKYRYGDEDEFEAEQEERRRKAELDRLFKSFAEKIAEAGRNEGIEVDMPIRDLGFNGVPNRSNVVIYPTTECLIQITEPPFLVITLEDVEWAHLERVQFGLKNFDLVFVFKDFTRPVVHINTIPVESLEDVKEFLDSSDIPFSEGPLNLNWSVIMKTVTANPHQFFLDGGWGFLQNDSDASDASEEEEDEDSAFEISESELEAASESSEEDSDYEDASEEESDAPPSEDDEGESWDELERKARKRDRESGLDDDDRGGKKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDP7</accession>
    <name>G0SDP7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative chaperone protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0052530</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695593.1">
        <property type="nucleotide sequence ID" value="XM_006695530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDP7"/>
    <dbReference type="STRING" id="759272.G0SDP7"/>
    <dbReference type="GeneID" id="18259291"/>
    <dbReference type="KEGG" id="cthr:CTHT_0052530"/>
    <dbReference type="eggNOG" id="KOG0712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043818_0_0_1"/>
    <dbReference type="OMA" id="FSAWGRY"/>
    <dbReference type="OrthoDB" id="436519at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051948">
        <property type="entry name" value="Hsp70_co-chaperone_J-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409151" evidence="3">
        <location>
            <begin position="20"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="4">
        <location>
            <begin position="76"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS18648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="376" mass="42407" checksum="3AEB3D907F6E2DEC" modified="2011-10-19" version="1">MSNLLSLLGWTFLPNVVTGWVQSLYYSLTIRAGDPRPVPGTPRWAEHRRCIQIVVVALYLLYTIYEADYDLQQAGTFYTDLGIPNNATEREIKIRFRRLAALYHPDKVAHKTPDANAYFVHLKTAADTLTDPAKRFAYDRFGPDIVNWQRCVTIRDFMARGAQALIPYYGMTAICMYGLSLFGFLEWGRYERWLVLASVLTFEAYCITRPNMPFVLEKIINPLVTALSRLVGDATSSPAAFIRAPYLPFQAIALARKVSVTMFIAFSQIGPLLTADTSSGRVVVRQNAADEEVLLRQALDRLDAAVRKVDSDASRLLETEMSPFNGDEEVKKYMGAKIKEWLVQNTIRSDPMVRDALGRSFMKRRANVPAGARGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDQ0</accession>
    <name>G0SDQ0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0052570</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695596.1">
        <property type="nucleotide sequence ID" value="XM_006695533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDQ0"/>
    <dbReference type="GeneID" id="18259295"/>
    <dbReference type="KEGG" id="cthr:CTHT_0052570"/>
    <dbReference type="HOGENOM" id="CLU_679722_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS18651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="405" mass="44405" checksum="F3477114ECA5C436" modified="2011-10-19" version="1">MSLTDQPLSQLIYPPFSFNTPPNPFKTLLPSAQTAGGDGAIGGGASYYLGPPTPAPDAQPSGGSFGEQYPWLWMLLPIGLIFCIGATVTWFQNRALRRRHAERVAELAALRRQRLALLGGLPDRMSAEEQGDGERDVEAEAGVGAEASRHQGVQGQQERQGAARPPFDWTSFILQQQQQMAEEQRRREEGLNTYDDPPPPYEKELPSYPPLAVLAPQRGFVAEEVTGTPGPPPYNASPRPSSPSGSAQPVRVPPPVDHGRHQQAASASSQGHDDHHNEWPRVTERHSPSPESNIDNDPVRISPARNLRRSHSQTDLRGSSSICERQQDVGAAQPRRDSAKELSDSTNEWEEMIRTTNKSSSRRNSNSFGSVYSLDWLRTGEDAGDSSGQGKDTDRNKDEKGQSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDS4</accession>
    <name>G0SDS4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar-sorting protein SNF7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Vacuolar protein-sorting-associated protein 32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0052810</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695620.1">
        <property type="nucleotide sequence ID" value="XM_006695557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDS4"/>
    <dbReference type="STRING" id="759272.G0SDS4"/>
    <dbReference type="GeneID" id="18259319"/>
    <dbReference type="KEGG" id="cthr:CTHT_0052810"/>
    <dbReference type="eggNOG" id="KOG1656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071097_1_0_1"/>
    <dbReference type="OMA" id="MKQIHGG"/>
    <dbReference type="OrthoDB" id="5592979at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF10">
        <property type="entry name" value="GH13992P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS18675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="220" mass="24970" checksum="C5EAB6BA47DFD3D5" modified="2011-10-19" version="1">MSGIWSWFGGGSQKRKDTPKNVILDLRTQLDMLQKREQHLMRQIEEQEQIARKNVNTNKAAAKAALRRKKIHEHNLEQTLNHIATIEQQMNAIETANINQETFLAMQRASEAMKSIHGKLTPEKVEVTMDILQEHNRFNEEISQAMSSIAIGPQVDEGELEEELEALQQQDLEEKMLKTGTVPAQKLPEVANGELKGKAPAVEEDDEEAELRKLQAEMAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDX9</accession>
    <name>G0SDX9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0053380</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695675.1">
        <property type="nucleotide sequence ID" value="XM_006695612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDX9"/>
    <dbReference type="STRING" id="759272.G0SDX9"/>
    <dbReference type="GeneID" id="18259376"/>
    <dbReference type="KEGG" id="cthr:CTHT_0053380"/>
    <dbReference type="eggNOG" id="KOG0682">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_33_0_1"/>
    <dbReference type="OMA" id="NVMMKNM"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000003">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002229">
        <property type="entry name" value="RhesusRHD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF10">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00342">
        <property type="entry name" value="RHESUSRHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="9">
        <location>
            <begin position="42"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS18730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="509" mass="54503" checksum="FD0224F6A0001D32" modified="2011-10-19" version="1">MDGVDLDHLPYSPLVPYNGTGSLGGDPLEENLNIWYESGDIAFIIFSTALVLLMIPGVGLFYSGLARRKSALSLIWLSVMSAAVTNFQWFFWGYSLTFSRSGSRFIGDLSHFAFRDLLAAPSVGSPRVPDLLFAVYQGMFSALTVALVTGAVAERGRMLPCVVFMFIWSTVVYDAIACWTWNPNGWSNRMGGLDFAGGTPVHIASGAAALAYSMMLGKRRGHGTHELNYRPHNVTHIVVGTVFLWVGWFGFNAGSALAANMRAIMAAVVTNLAACVGGVTWCLLDYRLERKWSTVGFCSGVVAGLVAITPGSGFVPAWAAVPSGVLGAAFANYATKLKFLLGVDDALDIFAVHGVGGLVGNLCTAFFADKSVARLDGMSNPIGGGWLNQHWIQLPIQLADSCAGGAYSFVMTCLILLLMNLIPGLHLRVEEAAEIVGVDDAEIGEFAYDFVELTREVVVDVDATVAGSSNRGSGGFGYGESASMFSNGEREQAGQYFKESRMYQVGIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0SE05</accession>
    <name>G0SE05_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative cap-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0061970</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696513.1">
        <property type="nucleotide sequence ID" value="XM_006696450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SE05"/>
    <dbReference type="STRING" id="759272.G0SE05"/>
    <dbReference type="GeneID" id="18260235"/>
    <dbReference type="KEGG" id="cthr:CTHT_0061970"/>
    <dbReference type="eggNOG" id="KOG1104">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013816_0_0_1"/>
    <dbReference type="OMA" id="CAAEGLM"/>
    <dbReference type="OrthoDB" id="10252707at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000079">
        <property type="entry name" value="Related to cap binding protein 80 (Cbp80)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000035">
        <property type="entry name" value="snRNA cap binding complex subunit (Gcr3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027159">
        <property type="entry name" value="CBP80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015172">
        <property type="entry name" value="MIF4G-like_typ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015174">
        <property type="entry name" value="MIF4G-like_typ-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412">
        <property type="entry name" value="CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412:SF2">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09088">
        <property type="entry name" value="MIF4G_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09090">
        <property type="entry name" value="MIF4G_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G-like type 1" evidence="2">
        <location>
            <begin position="329"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G-like type 2" evidence="3">
        <location>
            <begin position="536"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="743"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="792"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="752"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="792"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="825"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS18182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="841" mass="95315" checksum="F78892099FBBD6C6" modified="2011-10-19" version="1">MADYDRRGGGSSYNSRKRRYRDDDEYERRAPPRRRYDNVPPPHVRVRKQLIAIAENPMRPWHEEVYSIATLFTDNWDDELLRSNFVDLALQLAVEQPLKTPFVAAVVIVANAARPEIVDMLLAKLAKLVEEKIAEGEWRQVKLYLKLLACLQGCLEGEGIFPLLEELFNRAVDLQTASSEDTIGTEIVKIILLTLPYVMVAAPGKWNQKAADLMEKTEVIASEPHTSQALVEPWHPESSDETAPQSQSLIGLLQAQLQNEANNGWALPYLPRPWEFPPSNSEMQTKLQNAQKHALPAIQIPETVIAGPRPLFPEVYFSVYANQEVQSVPPTTNAAASLIRDALLDTINQLDFNRNVTARHLIDLDCFFSQRTFTARATPFDKLREIEPPKSTWKPEDVAVDAVFSQIFTLPNPEHKLVYYHSVLTEACKLAPAAIAPSLGRAIRYLYRNAPRMDWELAYRFMDWFAHHLSNFGFTWKWTEWVDDVELPDVHPRKAFILGAIDKEIRLSFAQRIKNTLPDPYKVLIPPEKEKDAPDFKFANDETPFAPEGREIASLLKRKAADEEIETYIQRIQSQAVDRDMDALVASTDVFVTCVLHIGNKSLSHVLAAIERTKDRLADAGAASDAARAQIITATMAYWSAHPGVAITIIEKLLNYSILTPAAVLEWVLRGRVAETRGRVLGTAYMYELVANTVNKVTSRVRGLAFKVPTTPEEEEEDAKTRETEVARMRALFTEIEEALAPWASSSAREEQMEEDGKNEEDERMVRRWADRWLRVFRRRAAIEETWLVEAAKERERKKAKAAEEKAAEEAKKEQEEKEDGKKPANGVAENGEGEGMNVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0SE27</accession>
    <name>G0SE27_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0062190</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696535.1">
        <property type="nucleotide sequence ID" value="XM_006696472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SE27"/>
    <dbReference type="STRING" id="759272.G0SE27"/>
    <dbReference type="GeneID" id="18260257"/>
    <dbReference type="KEGG" id="cthr:CTHT_0062190"/>
    <dbReference type="eggNOG" id="ENOG502S146">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050438_7_1_1"/>
    <dbReference type="OMA" id="RAKEECQ"/>
    <dbReference type="OrthoDB" id="6159137at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="72"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="138"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="184"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS18204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="344" mass="40476" checksum="C9E3FC942B03EFE1" modified="2011-10-19" version="1">MATTSMDYENANGDRYEDDGHRYDRDRSASPRRDDSRDERRRSVSPNGNDRAPTKSENAPKEEDNSAVNPGSNLFVTGIHPRLEESEITRLFEKYGEVEKCQIMRDPHTGESRGFGFVKMMTSEQAEAAMEGLKGEIIEGRTLNIEKARRSRPRTPTPGKYFGPPKRDPRRYDDRRRGGYGGYGRDDSYRGGRGYGRDDRGYDRGYDRGYDRGYDRSYGRDYRDDRGYDRRDYRDDRYDRIDRYRDDRDRYGRDDRDRYGGRGGPDDRRGPSYDRDRYERPMDRDRDSRPRDAPPSGTGYDSAPRGDVRDREPYGRTRSPSHSRYSPRSRYSPRYSPPPRSRYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0SE29</accession>
    <name>G0SE29_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CSI2 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0062210</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696537.1">
        <property type="nucleotide sequence ID" value="XM_006696474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SE29"/>
    <dbReference type="GeneID" id="18260259"/>
    <dbReference type="KEGG" id="cthr:CTHT_0062210"/>
    <dbReference type="eggNOG" id="ENOG502S625">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037244_1_0_1"/>
    <dbReference type="OMA" id="ANAPYMQ"/>
    <dbReference type="OrthoDB" id="4065319at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051009">
        <property type="entry name" value="PRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36089">
        <property type="entry name" value="CHITIN SYNTHASE 3 COMPLEX PROTEIN CSI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36089:SF1">
        <property type="entry name" value="CHITIN SYNTHASE 3 COMPLEX PROTEIN CSI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409157" description="CSI2 protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="393"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS18206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="417" mass="42919" checksum="BC9789EBDB9EB090" modified="2011-10-19" version="1">MTSPPLSLKRALLLSAFFALRVLAQDDDGKSQTSVAAAPTTSQRQNNPPQATTSANNDNNNNPPTTTIVQPPPVRTTTTPAPPAQTSETKDEPETSTTSERLNLPALTTSTSSTTYSRLTDMPTLSRTVNTEIPTYPPPTIPPTKNAPFMNHSTLPDGTVFIAVGAILGGFGLAVLAWRAMVAFMLRRSIKEAARAQYAANNGHGKGMDKNAASFPAPPAQFYKYLERESSHSLAGGPGAGSSSNGAGIGVRRTNRGATPSATPSQTNLFFSPTAAGSSAAGVTANRDSRFLPSGFYASPASPIANQFGSAGGGGGGHHSGNSISMSTLRPSSRGRAGVSAVSPPDSPDVGPRVVSRNYSTSSLNLNRPPSPGGRAPSAYLDDLLDEQPGMFPPAGGVAGPSSAGQRPGGGSQRSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0SE32</accession>
    <name>G0SE32_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C-8 sterol isomerase</fullName>
            <ecNumber evidence="8">5.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Delta-8--delta-7 sterol isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0062240</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ERG2 family.</text>
    </comment>
    <dbReference type="EC" id="5.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696540.1">
        <property type="nucleotide sequence ID" value="XM_006696477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SE32"/>
    <dbReference type="STRING" id="759272.G0SE32"/>
    <dbReference type="GeneID" id="18260262"/>
    <dbReference type="KEGG" id="cthr:CTHT_0062240"/>
    <dbReference type="eggNOG" id="KOG4143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085469_0_0_1"/>
    <dbReference type="OMA" id="AMYVIHA"/>
    <dbReference type="OrthoDB" id="347124at2759"/>
    <dbReference type="UniPathway" id="UPA00768"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006716">
        <property type="entry name" value="ERG2_sigma1_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868">
        <property type="entry name" value="SIGMA 1-TYPE OPIOID RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868:SF1">
        <property type="entry name" value="SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04622">
        <property type="entry name" value="ERG2_Sigma1R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS18209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="242" mass="27025" checksum="416A12546698BB6F" modified="2011-10-19" version="1">MAPSKSKQAASSGCNCKKSKCCAGGVTGWLKIFAILLGVLAPIVYYLEQNLNRFYIFDLDHLHDLSKRSIAAHGNDTRAIVKYIVDELTSKVELKPYINTDEEWVFNNAGGAMGAMYIIHASITEYLIIFGTAIGTEGHTGRHTADDYFHILTGTQVAYTPGKYEAEVYPPGSMHWLPRGEVQQYKMPEGCFALEYARGWIPPMLFFGFADTFSSTLDFPTLWRTVVITAREMIANLLKGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0SE40</accession>
    <name>G0SE40_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative cytochrome P450 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0062330</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696548.1">
        <property type="nucleotide sequence ID" value="XM_006696485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SE40"/>
    <dbReference type="STRING" id="759272.G0SE40"/>
    <dbReference type="GeneID" id="18260271"/>
    <dbReference type="KEGG" id="cthr:CTHT_0062330"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_25_2_1"/>
    <dbReference type="OMA" id="ICNARQS"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS18217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="426" mass="47787" checksum="B2C56916F2CD7BCF" modified="2011-10-19" version="1">MRWALNIIGYVGFGLRLIWPGQELPSDLDPNAGQIRQIVSIMVLPTLALKILPFKWAREAYEGKINFLQYMNEFLHDKIEEAKRGGPQKEGMDIMGQLVQSKYGRNASPASESKDGVPNILNDSEIIGNAFIMIVAGHETTANTLHFALLELANNPGTQRRMQRDIDNLFNGADPSTWDYERSINALMASYTGAVVNETLRMMPPVTGIPKVVNPECDQRITINGREHVLPAGVSCALQIVCAQRNPRWWPTRPSERTGKPNDMDDFLPERWYRSRDELRGAKREGTVVDDVAVPEDKTDYGGFQGSDTSAALYRPVRGSYAPFSDGPRSCLGRRIAMVEMNAVLAVIFQKYSIELAVDDWASDEEVAKMSPAERRAVYARAQERSRQLLREADSVLTLKLHGGRHVPVRFVKRGCERFVADPELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0SE61</accession>
    <name>G0SE61_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydrolase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0062560</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696569.1">
        <property type="nucleotide sequence ID" value="XM_006696506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SE61"/>
    <dbReference type="STRING" id="759272.G0SE61"/>
    <dbReference type="GeneID" id="18260294"/>
    <dbReference type="KEGG" id="cthr:CTHT_0062560"/>
    <dbReference type="eggNOG" id="KOG0806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030130_1_0_1"/>
    <dbReference type="OMA" id="MQSKPYA"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050152">
        <property type="term" value="F:omega-amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006528">
        <property type="term" value="P:asparagine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07572">
        <property type="entry name" value="nit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000002">
        <property type="entry name" value="Nitrilase family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045254">
        <property type="entry name" value="Nit1/2_C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF30">
        <property type="entry name" value="OMEGA-AMIDASE NIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="3">
        <location>
            <begin position="14"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS18238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="305" mass="33063" checksum="26D9AE746E6941F6" modified="2011-10-19" version="1">MATSSYPLLLKQPVKLACVQLATGADKTANLAHAAEKVREAASAGAKIVVLPECFNSPYGCDYFPSYAEQLLPSPPSPEQSPSFHALSAMARDNGVYLIGGSIPEIEVSADNKKTYYNTSLTFSPAGELLATHRKVHLFDISIPGGITFRESDVLSPGNKLTVVDLPEYGRVAIAICYDVRFPELATIAARKGCFALIYPGAFNLTTGPLHWRLLGQARAVDNQVYVALCSPARDMSASYNAWGHSLVVDPMAKVLVEAGEGEEIVSAELNGEEIEKARRGIPLREQRRFDVYPDISQGYELKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0SE96</accession>
    <name>G0SE96_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC1 atypical kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0062970</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696604.1">
        <property type="nucleotide sequence ID" value="XM_006696541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SE96"/>
    <dbReference type="STRING" id="759272.G0SE96"/>
    <dbReference type="GeneID" id="18260335"/>
    <dbReference type="KEGG" id="cthr:CTHT_0062970"/>
    <dbReference type="eggNOG" id="KOG1235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006533_2_5_1"/>
    <dbReference type="OMA" id="KVQYPWI"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF19">
        <property type="entry name" value="AARF DOMAIN-CONTAINING PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="4">
        <location>
            <begin position="187"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS18273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="601" mass="67876" checksum="180B5B23EDB41444" modified="2011-10-19" version="1">MLKRTISSARFLNTTALLGWTCARCRSQLLPPLSRPIQTLIRARAQRAAARRHASTTTPSATIPKMGRSKPRSRRTAIVLLASAGGGILAMLAAAGEDVKNGYEALERTGRVAAALVLCINDTLNEREKIQDDEEKERLLSACHKRCALRTLKVLEQNGGIFIKLGQHLSAMNYLLPPEWTTTFIPLQDKCPVSSFESIEEMFRTDTGGELWDYFSEFSPEPIGAASLAQVHLATIKETGQKVAVKVQHPSLEQFSKLDMSLTSFTFSTLKRFFPEYDLEWLSSEIEVSLPKELDFRCEAENARRTKEYFSRIPELPLVIPDVIWAQKRILVMKCETGKRLDDLAYMDAEGIDRDEVSATLARIFNEMIFGDGAPLHCDPHGGNIAIRKNASRGLGRPNFDLILYDHGLYRDIPTDLRRSYAKMWLAIIDGDMERTKKYVGEVAGVGEDKFQLFASAITGRDWSVVSSSIMKPKDPSEQKSMSTALQEGLLVDLVQMLGQVPRIILLILKTNDLTRSLDENLQTRQGPVRQFLILARYCMRTVFREQLDEIRAHGSLCWPPNAIRVLAAWLGFLRVEMQLRAFEMWVGLRRLLGLRRIEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEE4</accession>
    <name>G0SEE4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1761-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0063450</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696652.1">
        <property type="nucleotide sequence ID" value="XM_006696589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEE4"/>
    <dbReference type="GeneID" id="18260383"/>
    <dbReference type="KEGG" id="cthr:CTHT_0063450"/>
    <dbReference type="eggNOG" id="ENOG502S2WW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1034398_0_0_1"/>
    <dbReference type="OrthoDB" id="2344991at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013879">
        <property type="entry name" value="DUF1761"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40638">
        <property type="entry name" value="UPF0591 MEMBRANE PROTEIN C15E1.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40638:SF1">
        <property type="entry name" value="UPF0591 MEMBRANE PROTEIN C15E1.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08570">
        <property type="entry name" value="DUF1761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="29175" checksum="ED184B6275E5567F" modified="2011-10-19" version="1">MFTTATKFSLSRIRILQPREPHFGREACSGENERLGVALNGKPTVENHDALFWGEIRTWEITRTSCLTATTITINLALNERVTELLEVDLGVSSSIVQLANIMSLHYLPAVKPSAIALGTFFNQSVELAVLSPLFGQTYQRAKAANTKEEFLRSREATGAAVAWTTSLVGSALQSYGVGALINATGTLSYRGAAYLGGLIFMATSAPTFFGQLFVEKRAWETVGVSVIAKLFETIGLSLVLTWWGTRTNPLEHSGAGGTPLSRSPFRND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEL6</accession>
    <name>G0SEL6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ricin B lectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0064180</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696724.1">
        <property type="nucleotide sequence ID" value="XM_006696661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEL6"/>
    <dbReference type="GeneID" id="18260456"/>
    <dbReference type="KEGG" id="cthr:CTHT_0064180"/>
    <dbReference type="eggNOG" id="ENOG502SH6C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103467_0_0_1"/>
    <dbReference type="OMA" id="FDRKCAA"/>
    <dbReference type="OrthoDB" id="4426724at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409173" description="Ricin B lectin" evidence="1">
        <location>
            <begin position="20"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="19913" checksum="61E22D42BFBD4CEE" modified="2011-10-19" version="1">MHLPTLLAAALAFTAPTSAWLTYSLQRVSNPTPDQQDAYNRITAAMDKAVARYNRLAPRANKYITVQYVPSVQTADGNINGNIRFGSNRAYMNERTALHEISHTLGVGTHASFDRKCAAQDWPNALRLLRSWDGQNAKINCGGGHFWPYGLNYDNEFSETNADRHCLIVDAMIQDGLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEP0</accession>
    <name>G0SEP0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyrroloquinoline quinone-dependent pyranose dehydrogenase beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0064430</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696748.1">
        <property type="nucleotide sequence ID" value="XM_006696685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEP0"/>
    <dbReference type="GeneID" id="18260481"/>
    <dbReference type="KEGG" id="cthr:CTHT_0064430"/>
    <dbReference type="eggNOG" id="ENOG502QPZ1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039534_1_1_1"/>
    <dbReference type="OMA" id="NMANNDQ"/>
    <dbReference type="OrthoDB" id="507128at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054539">
        <property type="entry name" value="Beta-prop_PDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH_b-prop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22807">
        <property type="entry name" value="TrAA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="Soluble quinoprotein glucose dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409511" description="Pyrroloquinoline quinone-dependent pyranose dehydrogenase beta-propeller domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroloquinoline quinone-dependent pyranose dehydrogenase beta-propeller" evidence="2">
        <location>
            <begin position="36"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS18417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="467" mass="51012" checksum="AF1ADB94DBD8917C" modified="2011-10-19" version="1">MKTRLALSLLPALASVAAETSCPTILIPNTWYPPITGPGWQGQVVAAGLTKPRSLAFDSTGALLVVESGKGISRHQFTDLGGTCLMPNHSHMLVELPRLNHGLALSASGDTIYASTPDSVLSWPYDARRGRVTGRSRIIIANMSNSDLVTRTLLMSRSRPNILIVSRGGPEDNIALAEKVENGFNQIKAFDLDELKDRGTDATYDFVKDGTVLGWGLRNSVGVGEHPLTGGIWAVENSVDRVTRNGVAVHEYNPGDELNFLGYLNGTGTGKNFGYPNCFAVWYKDEIPENEGLDIGMQFAERETEELTDETCAEKYEPPRLTFPAHNSPMDIKFEGDGSAAYVSFRGSFEGGKGYGYEIVRVLFDTTTGEPVLPANSGEVISDIRPIFNLDLSKCPENCFRPVGMAWDSNGRLWFASDSTGEIYVLYKLPGRDRQFIVPEGYYGKDSASGKGHVELQLWVESPQELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0SER2</accession>
    <name>G0SER2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative actin binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0059400</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS17928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696259.1">
        <property type="nucleotide sequence ID" value="XM_006696196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SER2"/>
    <dbReference type="STRING" id="759272.G0SER2"/>
    <dbReference type="GeneID" id="18259978"/>
    <dbReference type="KEGG" id="cthr:CTHT_0059400"/>
    <dbReference type="eggNOG" id="KOG3655">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013085_2_0_1"/>
    <dbReference type="OMA" id="FKEPRGA"/>
    <dbReference type="OrthoDB" id="5971719at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11281">
        <property type="entry name" value="ADF_drebrin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11962">
        <property type="entry name" value="SH3_Abp1_fungi_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11961">
        <property type="entry name" value="SH3_Abp1_fungi_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000242">
        <property type="entry name" value="Actin binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000273">
        <property type="entry name" value="Actin binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000045">
        <property type="entry name" value="Actin binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035719">
        <property type="entry name" value="Abp1_fungi_SH3_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035718">
        <property type="entry name" value="Abp1_fungi_SH3_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF25">
        <property type="entry name" value="DREBRIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="ADF-H" evidence="5">
        <location>
            <begin position="5"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="637"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="731"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="201"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="332"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="622"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="701"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="221"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="449"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="493"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="710"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS17928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="789" mass="83734" checksum="BD94719C754BD5A3" modified="2011-10-19" version="1">MASLNCSINGPSIRSSYQAVINGPAVSSTSPTAARWALFTVQAPLVSAFQNTVAKESILKVESTGDGELSELVEEFNEGRIQFAFVKVKDPNTGLPKHVLIAWCGGGVPERTKGYFTSHAAAVTKLLHGYHVQITARSETDLLPEDIIQKVADASGAKYSVASSAPAHSPAPAAVPPPVAKKPVFTPTTSVTTSSFNLAVRSRRRDDDDDGWGDAPPVTRTELEKVEPAYKPTKVDIAELRKNKDDSRSSEPSRDDRPSDIIKGGYQPVGKVDIAALRAQAKQEDRPTPVKGSYEPVGKVDIAAIRARAQQKEDEPAPLKSVAERSAAFTQAERLTELPKPKVAKKFGSTPFTGTKAPTPIGMGFGAPSVPPPPTVGSASRTFADQGGKTPAQLWAERKAKQGGATPSAVSPPPAATTITAQKSGTEWKSGYTGRTWAPVQTTNFGRGGVEKQKTGGTERSEPEPEPQQPVLTGGSVSALREKFKDAAPLGTTPRSPSSVATRSEDEPIPPPPPMGSRPVGGVALPGLPSRPTAANQEEEKKEEEPPAVPSRNYEEREPSPVRVAMPVPRSAVPEIEPPAERLPPRPIPAPEEVPKEEELPVDQEIQNPRTTAAVAATVASEALSRSASSGADTAGRSGRKALIQYDYDKAEDNEIDLREGEYVTNIEMVDDDWWMGTNSKGETGLFPSNYVELVNDDETGAAEASTAAPPSPAPPAATQPPPAPAVPAASTGPTATALFDYEAAEDNELSFPEGAKITNLEFPDEDWWFGHYNGASGLFPANYVQLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G0SER5</accession>
    <name>G0SER5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dynamin GTPase</fullName>
            <ecNumber evidence="2">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0059440</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="2"/>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS17931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696262.1">
        <property type="nucleotide sequence ID" value="XM_006696199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SER5"/>
    <dbReference type="STRING" id="759272.G0SER5"/>
    <dbReference type="GeneID" id="18259982"/>
    <dbReference type="KEGG" id="cthr:CTHT_0059440"/>
    <dbReference type="eggNOG" id="KOG0446">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008964_5_0_1"/>
    <dbReference type="OMA" id="KICHNCG"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1240:FF:000002">
        <property type="entry name" value="Dynamin-1-like protein isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000383">
        <property type="entry name" value="Dynamin-like gtpase dnm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF235">
        <property type="entry name" value="DYNAMIN-RELATED PROTEIN DNM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="14">
        <location>
            <begin position="27"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="13">
        <location>
            <begin position="701"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="524"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="588"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="524"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="594"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS17931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="788" mass="87686" checksum="F042F1412A8D2560" modified="2011-10-19" version="1">MAALGDDLLRTVNKLQDLVFNTIGNDSLDLPQIVVVGSQSAGKSSVLENIVGRDFLPRGAGIVTRRPLILQLINVPKDDAEDDPTPSYGVPGQAARNEWAEFHHIPNRRFTNFEDVKREIENETARVAGTNKGINRQPINLKIFSPHVPIGDQPTDIEKQTRNLISEYIAKPNSIILAVSPANVDIVNSEALKLARHVDPLGRRTIGVLTKVDLMDHGTNALDILTGRVYPLKLGWIGVVNRSQQDIQGNKPMSEALKAEAEFFRHHPAYRNIANRCGTQFLAKTLNQTLMAHIRDRLPDIKARLNTLMGQTQQELASYGDMHFSGKEHRGSLILQLMTRFATSFISSIDGTSTEISTKELCGGARIYYIFNSVFGSSLESIDPTQNLSAADIRTAIRNSTGPRPSLFVPEMAFDLLVKPQIKLLEPPSQRCVELVYEELIKICHTCGSTELSRFPRLQAKLIEVVSDLLRERLGPASAYVESLIAIQRAYINTNHPNFVGAAAAMSQIVSQRQERERKRLIQEERERRERRRMKELGANGTETPANEEDDNASVDRPDTVVIRKAPGKASRSLSPAVRDVGTPGGISAALNGARSQSPSRFNGQSLGNAKDSFLNYFFGKDGAATTPAPLPNANIGRHVSQSVEPTFSQSFRRPEEKGTLRSPIRSMRADDNLDYTQGAKANDPANSDELAMTEREAMETELIRALITSYFNIVREMIADQVPKAIMHLLVNYCKETVQNRLVSELYKESLFEELLYEDDAVKKEREKCEKLLQTYREAAKIIGEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEZ8</accession>
    <name>G0SEZ8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="13">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0060270</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 13">
            <text>6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="13"/>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696345.1">
        <property type="nucleotide sequence ID" value="XM_006696282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEZ8"/>
    <dbReference type="STRING" id="759272.G0SEZ8"/>
    <dbReference type="GeneID" id="18260065"/>
    <dbReference type="KEGG" id="cthr:CTHT_0060270"/>
    <dbReference type="eggNOG" id="KOG2653">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024540_4_2_1"/>
    <dbReference type="OMA" id="CVTHVGP"/>
    <dbReference type="OrthoDB" id="434986at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000002">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.320:FF:000002">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000007">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006113">
        <property type="entry name" value="6PGDH_Gnd/GntZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006184">
        <property type="entry name" value="6PGdom_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00873">
        <property type="entry name" value="gnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006765">
        <property type="entry name" value="PRK09287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000109">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00461">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="5 13" id="KW-0521">NADP</keyword>
    <keyword evidence="6 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 13" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="217"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="71"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="113"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="11">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="11">
        <location>
            <begin position="167"/>
            <end position="169"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="11">
        <location>
            <begin position="224"/>
            <end position="225"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="11">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="11">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="11">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS18014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="528" mass="57802" checksum="38334CED00C22923" modified="2011-10-19" version="1">MSGAVARLAQVGGALRAAASSLIKSEKDADNVPSADIGLIGLAVIRAYTARRGQNLILNMADHGFTVCAFNRTVSKVDAFLANEAKGKSIVGAHSVEEFVSKLKSPRRIMLLVQAGKPVDDWIETLIPLLSPGDIIIDGGNSHFPDTNRRVKYLASKGLRFVGSGVSGGEEGARHGPSLMPGGNEEAWPYIKDIFQAIAAKSEGEACCEWVGDEGAGHYVKMVHNGIEYGDMQLICEAYDLMKRGLGMSNKEIGDVFAKWNTGVLDSFLIEITRDIMYYNDDDGEALVEKILDKAGQKGTGKWTSVNALDLGMPVTLIAEAVLARCLSAIKDERVKASTRLEFVGRATTFEGNKEQFLEDLEQALYASKIISYAQGFMLMQEAAKEYNWKLNKPSIALMWRGGCIIRSVFLKEISAAYNRNPDLENLLFDDFFNKAIHKAQPGWRDVVAKAALLGIPTPAFSTALAWFDGYRTKDLPANLLQAQRDYFGAHTFRIKPEKANEKYPADKDIHVNWTGRGGNVSASTYNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0SF47</accession>
    <name>G0SF47_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear movement protein nudC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0060780</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for nuclear movement. May interact between microtubules and nuclei and/or may be involved in the generation of force used to move nuclei during interphase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696394.1">
        <property type="nucleotide sequence ID" value="XM_006696331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SF47"/>
    <dbReference type="STRING" id="759272.G0SF47"/>
    <dbReference type="GeneID" id="18260116"/>
    <dbReference type="KEGG" id="cthr:CTHT_0060780"/>
    <dbReference type="eggNOG" id="KOG2265">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047332_2_0_1"/>
    <dbReference type="OMA" id="RQKEMGG"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06467">
        <property type="entry name" value="p23_NUDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000001">
        <property type="entry name" value="Nuclear migration protein nudC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037898">
        <property type="entry name" value="NudC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356:SF3">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356">
        <property type="entry name" value="NUCLEAR MOVEMENT PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="6">
        <location>
            <begin position="45"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00059400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00068398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS18063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="212" mass="24198" checksum="979894B9EC840084" modified="2011-10-19" version="1">MSAAEESSQQTLGKRRSYKEAFGMDPKEPTPEEEAAAREKERQEQEALPYKWTQTIGDLDVSIPVPGNIKGRDVVVELKRNYISAGIKGQEPILKGDLPHAIRVDESTWTLTSSAKGDQKFIEIHLDKVNKMEWWAHVVTEAPKIDVTKIVPETSKLSDLDGETRSMVEKMMYDQRQKELGLPTSDEQKKMEILKKFQEQHPEMDFSKAKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G0SF62</accession>
    <name>G0SF62_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0060930</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696409.1">
        <property type="nucleotide sequence ID" value="XM_006696346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SF62"/>
    <dbReference type="GeneID" id="18260131"/>
    <dbReference type="KEGG" id="cthr:CTHT_0060930"/>
    <dbReference type="eggNOG" id="ENOG502SB54">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065618_0_1_1"/>
    <dbReference type="OMA" id="TWDVPSK"/>
    <dbReference type="OrthoDB" id="5589325at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052982">
        <property type="entry name" value="SRP1/TIP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633:SF1">
        <property type="entry name" value="GPI ANCHORED SERINE-THREONINE RICH PROTEIN (AFU_ORTHOLOGUE AFUA_1G03630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409518" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="24"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS18078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="208" mass="21594" checksum="9FFBCA1063BEFE08" modified="2011-10-19" version="1">MKASVSALLAFAAAVLGKPVLLNSGYAIEEGVPFTFKWSGAEGPVTLTLMTGDPSNLKPVYTIVSGVTDSQFTWTPSDIPSGTYAVRISDESGEPNYSTQFSYLGTATAFPSQTVSETSAVTTATSASLTTLSTITTTSEATATTEESSTTTEETTTTETRHSTTTTGSATTTRVDPTVTPDNTNAGQRFASPLALVLVTVAALVFFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFT5</accession>
    <name>G0SFT5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0072060</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697468.1">
        <property type="nucleotide sequence ID" value="XM_006697405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFT5"/>
    <dbReference type="STRING" id="759272.G0SFT5"/>
    <dbReference type="GeneID" id="18261244"/>
    <dbReference type="KEGG" id="cthr:CTHT_0072060"/>
    <dbReference type="eggNOG" id="ENOG502SI0U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020030_3_1_1"/>
    <dbReference type="OMA" id="KQKAMGH"/>
    <dbReference type="OrthoDB" id="5380854at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF51">
        <property type="entry name" value="ACRIFLAVINE SENSITIVITY CONTROL PROTEIN ACR-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS17850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="504" mass="55523" checksum="F2A7C1C35ABE207C" modified="2011-10-19" version="1">MPGPSRVSAGALSAPASTSTALRPASSQSCSPPCYNCRRRRLRCDRSRPTCRKCWVSGEECLGYGTVLRWANGPAIRGKLAGGRFGSPPPITSPREPDENEALVLHQTLLDPLLATLDKKSRHYIHHFATAVCQDLVSVDQHDRNPFRTLVPLSGKFDFLEAIIVATGAMHMASLHGSRQTYQPSRTELIDALVAKDKAIRLLRTTISDLMSRPENQAMVLAATVFLINVDLIDSGKGGWQAHIEAATALMSSVHQLAQMMDPSLVTLVDAIAADCLTYRVLSAAISGVALPPRAEKELVDLFSILKRAEPYSYHCCPPDILRIILSASCLGDEGRIEAALMLFQQARTFDVVNWVYSIRGLSPNDDLPVRVSIALAHRATACLYVLLAVPEAATGSLSPDMLVEEVLNHLAGVPIDHVLLKGTVWPTFMAGAQTDNPKQRQWCIERLEAVWARNPWICPWGYIRTAIEMLNRLWQARDSNPAGPEKTNWLQEVRSMRDKCLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFU6</accession>
    <name>G0SFU6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL15/eL18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0072180</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697479.1">
        <property type="nucleotide sequence ID" value="XM_006697416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFU6"/>
    <dbReference type="STRING" id="759272.G0SFU6"/>
    <dbReference type="GeneID" id="18261256"/>
    <dbReference type="KEGG" id="cthr:CTHT_0072180"/>
    <dbReference type="eggNOG" id="KOG0846">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055188_5_0_1"/>
    <dbReference type="OMA" id="VVTRYYT"/>
    <dbReference type="OrthoDB" id="361383at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_uL15_bac-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934:SF11">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="5">
        <location>
            <begin position="125"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="56"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS17861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="311" mass="34686" checksum="11EE290C97534F41" modified="2011-10-19" version="1">MPPRLPLAQATRSAAAAAIDTSVCRPIAAASSLVFLFAGLSIQSSQQTRSASILSSLSDNPGAYHKRQRVGRGPSSGYGKTSGRGTKGQWQHGKVKPWFQGGQTPLIVSHGRMGFINHRAPDMHVVNLDRLQEWIDAGRIDPTKQITPREIIKSGIVGRHIKDGIKLLARGKEKLRTPIDICVSRASEEAIKAVEAIGGKVTTRYYTKVAIKRLVQGESIHTDQPIPYGKQHVKEVLEKVRNSDKYYYLLPDPTSRKDIEYYRDPAHRGYLSHTLKPGESPSLYFKVPSTTNEFAKPKSKRKQQEMEYKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFV9</accession>
    <name>G0SFV9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0072310</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697492.1">
        <property type="nucleotide sequence ID" value="XM_006697429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFV9"/>
    <dbReference type="STRING" id="759272.G0SFV9"/>
    <dbReference type="GeneID" id="18261269"/>
    <dbReference type="KEGG" id="cthr:CTHT_0072310"/>
    <dbReference type="eggNOG" id="ENOG502RE6I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_8_6_1"/>
    <dbReference type="OMA" id="CRKYAYD"/>
    <dbReference type="OrthoDB" id="3358371at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF26">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="10"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS17874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="356" mass="39613" checksum="88942638D932F945" modified="2011-10-19" version="1">MASENTQQAKKLIVVVGATGNQGGSVARRFLQDPQYAVRGLTRNPESPASKELAALGAEMVKAELEDVESLKAAFKGANVIFSVTQYWQPYSRPDCRAKAKELGVSIRQYAGMVELQHGRNIADAAATVVDTLVPNGFLVSTLSHAGKCSNGRFTNLYHFDCKAEIFPDYVNEKYPELAAKMSCIHTGFFTTSHLILPDSYFKKDLLTRPQVADNTFEMRFPMRPDRPTWHLDVNHDLGNFVYAVSKMPPGKAYMAGEQRTWPEWAAAWASVTGATITYKQVTREDMVNETPDKDVGLEVAIMFEYSDDPGYDGGMELLTVEDLRKAGFDCPMSTLEESFRRQDFAYVLNKPIASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGA2</accession>
    <name>G0SGA2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0065600</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696859.1">
        <property type="nucleotide sequence ID" value="XM_006696796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGA2"/>
    <dbReference type="STRING" id="759272.G0SGA2"/>
    <dbReference type="GeneID" id="18260598"/>
    <dbReference type="KEGG" id="cthr:CTHT_0065600"/>
    <dbReference type="eggNOG" id="ENOG502QU1D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031855_0_0_1"/>
    <dbReference type="OrthoDB" id="5426798at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF11">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="182"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS17241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="403" mass="44787" checksum="06F9E11089274CEC" modified="2011-10-19" version="1">MGFATYIEPRPRPTLPDTPPELLTPDSASFPSKASEERASWNPRAPPSPPMSNYDPVKSRDTSTSSSTRGSEEALSRSESTFDQRTPRQQLPPLSSILASIARDPPFHFTYSDRSSSYTPSSSLDRPLGSSAYFPPSTTSSAFSQPRSFQDLRHQERPQIPPLSQVFSQTLELQPRYEQRSDIRFDYTSSTNRWPAPTPQDASRTYSSRDREPQLYQPTADRYSSANVSGAGMDESRRMSYREQLTPSTPVNNSQVPPPSDVPDEVPPAKDALGPKIWAGTHYLPRFVRAAEVPGEGLCYFYDDGSHCKTVIDGEAVNAQWGVTKAGKPRKRLAIACMTCREKKIKCDPDYPRCLQCEKFGRGSRRERHGSVDTSYGARSTRAASTIVIEDADGRSHAATQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGC2</accession>
    <name>G0SGC2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">rRNA processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0065800</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="9 10 11" key="2">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e56910" last="e56910">
            <title>Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation during pre-60S biogenesis.</title>
            <authorList>
                <person name="Lau B."/>
                <person name="Huang Z."/>
                <person name="Kellner N."/>
                <person name="Niu S."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
                <person name="Cheng J."/>
            </authorList>
            <dbReference type="PubMed" id="37129998"/>
            <dbReference type="DOI" id="10.15252/embr.202356910"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696879.1">
        <property type="nucleotide sequence ID" value="XM_006696816.1"/>
    </dbReference>
    <dbReference type="PDB" id="8I9P">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="CU=1-451"/>
    </dbReference>
    <dbReference type="PDB" id="8I9R">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="CU=1-451"/>
    </dbReference>
    <dbReference type="PDB" id="8I9T">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.60 A"/>
        <property type="chains" value="CU=1-451"/>
    </dbReference>
    <dbReference type="PDB" id="8I9V">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="CU=1-451"/>
    </dbReference>
    <dbReference type="PDB" id="8I9W">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="CU=1-451"/>
    </dbReference>
    <dbReference type="PDB" id="8I9X">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="CU=1-451"/>
    </dbReference>
    <dbReference type="PDB" id="8I9Y">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="CU=1-451"/>
    </dbReference>
    <dbReference type="PDB" id="8I9Z">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="CU=1-451"/>
    </dbReference>
    <dbReference type="PDB" id="8IA0">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="CU=1-451"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGC2"/>
    <dbReference type="EMDB" id="EMD-35279"/>
    <dbReference type="EMDB" id="EMD-35281"/>
    <dbReference type="EMDB" id="EMD-35283"/>
    <dbReference type="EMDB" id="EMD-35285"/>
    <dbReference type="EMDB" id="EMD-35286"/>
    <dbReference type="EMDB" id="EMD-35287"/>
    <dbReference type="EMDB" id="EMD-35288"/>
    <dbReference type="EMDB" id="EMD-35289"/>
    <dbReference type="EMDB" id="EMD-35290"/>
    <dbReference type="SMR" id="G0SGC2"/>
    <dbReference type="STRING" id="759272.G0SGC2"/>
    <dbReference type="GeneID" id="18260618"/>
    <dbReference type="KEGG" id="cthr:CTHT_0065800"/>
    <dbReference type="eggNOG" id="KOG3080">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036007_2_0_1"/>
    <dbReference type="OMA" id="DAHKGRD"/>
    <dbReference type="OrthoDB" id="443772at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008610">
        <property type="entry name" value="Ebp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028">
        <property type="entry name" value="RRNA PROCESSING PROTEIN EBNA1-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028:SF0">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EBP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05890">
        <property type="entry name" value="Ebp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9 10 11" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="322"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="387"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS17261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="8I9P"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="8I9R"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="8I9T"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="50167" checksum="CACBC59AA0F24AEB" modified="2011-10-19" version="1">MAKKGATQSPKAGSKPNSQTGDAQSKNQKADRRKSNEPVVEKVAEKEEQREEETEESEEDESEDEQLQIRANGNNESDSEEDSDENSEDEDESDDDSGDEHPTHHIDFEAIDDSDSESELDSDEENDKKQDSNKAQNGMSEDKMDVDKDGEDKSGDEEDEEEEIDVEELEPEDEEDEEQIAAGTRTRQTINNKEGLLTALRRIQLDINPKTTPFSFHQSVVASKRTEDSIPQIEDDLQRELAFMNQALEAARLGRSLLRKEGVPFTRPTDYFAEMVRTDATMEKVKQKLIEEATAKKAAAEARKQRDLKKFGKAVQVQKQLERAKQKREALDKINQLKRKRAEGGSAALGATEADDPFDVAVDNELSRDSKPKKRRADGDHPVPNPKRQKKNAKYGFGGKKRGSKSGDAISSGDLSGFSVKRMKYGGGAGGGKKKANRPGKARRKAAAAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGD1</accession>
    <name>G0SGD1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0065890</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696888.1">
        <property type="nucleotide sequence ID" value="XM_006696825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGD1"/>
    <dbReference type="STRING" id="759272.G0SGD1"/>
    <dbReference type="GeneID" id="18260627"/>
    <dbReference type="KEGG" id="cthr:CTHT_0065890"/>
    <dbReference type="eggNOG" id="ENOG502QRH7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047791_0_0_1"/>
    <dbReference type="OMA" id="ICCWEAN"/>
    <dbReference type="OrthoDB" id="4849731at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409216" evidence="3">
        <location>
            <begin position="20"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS17270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="467" mass="50218" checksum="275B2B6246209C8F" modified="2011-10-19" version="1">MKASLGLVALSSVLGVVDAQLVWWHRDDEQTYHPPQQTEQPLKELLQNAFDPMPTPPPKASILQARAEPNNTCGFMRGDPDSALYCARTEFCAYHASLSHYYLGCCNDDGLSCGLWTTCLDSTESSRFTLDGTTMLCDDPEFPYCYTHIYRDPVWTGFTVLGCGVRRGRGDIYYTPLRVTDSSRSVIYTTSTTSRSSSSRSTSDPIFSSSSTDPIPPPTPPPEPEENNTGAIIGGVVGGVAALGLIGLVAVIFMRRKKHDDNQPSPPAVPVVLQQPNQPSPPAPAPTNPHMSQVYSIPSTSPAQSSFDPRQSMAAGQTGISPMGSPSPISPTPPSAAFGTLQTTPSPQSSEQQQQQQWMQTGNVLPHTNPAYASAGFNMYSDPHAPQLLQPQLAGYGQPVPQQQSVNYGIAAVSGQQEPKQYTAWQSGPVELPTQNYRYDTSGVNELHGSETFGEGAAGRGNVARHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHC9</accession>
    <name>G0SHC9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">tRNA dimethylallyltransferase</fullName>
            <ecNumber evidence="8 9">2.5.1.75</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0069580</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = N(6)-dimethylallyladenosine(37) in tRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 10">Belongs to the IPP transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="8 9"/>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697236.1">
        <property type="nucleotide sequence ID" value="XM_006697173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHC9"/>
    <dbReference type="STRING" id="759272.G0SHC9"/>
    <dbReference type="GeneID" id="18260996"/>
    <dbReference type="KEGG" id="cthr:CTHT_0069580"/>
    <dbReference type="eggNOG" id="KOG1384">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032616_2_3_1"/>
    <dbReference type="OMA" id="WGLHLKS"/>
    <dbReference type="OrthoDB" id="775260at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030666">
        <property type="entry name" value="IPP_transferase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088:SF89">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01715">
        <property type="entry name" value="IPPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039110">
        <property type="entry name" value="IPP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 9" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="450"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR039110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS17618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="485" mass="54792" checksum="846CDC3F153B78A4" modified="2011-10-19" version="1">MKPLIIIYGSTGTGKSDLAVELALRFNGEIINADAMQMYRGLPVITNKLTVEEQRGIPHHLLGSIELDEEPWTVAHFKRDATRIIDEIRARGKLPIVVGGTSYYLDSLLFEGKLVEDNDDPEGKLWSRDLAARYPILTAPTEEVLAKLREVDPVMAAKWHPNDDRKIRHSLEIYYATGRRASEIYEEQRNRKLQAKSGTNGSNGAPELEIGEVLLFWLYAHQEELKERLAQRVDKMVERGLLDEVSEMYDYLQSRLSACETVDRTKGIWQSIGFRQFEPYLSTLRQNPSDPNLEKLKQAGIEETKIATRQYAKTQVRWVTMKTITSLQEENLLDRFYLLDSTDISRWHDEVLNKGVDLAAKFLACKPLPKPEEVSDTARQVLAEKVARAGKKDTPCHKVCELCNKTLVTEELWQKHIKGRKHTNAVRSAKRRALIPAHLAPTRAVVVVENGNKDDESKEEESAAPDAASESETAIPAVTTAESPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHN3</accession>
    <name>G0SHN3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Iron-sulfur cluster assembly factor IBA57 homolog, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0070650</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="J. Biol. Chem." volume="298" first="102465" last="102465">
            <title>The iron-sulfur cluster assembly (ISC) protein Iba57 executes a tetrahydrofolate-independent function in mitochondrial [4Fe-4S] protein maturation.</title>
            <authorList>
                <person name="Muhlenhoff U."/>
                <person name="Weiler B.D."/>
                <person name="Nadler F."/>
                <person name="Millar R."/>
                <person name="Kothe I."/>
                <person name="Freibert S.A."/>
                <person name="Altegoer F."/>
                <person name="Bange G."/>
                <person name="Lill R."/>
            </authorList>
            <dbReference type="PubMed" id="36075292"/>
            <dbReference type="DOI" id="10.1016/j.jbc.2022.102465"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 61-476</scope>
        <scope>DISULFIDE BONDS</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GcvT family. CAF17/IBA57 subfamily.</text>
    </comment>
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        <property type="resolution" value="2.40 A"/>
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        <property type="term" value="P:iron-sulfur cluster assembly"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="ygfZ_signature"/>
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        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="disulfide bond" description="Interchain" evidence="8">
        <location>
            <position position="304"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00093637"/>
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        <source>
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            <dbReference type="Proteomes" id="UP000008066"/>
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    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="7Z3H"/>
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    </evidence>
    <sequence length="476" mass="52175" checksum="7D42C3D33F53F24E" modified="2011-10-19" version="1">MQATWRLQRVLTSPAAGVLLRTRSCARPRTAVAVAVARKPLPQHSNALPSPPPIHQGGFPRHYTSLTFGPINPSIPSSYAPSGISHLLSRQLVVVYGPDAAKYLQGMVTANVYMPGSGSMVRTDRGYYAALLTGQGRVLYDVFIYPLTDSKHLQRVLPSADVEGAAFLIEVDKDQAGLLVDHIKRYRVRAKVKVKVVDVEEVAVWHAWDPNGLGEASVNDLLVTPDCRTPAMGSRILHFGGPDGNAIQNFAERCQLQVLPQEYYVLHRITQGVPEGQTELLKMSAIPHESNLDLMGGIDFRKGCYVGQELVTRTEHRGVVRKRVLPCVVYEGSQGQAVDIRATGGDLGGLYTDRPIAGLSSAREIASETNIVRVSGKGRGVGKWLRGIGNVGLAVCRLDVMTDLPIPGETPAGEDGVPEVREVKGEFTIEGDEGPLRIKAVPPAWLRRELMEKWEVKNEQNMVRFQREAIESEEEM</sequence>
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<entry dataset="Swiss-Prot" created="2025-02-05" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHQ2</accession>
    <name>RL11_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Large ribosomal subunit protein uL5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">60S ribosomal protein L11</fullName>
            <shortName evidence="3">ctRPL11</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HT_0072970</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2015" name="Nat. Commun." volume="6" first="6510" last="6510">
            <title>Symportin 1 chaperones 5S RNP assembly during ribosome biogenesis by occupying an essential rRNA-binding site.</title>
            <authorList>
                <person name="Calvino F.R."/>
                <person name="Kharde S."/>
                <person name="Ori A."/>
                <person name="Hendricks A."/>
                <person name="Wild K."/>
                <person name="Kressler D."/>
                <person name="Bange G."/>
                <person name="Hurt E."/>
                <person name="Beck M."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="25849277"/>
            <dbReference type="DOI" id="10.1038/NCOMMS7510"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (3.40 ANGSTROMS)</scope>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="476" last="476">
            <title>High-resolution structures of a thermophilic eukaryotic 80S ribosome reveal atomistic details of translocation.</title>
            <authorList>
                <person name="Kisonaite M."/>
                <person name="Wild K."/>
                <person name="Lapouge K."/>
                <person name="Ruppert T."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="35079002"/>
            <dbReference type="DOI" id="10.1038/s41467-022-27967-9"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.90 ANGSTROMS)</scope>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e56910" last="e56910">
            <title>Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation during pre-60S biogenesis.</title>
            <authorList>
                <person name="Lau B."/>
                <person name="Huang Z."/>
                <person name="Kellner N."/>
                <person name="Niu S."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
                <person name="Cheng J."/>
            </authorList>
            <dbReference type="PubMed" id="37129998"/>
            <dbReference type="DOI" id="10.15252/embr.202356910"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.10 ANGSTROMS)</scope>
    </reference>
    <reference evidence="15 16 17" key="5">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e57984" last="e57984">
            <title>Structural insights into coordinating 5S RNP rotation with ITS2 pre-RNA processing during ribosome formation.</title>
            <authorList>
                <person name="Thoms M."/>
                <person name="Lau B."/>
                <person name="Cheng J."/>
                <person name="Fromm L."/>
                <person name="Denk T."/>
                <person name="Kellner N."/>
                <person name="Flemming D."/>
                <person name="Fischer P."/>
                <person name="Falquet L."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="37921038"/>
            <dbReference type="DOI" id="10.15252/embr.202357984"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.12 ANGSTROMS)</scope>
    </reference>
    <reference evidence="11 12" key="6">
        <citation type="journal article" date="2023" name="Nat. Struct. Mol. Biol." volume="30" first="670" last="677">
            <title>Structural inventory of cotranslational protein folding by the eukaryotic RAC complex.</title>
            <authorList>
                <person name="Kisonaite M."/>
                <person name="Wild K."/>
                <person name="Lapouge K."/>
                <person name="Gese G.V."/>
                <person name="Kellner N."/>
                <person name="Hurt E."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="37081320"/>
            <dbReference type="DOI" id="10.1038/s41594-023-00973-1"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.20 ANGSTROMS)</scope>
    </reference>
    <reference evidence="10" key="7">
        <citation type="journal article" date="2023" name="Nat. Struct. Mol. Biol." volume="30" first="1119" last="1131">
            <title>Structure of nascent 5S RNPs at the crossroad between ribosome assembly and MDM2-p53 pathways.</title>
            <authorList>
                <person name="Castillo Duque de Estrada N.M."/>
                <person name="Thoms M."/>
                <person name="Flemming D."/>
                <person name="Hammaren H.M."/>
                <person name="Buschauer R."/>
                <person name="Ameismeier M."/>
                <person name="Bassler J."/>
                <person name="Beck M."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="37291423"/>
            <dbReference type="DOI" id="10.1038/s41594-023-01006-7"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.50 ANGSTROMS) IN COMPLEX WITH RPL5; RRS1; RPF2; SYO1 AND 5S RNA</scope>
        <scope>FUNCTION</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <reference evidence="14" key="8">
        <citation type="journal article" date="2024" name="Nat. Commun." volume="15" first="716" last="716">
            <title>Methionine aminopeptidase 2 and its autoproteolysis product have different binding sites on the ribosome.</title>
            <authorList>
                <person name="Klein M.A."/>
                <person name="Wild K."/>
                <person name="Kisonaite M."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="38267453"/>
            <dbReference type="DOI" id="10.1038/s41467-024-44862-7"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.10 ANGSTROMS)</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:37291423). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of a hexameric 5S RNP precursor complex, composed of 5S RNA, RRS1, RPF2, RPL5, RPL11 and SYO1; this complex acts as a precursor for ribosome assembly.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS16972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_006697491.1"/>
    </dbReference>
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        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.40 A"/>
        <property type="chains" value="C=1-173"/>
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    <dbReference type="PDB" id="7OLC">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="LJ=1-173"/>
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    <dbReference type="PDB" id="7OLD">
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        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="LJ=1-173"/>
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        <property type="resolution" value="3.50 A"/>
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        <property type="resolution" value="3.30 A"/>
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        <property type="resolution" value="3.10 A"/>
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        <property type="resolution" value="2.63 A"/>
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        <property type="resolution" value="2.91 A"/>
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        <property type="resolution" value="2.19 A"/>
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    <dbReference type="InterPro" id="IPR057266">
        <property type="entry name" value="Ribosomal_uL5_euk/arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_uL5_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003258">
        <property type="entry name" value="PRK04219.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000461684" description="Large ribosomal subunit protein uL5">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="helix" evidence="19">
        <location>
            <begin position="9"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="strand" evidence="18">
        <location>
            <begin position="17"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="helix" evidence="18">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="strand" evidence="18">
        <location>
            <begin position="67"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="helix" evidence="18">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="turn" evidence="18">
        <location>
            <begin position="88"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="strand" evidence="19">
        <location>
            <begin position="91"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="helix" evidence="19">
        <location>
            <begin position="94"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="strand" evidence="19">
        <location>
            <begin position="99"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="strand" evidence="18">
        <location>
            <begin position="103"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="turn" evidence="18">
        <location>
            <begin position="110"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="turn" evidence="18">
        <location>
            <begin position="119"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="strand" evidence="18">
        <location>
            <begin position="126"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="helix" evidence="19">
        <location>
            <begin position="137"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="turn" evidence="19">
        <location>
            <begin position="151"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="helix" evidence="18">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="strand" evidence="19">
        <location>
            <begin position="171"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="37291423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000305" key="3">
        <source>
            <dbReference type="PubMed" id="37291423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="EMBL" id="EGS16972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="7">
        <source>
            <dbReference type="PDB" id="5AFF"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="8">
        <source>
            <dbReference type="PDB" id="7OLC"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="9">
        <source>
            <dbReference type="PDB" id="7OLD"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="10">
        <source>
            <dbReference type="PDB" id="7OZS"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="11">
        <source>
            <dbReference type="PDB" id="7Z3N"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="12">
        <source>
            <dbReference type="PDB" id="7Z3O"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="13">
        <source>
            <dbReference type="PDB" id="8I9R"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="14">
        <source>
            <dbReference type="PDB" id="8OO0"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="15">
        <source>
            <dbReference type="PDB" id="8PV1"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="16">
        <source>
            <dbReference type="PDB" id="8PV2"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="17">
        <source>
            <dbReference type="PDB" id="8PV3"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PDB" id="5AFF"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="19">
        <source>
            <dbReference type="PDB" id="7OZS"/>
        </source>
    </evidence>
    <sequence length="173" mass="20080" checksum="7844055FD6457111" modified="2011-10-19" version="1">MSSEKAQNPMRELRIQKLVLNISVGESGDRLTRAAKVLEQLSGQTPVYSKARYTVRQFGIRRNEKIAVHVTVRGPKAEEILERGLKVKEYELRRRNFSETGNFGFGISEHIDLGIKYDPSIGIYGMDFYCCMTRPGERVAKRRRCKSRIGASHRITREETIRWFKQRFDGIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHS3</accession>
    <name>G0SHS3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0073180</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS16993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697575.1">
        <property type="nucleotide sequence ID" value="XM_006697512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHS3"/>
    <dbReference type="STRING" id="759272.G0SHS3"/>
    <dbReference type="GeneID" id="18261356"/>
    <dbReference type="KEGG" id="cthr:CTHT_0073180"/>
    <dbReference type="eggNOG" id="KOG3207">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017716_3_1_1"/>
    <dbReference type="OMA" id="SEESHMF"/>
    <dbReference type="OrthoDB" id="5273213at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45617">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CAP-Gly" evidence="3">
        <location>
            <begin position="23"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS16993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="592" mass="66325" checksum="21FBCAC41FC963DB" modified="2011-10-19" version="1">MSAPYIGQRRSYDGALCTVRYIGDVAGTSGSWLGVEWDDPSRGKHDGQHKGVRYFSCKSKSPTAASFVRPTRPADAPQSFLAALHKKYVSDPDKDKEPPRQVYFNSKVAEEVGFDKVRRKQAKLDELKYVILDGLRVARAYEEGAEERPIGEVCPEIRELDLSRNLFERFGPVVEICRELKHLKSLRINGNRFQNVQEDEKLHESDGAFNGVTELALEDTLLDWQEICHIAAKYPALTTLHAGLNQFSTLTSIPEVPFTSTLVSIHLEFNEFSSLFDLAPLTSIASLRNLLLKGNKIDTIAPPFSSPPVFSQTLQHLDISYNRVSSWSFVDALNTVFPGLTSLRFTHNPIYDDPDLDTQESYPSTASSTTAKGKGIAKSDEAFMLTIARLASLKTLNFSPITANDRSDAEMFYLSRIARQLSSVPEAAEKEVLARHRRWAELCEVYGEPAVVRQTELNPNFLEARLIKAELIPAWEGSPEKKCVQIPKAFDIYAVKGIVGRLFGLPPLGLKLVWETGEWDPAAGFEEDEAGEGEEDLEAEWERKVDEGVVVGEGLEGKKGRWVKREVELKDGPRQFGYCVDGLEVRIRVEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHY0</accession>
    <name>G0SHY0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0073770</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697632.1">
        <property type="nucleotide sequence ID" value="XM_006697569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHY0"/>
    <dbReference type="SMR" id="G0SHY0"/>
    <dbReference type="STRING" id="759272.G0SHY0"/>
    <dbReference type="GeneID" id="18261415"/>
    <dbReference type="KEGG" id="cthr:CTHT_0073770"/>
    <dbReference type="eggNOG" id="KOG0243">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001485_33_2_1"/>
    <dbReference type="OMA" id="DWETFDQ"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000073">
        <property type="term" value="P:initial mitotic spindle pole body separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047149">
        <property type="entry name" value="KIF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025901">
        <property type="entry name" value="Kinesin-assoc_MT-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970:SF12">
        <property type="entry name" value="KINESIN FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13931">
        <property type="entry name" value="Microtub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="12">
        <location>
            <begin position="79"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="981"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1018"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1207"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="458"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="718"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="981"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1023"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1091"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1135"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1221"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="165"/>
            <end position="172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS17050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1230" mass="134514" checksum="B1FF982555F75389" modified="2011-10-19" version="1">MGPPPRPTAGRASGIRPPTRQATTRQQQSSQNAPRHASISRLQRAASPAESVASMSTATTTGAKRKERDFDLDDMEATNINVVVRCRGRNEREVRENSHVVVRTEGTKGRLLELAMGPNAVSNKSYEFDRVFSQAADQAMIFEDVVRPVLDEMLAGYNCTIFAYGQTGTGKTYTMSGDLTETMGMLSDNAGIIPRVLQSLFKKLDMDEKEYSVRVSFIELYNEELRDLLSSDENKQLKIFDDTSRKGHTTTIVQGAEERYILNAAEGLRCLQEGSVKRQVAATKCNDLSSRSHTVFTITVYQKHETDSNGEDMFMLGKLNLVDLAGSENIQRSGASDKRAAEAGLINKSLLTLGPDSAAARLAGWTHQDVHHCYDLARAQQPRGDHLDARLCLPGKNIRNKPQLNALTNKKALLREFIVEIERLKAELIATRQRNGVYLSNEAYEELTVQNESRRILTEEQAAKIETLEANLKNKLQEFLALRSNFLGLKKENEELSDELGRSKDALEQTELILAATKKSLEEETMLRKAHQETEQKLASLGGQLVGTLKRTVSDIDGLRAKNKRRAELHSLNRNTWEKSQARVAEVTELVEDRLDAFRQDQERHISSVSRRIQAFVKEELDQLAETQTLLDTSLADFSSARARLLAQQERSKEELDTVLEDIKLVRDKVKQRVGSSLQAISTAAERIAADVLGELSALHTHLHDSYASLGRDVKSLFDDLLKHMRAQKAESDRLRRELEAATQAMIEANASHAARMKEVLEEERTQAAQERQALLAQIAKLITTQADLQDSRLTNRALQIQSSMEDASTAFASSVDEYTSGMRAWSEKDDVVLAEVSRSRDALRTQLQSDWAAAERYSTAIQTATKAVHAETVRVVEGQVEDLDVQMGDLDAFVARARQQNASGSGKCAEAVRGVSSAVEGGLGRLAERFGEVGERMQRLGDAVEGDVEVVEEGMDQLEQSVVRPLAGLREEVVKIKMKEYEPTGKTPEKTSYPIPTNLPRTAPHEILLASMRGEPIPELDLGPEEQEQEQEQEQEQDLPPLPPLSSADPSSPTPVPVPTPQVTKKKVPQATPSKQKPAVLPDAVPTPLPAAKSPAPHQPSASKPPASASASRIPMSMGSATAAPASLREVNPNLASPTAVKSSSNNTASTAEKDGSSIASVLALPPGGDAPVKVAAAAAARGAVGKRMGTAGVSSKGRKAGLVGISEGVENVPPPVRTGGRRKSPRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G1DJA5</accession>
    <name>G1DJA5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytochrome c oxidase subunit 1</fullName>
            <ecNumber evidence="15">7.1.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CTHT_m000430</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="18"/>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Mitochondrion inner membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="15"/>
    <dbReference type="EMBL" id="JN007486">
        <property type="protein sequence ID" value="AEI26013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004769786.1">
        <property type="nucleotide sequence ID" value="NC_015893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G1DJA5"/>
    <dbReference type="STRING" id="759272.G1DJA5"/>
    <dbReference type="GeneID" id="11030332"/>
    <dbReference type="KEGG" id="cthr:CTHT_m000430"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01663">
        <property type="entry name" value="Cyt_c_Oxidase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.210.10:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="entry name" value="Cytochrome c oxidase-like, subunit I domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023615">
        <property type="entry name" value="Cyt_c_Oxase_su1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033944">
        <property type="entry name" value="Cyt_c_oxase_su1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422:SF18">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="Cytochrome c oxidase subunit I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00077">
        <property type="entry name" value="COX1_CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 15" id="KW-0186">Copper</keyword>
    <keyword evidence="10 15" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 15" id="KW-0349">Heme</keyword>
    <keyword evidence="12 15" id="KW-0408">Iron</keyword>
    <keyword evidence="14 15 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15 18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 15 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="188"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="377"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="418"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome oxidase subunit I profile" evidence="17">
        <location>
            <begin position="6"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AEI26013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="545" mass="60138" checksum="46B58512BBEBED55" modified="2011-10-19" version="1">MSRPISMWVERWFLSSNAKDIGTLYLIFALFSGLLGTAFSVLIRMELSGPGVQYIADNQLYNSIITAHALLMIFFMVMPALIGGFGNFLLPLLIGGPDMAFPRLNNISFWLLPPSLILLVFAACVEGGVGTGWTVYPPLAGVQSHSGPSVDLAIFALHLSGISSLLGSMNFITTVINMRTPGIRLHKLALFGWAVVITAVLLLLSLPVLAGGITMLLTDRNFNTSFYEVAGGGDPILFQHLFWFFGHPEVYILIIPAFGIISTTISAFSNKSVFGYIGMVYAMMSIGILGFIVWSHHMYTVGLDVDTRAYFTAATLIIAVPTGIKIFSWLATCYGGSIILTPSMLFAIGFVFMFTIGGLSGVMLANASLDIAFHDTYYVVAHFHYVLSMGAVFAMFSGWYFWIPKLIGLNYNMTMSKVQFWILFIGVNLTFFPQHFLGLQGMPRRISDYPDAFAGWNLISSFGSLISVIATGVFLYIVYKQLIEEIIASRFPWLRVQYNFDNRHALLNRSYPSLEWAVNSPPKPHSFDSLPVQSSLGTSIHVFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0RY27</accession>
    <name>G0RY27_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0005170</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691055.1">
        <property type="nucleotide sequence ID" value="XM_006690992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RY27"/>
    <dbReference type="GeneID" id="18254555"/>
    <dbReference type="KEGG" id="cthr:CTHT_0005170"/>
    <dbReference type="eggNOG" id="ENOG502S55X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062870_0_0_1"/>
    <dbReference type="OMA" id="EVRVCWL"/>
    <dbReference type="OrthoDB" id="3360032at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031501">
        <property type="term" value="C:mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019433">
        <property type="entry name" value="GPI_ManTrfase_II_coact_Pga1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28022">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2 SUBUNIT PGA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28022:SF1">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2 SUBUNIT PGA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10333">
        <property type="entry name" value="Pga1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409134" evidence="2">
        <location>
            <begin position="21"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="236" mass="26004" checksum="B0A2F881E0F8A8AB" modified="2011-10-19" version="1">MTALFPILLAALLLARPILSNTEKTIFLAPAASVASSDGRVSLLPLQKLPALTPEHNTLRTKLPAIFPNATYPRGAATWFRLDGLEEGKRYEVRVCWAATQPTNFYLITHTLSDVLSNPELFSSLQSYAPSPSFASAFEPDYLSEKPTILLRIQAQADFYTPPHGPHGELMRSPQPVDADVILDPYILNVLPRSLLGTVIYITGFGIVSWFVARRIARWVEGVASGDRDGKGEKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0RY70</accession>
    <name>G0RY70_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative cytoplasm protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0005640</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691098.1">
        <property type="nucleotide sequence ID" value="XM_006691035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RY70"/>
    <dbReference type="STRING" id="759272.G0RY70"/>
    <dbReference type="GeneID" id="18254602"/>
    <dbReference type="KEGG" id="cthr:CTHT_0005640"/>
    <dbReference type="eggNOG" id="KOG1763">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042870_1_0_1"/>
    <dbReference type="OMA" id="GREMFYF"/>
    <dbReference type="OrthoDB" id="278280at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032378">
        <property type="entry name" value="ZC3H15/TMA46_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681:SF0">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681">
        <property type="entry name" value="ZINC FINGER-CONTAINING PROTEIN P48ZNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16543">
        <property type="entry name" value="DFRP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="172"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="172"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="43"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="323"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS23856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="369" mass="42194" checksum="1DA47C0C684F9D77" modified="2011-10-19" version="1">MPPKPQNKGKKPDAKKIIEDKTFGMKNKKGAVAKKQIAALQKSMQASGSAEEKRKAAERAQREREKKAAEEARKEAEMLLNKPVQVQKVPFGVDPKTVVCIFFKKGNCEKGKKCKFSHDLEMERKTEKKSLYEDTRQTKQEEEEKKRQETSADWDEEKLRSVILSKKGNQRTTTDKVCKYFIQAIEDGKYGWFWMCPNGGDKCMYKHALPPGYVVKTKEQRAAEKAARENAAAKSITLEEFIESERLKLTGTLTPVTPETFAKWKKERLDKKAAEEQLRKAKENTGRALFESGMYKEEDSEDEGDSAWNLEKLRKETEALRIKREEERLARQYGLIPEGTTDDGETNEKEKEPEGDEKGADEADKAPNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYB5</accession>
    <name>G0RYB5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0006100</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691143.1">
        <property type="nucleotide sequence ID" value="XM_006691080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYB5"/>
    <dbReference type="STRING" id="759272.G0RYB5"/>
    <dbReference type="GeneID" id="18254648"/>
    <dbReference type="KEGG" id="cthr:CTHT_0006100"/>
    <dbReference type="eggNOG" id="ENOG502R9U6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1885523_0_0_1"/>
    <dbReference type="OMA" id="WNPSSHE"/>
    <dbReference type="OrthoDB" id="4525115at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="157" mass="17262" checksum="2A2279413BFD334C" modified="2011-10-19" version="1">MSDKPERMTWDHKADHDLLSSIVQELAPSQEQLRGVMRRMHELGYSCTLKAITQHLQKLRRKDEKKAGNGEDGASSAATTPAKTPRRRAVAAGSARKGGSAKRKASAVDNDNSDTEFKTPSKRGRKAIKKDTTKSEPEIKEESELSEPASPEVMYAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2023-05-03" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYL0</accession>
    <name>G0RYL0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0007070</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691238.1">
        <property type="nucleotide sequence ID" value="XM_006691175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYL0"/>
    <dbReference type="GeneID" id="18254745"/>
    <dbReference type="KEGG" id="cthr:CTHT_0007070"/>
    <dbReference type="HOGENOM" id="CLU_2454529_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS23996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="89" mass="9868" checksum="E0516C73E0145DC6" modified="2011-10-19" version="1">MFVHPDNWLLGGASRRVPPEFWRVDAVHSAPSLKDSLHRVCGSLLPPSSPPLLLKTSISSFPSITRHLFLQADTGYLELELDLDDTQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYM8</accession>
    <name>G0RYM8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase III subunit RPC3</fullName>
            <shortName evidence="8">RNA polymerase III subunit C3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0007250</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS24014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691256.1">
        <property type="nucleotide sequence ID" value="XM_006691193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYM8"/>
    <dbReference type="STRING" id="759272.G0RYM8"/>
    <dbReference type="GeneID" id="18254763"/>
    <dbReference type="KEGG" id="cthr:CTHT_0007250"/>
    <dbReference type="eggNOG" id="KOG2587">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023294_0_0_1"/>
    <dbReference type="OMA" id="KHRFVRH"/>
    <dbReference type="OrthoDB" id="272392at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055207">
        <property type="entry name" value="POLR3C_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013197">
        <property type="entry name" value="RNA_pol_III_RPC82-rel_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008806">
        <property type="entry name" value="RNA_pol_III_Rpc82_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039748">
        <property type="entry name" value="RPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08221">
        <property type="entry name" value="HTH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05645">
        <property type="entry name" value="RNA_pol_Rpc82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22536">
        <property type="entry name" value="WHD_POLR3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase III subunit RPC82-related helix-turn-helix" evidence="11">
        <location>
            <begin position="9"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase III Rpc82 C -terminal" evidence="10">
        <location>
            <begin position="172"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase III subunit RPC3 winged-helix" evidence="12">
        <location>
            <begin position="500"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="383"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="406"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS24014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="662" mass="74776" checksum="E6EF64A3044CF7E9" modified="2011-10-19" version="1">MQVTKPVAELCTLLVDELHGELPSRIFSTLVNKGRSTLPQLAQYTSMTPRQLRHGLAVLVQHNLLYHHLDPGAEFAFYEANVEHAYNLVRTGKILEMVDTSFGPAAKDVMQSLLLSGQTRIGDLLAAYQAKIEQANKKVGTNDTEEFDGEANGVNDDSKNEPVVKSTAHLNSILCRLIEAELIDVVHDKTFESPADVLKIVEKEVMDKYFPNGVKGNKAKAEFQQRIAEGLRKVRDESKSLKRKLEQNGSAAKRRKLFSGLGVATNGSGAQQDEEMDPALDPKQVIRVNYEKCLVDLRNRRLVQFATDMFGETTAYVYGILLKLLTKDIPRCRLDPVLDSVDDDDDDDSKKKGPGVVTTDQILDNLKTSVDLSLGIGKAERHQISSRAANKVQTHPPKKKRLIAEAEVDGEASEDEKEDDESSEGSDYDSNYEETKPNGASGINGANGVTHERRMDRPTQLRQHLMLLAESTQNFVRHCGPNEWTVDFEPVMKALREAELDSVIERTSGRQGLRLVRILRAKGKLDEKALPNVALMRKSELQQKMLEMQTAGFVHVQEVPRDVKADVKKSFFLWYCDVEKSLSRLLETSYVTMLHCLQVLEALRRKEKDVLQTTKRTDVRGREKDAMRKEYYERYARFLACERKLFAQVMRLDDLVSVLRDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYT8</accession>
    <name>G0RYT8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0000540</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690608.1">
        <property type="nucleotide sequence ID" value="XM_006690545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYT8"/>
    <dbReference type="GeneID" id="18254092"/>
    <dbReference type="KEGG" id="cthr:CTHT_0000540"/>
    <dbReference type="HOGENOM" id="CLU_1467983_0_0_1"/>
    <dbReference type="OrthoDB" id="3942396at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="49"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="190" mass="21184" checksum="D42EC73B5558A2FC" modified="2011-10-19" version="1">MPHKPRRTGRQSPPPQGSTPTAGSLLRARTEPPQQPAKKATARIRGVTIDNVYLHPNFDIAINSWRTLCSLQVDPDSFIIMGDFNAHHPDWDPSARPNPKGDMVREWIAARGRHILNPEGPTHRDGRVIDLALAPARAFAEFAYWASDHRALVISVPSRLASRLPPPKRLLKTHFETAAHLLKSFLPSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYX2</accession>
    <name>G0RYX2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small-subunit processome Utp12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0000890</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="8 9 10" key="2">
        <citation type="journal article" date="2019" name="Mol. Cell" volume="75" first="1256" last="1269.e7">
            <title>Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration.</title>
            <authorList>
                <person name="Cheng J."/>
                <person name="Bassler J."/>
                <person name="Fischer P."/>
                <person name="Lau B."/>
                <person name="Kellner N."/>
                <person name="Kunze R."/>
                <person name="Griesel S."/>
                <person name="Kallas M."/>
                <person name="Berninghausen O."/>
                <person name="Strauss D."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="31378463"/>
            <dbReference type="DOI" id="10.1016/j.molcel.2019.06.032"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.50 ANGSTROMS)</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UTP5 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690642.1">
        <property type="nucleotide sequence ID" value="XM_006690579.1"/>
    </dbReference>
    <dbReference type="PDB" id="6RXT">
        <property type="method" value="EM"/>
        <property type="resolution" value="7.00 A"/>
        <property type="chains" value="UE/UI=1-410"/>
    </dbReference>
    <dbReference type="PDB" id="6RXU">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.50 A"/>
        <property type="chains" value="UE/UI=1-410"/>
    </dbReference>
    <dbReference type="PDB" id="6RXV">
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        <property type="resolution" value="4.40 A"/>
        <property type="chains" value="UE/UI=1-410"/>
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    <dbReference type="AlphaFoldDB" id="G0RYX2"/>
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    <dbReference type="EMDB" id="EMD-10054"/>
    <dbReference type="EMDB" id="EMD-10055"/>
    <dbReference type="EMDB" id="EMD-10056"/>
    <dbReference type="SMR" id="G0RYX2"/>
    <dbReference type="STRING" id="759272.G0RYX2"/>
    <dbReference type="GeneID" id="18254127"/>
    <dbReference type="KEGG" id="cthr:CTHT_0000890"/>
    <dbReference type="eggNOG" id="KOG4547">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038849_0_0_1"/>
    <dbReference type="OMA" id="QWSLAAH"/>
    <dbReference type="OrthoDB" id="30195at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
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        <property type="entry name" value="U3_snoRNA-assoc_WDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8 9 10" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="5">
        <location>
            <begin position="165"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="277"/>
            <end position="302"/>
        </location>
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            <begin position="314"/>
            <end position="410"/>
        </location>
    </feature>
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        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
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        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
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        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
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        <location>
            <begin position="288"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="342"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="397"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS23400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="6RXT"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="6RXU"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="6RXV"/>
        </source>
    </evidence>
    <sequence length="410" mass="44608" checksum="37A5A9913284C5AF" modified="2011-10-19" version="1">MSTKRKAATAIAKPVVKQNAKAPTKTRIDESRTAVSTGLALKPVSKHIEEPIESDSESRHSASDDEEVSGDEGQSEEKETEADSGKQKPAASEADGDAVMQDNGEASDGEPTSPTFGDLVRGTTTVDVSASLAAQTTRHEVQRSTAPISATSLGTVLNQALRTDDSDLLESCLQTNDLLIIQNTINRMDSSLAGTLLSKLAARMHRRPGRAFGLMRWIQWTLVAHGGALVTQPDLINRLTELSRVLEERSRGLSSLLALKGKLDMLDAQLKYRKALKMAGSSRNRPSDDDESSAGEEDNADEPAVVYVEGQESLGNALPNGRSARHEDEDEDKQVQIGDMISDSEEDSEDDIDPEAEDDIEEIESIDDEDEVDHDDVEEDEEEEEEDSEAEDAPPAKVRRTSARLSTKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYX8</accession>
    <name>G0RYX8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Armadillo-like helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0000950</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988032">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006690585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYX8"/>
    <dbReference type="GeneID" id="18254133"/>
    <dbReference type="KEGG" id="cthr:CTHT_0000950"/>
    <dbReference type="eggNOG" id="KOG4654">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029861_1_1_1"/>
    <dbReference type="OMA" id="YEATHLN"/>
    <dbReference type="OrthoDB" id="2012278at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039868">
        <property type="entry name" value="ARMD3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013636">
        <property type="entry name" value="ARMH3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13608">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13608:SF3">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08427">
        <property type="entry name" value="ARMH3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01158">
        <property type="entry name" value="DUF1741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Armadillo-like helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS23406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="676" mass="75929" checksum="2AD75E8279C483AB" modified="2011-10-19" version="1">MEQSPLTHQPRPEVFQPKIDDPDDSDRSEGFWKEFFLLRPERQRLRTLLDEIAPADLLHLRLSQTRQFFAQAVAALRSPYGVADLHALETLSTFLTSILSKKYTNPSSDIIELLAGLDHVDAIFSDFIGALEAIIRNGRISAPQECCPNRIGHINQQQQEGQRVVSSRSTCTYTADLQHRAIEVALAVTSGAYQTSLLSYFIQRDLFQAIINCIQSHILFSPSPSGPRISPAFMLLGLLANYNKFEFQNPYQMRLADFVNERVIRGIVRSVGQTCQNLRAQYIDIQDDLPEGWSFAGTLNKIGLGAIAPGRKPTPKPVYDAETVKKMFATLPGHEAAVLLATYDFTHANKLFSLEFVTCPAADKDAKSSPNSSDEAPFSSFISLTSYLVQHAHLSQRTTLYTHLNLMVFRLLIEDPVICKRICSSDDGHKVSVRLCRQRSPYLPLIRGDRVLATAVMDTMVDALTHNLRRRLDVGLYTLCVGILLRIISYMSRTRTRLQYHWHELFRSLLSLIRFLTSYAADLKNLPHIDTLLDHVVNLIALGLSAGETFLPTPVAYDDLFYKVVESGEVLVKFRDTYGLAKRNSNSIETLVQVSQHYKEMLVDGKAGGGGPKKASQLTSLQVFEVIKQGYETLSIQAKEGLDSWEKYREADERTLLKKMARAAVADVRAMVAEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZ22</accession>
    <name>G0RZ22_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0001430</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690692.1">
        <property type="nucleotide sequence ID" value="XM_006690629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZ22"/>
    <dbReference type="STRING" id="759272.G0RZ22"/>
    <dbReference type="GeneID" id="18254181"/>
    <dbReference type="KEGG" id="cthr:CTHT_0001430"/>
    <dbReference type="eggNOG" id="ENOG502TG1H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_462310_0_0_1"/>
    <dbReference type="OrthoDB" id="3934549at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF146">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="31"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="218"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="458"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="498"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="531"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="376"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="402"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="531"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="560"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS23450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="590" mass="63373" checksum="7DF137F8FD7F719D" modified="2011-10-19" version="1">MAAPAADLSGGPALLSISLATAAVALATTVVRFCTRAGITGRFAADDYTSGVAAIVAFVGTIFAIIESTSDNPVRALEFDLLAQPWYLMSATLSKISMCLFFMSMLGRARHWRILLGVFIFTMAAVNLAFALAVNLQCRPLEMLWRPDAEGECWSPSVQMNIGYAQGVRTAKTTETVGKVIYTIHHFYVSLMAILEQNFGLAAANILVFGPLFSSSSSSSYSTSGTGGTSASRSTASRRRRRRTHTPLKDPYSTTSSSSSGVGSHSRSHSRSHSRNHSRSHSRNHSIRSIQRPEMEVPPIPTSLKAGTENNTYLEGLENTTTNLNNTKGKGVAVDEERALESTGPSLRTEGEPASSGPSHSRSRPSDQATYTAFPDSYTLSDATSLTDSSTSTSTSTSDLSDLSEEEDFDPDAIDLSAWPRGIIKTVSVDVTEERIDPPPGMPMPMPMPMPMPFPQIPRPALSRNNSGTSRPGPSTTLPNTGVPNDVVNEEIAKTYDTTHAPPAVGGGRSSVSITSPRGSISVGVGKRTYGGHHHHVRSHSRQPSRLRGLIGGGERDEDRVSEEEDEYEGTGELEQDWEAILRAGPPGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZ27</accession>
    <name>G0RZ27_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0001480</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690697.1">
        <property type="nucleotide sequence ID" value="XM_006690634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZ27"/>
    <dbReference type="GeneID" id="18254186"/>
    <dbReference type="KEGG" id="cthr:CTHT_0001480"/>
    <dbReference type="HOGENOM" id="CLU_813805_0_0_1"/>
    <dbReference type="OrthoDB" id="4927927at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="341" mass="38437" checksum="45AA290295ADEBC9" modified="2011-10-19" version="1">MSLSRGRQVTQIRNPPDPNPDDQTNELQYPALIRLSLPPKHSRPPKGFHIWNTPHPPSLFQCRLYYPTSHSVNTYENYPDQSCFLKAVRLNPSNPIEGITFFLRPEDGRPLGMHVHHPGNGNEKNTVLPLGLPPFLCRGVEWIFAPVGKTDRIVGFGMRHTRQGTDDGRGITKIRHAMLLRLKLAGDAVAGYLIEDYPGWMDQCLAQVKEGEAEGEGTSAGPVTLVYGVPHHGTYWEWFGGYDGTYDNEDVSFQPSFPSPPAFGFWTRVLEYPVSYQTIYSWAPLDNVVEAVFTSITLDSYDDELERSFKGWKAAPLEGYIKLWYDIGDADSRLVITPTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZ60</accession>
    <name>G0RZ60_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative homeostasis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0001810</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690730.1">
        <property type="nucleotide sequence ID" value="XM_006690667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZ60"/>
    <dbReference type="STRING" id="759272.G0RZ60"/>
    <dbReference type="GeneID" id="18254219"/>
    <dbReference type="KEGG" id="cthr:CTHT_0001810"/>
    <dbReference type="eggNOG" id="KOG1603">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2422">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008321_1_0_1"/>
    <dbReference type="OrthoDB" id="205993at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000008">
        <property type="entry name" value="Copper transport protein ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006994">
        <property type="entry name" value="TCF25/Rqc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684">
        <property type="entry name" value="NULP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684:SF0">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT TCF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04910">
        <property type="entry name" value="Tcf25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="3">
        <location>
            <begin position="788"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="635"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="850"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="635"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS23488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="869" mass="98235" checksum="4E0FBF6A6667F833" modified="2011-10-19" version="1">MATRQLRKLRKRQELLSLQNEAAEESDDEPIVERPRGSKFAGFAALGDMGGDDDEDEEERNEEEEEQMPAEKPVEQAVPAKKSKKSKKKKKKKKAKQTESPAATEEQPQGDVDEIDRVLEELKLEAQQKGAEIPGAIPAADPTEKINQLLSINFQHLKAANEMRRLFGKAMDVAESEERTEQARQQRTLPQNVDLETFLSIRGQQGYYAPGRQAKQGMFETVLRTNPFIEGKRTWPRGSALGLKMIRIEGGNNEFSFAHDKTYDELEASFFGLVQMYDPMQIVYFLHRYPYHVSSLIQCSKVARQDQNEALAADLIERALFTFGRVSLSEFRKKLEKGQARMSFYRPENRQFYLAGFNLIQKLALKGTYRTALEWAKLLLSINHDDPYGIANVLHVLAIRAREADWFIDLCKSGLLDAPFTGCYTKHTEPLAYLQLGDEDTAKSILTRNIDPRPPQIGRCIRQPPILDFLPPLLPPISLSTARFIYLDNTPSLMALLPPSILHSPDTPNFDFDPLPPPREQNIFSSPAQHLPWAEYGATITNSTTLDDIEELPESRRQEVYRQIENTPRADRVRQMAERAMAEFNLGGQLARLWPREREILARNMRRRGDQRLRLGQPEAAIVFWEVAREVERFGGEQQAPREGREAGAREAEQSRAEAAPAEETGTRAESEEAQEQQQARTRWEQWIEPLVDLIVPRPAPTENRGLPADVMMGVPGAWVEDWDDDFEGVDEFEGEDDFYGEYDDEEEEEEEQNRGNPIVGATALVLRYNGTNVSLIAAEDGSSRMSEHKYEFSVTMSCSGCSGAVERVLKKLEGVKSYEVSLDSQTAVVVADESLPYEKVLRTIAKTGKKVTAGKADGVEQSVEVPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZA7</accession>
    <name>G0RZA7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0002290</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690777.1">
        <property type="nucleotide sequence ID" value="XM_006690714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZA7"/>
    <dbReference type="GeneID" id="18254267"/>
    <dbReference type="KEGG" id="cthr:CTHT_0002290"/>
    <dbReference type="HOGENOM" id="CLU_940083_0_0_1"/>
    <dbReference type="OrthoDB" id="5226619at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="296" mass="31759" checksum="F5C3F6F795BD5E60" modified="2011-10-19" version="1">MPAACQLVRPELAEVVLRVVLRGQLNDPSLNLAGAPSPPNNCLHASSYALVSVDIANPNTITLDTAPPYGDIGFLPQSVNCSLRWVYAIGQPETTYTFESLSARDDSDSDSDDDGDWCDDDPDPEPEPTTTRGRWWRTSTSTVSAVPTTRITVTTTSTAAPTSTSTPQPPPSQGNPTRLGPPNGGPLACEDISPFGSAGIWSVTWLPDPSTPETSSLRRFGLKIALTEAVVLRNGAIEELKWEAEEWFSTDTNLLSQCSSSGVCRWALRDNVVPLAVRQALVGRRCVVGNCEGAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZH0</accession>
    <name>G0RZH0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">DNA 5'-3' helicase</fullName>
            <ecNumber evidence="19">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">CTHT_0002930</name>
    </gene>
    <organism evidence="25">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="26" key="2">
        <citation type="journal article" date="2024" name="Nat. Struct. Mol. Biol." volume="31" first="1580" last="1588">
            <title>XPD stalled on cross-linked DNA provides insight into damage verification.</title>
            <authorList>
                <person name="Kuper J."/>
                <person name="Hove T."/>
                <person name="Maidl S."/>
                <person name="Neitz H."/>
                <person name="Sauer F."/>
                <person name="Kempf M."/>
                <person name="Schroeder T."/>
                <person name="Greiter E."/>
                <person name="Hobartner C."/>
                <person name="Kisker C."/>
            </authorList>
            <dbReference type="PubMed" id="38806694"/>
            <dbReference type="DOI" id="10.1038/s41594-024-01323-5"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.10 ANGSTROMS) OF 7-780 IN COMPLEX WITH ADP AND [4FE-4S] CLUSTER</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RAD3/XPD subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="19"/>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690840.1">
        <property type="nucleotide sequence ID" value="XM_006690777.1"/>
    </dbReference>
    <dbReference type="PDB" id="8REV">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="A=7-780"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZH0"/>
    <dbReference type="EMDB" id="EMD-19109"/>
    <dbReference type="SMR" id="G0RZH0"/>
    <dbReference type="STRING" id="759272.G0RZH0"/>
    <dbReference type="GeneID" id="18254331"/>
    <dbReference type="KEGG" id="cthr:CTHT_0002930"/>
    <dbReference type="eggNOG" id="KOG1131">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011312_1_0_1"/>
    <dbReference type="OMA" id="WQTMGIL"/>
    <dbReference type="OrthoDB" id="272481at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045951">
        <property type="term" value="P:positive regulation of mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.40:FF:000001">
        <property type="entry name" value="DNA repair helicase (Rad3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.30:FF:000001">
        <property type="entry name" value="DNA repair helicase RAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000135">
        <property type="entry name" value="DNA repair helicase RAD3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000128">
        <property type="entry name" value="Putative DNA repair helicase RAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000381">
        <property type="entry name" value="TFIIH basal transcription factor complex helicase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010643">
        <property type="entry name" value="HBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001945">
        <property type="entry name" value="RAD3/XPD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06777">
        <property type="entry name" value="HBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00852">
        <property type="entry name" value="XRODRMPGMNTD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="26" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4 26" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="21" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 26" id="KW-0408">Iron</keyword>
    <keyword evidence="12 26" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="17" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 26" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 26" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="13" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="23">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="727"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="727"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EGS23598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="26">
        <source>
            <dbReference type="PDB" id="8REV"/>
        </source>
    </evidence>
    <sequence length="780" mass="89665" checksum="521B8D6EE6A59721" modified="2011-10-19" version="1">MEFMIDYMCDLKKTLDAGGNCVLEMPSGTGKTITLLSLIVAYQQHYAEHRKLIYCSRTMSEIEKALVELKALMKFRAERLGYVEEFRGLGLTSRKNLCLHPSVKREKSGTIVDARCRSLTAGFVKEKKQRGEDVDVCIYHDNLDLLEPHNLIPNGIWTLDNLLKYGEEHKQCPYFTARRMLQYCNVVIYSYHYLLDPKIAERVSRDLSSDSIVVFDEAHNIDNVCIEALSTDITEESLRRATRGAQNLENRINEMKETDQQKLQDEYEKLVEGLRGNDDGTREDSFMTSPVLPQDLLKEAVPGNIRRAEHFVAFLRRFIEYLKTRMKVRQVISETPPSFLAHLKEYTFIEKKPLRWCAERLTSLVRTLELTNIEDYHALQEVATFATLVATYEKGFLLILEPYESDTAEVPNPVLHFCCLDAAIAIKPVFDKFRNVIITSGTISPLEMYPKMLNFTTVVQESYSMTLARRSFLPLIVTRGSDQASISTGFQVRNEPSVVRNYGNLLTEFAKITPDGMVVFFPSYLYMESIISMWQGMGILDEVWKYKLILVETPDAQETSLALETYRTACCNGRGAVLLCVARGKVSEGIDFDHQYGRTVLCIGVPFQYTESRILKARLEFLRETYRIRENDFLSFDAMRHAAQCLGRVLRGKDDYGLMVLADRRFQKKRNQLPKWIAQALLDADTNLSTDMAVSSARRFLKTMAQPFKAKDQEGISTWSLEDLKRHQQKMDEERMKELEAQREKESAPAVERPADQGRESDYEVDEEEEREMMALDVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZL0</accession>
    <name>G0RZL0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small nuclear ribonucleoprotein Sm D1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">snRNP core protein D1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0003330</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="12 13 14" key="2">
        <citation type="journal article" date="2025" name="Cell Res." volume="35" first="296" last="308">
            <title>Structural insights into spliceosome fidelity: DHX35-GPATCH1- mediated rejection of aberrant splicing substrates.</title>
            <authorList>
                <person name="Li Y."/>
                <person name="Fischer P."/>
                <person name="Wang M."/>
                <person name="Zhou Q."/>
                <person name="Song A."/>
                <person name="Yuan R."/>
                <person name="Meng W."/>
                <person name="Chen F.X."/>
                <person name="Luhrmann R."/>
                <person name="Lau B."/>
                <person name="Hurt E."/>
                <person name="Cheng J."/>
            </authorList>
            <dbReference type="PubMed" id="40016598"/>
            <dbReference type="DOI" id="10.1038/s41422-025-01084-w"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.80 ANGSTROMS)</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in splicing regulation. Facilitates post-transcriptional gene silencing (PTGS) by limiting the degradation of transgene aberrant RNAs by the RNA quality control (RQC) machinery, thus favoring their entry into cytoplasmic siRNA bodies where they can trigger PTGS. Does not participate in the production of small RNAs.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690880.1">
        <property type="nucleotide sequence ID" value="XM_006690817.1"/>
    </dbReference>
    <dbReference type="PDB" id="9L5R">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="d/o=1-118"/>
    </dbReference>
    <dbReference type="PDB" id="9L5S">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="o=1-118"/>
    </dbReference>
    <dbReference type="PDB" id="9L5T">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.50 A"/>
        <property type="chains" value="o=1-118"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZL0"/>
    <dbReference type="EMDB" id="EMD-62841"/>
    <dbReference type="EMDB" id="EMD-62842"/>
    <dbReference type="EMDB" id="EMD-62843"/>
    <dbReference type="SMR" id="G0RZL0"/>
    <dbReference type="STRING" id="759272.G0RZL0"/>
    <dbReference type="GeneID" id="18254371"/>
    <dbReference type="KEGG" id="cthr:CTHT_0003330"/>
    <dbReference type="eggNOG" id="KOG3428">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123956_3_0_1"/>
    <dbReference type="OMA" id="TFLMKLT"/>
    <dbReference type="OrthoDB" id="9626941at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097525">
        <property type="term" value="C:spliceosomal snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01724">
        <property type="entry name" value="Sm_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000008">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034102">
        <property type="entry name" value="Sm_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="12 13 14" id="KW-0002">3D-structure</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7 10" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="9">
        <location>
            <begin position="2"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="80"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS23638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="9L5R"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="9L5S"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="9L5T"/>
        </source>
    </evidence>
    <sequence length="118" mass="13007" checksum="D22DBA0A2BCE72BF" modified="2011-10-19" version="1">MKLVRFLMKCANETVTIELKNGAIVHGTIASVTPKMDTALRNVRYTPKGEEPYSVESLTVRGNTIRYYILPDSLPLDTLLIDDAPKPKNKARKEADRGRGRGRGRGGRGGRGGRARGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZN0</accession>
    <name>G0RZN0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fanconi-associated nuclease</fullName>
            <ecNumber evidence="8">3.1.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0003540</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.</text>
            <dbReference type="EC" id="3.1.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the FAN1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.1" evidence="8"/>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690900.1">
        <property type="nucleotide sequence ID" value="XM_006690837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZN0"/>
    <dbReference type="STRING" id="759272.G0RZN0"/>
    <dbReference type="GeneID" id="18254392"/>
    <dbReference type="KEGG" id="cthr:CTHT_0003540"/>
    <dbReference type="eggNOG" id="KOG2143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005116_1_0_1"/>
    <dbReference type="OMA" id="ECRVESM"/>
    <dbReference type="OrthoDB" id="76364at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070336">
        <property type="term" value="F:flap-structured DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004528">
        <property type="term" value="F:phosphodiesterase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22326">
        <property type="entry name" value="FAN1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1350.10:FF:000009">
        <property type="entry name" value="Fanconi-associated nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033315">
        <property type="entry name" value="Fan1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049132">
        <property type="entry name" value="FAN1-like_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049126">
        <property type="entry name" value="FAN1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014883">
        <property type="entry name" value="VRR_NUC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749">
        <property type="entry name" value="FANCONI-ASSOCIATED NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749:SF4">
        <property type="entry name" value="FANCONI-ASSOCIATED NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21170">
        <property type="entry name" value="FAN1_TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08774">
        <property type="entry name" value="VRR_NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00990">
        <property type="entry name" value="VRR_NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VRR-NUC" evidence="10">
        <location>
            <begin position="689"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS23658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="803" mass="92315" checksum="8D0CFF633F31BDB6" modified="2011-10-19" version="1">MDRYIRRNKPHHEAGQSDPAEHRASKKPRLGNDQRDDEGANESLNVSPTSDSWDDEPTVLGVYASAEEVIDEPPVTVATAFESSLPTVATGTDTNDEYEMLRVSQAAQDDEVPSKHDGNRWTKGRSSIYVDAFNLALDTVLNEESHLFDDKEKHVFEQWRSIGYEAQYMLVSLPVLLLQPDIDSEIELQEWSLGDSFTFADDSDSYIQTVEEAAALLSMDELKILAKEARVQGKNKGDLLKAFCRASAQQTGLLALGIKQFGANDSSSDGVTMMDHRNRNAHFLQKILSITGPLIRLSAPVFKLFERVHLVFFRSTEWTEKSLTTILLAKMAKRNYPEYIVCRSTNIFPSRRHLLDFELSMRKDFEVDQALESRGSGEEGFRKVIYIFESIASRWRELIREENYRENHVYEFGEGGYLRRFSPGHAYTRIAHKAAHALGRLHKYWEEHQLLTELLNQRLFHLARRGAWYQRKALLEERYMWETDPDPVSPDPEVRKKHWQRIAVTTCETALEDRDCHLIYHYDLQKRLLKLEKKLRIPRRLQHDFGHVRLHEPEIHVVYGIQLVRREPDIKDKPIRTSGKTMWLDELGAPDKNGNPLHVRVEEMCLSHYRSKGWKGYHSEGGILRTLFAYLFFDIMFVYVPNVFQTACQTCPLDLFTDTFYTTRASQINHRLVEISNGEGPRIVREVHSREYKRRTCVIGLNWDFDIDDLVELVSCFDGEALAAVCKVIAQEYRSRVSGVPDLILWRPATDGSPKTGEVMFAEVKSANDRLSDAQRLWINVLIGAGIRVALCNAVATEVHTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZV9</accession>
    <name>G0RZV9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0004390</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690979.1">
        <property type="nucleotide sequence ID" value="XM_006690916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZV9"/>
    <dbReference type="GeneID" id="18254477"/>
    <dbReference type="KEGG" id="cthr:CTHT_0004390"/>
    <dbReference type="eggNOG" id="ENOG502QSKG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_0_0_1"/>
    <dbReference type="OMA" id="TSAMHEW"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="39841" checksum="ABDC17E560F6D17D" modified="2011-10-19" version="1">MTKEAEEKKEQQQPQQPVDVPGLLPSSHWASIPVENEDDDTDSLCSSKASSTTSVRDSILEYRRLYGRTYHHEIGDAESWIPNDDKHLDSMEILHYASILALGNKLFLAPLDKDRIRKVLDVGTGSGLWVIDFADQFPNAQVTGTDITPIQPTWVPPNVSFELDDANQDWTWSSNTFDFIRTRYMIGCISDWKKFYENAFRCLKPGGYFEHEESSGKWYSDTGGIPDESPIAQGLKAFRAAGDKTGRTFQVVEEGLQKKYMEEVGFVDIVVKDVRVPLGTWPEDPEQKQIGMLVSEAILGDLEGYLLYMLVNILGWSEDGARALAAHARAQFRKPGVNPYWIRRVVYGRKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0S016</accession>
    <name>G0S016_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0008400</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691368.1">
        <property type="nucleotide sequence ID" value="XM_006691305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S016"/>
    <dbReference type="STRING" id="759272.G0S016"/>
    <dbReference type="GeneID" id="18254878"/>
    <dbReference type="KEGG" id="cthr:CTHT_0008400"/>
    <dbReference type="eggNOG" id="KOG1331">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029501_2_0_1"/>
    <dbReference type="OMA" id="VHEVYQQ"/>
    <dbReference type="OrthoDB" id="271595at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106335">
        <property type="term" value="F:tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051422">
        <property type="entry name" value="AlkB_tRNA_MeTrf/Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069:SF21">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="71"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="228"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS23177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="330" mass="35355" checksum="51D1BB7D286FFB03" modified="2011-10-19" version="1">MTSSALPSQSAAEAAAKLAAAADAEAEAYESTHVHGVYEAIASHFSATRYKPWPAVASFLRALPPGAVGFDVGCGNGKYLGVNPDVVMIGSDRSPSLIALAKSRVKQIQSVRPYPNQQNSVARTGGEITSSPNNSTPAVGTDVLVADGLLLPFRERTADFAICVAVIHHMSTRARRQEAIRQLLRCLKLDGQVLLYVWALEQGTSRRGWDEGSEQDLLVPWVLKNNQPNTQKQQQHQKKGSSQKNQAENALTGSAGMSRSPPTPGAPPPAEPAATAPGQSDPVFQRYYHLYRKGELEEDVLAAGGVIISSGYEKDNWWVVAANKGVHHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0S034</accession>
    <name>G0S034_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">O-acetylhomoserine aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="12">2.5.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0008580</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-acetyl-L-homoserine + hydrogen sulfide = L-homocysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:27822"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57716"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="2.5.1.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-acetyl-L-homoserine + methanethiol = L-methionine + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10048"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16007"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57716"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="EC" id="2.5.1.49"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homocysteine from O-acetyl-L-homoserine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.49" evidence="12"/>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691386.1">
        <property type="nucleotide sequence ID" value="XM_006691323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S034"/>
    <dbReference type="STRING" id="759272.G0S034"/>
    <dbReference type="GeneID" id="18254896"/>
    <dbReference type="KEGG" id="cthr:CTHT_0008580"/>
    <dbReference type="eggNOG" id="KOG0053">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018986_4_0_1"/>
    <dbReference type="OMA" id="NAFQIIQ"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003961">
        <property type="term" value="F:O-acetylhomoserine aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071269">
        <property type="term" value="P:L-homocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000083">
        <property type="entry name" value="O-acetylhomoserine sulfhydrylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000035">
        <property type="entry name" value="O-succinylhomoserine sulfhydrylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797">
        <property type="entry name" value="HOMOCYSTEINE/CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797:SF2">
        <property type="entry name" value="HOMOCYSTEINE_CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7 13 14" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="13">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS23195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="439" mass="47190" checksum="9DBEA0109DE37776" modified="2011-10-19" version="1">MSQQNFKFETLQLHAGQEPDPTTNARAVPIYATTSYVFNDSAHGARLFGLKEFGNIYSRIMNPTVDVFEKRVAALEGGVAAVAASSGQAAQFMAIAALAHAGDNIVATSNLYGGTYNQFKILFKRLGITTKFVNGDKPEDIAAAIDDKTKAVYIESIGNPRYNVPDFEAIAKVAHDAGIPLVVDNTFGAGGYFVRPIEHGADIVVHSATKWIGGHGTTIAGVIVDSGKFDWGKHGDKFPQMVEPSEGYHGLKFWETFGPITYAIRVRVELLRDLGACLNPFGAQQLLLGLETLSLRAERHAQNALALAHWLQQSPYVAWVSYPGLESHPSHATAKKYLKRGFGGVLSIGVKGGGAAGSRVVDGLKLVSNLANVGDAKTLAIHPWTTTHEQLTDEEKISSGVTEDLIRISVGLEHIDDIIADFEQSFKAAAEAGYLEAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0S073</accession>
    <name>G0S073_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0009000</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691425.1">
        <property type="nucleotide sequence ID" value="XM_006691362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S073"/>
    <dbReference type="STRING" id="759272.G0S073"/>
    <dbReference type="GeneID" id="18254938"/>
    <dbReference type="KEGG" id="cthr:CTHT_0009000"/>
    <dbReference type="eggNOG" id="KOG2483">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017046_0_0_1"/>
    <dbReference type="OMA" id="MQHKQLS"/>
    <dbReference type="OrthoDB" id="8964853at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040112">
        <property type="entry name" value="WetA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22934">
        <property type="entry name" value="PROTEIN ESC1/WETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22934:SF23">
        <property type="entry name" value="ZF-C3H1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="276"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="430" mass="47487" checksum="43B18F1944DC5A4B" modified="2011-10-19" version="1">MGVLSPPTSGFQASPADKTPSPTSQSNLLPQPLVSPTHSNGSMSVASIVSPTNTGNMGRFDRPQSLDSGPNSATFLNGDPAESLSRRESVDSRINQGFNDMRLGNSPYASHNQSTTSIHTTLQQQRNPRSGLDSLSIHRISNGYQPSAERNPEGHHPKTMRIAPAITGPATSTIARAAEPTKGQAWAFPEEEIHRLPSTASQSLIDSRRSSIAESLASSQFTTESRLPPGQRRLEESGSGFSNVHHHSLQHKQVGDLRNGESSSQTSSQPYSRTPELRISHKLAERKRRTEMKELFEQLRDLMPQERGSKASKWEILTKAIQEHHRQNELIRQLQAHAATQQAEIEMLKRELHECRMNSRPPQPHQPAPDHHHPYGTDQYGRPRQPELPPLRSALQGASAPPVGGPDSMTGVQYEPPRVNGYRPPEPTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0H0</accession>
    <name>G0S0H0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acid phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0009990</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691522.1">
        <property type="nucleotide sequence ID" value="XM_006691459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0H0"/>
    <dbReference type="STRING" id="759272.G0S0H0"/>
    <dbReference type="GeneID" id="18255037"/>
    <dbReference type="KEGG" id="cthr:CTHT_0009990"/>
    <dbReference type="eggNOG" id="KOG3030">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021458_2_0_1"/>
    <dbReference type="OMA" id="WNAGWMG"/>
    <dbReference type="OrthoDB" id="8907274at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF154">
        <property type="entry name" value="PAP2 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G09730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="8">
        <location>
            <begin position="120"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="260"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="400"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="407"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="448"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS23331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="466" mass="51277" checksum="364496DB6AB57F83" modified="2011-10-19" version="1">MDNFDLPRGSVHRPGRTSWVVGASYVFDWVVLAAFGAVGYVLGHITPNKRPFSLDDRNIAFPFTEEETVPAWLATIISVFGPIVFITIISLVFVPGATVPRGTPSRLIWQRRLWELHIGLLGLALSMCASWFITNAMKNLFGKPRPDLLSRCQPDLENLNKYLISATKTFGDIATMAGKLVDPSICKNPDKSKLDDGFRSYPSGHSSSAAAGLIYLSLFIASKFAITIPFVPPSGATDAAAFTAFPSRTRLPNIKVSAPDSYEMTSRDPTTHTNSSLESNPGPKGVSRHNQTIFAVRRQAAAPPIYLLVLAVLPFFASVYIAGSRWWDFRHHAFDILFGYGIGTISAFFAFYYYHLPISTGAGWAWGPRSAEKAFWAGVGSSSYATDHLRGEYRRGDEEEALPVVATHEHEQRDRRDAERDPAPFVTRDTGLSTASSVAMSMPGSRKPTLELDSRETSYRGAGDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0H7</accession>
    <name>G0S0H7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Pre-mRNA splicing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0010060</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="15 16 17" key="2">
        <citation type="journal article" date="2025" name="Cell Res." volume="35" first="296" last="308">
            <title>Structural insights into spliceosome fidelity: DHX35-GPATCH1- mediated rejection of aberrant splicing substrates.</title>
            <authorList>
                <person name="Li Y."/>
                <person name="Fischer P."/>
                <person name="Wang M."/>
                <person name="Zhou Q."/>
                <person name="Song A."/>
                <person name="Yuan R."/>
                <person name="Meng W."/>
                <person name="Chen F.X."/>
                <person name="Luhrmann R."/>
                <person name="Lau B."/>
                <person name="Hurt E."/>
                <person name="Cheng J."/>
            </authorList>
            <dbReference type="PubMed" id="40016598"/>
            <dbReference type="DOI" id="10.1038/s41422-025-01084-w"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.80 ANGSTROMS) IN COMPLEX WITH 1D-MYO-INOSITOL HEXAKISPHOSPHATE</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly and initiation of the DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691529.1">
        <property type="nucleotide sequence ID" value="XM_006691466.1"/>
    </dbReference>
    <dbReference type="PDB" id="9L5R">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="J=1-687"/>
    </dbReference>
    <dbReference type="PDB" id="9L5S">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="J=1-687"/>
    </dbReference>
    <dbReference type="PDB" id="9L5T">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.50 A"/>
        <property type="chains" value="J=1-687"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0H7"/>
    <dbReference type="EMDB" id="EMD-62841"/>
    <dbReference type="EMDB" id="EMD-62842"/>
    <dbReference type="EMDB" id="EMD-62843"/>
    <dbReference type="SMR" id="G0S0H7"/>
    <dbReference type="STRING" id="759272.G0S0H7"/>
    <dbReference type="GeneID" id="18255044"/>
    <dbReference type="KEGG" id="cthr:CTHT_0010060"/>
    <dbReference type="eggNOG" id="KOG1915">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011554_1_0_1"/>
    <dbReference type="OMA" id="HIKVWIS"/>
    <dbReference type="OrthoDB" id="541719at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000048">
        <property type="entry name" value="Cell cycle control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000306">
        <property type="entry name" value="Cell cycle control protein cwf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000269">
        <property type="entry name" value="Crooked neck pre-mRNA-splicing factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059164">
        <property type="entry name" value="HAT_PRP39_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF3">
        <property type="entry name" value="CROOKED NECK-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23241">
        <property type="entry name" value="HAT_PRP39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23240">
        <property type="entry name" value="HAT_PRP39_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="15 16 17" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="10" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="12">
        <location>
            <begin position="60"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="11">
        <location>
            <begin position="380"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>1D-myo-inositol hexakisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>1D-myo-inositol hexakisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>1D-myo-inositol hexakisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>1D-myo-inositol hexakisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>1D-myo-inositol hexakisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS23338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="9L5R"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="9L5S"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PDB" id="9L5T"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="687" mass="82064" checksum="BCDC099C0CE4A091" modified="2011-10-19" version="1">MESSRGPPRVKNKAPAPIQISAEQLLREAVDRQETIIHKPTQRFADLEELKEYQGRKRREFEDYIRRNRLRLQNWFQYAQWELEQKEFARARSIFERALDVHPNNTQLWIRYIEAELKNRNINHARNLLDRAVTRLPRVSKLWYKYVYVMEMLGDIPGTRQVFDRWMKWEPDEDAWNAYIKLEKRYGEYERARQIFAAYTQVHPEPRTWLKWAKFEEEFGTADMVRDVFQSAIQYIAETLGDDAVDERLFIAFARFETRQKEYERARAIYKFGLDNLPRSRSMQLHAQYTTFEKQFGDKEGVEDVVLTKRRRLYEEQVKENPKNYDVWFDFARLEEMGGDPDRVREVYERAIAQVPPTQEKRHWRRYIFLFLFYAIWEEKDAKNIERARAIYDTCLNLIPHKKFTFAKVWIAKAHFEIRQGNLTAARKTLGRAIGMCPKDKLFREYIAIEQKLYEFDRCRTLYEKHALFNPANCQTWIRWAELERGLDDLDRTRAIFEVAISQPVLDMPEVVWKAYIDFEEEEGEYERARALYERLLQKADHPKVWISYAQFEINIPDTETEAQAAEGEEIPVSEAAKARARGVFERALKSMKERDLKAERVALLRAWLEFERTHGAAEDVERIRRQMPREVKKKRRIDEDTWEEYVDYVFPADEQQTKNLSNLLAMAKQWKEKTGGGIMGLGAGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0J2</accession>
    <name>G0S0J2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <ecNumber evidence="3 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0010210</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="3 7"/>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691544.1">
        <property type="nucleotide sequence ID" value="XM_006691481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0J2"/>
    <dbReference type="STRING" id="759272.G0S0J2"/>
    <dbReference type="GeneID" id="18255059"/>
    <dbReference type="KEGG" id="cthr:CTHT_0010210"/>
    <dbReference type="eggNOG" id="KOG3243">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089358_2_0_1"/>
    <dbReference type="OMA" id="CQGVTQG"/>
    <dbReference type="OrthoDB" id="2965at2759"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.960:FF:000005">
        <property type="entry name" value="6,7-dimethyl-8-ribityllumazine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="entry name" value="Lumazine/riboflavin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058:SF0">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE DMRL SYNTHASE LUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="Lumazine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS23353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="206" mass="21470" checksum="F6EDA19F94AE52F5" modified="2011-10-19" version="1">MHNKGPAPQKHDGSSLRIGIVHARWNDDIIKALLDGTKAKLRECGVHESNIVIQSVPGSWELPIAVQRLYSASQVQSSSAGIGSSAGDLLGGSASDLLSSQLPTAATGPSTGSFDAIIAIGVLIKGETMHFEYIAESVAQGLMRVGLDTGVPVIFGVLTVLNDEQAKARAGLIPGSHNHGEDWGLAAVEMGVKRRAWATGKIEMGA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2025-02-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1P8</accession>
    <name>AHP1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peroxiredoxin AHP1</fullName>
            <shortName>Prx</shortName>
            <ecNumber evidence="1">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Alkyl hydroperoxide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">AHP1</name>
        <name type="ORF">CTHT_0014370</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="7 8 9" key="2">
        <citation type="journal article" date="2022" name="EMBO J." volume="41" first="e111318" last="e111318">
            <title>E2/E3-independent ubiquitin-like protein conjugation by Urm1 is directly coupled to cysteine persulfidation.</title>
            <authorList>
                <person name="Ravichandran K.E."/>
                <person name="Kaduhr L."/>
                <person name="Skupien-Rabian B."/>
                <person name="Shvetsova E."/>
                <person name="Sokolowski M."/>
                <person name="Krutyholowa R.C."/>
                <person name="Kwasna D."/>
                <person name="Brachmann C."/>
                <person name="Lin S."/>
                <person name="Guzman Perez S."/>
                <person name="Wilk P."/>
                <person name="Kosters M."/>
                <person name="Grudnik P."/>
                <person name="Jankowska U."/>
                <person name="Leidel S.A."/>
                <person name="Schaffrath R."/>
                <person name="Glatt S."/>
            </authorList>
            <dbReference type="PubMed" id="36102610"/>
            <dbReference type="DOI" id="10.15252/embj.2022111318"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.10 ANGSTROMS) IN COMPLEX WITH URM1</scope>
        <scope>SUBUNIT</scope>
        <scope>DISULFIDE BONDS</scope>
        <scope>URMYLATION AT LYS-44; LYS-63; LYS-99; LYS-141; LYS-156 AND LYS-171</scope>
        <scope>SULFHYDRATION AT CYS-60</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Preferentially eliminates organic peroxides rather than hydrogen peroxide. Relays alkyl hydroperoxides as a signal to the transcription factor CAD1/YAP2 by inducing the formation of intramolecular disulfide bonds in CAD1, which causes its nuclear accumulation and activation. Involved in cellular Mn(2+) homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer; disulfide-linked, upon oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="3">Conjugated to URM1, a ubiquitin-like protein, in response to oxidative stresses. The attachment of URM1 to lysine residues exclusively depends on the presence of a peroxidatic cysteine in the target protein, with low specificity for the particular residue, motif, or structural context at which urmylation can occur. The URM1-conjugation reaction is mechanistically and directly coupled to the process of cysteine persulfidation, transferring the sulfur atom of the URM1 thiocarboxyl group to redox-active cysteine residues in the target protein if it is exposed to oxidative conditions.</text>
    </comment>
    <comment type="PTM">
        <text evidence="5">Persulfidated on specific redox-active cysteine residues. Persulfidation (also called protein S-sulfhydration) may provide a molecular mechanism that enables cells to protect vulnerable cysteine residues from reactive oxygen species (ROS) under stress conditions.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this typical 2-Cys Prx, C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="1"/>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691950.1">
        <property type="nucleotide sequence ID" value="XM_006691887.1"/>
    </dbReference>
    <dbReference type="PDB" id="7Q5N">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.50 A"/>
        <property type="chains" value="A/B/C/D/E/F=1-172"/>
    </dbReference>
    <dbReference type="PDB" id="7Q68">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.75 A"/>
        <property type="chains" value="A=1-172"/>
    </dbReference>
    <dbReference type="PDB" id="7Q69">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.85 A"/>
        <property type="chains" value="A/B/C/D=1-172"/>
    </dbReference>
    <dbReference type="PDB" id="7Q6A">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.10 A"/>
        <property type="chains" value="A/B=1-172"/>
    </dbReference>
    <dbReference type="PDBsum" id="7Q5N"/>
    <dbReference type="PDBsum" id="7Q68"/>
    <dbReference type="PDBsum" id="7Q69"/>
    <dbReference type="PDBsum" id="7Q6A"/>
    <dbReference type="AlphaFoldDB" id="G0S1P8"/>
    <dbReference type="SMR" id="G0S1P8"/>
    <dbReference type="STRING" id="759272.G0S1P8"/>
    <dbReference type="GeneID" id="18255475"/>
    <dbReference type="KEGG" id="cthr:CTHT_0014370"/>
    <dbReference type="eggNOG" id="KOG0541">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072440_1_1_1"/>
    <dbReference type="OMA" id="FIRTKDQ"/>
    <dbReference type="OrthoDB" id="195498at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430:SF16">
        <property type="entry name" value="PEROXIREDOXIN-5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0049">Antioxidant</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-1017">Isopeptide bond</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0575">Peroxidase</keyword>
    <keyword id="KW-0676">Redox-active center</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0832">Ubl conjugation</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000461632" description="Peroxiredoxin AHP1">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="4"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="1">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="modified residue" description="Cysteine persulfide" evidence="3">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Interchain (with C-60); in linked form" evidence="3 8">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Interchain (with C-30); in linked form" evidence="3 8">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in URM1)" evidence="3">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in URM1)" evidence="3">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in URM1)" evidence="3">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in URM1)" evidence="3">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in URM1)" evidence="3">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in URM1)" evidence="3">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="strand" evidence="11">
        <location>
            <begin position="15"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="strand" evidence="10">
        <location>
            <begin position="27"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="strand" evidence="11">
        <location>
            <begin position="34"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="38"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="strand" evidence="11">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="58"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="64"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="72"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="strand" evidence="11">
        <location>
            <begin position="82"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="strand" evidence="11">
        <location>
            <begin position="105"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="114"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="117"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="strand" evidence="11">
        <location>
            <begin position="132"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="strand" evidence="11">
        <location>
            <begin position="141"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="turn" evidence="11">
        <location>
            <begin position="155"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="159"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P38013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="36102610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000305" key="5">
        <source>
            <dbReference type="PubMed" id="36102610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="7">
        <source>
            <dbReference type="PDB" id="7Q5N"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="8">
        <source>
            <dbReference type="PDB" id="7Q68"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="9">
        <source>
            <dbReference type="PDB" id="7Q69"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="7Q5N"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="7Q6A"/>
        </source>
    </evidence>
    <sequence length="172" mass="18000" checksum="17C45823EDF7C8C9" modified="2011-10-19" version="1">MAPLQPGDSFPANVVFSYIPPTGSLDLTVCGRPIEYNASEALAKGTSVLVAVPGAFTPTCQEKHVTGFIAKLDQLRQAGVDRVLFIASNDAFVMSAWGKANGIKDESILFLSDSDTAFSSSIGWANAGRTGRYAIVVKDGKVVYAAVDTVRGSTEKSGVDAVLTVLGNQGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1Z5</accession>
    <name>G0S1Z5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0015400</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS23055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692047.1">
        <property type="nucleotide sequence ID" value="XM_006691984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1Z5"/>
    <dbReference type="STRING" id="759272.G0S1Z5"/>
    <dbReference type="GeneID" id="18255578"/>
    <dbReference type="KEGG" id="cthr:CTHT_0015400"/>
    <dbReference type="eggNOG" id="KOG0437">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004174_1_1_1"/>
    <dbReference type="OMA" id="KFIEWQF"/>
    <dbReference type="OrthoDB" id="10249672at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000001">
        <property type="entry name" value="Leucine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004493">
        <property type="entry name" value="Leu-tRNA-synth_Ia_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055416">
        <property type="entry name" value="RBD_LARS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00395">
        <property type="entry name" value="leuS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794:SF1">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24810">
        <property type="entry name" value="RBD_LARS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="67"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="214"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="12">
        <location>
            <begin position="833"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine--tRNA ligase RagD-binding" evidence="13">
        <location>
            <begin position="982"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF24810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS23055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1121" mass="127173" checksum="CD7216675846D4E7" modified="2011-10-19" version="1">MADTTVPKALEALTISKTKELKGTEKRDTLIAIEKKYQKKWEEEHVFEVDAPSIDEFPLESISPEELREKFPKFFGTIAYPYMNGRLHAGHAFSFSKIEFFTGFARMQGKRCLFPLGYHCTGLPIKASADKLAKEVEMFGADFSGYKPEEEEEPAPAEPAPKGQKEDLTKFSAKKGKAAAKTVKAKYQFQILQSVGIPLEEIHRFADPQYWLKYFPPACKQDLTNFGARIDWRRQFVTTDANPYYDAFVRWQMVRLKELEKIKFGKRYTIYSIKDGQPCMDHDRSEGEGVLPQEYTALKLKVIEWAPKAAEAIKGKLPEGASVYLCPATLRPETMYGQVCCFVGPSLTYGVYKARENEYFVITERAARNMAFQSIFEKDGIPEKAADLQGSDLIGTLVNAPLSFHREVRVLPMETVLATKGTGVVTSVPSDSPDDYATVTELAKKPDYYGIKKEWAELEIIPIIQTPTSDLIAPYLVKKLKINSPKDTKQLAEAKELAYKEGYYQGVMKVGDFAGEKVEVAKPKVREQLIKNGDAFPYSEPESKVVSRSGDECTVALLDQWYIDYGEDSWRQQALEYVENKDGKGLECYSPDTQHAFKGVLAWLKQWACARTYGLGSKLPWDPQFLVESLSDSTIYMAYYTLVPWLHKDLFGREKGKGNIAPEQMIDEVWDYVFCRTEWSDDLVEKSGIPKETLQGMRRDFQYFYPLDLRVSGKDLIPNHLTFFLYNHIALFPREYWPKSIRANGHLQLNGEKMSKSTGNFMTLDDVVRKYGADAARVALADAGDGITDSNFVEDVADNTILRFYTNKEWIEEIIKDDKLRTGPLNDFQDALFDNEMNALVNEAKKYYEETSYKLALKAAHYDFLNARDTYREACNAAGIPLHKDLVFKYIRLQALILTPIAPHWADYVWREILGEKESIQFARWPEVPAADPALTAAREYVRTTSSNINSAEAAQLKKMAKGRQSDFDPKKPKKLTIFMTESFPAWQAKYIELLKKVWDPATNTQKIEDKELNGRIAKMGEMKKAMPFVQALKKRLRDGEPAETVLERKLAFDEKKTLLAMVPGLKRTAGLVAVQILAVTEGSKVGIDLTNNNVEVEVKAPVAESALPGQPSFHFENVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G0S213</accession>
    <name>G0S213_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0015590</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS23073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692065.1">
        <property type="nucleotide sequence ID" value="XM_006692002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S213"/>
    <dbReference type="STRING" id="759272.G0S213"/>
    <dbReference type="GeneID" id="18255597"/>
    <dbReference type="KEGG" id="cthr:CTHT_0015590"/>
    <dbReference type="eggNOG" id="ENOG502SAW3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_304824_0_0_1"/>
    <dbReference type="OrthoDB" id="5369448at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="646"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="765"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="647"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="769"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="974" mass="107643" checksum="9B863B14EAD71829" modified="2011-10-19" version="1">MPGKVPNLDLDPSVRVDPTFECAVGLMVDGISTTPKRMSSSARGGREGIFKAGEGTSRKPMEAAVVDPETMPQAETHADSINGLHEAIDCAYESLHPHIAQRKGSLCAEALVQEAARVVHDKTEKYTAQANTGRCDDGRSLEHSSLNTGSQDGREANRVRRHPQYRSTSSEDTGSSPNEHDDDVFSDRSAQSSPCSLDAKYEVTDSCDKTATGSPQQQDELLNSSLHRESFTSSPKESTRRTSGYSGISDLHAMTSSPTPSISNGSSPLPLSNKKRRTNGLAARITSPVAPVQYSPKGKSTPPRFRSRKEAPLVLLHVTLLPLRWVWGDVVNNMDAIVTAHNARLKERVMANLEAEGKPMIGKLEPSDGLKTLRDVWRELQDRVGDTVLERGILIPHPQNDYEILEERLLEALELPVKRRARILECGHYLGPSNVDDDSEDDPDFDDYDDDYSRREKHGKRHWCSLCRSEIKFEELGPNKAFRIKVYASNGLMKAGAWEACWKEMERVDVEIEPLVDIPMQNELEKLAMAQFELEDHHRREEEVALGIGFEQHARDANESFHLRSDTPVMNIRGQSAAGQLSSGEAMPTPSPVSVLPAAEELAALRTKTPMIDISGGYRHHDEELLHEIHGETDLVAPRNEAFNPYQQPQQRAQSRSQASSAAMVDSTVCRPRSQHADVHQSDPYRQPQPPRQRPHSSRKMFVLDENTSFVDLLMEAFKVLLRDPKNVAIIVLSLFLVVLVKQPRRPGSGLEVVMPGRAPQVIQEPMTSVQSQQQPQQPQVQPVPQVLDGPGAQMSQLPQEQSQAMALQVQPQGLEPIVASSIVAESPFDPRVGSASDLSQSPKKERMQIEGTPFSQLSQKVQAAELETNGRARDAKTVALASSNSVIDPLVCHWLEHPQCLKISPFDDCISSPINALNLYDDHCFDSEPTLTISVSSTDPSVFVSGPMVTACKTVRIYETVTETVRVSVITQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2D4</accession>
    <name>G0S2D4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0016840</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692186.1">
        <property type="nucleotide sequence ID" value="XM_006692123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2D4"/>
    <dbReference type="GeneID" id="18255722"/>
    <dbReference type="KEGG" id="cthr:CTHT_0016840"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="OMA" id="EYIPGIW"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000409">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000511">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF47">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="471"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="564"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="596"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="207"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="112"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS22167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="648" mass="71996" checksum="83535BACBF236FA3" modified="2011-10-19" version="1">MTPSSLDTPEPVPPDLSGWPGWSRGDDKFDDGLVLELCRLWVFKGAVEEEARVQHLDSWTWGKWSQKHVKRRMRYQNAWIGQKLESTGLELPGPVVRLCLAHIWGRPGEEGNKELWGRSRNLDSSPLDHPKRHKNSFDQTPDNSTQLHETNMSGSQEKVAVETVEAADSDRGTKESGIASPAPINPDDFGFTPQEQKKIIRQIDRRLVLTVGALYCISLMDRTNLGAAMIAGMGTDLKLIGNRYSVITLVFFVTYVIFQPPSTVICRKIGPRLHMSVITVLWGGVMIGMGFIPTWGGMTAMRLILGVLEAGFFPSCVYLLSTWYTRYEVGVRNSIFYLCGSAASACAGILAYGLMQMAGLANLNGWRWIFIIEGILTVLLGTAGYWLLVDFPDSKRKTWAFLGERERAWICARVQQDRGDVKPQPFSIIKYLRPALDIKIWAYAMIFFNTTTVTYALAYFMPIILQYNMGFSVGAAQCLVAPPYVFGGIVTYLTGLAGDKFRLRGPIIIFNCILVLIGLPIVGWATSPGVRYFGIFLMTAGGNANVPAAMSYQANNIRGQWKRALCSATFVSFGGIGGIAGSLVFRSQDSPHYRPGLYACFATTGLNILLVCLLSLYFRHANAKADRGEVELECDGDDDYEPGFRYTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2K3</accession>
    <name>G0S2K3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">YggU-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0017530</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0235 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692255.1">
        <property type="nucleotide sequence ID" value="XM_006692192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2K3"/>
    <dbReference type="STRING" id="759272.G0S2K3"/>
    <dbReference type="GeneID" id="18255791"/>
    <dbReference type="KEGG" id="cthr:CTHT_0017530"/>
    <dbReference type="eggNOG" id="KOG3276">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130694_1_0_1"/>
    <dbReference type="OMA" id="TIYIHCH"/>
    <dbReference type="OrthoDB" id="244097at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1200.10">
        <property type="entry name" value="YggU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00634">
        <property type="entry name" value="UPF0235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003746">
        <property type="entry name" value="DUF167"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036591">
        <property type="entry name" value="YggU-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00251">
        <property type="entry name" value="DUF167 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13420">
        <property type="entry name" value="UPF0235 PROTEIN C15ORF40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13420:SF7">
        <property type="entry name" value="UPF0235 PROTEIN C15ORF40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02594">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01152">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69786">
        <property type="entry name" value="YggU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="12914" checksum="1BD9BEE037387A2E" modified="2011-10-19" version="1">MSSARAMWYVAGTKKSPNGTLYLNCNVKPGASKQREGIASVGDDAVEICVAAQAREGEANKAVIKVLSEVLDLPKSDLQITQGLKSRNKTVAVSGGWINSGEEECLKRVRQYLEKAMNDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2N3</accession>
    <name>G0S2N3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Circumsporozoite protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0017850</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692285.1">
        <property type="nucleotide sequence ID" value="XM_006692222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2N3"/>
    <dbReference type="STRING" id="759272.G0S2N3"/>
    <dbReference type="GeneID" id="18255823"/>
    <dbReference type="KEGG" id="cthr:CTHT_0017850"/>
    <dbReference type="eggNOG" id="ENOG502QUVP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038962_0_0_1"/>
    <dbReference type="OMA" id="KCTPTID"/>
    <dbReference type="OrthoDB" id="2141239at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409241" description="Circumsporozoite protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="36469" checksum="D0A033A60AE392D1" modified="2011-10-19" version="1">MYAKAILAAAFIASVEARFGQEGAVQAIVQALGNFGQPGQAATLAGQTPGVLLAGANACAKLQLADQIVATLGNDPQVIEAAKALVAAEKNFNPFVQSIPTICSDVNLPATPELRGIVPLVDPAVVGSDIENANSARSLQNPFNANGLSVADIMEANGFSNFTRQASNGQTAGNNGGNNNNNNNNNNNNNNNNGGGGGAATTTSAVATTTRAACAVRTTLTTVIVTASPTANPATGNNNNNNNNNTGVQKSTIPGLDFGSCVPTMKFVGGLGGRPATEFTFQSKDPKIAARQQEALNPNIITNRICDELTNICGANQAAKDACQAAKAEIQALGTRNAQTAERWNELLGFAGTDVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2Q3</accession>
    <name>G0S2Q3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 11">Glycylpeptide N-tetradecanoyltransferase</fullName>
            <ecNumber evidence="5 11">2.3.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CTHT_0018070</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>N-terminal glycyl-[protein] + tetradecanoyl-CoA = N-tetradecanoylglycyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15521"/>
            <dbReference type="Rhea" id="RHEA-COMP:12666"/>
            <dbReference type="Rhea" id="RHEA-COMP:12667"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133050"/>
            <dbReference type="EC" id="2.3.1.97"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the NMT family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.97" evidence="5 11"/>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692305.1">
        <property type="nucleotide sequence ID" value="XM_006692242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2Q3"/>
    <dbReference type="STRING" id="759272.G0S2Q3"/>
    <dbReference type="GeneID" id="18255845"/>
    <dbReference type="KEGG" id="cthr:CTHT_0018070"/>
    <dbReference type="eggNOG" id="KOG2779">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022882_2_0_1"/>
    <dbReference type="OMA" id="GWKRDWH"/>
    <dbReference type="OrthoDB" id="60315at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004379">
        <property type="term" value="F:glycylpeptide N-tetradecanoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000042">
        <property type="entry name" value="Glycylpeptide N-tetradecanoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000056">
        <property type="entry name" value="Glycylpeptide N-tetradecanoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000903">
        <property type="entry name" value="NMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022677">
        <property type="entry name" value="NMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022678">
        <property type="entry name" value="NMT_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022676">
        <property type="entry name" value="NMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377:SF5">
        <property type="entry name" value="GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377">
        <property type="entry name" value="N-MYRISTOYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01233">
        <property type="entry name" value="NMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02799">
        <property type="entry name" value="NMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00975">
        <property type="entry name" value="NMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00976">
        <property type="entry name" value="NMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase N-terminal" evidence="14">
        <location>
            <begin position="193"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase C-terminal" evidence="15">
        <location>
            <begin position="360"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGS22286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="578" mass="64539" checksum="53453642348B0637" modified="2011-10-19" version="1">MSEESKQIDPAKEVEPPKQPAPESDEESGSDAGETKPAGAGAESAAAGSKKKKKKNKKKSKPAATTAGIANSGDAAAAAVATVAQAAGAIAGAADAKKALEGLTPQQIQEFISLNPALANELLGGDAASGSSQQQAMIEAFKKLKLQDIMTGLASSGKNRKDMASYKFWSTQPVPQFGEEETKIVEEGPLRIQKVEEISTEPIPLALEPFRWVTMDLSDEKQLEEVEKLLYGHYVEDDEAMFRFKYSRGLLRWSLLSPGWRKEWHVGIRSGNTLCAFISAIPTNVRVRNNVIQAPEVNFLCIHKKLRGKRLAPVLIKEITRRINLDNIWQAIYTGGIVLPRPVSTCRYFHRALNWMKLYEVGFSPCPPNSKPEFQARRYKLPTQTSTAGLREVEKKDLEQVQDLLERYLKRFELTPVWTKEEVEHWLLPKRDAPGEQVVWTYVVESPSGKITDFFSFYCLESSVIQSTKYSSIKAAYLFYYATEAGLGQPEDRILLKKRLNELIHDALILAKRHNFDVFNALSLMDNPLFLEQQKFGPGDGQLHYYLFNYRANPIHGGVNKRNQLEDGVSSGVGFVML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2Y3</accession>
    <name>G0S2Y3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0018920</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692385.1">
        <property type="nucleotide sequence ID" value="XM_006692322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2Y3"/>
    <dbReference type="STRING" id="759272.G0S2Y3"/>
    <dbReference type="GeneID" id="18255930"/>
    <dbReference type="KEGG" id="cthr:CTHT_0018920"/>
    <dbReference type="eggNOG" id="ENOG502SJHR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031811_5_1_1"/>
    <dbReference type="OMA" id="AGCHDTG"/>
    <dbReference type="OrthoDB" id="3512845at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057683">
        <property type="entry name" value="DUF7923"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057654">
        <property type="entry name" value="Znf-CCCH_tandem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543:SF1">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25540">
        <property type="entry name" value="DUF7923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25542">
        <property type="entry name" value="zf-CCCH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25543">
        <property type="entry name" value="zf-CCCH_tandem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="394"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="394"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="251"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="23"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="320"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS22366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="507" mass="56200" checksum="A97EB5B1EFCC5EDC" modified="2011-10-19" version="1">MLSDQEIARAALELAEFRRNDALAKLLDQYEVLIQSYKRLKSDYEEEREAREKYKQMAKDQERNPFVLVLVDGDGYVFNENLIAKKAEGGNIAAQMLNDEIKASLRRRGLEHCQIMIRVYANVKGLSHALCKAGLVGGESRSLAPFIASFNRSYGLTEFVDAGELKENADFKLRALLRLYADNTQCKHIYFAACHDVGYISELTPFMGNSSKFTLINTPGIRFHDEFTKLGMGIEEFRNVFTHRPLDGLPYRPATNGTGNHKIPAVPTSPIKPSATLSTPSTKSSSKDESKTICIFHTIGKCRYGKSCKNLHPIEASSDVKSVPSTPTFSTTSSSKIAPTTDEFPGPFANLVADLPRKSDIPPGFVAVNANNYRLDPILPRITPEQQSRLKARIDKRRVCNNYQLSGRCDNGDRCEYDHTPLEEDLKPALECLARSQPCSRRGACRIDGCPHGHICQILDCKFRGGKTYCRLGHLAHGEKLVFDRLVPAIGRKGTGSVMSGSSASSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G0S306</accession>
    <name>G0S306_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cerato-platanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0019200</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692408.1">
        <property type="nucleotide sequence ID" value="XM_006692345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S306"/>
    <dbReference type="STRING" id="759272.G0S306"/>
    <dbReference type="GeneID" id="18255958"/>
    <dbReference type="KEGG" id="cthr:CTHT_0019200"/>
    <dbReference type="eggNOG" id="ENOG502SHQD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083928_0_0_1"/>
    <dbReference type="OMA" id="DQSQGAH"/>
    <dbReference type="OrthoDB" id="5370830at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38850">
        <property type="entry name" value="CERATO-PLATANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38850:SF2">
        <property type="entry name" value="CERATO-PLATANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409253" description="Cerato-platanin" evidence="1">
        <location>
            <begin position="19"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="31614" checksum="61256F597177A7D8" modified="2011-10-19" version="1">MRWFTFVSSLLAATGAYAAKGTIWATPHESYSSSVGVLGCKVDTNRIAYWPNSVDCNNICVKLKYEGRELTLLRIDQSEGAHDISYSAWNYLYTGYWATEKPAVGGPLPMEYEDVDPSQCADIIKTKDHKLPLSASNSMNFLASCLATDTWVGKNYQLYNILDPICSWGHNEKCNLDWPNNNQASCPHQLGTPAVLTDTPVYNVQYMTGKLVLASSGQVVDGTGAQPADSAASTVTPTLPLPSLTSLPTPLTVVVSHLKQNMGGRSSQGNKVAMMTMGFFSYWLLYGLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3A6</accession>
    <name>G0S3A6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0020310</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692508.1">
        <property type="nucleotide sequence ID" value="XM_006692445.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S3A6"/>
    <dbReference type="GeneID" id="18256069"/>
    <dbReference type="KEGG" id="cthr:CTHT_0020310"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_228664_0_0_1"/>
    <dbReference type="OMA" id="HRVRYLD"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45398">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45398:SF1">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="23"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1828"/>
            <end position="1904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1907"/>
            <end position="1936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2523"/>
            <end position="2632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2718"/>
            <end position="2803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2529"/>
            <end position="2558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2592"/>
            <end position="2621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2718"/>
            <end position="2729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="2766"/>
            <end position="2778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS22489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="2803" mass="311365" checksum="D11AB6B69FC11F4A" modified="2011-10-19" version="1">MAAVPRPRTQRHRIDTETSWLFLEDETTEARLLVSVAKVLGISTDDVRVDVSFCDLGGNEQSAIELHKACLDAGLDVAVKDILRCSSLSELQTCITPLVQTDAVRPVIQPTRPVPNIPKEGAQVTSIRSPGGMSDTSVERTEIELALGPQPEIGRIATVRPKAGLLEGKLVALLTLLSVEPTPQDGVSTIHLVPHSHAILSSTLILHLKEVAASRLPQDAIPDAWIVLESMPLTDDGKINMRLLRTWVQNINEDVYHRARSLEQQDVFQPPQTDMEHLIHRLASKVLSIPSSRIGVNFSFCQLGGNEQSAQDFVSLCRLEPLHLTLPEVLSSMTLSELAAMAAARSNLEHEWNEPNLDCFGLSPMQHLYFETNWGGDRLLRAARDGTYRFNQSLLLRVKQPVTYEAISSAIRTLVSHHPMLRARFRCGRQGWAQRILPEVTGSYQLLFHSGIRTSEDLEEIIEQTQLAIDIEMGPVFAANYIMTDDGDQLIYLIAHHLVVDLWSWRVIIHDFDELLQNGRVISEQSTGFQKWIEMRKASAVTPTLESLLNLSTKFPGDYMFKGDYAYWGVQDIRITYGHVRDTTFELSYEHTHILETVCNQVFQTESVDIYLAALMLSFAKTFHDRRVPVVWNEEPDRGAWNPDIDVSGTVGWFTLLCPISLAIEPSADFIDVLRRLKDKRRSIPEHGSRYFASRFYHYDKDEIRKYDQPFEIIFRYTGSQQLEPENGVLEKVSIPGRRSLISPTADTGDMVGRIALFEISCVVDQGKAFIRFLWDTNSPDMRVERWIENYQSVLYEAIDRLRFHPPELTLTDVPDLNVTYEGLAQFHAERLAVLRLPSVREIEAIYPITAVQQSILICQLLRPDSCYLHAIYEFSDPTGEPIDDRRICEAWKQVVARHAALRTVFTESVCERALWDMVILRKTHPDMMWFEAGPTEDPIAMLNGQAPLKVTEYKPLHRLAVCTSPTKTFVKLDISAALCDSISLSLLFHDLQRAYTGELPIKEPELFTYPQYIYFLGTARSEPSRDYWRDNLMGLSPCHFPHLTLQGDQLPFSTICVSLDVGFSELSNFVELHHSTIGSLLRLAWAIILRSYTGSNQTIFGFQASGRDDSVIGMKHAVGSFAHIIPCNYDLEPYDPLTKALEMIDLQYEERQQHQYFSLADLQHAIGMKGGERLFNTCLIVEQPVTLNSKFTKRTRLISLQQSLDFDVVVNVRFASGKLVVDIGQRIMSPEQAVNLAHTLGQAIRAIIKYPNTSIALVDLFTSRDREQISAWREEGSHRASQQTLTMVHTLIENKARAQPQAQAVYSWDGAFTYEQLEEEATKLARWLRHECYVDTHTVVPVVMDKCRLAPVAMLAVLKTGATFVPIDSLELGMIQPIFERLNTNIAISSERPVPVLTNLFEKVVVLTESFMKALPSDLPPFSATVTFSDPACIFFCASSSSEARGITFSHAALSTALLGQGPAAKIGPESRVMQLSSFNVDICITEIFTTLVHGGCVCIPSNAERLQDFGAAVSRLKVNWSYMTPHLSRKIIPAQTPSLKVVCFRTRNLDEDTYLIWHGRVSVILAYGPLEGCPLGIAFLEALVPQHLKCIGRPFAGDFILVNPDDQKKNVPVGAVGELILKGPTLGVAYPNRESTLSPMSPVGTSMGMAAIRYFRPRHLARYIEGGLMEFILKDREDAEGSNKYFNVSITEVEQHVRRCLRQMALDVSVELILFRTPIRTDPELVAFVELGDGIGPEETLGALSLATREQLAIIKQKVYAELKNIFPRNLIPAIFVPVRHLPVTTSLKINHRRLQRMISGMSREDLLNLSSVIRTDARFQYLKPLPLTASEERMRNLWAQVLGLEAASISATDRFFAIGGDEIMAVELVLTCRQEGILVSVADVLSNVTLTELSRRTMVTTTTITSSPDSARLHASPVLSTSPSSASPPAVTNPNAAQVQAHAAQSHSKQDFITYIIAPSLRVEPSAIADVAEASSAQVRYIETGMLSSRVNVNYLVFSFTGAVDSKKLEIACRTLVELHPILRTAFVTYNRRVWMAVLKSADIEFQRHYVSWTTSLNALQEKVIRKDQSIPVDFRTPVTKFMFLDGGKQSVMLLRLSKAQYDDLSIALLVKDLKRLYDGQQPPPQRKHSYCDFVNAVQSANVGGAAEAYWREWLAGASVTQVVHHLRPYKMVTNIKMVKEIIPSLDSCQALGCRVETLLKAAWAMVLATLARSSDVVFGEVIDGRNMKLPGGYPVSRIMGPTVNIIPVRVQFPDTRLTTLELLSYIDAQRQACMPFENMGFLTIVENCTPWVYWTRFSSIVHHQVEERAIIPSEPKTFHLGNAACKFTVHESKAQDLPDLYVRSIARPGGRFEISITFSPDRAQGLEQVAGDALRLLCDTIRYLLPGANKHEPLIPPGYYYRELQHGKIPLSATIPSRGEGEDVIPNWMTPDQVQAIRMAVMETWADILDPISLGVPQEQVLLASFYDLWGSLIPASQMMKQLNLVVPGLTIPGVDASDVSVTMEEIIDNPSIETQTRLIASKCKPKDVNKSKDKVKTTKERGNDDNKDAKSKDLSPPPGPGHKKKPRMTLPILPQSIGSRLKRYASVSRTNTLPNTSRTSSNTKEESNGNSTTQRKPSLYRPPPAPTSPVAIGLASAMVADLSPLMPRVVGSVAPVLNSAPPPRQPGSAPPQIPVFDTIAEESETEEGWINVLTPPHPLLTHQAQGLGSQISLGTSSQDAQTPRSVAPPLPLKERAPSPYLFSAPGSGAGRGSPAERGRAGTPGGGSGSGAGAMSGESVGLGPTGGAEENVGSGSLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3B4</accession>
    <name>G0S3B4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0020410</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692516.1">
        <property type="nucleotide sequence ID" value="XM_006692453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3B4"/>
    <dbReference type="GeneID" id="18256079"/>
    <dbReference type="KEGG" id="cthr:CTHT_0020410"/>
    <dbReference type="HOGENOM" id="CLU_164943_0_0_1"/>
    <dbReference type="OMA" id="GIFWWQT"/>
    <dbReference type="OrthoDB" id="4561045at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="97" mass="9699" checksum="E8AB0F00CEE99588" modified="2011-10-19" version="1">MSQVSRKGPLLIFAAVAGGLLYATYGGRQQPRPLARGSGAPGISEALESAAGTGGTRARGLDEPVGPPGSDIKDAHIGTSSTDAPSKRSAGKEERGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3Q0</accession>
    <name>G0S3Q0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0030180</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693472.1">
        <property type="nucleotide sequence ID" value="XM_006693409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3Q0"/>
    <dbReference type="GeneID" id="18257056"/>
    <dbReference type="KEGG" id="cthr:CTHT_0030180"/>
    <dbReference type="HOGENOM" id="CLU_1128946_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="246" mass="27141" checksum="158DD62DAF133CF6" modified="2011-10-19" version="1">MAPTSQPLFSPQFSTQLGLPGLQLVWAWLASLGPSRILARWTLVGPFLGLSWAVLGAVASAANRQIHRIGGMSMRFMDRGTTGSKKSQDRWLWPRRLAACHGSRREARMRQEEEEGGEHPIVTRRACLSSAGAWGALKCSGCWPTEVLLLEVLVPVWALWLFAGPCCPRRTHCPPFVFLLPLNEPPLAAKQLRCATLKAGNFGTAARQATRQELVRPPSMLAELPFQHSSTSKVCQWPLLAVRSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3T4</accession>
    <name>G0S3T4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit J</fullName>
            <shortName evidence="5">eIF3j</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 30 kDa subunit homolog</fullName>
            <shortName evidence="5">eIF-3 30 kDa subunit homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">HCR1</name>
        <name evidence="7" type="ORF">CTHT_0030560</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit J family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693506.1">
        <property type="nucleotide sequence ID" value="XM_006693443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3T4"/>
    <dbReference type="STRING" id="759272.G0S3T4"/>
    <dbReference type="GeneID" id="18257094"/>
    <dbReference type="KEGG" id="cthr:CTHT_0030560"/>
    <dbReference type="eggNOG" id="KOG4813">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087988_0_0_1"/>
    <dbReference type="OMA" id="KPHYALW"/>
    <dbReference type="OrthoDB" id="20381at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.60:FF:000003">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.60">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03009">
        <property type="entry name" value="eIF3j"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023194">
        <property type="entry name" value="eIF3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013906">
        <property type="entry name" value="eIF3j"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08597">
        <property type="entry name" value="eIF3_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS21210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="279" mass="30793" checksum="C049DC38346D17EB" modified="2011-10-19" version="1">MPGPSKRWDEEEESIAGSAPGSPVIGARRNRKFDDEEEGNDDVLDSWDAAEDSEVEREKARKAAEAKAKAEAEAAAQKKSKTQRIAEHQAQRARAKAAAEAEQEEEETEAQRRERLRRTEKESDLKHAEDLFGNIGTISGRSLTATTVQVDPNDPNNTIDLATLPIFNPQGKAAFEQLRNTLAPLLAASAKKPHYTLFLQEFCKQLARELPSEQIKKVASSLTALSNEKMKEEKAAEKGGKKTKAAKTKTSLVGVSRNDKADLTAYDDAYEDFGDDDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-12-14" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3U8</accession>
    <name>G0S3U8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0038950</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS22010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694306.1">
        <property type="nucleotide sequence ID" value="XM_006694243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3U8"/>
    <dbReference type="GeneID" id="18257933"/>
    <dbReference type="KEGG" id="cthr:CTHT_0038950"/>
    <dbReference type="HOGENOM" id="CLU_2399468_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS22010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="93" mass="10019" checksum="9AB3687CA32A3938" modified="2011-10-19" version="1">MGFPTFLSRVPSRLLSDVLDGAQQLYSNGDEGVELLDLLAGLLKSGKNPRSRGPISARVLGGRDVASRSAQVNHSWLIYSYSASSDWLDPGLD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-06-24" modified="2025-04-09" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0S450</accession>
    <accession>G0ZGV0</accession>
    <name>SEH1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleoporin SEH1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Nuclear pore protein SEH1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">SEH1</name>
        <name type="ORF">CTHT_0030710</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Involved in nuclear poly(A)+ RNA export and NPC biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 6">Component of the nuclear pore complex (NPC). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Nucleoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="1">Symmetric distribution.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JF276294">
        <property type="protein sequence ID" value="AEL00688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693520.1">
        <property type="nucleotide sequence ID" value="XM_006693457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S450"/>
    <dbReference type="STRING" id="759272.G0S450"/>
    <dbReference type="TCDB" id="1.I.1.1.2">
        <property type="family name" value="the nuclear pore complex (npc) family"/>
    </dbReference>
    <dbReference type="GeneID" id="18257109"/>
    <dbReference type="KEGG" id="cthr:CTHT_0030710"/>
    <dbReference type="eggNOG" id="KOG2445">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032441_5_0_1"/>
    <dbReference type="OMA" id="WFRLWAE"/>
    <dbReference type="OrthoDB" id="5566198at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF3">
        <property type="entry name" value="NUCLEOPORIN SEH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0509">mRNA transport</keyword>
    <keyword id="KW-0906">Nuclear pore complex</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0853">WD repeat</keyword>
    <feature type="chain" id="PRO_0000433193" description="Nucleoporin SEH1">
        <location>
            <begin position="1"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 1" evidence="2">
        <location>
            <begin position="27"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 2" evidence="2">
        <location>
            <begin position="72"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 3" evidence="2">
        <location>
            <begin position="191"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 4" evidence="2">
        <location>
            <begin position="260"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 5" evidence="2">
        <location>
            <begin position="332"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 6" evidence="2">
        <location>
            <begin position="484"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="110"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="374"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P53011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="21784248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <evidence type="ECO:0000305" key="6">
        <source>
            <dbReference type="PubMed" id="21784248"/>
        </source>
    </evidence>
    <sequence length="538" mass="58970" checksum="0FB29AF5BCF35F3E" modified="2011-10-19" version="1">MSKAAAFLTDPPLVDDRPSFETILKHGHQDLVQAVAFNGHGDRCATGSVDGKIRVFNRLKEGIWRLCDNWTAHAGEILELQWLPTTVYPNLLASLGIEGRFKLWAEDPSAAPGRRFAESTRNGPLITIPSPRLSSHPSHLTHSQHPQQQPHHHHAPESILPSNPPPTSNPPQATGSTTAGSGAKPAFETRNPRSPYRSFSIKHIDDTRTTYLALLSADGGLTVYENDRVENLAAFSLMDEFNVLDPTAATGPGQASTAPRGQETSFRVRFDPNPDVCYTALRDGVLSDALGLVVAVQDTVKVYRTRDAVRASLGLAAATKEFYLAAEVVAGVHRGLVRDVAWAPGNIRGYDIIATACQDGFVRVFRLDTLSPSTSDTTKFAREPSSIDLTQGGELDDEKRAQESAPESRWSSSRVRRHATRRQGPSQDALTITTSGLRASLDSHNHQQTPSRELDAADRRSRRAWTNQPGQVRHTLTEISRLDNHRTPVWRVAFDDDGQILGSVGDEGKLLCYRQKPDGTWAKSSEMSVVKVKMAAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4P0</accession>
    <name>G0S4P0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0023010</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692765.1">
        <property type="nucleotide sequence ID" value="XM_006692702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4P0"/>
    <dbReference type="GeneID" id="18256339"/>
    <dbReference type="KEGG" id="cthr:CTHT_0023010"/>
    <dbReference type="eggNOG" id="ENOG502QWBR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040566_0_0_1"/>
    <dbReference type="OMA" id="FFYHNNS"/>
    <dbReference type="OrthoDB" id="25131at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00413">
        <property type="entry name" value="Glyco_hydrolase_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121:SF5">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408831" description="GH16 domain-containing protein" evidence="1">
        <location>
            <begin position="47"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="71"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS20469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="442" mass="49344" checksum="BE3A3A86807FEAE0" modified="2011-10-19" version="1">MVASSWLSRLLSSSHSLQSFSVQISTRSLSSLSLWTLFLFSPLALADCECGYLSTVGDGVGNSQVDTSDPSIWRQTPSDSSNLALFTDLLETDFTRVYSSGNRYDVSKDTDWVPQAFNLTKERARGEWGEMFDVRNVFSYPPNKNRQSQPGEDEMKWGPKHWNSDDKATGLKLVVRSDVVDGMVPVAEVATRRLDFLYGSFRASMKISDIPGTCAAFFWYFNDTQEIDMEFLTREFNRENKTFPINLVLQSRESALAGHDASGTGESNFIHTNLPFDPTLDFHEYRIDYLPTRVIFYADGKPLATMAASRGAAVPTSQGHLILSHWSNGNPLWSGGPPKEDSALTVKYVKAYFNSSSETRQDDWRARCQDPKAKGAVCRIPDVVPGDKTAVDWYFKFQGNMTNNQTMSSEPEEDAAVRLGTAGRLAWIASVLAGFVIWVNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4P6</accession>
    <name>G0S4P6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1770 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0023070</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692771.1">
        <property type="nucleotide sequence ID" value="XM_006692708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4P6"/>
    <dbReference type="STRING" id="759272.G0S4P6"/>
    <dbReference type="GeneID" id="18256345"/>
    <dbReference type="KEGG" id="cthr:CTHT_0023070"/>
    <dbReference type="eggNOG" id="ENOG502SAKD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101474_0_0_1"/>
    <dbReference type="OMA" id="GWRHWNR"/>
    <dbReference type="OrthoDB" id="2430343at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140580">
        <property type="term" value="F:mitochondrion autophagosome adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013898">
        <property type="entry name" value="Atg43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38699">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38699:SF1">
        <property type="entry name" value="MITOPHAGY RECEPTOR ATG43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08589">
        <property type="entry name" value="ATG43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="19887" checksum="079BD424C1062862" modified="2011-10-19" version="1">MADSVPLQIADTIQTAHIQRHPSPLHDVNPPHGAGSTAEPVYVDNEGIDEGEEELDTSEEEEYRSSRSAVPRPRKPQHHFPPLPDLRFEQSYLWSIRNADTWWKVVAITVRDQVMMPLLQGIVYNLFICGWQYWNKSAQIHGSSVGARLRRWWYGVNKWPIPPPAQSGRRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4R7</accession>
    <name>G0S4R7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pumilio homology domain family member 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0023280</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PUF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692792.1">
        <property type="nucleotide sequence ID" value="XM_006692729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4R7"/>
    <dbReference type="STRING" id="759272.G0S4R7"/>
    <dbReference type="GeneID" id="18256366"/>
    <dbReference type="KEGG" id="cthr:CTHT_0023280"/>
    <dbReference type="eggNOG" id="KOG1488">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004017_4_0_1"/>
    <dbReference type="OMA" id="KEWIFRE"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000004">
        <property type="entry name" value="Pumilio homolog 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUM-HD" evidence="10">
        <location>
            <begin position="487"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="8">
        <location>
            <begin position="509"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="8">
        <location>
            <begin position="545"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="8">
        <location>
            <begin position="581"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="8">
        <location>
            <begin position="617"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="8">
        <location>
            <begin position="653"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="8">
        <location>
            <begin position="689"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="8">
        <location>
            <begin position="767"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="87"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="331"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="833"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="138"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="838"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="848"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00060736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00081811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS20496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="866" mass="93697" checksum="8288CE89E584DC28" modified="2011-10-19" version="1">MTNSPRPTIATTSRFFGASSSSTGNGNGRSQQQELVNGNGFTGWPTGTSSIWGTNGVSNSLPNGAGAASVRRGSSTIETLSRAADGLSRSNDVDGSSVTNGGHALASWTSPWSQTASLPRPQSGNTSPRSHASVYETYGSTAQLDSTPSNAQRTQARSRPQTSSMEPSYNNTSFADYPHENGTSDSYPQLRADSERFTAFPRNQRPFGQSLLNGAVGTNHSEGTRTSLPHPFGGFAYPPSASHSQRPSLAAISTGYNVSNTNGHAEETSSISDIENTLRNVTIGSGLNGIASNGGSNGVSNGVSNGLSNGLSNGAPTSGFGSFGSSTNGSQAFQFNPISQPWESSQENPLGFGAARPTLPTPAPTPADDVAYFAALASALNGSRTSQQQQTMNLWAPSSSQQDPRVRPDMDRRGFNQPFLQAPQTLMPPSSFYGANFPPYPPAPFDTYSPVRPNFPSMSAVPLLNLYGIGPGAVPFGSRDHDPSRDVRSVLLEEFKSSSKSSKRWELKDIRGHIVEFSGDQDGSRFIQQKLLTANSEEKEWIFREIEPNAVQLMKDLFGNYVIQKFFEHGSMAHKTKLAQAMHGKMFDLSTQTYGCRVVQKALEHVLVEEQAVLVKELQPEILKVIKNQNGNHVVQQIIAVVSRSEIDFIMDSMKGRISELASDAYACRVVQRVLERGTDDDKAFILKELHACAQMLVVDQYGNYVAQHVIQHGKPEDRSKMIEVVIPQVVGLSKHKFASNVVETCIAHGTPEQQRAIRDQILPANDTQNSLLQLMKDPYGNYVIQKLLDTLKGQDRDVLCVKMRPLFDILRKQGHSGRQAAAVDRLWAAINRPQPQPQVQAQAATQNGNSTQSNHPAPSSSEIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5I1</accession>
    <name>G0S5I1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CobW/HypB/UreG nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0033040</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693742.1">
        <property type="nucleotide sequence ID" value="XM_006693679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5I1"/>
    <dbReference type="STRING" id="759272.G0S5I1"/>
    <dbReference type="GeneID" id="18257342"/>
    <dbReference type="KEGG" id="cthr:CTHT_0033040"/>
    <dbReference type="eggNOG" id="KOG2743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017452_0_1_1"/>
    <dbReference type="OMA" id="GHSHMDP"/>
    <dbReference type="OrthoDB" id="258627at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03112">
        <property type="entry name" value="CobW-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051316">
        <property type="entry name" value="Zinc-reg_GTPase_activator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748">
        <property type="entry name" value="COBW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748:SF31">
        <property type="entry name" value="ZINC-REGULATED GTPASE METALLOPROTEIN ACTIVATOR 1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="2">
        <location>
            <begin position="29"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS21446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="371" mass="40426" checksum="25EBAF440AEA70F9" modified="2011-10-19" version="1">MEWDDDDGPPELVGTGLGEEPEERPVKVPLTIVTGYLGAGKTTLLNYILTAEHGKKIAVIMNEFGDSLDIEKSLTINKDGESIEEWLEVGNGCICCSVKDNGVAAIESLMEKKGKFDYILLETTGLADPGNLAPLFWMDDGLGSTIYLDGIITLVDAKNILRSLDDPAGKVQGHEEAEDDNGPVMTTAHVQISHADVIVINKADLVSEGELQAVRDRIESINGLAKVFVTTQSVVPQLEGFLLDIHAYDRAEGLDHAATGHAHLDKTISTISIPLPELTESQESAMDAWLRSVLWDNVLPGHKPHKGPAYDIHRLKGRFFVKYGSEKIVQGPASLEQTTDIFNSVIVDKRANKIPIRFRTSHGFPDIPSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5L4</accession>
    <name>G0S5L4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0024670</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692929.1">
        <property type="nucleotide sequence ID" value="XM_006692866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5L4"/>
    <dbReference type="STRING" id="759272.G0S5L4"/>
    <dbReference type="GeneID" id="18256505"/>
    <dbReference type="KEGG" id="cthr:CTHT_0024670"/>
    <dbReference type="eggNOG" id="KOG4178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_7_5_1"/>
    <dbReference type="OMA" id="YQIPMLV"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="112"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS20633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="428" mass="48191" checksum="19FD3721B0E3537E" modified="2011-10-19" version="1">MQLVRAPKACVKLWDIPSSQDLRRARVCTAEWPTFGRARDARLHSTPPSTSLLELKSTFRLELSIEMAAVDKLTPSDSRVQHRTYTVPASNHTYHYLFAEPPARTTVTGTALLIHGFPDLALGWRYPLVSLGLRVIVPDMLGYGGTDAPEKLEEYSYKSVTNDLVALVRHVLREAGHKDPESEKIILGGHDWGGMVAWRFALWHPSVLRCVFSVCTPYFAPISQPITLEVLTSIHSNFRYQLQFRSGECEARVGRDPARVRAFLGALYGGRALMEDLKTIDEGRKGLFDPEVGIPLDLVEQCRVGPSPLLSKEEMDYYVEQFATGKGGIKGACNWYRMTEINNKEEMELAQAGRVNIRTPALMVVARKDVALKPELAGKMKDFIENLKMVEVDASHWALWERPAEVNAHLTEWLRGILDREGRLRPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5M0</accession>
    <name>G0S5M0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">L-type lectin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0024750</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692935.1">
        <property type="nucleotide sequence ID" value="XM_006692872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5M0"/>
    <dbReference type="STRING" id="759272.G0S5M0"/>
    <dbReference type="GeneID" id="18256513"/>
    <dbReference type="KEGG" id="cthr:CTHT_0024750"/>
    <dbReference type="eggNOG" id="ENOG502QR1C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053733_0_0_1"/>
    <dbReference type="OMA" id="WSAEFQF"/>
    <dbReference type="OrthoDB" id="10265193at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06903">
        <property type="entry name" value="lectin_EMP46_EMP47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035661">
        <property type="entry name" value="EMP46/EMP47_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051136">
        <property type="entry name" value="Intracellular_Lectin-GPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223:SF28">
        <property type="entry name" value="LECTIN, MANNOSE BINDING 1 LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223">
        <property type="entry name" value="VESICULAR MANNOSE-BINDING LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51328">
        <property type="entry name" value="L_LECTIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409319" description="L-type lectin-like domain-containing protein" evidence="9">
        <location>
            <begin position="20"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="L-type lectin-like" evidence="10">
        <location>
            <begin position="25"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="267"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS20639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="453" mass="50695" checksum="3E37AE16058B483B" modified="2011-10-19" version="1">MRFSWGLSTLAAGLATVQAQYLINELSFGFNNRISPEGSRSVPNFSLQGRPTLPELLSDRIILTPVHPGNQRGAIWADKTLQQSTWIADVEFRANGPERGGGNFNIWLVKDGSHAVGTNSVYSVGRFEGLVLVIDQHGGSGGMLRGFLNDGSIDYSSTRDVDNLAFGHCRFAYRNLGRPTQIKLRQTETKFSVEVAGRMCFESDKIRLPSGYNFGVTASSADNPDSFEVFKLVVLTGENSHEYAGMYQTQQQAQQQQQQQQTQQQQQQQQTQQQQPPVQRRQIIPDDPYDNIIPDEDPDKIVSSKAQFADLHNRIQSVNHHLSTIFRSMAQNAAILEQRHSETSQLISDIKGLLSSNNHVVSERLRSLENKIQELDRQITQLQSEFHARIGASENAIMMHVSDRHAALAGDVREHTSSGYMRLLIILLGGQAAMAGGYFYYKKKKMAVPKKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5P0</accession>
    <name>G0S5P0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutamate--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CTHT_0024950</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Glu) + L-glutamate + ATP = L-glutamyl-tRNA(Glu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692955.1">
        <property type="nucleotide sequence ID" value="XM_006692892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5P0"/>
    <dbReference type="STRING" id="759272.G0S5P0"/>
    <dbReference type="GeneID" id="18256533"/>
    <dbReference type="KEGG" id="cthr:CTHT_0024950"/>
    <dbReference type="eggNOG" id="KOG1147">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001882_1_2_1"/>
    <dbReference type="OMA" id="CPVVDSH"/>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1160.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.800.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000037">
        <property type="entry name" value="Glutamine--tRNA ligase cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000004">
        <property type="entry name" value="Glutamyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1160.10">
        <property type="entry name" value="Glutamyl-trna Synthetase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.800.10">
        <property type="entry name" value="Glutamyl-tRNA Synthetase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02076">
        <property type="entry name" value="Glu_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004526">
        <property type="entry name" value="Glu-tRNA-synth_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020061">
        <property type="entry name" value="Glu_tRNA_lig_a-bdl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00463">
        <property type="entry name" value="gltX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF5">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13 17" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="14">
        <location>
            <begin position="121"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="15">
        <location>
            <begin position="429"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="16">
        <location>
            <begin position="533"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGS20659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="637" mass="73316" checksum="86C3D457B1574CD6" modified="2011-10-19" version="1">MKIDDIKALEKVLAGDFRSIEPHLQALDKHLILRTYLDGYTLSEVDTKIWQVLRSNRAAFSFIKRGNLVNLTRWFNFIEDNYPEIQEEIKARDAAAKAKVAAASKAGGSYNLALQDTDKGVVTRFLPEPSGYLHIGHAKAALLSDYFAHIAYNGQLRLRLDDTNPSKEKQEYQDAIIEDLAMMGIRPDSVTYTSDYFDYLYEMCIRLIKEGHAYADDTDQETMRDERFKGIASKRRDRSVEENLRIFEEMKKGSEEGLRHCIRAKISVDNPNKAMRDPVIYRCNVETPHHRTGTKWKMYPTYDFACPIVDSYEGVTHAMRSTEYTDRNPQYQWFQDTLKLRKVYIWDFARMNFIKTFLSKRKLAKLVDTGRVWGWDDPRMPTIRGIRRRGMTINSLRDFILKQGPSRNIVTMDWTTFWANNKKEIDPIAPRYTAVLQKDVVKVTVTGAEAPAEPYKSEKPLHPKNKNVGTKQVVYASEILIDQADAKSFKDGEEITLMSWGNAFVRNIPSADPIPTLTCELNLQGDVKTTEKKITWLASNQKLVPAELWDFDYLITKDVLQEDDNMEDFLNPNTATMDDAWCDEAAAVLKKDDIIQLERRGYYRVDKGLDDWKDGEEGPKGKRLVLFCIPTGKTGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5P2</accession>
    <name>G0S5P2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phenylalanyl-tRNA synthetase beta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CTHT_0024970</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692957.1">
        <property type="nucleotide sequence ID" value="XM_006692894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5P2"/>
    <dbReference type="STRING" id="759272.G0S5P2"/>
    <dbReference type="GeneID" id="18256535"/>
    <dbReference type="KEGG" id="cthr:CTHT_0024970"/>
    <dbReference type="eggNOG" id="KOG2472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020279_2_0_1"/>
    <dbReference type="OMA" id="FPGRCAN"/>
    <dbReference type="OrthoDB" id="1698572at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.40.10:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.10:FF:000004">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000052">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="entry name" value="Phenylalanyl-trna Synthetase, Chain B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004531">
        <property type="entry name" value="Phe-tRNA-synth_IIc_bsu_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040659">
        <property type="entry name" value="PhetRS_B1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00471">
        <property type="entry name" value="pheT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947:SF0">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18262">
        <property type="entry name" value="PhetRS_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 17" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B5" evidence="16">
        <location>
            <begin position="294"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGS20661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="604" mass="68709" checksum="DABC81ECFDD32059" modified="2011-10-19" version="1">MPTINVDKYALFEELGEQFTEESFQQLCFDFGIELDKDTENDPARPKDEPPELAIEIPANRYDMLCFEGIAMHLNIFRGKIETPKWRLLDIPEDQMQTLTISKETELVRPYAAAAILRNVTFTQASYDSFISLQDKLHQNLARQRTLVAIGTHDLDTIRGPFTYEALPPKDINFVPLNQTKEINGTELMSFYENDRHLGRYLHIIRDKPVYPVILDADRNVCSLPPIINSERSKITLNTKNVFIDMTATDQTKLDIVCNIMVTMFSKYCAEPFTIEPVKIISEHNGTSRITPSLTYRKMDVEVDYLNGLTGLKESPESICKLLSKMAYKAEPSADPKYVTVTVPPTRADVLHPCDVMEDLAIAYGFNSLPRSTPNKSVTIGKPLMINKLSDIVRHESAMAGWAEVMPLILCSHEENFEWLNRVDDGKTAVKLANPKSIEYQVVRTSLLPGLLKTLSENKAMRLPLQIFEVADVVFKDDSFERKARNERHWAAAYYGKTSGFEVVHGLLDRVMTMLRVAFITHEEGLTGKSIDFEVHANPQRDGYFIKETDEPTFFKGRAAAIYVRLNGQLQRIGELGVLHPTVLEKFDLRYPVSTLEINLEVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5Z4</accession>
    <name>G0S5Z4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0025460</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693006.1">
        <property type="nucleotide sequence ID" value="XM_006692943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5Z4"/>
    <dbReference type="GeneID" id="18256584"/>
    <dbReference type="KEGG" id="cthr:CTHT_0025460"/>
    <dbReference type="eggNOG" id="ENOG502SDVM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053554_0_0_1"/>
    <dbReference type="OMA" id="GPATKEM"/>
    <dbReference type="OrthoDB" id="5222339at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="334" mass="36619" checksum="AEA801085A7A708B" modified="2011-10-19" version="1">MPQKPIDYSDIKEFIRQQETHPKPLTPQQLRAILDLKRAIRSGELDLGGKDWVSLLLRYRDAHQKSGCSVSFIDLSAPDNTWACRCQIQLSQDSKTLAFPVAYGPEVQGFSRKKDAKQLMAEGYLPSDGENVVFPKTKPNLAIKQPVPPPQCPTAKEATQPEIQAPEQSQSPPSTESDNGAPLASTSSSASNSNSNTAVSSPQVTTTPARKTSPGQDDKDIPATQRVVKLCSLLDIQTPRYHLTPSQPPTDSTDDDLPSGWYFDGWVDFGQDSGVKIPREVIEAASVKQVYGKKQAKERMAEKLLMWLMEEQRSRDQELGALLSGTLAGKEGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>G0S676</accession>
    <name>G0S676_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone-lysine N-methyltransferase, H3 lysine-36 specific</fullName>
            <ecNumber evidence="4">2.1.1.359</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">SET domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CTHT_0025760</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="23 24" key="2">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="3795" last="3795">
            <title>Nucleosome and ubiquitin position Set2 to methylate H3K36.</title>
            <authorList>
                <person name="Bilokapic S."/>
                <person name="Halic M."/>
            </authorList>
            <dbReference type="PubMed" id="31439846"/>
            <dbReference type="DOI" id="10.1038/s41467-019-11726-4"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.80 ANGSTROMS)</scope>
        <scope>DISULFIDE BONDS</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Histone methyltransferase that trimethylates histone H3 'Lys-36' forming H3K36me3. Involved in transcription elongation as well as in transcription repression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60324"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:15536"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.359"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.359" evidence="4"/>
    <dbReference type="EMBL" id="GL988041">
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    <sequence length="939" mass="105268" checksum="0C3CF152179FC12C" modified="2011-10-19" version="1">MEASDRASGPTAGSKSEERTKQNGPRSKKEDASDSSTSTGSKSASRSSSATTMSPDDAKPADDSALAQENGVAPKPSRKSSKLPPRNPPQLFNHLPDATEEACRTFQVISDCLYGSRNMGSSDHDALDCDCAEDWRDGKNHACGEDSDCINRATKIECVIGDCNCGEGCQNQRFQRKQYAKVSVIKTEKKGYGLRADTDLQPNDFIYEYVGEVINEPTFRSRMLKYDKEGIKHFYFMSLTKNEFVDATKKGNLGRFCNHSCNPNCYVDKWVVGDKLRMGIFAARYIKAGEELVFNYNVDRYGADPQPCYCGEPNCVGFIGGKTQTERATKLPLATIEALGIEDGDSWDTTVAKKPRKKKASETDEEYVNSLQPKALDEDGVNKVMATLMQCKEKWIAVKLLSRLQATQDDHLRHRVVRMHGYQILKSTLNAFKHDNNVVLQVLDILYNLPRITKNKISDSNIEAVVQPLASSSDERVAFEAKRLLEEWDKLETAYRIPRKKDGRVVSAIANSFEEERRSNREEPTKPADPLANVVIPTGPRSNIPQRNANYYNGVRPRKPPTNLPEGWFVTVDKKTGKYYFYDVNGKVQWQRPTAPAITTPKPSVKAQQDQKALQDIIDSLTKEPTPRQSAGHTPQRSSTPATEPKKEKWRSLPIEKQMKIYENTLFPHVKYVMDKFHGKLPREDLKKFARDVNKKLVASDYKHNRVQDPTVPLSSKQAKKVRKYVYDFFDRALQKYLEYQKRKAQYTSKEGMQSSQTEQNTATPTGTLGKDVDEVMSDVEAPNSSPQSTSSAGRKRKRDDDQDGDHDMRSPADEDAATSSDPPSVKRIKEDDGTGNDVIPSPPPPPPPPAEIPMTEEERSMREQEEALMRENEEAQRLEDEAKRKQLELQNGLAAAKNAGIELGSASFTVSGEPMDVDNDGPPPQEQAQQQKQAVMSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6I5</accession>
    <name>G0S6I5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0026340</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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            <begin position="60"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="227"/>
        </location>
    </feature>
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        <location>
            <begin position="383"/>
            <end position="665"/>
        </location>
    </feature>
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        <location>
            <begin position="815"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="202"/>
            <end position="213"/>
        </location>
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            <begin position="404"/>
            <end position="417"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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    </feature>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6N3</accession>
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            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR019331">
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495:SF0">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10187">
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    </dbReference>
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            <begin position="33"/>
            <end position="132"/>
        </location>
    </feature>
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    </feature>
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    </feature>
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            <end position="44"/>
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            <end position="175"/>
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    </feature>
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        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS21635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="261" mass="28962" checksum="738A9F4343BA1850" modified="2011-10-19" version="1">MSSRFISAGSIDASKGRSPPNFHTQPPSTFHSEARQKEREEAAHQLEQSRQQSSRSGIGASAEAEPQRSLYEVLQANKAAKQAALEEARRLRNQFRALDNDEVEFLEGIRAREREESERVRNEVERGLEKFREERRKSSGIVGAAGAGNEVLAEEFVFQRKRKAAREGGKKKRARVLLVKKVDKDNEEKEGKESKDQDKNTAKGNKPTAEDTPGPGEKVKPVSRGLATEKTEVVEQTSKATAPFGTKLAGLLVDYGSDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6S2</accession>
    <name>G0S6S2_CHATD</name>
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        <lineage>
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            <taxon>Chaetomiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
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            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
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        </citation>
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        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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    <dbReference type="OrthoDB" id="3561078at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
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            <begin position="18"/>
            <end position="205"/>
        </location>
    </feature>
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        <location>
            <begin position="144"/>
            <end position="183"/>
        </location>
    </feature>
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            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS21674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="21500" checksum="44F950DB6EDDA412" modified="2011-10-19" version="1">MHSRFLILAGLISTAAAVTRVAPAQIVARHELQARQTDISDWIDEIPGLDDLDGAAECVKAMVSIATSMPTPPPELYSWAATQTEENPCKITYPPKVEEAFEDYASSMTSWWSAHSKEYSAALSKCPDVSSLYDEGQNYICTENGSRTTLAGPQATSGSGSGPSSNGSGNNDDDEDVSTGAGHRETATVGLAVALAGFLAVVAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7D0</accession>
    <name>G0S7D0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0036410</name>
    </gene>
    <organism evidence="3">
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        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
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                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006694007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7D0"/>
    <dbReference type="STRING" id="759272.G0S7D0"/>
    <dbReference type="GeneID" id="18257679"/>
    <dbReference type="KEGG" id="cthr:CTHT_0036410"/>
    <dbReference type="eggNOG" id="ENOG502TC9C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_319850_0_0_1"/>
    <dbReference type="OMA" id="KWDEESA"/>
    <dbReference type="OrthoDB" id="610608at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="591"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="944" mass="102353" checksum="25F933FAC6E5B54A" modified="2011-10-19" version="1">MEPAARGRSPGLARVTQKKLGGNTVVNIPYRPRKDAAYLRKTAAVGLEPAQKLKTARTAATPTPTPSCISSSPTPSSTRDYTSSPHPSASVDALSLSGTTPPSSPTMASFSRGLKTATPDSLKPSRPHLILTDTLGKSTPKDSDDEGKPRDQSFRRHHRNIGSIDSILSSTTYVNTHSECSRSESRFSQDIATETEDSDNETPPASQYHPSDHVGNVTHTPRASHSSGSSMSWNSEGQGQSVTEEEERLIDEISSWVLRNTFGKDIDDCASPYLVWDCTYRYIQELEAAANEGHLGFVQATSGQESPSSYGGGGTPGSSNNDNHYGEFCGKGKRKADGGSDDGNGPADRDNQRDEDRDKSSTPPPWSSKMNITNYSCPYRKRNPLRFNVRDYYVCATHSFADMSQLKKHIRAHHPPVQRNAGPFGCPRCLQGFASKADFDAHLRRPDPCVLSSDRNLSDPEDGITQKIISSLEARSMKNKIDNWRSLWKLLFPCDADDSIPDPYFVPVMEIFDLIDESKKFLHQLRDLLELQYRHVLSGANQALGIDLKIRQGLEKSVNTIYRWIETVVDTWEKNKVGTASPFTKTLIERATSSESSIGSTPKLLPPSPAPTPTVAAQAGSSNPAANTTTASGESPSTSGSAGFEGASLPARRRPNPPPKRIKRAELLPKLPPTQIPIPIQRARTPQAQRTTATPIRPARPVLPSQAMPAQTTTAASLNPVPAFQQTWEPPAVTMANTYPIATVSYSAPSETLQHPSLAPTHYSPMDVQQHQHQLEVQPFMSSEQQGDVMHADSMQRDLDGFRSSTSTLHASQLISTTPRSSLTSLQWMRDNRDSSQTLVEAHPPGRCRNLFCPSCNKTLPDDLTMQSPTGLHPVTTGAPNHHSFHTSGGLGPPFTTAPGTGDIPSFAEPVTAWGFDATAGTLHGGGGNGNLFGGGHHGPQEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7E2</accession>
    <name>G0S7E2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">R3H-associated N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0036540</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694082.1">
        <property type="nucleotide sequence ID" value="XM_006694019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7E2"/>
    <dbReference type="GeneID" id="18257692"/>
    <dbReference type="KEGG" id="cthr:CTHT_0036540"/>
    <dbReference type="eggNOG" id="ENOG502S2TY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064119_0_0_1"/>
    <dbReference type="OMA" id="YPRHDPM"/>
    <dbReference type="OrthoDB" id="10256743at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025952">
        <property type="entry name" value="R3H-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13902">
        <property type="entry name" value="R3H-assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H-associated N-terminal" evidence="2">
        <location>
            <begin position="121"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS21786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="395" mass="43917" checksum="CED03EB92E4A104D" modified="2011-10-19" version="1">MAITRIPETSDEEHHEEHTQYAHLQPSQSLDHHNSHHHSLSNASTATVDIEAWTIAALESLNIAPVARGIGNALSIPLDEQAPHRSAADHDPGATPQMKLRGVKFGDDDDAYGASITPPRRPPSRRDSLRKREALLKGKEGSRQRRRWENDHLIGVPNAQPPLPCDWEIRPTYPILPPVPYQLAQYWDNKARSAPTTRSKSSRGDKSETQSTVGHVPRDLRATAKRTPAVKSWLRVLEEPVRQFVVERGLLAASVKEKIVSNDNKRPSDESEGGDEDEIVFKGRRELRRGSAGASVHEGSSKLTQQQGALSSEQGVGHQLVENGMVLETEDDASGAFKRWLTHSISDYYGLDSKSITVGNPARRIVYIGIKQKQSPRRKPPASRPVLPPPLWEMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7G0</accession>
    <name>G0S7G0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Wings apart-like protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0028010</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WAPL family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693258.1">
        <property type="nucleotide sequence ID" value="XM_006693195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7G0"/>
    <dbReference type="STRING" id="759272.G0S7G0"/>
    <dbReference type="GeneID" id="18256839"/>
    <dbReference type="KEGG" id="cthr:CTHT_0028010"/>
    <dbReference type="eggNOG" id="ENOG502RZXD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011973_0_0_1"/>
    <dbReference type="OMA" id="NNKPKAC"/>
    <dbReference type="OrthoDB" id="78088at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039874">
        <property type="entry name" value="WAPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022771">
        <property type="entry name" value="WAPL_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22100">
        <property type="entry name" value="WINGS APART-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22100:SF13">
        <property type="entry name" value="WINGS APART-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07814">
        <property type="entry name" value="WAPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Wings apart-like protein C-terminal" evidence="3">
        <location>
            <begin position="388"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS20962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="865" mass="93816" checksum="B99E4C364724AF61" modified="2011-10-19" version="1">MADSADALFGFTPKKRITTYGKAARRRVQPRVVGTLRHTESAPVIPTFSKSSSGSPEFPSVTMRLADTTKSGQNNTKKYGAGARVKPAVEEAQSQPSSGPSKMKQEKDEAKRAKKRRLTREESDQGKPTGPYSTPDSSPTGDRSPVGDNTKCERSKKTASVSGQTTPERDVDMRDNAPISMPFSAKTARTLKNLSISSNSPDVRRQMIPLRLSVSSRSKPAPKTTPPSQPSASSAQALSPAQPVRKRRLIDALAAQAEEESSSSDSDDHVPSAQPSGSRNAAATIPPRFAFSESNLSHASLASPSGTIPRPIMAATKKAGPKFTYSQQRTMLADDDDWLLGGSGSGASLGNASSSSAFFKFGQLTKSSTASKFSYLDEEDDTQNSGAVRSLHELRQAGANSRFADEMDDILDRVGTPSAKSSLLRRGALLEVAQKIKNKDFRQQFRNHSDSGNLFKSLGDETDVVSGYAILAIVTTLLAATTSAHLVCELRSQGLATLVSRLLGQTTDITQIAKDRKQNVSKNGQMTLTTIKYSLLELPVWEKFAPSRLSPRTLALKCLDVLMQQPSAQTFAAEDELLNGEVTEHLFSIVSDSINDSDCWDFPDQPEAIDLYLSLYVLEGHSINAMQSPLSSVTWTREYAPIVASTLEKALEKPVQELADLENLALRISLNITNHNEEASRLFAERGLLRRLAESACSAFGIVVNTLRDKNEEKELAAVTKVLESLIMMLGAMINFCVYYPPASGFLQGDGGRSEPLDGLMKIFAENHAKTADADSMEETQLNVALGYLSILLGYLCLRSPIRSRFVEIHPQKGLQPLLDSIKEFIAFHQKIAEAQDTGLGSGHGAESAALTRLKNLVEQLADLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7H5</accession>
    <name>G0S7H5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="15">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CTHT_0028160</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Protein phosphatase that specifically binds to and dephosphorylates the molecular chaperone Hsp90. Dephosphorylation positively regulates the Hsp90 chaperone machinery.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:20630"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:47005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="15"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693273.1">
        <property type="nucleotide sequence ID" value="XM_006693210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7H5"/>
    <dbReference type="STRING" id="759272.G0S7H5"/>
    <dbReference type="GeneID" id="18256854"/>
    <dbReference type="KEGG" id="cthr:CTHT_0028160"/>
    <dbReference type="eggNOG" id="KOG0376">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_5_2_1"/>
    <dbReference type="OMA" id="IHKKYAF"/>
    <dbReference type="OrthoDB" id="445564at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07417">
        <property type="entry name" value="MPP_PP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000389">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000039">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041753">
        <property type="entry name" value="PP5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013235">
        <property type="entry name" value="PPP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058209">
        <property type="entry name" value="TPR_BSK1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08321">
        <property type="entry name" value="PPP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25575">
        <property type="entry name" value="TPR_BSK1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 14" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="14">
        <location>
            <begin position="158"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="14">
        <location>
            <begin position="192"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="14">
        <location>
            <begin position="226"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="18">
        <location>
            <begin position="428"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGS20977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="628" mass="71964" checksum="0DD838450C45CC72" modified="2011-10-19" version="1">MGTTLSTIKALFAPALISLIIFLILTYVIVPCWTRYRNRYAQYLPLDTLQNQTLSLRGRLHGAFSRLMAWSIWRARRNADRVVVADRGSFDSEAGEELGAVDEETARRMRNQHGGRSGVDTLRRDSWILATETGRRRKKKKEEEGEGVHEMATPEEQAIQFKNQGNKAFAVHDWQTAIDFYTKAIELNDKEPTFWANRAQAHLKTEAYGYAIRDATKAIELKPDFVKAYYRRATAYAAILRPKDAVKDFRQCVKLDPNNRDAKQKLAECEKIVRQLAFFAAIEIGDEPSAAEGLDVDSIHVDDSYDGVRLEGQMTQEFIDDMMERFKKGKTIHKKYVYQIILAVKKIVYDEPTLVEVDVPEGVELTVCGDTHGQYFDLMELFRLNGKPSDKHWYLFNGDFVDRGSWSTEIALVLYANKWLRPNCFFINRGNHETDDMNKIYGFEGECKAKYNERVFKLFSESFSALPLAHLIGKKYLVLHGGLFSDDNVTLDDIRKLDRHKQRQPGQSGLMMEMLWTDPQPEPGRGPSKRGVGMQFGPDVTKRFCERNGLEAIIRSHEVRMEGYEEEHDGKCITVFSAPKYCDMTENKGAYINIGSDYKLRFAQFEAVPHPDIKPMAYAHNALFSALM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7N5</accession>
    <name>G0S7N5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0036960</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694122.1">
        <property type="nucleotide sequence ID" value="XM_006694059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7N5"/>
    <dbReference type="GeneID" id="18257734"/>
    <dbReference type="KEGG" id="cthr:CTHT_0036960"/>
    <dbReference type="eggNOG" id="ENOG502SDG8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071085_1_0_1"/>
    <dbReference type="OMA" id="IAHEAQH"/>
    <dbReference type="OrthoDB" id="5391496at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="333" mass="37085" checksum="586C5FC58FFB069B" modified="2011-10-19" version="1">MDPFSTSYPVFLSPALPSELLSFVLNHCTYPSTLIICSDKAHFISSLVEDFKQQQNHTSQQPQQPAFAPPPHHTTAAAPSNPPQRPQYHPTKTLHKYSSAIAHEAQHHRDAYGGSRPALAHKPKYNKPHPLLTNTLHTLAVSRHICTVFIPTVTHLRAFLSVFSLAQPVTSSNRSKLPQPLPPPRRNRDSGTTGTGTLPILVVYDLLGLHRATSEWSAQGLSSTVATLVEAGKREGMRLVVVERKGHGSRGFDPSRPGDDVEMSQDTELPSRLDEIDEMELKALLEERLPVVNSATLRGAIAQNWAAGRTVELGRVLGRWFRFRRWEWKGHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7P6</accession>
    <name>G0S7P6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0037080</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694133.1">
        <property type="nucleotide sequence ID" value="XM_006694070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7P6"/>
    <dbReference type="STRING" id="759272.G0S7P6"/>
    <dbReference type="GeneID" id="18257746"/>
    <dbReference type="KEGG" id="cthr:CTHT_0037080"/>
    <dbReference type="eggNOG" id="ENOG502QRU0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058495_1_0_1"/>
    <dbReference type="OMA" id="VPFHEFD"/>
    <dbReference type="OrthoDB" id="10014216at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050849">
        <property type="entry name" value="HAD-like_hydrolase_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006384">
        <property type="entry name" value="HAD_hydro_PyrdxlP_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01489">
        <property type="entry name" value="DKMTPPase-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181:SF2">
        <property type="entry name" value="PHOSPHORIC MONOESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181">
        <property type="entry name" value="UPF0655 PROTEIN YCR015C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12710">
        <property type="entry name" value="HAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="232" mass="25789" checksum="99B9CCFDFC52159D" modified="2011-10-19" version="1">MGSVSPATLPALKTNPKFIFFTDFDGTITQQDSNDYMTDNLGFGPELRRKGNQDVLHGRRHFRDAFREMLDSISTPLDQCIDILRKNIDLDPGFKEFFHWAKENNMPIVVLSGGMEPIIRALLAHMLGEEEAKSLQIVSNQVAPRPGKSINDENGWQIVYHDDSGFGHDKSLEIRPYARLPAEERPVLFYAGDGVSDLSAAKETDLLFAKAGRVKDIAAGKLSVKEAASGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8B9</accession>
    <name>G0S8B9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0021190</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
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    </dbReference>
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        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="14"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="61"/>
        </location>
    </feature>
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            <begin position="119"/>
            <end position="148"/>
        </location>
    </feature>
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            <begin position="198"/>
            <end position="318"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="48"/>
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        </location>
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            <end position="311"/>
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    </feature>
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        </source>
    </evidence>
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        </source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="596" mass="68155" checksum="1B7EC86B6BAE0F02" modified="2011-10-19" version="1">MVKSTYQPSSSALPPLPPGWTEHIAPTGHKYYYNAETKESTYKRPGVTPTPPPPPPAAVPAAPVAVPGALPTAMPAAVPAIGPAAVPVSGYVPPLSTLNLSDPAVANAFMAQYRAQSQPQQLFGGAKPVEKPQPKPRPQPKDKPKSKVAIPGCEPWVLVYTKYGRRFVYNPVKNASYWRIPEKLMPAILEMDKERIRKKAEGDQEGGKKEEEEEKEKETSRAPEDSKQSEKRKESEAPSEQPPQRDYDSSEYEEVEVTDDEDEAADQQDQSGPPEFTEADIATQLALMNAEYGEQGDYEAGEEGQWEEGDEGLPLSEEDARALFKDLLNDFHINPYSPWEKLMEEGKIFDDARYTVLPTTKARKEVWEEWSREKIAQLKEQRAKQEKQDPRIAFLAFLQEKATPKLYWPEFKRKYRKEGPMRDTSLSDKEREKFYREHINRLKMPQSQLKTDLKKLLQSVPLSQLNNQTLSSHLPSQVLADIRYISLPPEVRDPLIEAYIKELGPPPEASENAEDEAARQAREERRKRHEKALQERERAVAEEKKRQERKLQIERERLREEERELERAMHVSKKGLQTQLLGDQMVKEDREKMETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8E9</accession>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="30840at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004059">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051635">
        <property type="entry name" value="SNAT-like"/>
    </dbReference>
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        <property type="entry name" value="SEROTONIN N-ACETYLTRANSFERASE"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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            <begin position="183"/>
            <end position="332"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS21123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="342" mass="36689" checksum="3FE58F24C5507BD9" modified="2011-10-19" version="1">MVVSDSPAAATASEAGDSARASNSSINLSAAPTFPHETPHCPGHDVTTAPDSETNNVNTAVVPDLTATTDPDSDAVDETSDVDGDFATLQKMLSQKRRAAKDSPEARLQKALPFVPTFAPNIRPLTIADVDACVALENAAFPNPEHRATRDKFEYRLTVCPELSLGVFITIVPSQAHSFFGDATTAAEKLETLPYARPVETDRADGAVSLLLAHIVSTRCRGAIITDADMAVPDGWRSLNGKSTEVGHQETAGTVGLHSLAVLPRLQRCGIGQLIMKAFLDQMRNMGLVERVALICQENLISYYERTGFKHAGESRVRYGGGGWHDMVYDLPRQPAKPGLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8H0</accession>
    <name>G0S8H0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Nitrate reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CTHT_0029850</name>
    </gene>
    <organism evidence="23">
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        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 17">Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>nitrite + NADP(+) + H2O = nitrate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19061"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
        <text evidence="18">Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the nitrate reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006693377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8H0"/>
    <dbReference type="STRING" id="759272.G0S8H0"/>
    <dbReference type="GeneID" id="18257023"/>
    <dbReference type="KEGG" id="cthr:CTHT_0029850"/>
    <dbReference type="eggNOG" id="KOG0534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_4_0_1"/>
    <dbReference type="OMA" id="KAMMPDY"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050464">
        <property type="term" value="F:nitrate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006809">
        <property type="term" value="P:nitric oxide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000016">
        <property type="entry name" value="Nitrate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.420.10:FF:000005">
        <property type="entry name" value="Nitrate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012137">
        <property type="entry name" value="Nitr_rd_NADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022407">
        <property type="entry name" value="OxRdtase_Mopterin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF7">
        <property type="entry name" value="SULFITE OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000233">
        <property type="entry name" value="Nitr_rd_NADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00559">
        <property type="entry name" value="MOLYBDOPTERIN_EUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="9 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 18" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="14 17" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="20">
        <location>
            <begin position="542"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="21">
        <location>
            <begin position="642"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="25"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR000233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EGS21144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="871" mass="96525" checksum="6EDFC0E566EFB0E5" modified="2011-10-19" version="1">MDSSLDLQPLSEAVAQSLSSLSLSSLATSNSLDSDPSPSSTPATSGTSTPFEPPEPRKVLYPLPPQSRPLQVLPEDLKTPDSHVPRDPRLIRLTGIHPFNVEAPLTDLFNAGFLTPTSLHYVRNHGAVPFVPDSSILDWEVTVEGMVQHPMKLTLRELLDEFEQVTYPVTLVCAGNRRKEQNVVRKTKGFSWGAAGVSTALWTGVPLVEVLARAKPLRGARYVCFEGADALPNGHYGTSVRLSWAMDRQRGMLLAHGMNGEVLHPDHGKPLRVVIPGQIGGRSVKWLKRIIVTAQPSDNWYHIYDNRVLPTTIDPEQSANVPDVWRDERYAIYDLNTNSAVCVPAHEQRVTLAQQDGAFTLRGYAYAGGGRRVTRLEVTLDQGRSWKLAEIDYPEDAYRAVPDGETLFGGRIDVAARDTSFCWCFWRLALPLSELAAAGDVMVRAMDEALHVQPRDMYWSVLGMMNNPWYRVVIHREGDSLWFEHPVQPALMPGGWMERVKREGGDLANGFWGEKVPGSGGNGKIEEEKLVKEISMVNPDVKREITLEELHQHSGEEEPWFVVKGQVYDGTPFLRGHPGGAASIIHAAGQDVSEEFLAIHSENAKAMLPQYHIGYLSPSLSALSLPPSMSPSTPQTTFLSPTFWSHLILHSKTPISPDSTIFTFHFPPSHSHLPLGLPAGKHLLLRLRDPATREPIIRAYTPLSPSHNIGEVQILIKIYRPDAKKGYPTGGRMTTALESLPLGHPVETKGPVGGFEYRGRGRCVVHEAERRVKRLVMLAGGSGITPMWAVLRFVVEGMRRGEGGKRESEPESEPEPEPECVLVYANRTEGDILLRQALTQLEEQSRGRCRVVHILTQPGETWRGLKGEDKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8N0</accession>
    <name>G0S8N0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0038670</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694286.1">
        <property type="nucleotide sequence ID" value="XM_006694223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8N0"/>
    <dbReference type="STRING" id="759272.G0S8N0"/>
    <dbReference type="GeneID" id="18257905"/>
    <dbReference type="KEGG" id="cthr:CTHT_0038670"/>
    <dbReference type="eggNOG" id="KOG0835">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022000_5_0_1"/>
    <dbReference type="OMA" id="WEDVWSV"/>
    <dbReference type="OrthoDB" id="10264655at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS21990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="34445" checksum="D44406A965429C41" modified="2011-10-19" version="1">MSLLANPLVTSEQLFQRRSVGALPIEIQDAIFFATQSLTQAAGILLELPQSVTAQANVLLARYWLVENMMADEFSVRTLLPLLPPSPEANRSQDVSAAILYLTAKLSSHPRSPRELSAIYSYLLSKSSPFFRTQQLQNLPKYVPPPESHYQSFRPRLLTLESRILAALSFNTHVALPHPLAITYLQSLDFFCHPRREALARRTIAYLNTALLSPQLLYTTHQPHALAVAAIYCAARDLGAKMPECEWWEVFDVEREELGFLVVGMRSVEGWARERLMVEVPTSEGGMITRGDVERVLREREEKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8P3</accession>
    <name>G0S8P3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Serine-type endopeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CTHT_0039850</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9 10">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988042">
        <property type="protein sequence ID" value="EGS20246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694395.1">
        <property type="nucleotide sequence ID" value="XM_006694332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8P3"/>
    <dbReference type="STRING" id="759272.G0S8P3"/>
    <dbReference type="GeneID" id="18258023"/>
    <dbReference type="KEGG" id="cthr:CTHT_0039850"/>
    <dbReference type="eggNOG" id="KOG3525">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003559_3_1_1"/>
    <dbReference type="OMA" id="RVKFDYD"/>
    <dbReference type="OrthoDB" id="10256524at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02124">
        <property type="entry name" value="PA_PoS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07489">
        <property type="entry name" value="Peptidases_S8_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010435">
        <property type="entry name" value="C5a/SBT2-like_Fn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054399">
        <property type="entry name" value="Fervidolysin-like_N_prodom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034187">
        <property type="entry name" value="Peptidases_S8_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF66">
        <property type="entry name" value="SERIN ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22148">
        <property type="entry name" value="Fervidolysin_NPro-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06280">
        <property type="entry name" value="fn3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="6 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9 10" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 9 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409022" evidence="11">
        <location>
            <begin position="17"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="domain" description="Fervidolysin-like N-terminal prodomain" evidence="15">
        <location>
            <begin position="23"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="12">
        <location>
            <begin position="152"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="13">
        <location>
            <begin position="373"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="12">
        <location>
            <begin position="468"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="C5a peptidase/Subtilisin-like protease SBT2-like Fn3-like" evidence="14">
        <location>
            <begin position="614"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8 9">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8 9">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8 9">
        <location>
            <position position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF06280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF22148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGS20246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="919" mass="97827" checksum="6933467CF523E11D" modified="2011-10-19" version="1">MVRLTSLLAAAGIARAAVASSSTTAPAAPEIVPGAYIVEYEGDQDTNAFVKELGGEASLRKDLRFKLFKGASIQFKDTKNAEKLAAELADLPKVKNVFPVRRYPLPRHTIHSVGSTVANIAESLKKRDNGTDTFSTHLMTQVNKFHDAGITGQGIKIAVIDTGIDYRHPALGGCFGPGCLVSYGSDLVGDDFNGKNTPVPDPDPVDSCNGHGTHVAGIIAAQSNNPYGIIGAAQGVTLGAYRVFGCDGDVGNDVLIAAYLMAYEAGSDIITASIGGPSGWGEDPWAAVVSRIVEAGVPCVVSAGNDGATGIFYASTAANGKKVTAIASIDNTETPALLSNASYTVAGGPATAFGFTAGEPGEWPDVTLPLWTVNYNTSDPAHGCDPYPDDTPDLSDRIVLIRRGTCTFVQKITNAVAKGAKYVLFYNNVAGTVTVSGKVDGVEAVAMVTAKQGEEWVRAMEAGQEVVVTMTDPSKAGKFLTVFENTATPGYMSEFTSWGPTFEVDVKPQFGAPGGMILSTYPIHMGAYAVLSGTSMSCPMAAAIYALLMNVRGTKDPKTLENVLSATAKPNFFRSGGQTPEPPLLAPVVQQGAGILQAWDAAHATTLLSVSSLSFNDTEHFVPYHHFSVSNTGKSEVTYKLGNVGAATAYTFAEATDITPMKFPGEITADFASLAFEPAEFTLAPGQRKVIKVTATPPKGVDVDRLPVWSGYVTINGTDGSNLSLPYVGVSGSLKAHTVLDERKTYLSRGSDEDNTPILSNDVTFLLPPQGFANDTRYRNGTELPKLVATLSFGSPLVRVDVVPLSNCTSVKEKATLVFGDTLSLGQPEGLPSLWNPRGTVELKWDGRLADGTYAPAGKYKLVVRALRVFGNPDEKGDYDVTETVEFKVRYKKTEEEKKLRRLRRRAEKRRLREMLNRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8R2</accession>
    <name>G0S8R2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ATPase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0040040</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988042">
        <property type="protein sequence ID" value="EGS20265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694414.1">
        <property type="nucleotide sequence ID" value="XM_006694351.1"/>
    </dbReference>
    <dbReference type="GeneID" id="18258042"/>
    <dbReference type="KEGG" id="cthr:CTHT_0040040"/>
    <dbReference type="eggNOG" id="KOG0065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_35_0_1"/>
    <dbReference type="OMA" id="RMNLINP"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001465">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="488"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="523"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="556"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="662"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1081"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1105"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1147"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1189"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1217"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1250"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="61"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="740"/>
            <end position="984"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS20265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1379" mass="151915" checksum="11C3F3759EFEB993" modified="2011-10-19" version="1">MSSPASSFHLDTSELKADLNIASLGLEPRRLGVSWKDLTVTADATNATIHNNFFSQYNIFQKLRDSRRKPPVKTILDNSHGCVKPGEMLLVLGRPGSGCTTLLSVLANRRRGCASVTGDVWYGSMSAAEAEQYRGQIVMNTEEELFFPSLTVTQTIDFATRLKVPANEGVSQEELRQKMQDFLLKSMGMSHTRNTKLGNEFIRGVSGGERKRVSIIECLSTRGAVFCWDNSTRGLDASTALEWAKAIRTLTDTLGLATIATLYQAGNAIYHLFDKVLLLDGGKQIFYGPIKDARPFMESLGFACQEGANVADFLTGVTVPTERRIRPGYELTFPRTAEEVKEAYEKSSIYGRMRRECDYPFTEEARENTARFKQTVAAEKHTQLPRDSPLTVSFTEQVKACVMRQYQIVWGDKTSFLVKQLFTIMQALVMGSLFYNAPDNSSGLFGKSGALFFSLLYNALLSMTEVSNSFSGRSILIKHRYFALHHPAAFCVAQIAADIPLVFFQISVFSVIMYFLVGLEASAGVFFTYWLILAVTTVCMTALFRAIGASFSAFDGAAKMAGLTITSAMMYTGYMVQKPQMHPWFVWIYWINPLAYAFDALLSNEFHGKIIPCVGNNLVPNGPGYSDAARQSCAGVPGAVQGQTFLTGDQYLAALTYSHTHIWRNVGIIVAFWALFVIWTVISTSRWRAPTEGGSTLLIPRECSKPLKQDEEAPAEKSPITHSRAQLTSHNQLLRTTSLLTFQSLSYILKSPHGDGDLTLLSNIQGWVKPGMLGALMGASGAGKTTLLDVLAQRKTDGVVTGSILVDGRPLPLAFARSAGYCEQLDVHEPWVTVREALEFSALTRQGRNVSRKEKLEYVERVIELLELQDLADTLIGTPGNGLSVEQRKRVTIGVELVAKPSIVLFLDEPTSGLDGQAAYNTVRFLRKLADAGQAVLVTIHQPSAQVFGLFDALLLLAPGGRTAFFGEMGPNGSRVRDYFARYGAPCPEDANLAEHIIDVVSGRPPSQGKDWAETWLSSPEHAAVTRELDTLIATAAAKPPQPLPDDSHEYALPLWEQIKLVTSRTSLSLYRNTPHLNNKLMMHLVCALFNGFTFFQIGDSLSDLQLRVFSVFNFVFVAPGVINQMQPLFLQRRALFEGREHKSRMYSTIAFVTAVIVAEIPYLILCGVVYFTAWYFTAGFPISPSRSLATLLTMLLFELVYTGIGQFEAAAAPNELFAALTNPVVLGLLISFCGVLVPYAQMASFWKHWMYWINPFTYLVGAMMVFGLWKQEVMCKPEELAVLKAPGNLTCGEYLAGYLKGMGTGARLLDPDAVGECRVTFDRADAVSVAKNTRGQDKLAKAQRRQAKPTNAGGLTLARSSDVGGPLFIVSVLPFEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-12-14" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9J2</accession>
    <name>G0S9J2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0046080</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694988.1">
        <property type="nucleotide sequence ID" value="XM_006694925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9J2"/>
    <dbReference type="GeneID" id="18258646"/>
    <dbReference type="KEGG" id="cthr:CTHT_0046080"/>
    <dbReference type="HOGENOM" id="CLU_2440652_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="90" mass="10277" checksum="94914AFBEF1F6FEF" modified="2011-10-19" version="1">MASTPVINNAGRVQKPKRKRPATTKVILDTPIIKVIRPGFWSPRAFYANRDHHLELPSYKVPVETGHIDLIMDILTREKKAESKESKESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9R3</accession>
    <name>G0S9R3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0046830</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695059.1">
        <property type="nucleotide sequence ID" value="XM_006694996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9R3"/>
    <dbReference type="STRING" id="759272.G0S9R3"/>
    <dbReference type="GeneID" id="18258721"/>
    <dbReference type="KEGG" id="cthr:CTHT_0046830"/>
    <dbReference type="eggNOG" id="ENOG502RJF6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066466_0_1_1"/>
    <dbReference type="OMA" id="FNAEWIV"/>
    <dbReference type="OrthoDB" id="2862635at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070007">
        <property type="term" value="F:glutamic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13426">
        <property type="entry name" value="Peptidase_G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.700">
        <property type="entry name" value="Peptidase G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000250">
        <property type="entry name" value="Peptidase_G1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038656">
        <property type="entry name" value="Peptidase_G1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536:SF1">
        <property type="entry name" value="ASPERGILLOPEPSIN, PUTAITVE (AFU_ORTHOLOGUE AFUA_7G01200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01828">
        <property type="entry name" value="Peptidase_A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00977">
        <property type="entry name" value="SCYTLDPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="261" mass="28747" checksum="82B7218E760E4AA6" modified="2011-10-19" version="1">MRWQTLLPLFSFPGPSFSELTFTTVHTTGGKLVSASGLPTLKNLRANNPTVNSNNWCGSVNYAPIGRQIRLVHGYFQHPVCEIRNGMKTFPQAVAAWVGIDGDTWTDSLLQAGTVCKIDNSSGVVTNEAWWQWVPSGAYTISTLPVAEDDWFEVTINTTSPSSGEITITNLSQRYTYSVTLSGGPTLARVDADWVVERPYFGKTLSGFATFTDVWFEDTYAELLPGTGTIGVLGANQYQIPGMCTSMEWDDRHLVSWSLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9S7</accession>
    <name>G0S9S7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyltransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0047020</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695073.1">
        <property type="nucleotide sequence ID" value="XM_006695010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9S7"/>
    <dbReference type="GeneID" id="18258740"/>
    <dbReference type="KEGG" id="cthr:CTHT_0047020"/>
    <dbReference type="eggNOG" id="KOG1269">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057148_1_0_1"/>
    <dbReference type="OMA" id="LSFGTWC"/>
    <dbReference type="OrthoDB" id="10017101at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003838">
        <property type="term" value="F:sterol 24-C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF1">
        <property type="entry name" value="HYPOTHETICAL LOC100005854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="3">
        <location>
            <begin position="48"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS20188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="279" mass="31356" checksum="49B00630BB058078" modified="2011-10-19" version="1">MPPIYHHGHAPSQTLHHSWRTVTNSAPHLLPHLARLSSTSSSFPIRVLDIGCGPGTLSASLAKHLPPTARIVATDISDDVLARAREHAVREGLAEMMEFVNADVCYLPFKDGEFEVVHAHQVLCHIEDPVKAIKEMVRVVKKEGGIISLREADVRNWHCWPELEGLRKMEMLMREVMKADGGHPEAGMRLVEWCVKAGVKKSRIDMGFGSWCFAKEEDRRMWGMAMIERLKAGHLRRKSLELGITTEEEIEGIIRDWESFMATETATLGNVNGEVTIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0SA18</accession>
    <name>G0SA18_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative dihydrodipicolinate protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0040680</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694475.1">
        <property type="nucleotide sequence ID" value="XM_006694412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SA18"/>
    <dbReference type="STRING" id="759272.G0SA18"/>
    <dbReference type="GeneID" id="18258106"/>
    <dbReference type="KEGG" id="cthr:CTHT_0040680"/>
    <dbReference type="eggNOG" id="ENOG502QWNS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049343_0_2_1"/>
    <dbReference type="OMA" id="IAPKACI"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF52">
        <property type="entry name" value="4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS19590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="377" mass="39807" checksum="53D5965DE63CC763" modified="2011-10-19" version="1">MAPHSDAPSPTGSFTAGFNRIPPFQDVATPALHISTLEPHSPLSSSYSSSTSEPSGFHITRPLVPGVYVPTLCFFEEGTEDLDLDTIARHAVRLARAGVTGLCTQGSNGEAVHLTHAERRLVTATTRKALNDAGFAHMPLIVGCGAQSTRETIQHCREAWEAGGDYALVLPPSYYASLFAPASGTVFDFFTAVADASPIPIIIYNYPGGAGGLDLSSDVIIKLSEHPNIVGVKLTCGNTGKLNRVAAATRAAAGKSYNPEKPDFLVLAGSADFTMQALIAGGHGILAGLANIAPRACVRIIELYHQGRIAEAQALQEVVARGDWTAIQGGVVGCKSGMQGWMGYGGYARSPLPKPTPEQARAWKEGFRELVLLEKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAA7</accession>
    <name>G0SAA7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0041600</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694564.1">
        <property type="nucleotide sequence ID" value="XM_006694501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAA7"/>
    <dbReference type="GeneID" id="18258198"/>
    <dbReference type="KEGG" id="cthr:CTHT_0041600"/>
    <dbReference type="eggNOG" id="ENOG502SY30">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_21_0_1"/>
    <dbReference type="OMA" id="FMYGHGF"/>
    <dbReference type="OrthoDB" id="4181370at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36503:SF2">
        <property type="entry name" value="BLR2408 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36503">
        <property type="entry name" value="BLR2520 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="7"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="154" mass="17208" checksum="8621B454C83FD654" modified="2011-10-19" version="1">MSTTTAPPTFIISVPTTDIPSAKSFYTSLNFHFLPDWSDASSISFILPSPNNNIALMLHTHDRVKKFFRPGAIIADPKTTNEALFSISVKKPEEVDEWLDKAVKAGGEKDPFVMKEYGKDMGMYSRSFADPDGHIWEVMCWVAKCGQTGEVRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAI2</accession>
    <name>G0SAI2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0042380</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694639.1">
        <property type="nucleotide sequence ID" value="XM_006694576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAI2"/>
    <dbReference type="STRING" id="759272.G0SAI2"/>
    <dbReference type="GeneID" id="18258276"/>
    <dbReference type="KEGG" id="cthr:CTHT_0042380"/>
    <dbReference type="eggNOG" id="ENOG502QRPI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015980_0_0_1"/>
    <dbReference type="OMA" id="CKNPRHL"/>
    <dbReference type="OrthoDB" id="992776at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46100">
        <property type="entry name" value="IMP2'P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46100:SF4">
        <property type="entry name" value="USPA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="616"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="713"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="579"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="713"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="723"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS19754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="744" mass="80430" checksum="640C7B0ADBA15AB3" modified="2011-10-19" version="1">MSRRPPMSMEASLEEERREVLALLEGRSSSPRPFGARSPSPYTTPRSPVRSMLDIGEPPRSQTPPQSLSAKTIPVRAAPVRSMLDVDAPPVQPVRSMLDVDSPPPAVSKVQSQPTSPTDSSPRTHTTHGTHPRSMSEVSTRPNDFGSRMSVQQPDPLSEYQFSGIITTGVGQPLPKRVTQGDRRASDIPKINDIPSLVVVGDRGRLHSASGPSLRATKSKSPHNRFSLRSHSPAAPILGRHLSPAGRKFLQETHEIDYNLAYTRLSDAALARSGGSLSELGRKKSEDAEGTGRLAKDYLSPDGDILPEESSDESDRSSGEENERGRKASRSIDKLPTEGSKSASGEGKRQAQTLLQAAEDERLQVVATQQPTYQYRSLLDDPKITVANPSGERIKHSKPHVHPATSFDNPPGSGTQTPMDSDTEADLSDIKQAQNLSFAMTQIIDTPEAHRTIQIITRGEYEKLAKEAEEEHRPPRKYLVATDLSEESTHALEWAIGTVLRDGDTLLAIYCVDEEAGIGGVDASTPGGGQVPDEPKAMKEQAAAINTVTSSTTPISASGTNLPLHTAPGTSKQQGSDGSTSVSPAPSATANGNTDTISGSGTNENGNRDQSQPPRKERSRAEEERYRAVGEISSRVLRLLRKTRLQVRVIVEVLHCKNPKHLITEVIDLVNPTLVILGSRGRSALKGVILGSFSNYLVTKSSVPVMVARKRLRKQGKNKRLPSTHQVNNINNPAARSLANAKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAQ7</accession>
    <name>G0SAQ7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0043140</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694714.1">
        <property type="nucleotide sequence ID" value="XM_006694651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAQ7"/>
    <dbReference type="GeneID" id="18258352"/>
    <dbReference type="KEGG" id="cthr:CTHT_0043140"/>
    <dbReference type="HOGENOM" id="CLU_612496_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="447" mass="50403" checksum="94ACA6372B8C8522" modified="2011-10-19" version="1">MSSGNPIPPIYYTPNPQSHPDTACSPATEPPSGSEQTSSATASRSNLSRSTTILGGENDFKTAAAAVAKQPSQQQQEGLIPWHEQEVTNELEGWEREHGKGWGEGRGEPMDVDGRKPPQGQAWVAGDGGGGGQHFQQRMGYGGWQGQQQQQQQQQQPVMGVHQASCSTGWYGQEQQQIWPQCHNSAYQHQQPHLHPQVLRQQRAQFTPPQHPQLHQQPFQQQQPFHNAHRLSHSRQPAAPHSHHQHTHALYPQQLQQSYAIHHPQSQQPLPLLALLQQLADNALNIVDQAESQGNDSDSEANNGPSSGVRKIQVVLSPNNSNPPQIATRYPDSDTEDNFSYDPYDPYCPYGDEDGDDWKEAKQVRSQEGRRKLRKKVGAMYVVVVDNRRKDQDQRKKRRRKLEATEEEDQDEDWRERRTGGYQRGKGKKGRGKGNWHGERARNTRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0SB42</accession>
    <name>G0SB42_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">CDP-diacylglycerol--serine O-phosphatidyltransferase</fullName>
            <ecNumber evidence="5 18">2.7.8.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 18">Phosphatidylserine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CTHT_0048810</name>
    </gene>
    <organism evidence="23">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16913"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="17 18">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18 19">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.8" evidence="5 18"/>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695244.1">
        <property type="nucleotide sequence ID" value="XM_006695181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SB42"/>
    <dbReference type="STRING" id="759272.G0SB42"/>
    <dbReference type="GeneID" id="18258919"/>
    <dbReference type="KEGG" id="cthr:CTHT_0048810"/>
    <dbReference type="eggNOG" id="ENOG502QPJG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049944_5_1_1"/>
    <dbReference type="OMA" id="HGCGMIS"/>
    <dbReference type="OrthoDB" id="448573at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003882">
        <property type="term" value="F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006659">
        <property type="term" value="P:phosphatidylserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000022">
        <property type="entry name" value="CDP-diacylglycerol--serine O-phosphatidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004533">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016271">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00473">
        <property type="entry name" value="pssA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF61">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000852">
        <property type="entry name" value="Phosphatidylserine_synth_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 18 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="14 18" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 18 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR000852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EGS19422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="252" mass="27037" checksum="76F9DB8AB36A2561" modified="2011-10-19" version="1">MSKRNSVAAANGAASSSRETAVASPSPPASFPAVDNKQKLLLSSDSGHFSLIRALHLADYITELNGLCGILSVFSSMRYCLGDPSSHGNLWTALSLLPFAFFFDFLDGRVARWRKKSSMMGQELDSLADLISFGVAPATIAFAIGIRTPLDHLCLGFFVLCGLTRLARFNVTATAIPKDASGKVKYFEGTPIPTTLALDALMALWISRGQIHDSLPGGVWLAGSVLEVHPAVLLFMVHGCLMTSRTIRIPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0SB93</accession>
    <name>G0SB93_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0049370</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695295.1">
        <property type="nucleotide sequence ID" value="XM_006695232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SB93"/>
    <dbReference type="STRING" id="759272.G0SB93"/>
    <dbReference type="GeneID" id="18258975"/>
    <dbReference type="KEGG" id="cthr:CTHT_0049370"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_4_1"/>
    <dbReference type="OMA" id="ICTFRGV"/>
    <dbReference type="OrthoDB" id="9930022at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C1773.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="18"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="346" mass="37134" checksum="8E127D7658A474AB" modified="2011-10-19" version="1">MALPTTQKQWLIQGTGKGFETLVYQDAPVPQPGDNDVLVKLQGASINYRDLIIPQGKYPFPLNLPIVAGSDGAGTVVAVGRNVTKWKPGDKVLTLFNQGHQSGAVDVKAAHTGLGGCIDGTLRQYGVFNENGVVAMPKNLDFVEAASLACAALTSWNALYGLKRLEKGQTVLVQGTGGVSLFALQFAKAAGATVIATTSTAEKAEVLKNLGADHVINYREDPNWGETARKLTPGEEGVDHIIEVGGEGTMTQSLKAIKMEGVISIIGFLGGAHPKDSILEALSHVCVIRGVYVGSRVQLEEMCKEIEKHDIHPVIDKTVFTLEKAKEAYEYMWAQKHFGKIGIKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBA4</accession>
    <name>G0SBA4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dehydrogenase FUB6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Fusaric acid biosynthesis protein 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0049510</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695306.1">
        <property type="nucleotide sequence ID" value="XM_006695243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBA4"/>
    <dbReference type="STRING" id="759272.G0SBA4"/>
    <dbReference type="GeneID" id="18258989"/>
    <dbReference type="KEGG" id="cthr:CTHT_0049510"/>
    <dbReference type="eggNOG" id="KOG1196">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_29_1_1"/>
    <dbReference type="OMA" id="WMSDIPQ"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF7">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="22"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00069006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00083301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS19484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="359" mass="38787" checksum="9CAE4C300DE98317" modified="2011-10-19" version="1">MPTYTNKTLVFAAIPDALPVAGEHLVIEDRGPFDPATPPPPGGLTLSVLYTSFDPYQRGRMRPAHVKSYSPAFELGGPITNDSVARVIKSDAEGFKEGDLIVAHLPTAEWAVLTAEQVKSQVRKIDVEKTPKELLSNLGLFLGPLGMPGLTAWSSLYEIGQPKKGETIFISSAAGAVGQVVGQVAKKEGLRVIGSVGSDEKAKFVMEELGFDGVFNYKTERTKDALKRLAPEGLDIYYDNVGGEQLEAALNAMKPFGRIVACGMISQYNLPESERSGPKNIFLMVTKRLTMRGFIVSDPGFGDKYAQDHQTKLGQWLAEGSVKARLSITEGIDNAAEGLIGMLQGKNFGKAVLKIKNED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBP0</accession>
    <name>G0SBP0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0054260</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695761.1">
        <property type="nucleotide sequence ID" value="XM_006695698.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0SBP0"/>
    <dbReference type="GeneID" id="18259464"/>
    <dbReference type="KEGG" id="cthr:CTHT_0054260"/>
    <dbReference type="eggNOG" id="ENOG502QQV3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_235350_0_0_1"/>
    <dbReference type="OrthoDB" id="5144858at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1039"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1084"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1328"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1486"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1672"/>
            <end position="1692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1711"/>
            <end position="1777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1871"/>
            <end position="1899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="661"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="720"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="744"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="798"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1722"/>
            <end position="1744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1871"/>
            <end position="1886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1887"/>
            <end position="1897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1922" mass="205944" checksum="10DAF170706111FB" modified="2011-10-19" version="1">MAWWDSKHRAAGPSPSLPPPIRPRDSRQRLVMGDVFPRLDQGTLYKIDTEQERERAMLPPVLEVQRPGLPTTPALVVHVEIRFTDPVIRSRYSRTYASSPGFAATNRICRGLIRRIERCSQELLTRKDSSALDMFKAGSGERKPQRFEMNFRIMRRDRDKGDKTECAERTYRSYQKQPLTVALAKEVVTATHRMVGLFMRRHDDKFRWVDCPFPDSDPQAESLEVTGGGPPTLLCVPNSRFNEATQKFEFTPGYSIDLFFRSRSHHRPALPTYDKRLRISSTQTTPLTLQMTDDLLWRVLEAINQGLELKKREHDEHLRNRVGFGHSRDDALEIAVRIKNNLGPIFTHAQRQVKSKLGLFRDPRAADCEDFLRSMEHYLSHARNQTDKKINALNDLDFRVVELKGVNWNIREPLKFTIGPSASYGRRTIGAALERIQTGIGDVIRGHNVAIHIQAHKRGHLILDKAIVAHEKRGRPKEYFATPDEAMNAFVSRLKHRIQQDIDMVFEDTCAIDDLPENDEDHIMQPVTSLGADRGLFGEAAFSSIFMPPSPSSSPTRKSRTTTGAGSLRSEQTSFSRPSLESVQSFDYLWQQNEDLFTGSNSRPSSGHSIEAPSASTSNGRPDWRSYWNAYQRPRGNDRFSLLSQGDSIPAKRSFSLAPKRSSTTARTSNASNLVDDTRSIAASEQSRDEGDQVAGRPASRLSSREQESPSASFIRRSIDSNSVRSAGVSSQNSSQDEGGKPITSVSHENIAAPSQESPILPPEEGMEEPEPFREFAVGNTSVRSDETRLATPELSDGASTSRKSPLSTPSSLRTASVSQPAILQSPTKFETHVPGVVPGEPALKGENEPFALNGQIHKPVQMVQSTPNIVPAQTPDDLQNATVDVTTRDTQEGSNPGPVVMLHQQATCPELASTIQQAALPLNNILCNSDAVEMKQSKRKAVTESLGAEINSISDVPCPLATDFPTTEVRRPENNEAAQVLVHHLEHNSKQDVSTSDIASQSRVELHFRDATGDNLGAGSGAEVKPVGDHVTKGVSADDAPGAVLFTNPEQIPSTEPVRRPSRTRSMSESIVQATEALAELVDQEQEDGTQVSSAETDPGTANKGSDDVATITAAATVGSKLATEAQGNEPSLPVVHDVSTANTAEISVAQGQLPETVAQGQPAAKPHAAGNTCAVPLSNVAAPESSETIKEQTQGDALIKLSSDKADMARAVQDAATATATAAMPAAALEQRSNENERVAVVGAGNETVEVAQVQTVGRELDCGNMPGCDLASEESAMASVTTEVPVRSHVSETSLTAGPKVVDAIKETAPDVNMHSERGVAVAEKSCSAPEPDVKEPKGSAAPLQDGVTGTESHPEDVVGQKEHIVLSEVVGWGLSKKEQAHKMLSDSVPELRGLEPDVTAAVARASADSVADVVAGPEGSVRSAVAAEHGTEQRSEKTSAAVPAAITAADAESEETKEKENITEQAAARTADVVTLATHLAEETTERVNTPPVLTPPGSADAKTGSTSTEKGIADELADRTALPPPVVPEAKTEVGAGATEAVGAAAADVEVKVQANDFLQEAVCIGVVSEPLVHEPAEELKVQVKDDKQVVEVAEVVAVELVAKPEGCEALDKEVGANTESCLDHAVSPAISAEPSTSQASGISIASAEAENNTHVAASVTPKPSAVLPAAEAPQPPSAEPEVEGKPQLAAVPDPALLSRLLAQEADESDVDEGATARSTLSATSIPPTPRNSVDSVRLSTGLDDEEASFAIPATPESVRPKSRDSDSSGVSFRRVGLQPAFTTAGLLGLRDLQHRHGQHQAHNVSSLSVNTLVRGGGSTGSLVSGRVFGDVLQAVVKRETLVATSVTSSDKGSELDLEEAKEIEGKRAVAEKQKTAREGQVDEDGEDEMTADEGMLPKMALVIAGAMAIGKFFAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBS3</accession>
    <name>G0SBS3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0054600</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695794.1">
        <property type="nucleotide sequence ID" value="XM_006695731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBS3"/>
    <dbReference type="STRING" id="759272.G0SBS3"/>
    <dbReference type="GeneID" id="18259498"/>
    <dbReference type="KEGG" id="cthr:CTHT_0054600"/>
    <dbReference type="eggNOG" id="ENOG502S08D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012261_0_0_1"/>
    <dbReference type="OMA" id="QILNMPF"/>
    <dbReference type="OrthoDB" id="419770at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="457"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="540"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="597"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="676" mass="73364" checksum="6EC0CBC9AC1220AC" modified="2011-10-19" version="1">MANQLSGHSSLPRGFRYSGLDEPPKTPEPLLQSDEAQLPSPPRPRLRVRRRVASQLSAPTQQFLASVAAADIPIPSIEEPEPEILPRRFHMDDDLIPFPELPIETQCEGYLQVPRARPSSPKTPAPELEQARPRKRYPSWSLDLSSSVESTPEPDYESSRPSTSRSTHTSASLFSQFSQFSDEECSEESDGEGTFYTCPLADEEDEEPAETTPQASSSASKTKRGRKAPWTKAMSDHLWSTFLLYLQDPRVTPFRMSKSGIPPDGVCLRVARAAKKSWKGSRAMARAAKASAEGKKSGSATPTADNSSPFIEWPHTCAATRAHLRELCRLKASSRPSTFRFMSRTGTPFTQAAARHWNRRSTPARGEGAFTTRDISVSLALSTAESMQPNGPLAQLAKAGSGPSITRPEPELKLQPEPTPASTVDRSEPSLDSSAGKKILQTFEGEPSFAERRRLGSPFTPSSYGPSSSNSLAAILGLSGSAMPRRQSQSLGSRKTLQSPVRLSRSGAQKRRHTQSGVFRKRPSIGADWWLDPSLANSTAETASSSSTEAGATTRVRDDGIFIPKPASGPPLNTSASMPDVSVKSDTSSLEPPPRLGSPFSVSSSSHSYPHRAHRSHQAGSIDLGVLGRPFATIQPFSSDSNALSGRQTTLADRLAYLDQRLKELNQKGTNARSEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBW4</accession>
    <name>G0SBW4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Actin-related protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0055020</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="15 16 17" key="2">
        <citation type="journal article" date="2022" name="Sci. Adv." volume="8" first="eadd3189" last="eadd3189">
            <title>Structural mechanism of extranucleosomal DNA readout by the INO80 complex.</title>
            <authorList>
                <person name="Kunert F."/>
                <person name="Metzner F.J."/>
                <person name="Jung J."/>
                <person name="Hopfler M."/>
                <person name="Woike S."/>
                <person name="Schall K."/>
                <person name="Kostrewa D."/>
                <person name="Moldt M."/>
                <person name="Chen J.X."/>
                <person name="Bantele S."/>
                <person name="Pfander B."/>
                <person name="Eustermann S."/>
                <person name="Hopfner K.P."/>
            </authorList>
            <dbReference type="PubMed" id="36490333"/>
            <dbReference type="DOI" id="10.1126/sciadv.add3189"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.90 ANGSTROMS) IN COMPLEX WITH ATP</scope>
    </reference>
    <comment type="subunit">
        <text evidence="10">Component of the NuA4 histone acetyltransferase complex, of the INO80 chromatin remodeling complex, and of the SWR1 chromatin remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the actin family. ARP4 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695835.1">
        <property type="nucleotide sequence ID" value="XM_006695772.1"/>
    </dbReference>
    <dbReference type="PDB" id="8A5D">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="W=1-468"/>
    </dbReference>
    <dbReference type="PDB" id="8A5P">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.40 A"/>
        <property type="chains" value="W=1-468"/>
    </dbReference>
    <dbReference type="PDB" id="8A5Q">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.30 A"/>
        <property type="chains" value="W=1-468"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBW4"/>
    <dbReference type="EMDB" id="EMD-15165"/>
    <dbReference type="EMDB" id="EMD-15180"/>
    <dbReference type="EMDB" id="EMD-15184"/>
    <dbReference type="SMR" id="G0SBW4"/>
    <dbReference type="STRING" id="759272.G0SBW4"/>
    <dbReference type="GeneID" id="18259540"/>
    <dbReference type="KEGG" id="cthr:CTHT_0055020"/>
    <dbReference type="eggNOG" id="KOG0679">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027965_6_2_1"/>
    <dbReference type="OMA" id="MTEAPWN"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13395">
        <property type="entry name" value="ASKHA_NBD_Arp4_ACTL6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000137">
        <property type="entry name" value="Actin-related protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="15 16 17" id="KW-0002">3D-structure</keyword>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="16 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="16 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16 17">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16 17">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16 17">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16 17">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16 17">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16 17">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16 17">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16 17">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16 17">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16 17">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS18890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="8A5D"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="8A5P"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PDB" id="8A5Q"/>
        </source>
    </evidence>
    <sequence length="468" mass="51707" checksum="84639E5109882D24" modified="2011-10-19" version="1">MSQQPLSSSVQPADIYGGDEVSALVLDPGYCNTRAGFAGEEMPKQVIPSFYGHVDGRDLFGDEVIVPRAGFEVRNYMNRDSMVEDWDAATRVWEYLLVQRLQPPRPTPASKNGLNVSDDGDVQMEDSAPNEDALDALEKPLTENPLLMTEAPWNTPKAREKAIEVVMENWGTPAFWLSRTPVLAAFAAGKATALVIDVGGANTSVTAIHDGMVLKRSIQRSPAAGVWLSGQIRSMWKSQDPPVNVVPTFMVENKKPVEAGAPPDCRLRNFGFPIHDSFRAFEEERVLTEFKESVVEVWRGPGKYLNPGNEDFAKTQPGRVFEFPDGSNQMWREQRYRVAEGMWDETAAYPSLNPDEAAITKAQTIPALIKAALDGVDVDLRPNLLGNVVVTGSTSLLNGFNDRLNHELTNMYPGLKIKLHAAGLTSERRFGAWIGGSILASLGTFHQMWISRKEYEENGAGIVEKRCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0SC10</accession>
    <name>G0SC10_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prolyl 4-hydroxylase alpha subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0055490</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695881.1">
        <property type="nucleotide sequence ID" value="XM_006695818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SC10"/>
    <dbReference type="STRING" id="759272.G0SC10"/>
    <dbReference type="GeneID" id="18259587"/>
    <dbReference type="KEGG" id="cthr:CTHT_0055490"/>
    <dbReference type="eggNOG" id="KOG1591">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058132_0_2_1"/>
    <dbReference type="OMA" id="NIWPRRY"/>
    <dbReference type="OrthoDB" id="420380at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF242">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit" evidence="6">
        <location>
            <begin position="84"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS18936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="311" mass="35038" checksum="1B798037D39F3173" modified="2011-10-19" version="1">MASKTQVAGISFGALLLGISIPYLSAITSPFTSLIGDFSVPDHAFSFPFFKSNITTKSLNVTIQPTFVCDPNHTYRTELVSLDPVIIYIHDFITKPEIDALLEVGEPRFKPSQVAKYGVLMNTNDRTSSSAGLPRDDQAVMCVMRRARNFLGTMIRDGWDDMGAPQLVRYREGEKFNHHHDWFENPQMAYDGTSRKWNRVASFFAILQDNCTGGETYFPYAKPIALPGPWGAKMWHGEVRRQKNKTEEVKPLWREHEDGGLAFRPVAGNAIFWINLHANGTGDTRTLHAGLPLDSGLKTAMNIWPKHFYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCB2</accession>
    <name>G0SCB2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CTHT_0056600</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. GCN5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695983.1">
        <property type="nucleotide sequence ID" value="XM_006695920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCB2"/>
    <dbReference type="STRING" id="759272.G0SCB2"/>
    <dbReference type="GeneID" id="18259698"/>
    <dbReference type="KEGG" id="cthr:CTHT_0056600"/>
    <dbReference type="eggNOG" id="KOG1472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015741_1_1_1"/>
    <dbReference type="OMA" id="HQPPKEW"/>
    <dbReference type="OrthoDB" id="1937912at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010484">
        <property type="term" value="F:histone H3 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05509">
        <property type="entry name" value="Bromo_gcn5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000004">
        <property type="entry name" value="Histone acetyltransferase KAT2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037800">
        <property type="entry name" value="GCN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750">
        <property type="entry name" value="GH11602P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750:SF3">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="66"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="14">
        <location>
            <begin position="309"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGS19038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="405" mass="46913" checksum="95AA7B328FFBD92E" modified="2011-10-19" version="1">MTSENGKRKATEEPGSPSAAKRIKQEPSETDKDKKEENKDKKTVAKPPPIPYPEKPAVIEERNGEIEFRVVNNDGERESLIILTGLKCIFQKQLPKMPKDYIARLVYDRTHLSIAIVKKPLEVVGGITYRPFKNRKFAEIVFCAISSDQQVKGYGAHLMSHLKDYVKATTNIEHFLTYADNYAIGYFKKQGFTKEITLDKSVWMGYIKDYEGGTIMQCTMIPRIRYLEQGRMLLKQKECVQAKIRAFSKSHIVHPPPKQWRNGNVTPIDPLSIDAIRESGWSPDMDELARQPRHGPNYNQLLHLLNDMQNHASSWPFLVPVNKDEVVDYYDIIKEPMDLSTMESKLEADQYQTPEDFIRDAKLIFDNCRKYNNENTPYAKSANKLEKFMWQQIRQIPEWSHLEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCH8</accession>
    <name>G0SCH8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Geranylgeranyl transferase type-2 subunit beta</fullName>
            <ecNumber evidence="8">2.5.1.60</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0057280</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="8"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696049.1">
        <property type="nucleotide sequence ID" value="XM_006695986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCH8"/>
    <dbReference type="STRING" id="759272.G0SCH8"/>
    <dbReference type="GeneID" id="18259766"/>
    <dbReference type="KEGG" id="cthr:CTHT_0057280"/>
    <dbReference type="eggNOG" id="KOG0366">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028946_3_0_1"/>
    <dbReference type="OMA" id="VKRCQCP"/>
    <dbReference type="OrthoDB" id="5428259at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02894">
        <property type="entry name" value="GGTase-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000009">
        <property type="entry name" value="Geranylgeranyl transferase type-2 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026873">
        <property type="entry name" value="Ptb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF11">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 8" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="9">
        <location>
            <begin position="14"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS19104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="328" mass="36304" checksum="1F165C755AC8549E" modified="2011-10-19" version="1">MSEDFSDIPEELYLATEAHVKYIQSLDTRKDEYDYWLTEHLRLNGLYWGLTALHLLGHPDALPRADAIDFVLSCQHENGGFGAAPGHDAHMLSTVSAVQILAMLDAFDELEKRGKGKEQVGKYIASLQNRQTGTFAGDEWGEEDTRFLYGAFNALSLLGLLHLVDVDKAVEHIAACANFDGGYGVSPGAESHAGQIFTCVAALTIAGRQDLIDKERLGRWLSERQIAGGGLNGRPEKKEDVCYSWWVLSSLEMIGKTHWINKSQLAAFILRCQDMEKGGISDRPGNMVDVWHTVFGIAGLSLLKYPGLQPVNEVYCMPKSTISRIFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCJ3</accession>
    <name>G0SCJ3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">beta-glucosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0057440</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4 10"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696064.1">
        <property type="nucleotide sequence ID" value="XM_006696001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCJ3"/>
    <dbReference type="STRING" id="759272.G0SCJ3"/>
    <dbReference type="GeneID" id="18259782"/>
    <dbReference type="KEGG" id="cthr:CTHT_0057440"/>
    <dbReference type="eggNOG" id="ENOG502QR4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_4_0_1"/>
    <dbReference type="OMA" id="GCHIYKW"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000114">
        <property type="entry name" value="Glycoside hydrolase family 3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000495">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF3">
        <property type="entry name" value="BETA-GLUCOSIDASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA14" evidence="12">
        <location>
            <begin position="439"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS19119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="882" mass="98095" checksum="76F2A38819C38DF8" modified="2011-10-19" version="1">MAQDIYPNGSPAGSIDANGTTPNTEFSPQDSPVLQYQTLNSKDKKRLLAREKLATLTLEEKISLLTAADFWRTKALPEKDIPAIKTSDGPNGARGSIFVGGTKAALFPCGASLAATWNKELLYQVGQHLAREAKARAANVLLAPTVCMHRHPLGGRNFESFSEDPLLTGKLAAQYIRGLQDGGVAATIKHFVGNEQETNRLTVNSVIAERPLREIYLRPFEIAVREARPWALMASYNAVNGVHADMNTHILRDILRGEWGYDGTVISDWGGMNSTVESLKAGCDIEFPFSTKWRFHKLLDALRAGKITEEDIDRAAENVLTLVERTKGSDLTPEPPEREDDRPETRALIREAGVQGITLLKNDRKLLPLDAATTRVAVIGPNAARAIAGGGGSASLNPYYTTTPLDGIRALAKQPVTYSRGCHIHKWLPVASPLCSDKLGRPGVTIEWFRGDKFEGEPVLVQRRLNTDLFLWDSAPLEKVGPQWSAVVTGYLLPPSSGRHTLSFMSVGPGRLFVDGKLLVDLWEWTEEGEAMFEGSEDVLVQLDMREGRAIELRVEITNELRPRRKQEVFGITHKYGGCRIGFLEEDKVDYFEQAVEAAKQADVAVVVVGLDAEWESEGYDRETMDLPKDGSQDRLIEAVVRANPNTIVVNQSGSPVSMPWADQVPAIIQAWYQGQEAGNALAEVIFGIRNPSGKLPVTFPRRLEDTPAYHNWPGEHNTVMYGEGIFIGYRHYDRTHIPPLFPFGHGLCYTQFEYGRPSVTPKILRECGSLEVIVAVTNIGDREGMETVQFYVRRCDEKGRNKNKVVRPEKELVSFEKVELEPDETKHIRVILDKYAVGYWDVGENRWVAEQGKWEVLVAASAGDVRYSAAFEIKKSFSWVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCS1</accession>
    <name>G0SCS1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7492 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0058220</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696142.1">
        <property type="nucleotide sequence ID" value="XM_006696079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCS1"/>
    <dbReference type="GeneID" id="18259860"/>
    <dbReference type="KEGG" id="cthr:CTHT_0058220"/>
    <dbReference type="eggNOG" id="ENOG502SABV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019095_1_0_1"/>
    <dbReference type="OMA" id="DKMCKDT"/>
    <dbReference type="OrthoDB" id="64281at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055915">
        <property type="entry name" value="DUF7492"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24320">
        <property type="entry name" value="DUF7492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409451" description="DUF7492 domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7492" evidence="2">
        <location>
            <begin position="20"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS19197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="409" mass="44768" checksum="3E7C3F7DA7CC41D7" modified="2011-10-19" version="1">MELSSSKAMLLVAALLGIAAAHSWTEETRRIGPKGDFIGPPGYPRKYAPESRDSYSVWLLPPNGGLNEFTPDLLAVLPTKAGFDESSYHPQYPMLKVAPGDFAAIFYNENGHVSRAGRDNPEKPINRGTVYLYGTTKNDLTGLTLMDVHLKWTADGDINKGRLLATRNYDDGQCHEVLPDTGEADGILTWRKEHITKVEGLRCQSDFQIPKDVKPGSILTVIWVWDWPSMNTVGVAVPPHTFKGKTLSGEKRVSKFELYTSVVDFQIVDPCDPVLGDIKGPTCASVPLNKKNIVRFDRTLPAVNRSIEAQLVHPFMVHVPDFTEDPNLIPLKPLIGAKNPRFPLDSKILDAQYEYFTLGGKAIPTATAIVTATAVATVTAPAGGKNAVVTVTNVVPSATYTTFVTRIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0SD54</accession>
    <name>G0SD54_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0050860</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Conjugated with ATG12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Preautophagosomal structure membrane</location>
            <topology evidence="1 6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ATG5 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18484.1"/>
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    <dbReference type="STRING" id="759272.G0SD54"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
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        <property type="term" value="C:autophagosome"/>
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        <property type="term" value="C:mitochondria-associated endoplasmic reticulum membrane contact site"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:phagophore"/>
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    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.190">
        <property type="entry name" value="Autophagy protein Apg5, helix rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007239">
        <property type="entry name" value="Atg5"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR042526">
        <property type="entry name" value="Atg5_HR"/>
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        <property type="entry name" value="ATG5_UblA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042527">
        <property type="entry name" value="Atg5_UblA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048318">
        <property type="entry name" value="ATG5_UblB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040:SF2">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20637">
        <property type="entry name" value="ATG5_HBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20638">
        <property type="entry name" value="ATG5_UblA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04106">
        <property type="entry name" value="ATG5_UblB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3 6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="4 6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Autophagy protein ATG5 UblA" evidence="10">
        <location>
            <begin position="42"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy protein ATG5 alpha-helical bundle region" evidence="9">
        <location>
            <begin position="126"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy protein ATG5 UblB" evidence="8">
        <location>
            <begin position="187"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS18484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="312" mass="34778" checksum="E661CC8F7265BCA9" modified="2011-10-19" version="1">MASSPTPSLPSPVLGFETSHHDSPSGGYNNIDPNAPLAQTLWSLQVPLYITHASDGSKPPFIVSVPRFSYLAFLLPRLTAYFGLPCSSFHHEEVQLRNLAVGLLVDLYQPSLPWKLVVGDGPEWDIADTFTNSVKEADFVRNGNAKQIMSMSKENSTALWNAVLDNDYAAWSRIHRGLLNTPDPLKHVPIRIYVPSSSDRNDTSAGSFKVVQRLIPPRLPNLGMALKAVLPSLFPSSRDPVLANVILHGGPVPFRAPLEELMREAVYPDGWLCLQMRNNSNNFTDSFELYWTSTPEYDVRGWAQHMRARTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0SE49</accession>
    <name>G0SE49_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0062420</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006696494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SE49"/>
    <dbReference type="GeneID" id="18260280"/>
    <dbReference type="KEGG" id="cthr:CTHT_0062420"/>
    <dbReference type="eggNOG" id="ENOG502SMK2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009650_0_0_1"/>
    <dbReference type="OMA" id="SGHYYEF"/>
    <dbReference type="OrthoDB" id="3353407at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021822">
        <property type="entry name" value="DUF3405"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11885">
        <property type="entry name" value="DUF3405"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="652" mass="73527" checksum="7BE0B39BABF4AE72" modified="2011-10-19" version="1">MNIPKWLSFGHLNGFFTGLKALVSPREYRPEYPISSEERADFPFTVTYTGLPTPTPYNPFPAYDSVDYTLRYHEVEKCFLDKDGKVPVPSIYAYPGVVQGQPRHIIGSYEVLGFRDDVCFDRFGRFGPYGLGYTIEEGGFGAGLDTENEGSEVVWESTGKIDYSAVDWGDAQTRCHQANQHRFHDAIEHGEHLPSFSNEPSDLPRSPRPSSSQLTERETLPRTAIVIRAYTGYLWTAHAVLNVRAMISEAALSSGAEYSVHILLHVRDDHEPIWADPDTVQEILDRFVPPEFHDICTLWSEAQMRVIYPVRFGPSFRNPSGTDIHGELDMRWLGHYYELFDRLDRWSRQQTRIEMWERAAKYYIPAYHGSWVNFTRLVHNETINSGQVPIFGSVEFPGRIPTRSEALGNTFLPPSCEPSALQPDPDPVLSRCGVGEPADLITLNPLFDPDASGWVFEADVTGYPLDLPIPPRRTSIVTASRLSRRLLSVMHEETFRHGHAMFVEMFPASVALHHGLKAVYAPHPVYVDRAWDVASVDQAFNGGRGKTTSGPGSPFGLRNEHNHKGTTWYYHSEFAGLLWRRWLGYAQVDGRVWTTEVYEDGDDGGLGGSRNRGGGELRGGIGEESRPGSTGRMCLRSMLLHPIKWEHPNDPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0SE98</accession>
    <name>G0SE98_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0062990</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696606.1">
        <property type="nucleotide sequence ID" value="XM_006696543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SE98"/>
    <dbReference type="GeneID" id="18260337"/>
    <dbReference type="KEGG" id="cthr:CTHT_0062990"/>
    <dbReference type="eggNOG" id="ENOG502QR5D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076139_0_0_1"/>
    <dbReference type="OMA" id="ECQVKGW"/>
    <dbReference type="OrthoDB" id="5945798at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="256"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="155"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="191"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS18275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="310" mass="33711" checksum="A00855F27FA2988A" modified="2011-10-19" version="1">MPTPDFNSPTLFPPFLSLPLTTTTIPPPGTEGSQAALTNFSSLKPHKIEYPDPSLQQHDYYLMATVLQNMTITKPTLILTDSTGQRFALVYADRVAPGPFAGPRGGGTVGPNVLDLGRKGFKAGSTTVVLKNAKRNVVVREGWDDQIERMRTGMGVDLGLGKGNEFKEEDEEEVEKAVGEGDDAKKEKDGGQQSQSQNNGNQNGGTTKRKRKQGSIRISKAEEDEVKIIPGKLEDVQRVGKYLREREQDEAKGNSCAQCGAQGGEDKSLKQCTGCRGVKYCGKECQTKAWNEGGHKADCKIIKAIKAIWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEC7</accession>
    <name>G0SEC7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mediator of RNA polymerase II transcription subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0063280</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Mol. Cell" volume="81" first="1781" last="1788.e4">
            <title>Mediator structure and conformation change.</title>
            <authorList>
                <person name="Zhang H."/>
                <person name="Chen D.H."/>
                <person name="Mattoo R.U.H."/>
                <person name="Bushnell D.A."/>
                <person name="Wang Y."/>
                <person name="Yuan C."/>
                <person name="Wang L."/>
                <person name="Wang C."/>
                <person name="Davis R.E."/>
                <person name="Nie Y."/>
                <person name="Kornberg R.D."/>
            </authorList>
            <dbReference type="PubMed" id="33571424"/>
            <dbReference type="DOI" id="10.1016/j.molcel.2021.01.022"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (4.20 ANGSTROMS)</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Mediator complex subunit 1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EGS18304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PDB" id="6XP5">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.20 A"/>
        <property type="chains" value="a=1-736"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEC7"/>
    <dbReference type="EMDB" id="EMD-22284"/>
    <dbReference type="SMR" id="G0SEC7"/>
    <dbReference type="STRING" id="759272.G0SEC7"/>
    <dbReference type="GeneID" id="18260366"/>
    <dbReference type="KEGG" id="cthr:CTHT_0063280"/>
    <dbReference type="eggNOG" id="ENOG502RYK5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008378_1_0_1"/>
    <dbReference type="OMA" id="KWAEWIR"/>
    <dbReference type="OrthoDB" id="5310959at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019680">
        <property type="entry name" value="Mediator_Med1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041:SF4">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10744">
        <property type="entry name" value="Med1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
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    <keyword evidence="4 7" id="KW-0010">Activator</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med1" evidence="9">
        <location>
            <begin position="118"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="380"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="683"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="579"/>
            <end position="588"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU364059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10744"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="6XP5"/>
        </source>
    </evidence>
    <sequence length="736" mass="81523" checksum="F9EE649B1BA61FD4" modified="2011-10-19" version="1">MSTPIPTPGRNPLQGRTPSQAHGAAGTPPVSTPFSAAQAVFSPNGPRSSPQQFKRSPATVGSTTATGGRPPSAINFDSPSASAALGALQPMTPGMDMTIRSLANLGRASEDERAKRLEEVIHILSKSKGLVSEAGLERLARSLELEFMWESSMGSDNKRTLIVAGSALELLVEFSQDVVQSVTLNFPDSPEIVTKHAQKAGEILFNDLRLAPGQSPLTKSLARFAANFERLAVLDKLSINPGLNLYEAVADVYESLARLHAWELQKLREDPSLAGKDDEYLENLVLCTKSGKPAMNDRGRVGLALDYWKEKHLLRTPDAEVASWIADNERTWSILIGCAPLRDLSINPVRISDKWIGPNVVKTSLPDGLHTGEPIIDWLDPEPTFIPATDQQQQQQQQQQQQQQQQQQQQQADAPLLPPRLPEVAFHAVFDPPVHIPINLWQHLQEMGCVLPDETATQPFQQHHFRSFDSLVIPPPQGKETDATETRVFSCRKKTPFVPRRSGVRNGEGATQKMEYRIHQNTLFVPKPVMCRTLTEMSFSHPQQLVSILPYLRQYAFLAQLLENSFKPGPALQLPTDPNADTTTSKPTPNAKASHKKLDDFEAFLAKHSSHSGPISNMTPSQHQPSSDLSIDVTLRLVLPSPKLQIVFPLHATSKEEVKGKIAHVTFAVRENGRLEVEMQNMIEEEGDQMEGVKTEGDEDGEEKKRRRPQPGDLARALEVLEDVGKWAEFVRTRWV</sequence>
</entry>
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    <accession>G0SEF0</accession>
    <name>G0SEF0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NADH-ubiquinone oxidoreductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0063510</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
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        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="3 4 5" key="2">
        <citation type="journal article" date="2022" name="Sci. Adv." volume="8" first="eadc9952" last="eadc9952">
            <title>Conformational changes in mitochondrial complex I of the thermophilic eukaryote &lt;i&gt;Chaetomium thermophilum&lt;/i&gt;.</title>
            <authorList>
                <person name="Laube E."/>
                <person name="Meier-Credo J."/>
                <person name="Langer J.D."/>
                <person name="Kuhlbrandt W."/>
            </authorList>
            <dbReference type="PubMed" id="36427319"/>
            <dbReference type="DOI" id="10.1126/sciadv.adc9952"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.44 ANGSTROMS) OF 1-188</scope>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696658.1">
        <property type="nucleotide sequence ID" value="XM_006696595.1"/>
    </dbReference>
    <dbReference type="PDB" id="7ZM7">
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        <property type="resolution" value="2.77 A"/>
        <property type="chains" value="Z=1-188"/>
    </dbReference>
    <dbReference type="PDB" id="7ZMB">
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        <property type="resolution" value="2.75 A"/>
        <property type="chains" value="Z=1-188"/>
    </dbReference>
    <dbReference type="PDB" id="7ZMG">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.44 A"/>
        <property type="chains" value="Z=1-188"/>
    </dbReference>
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    <dbReference type="SMR" id="G0SEF0"/>
    <dbReference type="STRING" id="759272.G0SEF0"/>
    <dbReference type="GeneID" id="18260389"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22849">
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    </dbReference>
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        <property type="entry name" value="NADH_Ub_cplx-1_21kDa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37325">
        <property type="entry name" value="OXIDOREDUCTASE 21 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G05910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37325:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 21 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G05910)-RELATED"/>
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    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022976">
        <property type="entry name" value="NADH_Oxi_21kDa"/>
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    </dbReference>
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    <keyword evidence="3 4 5" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS18327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="3">
        <source>
            <dbReference type="PDB" id="7ZM7"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="7ZMB"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="7ZMG"/>
        </source>
    </evidence>
    <sequence length="189" mass="20329" checksum="238CE51ED751A4C6" modified="2011-10-19" version="1">MASKAAAAAASNAVSITKKYTVQSTGIWERIRRALVIDPNRSNGVPLNPYNRNPSPGDNPPLEYTDPVTIPAGDIADNPYWKRDFRRNYPRPSVIAQAQQVALLSVGSAAQPRVELIGEEGTKALVAAEEEGKEKGVAKYLEEKGAEEAKRVLALTGGLPPTPSGQTMVTGQWDVHKYGLAEEQSYGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEJ2</accession>
    <name>G0SEJ2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0063940</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEJ2"/>
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    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="TMEM234"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR28668:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 234"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS18369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="110" mass="12135" checksum="0461E62AE93A7FED" modified="2011-10-19" version="1">MSDTANPNPNPPHPPIINYILSFLLVGFAWGFTTPFMRAAARTYKPLPTPEDEASKGWVKRKLGQAWRAIVGLLKNPRYAVPLVVNLTGSVWFFLLIGKAGRIEPDGADC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0SET1</accession>
    <name>G0SET1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CTHT_0059600</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="14"/>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS17947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696278.1">
        <property type="nucleotide sequence ID" value="XM_006696215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SET1"/>
    <dbReference type="STRING" id="759272.G0SET1"/>
    <dbReference type="GeneID" id="18259998"/>
    <dbReference type="KEGG" id="cthr:CTHT_0059600"/>
    <dbReference type="eggNOG" id="KOG3359">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008438_0_0_1"/>
    <dbReference type="OMA" id="NCHLNAP"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23285">
        <property type="entry name" value="beta-trefoil_MIR_PMT4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000044">
        <property type="entry name" value="Dolichyl-phosphate-mannose-protein mannosyltransferase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF51">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="605"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="643"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="729"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="337"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="406"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="470"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGS17947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="784" mass="89510" checksum="D2D082D8DBB15888" modified="2011-10-19" version="1">MAGSPAPQGALRQRIVASTPKKTKESKDGAASDAELDKLVKEAAAAKAPAGSERDYKIAFAIITALAFLTRFWGISHPDQVVFDEVHFGKFASYYLQRTYFFDVHPPLGKLLFAFMGWLVGYDGHFHFDNIGDPYVINKVPYVAFRALPAILGSLTVSVVFLIMWESGYSLPACILASGLVLLDNAHIGQTRLILLDATLVFAMACSLLCYIKFYKLRHEPFSRKWWKWLILTGFALSCDISTKYVGLFAFITIGSAVCIDLWDLLNINRPKGALTLPQFGKHFAARAFGLIFMPFMFYLFWFQVHFSILTRSGPGDDFMTPEFQETLSDNIMLANAVTIDYWDTITIKHKETKAYLHSHPDRYPLRYDDGRVSSQGQQVTGYPFNDTNNWWQILPAGPFEEPKLGRHVKHRDLVRLRHVGTDTYLLSHDVASPYYPTNQEFTTVSFNEAYGDRAADTLFEVRIEHGKPGQEFKSISSHFKLIHNPSKVAMWTHPTPLPDWGHRQQEINGNKQIAPSSNVWLVEDIVSLPADHKRREKPERKVKTLPFLRKWFELQRSMFWHNNQLTASHPYASLPYQWPFLLRGVSFWTNSETRQQIYFLGNPVGWWIASSVLAIYVGIVLADQFSLRRGIDALDHRTRSRLYNSTGFFFLAWATHYFPFFVMGRQLFLHHYLPAHLASTLVTGALVEFIFSPEAPEHEIAAQQAKSSSSGKRGGVAMKRHITARERFAGQSLMGSWIATAVILALVAWSWWFFLPLTYGYPGMSVQQVLRRKWLGYDLHFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEU3</accession>
    <name>G0SEU3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative WD repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0059720</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS17959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696290.1">
        <property type="nucleotide sequence ID" value="XM_006696227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEU3"/>
    <dbReference type="STRING" id="759272.G0SEU3"/>
    <dbReference type="GeneID" id="18260010"/>
    <dbReference type="KEGG" id="cthr:CTHT_0059720"/>
    <dbReference type="eggNOG" id="ENOG502QPI7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010671_2_1_1"/>
    <dbReference type="OMA" id="LATETWL"/>
    <dbReference type="OrthoDB" id="20669at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991:SF12">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G05640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G05640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="534"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="724" mass="80414" checksum="C41A38C7C4577BD9" modified="2011-10-19" version="1">MSSFSNYPMTANYYGQESAGTSSSAIYLPPDTQSGEEYDGNEANIYSSESYMDMGDSNAYGNNHYGYSGDDEIDAQSGAEQDDYLNTDQSRVDENSVQQPSRDPPEGEDVDADDDDGDPGGVALDDIGLPLVSHVGPGEYTSGEEDDYDEQDDLAGMNDTDSTFYINPNIMSFALLPDNLDAPVPMPPNDVGNVPSAVPNPPAFTGALYTAPFHLPPAMPPQMSPLTVGSLNLGLWEFLYNWSLANANYKARSSLSPRLDKVQELAKNEGTPQRVDYADLQGDKCDFQGINWVELGIDRTWARERRLNTYKNYVNVPGSDRWNPGLPDLLLPRADSFFRFRRMYIRQNVHLAHFQLRNLLAATSRARVFYPILGAVQQFNPLSNTTRNIMRLNEAPPAQISAMDAAYGVLVAGGFNGEYVLRHLDTDEPESTACHEGIITTSVSGITNHIAIQLGRSSSPSNPRAAFASNDTCFRILDLATETWLQTEKFDYAINCTALSPDRRLRVLVGDERDVLITADEPRSDGTPNILYKLPAHRDFGFACDWADDGWTIATGFQDKTVQIWDARRLVDSRGSPQPVCVLRSEMVGVRSLKFSPVGSGPRVLVAAEEADFINIIDARSWRSKQIFDVFGELAGTVWVDGGQGLYVLCADRHRGGIIYLERCYGSVRGLEQNGVPEDGMVWETEESAEGDWRRNIFTEEKRSRHRAWRGRRRPVGHVDMGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEX8</accession>
    <name>G0SEX8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0060070</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS17994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696325.1">
        <property type="nucleotide sequence ID" value="XM_006696262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEX8"/>
    <dbReference type="STRING" id="759272.G0SEX8"/>
    <dbReference type="GeneID" id="18260045"/>
    <dbReference type="KEGG" id="cthr:CTHT_0060070"/>
    <dbReference type="eggNOG" id="KOG1667">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040079_1_1_1"/>
    <dbReference type="OMA" id="KGYTCCK"/>
    <dbReference type="OrthoDB" id="1898560at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06466">
        <property type="entry name" value="p23_CS_SGT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1130.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007051">
        <property type="entry name" value="CHORD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039790">
        <property type="entry name" value="CHRD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46983:SF3">
        <property type="entry name" value="CHPADIPLOID STATE MAINTENANCE PROTEIN CHPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46983">
        <property type="entry name" value="CYSTEINE AND HISTIDINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04968">
        <property type="entry name" value="CHORD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51401">
        <property type="entry name" value="CHORD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CHORD" evidence="6">
        <location>
            <begin position="9"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="CHORD" evidence="6">
        <location>
            <begin position="147"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="5">
        <location>
            <begin position="230"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="73"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS17994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="339" mass="37369" checksum="ED3D8FB790AC31B7" modified="2011-10-19" version="1">MAQAEAQKCVHQGCGKLFTDPDEVCRYHPGPPIFHEGQKVRQANHGVSASRPAGWKCCKPRVLTFEEFMAIPPCTEGKHSTTDVPPPIEKREADPAAVAAATAASELPPPPKRAPISQPQHIPTPPPPPPESEDDDPSIEIPDGQVCRRRGCGAVYKKGSSREDEKCVHHPGAPIFHEGSKGYTCCKRRVLEFDQFMKIEGCKTKNRHLFVGSGNKDKNKNTNADGEEVLDTVRTDFYQTQTSVIASFFLKKIDKDKAKVEFQDRAVDLDLRTTDTPVKRYKKLVQLWGAIDPAKSTFKVLGTKLEVSLAKADGASWPVLRAEDRPTGEILQVGRAGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFT9</accession>
    <name>G0SFT9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0072110</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697472.1">
        <property type="nucleotide sequence ID" value="XM_006697409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFT9"/>
    <dbReference type="STRING" id="759272.G0SFT9"/>
    <dbReference type="GeneID" id="18261249"/>
    <dbReference type="KEGG" id="cthr:CTHT_0072110"/>
    <dbReference type="eggNOG" id="ENOG502QWSP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013431_1_0_1"/>
    <dbReference type="OMA" id="GFKKWVT"/>
    <dbReference type="OrthoDB" id="244495at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF118">
        <property type="entry name" value="CYCLIN, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="733"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="733"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="762" mass="82178" checksum="152049FABF06AB1C" modified="2011-10-19" version="1">MFSDSRGQSFTNPGLALPSPAGSFICHSSLDAIKTSQPQKPPQRSLPVGLSTPPAETDNAMGTTYEVRHLATCENYPLCHSSIYASSLASSDACRSALSERVANEQSCTPHHRYAAFPSAQPQDYATSQPSMVSASRVSTHKLTTASSIEQDVGSHNQQFDPRCLSRASPSPLIRSESDDMEPNSEDSSLTIHSMAVPGCISPNGGNLADFMAEMTALFWFVSDNKLAKLEKTLPLSPGARIEPLTSTAAADHFKTWVTSVLSTTQVTLNVAILALLYIRRLKQMNPTVKGRPGSEYRLLTVALMLGNKFLDDNTYTNKTWADVSGIPVKEIHVMEVEFLSNMRYRMLVSAEEWEDWINKLSDYWSYLQASRRQWSPSPSPLRIPSPTLLSFSSPLPSPTAPSQSTSSLSAGTSFQSSSSSLSPTDSWNDSPFFTVPPSSPLALKPQTSRSLKRPCSHEDLVEPPTKRTNRVRETSMPRPTHSQPVPQCAAVTSTSSQPLTNGLPSCLPSGLPVTSRSASVASSDQSRLSVPSLTLNTNQAPVTHGQTYPPTTYVPQQSSPLSLPPLVPSVRAMSTVYPATTCSSSQAMAATCGPVTTPTTTFPPVSYSTPTKRLSPQHPATTVVFGNSSPIVDGTNPPMSTPNANGAHTPVSHSPSYYLRQRNSPYGPVRHVNTLLYPPPSAFLQQYHLPASVLPNQMHYRPLGKRAEYRTGIVPEFTSGAVVLSNSSHLATTQATNPSSRATVSAPTSYAPRSATRLAPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G0SG12</accession>
    <name>G0SG12_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0064650</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696769.1">
        <property type="nucleotide sequence ID" value="XM_006696706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SG12"/>
    <dbReference type="GeneID" id="18260503"/>
    <dbReference type="KEGG" id="cthr:CTHT_0064650"/>
    <dbReference type="eggNOG" id="ENOG502T9UA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069188_1_0_1"/>
    <dbReference type="OMA" id="RIHNRNT"/>
    <dbReference type="OrthoDB" id="5207784at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="280" mass="32290" checksum="9AAE73E767039915" modified="2011-10-19" version="1">MDKSTPPPSLPHLSAPPPDYDPAPPSLPDPDEILPPAILTLHGRFIYPVQPCGTPSSNPLYQLSRAIHAQGRATESIDFQRLDYRVHNSDGLVGPSVTHRARDVYTLLHRPPMFDYVPLDARIAPPTTNLKRNMGQLKVLVSLWAPYLPGKKKFRVVRVPPEDDQAIWRLRGDKEKLKEKNWETVFQLSREHDKEWCWHDSEGRLLARQMEQVRKAGETEETEQEHQLRILVPLPRKEMDALVALWCLWMWHLHVEATPVKKTLDDVRRIMAAAPGVWRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGI9</accession>
    <name>G0SGI9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">alcohol O-acetyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.84</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Alcohol O-acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0066490</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Displays enzymatic activity both for medium-chain fatty acid (MCFA) ethyl ester synthesis and hydrolysis (esterase activity). MCFA are toxic for yeast and this enzyme could thus be involved in their detoxification by esterification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aliphatic alcohol + acetyl-CoA = an acetyl ester + CoA</text>
            <dbReference type="Rhea" id="RHEA:17229"/>
            <dbReference type="ChEBI" id="CHEBI:2571"/>
            <dbReference type="ChEBI" id="CHEBI:47622"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.84" evidence="6"/>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696946.1">
        <property type="nucleotide sequence ID" value="XM_006696883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGI9"/>
    <dbReference type="STRING" id="759272.G0SGI9"/>
    <dbReference type="GeneID" id="18260687"/>
    <dbReference type="KEGG" id="cthr:CTHT_0066490"/>
    <dbReference type="eggNOG" id="KOG1838">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032487_1_0_1"/>
    <dbReference type="OMA" id="MMTTSWG"/>
    <dbReference type="OrthoDB" id="5954035at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008126">
        <property type="term" value="F:acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004026">
        <property type="term" value="F:alcohol O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051792">
        <property type="term" value="P:medium-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000137">
        <property type="entry name" value="EEB1p Acyl-coenzymeA:ethanol O-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012020">
        <property type="entry name" value="ABHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF63">
        <property type="entry name" value="ALPHA_BETA HYDROLASE 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005211">
        <property type="entry name" value="Ab_hydro_YheT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="9">
        <location>
            <begin position="122"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00066969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00080774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005211-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS17328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="422" mass="47540" checksum="B3B0F37D329691B5" modified="2011-10-19" version="1">MEWLGRARIAFTHCPSPLPLKRKDGSFTDLRRICEDSVPPCQLNPLLFNGHVQTMWTSVKDPGPTIYYRRKIFNAEHTTYKGTFAVDFAVPPHDEVDDTLPPRTAYFSEEEWAKIGSDDSRPMLIVLHGLSGGSHEVYLRHAIAPLILNGGGWEVAVVNSRGCANSRITSGILYNARATWDVRQVVNWARKTFPNRPLFALGFSLGANILTNYVGEEGANCSLKGAIVVGNPFDLELANKALQRTQLGRLYSRIMGSNMKRLMDLHKDEIIKYTNLNFDRIQNITYLHEFDREVQTVTWGYPTENAYYRDASSSDAVLGIRIPFLALSALDDPIAVCEAIPYQEFQQNPYTVLCTTSLGGHLSWFEVGGGRWHAKPICNFLNRMVKEIDLDSIKPDVTGIFEPSEFAGEFHPVRRKLEVSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGN9</accession>
    <name>G0SGN9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0067030</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696996.1">
        <property type="nucleotide sequence ID" value="XM_006696933.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0SGN9"/>
    <dbReference type="GeneID" id="18260741"/>
    <dbReference type="KEGG" id="cthr:CTHT_0067030"/>
    <dbReference type="eggNOG" id="KOG1932">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002317_2_1_1"/>
    <dbReference type="OMA" id="TDLFMKK"/>
    <dbReference type="OrthoDB" id="308861at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09839">
        <property type="entry name" value="M1_like_TAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057345">
        <property type="entry name" value="Ig-like_TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037813">
        <property type="entry name" value="TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057991">
        <property type="entry name" value="TPR_TAF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25316">
        <property type="entry name" value="TAF2_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25577">
        <property type="entry name" value="TPR_TAF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 2 Ig-like" evidence="8">
        <location>
            <begin position="551"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 2 TPR repeats" evidence="9">
        <location>
            <begin position="740"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1182"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1270"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1405"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1215"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1276"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1293"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1310"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1434"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1527"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1545"/>
            <end position="1557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS17378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1589" mass="175814" checksum="497B2FDD7D981C09" modified="2011-10-19" version="1">MPAPIENEINEPAALEWPQGAEPFVVIKQEVELDVDLAKKQISGVSTLWIFPLLPDMEEISLDARNCEIDLGNVTVDGVKTQATFSDPYDLMQTPSQWQIGATQHHILKKRMASLRPIKRPEVPNLDRVSQPCSVPCDGALKISLRPEGMNKDEPRRILKIKTLKVGQDSLLDAPDPNDKNGLKISIPFRSKHIRDGIHFVGCDEGDQRYPHVYTRHSLEPGTACCIFPCVDDPASRHPWKISIKCPRTLGDAFPRSGENTIYLADEERLLDLTVICSGNLIGEQIDPIDNHKKIMTFESQLTAAQHIAFAIGPFEHIDLWSEFRTEEADEKLGVNAAKIHAYCLPRRADEVRHTCAPIVRAADFFAPEFGRYPYDSYKICFVDDMVSDTVTATSMSLCSNRLLYTEDLMTPRSSWLVVGIQWFMTDLFMRSLCGNNWYRFHIKTLSDRLVEVDVHRPSLHDLGEYLHVGDFELEFMSLKAPLVLFILDQRMSKIPGSSGIVRVISQLVSNANINTTIETTSLSEADFRKACEKKSQYRPDELWEQWVHGAGCPKLSVKQRFNKKNLNVDITITQVQAKDSSQPKAITKDVFQRELFEEVHEVWAGPVPKYFTGPITIRVHEADGTPYEHYLSISDKDKGHTQLQIAYNTKYKRMKRTKKAIMAAAAASTGDKHDIQEDDIVYFNMLGDVLMSPQDAIDWGLQDWSESVQQQMDQESYEWIRFDCNFEWLCALHSDMPGYMYSAQLQQDRDVVAHQDAMLFFSKQRHHAVTSTIDVRTVMDRRYFYGIRVMAAHDLTKQANPDLNCIGKAHLILLYRHFFCDKVIGKNGQVTYPPAPNDFYDKAQYEVQCAIPQAIARIRENGFCPRDARRFLLDLLVLNAETEGEYSDHFYICKLLQALTTSIIPEKYTGETDLLSSLRSDDPVESELKDFIKAVLDEIEKYRRKDEWELTWHNIWTTTTLDCKMRLMKARVIPVEPIEFVRYLQDENLDLIRIKAHECLVELGLLARPCILRLFLADMTSCPSPFVRDRLFKIFCRGLAAIALGESSISQPRQEDVVKHDDGDLILEAGESEIRQRKLDATRNQSIQQTIAALKDELKDNMELQDAMWKAIESPWLSAREKHQLLTVCSAMWEPDDSLLMTFNYPKIWKCTREVVVNGKAGVNRKSCIVRFTTHYRTEPRNKRPFDFISSGSVAGQPSAADNKPPEPKRIRISRPSISLPSGSVPPTPSTAQRKDSISVSIIRPAPPPTPTAGTPADSIAVQPLQRVSSAPLAASPPPMSSGPSLPPKQTVKLSVSGAGSISSEQKTPKASSSSTSTSKKRKSDDADAPSTTGSTFQSRSTKKARTASASVALENGAGTITANGGGGPARPRRVVTVPFKAWHRLPERIYGAIAAERRALSLGSGVKPPLSRSNTESGSGTGAPSRRITLPTSKPSSSSTAGTGAQRAASGEGSSSSYAAGRTALPSSAPGGSSSSLAGSSGSTQGAASQSQNAGAGNNGNGITVKKARKPLPTAAPKDRDHSLHGNTPQQQHGHGSSRQEPLSSAGAGTTNAGLGSSGSGTGGLQQQKKVIKLKLKVPGPSGTGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGT6</accession>
    <name>G0SGT6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL15</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">L29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0067510</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="476" last="476">
            <title>High-resolution structures of a thermophilic eukaryotic 80S ribosome reveal atomistic details of translocation.</title>
            <authorList>
                <person name="Kisonaite M."/>
                <person name="Wild K."/>
                <person name="Lapouge K."/>
                <person name="Ruppert T."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="35079002"/>
            <dbReference type="DOI" id="10.1038/s41467-022-27967-9"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.90 ANGSTROMS) OF 20-164</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e57984" last="e57984">
            <title>Structural insights into coordinating 5S RNP rotation with ITS2 pre-RNA processing during ribosome formation.</title>
            <authorList>
                <person name="Thoms M."/>
                <person name="Lau B."/>
                <person name="Cheng J."/>
                <person name="Fromm L."/>
                <person name="Denk T."/>
                <person name="Kellner N."/>
                <person name="Flemming D."/>
                <person name="Fischer P."/>
                <person name="Falquet L."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="37921038"/>
            <dbReference type="DOI" id="10.15252/embr.202357984"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.91 ANGSTROMS) OF 23-164</scope>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2024" name="Nat. Commun." volume="15" first="716" last="716">
            <title>Methionine aminopeptidase 2 and its autoproteolysis product have different binding sites on the ribosome.</title>
            <authorList>
                <person name="Klein M.A."/>
                <person name="Wild K."/>
                <person name="Kisonaite M."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="38267453"/>
            <dbReference type="DOI" id="10.1038/s41467-024-44862-7"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.10 ANGSTROMS) OF 23-164</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697043.1">
        <property type="nucleotide sequence ID" value="XM_006696980.1"/>
    </dbReference>
    <dbReference type="PDB" id="7OLC">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="La=20-164"/>
    </dbReference>
    <dbReference type="PDB" id="8OO0">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="La=23-164"/>
    </dbReference>
    <dbReference type="PDB" id="8PV8">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.91 A"/>
        <property type="chains" value="La=23-164"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGT6"/>
    <dbReference type="SMR" id="G0SGT6"/>
    <dbReference type="STRING" id="759272.G0SGT6"/>
    <dbReference type="GeneID" id="18260789"/>
    <dbReference type="KEGG" id="cthr:CTHT_0067510"/>
    <dbReference type="eggNOG" id="KOG1742">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109163_1_0_1"/>
    <dbReference type="OMA" id="WGRVGQH"/>
    <dbReference type="OrthoDB" id="61900at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L27a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_uL15_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="11 12 13" id="KW-0002">3D-structure</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="8">
        <location>
            <begin position="88"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00080124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS17425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="7OLC"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="8OO0"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="8PV8"/>
        </source>
    </evidence>
    <sequence length="164" mass="18808" checksum="B4C4E905B4E68F92" modified="2011-10-19" version="1">MVRQLTSGRFEREMLTFAAYPVFQDKKAPRPRVRRRVGKHRKHPGGRGMAGGQHHHRTNLDKYHPGYFGKVGMRHFHLLRNHYWRPSINIDKLWSLVPSDVREQYLSGQKKDTAPVIDLLSHGYAKLLGKGRLPEIPVVVRARYVSAEAERKVKEAGGVVELVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G0SH42</accession>
    <name>G0SH42_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0068620</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697149.1">
        <property type="nucleotide sequence ID" value="XM_006697086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SH42"/>
    <dbReference type="GeneID" id="18260900"/>
    <dbReference type="KEGG" id="cthr:CTHT_0068620"/>
    <dbReference type="HOGENOM" id="CLU_125059_1_0_1"/>
    <dbReference type="OMA" id="METPQLA"/>
    <dbReference type="OrthoDB" id="5399555at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="158" mass="17264" checksum="74204F1D4BF83C98" modified="2011-10-19" version="1">MAPSVRPPTPTSDSTVPSKNLNLALQMPNSSSADPEPHTSSSPSPPTLTNESPSSASQNRASVRLSTYSMTPSLAPSVGSLDPEIRPIVDGLERLKNPPLEDKQRVFLNEEKRENLARLALNAKLERALSRRMTSQDAVMRPRKPSVVEVVNEKKEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0SH84</accession>
    <name>G0SH84_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Benzoate 4-monooxygenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0069080</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697191.1">
        <property type="nucleotide sequence ID" value="XM_006697128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SH84"/>
    <dbReference type="SMR" id="G0SH84"/>
    <dbReference type="STRING" id="759272.G0SH84"/>
    <dbReference type="GeneID" id="18260946"/>
    <dbReference type="KEGG" id="cthr:CTHT_0069080"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_993978_0_0_1"/>
    <dbReference type="OMA" id="CGTRIIT"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF29">
        <property type="entry name" value="BENZOATE-PARA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS17573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="280" mass="30640" checksum="9DC6616C9067F70C" modified="2011-10-19" version="1">MIARSSNPDGAAHLDILNWFNYLAFDVIGDLAFGAPFGMLSSGADMAEVRASPESQPIYAPAIEILNRRGEVSATLGIMPWLRPLAKYFPDPFFSKGLEAVDNLAGIAVARVKARLENPPPTHRKDLLQRLMEGRDEKGNPLGREELTAEALTQLIAGSDTTSNSSCALLYYVVRTPGVLKKLQEELDAKLPADIDVPTFEMVRDLPYLSAVVNETLRFHSTSGIGLPRQIPPMPKKACGTRIITSLQGQFSAFLLIRSIIRRRFGARMRMSSIRSGGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHF4</accession>
    <name>G0SHF4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA ligase</fullName>
            <ecNumber evidence="12">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CTHT_0069830</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="12"/>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697261.1">
        <property type="nucleotide sequence ID" value="XM_006697198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHF4"/>
    <dbReference type="STRING" id="759272.G0SHF4"/>
    <dbReference type="GeneID" id="18261021"/>
    <dbReference type="KEGG" id="cthr:CTHT_0069830"/>
    <dbReference type="eggNOG" id="KOG0967">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005138_4_2_1"/>
    <dbReference type="OMA" id="WIKYKRD"/>
    <dbReference type="OrthoDB" id="206088at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903461">
        <property type="term" value="P:Okazaki fragment processing involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07900">
        <property type="entry name" value="Adenylation_DNA_ligase_I_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07969">
        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3260.10:FF:000004">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000062">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000016">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF4">
        <property type="entry name" value="DNA LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 12 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="15">
        <location>
            <begin position="588"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="827"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGS17643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="863" mass="96314" checksum="7C80D0D35D0FE3AC" modified="2011-10-19" version="1">MAPKQATLGQFFGQANGTKSKPAPMQQTKLSFATKAKTEEKNDKAKREDDVEDVQPEEDAGGKSPEPKKKRGRPAKSAVAQKDANGVEDEEGESAAPVTKRPRKGRRVVKDDEEDEIMEDVLSESDAKQEAKKPPVSAPEPALIKKSEVEERTPESESEVEEAEEELQDEEEKPDVAAKVRQKIQATLKSNVKHPYPDWKEGEPVPYAALCQTFSLIELTSKRLEIMAHCSLFLRQVMRLTPDDLLPTVLLMVNKLAPDYAGIELGIGESLIMKAIGETTGRSLSVIKQDQKEIGDLGLVAVKSRATQPTMFKPKPLTVRGVHKILMDIATVTGNGAQQKKVDFIKKLLSASDVNMKGKADITKDKGGPSEAKFLVRFLEGKLRLGLAEKTVIVSLAQAMVAHEAWKKGKVPSTADLEKGEQILKQVYSELPSYDVIIPAMVKHGIFNLREHCKLRPGVPLKPMLAKPTKAITEVLDRFEGQTFTCEYKYDGERAQIHYVAKDTGEALSQSASGASKEVGKGVAAIFSRNSEDLSKKYPDVLAKLPTWVKEDTKSFVLDCESVAWDVNEKKVLPFQTLMTRKKKDVKVEDVKVKVCVFAFDLLYLNGEAIVHKSLRERRELMYKAFQPVEGEFAFATHMNSQELEDIQAFLDESVKASCEGLMVKMLDGEESGYEPSKRSRNWLKIKKDYLSGVGDSLDLVVLGAYYGKGKRTSVYGAFLLACYNPIKETYETVCNIGTGFSDSVLEELYKQLSEIVIDRPKPFYSHSSTAQHQPDVWFEPRYVWEVKTADLTLSPRYKAGMYEGVDPSGEKGISLRFPRFIKVRDDKKPDEATSSRQVAEMYRKQESVAKSKGPAVDDDWEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHN5</accession>
    <name>G0SHN5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0070670</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697342.1">
        <property type="nucleotide sequence ID" value="XM_006697279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHN5"/>
    <dbReference type="STRING" id="759272.G0SHN5"/>
    <dbReference type="GeneID" id="18261105"/>
    <dbReference type="KEGG" id="cthr:CTHT_0070670"/>
    <dbReference type="eggNOG" id="KOG0581">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_401133_0_0_1"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000165">
        <property type="term" value="P:MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000263">
        <property type="entry name" value="MAP kinase skh1/pek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF5">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINAE MKK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="198"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="577"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="581"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="592"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS17724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="686" mass="74721" checksum="A9E57BCCDE71908B" modified="2011-10-19" version="1">MSAIPQQPQAQPAPAPSTIPPAPIIRPPPLSGRAGNRPPRLGLSIPARGTNAPPPKPPLPTLHLATPMGSTVTPQEQPVRSLSQQSVSGSESSTAHSRSGSFGPLDGRASNPTSAGSQFSVMSFASQFGLGSTRQPSDPVSAVGSLYSNASEGVDIDRDASLHGLESFSQLSIEKARILDVEDLDDEGWRIVALEKRIIELGRLGEGAGGSVTKCKLKGGETIFALKVGCSYWCIAFEDRLLTAQVITTNPDPSVKRQIVRELGFNKECASQHICRYYGAFVDPATATISIAMEFCEGGSLDSIYKEVKRLGGRTGEKVLGKIGEAMLRGLTYLHSKKIIHRDIKPSNVLLTRAGEVKLCDFGVSGEFGTKGDANTFIGTSYYMAPERITGQSYTITSDVWSTGVTLLEVAQHRFPFPADGTEMQPRAGLIDLLTYIVKQPPPKLKDEPDITWSDNFKYFIECWQLQQLQQQHQEQKAQHEQEQKQTGLRFSGSLAGKLTSTWRRVSARLKPWLPSQPSTMCGLRRRTWPLCDTDEEMGRLAAVEELVMEMGRVVGAVEKGELVGMMEEVVRVVEKRNGEVQEEGEETEKEDEGKGDKRGMEQQNRARAWAGQFRPASRGKVSSQQQQKAITITIQEAAKLINSNNNERGEGRFATTSAAKDIEGGLGKGKEVIAGRGDVCREGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHU4</accession>
    <name>G0SHU4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="6">1.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0073400</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="6"/>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697596.1">
        <property type="nucleotide sequence ID" value="XM_006697533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHU4"/>
    <dbReference type="STRING" id="759272.G0SHU4"/>
    <dbReference type="GeneID" id="18261378"/>
    <dbReference type="KEGG" id="cthr:CTHT_0073400"/>
    <dbReference type="eggNOG" id="KOG1231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017779_3_1_1"/>
    <dbReference type="OMA" id="GQGFEWA"/>
    <dbReference type="OrthoDB" id="7786253at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000014">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF116">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE (CYTOCHROME) (AFU_ORTHOLOGUE AFUA_7G02560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="9">
        <location>
            <begin position="179"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS17014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="611" mass="66565" checksum="179B5A801CE71F60" modified="2011-10-19" version="1">MARLAAVGGALPRGLAAQRSLRLGSSAFARASAGVVRFNSNETTPHPPPPPPRRPGASFQGQLTQSISQRLERERADLERLARVRKESPVARNFTLTFVLFFVGSVSWWLGYKYPRDVDPNSTLPLSATKPPVHKTAPVNLEAAWADFVEIVGQENVSTVDTVLQQHATSEWSTHQADPAHKPFCVVFPATTEEVSKVMKVCHTRRIPVVGYSGGTSLEGHYTPTRGGICIDFSRMNKLVALHKEDLDVVVQPGIGWEQLNEELAPHGLFFPPDPGPGACIGGMIGTGCSGTNAYRYGTMKDWVLSLTVVLADGTVIKTRQRPRKSSAGYDLTRLFVGSEGTLGLVTEATLKLAVRPAATSVAVASFPSVRAAADCVARVVADGIPVAAVELLDDDQMKFINATGSTTRKWREAPTIFFKFAGTPTSVKEQVEMVSKLAKHAKAQSFDFARDANEQEELWSARKDALWATMAQRKPGDHVWTGDVAVPMSRLPEIVEATKKDLRASGLTSSIVGHVGDGNFHVILLYGDKERKIAEECVHRMVRRAVEMEGTVTGEHGVGLVKRDYLPHELGEATVDTMRKIKSALDPLCLLNADKVIRIQKPARGEVTDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G0SI15</accession>
    <name>G0SI15_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0074140</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EGS17085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006697604.1"/>
    </dbReference>
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    <dbReference type="STRING" id="759272.G0SI15"/>
    <dbReference type="GeneID" id="18261452"/>
    <dbReference type="KEGG" id="cthr:CTHT_0074140"/>
    <dbReference type="eggNOG" id="KOG0498">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006113_0_0_1"/>
    <dbReference type="OMA" id="RMKSVWD"/>
    <dbReference type="OrthoDB" id="421226at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005221">
        <property type="term" value="F:intracellularly cyclic nucleotide-activated monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000057">
        <property type="entry name" value="Cyclic nucleotide-binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CNG_cation_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
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        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638:SF24">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G03170)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="cNMPbd_u2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="77"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="292"/>
            <end position="427"/>
        </location>
    </feature>
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        <location>
            <begin position="556"/>
            <end position="603"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
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        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="704"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="437"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="704"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="725"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
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            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGS17085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="737" mass="81035" checksum="799430222A3E3DE3" modified="2011-10-19" version="1">MRRTRSPHSSSAYRSIIHHGTSSSSSQQSTPNPSALLRSFESDTNPARPIRPSPLTTASPIPDMPLDLLERIRSFPLFSSAPEEFLVAVGSHLRPQIHAGHDHILTEGEEARAMYWLVRGVVAVTSRDGEAVYAELKPGAFFGEIGVLMDVPRTATIIARTKCLLVVLMKEDLMAELPRFPEMEKAIRQEALERLAILKKKKRLSEGAEAVLKVGEQQQQQQQQQQQERKKHEGVPGEVVTGDVGVIKGGAVVNTKKRKSPSPGVIEDPAVSGSALGSAYVNVRKTLKELPLFATLPADILHFLGLSAQPKSYPPFTDIVRQGTRGSEIYFIVHGEAEVVKEPEEPLSPTMVKKNGSGPATSYTRPRLRQGQYFGEVASLGLSEERTATVRAITTVECLVIGGEALEELWRRCPPEIRAQVEETARKRFHKARQEAEREDVEMSDVGDENVGPTEGPVIITPVVTQMLAADEETRSPTDPDPYLSVDMENLRARRRSSIAPPPAQTADSSGIVVGGAIKIPPVQPAPPLLSPVSLDEPPFPFKRARLGRDSAKEYSLSKQGLPDNVLVAVFKHLDLLSMLKIRAVCRRWRTLLTTSADLCTHVDLSPYNRRVTDHAIIHILAPFIGARPVEININDCFHITDEGFHCLWKTCGRNVKVWRMRSVWDVSAAQIHNMAEYAKGLEEIDWSSCRKVGDNLLARVAAPPSATSTSPTASTSPTGRWPTSLCTPLNAWNPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G0RXT1</accession>
    <name>G0RXT1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0000280</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RXT1"/>
    <dbReference type="GeneID" id="18254066"/>
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    <dbReference type="eggNOG" id="ENOG502SFDS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119195_0_0_1"/>
    <dbReference type="OMA" id="HVCLTHE"/>
    <dbReference type="OrthoDB" id="3649348at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS24097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="147" mass="15537" checksum="B37B58D42DCFCA20" modified="2011-10-19" version="1">MASTSIPVASLGANPEVAKQIKELLLPEYDLVHMCLSLESASTEFTEILSGNLEVAPSSGIGSNVDKPTTERRVPRAIVLGGGVSDEDYVALKEALVKGGLKVEGDGEDVVKFVRVLRDDILALGASRPDPTVISQVIRKKLGQLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0RXU4</accession>
    <name>G0RXU4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH dehydrogenase (Ubiquinone)-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0000410</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="4 5 6" key="2">
        <citation type="journal article" date="2022" name="Sci. Adv." volume="8" first="eadc9952" last="eadc9952">
            <title>Conformational changes in mitochondrial complex I of the thermophilic eukaryote &lt;i&gt;Chaetomium thermophilum&lt;/i&gt;.</title>
            <authorList>
                <person name="Laube E."/>
                <person name="Meier-Credo J."/>
                <person name="Langer J.D."/>
                <person name="Kuhlbrandt W."/>
            </authorList>
            <dbReference type="PubMed" id="36427319"/>
            <dbReference type="DOI" id="10.1126/sciadv.adc9952"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.44 ANGSTROMS) OF 1-209</scope>
    </reference>
    <dbReference type="EMBL" id="GL988030">
        <property type="protein sequence ID" value="EGS24110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690596.1">
        <property type="nucleotide sequence ID" value="XM_006690533.1"/>
    </dbReference>
    <dbReference type="PDB" id="7ZM7">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.77 A"/>
        <property type="chains" value="a=1-209"/>
    </dbReference>
    <dbReference type="PDB" id="7ZM8">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.76 A"/>
        <property type="chains" value="a=1-821"/>
    </dbReference>
    <dbReference type="PDB" id="7ZMB">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.75 A"/>
        <property type="chains" value="a=1-209"/>
    </dbReference>
    <dbReference type="PDB" id="7ZME">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.83 A"/>
        <property type="chains" value="a=1-821"/>
    </dbReference>
    <dbReference type="PDB" id="7ZMG">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.44 A"/>
        <property type="chains" value="a=1-209"/>
    </dbReference>
    <dbReference type="PDB" id="7ZMH">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.47 A"/>
        <property type="chains" value="a=1-821"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RXU4"/>
    <dbReference type="EMDB" id="EMD-14791"/>
    <dbReference type="EMDB" id="EMD-14792"/>
    <dbReference type="EMDB" id="EMD-14794"/>
    <dbReference type="EMDB" id="EMD-14796"/>
    <dbReference type="EMDB" id="EMD-14797"/>
    <dbReference type="EMDB" id="EMD-14798"/>
    <dbReference type="SMR" id="G0RXU4"/>
    <dbReference type="STRING" id="759272.G0RXU4"/>
    <dbReference type="GeneID" id="18254079"/>
    <dbReference type="KEGG" id="cthr:CTHT_0000410"/>
    <dbReference type="eggNOG" id="ENOG502SNQW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018143_0_0_1"/>
    <dbReference type="OrthoDB" id="2014058at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008699">
        <property type="entry name" value="NDUFB8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12840:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12840">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE ASHI SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05821">
        <property type="entry name" value="NDUF_B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4 5 6" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="710"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="760"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="723"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="760"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="812"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS24110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="7ZM7"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="7ZM8"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="7ZMB"/>
        </source>
    </evidence>
    <sequence length="821" mass="89756" checksum="3034A04CB65A341B" modified="2011-10-19" version="1">MLSRRLVRAVAPLRSPVLPAARRLPLIQQRTFLPEAMVGRSKIDEKYPDSDYPTLTDKEDPDMNGGYINPPRIKRQFRDPHADWWDKQERRNFGEPVHEDHDILGMFSPYEYTWITPGKGLFQIGLFIASFLGLCYVVKLTYPDRVSYPREFEGGLERELGGAGAARMEGDPDPFLCLDDEIMWMVSLYCLPASKLISSPVALQDKSTSSASAMRYDDWDVILFPTGRDSKIPFKEFKVACHVVPDIELAHLHGAVGSPVMTCFVPSLPPGTPFQVSIHCWRRPEISQFARTYSKNPDLVKFEARVTLDGRLVASAILDRDVNGPHLITSTFEFTKTGELERLTFPAFRQEILRQNHWHPGDDLGRIKVIISEGFPRDSLTVPIERVKNIVTFSFQHAPLGKIPGIAWPNPGMWRRPTPNPAVSVPTYFPGDGAESHAHSPGKRSLLLKGIRNHGFPSTVIPGSIFHHQSNPAGLLNPPGFKVPHFSASNPSVPNIFSPHDPFAEPTYRDWMSSITNVQAGDFWDGRTTWPINPRNFHKSDTIMADCPSQGGDPMQISGSSLEDDPLRLKAPQNTPTEGGEGPNPGAQFAHPIPSELTADLESALSQSLLNQAPTSAISQRNFPMPHSDGLSRKEGRQVSLGQGTSAQMPSTSSSMEARRLSQALFGMNNLPIEASVNNGVSASVTPLFAANQRSVNNPLVATFGSAILSQGSTNPSGTEQSTDTTATTTAAAAAAVTDVQVEPPAPTSNAANESVINLTSGTSSTSTVHANVPTSVSKRPRNFTPASARVIDEEDEPRRTSPQVQVGGFAETTSVEESIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0RY62</accession>
    <name>G0RY62_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0005560</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691090.1">
        <property type="nucleotide sequence ID" value="XM_006691027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RY62"/>
    <dbReference type="GeneID" id="18254594"/>
    <dbReference type="KEGG" id="cthr:CTHT_0005560"/>
    <dbReference type="eggNOG" id="ENOG502SZVT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119146_0_0_1"/>
    <dbReference type="OMA" id="PSWPRRE"/>
    <dbReference type="OrthoDB" id="5294241at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="166" mass="18248" checksum="31FA3FF168E5F9FB" modified="2011-10-19" version="1">MYGSSYSSYSSSSSSTRSFFSPYSSPTTAVTTTIAIDIAPSPFSTQAPEASCAFPSWPRRSSLGGWDAPEDRPSCYFSDEELLEIDSFSEDDLSSHGGSPNQSPIPQQPQIDYEAAKRQVLRILALEQREQRRRAAMMGKKRRTSPSSKKSKGRTVSMMTPIAEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYB0</accession>
    <name>G0RYB0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cytokinesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0006050</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691138.1">
        <property type="nucleotide sequence ID" value="XM_006691075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYB0"/>
    <dbReference type="STRING" id="759272.G0RYB0"/>
    <dbReference type="GeneID" id="18254643"/>
    <dbReference type="KEGG" id="cthr:CTHT_0006050"/>
    <dbReference type="eggNOG" id="ENOG502QX1K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008906_0_0_1"/>
    <dbReference type="OMA" id="DWGEGSL"/>
    <dbReference type="OrthoDB" id="19159at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990334">
        <property type="term" value="C:Bfa1-Bub2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031578">
        <property type="term" value="P:mitotic spindle orientation checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034586">
        <property type="entry name" value="Bfa1/Byr4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35140">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BFA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35140:SF1">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BFA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="688"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="939"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="462"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="623"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="704"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1061" mass="116141" checksum="0282A84A66D415BC" modified="2011-10-19" version="1">METLRLKNRPPAPAEEEIENWDDDDFIIEGDDLTFTALVNSTNLSASRRDSQSSFRSEFESVGEEERQVHLPGNDEKSTLDAIAAAAQAGIPLPKNIPPSALMGGTIKRLGGRKIKKIIQEDWTEDLEFPEGVQNLKIKSRNTTPFPEALRQISTSATTSPRKPRDSLNLWEEPMKEKGSSSPGFIDLEKFRDAEDDDLFGDGLETIKVSKRRQPPKPLSLITPPTPQKEKCDDADDDFEKDFELPEDGTLKLTSRKDVPKTPTFNTLLEDLEWAEGSLGTRVGGTRRDLQSGHSSSISAFSPSIASSMTAESEDDTFDGLILPSGPLDFAERLRRRRQSRSPSRIPDEPIQEEEPVKQEPKEKPKQQDSEEDFLEGLDIGDGEIFDPRKLTLNRNIQVKETRPTSPARPKASVALKFTNKPTTASRLPRPTHERSHTQPTLEPVSETGGPISRTHTRRSLSRLGHASHSSVTSISSIATTTSPTPTPSSSHGATLATPRRNAGVQRSEPTTTSSQLLRMKRSMPVISKSQSPARGQATSTTRGHERPPSRTDQPTSRIPIRPKTPVERSRPVEDSATITRKAPPVPFVPAGASAEQSHNINAKARALRRHDSEASIDFRPTSRAVSRSAIRSPSPRRYRPISVIEKTPDGSSWSKLSLPRRVRNFGDGHELDAFDDLPTSSQAEARFLKQPVSGRSTIRTAVNNNNNNNNNNNNNSSSSSRSSSRPALPERTPPTTPFSSRYNDGNVPSFARDTTASRIARETNLAQRNASGIIAPLTAARVAQISARSNLLAPQTAASATTKAKKRRSPQAKPHLIANLNPPRESKMVKGMWYNPETYRWEGNDTVLSAFDRVSTASSTNTTSATLGSAGGSQFTPTLRGAGSGLGFLTDRDTASATPRPALITNIGASATKGVKVVGGMVFDPVNMCWLKVSHVRRGDSDDAGSDSDDPFKDIPDLEERTVASTATSDGIPGYMSGYGSGSGAGAGGGGSRYSDIKDDWLVGEEFDVGPEFVRRQREEEERWRRKCQVWVEQGRLVERGDAWKWAIREIVRQSAGGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYH3</accession>
    <name>G0RYH3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0006690</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691201.1">
        <property type="nucleotide sequence ID" value="XM_006691138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYH3"/>
    <dbReference type="GeneID" id="18254707"/>
    <dbReference type="KEGG" id="cthr:CTHT_0006690"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_34_10_1"/>
    <dbReference type="OMA" id="RELAYCI"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="17"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="256" mass="29415" checksum="32E3C308BFF73851" modified="2011-10-19" version="1">MDVYAQHKKYILQPSLSDLEEMFHAVAALYNDGVFVIVDALDECQMSDNVRSKFIEALLRLQSRESNVNLLATSRPVPDIVEAFYGHSCLEIVAQNNDIERYMRNQMSNWRVISKYPDLQDEIISCIVSVADGILICKIRFLLAHLFFKSLKNKVSAKRIRETLNKLRENSQEREPKLALLHQAYNDAMDRINGQPDDHKELANHVLSWIICAKRPLKTMEVQYAWAVRESEDEIDETAIPDAEDMLSLVPMGSTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYL9</accession>
    <name>G0RYL9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0007160</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS24005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691247.1">
        <property type="nucleotide sequence ID" value="XM_006691184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYL9"/>
    <dbReference type="STRING" id="759272.G0RYL9"/>
    <dbReference type="GeneID" id="18254754"/>
    <dbReference type="KEGG" id="cthr:CTHT_0007160"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_711725_0_0_1"/>
    <dbReference type="OMA" id="FMMTPTH"/>
    <dbReference type="OrthoDB" id="10018191at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS24005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="388" mass="42916" checksum="26F3A75BB2F8AC1D" modified="2011-10-19" version="1">MELSALQTCALQPRIEFEDDSDFGGHNNLAEGCSTANISKSSYAPSTYGPRTPSSGRSTPIRSASLDYASSFATTIDTPLDLTPPSSTTSTYFSTSMKVSSQTTDFLYPDLSFTPPRGQLDFSGHTFGNCGTQIASPQPTNSVFFINNYASQSFSVPTAIFGHVDQLSDSLWVRTDSPINFEERSLPRLMRPGVSTVKLGNSTDDIISPMSSSNVSRRRARIGEARLRSTALQQAQQTSSTLSTAQIQFKPESNAKKPHALVTESGCVTIENIQTGKFKCPYEGCKTRPYRRNEHLKRHIQCAHKGTLYPCDWCPKVVNRKDNWLSHIKLHTLPRGTAGRVRYEAGAVKQYEEEMRRIHSRRGSAKTKKRLETTAVVERMHADGGQSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYP1</accession>
    <name>G0RYP1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0007380</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS24027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691269.1">
        <property type="nucleotide sequence ID" value="XM_006691206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYP1"/>
    <dbReference type="GeneID" id="18254776"/>
    <dbReference type="KEGG" id="cthr:CTHT_0007380"/>
    <dbReference type="HOGENOM" id="CLU_509961_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS24027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="534" mass="57054" checksum="48529FE5AC35156F" modified="2011-10-19" version="1">MPQRPRKPVHRQSKPVKQDGHTDSGTATSSKDALSTSHGTYSKRSKENSILPRPRAILHQNPVPKPSKSGQNTCLHGLIGNYSSRAAANTTNTNSTISNATSSWSNAAVDLPVAHAAQGSKRGNAKADLFCEVSGSVRNKPESGGQNLNNTSLAPLPVTGPQGRRRGKNGKTSKPSSKRERGLEVMQRPQLGQPQNAVGLGLANVRSTIASLLETTASNDQQHKPHLLVTSDLLPTFPDNDQPNAKDQVAGPQTASLPNSKTKRSCGGRKTKQNTHSQHLCNTPNNHKRTSNESKSMSAETGATQNKAPAGASASHKLPVARRPQKRYKSSLEVASVLAAALAAATGAETTARATARGSMHQADKANEDGGSLEGPVCFTPADLLSEHNRRSLKSNQAVTVFPTGLLPPIEFDACPHTSSGYKLDWDEDRDACAALPPITDRKTTRKPVIKSAKKPSFKAKGNTRTKTNGKTNSEPPANTKRKKTAKLTTPEDKETRYLPVNAYLAPSNIDPNQLQATQLASLALQEVIEDPDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYP8</accession>
    <name>G0RYP8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">Mitochondrial escape protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CTHT_0007450</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 14">Plays a role in maintaining the mitochondrial genome and in controlling the mtDNA escape. Involved in the regulation of mtDNA nucleotide structure and number. May have a dispensable role in early maturation of pre-rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion inner membrane</location>
            <topology evidence="1 14">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the YME2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS24034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691276.1">
        <property type="nucleotide sequence ID" value="XM_006691213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYP8"/>
    <dbReference type="GeneID" id="18254783"/>
    <dbReference type="KEGG" id="cthr:CTHT_0007450"/>
    <dbReference type="eggNOG" id="ENOG502QS0P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007861_0_0_1"/>
    <dbReference type="OMA" id="WTPEQAW"/>
    <dbReference type="OrthoDB" id="10267654at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12433">
        <property type="entry name" value="RRM_Yme2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000959">
        <property type="entry name" value="Mitochondrial escape protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018850">
        <property type="entry name" value="Mt_escape_2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039627">
        <property type="entry name" value="Yme2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034260">
        <property type="entry name" value="Yme2_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32198">
        <property type="entry name" value="MITOCHONDRIAL ESCAPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32198:SF2">
        <property type="entry name" value="MITOCHONDRIAL ESCAPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10443">
        <property type="entry name" value="RNA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 14" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 14" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="128"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="717"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGS24034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="792" mass="88228" checksum="4A519ECC0BEAE491" modified="2011-10-19" version="1">MTLNLFPLKLSSVLLWSPWETNRDLASLLGRPEVAPSGLFDPVGLVKQAIPKDLPIKITQVIPRLKESGAYVKFTYPPGISPAEIEAKLVKSLIENPIKPWFSPFRGIKASLVQGRPWLEDLYRLPKGRLKVEFIPTGDGEPPGELSQESLYNLFRRYGKIADIVSQPPDSKVVPRYAYVDFVLVRDAIMARNCMHGFVLKEEGSKNPTRLRLSYEQRVKPHHFWSWISGHPKIVIPIIAAVLAAFTVAVFDPIREFFVQSHIQKSLDLTNSNLYKWLKRQTSDILSFKPRKEETAGLSALFTHHRELIDTVQSSLLESGDTFVVVHGPRGSGARELIMNQVLHDRRDVLLIDCRQVMEARGEADIIKKLASQVGYRPVFSWANNISSMLDLAIQSTTGVKAGFSENLEAQIVKILQTTASALKNVSLSARTKDDRDATLTDDAYLEAHPERRAVVVIDNFLHKGDEKGIFYDRLSDWAAALVQSNIAHVIFLTTDTTYSKTLSRALPDRVFHQVRLSDLSPDVAKRFVISQLNNQSQPQPGADDSRIKLSNQQLRSDLAELDECISLLGGRVTDLQLLARRLKAGQSPSKAVSDIIEQSSIEILRFFLLSTKPTTPSGADKKWSAEQAWSLIKALATSPNEALPYNQVLLSPTFAYSTSPDAASPEAALEALANAELITIHSRHGRPATIKAGKPVYQAAFRKLLEDPVVKARMDLAMLTELVKIENKNIEKAEAELAVLGQAGAQNGSWGWGLAGERVKYLLGKVKASQWRIEKWEGEIKGLKKVLEKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYU7</accession>
    <name>G0RYU7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Tryptophan synthase</fullName>
            <ecNumber evidence="5 13">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0000630</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + L-tryptophan + H2O</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the TrpB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the TrpA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="5 13"/>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690617.1">
        <property type="nucleotide sequence ID" value="XM_006690554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYU7"/>
    <dbReference type="STRING" id="759272.G0RYU7"/>
    <dbReference type="GeneID" id="18254101"/>
    <dbReference type="KEGG" id="cthr:CTHT_0000630"/>
    <dbReference type="eggNOG" id="KOG1395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016734_1_2_1"/>
    <dbReference type="OMA" id="FYPFLHE"/>
    <dbReference type="OrthoDB" id="10050244at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000151">
        <property type="entry name" value="Tryptophan synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000001">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000004">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018204">
        <property type="entry name" value="Trp_synthase_alpha_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077:SF3">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00167">
        <property type="entry name" value="TRP_SYNTHASE_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="14">
        <location>
            <begin position="358"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS23375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="704" mass="75998" checksum="A09A6290BFDBCD69" modified="2011-10-19" version="1">MEAIKRTFQRCKAEGRAALVTYVTAGFPKIEDTPHVLLAMEKGGADVIELGVPFTDPIADGPTIQTANTVALQNGVTIQTTLQMVRNARKLGLRAPILMMGYYNPLLNYGEERLINDCKEAGVNGFIIVDLPPEEAVSFRRLCTKGGLSYVPLIAPATSDARMRILCQLADSFIYVVSRQGVTGALGTLNAHLPDLLARVKKYSGDKPAAVGFGVSTHDHFLSVSNIADGVVVGSMIVTTLQKAAENEKYKAVQEFCSYLCGRNPAAEESASGADQNSADASVDGVAGDGEAEDLVAQLASMHGRLPERFGEFGGQYVPESLMDCLSELEEGFNKIKDDPNFWEEYRSYYHWMGRPGHLHKAERLSEYAGGATIWLKREDLNHTGSHKINNALGQLLLARRLGKTKIIAETGAGQHGVATATVCAKFGMECTIYMGAEDVRRQALNVFRMRLLGAKVVPVEAGSRTLRDAVNEALRAWVVNLEDTHYIIGSAIGPHPFPTIVRTFQSVIGNETKAQMLEQCGKLPDAVVACVGGGSNAVGMFYPFSSEPSVKLLGVEAGGDGIETNRHSATLTAGSKGVLHGVRTYVLQNEHGQIDETHSVSAGLDYPGVGPELSHWKDTGRAQFIAATDAQAFIGFRLMSQLEGIIPALESSHGIYGAIELAKTMRKDQNIVVCLSGRGDKDVQHVAEELPKIGPQIGWDLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYZ1</accession>
    <name>G0RYZ1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycoside hydrolase 131 catalytic N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0001080</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690661.1">
        <property type="nucleotide sequence ID" value="XM_006690598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYZ1"/>
    <dbReference type="STRING" id="759272.G0RYZ1"/>
    <dbReference type="GeneID" id="18254146"/>
    <dbReference type="KEGG" id="cthr:CTHT_0001080"/>
    <dbReference type="eggNOG" id="ENOG502QVJU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038296_0_0_1"/>
    <dbReference type="OMA" id="GQTMMRS"/>
    <dbReference type="OrthoDB" id="120072at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041524">
        <property type="entry name" value="GH131_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34612">
        <property type="entry name" value="GH131_N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34612:SF6">
        <property type="entry name" value="GLYCOSIDE HYDROLASE 131 CATALYTIC N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18271">
        <property type="entry name" value="GH131_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012090528" description="Glycoside hydrolase 131 catalytic N-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase 131 catalytic N-terminal" evidence="2">
        <location>
            <begin position="18"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="263" mass="29620" checksum="043DB6A71AA6ED10" modified="2011-10-19" version="1">MRLLTLATLTAPALGGNILWDGRFNDLSSSLDLNRWSWSNQVGPYQYYIHGSSPVTAYVNLSPSYKNPFDAGSKQGAKITLDRTAYWNGQNMRRTELIPQTTAPINRGKVYYHFSLMRKDVNAPATTREHQIAFFESHFTELKSGWLSGSPGTEDTKLRWCVSGQTHWSVEWEADVWHNFAYEIDFSAGTVGLWHSENGEPLKRVVDPVRTSASSDGKDWHVGVLELPRSGYNDFDEDFYFSGVYIENGEITTSVSGPGESPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZ46</accession>
    <name>G0RZ46_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0001670</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690716.1">
        <property type="nucleotide sequence ID" value="XM_006690653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZ46"/>
    <dbReference type="STRING" id="759272.G0RZ46"/>
    <dbReference type="GeneID" id="18254205"/>
    <dbReference type="KEGG" id="cthr:CTHT_0001670"/>
    <dbReference type="eggNOG" id="ENOG502RVW5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_541843_0_0_1"/>
    <dbReference type="OrthoDB" id="5244978at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="503" mass="52632" checksum="44805B27B096DECB" modified="2011-10-19" version="1">MDHFSSSPSPEDTCPCYINPSAIRPQRWQDDPQGCLRSCEAQFLQSIHQKWSLSDHWIDGCQKLNGTGPVRGFWALYWCDATFCGVGIDLNGGEGQDPNVDLIISTCANIGFPSILDPGPPPPTFHCATSAADLERCSAAAAADLPTTSSATIPASSDNISIAAVPTDPADTNSLSPSSAEPTSFIDPLPTETSTTSSSPLSSLGKAGVAIGSALAVVAIILCALLCLRRRKKLKNATNTNPSTFPDDDTLPIPGSGHTRKLSRATTLIGSPTPLISPARRGSTRTGGGRKFLESISILKVGSRRRSASASPPLTPLGPAPPPPAERYPNPTDGRLTPLMVRREGSLGQIRTAREEREDDAAALWLPIPHTSPGTTYLTTAESSVTSPSSSSPSSSSSAAAAAKRELEGEGNREECVVAGEGASSSRGGGSGLGAEVEFESRAGTEPGTEYISEGLWSEHKSMEKREKTGRKRGSASAAATKNAAVGGRVERKLGELGWDWEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZ77</accession>
    <name>G0RZ77_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acid phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0001990</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690747.1">
        <property type="nucleotide sequence ID" value="XM_006690684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZ77"/>
    <dbReference type="STRING" id="759272.G0RZ77"/>
    <dbReference type="GeneID" id="18254237"/>
    <dbReference type="KEGG" id="cthr:CTHT_0001990"/>
    <dbReference type="eggNOG" id="ENOG502QSRP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027977_2_1_1"/>
    <dbReference type="OMA" id="QFVFMSP"/>
    <dbReference type="OrthoDB" id="5135119at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000064">
        <property type="entry name" value="Probable acid phosphatase Pho610"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956:SF15">
        <property type="entry name" value="ACID PHOSPHATASE PHOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408660" evidence="2">
        <location>
            <begin position="29"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="394" mass="43744" checksum="76102721CE1426B9" modified="2011-10-19" version="1">MVVNHQGTMQRLLVLLVALACSVVGVVAIVPGKAFDRFITIWLENQDYDKVAIDATFKDLKRHGIFLTRYYAQTHPSQPNYIAAISGDYYGLNHDDMVRIPSNVATVVDLLESKNISWAGYFEDMPGPGYMGNASDGSTGNGAWDYVRKHNPFVSFDSITNEGERLLNLDSFDVFQRAFKARQVPQFVFMSPNMMNDGHNTTLEFATQWSHKFLEPLLADNAFDERTLIMLTYDESEDYSKPNHIATLLLGSAIPPKLKGTTDDTFYTHYSILSTIEANWKLPHLGRYDVGANVFQFVADWTGYTGNRDPPNAASVNNSLSYPGALNNDTMKVIGIPPPNTKLIGASGLGILDQIRAEWSIAATWKTPYDGSGKVFDGDKNLPVYAAPAPNHQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZC9</accession>
    <name>G0RZC9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NFACT RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0002520</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC25 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690799.1">
        <property type="nucleotide sequence ID" value="XM_006690736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZC9"/>
    <dbReference type="STRING" id="759272.G0RZC9"/>
    <dbReference type="GeneID" id="18254290"/>
    <dbReference type="KEGG" id="cthr:CTHT_0002520"/>
    <dbReference type="eggNOG" id="KOG3272">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076656_0_0_1"/>
    <dbReference type="OMA" id="YHDEKAV"/>
    <dbReference type="OrthoDB" id="200398at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039730">
        <property type="entry name" value="Jlp2/Ccd25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13049:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13049">
        <property type="entry name" value="DUF814-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT RNA-binding" evidence="4">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="137"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS23557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="199" mass="23653" checksum="F78629B64677E401" modified="2011-10-19" version="1">MVYYFTSNVVDPPAFIYVGKDKFENEDLIKYGWEEDVWLQEGQSWDNLPQELLNDLAQLTKANSIEGNKKDNITVIYTPWSNLRKDGSMDVGQVGFKDPKKVKRILVPTRENPIINRLNKTKVEKFPDLKQEKDDHLRELRKKDRAAQLERKKEEQRIARERAQLKWQKEHAYDDLFTEENMAGSSNQDRDENWEEDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZR7</accession>
    <name>G0RZR7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0003930</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690937.1">
        <property type="nucleotide sequence ID" value="XM_006690874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZR7"/>
    <dbReference type="STRING" id="759272.G0RZR7"/>
    <dbReference type="GeneID" id="18254431"/>
    <dbReference type="KEGG" id="cthr:CTHT_0003930"/>
    <dbReference type="eggNOG" id="ENOG502RJWB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1255846_0_0_1"/>
    <dbReference type="OrthoDB" id="366390at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="127"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="220" mass="24786" checksum="BFC11FAFC7CA985A" modified="2011-10-19" version="1">MANTSSLSAPQKDFIKMAPTEKRRADRIKLIDPTLLDIAPKRKPNVPDFFYAIPEPQVVTYPDKESTSSSDDSEHEPEDAPIRAAIEPTAAHRAAKAGDIAAVEHLAKNLGSDAARVRYFSTPTAHYNEYPVLLALRYGHWNVFKTLVENGANPHCTNAMKDTIYDWPEERGVYTKDDLDAIVRYWDRVYGSRFDELCGNTPKGRAVDGLRIPDDGRKYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZS1</accession>
    <name>G0RZS1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0003980</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690941.1">
        <property type="nucleotide sequence ID" value="XM_006690878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZS1"/>
    <dbReference type="GeneID" id="18254436"/>
    <dbReference type="KEGG" id="cthr:CTHT_0003980"/>
    <dbReference type="HOGENOM" id="CLU_2209736_0_0_1"/>
    <dbReference type="OrthoDB" id="3260716at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="107" mass="11279" checksum="FD27FEFEE44F2AC2" modified="2011-10-19" version="1">MDPSLRTSATDTLRGASSADVYNDSAFARPMGGQTSRELRSNRNEKRGLEGRGATATTSDETVEGRARALGADLPEGVERGIRDKGPGAEDRQPASATEIASEKSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZY8</accession>
    <name>G0RZY8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0008100</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691340.1">
        <property type="nucleotide sequence ID" value="XM_006691277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZY8"/>
    <dbReference type="GeneID" id="18254848"/>
    <dbReference type="KEGG" id="cthr:CTHT_0008100"/>
    <dbReference type="eggNOG" id="ENOG502SVSE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075611_0_0_1"/>
    <dbReference type="OMA" id="REEDKQW"/>
    <dbReference type="OrthoDB" id="4203030at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="316" mass="35179" checksum="04FA6F8E96E78F31" modified="2011-10-19" version="1">MASVINDEAPSYRPSAVETLSPEDFETASIRSAAPSYTLWMLNVPQASEAPSYHSTVIPNEPLPPYSPPGEAPPMHTILDSNVPARLRSGSQNSSSNSSSTPRSTPSMSVTSLLDIDAPPRRSSAPTTPPTTNSSASTSQAPRRSSTNSMPSLDHFRIPSWSPASATRSNPNARIYHNVALRRAAAAAAATNNRNSSSVDNLSDRLRRAMVLSRIAEEESGSEGHARGSGEGQRAFRPQEDPWLVGEEAAERARRERLERERYLGEEVLLREDRKWDWFLAQIREREEQEKVWRRLRQEMGRRPNNRFAFLIGSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0I9</accession>
    <name>G0S0I9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Protein phosphatase PP2A regulatory subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0010180</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Phosphatase 2A affects a variety of biological processes in the cell such as transcription, cell cycle progression and cellular morphogenesis, and provides an initial identification of critical substrates for this phosphatase. The regulatory subunit may direct the catalytic subunit to distinct, albeit overlapping, subsets of substrates.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691541.1">
        <property type="nucleotide sequence ID" value="XM_006691478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0I9"/>
    <dbReference type="STRING" id="759272.G0S0I9"/>
    <dbReference type="GeneID" id="18255056"/>
    <dbReference type="KEGG" id="cthr:CTHT_0010180"/>
    <dbReference type="eggNOG" id="KOG1354">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021713_3_3_1"/>
    <dbReference type="OMA" id="NQIKWCR"/>
    <dbReference type="OrthoDB" id="6274823at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000174">
        <property type="entry name" value="Protein phosphatase PP2A regulatory subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000189">
        <property type="entry name" value="Protein phosphatase PP2A regulatory subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000009">
        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018067">
        <property type="entry name" value="PP2A_PR55_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11871">
        <property type="entry name" value="PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037309">
        <property type="entry name" value="PP2A_PR55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00600">
        <property type="entry name" value="PP2APR55"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01024">
        <property type="entry name" value="PR55_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01025">
        <property type="entry name" value="PR55_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="402"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00055525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU331113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS23350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="477" mass="53841" checksum="3555AC457E3C3693" modified="2011-10-19" version="1">MVETDTNGPTWKFTQCFGDKGDVEDITEADIISTVEFDHTGNYLATGDKGGRVVLFERNETKKTCEYKFHTEFQSHEPEFDYLKSLEIEEKINKIKWCRRQNAAHFLLSTNDKTIKLWKVFEKSLKVVAENNLSQDLTPGGIAGGGGRPVPIKFRSPNDLKLPRLTHHDTVVAAVPRRVYANAHAYHINSISVNSDGETFISSDDLRINLWNLNIQDQSFNIVDIKPANMEELTEVITAAEFHPISCNWFMYASSKGTIKLADMRQSALCDQHAKLFEQEEDPASRSFFSEIISSISDVRFSYDGRYILSRDYLTVKIWDINMERQPIKTIPIHEHLRPRLCDTYENDSIFDKFEVVFSGDGKNVMTGSYNNNFMIYPSDPDKEVEIVLQADKSAFKAKKVGVPQPIGSSTSPTANGKKGGSRAGSPAAPGLGQRMRKETDADQIDFNKKILHMSWHPFEDSIAIAATNNLFVFSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0M7</accession>
    <name>G0S0M7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclear distribution protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0010570</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691579.1">
        <property type="nucleotide sequence ID" value="XM_006691516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0M7"/>
    <dbReference type="STRING" id="759272.G0S0M7"/>
    <dbReference type="GeneID" id="18255095"/>
    <dbReference type="KEGG" id="cthr:CTHT_0010570"/>
    <dbReference type="eggNOG" id="ENOG502S5XV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091042_0_0_1"/>
    <dbReference type="OMA" id="WYEVGLV"/>
    <dbReference type="OrthoDB" id="5403729at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS22587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="21727" checksum="E4587C3442958391" modified="2011-10-19" version="1">MDRSLDQTTLETIALLESRLHRLERLLYGPAAPPSQPPKKSVLRSLADLERRFAHLIRHYRAHPSLFQPSSSTPTKEPPTQLSPDAVLQTVLSYASSFPATASALTAATSDETIPDAAQSAALAALVPRMRATETTQLAQAAEIAELRKRSEVVLKAWYTGCVLRHGEKVAELEKRLEGVEVGIRRAKRVKDLEEKV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-06-24" modified="2025-04-09" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0R2</accession>
    <accession>G0ZGU2</accession>
    <name>NUP57_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleoporin NUP57</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Nuclear pore protein NUP57</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">NUP57</name>
        <name type="ORF">CTHT_0010940</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). NUP57 plays an important role in several nuclear transport pathways including poly(A)+ RNA, tRNA, and pre-ribosome transport.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 6">Component of the nuclear pore complex (NPC). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Nucleoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="1">Symmetric distribution.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited. FG repeat types and their physico-chemical environment change across the NPC from the nucleoplasmic to the cytoplasmic side: GLFG repeats are especially abundant in NUPs in the central region (lacking a charged environment but are enriched in Ser, Thr, Gln, and Asn).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nucleoporin GLFG family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JF276283">
        <property type="protein sequence ID" value="AEL00680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691614.1">
        <property type="nucleotide sequence ID" value="XM_006691551.1"/>
    </dbReference>
    <dbReference type="PDB" id="5CWS">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.77 A"/>
        <property type="chains" value="E/K=74-319"/>
    </dbReference>
    <dbReference type="PDB" id="5CWT">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.50 A"/>
        <property type="chains" value="A/B/C/D=265-317"/>
    </dbReference>
    <dbReference type="PDBsum" id="5CWS"/>
    <dbReference type="PDBsum" id="5CWT"/>
    <dbReference type="AlphaFoldDB" id="G0S0R2"/>
    <dbReference type="SMR" id="G0S0R2"/>
    <dbReference type="DIP" id="DIP-61840N"/>
    <dbReference type="IntAct" id="G0S0R2">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S0R2"/>
    <dbReference type="TCDB" id="1.I.1.1.2">
        <property type="family name" value="the nuclear pore complex (npc) family"/>
    </dbReference>
    <dbReference type="ABCD" id="G0S0R2">
        <property type="antibodies" value="1 sequenced antibody"/>
    </dbReference>
    <dbReference type="GeneID" id="18255132"/>
    <dbReference type="KEGG" id="cthr:CTHT_0010940"/>
    <dbReference type="eggNOG" id="KOG3091">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023804_0_0_1"/>
    <dbReference type="OMA" id="SCVFKHY"/>
    <dbReference type="OrthoDB" id="6162375at2759"/>
    <dbReference type="EvolutionaryTrace" id="G0S0R2"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.3600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.490">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024864">
        <property type="entry name" value="Nup54/Nup57/Nup44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025712">
        <property type="entry name" value="Nup54_alpha-helical_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000">
        <property type="entry name" value="NUCLEOPORIN P54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000:SF0">
        <property type="entry name" value="NUCLEOPORIN P54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13874">
        <property type="entry name" value="Nup54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18570">
        <property type="entry name" value="Nup54_57_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0509">mRNA transport</keyword>
    <keyword id="KW-0906">Nuclear pore complex</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000433177" description="Nucleoporin NUP57">
        <location>
            <begin position="1"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="repeat" description="SLFG">
        <location>
            <begin position="13"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="repeat" description="GLFG">
        <location>
            <begin position="22"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="280"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="helix" evidence="7">
        <location>
            <begin position="278"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P48837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="21784248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <evidence type="ECO:0000305" key="6">
        <source>
            <dbReference type="PubMed" id="21784248"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="5CWT"/>
        </source>
    </evidence>
    <sequence length="326" mass="36922" checksum="5DAE08CD802C768F" modified="2011-10-19" version="1">MFSSLNTRPAGQSLFGANTGGGLFGQSLANQPQQQQQPLQQQQQQAAPALGQSQINQNQQLGGSLWQPGSLTAYQKPIPEQIKLIVDKWNPNHPNCAFKTYLYNKVDEHTVPLYGPGPNEDPKEWEEALQRKPAPNFIPVLCSGFPSIVARLMLQRRVITEFNNKLHQINASLDAILSRHDLDHTVRAFNARRRHAELSRRCLHLAARVQVLRNRGYALSGDEDELKQKLQQIDKTLNDPAQGSRLEELWSRLIVLRGYAEDLKDQINQAGITESDGLGEEIEAKAKKILEDYDKQLQHLKKQVEEAKKDFEEWEKQHNPAPAPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0S5</accession>
    <name>G0S0S5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0011070</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691627.1">
        <property type="nucleotide sequence ID" value="XM_006691564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0S5"/>
    <dbReference type="STRING" id="759272.G0S0S5"/>
    <dbReference type="GeneID" id="18255145"/>
    <dbReference type="KEGG" id="cthr:CTHT_0011070"/>
    <dbReference type="eggNOG" id="KOG3232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125118_0_0_1"/>
    <dbReference type="OMA" id="QQITMVM"/>
    <dbReference type="OrthoDB" id="10266568at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="209" mass="22983" checksum="340DC9CAEA608603" modified="2011-10-19" version="1">MMSNRQLAKDLQLEFQARFNAKQARREALKAQKQDNELKKQIQNLLKKGETAQAAQKARMLLAKQAIAAQMDQAADMAELSLAQIQANNAMNRMTAMMQASSRTMARAQAAANPERTLLTLEQFRAQNEEYAMSSGIYQDALTQSTSVQVSDDAVQELLGKLADDAGLQLGAELNAASASKVDPASMQKEEPSQEVEDALQQRLRALRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1H5</accession>
    <name>G0S1H5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative amino acid transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0013620</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691877.1">
        <property type="nucleotide sequence ID" value="XM_006691814.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S1H5"/>
    <dbReference type="GeneID" id="18255400"/>
    <dbReference type="KEGG" id="cthr:CTHT_0013620"/>
    <dbReference type="eggNOG" id="KOG1305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_241478_0_0_1"/>
    <dbReference type="OMA" id="RERYEFT"/>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF458">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="344"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="444"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="530"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="216"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="CHAT" evidence="11">
        <location>
            <begin position="1333"/>
            <end position="1680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS22885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1681" mass="186482" checksum="84066B8D71256C86" modified="2011-10-19" version="1">MTRAGAHGATAAKNSSDTGSRQGDGEEGVGLLAAAAHTQDEDSYHYPGQDQKSTPRPKGPAKPLQLQPQERLIVHPGEDDDDNSLVSLPLRTPRTPNRVRFDLRPTIVENNSRYSTDTTTTASESRSAQAQNGHTRSRESLDFDPDPDLDFDFDLDDPLSSRHRSERGSNGSHAHRQQRIPLLTGIEAPSVTVSNQLFGEHESAEAWHLAEQRRPKSSLPAAFMNMANSIIGAGIIGQPYAMRQAGLGAGIVLLVVLTVVVDWTIRLIVINSKLSGATSFQGTVERCFGRTGLIAISVAQWAFAFGGMVAFGVIVGDSIPSVLRQIWPGLKDVPVLGVLADRRWVIVVFTIGVSYPLALYRDIAKLAKASSLALLSMAVIVVTVVVQGMLVPSEDRGQLKDWKMLVVNDGIFQAIGVISFAFVCHHNSLLIYGSLEKPTMDRFAVVTHFSTGISMLACLLMALSGFLIFGDRTLGNVLNNFPSDNTMVNIARLCFGLNMLTTLPLEAFVCREVMLNYYFPGEPFSMNLHLLFTTSLVFSAMVLSLLTCDLGSVFDLVGGTSAAAMAYILPPLCYARGIQSSAIEHQHIYTSSNAFPGLFWACFEIEPQARARALQNLGRALTIKYSKSAVPVEEYFVEARQALDQATACYNSIRDQCACWYHLGALYAARYRWTEAEEDRQEGTRFASLAYENSPKQQPTSVLSFSLLAELRKSRNKFIDAWRTFSALRSPEMRFDSKSPEVMEEMGRLLSIEYAIVASADCVDNAVVYLTEILDSVPSNDPLLYTGLCVLGDLLFARYGFHERATDYDDVIQFGEMAMSSDDNEPLITEFLLIRTMLCNQRFRVTGDITKINEAIQLMRKKLFVDSSKGRSNPLNTFALGNCLRERYEFTNALGDLEEAIQWQRQAMREAPEHHMFAARMHFYMSEILKKQYQRTMELASLNEAIEHMRMASSSPGPHSYHPEVKLLYNCSLAELHLQKYNATNDTEHLTEALSLVHTIFEEKLSGEAAQAHGLAVDTIGSIYRTLYEKTGDSSYLLEAIATYERATNQGAKLPMSHRSRSRLLSNLTWLYLRRGEETRDLGYLSKALEYCEKILKDNNAAAAERVEAGRTYLTNIVKLQQWEAAYKAANLTASLVPQLSLRSLRHSDRKQLLANLYGLASEAAGVALRAGKSPLDVLRLVEQTRGIIGASLEQLRADMSRLKDVDPELARDFAKAQQQLTSPIHQEDWSPALFDKTSSWAHRDFEERQKFDEILSRIQQTPGFENFLRPLSEAKIFEAASRGPVVVISVAPFGCDALLVTANGVRAVPLPDLSHSEVVSKAQNGDFGSYDTLEWLWMTVARPILDALGFTQRYQDSGNGSNSMPPHIWWIPTGPLTNFPLHAAGLHRARTGQTVLDRVMSSYASSITSLIHVRERWFLLPPAPSDSTSGIDGISNQVLLVAMEETPGVARHAVLPFAAKEVEVVRQLCTSMGLSPISPGGHKQTIARYLRSCQFFHFAGHGATDPVNAENSRLLLLPDNDAPANNLDDGTPTNDGSLRVSEILDMDLTSNPTHPPPFLAYLSACGTGSMRDVRVADESIHLANAFQLAGFRHVLGTFWEVLDKMCVDVTRFVYERLLRDWKSGDLTDDSVCRALHEALRRVRDREVDEIFRGVTRSVRDVVLCEEEDVAAWAPYVHFGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1H8</accession>
    <name>G0S1H8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GTP-binding protein rho1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0013650</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691880.1">
        <property type="nucleotide sequence ID" value="XM_006691817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1H8"/>
    <dbReference type="STRING" id="759272.G0S1H8"/>
    <dbReference type="GeneID" id="18255403"/>
    <dbReference type="KEGG" id="cthr:CTHT_0013650"/>
    <dbReference type="eggNOG" id="KOG0393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_21_2_1"/>
    <dbReference type="OMA" id="EVNHYIP"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01870">
        <property type="entry name" value="RhoA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000329">
        <property type="entry name" value="GTP-binding protein rhoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS22888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="194" mass="21643" checksum="0D4EEB642A22D497" modified="2011-10-19" version="1">MTAELRRKLVIVGDGACGKTCLLIVFSKGTFPEVYVPTVFENYVADVEVDGKHVELALWDTAGQEDYDRLRPLSYPDSHVILICFAIDSPDSLDNVGEKWCSEVHHFCPDVPKLLVGCKKDLRFDPKTIEELRKISQQPVTPEQGQTVANNIKATKYLECSAKTNEGVREVFETATRAALLKKTGKKKNKCVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1I5</accession>
    <name>G0S1I5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0013720</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691887.1">
        <property type="nucleotide sequence ID" value="XM_006691824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1I5"/>
    <dbReference type="GeneID" id="18255410"/>
    <dbReference type="KEGG" id="cthr:CTHT_0013720"/>
    <dbReference type="HOGENOM" id="CLU_2440649_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="55"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="90" mass="10161" checksum="04E32F7FA792D7BF" modified="2011-10-19" version="1">MAPRRSLDLVTLILNAPQLIRLTFIVLPWDFFLRGLYLCSALTLYGLIVATVAILRVANRLLVVLQNLRRRLEELRVQMGDVSGVSILEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1J8</accession>
    <name>G0S1J8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative hsp70 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0013860</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691900.1">
        <property type="nucleotide sequence ID" value="XM_006691837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1J8"/>
    <dbReference type="STRING" id="759272.G0S1J8"/>
    <dbReference type="GeneID" id="18255424"/>
    <dbReference type="KEGG" id="cthr:CTHT_0013860"/>
    <dbReference type="eggNOG" id="KOG0101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009958_6_1_1"/>
    <dbReference type="OMA" id="IYKHTME"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF82">
        <property type="entry name" value="FAMILY CHAPERONE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G08575)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="441"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS22908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="655" mass="72852" checksum="41C9685FB16D7158" modified="2011-10-19" version="1">MSLPLPLHTSSSQRNRESRSYYTTQTRSPASAEGKSINGAATTDVKEEKPRSKERIIVGVDFGTTFSGVAAAYTGAPDEIEIIKTWPGGNGITSDKVPTELSYEPAPPNSPPGTPPTVKWGFQFRPEEPRLRCIKLFLDRAQKLPFYVSPLETASQLRKNKKTVVDAVADYLTQIRKHTMDTLRRRYGEGLVASTPVDWVLTCPAVWSDAAKNTTLLAAERAGMGEKSQIRMISEPEAAAVYTLKAIQLQPTHLKVGDNLIVCDAGGGTVDLIAYKIVSLTPLRVEESAVGTGGLCGSAFLNYRFEEHVKSRLGQTRFDELKTKKAKSWQMALKYFEEFVKRSFNEDEHQEVNIPLPGLPDDEAAGLDSGFLLLTSSQVKSIFDPIIKEVCDLVQGQVDVLRRKGAIVSGIILVGGFGQSDYLYRRLRAHFAPAYDDEGTIPPPPPYTELPTNPPPPDPLADRPLPIEVMQPIHAWTAVVRGAVLRGLESGSSTVLSRRARMHYGTSYATVYDETKHPVTERYWSPLWERWMVSDRMQWHIRKGEPISPTNPIAFHYTRNFRPGQSMVVTDDLIACEADDPPDRYTRDLIHVCTLTTDLSAVPRHLFTKLTTTRGVEFLNLDFTLEMTVDSAGLGFELKVDGVRYGRVEAEFHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1R3</accession>
    <name>G0S1R3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fucose-specific lectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0014520</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691965.1">
        <property type="nucleotide sequence ID" value="XM_006691902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1R3"/>
    <dbReference type="GeneID" id="18255490"/>
    <dbReference type="KEGG" id="cthr:CTHT_0014520"/>
    <dbReference type="eggNOG" id="ENOG502RVY9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028617_1_0_1"/>
    <dbReference type="OMA" id="NEWEEYT"/>
    <dbReference type="OrthoDB" id="4696326at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.70">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="422" mass="46150" checksum="297CB0726A624507" modified="2011-10-19" version="1">MAHRWLGLGGIPKPIQSRASICRDAPSIHSNSGLAAIVLGESDGFRVYYHDKDGAINELKYDPKRDEWSHNGFITKDISSLPALAATFTSKENITVVAPRDDKTIGVTRYQKDGDWQRTTFPYPLDSDIGVTQETDRTNITVDTTAAVNFTLPAWDGAPRGIGISVDREHTRSVWYIGTDRALHSAYNGDWVWHLRENQTEEIWPLADKPNAELAVAEIANKNTVFVYYIVNGKLAEIKYLNDAWQPWNHVPEPPPIPTTTNTAPESTITFAGDGNNGDDDSSGLSTGAKAGIGVGVSLGAIALGAIIAVLFLIRRKHKQQQQTPQYTPFSETASGTLAPDTPAPAYGTPSTAVVAPDGTVLNGDFVWAQKEGTYGLAPEVTELDGRERSAELDARPVYELPHQPYPHSEELQAREPKPKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1T1</accession>
    <name>G0S1T1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Aspartate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="4">1.2.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CTHT_0014710</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the NADPH-dependent formation of L-aspartate 4-semialdehyde (L-ASA) by the reductive dephosphorylation of 4-phospho-L-aspartate. Mediates the second step in the biosynthesis of amino acids that derive from aspartate (the aspartate family of amino acids), including methioinine and threonine, the latter of which is a precursor to isoleucine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-aspartate 4-semialdehyde + phosphate + NADP(+) = 4-phospho-L-aspartate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:24286"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="4"/>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691983.1">
        <property type="nucleotide sequence ID" value="XM_006691920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1T1"/>
    <dbReference type="STRING" id="759272.G0S1T1"/>
    <dbReference type="GeneID" id="18255509"/>
    <dbReference type="KEGG" id="cthr:CTHT_0014710"/>
    <dbReference type="eggNOG" id="KOG4777">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049966_1_0_1"/>
    <dbReference type="OMA" id="CEEEMKM"/>
    <dbReference type="OrthoDB" id="1894490at2759"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00016"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18130">
        <property type="entry name" value="ASADH_C_arch_fung_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02315">
        <property type="entry name" value="ScASADH_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000200">
        <property type="entry name" value="Aspartate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000016">
        <property type="entry name" value="Probable aspartate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051823">
        <property type="entry name" value="ASADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000319">
        <property type="entry name" value="Asp-semialdehyde_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005676">
        <property type="entry name" value="Asp_semi-ald_DH_pep-lack"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00978">
        <property type="entry name" value="asd_EA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006416">
        <property type="entry name" value="PRK08664.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46718">
        <property type="entry name" value="ASPARTATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46718:SF1">
        <property type="entry name" value="ASPARTATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000148">
        <property type="entry name" value="ASA_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01103">
        <property type="entry name" value="ASD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdehyde dehydrogenase NAD-binding" evidence="16">
        <location>
            <begin position="8"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="296"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="14">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000148-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGS22991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="362" mass="39262" checksum="EA8800D346196F1C" modified="2011-10-19" version="1">MSQLPVKKCGVLGCTGSVGQRFILLLQEHPSFKLVAVGASSRSAGKKYRDAVRWKQAKPMLPEVGELVVRECKASEFADCDIVFSGLDSDVAGEIEKEFQNANLAVFSNAKNYRRDPLVPLVVPTVNLDHLEMIHHQRRTLGLQKGFLVCNSNCAVIGLVIPFAALQARFGKIDTVSVVTMQAVSGAGYPGVSSMDIIDNVVPYIAGEEDKLETEAQKILGNLNADATAFEEQKTLRVSAACNRVPVMDGHTACVSLRFVQRPPPTADQVKEALREYVSEAQRLGCPSAPNPPIRVFDEPDRPQPRLDRDLSNGYTVSVGRVREDESGIFDIKFVALSHNTVIGAAGSSILNAEAAVLKGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1Z9</accession>
    <name>G0S1Z9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0015440</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS23059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692051.1">
        <property type="nucleotide sequence ID" value="XM_006691988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1Z9"/>
    <dbReference type="GeneID" id="18255582"/>
    <dbReference type="KEGG" id="cthr:CTHT_0015440"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_299159_0_0_1"/>
    <dbReference type="OMA" id="HTIISAY"/>
    <dbReference type="OrthoDB" id="4573812at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="952"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="81"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="148"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="510"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="817"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="510"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="523"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="819"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS23059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1003" mass="112416" checksum="A2042FD1D1632CA2" modified="2011-10-19" version="1">MFTFKPLLQALSQRDRPGFFRTLSEHPDIVNQDVGGRYGGTIVHEIIRQNNLEGAEKPGWLDLLTQVSGSPAVDWNLRDKAGRTPLLLAIENDLFEVSRFLLAHNADVGISDASDCCALHYAIHTRNKELLALLLSHAADTVDQKDKDGMTPLHLACALNQADMAEMLITEGADVNAKSKTGETPLHVAADQNAVEAARVLLRYDALRISPNQSKDTPEMVARDNGHQDMVDLLRTPVDISSPQRQPRPCRVRVPKPSQKQTMVAEKFKGLVWPAVEGDTVGNRKYTEMSIFEMLYQKYPEPKLGPHVRNRVRWIHIPANNSVWIQDVFKRLYSSDQSGNNEKQKTGGSSLNEQQNSDATVFQQIRRFINNQFAELETLSQHRYPQVKIAYGKRSEKDSFPMLALVLPVIDVDLQQPAYYKPPDVISTTPGKPTPASLKDQPPEEELRAHIAKLQELREAYPDAVEKSRTLDGYIHPFMDETNLHFRNGDQVVSRFIERDRRTYAEKLRKQVRAMKADKASDSSRTSSSRDSNSAIKQVVEDPNGVKTTVRLATGEMNIPISPAQLESQTWPVTRRSPWGSWHLKLRRSWSDLEEFFSKRRWRDSDSESEEDQAGEETTEKEIQALANEKIVRQQILTVPQLWLWRIEGTVVTSFPENYRLTQGHNSAFPLSQAILNALLQIPVPGDLDASQLVNLIISTCLDFEPKLLMSKARRAYLDAFGDEIAYVSSKVTTCYESFRRDMPADIPSTPTAGGTIAHFQPAMQGEMGLLVRIDDILGEIAMIQRVHHDQDRVCLLLQTATRNAAAANGSTDGMYMASSWGDSQSPQSSQAPDMAPLSSARPVRSNSMPLWGDEGSGNGSRWNGEFQVAQAQTECSGSGNEFQSQSFTGLNKLRSDKSKYLVSRLDRLAEDATRVRNSIITLLDLRQRQAITENALSSATQEDLLFSQSNILFVFTVATVIFAPLAWISGVMELNIKGFTPEDEAWTVGTLVWASREYHSCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0S268</accession>
    <name>G0S268_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VanZ-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0016170</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692120.1">
        <property type="nucleotide sequence ID" value="XM_006692057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S268"/>
    <dbReference type="GeneID" id="18255655"/>
    <dbReference type="KEGG" id="cthr:CTHT_0016170"/>
    <dbReference type="eggNOG" id="ENOG502S56A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096870_0_0_1"/>
    <dbReference type="OMA" id="FYWVLDT"/>
    <dbReference type="OrthoDB" id="63581at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037970">
        <property type="entry name" value="vanZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28008">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28008:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ-like" evidence="3">
        <location>
            <begin position="35"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS22101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="219" mass="23970" checksum="7ACDE518DF765365" modified="2011-10-19" version="1">MRIRLPILGAFALLSLLLAYLGLAPLSLSSLPVSDKFLHFIAFLFLTPLFYFTIDTTRRRAFNLTLTICVLGLGIASEVVQGWIPNGRDFDVFDVAANLVGGGVGLGVSMWYHKRMLERKRRRRYTAVPQEGVPQEDVDVELGEGGLSRTEDGHEEGIITTTATTTPAQQGISGEEDLDGWDNDVQSWDEEDVSEGQEGTASAAVTAGQKKDDVKKHSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0S276</accession>
    <name>G0S276_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0016250</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692128.1">
        <property type="nucleotide sequence ID" value="XM_006692065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S276"/>
    <dbReference type="STRING" id="759272.G0S276"/>
    <dbReference type="GeneID" id="18255663"/>
    <dbReference type="KEGG" id="cthr:CTHT_0016250"/>
    <dbReference type="eggNOG" id="KOG1426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021989_1_0_1"/>
    <dbReference type="OMA" id="YDQPHEI"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053245">
        <property type="entry name" value="MitoProcess-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47563">
        <property type="entry name" value="PROTEIN FMP25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47563:SF1">
        <property type="entry name" value="PROTEIN FMP25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="280"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="345"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="598" mass="64496" checksum="B68892EDA3F1139A" modified="2011-10-19" version="1">MAPLLRILRQPVRTLPRHWARYISSQPEPEFQPIRRSGTKIATLLGVFAASGAGVLFAYPRLFPKETSDSIPPKGPQRAEIIFEKPHKKLHTKEETREDISPQHVQVKHSWEHPGVYAWGSNAGKVVAPESKETVVKSPRRIKYFDGQILRDLKLDSQFGVAVNEQGDLVQWGAGYCKEEPGPRVTLKGKDLRKVAISKDRIIALGGDGKVYSIPVSKADQELGEKPKESGKSLLGSIWNNTSEHPLNYRLLKPSSLGLNEKVVDVQSGLEHCLLLTSKGRVFSAAASSEAFPSRGQLGVPGLTWETRPQGVPYDTPHEVKGLEGLKITAIAAGDYHSLALDSTGRAFAFGDNTFGQLGVEPEGGVYSVDAPVIVPLAQRYEHSNQVPKITSIAAGGGNSFFTVDAIPKEKSSSKNPSSVTTDLWSCGSGLRGTLGTGKFAHMSPTLTKIKSLSNLTEYDESLNRLVPIRIASVSVGSDHAAAVLGNKTHLTASASTPVSDTNFGADVLWWGGNEHYQLGTGKRNNVAIPVHIAPLDGERFEKGVPAQGGGDVKAGELRQRLQITPRTKVKIGEKGREVSVEQKVICGRGVSGVYSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2R7</accession>
    <name>G0S2R7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Gylcosyl hydrolase 115 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0018210</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692319.1">
        <property type="nucleotide sequence ID" value="XM_006692256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2R7"/>
    <dbReference type="GeneID" id="18255859"/>
    <dbReference type="KEGG" id="cthr:CTHT_0018210"/>
    <dbReference type="eggNOG" id="ENOG502QTU7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004852_1_0_1"/>
    <dbReference type="OMA" id="GPRNYKW"/>
    <dbReference type="OrthoDB" id="4849794at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.520">
        <property type="entry name" value="Glycosyl hydrolase family 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031924">
        <property type="entry name" value="GH115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041437">
        <property type="entry name" value="GH115_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042301">
        <property type="entry name" value="GH115_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37842">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37842:SF2">
        <property type="entry name" value="GYLCOSYL HYDROLASE 115 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17829">
        <property type="entry name" value="GH115_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15979">
        <property type="entry name" value="Glyco_hydro_115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408775" description="Gylcosyl hydrolase 115 C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="domain" description="Gylcosyl hydrolase 115 C-terminal" evidence="3">
        <location>
            <begin position="849"/>
            <end position="1040"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS22300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1073" mass="119244" checksum="E6B5546C323CE420" modified="2011-10-19" version="1">MKLLTWAALTAALFPLAHALGQERIISTDPKGSVLQLAGGRIKRGQILVSPNDYWGVIRAAGDLALDFGRVTGVNYTLSNGQRGSRPAVYTYRPVDNTDNVNYKTTGVANFTGPAYSDPSPADTVIIAGTIGNSTLIDKLISSKLLDVSAIRGKWESFTSQVITSPIPGCPKALVIAGSDPRGTIYGIYDISEQIGVSPWYFWADSPVRKSKNLYVTKQKKVQGPPSVKYRGLFLNDEQPALTNWVASRWKDTPYGPGYGAEFYSLVFELILRLRANYLWPAIWATMFEVDDPRNQPLADAYEVVIGSSHTEPLMRAQNEFGKFYEGPWAYNLNNKTIDEYFRYGVQRAKPYARNSLWTMGMRGTGDTAIEGLGVEHIVSMLNTLVQNQRQIISEGLDGVDITTVPQMWCLYKEVMTYLFYGLQVPDDVTLLWADDNAGNVRRLPLKSEQGRAGGAGVYYHFDYVGGPRNYKWINTVQLSKTTEQMHLSYARGADRIWIVNVGDLKALEIPINHYFDLAYDIRRWGLDSTFDWAKAYAEREFGAQFAADIADVMMKYAMYAGRRRFELLEPHVYSVINYNEADAILQQWAELSAKAQAIYDRLPADAKPSFFQTVLHPALAGEIVHKIQIGAAKNRLYAGQWRNAANKQIQEVLTLSAADANLTKRWDALLDGKWKHFMDQTHLGYDGYWQQPMRNALPPLVYVQPDFVALSGEVGFGVEANNGTVPGDDRYHPNSGASLTLPPLDPYGPVTRYFDVFSRGVRECTWKAAVAQPWVKLSRAEGRVGPNLADQRVYVSIDWSRAPKAPFEQTIAINVSSPCRDMDRYGFPEPVLYLPVQNRVVPSSFKKGFVESDKHVSMLGAHYSRIIPPKERTAENVNVTYHIFEHYGRTSSAVGLVPLTTEKLTVDTAPGLEYDLYLWTNTSSAKVTVFISPSLNYLGDDTPLEYAISLAPASSSSSYDIKSVRPVGPTVGTGMPAGWDGAVADNVWGRHENYTVSTFAVPEAGAYKLRLWALMPSILVQKIVIDLGGARQSYLGPPESFLVGRDAVGGRRNATSFLNEVGTVGGWSSKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2Y9</accession>
    <name>G0S2Y9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">squalene monooxygenase</fullName>
            <ecNumber evidence="4">1.14.14.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0018980</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the squalene monooxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.17" evidence="4"/>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692391.1">
        <property type="nucleotide sequence ID" value="XM_006692328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2Y9"/>
    <dbReference type="STRING" id="759272.G0S2Y9"/>
    <dbReference type="GeneID" id="18255936"/>
    <dbReference type="KEGG" id="cthr:CTHT_0018980"/>
    <dbReference type="eggNOG" id="KOG1298">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_390792_0_0_1"/>
    <dbReference type="OrthoDB" id="3061561at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004506">
        <property type="term" value="F:squalene monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013698">
        <property type="entry name" value="Squalene_epoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040125">
        <property type="entry name" value="Squalene_monox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835:SF0">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08491">
        <property type="entry name" value="SE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="599"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="626"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="678"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene epoxidase" evidence="11">
        <location>
            <begin position="42"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS22372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="706" mass="78733" checksum="DA070B1C96A86578" modified="2011-10-19" version="1">MGTENATLIEATAVEMIRDGETGAVIGAKCSRSGGEPEEFYASLTILADGSTSNFRSQFTRYRPVSRSRFWGLELVNAELPIPRYAYGILGIGGPILMYRLSNRETRVLIDIPDDIYGSLGSPDSVRDYIREHIVPSFPEPVRANLEEAVRESRLRSMPNASMPSSTNTTPGLVLLGDVANMRHPLTGSGMTVALKDAVLLAEMLSPANVPSLNDTGSVLAQLKRYHWKRKSHSASLNMLAQALYLLFVGKDNIVGIMQRGFVRYVQGGEKNFAEPAWIMGGIVDSPLVLFRHFFKIAFYSIGLHFQESGVLGFPAALVRSGGNGNNGGGRSAVADATQCFLFVCVWTILHHNLQAKDDGYWTIFFRKLRWAVLAVAAPEMLTLFAVMQWNATNISVRKMRDLGFKNWTRVHAFYANAGGFFLKAPDFPAFPLNATSLHYLLQQKRITLPNLSRDNIWDRSKADHFAKFVAFLQAGWTILHIVARRIQNLTVTPLEVFTAAFIVPSFATAWAWADKPQNVAEPTVLEVDWTIADLLLSAGDAAKEPYVDTPLDFVEKPVWAGWKRRRSLFHFGGLNRRPSPRIPNDYSPPPPTGTEATIVWVVSVIHAGLHVLCWNFPFPTRFESLAWRSASVILLVCMAIGGLVPVLSTREWFDFEFSMIWIWVKEARKMTCTVDDVFTACGLIGSALVIFNYVRLSSLCYHRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0S321</accession>
    <name>G0S321_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="6">5.3.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phosphohexomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Phosphomannose isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0019350</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="6"/>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692423.1">
        <property type="nucleotide sequence ID" value="XM_006692360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S321"/>
    <dbReference type="STRING" id="759272.G0S321"/>
    <dbReference type="GeneID" id="18255973"/>
    <dbReference type="KEGG" id="cthr:CTHT_0019350"/>
    <dbReference type="eggNOG" id="KOG2084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2757">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_332879_0_0_1"/>
    <dbReference type="OMA" id="FECHCEL"/>
    <dbReference type="OrthoDB" id="6605218at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07011">
        <property type="entry name" value="cupin_PMI_type_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.441.10">
        <property type="entry name" value="Phosphomannose Isomerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016305">
        <property type="entry name" value="Mannose-6-P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046457">
        <property type="entry name" value="PMI_typeI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00218">
        <property type="entry name" value="manA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309:SF4">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20511">
        <property type="entry name" value="PMI_typeI_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00714">
        <property type="entry name" value="MAN6PISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SET" evidence="14">
        <location>
            <begin position="520"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="805"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="805"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS22404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="859" mass="95423" checksum="ADCE4E535FC41AC5" modified="2011-10-19" version="1">MTATPSNYVTCTMAARIFQLVGACNNYPWGKHGNESLAARLCSKTDRNFTISSDTPYSELWFGDYHTNPARVLTTGEPLNHVLSENKDTLLGRKVITQLGSQLPFLPKILSIAKALPLQLHPDKRISSLLHSKYPVHFQDPNHKPEIAIALSRFELFAGWKPLSHITELFSLPALRPFVPVTHDPGRPFTEGTLRSLTRNILTAPGEDLRFALSQLKHAPKSLLGESAYIRTLLPRLEEQYSPTDPGILVSLTCLNYFTLSPGEAVFIPANGIHAYLSGDVLECMARSDNVLNAGFCPEEERDDVDIFVNALLIEGQGPGDIKLKVKEKATEGEGARVVRYRPPGVEEFEVWRIELGENAEGEMEGGDGPGIMIVVRGAGKMEAEGKLVDVEEGAIWVQHILSALLFTPFTLSSSIQPSQCARGGAPPHLSFPTSHTVPAPNNPASWLPWTHPPRCIESSETPYCVYTAAHLPPYSRHGISVLTTPELASSSALNPFHSLHDLNDDPAHFFAPEKLEYPPPYEVREVPGKGLGLVATRKIPKGKAIMIDYASVLANVEYPADVMREDVQDLLELAVDQLPEPKSVRGLAIQGKEGVGFVEDVMLTNSFGVAVGGREVMALFTNLARINHNCRPNAFIHFSDTTLAMTLWSAREIQPGEEITITYSPAGRTSKERQRMLKSTWGFECHCELCTSPPEVVNASDANLLEIRRLQNEVLKLAQNGSFQEAVQGAEKMFDLIAVEQLTEHMADLYETAGRLYYHAGNLEKALEYSLKVKHEIVGWGVPGPFGRDKLKMMDNVIKRIERELGEQKKAEEEERKKKEKEVKGEKNEETKEEKLRGEEPKEEKEPQQKTQDNQEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3V0</accession>
    <name>G0S3V0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0038970</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
            <location evidence="1 6">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS22012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694308.1">
        <property type="nucleotide sequence ID" value="XM_006694245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3V0"/>
    <dbReference type="STRING" id="759272.G0S3V0"/>
    <dbReference type="GeneID" id="18257935"/>
    <dbReference type="KEGG" id="cthr:CTHT_0038970"/>
    <dbReference type="eggNOG" id="KOG2065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005595_0_0_1"/>
    <dbReference type="OMA" id="QLSMWLL"/>
    <dbReference type="OrthoDB" id="78652at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF27">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="9">
        <location>
            <begin position="2"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="8">
        <location>
            <begin position="307"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="561"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="565"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="578"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS22012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="768" mass="83978" checksum="75FC878C867F1A88" modified="2011-10-19" version="1">MLHEILLSLSGHPSPLLSPSPTDTQAQHPQSPLSCLTPPERSLLTSLARLSTLHISLQTSSAQLASSHPSLIARTVASAIDTVHLSAFRQTVLEVERKLLTGDAGLVGGYGIVPLTAVVGEFEGWGRRLEWLGEVVGYLEKGGPNGGWAMGVGVMNWLRGQMVTGFGDVQEAAGRLVSVAEEAWLKLVAAWVLYGRVPSAGEGDFFVRRGEEGDEFMTDPTLLPSFVTPHTASSILFIGRSLNQLRAKAVADHTLRGTDHLSSQLTKLSSLQHPLDSATFSAAIADIRLHLSRHTLQRLLPLPRVLDLLQLLRDFFLLRRGDFAIALTQTAGEKMASRWRRADNLAIYENRRESTGLGGVTLKEGEIAAVLSKTWAAMGAMQGSQAYTDEDESVERARGLLKLSIVKNRPGTPASFTGGDGGILAAIASTPFKNLLFSVPVVLTMDVPSPLDLFLTPADLQVYSAVNAYLLSLRRAHIKLTELWKISALRRHHPAPPGPSDRNRGRTRLLRGRFDGRERVLRNVWATASAAIFFLGEVEAYLQTEVVDVLEEGFVRWVRGEETTSRPGTRATSPSLSRRGDPPEDGHDHDQDPTKFRDPQSLQTFHHLYLTRLTHSLLLTSPLFTDALYETLVHIDRLVALITRLHAVWAAADLEEDAGVVDAFVDLVKEERDVRGELDEVQKEVRRGVEGVVGVLRDMEGRFGAEGDEGEKEGGEDVVMRERGEYVPGRVGGVERLVMKLDFGSWFQGAGTGNGIGGKGVGEDEEMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G0S438</accession>
    <name>G0S438_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 16">Aurora kinase</fullName>
            <ecNumber evidence="2 16">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CTHT_0022440</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Forms a ternary complex with ATG13 and ATG17.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2 16"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692710.1">
        <property type="nucleotide sequence ID" value="XM_006692647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S438"/>
    <dbReference type="STRING" id="759272.G0S438"/>
    <dbReference type="GeneID" id="18256282"/>
    <dbReference type="KEGG" id="cthr:CTHT_0022440"/>
    <dbReference type="eggNOG" id="KOG0580">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_6_1"/>
    <dbReference type="OMA" id="AKVYRCT"/>
    <dbReference type="OrthoDB" id="377346at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045143">
        <property type="term" value="P:homologous chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044779">
        <property type="term" value="P:meiotic spindle checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090266">
        <property type="term" value="P:regulation of mitotic cell cycle spindle assembly checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902115">
        <property type="term" value="P:regulation of organelle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072479">
        <property type="term" value="P:response to mitotic cell cycle spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14007">
        <property type="entry name" value="STKc_Aurora"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000235">
        <property type="entry name" value="Serine/threonine-protein kinase ark1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="196"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="63"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="106"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 14">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="275"/>
            <end position="277"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="324"/>
            <end position="325"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="13">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGS20414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="468" mass="53460" checksum="103F1559A77C9272" modified="2011-10-19" version="1">MTTRGLESRFERLAVTDENDPGENMRLYQKTKTVEPSTTRYSTQPMKPKNLFKIALQSQNANSANTLKTTVTLPSQAAQRSHPMTPTNPPSPRKERDARKEREKPSGSASASSTSATISSAKSRPSPPTSTKSTSSTSTYSSKHDYYDAEQQVNEQPDEETEESQKEEQQQEEETAVVPAPQIEKPVVKNFHLGMFEIGRPLGKGKFGRVYLARERTSGFICALKVLYKSELQQGSGVEKQVRREIEIQSNLRHPNILKLYGHFHDSKRIFLILEYAGKGELYKHLRREGRFPEWKAAQYIAQMASALKYLHRKHVIHRDIKPENILVGIHGEIKISDFGWSVHAPNNRRKTLCGTLDYLPPEMIRSGSKENWYNEKVDLWSLGVLTYEFLVGEAPFEDTPIMTQRRIAKADMTIPQWVSKEAQDLIKRLLVLDPEKRLSLDEVQNHPWIIKHCVKGERAANREKPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0S458</accession>
    <name>G0S458_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0030790</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693528.1">
        <property type="nucleotide sequence ID" value="XM_006693465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S458"/>
    <dbReference type="STRING" id="759272.G0S458"/>
    <dbReference type="GeneID" id="18257117"/>
    <dbReference type="KEGG" id="cthr:CTHT_0030790"/>
    <dbReference type="eggNOG" id="KOG0748">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023075_2_0_1"/>
    <dbReference type="OMA" id="IGNACDY"/>
    <dbReference type="OrthoDB" id="529367at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF52">
        <property type="entry name" value="ADIPONECTIN RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS21232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="354" mass="39081" checksum="E1EDAE340F3FA9E3" modified="2011-10-19" version="1">MPDNDPNGAAGNCMPKVAATLAPPEPASSSSGSTSASTKVRQRRPSFTESATAAAESLLHTAEATVEATLHQIGNLLWSWDDLPAWRRDNHFIRSGYRPTSYSVRACLASLGYLHNESVNIWTHLLGSAAFLLGGLLLYALVAPRYASASDSDVLVFACFLGGAFVCLGMSATFHTLSNHSPEVAMWGNKLDYTGIVFLIVGSYVPALYYGFFCHEYLMTFYLATIALLGFGCLVVSWFEHFRTPEWRVYRTLMFVGLGLSGVVPIFHAFEFYSYSELNERMGLNWVILQGALYIFGAFLYAVRWPECKYPGTFDIWGSSHQIFHVFVILAAAAHLNGMAKAFDYHHSVLGLQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0S535</accession>
    <name>G0S535_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">intramembrane prenyl-peptidase Rce1</fullName>
            <ecNumber evidence="10">3.4.26.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0023940</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic sidechains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.26.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase U48 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.26.1" evidence="10"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692856.1">
        <property type="nucleotide sequence ID" value="XM_006692793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S535"/>
    <dbReference type="STRING" id="759272.G0S535"/>
    <dbReference type="MEROPS" id="G05.002"/>
    <dbReference type="GeneID" id="18256432"/>
    <dbReference type="KEGG" id="cthr:CTHT_0023940"/>
    <dbReference type="eggNOG" id="KOG4130">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049909_1_1_1"/>
    <dbReference type="OMA" id="HSFCNWC"/>
    <dbReference type="OrthoDB" id="271604at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039731">
        <property type="entry name" value="Rce1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1/LyrA-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046:SF0">
        <property type="entry name" value="CAAX PRENYL PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046">
        <property type="entry name" value="PROTEASE U48 CAAX PRENYL PROTEASE RCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 2/Lysostaphin resistance protein A-like" evidence="12">
        <location>
            <begin position="168"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS20560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="366" mass="41021" checksum="942F0392624664AB" modified="2011-10-19" version="1">MPALGEVFSKINPWHKDNPPPPRLTTRTTVLLLILYALSYFIPFYLSSSTRPSTTHSRDAPSVIRARIRSVTFTCFTCAAATYIILLRTYVPSSEDGDGAVLSGPHRQALHLLGVWPVGLWDGLKALGLTMVLYLGPLYAYLVVEGGWRDWILRGCAPAREVLFGWEWTSWRNIVAGPITEELLFRSSSIPLTLRSPLTPSQIIFFTPIIFGLSHVHHFYEFRLSHPGVSFLPALLRSLFQFAYTTLFGAYATFLFLRTGSFLGVCAVHAFCNCMGLPQLWGRVEPEDDDEEGLERAVPVMAGGDAGQQHSSGNRGQKRKRLSILWTIIYYVLLVTGAVLWWRNLWSWTEGSNALVPKQAFKKAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0S573</accession>
    <name>G0S573_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small ribosomal subunit protein uS4m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0032490</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693688.1">
        <property type="nucleotide sequence ID" value="XM_006693625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S573"/>
    <dbReference type="STRING" id="759272.G0S573"/>
    <dbReference type="GeneID" id="18257287"/>
    <dbReference type="KEGG" id="cthr:CTHT_0032490"/>
    <dbReference type="eggNOG" id="ENOG502QTS9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026386_1_0_1"/>
    <dbReference type="OMA" id="GDMFQVE"/>
    <dbReference type="OrthoDB" id="3356781at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000025">
        <property type="entry name" value="30S ribosomal subunit S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="12">
        <location>
            <begin position="130"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="202"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="311"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="341"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS21392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="481" mass="54807" checksum="F564D5B0D5195885" modified="2011-10-19" version="1">MKQRRLMRFHGLRRPRVRQTWNKYNLYNLARLRTPSLNSKTFFQQKWIAKSLTRGYHGEHIKEHQWERMFSRRLLSAVNMDPRYMARYDGSEQGAGRGSGLKGMTDKIKNPGNLNLPTPYMQMTFAPQERRLDIAIFRACFASSARQARQFVLHGAVTVNGKRMRHPQYLLNPGDMFQVNIERVMTATGKPKPYHQAREAEQLMGGSKSAEGEEGEGEEAESKEEEIPAEAESTPEDREARRKEHLQKLADLKKRTKAIIEDKATAKQKKQLRGFIKELNKAIQQAASKKDLREASELQRVEAGLAELFDTLSLTPAERHAKEREKAAAEAKEDSSEEVTESASTEPAAAESSPAPSSELVTPSTTSEPAQQSSSPSQTTSKSTADEPLDLSSLEKKILARLLREERENPYDPTKPYKTPWEPKPWMSPFVFIPRYLEVNQRICAAVYLRHPVARPGRSEVPSPFSNTLAQLAFNWYLKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5A8</accession>
    <name>G0S5A8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Polyprenal reductase</fullName>
            <ecNumber evidence="5">1.3.1.94</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0024150</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Plays a key role in early steps of protein N-linked glycosylation by being involved in the conversion of polyprenol into dolichol. Acts as a polyprenal reductase that mediates the reduction of polyprenal into dolichal in a NADP-dependent mechanism. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a di-trans,poly-cis-dolichal + NADP(+) = a di-trans,poly-cis-polyprenal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:80727"/>
            <dbReference type="Rhea" id="RHEA-COMP:19536"/>
            <dbReference type="Rhea" id="RHEA-COMP:19537"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:231623"/>
            <dbReference type="ChEBI" id="CHEBI:231637"/>
            <dbReference type="EC" id="1.3.1.94"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="5">
            <dbReference type="Rhea" id="RHEA:80729"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the steroid 5-alpha reductase family. Polyprenal reductase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.94" evidence="5"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692877.1">
        <property type="nucleotide sequence ID" value="XM_006692814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5A8"/>
    <dbReference type="STRING" id="759272.G0S5A8"/>
    <dbReference type="GeneID" id="18256453"/>
    <dbReference type="KEGG" id="cthr:CTHT_0024150"/>
    <dbReference type="eggNOG" id="KOG1640">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044409_0_1_1"/>
    <dbReference type="OMA" id="RFYETNF"/>
    <dbReference type="OrthoDB" id="541710at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003865">
        <property type="term" value="F:3-oxo-5-alpha-steroid 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160198">
        <property type="term" value="F:polyprenal reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102389">
        <property type="term" value="F:polyprenol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016095">
        <property type="term" value="P:polyprenol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039698">
        <property type="entry name" value="Dfg10/SRD5A3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14624">
        <property type="entry name" value="DFG10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14624:SF0">
        <property type="entry name" value="POLYPRENOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="6">
        <location>
            <begin position="240"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS20581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="350" mass="38515" checksum="C9996AC97E94457D" modified="2011-10-19" version="1">MDFPTDPVVCTSTCSQQSSPYLATLTNILSTLSPAQWCQSFFLFYTAGVTAVALLPKDVKALVVEYGARKSSATAQGEGTQAQEKQHKDRKTARDKLITLIAQVTTLTQVPHAWFAWFYTLSLACSAFWLGQYLYDGRLLHIIATAQFSAAPNGPSVTLVQTALAWTMMLLQAARRAYEDAAIMKPSAKSTMWVVHLVLGLGFYAGMGVAVWVEGSVAILSIESKTKVFDDANAEALIKIALTTPAFLYAWINQHRCHRHLAGLEKYSLPSEGLFCRFVCAHYTCECLLYLAMAVGAAPQGQWINRTLLCALLFVVVNLGVTAAGTRRWYAQKFGAEAVRGKWNMIPFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5E8</accession>
    <name>G0S5E8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome P450 monooxygenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0024550</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <location>
            <begin position="406"/>
            <end position="427"/>
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            <position position="345"/>
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    <sequence length="455" mass="51158" checksum="984732F18870FC34" modified="2011-10-19" version="1">MFTTLEKDEHARRRRLIADRYANTNVLRPQSLGGIAQNATNFVRRCFESVGGSLDIYPGLHAYAFDCITHHLFDPYDTKSLQDVKDEEVMREVTFDDSLQNRLLKHYHPTIHRLLGNALRTLFNAKPRETPLADAFVLDKTTSPSLSPSPSPFTLLHRLRQSLDKSEKADYDDSGSAQGTFIPDSLDIAAECLDHMAAGIDTTGDALCFLMWELSQPRSRHVQRKLQQELLAAKSNGVTDNKLAQLPYLEAVIMEGLRCWPAIPMSLPRVVPWDEKGGKEIDGWWVPSGTVVSCQAYSVHRLGIDSKGEWFPEEAEGFRPERWLGGEAEEWKKRFFAFATGGRGCIGKHLALAEMRLLLKEVYSRFSTFPDDSMTQEDMDMSDQLISSRPRGQRCLLRFVPLEDLAGKHHGSPTPGRQQMAAEEPESTVWRVNSTCKGIANSYVETLDNESLGAA</sequence>
</entry>
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        <name evidence="13" type="ORF">CTHT_0024640</name>
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        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
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        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
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            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2016" name="Cell" volume="166" first="380" last="393">
            <title>Architecture of the 90S Pre-ribosome: A Structural View on the Birth of the Eukaryotic Ribosome.</title>
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                <person name="Kornprobst M."/>
                <person name="Turk M."/>
                <person name="Kellner N."/>
                <person name="Cheng J."/>
                <person name="Flemming D."/>
                <person name="Kos-Braun I."/>
                <person name="Kos M."/>
                <person name="Thoms M."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
            </authorList>
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            <dbReference type="DOI" id="10.1016/j.cell.2016.06.014"/>
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        <scope>STRUCTURE BY ELECTRON MICROSCOPY (7.30 ANGSTROMS)</scope>
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    <reference evidence="17 19" key="3">
        <citation type="journal article" date="2017" name="Elife" volume="6" first="e22086" last="e22086">
            <title>Molecular architecture of the 90S small subunit pre-ribosome.</title>
            <authorList>
                <person name="Sun Q."/>
                <person name="Zhu X."/>
                <person name="Qi J."/>
                <person name="An W."/>
                <person name="Lan P."/>
                <person name="Tan D."/>
                <person name="Chen R."/>
                <person name="Wang B."/>
                <person name="Zheng S."/>
                <person name="Zhang C."/>
                <person name="Chen X."/>
                <person name="Zhang W."/>
                <person name="Chen J."/>
                <person name="Dong M.Q."/>
                <person name="Ye K."/>
            </authorList>
            <dbReference type="PubMed" id="28244370"/>
            <dbReference type="DOI" id="10.7554/elife.22086"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.64 ANGSTROMS) OF 1-471</scope>
    </reference>
    <reference evidence="16" key="4">
        <citation type="journal article" date="2017" name="Nat. Struct. Mol. Biol." volume="24" first="954" last="964">
            <title>3.2-A-resolution structure of the 90S preribosome before A1 pre-rRNA cleavage.</title>
            <authorList>
                <person name="Cheng J."/>
                <person name="Kellner N."/>
                <person name="Berninghausen O."/>
                <person name="Hurt E."/>
                <person name="Beckmann R."/>
            </authorList>
            <dbReference type="PubMed" id="28967883"/>
            <dbReference type="DOI" id="10.1038/nsmb.3476"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.20 ANGSTROMS)</scope>
    </reference>
    <reference evidence="18" key="5">
        <citation type="submission" date="2017-01" db="PDB data bank">
            <title>Crystal structure of Chaetomium thermophilum Utp10 N-terminal domain.</title>
            <authorList>
                <person name="Chen R."/>
                <person name="Zhu X."/>
                <person name="Ye K."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 1-471</scope>
    </reference>
    <reference evidence="20 21 22" key="6">
        <citation type="journal article" date="2019" name="Mol. Cell" volume="75" first="1256" last="1269.e7">
            <title>Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration.</title>
            <authorList>
                <person name="Cheng J."/>
                <person name="Bassler J."/>
                <person name="Fischer P."/>
                <person name="Lau B."/>
                <person name="Kellner N."/>
                <person name="Kunze R."/>
                <person name="Griesel S."/>
                <person name="Kallas M."/>
                <person name="Berninghausen O."/>
                <person name="Strauss D."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="31378463"/>
            <dbReference type="DOI" id="10.1016/j.molcel.2019.06.032"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.50 ANGSTROMS)</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the HEATR1/UTP10 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EGS20630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="resolution" value="7.30 A"/>
        <property type="chains" value="G=1-1802"/>
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        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="G=1-1802"/>
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        <property type="chains" value="A/B=472-872"/>
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        <property type="resolution" value="7.00 A"/>
        <property type="chains" value="UJ=1-1802"/>
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        <property type="resolution" value="3.50 A"/>
        <property type="chains" value="UJ=1-1802"/>
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        <property type="resolution" value="4.00 A"/>
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        <property type="resolution" value="7.10 A"/>
        <property type="chains" value="UJ=1-1802"/>
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        <property type="resolution" value="4.70 A"/>
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        <property type="resolution" value="4.40 A"/>
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    <dbReference type="EMDB" id="EMD-10056"/>
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    <dbReference type="SMR" id="G0S5L1"/>
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    <dbReference type="eggNOG" id="KOG1837">
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    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="15 16 17" id="KW-0002">3D-structure</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6 10" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="BP28 C-terminal" evidence="12">
        <location>
            <begin position="1512"/>
            <end position="1665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="884"/>
            <end position="906"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00025076"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU367065"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS20630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="5JPQ"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="5OQL"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PDB" id="5WY3"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PDB" id="5WY4"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="19">
        <source>
            <dbReference type="PDB" id="5WYL"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PDB" id="6RXT"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="21">
        <source>
            <dbReference type="PDB" id="6RXU"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="22">
        <source>
            <dbReference type="PDB" id="6RXV"/>
        </source>
    </evidence>
    <sequence length="1802" mass="198279" checksum="E29B3E8BEE8EE5C9" modified="2011-10-19" version="1">MASSLAQQLAQIAANSRSSFNVKALKASHSKSLIWEPRVAVSQTFAEIYSQCYEGFKELCHLDSRFVPFDATLFSAQSQEVDRTQMTAEENAALDKRVDSFLHLVGSRLRLMPAIKAVEWLIRRFRIHEFNTGTLLATFLPYHTIPAFVTLLSILPVQRIPIEYRFLDPYIKSLTPPPRAAIVQQATNRPDLLSAISRYTLDSCRAKQEYPGLISFWGGIMAEAVNGMIDKMRSGRRAIQLENDHLLLQQIGPVLSEAMVMKDVPGIQIASYMVVAILAAKGSLNDNILTAFMEQLVHGWTVDTLRPGLVCLTMLAQHRSAKQLSGRVAKAVIKVPDLVSSLRDISKEHQVDKLANGLVLAFVDRLAKKGDIRTLPVINSLLLSELLQEKQAKVAYKALLLAAHKIDDNVDADGNIRKQVGSALVRLSQAEGDVGDAIRTAIQEVDFNIEELELKLGAAIRPKLAIEEAPEPSDEAMTVRPVDQRPSLDSTFERLSKLQPTATSCLAKDSESLFNDLCSVFLSAAVSESDLERFDATPVLSRPKAPSNSFYLSFYLRVWCGPYPTLAKVAALERVKTRLKEGDCVDKDFQAIFPYCIAALSDPAKKVRRAAADLVAVLGSAYKSLEKSQQLWAAKDLYGKTGTTSPLDKDALKALIRSVLIPCLEESVLHEDHVVAALVGALESSKDSENKNADKRHLSHSARLSIFKFLCGHVVETPLLAVKLRLLRSLNQIRRISGTTRTDLLLPLLRWWAGLSANEAAELAAQESVDVPAIDDAVVDVVVPNHAAGLEAFFQLVKEAIRPGLLQAIFARIAKMWPSMKSDTKYSTAKTLFELTQDPKLNAEQSDVITEAVEVLRKVDLTTDILHYFIDSLQDEVRLATEGPANKRRRVSTTEPGRGVGTQSSPELQAALSKTTFVLELVQESTPANHPELLPSLFTTLSDLHHLSAIVGSELGYLQNLVLSSLLAMMPTYKDNKDLTIDASVGHGDVLATCIQKSTSPAVINSALLLVASLARTAPDVVLQSVMPIFTFMGSSVLKQADDYSAHVVNQTIKEVIPPLIETFRKRGRNVVASAKDLLASFVTAYEHIPSHRKHNLFISLIQNLGPDDFLFAILAMFVDRYGATDNMITFMTQLISSFTVETQLQTLLKFLDLVGDLFKSKPTLSNVLLGGGSGLNGEQDIQKAATKQLNLLPHLLSNRRLKREIMQLAERDDMEAGKIRELYAALLEGILTVASTVKTKKTLHSRCGDALSNLLNLLSIAEFIKSVEALLDRPNIGLRQKVLRALELRVDSESSVDPKSREALLAFLPQLTAVIRESDDMNYKHTAVICVDKISEKYGKKDLDAVAAAATTIAGDYCLGQPSQSLRVMALLCLASLVDVLQDGIVPVLPVAIPKALSYLEQSVAEGGRDVELHNAAYAFMTALAQHIPYMITGNYLDRLLACSNASAAANLDDEANANRMQCLQFLAKLVDARVLYTGLHQNWASAAKFGFSAISEYLQILGIALDKHSKTVVVKNVSSLSSIFLSAMDLRRTVAAGDIASQISAMELDEIETKTHEDALKMVYKLNDAAFRPIFSKFVEWATTGLPKSDVTGRTYRLYVVFGFLDAFFGSLKSIVTGYASYIVDASVKALKAVDFAVPEERNLWKRVLCTLAKCFEHDQDGFWQAPAHFGAVAPVLVEQFLRAEGQVTATNVNDVIQDVVPAVVELAAAVESQEHYKEINTALLKHLRNGSPGVRLAVVKCQQAITAKLGEDWLHLLPEMLPYISELQDDDDEVVERENRRWIVGIEEKLGESLDSMLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5N7</accession>
    <name>G0S5N7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0024920</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692952.1">
        <property type="nucleotide sequence ID" value="XM_006692889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5N7"/>
    <dbReference type="STRING" id="759272.G0S5N7"/>
    <dbReference type="GeneID" id="18256530"/>
    <dbReference type="KEGG" id="cthr:CTHT_0024920"/>
    <dbReference type="eggNOG" id="ENOG502QUE5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014054_0_0_1"/>
    <dbReference type="OMA" id="MEIDFTA"/>
    <dbReference type="OrthoDB" id="5374328at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018287">
        <property type="entry name" value="Hap4_TF_heteromerisation"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF7">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10297">
        <property type="entry name" value="Hap4_Hap_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="4">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="31"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="193"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="377"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="223"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS20656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="638" mass="66375" checksum="2153BC0F737F5A7B" modified="2011-10-19" version="1">MAVSVSAGPSTGSNADNAAASPINASSITAAVSHNSPASVSSPASVASPSSVSTSTTSCSTAPPPIAIRPNPTPKPLSIKTPNPATHMSSNGSVPQGGLSMTTKEWVVPPRPKPGRKPATDTPPTKRKAQNRAAQRAFRERRAARVGELEEQLESEKAAHEKAVRELQERISMLELETQTLQSRCRWLESALERERQSRNGQATTSWDSPSMEPPRHTSFFSPQTQPQPQPSQLAPAAVAAPGMRPLKPAPLKSSIISPVTIEQPKPLPQPFSITQIVSPLEEVISPVDLTCGKCGTNGSCACAEAVMATTDIAIGCGKCTLGSRCQCLEETLGVSVPATSSDLKRPGSPPPTSPEEKRQRSDAGIVMETDFTAIFSSQSNKDPAPSTFSSSTQPLMTSEPPRDPCGFCKEGTYCVCADSMITSEPQPLIAPTQTRTPPPSENDVAPTPMEVTATGAIKLPNLRNGQRQHRTAAKPQQPAASATLSGCGPNGPGTCAQCLADPKSGLFCRSLAANFEKNNPGASLAGGGGGCCGGGGPGGCCKSGNSNSDSQTSTSGFGLSLSCAEAYKTLASHRHFDEAADDIGSWLPKLKALPIPRPSEPGAGSGQGLTRRAPIEVEAASIMSVLKDFDVRFGRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5Q3</accession>
    <name>G0S5Q3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Catechol 1,2-dioxygenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0025080</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692968.1">
        <property type="nucleotide sequence ID" value="XM_006692905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5Q3"/>
    <dbReference type="STRING" id="759272.G0S5Q3"/>
    <dbReference type="GeneID" id="18256546"/>
    <dbReference type="KEGG" id="cthr:CTHT_0025080"/>
    <dbReference type="eggNOG" id="ENOG502QU2V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046727_1_1_1"/>
    <dbReference type="OMA" id="APNGMYE"/>
    <dbReference type="OrthoDB" id="5238185at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018576">
        <property type="term" value="F:catechol 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009712">
        <property type="term" value="P:catechol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03461">
        <property type="entry name" value="1_2-HQD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039390">
        <property type="entry name" value="1_2-HQD/HQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007535">
        <property type="entry name" value="Catechol_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050770">
        <property type="entry name" value="Intradiol_RC_Dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711:SF7">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04444">
        <property type="entry name" value="Dioxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00083">
        <property type="entry name" value="INTRADIOL_DIOXYGENAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="7">
        <location>
            <begin position="164"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS20672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="313" mass="34853" checksum="A69A20CACE6C57D0" modified="2011-10-19" version="1">MGQMIPEPAPKLSMEARLNGLSKMSQTSSNFTERVIAATGPNAHPRLKEIIPSLVRHLHDFAREVKLTVGEWEAAVEFLNECGKMSNDRRNETQLLCDILGLESLVDDITSKLLASSASETPSAILGPFYRHNAPLLPNGSSIIQDLDPSVPWYTQAVADSAHVTGRVLSSSGEPIKGAIVDVWHAAPNGLYEQQDEAQPDMNFRGRFMTDAEGRYSFYALRPVSYPIPDDGPSGRLLKLLDRHPYRPGHIHFIVSAPGFRTLTTQLYDDRDHYVTNDAVFAVKDELIVKFVPKEGDPKALWLLEYDFVLGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5Y2</accession>
    <name>G0S5Y2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Steroid 5-alpha reductase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0025340</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692994.1">
        <property type="nucleotide sequence ID" value="XM_006692931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5Y2"/>
    <dbReference type="GeneID" id="18256572"/>
    <dbReference type="KEGG" id="cthr:CTHT_0025340"/>
    <dbReference type="eggNOG" id="KOG4650">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043418_0_1_1"/>
    <dbReference type="OMA" id="WFTEYIT"/>
    <dbReference type="OrthoDB" id="201504at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF23">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="28340" checksum="1EE508BDE788CC34" modified="2011-10-19" version="1">MRIHMIRLTYNYWRKGGYSVGHEDYRWAIIRGKISKLAFHIFNLTFISFMQSILLFLISSPVYVLLLASTIEPEVSTADVAALIIELVLILIESIADQQQWNYQSAKKKYKDSGEVPRGFRKTDLDRGFITSGLWGYSRHPNFAAEQTIWFVLYQWSCWAARTLFSWAGAGATFLIMLFQGSTWFTEYITSGKYPEYYDYQQAVGMFVPKSIFSYEKPVRRPKIIRTSELAQKKSQVQKQKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5Z5</accession>
    <name>G0S5Z5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2'-phosphotransferase</fullName>
            <ecNumber evidence="3">2.7.1.160</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0025470</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2'-phospho-[ligated tRNA] + NAD(+) = mature tRNA + ADP-alpha-D-ribose 1'',2''-cyclic phosphate + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:23324"/>
            <dbReference type="Rhea" id="RHEA-COMP:11106"/>
            <dbReference type="Rhea" id="RHEA-COMP:11107"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:76596"/>
            <dbReference type="ChEBI" id="CHEBI:82883"/>
            <dbReference type="ChEBI" id="CHEBI:85027"/>
            <dbReference type="EC" id="2.7.1.160"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KptA/TPT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.160" evidence="3"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693007.1">
        <property type="nucleotide sequence ID" value="XM_006692944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5Z5"/>
    <dbReference type="STRING" id="759272.G0S5Z5"/>
    <dbReference type="GeneID" id="18256585"/>
    <dbReference type="KEGG" id="cthr:CTHT_0025470"/>
    <dbReference type="eggNOG" id="KOG2278">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052998_0_1_1"/>
    <dbReference type="OMA" id="HATWPKI"/>
    <dbReference type="OrthoDB" id="419694at2759"/>
    <dbReference type="BRENDA" id="2.7.1.160">
        <property type="organism ID" value="1279"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000215">
        <property type="term" value="F:tRNA 2'-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.970">
        <property type="entry name" value="RNA 2'-phosphotransferase, Tpt1/KptA family, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042081">
        <property type="entry name" value="RNA_2'-PTrans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042080">
        <property type="entry name" value="RNA_2'-PTrans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684">
        <property type="entry name" value="PUTATIVE PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684:SF2">
        <property type="entry name" value="TRNA 2'-PHOSPHOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS20711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="322" mass="34830" checksum="5E48356EA6783B71" modified="2011-10-19" version="1">MDYDYDTPDASDALAERFEQAMSTTGRGQRRGPAGGRKAGSGGSGGSGGPGGNGRSKRDVVLSKALSRLLRHQADAAGITLDKEGFAPLDKVFLYGPIRSLKPTFSEIVDCVKSSDKQRFAMKPNPATNPSLDESSTDPSHWLIRANQGHSIKLDSEHLLRPIVPNPAPDSNELPIPPVVVHGTYFAFWPQIESSGGLKRMNRNHVHFSTGLPEDNGKEVISGMRSDAEVLVYVDVERSIREGGLKWWMSDNGVVLTEGNEEGMVEKKFFKEVVGRRQNVGVLWKDGEKVADLPEGLVIKQPFGKAGKGAKGSRGGGRGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G0S665</accession>
    <name>G0S665_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">acetyl-CoA C-acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CTHT_0034340</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="5"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693869.1">
        <property type="nucleotide sequence ID" value="XM_006693806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S665"/>
    <dbReference type="STRING" id="759272.G0S665"/>
    <dbReference type="GeneID" id="18257472"/>
    <dbReference type="KEGG" id="cthr:CTHT_0034340"/>
    <dbReference type="eggNOG" id="KOG1390">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031026_0_1_1"/>
    <dbReference type="OMA" id="SMGTFGE"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000007">
        <property type="entry name" value="acetyl-CoA acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF156">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0630">Potassium</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="14">
        <location>
            <begin position="37"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="15">
        <location>
            <begin position="305"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="12">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGS21573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="428" mass="44855" checksum="C1F6BF80F7ABDC1E" modified="2011-10-19" version="1">MVAHLRTALRVSPQLRAGSARLFSSQTCLRQEIRDAYILGAARTPTAKFNGSFVSVSGPELGAVAIKAALEKSKVPVEKITDVYMGNVLQASIGQSPARQAVIFAGLPRTVEAVTINKVCASGLKAVALAAQNIQLGLSDAQIAGGFENMSRVPYYVPRASGLPPFGHVKMEDGLIKDGLTDVYDQIHMGNCAENTVKKFGITREEQDQYAIQSYERAQAAWKAGAFSDEIAPVTVKGRKGDVVVSEDEGYLDVKPEKVPTLKPAFVRDGTGTVTAANSSTLNDGASALVLGSKEIAQQYGAGSRVLARICSSADAAVDPIDFPIAPSKAVPIALERAGITKDQVAVWEFNEAFAAVIKANEKILGLEGARVNPLGGAISLGHALGSSGSRILVTLLHQLKPGEYGVAAICNGGGAATAMVVQRIESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6B3</accession>
    <name>G0S6B3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative iron transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0026140</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693073.1">
        <property type="nucleotide sequence ID" value="XM_006693010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6B3"/>
    <dbReference type="GeneID" id="18256652"/>
    <dbReference type="KEGG" id="cthr:CTHT_0026140"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012970_2_0_1"/>
    <dbReference type="OMA" id="PWKGKGL"/>
    <dbReference type="OrthoDB" id="4088837at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015343">
        <property type="term" value="F:siderophore-iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000197">
        <property type="entry name" value="Siderophore iron transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF87">
        <property type="entry name" value="SIDEROPHORE IRON TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="435"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="472"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="514"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="591"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="76"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS20777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="644" mass="69180" checksum="B97659B411E41EBC" modified="2011-10-19" version="1">MRAAGHDDDAREPLIFAGGRNGDGDDNSDCSEYGAVAYSSARGPRENDGGLSDARSNVQDGVRRIDALSRAWSQWGLAVAYLSIFFMAFTLSLEGQVTYSLAAFAVSSFHNHSLLSTVYVVQGVVNAVIKPPMAKVADVFGRLEAFCISIILCVLGYVQMALSHNVQTYASAQIFYSAGSTGLQILQQVFIADTSSFLNRGLLSSIPDSPFLVTVWIGPAIAAAILAHASWRWGYAIWAFILPVAFMPLALSLFLNTRKAQKLGLLPKKRHPNSQDDEESARAVAKRLFDDLDIGGTLLLSGGLALILIPLTLVSHSQSGWHDPLLVAMIVMGLILLILFPLWESRPNLAPHPLLPFPLLKSRTFCAGCFLAFSWFAVFYIAVQPYLYSYLLVALNLPVSIAGPITQIFSFASTIAALVASLIIRRLGEPRPRPFIIFGAVLYTVSVIILVHTRTRDASIMTLSLAQTGLGAGAGLMHVSTQLIVQAAASSVFANSDRMPSQSSHAQQQQYVGVATATFLTMAQVGVAVGAALSGAIWGKLIPLKLYKYLPDTAKEDVQKIYSSVVVACSYEWGSPEREAIARAYQEVVTVLLRVALAACVLVLGSAGSVGEYVLGGDGVGRKKVRGGGGLMLRVKRLLLLGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6C9</accession>
    <name>G0S6C9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0034470</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693880.1">
        <property type="nucleotide sequence ID" value="XM_006693817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6C9"/>
    <dbReference type="STRING" id="759272.G0S6C9"/>
    <dbReference type="GeneID" id="18257485"/>
    <dbReference type="KEGG" id="cthr:CTHT_0034470"/>
    <dbReference type="eggNOG" id="KOG2416">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016396_0_0_1"/>
    <dbReference type="OMA" id="AMAMDSI"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12432">
        <property type="entry name" value="RRM_ACINU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034257">
        <property type="entry name" value="Acinus_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47031">
        <property type="entry name" value="SAP DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47031:SF3">
        <property type="entry name" value="SAP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="5"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS21584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="595" mass="67551" checksum="9F69554CC9073D1A" modified="2011-10-19" version="1">MASHWNRMTVVELRAELKQRGLSQAGNKATLIERLVEYEKEKDMEMEKDKEPENQQPAAAPEQPDDDTTSNNGNNHVAQGPDQSLDAHHNANTESPSADAAAAAAATADSQPLKTASEQLDRSNSADNNKPVDAELVPATEIISDAANRKRRSRSPPPPENESSRKRARAAEHNVKRSPERVEEPHNLDDGENYKYPQDRDRSQEQDRPPNSHNEPQVDYDRAVAPAQHPATSALYIKNFMRPLREPVLKDYLVELAALPGTSPDPSCIVSFYLDPIRTHSFVQFSTVAAASRVRSALHGTVWPNESNRKELWVDFIPEGKVDEWAAHEKEEGGRDPSCRWEVHYEPDHNGEVTARLVNAAMEHPRRNTRQPLGPPAVPTGPANNSSNPYVEGAPSGPRGRGRDRFRQGAPPSQLGASNAAGDRGGWRTTRADPPIQYRPVSEDVAQRRLANLRSHITKDRHRDLGRPDEINRYTFENSETFVDRGKEAFIGIRPPHRERERRRLGLDRRNRNRNRRAPSPRRSRDETYRGGENSRNDYERDYDRRDDFDRDRDSSRRDRRDVDDVPRSRFDGQPLPTYTGPTSRARRGGRRDRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6F3</accession>
    <name>G0S6F3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0034720</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693904.1">
        <property type="nucleotide sequence ID" value="XM_006693841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6F3"/>
    <dbReference type="STRING" id="759272.G0S6F3"/>
    <dbReference type="GeneID" id="18257510"/>
    <dbReference type="KEGG" id="cthr:CTHT_0034720"/>
    <dbReference type="eggNOG" id="ENOG502RJIP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_284270_0_0_1"/>
    <dbReference type="OrthoDB" id="37886at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="649"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="676"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="716"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="823"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="870"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="954"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="269"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="318"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="359"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="407"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="729"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="832"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="888"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1058"/>
            <end position="1072"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS21608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1093" mass="117709" checksum="DB7227B5990C0AF1" modified="2011-10-19" version="1">MKDLPAANTSSVNVTGQHETKSNHEATPTVASKKEQQQQQQQTETPSPACPEPGPRGTVNNLPKITAEEDPAFVDGNGSIQAQTTGSGAAAGRAESPSSQHPATGAPEHMMKIDGDPNGTRYPLAAPSTHQARLRWTDPMTVHDHPDWSRSQSAKSQASQQEVQKGTQRIEAPEAAQTGMRTGQSPPLPQSREPADAAGAQLDQQGQPSWPSPTPQCNQLEQPQRQPHAQPHVQRSLLSTSTPFPPPASGPVASQSHSSTLSVGSVGSQTPLQPQTPAAPIAQTLPAAHAQPGPVSSHTHPQHPQHPPPSSCQINDPQPAPAPPSSTPQSYPPAYPQSHPYPPQHTHLSTTPSAPPLPAIHHQPPQQPYHYQHPPPSQPHTPLPPSSPPRGPITKPIIMDPPSVRKAQQVQQAQAQQSPQPQAVGFPSPSLDHARINPKFIDDCTRLTYAVQQSLPEAVRRIVRDHWEKCLIGSDFHQAFILNASIHHAAPSIAQRAVRDFGRKLVSEAKHEFIGHFTAEDLDDVADLIISKASDKFLDKCLEKRLLTIEAKPLINALAKAERLGYDSSDIIQDDQHERVIPKEAFPGASTKPAPYPAQPSQAMPYPAAEQRMQCLKCFRTFIYSSAYDYHMRYNVCSQIPPTANGFEYSCPHCGQGFTNVVDLQFHGNNRACGVDQAPTKVHRGPGRPPKSAELTPQSSSTGVLSFQTLVTNGQAATPSHTAAVKRATATTPNSPSNPYAHLTEEQLHAMNEELRRAEEQFAHRFAEAEKIPDERARKAKIEGLRNSFGTKQSIIRKKYGVRLRERRTKAEIMAERERMGLLKQEKERNKAQTASPTPSTIGASSQSAVNTARAAAAVWEEHEAKRRRLDGAGGYRTPYKPVPPVANDSTPTDNTPTARKSLTIAEIGGSLSRTAATAASHDPILPDPVSHPPSTRVYKQADARIEVPEPVASTPNKQAIFKPDPPFPTSVTLSGDEDGKDVSKVDASAAADKRNDTQNGNGVLPHHQHNRALNKSVTGAQQHDLRDHDGDISMGETVQGTSTVAAAAEPSDSATDGGDESSDDDDDDDGDIPATLPAKKPVVGANGGILQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6H2</accession>
    <name>G0S6H2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0034910</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693923.1">
        <property type="nucleotide sequence ID" value="XM_006693860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6H2"/>
    <dbReference type="GeneID" id="18257529"/>
    <dbReference type="KEGG" id="cthr:CTHT_0034910"/>
    <dbReference type="eggNOG" id="ENOG502SPSM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1602496_0_0_1"/>
    <dbReference type="OrthoDB" id="4590880at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="166" mass="18926" checksum="76C033313CBFB5A6" modified="2011-10-19" version="1">MVQLLQPILRKANLPHQKQNVERDDIGIVRMTTELVMIFRTSRACFHVFITRLKKPDMSPLSIMSKFDPQTMKPVKRCSFLDPKKRSAPVDLATSPGILKTTNSDGTDYHQERVLVKPQPLGDLHGIVEVFNAQESKTKSGDRPQRSRTRSMKQNTQNDDDVVDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6L0</accession>
    <name>G0S6L0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Adenosine deaminase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0026590</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N(6)-methyl-AMP + H2O + H(+) = IMP + methylamine</text>
            <dbReference type="Rhea" id="RHEA:16001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:59338"/>
            <dbReference type="ChEBI" id="CHEBI:144842"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:16002"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693117.1">
        <property type="nucleotide sequence ID" value="XM_006693054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6L0"/>
    <dbReference type="STRING" id="759272.G0S6L0"/>
    <dbReference type="GeneID" id="18256697"/>
    <dbReference type="KEGG" id="cthr:CTHT_0026590"/>
    <dbReference type="eggNOG" id="KOG1097">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1758595_0_0_1"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF42">
        <property type="entry name" value="ADENOSINE DEAMINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="8">
        <location>
            <begin position="4"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS20821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="148" mass="16149" checksum="A82D2BA966766E3E" modified="2011-10-19" version="1">MPAAGLTKEGYIQTILDAIAEHEREQLDKPEPKLRTKLILSVDRRNTLEQAYEVLSLATRFLGKGVVGIDLCGDPAAGSISSLSAFTPVFQKARTLGLGVTVHFAEAECSGTDAELQLLLSWQPDRLGHVICVSDTMKQEIKKREDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6R2</accession>
    <name>G0S6R2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chitobiosyldiphosphodolichol beta-mannosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.142</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0035300</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.142" evidence="3"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693960.1">
        <property type="nucleotide sequence ID" value="XM_006693897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6R2"/>
    <dbReference type="STRING" id="759272.G0S6R2"/>
    <dbReference type="GeneID" id="18257568"/>
    <dbReference type="KEGG" id="cthr:CTHT_0035300"/>
    <dbReference type="eggNOG" id="KOG2941">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012079_2_0_1"/>
    <dbReference type="OMA" id="INILTPW"/>
    <dbReference type="OrthoDB" id="614844at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004578">
        <property type="term" value="F:chitobiosyldiphosphodolichol beta-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000162">
        <property type="entry name" value="Beta-1,4-mannosyltransferase (Alg1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026051">
        <property type="entry name" value="ALG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036">
        <property type="entry name" value="BETA1,4 MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036:SF0">
        <property type="entry name" value="CHITOBIOSYLDIPHOSPHODOLICHOL BETA-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13692">
        <property type="entry name" value="Glyco_trans_1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS21664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="303" mass="33053" checksum="3D695684BF22262D" modified="2011-10-19" version="1">MPFILFAPFKVIYQIAHLARLLAYTLPPAQWILVQNPPSIPALAISSLLRNPPYSISQPMLVVHDRPAAIFQPLLSNTPLSTKEEILSRVVPDSEKPLIPSIITGKTRLIVSSTSWTPDEDFSLLLDALLRYAAATTTSRQIDPPTPPPLLAIITGKGPQKAHYVSRIADLTREGRLPNVRVATAFLPFEDYAALLAVADLGVCLHRSSSGVDLPMKVVDMFGAGLPVAAYCGYESFSELVKDGENGEGFETADELAEILKRLLSENGSAQLEKLRKGAVIEGSRRWDEEWDSKVGMVLGLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G0S748</accession>
    <name>G0S748_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Peroxisomal adenine nucleotide transporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0027420</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693199.1">
        <property type="nucleotide sequence ID" value="XM_006693136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S748"/>
    <dbReference type="STRING" id="759272.G0S748"/>
    <dbReference type="GeneID" id="18256780"/>
    <dbReference type="KEGG" id="cthr:CTHT_0027420"/>
    <dbReference type="eggNOG" id="KOG0769">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_6_3_1"/>
    <dbReference type="OMA" id="PLEMINT"/>
    <dbReference type="OrthoDB" id="446044at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF1">
        <property type="entry name" value="MITOCHONDRIAL THIAMINE PYROPHOSPHATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="10"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="117"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="209"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS20903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="333" mass="35909" checksum="2F46C89726D35FF0" modified="2011-10-19" version="1">MAVQSKPAPIGPWGKATAGAAGAVLANALVYPLDLVKTKLQVQVKTADSEKGDSKEQHYASTWDALTKIMSAEGLSGLYAGMSGCLIGVASTNFAYFYWYSVVRTLYFKYSKTTAHPSTVVELSLGAVAGALAQLFTIPVAVITTRQQTQSKEERKGILDTAREIIGEDGISGLWRGLKASLVLVVNPSITYGAYERLKDILFPGKKNLSPGEAFVLGAMSKALATIVTQPLIVAKVGLQSKPPAARQGKPFKSFVEVMQFIVQHEGPLSLFKGIGPQILKGLLVQGILMMTKERVELLFILFIRWIQLMRSRQLKSGNLANAAKLVAPVTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7D5</accession>
    <name>G0S7D5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0036470</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694075.1">
        <property type="nucleotide sequence ID" value="XM_006694012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7D5"/>
    <dbReference type="STRING" id="759272.G0S7D5"/>
    <dbReference type="GeneID" id="18257685"/>
    <dbReference type="KEGG" id="cthr:CTHT_0036470"/>
    <dbReference type="eggNOG" id="ENOG502STIU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027165_0_0_1"/>
    <dbReference type="OMA" id="RRQSRNM"/>
    <dbReference type="OrthoDB" id="5386093at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408979" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="28"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS21779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="549" mass="57347" checksum="62A977B6792E22EE" modified="2011-10-19" version="1">MTTDIFESSRRPATLLLVSVLLELANAHVVHNLPRQTPAPTITLPYHVLNVVSWPLRPTPPPRRDLFALRQRQSNTVCGYIGGDSALPATCDAGSHCVLDTEHNVIGCCPDGVESCTTGVFTGCVDGNSGPQTEANPYVYSCSGGAVCYKNVFDGGYSQWGCGTASDLATTVRVSASGVSTALDHPTVTVSFTQSVTSLDEPTTLGTVTNVEVSSTSSLTSASLSSTTTSSSRLSATTASSLSSQTSITRPSSTSPDTENADVGASSTSAPSASTNANYRTGAIVGGTIGGLAVLIALISLVFFVIRRRSSNVRKGPGPGGIRSQRISPPKPQGGTGFAALTQDADAFEVPSSHTLLHYNPNPMTMSKNAPSLTATGAATAIASGALPAESNNASNNPDILPPINAGPSIPFQTPADDLDHDHSPYAYRGAESALAGSAYQPPSGYAPGSSTAYSYPVMGRTHAANDGFNSRLESDQVPLTRAAEFDEFHQGFQAALDRIGEEDEDMAHEPYRDNPTGSDSAAGNSLVPPSSRPLWQQNRRQSRNMMWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7R2</accession>
    <name>G0S7R2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">High-temperature-induced dauer-formation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0028520</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693308.1">
        <property type="nucleotide sequence ID" value="XM_006693245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7R2"/>
    <dbReference type="STRING" id="759272.G0S7R2"/>
    <dbReference type="GeneID" id="18256890"/>
    <dbReference type="KEGG" id="cthr:CTHT_0028520"/>
    <dbReference type="eggNOG" id="KOG2226">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007392_0_0_1"/>
    <dbReference type="OMA" id="IFEDDKW"/>
    <dbReference type="OrthoDB" id="432953at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000138">
        <property type="term" value="C:Golgi trans cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026705">
        <property type="entry name" value="Hid-1/Ecm30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575:SF12">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12722">
        <property type="entry name" value="Hid1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="765"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="909"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="599"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="709"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="765"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="909"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="926"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="947" mass="104696" checksum="5AECC36F3FB786C5" modified="2011-10-19" version="1">MGASDSKLVFKKGIFRLSEERHIPSDDPSWAAFWELPESAEDIFSLFAPADIRRTRDNALENLETLIQTVTGHLFMLRHHPSFPDPELAPDREALNCIRVLTRILPFIYEKEALREWEYRVFWSPRRRKTRKASIASEVLFDGGAADADGNIKTPAEDYEEVKPLAEELIDTLLDFLFFSELTVPKAPHGKPKVTYAIWQSGVGCNTSIPTTKDHENNRCEVLRLLLTLASQSMYLSPSVLPQQGVKALTYICTCPDKQTVLSVLCSLLNTTLKYNPASWRVPYNTLVFKDPREVLITYALQFLLTTLLYPIPEEPGLPTPKNYYRHYLGRLHRPQDFQFVVDGITRVLNQPLHTTAALLPGSQTTVRFAPEIIMLFWEILQCNKRFRAFIVDTERAHDFIVLILFYALEYKTDTSKQGVVRMCAFILQTLSVEKNFGVNLNKAFEAQDTLPPAIRIAGFKGTYADFLIQSIYNLITTSQGKLTAIYPALLAVINNIAAYLEGLSATTCSKLIQLFSSMSSPSFLLANETNHRLLRSLLEAMNAIIEHQYEKNAQFIYSILRHRKRFEALRSFTLESGQEEIERRNRHRKDSGADPFEPSSTRTSVDSVRSPTAPLSRAPTLGDVPEDGTFAIGDESDSDNDHETEETRPTPATSTPNDTPSAAASSAGDVDDVPRQLQGMSEKARGKLPAGSCPHDFTFSRQNSTTNLGSLSGPGPTSGMHHQAGGSFEPTAQWIDSWLPELPLHTILTVLQQLSALLPRQAISSSTSSTTPSSQSPSSATAPEYAPAIPSSTLLSQIRTTHLIGIDPSPIRIHSFEWSPLALGWYESLLWGLIFFAEMQVTARGTVGVWNAAQAGIKLFRVQETAPQGPSLTSPRGAVDAVGSNIVERIGTGLGGITLGGIGRGVVQGQGQGQRQGQGQGQTSPERRCESDGGFERGEGLPSFVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>G0S866</accession>
    <name>G0S866_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fatty acid synthase subunit alpha</fullName>
            <ecNumber evidence="3">1.1.1.100</ecNumber>
            <ecNumber evidence="4">2.3.1.41</ecNumber>
            <ecNumber evidence="2">2.3.1.86</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">CTHT_0037740</name>
    </gene>
    <organism evidence="30">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="31" key="2">
        <citation type="journal article" date="2022" name="Structure" volume="30" first="575" last="589.e6">
            <title>Cryo-EM and artificial intelligence visualize endogenous protein community members.</title>
            <authorList>
                <person name="Skalidis I."/>
                <person name="Kyrilis F.L."/>
                <person name="Tuting C."/>
                <person name="Hamdi F."/>
                <person name="Chojnowski G."/>
                <person name="Kastritis P.L."/>
            </authorList>
            <dbReference type="PubMed" id="35093201"/>
            <dbReference type="DOI" id="10.1016/j.str.2022.01.001"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (4.47 ANGSTROMS)</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a fatty acyl-[ACP] + malonyl-[ACP] + H(+) = a 3-oxoacyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.41"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 22">Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="3"/>
    <dbReference type="EC" id="2.3.1.41" evidence="4"/>
    <dbReference type="EC" id="2.3.1.86" evidence="2"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694196.1">
        <property type="nucleotide sequence ID" value="XM_006694133.1"/>
    </dbReference>
    <dbReference type="PDB" id="7Q5S">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.47 A"/>
        <property type="chains" value="A/D/F/H/J/L=1-1865"/>
    </dbReference>
    <dbReference type="EMDB" id="EMD-13846"/>
    <dbReference type="SMR" id="G0S866"/>
    <dbReference type="STRING" id="759272.G0S866"/>
    <dbReference type="GeneID" id="18257812"/>
    <dbReference type="KEGG" id="cthr:CTHT_0037740"/>
    <dbReference type="eggNOG" id="ENOG502QQJX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000114_0_0_1"/>
    <dbReference type="OMA" id="FPTLPDW"/>
    <dbReference type="OrthoDB" id="4251012at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00828">
        <property type="entry name" value="elong_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08950">
        <property type="entry name" value="KR_fFAS_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.20:FF:000005">
        <property type="entry name" value="Fatty acid synthase alpha subunit FasA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2490:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.25.70:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00101">
        <property type="entry name" value="AcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002582">
        <property type="entry name" value="ACPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040899">
        <property type="entry name" value="Fas_alpha_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047224">
        <property type="entry name" value="FAS_alpha_su_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026025">
        <property type="entry name" value="FAS_alpha_yeast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041550">
        <property type="entry name" value="FASI_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004568">
        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00556">
        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18325">
        <property type="entry name" value="Fas_alpha_ACP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18314">
        <property type="entry name" value="FAS_I_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000454">
        <property type="entry name" value="FAS_yeast_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="31" id="KW-0002">3D-structure</keyword>
    <keyword evidence="17" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 24" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 24" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-0521">NADP</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 22 25" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 22" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="27">
        <location>
            <begin position="145"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="28">
        <location>
            <begin position="1092"/>
            <end position="1630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="99"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="26">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="23">
        <location>
            <position position="1275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1748"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1749"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1750"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1851"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="25">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRNR" id="PIRNR000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="EGS21900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="31">
        <source>
            <dbReference type="PDB" id="7Q5S"/>
        </source>
    </evidence>
    <sequence length="1865" mass="204830" checksum="86A1C4E7BD8F36ED" modified="2011-10-19" version="1">MRPEVEQELAHTLLVELLAYQFASPVRWIETQDVFLAEQMAERIVEIGPADTLSVMAKRTLASKYEAYDAAKSAQRQILCYSKDAKEIYYDVDPIEEEPEPAPAQAATPTAPAAPAATPAAAPAPVAAPPPPGVGPAAQVPDAPVTALEIVRALIAQKLKKPYQEVPLSKAIKDLVGGKSTLQNEILGDLGKEFGSTPEKPEDTPLDELGAAMQATFDGNLGKTSQGLIARLISSKMPGGFNITTARKYLETRWGLGPGRQDGVLLLAITMEPPSRLGSEADAKAFLDDVSQKYAANAGISLSTAAAAGPAAGAGGGMLMDPAALEALTSDQKALFKQQLELIARYLKLDIRAGDKAYQASQESAKVLQSQLDLWLAEHGDFYASGIEPVFSPLKARVYDSSWNWARQDALSMYYDIIFGRLKTVDREIVSQCIRIMNRANPTLLEFMQYHIDNCPTDRGETYQLAKELGAQLIENCKEVLNANPVYKDVAIPTGPKTTIDARGNLKYEEVPRPSCRKLEHYVQQMAAGGKISEYGNRIKVQNDLAKIYKLIKQQHKLPKTSQLEIKALYSDIIRALQMNENQILGQTNGKSLGLPKKGKPKAKTETIPFLHLRKKSVMGWEYNKKLTSLYLDCLEKAARDGLTFAGKYALMTGAGAGSIGAEVLQGLISGGAHVIVTTSRYSREVTEYYQSMYSRYGARGSQLVVVPFNQGSVQDVNALVEYIYDTKNGLGWDLDYIVPFAAISEQGRQIDGIDSKSELAHRIMLTNLIRLLGAVKTQKASRGYETRPAQVILPLSPNHGTFGSDGLYSESKLGLETLFNRWESENWSNYLTICGAIIGWTRGTGLMSGNNIVAEAVEKFGVRTFSQQEMAFNLLGLMAPTIVDLCQNEPVCADLNGGLQFIPNLNELMTRERKNLTETSEIRQAVTKETAAENKVVNGEASEALYKKKIIERRANIKFDFPPLPDWKKDIQPLNDKLKGMVDLEKVIVVTGFAEVGPWGNSRTRWEMEAYGEFSLEGCIEMAWIMGLIKNYNGLIKGKPYSGWVDAKTGEPVDDKDVKPKYEKYILEHSGIRLIEPELFGGYDPNKKQLLHEVVIQEDLDPFQCSAETAEQFKREHGDKVEIFEIPESGEYTVRFKKGATLWIPKALRFDRLVAGQIPTGWDAKRYGIPDDIIQQVDPVCLFVLVSTVEALLSSGITDPYEFYKYVHVSELGNCIGSGMGGATALRGMHRDRFLDKPLQNDILQESFINTMSAWVNMLLLSSSGPIKTPVAACATAVESVDVGVETILEGKARICLVGGFDDFGEEGSYEFANMKATSNAVDEFAHGRTPQEMSRPTTTTRNGFMESQGSGVQVIMTAKLALEMGVPIYGILALTTTASDKIGRSVPAPGQGVLTTAREHRGKFPSPLLDINYRRRQIERRTKQVMEEKEAEFEYLAAEIEALKAEGRPQSEIEEYAAHRAAHIEKTAEKQAKEILRSFGNFFWKNDPTIAPLRGALAVWGLTIDDLDVASFHGTSTKANDKNESSVICQQLAHLGRKKGNAVLGIFQKYLTGHPKGAAGAWMLNGCLQVLNTGLVPGNRNADNVDKVMEQFDYIVYPNRSIQTDGIKAFSVTSFGFGQKGAQCIGVHPKYLYATLDEQTYNEYCTKVQARQKKAYRYFHNGLINNTLFQAKEKAPYTDEQLSAVLLNPDARVVEDKKTGQLIFPPNFMKLSEKTQAAAQPKVSLESVLSREARRLESVNTRVGVDVEDISAINTDNDTFLDRNFTEAEQKYCLASKSGRSPQKAFAGRWTAKEAVFKALGVSSKGAGAALKDIEILVDENGAPTVSLHGAAAEAAKKAGIKSVSVSISYTDSQAAAIATAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0S869</accession>
    <name>G0S869_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative myosin I binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0037770</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694199.1">
        <property type="nucleotide sequence ID" value="XM_006694136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S869"/>
    <dbReference type="STRING" id="759272.G0S869"/>
    <dbReference type="GeneID" id="18257815"/>
    <dbReference type="KEGG" id="cthr:CTHT_0037770"/>
    <dbReference type="eggNOG" id="ENOG502R16K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003021_1_0_1"/>
    <dbReference type="OMA" id="TMHQKYN"/>
    <dbReference type="OrthoDB" id="207120at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11887">
        <property type="entry name" value="SH3_Bbc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057402">
        <property type="entry name" value="AIM3_BBC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035552">
        <property type="entry name" value="Mti1_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF6">
        <property type="entry name" value="SH3 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G10320)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25459">
        <property type="entry name" value="AIM3_BBC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="57"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="265"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="476"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="811"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="853"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="900"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="143"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="532"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="582"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="648"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="659"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="684"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="713"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="756"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="770"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="857"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="918"/>
            <end position="930"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS21903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1215" mass="130550" checksum="EE6E43D28DBD6CE7" modified="2011-10-19" version="1">MVFKVKALYDYISNHEDDLNFYEGQIITVTDEEDADWYGGEYVDENGVKHEGIFPRNFVEKYEPSPPPRPTRSRPKKEAEPEHEPEPAATPPPPPPLVPAPVVEPAPERQEAPVAAPPPPPPAPASPPEPPVPAQSVEAAPISAPPVPVAAPAAPAVPHPPVPSAPATASPPVPSIPKPAPPSPKPSEERPPVAEKPVIGGSLKDRIAAFNKAAAAPIAPFKPAGLSSGSANQFIKKPFVAPPPSRNAYVPPPTQVPVAKIYRREEDPQVKDQEAEVQEQAAKAGLVTSSSTAEGAAEEDQPKPMSLKERLALLQKQQMEAAARHAEALAKKEKPKKPPKKRLESHEAAPAPAAAEGEEAEKHGLGETTTSAEESHPPRVPSGRRRSSKGPEPRDGNEADMSGAGETTEGQDDLTEKDESDSKAKHPAPPAVPKHEEDVGEEEDEEEEEEEEEEDDVDPEIRRREELRARMARLAGGAGVPGIALFGAPAPVLPKKKKAAPKPAEEEHSEPVRIAPIPLPGLMRAAPPQEPKQPEPEHEFVEQEPEKKEKEKDEEKKEEPEARQPTSPRASTPAFPSHEPEAPPPPVPGGRPAPPPVPAVPVDSRPPPPPPPAAPTAPIVKSTSEGSVSDDEYSERPGEEPDTLSGEAAPARAPAPAVGAPPPPPPPPPIPAGPPPIPSSARAFQDRNRRSIIEDASPISPPQSPSSKRDSRPPPPIPPPPVPALAPAPPIIQARPPPPPPTAAPPLRRESTTDVPPRPPPPVPKAQPQEESDQEGDEEVTEYEGDYDTDIASERLLLLLLKSLVFPLRIFGSPSTCRGPRRPPSPPKEALTYDNEYDPYNYNAAAPAAPAVAAPSAPAPSIPVAPSFPPPPPTSQPPAPAAPVTQAKQEEVYYHQEPQSYAVPQQVPRSPPPPPPSSRGRQSVDIQRSGFGHGHGRRSIDVARPSTSMDSGYVANDLDLASHTGWWLQPNGLPPQLHGRKDIFSESEESTSTDHGKTVITRDIYILYQDYSQTIITVRFNPNDQSDVQLEQRHEAPPRPPRQDQLEQAYDRFGRTIADAAAARKDTVVGDGTPHALIYDLLRPLRDALLPVGNRAYGALVYANLANASTLQNDEIRPGDILSIRNAKFQGKHGAMHAKYTMEVGKPDGHVAIVAEWDGTKKKVRAWEQGREGGSKKVKMESYKLDDLRSGEVKIWRVMPRSWIGWEGAAPGSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8L3</accession>
    <name>G0S8L3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translocation protein SEC62</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0038490</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC62 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694269.1">
        <property type="nucleotide sequence ID" value="XM_006694206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8L3"/>
    <dbReference type="STRING" id="759272.G0S8L3"/>
    <dbReference type="GeneID" id="18257887"/>
    <dbReference type="KEGG" id="cthr:CTHT_0038490"/>
    <dbReference type="eggNOG" id="KOG2927">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040936_0_0_1"/>
    <dbReference type="OMA" id="WGWQETK"/>
    <dbReference type="OrthoDB" id="200187at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004728">
        <property type="entry name" value="Sec62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011553">
        <property type="entry name" value="Sec62_asco"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00869">
        <property type="entry name" value="sec62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443:SF9">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03839">
        <property type="entry name" value="Sec62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="68"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="355"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="363"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS21973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="423" mass="46577" checksum="CF649F08AB574275" modified="2011-10-19" version="1">MAAPPPNGPMPGPMPGPMPGPIPMVMGPNGPMPMPSPEQIAAMQRQLAMDAEKAGMTVPQFIEHLRKQAAEQMQARMQQMQQQQQQQQGGGPQGGPQGGPQGQPQPQHQHPHGHPHPHPHPHPHPHQHQVMRGQPQRIVPGPPNPVAIALAKFLRSQNLKTRTCILNGERKDMFRVKRALRALQSDAYQQARKKNPALPEITDRASLENAFKLLPLSMLALRVVKAEEDDGHGHDHPPGQKPKKKKKRVKGLWTVRIEPQQEAGDDMYYVWLWEGPQVMRKVYAALALVAIFALVCYPLWPAKLRQGGYYLSWGFLCFMGLFFAMAIFRVILFCVTYFVVPPGLWLPPAAKKKKKKSKKKDGSSGSPAKEGSANAAATFAATTGQPAPPSATTTATETKVVSATPVQRTGYVAPRVEELEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8R6</accession>
    <name>G0S8R6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CTHT_0040080</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="GL988042">
        <property type="protein sequence ID" value="EGS20269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694418.1">
        <property type="nucleotide sequence ID" value="XM_006694355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8R6"/>
    <dbReference type="STRING" id="759272.G0S8R6"/>
    <dbReference type="GeneID" id="18258046"/>
    <dbReference type="KEGG" id="cthr:CTHT_0040080"/>
    <dbReference type="eggNOG" id="KOG1609">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_483956_0_0_1"/>
    <dbReference type="OrthoDB" id="1108038at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16702">
        <property type="entry name" value="RING_CH-C4HC3_MARCH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000287">
        <property type="entry name" value="RING finger membrane protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057211">
        <property type="entry name" value="DUF7889"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCHF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145">
        <property type="entry name" value="SSM4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25417">
        <property type="entry name" value="DUF7889"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="15">
        <location>
            <begin position="45"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="472"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="527"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGS20269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="563" mass="62388" checksum="DEB5BAF15205782D" modified="2011-10-19" version="1">MAENPEPFPPGPDPRLYPNTRLRPIASGALQPPFSSPLSANMTASNNNEPDTCRICRGEGSPSEPLFYPCKCSGSIKYVHQDCLLEWLSHSQKKHCELCKTPFRFTKLYDPNMPSSLPFHVFMSHLAKYLARSMMGWLRVGLVVVVWLVCLPYMMRSVWSFLFWVSDEGLGAKPVSVSGLALSESGAGVVSNVVLAGPGGAPVCAASPLFAAGMAAATIGGVIESLPPASAKIVKSLYSVNLTSSDPMYNTILRLLFGTVGLIEKPGAISGNATALLERMASAHRPTLLSEVDFLKNLTSFPAFNRTVIAILEGQFITVLVIVCFILIILVRDYVVQQQPEINMRAGFGIDANPPLAEAEVIPEPEPAPQQEDIWSDTDEDEAQIDHIEDAQRQEPRALNDPYLLEHEHEPRPGQIYRQLYQEADGDPLDILRLARDRGLEQTLADFLVPTRASLTPEELAAFEREQPVLKEAQPAAFQVERQAGPSQTQADGWDSTASEDDTAGPVENERRDRKGKARARFIEHLNDDDDEEEEEEEEEEEEGRSRLSRRERALLRARFTPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8S0</accession>
    <name>G0S8S0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0040120</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988042">
        <property type="protein sequence ID" value="EGS20273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694422.1">
        <property type="nucleotide sequence ID" value="XM_006694359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8S0"/>
    <dbReference type="GeneID" id="18258050"/>
    <dbReference type="KEGG" id="cthr:CTHT_0040120"/>
    <dbReference type="HOGENOM" id="CLU_2249829_0_0_1"/>
    <dbReference type="OMA" id="IPKRREQ"/>
    <dbReference type="OrthoDB" id="2590867at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="9"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="108" mass="11819" checksum="C6681B06AFE8F506" modified="2011-10-19" version="1">MSDILEAIKDILIPRRRSQATAETYDAQRRGPFADPNLTSQDTQQVRAAQATGNQTAERPQAQSRRGTRTSSVDSTSEYSQPSYPEVGEYAGTTTKPVHKEGGKYGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8U8</accession>
    <name>G0S8U8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0043490</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCA family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694744.1">
        <property type="nucleotide sequence ID" value="XM_006694681.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S8U8"/>
    <dbReference type="GeneID" id="18258387"/>
    <dbReference type="KEGG" id="cthr:CTHT_0043490"/>
    <dbReference type="eggNOG" id="KOG0059">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001640_2_0_1"/>
    <dbReference type="OMA" id="WKNWIVL"/>
    <dbReference type="OrthoDB" id="8061355at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001344">
        <property type="entry name" value="Related to ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001345">
        <property type="entry name" value="Related to ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF36">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="347"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="831"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="980"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1010"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1051"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1083"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1118"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1155"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1196"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="466"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1279"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="771"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS19859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1631" mass="178301" checksum="3E1CD86005CFD869" modified="2011-10-19" version="1">MLLLRQTHTLVCKTLLITLSRHRTRSWLVAFIIPIILTAFLAFARNLFVPDAQFGIGHVRPLKSLPEALKIGIDAGRKNIVFINQVHDGVGSQAVDQVIDLLKQQAETVSGASVTVWRDDSQLPWLCRASLRGVTPCFGAIQFKGAPGEDGQGMWNYTIRADGALGFGRIYVKNDDNDAEVYMLPLQRAVDMAIAKVSGIEFPELQDEYPFTSMTQDERRDYIRQLFQDVLINWLGVTFIVAPIFVVYHLAGFVATERESGISTLIDAMMAAPSPWLPQAARLMSNHIAFSLVYLPGWIVSSLTLWSNVYRHTSAAIVLIHFVLSGLALASLAILGASFFKKAQLSGVSITIILLVLAIIAQLVSEPNTATVVVLSLLFAPCNFTFFIIYLSRWEKEQLSADLSKVAPESPWNVPGIVFWIFLIIQIFVYPIIGAFVERWLHGTASSSRNIVTENNRGDLDPDVAVRLNEFTKIYSPGPLRRTFAFISKPKDPVIAVNKLSLSARRGQILALLGANGSGKSTTLDTIAGINKATAGSITIDGTGGLGIAPQKNVLWDELTVEEHIRIFNRLKSPDKPATKEEIRELVKSIDLEQKRKAQSRTLSGGQKRKLQLGMMLTGGSAVCCVDEVSSGLDPLSRRKIWDILLAERGKRTILLTTHFLDEADLLADYIAVMSRGTLRAHGSSAELKARLGGGYRIHVNNLRGIASLPEIEGVTKKASREEAAYVAPSSTMAAAVIKQLEAAGITDYRFSGPTIEDVFLTLAEEMQAGQQSALPSSADDEKSTTQEQTVTGEEADKCEDLQLLSGQPVGFLQQAWVLFRKRVVVLKSNWFPTLAAFAIPVIAAGLVMQFVKDQKAVGCSPVEQSSKEESVNIFASDFELFVVGGPDNRFTRENLARLFAPIFINSAGGSLFARDTIDPTAFLRNITAVPSLDAFNQAVVDYRKNITPAAVWLGDGSSPPLLAYRGNGAQMVNAWLGQWLMDMMLANTTIASSFVVFDTPFAPGTGNSLQLLVYLGLALCAYPAFFALYPNLERRRFVRGLQYSNGVRPLPLWLAYTLFDFLFVLVGAVIGIALFAGINPDVWYHVGYLFLVLILYGLASILLAYNIALFTRSQLAAYAFTAAGQVVALLLYIVAYMCVIAYAPVHKVDEQLVIVHFTMSLIAPITSVVRTLFVGLNIFSTACNEWELSTNPGGIMYYGGPIVYLIGQSIVLFFTLVYFDGGSAGYNLRRIFSLSAPSSLANDSSRDPPSDEEVAAELLRIKSTTTATDANAPPTDGLRVLNITKTFGRGARALTAVDNVTFGIPHDTVFALLGPNGAGKSTTISLIRGDISPSPGSGDILIENESVTRNLAAARAHLGVCPQFDAIDLMTVQEHLEFYARVRGVPDVKHNVDAVIRAVGLEPFRTRAAHALSGGNKRKLSLGIALMGNPAVVLLDEPSSGLDAAAKRVMWRTLAATGKGRSLLLTTHSMEEADALASKVGILARRMLAMGSVEGLRRKWGERLYCHVVCADGVDVERVRSWVKKRFGDGVEMEERSFLGQVRFSVPIQAIMSSEKQNDTVGSSGSVIGRMVVLLEEQRAALGIEHYSVSPATLDEVFLAVVGKHNVREEGYEAEKEKRWWDFSAIWKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8Y7</accession>
    <name>G0S8Y7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
            <shortName evidence="12">DHBP synthase</shortName>
            <ecNumber evidence="3 12">4.1.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0043900</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="12">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the DHBP synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="3 12"/>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694783.1">
        <property type="nucleotide sequence ID" value="XM_006694720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8Y7"/>
    <dbReference type="STRING" id="759272.G0S8Y7"/>
    <dbReference type="GeneID" id="18258428"/>
    <dbReference type="KEGG" id="cthr:CTHT_0043900"/>
    <dbReference type="eggNOG" id="KOG1284">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020273_3_1_1"/>
    <dbReference type="OMA" id="YNTHAVE"/>
    <dbReference type="OrthoDB" id="60371at2759"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000002">
        <property type="entry name" value="3,4-dihydroxy-2-butanone 4-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF18">
        <property type="entry name" value="3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0318">Glutathionylation</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 12" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0686">Riboflavin biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS19898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="208" mass="22287" checksum="C237DFBE02A00069" modified="2011-10-19" version="1">MPSVPEQLDPSQFDSIPDTIAAFRAGNFVVVLDDPHRENEADLIIAADSVTPDQMAFMIRHSSGLICAPITPQRASELDLPQMVSHNQDPRATAYTISVDAEHPSVTTGISAHDRALVCRFLADPTKTAADFRRPGHVLPLRARPGGVRQRRGHTEAAVELCRLAGKQPAAVICELVDDGEEVPGQAVRRGSGMLRGRSALSLRGSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0S915</accession>
    <name>G0S915_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0044190</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694811.1">
        <property type="nucleotide sequence ID" value="XM_006694748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S915"/>
    <dbReference type="GeneID" id="18258457"/>
    <dbReference type="KEGG" id="cthr:CTHT_0044190"/>
    <dbReference type="eggNOG" id="ENOG502RIV8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_528919_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="461"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="515" mass="57822" checksum="977C46424308E661" modified="2011-10-19" version="1">MVPRTQQRKRTMSDAVYCQQSSHLEEGGVKKPERNTTKRASRRRSELEERIQAYLDKERQEEIWRMQATLPDIVTPDNQSILNGLLDVILPVMVSTTKAPGKKHPFLGLFTRRMKHTLVSMDVVRFLNIEPTVLPKDSQPADTPWGLVLAEYFVELTLEQEPHGIPRQSVQAWVLPDEQRGQINVDLFIGSEFLEESTGGMLPARTIVMPTKLRSLSVLKPGTSRYAIEPFRKLAKPSIAASASRTAGFGCQVQLPSGVAQPTSQSNVSYQNLLVSLYHQQGEKRRRRSQQSPQQASALPGVQLTPPSTHQMPTAQPQPQPIAQPVVQSAFNQADQTLQDIFGPELGNVPQARDDHIATMCFHPSSSEQQQNPQALSDDFATLSQATAAADFGANLGSQLTSPNFFPQRIQSQETAADTENRILSVQIQQREERDRFKQQELHGQLRMRQQTQAQSQKPWSQSEVTTQEQSQTSQDANSVQLPQMQPVPQQQLLDQQMLAPLQIELQQDHQALMQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-06-24" modified="2025-04-09" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9A7</accession>
    <accession>G3EQ74</accession>
    <name>NU133_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleoporin NUP133</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Nuclear pore protein NUP133</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">NUP133</name>
        <name type="ORF">CTHT_0045150</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. NUP133 is involved in nuclear poly(A)+ RNA, tRNA and pre-ribosome export, in GSP1 nuclear import, in NPC assembly and distribution, as well as in nuclear envelope organization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 5">Component of the nuclear pore complex (NPC). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Nucleoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="1">Symmetric distribution.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nucleoporin Nup133 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JF276289">
        <property type="protein sequence ID" value="AEN86177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694903.1">
        <property type="nucleotide sequence ID" value="XM_006694840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9A7"/>
    <dbReference type="SMR" id="G0S9A7"/>
    <dbReference type="DIP" id="DIP-60573N"/>
    <dbReference type="IntAct" id="G0S9A7">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S9A7"/>
    <dbReference type="TCDB" id="1.I.1.1.2">
        <property type="family name" value="the nuclear pore complex (npc) family"/>
    </dbReference>
    <dbReference type="GeneID" id="18258553"/>
    <dbReference type="KEGG" id="cthr:CTHT_0045150"/>
    <dbReference type="eggNOG" id="KOG4121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002493_0_0_1"/>
    <dbReference type="OMA" id="HVATLLW"/>
    <dbReference type="OrthoDB" id="103454at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001057">
        <property type="entry name" value="Nuclear pore complex subunit Nup133, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037624">
        <property type="entry name" value="Nup133-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405:SF11">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0509">mRNA transport</keyword>
    <keyword id="KW-0906">Nuclear pore complex</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000433187" description="Nucleoporin NUP133">
        <location>
            <begin position="1"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="531"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AEN86177." evidence="4" ref="1">
        <original>S</original>
        <variation>SKHSQFSTEWTDAECTG</variation>
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P36161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="21784248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000305" key="5">
        <source>
            <dbReference type="PubMed" id="21784248"/>
        </source>
    </evidence>
    <sequence length="1364" mass="150745" checksum="F86F1F7A5B883332" modified="2011-10-19" version="1">MFSSTLHEDGPATRTRSSRRRQRPVASDSSLQTQPKAKRQRVPLTESNTAPTPTPADADAPPEMFEVKPDPVLAKRERDGIGIENIENLGPRRELSLRSKKPKSGERTSKGDGSIILTTNNAFTVSKLPALPDRLRAEPTSRQHGAIFSSGYALALTHTHAFVWPYTATTASPETFTFALPYPSKHASDPLPLGALVPPSASSDDPGLVVVMPVSGRVVYWESISSAATLDFIRQQRTGIEDAISGMYSSEHITQLVSAESAGFVLVFSSGRIAYMSVRDPHGRPGITVQYLRSPFGGASLGFLSTLRHALSGSSRGDIAAAHANHGPRVGERVVIAASSKGRLQAWKIHRGGHHEPVAEADVRERLVEAVNEADAKTQAFPSESFEVLDFAFVPRGLEPKYVNASRLSEALTHEEDSLQHMLLLVGFSRGHQARYSLVETVLAPEGARIGTVRPITSYTSPVRPGALEKPRLYLPRPALVAFVVFDRAVVVASMVAPPDSPDSQLQEDSHILPPTFEDVVDFRDDDTLQVVGSGSEEPGAGTSSEDVRPHRHKTKNPTAVLLLPGVGIVRVAITDIERFASDAPPRVTAKSKLEQAVFFGIKSDNPLVFQGRRALPFSDREVCDAAVELSHEIVNSKTPFIPSVPASLEGNMKSRSAYLDALITFLNACKVNMDERTRWMLLYDAEKMAVATWIWQKHEQFLAERPRADKKTLISEAAVFINENQKTELNVAAGQVDPVRHWFIHDIFRLDIFVAWAYQIIKYHYTQKLSDEPGLNRLVWEAVTINNGALLEARQFRLDKAAQYGVDPAVVPTGNGLPEPWTSTYFITNNLKRLTEFCHQWLAKHDAQPSADPRFDARLLDTVRERLPSLTSQYFTSLSEYITWAASSTDPETQDRCRAYQAAYAEDVYKKIVKLKEFDLWEEAVELAREFEAFDALADVVVGQILMLEAAAADPTTTESKAQENAALAQVKKQRLGRLMEEFGEGFASRAYEVLLDAAGVQAVLEFAFDRKGFITKWLRGKPELARISWVNEVLREGDVGGAAETLLGLGMSREVQVWNKKVELSLGKLALLAEGGGSDDEAGKGEVGGTIKKIDAELEVVKVQDLLYQWILASVHEAVDSSAEVELAVKQFGGLIPRRQKALLQIFEDGIARLLKHEVLDPLTLIDLLTLSSLGPGHYEGMGDQFFLALKVAHYAALENAEEVRRLIWRRCLVRDDWRQVNETNLKGDEEALEAVGETAAYRTLFACFDEESSTPTFRPHHTLKPSDCLGVYTEPEQLDSRFAAMDDSFRGKLVEAMRAEDRLLRGFVEKAQLDEWWRATRETAERMVGVAAQKGHRRVNSGSVGNGGVNGLSLNGRVKMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9L4</accession>
    <name>G0S9L4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0046310</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695010.1">
        <property type="nucleotide sequence ID" value="XM_006694947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9L4"/>
    <dbReference type="GeneID" id="18258669"/>
    <dbReference type="KEGG" id="cthr:CTHT_0046310"/>
    <dbReference type="eggNOG" id="ENOG502S6F0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_997649_0_0_1"/>
    <dbReference type="OMA" id="KNAVCEQ"/>
    <dbReference type="OrthoDB" id="21418at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029196">
        <property type="entry name" value="HAPSTR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38645">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38645:SF1">
        <property type="entry name" value="YALI0F12243P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15251">
        <property type="entry name" value="TAPR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="246" mass="26959" checksum="38B4750A1E50E501" modified="2011-10-19" version="1">MSVEANELLDAFKAAALSVTKLYKTSAAAQNKARSEGYQECLEELLGFLDRENIGLRDGEGQRIRRWVMERLDGREMSSPPPESDDEVEKPEPAPMVSPQMQRIVPSPTSAASSAQRPEDAMRDDSSLPTLTDASTNPAVEEVEFVVPTQETFTFQSSHPYPHDAALRLANLDLSDSNNRSTASRSAARNRQVRQPSASSRTSLGRGAGQKRKVNLAEIFDLGSLDYGDGKGVFGSWGNNKRTRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9N0</accession>
    <name>G0S9N0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Rhamnogalacturonate lyase</fullName>
            <ecNumber evidence="11">4.2.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CTHT_0046480</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Endotype eliminative cleavage of L-alpha-rhamnopyranosyl-(1-&gt;4)-alpha-D-galactopyranosyluronic acid bonds of rhamnogalacturonan I domains in ramified hairy regions of pectin leaving L-rhamnopyranose at the reducing end and 4-deoxy-4,5-unsaturated D-galactopyranosyluronic acid at the non-reducing end.</text>
            <dbReference type="EC" id="4.2.2.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the polysaccharide lyase 4 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.23" evidence="11"/>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695026.1">
        <property type="nucleotide sequence ID" value="XM_006694963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9N0"/>
    <dbReference type="STRING" id="759272.G0S9N0"/>
    <dbReference type="GeneID" id="18258686"/>
    <dbReference type="KEGG" id="cthr:CTHT_0046480"/>
    <dbReference type="eggNOG" id="ENOG502QTKY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037882_1_1_1"/>
    <dbReference type="OMA" id="FKIGDWD"/>
    <dbReference type="OrthoDB" id="114708at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102210">
        <property type="term" value="F:rhamnogalacturonan endolyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10317">
        <property type="entry name" value="RGL4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10316">
        <property type="entry name" value="RGL4_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10320">
        <property type="entry name" value="RGL4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000102">
        <property type="entry name" value="Rhamnogalacturonate lyase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000020">
        <property type="entry name" value="Rhamnogalacturonate lyase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029413">
        <property type="entry name" value="RG-lyase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029411">
        <property type="entry name" value="RG-lyase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016590">
        <property type="entry name" value="Rhamnogalacturonase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015364">
        <property type="entry name" value="RhgB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36574">
        <property type="entry name" value="RHAMNOGALACTURONATE LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36574:SF1">
        <property type="entry name" value="RHAMNOGALACTURONATE LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14683">
        <property type="entry name" value="CBM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14686">
        <property type="entry name" value="fn3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09284">
        <property type="entry name" value="RhgB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011794">
        <property type="entry name" value="Rhamnogalacturonase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010009831" description="Rhamnogalacturonate lyase" evidence="11">
        <location>
            <begin position="24"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase B N-terminal" evidence="13">
        <location>
            <begin position="25"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonan lyase" evidence="15">
        <location>
            <begin position="286"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonan lyase" evidence="14">
        <location>
            <begin position="372"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="53"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR011794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR011794-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGS20141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="539" mass="57839" checksum="97783B345E014109" modified="2011-10-19" version="1">MALLNAVQLFIISLTFFVSGVFGAFGYTSSGGNYVIDAGSANPLIFSVSQSNCDIKSIKYRGTELQYGNTGSHINSGLGSATVSITQINGSKRYIKVTCVTSTLTHYLVVREGDSIIYMATYITAEPSIGELRWIARLLPDKLPNEYPYGEVSNTAGSSATVEGSDVFLVNGQTRSKFYSSTRFIDEDAHCVYGGSDLIHVCILTPQQESSSGGPFFRDINSNNAGASTNLYNYMNSGHVQTEAFRMGLHGPYLMQFSRSGIPTVKNTDVSFFSELGITGYVPASGRGTVKGTATGIQRGMQGVVHWYNSQAQYWAKTSSNGAFTSPLMKPGTYTMVLYQTEFKIATTMVTVSAGQTVTQNIAGNFNTTRKTLWQIGEYDGQPTGFRNADKFLRMHPSDSRMASWGPLTYTVGSSSLSDFPMAVFKDVNNPVTIKFNLASAPGAATLRIATTLSFAGGRPQATINGWTASAPAAPTKIDSRGITRGAYRGHGEVYTVSIPADKLVAGSNTITISVISGSSGAKFLSPNFIFDAVELYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9R1</accession>
    <name>G0S9R1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0046800</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695057.1">
        <property type="nucleotide sequence ID" value="XM_006694994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9R1"/>
    <dbReference type="STRING" id="759272.G0S9R1"/>
    <dbReference type="GeneID" id="18258718"/>
    <dbReference type="KEGG" id="cthr:CTHT_0046800"/>
    <dbReference type="eggNOG" id="ENOG502QQ04">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037759_0_0_1"/>
    <dbReference type="OMA" id="FNVRILS"/>
    <dbReference type="OrthoDB" id="5345494at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="450" mass="49653" checksum="43CAB6D8E7EC75D0" modified="2011-10-19" version="1">MTQTSESRTSSLSSDLKRCALLQLLANSLVLTQTAPYLSCQDVLNLAATSRAFRFLVYRTPHVFRRLDLENVKKAQENLTVGWTDGVESQYATAEDYYSRPLRNIFAALQRLDILRDVQILSLDGLSVTAELVHDILNDPAFNVRILSIRDVKNLNEHKLRAALQYACRPSRPEGMPRLKGLYYFGARDPKPKSLSSSPDSSASSSSTRSPASLSSTTTNHSSPWPLHHALSLTLSSDLEPWWQRRGRQLPQSQISPEWADTLRACTGIIAFDAVLCTGPRHLNSPAWGTIDMEALNAAAANPNATMVKPFAVASYSLGPCEGCGAAPEGLITWGDEDWCLGGERDEFGRRLSESSSCGERDLAGRYPLLTPVPMHSASLRGAMCPEGEPHVQRSCWECGMNCKDCIADTQRTCQICGGGYCLIHNEGSDLAACDWCAGWSRRRFDRDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9Y0</accession>
    <name>G0S9Y0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0047570</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695126.1">
        <property type="nucleotide sequence ID" value="XM_006695063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9Y0"/>
    <dbReference type="STRING" id="759272.G0S9Y0"/>
    <dbReference type="GeneID" id="18258795"/>
    <dbReference type="KEGG" id="cthr:CTHT_0047570"/>
    <dbReference type="eggNOG" id="KOG0024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_3_1"/>
    <dbReference type="OMA" id="FMTPGDI"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08283">
        <property type="entry name" value="FDH_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF1">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="5">
        <location>
            <begin position="25"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS20241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="414" mass="45544" checksum="A16059A327FCE116" modified="2011-10-19" version="1">MKALVWQGKQQVAIVNVPKPKIIEDRDVILKVTGTTVCGSDLHLLHGVIMQLNYGDILGHEFCGVADEIGPGVKNVKIGKRYVASFQIACGECFYCKQKLTSQCERTNTNRLMKALYGGQTAGFFGYSHLAGGFAGGQAEYVRVPLGDVNLLEIPDDVPDEKALFLSDVLPTSYNAVKDTAVYPGDNVAIFGAGPIGQMAGIFALSEGARKIAFVDTEPRLTAISKRWPETHRDKLQLIDYQTLSFGVTDGETVVSKLKGLFDGRGPDVAIECAAGEYAKGWLHWLEMCLGAETDTSEILNEMIESVRNYGRAGVTGVYVGYTNHFNIGSLMQRGIRLIGNGQAPVHLYWTDLLEQIRGGHLDPTQMLSHRYRLEDLDKVYQKFDAKEDLIQKVFVETRFSFPRASGTPGLIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0SA28</accession>
    <name>G0SA28_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-keto-steroid reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0040790</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694485.1">
        <property type="nucleotide sequence ID" value="XM_006694422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SA28"/>
    <dbReference type="STRING" id="759272.G0SA28"/>
    <dbReference type="GeneID" id="18258117"/>
    <dbReference type="KEGG" id="cthr:CTHT_0040790"/>
    <dbReference type="eggNOG" id="KOG1478">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029944_0_0_1"/>
    <dbReference type="OMA" id="WTGINWP"/>
    <dbReference type="OrthoDB" id="9989144at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000253">
        <property type="term" value="F:3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051593">
        <property type="entry name" value="Ergosterol_Biosynth_ERG27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43647:SF1">
        <property type="entry name" value="3-KETO-STEROID REDUCTASE ERG27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43647">
        <property type="entry name" value="DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0752">Steroid biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS19600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="450" mass="49927" checksum="110B44E102574F38" modified="2011-10-19" version="1">MASAPWDRVPSENTLFVLVTGGNSGIGFGICQRVIDEYLTTRSLSSHIVVIPTTRSAKKSRETISLLRQHVRKFATTSPSSTLPRRVQVDLCNLPSIRRAANQLISGTLSTPSDLPNEDNAFETLVDVRIPRLDSVIFNAGIGGCATTWPEFKGALAGHVIDPITGKKGVGSGDVPQMGEVFCANVFGHYVFAHRLAPLLSRPAANDTSENAAILPPGRIIWETSIEPDGSHFSPSDIQATKTKAAYESTKRLTDLLALTSTLPGSRPYVESYLTPDSTKSSEKPAQLPKIYLVHPGVVQTTLFPLNAFMYFWYMVVLYLTRWLGSPWHPITAYKGACAPAWLALQQQEWLDSAGAERIKWGSSTDFWGECRVKKTEVDGWGWEGKVEDIKALRQEERWKGRKPGAKDATEESLAEFKALGAECWKRMEELRKEWEERVDEYLAKQGEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0SA29</accession>
    <name>G0SA29_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0040800</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694486.1">
        <property type="nucleotide sequence ID" value="XM_006694423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SA29"/>
    <dbReference type="GeneID" id="18258118"/>
    <dbReference type="KEGG" id="cthr:CTHT_0040800"/>
    <dbReference type="eggNOG" id="ENOG502SD7X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054588_0_0_1"/>
    <dbReference type="OMA" id="DIVLLRM"/>
    <dbReference type="OrthoDB" id="5378679at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="365" mass="40670" checksum="591622C4367797B3" modified="2011-10-19" version="1">MPKRTIILTGAPESSALDWDSAKLLSEFQDNVARFARHKRVKRDKDVASRSSGSQPKFAVWRSLSLEKKSISTGFSQQFTPSFPYIPAGSFPETATEFLTTISLSSTSDDHHVENKNNLALSQFYEHSLAMHQQDLASSQLIMTQSSVYDTTSYMSDEYTTSLLSGQGSQQPPKEPLPLRDVIVDLTNIPSAAYLERIQPQTVTCTLIVGIISISQPRMITTRWGATKHLVEVLVGDETKAGFAITYWLPSDSVSNSPLAGLRPQDIVLMQHVGLNVFSGRVYGCSLRRDLTKVHLLYRARLDSKDTGGYYSTTDLSAHSPHPQLRKTRRVRDWVINFVGQGAVGPKSKSRPRWDVRPADETQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0SA49</accession>
    <name>G0SA49_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenosine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0041000</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>adenosine + H2O + H(+) = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="4"/>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694506.1">
        <property type="nucleotide sequence ID" value="XM_006694443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SA49"/>
    <dbReference type="STRING" id="759272.G0SA49"/>
    <dbReference type="GeneID" id="18258138"/>
    <dbReference type="KEGG" id="cthr:CTHT_0041000"/>
    <dbReference type="eggNOG" id="KOG1097">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022829_1_0_1"/>
    <dbReference type="OMA" id="YQPRQTM"/>
    <dbReference type="OrthoDB" id="7202371at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000017">
        <property type="entry name" value="Adenosine deaminase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF37">
        <property type="entry name" value="ADENOSINE DEAMINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="10">
        <location>
            <begin position="290"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS19621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="619" mass="71892" checksum="3CF8BE65A142F691" modified="2011-10-19" version="1">MSAKGNKNPVVDAHEEVVRKKFGLKQPETPLLQNEIDGKLRFHGDPRISNPRANIAALWNKFFETSPSKDYDDLRLKLVNNEKTLAFDYDCERNASETERKANNIVQEIVQRDKELIYKKASKRLGFGGQEHERFYGDHFLSNRELIERTELFNLLLKMPKGGHLHIHFNANLREDFLLNIAQEMAQMYIWSSMPLVRKEDFDKCRIQFSILSDEDRDKRNRPALAKGKSVNPFDTNYSCEPKQEGARLFKDFINDFPSHIMNMDAMQWLRSKLVFHEDEAHHPCQSIAGAWEKFNGRTQMLKGLFNYETAFRKYTRACLEEFVADNIQYAEIRPNFMESNQVLKDNGSSKYNNEETLELIIEEYEKFQREHKYRILKGLKVIWCFPRSMPNDKVAGSLQECLQAKLNKRLGPYIAGFDLVGEEGQGKPLRAFRTELLTFKRLCAAQGVDIPFLFHCGETLEMGTETDGNVFDALLLGSKRIGHGFALPRHPYVMELMKQNNVCVEVCPISNEILGLTPRISGHAVYNLLANNVPCTISTDNGTPFRSRLSHDFYQIMAGKSDMTLHGLRQLIVWSIEHSCLEKERKQEVLDEWRQMWEKFCADIIREDKERKQKQSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAP8</accession>
    <name>G0SAP8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative manganese transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0043050</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694705.1">
        <property type="nucleotide sequence ID" value="XM_006694642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAP8"/>
    <dbReference type="STRING" id="759272.G0SAP8"/>
    <dbReference type="GeneID" id="18258343"/>
    <dbReference type="KEGG" id="cthr:CTHT_0043050"/>
    <dbReference type="eggNOG" id="KOG1291">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020088_4_1_1"/>
    <dbReference type="OMA" id="YEYYPRT"/>
    <dbReference type="OrthoDB" id="409173at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015086">
        <property type="term" value="F:cadmium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034755">
        <property type="term" value="P:iron ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01197">
        <property type="entry name" value="nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037982">
        <property type="entry name" value="Nramp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706:SF101">
        <property type="entry name" value="MANGANESE TRANSPORTER SMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="SOLUTE CARRIER PROTEIN FAMILY 11 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00447">
        <property type="entry name" value="NATRESASSCMP"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="449"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="496"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="80"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="528"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS19820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="586" mass="62978" checksum="467A930367E206A2" modified="2011-10-19" version="1">MASQTSDAKPLHSDNTLRATASEEHSSRYGLQQPAGPENNTNNTRNDRTKQDSTDASTTAIEETAIALCMMEERMLQAEAPNPNPRLSGLRDHTRHTHHPQPPCPGNDGDTSPRHRNENTLVRKIKDALISFARFIGPGFMVSVAYIDPGNYATAIAAGASYRFSLLFVVLLANFCAVFLQVLAAKLGTVSGLSLAEASRRYLPRWVGWGVYIVAEGAVVATDVAEVIGFAIALNLLIPSIPLVAGCALSILEVLLILLLYSPTTTGTSTGRPSRALQAFEYIVMLLVLAVIVCFCVQLSMIRGVDVGDVLKGFVPSGVLLERTALYQACGILGATVMPHSLYLGSGIVQGKVLEWEKRAMARRLSISDVARDERDGVAGRKEEYRPSLAAIRHSLRNSTLTLTLSLTTLALFVNASILIVAGASLYPLPSDSPPADLFTIHTLLTTSLSPLAGTLFALSLLLSGASAGIVCTLAGQILIEVGRKGVSAALEGSQVALSVALPVVGGVLVWLTGRKGVMTAPGHRRGHREEEDGERVKGERERAWERVRRWLLGERRMMRTEGVTMANSWGRGERGRGGEEVIEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAZ1</accession>
    <name>G0SAZ1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">H/ACA ribonucleoprotein complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0048300</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Non-catalytic component of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of rRNA and is required for ribosome biogenesis. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs. The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs. The H/ACA snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 10">Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 10">Belongs to the GAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695193.1">
        <property type="nucleotide sequence ID" value="XM_006695130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAZ1"/>
    <dbReference type="STRING" id="759272.G0SAZ1"/>
    <dbReference type="GeneID" id="18258868"/>
    <dbReference type="KEGG" id="cthr:CTHT_0048300"/>
    <dbReference type="eggNOG" id="KOG3262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080002_1_0_1"/>
    <dbReference type="OMA" id="KPQDGIV"/>
    <dbReference type="OrthoDB" id="2187159at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034513">
        <property type="term" value="F:box H/ACA snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000454">
        <property type="term" value="P:snoRNA guided rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.230:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237:SF6">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237">
        <property type="entry name" value="NUCLEOLAR PROTEIN FAMILY A MEMBER 1 SNORNP PROTEIN GAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="118"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="139"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS19371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="193" mass="19387" checksum="FCFE22E91A2EB375" modified="2011-10-19" version="1">MASRGGARGGRGGGFGRGGGRGGFQQRDAGPPATVVEMGTFVHACEGEMVVASTNPKIPHFNAPIYLENKTAIGKVDEVLGPINQVYFTIKPSEGVQATSFKPGDKFYISTEKLLPTEKFLPKPKPPPNAANKVKKPGQKGGAAGRGGRGGARGGRGGGRGGARGGARGGGAGRGGRGGGGFSRGGFRGGRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0SB38</accession>
    <name>G0SB38_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Metallo-beta-lactamase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0048770</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695240.1">
        <property type="nucleotide sequence ID" value="XM_006695177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SB38"/>
    <dbReference type="STRING" id="759272.G0SB38"/>
    <dbReference type="GeneID" id="18258915"/>
    <dbReference type="KEGG" id="cthr:CTHT_0048770"/>
    <dbReference type="eggNOG" id="KOG0813">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048478_1_3_1"/>
    <dbReference type="OMA" id="GDHVMAW"/>
    <dbReference type="OrthoDB" id="17458at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07722">
        <property type="entry name" value="LACTB2-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000328">
        <property type="entry name" value="Lactamase beta 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000041">
        <property type="entry name" value="Metallo-beta-lactamase domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047921">
        <property type="entry name" value="LACTB2-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041516">
        <property type="entry name" value="LACTB2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050662">
        <property type="entry name" value="Sec-metab_biosynth-thioest"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131:SF0">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17778">
        <property type="entry name" value="WHD_BLACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="7">
        <location>
            <begin position="32"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS19418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="339" mass="36705" checksum="ACC4B2751863B5AC" modified="2011-10-19" version="1">MTSLPALPEITPLRPGLIRILAGNPGKFTLQGTNTYLLGTGRQRLLIDTGEGKPSWIAAVKSALTSSSNQPNGEEGTATLKAVILTHWHHDHIGGVADLRKEFGPNLEIYKFPLGFGGYESPSFEAERAQEAQSTLLAQGIRPLQNNQTFTVAGATLTVHHTPGHTADHVVLVWHEENAIFTGDNVLGHGTAVFEDLATYLSSLEIMKELYSDGERSGRAYPGHGPVVDDGMAKIEEYIRHRKMREEQVLQTLRSSPGGPDGSGAGSNNKDGQHQVQPPAWTVMELVRSIYRDVPESLHPAAAGGVVQILHKLRREGRVVVVSESGDGERWSLAARSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G0SB52</accession>
    <name>G0SB52_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0048920</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695254.1">
        <property type="nucleotide sequence ID" value="XM_006695191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SB52"/>
    <dbReference type="STRING" id="759272.G0SB52"/>
    <dbReference type="GeneID" id="18258930"/>
    <dbReference type="KEGG" id="cthr:CTHT_0048920"/>
    <dbReference type="eggNOG" id="KOG2171">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003794_0_1_1"/>
    <dbReference type="OMA" id="PKRFVQE"/>
    <dbReference type="OrthoDB" id="543373at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041653">
        <property type="entry name" value="Importin_rep_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040928">
        <property type="entry name" value="Importin_rep_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041389">
        <property type="entry name" value="Importin_rep_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18808">
        <property type="entry name" value="Importin_rep_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18816">
        <property type="entry name" value="Importin_rep_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18829">
        <property type="entry name" value="Importin_rep_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="30"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS19432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1114" mass="124899" checksum="8B2BDA7A9641925A" modified="2011-10-19" version="1">MSMLPPDVSAQLVQLLQQLQSADNTVRSQAEDVLQNQWTSQRPEWLLMGLAEQIGTSSDPSLRSFAAVIFRRIASKTRKNISGENVDLFISLERQHSTAIRAKLLETLLTESDKNVRNKISDAVAEVARQYAETGESWPDLLQALFTLSQATDSGKRETAFRVFTTTPGIIERQHEDAVAGAFSQAFKDESVAVRLAAMEAFAAFYRNLRKKDQAKFHALLPELLNILPPIKDSQDSEDLSKALVALIDLAETSPKMFKPVFNVLVQFSISVIQDKELSDLCRQNALELMATFADYAPSMCKKDPNYTNDMITQCLSLMTDLGEDDDDAADWLAADDLDDPESDQNHVAGEHCMDRLANKLGGLVILQPTFNWLPRMLSSPAWRDRHAALMAISAISEGCRDQMLPELKQVLDLVVPALKDPHPRVRWAGCNALGQMSTDFAPEMQKKFYDIVLSALVPALDSPEARVKSHAAAALVNFCEEADKAVLEPYLDSLLTALYRLLQNEKRYVQEQALSTIATIADAAEQAFAKYYDSLMPLLVSVLSRESDKEYRLLRAKAMECATLIALAVGPERLGGDAMMLVQLLANIQDSIQDPDDPQAQYLMHCWGRMCRVMGKAFLPYMPKVLPPLLELASAKADVQLLDDEEQIAKFAQEDGWELVPLRGKTIGIKTSAMDDKHMAIELLVVYAQVLEEAFAQHADDIMEKIALPGLAFFFHDQVRFVSARLIPQLLRCVKKAYGSQSQQLVNLWNKTVDKLLEVLSAEPAIDTLAEMYQCFYESVEVIGMPCLTDERMSKFIDNVMSALQDFDERAKQRKEELQGLAPEELEDDQEELQEAIDDDQTLLADMNKAFNCIFKYHGVSFLPYWERLQPIYAEFLKSDDPMQIQWVLCLFDDVLEYCGPQSGGYVSFFKTPFLEGCKHPSPAIRQAAAYGIGVAARNNGKDWSEMLEQAIERLFEAVQVPSQVNMGDKTPTEEEIYKKARDEDNVYATENACAAIAKILHFYPAAVKVNPYQVIAQWFRLLPITNDEEAAPYAYLYLVELIGKQHPVVMSQPALVFQRVVEALEAETLTDQTAMRVVAATKALLQATNTDPSPVLLNFSPETQNLVRRLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>G0SC25</accession>
    <name>G0SC25_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0055650</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695896.1">
        <property type="nucleotide sequence ID" value="XM_006695833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SC25"/>
    <dbReference type="GeneID" id="18259603"/>
    <dbReference type="KEGG" id="cthr:CTHT_0055650"/>
    <dbReference type="HOGENOM" id="CLU_485704_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="561" mass="60406" checksum="A67613615E480FD4" modified="2011-10-19" version="1">MTADTFDTLILPVVAQEDDNWLSRMNANPRVENILGPRGAAIVNVITQRRNVLAAESRKLTHRAQQMDKLLSWIKKAREWAALSTQQGAGLLLSQQQPPHPPVTMSSKITGTKSQLFSSVLPQGTLRGISLDSMQSSLPLFGGDILTGQLEQQLLPGDQSLFTSAHQGMVRMGTVSAELKMQSEQMFTQGQQLQEGHGNKFMEGMLPQQQLAPGPVYPPCTPGCGMPFASQTHPAVRDSMLCHHSAGVAEHQPQHQSSSFGGGLAGTTSAKRRAVSFQSADIPFRGMAGRFTNTGRHNSGNSQRLSDQTGRRIPPNPEVHDVDKVVHQSNPELYKRLFGDKVKVQPYVPPSPFLDDDGEERLNGGEQPGQTFRGSKSFTSGQLSAHEVSMDQLTLQPTIDAGRATAEAQGQSNPLSDDQIGLTLNSQDFSQDVVLSNENFFDCQGRNLDTQRGNMNAGAAGVNLSMGTRATNPADVHDFVTVPATHPDIGGLNRSSTIAPSQSTAPTVQGRLEGVTESSFTVVAAEISTTTQNHTHSVGSDKDKELEIMMNQAIDEGSGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G0SC34</accession>
    <name>G0SC34_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Monooxygenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0055750</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695905.1">
        <property type="nucleotide sequence ID" value="XM_006695842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SC34"/>
    <dbReference type="GeneID" id="18259613"/>
    <dbReference type="KEGG" id="cthr:CTHT_0055750"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023116_0_0_1"/>
    <dbReference type="OMA" id="GQFPMGD"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045632">
        <property type="entry name" value="DUF6314"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19834">
        <property type="entry name" value="DUF6314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6314" evidence="5">
        <location>
            <begin position="584"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS18960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="758" mass="84829" checksum="3EFA32CAF29022BF" modified="2011-10-19" version="1">MTFPLAKKVCIVGAGPSGLVAAKSLLHDVPRGTFEVTIFEAKNRIGGIWPSDRNDTDGLVHPLMAANQSKHTVQFSDLAWPADSPEIPRAWHIGQYLRRYFNRYCTNVNLHLGFKVESAQPVTIGALDHNGSSQLSGWRIQARSSEGEVKEETFDFLIVASGYFSKPAIPEFRHEKPDTNVPMIHSSQFSDLQRLFDKKSPLGGKILVVGGQMSGVEIASTIAIQLSSAMHSPSANTSQAAVNNPRGYAVCHLIQKPLWILPSYISPKPDEHAPRFLPLDLVSFNLSRRPQPLTNTQGHISEDLARDFHRKYQTSLGTDQSEFCPKLTITASDTTNPPLIAISDYYLDLVRSGLITVCSGKLEALSGSQAIISPSGEHIDDIAAVVFATGFEAWPSLSFLAPLVLEVLSVRPSDLYNTVALGFHGTYHPEIPNLGFVGFYRGPYWGIMEMQARFLSSLWASGGPSSPRLPQSLKDALNNDTSLDRTIRLRSDSRSSQFPMGDYVWLMEQFASALGINRQPMHRISSLSSDHDDMDILTPARYPSKSLSEVQQAEVSESLRQTRTVVLAGISSAKFVARAVFRSLLGEWKVERDIRSRSPNYPAGYFTGTAKFLLRQGTREGHEVEFDALIQDGYPSLEYLYVEEGVFKAENGLEFPANRRYVWRYNEKTDKLSIWHIRANDRERLTVENLFHEIEFTIAQDSRGSPGWAGRGSHLCGCDFYKSYYLFNFKAVNLVHWKWMHVVKGPKKDYTLDAKFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0SC87</accession>
    <name>G0SC87_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0056330</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695958.1">
        <property type="nucleotide sequence ID" value="XM_006695895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SC87"/>
    <dbReference type="STRING" id="759272.G0SC87"/>
    <dbReference type="GeneID" id="18259671"/>
    <dbReference type="KEGG" id="cthr:CTHT_0056330"/>
    <dbReference type="eggNOG" id="KOG2058">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029367_3_0_1"/>
    <dbReference type="OMA" id="KSIPFEM"/>
    <dbReference type="OrthoDB" id="10263206at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031030">
        <property type="term" value="P:negative regulation of septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000026">
        <property type="entry name" value="Mitotic check point protein (Bub2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF263">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BUB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="317"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="402"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS19013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="632" mass="68845" checksum="ADACDA460FE6307B" modified="2011-10-19" version="1">MLHSIESILASCILATTTTKTIIALVVARSPSQRPASCGFLEFSPVPSPILDRAQKSIPFEMTLRDLNQLNKDPSPKRETLSPLVLPALPVQAHPPPGLGTMSAGTLGSLGALGNLATTGSSAGTPRRLRRLQSAHTLGAKSSAQPSFISQHRLQPAPSLQQLQPALQPTLQSVPQQNQPYRPRRSLGLASFATLAQQREQQLQQSEYQQQQQLQPPTLRKLPSPVPSPRSHASSNRSPQRARSNSDAPPMPAPVSQLNTMAQVVPRRSVLSRRSLAADAMSLERLLREGPPDGDVEGAIESTRLKILDQGIKADSDGMSSLRIYVWLILLNCPIIETDTYLALIHRGASPAYSKIRNDTFRTLTTDPLFRRRVSEASLIRLLNAIAWVLHDARESRARTPSIASSSRQSVDQSNSRPGTGYSGYSSSSHPTSSPSSKNRGRALTLTTEGSEASCYTGDHGTYVQGMNVLAAPFLYAARSEAEAFVAFHQLLTRELPGYIRGAMDGVHKGLALVDKVLAIVDPKLSLYLLSKNLSAEIYAFPSVLTLCACTPPLPEVLKLWDFLFAYGPHLNILCIVAQLVMIRNKILESPSPNKLLRSFPPLQADQIKRTTLAIIKMIPDDVYAEIVAHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCJ7</accession>
    <name>G0SCJ7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0057480</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696068.1">
        <property type="nucleotide sequence ID" value="XM_006696005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCJ7"/>
    <dbReference type="GeneID" id="18259786"/>
    <dbReference type="KEGG" id="cthr:CTHT_0057480"/>
    <dbReference type="eggNOG" id="ENOG502QPTQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007127_10_0_1"/>
    <dbReference type="OMA" id="NEQWDIA"/>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000008">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000014">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF51">
        <property type="entry name" value="MANGANESE RESISTANCE PROTEIN MNR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="782"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="377"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="623"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="144"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="418"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="462"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="624"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS19123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="808" mass="90952" checksum="DEA3BDD1D91DF29B" modified="2011-10-19" version="1">MNRPTGQTPPPSGSAPTRANPLNTPSHPGHSSRARKHHRGGKKNKKSRRKSFALLPDMAQDSVNSEGLSEAPPRFYSRPNHNLSNTSLESAALLDHRDQQPFLRPRRPSMMASASFPASQPATRSKVSGNVEHSDREDNETAPLLSNPSFQRSETITVYGSNDTSQRRSGPASRRNSSKASSHRRVQTTNYNVNYPPSVPGSPTMRPSDRLEMSFGDVLLRDDLEGDQRSPRRDSLDESGDRGAYPPSPQDRRKSIALQAQNDVCFPQEGLSDVADDELAPQETGAFRRRARRRRTKWPNLAILEEWSRMEKEGRSEERRVKKITEPQLINGRLRPVHRGWFQAQEEAPYRFTYFNEEFPSTIHSQTISELVQPGGTFKELFMPDPPILPDSSESEEEEPDSDLQQVLQGQIGAPSIPVNQPTLTSSPKDIGSRKQSGTSDKNLSSNGAGSVSAVKSQDPSKSPKSEKPPKPPKFGERPVWWLDVLCPTEAEMKVLSKAFGLHPLTAEDIMMQEQREKVELFRNYYFVNYRTFDQDQTSENFLEPVNMYVVVFREGVLSFHFSVTPHPANVRRRIRQLRDYMILSSDWISYAIIDDITDAFGPLIQAIEDEVDEIDDAVLQMHSADDPTSRDKKLQEGSGGDSAEAGRDMLRRVGDCRKKVMSLYRLLSNKADVIKGFAKRCNERWEVAPRSEIGLYLGDIQDHIVTMTSNLSHYEKILARSHGNYLAQINIRMNERQEQTADVLGKLTVLGTIVLPMNIITGLWGMNVWVPGQGAEGDLRWFSAITIGLLAFGLACYWIAKRVYKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G0SD07</accession>
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        <recommendedName>
            <fullName evidence="6">Thioesterase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0050340</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SD07"/>
    <dbReference type="STRING" id="759272.G0SD07"/>
    <dbReference type="GeneID" id="18259072"/>
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    <dbReference type="eggNOG" id="ENOG502S4UX">
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
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        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052389">
        <property type="entry name" value="Sec_Metab_Biosynth-Assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38110">
        <property type="entry name" value="CHROMOSOME 23, WHOLE GENOME SHOTGUN SEQUENCE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR38110:SF1">
        <property type="entry name" value="THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="32"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="3">
        <location>
            <begin position="166"/>
            <end position="318"/>
        </location>
    </feature>
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        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
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        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS18437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="39713" checksum="166D420E2BA3B2C8" modified="2011-10-19" version="1">MDLSASNELVPFAEATRVEKIGANVYRVNLVDSWCIGTVPNGGYVASCILQAAILHLAPRGQQDVLNAHFEYLNRTETGLAIIVIEDVKLGRQLSTIHATLYQRSLLSKEPWITPGSTRKEIAAYLVMTDLSKEEGVSLPTGFSLKHPIPPPRRPDLVALREDRDPHWAQFRFPKSAPLGYARCLKNCVFYDPRGGQPSKYVIDKWVRLASGERFTNATLGYVADCWPYVVEAQRPRPKLAEEMQRRGELVPFAPDARFWYTTVVLNVETKKALPADGVEWLQIRVQSRQIRNGRLDLEVLILDERGELIALSHHVNLILDSQRNLAERGSGSSGESKMANTKASSMRKAQSHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0SD68</accession>
    <name>G0SD68_CHATD</name>
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        <submittedName>
            <fullName evidence="4">Putative 60S ribosomal protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">CTHT_0059140</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="476" last="476">
            <title>High-resolution structures of a thermophilic eukaryotic 80S ribosome reveal atomistic details of translocation.</title>
            <authorList>
                <person name="Kisonaite M."/>
                <person name="Wild K."/>
                <person name="Lapouge K."/>
                <person name="Ruppert T."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="35079002"/>
            <dbReference type="DOI" id="10.1038/s41467-022-27967-9"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.90 ANGSTROMS)</scope>
    </reference>
    <reference evidence="10 11 12" key="3">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e56910" last="e56910">
            <title>Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation during pre-60S biogenesis.</title>
            <authorList>
                <person name="Lau B."/>
                <person name="Huang Z."/>
                <person name="Kellner N."/>
                <person name="Niu S."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
                <person name="Cheng J."/>
            </authorList>
            <dbReference type="PubMed" id="37129998"/>
            <dbReference type="DOI" id="10.15252/embr.202356910"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <reference evidence="14 15 16" key="4">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e57984" last="e57984">
            <title>Structural insights into coordinating 5S RNP rotation with ITS2 pre-RNA processing during ribosome formation.</title>
            <authorList>
                <person name="Thoms M."/>
                <person name="Lau B."/>
                <person name="Cheng J."/>
                <person name="Fromm L."/>
                <person name="Denk T."/>
                <person name="Kellner N."/>
                <person name="Flemming D."/>
                <person name="Fischer P."/>
                <person name="Falquet L."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="37921038"/>
            <dbReference type="DOI" id="10.15252/embr.202357984"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.12 ANGSTROMS)</scope>
    </reference>
    <reference evidence="8 9" key="5">
        <citation type="journal article" date="2023" name="Nat. Struct. Mol. Biol." volume="30" first="670" last="677">
            <title>Structural inventory of cotranslational protein folding by the eukaryotic RAC complex.</title>
            <authorList>
                <person name="Kisonaite M."/>
                <person name="Wild K."/>
                <person name="Lapouge K."/>
                <person name="Gese G.V."/>
                <person name="Kellner N."/>
                <person name="Hurt E."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="37081320"/>
            <dbReference type="DOI" id="10.1038/s41594-023-00973-1"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.20 ANGSTROMS)</scope>
    </reference>
    <reference evidence="13" key="6">
        <citation type="journal article" date="2024" name="Nat. Commun." volume="15" first="716" last="716">
            <title>Methionine aminopeptidase 2 and its autoproteolysis product have different binding sites on the ribosome.</title>
            <authorList>
                <person name="Klein M.A."/>
                <person name="Wild K."/>
                <person name="Kisonaite M."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="38267453"/>
            <dbReference type="DOI" id="10.1038/s41467-024-44862-7"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.10 ANGSTROMS)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696233.1">
        <property type="nucleotide sequence ID" value="XM_006696170.1"/>
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    <dbReference type="PDB" id="7OLC">
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        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="Ld=1-120"/>
    </dbReference>
    <dbReference type="PDB" id="7OLD">
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        <property type="resolution" value="3.00 A"/>
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    </dbReference>
    <dbReference type="PDB" id="7Z3O">
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        <property type="resolution" value="3.30 A"/>
        <property type="chains" value="Ld=1-120"/>
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        <property type="resolution" value="2.80 A"/>
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        <property type="resolution" value="2.19 A"/>
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    <dbReference type="EMDB" id="EMD-17004"/>
    <dbReference type="EMDB" id="EMD-17950"/>
    <dbReference type="EMDB" id="EMD-17951"/>
    <dbReference type="EMDB" id="EMD-17952"/>
    <dbReference type="EMDB" id="EMD-17953"/>
    <dbReference type="EMDB" id="EMD-17954"/>
    <dbReference type="EMDB" id="EMD-17955"/>
    <dbReference type="EMDB" id="EMD-17956"/>
    <dbReference type="EMDB" id="EMD-17957"/>
    <dbReference type="EMDB" id="EMD-17969"/>
    <dbReference type="EMDB" id="EMD-17970"/>
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    <dbReference type="EMDB" id="EMD-35286"/>
    <dbReference type="EMDB" id="EMD-35287"/>
    <dbReference type="EMDB" id="EMD-35288"/>
    <dbReference type="EMDB" id="EMD-35289"/>
    <dbReference type="EMDB" id="EMD-35290"/>
    <dbReference type="SMR" id="G0SD68"/>
    <dbReference type="STRING" id="759272.G0SD68"/>
    <dbReference type="GeneID" id="18259952"/>
    <dbReference type="KEGG" id="cthr:CTHT_0059140"/>
    <dbReference type="eggNOG" id="KOG0893">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112570_1_1_1"/>
    <dbReference type="OMA" id="EVWKQGI"/>
    <dbReference type="OrthoDB" id="9739313at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00463">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.440.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_eL31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020052">
        <property type="entry name" value="Ribosomal_eL31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_eL31_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002258">
        <property type="entry name" value="PRK01192.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01380">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54575">
        <property type="entry name" value="Ribosomal protein L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01144">
        <property type="entry name" value="RIBOSOMAL_L31E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6 7 8" id="KW-0002">3D-structure</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS19288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="7OLC"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="7OLD"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="7Z3N"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="7Z3O"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="8I9V"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="8I9W"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="8I9X"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="8OO0"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="8PV1"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="8PV2"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="8PV3"/>
        </source>
    </evidence>
    <sequence length="120" mass="13841" checksum="71875FB66C04E52C" modified="2011-10-19" version="1">MSSTQKKQRSAIADVVAREYTIHLHKRLHGVTFKKRAPRAIKEIKKFAQKAMGTSDVRLDPQLNKKVWEQGIKGVPFRIRVRISRRRNDEEGAKEKLYSYVQAVNVKNPKGLLTSVVEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDF0</accession>
    <name>G0SDF0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0051550</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695496.1">
        <property type="nucleotide sequence ID" value="XM_006695433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDF0"/>
    <dbReference type="STRING" id="759272.G0SDF0"/>
    <dbReference type="GeneID" id="18259193"/>
    <dbReference type="KEGG" id="cthr:CTHT_0051550"/>
    <dbReference type="eggNOG" id="KOG1477">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009129_2_0_1"/>
    <dbReference type="OMA" id="HIGIGFC"/>
    <dbReference type="OrthoDB" id="25503at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12909">
        <property type="entry name" value="SPRY_RanBP9_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035782">
        <property type="entry name" value="SPRY_RanBP9/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="291"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="CTLH" evidence="4">
        <location>
            <begin position="615"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="205"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="679"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="905"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="246"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="679"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="695"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="910"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS18551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="946" mass="102001" checksum="937B506AD570E23C" modified="2011-10-19" version="1">MTNPYQQQHGPLAFPGGDSLASSGMPPLSSTRRPSYASVVSGGPPASSSSRPARSSGFSHLLNPTPDTEHQQPHQTSQQQSPLRNITGFLGAYGSDSVFQTSSSSSAAATATAGSSSSGANTNNNTSEWSSRPPRTGFPHFSRAFDLYMNKEPLFPSGSFSGGPEEVRFSLANPMPNITNTGFLAPSYLRGTIYLQKLEEQHRAKLQAEREGRLAAKGQTSSVSSSTPSRLASNGSGLNLAGGYGSKSASGTSSNTSGAPSLHRGGHVYDPVERQTSGSNTNSNGGSSSSSGYSNNNSAADDDEDIAPLPSRWNKDDKDAALEVLGDGYEVRHTGRQMSEHEASAIRADHYVSPSLGVYYFEVTVLNKKKEKTPIAIGLATKEVNLGRAPGWEPGSWGYHGDDGRTFHAQNDGKPYDKPYGSGDVVGCLVNFRLGQILFTRNGQELPVAHHFDLKNIKGKLYPVVGMKKKDDHILANFGQMPFQFDIDGYMKPLSESPEQQETEEQTLLEKKKLVRSALLKHHFTFPQKQRNMIQDAIRKVDATRLAPVFKTETELADQMVLQYLLHDGYMETAQALAEELRAEREALQHNCGAQASSSAAASHINVQPDEGATNRQRIREAVLDGDIDLAFKLCETYYPDVLKENKDVYFHLRCRKFIEMIRKEAELRLALEEGPAAGRRGVGRVSSSCQQADDKDEEMLDEDDDTAAAAAHGNEDQDEEMSGITEASGISASEGVGVATASSTAASRAAAGTSGAGASTVDMEGLSKLSQDVLTYGMELQNEFPEWDEDKHRQLDEIMALIAYPNPLRVKEVAHMLDVSARTQVAEALNRAIMASLGRNSRSALENLWCQTTILLDEMRKDGGDGAFISIRKLIDEIPGCEHQPSHNQGFSFGFGLFGLQGGAEPSGAGTGAEDGNGTRNGEGAQEGQRRGRGVTVEDAVEMSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDI7</accession>
    <name>G0SDI7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0051930</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695533.1">
        <property type="nucleotide sequence ID" value="XM_006695470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDI7"/>
    <dbReference type="STRING" id="759272.G0SDI7"/>
    <dbReference type="GeneID" id="18259231"/>
    <dbReference type="KEGG" id="cthr:CTHT_0051930"/>
    <dbReference type="eggNOG" id="ENOG502S05V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_303469_0_0_1"/>
    <dbReference type="OMA" id="PPRTNHH"/>
    <dbReference type="OrthoDB" id="3254104at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="777"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="841"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="874"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="907"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="690"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS18588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="981" mass="108149" checksum="63A2C87EC051A9CE" modified="2011-10-19" version="1">MSTTQKPPGDVPRHQVPNRAGLEPPTGPSKLGSTHGTPSSAGRQGKALKAPQRLQEGAQILAQEPTKPSRATQQDDIHPTASVPKEAAPKEATKHPGMEPLEHKKPRKMDPELKPPPLTLQKGKRLAQETAPSGPQAQTDSAVPRKPIQNLTVNVPQPRGDSSGLPPRPLPKVPVSPLSTSKQVSHQEQQSTLASSGPFMPGSLPPHQQAAPKQPPLDTMKDRAESPSVRRKPIKPLSEGQSSLDSKQPQLPQVGKRVAKRGQRQREEQPDHEIQPKQTHQPPNKLAPSTKPDANRGRPRGSVKRDTKVEVAEQIPGNSRLKVPQSSRKPEPRTTLPSEAGNGPDLTQVPMPNPQRREDPTPKNMLSNETRSAQDPRPQATQPKKETNNVQSDDPKKSESSRSRRPPRAVTVEDEAAERVHAASLDRTDYNHADRKAYPGRSQVDVLLRDVKPAKSQAHLDVGSRTDQPKQQLEVSRADEPGRPEARPAPPRVPAVKIKDETGYQATSMGSAERNRSNRRLPSGSPRVNFIAGDMKTEESQAITDTRPSTSQMKHQADNIHPKEPRSEEPRRHNPRVQSLDEEKPDKSRTATENREDHSHFNQMAQPGNLQPNASIEDSIPMKSPAHRYQQPSVSRQRRVEPGPSHLQVPQQKDLSDETGSQVGEEIEYHISSNLDSLAPFSFKVKQNYSQPPKTTTFKIKHSLANKSATPPSPSIASESSTKPLNTKRRGMGTERGYASDSSDPEQGRGNFGHGSGNGTQTPYLNMIMSLDRIPRLHNILAVVFVWLLLLGFVLFPGSFTRTERQPSVSSEQPPNNNNEGTTIRVGQITVNVPLSLAQRVALVLASVFILTGVFGTAWLALRWRRNYIWLLNKLYLPLILNGLTGLGATLIAVYAQHNGEWCPQAIAVASVEGVVVVVSGGLFGGYNWCLMDRVRGFEEVKEEKREKRRKERGGRRRRVGLWGRLRGVRRKRSVAPGSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDQ5</accession>
    <name>G0SDQ5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF952 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0052620</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695601.1">
        <property type="nucleotide sequence ID" value="XM_006695538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDQ5"/>
    <dbReference type="STRING" id="759272.G0SDQ5"/>
    <dbReference type="GeneID" id="18259300"/>
    <dbReference type="KEGG" id="cthr:CTHT_0052620"/>
    <dbReference type="eggNOG" id="ENOG502SBXH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129452_2_0_1"/>
    <dbReference type="OMA" id="NDEGWDK"/>
    <dbReference type="OrthoDB" id="3335358at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.20">
        <property type="entry name" value="Protein of unknown function DUF952"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009297">
        <property type="entry name" value="DUF952"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34129">
        <property type="entry name" value="BLR1139 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34129:SF1">
        <property type="entry name" value="DUF952 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06108">
        <property type="entry name" value="DUF952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS18656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="156" mass="17616" checksum="41AD854E1CCB9F74" modified="2011-10-19" version="1">MLDTPTYVYKITHEPPPTPLPDLYPLSELDAKDGFIHLSTGWQVCLSSSSSSSSSSSSSSSSSSFLILSRCLHRNEKVPETAALYFQSFSTIYILKLRLSNFDPASVKWNEGTTRGCPHLYGRFGAKDIESVKEFRLEEGESWRKVLEEERKGWLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDU2</accession>
    <name>G0SDU2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0053000</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695638.1">
        <property type="nucleotide sequence ID" value="XM_006695575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDU2"/>
    <dbReference type="GeneID" id="18259338"/>
    <dbReference type="KEGG" id="cthr:CTHT_0053000"/>
    <dbReference type="HOGENOM" id="CLU_847312_0_0_1"/>
    <dbReference type="OrthoDB" id="4590851at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="2">
        <location>
            <begin position="10"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS18693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="328" mass="37504" checksum="14504EF8AE7D5CBC" modified="2011-10-19" version="1">MSSTACKPAPKASFLTIPPEIRLKIYDYLLVLSDPPLPHEQTVSYRCAFPLSPPPTPIHSSSSSDDECSSSKKIKSSHSPSRWTNPRQIHISILRVCRLINHEATPLLYTKNLFTPHPVHLTMAPSLYEGPDWFHLARVYHSTSSVPRPIPQKWLRHIRRWYLRLQLDAPPQWKPDQVSRALSGAEEITVELFRAGYWCSGRTRLFDQSNNDNDALSITSNNGNNADSNSAGLIHKWFPNLEGGYPDGLEIAFEINMEDEEDPDWIAKDYSIRVLWQLSEIRGVKNVRFVGLINDPRKIVSKKFLDFLKGKMMSSHMTDECGRDAMHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>G0SE51</accession>
    <name>G0SE51_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="8">ATase</shortName>
            <ecNumber evidence="3 8">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0062440</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H2O</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="3 8"/>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696559.1">
        <property type="nucleotide sequence ID" value="XM_006696496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SE51"/>
    <dbReference type="STRING" id="759272.G0SE51"/>
    <dbReference type="MEROPS" id="C44.001"/>
    <dbReference type="GeneID" id="18260282"/>
    <dbReference type="KEGG" id="cthr:CTHT_0062440"/>
    <dbReference type="eggNOG" id="KOG0572">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022389_2_1_1"/>
    <dbReference type="OMA" id="IRHFGVK"/>
    <dbReference type="OrthoDB" id="191723at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00715">
        <property type="entry name" value="GPATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035584">
        <property type="entry name" value="PurF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11907">
        <property type="entry name" value="AMIDOPHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 8 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="12">
        <location>
            <begin position="2"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="505"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS18228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="576" mass="62602" checksum="48B3531D592EF4D9" modified="2011-10-19" version="1">MCGIIGLILADSTAIDAAVDLHESLYYLQHRGQDACGIATCAAGGRIFQCKGNGMASKVFEDGKRIGDLPGYMGIAHLRYPTAGTSSSAESQPFYVNSPYGICFAHNGNLINAPALRNFLDKEAHRHVNTDSDSELMLNVFANALNNTGKARVNTDDIFSALVETYERCQGAWAVTAMIAGFGILAFRDQYGIRPLIMGSRPSATIDGGIDYMLASESIALRQLGFKNFRDILPGEAVFIQKGGKPQFHQVTPAKSYAPDIFEYVYFARPDTVMDGISVNSSRQNMGAKLADKIRSVLGEEGLKEIDVIIPVPETSNTAAAVVSERLGKPFSNGFIKNRYVYRTFILPGQKARQKSVRRKLSAMESEFKDRVVCLVDDSIVRGTTSREIVSMAREAGARKVIFASCAPPIKHPHIYGIDLATPAELIAHEKSRQDIARHINADEVIYQDLEDLKQACFAVLPKPPADSKVPVVNDFEVGVFCGEYKTEVPEGYFEHLNEVRGKKRKMAEEATPGSQTLVGNGGVVNVAGGNGNKRVAVDGDDDATPSGAQNGEQPPVVLNRQDISLHNIANEAMNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0SE95</accession>
    <name>G0SE95_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0062950</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696603.1">
        <property type="nucleotide sequence ID" value="XM_006696540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SE95"/>
    <dbReference type="GeneID" id="18260333"/>
    <dbReference type="KEGG" id="cthr:CTHT_0062950"/>
    <dbReference type="eggNOG" id="ENOG502RPXI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_298593_0_0_1"/>
    <dbReference type="OMA" id="FSEEWER"/>
    <dbReference type="OrthoDB" id="4586356at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="971"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1006" mass="109361" checksum="3DCABF2949BC6296" modified="2011-10-19" version="1">MANKKNENSQIGQRQNRKTVAQIFSEEWERNVKTTMLADLDQHRENELHLTDENEERDPRNRVNRGTENRQNGQNHNNNGGCQANQPLLNVATSLGAIWQAAIESGAFDDDEAERVKGLHDLGGARIYDKKNITVSRQQKARDLTMRILKQSAINQATQTVAQSNAPKNNKCKAQSNDAENENAGKSNAGQKGAPSVVSSDIFVKSKNSKQGSTSMTRPPPLQPPLPVRMQDFLTIESSTAPDKIIYKNKIRFLTNEIHPAMPALLYLSEDEGGKVMFTVMVWGRKYCHWPISQWKDHMAGESNYLRSVFGEPDGTIHIYDLVFDTTAQMVEFRNTAQELKDCQSNAVASTMPSAGKTVQPTVADSSGTKTVVATRARKKASISSSSSTGVDAGMLATNGVQPAYNAMKHDLLLEGFEPPICQDDDLINLDSPRDLLTRPNSPELPSWKFLCPNAVNSCAGSSESEELFLDSPANKSGSGASVLPYEQAVREFKQTCRSLLSVFLANNISGETMKEIGQTAEGIQLGVTKFIIENARSGGASKEALEKVKELIKVVVADAQFVKTRYVYSIEQLLSMREGTIAPATPLPEFSRRRRETTPRQVTLEPQLTRATADVQWLLGQDKHAAKETTASGGKSFDDSSKTICPRGDKGLQASRWATGNEVIYNNAFTGPLYSNKVRNNMAQELAQLDPETNVHNFAGMQHILDCYFPMTAINTYSSVPAWAPAQYAPPFESPHWRSDSNMRDMTIIQNRFSQFTIRSPPPETAGQHSSGGMIPSIIITDEAGSGFISTPSSLSATSHAFCRSLHPYAQISRAVQVFAPDSMVSTSRIPSTSTLAPNPVLNDLSSATSATSPIVIGDSKQRSASAWIITKGSQLQAPVHVPVKQAPVQQGLTQAAPIQSIFAQPGPIQEIPVPVSAQSVPAQQVGTPAQSTEAVSQLNVISQQAPVQHVVASQTLVLQVAAQKPPVLQDQPAWTNQTPPADPPVRGLAASRHAPCSDSGSSFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0SED5</accession>
    <name>G0SED5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyamine oxidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0063360</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696643.1">
        <property type="nucleotide sequence ID" value="XM_006696580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SED5"/>
    <dbReference type="STRING" id="759272.G0SED5"/>
    <dbReference type="GeneID" id="18260374"/>
    <dbReference type="KEGG" id="cthr:CTHT_0063360"/>
    <dbReference type="eggNOG" id="KOG0029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004498_7_1_1"/>
    <dbReference type="OMA" id="YVTFPRA"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF414">
        <property type="entry name" value="CONTAINING AMINE OXIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="69"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="539" mass="60447" checksum="AF6043B4F184D717" modified="2011-10-19" version="1">MDAKRMSFPSASRKNPKILQDLHNSRFFHSFASSSTPRPSSIMDSVRKLETLSPSSRKPLHVGIIGAGFAGLRCADILLRHGSRVTLLEARNRLGGRIHQERLPNGHLIDVGANWIHGTKDNPIYDLVVETKTPTGQLDEHTYVFDENGELLEVEESEELATVMWEVIEAGFRFSEERTGEIGEGSTLKEWFEKEIRERVPEGTMGWERRRRLLMQMAELWGNFVGSPLDRQSLKFFWLEECIEGENLFCAGTYHKVLEKVAQPARDGATIRLQTRVVEILGRSATHTGNVAVKTAAGQVLEFDHVVVTCPLGWLKRNLHAFHPPLPDRLCKAIGNIGYGNLEKVYLSFPTPFWLTPDPQTSQTVQGFCQWLAPTYAPQTNPNRWLIETVELASLPGPSAHSTLLFYTFGDQAAHITSTLRSLPDQKSREQFVFEYFRPYYSLLPSYDPQDKNCQPTAFFATDWEGDELAGNGSYANFMAGLTEADRDIEVMREGVPSEGVWIAGEHAAPFVALGTVTGAYWSGEGVGRRILDFSREGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEN8</accession>
    <name>G0SEN8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxidoreductase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0064410</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696746.1">
        <property type="nucleotide sequence ID" value="XM_006696683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEN8"/>
    <dbReference type="STRING" id="759272.G0SEN8"/>
    <dbReference type="GeneID" id="18260479"/>
    <dbReference type="KEGG" id="cthr:CTHT_0064410"/>
    <dbReference type="eggNOG" id="KOG2742">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_3_1_1"/>
    <dbReference type="OMA" id="NEMQSPE"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF5">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase C-terminal" evidence="3">
        <location>
            <begin position="171"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS18415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="510" mass="55709" checksum="4450BDF51660FCCA" modified="2011-10-19" version="1">MAGIALIGAGIFARQQHLPAIESCAGLALKAVYSRSQRSAEALAAASKDASSVAIYFDVPAVKGKSLDDLLQREDIVAVDIVLPIPHQPSVIRKALATGKHVLSEKPIAGNVVDGQELFEWYLGLGERKPVWGVAENFRFLESLAYAAQKVKEIGGLLRTFRLEKYGFVGEDNKYFNTEWRRVPQYQGGFLLDGGVHFVAALRFLLGAAGHELDKVAAFTSLLEPRLLPADTVHAVAFTKGGKSGTINITFGTEFKDVLEVEVVTTNGAVTWTPNAVTTVNRKGDCLADKAVKTKEFPYCSGVLAEVASFAQALESGRLDLRQMPAEGLKDLEVVQRMLESGEDHGVLKTVAHPAGTNYARPFPREEKGSLCGTLANKAEEAGYTIEPETVTYAHLVENVPGYILAYDGNRHPTDPAMDNEVISVTKRKGARLEAEDTVIPDAPPVHPTTPEASAHPPEDTALPVTWTRQSKERDVPDCQHKGHQRQDDCERHKYVVDRGRCLEPNDRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEW2</accession>
    <name>G0SEW2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA replication regulator Sld3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0059910</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS17978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696309.1">
        <property type="nucleotide sequence ID" value="XM_006696246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEW2"/>
    <dbReference type="STRING" id="759272.G0SEW2"/>
    <dbReference type="GeneID" id="18260029"/>
    <dbReference type="KEGG" id="cthr:CTHT_0059910"/>
    <dbReference type="eggNOG" id="ENOG502S01X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006240_0_0_1"/>
    <dbReference type="OMA" id="IYEQLGW"/>
    <dbReference type="OrthoDB" id="5395343at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013948">
        <property type="entry name" value="DNA_replication_reg_Sld3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042511">
        <property type="entry name" value="Sld3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28067">
        <property type="entry name" value="DNA REPLICATION REGULATOR SLD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28067:SF1">
        <property type="entry name" value="DNA REPLICATION REGULATOR SLD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08639">
        <property type="entry name" value="Sld3_STD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication regulator Sld3 C-terminal" evidence="2">
        <location>
            <begin position="332"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="713"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="850"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="972"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="736"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="859"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="985"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1015"/>
            <end position="1024"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1047" mass="111472" checksum="3D17ABF30FBF180B" modified="2011-10-19" version="1">MSAAAGPGPGASRLSSPPPSLTRPSSRAGPSSSSQPSTSAGVPTPVSNGDLSRRQGLPDPGSSGSASGKRKRNEPVLGMDSLLKASIVLKPYPSSLTVKPRILHPLMLLPREHLPLSALDLSQPHGDFPSSRLFESKIKILDLEGRMGSSVLLARSETTGLIYAIEPANSTNNGNGLYVLCKLGAWVDIGQLSQKALVACRERLKPKKQMKAEETDLPLTTPLLYKENKRRRLAIEEIQSIVSSKRAESQAARSRASSVVGARPPSVLGDARVPPEVSLPEKQETQAPGQSSSPAPPPAPAESVAPSSSPAKASAQDAAQEDDPFAQPSAEELFQIIRTQYMEALYHSKGSLAYFAKGPLSRARAAFQHSTDSRFSLQDLIDFLRSLIINTVLIDKKYRETIPEIVARIKTLVDDSEKGSRPKKRKRKKPKLGKDGLYPGEIEHIKKWWTALQPQQRGVDDDDDKIMSATETKFHISCLRRRETQLQIILILEILALEAQTQPPQQKDSSNEVQQQGGEPQAVDRENSQEPPAKKRNKHNLPVLLDVHADRLCIWQTTALDEVKALAETQAIADGEGAEKPKSAHSDPLRDFCVDIIIPFFSARLPSPCDALNRKLGGPIAQSPPKPKASAAAKPTGITKAKPGAPVKRVSSASKRDSSRRLERALSVERSRRSVSQGPATAIALMRSASNTVVPGLKREASEPRLLGIISSRPETAGGSLKERPVNMFPGRLGPSTGSSTTARSRANSNANNNAGAGNETSSGNSAEDLRAKRKAQVEAELRDAISTLKKPNRTAAVKEYVEAAEKRAQAAGQLKKLKKLARPSLSSTIVKATPANNRFKDALSVPPQPAVIAPTPPHNSTTAATSTQDAIPPSSASIVPQSTLPRKFTNKLSAAGDRVQATPLRSSLLSGRVDEEGDNIPPSSPAGGMFGSLFETPVAARSRAAARGSALGVMQDTPVKGGGSASRLLFPSASTSSGVAGKRGASGGLGLGDGNAVAKRAEEKSSGNNQPAVKNEKENDGEGKGLSIYQRLGWDPTDLDDIDILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0SF67</accession>
    <name>G0SF67_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0060980</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696414.1">
        <property type="nucleotide sequence ID" value="XM_006696351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SF67"/>
    <dbReference type="STRING" id="759272.G0SF67"/>
    <dbReference type="GeneID" id="18260136"/>
    <dbReference type="KEGG" id="cthr:CTHT_0060980"/>
    <dbReference type="HOGENOM" id="CLU_619916_0_0_1"/>
    <dbReference type="OrthoDB" id="18679at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="43631" checksum="9E941D6A53CDB2A9" modified="2011-10-19" version="1">MGKFSDLFRKSSDKAKTSGPDPKSSNPYADVQPSPAADPYAANLYHNAPRPGDSRRPSPHPSEGLHGPSRTSTGESNKTPPGYPNSQIGAPGGFGQNRFDKQPPNQRPGGYGSLDTDDGSSFSRYSSLSKPTQDPNVPQHASWNGGFEGEPALQEMTEEQRIDWEYNRTKFQIKAVRNDTTNTSRNILAMARQAKAQLMSQHEIIDRDDEVIERIDDHIGRADGAATTASASINEVTKSAGMMGFIGEKQRDKRRAALAQATAEKELSYKEQRRLEDAKYQEKQQALENQHRSQKRLLGQLPERELAKARKEFMLEDEESDPEELAKEREIATNTAETLSEVQDVRYLAESLNLKINRQNDRLAKISQRTDVAVDHVGKGQRQMDILLAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFG3</accession>
    <name>G0SFG3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pseudouridine synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0070710</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruD family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697346.1">
        <property type="nucleotide sequence ID" value="XM_006697283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFG3"/>
    <dbReference type="STRING" id="759272.G0SFG3"/>
    <dbReference type="GeneID" id="18261109"/>
    <dbReference type="KEGG" id="cthr:CTHT_0070710"/>
    <dbReference type="eggNOG" id="KOG2339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005281_0_0_1"/>
    <dbReference type="OMA" id="IGEYYVE"/>
    <dbReference type="OrthoDB" id="447290at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02576">
        <property type="entry name" value="PseudoU_synth_ScPUS7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TruD, catalytic domain"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011760">
        <property type="entry name" value="PsdUridine_synth_TruD_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326:SF21">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE PUS7L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01142">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50984">
        <property type="entry name" value="TRUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRUD" evidence="4">
        <location>
            <begin position="338"/>
            <end position="609"/>
        </location>
    </feature>
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        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="650"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="725"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="919"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
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        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
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        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
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        <location>
            <begin position="696"/>
            <end position="708"/>
        </location>
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        <location>
            <begin position="746"/>
            <end position="755"/>
        </location>
    </feature>
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        <location>
            <begin position="802"/>
            <end position="828"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="925"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS17728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1023" mass="114380" checksum="07B2E6BE69A67198" modified="2011-10-19" version="1">MAQRQGTHVPVVRMEAEKSLGITQRSSPDNFAWNGDIRKRYTDFLVFEIRRDGHVLHLWDFEETDAAPSQNDTAHVTSVSQAKAQADDKPTVDPISPEDRNILIALVGQQLAEQLIQLDEKIQSQSTMTPTERLVQLDPISDRAKRATIHQEIRRIFSSRIETAANPMGVITAVPSKWATSKRAVSMGFRRDNSRRDQARDRQAGQGDYLHFTLYKENKDTMDAVNTIARLLKVKASNFGFAGTKDRRAATVQRISVYRQKIKNLIWLNSRVPNVKVGDFEYCKEPLQLGQHGGNEFVIVLKNCHPVAAYGMDFTLIQRMKMIQQAVECGLAYLKRHGYINYYGLQRFGTHTIGTHYLGMKILKGDLEGFIEDILHVDEHLITEVLNSPNTPPPITANKDTREGREAQNNRDELNRARGITTWKLTKNADKALEFLPKRYSSECAIIRHLGKAPKDFNGAVLSITRGLRMMYIHAYQSYVWNHVASYRWSKYGERVIEGDLVIIKDSLPALRQSEDDEDYNPYEDQEANGPYTQARALTLTDIASGKYTIFDIVLPTPGYDVLYPRNDIGEYYVEFMGRPENGGLNPYEMRRRQREFSLSGNYRHLIGRFIKDPQYAVKAYNEDTEQLYPTDLDFAIHKKTLMAQKKKKAQASANLSAADKTAISRRRDFSQNPSAYDETVAAAARRRKADEDPDSSGNEKTLTINETYVQTSVDGSAKRIKLSRHESIKHEVSNGAEASTEGPSIPRPATPPKPSILATNLATPTKSSKSSSEDILSPELENDPRYLKIPGAGGAPLWTPEQDKGKEKEIIPEAEKQPSPPEIKETEPTPPRIIADGPIPMVTLPKDAVPSSGLRGVSDSYYASTGKVPFYGIVPASDNANEPNAPAKLLGNPYIETTKPVMSDVMNWYGGKLPSVLTPTTDGSKTDDAKGKEPAAHENNDEIDLTKEKVINGIPMPEFVTVTDDNPIGMALHDIDEASVDPNARKIAVILKFQLRQSNYATVVLRELMGTGVDGADERPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGG6</accession>
    <name>G0SGG6_CHATD</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0066260</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006696860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGG6"/>
    <dbReference type="GeneID" id="18260664"/>
    <dbReference type="KEGG" id="cthr:CTHT_0066260"/>
    <dbReference type="eggNOG" id="ENOG502RJ2Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028829_0_0_1"/>
    <dbReference type="OMA" id="GIWTFQH"/>
    <dbReference type="OrthoDB" id="5421971at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="219"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="440"/>
            <end position="530"/>
        </location>
    </feature>
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        <location>
            <begin position="400"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="301"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="352"/>
            <end position="364"/>
        </location>
    </feature>
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        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
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        <location>
            <begin position="465"/>
            <end position="479"/>
        </location>
    </feature>
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        <location>
            <begin position="495"/>
            <end position="504"/>
        </location>
    </feature>
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        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="530" mass="58611" checksum="EC931607A05EC3C4" modified="2011-10-19" version="1">MAFIQDPRLRQTWNNLSHTTEAAASDAAAGIWAFGHAYVAPCLSAVSGAIDRCCLSVCLGADREERARRARERDRGARRIEASFDFYDDWDEDLWAAAQYDDYYYDNYYDDGGLGGSGSGGGSGRRGFDWERLLAGTGSRVVGRRGGGGDGDGRGVVGDQPRRKRGMSYGTRGGGDAGRRKVTGEEDDPNVIPRTAPLGFLLRLPFKIVGSLRYKPSAANLREHPGHGAYYGENRPGEEREPLLGRNEDVQYGRRSPVQRQQEESKQQQQQSPGRARSNTTMSGDTSSSYRSRNDLFSSDGEGDEDAVPLDDEFTVALARVSCPGGDDRSSNKMRSSKGKGKRPDGERGLSRTYSRTTMASSVKTTSSRRSTADEASLKDLGQSIYSTRSLGLDGEYEYHDEVVRSLENLRREEEDVEREENEEIERKRRAAERLAMQKGLAVNVAAGHTGTEQQQQQQQQQQDSEQREAHSRDQETRPKPNGSVTEHLIEESKPVPPTSPEAPLPKDDDDKKPGNGESRFNAARLPRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGI1</accession>
    <name>G0SGI1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0066410</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006696875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGI1"/>
    <dbReference type="STRING" id="759272.G0SGI1"/>
    <dbReference type="GeneID" id="18260679"/>
    <dbReference type="KEGG" id="cthr:CTHT_0066410"/>
    <dbReference type="eggNOG" id="ENOG502SWQJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_357142_0_0_1"/>
    <dbReference type="OrthoDB" id="5430717at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="380"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="749"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="303"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="772"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="785" mass="87783" checksum="C8D15A1F49624E96" modified="2011-10-19" version="1">MTDSNSASSGSSWFRPFSRARNNVPAASQPNSSDSTESPQLQRHPSPEQPVCHSTNFSPSPSPSPTTTTFSSPRRPPVPPRPKSTTNLHQQAQQHELRQSPPSRLHVPHHSRPSLSMSATLGRRPASSNPLKHVSSFLKMELHGLRGSHKERGREQDVLGDDVDREKDDQNQVEEEVQDEVAKDGDEEKVKKKERGRKAELHPAMKILAPTSTTLSPLMDSSKEERRDSYGSRSGNDSTTGRNAQKGRTRDPLSEWHSPKVWEMMETLKSVMMTKDARDGLPAKYSSYVLTLLEGFICLTQRLHEATNELSELKTLRDKELEEFRDLSEEWLQRENDYKAEIKRLELVLAKESKDGVGCVAVSRHNSIVDRSGSKRFQARVKRARSPQRGDGRKGIMMAWPTQSRPPSANDKSYEISATLPRILDSQNDVLMSRFIERREREDRLLNSHLHLGPGTTYNPPIAQDHRRSDVKPFEPKAVQGTAIDRNTLAEQLATNMKGSESNSSGKDYGFEIPQRTKPQRQPIFTISTSDSGSSTESAIEPLSSSSGSAVEQHHIGNQAKDPPQITILTSPSVDDTTKEELRAAMQEPLPFQPLSEDIALSDRTTRCFSFQEGDDRVLPVLSPQAWESEIYDLERIPHRRGYWEYDKTSTVFNRAEIEQPGTGLGNGMTGHTVENSDVKPGNDVLFPLGPDTDASPASHSECLCSSSGLGPDQPVYLQGSFYDSYLHRQEFPEQARMSSQDRALMNGHRRLSHSESTGSVVWIGDSVSQEEQQKKSDTIKKNEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGR5</accession>
    <name>G0SGR5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0067290</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697022.1">
        <property type="nucleotide sequence ID" value="XM_006696959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGR5"/>
    <dbReference type="STRING" id="759272.G0SGR5"/>
    <dbReference type="GeneID" id="18260767"/>
    <dbReference type="KEGG" id="cthr:CTHT_0067290"/>
    <dbReference type="eggNOG" id="KOG1166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002115_1_0_1"/>
    <dbReference type="OMA" id="NCEKGVG"/>
    <dbReference type="OrthoDB" id="248495at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13981">
        <property type="entry name" value="STKc_Bub1_BubR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.430:FF:000003">
        <property type="entry name" value="Checkpoint serine/threonine-protein kinase BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015661">
        <property type="entry name" value="Bub1/Mad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013212">
        <property type="entry name" value="Mad3/Bub1_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012572">
        <property type="entry name" value="Mad3/Bub1_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030:SF4">
        <property type="entry name" value="BUB1 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030">
        <property type="entry name" value="MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08311">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08171">
        <property type="entry name" value="Mad3_BUB1_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00777">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51489">
        <property type="entry name" value="BUB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0137">Centromere</keyword>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="3" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BUB1 N-terminal" evidence="7">
        <location>
            <begin position="78"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="857"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="253"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="474"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="562"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="684"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="739"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="571"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="632"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="696"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS17404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1179" mass="132993" checksum="11AA0E6F2E11C4D4" modified="2011-10-19" version="1">MPPSRRGERTAAPMTAPAEPAPVDFSIIESHKENIQALPSGRSARKLADLFTRSPLAQQATPTSLANRPEIERARAEFEEEIKNLGESDDPLDVYDRYVKWTLDTFPSAQNTKESGLGELLERATREFVRWGEYKNDVRYLRLWVYYIQWFCDAPREAFVYLARNGIGEGLAMYYEEYAGWLESVGRWAQAEEVWKLGIEREARPVGRLVRKFGEFERRWERVRQEEGEEGGPRSPAIPPVRRALAERVDPFSLDAAPRDPQAQRQDARGVGGAASKPKSKLQIFSDADSKQQQPAIPAKSGSGSSASSKGWDSIDTMANRKKENVMEPKPWAGETLKQASGTKKPAGPKLQVFRDPLQVTVNPATGKKERVFVDLRAVYPTPDEPGTELSFEEVWARNRGWLDVEWESEEEEEAVSMMMDETAITEMGERTPVAGSRMVRLDENGNPILTREVRNRKKKVIEKMANTPTVKVNLDSPTGPRTLKKKKKRRSTIEPSVMSVSSYEMPTTMTIHTKEAQDDIYDIFNAPEAHRATGEISQFDRQFESDDYTCGETTYMTNKSSVRGDITRVEEEDEDGEEENDGASEWSEFSRKDVHGLDGPSTADTTGNSDLIDMREDCPPQQSRPRSSFIPVPPEDYVPPPRRPYRDPTELASRRLPFMTPITERTETSLTCLTAARSVLGKTPCRDRKGASPLMEEEEEEEEEDAENQGPESPSRGDGFGSGRKMRLPMMQKSVPVFREEERSQGQAGQRRPFAPKPAQPLAPKTPLAPKGPVIKEQQVNPMDEGIRLQILKQLSPSLTSYGGFFDNTNQTHGRAAEIRKYIKTISKNRSSTDKAASSLNGTGIVLSFPGAKGRYTIRRELGAGAFAPVYLVDNSAPDEDEDEQSETHDENAVIRRGSPYLRRRAREAIKMEDPPSTSAWEFYMMRLAHSRLGPQHRATASLSPALELHLYRDEGFLVMPYYPHGTLLDVVNFFRSAESSGVMDEVLAMFFAIEVLRTVEALHTKGILHGDLKPDNCLLRLPDESDVQNQHLVAQWTPSGAGGWAARGIVLIDFGRAIDMKMFRDDVAFIADWKTTPQDCAEMREGRSWTWQIDYHGIAGILYCLLFGKYIETVRVPGGNGRRYRIRESLKRYWQQEIWSEAFDLLLNPGEACYGNNGYEFVTVRNLMDGYDNGYHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGV7</accession>
    <name>G0SGV7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enhancer of polycomb-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0067730</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the enhancer of polycomb family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697064.1">
        <property type="nucleotide sequence ID" value="XM_006697001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGV7"/>
    <dbReference type="STRING" id="759272.G0SGV7"/>
    <dbReference type="GeneID" id="18260811"/>
    <dbReference type="KEGG" id="cthr:CTHT_0067730"/>
    <dbReference type="eggNOG" id="KOG2261">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010580_1_0_1"/>
    <dbReference type="OMA" id="HIKWNEG"/>
    <dbReference type="OrthoDB" id="435275at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024943">
        <property type="entry name" value="Enhancer_polycomb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14898">
        <property type="entry name" value="ENHANCER OF POLYCOMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Enhancer of polycomb-like N-terminal" evidence="9">
        <location>
            <begin position="7"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="302"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="474"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="537"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="482"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="545"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="582"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="601"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS17446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="610" mass="70671" checksum="04A6DE5218D4BB78" modified="2011-10-19" version="1">MSTRKVRYKKLSVKTTLAVLREHQIDPSEYEQLSTEAQIATGVEQAEENEYHLQTVLKTTGLAADKEIPVPPPQKSELNYDELYFRTYSKPASYIRFSQTVEESVGCMYDMNEDDEAFLKEYNKKRPPSAQLSEDDFERIMEVYEETAQIKTPFAAIDQTIVPYDDMLQGLQEIENCKTKIMPHAKEVYEYWKSRRQASGNKPLQPTIKFETHQETDDMDPYVCFRRREVRQTRKTRARDVQSADKLKRLRKELEEGRQLVLASHQRELLKYELLKADRDIYETRLQLKQQKIRLGIKTDDEDLVNQKERPAPPKRKASEVPAVQRPPPPTQLRITVRSSDGRPPEQDLALLSDRLAEKENELRADIEKKVQSHSEWNRHHVDLTRGPLSPVRGPQPEVSFRPAKTQYLMTPPASTSSEEEPMKMDLDKPEFPPHVFQFRGVSQPEQMAEHRPAYPAYRRRIGRLNRLWIDRRGLASPPHDINPEVADRWKYDQSSDDEDEPPQYEVDPFDTRALKFRASIPLPSWLTARVALGPRPSLLPPGHPQHQQLAQAQAQAQHHGQHGQQPHPQQQQQQQQQQKQPPHPQQPPAPMQSPQPPQQQRPQPTAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0SH20</accession>
    <name>G0SH20_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA primase large subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0068380</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic-type primase large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697127.1">
        <property type="nucleotide sequence ID" value="XM_006697064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SH20"/>
    <dbReference type="STRING" id="759272.G0SH20"/>
    <dbReference type="GeneID" id="18260876"/>
    <dbReference type="KEGG" id="cthr:CTHT_0068380"/>
    <dbReference type="eggNOG" id="KOG2267">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026253_1_0_1"/>
    <dbReference type="OMA" id="RINYKPW"/>
    <dbReference type="OrthoDB" id="421393at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07322">
        <property type="entry name" value="PriL_PriS_Eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.80:FF:000003">
        <property type="entry name" value="DNA primase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058560">
        <property type="entry name" value="DNA_primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016558">
        <property type="entry name" value="DNA_primase_lsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007238">
        <property type="entry name" value="DNA_primase_lsu_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537:SF3">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04104">
        <property type="entry name" value="DNA_primase_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26466">
        <property type="entry name" value="DNA_primase_lrg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009449">
        <property type="entry name" value="DNA_primase_large_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA primase large subunit C-terminal" evidence="11">
        <location>
            <begin position="301"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR009449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR009449-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS17509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="503" mass="58546" checksum="85396C05ACFE1A34" modified="2011-10-19" version="1">MIRQDFNRIDAKRRNVVDYRKKQFADPLYKETQYPHRLNFYATPPTADITLEQFEQWAIDRLRILAELEACSFRNKTPAETAAYMKPLLDKYLPLDANSSSSSQLHSQRQKDHYSHFILRLAFSSTEELRRRFARVETMLFRLRFQTDDSRERAAFIRSLNIEWEPVLEDEKGELSQQLIVTAGFGYGKRAQQVMDEDWYKVDWTRVPDLIEGRKVFVKAGKAYVPGPLQHSIIMNEFTRRLERALELTARALPRLDEDDRLTPILNHLSKNFIAPDSSYSGSATAVEGAEISARNIDNLAQHFPLCMQHLHNTLRRDCHLKHYGRLQYTLFLKGIGLNLEECLIFWRTAFKKISDDTFNKEYRYNVRHAYGDVGGDANRRSGGYSPFSCQKILTEHAPGPGEAHGCPFRHFSMDNLTTLLRSAGVSDRAVLQGIQEDKESQKYHMACNRVFEYLHKTELKRAKEEGIFTAVQLETIVHPNEYFKRSYLLKNMSKQRDVKMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHC1</accession>
    <name>G0SHC1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0069500</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697228.1">
        <property type="nucleotide sequence ID" value="XM_006697165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHC1"/>
    <dbReference type="GeneID" id="18260988"/>
    <dbReference type="KEGG" id="cthr:CTHT_0069500"/>
    <dbReference type="HOGENOM" id="CLU_2133235_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="113" mass="12958" checksum="5568D1E62120ADE4" modified="2011-10-19" version="1">MPIAPNSLDAPILMIVILTVICVVILYAMGIWLLVHRLRGTDPELPRLLLLRRSSDEEQGQLYDFGDLISMMLARHRGRRERQFQAQLRAAGRRVGEFGPNETTPLLSDQRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHD9</accession>
    <name>G0SHD9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0069680</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697246.1">
        <property type="nucleotide sequence ID" value="XM_006697183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHD9"/>
    <dbReference type="STRING" id="759272.G0SHD9"/>
    <dbReference type="GeneID" id="18261006"/>
    <dbReference type="KEGG" id="cthr:CTHT_0069680"/>
    <dbReference type="HOGENOM" id="CLU_179722_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="100" mass="10988" checksum="667EC7393A57DEB8" modified="2011-10-19" version="1">MTAEFEDQDDNYVSEEDSDFAPDDAAEEDESLSSDDDEAAEGESAPAKPDRKRPAADSSADDVGFENSGDEAIIERGKKNKRDIRKKLAPTRIGRKRTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHF0</accession>
    <name>G0SHF0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Histone acetyltransferase type B catalytic subunit</fullName>
            <ecNumber evidence="3 9">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0069790</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalytic component of the histone acetylase B (HAT-B) complex. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the HAT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 9"/>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697257.1">
        <property type="nucleotide sequence ID" value="XM_006697194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHF0"/>
    <dbReference type="STRING" id="759272.G0SHF0"/>
    <dbReference type="GeneID" id="18261017"/>
    <dbReference type="KEGG" id="cthr:CTHT_0069790"/>
    <dbReference type="eggNOG" id="KOG2696">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036024_2_1_1"/>
    <dbReference type="OMA" id="WTCDAND"/>
    <dbReference type="OrthoDB" id="10253098at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.360.10">
        <property type="entry name" value="Histone acetyl transferase 1 (HAT1), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019467">
        <property type="entry name" value="Hat1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037113">
        <property type="entry name" value="Hat1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017380">
        <property type="entry name" value="Hist_AcTrfase_B-typ_cat-su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013523">
        <property type="entry name" value="Hist_AcTrfase_HAT1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12046">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE TYPE B CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21184">
        <property type="entry name" value="HAT1_C_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10394">
        <property type="entry name" value="Hat1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038084">
        <property type="entry name" value="HAT-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histone acetyl transferase HAT1 N-terminal" evidence="14">
        <location>
            <begin position="6"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with histone H4 N-terminus" evidence="11">
        <location>
            <begin position="44"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with histone H4 N-terminus" evidence="11">
        <location>
            <begin position="207"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="458"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="486"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="259"/>
            <end position="265"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with histone H4 N-terminus" evidence="12">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR038084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS17639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="509" mass="57735" checksum="0B3C0937EAAEB188" modified="2011-10-19" version="1">MSEEAWSMPSNDAIVLSLVAPTPNGLKTVGHSFHPKFTYSIFGEAEEIFGYQNLQIQLRWHASDLRPNLSISYSKKFQAVGDTEPVDIEGALREFLPDSAFQKKSDWEKAMSNVPQDWTPPGKLIRTFTAPNGTFEVWKGNLADPAVAQLLNRVQILVPLFIEGGTKINTDEPDADRWTVFFLYQKKELTDSCCTNPYVFVGYCTVYRFFHFQPPSPPATPSETKLEEMDQVLRKGDFDLNLLPCRSRISQFLVIPPFQQRGIGTRLYSIIFQDYIQHPQTVEITVEDPNEAFDDLRDVADLHYLRRMPEFRALHLNTGIVLSKNGPAPNNIVDKTAYDAVRAKAKITPRQFARLVEMHLMSQLPETVRPGIGVEEDNARGKGKAKVKMPTPEDKHAYRLWRLLVKKRLYKHNKDALSELDVEDRVQKLDDTVSSVEFDYARLLVKAEDQAENFEEILPAQPADGFKEKDKAVTNGSPATNGTGKRKADEDRAVEMASKRARVEDADDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHQ3</accession>
    <name>G0SHQ3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sm protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0072980</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="15 16 17" key="2">
        <citation type="journal article" date="2025" name="Cell Res." volume="35" first="296" last="308">
            <title>Structural insights into spliceosome fidelity: DHX35-GPATCH1- mediated rejection of aberrant splicing substrates.</title>
            <authorList>
                <person name="Li Y."/>
                <person name="Fischer P."/>
                <person name="Wang M."/>
                <person name="Zhou Q."/>
                <person name="Song A."/>
                <person name="Yuan R."/>
                <person name="Meng W."/>
                <person name="Chen F.X."/>
                <person name="Luhrmann R."/>
                <person name="Lau B."/>
                <person name="Hurt E."/>
                <person name="Cheng J."/>
            </authorList>
            <dbReference type="PubMed" id="40016598"/>
            <dbReference type="DOI" id="10.1038/s41422-025-01084-w"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.80 ANGSTROMS)</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the snRNP SmB/SmN family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS16973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697555.1">
        <property type="nucleotide sequence ID" value="XM_006697492.1"/>
    </dbReference>
    <dbReference type="PDB" id="9L5R">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="e/p=1-211"/>
    </dbReference>
    <dbReference type="PDB" id="9L5S">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="p=1-211"/>
    </dbReference>
    <dbReference type="PDB" id="9L5T">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.50 A"/>
        <property type="chains" value="p=1-211"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHQ3"/>
    <dbReference type="EMDB" id="EMD-62841"/>
    <dbReference type="EMDB" id="EMD-62842"/>
    <dbReference type="EMDB" id="EMD-62843"/>
    <dbReference type="SMR" id="G0SHQ3"/>
    <dbReference type="STRING" id="759272.G0SHQ3"/>
    <dbReference type="GeneID" id="18261336"/>
    <dbReference type="KEGG" id="cthr:CTHT_0072980"/>
    <dbReference type="eggNOG" id="KOG3168">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_1_1_1"/>
    <dbReference type="OMA" id="KMINYRM"/>
    <dbReference type="OrthoDB" id="2020720at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070990">
        <property type="term" value="F:snRNP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01717">
        <property type="entry name" value="Sm_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000047">
        <property type="entry name" value="Small nuclear ribonucleoprotein SmB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="15 16 17" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="6"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="143"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="146"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS16973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="9L5R"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="9L5S"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PDB" id="9L5T"/>
        </source>
    </evidence>
    <sequence length="211" mass="21404" checksum="D65F384FDB6F9460" modified="2011-10-19" version="1">MSSSQNRQGKMAGYINWRMRVTLNDGRQMTGQMLAFDKHMNLVLADTEEFRKTKRMQAKPNSSTTQTLIQEEKRTLGLTIVRGANIIALSVESPPPADPSARLGKTTGAGIASTLTAGPGVARPAGRGAAAPISLAGPAPGVGGAVPPPPFPGFPAAAPPGFPGRGGPAPPGFPAAPFPPPAGFPGAPGFPPGFPPGGAPPPAGFNPPPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G0RXV1</accession>
    <name>G0RXV1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial</fullName>
            <shortName evidence="7">Glu-AdT subunit B</shortName>
            <ecNumber evidence="7">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0000490</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="7"/>
    <dbReference type="EMBL" id="GL988030">
        <property type="protein sequence ID" value="EGS24117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690603.1">
        <property type="nucleotide sequence ID" value="XM_006690540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RXV1"/>
    <dbReference type="STRING" id="759272.G0RXV1"/>
    <dbReference type="GeneID" id="18254087"/>
    <dbReference type="KEGG" id="cthr:CTHT_0000490"/>
    <dbReference type="eggNOG" id="KOG2438">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019240_4_1_1"/>
    <dbReference type="OMA" id="ARKWWMG"/>
    <dbReference type="OrthoDB" id="1722066at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="GatB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004012">
        <property type="entry name" value="PRK05477.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="GLUTAMYL-TRNA GLN AMIDOTRANSFERASE SUBUNIT B MITOCHONDRIAL AND PROKARYOTIC PET112-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659:SF0">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="GatB/YqeY motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Asn/Gln amidotransferase" evidence="8">
        <location>
            <begin position="435"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS24117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="623" mass="68865" checksum="7FA672D6DC994342" modified="2011-10-19" version="1">MGRIPTAELSRYLLYGQLSRRGCLRGGITRISTTSALRQSRFFSTQIDTPAGAAPANVPLTPLRKELKEQAKALKASGKKKKKNSDNQTVPGWELTVGIEIHAQLNTARKLFSPAATSFNDTPNSHVALFDVAMPGSQPLFQAETLIPAVRAALALNCTIQPISRFDRKHYFHWDQPAGYQITQYYHPFARDGRVMLYARDGIAAEDGECIEIGIRQIQMEQDTAKTTAVPGNVHWLDFNRVGVPLIEIITLPEIHHPATAAALVRKVQMLLNSVDACVSGMETGGLRADINVSVRRVQDIATGKLGTRTEIKNLSSFKAVEDAIIAERDRQIAILEAGGVVLGETRGWSLGNTETRRLRGKEGEVDYRYMPDPDLGPVVIGEDLVQHLKGTLGVLPDAEIDELIELYGLTTKDAMSLIQLDNGARIQYFYNVLDSLEERLRAAGSASPNSDSPAGQRHALLAANWCLHELGKLTEVSADLGMTPDGECNVPSVDLAAILFHLHRREITAKVAKELLWAVFRGQIPRGKVTQAIEADDLWFNELSEQDYAELADKVVEGEDKVLAEFLRFKQGKIKAYPQGKLMFLVGKIMRAGPEGRMDPESAKRVLRDRIEHVYLPHMEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYJ4</accession>
    <name>G0RYJ4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0006910</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691222.1">
        <property type="nucleotide sequence ID" value="XM_006691159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYJ4"/>
    <dbReference type="GeneID" id="18254729"/>
    <dbReference type="KEGG" id="cthr:CTHT_0006910"/>
    <dbReference type="HOGENOM" id="CLU_157377_0_0_1"/>
    <dbReference type="OMA" id="WGCEISP"/>
    <dbReference type="OrthoDB" id="2251794at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409140" evidence="1">
        <location>
            <begin position="22"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="114" mass="12095" checksum="00834A103FD2FB85" modified="2011-10-19" version="1">MQFLSIRTITFLFLALPSALAKAGGPCAPPYNSDNDCICYDKARCESMHGFTIVGSPGNWPCPDDLSNIVGCKKVGCDPKGRGSYCAFGCRPGYSKIPDPVCPGGNDFFCCVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYM9</accession>
    <name>G0RYM9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0007260</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS24015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691257.1">
        <property type="nucleotide sequence ID" value="XM_006691194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYM9"/>
    <dbReference type="STRING" id="759272.G0RYM9"/>
    <dbReference type="GeneID" id="18254764"/>
    <dbReference type="KEGG" id="cthr:CTHT_0007260"/>
    <dbReference type="eggNOG" id="KOG0750">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053371_0_0_1"/>
    <dbReference type="OMA" id="GQPWFSD"/>
    <dbReference type="OrthoDB" id="409947at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001409">
        <property type="term" value="F:guanine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000010">
        <property type="entry name" value="Probable YHM1 (Mitochondrial carrier)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053042">
        <property type="entry name" value="Mito_GTP/GDP_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46974">
        <property type="entry name" value="MITOCHONDRIAL GTP/GDP CARRIER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46974:SF1">
        <property type="entry name" value="MITOCHONDRIAL GTP_GDP CARRIER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="213"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS24015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="33256" checksum="BCA4C261385B1987" modified="2011-10-19" version="1">MSPPIAAAAGREKESNLARLLGSGSAGIAELAIFHPVDTIAKRLMSNEGKVTSLSKLNTVIFKDKANASFGRKFVSLFPGLGYAAGYKVLQRIYKYGGQPVARDFLSTHYAKDFEAAFGKKTGKAIMHSTAGSLIGIGEIILLPLDVLKIKRQTNPEAFRGRGIFKIIKDEGFGLYRGWGWTAARNAPGSFALFGGSAFAKEFLFHLQDYNKATWFQNFVASICGASASLIVSAPLDVIKTRIQNRNFENPESGFRILANMAKNEGPTAFFKGLVPKLLMTGPKLVFSFWLAQTLIPAFDVAFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYS4</accession>
    <name>G0RYS4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">EDC4-like protein pdc1 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0007720</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat EDC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS24060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691302.1">
        <property type="nucleotide sequence ID" value="XM_006691239.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0RYS4"/>
    <dbReference type="GeneID" id="18254810"/>
    <dbReference type="KEGG" id="cthr:CTHT_0007720"/>
    <dbReference type="eggNOG" id="ENOG502T19D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003635_0_0_1"/>
    <dbReference type="OMA" id="YVNPFDQ"/>
    <dbReference type="OrthoDB" id="21128at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000817">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055393">
        <property type="entry name" value="Beta-prop_EDC4L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045152">
        <property type="entry name" value="EDC4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15598">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15598:SF5">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24106">
        <property type="entry name" value="Beta-prop_EDC4L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="EDC4-like protein pdc1 beta-propeller" evidence="8">
        <location>
            <begin position="560"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="500"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="997"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="562"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="166"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="338"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="502"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="519"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1012"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1052"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1064"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1113"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1144"/>
            <end position="1155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS24060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1659" mass="179930" checksum="F7A476F4BD319735" modified="2011-10-19" version="1">MSSYGLPGASPAGSGPATDTEANQDFQSLLAQLRRQSSPSPGPGGGSSGPGPDMLPPPHGQYGYNNYAAQPYYAGVHHSGSDSPNAPNPSHVQTSMDSPAFLPEAPTPPVSYSHSQYPPGLMSTMNATRAGPPAPSDDRTAHLLNLLKYNSQNGPPSTSQQASREPPLPYAPAPIGPPPVIHAPAPAAADPTGLLAALMKGTLPETSKPEPPSTSTWNQGSPPTGTQQYLLNLLNRPKPSQHGDLPEAPQPPVMDEKDAESSHGGRSAEPTLVDTLASRSELDYEPKSFESPPPKFDSTPHSQHSHPVSKPPVPAVFPGFQDAYDHLSGSSPIHRTPKTSTTPSAAAETAHPVAPVPTQILKKPTSVQHTPEQKRSIVETPEHLLRKPEHSASPGSQGIAAPIFPLPAVSDALPVQEKKESVADAVSGLAEQADREAREALARAEYEQAQARELEPPAPEEAAPAVLSPPIAGDLASKQQGDAFLASTLDVAVGVKEEKDSGNNAAAPAAHGPVADSWESAEAEEAPAPEEPPAPVTVYNFPMKPWISISLQEIEDTRPVFREEAILDIARLKKDFDQMDRNLVSASETYMAYGMSKAGGLRVIRQEDGKDAKLFTDTKDRIFNVAISTSAAHQHPGKEAIIGTGVSGTVTALPCPPIQAQEGGDAPGGVLKTRARPSSMHPEYFAVGRGKSINIIWPSFIFENNLFKTGHDRVVDTDRLMKQCSLKINTGKAGKDFTFSQDDTVVVSLDKSGRVKFWDVRELTAPKEDSDLLSPLPAHTSFEVKEPLMTLTTTPEGEKAWPTSVLLLDKFRPYQKRVALRYMIVGMKQNHTLQLWDLALGKPVQEFNFPHNKESDAVCSVMYHAASNMIVVGHPTRNSIYFLHLSAPKYNLKNMSQVEYIQRLVAQDPSIPQPESTAVISGIREYSFANKGVLRSLNILENPAASGDGEEPTLFELYAMHSKGVTCLFIKQAELGWSRENKVISPADAVESGLAKISKLVPPPPPPPAETQHANAPTESAAQPPPQIRIATRNKDAGLKIPTPPSDEKTPKSTAAESGSTLKTDQRKDNNKEEVELPVPAPERTERKGRKKKSSQQAAAAVSNDHPGANAPGESNNNRATLQNNKAGKGSRNMTDNNLTDAKQQQQQQQQQAAADLSLLSSGVSQEHLENIVNKMESRIVANISGRFDAVFNEILKQMQTFQDSRDSAFANNQSTLLQMVADVLNDNTEAVLKNLIISQINDHVIPSLRSTIDKSVADQLGAKTSAQIGAVKNEVSRNLNQAVANAMMKPDVAKTITERIVHNLAITVSSSVEKEVQKSISTLASNVAKQTAHLVHQRILEDVDARIREAFQHFEERRRDDDTRLDRLMAQTQELADIISTLAASQTQLQRELVALRQQISEQGRERAVHLAAEEQLMHGHGHHARGSASSHTMPGAGRELVSYPHSTQASVSHQQAPHVYAHQPQHQYGTPEQQQVMYGPSSREERQKMELNNLLDTIDGLMRSGNYSDAMLRWLQSGDRTEEIFQQVLSNYNPMFAQDLPPLVLLSVGATVSRELSRGAPKLTKKISLLEIILYSFNQHIGNLDDQVRDVTPKIMRDLKSRIEQLLLDISRIAPHDPSIKTLSGLSQLASRIAESVQSVQVRHASMHGPVGHMGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYV1</accession>
    <name>G0RYV1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aspartic-type endopeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0000670</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690621.1">
        <property type="nucleotide sequence ID" value="XM_006690558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYV1"/>
    <dbReference type="MEROPS" id="A01.081"/>
    <dbReference type="GeneID" id="18254105"/>
    <dbReference type="KEGG" id="cthr:CTHT_0000670"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035052_0_0_1"/>
    <dbReference type="OMA" id="GLQWGST"/>
    <dbReference type="OrthoDB" id="15189at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF47">
        <property type="entry name" value="ENDOPEPTIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01220)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408769" evidence="5">
        <location>
            <begin position="21"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="6">
        <location>
            <begin position="99"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS23379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="450" mass="48790" checksum="88308EEE30B4FF7A" modified="2011-10-19" version="1">MTRVAWIVLFGGLAGAKLHAEVLKHAPPGISYHVPKGILPTYSSKVVSVNHHVHQLRPVSTRHGFAMNLNSKSAASVLGIHQRHAGGFGYENITTTSAYGTQYAIEATWDGHPLSLLIDTGSSDTWAVSKDFHCIDYTGQFLPQSSCGFGEAYPDAFQYGRTDPPTHMFIQYGDGEIVTGPMGFSDITIGNITVKKQQVCLANTTYWFGNNYTSGLLGLAFPSLTNAYYGDSGTDHDYGSQVQYSPLFTSMVSQGLVDPLFSIAIDRNASSGMISFGGIAPAVGADFSRSATLDMIITNIIGVPATAFQYSFYTVIPDGWYFDSTMNTKKYPYIVDSGTTLNYLPPSLADAINAAFTPPAVYMWMYGAYFTSCDAIAPQVAVVLDGEKFYINPVDLIYRTMVDPLTGLCMTAIASGGSGPYILGDVFMQNALVVFDVGEAKMRFIPRPHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZ86</accession>
    <name>G0RZ86_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CTHT_0002080</name>
    </gene>
    <organism evidence="23">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690756.1">
        <property type="nucleotide sequence ID" value="XM_006690693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZ86"/>
    <dbReference type="STRING" id="759272.G0RZ86"/>
    <dbReference type="GeneID" id="18254246"/>
    <dbReference type="KEGG" id="cthr:CTHT_0002080"/>
    <dbReference type="eggNOG" id="KOG0215">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000524_5_1_1"/>
    <dbReference type="OMA" id="LAYCSWC"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000020">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14 22" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="18">
        <location>
            <begin position="45"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="195"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="19">
        <location>
            <begin position="458"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="20">
        <location>
            <begin position="560"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="642"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="15">
        <location>
            <begin position="689"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="16">
        <location>
            <begin position="1064"/>
            <end position="1149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EGS23514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1157" mass="130002" checksum="B35CD05FB1EFE1F5" modified="2011-10-19" version="1">MAPAPLDDGFEALLEPFYNGKKLTDPISTKEDKYQLLPAFLKVKGLVKQHIDSYNFFVEHEIKDIVRANRSIRSDQEKDFWLEFTDIRVLTPTRNDYSDFKARDEVTPMECRLRDMTYAAPVVVDIVYSRDRKRIVRKDIPLCRIPVMLKSSKCVLSKATNAQMEIMNECPLDPGGYFIINGTEKVILIQEQLSKNRVIVEADEKTGGVQASVTSSTHERKSKTYVILKKDRIVLNHNVLVEPIPIVIVLKALGGLSDYQILELVAGGDALYQDDFLVNFDEATRAGVFTQQQALEYIGLRVKMGGSKKGRSPNAPRRSPVEEGLDALTNLIIAHITIEDLDFYPKAIYIAMMVRRVLMAAHNPKLIDDRDFVGNKRFELAGQLLSLLFEDQFKMFIASLKGNMEYFFKKPNRTSAYDPVGPISSQGQYITQGLNRAIQSGNWTVRRFNMNRAGVTHVLSRLSYISALGMMTRISSQFEKTRKVSGPRALHPSQWGMLCTSDTPEGEACGLVKNLALMTHITTNADEEPVKDCIFDLVPGVEPIRVFTGSEMHRPGSYIIHLNGTPFALTRHPKQFAARFRTLRRRGHISPFVSIHTNEHFSAIHIATDEGRICRPYIIVKDGKSRLKPEHLRLLQLGKASFDDFLRLGVVEYLDVNEENDALIAMNEDEITRATTHMEIEPFTILGAVAGLIPFPHHNQSPRNTYQCAMGKQAIGAIAYNQFNRIDTLLYTLVYPQRPMVITKTIQLIHYDKLPAGQNATVVVMSYSGYDIEDALVLNKASCDRGFGRCQVFRKYTAELQQYANGRKDRLGGPQKDEEGRTIAKHACLDRDGLAIVGYQIRSGETMIMKETPVDVTSTGIGGDRGSDAYVPAPVNYRINDPAYIDKVMVSNTEKNTAIIKVQTRQTRRPELGDKFSSRHGQKGVVGIIVNQEDMPFSDSGIVPDIIMNPHGFPSRMTVGKLFECLTGKAAVVAGRPDYGFGDAFRSHPVEEMGRVLIEHGFSWEGKDYFTSGITGNPHEAYLFNGPIYYQRLKHMVQDKMHSRSRGPRAILTRQPTEGRSRDGGLRLGEMERDCLIAYGASQLLLERLMISSDATQVDVCEACGLFGYKGFCQTCQSTANVTQMTMPYAAKLLVQELISMNVGVRMQLEDKFPHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZL5</accession>
    <name>G0RZL5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0003380</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690885.1">
        <property type="nucleotide sequence ID" value="XM_006690822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZL5"/>
    <dbReference type="GeneID" id="18254376"/>
    <dbReference type="KEGG" id="cthr:CTHT_0003380"/>
    <dbReference type="HOGENOM" id="CLU_2637855_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="77" mass="7964" checksum="4DE8A4F03318440A" modified="2011-10-19" version="1">MPVRIISPPQHHPIGYLIVEPGGVAAPRRQDGGGPTHERPHANQGAGVGRARTGILARSGAVLGALVGRFDNEGEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZR8</accession>
    <name>G0RZR8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0003940</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690938.1">
        <property type="nucleotide sequence ID" value="XM_006690875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZR8"/>
    <dbReference type="GeneID" id="18254432"/>
    <dbReference type="KEGG" id="cthr:CTHT_0003940"/>
    <dbReference type="eggNOG" id="ENOG502RYIG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_298758_0_0_1"/>
    <dbReference type="OMA" id="WRCKILR"/>
    <dbReference type="OrthoDB" id="3524154at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="856"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="263"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="409"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="523"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="278"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="538"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS23696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1005" mass="110638" checksum="7EB0663EDB21E5F5" modified="2011-10-19" version="1">MAIRTHKWKPSKPTVPDSNFQKELQHYAPRLARLDWRRTRHPAYTHLSVSKTAKAIDTFELLRECRCDISFIHPSAVVVDSGLDLGQANAAPSVPSTNVDREVLAEGGRVDSSRVENITYILRTMQLEDADQFMAPIKARWATGSPSLSSSAWGRTAAPAGGCTTMQKEGDASPRRLGASPSRGLGFSEKGRAPVLLPLRTKRRPFTEVAGVLGDQSTNLKGSLVGVLGCRACFRGSWTATRNDSLEGYPVGGGLKQRTRSDWMAPFSSPAPAGGDTSARRLDDGYRGLGPDTRESRIMDTTYQTVVPEDSGVSTAGNVSVESLGGFGTVAGVKNAIPLTGSGAPSLTDPMELDIDIDTISWAGDLDFTVRRLEPDHLDLSIGVQNTNQPSNPPADVLFAEDESVLPSSAASSTSFDGQRRTAPSSGSQLIPAPTSLLQTQSFPVSTPGMNAADPRQLDKTLYNYGLASERLRRQLSLLSKGWAGDEIRFKNCDPTKAVILHQFAIELGLGYNHDVRTREVSMSRLDPVTPASNPQTSARRPSSSMPRSSTELDSALCLPTLPVFQGTVFAEAATPFLARHDKGQSIPARRCLSVDVAERCLLSAESQRLADMKAVFEGASYKLSISDAKHRAYFVAFIEAGRYRDHESLHTSYSVSGKTYTYTELIAIIAWELAENHGLLSLLEIKEWNNFMNMIETACIYESEIGQTSLVILSVICLRHCLEALRLHSAQLLTPSAHEDCCGGRCQVECIQNLTTRIAAYIDELSAVIFNKENMRDRRWWLSTFYSLYIQSYVRHALIAIEKILRFRVLDDAPTEDLAATQYLHLPTILFTAASAKYDPLFDGRLQQHEAEKPHPCTQCKKRFKSPTEAERHINAIHLKSDSWSCKALENCLLAFQSETFNGVVWDVCGFCGGGFARNHSKGNSDENGVIGGDSNEATPEHKAELVSHLESVHKIGECDRNKKFYRADNFRQHLKNTHVAKPGKWLKTLERVCRTTREEEPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZS2</accession>
    <name>G0RZS2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="5">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Endo-1,3-beta-glucanase btgC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Laminarinase btgC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CTHT_0003990</name>
    </gene>
    <organism evidence="24">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation. Active on laminarin and lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 20">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="5"/>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690942.1">
        <property type="nucleotide sequence ID" value="XM_006690879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZS2"/>
    <dbReference type="STRING" id="759272.G0RZS2"/>
    <dbReference type="GeneID" id="18254437"/>
    <dbReference type="KEGG" id="cthr:CTHT_0003990"/>
    <dbReference type="eggNOG" id="ENOG502QTKT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011476_0_0_1"/>
    <dbReference type="OMA" id="QYPDCLK"/>
    <dbReference type="OrthoDB" id="68336at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000151">
        <property type="entry name" value="Glucan endo-1,3-beta-glucosidase btgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF17">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BTGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0134">Cell wall</keyword>
    <keyword evidence="15" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 23" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="156"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="371"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="371"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00037649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00043078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EGS23700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="716" mass="78369" checksum="7E626870E23AC0DF" modified="2011-10-19" version="1">MEQHRYYSDDLGERQPLSSGVFSSYRPQQQQYRQPYPPYHDAYNSHSETWARAHPDTAFDGFQGQTHHNGREASNRLATSPYAAAGGDPPKLSPHRDPEGHYWAHNSPYPPATAQSSPYGYPSSQRTFGTSPSFGNVSNSFVAGAMSSSVAMNSFEHHPRRSAEQDHGSVDRGLLTPGEYHSGDRNSHGSMQGLAATAAPTGQSTPGQRASFYTDDPYQNLSRHVDSDLGVVNPQDIADDGDDGLEYGRKGPRTSMLSLGSSRGAGANAVGGAASSGMLNSTSGRNGSGSVNNQYASINNADVTSGGSGSIYNAGAAIGGAEKGEWQAEAIPKKSRRWRLVVIFLLGAIVLGAIIVGILLGVVFKNKDKNASASTDDSSSGSSVSTAEEDLATNGDLNKNSPEIKALLNNPNLRKVFPGIDYTPLNTQYPECLTFPPSQNNITRDMAVLSQLTNVVRLYGTDCNQTEMVIHAIDRLELKGTVKIWLGVWQDNNATTNERQLNQMWNILDKYDHDYFKGVIVANEILFREQMTIWSLGQLLEEVRLNMTGKGYSLPVATSDLGDRWDATLASKSDAIMANIHPFFAGEPATSAAKWTRTFWKNKAGDFMKKDKSMNIIAETGWPSQGGTGCGNEFEIYCPQKAVAGIKEMNIFMEDWVCEALEDGTNYFWFEAFDEPWKVRFNTEGKEWEDHWGLFDVNRNLKPGLKIPDCGGKRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0A7</accession>
    <name>G0S0A7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Diphthine--ammonia ligase</fullName>
            <ecNumber evidence="1">6.3.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Diphthamide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Diphthamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0009350</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphthine-[translation elongation factor 2] + NH4(+) + ATP = diphthamide-[translation elongation factor 2] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19753"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10174"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16692"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.14"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.3.1.14" evidence="1"/>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691459.1">
        <property type="nucleotide sequence ID" value="XM_006691396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0A7"/>
    <dbReference type="STRING" id="759272.G0S0A7"/>
    <dbReference type="GeneID" id="18254973"/>
    <dbReference type="KEGG" id="cthr:CTHT_0009350"/>
    <dbReference type="eggNOG" id="KOG2316">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2317">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010289_2_0_1"/>
    <dbReference type="OMA" id="HCRLAQS"/>
    <dbReference type="OrthoDB" id="686384at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017178">
        <property type="term" value="F:diphthine-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01994">
        <property type="entry name" value="AANH_PF0828-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06155">
        <property type="entry name" value="eu_AANH_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06156">
        <property type="entry name" value="eu_AANH_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1490.10:FF:000004">
        <property type="entry name" value="ATP binding L-PSP endoribonuclease family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1490.10">
        <property type="entry name" value="putative n-type atp pyrophosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002761">
        <property type="entry name" value="Diphthami_syn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030662">
        <property type="entry name" value="DPH6/MJ0570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196:SF2">
        <property type="entry name" value="DIPHTHINE--AMMONIA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION 71 DUF71 -CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01902">
        <property type="entry name" value="Diphthami_syn_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphthamide synthase" evidence="7">
        <location>
            <begin position="205"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="46"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="152"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="680"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="683"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS23268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="832" mass="88891" checksum="3CC1D5E004818F48" modified="2011-10-19" version="1">MSASDAGLNVIGLVSGGKDSFFSLLHCQANGHRIVALANLHPERSSMPATLDGTSSSPSPAAAPTASVAASLVPVLDPAGKVHSPDQDESPATTSPDHPSGPLANEAAPRQDEDESDLNSFMYQTVGHQVVPLYSEATGIPLYRRAITGRATQSGKEYSHYRRPTSSVTEAGAGPAPSPDNKEVGSGTQGSGQNSGHGAPGAELEEDETESMMPLLMRVKEEHPEANAICAGAILSTYQRTRVESVATRLGLTPLAYLWKFPVLPAPASLDPALGSDAQLLDDMAVAGLEARIIKVASGGLDESFLWTNVTSTAGKARLAKAMRRFGTAETGAIIGEGGEFETLVVDGPPSLFKKRIVVDEKDQKVVREEGGTAWLSLRNARLESKDILENDSKPDIRIPDLLDPRFVGVLDTLLSPQTSEGTLSDQTYGDKQDIPSSLDLQRLKIAMSTLHEWGFVSDKPATIEQETQDLVEKIRQRLQETSLSPSAIISATILLRHMADFPTVNRIYSSLFDAPNPPSRVTISCGDVLSVTTKGSIAISLTVHTALQPGQRQGLHVQSRSYWAPANIGPYSQAITIPVMSLASAESLNDSTSSTGTLLVSIAGQIPLVPATMSLPAVPPNGSNLELQLTLSLQHLWRIGIEMGVCWWTSAVAFFPASSSGEDMDLKVRLTARAWQRAHVAEDEDDGEEEDDDEDDGPDLWDRRYNPAYTTFASADEGGRKKGPSLPDRSVLSPTVPKGVVPPVFVAEVNELPRSASVEWHAHWGVAHAPEGAVKVTRDVLKAGSSATKCEENNQERQFFVSHVIISSNIETSGSSAPSEVVVVQTIVAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0P1</accession>
    <name>G0S0P1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0010720</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691593.1">
        <property type="nucleotide sequence ID" value="XM_006691530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0P1"/>
    <dbReference type="STRING" id="759272.G0S0P1"/>
    <dbReference type="GeneID" id="18255110"/>
    <dbReference type="KEGG" id="cthr:CTHT_0010720"/>
    <dbReference type="eggNOG" id="ENOG502S2HP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043442_0_0_1"/>
    <dbReference type="OMA" id="KLNALGH"/>
    <dbReference type="OrthoDB" id="66510at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028241">
        <property type="entry name" value="RAVE2/Rogdi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13618">
        <property type="entry name" value="LEUCINE ZIPPER CONTAINING TRANSCRIPTION FACTOR LZF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13618:SF1">
        <property type="entry name" value="PROTEIN ROGDI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10259">
        <property type="entry name" value="Rogdi_lz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="393" mass="43153" checksum="5CBD926247FE1E29" modified="2011-10-19" version="1">MSIDIYPPLPPDHLQREVKAAQVCLPRSWKELQQLTVQQRELEWFVAELRETLVNIKHGLEDCYALLAPIDPGSTLVLSTPRNEIVKGTVTRVGTRIVKGTIHLRLRTLPHQTLTLNPDHPIHLAPLTSLQSLLNQSIDLLTLTLSYSYPSEPSQDHQPSSTPQFLSAQLRLLSQHISRASALLKGAPLPTTDPAWTSRSAAPSHFTPPLAQPHSGSSTPALSFYLTIQDACLVLWLRTLEPFDAPVAFGTKLALAIGTARRLEHDEAERVFGYCCNHSTIPYPDDQDRENLIEHAGSPAPGPQLTRTTSSTSSSTKGAPLSGTKKRWIDVYVREKVRVESADPSLMSLSAKLMALGHTLALARQNLEVLLGEDVRESSSEGSSPMEGGERGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0S9</accession>
    <name>G0S0S9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lactonohydrolase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0011110</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691631.1">
        <property type="nucleotide sequence ID" value="XM_006691568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0S9"/>
    <dbReference type="SMR" id="G0S0S9"/>
    <dbReference type="STRING" id="759272.G0S0S9"/>
    <dbReference type="GeneID" id="18255149"/>
    <dbReference type="KEGG" id="cthr:CTHT_0011110"/>
    <dbReference type="eggNOG" id="ENOG502RUNU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_371307_0_0_1"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052988">
        <property type="entry name" value="Oryzine_lactonohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064:SF2">
        <property type="entry name" value="SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409179" evidence="1">
        <location>
            <begin position="20"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="2">
        <location>
            <begin position="28"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="3">
        <location>
            <begin position="543"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS22639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="749" mass="79499" checksum="8F949EE673C123AA" modified="2011-10-19" version="1">MKLTLTAALATIAAHEVAGHALFQQLWPHGASCIRMPMSNSPITNVNSRDFVCNAGTRPVSGKCPVRAGGTVTVEMHQQPGDRSCNNEAIGGAHWGPVQVYLSKVPDATTADGASTGWFKIFSNSWSKKPGSRSGDDDNWGTRDLNACCGKMDVKIPADLQDGDYLLRAEALALHTAGQAGGAQFYISCYQITVSGGTGTASPSLVRFPGAYGANDPGIMINIHSALDNYIAPGPPVYAGGTTKVAGSGCAGCESTCKVGSSPSAQAPTFEPVGGGTAGVPEASSCQVQPYGQCGGQGYTGCTQCAYIDEETLSIIPVLFLSHWSIGSSSIKMALMMLKFLLTVAAGLTAAQDQSANGGHTLPRLATYVDQIRATVLDSVPPPSDDGAFQVFVPPGTTLQKLLDKPFHFYDPEFYTVTGPNPTLTLLNHTNGDLLFHEAPVWFPETDEMFFSQNAGAPAAGTGLNKSAILLKISLSSITPEITQKRNASGSVFIEVVDSDPQVINPNGGTNYKDQLLFLGEGQGEAITPAIYLMNPRPPYNTTVILNNFFGRQFNSLNDVSINPRNGDIYFTDPTYGYLQDFRPPPGLPKQVYRFSPDRGAVAAVADGFSQPNGIVFSPDGAYAYVTDTGMVQAFYGVILDNPATIYRFDVKEDGSFDNRKVFAYVSPGIPDGIHVDTNGNVYTGCGDGVQVFNRFGTLIGKIFIGHTAANFQFAGKGRMVILAGTELYYATLAAEGAFPGQLYQYTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0S142</accession>
    <name>G0S142_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="7">2.3.3.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0012270</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="7"/>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691744.1">
        <property type="nucleotide sequence ID" value="XM_006691681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S142"/>
    <dbReference type="STRING" id="759272.G0S142"/>
    <dbReference type="GeneID" id="18255265"/>
    <dbReference type="KEGG" id="cthr:CTHT_0012270"/>
    <dbReference type="eggNOG" id="KOG2367">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004588_3_0_1"/>
    <dbReference type="OMA" id="WPDKVID"/>
    <dbReference type="OrthoDB" id="418791at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07942">
        <property type="entry name" value="DRE_TIM_LeuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000045">
        <property type="entry name" value="2-isopropylmalate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.270:FF:000002">
        <property type="entry name" value="2-isopropylmalate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00572">
        <property type="entry name" value="LeuA_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005668">
        <property type="entry name" value="IPM_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054692">
        <property type="entry name" value="LeuA-like_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039371">
        <property type="entry name" value="LeuA_N_DRE-TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00970">
        <property type="entry name" value="leuA_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002991">
        <property type="entry name" value="PRK03739.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911:SF1">
        <property type="entry name" value="2-ISOPROPYLMALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22615">
        <property type="entry name" value="IPMS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="14">
        <location>
            <begin position="33"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS22752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="614" mass="68467" checksum="0F2E958A7E75FBAB" modified="2011-10-19" version="1">MPMLKDPSTKYKKFKPIHLPDRKWPDRTIDKAPRWLSTDLRDGNQSLVDPMNGDQKWKYFKMLCDLGYKEIEVSFPSASQTDFDFTRRLIETPGAVPDDVWLQVLSPCREDLIRRTIQALKGAKKAIVHIYLATSECFRRIVFNFTEEESIELASRCTALVRSLTKDDPEQQGTEWAFEFSPETFSDTDPDFVLRICEAVKKAWEPTVDNPIIFNLPATVEMSTPNVYADQVEYFCRNISEREKVCVSLHPHNDRGCAVAAAELAQMAGADRVEGCLFGNGERTGNVDLVTLALNLYTQGISPNIDFSDLNSVIKVVEECNKIEVHPRAPYGGSLVVCAFSGSHQDAIKKGFNLREKEGKAYHEHWQIPYLPLDPKDIGRDYQAVIRVNSQSGKGGAAWIIQQQLHLDLPRGLQVAFSKVVQDMAERKGRELLPTEITELFQHTYSLVQNARFQIVDYTITPDRSTSPAPPEPGKTQDTRNLRRVFDGVISIDGVEYKIRGRGNGPISSLANALRTVGIDLDVQDYKEHAVGRGRDVKAATYIECIAAGSSEKVWGVGLHEDVVQSSINALLSAASNFYKSGSPKIPVQAANGVNGSAKITDIINALEAKADEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G0S180</accession>
    <name>G0S180_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0012650</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-O/MCM21 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691782.1">
        <property type="nucleotide sequence ID" value="XM_006691719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S180"/>
    <dbReference type="STRING" id="759272.G0S180"/>
    <dbReference type="GeneID" id="18255303"/>
    <dbReference type="KEGG" id="cthr:CTHT_0012650"/>
    <dbReference type="eggNOG" id="ENOG502SCC4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042556_0_0_1"/>
    <dbReference type="OMA" id="NHHRVAF"/>
    <dbReference type="OrthoDB" id="10050372at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031511">
        <property type="term" value="C:Mis6-Sim4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018464">
        <property type="entry name" value="CENP-O"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14582:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14582">
        <property type="entry name" value="INNER KINETOCHORE SUBUNIT MAL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09496">
        <property type="entry name" value="CENP-O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS22790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="285" mass="32065" checksum="AA1B69D0492F69F3" modified="2011-10-19" version="1">MSTSLDDEIEALQARVNTLKSHLRIHTSTLLTAPSTLSLITSDRQLQSQSSLQQAHTQQCLYRACASITTFRTRDPDPRAVDSGSLLGLRIEVVSRGKFLRPYYVILNRPWRGHRHHLRVHRHTLPACVSVGGLAARYLPAPIGGDQDEDGEGEKGKKQDLARFARALRREVVRYHNRLGVVADLRRAAELAGKKNQEDDEKGEEQQRKRENMRLVDIRPADVEAKQIAIEWEDGRTGRLVMDDDGEIVKLVIVGENGRDHEAKRDLLGGARRVEDVVKRLAAIS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-03-16" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1B3</accession>
    <name>CMS1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName>Protein CMS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CSM1</name>
        <name type="ORF">CTHT_0012990</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in the regulation of DNA replication and cell cycle control.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CMS1 family.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EGS22823" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22823.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691815.1">
        <property type="nucleotide sequence ID" value="XM_006691752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1B3"/>
    <dbReference type="SMR" id="G0S1B3"/>
    <dbReference type="STRING" id="759272.G0S1B3"/>
    <dbReference type="GeneID" id="18255337"/>
    <dbReference type="KEGG" id="cthr:CTHT_0012990"/>
    <dbReference type="eggNOG" id="KOG3089">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057568_0_1_1"/>
    <dbReference type="OrthoDB" id="1929311at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032704">
        <property type="entry name" value="Cms1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24030">
        <property type="entry name" value="PROTEIN CMSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24030:SF0">
        <property type="entry name" value="PROTEIN CMSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14617">
        <property type="entry name" value="CMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000435817" description="Protein CMS1">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q07897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="251" mass="28695" checksum="E35534B440E71B91" modified="2016-03-16" version="2">MSLDNDINTKKRKLQDDEKPRKKRKHKRPTRDDDADLDVEAGLNRAFARMDGQLLADHLAQKTRRFGTELSSVELNDLYISAASIRDSSSFEKDRTLENLPSFLEKFAQEKEKLDEAPKKNGSPHTLIVAAAGLRAADLVRACRKFQKKGSPVAKLFAKHFKLEEQVAFLNKTRTGIAVGTPQRLIDLIEHGALSVENLRRIVVDASHIDQKKRNITDMRETMMPLAKLLARADFKERYTDEKKHIDLLFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1I2</accession>
    <name>G0S1I2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HPt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0013690</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="6 7 8" key="2">
        <citation type="journal article" date="2024" name="Commun. Biol." volume="7" first="814" last="814">
            <title>Structural and functional insights underlying recognition of histidine phosphotransfer protein in fungal phosphorelay systems.</title>
            <authorList>
                <person name="Paredes-Martinez F."/>
                <person name="Eixeres L."/>
                <person name="Zamora-Caballero S."/>
                <person name="Casino P."/>
            </authorList>
            <dbReference type="PubMed" id="38965424"/>
            <dbReference type="DOI" id="10.1038/s42003-024-06459-0"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 9-174</scope>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691884.1">
        <property type="nucleotide sequence ID" value="XM_006691821.1"/>
    </dbReference>
    <dbReference type="PDB" id="8PBW">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.40 A"/>
        <property type="chains" value="A/B/C/D=9-174"/>
    </dbReference>
    <dbReference type="PDB" id="8PDC">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.40 A"/>
        <property type="chains" value="B=9-174"/>
    </dbReference>
    <dbReference type="PDB" id="8RQG">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.40 A"/>
        <property type="chains" value="B=9-174"/>
    </dbReference>
    <dbReference type="PDB" id="8RQJ">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.40 A"/>
        <property type="chains" value="A/B=9-174"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1I2"/>
    <dbReference type="SMR" id="G0S1I2"/>
    <dbReference type="STRING" id="759272.G0S1I2"/>
    <dbReference type="GeneID" id="18255407"/>
    <dbReference type="KEGG" id="cthr:CTHT_0013690"/>
    <dbReference type="eggNOG" id="KOG4747">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085158_2_1_1"/>
    <dbReference type="OMA" id="QTFKKMD"/>
    <dbReference type="OrthoDB" id="1673781at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043424">
        <property type="term" value="F:protein histidine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="entry name" value="HPT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045871">
        <property type="entry name" value="AHP1-5/YPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28242">
        <property type="entry name" value="PHOSPHORELAY INTERMEDIATE PROTEIN YPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28242:SF52">
        <property type="entry name" value="PHOSPHORELAY INTERMEDIATE PROTEIN YPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="Histidine-containing phosphotransfer domain, HPT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6 7 8" id="KW-0002">3D-structure</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPt" evidence="3">
        <location>
            <begin position="66"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="1">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS22892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="8PBW"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="8PDC"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="8RQG"/>
        </source>
    </evidence>
    <sequence length="178" mass="19992" checksum="EFCFC86D41B610F6" modified="2011-10-19" version="1">MPGLIVDNADRAQDHNNNNTPRNSNYVVEEEEVSEEEEEAIMMPDFGDHVDTSIFGQILEMDEGDDHDFSAPLVLNFFEQAEETFQKMETALNNKDLPELSKLGHFLKGSSATLGFTKIRDSCQLIQQYGHGLNVDGSSEPDEGVCLKKIAEALASARVDTVALHKMMREFFEYDKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1M3</accession>
    <name>G0S1M3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0014110</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691925.1">
        <property type="nucleotide sequence ID" value="XM_006691862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1M3"/>
    <dbReference type="GeneID" id="18255449"/>
    <dbReference type="KEGG" id="cthr:CTHT_0014110"/>
    <dbReference type="HOGENOM" id="CLU_425775_0_0_1"/>
    <dbReference type="OrthoDB" id="3000060at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="643" mass="71644" checksum="1A2B2122C98BA23F" modified="2011-10-19" version="1">MLTALDGSSERQTWVSTLSVKELIEAADKYLSIHDQQGRLPKPLSAGSSGIWHQSKTNHEFKDYILTQIYYEANRALDRNTTLAILSFTPVTPEHDICIDLGKDSISTPDGQLKSAKVYLTAQEIRQAIQRAIDRHGEAFPNKDLNLRVILVTPSALTGGWVCRPWFMGSTTFSQEEDKERVMQVIAKSCGGAFADQLVRLFAEEDGEERSPLLPESERKETLEEHDAMRIYDLLEFRSSNMLLAHFIAKALGLPRRQEHSCRFWGEVNVDDNYYPKFAKALHDVGDFFCHPNLLPGENRNDNSPKFHRPPRWLSETIALTFAPETSREVVSTFIKTTVAPLFELIKATQKRLLTENEAVTRAGQAWLAAISTNLPGPIEHEPAQHDTTPEDNVQEVPHNTPAEHVVDDQSGEQVQPSALGHLDVFEAVDDGQSQEPIQPSTLGYLHAILKKAAHFVAQDAEKLGADLANSIPYEVGFYDPSDLFGESTDCKAGVILIRPIPKNPFENLGPSESGVSENNSREEMPETTEVNEVPQEDTKADIRVADNPSSRPQPQHQSVVIAHGSNTQRSVRFMNGQGSRSSEQYMSAAFQPSDQASQPWAHRDQSASEWEGTYAYNNGIDQTYAGEKVGFIMEVKAWGPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0S244</accession>
    <name>G0S244_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromatin modification-related protein EAF3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Chromatin modification-related protein eaf3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0015930</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in deacetylation of histones, chromatin assembly and chromosome segregation. May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MRG family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS23104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692096.1">
        <property type="nucleotide sequence ID" value="XM_006692033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S244"/>
    <dbReference type="STRING" id="759272.G0S244"/>
    <dbReference type="GeneID" id="18255631"/>
    <dbReference type="KEGG" id="cthr:CTHT_0015930"/>
    <dbReference type="eggNOG" id="KOG3001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_470898_0_0_1"/>
    <dbReference type="OrthoDB" id="124855at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.30:FF:000004">
        <property type="entry name" value="Putative Chromatin modification-related protein eaf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.30">
        <property type="entry name" value="MRG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008676">
        <property type="entry name" value="MRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038217">
        <property type="entry name" value="MRG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026541">
        <property type="entry name" value="MRG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880">
        <property type="entry name" value="MORTALITY FACTOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880:SF15">
        <property type="entry name" value="MSL COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05712">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51640">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MRG" evidence="14">
        <location>
            <begin position="393"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="226"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="14"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="292"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="351"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00057322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF05712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS23104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="579" mass="64068" checksum="DD708BE81F2D460C" modified="2011-10-19" version="1">MSSHASHMFRTGRASAPAPITPATISALSPPTSVAPVTTTRSGRVSEPTAKTLAAADLAPSQPSPSRNNTAVSVPAPDPTPAPARRSARARTGGTNNTHPSVSARNTRQQRLTIDDATAWGPIDRTYLHKEAAWAAAVACEDYLLWLPPPNADKQVLYVTRAGKKCFDDRYVMKSQVPGKGGKEEEEENGKGIKKEKVLTAGVAKEPAFADSTERFWRAVNEAIATLQKEEDKEDEEEDGEPVPSGSNDGNNNGRKHGGDSGLDDDAPAAKRCRVDHEDQEDDEDDDDLSVESGSNTASTSVYASNSVAVSRGSISQAAVTPETNMGIDLNSDGKSCLQESSREAKKQQDEQEDDREEDASGAQAPSGSWTSHHVRRADLEFDLDPEEYFDMKEDEETFHARPSIKLPMPDHLKAMLVDDWENVTKNQQLVPLPHPHPVNEILDDYLAFERPHRQEGSAAMDILEETVAGLREYFDKCLGRILLYRFERGQYHEMHALWQNPESKHKSPLDTYGAEHLSRLLVSLPELIAQTNMDQQSVNRLREELTKFTNWFARHVVKYFVSEYENPGQDYIEAARAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2K1</accession>
    <name>G0S2K1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Succinyl-CoA:3-ketoacid-coenzyme A transferase</fullName>
            <ecNumber evidence="3">2.8.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0017510</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate</text>
            <dbReference type="Rhea" id="RHEA:24564"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35973"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.8.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 3-oxoacid CoA-transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.5" evidence="3"/>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692253.1">
        <property type="nucleotide sequence ID" value="XM_006692190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2K1"/>
    <dbReference type="STRING" id="759272.G0S2K1"/>
    <dbReference type="GeneID" id="18255789"/>
    <dbReference type="KEGG" id="cthr:CTHT_0017510"/>
    <dbReference type="eggNOG" id="KOG3822">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019942_1_2_1"/>
    <dbReference type="OMA" id="VKTMGQI"/>
    <dbReference type="OrthoDB" id="1933379at2759"/>
    <dbReference type="UniPathway" id="UPA00929">
        <property type="reaction ID" value="UER00894"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008260">
        <property type="term" value="F:succinyl-CoA:3-oxo-acid CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046952">
        <property type="term" value="P:ketone body catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.10:FF:000001">
        <property type="entry name" value="Succinyl-coa:3-ketoacid-coenzyme a transferase subunit b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012792">
        <property type="entry name" value="3-oxoacid_CoA-transf_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014388">
        <property type="entry name" value="3-oxoacid_CoA-transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004164">
        <property type="entry name" value="CoA_transf_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02429">
        <property type="entry name" value="pcaI_scoA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707:SF23">
        <property type="entry name" value="SUCCINYL-COA:3-KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000858">
        <property type="entry name" value="SCOT-t"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01274">
        <property type="entry name" value="COA_TRANSF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="5-glutamyl coenzyme A thioester intermediate" evidence="4">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000858-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS22234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="523" mass="56344" checksum="93DD2F68686D54C7" modified="2011-10-19" version="1">MVSAGLCMRTLRAYAKYGNNHAALFARAFSVTARRPEINKIYPSAAEALKDMKPNTTLLCGGFGLCGVPDTLIDELLNKPEITGLTAVSNNAGTDNSGLGKLLKTKQIKKMIASYIGENKTFEQMYLKGEIELELTPQGTLAERCAAGGKGIPAFYTPAAFGTVVQTGELPLRNNPDGTPAEFSYPKDVKVFNGKPYLLEHAIEGDYAFVKAYKADRLGNCQFRLAAHNFNGAMGRNAKMTIVEAEHIVEPGEIPPEAVHLPGIYVQRVIKSTAPKNIEKYTWTLDPEEAAQDPKAAAALGSGETKAKRERIVRRAAKEFQNGMYANLGIGMPMLAPAFVAEGIEVMLQSENGILGLGPYPRKGEEDPDLINAGKETVTLKPGASVFGSEESFGMIRSGRINLTILGAMQVSANGDLANWMLPGKVKGFGGAMDLVSNPSKTKVVVTMEHTDKKGNPKIVKQCAFPLTGRQCVSRIITELGVFDVDFAQGLTLIEIADGVTVDEIRAKTEAPFKVADDLKPML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2R3</accession>
    <name>G0S2R3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">26S proteasome regulatory subunit RPN2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0018170</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the proteasome subunit S1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692315.1">
        <property type="nucleotide sequence ID" value="XM_006692252.1"/>
    </dbReference>
    <dbReference type="SMR" id="G0S2R3"/>
    <dbReference type="STRING" id="759272.G0S2R3"/>
    <dbReference type="GeneID" id="18255855"/>
    <dbReference type="KEGG" id="cthr:CTHT_0018170"/>
    <dbReference type="eggNOG" id="KOG2062">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002323_0_1_1"/>
    <dbReference type="OrthoDB" id="261572at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000017">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013897">
        <property type="entry name" value="Duc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048570">
        <property type="entry name" value="PSMD1_RPN2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040623">
        <property type="entry name" value="RPN2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08588">
        <property type="entry name" value="Duc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18004">
        <property type="entry name" value="RPN2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21505">
        <property type="entry name" value="RPN2_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit 1/RPN2 N-terminal" evidence="9">
        <location>
            <begin position="6"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit 1/RPN2 N-terminal" evidence="9">
        <location>
            <begin position="184"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome regulatory subunit RPN2 C-terminal" evidence="8">
        <location>
            <begin position="849"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="domain" description="Domain of unknown function at the cortex 1" evidence="7">
        <location>
            <begin position="1311"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="340"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="899"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1072"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1112"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1276"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1651"/>
            <end position="1680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="363"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="909"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="947"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1004"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1082"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1128"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1276"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1300"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1321"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1344"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1651"/>
            <end position="1663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1664"/>
            <end position="1680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS22296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1680" mass="184650" checksum="04F4752A46D415E0" modified="2011-10-19" version="1">MLNVITAPGVLAFLGDEPPELKVFALKTLNDDIDTIWTEVAAVLSQIEALYEDESFPERQLAALVLAKVYFHLQAYNESMTFALAAGPLFNLDAPGEFEETIIAKCIDQYIAVSSARHTPPKQIQTDIQLPAITTTFGSVIPENSALISPTTPFSQSTLPSKSLLSRTSDETAPESVAQFSDPAAWNALEAVVERLFERALNEGKYRQVVGIAIEAKNLDVLRRVIKRASADAGREGAPNPAEELMEYCLHVCMDIVQERGLRTEILRLILDLLNEIQNPDYFAIAKCVVYLDSDEEASALLKQLVAKGTQNATAIAYQIAFDLYDNGTQEFLNKVIKSLPSGEPPKKPEGESESAPLLENQDGSEEKEEKEEKEEEAKVYRNIRSILDGTTTIRLNLEFLYRNNHTDLNILNKVRDSLEARNSIFHTAVTFCNAFMNSGTTNDKFFRDNLDWLGKAVNWSKFTATAALGVIHRGNLSQSRKLLEPYLPKQGGVSNGSIFSQGGALYAYGLIHANHGADALEYLRSQFVAADEEVIQHGGALGLGIAGMATGDEQIYEELLKVLYADSALNGEAVGLAIGLIMLGTGSAKALEAMFTYAHETTHEKIIRGCALGMALIMYGRQEGADTLIEGLLNDPDPMLRYGGILTIAMAYCGTGSNKAIRKLLHMAVSDVNDDVRRIAVMSLGFILFRKPGSVPRMVELLAESYNPHVRYGSAMALGIACAGTGLDEAIDLLEPMIKDPSDFVRQGALIAHAMIMVQQNEVMNPKVGTIRKTLRKVVSDRHEDAMTKFGASLALGILDAGGRNCTIGLQTQTGNLNMLGIVGMAVFTHYWYWFPFTHFLSLSFVPTSIIALDHDLEMPTIKFYCAARASLFDYPPEDQVKAEEGPTLVTTAILSTTAQAKRRAQKKEKAARRESMDIDQPAAKTPSQTTAPAGGDKMEVDDDEEGKKKEEEKEKKEKEKEKEKEKEKEKEKEKEKEKEKEKEKEKEKEKEEEEEQQQQQQQKEEAKKKAEKEKVGFEIENMSRVLPGQLKYISFPAGRYKPVKKPTGGPLLLHDSTPSEPKSLIEEKLKKVTTERAPVAGQTTGSAASARAAATQQLLSNLSQRGAAGTIPGLNELFGITTPQRGEGRSGRAAGRGEGESGSGAAAAAGVLTAVDEDQEGDMEAEVPREFDRDDVIDWSLVPANTATRPVQALVRAPNAARWPSESETPDMADPSKYLLRVSCGPSYTPSTHTLINVNSPRPSSGYFELEEHRSRGDRYSIGLRFRLLDPDKAENSRRECDGKHMNGAGDETGNENGNHDPEDIKRAEGTPEQCEGWRVPDFKGKGKEICVSETPSPRTITPQHPTSQHHPSSSSSSSSQTPAVTSTSKEPRGIPAKSLLFGNSLPHPIRDRLPPGFGMALSLLTRWIDPGLEGDVYSDTPHLFGPVLSSFNTVYVGRGAVDLGAQGEELRAHGDEVRGVGVKGGQDVEREEGEDEAMRKMKRLDINHENGNHHNPDTEDGVGLAIQEGGDEEGLAWRRIIGCPDTASGRINWTLKDDGKEKWVWEFGRWYSIDFFNPYIDFGELAVRLPGIRIPVFRYWDGQGLRYVLLNRSTQNPYLVILFTLHLVEDINPGDGSLKPDAARALELEQAGLKVTGADEGEMIAQEEELELEPDDEGFAEEERIGGEIGKFEGEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2U0</accession>
    <name>G0S2U0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0018470</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692342.1">
        <property type="nucleotide sequence ID" value="XM_006692279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2U0"/>
    <dbReference type="GeneID" id="18255885"/>
    <dbReference type="KEGG" id="cthr:CTHT_0018470"/>
    <dbReference type="eggNOG" id="ENOG502S75S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054223_0_0_1"/>
    <dbReference type="OMA" id="DMYAKGQ"/>
    <dbReference type="OrthoDB" id="3534981at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58100">
        <property type="entry name" value="Bacterial hemolysins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="300"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="419" mass="46102" checksum="0247404FF0C674AE" modified="2011-10-19" version="1">MATEVEAPPPYDVGAPPSYESIIAKLDAKLKANPTIEGAKEAVESLTDVEKEFLASHTPESFKIEADEAMKLEFNKRALEAIKHAESHLQWSAEDCATSCKKAQQDFDALLSKLASISAVDGGEESKKLLDDLEALSRHDPLPLFIMARDFDEEVVPIALDKTIPKDTKVKKVELWIAKAEGLEKTAKDITVDFHRFLDDMRKYVGRFSAWSTKKEQAIDKEIDQLRGEVADLELKINNISKAMGIVGGATAGVAGIVIPAIGCLLALMEIPVSWPLIIGAIFAVGLAGAVSVASLAVAIEVLQERVKARKEKITELQNEKETIQQTREELKDLGKKLETDITHAVNLMLTAWDYCKNDAKDIKKYLESAEEDINLQVPPYLALKGLAKADGAYFVVNKYLTTFANCLADHRQPVLTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3G8</accession>
    <name>G0S3G8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative nucleoside:sodium symporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0020990</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692570.1">
        <property type="nucleotide sequence ID" value="XM_006692507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3G8"/>
    <dbReference type="STRING" id="759272.G0S3G8"/>
    <dbReference type="GeneID" id="18256137"/>
    <dbReference type="KEGG" id="cthr:CTHT_0020990"/>
    <dbReference type="eggNOG" id="KOG3747">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016813_1_1_1"/>
    <dbReference type="OMA" id="IVWHTVI"/>
    <dbReference type="OrthoDB" id="6075923at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008276">
        <property type="entry name" value="C_nuclsd_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011657">
        <property type="entry name" value="CNT_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002668">
        <property type="entry name" value="CNT_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590">
        <property type="entry name" value="SODIUM/NUCLEOSIDE COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 28 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07662">
        <property type="entry name" value="Nucleos_tra2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01773">
        <property type="entry name" value="Nucleos_tra2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="245"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="544"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter N-terminal" evidence="9">
        <location>
            <begin position="169"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside transporter/FeoB GTPase Gate" evidence="11">
        <location>
            <begin position="252"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter C-terminal" evidence="10">
        <location>
            <begin position="354"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS22551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="576" mass="62947" checksum="BE32CE82B1D4F862" modified="2011-10-19" version="1">MSAAVDEKKVPEAEPYVADPERQSDKVGSLNGKGASDKQGGSLFSSVSGILGRYWKKVAQLVTFMVFTAWWIYGLVKYRHTAGKGWLIPTLVYIGVLVRLITLYIPATLFLRPVRWVWIRTAVKVHDMIPAPFRKPAAALVTVAAFLIGTFVPEETGDNTRANRAVSVFGLIVMMVILTATSRNWRLIPWHTVIGGMLTQFIVAVFVLRTKAGYDMFKFISDMARQLLGFSGEGLAFLTSDSVPAVGWFLTAVIPAIIFFIALVQMLYYVGFLQWFIRKLATFFFWSLRVSGAEAVVAAATPFIGQGESAMLIRPFMNDLTMSEIHQIMTCGFATIAGSVLVAYIGMGLNAQALVSSCIMSIPATLAVSKMRYPEMEEPLTAGKVEVPKNEEDEHTVNALHAFTNGSWFGLKIGATIVACLLTVIAFVGLVNGLLGWWGGYWGLSGENTLSLELLLGYILYPFTWLLGVPKQDVRAVGVLIGRKIIINEYAAFSWLVNEEPYKSMLPRSKLIATYACCGFGNIGSLGIQIGVLSQIAPRRSGDVVKVAVSALFCGILSTLTSASIAGMLFTDDMLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3N6</accession>
    <name>G0S3N6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0021900</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692659.1">
        <property type="nucleotide sequence ID" value="XM_006692596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3N6"/>
    <dbReference type="GeneID" id="18256228"/>
    <dbReference type="KEGG" id="cthr:CTHT_0021900"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="OMA" id="MIVPIVC"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF18">
        <property type="entry name" value="NICOTINIC ACID TRANSPORTER TNA1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G03820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="28"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS20363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="489" mass="54526" checksum="1AE1B9CD20BE18AF" modified="2011-10-19" version="1">MSTSNEKQEVWVSQSEDRIDVEEADKVVGTAVTFADPYSHLDEKAILRKARQSHVLFQCSPFFISFHSLTYNWCLTAFFFPYAFFEVPSNLMLKKVRLSIWLPTIMVAWGIVMTLMGIVQNYAGLLSARIFLGVTEAGLFPGVAYYLTNWYRRDEIQLRQAMFFSAASVAGAFSGLLTFGIGKMDGIAGLHGWQWIFILEGGATVIVAILAFFTLYDFPETASFLTEEERVFVVHRLKYQGQSHDAAYAQVAQAEEFRWKYVWQAFTDWQVWLSIMVFWGVVCPIYGISLFLPTIIRELGYQSSQAQLMTVPIYITAAILAVFIAYCSDKSGRRSPFIIGPLLIMAAGFSVCLATDPTKHPKAVYAGVYVAVCATYPAFPGVVTWLSNNLSGSLKRSAGMALQIGIGNLGGAMASNFYRAKDAPRFMLGHGLELAFIGLGLLASTALLVGYTVENKKREKRIQRGALEAYSPEELSSMGDRAVTFRYKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G0S432</accession>
    <name>G0S432_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative ADP-ribosylation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0022370</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692704.1">
        <property type="nucleotide sequence ID" value="XM_006692641.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S432"/>
    <dbReference type="GeneID" id="18256275"/>
    <dbReference type="KEGG" id="cthr:CTHT_0022370"/>
    <dbReference type="eggNOG" id="KOG0073">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="F:actin filament binding"/>
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        <property type="term" value="F:GTP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="ARL2/3"/>
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        <property type="entry name" value="SAR1GTPBP"/>
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        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
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    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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            <begin position="168"/>
            <end position="799"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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            <dbReference type="Pfam" id="PF13254"/>
        </source>
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    <sequence length="1801" mass="195989" checksum="C64952D2364C48F8" modified="2011-10-19" version="1">MLSILRKARLKDKELRILMLGLDNAGKTTIVKKILGEDVSKVSPTLGFNIKTIDYEGYKLNIWDVGGQKTLRSYWRNYFEKTDALIWVVDGTDRLRIDDCREELHNLLQEERLSGASLLVFANKTDVRGCMTAEEILQMPAEGGFDVGLSTWRAAQRHSLDHAKLSMSDEVSDFLRTVERLKERREEEDEARSRELEERILQEKKERQARRAERARSISPQKSSPAATPSPTTHRIGIFPSASDGTSLASPGLESSGSPGQRSVPSAEPMDGTTDYSYSSSPTKENESPLDSDTKRNSVTVTSPSIAVPSARTTLAWQRRPTSQSSDRPKSRPLSMVAAENSARNSNPATESTIAPDQPMSRDQIAQALASKDPSWFRQTADPSRGSAAFRKNQVEDENTVELPSARTQLPGLARDVFTEPSKENQVPRPGTPATPGKPASPLPLGLAQRLDPPTGDAFGDADTPSANRLSTASTPSRTSPTRTSPTKGLGGFVESAMMKRADSVKRWSVNSPAGLHRADSSRSSISGLDNLQRSSTSKSRPTSMLRERDSAEGKEEGKEDGLSATGESGIQKEGQHKEETKKETPPTSPSKTMDPRRWSPNKNSWLEAALNKPESPKTKPAPATPSQPAWLVELNKAKAQKANATSSTNAPATESTANSALPKKPDAKPDGLVKPSSLIDKPELASFRGSLRKSSPSNDDSQTGSSVDAPTSSKSEYRSSVFKPPVPLPSQKTTDPIDELKSIAGSLRRTKTEKYVPQDEFKESLVKGKLALNVTGGPKKSERVDELKEAILKKKEEFKKAQQEGRGVSVAKEPSSASDNPLPEGIAKRLELQRTGTLRHSRTGSEAVASPTTSTNSNRFSFVSTAPKADTPAPSSEASTQRPGHIRTKSNVGSLAARFNPALASLIARGPPGVAGAAKGPEGSGNSGSADQMEAPSAPGPQLTHLTKNRARGPKRKAPTSVIKAMEQAEAKPQEKAAEPEKPAASAKATISPKPDRFTFPKADPLTAEKPKTGSDVIPLVDSSKKFPKEEPKLGEPVTLVGATPTRTRSKSIHEKIASLTALSQQSSKPAESSNDAQRSWGRSRSQTKVHEQVAALASLGQQNSKPAETNSDLQHTSSVKTRPRSQTKVQEQVAALAALTQSQTQKPAEPSTDTALQRSPTIRSRSHSRSPTKVIEQAAALAALNTTSSSSKSAEPSAEASTPLSPKKLDVKRMSQFFDQQSQMSPKPEPEPVKPKPASPIKDRFPSQSEKPGDAETESRPLFPIRRKSVAGQVLSSQPTEQKLAEDTEAKPQFHIRRKSVAGNVLSSQPTEQKPATVEAEKPVFHIRRKSVAAQSPTRAVSPPKPTVEDAPDVDDPPAKVSRPLPTPPPVISPTLTSPRVASPMRSPGKQPSEVAAMIEAFFGTERPRRKYTVDAAEVLIKRPISIAPVHTESVQFQRLLSDGKRFSPPSHHSRTLFEHEMYLCTHTFANNVGERLTEVYLWVGDGVSNDDINEGNMYAMHHAHKLRANYVTIHQGHETSEFIQALGGVVITRRGDSNRYDSLLPSMLCGRRYMGQIVFDEVDFSPLSLCSGFPYLITQNGKCYLWKGKGSDVEELSCARLVGMDLAVTGELIEVEEGSENEGFWAIFGGATRLPSADHWRLKPSYERYNSRLFVASSVEKQQIKEIAPFRQTDLSQENIYVLDAFFELYIIVGARSQHQYVAFRNALDFAQEYAILAAGMEDRPFVPVSTVVLEGIPRDCKSVFRKWEDKYCPTILNAPTSQPGALQPQKTGGNGGLKRARSLRTVPLTQALQALAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0S434</accession>
    <name>G0S434_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cellobiose dehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0022390</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692706.1">
        <property type="nucleotide sequence ID" value="XM_006692643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S434"/>
    <dbReference type="SMR" id="G0S434"/>
    <dbReference type="GeneID" id="18256277"/>
    <dbReference type="KEGG" id="cthr:CTHT_0022390"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011025_0_0_1"/>
    <dbReference type="OMA" id="IGYLQCA"/>
    <dbReference type="OrthoDB" id="413885at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1210:FF:000004">
        <property type="entry name" value="Cellobiose dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.410.10">
        <property type="entry name" value="Cholesterol Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053208">
        <property type="entry name" value="GMC_Oxidoreductase_CD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190:SF2">
        <property type="entry name" value="CELLOBIOSE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G17620)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408812" evidence="6">
        <location>
            <begin position="24"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="7">
        <location>
            <begin position="796"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS20410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="832" mass="89729" checksum="4A5EE47B81406CA6" modified="2011-10-19" version="1">MRTSSRLLGGLAAAASFLPLSLAQNNLPNTFTDPETGIIFNTWGLPNGAPQTQGGYTFGMALPEDAFSTDATEFIGYLQCAAKDAQGWCGVSLGGSMTNSLLIAAWPHEDTVYTSLRFATGYAMPDIYAGDAKITQISSSINSTHFTLIFRCENCLKWNHNGLSGGQSTTNNFMILGWVQAFPSPGNPTCPDQITLEQHDNGMGIWGAVLDGNVANPSYTAWAAQATKTVTGDCVTPTETGVPSVPVPTDAVFDYIVVGGGAGGLPIADRLSEAGKSVLLIEKGPASTGEHGGTMKPAWLEGTDLTRFDVPGLCNQIWKDSKGIACEDTDQMAGCVLGGGTAVNAGLWFKPYSLDWDYLFPTGWKSNDMKAAIQRVFSRIPGTDTPSMDGKRYYQQAFEVLSNALRSAGWTQVTANNAPDQKNRTFSNTPYMYSNGERGGPLATYLRSAKQRSNFKLWLGTSVRRVIREGGHITGVEVEPFLPGGYQGIVNVTKVTGRVILSAGTFGSAKILLRSGIGPQDQLEIVKSSEIDGPTMIDSSSWINLPVGYNLDDHLNTDTVITHPDVVFYDFYEAWSSPILEDKQKYLESRSGILAQAAPNIGPMFWEEIKGADGIVRQLQWTARVEGSFDTPNGHAITMSQYLGRGATSRGRMTITPSLTTVVSDVPYLKDPNDREAVIQGIINLQNALKNVANLTWTYPNASISAREYVENMVVSPSNRRSNHWVGTNKLGPDDGRHPAGGTAVVDLNTRVWGTDNLFVVDASIFPGVPTTNPSSYIVTVSEHAAQKILALPAPQPVQKWGQCGGRLWTGSNVCVEGTTCTVLNEWYSQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4R5</accession>
    <name>G0S4R5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="12">GPI ethanolamine phosphate transferase 3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0023260</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692790.1">
        <property type="nucleotide sequence ID" value="XM_006692727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4R5"/>
    <dbReference type="STRING" id="759272.G0S4R5"/>
    <dbReference type="GeneID" id="18256364"/>
    <dbReference type="KEGG" id="cthr:CTHT_0023260"/>
    <dbReference type="eggNOG" id="KOG2126">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004298_1_0_1"/>
    <dbReference type="OMA" id="YPSFDIF"/>
    <dbReference type="OrthoDB" id="272139at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16023">
        <property type="entry name" value="GPI_EPT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037675">
        <property type="entry name" value="PIG-O_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039524">
        <property type="entry name" value="PIGO/GPI13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071:SF1">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="517"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="580"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="607"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="637"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="670"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="696"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="740"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="774"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="813"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="876"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="963"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1004"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1036"/>
            <end position="1058"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS20494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1073" mass="117723" checksum="6A7EFEC6AEAD440D" modified="2011-10-19" version="1">MPPQKQVPKKAPSPLDSEYKAIAAQFDAAKRAKEAEDAKRAEAVEDINEREQRLARLNAARKAGYQSRWLWTTGFWLWMLFVHLVGLGYFISGFLLTRLVLEGKSSCEVSPTADSSTSDLLPAWKGKGTVNGGCWHPKTFERAVVIVIDALRYDFTVPANDSAAFHNAFPFLYETAVKEPKKAFLRPFIADPPTSTLQRLKGLTTGTLPTFVDIGNSFSGTAIDEDNLLMQLRNAGKRIVHLGDDTWESLFPGYFLGNLSKAYDSFNVWDLHTVDNGVMEHIFPLMEKKDQWDFLVGHCLGVDHAGHRYGPDHPEMTKKLRQMDKFIRDLAATIDDKTLLVVMGDHGMDGKGDHGGESDDEIEAALWMYSPKGIFGRTKPEYAMPPATAKIHPVNQIDLVPTLSLLLGIPIPFNNLGRPIEEAFAGAAGNAWANLAAAERVTAAGIKRYQSAYFNARGIQQSTEPGSAVDLWEKAEALVAAGGKKDWSAIWSAFVAYQETTLQQCKALWARFNVKNMVIGIAIMALGVITLLIYVSKDEDDDVIDDPELDLAEATLQLQGVKAGKADTDVVDVDCLEKRLTFSALLGALPCFFGGLLHSYVSGAGDWYRGSALAAFTSMATVLASMYDAQETLFRNIFPNTIWGWMAFVFTVSQSAGFASNSYTIWEDSILLFFITTFGVVSILAAFRLPSRADRYLSVYHSVVFIVLGRVASYSKLCREEQMPYCTSTYYASATSSTSAPWQLIIPFVVSVILPSIIKSYLQNTRSYEGLAPQWVGYVFRTGLFMCGLYWFLDAADSGGWLPGLPQQTLKSVTVYTAQMILGLALIAGTTAFVWAPPCVSVVTTANRSQPTKAQVAILGYGNAHGARYLLLPLNLLAACILLSKPMGGGALALMIWQVLSLLEILDLNQLSTSPIGPVMLAVLGTFHFFKTGHQAVLSTIQWDSAFIALFTVRYPWSPLLVTLNTFAGPILAATAVPLLVLWKAGPKKKGLLEAVSRRALGSFVAYYATESLATMAWAGHLRRHLMLYRVFNPRFMTAAALLLVVDLVGIVVSLAGVRVNTMAVSEVFGWAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4U3</accession>
    <name>G0S4U3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0023540</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692818.1">
        <property type="nucleotide sequence ID" value="XM_006692755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4U3"/>
    <dbReference type="STRING" id="759272.G0S4U3"/>
    <dbReference type="GeneID" id="18256392"/>
    <dbReference type="KEGG" id="cthr:CTHT_0023540"/>
    <dbReference type="eggNOG" id="ENOG502S4NJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048618_0_1_1"/>
    <dbReference type="OMA" id="RYQFPIP"/>
    <dbReference type="OrthoDB" id="5369511at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="254" mass="29142" checksum="6DC7109DFFB6534E" modified="2011-10-19" version="1">MDDLTSPSASDYSLDRTPTNTSNNTSGIVPGSNTRHYKLAAGKHPRTRRRPSNRDEFDGPHQFLKRPPPEYIALQERELPRLPTHLHIQEQDAVLNQVNERLSQCAYDFVAKYQFPIPLTHDMRPVERPQDREWTEWVYLLKRLATKRRIPARVLYNGQIKQFVTVLENSLEMKHAAKNQSRPLKDDRNILQLISAGIQVAKILKDAQAMEYLDRLYVNTERRIQERIAAEQAAAATASAPPPPAPAPAPMQYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G0S554</accession>
    <name>G0S554_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ribose-phosphate pyrophosphokinase 1</fullName>
            <ecNumber evidence="4">2.7.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Phosphoribosyl pyrophosphate synthase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CTHT_0032280</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="4"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693669.1">
        <property type="nucleotide sequence ID" value="XM_006693606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S554"/>
    <dbReference type="STRING" id="759272.G0S554"/>
    <dbReference type="GeneID" id="18257266"/>
    <dbReference type="KEGG" id="cthr:CTHT_0032280"/>
    <dbReference type="eggNOG" id="KOG1448">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033546_1_2_1"/>
    <dbReference type="OMA" id="CKMKKHR"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000017">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000043">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF57">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="18">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="237"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="239"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00077829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGS21373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="513" mass="55734" checksum="D6F26002C0468C15" modified="2011-10-19" version="1">MRGTLIFSGSSCPELTNKICQNLGMARAEAELSQFSNGETQVRILTSVREKDVFVVQSGSPKINDTIMELLIMISACKGGSANKITAVLPYFPYSRQSKKKSHRGAITARMLANLLDVAGVKHVITVDLHASQMQGFFKCPVDNLHAEPLIARWIRRNVPGWQEAVVVSKNAGGTKRVTSLADALKLNFGMVTTDKKRTHGYHSAQSMASSMITYLDGPDRQPVFDSVSNQMRHAISPESDNGAATTDNGDSLQNAPSETDAQSSDIPFNGNGNSRPQINGRNKPAPKRSQTLLSQSSTIDDLEDVDDVDGFEYNDRRAYEVTRGRLVQGHIVPDDFPSPVMSAAETSVAEEDPMTMSHASSFFAPQSHALGGSGDAGASSDEEDDILKDPKVEHEVTLVGDVKGRTVLIVDDMIDKPGSWIAAAETVVKRGKAKKVYCIATHGVFGGDCLEQMQACDCIDAIVVTNSYPIPEEKARNASKLVTLDISYLLAEAIRRNHYGESMSPLFQHLMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5K7</accession>
    <name>G0S5K7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cysteine-rich transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0033300</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CYSTM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693768.1">
        <property type="nucleotide sequence ID" value="XM_006693705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5K7"/>
    <dbReference type="GeneID" id="18257368"/>
    <dbReference type="KEGG" id="cthr:CTHT_0033300"/>
    <dbReference type="eggNOG" id="ENOG502T679">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152050_0_0_1"/>
    <dbReference type="OMA" id="DAGPYYP"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028144">
        <property type="entry name" value="CYSTM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12734">
        <property type="entry name" value="CYSTM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cysteine-rich transmembrane" evidence="5">
        <location>
            <begin position="87"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS21472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="121" mass="13044" checksum="082AC2B0BE59F853" modified="2011-10-19" version="1">MSGKEDQPPAYSQPAAPQPAYQQQPPQPPYNTYPGADPNAGAAQGYYAQNPQMAYGQQPPPAGYYYGQQQPPAGYYAQPGGPYPPQGYYPQQQQQQQKSGPGFLEGCLAAMACCCCLDILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0S678</accession>
    <name>G0S678_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Centromere-binding protein 1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0025780</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006692975.1"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG1318">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046871_1_1_1"/>
    <dbReference type="OMA" id="WKRVAQQ"/>
    <dbReference type="OrthoDB" id="71302at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11398">
        <property type="entry name" value="bHLHzip_scCBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047206">
        <property type="entry name" value="bHLHzip_scCBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="CENTROMERE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47787:SF1">
        <property type="entry name" value="CENTROMERE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="5">
        <location>
            <begin position="228"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="134"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="326"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="291"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="134"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="184"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="327"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS20742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="392" mass="42470" checksum="91FE5EC7FC10BCE5" modified="2011-10-19" version="1">MSTPVGVPHPELPADLATSPGQKRKRASDSSSPDTRRSKRGAPAATMATTESDANQAVQVAQAQAAQVTQTAQAAQSFLDNTVSIAQAAHEHVNVDDFSALAQATAADHSETTDATNATNTAAAALNMYPNLHVSQPTAEPFSSQPAQEAHQENTFNHSINQPAPAEPMPVAQPTSIPAPAAPAPANGVQQHPVQQQQPQAPPHPQTHPQYKPPNPKPAVGSEEWHKMRKDNHKEVERRRRETINEGINELAKIVPGCEKNKGSILQRAVAFIQQLKENEAQNIEKWTLEKLLTEQAIAELSQSNDKLKQECERLYRELDHWKSLAQSAGLGLPPQQQQQGQPQGQQQGQPQPEEQPQPAAQSQQTSQPQQQAQTQQAPAPSQPKEEQVASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2023-02-22" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>G0S688</accession>
    <name>G0S688_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0025880</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693048.1">
        <property type="nucleotide sequence ID" value="XM_006692985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S688"/>
    <dbReference type="GeneID" id="18256626"/>
    <dbReference type="KEGG" id="cthr:CTHT_0025880"/>
    <dbReference type="HOGENOM" id="CLU_2120819_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="114" mass="11946" checksum="9F7BF1370B933EA8" modified="2011-10-19" version="1">MLASTVNNDAVENMLMLLLCSGAKYICESFAVVAAMPEQALLLAATAASIVLMLQSHALALPAASERAAGSDRWISVLLLFGQPDLLASQPQPRLPNPGPEPKSCRMSLGPTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G0S690</accession>
    <name>G0S690_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0025900</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693050.1">
        <property type="nucleotide sequence ID" value="XM_006692987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S690"/>
    <dbReference type="STRING" id="759272.G0S690"/>
    <dbReference type="GeneID" id="18256628"/>
    <dbReference type="KEGG" id="cthr:CTHT_0025900"/>
    <dbReference type="eggNOG" id="ENOG502S0ES">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021647_0_0_1"/>
    <dbReference type="OMA" id="YASHAAH"/>
    <dbReference type="OrthoDB" id="5338458at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047092">
        <property type="entry name" value="AFUB_07903/YDR124W-like_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021264">
        <property type="entry name" value="AFUB_079030/YDR124W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102:SF1">
        <property type="entry name" value="YDR124W-LIKE HELICAL BUNDLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11001">
        <property type="entry name" value="AFUB_07903_YDR124W_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle" evidence="2">
        <location>
            <begin position="41"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="381"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="438"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="508"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS20754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="555" mass="61514" checksum="1EB5E147ECFDE84C" modified="2011-10-19" version="1">MNHHFGPQWPNPTKRRKRRFRRTDEDAEPAVIMKAMRSITIGNSEQVREYYVQRFTCLQQRLCREISKAFVKTIAPKKQANNPYTGGEEKRPDWWPGPWGPGEKERVRHKEPDHLWKKERIVLLTHILSLVTEPRERQHPDIRRVGVDTALLEKSTMDFVSSWFATNGPKNAHKKSILKELFRVAKAEERYKKNEIDGSTQIQVLADDMVMSYCPPEDDENEEDVEEVTTPPNLKGDPDQDHTPLVASCTMPLSKATAPTNSSLPPVSTTSSLSHTISSPLHGQSFLGDMHLRGHQYSSTSPMLATDLSTEQYAYPEAGNLTTVATATAGQPALQPEAPTSLQLQDMVHTHDPNSRRSSVACPAPEFGTSPSALYSPASWQQAQAQPHHHTATAVTSAPGSSGSTSLYYTTAATASQQTLPPPPPPPPPPHPNPLPLPHYQQQHLLPNPYASHAAHHQQAQTQAAAQQQQQQQQSQQQQQQTPSTITQYAAAATPTSTSAFESVLAPVHAHSPHSSHSPVHLPAHHHHPHHAHHPSFRGNLTLTMHTRTAPPQHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6R3</accession>
    <name>G0S6R3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zinc transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0035310</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions as a zinc transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693961.1">
        <property type="nucleotide sequence ID" value="XM_006693898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6R3"/>
    <dbReference type="STRING" id="759272.G0S6R3"/>
    <dbReference type="GeneID" id="18257569"/>
    <dbReference type="KEGG" id="cthr:CTHT_0035310"/>
    <dbReference type="eggNOG" id="KOG1484">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013430_11_3_1"/>
    <dbReference type="OMA" id="GAIHIRI"/>
    <dbReference type="OrthoDB" id="78669at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904257">
        <property type="term" value="P:zinc ion import into Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045316">
        <property type="entry name" value="Msc2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="2"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="42"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU369017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS21665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="288" mass="31960" checksum="330EFA93320FF008" modified="2011-10-19" version="1">MTEAFERFMEGRETKRLGELLVVSVLGLLVNLVGMKAFGHHHHGHGHGHSHSHSLNCSGHGHSHDHGNERPLILGHSDEKNGHNHGHSHSHSHSHSHSHSHSRSHGHSHENENMYGIYLHVLADTLGSLAVIVSTLLTWVWKWPGWDPLASFLIAILILLSALPLVKSSAKRLLLTIPPDIEYNLRETLSGITSLRGVVGYSVPKFWIDDRNSIGEGDDTRLLGVMHVVAARGADMEDVRDRVRNYMLERKVDVVVQVEREGDTSCWCGVGRSPLSQSHTRTGSTSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2023-02-22" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6T2</accession>
    <name>G0S6T2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0035500</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693980.1">
        <property type="nucleotide sequence ID" value="XM_006693917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6T2"/>
    <dbReference type="GeneID" id="18257588"/>
    <dbReference type="KEGG" id="cthr:CTHT_0035500"/>
    <dbReference type="HOGENOM" id="CLU_2277179_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="102" mass="11242" checksum="454E9AB7206726F6" modified="2011-10-19" version="1">MQSLDDIPSGIAVEDGLNEPTIDDFGSHGFSPGSSEDTVESAIAFKSWIVTNIQKGVSTPNEVNELLRAFGTYRCHLALCAEFVDPTTYVLYLLQRYYVFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6U9</accession>
    <name>G0S6U9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Translation initiation factor 4B-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0026950</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693153.1">
        <property type="nucleotide sequence ID" value="XM_006693090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6U9"/>
    <dbReference type="STRING" id="759272.G0S6U9"/>
    <dbReference type="GeneID" id="18256733"/>
    <dbReference type="KEGG" id="cthr:CTHT_0026950"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030044_0_1_1"/>
    <dbReference type="OMA" id="WTTVPNK"/>
    <dbReference type="OrthoDB" id="48651at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF11">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="75"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="164"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="220"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="243"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="289"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="346"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="387"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="460"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="490"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS20857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="526" mass="57599" checksum="4A75C11A2956DAF0" modified="2011-10-19" version="1">MAPKKKEVQKLSLGDFLNDTSFGGSWADEVEDTFGTGTQPLPPPERKTTYGTSNDRGFHSLRDNLPQKLPERPPFTAHLGNLSYEATSDAITEFFKDCKVVSVRIITDHEHNRPKGFAYAEFADVEGLKTALTRDGMVLEGRPIRVKVADPPRGGFSNRTEVARELDWSQRRGPLTDLPPPPPRGGERRRDFFNDDGKVRDFNNWERRGPLSPVPQPERSLSRDGSRSRNMDRRASPAAWGPGDRHEGSRPPRREFSDRPERQPTAAERDTNWRQSMRPDPPKQSSGESTQAPNSPAPSASQPATRPKLNLAPRTVSAENKDTTAPAPAASSKPNPFGGARPIDTAAREREIEERRAREKREAEERARQERLAREAAAKEAAEKAAAEAAAKANGAQEAATTEAKESPKESEATPSPAPAPAEHKIPIRSREPRDPPKSRATEVSNWRQPAPDRAPSRGGHSGPGPRRGGPRGPRNEGRGGRPNGNAAPQSPSVEQAPSTPIVDEEGWTTVPGKSRRGQSNRPIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7F6</accession>
    <name>G0S7F6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0027970</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-glutamate + NADP(+) + H2O = 2-oxoglutarate + NH4(+) + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11612"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.4.1.4"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 11">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693254.1">
        <property type="nucleotide sequence ID" value="XM_006693191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7F6"/>
    <dbReference type="STRING" id="759272.G0S7F6"/>
    <dbReference type="GeneID" id="18256835"/>
    <dbReference type="KEGG" id="cthr:CTHT_0027970"/>
    <dbReference type="eggNOG" id="KOG2250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025763_2_1_1"/>
    <dbReference type="OMA" id="MIMGWMM"/>
    <dbReference type="OrthoDB" id="6718861at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004354">
        <property type="term" value="F:glutamate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05313">
        <property type="entry name" value="NAD_bind_2_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.285.10:FF:000001">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.285.10:FF:000003">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000002">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000030">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.285.10">
        <property type="entry name" value="Glutamate Dehydrogenase, chain A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050724">
        <property type="entry name" value="Glu_Leu_Phe_Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006929">
        <property type="entry name" value="PRK09414.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43571">
        <property type="entry name" value="NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43571:SF1">
        <property type="entry name" value="NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="12">
        <location>
            <begin position="190"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="10">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS20958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="451" mass="49628" checksum="CF3DD951C0A6A401" modified="2011-10-19" version="1">MSNLPVEPEFEQAYKELALCLENSTLFEKYPQYRTALKVVSVPERVIQFRVVWEDDNGNVQVNRGYRVQFNSALGPYKGGLRLHPSVNLSILKFLGFEQIFKNALTGLMMGGGKGGSDFDPKGKSDNEIRRFCVAFMRELSRHIGADTDVPAGDIGVGGREIGYLFGAYRHYRNRFEGVLTGKGLDWGGSLIRPEATGYGLVYYVTHMLEYAGAGGWEGKRVAISGSGNVAQYAALKAIELGATVVSLSDSKGALIAVDDKGVTVEDIEAIMKLKERRRPLSEYEYKDNLRYIEGVRPWVHVGQVDIALPCATQNEVSKEEAEALVANGCKFIAEGSNMGCTLEAIEVFENERREKKGNAIWYAPGKAANCGGVAVSGLEMAQNSQRLAWTKEEVDEKLKNIMKNAFELGLKTAQEYVEASEGELPSLVAGSNIAGFLKVAQAMHEHGDWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7M4</accession>
    <name>G0S7M4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0036850</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694111.1">
        <property type="nucleotide sequence ID" value="XM_006694048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7M4"/>
    <dbReference type="STRING" id="759272.G0S7M4"/>
    <dbReference type="GeneID" id="18257723"/>
    <dbReference type="KEGG" id="cthr:CTHT_0036850"/>
    <dbReference type="eggNOG" id="KOG2274">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008920_1_1_1"/>
    <dbReference type="OMA" id="NPDQYTI"/>
    <dbReference type="OrthoDB" id="431626at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000373">
        <property type="entry name" value="Importin beta-5 subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056840">
        <property type="entry name" value="HEAT_IPO9_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF9">
        <property type="entry name" value="IMPORTIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25018">
        <property type="entry name" value="HEAT_IPO9_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="6">
        <location>
            <begin position="23"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="928"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="941"/>
            <end position="956"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS21815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1027" mass="113607" checksum="607011F938205C60" modified="2011-10-19" version="1">MDEHLARLLANTQDKNEGPRKQAELDLLHAQTNPEFPLSLARIGSHTAAPVEIRQSALSYLRNFIEKNWSPDGDHAPHIHIPDSTKEELRNIILELVLSPEDERKVKVAASVVVSKIASSDFPDQWPALLPSVLGVMPSGADPQLHGALRILQDIVEESLTDEQFFGAARDIIKACYDVALNENRKAQHRSLAVQVFRSCFDLMDIVKDDHKKEVKAFAEQVLSGWLPFLEQVIKSPLPPLDDSGSQPQSWYGPVALKVQVVKTLIKIRSVFKSLLLPRTPVFFTAVWEELLRLAPAYQALFIDSDAQSRLEDADGLPFTLDFLVLDLLDFLNQCMRAPPVQKQLDAEIAARGGAVHDTPWVLDLMKLLVAYSQITQEEEGLWDIDVSLFLAEETSVSSNYTARTACGDLLIKLAEWLDSRALEGLYAYTKALFTGQDSSWQKQEAALYLFNVVLNDFQDTDKQVPEQLLSAYLELVNYAINRPKDPMLRARGYLVAGNLSQHLKATLPLFDGVLNALTSDANELVRVSCIKAVEGFVNGGIPLERQSAVILAIQHFLETKDLSDLDDADDLLVTILETLRAAINMDMTVAIQPDSKALDLMFLVAKHGASSFHVTLIVCETFEDIASTFEERKDPALYTALCTKVLPSITGTFDVANMTQDSPLVMLAVDLLALLVKYGTEPLPQGFVAGILPKLNHLLMNSTEGEILRPGAEAVKFMLMHDHQQVFSWTDENGRSGLEVCLRIIDRLLTQGIEDNAASEVGGVAAELVEKAGHERLGPFLPQLLQAVATRLDSAQAAPFIQSLILVFARLSLVGAQDVINFLSDIQINGQVGLQVVLAKWLENSVNFAGYDEIRQNVIALSKIYSLNDNRVAQTMVKGDLIVNNSDRIMTRSRAKLNPDQYTIIPAPLKILKVLIEELLSASGAGAAPNMPAAATSNLADDDEDEDDEGWEDEPDDTLDLALGGTKQELMNWAEGGSSRQRDDETQAYLSDFFIRAARENVAGFQHWFNMLTPDEQNKLHQLAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G0S809</accession>
    <name>G0S809_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0037690</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
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        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
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            <authorList>
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                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <location>
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        <source>
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        </source>
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        <source>
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        </source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
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    </evidence>
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        <source>
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</entry>
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    <accession>G0S849</accession>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
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                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
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                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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    <dbReference type="GeneID" id="18256975"/>
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    <dbReference type="OMA" id="CGYCERH"/>
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    </dbReference>
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        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2016" name="Science" volume="354" first="1543" last="1543">
            <title>Comment on 'Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2'.</title>
            <authorList>
                <person name="Zhang Y."/>
                <person name="Justin N."/>
                <person name="Wilson J.R."/>
                <person name="Gamblin S.J."/>
            </authorList>
            <dbReference type="PubMed" id="28008037"/>
            <dbReference type="DOI" id="10.1126/science.aaf6236"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference evidence="13 14 15" key="3">
        <citation type="journal article" date="2015" name="Science" volume="350" first="aac4383" last="aac4383">
            <title>Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2.</title>
            <authorList>
                <person name="Jiao L."/>
                <person name="Liu X."/>
            </authorList>
            <dbReference type="PubMed" id="26472914"/>
            <dbReference type="DOI" id="10.1126/science.aac4383"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.27 ANGSTROMS) IN COMPLEX WITH EZH2 AND SUZ12</scope>
        <scope>FUNCTION</scope>
        <scope>DOMAIN</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <reference evidence="12 16 17" key="4">
        <citation type="journal article" date="2017" name="J. Biol. Chem." volume="292" first="13323" last="13332">
            <title>Polycomb repressive complex 2 in an autoinhibited state.</title>
            <authorList>
                <person name="Bratkowski M."/>
                <person name="Yang X."/>
                <person name="Liu X."/>
            </authorList>
            <dbReference type="PubMed" id="28607149"/>
            <dbReference type="DOI" id="10.1074/jbc.M117.787572"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.11 ANGSTROMS) IN COMPLEX WITH EZH2 AND SUZ12</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <reference evidence="18 19 20" key="5">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="9092" last="9092">
            <title>An evolutionarily conserved structural platform for PRC2 inhibition by a class of Ezh2 inhibitors.</title>
            <authorList>
                <person name="Bratkowski M."/>
                <person name="Yang X."/>
                <person name="Liu X."/>
            </authorList>
            <dbReference type="PubMed" id="29904056"/>
            <dbReference type="DOI" id="10.1038/s41598-018-27175-w"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.28 ANGSTROMS) IN COMPLEX WITH EZH2 AND SUZ12</scope>
        <scope>SUBUNIT</scope>
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    <comment type="function">
        <text evidence="4 5 6 7">Component of the of the Polycomb Repressive Complex 2 (PRC2), a histone H3 lysine methyltransferase responsible for generating mono-, di-, and tri-methylation on Lys27 (H3K27me1, H3K27me2 and H3K27me3) (PubMed:26472914, PubMed:29904056). The tri-methylated form is known to be critical in gene repression, and its proper placement is essential in defining repression patterns during development (PubMed:26472914, PubMed:28008037, PubMed:28607149, PubMed:29904056). EED is not a catalytic subunit but is required for the complex regulation of histone H3 lysine methylation by EZH2 (PubMed:26472914, PubMed:28008037, PubMed:28607149, PubMed:29904056).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 6 7">Component of the polycomb repressive complex 2 (PRC2) that consists of four core subunits icluding EZH2, EED, SUZ12, and RBBP4, among which EZH2 is the catalytic subunit and which minimally requires EED and SUZ12 for catalysis.</text>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
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    <comment type="similarity">
        <text evidence="10">Belongs to the WD repeat ESC family.</text>
    </comment>
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    <keyword id="KW-0002">3D-structure</keyword>
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    <sequence length="565" mass="61840" checksum="69F3E56E2901A4D1" modified="2011-10-19" version="1">MPASDSAEWELPRLRTSFIFQDDYKYLGDDGSVSQDLAEFFDVKFYPYSPPGAPPVFAATSKKHAVICRLTQTTDKDANPCEIIQLIRDDGNEANCASCWSKDPITDQPLLCIAGNEGNVKVYNVTEGKLYRTLVGHGGGINDLATSPANPYIIASASDDTTIRIWSLAPEHEKQPCVCILGGEGHSYDLLSVAFHDNGRYVLSAGHDQVINLWALPEFPNEHMEIPIVIYYPHFSSSEIHNNLVDCVAFYGDLILSRACHEDTIVLWRIEGFSSDDPIPGPLDAPTPTDMTKQTRSYFTPTVSPQSRPAMFTRLAQFHTPDCGVQFFMRFRMYHVPGKHPILAFANAKSKTFFWDLARFGEYARFMADLKEAQQSYNGRVVVVDQGQGISLAQAQQVHGPGVGVVMKPAWLVPKRVKKAPGAAGSGSGTAANGGHNNNNNNNNNNNNNNHETGSQRSFSATNNLSNSGRDKESASMVSASPDPDSPFGFSRETLQAWADMYDLSNPVGLIKAHRSLAIDGAFVGRQVGWSPEGEWCVVVGNGNRALIYQRWGKERGLGSGTPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8Q4</accession>
    <name>G0S8Q4_CHATD</name>
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        <name evidence="6" type="ORF">CTHT_0039960</name>
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    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988042">
        <property type="protein sequence ID" value="EGS20257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694406.1">
        <property type="nucleotide sequence ID" value="XM_006694343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8Q4"/>
    <dbReference type="GeneID" id="18258034"/>
    <dbReference type="KEGG" id="cthr:CTHT_0039960"/>
    <dbReference type="eggNOG" id="KOG3178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005533_5_2_1"/>
    <dbReference type="OMA" id="SCIAIRK"/>
    <dbReference type="OrthoDB" id="1535081at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
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        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF1">
        <property type="entry name" value="HYPOTHETICAL O-METHYLTRANSFERASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="232"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS20257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="401" mass="45202" checksum="37D2C2EA98452081" modified="2011-10-19" version="1">MTDFNHSDALAQAKALIPLLETFDGSLHQRKALLKHLNDLRSTFEHPSDIFARWQESMCTASALDIMLRLGAWKKIPDDGTPITAGELASGSNVDESVITRAMRILVTAGLVDEVDIDTYRRNALTSAFQADSYGSLASVGLYFVRGWGVIPSYSLTHATQDIFDPRRNPIVCFYGQEGKTFYEVLDGDPMLREMFDTSMYGLGTNLYQTEGLFPFEGMREQVMREPERVFVVDVGGGKGHVLREIRAMCGGDAWGRRLVLQDLPVVVDSLEKEDIEGFEVMEYDFHTEQPVKNAHIYFLRMILHNYYDPVCITILKNQARAMGPDSRLIVCEMLVPDKVEVGAPMDVHWMNFSMLMLGGKERRLAEFEDIFEQAGLEIAGVWRAKAGYCAMIEGRLRRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0S938</accession>
    <name>G0S938_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Casein kinase II subunit beta</fullName>
            <shortName evidence="5">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0044420</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer composed of two alpha chains, one beta chain and one beta' chain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694834.1">
        <property type="nucleotide sequence ID" value="XM_006694771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S938"/>
    <dbReference type="STRING" id="759272.G0S938"/>
    <dbReference type="GeneID" id="18258480"/>
    <dbReference type="KEGG" id="cthr:CTHT_0044420"/>
    <dbReference type="eggNOG" id="KOG3092">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034027_1_1_1"/>
    <dbReference type="OMA" id="QNGSPMA"/>
    <dbReference type="OrthoDB" id="2275560at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1820.10:FF:000004">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000001">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01101">
        <property type="entry name" value="CK2_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="60"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="289"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00045899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00062110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS19949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="354" mass="39714" checksum="817F76D8A76CCBAB" modified="2011-10-19" version="1">MSTSSGTPESWISSFCSLLGHEYFAEVSEEFIEDDFNLTGLQSQVAMYKEALEMILDVEPEEDEEDEDEEEQSEEDASDGQERRSHSGRRRGRRASDLSLIESSAEMLYGLIHQRFICSRAGIQQMSEKYELGHFGVCPRTMCNQTRTLPVGLSDIPGEDTVKLFCPSCLDVYVPPNSRFQTVDGAFFGRTFGALFLMTFPEYDLSRSGAEHAANLPRPQNGGEEPMLNGMYVRNIAPGLGRGKIYEPKIYGFKVSERSRAGPRMRWLRDKPDDMSVLDETRRFHEQQRLAAGGAESDSDDDVSMGTNGRPRRRPPGNLRLRQRQREQAQAQAQARNGTGSPMALETNGGESEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G0S943</accession>
    <name>G0S943_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0044480</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694839.1">
        <property type="nucleotide sequence ID" value="XM_006694776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S943"/>
    <dbReference type="GeneID" id="18258486"/>
    <dbReference type="KEGG" id="cthr:CTHT_0044480"/>
    <dbReference type="HOGENOM" id="CLU_315679_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14312:SF1">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14312">
        <property type="entry name" value="CREB/ATF BZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="619"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="731"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="568"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="622"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="663"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="737"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS19954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="925" mass="105980" checksum="D7D2F4B7B5493713" modified="2011-10-19" version="1">MSDRRDDISNHIDKEHLRKYFDRRFKEIANTRRSKWGRFTTSHDNATCMRSSSYTDVDGNRVVVDILPNGEAGRQRNLEIEGQNMRDARRIWSNRPGRKPKHGSAPGRLAEQWKDPEHWKSRYNYDPLPQSKSTDRLLIHSELATIPYKSPHAPPRHPNPPRRERRLLRPPQTMRILSSFALASSGSGSPYASVSASGAPTLSTSTSQSSVPFLSSGSGSRTLPGRVPPPEAYTSQSASQRFLFASDDEDDDKSDNEGAVCMKPSGRRVGTPPYFFPAPLATASTSSAATGSSSSVITSTQKPLKYEPLYVSPEEPKKFQPFEIPIVGHENSEVRLAFSDSKGNYDVSGGPLALLLLNAAAGVTPSSLLSSSQQQHINPRPRPQPRPILLPPSPPSHVPPVVHLRCNETIWLGVQAFLKSSGVKLDPEVYTLPSVRLGDLQAVRRWFNSEGRRVEKEGGEGSEKEMGMKERKMWVTKNWRAGDEGEWQDPVAGVLGECERRCELAIAEIMSVLREENEEIGAAGKMLWSMWEELERRDRLMSAPFDIPLLPATRRWERILERVRVARAREYEELTRMERAEEERLEIEREIERIRLAEEVRQQALMWLDPQARLMARMDGTWNDNDSNDNPSGIESANLDDNREDIDDNPLQPPLFIRAADVPSFQSPPEQQQQQQQQQQQQQQPPGPPSFGFGLDIVDRVRNENIQQWWEREQQRREYEQVQVINVPVEEEETSPALDSNTNPQIASNTNNFESGDQSRSERAERVPLRYQIALEYQWQLEEKENEEKKENELSHGGKELGSLGEYVLQETWEMREERKNQEEERCKKEELTRKEERDDVSQMMKSWDDERLEREAVAGVLVGWLTCRKEQYDKIAKLQGEQFARVVFWENEYTYRIPGGLVRWLRAKKFNFIAPHPYLDDRGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G0S945</accession>
    <name>G0S945_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Plasma membrane fusion protein PRM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0044500</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694841.1">
        <property type="nucleotide sequence ID" value="XM_006694778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S945"/>
    <dbReference type="GeneID" id="18258488"/>
    <dbReference type="KEGG" id="cthr:CTHT_0044500"/>
    <dbReference type="HOGENOM" id="CLU_1049738_0_0_1"/>
    <dbReference type="OrthoDB" id="4580061at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS19956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="28490" checksum="2E988FF113B3F8EC" modified="2011-10-19" version="1">MPNLPSHPSTAVAAAYSAVSSITATCTRDVFASSSSTGASNAANAPNVLASLLRSVHLNLQLNLNLITSTLGQSFSTGVGNLTTGHLPSLQCLHASLGAASHALKTAATTLKGLTSSGCQGAMGKINFILSTTPSTTSIGETWSRGIDAFRAWLTEPRDENHLLNLIWISLLVIEALMVVGVVLQAVWMSGRARRERAHGGHWTHYRTPSFDGRWSPIDTRFEKVDFESIDRALESAQWPVESDRWVDDGEMGKGRYRFSGQPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9L6</accession>
    <name>G0S9L6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0046330</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695012.1">
        <property type="nucleotide sequence ID" value="XM_006694949.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S9L6"/>
    <dbReference type="GeneID" id="18258671"/>
    <dbReference type="KEGG" id="cthr:CTHT_0046330"/>
    <dbReference type="eggNOG" id="KOG0298">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000796_0_0_1"/>
    <dbReference type="OMA" id="SMIPYIT"/>
    <dbReference type="OrthoDB" id="423221at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF26">
        <property type="entry name" value="FAMILY HELICASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="2195"/>
            <end position="2233"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="2248"/>
            <end position="2430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1571"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1602"/>
            <end position="1611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS20127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2440" mass="275473" checksum="88473F0A897FB0CD" modified="2011-10-19" version="1">MPPKDTQRRPLKKDGAPAPSARASRAQKRRLSENCDEDMDNPEQSIKRCRRAADDEIRSSPTLSDIPEDITMDDATAQESEENKDSDDDRPGKDRSRKQGLDKKLKPISDVSEMFEDMIQRCPPAHFEDRPVMLRVATVCSGTDAPIFALSHIRDALQAMGHGFCMDFEHVFSCEIEPFKQGFIRRNLPQCSLIFRDIVELATAARDGTATTAGGAPAKIPDGPLDIFFAGCSCVDYSNMNTNKPSGRVPSLDRHLKGEESRKPVPVRFDVAFFHDLSKSLEELAELSTAGESARTFFAAVKLIAERRPTIVILENVSGAPWSMYTDQIFPRIGYVARFVRLDSKNFYLPQTRQRGYLVAINCYREIPSPNEPPAEINVINANRIARAWTEWLQLCQRPASAPVTEFLRSPDDPSTILARADMESKPCTNSDWSLSSLRHIDARRRANLRHDDNPFSMKAMRGGQLIHMRPPDHSWRPVWKMAGPRILDLMDIVFAVSLKDGIDLGYKTAMIDVSQNVDRNEFCRLGRPKARNLGIVGCVTPSGLPIMTDEARPLTGTETLALQGLPAEELVLSTETQAQQRDLAGNAMSVPVVGAATYAAILAIAKVEPELFRQMTPEEAQRRHGLYVSRLGDQFVQGKDGGTMTTDVPWLIEIASQMRRVCFCPIRPSKIYVCRTCGVTACPSCSGNPPHNFGDDMADDLPNCSVERGKSRLKDCLPGTIMMFLPSDQVKDALRRTAGGIFRDVALEVLGGNDSELPFYYFDDIKVTESITICYKAVNSIARLVLCPATKTACWYIYIAPWHSQLGDLARHFDVNQPIARGQVDTNILVPTWSVWIPGRVELRLELQQNKHGEVTIGSLDYVNSEAAHEHPDLPAWKATVESKIRGTYTHSPQCGTAGRALHVKQPQHGDSKVFLMWESLRLEVPEKDHFVWTEMPRRIESHEYREVLLCADTSKPFTLQPEQGVMKVYWNGHWSNVTVHGPLTPATPLPELAVVFWGPTAELQQRKCHSPESPESPIVRMAPFAGIQAPLRRFPASKAYLSKFRQEHTDSDFYVVPAAGRDAFLRRFAFLSKEIRQATMPEDGASFPHLHMRWISIDACDVCSVSPPKAVLLCKEEPRRDATGKNRDARLKKLLVEDPEDAEKFEKQLQELPNAVTVAVRLSPSLPNNGQIEELLDIRILLQPKTLASRALAYIRQGHPSTTRGADVINDEYKASFLTELDYAFFSTRPDFAPFRNSVKPCGDHNTHGIDLTNNTWKMPAGEPPRFLRRVGRSRQVVQHRLRPSQRDAVKWMIQRERIPLNFIKREIEEEVVQPLNLRVAGKAEWTTRFPYSSRGGVVAHEIGYGKTVVTLALVDYMHEYDTTISVEERIREVDGAWRKELGDNVFQLFGSDAEGLRAESFFHHLSATLVIVPRHITDQWAKEIDKFLGLSTRNGSVLVIKTSQAFHGKYTLQELNRAQIIIVSSSVFGPSFREKLEEVSGCGVEFAKGLSGRALDLWYREALRNHRILTAFYLAARRSSSDEEKLISLIEKSLLPQLNRSEMEKLDDILDKQVQGIDRNYYKSRLRDNTVEPKQQKNTGATLKFGHGTAEGRGRQGRDAQSTKSPVGNVWSPTSLHACSFARIVWDECSYDDDKDSYIPVFVANAVANSKWLLSGTPKLFDLGAVCRLANAFGVHLARPEPRLMPGLPAITEGPKPEQLTPSEQFYAYSSSVKSSSLAVERHNQGHSFVSQYFRCNLLEDEEEIEFEETVVPIAMAPVTAIRYYLLAQEVLDAGEDYSLLPEHARSQIKLKGSDLATRDVKAQARMLLGLMACGLGQNENIQSIDDVKRDLDQRVAGCSRQFKMLFDKQMFLWSWINLLHDLESSAAWSDPVKDSLEKVEFICSRLTEALLGNKRVTRFDEGDLYPHEAQLIAPHVPGDDPEGNRTIYPEWEDCLNQDWAARFRKSSALYTWIDFFDISDCDINKLHEEQLRSLAKDILYLRCKIDPDVRPLERQPGGAKEAMMKQRWLENALEDTTIRRIAKENAATIDMRVEKDLSVITQLSKAELVSFIKSCQDAKSRQMERDAANADRFDQCSTRELRDLCLEHNLKVPGTTGEMKSVLKQHLMGTLGREHYRDGRAPVNRYRSFQAAMACENRSLSHQISRANEELKQTLVHLTKTIEDLRAAKLEGGFVPGYDSLTKGDNDTKTCAKCRRPLPDDLSFIVVACGHFLCEDCKKSAGFYCPVNDCLAFVHERPVLSCSEIRRLYTQQEEAYETRAAAVVDLVKHRIPRDEFVVVFAQYGLFVEALDTAFRNSGLRYTNLSKVNDENIAAKLEDFKNGNAGQILLLDIDNETSAGSNLTNANHVIFANPFVHHDEEHQSRTVRQARGRCVRIGQTRKVHVYHFMAPGTIEEQTLRHYSEYSKDVSGFFEKWELVPWWMDRMEKRTERSCGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9U3</accession>
    <name>G0S9U3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0047190</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
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    </dbReference>
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    <dbReference type="OrthoDB" id="445341at2759"/>
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    </dbReference>
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        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ALKBH3"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212:SF5">
        <property type="entry name" value="ISOCHORISMATASE FAMILY PROTEIN FAMILY (AFU_ORTHOLOGUE AFUA_3G14500)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="656"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="291"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="702"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="329"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
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        <location>
            <begin position="445"/>
            <end position="461"/>
        </location>
    </feature>
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        <location>
            <begin position="503"/>
            <end position="517"/>
        </location>
    </feature>
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        <location>
            <begin position="531"/>
            <end position="553"/>
        </location>
    </feature>
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        <location>
            <begin position="554"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="706"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS20204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1061" mass="115689" checksum="7ED0475CAB87A4D2" modified="2011-10-19" version="1">MGPSFPFPASMIPIVPTRKGLLIIDLQNDFISPDGPLYTQQPEGWVNRVLDLVKAFRDTQSGDVIWVRSEFRKNRPLVDGDRVIQIITSLEALHEAAETSRGRSPVSVVHDIAITEKDKEAFLTPEVEIPEGEEPKTPVVVPGTEGAQFAPEVQATIDRRDIIFTKTHYSAFAEGPLLQTLRRRFVTTFYVCGALTNVSIYATALDAAQHGFQMTIVDDCCGYRDAGRHRAAVNKLVQVTGSDVVTYAELIEQFRPPAPPTLSSGLSPSISNIEIGSSSAALSGVPADAIPKVSSSEAESSELRPKGQLPPPKLRPGELEPQAASPPHAPEEDRDERKQSDDQPWPQPASRSPQPNLLEDRVALRPLDDQGAVIKDTSSARPADANRVTCDDESTSPRDSPRQKLAESARSTENHLQNGDATARRHPESESPKGPTQAPGAANTKTEKPRVRLQQRGEKTRIVICQKFDVDDDKKTSSTPSASKPDTDASTTVHADRIDQESSSKSLDPSSIESVTRATAELKLSDLTTLPPEITSTPSSKTTPTHSQQPSPTMADQPTVTSSEPLCEGDTTIFYNVLPSELADIAFGKLLEEVSWAGMSHMGGEVPRRVAVQGEVAPDGSMPVYRHPNDESPPLLPFTPTVRKIKEVAEKIVGHPLNHVLIQHYRNGNDYISEHSDKTLDIVQGTYVTNVSLGAQRTMVFRTKRPLKDKDKDGKPDDDHDNNSNDEKKAPAGSKRQIQRAPLPHNSLMRMGLKTNERWLHAIRQDKRADRDKSPAELAYSGARISLTFRHIGTYIDASQTLIWGQGATGKTREEAKPVKNGLTDEAVAMLKVFGTENHSSEFDWQEWYGKGFDVLHMGVPKRFCVGAKDGAVGNASVLLALGELGVSCAKGSVEGVCRFEENDVSRAVVEGVGTVLRYLDAVYGKGRRYDQLLPGEVAKRFTLLAKAEGLAVRWKEVGSMLGKGGVSKDVVRALMKKELEEWEGVAGEAVSSEFGEGLYICGGVQASPADFGLWPVLHDMVRACGGDEGLLGGESGFLRKYYVAFRGRGSAAKALELWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9X1</accession>
    <name>G0S9X1_CHATD</name>
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        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">CTHT_0047480</name>
    </gene>
    <organism evidence="3">
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        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006695054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9X1"/>
    <dbReference type="GeneID" id="18258786"/>
    <dbReference type="KEGG" id="cthr:CTHT_0047480"/>
    <dbReference type="eggNOG" id="ENOG502SE0Y">
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    </dbReference>
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    <dbReference type="OMA" id="TLYLHDM"/>
    <dbReference type="OrthoDB" id="2445945at2759"/>
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    </dbReference>
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        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
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    </dbReference>
    <dbReference type="Pfam" id="PF00583">
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="2"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="171" mass="18953" checksum="1B079738BD04C35D" modified="2011-10-19" version="1">MAIWKPINPTTSDVDELVRVGQTVHDPSLDEGADVFLERVQLFPQGCMVLVEDGHIVGYAISHPILRDCPPALNTKLGAVPTNADEYYIHDIAILPEFRGKGHAAECIDKILRVADQYPTTSLISVYGTASFWGRYGFAPVPLLEGHLAKKLASYGEDAQYLRRQNKECSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9Z6</accession>
    <name>G0S9Z6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0040450</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006694390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9Z6"/>
    <dbReference type="GeneID" id="18258083"/>
    <dbReference type="KEGG" id="cthr:CTHT_0040450"/>
    <dbReference type="eggNOG" id="ENOG502RJV8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_672688_0_0_1"/>
    <dbReference type="OrthoDB" id="5235700at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="409" mass="43318" checksum="47D00B9C258DD98E" modified="2011-10-19" version="1">MATLDEKIPENQSLGSASAPPAAPSRAASATGAAADQPRFAPGFLGVTETKGFSPCDSSPATRNGSGSCSDRDQLKRAGHNLSQRATITGKRRAVVVELKRSDEGLNKLAGLGARLGPESVHVAPTSTAIPLPFNINKFPFIRPPPPLPFTPPRLDPMPGPPLSSSELSSLVDRHPNDLASAPPTFGSDLLSMPNPDYAEGIDDAEVKSIASGVSEGSSTQQQQQQQQGSGSGVPTKRRSYNKTAPIGFSKEEVLGVWTSALTSGFKPVAGNGSEIEFVTRTVYAESLAQGNRIPGSEVTLSGNNALGENDSSSGKESGDREKMGEKQQAQSLSAQQTEQQEQDHHQQQEIEVQGEIISVLDGNGHGWTRHTRVYGGGPCLACRLARERDPTIPGGFYGENVPVEERRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G0SA75</accession>
    <name>G0SA75_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0041260</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degradation via the proteasome. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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    <dbReference type="eggNOG" id="KOG0001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010412_7_0_1"/>
    <dbReference type="OMA" id="VHENTRR"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="Polyubiquitin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ubiquitin"/>
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        <property type="entry name" value="UBIQUITIN"/>
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    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
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            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
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            <begin position="77"/>
            <end position="152"/>
        </location>
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            <end position="304"/>
        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00054839"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS19647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
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</entry>
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    <accession>G0SAH8</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
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        <name type="synonym">Thermochaetoides thermophila</name>
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            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
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                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EGS19750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="759272.G0SAH8"/>
    <dbReference type="GeneID" id="18258272"/>
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    <dbReference type="eggNOG" id="ENOG502SRF0">
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="355" mass="36652" checksum="D3B48341BEA72B76" modified="2011-10-19" version="1">MPPPPPLLLTKRVTAFLRANLSPPIIHTAMLTTPSGSLLAHAGDMPASALRRQCAVAAQLWAIQSQARAARAAAEHHQQQPGESADTGAEDLTAVATPGATTTVKRRKDRPPVVTVQLDTGAVFVIRRLRCGMLFICMGGSEGSKSNPNDNTAGQRTPTPSHLPHGQQLTSPSPRTVPHSSQALADPLATTDLPPPALQLPHHPAPTSHSHKQKPSASPLLPGQKTPTPSHPHPQPPRTPPSGTGQPTSGPGSPHPSESAISIASVASNETTATCSTITGSNSTVSLMRRQVEELARWLDEKLAGLCVPEEGIGVAGTGVSGMGMGMGQVGYHMGAGGMGMSYSGQGQGQVYGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAL4</accession>
    <name>G0SAL4_CHATD</name>
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        <recommendedName>
            <fullName evidence="3">CID domain-containing protein</fullName>
        </recommendedName>
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    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ENTH_VHS"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140">
        <property type="entry name" value="RNA PROCESSING PROTEIN LD23810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140:SF0">
        <property type="entry name" value="U2 SNRNP-ASSOCIATED SURP MOTIF-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="465"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="314"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="748"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="66"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="436"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="771"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="789"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS19786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="821" mass="90144" checksum="0E43484102B25EE0" modified="2011-10-19" version="1">MSSSKKIAEFPDVEAKLQKPIKPSAFERQKAEAEAKRRREEAETAAVYEDFVKSFARDDDDDFLQSKPTSSRFNSGPSERPLPFSSQAPFGGATGKRHFSVPSGGALKSGPGTLGPIPPSFSKKRSYDGFQRDQEEGKAGRLGFDDKDSGSLPVSKAFDASDDEGETPTVTDRAEEKATSKPTLRLANLPPGTSPAVIKALIPSNLTVENIKINPPPGPGGTDRKSLTAIVTLSKETPASDIDNAVSALQNRYLGFGYFLSLHRHLSSAALSSGLPALSSSGAVSHPFGAKKTEDGPRRTGAHGRFAPPPSYGSPLGGPLNRSGILHVPVRPPRDIKQLRMIHKVIEAVLEHGPEFEALLMSRPDVQRDEKWAWIWDARSEGGVWYRWRLWEIVTSGQHKKGRPEFVPLFEGSHAWKAPDRRLAFEYTTDVSEFVSDSDYDSSEDDDFEDDPARQDNNEKEDTFLNPIEKFKLTHMLARLPTTLSKIRKGDIARVTAFAITHASRGADEIVDMIISNIEHPFAYTSANPNYKPGGKDKEAKDESSRDASPSPDNKDKEKTSSSSDGPDLSAPRLLGLYVISDILSSSATSGIRHAWRYRQLFETALRKRKTFELLGSMPEKLNWGRLRAEKWKRSVSLVLNLWEGWCVFPVETHEHFVSSFENPPLPSKKEGPADAGTGAEKRPGGRWKIVEAAPSTGLSFLPVSTKPDVDETGTEEEEIPGLAPEDGEEIDPVRLQYLAELDDAFDDLDLDGEPEDVENLHITPAGGPEPEPKESDEAPSKPEAKSITGFQMLSSSKFGPPRKRMRAMDMFADSDSDGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0SB21</accession>
    <name>G0SB21_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative suppressor of glycerol defect protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0048600</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695223.1">
        <property type="nucleotide sequence ID" value="XM_006695160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SB21"/>
    <dbReference type="STRING" id="759272.G0SB21"/>
    <dbReference type="GeneID" id="18258898"/>
    <dbReference type="KEGG" id="cthr:CTHT_0048600"/>
    <dbReference type="eggNOG" id="KOG2141">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006786_2_1_1"/>
    <dbReference type="OMA" id="FMVDILN"/>
    <dbReference type="OrthoDB" id="361797at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000050">
        <property type="entry name" value="Nuclear protein (Sgd1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF4">
        <property type="entry name" value="NUCLEOLAR MIF4G DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MI" evidence="5">
        <location>
            <begin position="738"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="255"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="693"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="110"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="281"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="314"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="693"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="707"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS19401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="968" mass="108920" checksum="30016595E9085F3C" modified="2011-10-19" version="1">MAPPKARGPKKPTLPSSLLKELGVGDPANRGQKRKRGSVQVTSRKERRKLERQQAKAQRAGAAVRNQNAVAPPSIQKAGKPQKTLATGKDAQTNGKPPKSILKKGRPVLDEEDEDLSGFEDEFDEEEEGDGELSDDVLDEGSEEGEEDEGSEEEGSELRSDEDIGEDLGLDDDDDFGEGDGEDLEDDDVEGEAKAPKRKIPKALEDAIKQDDKQIRELERKLGIKNRKKLPKVFKDDGLDELLEDLDNFLDDMTDRQRQKAEEQEWLAQKRRKAEAAAAKKAKEKENKAAKEDKDGKKTKEKAARESKKRPEPESDEEEDLDEEDMDDLDEDVDEDMDKDIEGFDEDDMDGFDEEAEEDEDMEDEDESQGDDFEGFSEDDNADEPPAKRVRENPYVPPTTGQVAKYVPPSLRKETSSDSELASRVRRQTQGLVNRITESNMLAILGEIEKLYREYPRQHVTSSLVDLLLIQVCDQTSLPDSLLILTAGFATAAYMVIGTDFGGQLIQEVVERFDKYYEEAKKIAEERPDVPKQTSNLITFVAQIYTFQLIGPNLVFDYIRMLLESLSELNAELLLRIVRICGPALRQDDPMALKDIVALIPPAVQKAGGQKNLTVRTKFMIDTITDLKNNKMKAGVGATAIIVEHTTRIKKILSQLKSRRLKATEPMGIGLKDIREADKQGKWWLVGASWAGRSKDDKKPKTANKDDESDDDDSIIVDDVEDGPDLAELAREQGMNTEVRRAIFVAIMSAMDYQDAYLRIMKLRLNKERQREVPNVIIRCVGAEQHYNPYYTLVAKHLCAQQREVRWSFQASLWRLFGRMGENEFGDEEDEPVEDEAGDADLDMRRLVNTAKMYGSLLAANSLPITMLKRLNLVYPQRKTRDFVELMLVTALLELQQKSEKPEEAIVKVFGAVEATPDLAKGLQYFLKKVVRKSDLAGGKEKTKLLKEACKMAEAAVETAMARAEELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G0SB77</accession>
    <name>G0SB77_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0049180</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695279.1">
        <property type="nucleotide sequence ID" value="XM_006695216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SB77"/>
    <dbReference type="GeneID" id="18258956"/>
    <dbReference type="KEGG" id="cthr:CTHT_0049180"/>
    <dbReference type="eggNOG" id="ENOG502SYFQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_337703_0_0_1"/>
    <dbReference type="OrthoDB" id="3540583at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22744">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409432" evidence="2">
        <location>
            <begin position="19"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="682"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="815"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="510"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="641"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="682"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="695"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS19457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="843" mass="93829" checksum="76010437AE7784A4" modified="2011-10-19" version="1">MQLKTLLTIFAAAAIASAAALPEPEPVAEPAAAALRKWTAEGGCKIDWSRRCNAQCKGEAINKGYKCKDVDSDIIGGPTNCVPGWRNDNLEELSMLLWVRELDTIKRTRPLLDPKAFPVKTVGIYHVNWQEALGEKAIKPKKASKTTAAEVIDLTDLDDDDDDNNNTCNSSNKVTSPTSLMQRNWHGTSSAEEVFPREWITALANVPIDLETALTGSYWAGFYTQWRNDQQKNKQSHGGRPVPQLLFKGFPMMEDVVFFKHSNFWTDPDGIYHADSGCCYWLSLALILYGNPRAWLRVKAEHLNFLEQVFSDSSHPRYTYYTRMNQHKMQTVAPTGTVDASLFEMLHTPGCWVSDEMCNMTADIYNVFIVLYKYDSPNKDNEKWKNKVYDMKAFGSYNNRHIFLCFTNENHFQPMVPNDYLAHEFKLPRITLESTKKYKMETNAKARKNVEDGPKHYMRNWQFTPLFHMPSFTIEHLSRAAGVPMAPKSHTAFSKVPQPTPPASERARRFAASSVSSSRSSKPLPLSLHGKHPSPDLESPPAKRLKTVMGSRLVTAPGYIPGFTEQVRPQTSTPRSRPQESDRSQTSPSKHHDSVLSPTTRPVHPGSGSQLQEVESPTPTGKLVQVEAQETNQANKRKETATSSKTATSSNQTMTGKATATGKVITATATDKIITSGNAITTTAGKATPTPKATNSGQATTGSKASPSGKTTAPGNKKTVQRSKTNDPPGAEWKSATKSLLRRIRLDSLQVLCFNHGLGKMGGEIEGWTKEQCVQALLNLQESGTKVQIRMVKDGRRLVPDLRWKWLDPQLAWGEGDEYEKEVEDDELESGGEDDHEPPSEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>G0SB90</accession>
    <name>G0SB90_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0049310</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695292.1">
        <property type="nucleotide sequence ID" value="XM_006695229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SB90"/>
    <dbReference type="GeneID" id="18258969"/>
    <dbReference type="KEGG" id="cthr:CTHT_0049310"/>
    <dbReference type="HOGENOM" id="CLU_841978_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="330" mass="38102" checksum="33200DAB608D18AA" modified="2011-10-19" version="1">MSQTANNQTDIDRAPNPSNQTNSQSNPVTSQQTTHFNTNSQSQPPQELKDLRDLHFALHEKVQEVSKKLDDSIRDIFHFLVEILGRANDTNTMVKNLEYALDGSNSLNNSETIKVLKETHESARALVVRIQAAHNFSQSLQFQYAQHYYRPGWRIGIRWLDEFFIPALDATKAVRAWLQEGVKSAEEMESQGGTPTLTSEQKRFCEDFERLCIEYWRPFFDQEESLRQALSSLKTHPCHRRLSGMECDCQQMIEFRDAKFAWEARVRILQRELDAMWWKLQSLCLPAPAIPQTPGQPMEMSPQQPQPQPQRQPSPADGKGQFWRDLNPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBB3</accession>
    <name>G0SBB3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rieske domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0049610</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695315.1">
        <property type="nucleotide sequence ID" value="XM_006695252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBB3"/>
    <dbReference type="STRING" id="759272.G0SBB3"/>
    <dbReference type="GeneID" id="18258999"/>
    <dbReference type="KEGG" id="cthr:CTHT_0049610"/>
    <dbReference type="eggNOG" id="ENOG502QV7F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_15_1_1"/>
    <dbReference type="OMA" id="WDCPVHG"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03477">
        <property type="entry name" value="Rieske_YhfW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.10.10:FF:000014">
        <property type="entry name" value="Oxidoreductase, FAD dependent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038010">
        <property type="entry name" value="YhfW_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF281">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="7">
        <location>
            <begin position="433"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS19493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="529" mass="58974" checksum="913F7F29C800C30B" modified="2011-10-19" version="1">MTSNPSLPNPEQYMHTSGANDPVWIHKHPYNQIPTFPPLDHDLTTDICIIGAGISGIHVAHELVARGHSVVLLEARNPLSGESGRTSGHLTNDLDDGYLAIAQKHGEEGARRAAESHAWARDRIGEIAREVGVECEYRRVRAVNVSQYIRGTEEWERDMKEMKEEVELMKKLGIDARWEEDLAVKGWEGGLDQRGGMVVEGQATFHPTKYLTGVLEWLKQQKNFQCFSRTRVVGIHEKGVEMLGMGHKHAEIETEAGYKIRCEAAVEATNIPLQKLSVIAEMEYMQQYKYVRLTTCDESHDYLVVGGCDHKVGQEDTLPRFKELEEWTRERFPQAGSVDYKWSGQIMEPVDYVAFIGKNQGNDRIFIVTGDSGDGLTHGVIAGRLIADEIDGVPNDWAGLYSPKRLGSIAKSLPHMIKHDVQINLQYKRYLETDIKDIEDLAPGRGGVLNSATAKPLAVYKDPDGKVSKYSALCPHMKGVLCWNDAEKSFDCPVHGSRFSKDGICINGPAKANLPPADEAGKKDQEFAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBZ8</accession>
    <name>G0SBZ8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="8">PPIase</shortName>
            <ecNumber evidence="8">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0055370</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="8"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695869.1">
        <property type="nucleotide sequence ID" value="XM_006695806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBZ8"/>
    <dbReference type="STRING" id="759272.G0SBZ8"/>
    <dbReference type="GeneID" id="18259575"/>
    <dbReference type="KEGG" id="cthr:CTHT_0055370"/>
    <dbReference type="eggNOG" id="KOG0865">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_12_0_1"/>
    <dbReference type="OMA" id="ENFKRTH"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000032">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF385">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="9">
        <location>
            <begin position="79"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS18924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="230" mass="25326" checksum="B9F21540690A7967" modified="2011-10-19" version="1">MFRPLLPRHLPRSSSLLRNLSTPLTSACSPSLQSTFSISARAFSVSAADMSQCYFQLEWEGPTMDERGNLTSQVRLQSGRIVFNLFDDVVPKTARNFRELCTGVHGYGYKGSTFHRIIPEFMLQGGDFTRGNGTGGRSIYGEKFADENFKLKHDRPGRLSMANAGPNTNGSQFFITTVKTSWLDGRHVVFGEVADEESMKVVKLIEATGSPSGAIRYSKKPTIVDCGVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0SC04</accession>
    <name>G0SC04_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0055430</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695875.1">
        <property type="nucleotide sequence ID" value="XM_006695812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SC04"/>
    <dbReference type="STRING" id="759272.G0SC04"/>
    <dbReference type="GeneID" id="18259581"/>
    <dbReference type="KEGG" id="cthr:CTHT_0055430"/>
    <dbReference type="eggNOG" id="KOG2084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028281_6_1_1"/>
    <dbReference type="OMA" id="YAMFGHE"/>
    <dbReference type="OrthoDB" id="1028014at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF6">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="5"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="278" mass="32080" checksum="24087C57C1E9926F" modified="2011-10-19" version="1">MQQLPALVIHPTPHMDMHPEKREDFYRSAIEQLPKKTQESFMRQMGESFYEKVVKNSFRAFVDDVAHLAVYPKVSRFNHDCRPNVHYRLSGLIHTTVAVRDIPAGTELTISYIYVRKSRAERQKELSESWNFTCTCEQCSKSAEEIAASDARMRRIKALEEDIERKVIESARKRGSEDTSGLNPDMAGELVELYLTERLDAHLGPVYVRAALLYAMFGHEEKAKEYATEAAAALEREYGPHARDIPSMRDLAERPRDHWAWGLKAVDYNTMRKNDTML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0SC16</accession>
    <name>G0SC16_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Threonine/serine exporter-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0055560</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ThrE exporter (TC 2.A.79) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695887.1">
        <property type="nucleotide sequence ID" value="XM_006695824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SC16"/>
    <dbReference type="GeneID" id="18259594"/>
    <dbReference type="KEGG" id="cthr:CTHT_0055560"/>
    <dbReference type="eggNOG" id="ENOG502QPMM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007078_2_1_1"/>
    <dbReference type="OrthoDB" id="413008at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051361">
        <property type="entry name" value="ThrE/Ser_Exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082:SF4">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="514"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="537"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="565"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="604"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="653"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="807"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="909"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/serine exporter-like N-terminal" evidence="4">
        <location>
            <begin position="382"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="109"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="287"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="766"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="767"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="786"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS18942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="944" mass="102438" checksum="22ABFB69D996ADFE" modified="2011-10-19" version="1">MASPPERSEEPSVPPSPGQGTEPTSPSSSTDTPQLSQTREKKRVGFASDLQPHGAIPASSPAHSPEGSRNIVQDYFAYSRLPYTADSTPADRATQPSSSFDSEELVAALSKILDPEDPTTGSGPSKPRPVLRKSAPLKNPVEPATTPLRSELEAKNRADRLAYSIGAASVPVSARTSLDSMNEVAVDGGVLSQQSTATPTHPRLAESGDINDLRSQKRTRLEADQFVKSHLRRKSPLSRSIVPSLPETATPLEDDMDYVPPPEKYRGGILGTLLKLYTSDTDKFGSTYTDTSASSTPASTPPHSRSGTPRPEFRRPRPWRNQSSSSTLAGLVESSFMFAAPGSGKDMSEKVKKVKKSVKSKKKDEEYRVKIHIAEIIKRHTYLITLCKALMSYGAPTHRLEAYMRMSARVLEIEGQFLYLPDTMIISFDDSNTHTTEVKIVRAPQGLDFGRLRDVHEIYKDVVHDRIGVEEATVRLQEVIDRKPEFSVWLRILLYGVASALVAPFGFEGRPIDMPICFILGCLVGFLQLYLAPANELYANVFEITAAVATSFLARVFGSIRNGRLFCFSSLAQASIALILPGWLVLCASLELQNRQIISGAVRMVYSLIYTLFLGYGFTIGSILYGYMDKHAVSDIHCSSGDTWYTKRPPENFYLLFVFPFTICLCAINQAKWKQIPVQVLIALAGFSVNHFSGRFFKGNGIISSSLGTLTVGLLANLYSRLGRYCENFFLDLWEFHIEPRLSRLFLRHRCSSAAPYYTAAATSSEHTLHTGKERVPDPELGAAIPTSTAPNTRPSSATGSNRKRKIGYGLAATAMLPGIFVQVPSGLASTGSLLSGVTSADQIVRNETILGNGTIVNGTVGPVPVAVPSSSSTGSMTGMGSSMAGDPTASLAATISQSGQLNNSAFNVLFSVIQVAINLSVGLSLSALLVYPFGKRRSGLFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0SC80</accession>
    <name>G0SC80_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0056260</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695951.1">
        <property type="nucleotide sequence ID" value="XM_006695888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SC80"/>
    <dbReference type="GeneID" id="18259664"/>
    <dbReference type="KEGG" id="cthr:CTHT_0056260"/>
    <dbReference type="eggNOG" id="ENOG502SPNY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029638_0_0_1"/>
    <dbReference type="OMA" id="MLLDNHH"/>
    <dbReference type="OrthoDB" id="5387895at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="118"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="438"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="448"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="484"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="507"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="537"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="550"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="586"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS19006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="625" mass="67806" checksum="0D8AD4680327E72D" modified="2011-10-19" version="1">MSRLSLESDSDSIREHSWVPSQRSSPSEWQQDPSDWESGEDDDEEEDTDIVTSPSGFRYNISRLSPRTKKVVKSLFRESPSRDPPQISLELCGIRQEDPHGNGYFYAFQLHETVPCSVRIGAKSSGRFAIPRCECPDARYRRVRPCKHLIWLFDRIAKQTLFDHDPDSELTLTEYGYPQELGDPFDQISQLRLDVLADALRCNISDPDSDSSPPSLSRLREAADIVASLAGIPPHEVPTPQPPPSSDRSLIHRGDLASTLISLLLASHSLTEWLRSALDPLLDPAVDPFRQIQHRVDRVLFELSSYPSSSQRNPLKQAEGPRNAPWAATQIQRCVKRIETLLTRSTAPLPPVSRASAAQALVHILRSVATHSDPELYRLLIGDAKDTSFAVNALALLPEQSQFAEDLAGVMEVIGKRGAGGKWAEEMSALVARMRRYRPPEPEPGTVGSASTVSAPSMGQTPPLNISPTAQSSPAPVQLTPSASSTQPQLHPHPSQPQKKPSPPPKFTTRTSTSSSSGGNFHFLAPITPKTSLTRGRGGRGLRGRGRGSTGTSRSSKTSGPRGGKRPAPGSANDETRIWDTPSVGAGSGVVAGGRRGSAEFAGGGTVERIEAESGRTSPKRPRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCB1</accession>
    <name>G0SCB1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0056590</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695982.1">
        <property type="nucleotide sequence ID" value="XM_006695919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCB1"/>
    <dbReference type="GeneID" id="18259697"/>
    <dbReference type="KEGG" id="cthr:CTHT_0056590"/>
    <dbReference type="HOGENOM" id="CLU_2483164_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="87" mass="10345" checksum="E8BF1B344A20FBDD" modified="2011-10-19" version="1">MVATATRSKGGRGPAVQTEKEQEQEQEQEQEQEQEQEQEQEQEQEQMGKGETKKEKKKDKKKREPELPAVEELPKRRRGRPPRRYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCC4</accession>
    <name>G0SCC4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EXS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0056720</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695995.1">
        <property type="nucleotide sequence ID" value="XM_006695932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCC4"/>
    <dbReference type="STRING" id="759272.G0SCC4"/>
    <dbReference type="GeneID" id="18259710"/>
    <dbReference type="KEGG" id="cthr:CTHT_0056720"/>
    <dbReference type="eggNOG" id="KOG1162">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024081_2_1_1"/>
    <dbReference type="OMA" id="FRRWIWI"/>
    <dbReference type="OrthoDB" id="2159384at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF46">
        <property type="entry name" value="PROTEIN ERD1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51380">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="EXS" evidence="6">
        <location>
            <begin position="194"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS19050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="413" mass="46844" checksum="6129A0B076BDA326" modified="2011-10-19" version="1">MDGDPAVDPRLDSFSLTFPLPFRVAFLVILGVWGWGVNLHFLHIRRIDVPALIRYPARSSPAQLSHHHSTYRLASLLSTCTAVFLVFFWLCTRRDPQSVIDYDWIPMINLAVLFGLLLLPLRRIAVAHSGRSRLLWMLRRISVGGLAEVKDGKFADILLADALTSYAKVLADLFVCLCMFFFDGPNGSATARPDRACGGDILVPLIMAVPSAIRLRQCLIEYVRVRRAQFRDPSVGWGGQHLANATKYATAFPVIILATMLRNSAKVDSDGDGSPGLYRAWVLACLVNSLYSFYWDVAKDWDLTLFSDERAAPDHPYGLRRRLLVHKPVVYYVVIAMDLLLRLTWTVKLSATMDRIADFESSIFLLQFLEVFRRWVWIFFRVETEWIRSTSGADDASLILLGEYQGSKYEDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCL4</accession>
    <name>G0SCL4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <ecNumber evidence="3 11">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0057650</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="3 11"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696085.1">
        <property type="nucleotide sequence ID" value="XM_006696022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCL4"/>
    <dbReference type="STRING" id="759272.G0SCL4"/>
    <dbReference type="GeneID" id="18259803"/>
    <dbReference type="KEGG" id="cthr:CTHT_0057650"/>
    <dbReference type="eggNOG" id="KOG0563">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013524_2_0_1"/>
    <dbReference type="OMA" id="ERAGYYE"/>
    <dbReference type="OrthoDB" id="60984at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000015">
        <property type="entry name" value="Glucose-6-phosphate 1-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000111">
        <property type="entry name" value="Glucose-6-phosphate 1-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429:SF0">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 11" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="6 11" id="KW-0521">NADP</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase NAD-binding" evidence="12">
        <location>
            <begin position="20"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase C-terminal" evidence="13">
        <location>
            <begin position="199"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS19140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="576" mass="65298" checksum="BF70C1C475D6AE5C" modified="2011-10-19" version="1">MASDLHSSAPIELKEDTVIVVLGASGDLAKKKTYPALFGLYRNQFLPKDIRIVGYARTKMDHEEYIRRIKSYIKTPTKEVEEQLEEFCKLCTYVSGQYDRDESFMQLNEHLEELERGRKHNHRLFYMALPPSVFTIVSQHLKKCCYPKRGIARVIVEKPFGKDLASSRELQKSLEPDWKEEEIFRIDHYLGKEMVKNILILRFGNSFLGATWNRHHIDNVQITFKEPFGTEGRGGYFDEFGIIRDVMQNHLLQVLTLLAMERPISFSAEDIRDEKVRVLRAIPAIEPKNVIIGQYGRSLDGSKPGYKEDETVPKDSRCPTFCALVVYIKNERWDGVPFIMKAGKALNEQKTEIRVQFKDVTTGIFKDIPRNELVMRIQPNESVYIKMNSKLPGLTMQTVVTELDLTYRRRFSDLKIPEAYESLILDCLKGDHSNFVRDDELDASWRIFTPLLHYLDDNKEIIPMEYPYGSRGPAILDDFTASYGYKFSDAAGYQWPTTSALGPGIKLIGLTRPKIPDVHGVPDTITQPEFGGSIGVCRAAGVRCGGAAARLSRPLSVSEARTGAAADPGPGKGIVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCX7</accession>
    <name>G0SCX7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="7">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0058730</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2023-06" db="PDB data bank">
            <title>The ERAD misfolded glycoprotein checkpoint complex from Chaetomium thermophilum (EDEM:PDI heterodimer).</title>
            <authorList>
                <person name="Roversi P."/>
                <person name="Hitchman C.J."/>
                <person name="Lia A."/>
                <person name="Bayo Y."/>
            </authorList>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.60 ANGSTROMS) OF 63-1092</scope>
        <scope>DISULFIDE BONDS</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="7"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696193.1">
        <property type="nucleotide sequence ID" value="XM_006696130.1"/>
    </dbReference>
    <dbReference type="PDB" id="8PKO">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.60 A"/>
        <property type="chains" value="A=63-1092"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCX7"/>
    <dbReference type="EMDB" id="EMD-17749"/>
    <dbReference type="SMR" id="G0SCX7"/>
    <dbReference type="STRING" id="759272.G0SCX7"/>
    <dbReference type="GeneID" id="18259911"/>
    <dbReference type="KEGG" id="cthr:CTHT_0058730"/>
    <dbReference type="eggNOG" id="KOG2429">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003818_2_0_1"/>
    <dbReference type="OMA" id="CTPLTRD"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044322">
        <property type="term" value="C:endoplasmic reticulum quality control compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904380">
        <property type="term" value="P:endoplasmic reticulum mannose trimming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044674">
        <property type="entry name" value="EDEM1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679:SF5">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="11" id="KW-0002">3D-structure</keyword>
    <keyword evidence="6 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="501"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="522"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="582"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 11">
        <location>
            <position position="608"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="11">
        <location>
            <position position="913"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="99"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="963"/>
            <end position="985"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS19248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="8PKO"/>
        </source>
    </evidence>
    <sequence length="1092" mass="120269" checksum="DC04E87B14EB9A9F" modified="2011-10-19" version="1">MSCRFLAAGDSRPGARDSVIIRPSRSWWHILILAGHVLFWAWAALALFLPQWSVIPVVAAMRPDRVRALRRETVEMFYYGFDNYMKVAFPEDELRPVSCTPLTRDLKNPRNFELNDVLGNYSLTLIDSLSTLAILASAPAEDSGTGPKALRDFQDGVAALVEQYGDGRPGPSGVGRRARGFDLDSKVQVFETVIRGVGGLLSAHLFAIGALPITGYQPLRQEDDLFNPPPIPWPNGFTYDGQLLRLALDLAQRLLPAFYTKTGLPYPRVNLRHGIPFYVNSPLHEDPPAKGTTEGPPEITETCSAGAGSLVLEFTVLSRLTGDPRFEQAAKRAFWAVWYRKSQIGLIGAGVDAEQGHWIGTYSVIGAGADSFFEYALKSHILLSGHALPNQTHPSPLHKDVNWMDPNTLFEPLSDAENSAESFLEAWHHAHAAIKRHLYSEREHPHYDNVNLWTGSLVSHWVDSLGAYYSGLLVLAGEVDEAIETNLLYAAIWTRYAALPERWSLREKTVEGGLGWWPLRPEFIESTYHLYRATKDPWYLYVGEMVLRDITRRCWTPCGWAGLQNVLSGEKSDRMESFFLGETTKYMYLLFDDDHPLNKLDASFVFTTEGHPLILPKPKSARRSRNSPRSSQKALTVYQGEGFTNSCPPRPSITPLSGSVIAARDDIYHPARMVDLHLLTTSKHALDGGQMSGQHMAKSNYTLYPWTLPPELLPSNGTCAKVYQPHEVTLEFASNTQQVLGGSAFNFMLSGQNLERLSTDRIRVLSLSGLKITLQLVEEGEREWRVTKLNGIPLGRDEYVVINRAILGDVSDPRFNLVRDPVIAKLQQLHQVNLLDDTTTEEHPDNLDTLDTASAIDLPQDQSSDSEVPDPANLSALLPDLSSFVKSLFARLSNLTSPSPDPSSNLPLNVVINQTAILPTGIGAAPLPPAASNSPSGAPIPVFGPVPESLFPWKTIYAAGEACAGPLPDSAPRENQVILIRRGGCSFSDKLANIPAFTPSEESLQLVVVVSDDEHEGQSGLVRPLLDEIQHTPGGMPRRHPIAMVMVGGGETVYQQLSVASAIGIQRRYYIESSGVKVKNIIVDDGDGGVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G0SD30</accession>
    <name>G0SD30_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8021 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0050610</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695405.1">
        <property type="nucleotide sequence ID" value="XM_006695342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SD30"/>
    <dbReference type="STRING" id="759272.G0SD30"/>
    <dbReference type="GeneID" id="18259099"/>
    <dbReference type="KEGG" id="cthr:CTHT_0050610"/>
    <dbReference type="eggNOG" id="ENOG502SHGJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067389_0_0_1"/>
    <dbReference type="OMA" id="KGDWLFD"/>
    <dbReference type="OrthoDB" id="3515051at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058334">
        <property type="entry name" value="DUF8021"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26061">
        <property type="entry name" value="DUF8021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409033" description="DUF8021 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8021" evidence="2">
        <location>
            <begin position="152"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS18460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="278" mass="30423" checksum="6EB70E29E3BF30A4" modified="2011-10-19" version="1">MPEMLSILVFSIITPVVSFAGNCTREFLKTSADSLVAAQTAGNPELLQPKSNNFEYHENFAEASFTAGILSSPLKVDHNRHSLDTTQCATYTEIVSATGSKPYVIGVQMYFTDNVISKVATLITTTGDWLFNATGTLYWASREDWSTIPEEKRDSRDVIQAAAEAYLNLFSDNSTVVPWGYPCSRLEGGMYTGNGGPNDRCDVGIPSGVSLVSRRYVIDETAGAVSVFLSFSGLPDSHEFRIEGGKLRYVHTITVLSVRANGKEKMRARKAMATYPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDH9</accession>
    <name>G0SDH9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0051850</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695525.1">
        <property type="nucleotide sequence ID" value="XM_006695462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDH9"/>
    <dbReference type="STRING" id="759272.G0SDH9"/>
    <dbReference type="GeneID" id="18259223"/>
    <dbReference type="KEGG" id="cthr:CTHT_0051850"/>
    <dbReference type="eggNOG" id="ENOG502SN25">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006594_0_0_1"/>
    <dbReference type="OMA" id="DERTMDY"/>
    <dbReference type="OrthoDB" id="3870679at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <dbReference type="Proteomes" id="UP000008066"/>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDL2</accession>
    <name>G0SDL2_CHATD</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0052180</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
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            <taxon>Dikarya</taxon>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006695495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDL2"/>
    <dbReference type="GeneID" id="18259256"/>
    <dbReference type="KEGG" id="cthr:CTHT_0052180"/>
    <dbReference type="eggNOG" id="ENOG502QRGR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032158_1_1_1"/>
    <dbReference type="OMA" id="GSMPVCH"/>
    <dbReference type="OrthoDB" id="5402974at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031563">
        <property type="entry name" value="MOT1/MOT2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31970:SF9">
        <property type="entry name" value="MOLYBDATE TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16983">
        <property type="entry name" value="MFS_MOT1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="116"/>
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            <begin position="341"/>
            <end position="361"/>
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    </feature>
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        </source>
    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGS18613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="473" mass="49339" checksum="C79EE95C876EACB1" modified="2011-10-19" version="1">MPHAEPSSLFSLIAFLADPTPEGGIAELARRARYNVRTLLSNPAGEISGALGDLGTLLPIMIAMTLQGAVDLPATLVSSGVWSVVAGGVFGVPVGVQPMKAIASTSLSHPLPLEIVTASGALVSLALLLLLATNLLPLLASSIPLPLIKGIQLGAALRLALSSANLILPLPWLPSFSLTGGFLNCRVAAAILFFAAFAGQRLAPRFPTTLALFLLAAAFTSPSPGEPQDSPKLQHRIIPPPNFISALTYTTALAQLPLTLLNSILAVTSLAETLYPPSPLTLLGLPPSEETWTPSAPSTTSLALSIALINPLTARWGAMPLCHGAGGLAAQYFFGARSGSAIILLGLVKLALGLWTAFIGPQGEYTVIAWLKGFPKSVLGVMVFLAGLELAKGCLPGEERPGVKDVEGERESWVVTMVTAVGGVAYKNDGVGFVMGLGIWVLQRGERWLRQKGEGRRGESEPLLVPGGFPEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDM5</accession>
    <name>G0SDM5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CTHT_0052310</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695571.1">
        <property type="nucleotide sequence ID" value="XM_006695508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDM5"/>
    <dbReference type="SMR" id="G0SDM5"/>
    <dbReference type="STRING" id="759272.G0SDM5"/>
    <dbReference type="GeneID" id="18259269"/>
    <dbReference type="KEGG" id="cthr:CTHT_0052310"/>
    <dbReference type="eggNOG" id="ENOG502RAK7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031730_0_2_1"/>
    <dbReference type="OMA" id="SGLQWFK"/>
    <dbReference type="OrthoDB" id="2525337at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF13">
        <property type="entry name" value="ENDOGLUCANASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409491" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="16">
        <location>
            <begin position="20"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="17">
        <location>
            <begin position="18"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGS18626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="246" mass="26312" checksum="5B1250DD84A8CFDF" modified="2011-10-19" version="1">MKLSLASLLTAALSVQGHAIFQKVSINGQDHGQLTGLRAPNTNYPVEDVNSQDIICGQSGHRSSTILNVRAGDRIGTFWGHVIGGAQFPGDPDNPIARSHKGPIQVYLAKVDNAASASHTGLRWFKIWSEGFDVGSKRWGVDTMINNGGWYYFNLPQCIADGQYLMRVELLALHSAGNYRGAQFYQSCAQINVSGGGSFTPSQTVSFPGAYSQNDPGILVNIYGLTGQPDNGGKPYQAPGPAPITC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDQ1</accession>
    <name>G0SDQ1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">General transcription and DNA repair factor IIH subunit TFB5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0052580</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2020" name="Nucleic Acids Res." volume="48" first="12282" last="12296">
            <title>How to limit the speed of a motor: the intricate regulation of the XPB ATPase and translocase in TFIIH.</title>
            <authorList>
                <person name="Kappenberger J."/>
                <person name="Koelmel W."/>
                <person name="Schoenwetter E."/>
                <person name="Scheuer T."/>
                <person name="Woerner J."/>
                <person name="Kuper J."/>
                <person name="Kisker C."/>
            </authorList>
            <dbReference type="PubMed" id="33196848"/>
            <dbReference type="DOI" id="10.1093/nar/gkaa911"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.68 ANGSTROMS)</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="function">
        <text evidence="9">In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the 7-subunit TFIIH core complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the TFB5 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695597.1">
        <property type="nucleotide sequence ID" value="XM_006695534.1"/>
    </dbReference>
    <dbReference type="PDB" id="6TRS">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.68 A"/>
        <property type="chains" value="D=1-72"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDQ1"/>
    <dbReference type="SMR" id="G0SDQ1"/>
    <dbReference type="STRING" id="759272.G0SDQ1"/>
    <dbReference type="GeneID" id="18259296"/>
    <dbReference type="KEGG" id="cthr:CTHT_0052580"/>
    <dbReference type="eggNOG" id="ENOG502SBQE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166246_3_1_1"/>
    <dbReference type="OMA" id="IYNPMDE"/>
    <dbReference type="OrthoDB" id="354at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006294">
        <property type="term" value="P:nucleotide-excision repair, preincision complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1220:FF:000002">
        <property type="entry name" value="RNA polymerase II transcription factor B subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1220">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035935">
        <property type="entry name" value="TFB5-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009400">
        <property type="entry name" value="TFIIH_TTDA/Tfb5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28580">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28580:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06331">
        <property type="entry name" value="Tfb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01395">
        <property type="entry name" value="Tbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142897">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="12" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS18652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="6TRS"/>
        </source>
    </evidence>
    <sequence length="72" mass="8417" checksum="93A24A26C03D1166" modified="2011-10-19" version="1">MVRAIRGVLIECEPAIKSIIVHLDSINHDFIIEDLDDHHLVVKENMVQILKQKLEDRLRETYRPEEPLADSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDR7</accession>
    <name>G0SDR7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Riboflavin synthase</fullName>
            <ecNumber evidence="4">2.5.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0052740</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.9" evidence="4"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695613.1">
        <property type="nucleotide sequence ID" value="XM_006695550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDR7"/>
    <dbReference type="STRING" id="759272.G0SDR7"/>
    <dbReference type="GeneID" id="18259312"/>
    <dbReference type="KEGG" id="cthr:CTHT_0052740"/>
    <dbReference type="eggNOG" id="KOG3310">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034388_1_1_1"/>
    <dbReference type="OMA" id="HFVTGHV"/>
    <dbReference type="OrthoDB" id="10258924at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004746">
        <property type="term" value="F:riboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00402">
        <property type="entry name" value="Riboflavin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000004">
        <property type="entry name" value="Riboflavin synthase, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000006">
        <property type="entry name" value="Riboflavin synthase, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001783">
        <property type="entry name" value="Lumazine-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026017">
        <property type="entry name" value="Lumazine-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006767">
        <property type="entry name" value="PRK09289.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00187">
        <property type="entry name" value="ribE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098:SF0">
        <property type="entry name" value="RIBOFLAVIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098">
        <property type="entry name" value="RIBOFLAVIN SYNTHASE ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00677">
        <property type="entry name" value="Lum_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000498">
        <property type="entry name" value="Riboflavin_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51177">
        <property type="entry name" value="LUMAZINE_BIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lumazine-binding" evidence="10">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="9">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="10">
        <location>
            <begin position="105"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="9">
        <location>
            <begin position="105"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS18668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="240" mass="26075" checksum="916A73971ABD486B" modified="2011-10-19" version="1">MFTGIVEEIGVIAELNPNDSTGGTSLTVALPRESTLLSDCHLGDSIAVNGVCLTVTSFTVTPAPQFTVGIAPETLRLTNLGDLTQGSRVNLERAVRADTRMGGHFVQGHVDTTAEIIDKRPDGNAVTFRFQPKNREVLRYVVFKGFVAIDGASLTVTKVNDEEGWWEVMLIAYTQERVVTAAKEVGQTVNVEVDMTAKYVEKGLMGYLEGLEKENGEGGVSTVLERMVQRAVEKALAERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEA2</accession>
    <name>G0SEA2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0063030</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696610.1">
        <property type="nucleotide sequence ID" value="XM_006696547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEA2"/>
    <dbReference type="GeneID" id="18260341"/>
    <dbReference type="KEGG" id="cthr:CTHT_0063030"/>
    <dbReference type="eggNOG" id="ENOG502T426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111200_0_0_1"/>
    <dbReference type="OMA" id="WKGMVED"/>
    <dbReference type="OrthoDB" id="3993201at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="231" mass="24835" checksum="DD739D4238C62594" modified="2011-10-19" version="1">MSSRIAPMSRLARAFSTTPAVSRPSQLLHNTSKTLAGASRKSKLPADEETNATANYSTTSTSSPHRPSAVNNTLPRRSKPLPFMQTFHHSAPKPKPAPPITMDRMVLPNLWAEPAEDSTDFIRVPLLPDNRVPPPPQFRPVEPEPSPVPASEIVVVASDPQTVLPSALTEAEGMGIGIDGVELKFAHLLGREEEQAPELGQGMIRDMWKGLMEDIFGAEGKQGKSGPAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEL5</accession>
    <name>G0SEL5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0064170</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696723.1">
        <property type="nucleotide sequence ID" value="XM_006696660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEL5"/>
    <dbReference type="GeneID" id="18260455"/>
    <dbReference type="KEGG" id="cthr:CTHT_0064170"/>
    <dbReference type="eggNOG" id="ENOG502SCNK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052827_4_2_1"/>
    <dbReference type="OMA" id="EYPDCIT"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF6">
        <property type="entry name" value="THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="2">
        <location>
            <begin position="129"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS18392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="235" mass="25526" checksum="E90D262601187E61" modified="2011-10-19" version="1">MSETQQLPSIQPSTPSPAQFIPPPPANLTTANLPQENARAAAAQIAFFRAIPWCNALLSRPRIVIDQSVSRQLKPPTSGLDTLLSKTLNTLSTIPAYVTFYVLPETAEDLIGEVHSLLALGHDVNGWEGICHGGLVVTLIDEVMGQVFAVNRNSGRLKGGDDVMPVTGWLNTRFERPVKTGSGREGDEVKVVLVSARLVKRDGRKFFLEGEVRADEGRVVCARGEACFVLVKEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEQ0</accession>
    <name>G0SEQ0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0064540</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696758.1">
        <property type="nucleotide sequence ID" value="XM_006696695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEQ0"/>
    <dbReference type="STRING" id="759272.G0SEQ0"/>
    <dbReference type="GeneID" id="18260492"/>
    <dbReference type="KEGG" id="cthr:CTHT_0064540"/>
    <dbReference type="eggNOG" id="KOG0159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_2_1_1"/>
    <dbReference type="OMA" id="VMCQLTW"/>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF6">
        <property type="entry name" value="CYTOCHROME P450 2C30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS18427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="56001" checksum="A032FA2166A1303E" modified="2011-10-19" version="1">MRLVDLALQVLICFLISTLFWFIVEFRRRNDRKRGPGPTLLPGLGRVHDLPLQHTWFKLKEWGDRYAARGYYRVDLLDTRFFVITDEKIAYELGILYHESKRWIARLMRNPDAFQWSLEDMASKVMCALTWDDPNQSETLIRSAWALLRQMSPAGPITNVIPQLWKLPYIINPWKQAERKRHDEQIAWWLERLKDSKEKWKKGELRQCWTCDYFEMTAAAKLDRKMTLSCDYEAACVLGMLALVGIFTVAGPLNYWLVAMVNFPEWQRAVQREVDTVCQGSLPTLEDIPRLPILRACIKETMRWRPNVPTGVAHEAEVDQEWDGCVITKGTRILPLDYAFLRNPIKFPDPESFRPERWLEPGWPTYREPLTQFPTIRGMTTFGWGQRQCLGMSLTQDEMVVACGALAWAFHLECKAHPLTGEVFPVPDNKCNSLLIVKPDPFQMAFTPRSQARRLEALRIWESANRRDLKERKVRLEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2023-02-22" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>G0SET7</accession>
    <name>G0SET7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0059660</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS17953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696284.1">
        <property type="nucleotide sequence ID" value="XM_006696221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SET7"/>
    <dbReference type="GeneID" id="18260004"/>
    <dbReference type="KEGG" id="cthr:CTHT_0059660"/>
    <dbReference type="HOGENOM" id="CLU_2413071_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="92" mass="9979" checksum="CBAF4B6F5825D3F9" modified="2011-10-19" version="1">MSTRPGNSGQEPDLYDITAAARAAEAEIIDVHHGQEVGKIPTTSTKTQERSGKMNGQERQSSRRMASGEPDLEDITAAAREAEREILEGRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G0SF14</accession>
    <name>G0SF14_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Saccharopine dehydrogenase [NAD(+), L-lysine-forming]</fullName>
            <shortName evidence="14">SDH</shortName>
            <ecNumber evidence="5 14">1.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">Lysine--2-oxoglutarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CTHT_0060440</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NAD(+)-dependent cleavage of saccharopine to L-lysine and 2-oxoglutarate, the final step in the alpha-aminoadipate (AAA) pathway for lysin biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>L-saccharopine + NAD(+) + H2O = L-lysine + 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12440"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57951"/>
            <dbReference type="EC" id="1.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.7" evidence="5 14"/>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696361.1">
        <property type="nucleotide sequence ID" value="XM_006696298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SF14"/>
    <dbReference type="STRING" id="759272.G0SF14"/>
    <dbReference type="GeneID" id="18260082"/>
    <dbReference type="KEGG" id="cthr:CTHT_0060440"/>
    <dbReference type="eggNOG" id="KOG0172">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063085_0_0_1"/>
    <dbReference type="OMA" id="YFFFSHT"/>
    <dbReference type="OrthoDB" id="265306at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00034"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004754">
        <property type="term" value="F:saccharopine dehydrogenase (NAD+, L-lysine-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd12188">
        <property type="entry name" value="SDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000217">
        <property type="entry name" value="Saccharopine dehydrogenase [NAD(+), L-lysine-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000627">
        <property type="entry name" value="Saccharopine dehydrogenase [NAD(+), L-lysine-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027281">
        <property type="entry name" value="Lys1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF23">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE [NAD(+), L-LYSINE-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018250">
        <property type="entry name" value="Saccharopine_DH_Lys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 14" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="9 14 16" id="KW-0520">NAD</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="19">
        <location>
            <begin position="7"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="18">
        <location>
            <begin position="173"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="201"/>
            <end position="202"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="336"/>
            <end position="339"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="203"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR018250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGS18030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="392" mass="43379" checksum="C84A4BE0A989C936" modified="2011-10-19" version="1">MAPTVLHLRSETKPLEHRSALTPHTAAELIKAGYVVNVERSPERIFDDAEFEAVGCTLVPEGSWPDAPEDHIIIGLKELEEKDFPLKHVHVQFAHCYKQQAGWEKVLARFPRGGGTLLDLEFLVDERGRRVAAFGFHAGFAGAALALEAWAWQQSHPEEPFPGVESYPNEEALVADVKKALEEGTAKAGRQPKVIVIGALGRCGSGAVAALRKAGVQEENILKWDMAETAKGGPFSAFKPLWVLVERDYADPGTEEITDCDIFVNCIYLTSKIPNFVNMESLQVPDRKLSVVCDVSADTTNPFNPVPIYSISTTFRNPTVRVQGLKQGPPVDVISIDHLPSLLPREASEQFSRDLLPSLLTLNNWRNEPVWARAYKLFQEKVATLPEDALKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>G0SF25</accession>
    <name>G0SF25_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Urease</fullName>
            <ecNumber evidence="2 9">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 9">Urea amidohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CTHT_0060560</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>urea + 2 H2O + H(+) = hydrogencarbonate + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Ni cation</name>
            <dbReference type="ChEBI" id="CHEBI:25516"/>
        </cofactor>
        <text evidence="11">Binds 2 nickel ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10">Carbamylation allows a single lysine to coordinate two nickel ions.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="2 9"/>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696372.1">
        <property type="nucleotide sequence ID" value="XM_006696309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SF25"/>
    <dbReference type="SMR" id="G0SF25"/>
    <dbReference type="STRING" id="759272.G0SF25"/>
    <dbReference type="MEROPS" id="M38.982"/>
    <dbReference type="GeneID" id="18260094"/>
    <dbReference type="KEGG" id="cthr:CTHT_0060560"/>
    <dbReference type="eggNOG" id="ENOG502QPKB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000980_0_0_1"/>
    <dbReference type="OMA" id="DTMDGVH"/>
    <dbReference type="OrthoDB" id="1708534at2759"/>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035550">
        <property type="term" value="C:urease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00375">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00407">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00390">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.280.10:FF:000001">
        <property type="entry name" value="Urease subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.150.10">
        <property type="entry name" value="Urease, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.280.10">
        <property type="entry name" value="Urease, gamma-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01953">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008221">
        <property type="entry name" value="Urease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011612">
        <property type="entry name" value="Urease_alpha_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050112">
        <property type="entry name" value="Urease_alpha_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017950">
        <property type="entry name" value="Urease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005848">
        <property type="entry name" value="Urease_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017951">
        <property type="entry name" value="Urease_asu_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002019">
        <property type="entry name" value="Urease_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036461">
        <property type="entry name" value="Urease_betasu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002026">
        <property type="entry name" value="Urease_gamma/gamma-beta_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036463">
        <property type="entry name" value="Urease_gamma_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029754">
        <property type="entry name" value="Urease_Ni-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009671">
        <property type="entry name" value="PRK13192.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009686">
        <property type="entry name" value="PRK13207.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01792">
        <property type="entry name" value="urease_alph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00192">
        <property type="entry name" value="urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00193">
        <property type="entry name" value="urease_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43440">
        <property type="entry name" value="UREASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43440:SF1">
        <property type="entry name" value="UREASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00449">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00699">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00547">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001222">
        <property type="entry name" value="Urease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01752">
        <property type="entry name" value="UREASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51278">
        <property type="entry name" value="Urease, beta-subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54111">
        <property type="entry name" value="Urease, gamma-subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01120">
        <property type="entry name" value="UREASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00145">
        <property type="entry name" value="UREASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51368">
        <property type="entry name" value="UREASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0533">Nickel</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urease" evidence="15">
        <location>
            <begin position="403"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="14">
        <location>
            <begin position="722"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12 13">
        <location>
            <position position="594"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="11">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="11">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="520"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="546"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="634"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="10">
        <location>
            <position position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001222-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001222-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGS18041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="840" mass="90019" checksum="12E6793191D586E3" modified="2011-10-19" version="1">MVDGVKLDKLVIAQLGLLAQRRLARGVKLNHAEAAALISSVLHELIRDGAHSVSDLMSLGATLLGRRHVLPSVPHTLHMVQVEGTFPSGTFLVTVQNPIATDDGDLARALYGSFLPVPSKEEQERLFPLPKEEKAPGAVVVVKTASGEPDVVKLNEGRRRVKLKVTNKGDRAVQVGSHYHFIEVNPLLSFDREKAYGFRLDVPSGSSLRFEPGESRTVTLVEIGGNKVIKGGNGIVNGKVDFTRTGEIVEKLVKMGFAHVPEPGADAALIQGAALDRETYAHMFGPTTGDLVRLGNTELWVRVEKDFTVYGDECKFGGGKVLRDGMGQATGRSDADTLDLVITNALVIDYTGIYKADIGVKNGVISGIGKAGNPDVMDGVTPGMVVGSCTDVIAGEGKIVTAGAIDTHIHFICPQQAYESIASGVTTLLGGGTGPSTGTNATTCSPGAFYIRSMLQSTDSLPLNIGITGKGNDSDPLALREQVLAGACGLKLHEDWGSTPAAIDSCLSVCDELDVQCLIHTDTLNESGFVESSVAAFKGRTIHTYHTEGAGGGHAPDIIRVVEHPNVLPSSTNPTRPYTKNTLDEHLDMMMVCHHLSKDIPEDVAFAESRIRAETIAAEDVLHDLGAISMMSSDSQAMGRCGEVVLRTWHTAHKNKLQRGPLKEDEGTGADNFRVKRYVSKYTINPALAQGMGHLIGSVEVGKLADLVLWEPAWFGTKPEMVLKGGFIAWAQMGDPNGSVPTIEPVIARPMFASYLPGHASVAFVSRASLENGTVTEYGLKKRVEPVKGCRTVSKRDMKYNDAMPRMKVDPERYTVEADGVVCKAEPSSELPMAQFAYVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0SF69</accession>
    <name>G0SF69_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vezatin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CTHT_0061000</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the vezatin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696416.1">
        <property type="nucleotide sequence ID" value="XM_006696353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SF69"/>
    <dbReference type="STRING" id="759272.G0SF69"/>
    <dbReference type="GeneID" id="18260138"/>
    <dbReference type="KEGG" id="cthr:CTHT_0061000"/>
    <dbReference type="eggNOG" id="ENOG502QSNT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005766_2_0_1"/>
    <dbReference type="OMA" id="DANTNML"/>
    <dbReference type="OrthoDB" id="21151at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017022">
        <property type="term" value="F:myosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026859">
        <property type="entry name" value="Myosin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026858">
        <property type="entry name" value="Vezatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15989">
        <property type="entry name" value="VEZATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15989:SF5">
        <property type="entry name" value="VEZATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12632">
        <property type="entry name" value="Vezatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin-binding" evidence="16">
        <location>
            <begin position="61"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="324"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF12632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGS18085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="525" mass="58194" checksum="A35F8EFB9858F703" modified="2011-10-19" version="1">MADEGEEQPSLPTPSVSDDPGHDESPPSSPSFAPVGRPMVKKRFRPSSTGLFATAAAAVVVAWVVKYLFSGGLAHLTKKRVAISAVILIAVASVSHAYLRQQWLRYLRNQALNEVTIFVSRSQEFDSASSAAISLIQEVELVSRGYRISAPLPPISRIEDRSQSRRCSRLRKALKGQMSEMIENYMQVTTAVKGFAEQMDLEKYHDIYDISDFDISDAMQGFTEKEFEDMESLRSLKIAAARFHTIRKILLCSLLAFEASGDNNDYLRWSTAVEGLKTLNELTLQSFERLRQLLADEETFPTIPETKLPLSPAREKRRSQFMKLNSLSTGIRGLQAKLALLREEAEKTLNEADDVNDVSELGQALMAQYESIGQDLKMLTQAWEEGKAALASGIDKHEKRISSISSLLSPASSLSGLTAIEETPGGGAAEAFKALTGESPRSSCFGSTKGDSDEAEVYEAVSLPSRPRSLLTREERIAKMKEEREQRELAHERAEANRGMLRELEMVINLRPKRATMPASSRISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G0SF92</accession>
    <name>G0SF92_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative GTP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0061230</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696439.1">
        <property type="nucleotide sequence ID" value="XM_006696376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SF92"/>
    <dbReference type="STRING" id="759272.G0SF92"/>
    <dbReference type="GeneID" id="18260161"/>
    <dbReference type="KEGG" id="cthr:CTHT_0061230"/>
    <dbReference type="eggNOG" id="KOG2655">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017718_8_0_1"/>
    <dbReference type="OMA" id="EASHAEI"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000238">
        <property type="entry name" value="Cell division control 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="28"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="318"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS18108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="385" mass="44569" checksum="DEFED8ED42AF573E" modified="2011-10-19" version="1">MAPATAESASPIGIANLPNQRHKIVAKKGASFTIMVAGESGLGKTTFINTLFSTTIKNYADHKKRHQKQIDKTVEIEITKAELEEKFFKVRLTVIDTPGFGDYVNNRDSWQPIVEFLDDQHESYMLQEQQPHRQNKIDLRVHACLYFIRPTGHTLKPLDIEVMKRLCTRVNLIPVIAKADTLSPTELAKFKQRIRAVIEAQNIKIYQPPIEEDDEAAAQHARSLIAAMPFAVIGSEKDVKTNDGRIVKGRQYSWGVAEVENEDHCDFKKLRSILIRTHMLDLIHTTEELHYEAYRAQQMETRKFGEARPRKLDNPKFKEEEEALRKRFTEQVKIEEQRFRQWEQKLIAERDRLNKDLEQTHAEIKRLEAELEALQGTAVRSHGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFE4</accession>
    <name>G0SFE4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative peptide chain release factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0061750</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696491.1">
        <property type="nucleotide sequence ID" value="XM_006696428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFE4"/>
    <dbReference type="STRING" id="759272.G0SFE4"/>
    <dbReference type="GeneID" id="18260213"/>
    <dbReference type="KEGG" id="cthr:CTHT_0061750"/>
    <dbReference type="eggNOG" id="KOG2726">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036856_0_8_1"/>
    <dbReference type="OMA" id="DHRVGFK"/>
    <dbReference type="OrthoDB" id="2019491at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000070">
        <property type="entry name" value="Related to MRF1-peptide chain release factor, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050057">
        <property type="entry name" value="Prokaryotic/Mito_RF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804:SF7">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="5">
        <location>
            <begin position="271"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="32"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS18160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="423" mass="47209" checksum="B63E3B1CF015CC97" modified="2011-10-19" version="1">MGVSELRAVAEARQHVLDGSSYTISQLPPALLERARRLADEHTKLTKELEQDFDPKKAKRAGEISRIAEALKQFEKAKAALGELQGLLQSDDRELRELAEDDLEATNAQLAESTHNLSAALTPKHPFADMPCLIEFVPGPGGTEGRFFADTLFKMYKAYCTNKGYRHRVVKYEASDSDGQTSSEGEIALQEAVLEVQEPGAYAIFRGEAGMHRVQRVPDTEKSGRTHTSAVAVWVLPSFPENTTSEQEADWDNPESDFYVNPAEVKVEVMRARGAGGQHVNKTESAVRLTHIPTGTTVSMQDSRSQQRNRDVAWRLLRSRLAQKRREAREEQARQLRDSVLARSQITRGDKIRTYNYQQDRCTDHRSALDAHNLPDVLRGGETLDKIIQSVHVWLVNQDIQALIAEEEAAASKAAKANKKSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFI2</accession>
    <name>G0SFI2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative nicotinamide mononucleotide transmembrane transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0070920</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697365.1">
        <property type="nucleotide sequence ID" value="XM_006697302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFI2"/>
    <dbReference type="GeneID" id="18261130"/>
    <dbReference type="KEGG" id="cthr:CTHT_0070920"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="OMA" id="CFFIVPG"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF46">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS17747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="402" mass="44639" checksum="B9A5A41F7D38A61A" modified="2011-10-19" version="1">MSIRSEREKHSSDEESPSPSPPSLPILPPNTSDRLLTLRIDTHILPFVITLYLLAFLDRVNIANARAFGLESDLHMTGRYDYNTALTIFFIPYILFEVPSNILLKKLSPRVWLSACCIGFGVVTVCQGFCRNFGGLLAARFFLGKWLSPSELSYLQAKLALDQGPSAAEKRITPRDVLRVLTDYKVWLGGLMYLGLIVPAYSYAFFAPTIIQAYNSSSAIETQLRSVPPWACAFGLAMIVAIASDKARHRFAFTVTPILLSVAGFGVLFSVFDKLDVQYAALFLICMGTYAAMPVIVCWFNMNLGGHHRRAVGSAWQVAFGNIGGIISTYSFLKEDAPRFTKGYAICVGFISLSVVSCVAYELAVAWENRKKEKILREGELNLTEEEKTALGDLSPEFKYML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFK8</accession>
    <name>G0SFK8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein S19-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0071200</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2019" name="Mol. Cell" volume="75" first="1256" last="1269.e7">
            <title>Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration.</title>
            <authorList>
                <person name="Cheng J."/>
                <person name="Bassler J."/>
                <person name="Fischer P."/>
                <person name="Lau B."/>
                <person name="Kellner N."/>
                <person name="Kunze R."/>
                <person name="Griesel S."/>
                <person name="Kallas M."/>
                <person name="Berninghausen O."/>
                <person name="Strauss D."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="31378463"/>
            <dbReference type="DOI" id="10.1016/j.molcel.2019.06.032"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (7.10 ANGSTROMS)</scope>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="476" last="476">
            <title>High-resolution structures of a thermophilic eukaryotic 80S ribosome reveal atomistic details of translocation.</title>
            <authorList>
                <person name="Kisonaite M."/>
                <person name="Wild K."/>
                <person name="Lapouge K."/>
                <person name="Ruppert T."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="35079002"/>
            <dbReference type="DOI" id="10.1038/s41467-022-27967-9"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.90 ANGSTROMS)</scope>
    </reference>
    <reference evidence="10 11" key="4">
        <citation type="journal article" date="2023" name="Nat. Struct. Mol. Biol." volume="30" first="670" last="677">
            <title>Structural inventory of cotranslational protein folding by the eukaryotic RAC complex.</title>
            <authorList>
                <person name="Kisonaite M."/>
                <person name="Wild K."/>
                <person name="Lapouge K."/>
                <person name="Gese G.V."/>
                <person name="Kellner N."/>
                <person name="Hurt E."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="37081320"/>
            <dbReference type="DOI" id="10.1038/s41594-023-00973-1"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.20 ANGSTROMS)</scope>
    </reference>
    <reference evidence="12" key="5">
        <citation type="journal article" date="2024" name="Nat. Commun." volume="15" first="716" last="716">
            <title>Methionine aminopeptidase 2 and its autoproteolysis product have different binding sites on the ribosome.</title>
            <authorList>
                <person name="Klein M.A."/>
                <person name="Wild K."/>
                <person name="Kisonaite M."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="38267453"/>
            <dbReference type="DOI" id="10.1038/s41467-024-44862-7"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.10 ANGSTROMS)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697391.1">
        <property type="nucleotide sequence ID" value="XM_006697328.1"/>
    </dbReference>
    <dbReference type="PDB" id="6RXX">
        <property type="method" value="EM"/>
        <property type="resolution" value="7.10 A"/>
        <property type="chains" value="Cr=1-153"/>
    </dbReference>
    <dbReference type="PDB" id="7OLC">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="ST=1-153"/>
    </dbReference>
    <dbReference type="PDB" id="7OLD">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="ST=1-153"/>
    </dbReference>
    <dbReference type="PDB" id="7Z3N">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="ST=1-153"/>
    </dbReference>
    <dbReference type="PDB" id="7Z3O">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.30 A"/>
        <property type="chains" value="ST=1-153"/>
    </dbReference>
    <dbReference type="PDB" id="8OO0">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="ST=1-153"/>
    </dbReference>
    <dbReference type="PDBsum" id="6RXX"/>
    <dbReference type="AlphaFoldDB" id="G0SFK8"/>
    <dbReference type="EMDB" id="EMD-10054"/>
    <dbReference type="EMDB" id="EMD-12976"/>
    <dbReference type="EMDB" id="EMD-12977"/>
    <dbReference type="EMDB" id="EMD-14479"/>
    <dbReference type="EMDB" id="EMD-14480"/>
    <dbReference type="EMDB" id="EMD-17004"/>
    <dbReference type="STRING" id="759272.G0SFK8"/>
    <dbReference type="GeneID" id="18261158"/>
    <dbReference type="KEGG" id="cthr:CTHT_0071200"/>
    <dbReference type="eggNOG" id="KOG3411">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108559_0_0_1"/>
    <dbReference type="OMA" id="WAPFVKT"/>
    <dbReference type="OrthoDB" id="428974at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000118">
        <property type="entry name" value="40S ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001266">
        <property type="entry name" value="Ribosomal_eS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01090">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01413">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7 8 9" id="KW-0002">3D-structure</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="117"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS17773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="6RXX"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="7OLC"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="7OLD"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="7Z3N"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="7Z3O"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="8OO0"/>
        </source>
    </evidence>
    <sequence length="153" mass="17120" checksum="BAE5D1CF2F52AA82" modified="2011-10-19" version="1">MPGGVTVRDVDAHKFVAAYAAFLKRQGKLPVPGWVDTVKTGNAKELPPQDIDWWYIRAASVARHVYLRKTVGVGRLRKVHGSAKNRGTRPSHHVDASGSVDRKIMQALEKIQVLEKDEERGGRRITQQGQRDLDRIAQTVAEADQESEAEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFN4</accession>
    <name>G0SFN4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Vacuolar import and degradation protein 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0071480</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697417.1">
        <property type="nucleotide sequence ID" value="XM_006697354.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0SFN4"/>
    <dbReference type="GeneID" id="18261186"/>
    <dbReference type="KEGG" id="cthr:CTHT_0071480"/>
    <dbReference type="eggNOG" id="ENOG502RGMX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001331_0_0_1"/>
    <dbReference type="OMA" id="KQQHASH"/>
    <dbReference type="OrthoDB" id="5364245at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46459:SF1">
        <property type="entry name" value="E1A-BINDING PROTEIN P400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46459">
        <property type="entry name" value="E1A-BINDING PROTEIN P400-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSA" evidence="12">
        <location>
            <begin position="579"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="11">
        <location>
            <begin position="844"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="223"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="477"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="646"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="939"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1226"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1449"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1187"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="271"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="285"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="319"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="939"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1457"/>
            <end position="1470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS17799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1470" mass="158935" checksum="3817954EB8658B79" modified="2011-10-19" version="1">MSELGLTDRLKLLQLKRAESSSIVQTRKRKLRELYAVATDENALPNHDFSDPDAPPTRPDEAKFLNDCDILKGRRLNDLNIPALRKRLFTLPPSSASDTIPEGIPERPLDDSSLKDEVDLLVPSQPAPKDLAAEHGTAPGSVTNTQGNVGKLQASNGSIQALNFGRTNDHVEKATLDHGSLSKQQEDSQPAGRDASTSFRDIQADTLSSPGSTAQSLTPAVHDVSANTSPDHECPHEPEKTDEAPTADQPLANGLVNGEKENHVTRVVPSTAPSQSDTGTLSPTSSAEAQLLQESAAASVLAPQDGTQKAFHPKPPSTGPTAADTSTHSADIQVGSGADKPIASSGPDVESQPKEVGDASQFMDIDQPETAGVNGPDSKSADGAINQSVAREVPTEATSKQEQPSLPSLLPPAKPIASDSSAKPLGNPDAGKQSPTASEDGHQVTGDVGKEITASQTASASQLKLLANKAQAKRRKSIPTVIFGKPQNRRKSTENKDSAVANRQRPGHIPTDDYFTPLFIEGFTRQSTWMKPLEKLLNQAHKTISTSDQYISILDHQACKILRRVYHLQQHDKWSLRQPVRCPEPVRQASHWDVLLQEMKWMRTDFREERKWKRAVARNLAYACAEWVHSSPEERLALQVNAAIPPRSSHRDSASQSDSVDEPVPDLVHSDSPMDVDDEHLETLVETVAPTALFALSEDECVFALQPSKAADLLLENLPLHSSPLQIPKFDITGSDYDPDAKWKRPAVPLSKYVEGEMVLANKGPPRKRRRYDYLAEEDDDEEEVTFGPKPDDGAMLQPEITSVALFSPEMKPIRDRLHAAHQFRPPTEHPMPPQSFYECRVASQWTLAEDEQLKTLVRECSYNWSLISTLISSPSRFVSGAERRTPWECFERWISLGSLEGLPNDMARTPYFKMYQARIEAAQRNIVQQNQAAQQQQQQQQQQQQGQQPQQQGQQQQAGSSGSAAPLIKRRLTTSIRVERRRNQKHLALIDAMRKLAKKRETAAQKAQHAANLAAMRKANEVPKQQIINKTPRDYSLMRWERDQALAERMAAYAARHAEAARRLGHGVPIPGTPGAIPVPQGAAQLAAANSLNTAARLNVPAQLAMAAGQNRTAARVPLQTPPGAVPAAVMQARLAAGGLVPPIQMAGLPQAQLQAMQAAAAAAQHRVPMVSPQPDINLMLQARSIQNQQRAAIQLQQQQQAAQQAAQQQAQAQQASAQQTQQGQQQPAVTQAPQQPPQQTQQVQQLAQAAGLQAAAAPLRSVMAGINQGAFLTNAQAMMAQFNAASAPGLVGSPGAGLSMPHLAGRAPGGFLSQQIQQRLADLENHYRTKNPQLPPETIRQLATEHLGRLIVQSQQQAAMNVAAGAVAQQPMNSPHQYASLLRAQQAQAQAQAQAQAQQAAAQQAAAQQVAAQQVAAAQQVAAAQQVAAAQQVATAQQVVAAQQAAAAQQQAAQHQRQPSGSATPATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0SG17</accession>
    <name>G0SG17_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Asl1-like glycosyl hydrolase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0064700</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696774.1">
        <property type="nucleotide sequence ID" value="XM_006696711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SG17"/>
    <dbReference type="GeneID" id="18260508"/>
    <dbReference type="KEGG" id="cthr:CTHT_0064700"/>
    <dbReference type="eggNOG" id="ENOG502S2W1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040908_3_2_1"/>
    <dbReference type="OMA" id="WYDNFAG"/>
    <dbReference type="OrthoDB" id="43654at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000207">
        <property type="entry name" value="Glycoside hydrolase family 128 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF3">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409153" description="Asl1-like glycosyl hydrolase catalytic domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="2">
        <location>
            <begin position="30"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="320" mass="35059" checksum="1EFDCD7B40671517" modified="2011-10-19" version="1">MTSLKAIVALAALGWSLSAAAGPLASPKRGLAFTPNDTTRVDDTIWITQPSCLTWYYNYKAEPEPTFSESFSQSEFEFVPMMWGAPEDASDTTFLETIKGLVKKGINITNVLSFNEPDGPWEWGGSDIEPAHAAKVWVSNLMPLQEMGIRVGLPATTGAPSGLVWLKSFLEECRKLVSTEKESRNCTYDFVTVHWYGNFEGLASHLGEYVATFPNKTVWVTEYNLAHASLAETQAFYNISAEYMDRLEEVERYSLFGAFRSDVSNVGPNAAMLTADGQLTDIGNWYLGRPAAGVNPESLGTRLSVAWVLGLLGVVVSLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0SG66</accession>
    <name>G0SG66_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0065220</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696823.1">
        <property type="nucleotide sequence ID" value="XM_006696760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SG66"/>
    <dbReference type="STRING" id="759272.G0SG66"/>
    <dbReference type="GeneID" id="18260560"/>
    <dbReference type="KEGG" id="cthr:CTHT_0065220"/>
    <dbReference type="eggNOG" id="ENOG502QW32">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014722_1_1_1"/>
    <dbReference type="OMA" id="GLMYETI"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF7">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409537" description="DUF1996 domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="3">
        <location>
            <begin position="34"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="686"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS17205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="705" mass="75872" checksum="96340D825B3D635F" modified="2011-10-19" version="1">MKFLKPLALLTSAGSVSAFWRMECRGRVGVGRIDPLISPGAASLHSHAIHGSSGFNEKATYEDLVNGECTSCAVVQDKSAYWAPNLYFRHANGTYQEVTQVGGMLAYYFLFPDAKNPEAGVTAFPNNFRMIAGDATRRNYSVGGMGPYEADPEKSLWKALGQTNQHDLAQRAIGFNCLNYAKAPEGTLYRHYLPPKAYLDEHCADGVRFELMFPSCWNGKDITSANFKDHVAYPDLVMTGTCPDGFDVKLPGLMYETIWATNEFVGVPGEFVISHGDVQGFGYHGDFISGWDENFLQAAVNQCTNLSGKLSDCPIFTLQSEDEQRACKMKIPEIVKNEKVTGLIGESLPGNIVIQYGPEPATAARPTNTEPNYVPVPTASYSAGVTASAESDILPGGVFKERPTSTVEATFSVEPTTTSANIGALAEPSPEPTPAPIPSDPPIPEGYSLVRTDYITNGNTVSKIVVIETVEYVMLATETVTVTATATPGSEKVLRCSAAVHVGGIVKRLQDWRGLLLPLWGERKMGEKSGKHQGKVSAQIGLTSAEKKGVSQVRVVEQEQQVARDQKQDTEQITSTLTKHASNSGRPEGAALLPAPVSPRDGTASAAAPDIELHEGQKQTPAFDHSSKPTPAVTVQYVDGEDTETGDENLLAVNSAISSLRYMNSAVSRNSSLLFIPGRNATPTLSGVADTIGKDTAEEDKRQHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGA8</accession>
    <name>G0SGA8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0065660</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696865.1">
        <property type="nucleotide sequence ID" value="XM_006696802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGA8"/>
    <dbReference type="GeneID" id="18260604"/>
    <dbReference type="KEGG" id="cthr:CTHT_0065660"/>
    <dbReference type="eggNOG" id="ENOG502SMUJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020690_0_0_1"/>
    <dbReference type="OMA" id="IWFPMRY"/>
    <dbReference type="OrthoDB" id="5368516at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="709" mass="77097" checksum="F74B75A7FE1B58FC" modified="2011-10-19" version="1">MFFNELRFAAAKSIRTSTIILASFNMVAAFATAVGILCDSYFRSRRNRRLQLRPNGFWDFVPEGELYPLILSIAIVIQSATFAGAQSTGLKSLFGLGCTTMAQLMLPAVFLVPYIQLVFAVEIAIRGLKKSPFAPRGKYDVSICLAIVGLLTLAKFLVAGFDRSPNFCLTSLFWFVAHYSVMCFGLFVSIAAIILGCIVVVFTRLYRSIKVEVTARVSASKMIYYMAHSVISLGFMIPFFFVQGFRDRLGQPSNALTLAMVASVVANVSGLMTGGLYLFLKSSTLSTIGPMDKAGEYEDRQLRYKIQRVETSDDDRSEDFDFQITHPVGRPGRFTSESTLINTEKEEEAALDSQSAKWRRTPESTRSSKLAAMAAAILPKAPQPARIPAAASIAGHMRKRSYSLFPKTASRVPGTTLPATTYVPTEDDLKPPPSMANLVNTRHKRDSSLVSSATVQIGLRLSSVDDIPPAAATTPDNVVHTLDCPNLMKEKGMTRPQAVVFSPTTATSNGGTNVQDEPVKDARMKTLPPVPKLDTAVGVAVKVDQPLPKSQDEVLTLSSSVYTPVSGEKPAKQQEVFTLSPTVYTPPSPSKKTKQKQEEPVTLSPTVYTPSSNTPKQQQSKQEPVTLSPTVYTPPFVEPKPGTQPPPPPQLDEPITLTSAAYKQTTPTTARVKLPSPKGVGFSMPEGDIQYKHSSTAASTEKPTPEEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGC1</accession>
    <name>G0SGC1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]</fullName>
            <ecNumber evidence="8">1.5.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Saccharopine reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0065790</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-saccharopine + NADP(+) + H2O = (S)-2-amino-6-oxohexanoate + L-glutamate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57951"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.10" evidence="8"/>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696878.1">
        <property type="nucleotide sequence ID" value="XM_006696815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGC1"/>
    <dbReference type="STRING" id="759272.G0SGC1"/>
    <dbReference type="GeneID" id="18260617"/>
    <dbReference type="KEGG" id="cthr:CTHT_0065790"/>
    <dbReference type="eggNOG" id="KOG0172">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016207_3_1_1"/>
    <dbReference type="OMA" id="WNYKFTW"/>
    <dbReference type="OrthoDB" id="10059875at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004755">
        <property type="term" value="F:saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000008">
        <property type="entry name" value="Alpha-aminoadipic semialdehyde synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000072">
        <property type="entry name" value="Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1870.10:FF:000002">
        <property type="entry name" value="Saccharopine dehydrogenase Lys9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1870.10">
        <property type="entry name" value="Domain 3, Saccharopine reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF22">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="11">
        <location>
            <begin position="9"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase-like C-terminal" evidence="12">
        <location>
            <begin position="127"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00083134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS17260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="450" mass="49251" checksum="6B67219D3106FA4C" modified="2011-10-19" version="1">MSDLSQYKVLMLGAGFVTRPTLDVLSEAGIPVTVACRTLATAQKLAEGVPTATPISLDVTNDQALDAEVAKHDLVISLIPYTFHATVIKSAIRNKKHVVTTSYVSPAMQELDAAAKEAGITVMNEIGLDPGIDHLYAIKTIEEVHRAGGKIISFLSYCGGLPAPEDSDNPLGYKFSWSSRGVLLALRNAGKWWQDGRVVEVAPKDLMKTAKPYFIYPGYAFVAYPNRDSTAYKERYNIPEAQTVIRGTLRYQGFPQFIKVLVDIGFLEDTPLDILSKPVAWREATQAVIGAPSSSAADLEATILSKATFESEEDKKRILSGLRWIGLFSDEPITPKGNPLDTLCATLERKMQYGPGERDLVMLQHKFEIEHADGTRETRTSTLVEYGDPNGYSAMAKTVGVPCAVAVKQVLSGQIKEKGILAPMTWEICEPLMKELAEKHGITMVEKTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGH3</accession>
    <name>G0SGH3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0066330</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2020" name="Nat. Struct. Mol. Biol." volume="27" first="233" last="239">
            <title>The structure of the cohesin ATPase elucidates the mechanism of SMC-kleisin ring opening.</title>
            <authorList>
                <person name="Muir K.W."/>
                <person name="Li Y."/>
                <person name="Weis F."/>
                <person name="Panne D."/>
            </authorList>
            <dbReference type="PubMed" id="32066964"/>
            <dbReference type="DOI" id="10.1038/s41594-020-0379-7"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 1-242 AND 265-1264 IN COMPLEX WITH MG(2+)</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696930.1">
        <property type="nucleotide sequence ID" value="XM_006696867.1"/>
    </dbReference>
    <dbReference type="PDB" id="6QPQ">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.10 A"/>
        <property type="chains" value="A/C=1-242, A/C=265-1264"/>
    </dbReference>
    <dbReference type="PDB" id="6QPW">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.30 A"/>
        <property type="chains" value="A=1-242, E=1059-1264"/>
    </dbReference>
    <dbReference type="PDBsum" id="6QPQ"/>
    <dbReference type="PDBsum" id="6QPW"/>
    <dbReference type="AlphaFoldDB" id="G0SGH3"/>
    <dbReference type="EMDB" id="EMD-4616"/>
    <dbReference type="SMR" id="G0SGH3"/>
    <dbReference type="STRING" id="759272.G0SGH3"/>
    <dbReference type="GeneID" id="18260671"/>
    <dbReference type="KEGG" id="cthr:CTHT_0066330"/>
    <dbReference type="eggNOG" id="KOG0018">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001042_0_1_1"/>
    <dbReference type="OMA" id="KHMDFQR"/>
    <dbReference type="OrthoDB" id="5575062at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03275">
        <property type="entry name" value="ABC_SMC1_euk"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028468">
        <property type="entry name" value="Smc1_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF12">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="16 17" id="KW-0002">3D-structure</keyword>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="13">
        <location>
            <begin position="550"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="77"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="201"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="359"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="431"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="505"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="701"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1040"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS17312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="6QPQ"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PDB" id="6QPW"/>
        </source>
    </evidence>
    <sequence length="1264" mass="145770" checksum="D22BDCEC8E96F83F" modified="2011-10-19" version="1">MGKLIRLELFNFKSYKGHHTLLFGDSYFTSIIGPNGSGKSNSMDAISFVLGIKSSHLRSSNLRDLIYRGRVMKTSKIQDDGTTAPATNGDVNGYENGDAGDDEDTSQRTSRNDPKTAWVMAVYEDDAGELHRWKRTITANGTSEYRINDRVVNAQQYNEALEKENILIKARNFLVFQGDVEAIASQSPQDLTRLIEQISGSLEYKEEYERLEEEVRQATEEQAYKLQRRRAANSEIKQYMEQKQEAEKFQKASEERDKAIIAHILWKLYHFQRVMVESSARIQEHQENLKEFRRNVEAYEKKLDAARKEQLAVGREVAKIERNIHEKQRSIDDRNNMLVPVDEKITQSSQEAVMLRKRLADVKKDRDEKSEVIQKLKKDLATVEKAQQQFEKQWAETVKKQGKELSDADRREYTALQAEVMRKTSDNRAKLANLERQLKGDEVTVNSLKGKIDSFEATIEKLQSEVQTIKERRDACQDSVLQITSEIDSKKKEFNSMQSERIRINNTHTELEEKLRDVLRRLEEAELGRRQNEKELKMRNMVSDLKRIYPGVRGRVGELCRPKQKKYDEAVITALGREFDAVVVDTEKTSLDCVQYLKDQRFPPITFIPLDNIKVNTSNSAVKGIHGARLTIDTVDFDPSLERAIAYACGGSVVCDTLEIAKDIVYNRKIPVKAVTLQGYVIHKTGQMSGGRLPEGKGGSRRFEEQEIENLQRMAEKLKDDIAKLPPPSRRSIAEETLQNDLVALEQRLRIQQSELVAFEKNLTSKQKELDNAKRQLKEYEPKFAEKEGELQRTRATVEKFEKAIAEVEDKIFASFCKRLGYENIRAYEAQQGSLEQEATQKRQEFNLQKQRIQNSLAWETSQFNSFNDRLRDLEAAIKRNQRDLESYKREKEEIEKARGEDLDELEALQETLVEVKSDYTEKSDRVAEIKQGLDKRRREIEGRLKEISNLEAVVHKNSQDKFALLRRCKLEQIKIPLKTGSLDDLPNEEALLQRDQDAMDVDGEVDEDGMLEAAMDNYGIEVDFDKLEDNLKEDDDSVERQLQAKIDELTAQLEKLNPNLRAMDRLDHVRKQLEQTEQEFEASKAKLRQARESFQAVKQKRLELFNKAFTHIQEQITHVYKELTRSEAYPLGGQAYLDIEEDTDTPFLSGVKYHAMPPLKRFRDMEHLSGGEKTMAALALLFAIHSYQPSPFFVLDEVDAALDNANVEKIKKYIREHAGPGMQFIVISLKPALFQASESLIGVYRDQEANTSRTLTLDLRKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGN1</accession>
    <name>G0SGN1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0066930</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696988.1">
        <property type="nucleotide sequence ID" value="XM_006696925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGN1"/>
    <dbReference type="GeneID" id="18260731"/>
    <dbReference type="KEGG" id="cthr:CTHT_0066930"/>
    <dbReference type="HOGENOM" id="CLU_1234866_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="224" mass="23636" checksum="F552454181B5E3B1" modified="2011-10-19" version="1">MSRRVALSVPSPSSSSPTECPTAPRTLGDDTDGTSPNPLYTAPLSRHLSSRLQPCGRSPYDHQPEPEPLVCVVVESTLLPRLLATLPDEASLLPTEEEGRYPGMRLDVGVRLWSESLRPLRTPETTPFPVLLATDTIGTPPDPTTKLAADPGLEGGCTPVYGVVDPLPSLLLDELGLEEEVNWVSLALGPGTGIPGEVSWKGKLAVARTGAVEGCVTVLGEADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGN5</accession>
    <name>G0SGN5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0066990</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696992.1">
        <property type="nucleotide sequence ID" value="XM_006696929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGN5"/>
    <dbReference type="STRING" id="759272.G0SGN5"/>
    <dbReference type="GeneID" id="18260737"/>
    <dbReference type="KEGG" id="cthr:CTHT_0066990"/>
    <dbReference type="eggNOG" id="ENOG502T2EZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015357_0_0_1"/>
    <dbReference type="OMA" id="FADMKQV"/>
    <dbReference type="OrthoDB" id="5428925at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144284">
        <property type="entry name" value="Sec2 N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="339"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="422"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="653"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="586"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="660"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="685"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="772"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="801" mass="86504" checksum="2FB760BFF46321D1" modified="2011-10-19" version="1">MPSLFGKSGSTLGRAKSRHKSIRGTISAPIPIPTSPVGGDFPFQNRMSIKTTVTADDDLLTRRPGTGATPPGPVNDGPKPDEPSVQSDLHRSEDLPAPRTRDGSASSGGVSASRSNAPDEKPSTPPQPLGAGEALQRTPSRSPSRKSLQRRTSPARTSPSGVSAPAGRATNPALSSTVRYSVISDTPSKQTTQGTPVRKKSTFRSALEKIFGRGRKKSNEMDPTPPNLTQHAQHAQHRSVSHDLGPEGYKTTDSLQDPSALVRPAAPSPKRSASAPISEYDRPLRSHSIGPEDIMMIESARNSLHADAAGIATAQPAEQTRRRAATTGNPLLFRPHLHNQEWGHGLSPRPASAQGRRSRLGIQTDLEDPSEIGRAITSDSGHGTRRRSRSLSGLQDLASMQSHSRRRSDEIRYWRESYDPGFTSPISSNIQGDIDDTAAGDPSAPVSPTTDRAPRSPPQPPFSFGTVKEEEAAAEDPAPQEEVPIETRVVGLEARTAHLEQLVDKLSRLVPGFDDAAQHHIDLDARSQVSIGEAATNPGSRASPRGGQSPRLPFSPAFNPVVRGASSLPILGGQKHYHSLNRDEVIAELRNELEAERAARQVLEAQVKKLSERVNTLSTTMFAMVRGPSETRLQERLGPPAQAAKVVPISPLPLPRKVTVPRPVRQIPVQQQHQQEEATRSVFESSDEDDETDTEDEGTPNTKRPYTLSLSTTTASRAVARGDGREQETAAAAAAEEEEEEEYQTPKEEARVPRGAFGEVLRDDYDDGDNGEGQKGEGEEKRKKAARTLSLSQLTMRRRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGN6</accession>
    <name>G0SGN6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0067000</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696993.1">
        <property type="nucleotide sequence ID" value="XM_006696930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGN6"/>
    <dbReference type="GeneID" id="18260738"/>
    <dbReference type="KEGG" id="cthr:CTHT_0067000"/>
    <dbReference type="eggNOG" id="KOG1803">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001666_8_2_1"/>
    <dbReference type="OMA" id="SGCEFYE"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18044">
        <property type="entry name" value="DEXXQc_SMUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
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        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
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        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048761">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21138">
        <property type="entry name" value="SMUBP-2_HCS1_1B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="410"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="428"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="720"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS17375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="890" mass="97113" checksum="38788DD8BC363615" modified="2011-10-19" version="1">MTNTTTTTTSPRDLNTSRSSTSLSPQSTGRLPKHQSSRDRIEQILEGARERAESLDQTDPGSINPGLRPLLASSPSPHTALPPDLDDSHHGGGYASESIVTTQPTRQPSLNYLSTAQTAPNSTRRRSIQPKKSFTTAGVERQDQAPSQPLVASGAAGCDSGDSQSMRGSTNTGQKEESRWKRTLRYFKSIELENKGSVARDHLALAEVQAEIEESSALVSLHSPSALQRAGVALTNLTILSQRTGLGGKTVLELGPDPAFTISTSELPEHAIRVGDIVLVSELHAQSGIKTTKRGKTKGLAGGDGGSGGGEKQTGVKGVVTKVGKGTVCVAVEEEDAERGEERIPEGRCWIVKVADDVTYRRMSQTMDKLAKMSEAEYTPFIRVLFGLSSPSPVPEDLSKDPEVGNIEWFDKTLNDSQKDAIRFALASKEIALIHGPPGTGKTHTLIELILQLLSRNLRILVCGPSNISVDNIVERLAPHQIPLIRLGHPARLLPSILPYSLDILTRTSDASAIVQDIRSEMDTLQSSIRKTRSGRERRAIYAQLKDLRKEYRERERRCVDELIKGSKVVLATLHGAGGFQLRQEQFDVVIIDEASQALEAQCWVALLAAKKAVCAGDHLQLPPTIKSLNSSKGASAKKGGPSLETTLFDRLLALHGSGIKRMLTTQYRMHEKIMRFPSDELYDGKLVAAPRVGDRLLKDLPYGVEETDETTEPLIFIDTQGGDFPEKNEDDSDQQDGSKKKLTKGMIYSESKSNEMEAALVRQHVRKLVEAGVKAEDIAVVTPYNAQLAILAPLKDEFPGIELGSVDGFQGREKEAVIVSLVRSNPDGEVGFLGEKRRLNVAMTRPKRSLTVIGDSETVKKGSKFLKNWMEFLEENADLRYPDLASLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGY8</accession>
    <name>G0SGY8_CHATD</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0068040</name>
    </gene>
    <organism evidence="4">
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        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006697032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGY8"/>
    <dbReference type="STRING" id="759272.G0SGY8"/>
    <dbReference type="GeneID" id="18260842"/>
    <dbReference type="KEGG" id="cthr:CTHT_0068040"/>
    <dbReference type="eggNOG" id="ENOG502QQEE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_351239_0_0_1"/>
    <dbReference type="OrthoDB" id="3553547at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="15"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="579"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="628"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="757"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="348"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="579"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="677"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="801" mass="90166" checksum="4C3C7A8E9932A68A" modified="2011-10-19" version="1">MDPFFIPPVYPPLPVRPIPPPPPPPPPQPPPLSDSCASMQLHENTSDGPYHEDRKIRYPSPQDTRCTSPAVALIQPGPTKPRIPSIWFRVAGLVAFVVVKLLGVRRRAKRHKIWELRRVMAARREELRSLRREKDLADNGFMQAVRERLITEGEFVILPVKEIQQHFERMQAARNVYCSAELAYEAMEQELETEEQELTRMETSLPALHGDPLARHPTAVQGDNSLNDQAQEENSSAKDQSSLRTPDILLGISAELEDDIHPLYGQLLDAAAKLNSAEDFCEEIEVDRERLLSDLERQFLLRKHLTGDNVTDDDLKSFRSSLVNIPDTMKEFEARFGLSINQGDYEFLRDYESLAKEAREKVDQASRRLTYLRELCLSKGVMRKHPTFQEEVAIFSNVPDWSPHPDDGMIDIGPTHHLLHSHLQRAQPAHDPFKTSPGSVKPSALAHPLFSILMSNPTYILQLLSPIKALARVLALPKTDPTTAQLRAECMKEIGILKLMKASVKNKVDFVNQWLMHRVRTCRLECMVLLATTQLVFQKASRRLTNLRRWQEEVLYWWPKDGAAHGSYWDEWHGSLPVSSDSQEQSVKSCMENNSVGMPEKDKRTDDGTITYDSLLSSFMALSSAIQVERTEERADDVPTAIPSPTDPNHSGDRRVADNSSPSSVMASPIAIREEQTNVSTEHALTSGHTHHNDNDRNVTNSSPASSVKPPHPVIQDEERTEITAQHVETPAAAVGNLQNELSGTENGYSDVGSSIKKTNPDADQHQGIAGRHGQHNPPPDFHLRKLWRSVARIVRSAFQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0SH17</accession>
    <name>G0SH17_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">O-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0068350</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Sterol O-acyltransferase that catalyzes the formation of stery esters.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697124.1">
        <property type="nucleotide sequence ID" value="XM_006697061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SH17"/>
    <dbReference type="STRING" id="759272.G0SH17"/>
    <dbReference type="GeneID" id="18260873"/>
    <dbReference type="KEGG" id="cthr:CTHT_0068350"/>
    <dbReference type="eggNOG" id="KOG0380">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018190_2_0_1"/>
    <dbReference type="OMA" id="FICQMLQ"/>
    <dbReference type="OrthoDB" id="10039049at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034737">
        <property type="term" value="F:ergosterol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008204">
        <property type="term" value="P:ergosterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF9">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000439">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="412"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="543"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="27"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000439-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS17506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="566" mass="64421" checksum="7BCBA661981A4FA8" modified="2011-10-19" version="1">MATTAAEISEEPSVRKLRSRAQKRPLLQSQLSHSSTASESNGVEATSNGHVTPQASGYSTPIPSDAPPSVKSLSTVRKQVRAEQRRRLFPTVEFASRVSHFDPNSDHRDFHGFFNLFWIGLAIMAITTMLRNIKDTGYPFRVQIWSLFTVKLWHLAIADFLMVFSTAVSLPLHRLFRAAPANSVLTWARGGIVIMSIYQVLWLSVWIAVPFLLEWTWTAQVFLLLHTMVLLMKMHSYAFYNGHLSETEKRLRALDNPATASRAPAYLYPTLENPMGSLAGAITTTSSPKSRPGDDDAEEVAQLREVLARELTSPMGNITYPTNLTWSNYFDYLCCPTLCYELEYPRNERIDWQNLFSKILATFGCIFLLTVISEEFILPALIDAQNRLNPASRPASSPLTALEVLLILAETISWLLFPFMLTFLLVFLVIFEYVLGACAEMTRFADRHFYSDWWNSTDWMEFSREWNVPVYSFLRRHVYSASRPYIGKANATVITFLISAIGHEIVMACITKKLRGYGFVCQMLQLPIVMLQRTKWVRGRKTFNNVCFWCSMILGLSLICSLYVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0SH94</accession>
    <name>G0SH94_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0069180</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697201.1">
        <property type="nucleotide sequence ID" value="XM_006697138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SH94"/>
    <dbReference type="GeneID" id="18260956"/>
    <dbReference type="KEGG" id="cthr:CTHT_0069180"/>
    <dbReference type="eggNOG" id="ENOG502S025">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_0_4_1"/>
    <dbReference type="OMA" id="INATPQW"/>
    <dbReference type="OrthoDB" id="3648173at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="36"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="284"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS17583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="449" mass="49337" checksum="22EA7CDC7951FC0A" modified="2011-10-19" version="1">MPGTSPNPALDGESRVTEIIAILSVTTTLSTLIVVLRCYTRAFILKSFGPDDVVMVPAQALTIAAAVAIGLETKYGLGRHYWTVPDEHYIPYMKAFYSSIIVYNIAVCLTKISILLLYRRVFSNTTLNKILLVGLMFLSAWGITLCFLLPLVCVPVSAFWDPTHNTGHCLNSQTIWQKLLLLCVFTMGVFPCAVAIYRIHTLYDLSQSSDDPTWDNVDAATFSMLELTVGIMATCLPTIRPILIRALPKIFASNGSLNVLPSSHGNNGRSGVANSRFSRRDARTGFKGLHSNPSRSPSRPPSPYKLNSDGGRDSASNGRLGLHSSISNEALHSYHDSRKADDLGPLSIFPRNLRESDHDIEMVGELKAAPVSSVDRLYSVSVVGGYELRDAKKQNKKHDQELNPALRGITTTTIVTQHISFTGESLEDIGIDYPMGTRQRPVLKRVLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHF9</accession>
    <name>G0SHF9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Potassium transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0069880</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697266.1">
        <property type="nucleotide sequence ID" value="XM_006697203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHF9"/>
    <dbReference type="STRING" id="759272.G0SHF9"/>
    <dbReference type="GeneID" id="18261026"/>
    <dbReference type="KEGG" id="cthr:CTHT_0069880"/>
    <dbReference type="eggNOG" id="KOG1341">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005947_0_1_1"/>
    <dbReference type="OMA" id="RMTNDGI"/>
    <dbReference type="OrthoDB" id="9999863at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004773">
        <property type="entry name" value="K/Na_transp_Trk1/HKT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00934">
        <property type="entry name" value="2a38euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF30">
        <property type="entry name" value="HIGH-AFFINITY POTASSIUM TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="471"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="560"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="684"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="713"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="740"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="162"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="880"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="927"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="892"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS17648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="970" mass="107354" checksum="6B08FBE017C20AED" modified="2011-10-19" version="1">MGSFKDWVVGQIKGLRPSFMSHKPHFNFITAHYFYILGLTFIGSILLFAGGRGNISYTDALFFGACASTQAGLNVVDINKLNTFQQIVIYIIPMLANPITINSFVVFLRLYWFEKRFQHIVQESRLRRGTISRAKSKAKSLPGDLEKGVNGRKITVMLNGHRSRMTPDGTLLEDDPVPSEKSKLERRASDPLSRTSSSWKIESDAHRHPDIKFSRTVTKSDGMSDDVLKLPPLRSEQEHIAILERQRKDDDEVLRIPNPRDVERGVLPKRVVAGEDDEPDPLSPARGEFSHDVCDEPQHLTFDGRQQAITIEEPDRRKLEQSGSDDSLIDARAAVRALSWFRIPLPRFLKRGKARLHDNKHPAGLASAALKGRRRSLQTLRTVLSRDKVEGTPYLSWEPTIGRNSAFPDLTEEQREELGGIEYRSLKTLAVILVCYFWVFSILGVIGLLPWILHVQKYGQVVTAAGVSKVWWAFFTANSAFMDLGFTLTPDSMNSFNTATWPLLFMSFLIIIGNTGFPIMLRFIIWSLSLVTSVGTGLYEELRFLLDHPRRCFTLLFPSAATWWLFGVLIVLNVVDVILFIVLDLGAEPVIALSPGLKVLNGLFEAVSTRTAGFSSVNLGLLHPAVQSSYMIMMYISVFPIAISVRRTNVYEEQSLGVYTPYDLDDQGNQSDMSYVGTHLRRQLSFDLWYIFVGFFILNITEGSKLMANRFSGFAILFEVVSAYGTVGMSLGYSGGNESLSSQFSVIGKLVIIAMMIRGRHRGLPYGLDRAILLPSESLSATEASAPAPISVEPEIPRISRLYSRTSAVTGGPDIGSSARHKSFTSADPRNLLASILHPGPPLPSMGPAETIRRAESIRRMSIDPSLVSGLERLERQKSATTTFSQLPQDPAGASGAGASAAGDATAEVTSTAATSGTDYLHVDQQPWVTRITSRRTEPGASTSRRDRGRGESISSLSAIQRPKTSGPVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHL8</accession>
    <name>G0SHL8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Voltage-gated chloride channel-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0070490</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697325.1">
        <property type="nucleotide sequence ID" value="XM_006697262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHL8"/>
    <dbReference type="GeneID" id="18261087"/>
    <dbReference type="KEGG" id="cthr:CTHT_0070490"/>
    <dbReference type="eggNOG" id="KOG0475">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003181_2_0_1"/>
    <dbReference type="OMA" id="TDWVHDT"/>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000013">
        <property type="entry name" value="Voltage-gated chloride channel (ClcA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF3">
        <property type="entry name" value="CLC CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0868">Chloride</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="408"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="524"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="583"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="610"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS17707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="898" mass="99078" checksum="CF64CCDE776B97AC" modified="2011-10-19" version="1">MAGRQGPRLEIREDDGAPDASNNTYGTYLSLPNSPTNTRRPTMSRRPSTGDGPDERSPLLTGSRTSRIRIHSAHGSPRVPILSRNQSYADSVKSTRHHSRANSWGSRLMNAFSDRQNNDRPDLADSHGSLFFPDDRVWYDQFTSTDWVHDTIADSYRQKALRSRKDFWGRVYLLFDGAQGWILSALVGFVVAVLAYVINVSEATVFDFKDGYCRRGWFISEKKCCPHGPCTDWRDWGEVLQGWPFGERWTEYAVYIAAVITLACLSCLLTLTTKTVVPSAYRLSTLDENLAADPATPPDSDAGTETSPVRSSPIVPKEHPAASPPMIYYSAAGSGVAEVRVILSGFVLHGFLGLKTLIIKSMGLILSVASGLSLGKEGPYVHIATCVGNIACRLFSKYDRNDAKRREVLSAAAAAGVAVAFGAPLGGVLFGLEEVAYFFPAKTLFRTFFCCITAALTLKFLNPYGTHKIVMFQVRYLVDWEYFEILSFIIVGVLGGAAGALFIKASRRWAKTFRKIPMIKKYPMLEVMLVALVTGLVSYWNVFTKLPVAKLLYNLAAPCDDRDQNLEDLGLCPTEKGDIPPALANLLAAFLIKGLLTIITFGIKVPAGIYVPSMVVGGLMGRFCGHVVQWVVMATPNFGLWGTCGRMPGTCIQPGVYGLIAAGSTMCGVTRLSVTLAVILFELTGSLDYVLPFSLAILVAKWTADFIEPLSIYDLLTEMNSYPYLNNKHKPIFTSELADIIPRTIRPHRIIDITNSPLVAAPTLRHKLELLHRAGELDGGLPIVRDGILVGLIPAPDLEYALDQLPDEENSLCLMAPVQSIEEDDEAGEDPTDFTPYIDPAPVALDIRSPMDLVYECFAKLGLRYICVVRDGRYAGMCHKKTFVKYMREVEEKERHML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHV3</accession>
    <name>G0SHV3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0073490</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697605.1">
        <property type="nucleotide sequence ID" value="XM_006697542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHV3"/>
    <dbReference type="GeneID" id="18261387"/>
    <dbReference type="KEGG" id="cthr:CTHT_0073490"/>
    <dbReference type="HOGENOM" id="CLU_2558113_0_0_1"/>
    <dbReference type="OrthoDB" id="4587286at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS17023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="82" mass="8870" checksum="3E21E3F281B7BBFE" modified="2011-10-19" version="1">MAINSSLSALSSWLRPEQPAYRPLEPLSAAFGGIKKPVAELVITFVDEKPKPKKAAYVPSHAASSFLKTATSRPMRQANGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHX4</accession>
    <name>G0SHX4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Isoleucine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CTHT_0073700</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="3"/>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697626.1">
        <property type="nucleotide sequence ID" value="XM_006697563.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0SHX4"/>
    <dbReference type="GeneID" id="18261408"/>
    <dbReference type="KEGG" id="cthr:CTHT_0073700"/>
    <dbReference type="eggNOG" id="KOG0433">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3028">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001493_7_2_1"/>
    <dbReference type="OMA" id="HCWRCKT"/>
    <dbReference type="OrthoDB" id="10264412at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07960">
        <property type="entry name" value="Anticodon_Ia_Ile_BEm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03078">
        <property type="entry name" value="GST_N_Metaxin1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000111">
        <property type="entry name" value="Mitochondrial isoleucyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.830">
        <property type="entry name" value="Ile-tRNA synthetase CP2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033708">
        <property type="entry name" value="Anticodon_Ile_BEm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050081">
        <property type="entry name" value="Ile-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019564">
        <property type="entry name" value="Sam37/metaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10568">
        <property type="entry name" value="Tom37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 17" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial outer membrane transport complex Sam37/metaxin N-terminal" evidence="16">
        <location>
            <begin position="21"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="14">
        <location>
            <begin position="437"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="15">
        <location>
            <begin position="1122"/>
            <end position="1268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF10568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGS17044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1375" mass="152492" checksum="EE77B34BAE5DC816" modified="2011-10-19" version="1">MVLQLHVWGPAFGLPSLDAECLAVIAFVTQTISPFDYELIASSPSAVPTQHLPALYDPKTSTWTTGFSPIIRHLRAHPPPSYAPPPNLPPDVDPAKVAADNTAYTAFLTAHAAPLLALSLYVSSANYAASTRPAYSSILPFPLPWTEPPNVRAAMSRRAAHLGITGLDTDAEDEGKSETSLGKEEWVNATVPASLRKGLEVKRKGVVGMLAPEAKRRIRLEGAAKDVLDVLDEVDWTGPSVQMLEVRCLAWGYLALMALPDVPRGWLGEVLRRDYPRLIRFVEEFRELVFVKGPGSDLPWATEWHESRSAGAVLVRFVRGVLGEVPVLGELWRAWWTERMRAVMLGERAVRTMERDRRKGGVLMLLGAGLMAAVVGVGVWWYRSLPPFGEAVQVWRRPVASLSSFGAAGALFSGALYGIPRPLPQHRDQYIQRCADELYAWQAANRPADNEFILHDGPPYANGALHAGHALNKILKDMILRVQVQKGRRVHYVPGWDCHGLPIELKAVDAAAGKHMTPAAIRQAARKLAADTILQQMKSFRSYAVMADWDARWATMDREYEIRQLRLFQKMARRGLVYRRFKPVYWSPSSGTALAEAELEYNENHVSRSAYIRFPIVGDYGNLPGLEGFQGKLYAVIWTTTPWTLPANRAIAVHEDLTYHIVKVDGDAYLVAENCLGRVAKILIKEGEEGAEVAAPEILGSVKGRQLTQLCYVNALRGRSAAPQPIIHGHFVTEASGSGLVHCAPGHGFDDYQACLPLDIPVDAPVDNDGLFTEEAYPDDPARLKGRSVLEDGGPAVLEILGDDVLKVHDYKHKYPYDWRTKKPIIIRATAQWFADVELIKNQAVAALEEVKFVPESGKNRLESFVKGRSEWCISRQRAWGVPIPALYEPNGNAVMTDEVMDHLIKVIEERGIDAWWTDALDDPAWLPESLRSSGIKYTRGLDTMDVWFDSGSSWTMLNNQQADLYLEGSDQARGWFQSSLLTRVAAMVEQQDSASGSTAHTLGLSPFKTLITHGFTLDKEGRKMSKSLGNVISADDVMDGTLMPPLKPRKGSNNSQPIKDALGPDALRLWVASSDYSGDVVLGEPVLKTIHQAILKYRTTIRMLTGSMHESARTAPLTTLDHIALIQLRDAMDAVGRHYANFEFNKAFMTLNHWLTNDLSAFYLEALKDRLYCADGGGVLEPIFIGFLRMLAPMTPVLVEEAWEHRPEWLKADSKYADSPLKHLYEAPLLHDPSRALSPEDEARLRKDIPVIMRSLAAIKAASEKARTDKVLGSSLACNVVLHVPEGSRAREALERYAGELDTMFVVSAVEVGGEVPADVAWKYEEVFEIEGTECKAVVIPPRQVKCPRCWRYVAEKEDVLCGRCEEVVGENVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHY1</accession>
    <name>G0SHY1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0073780</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697633.1">
        <property type="nucleotide sequence ID" value="XM_006697570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHY1"/>
    <dbReference type="GeneID" id="18261416"/>
    <dbReference type="KEGG" id="cthr:CTHT_0073780"/>
    <dbReference type="eggNOG" id="KOG2819">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032056_3_0_1"/>
    <dbReference type="OMA" id="YRKNDQK"/>
    <dbReference type="OrthoDB" id="411211at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005373">
        <property type="entry name" value="PHAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039156">
        <property type="entry name" value="PHAF1/BROMI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465:SF2">
        <property type="entry name" value="PHAGOSOME ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465">
        <property type="entry name" value="UPF0183 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03676">
        <property type="entry name" value="PHAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="276"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="352"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="524" mass="58225" checksum="00E1E3165CD193AB" modified="2011-10-19" version="1">MSLFSAQLHPGRALGFLVLGASLHDVLTRLKAEPQRFPKMELMYPPDDPIHGQIVVVLPTNGIRLRFDGPEQRLRLIEVLNFTKNHIFLKPANDKERDLVRPSSTTSYDGDASAGPTFRHIYQRFLGPTYDGEYLPDSETYVLSYPGVAFSFPMRRQDYSPTKDVVSLLSANAVPTSMAVFSGDSWAHARETMWTEVLPSVKAFAPMAKGKDLCPDEVSLVKIHGGGKLQLFRKWTNNSFWITLGETTPQQLVAELGPPDAIYRKNDQRMYIHKLRAHSNTTNNRPNLNDLKRGDDLTDTDLSSHPPSDEYDDSSSNDGSNSEAIEDDPDGPSEECFYNYFYLGFDVLVSTPTLPSPPPPGQESHTPDSSSNPSSPVKLTSPDRLVATKVILHGNVPGSYPFNRHRRIRWEISYLPGPTPANSETPFPQIEERLRERWKSAYPSDGELKQQRGMVLNRGWGDSPGSSCEFLGGWEESVGGVRNGDDVGVNGGRLTGMMTTTLFGFPGLVFEVMRGGWVSAVTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHY3</accession>
    <name>G0SHY3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative recessive suppressor of secretory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0073800</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697635.1">
        <property type="nucleotide sequence ID" value="XM_006697572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHY3"/>
    <dbReference type="STRING" id="759272.G0SHY3"/>
    <dbReference type="GeneID" id="18261418"/>
    <dbReference type="KEGG" id="cthr:CTHT_0073800"/>
    <dbReference type="eggNOG" id="KOG1889">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003016_7_4_1"/>
    <dbReference type="OMA" id="ITKAQPV"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF2">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="604"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="637"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="SAC" evidence="2">
        <location>
            <begin position="118"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="718" mass="80859" checksum="1390C49D7C2BAE56" modified="2011-10-19" version="1">MALPFRDVNVQHASDSYIFSSPSSPNAPALLIDRPTGDIRLSDASLLAGKRVSRVTSIAGILGVIRLRLDKYVVLITKAKPVGKLCGHTVYKVVATELLPLRERQISDPDEDRFLALLRGFIRDGPMYFSYTLDLTNSFQRQAQQDAAVPLWKRADDRFFWNRFLQSDLINFRNQGARGFPAPQPGIDPYILPVIFGMLEIHPTTFSGTPLTLALITRRSRYRAGTRYFTRGLDEEGHAANYNETEQILVLNDNNASGYASGAGTSKAGEHKEMQILSYVQTRGSVPAFWAEINTLKYTPKLQIRAIEAAYPAARAHFEEQVRLYGDNYLVNLVNQKGREMPVKHAYEKMVQMLTNNTGVEHIQADQHTDEKFRTIETAGNSRSSIANRLHYIYFDFHAETKGLQMHRAQLLIDRMRDALLAQQYFRAVDMPGSRQLSAAPGLPRLEIRSLQTSVVRTNCMDCLDRTNVVQSLLARWTLDRMLSDLGLLPRGARFADADPAFENLFRNIWADNADVVSKAYSGTGAMKTDLTRTGKRTKAGALQDLRVALTRYCKNNFTDGPRQDAFDLFLGEYVPVAAGTPSISVMGGGGIGGYDVFADRRPVWIQAVPYIAAFGAFFVMVALYTPRVSDKAIWPLRLATIFWALVAVWGFWFVMSNGMLYVNWPKLNPRPWATEGYHETIRRVRKDRILGPLVARHERGLSTARYVNAEEGKKRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0SI18</accession>
    <name>G0SI18_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0074170</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697670.1">
        <property type="nucleotide sequence ID" value="XM_006697607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SI18"/>
    <dbReference type="STRING" id="759272.G0SI18"/>
    <dbReference type="GeneID" id="18261455"/>
    <dbReference type="KEGG" id="cthr:CTHT_0074170"/>
    <dbReference type="eggNOG" id="KOG0742">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004471_6_2_1"/>
    <dbReference type="OMA" id="LHRNAMV"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF2">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="699"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="927" mass="105134" checksum="AC54937D0FD82667" modified="2011-10-19" version="1">MLLQPAILALLPRQPITTQFLIPDYPRHLNAINPASRQPVPSSQRCWSGACMCSLLHEVPRRARGWSPVNVYIIMAPGIVSEEAAPAVVAATNGVAADEPKKAEDVVNGVKAGISSEPNGELVNGITTEKAAETADVSEKSKEDAANGAETSHISDSASIKKDEKSAETKTDDDKAEEKKDEEKKEPAKPQQVLVTLEVNPANGNVVVKEAKAKPPSQNFLLTLEVDPNGEVIVKKTKPDKKKDEAKSDSKVDDTKKDADKEKGNEKEKDNTMKYEIKYLDRKYDDKDEPYFTERKTEEKQTEKSQPDWWQLYAFCIVRHYDYSNESVETTSMYVNAPQLRKLLADVIGNYPGHPIDEDEVQISAPYWPLFHYRKQIEEEGMKRFADNEQARKGLTLLLEWIDTHFKDEFAALERCLSHEHHAIAYEHLWTLYPPNTIIYCKILNQNRAFRLNSCWYGCEPSFVARMEYVDFDGERIGLRHWELDISAYQGALEVADMTFMPFNLLEDADEVREELLTRGRKFEEYAHSQPKFMAYDAVALKRTHNGYAKLSVNGRVMVDPKTFHRMDTSDSFRVAPIGEPGKKDRGRSKRRRCCAPTIPYFAGDEDNEGKHGNEHKREYEKLNDEDIMLANATIRGYSFAQKVFLEFYVDELKEIEWNTKCFDGLVLDPTVKKTVQALVSMHNKRRDAFDDIVKGKGKGLVCVLHGPPGVGKTLTAECVAEFVKRPLYMVSSGDLGTCSADLDRKLTQIMDLASTWRAVLLIDEADVFLEQRALHDLHRNAMVSVFLRVLEYYSGILFLTTNRVSTFDDAFKSRIHIPIRYTELTVESRMQIWRNFCNDVPGGVDIDEKGLRRLAEIDLNGRQIKNAIKAAEGLAAFDGVKVDLEQLLQVTKIQEMFEKDLTSVNGIDYTAPGSSKKNAESRHMFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G1DJA8</accession>
    <name>G1DJA8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">ATP synthase protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CTHT_m000490</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="16"/>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14 15">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 15">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Mitochondrion inner membrane</location>
            <topology evidence="15">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the ATPase protein 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="JN007486">
        <property type="protein sequence ID" value="AEI26016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004769789.1">
        <property type="nucleotide sequence ID" value="NC_015893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G1DJA8"/>
    <dbReference type="STRING" id="759272.G1DJA8"/>
    <dbReference type="GeneID" id="11030336"/>
    <dbReference type="KEGG" id="cthr:CTHT_m000490"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009230">
        <property type="entry name" value="ATP_synth_su8_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36101">
        <property type="entry name" value="ATP SYNTHASE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36101:SF1">
        <property type="entry name" value="ATP SYNTHASE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05933">
        <property type="entry name" value="Fun_ATP-synt_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 15" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6 15" id="KW-0138">CF(0)</keyword>
    <keyword evidence="8 15" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 15 16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AEI26016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="55" mass="6530" checksum="3167F796911D01A6" modified="2011-10-19" version="1">MPQLVPFYFVNEITFTFAIIAINVYILSKYILPRFVRLFLSRTFISKLLDNSINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0RXT4</accession>
    <name>G0RXT4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DM2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0000310</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988030">
        <property type="protein sequence ID" value="EGS24100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690586.1">
        <property type="nucleotide sequence ID" value="XM_006690523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RXT4"/>
    <dbReference type="STRING" id="759272.G0RXT4"/>
    <dbReference type="GeneID" id="18254069"/>
    <dbReference type="KEGG" id="cthr:CTHT_0000310"/>
    <dbReference type="eggNOG" id="KOG1946">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046065_1_1_1"/>
    <dbReference type="OMA" id="RYTRIID"/>
    <dbReference type="OrthoDB" id="10251073at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000500">
        <property type="term" value="C:RNA polymerase I upstream activating factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10567">
        <property type="entry name" value="SWIB-MDM2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.245.10:FF:000004">
        <property type="entry name" value="Upstream activation factor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DM2" evidence="6">
        <location>
            <begin position="160"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="40"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS24100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="240" mass="26591" checksum="AEFC3351D7828A3D" modified="2011-10-19" version="1">MSTQLTEDERERYTRIIDDLIHKADLETVTQLIEARFDAISGVQQQPTPEEANGAGSPESASANGDGEPTAKKRKRETSSIEDADARLAAELQAQENSLARQRVTRGANKAKGKAANSKAADKGKKGKAKKSAKRVRDEDDSEAGSGDDGEKPKRKAGGGFQKPFNLSYPLQELTGETQLSRPQVVKKLWDYIKEKDLQDPNDKRQIICDSKLQAIFKQEKINMFSMNKLLGNQLYPIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>G0RY15</accession>
    <name>G0RY15_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenylate kinase</fullName>
            <ecNumber evidence="6">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate kinase cytosolic and mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ADK1</name>
        <name evidence="9" type="ORF">CTHT_0005050</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <text evidence="6">Predominantly mitochondrial.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the adenylate kinase family. AK2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6"/>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691043.1">
        <property type="nucleotide sequence ID" value="XM_006690980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RY15"/>
    <dbReference type="STRING" id="759272.G0RY15"/>
    <dbReference type="GeneID" id="18254543"/>
    <dbReference type="KEGG" id="cthr:CTHT_0005050"/>
    <dbReference type="eggNOG" id="KOG3078">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032354_1_0_1"/>
    <dbReference type="OMA" id="HYKVDAA"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006172">
        <property type="term" value="P:ADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03168">
        <property type="entry name" value="Adenylate_kinase_AK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028587">
        <property type="entry name" value="AK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001380">
        <property type="entry name" value="PRK00279.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001381">
        <property type="entry name" value="PRK00279.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011100">
        <property type="entry name" value="PRK14527.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="8">
        <location>
            <begin position="171"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMPbind" evidence="6">
        <location>
            <begin position="73"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="6">
        <location>
            <begin position="170"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="53"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="100"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="180"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS23801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="274" mass="30095" checksum="433D0A307887A6E6" modified="2011-10-19" version="1">MGYLEDEVKRLQGIIANIESRVKALEERQFGQQAQKKPVEDNTVRMILIGPPGAGKGTQAPKIKEKFNCCHLATGDMLRSQVAKKTPLGLEAKKIMDAGGLVSDEIVINMIKEELNNNPSCKGGFILDGFPRTVPQAEGLDKMLRERNQALQHAIELKIDDELLVSRITGRLIHPGSGRSYHVTFNPPKVPGKDDITGEPLVQRSDDNAEALKKRLATYHKQTTPVVEYYKKTGIWKAVDAAQEPNQVWKSLLAIFDGEKAKSASASGKLAASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYB3</accession>
    <name>G0RYB3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mitochondrial heat shock protein 60-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0006080</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2023-06" db="PDB data bank">
            <title>Symmetry expanded D7, locally refined cryo-EM map of mitochondrial heat shock protein 60-like protein Chaetomium thermophilum.</title>
            <authorList>
                <person name="Semchonok D.A."/>
                <person name="Kyrilis F.L."/>
                <person name="Hamdi F."/>
                <person name="Kastritis P.L."/>
            </authorList>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.46 ANGSTROMS)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691141.1">
        <property type="nucleotide sequence ID" value="XM_006691078.1"/>
    </dbReference>
    <dbReference type="PDB" id="8PE8">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.46 A"/>
        <property type="chains" value="A/B/C/D/E/F/G/H/I/J/K/L/M/N=1-575"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYB3"/>
    <dbReference type="EMDB" id="EMD-17629"/>
    <dbReference type="SMR" id="G0RYB3"/>
    <dbReference type="STRING" id="759272.G0RYB3"/>
    <dbReference type="GeneID" id="18254646"/>
    <dbReference type="KEGG" id="cthr:CTHT_0006080"/>
    <dbReference type="eggNOG" id="KOG0356">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016503_3_0_1"/>
    <dbReference type="OMA" id="TDTDKME"/>
    <dbReference type="OrthoDB" id="1733909at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000001">
        <property type="entry name" value="60 kDa chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000001">
        <property type="entry name" value="60 kDa chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000592">
        <property type="entry name" value="PRK00013.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009487">
        <property type="entry name" value="PRK12849.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009488">
        <property type="entry name" value="PRK12850.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009489">
        <property type="entry name" value="PRK12851.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45633">
        <property type="entry name" value="60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS23899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="8PE8"/>
        </source>
    </evidence>
    <sequence length="575" mass="60599" checksum="6AFD41BCE4F0E452" modified="2011-10-19" version="1">MQRALTRASVSSPLATARVRSAQQLRFAHKELKFGVEGRAALLNGVETLAKAVATTLGPKGRNVLIESTFGSPKITKDGVTVAKAISLKDKFENLGAKLLAEVASKTNEVAGDGTTTATVLARAIFSEMVKNVAAGCNPMDLRRGIQAAVDAVVEYLQQNKRDITTSAEIAQVATISANGDQHIGKLIASAMEKVGKEGVITVKEGKTLQDELEVTEGMRFDRGFVSPYFITDAKAQKVEFEKPLILLSEQKISAATDIIPALEISHKMRRPLVIIAEDIDGEALAVCILNKLRGQLEVAAVKAPGFGDNRKSILGDIAVLTNGTVFTNELDVKLEKVTPDMLGSTGSITITKEDTIILNGDGSKDAIAQRCEQIRGAMNDPSTSEYEKEKLQERLAKLSGGVAVIKVGGSSEVEVGEKKDRFVDALNATRAAVEEGILPGGGTALIKASVNALNNLKPANFDQQLGVNIIKNAITRPARMIVENAGLEGSVVIGKISDEYAADFNKGFNSATGEYVDMIQAGILDPLKVVRTGLIDASGVASLLGTTEVAIVEAPEEKGPAGGMGGMGGMGGMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYV6</accession>
    <name>G0RYV6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Replication factor C subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0000720</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690626.1">
        <property type="nucleotide sequence ID" value="XM_006690563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYV6"/>
    <dbReference type="STRING" id="759272.G0RYV6"/>
    <dbReference type="GeneID" id="18254110"/>
    <dbReference type="KEGG" id="cthr:CTHT_0000720"/>
    <dbReference type="eggNOG" id="KOG0990">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042324_2_0_1"/>
    <dbReference type="OMA" id="AEDNLPW"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000028">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000004">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000129">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF9">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="74"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS23384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="388" mass="42572" checksum="528650531EF056B5" modified="2011-10-19" version="1">MSDYEDEMDIDISSKSIIFSANNTAKGKRSVGNLPVEAEDSLPWVEKYRPATLSDVSGHQDILATINKFIESNRLPHLLFYGPPGTGKTSTILALARRIYGAENMRQMVLELNASDDRGIEVVREQIKTFASTKQIFTMGSSAGRAGIAAFKLIILDEADAMTNTAQMALRRIMEKYTANTRFCIIANYSHKLSPALLSRCTRFRFSPLKEQDIRSLVDKVIEEENVKITPDAVESLVKLSRGDMRRALNVLQACHASSTPLQLRDGPKIPGDQIVRDTITTETIYNCVAAPPPDAIKKILNTLLSTSDVTACLTIINMLKISQGLALADIITSLSEELVKLEVKPQVMITWLDALAEIEYRVASGANEAIQTAAVVGAVRNGVELMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYW1</accession>
    <name>G0RYW1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0000770</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690631.1">
        <property type="nucleotide sequence ID" value="XM_006690568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYW1"/>
    <dbReference type="GeneID" id="18254115"/>
    <dbReference type="KEGG" id="cthr:CTHT_0000770"/>
    <dbReference type="HOGENOM" id="CLU_1461147_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="185" mass="21226" checksum="607254E105E16FA5" modified="2011-10-19" version="1">MTGVAYEWYHGRKERLENQNLEDNWQASATPLSDGSQTQSKELVMLLPCGLSKYEGNIATYLTRLHDLNLTVHLTGEMYRRLVYAAMPAEITRKIHHELKRHTNPTDDEFDEAVRTAGEAHEDTLLKFELQRRSGKVGYGSSRERMTPDSRRTRQERASSPFGQSSKLTSRNRGGNTGEWNNQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZ38</accession>
    <name>G0RZ38_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CTHT_0001590</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690708.1">
        <property type="nucleotide sequence ID" value="XM_006690645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZ38"/>
    <dbReference type="STRING" id="759272.G0RZ38"/>
    <dbReference type="MEROPS" id="M41.004"/>
    <dbReference type="GeneID" id="18254197"/>
    <dbReference type="KEGG" id="cthr:CTHT_0001590"/>
    <dbReference type="eggNOG" id="KOG0734">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_9_0_1"/>
    <dbReference type="OMA" id="MSHFEWA"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000175">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FTSH 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048438">
        <property type="entry name" value="Yme1-like_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076:SF97">
        <property type="entry name" value="ATP-DEPENDENT ZINC METALLOPROTEASE YME1L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076">
        <property type="entry name" value="METALLOPROTEASE M41 FTSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21232">
        <property type="entry name" value="Yme1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="390"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="791"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="833"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="846"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGS23466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="865" mass="93158" checksum="C65299BEF7FE1CD9" modified="2011-10-19" version="1">MAFHASGLPSIASATSDLWPSLANTLAIPFRGPKCSSPAPSKHLNSANAPPAAAAPVVAAAGLVEAAVRSHLPDFLRDAPVPTPRFLDRGLANASPVNIFSEISHMSSRSLAMANPLFRRSYAALMSRPLSTLPGCRYMSTYQPSRMQQFSWIQPLSVSRNVQRRSLHHGGIPRDLLAAREAAANRNPNSASAQASFYQLLLKANLPAIVVERYQTGRFATNEATDEAYRQALAMLNASAGSGTGATVDSNAYGSGLSPSTLQAVGQAVAAHRTGGNTAFSAQAPNGTKSGPLHVIVDETTGSALLRWIKFFLWFGLCAYISMVVITMVVEGLSSIKRPGAKLTDIEAKAEHQKARFSDVHGCDEAKEELQELVEFLKNPEKFSALGGKLPKGVLLVGPPGTGKTLLARAVAGEAGVPFFFMSGSEFDEIYVGVGAKRVRELFQAAKAKAPSIVFIDELDAIGGRRNSRDATYVRQTLNQLLTELDGFAQNSGVIILAATNFPESLDKALTRPGRFDRQVVVPLPDVRGRIAILKHHASKIKMGKDVNLEHIAQRTPGLSGAELENIVNQAAIYASKNKANAVTQAHFEWAKDKVIMGAERKSMVITAKEKEMTAYHEAGHALVAYYSKDTSGQLYKVTVLPRGRSLGHTAFLPEMDKYAWSVKDYLGLIDRAMGGKVAEEIVYGHDLVTSGVSADLDQATRTAWNMVARLGMSQRLGPVEYLRNYNSLSSETRAMVEAEVKRVLDESYARARALLLEHRKELDLLAKALVEYETLDRSEVEKVIRGEKLEGRIPVPPGPMSVPKPDESESVKPGLGGIIPIPGKGAGNGSGNPPPAPPPPAPAREGTEESKRIMEEGEDGRIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZB6</accession>
    <name>G0RZB6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alanine--glyoxylate transaminase</fullName>
            <ecNumber evidence="3">2.6.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0002380</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.44" evidence="3"/>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690786.1">
        <property type="nucleotide sequence ID" value="XM_006690723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZB6"/>
    <dbReference type="STRING" id="759272.G0RZB6"/>
    <dbReference type="GeneID" id="18254276"/>
    <dbReference type="KEGG" id="cthr:CTHT_0002380"/>
    <dbReference type="eggNOG" id="KOG2862">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027686_5_1_1"/>
    <dbReference type="OMA" id="YEWDTPA"/>
    <dbReference type="OrthoDB" id="7403325at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008453">
        <property type="term" value="F:alanine-glyoxylate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004760">
        <property type="term" value="F:L-serine-pyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019265">
        <property type="term" value="P:glycine biosynthetic process, by transamination of glyoxylate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000049">
        <property type="entry name" value="Alanine-glyoxylate aminotransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000027">
        <property type="entry name" value="Serine--pyruvate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152:SF24">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152">
        <property type="entry name" value="AMINOTRANSFERASE CLASS V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="10">
        <location>
            <begin position="144"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS23544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="497" mass="54112" checksum="B785BE29F7A8F92D" modified="2011-10-19" version="1">MPRQQDPANERFPITGAGNPHPHPHDRYGYLQYRRYHSDYRYDVPSPSPASSPAPGLRLSLISRHLAPVYPINTPWTVERLPDIIDTTLLPKRQSRTLSTSTSSSNLESPKMPSSQPPHATLLIPGPIEFDDAVLQSMSHYSESHVGPGFVAVFGEALTMLRKLFQTSDPAAQPFILSGSGTLGWDLVAANLIEPGEDVLVLGTGYFSDGFADCLRVYGANVTELKAPVGTRPTLPEIEKALGEKRYKAITITHVDTSTGVLSDIKEVAALVRRVSPETLVVVDGVCSVGCEEIRFDEWDLDAVVTASQKAIGCPAGLSISIFSGRAMKAFQNRKAPVAAYFASMKNWTPIMQNYEAKKPSYFATPSPQLIRALHTALSQILARPLEERFAGHKATSDRIKSRIAELGLKQVAPNPAEQAHGMTAIYMPEGIQPAQILPILAKKGVVFAGGIHKEIASKYIRFGHMGVSALDAERGDVDKALKALEEALEEVGYKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZC8</accession>
    <name>G0RZC8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PITH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0002510</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690798.1">
        <property type="nucleotide sequence ID" value="XM_006690735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZC8"/>
    <dbReference type="GeneID" id="18254289"/>
    <dbReference type="KEGG" id="cthr:CTHT_0002510"/>
    <dbReference type="eggNOG" id="KOG1730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005807_1_0_1"/>
    <dbReference type="OMA" id="RWLIVQK"/>
    <dbReference type="OrthoDB" id="4090074at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001179">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001163">
        <property type="term" value="F:RNA polymerase I transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019350">
        <property type="entry name" value="RNA_pol_I-sp_TIF_RRN6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048535">
        <property type="entry name" value="RRN6_beta-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048536">
        <property type="entry name" value="Rrn6_K-rich"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28221">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28221:SF2">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10214">
        <property type="entry name" value="Rrn6_beta-prop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20639">
        <property type="entry name" value="Rrn6_K-rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PITH" evidence="2">
        <location>
            <begin position="1014"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="986"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1197"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1000"/>
            <end position="1019"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1216" mass="134803" checksum="27265085F4DBA9FB" modified="2011-10-19" version="1">MDDRRHAVPAASRAKARRLRPDGILGRLTYAPIAPGEEIGEMRRNRAHGDVPHFRQVTPFTLWCAPAISSAPQPGDLRPWEMVRSQSNFLLENFPEAAIIDDSVESLLLHEIVASQPHMKRQTPPSHSPSMLAVGEITDLRNPDLPTKGHPVLAAASGIAGNVLCLISLAREECTWTDPDIKVRQYAPHPQIEGVWSQSEVPITLIRFPVDLKKGDPIRWLIVQNGNSTTVYEPELRSIPIATGYGSTVTQVFANPLFTIPSDATGGAMHCDACVMRDPETDVPMLAVIDQLGHWSIFEIKGRRSARPKILTPVSIMRGNCLMGSISKHPAMRIPKDPVPHRVLFMTAEVRNRGGSKAMSKAKSEKSEKSVFEEKHRRPILLLCNPQALSLFNTATGKFYVASHVVLAKDTQRILAVEPSKIDPSQAFILTTTSVLWVAVKDSRKQGLTLEVLVSCAHQKDANDPTLRLDVSPAAYLGGTKACFVCVRSARESEVTVFWFIYPQSGLPARYHRSVIQLRGPPGVVWVHIHPLGRRVGLEEPASETGLALRRAQLRFFQIMTLGHDLDIHSTLCAWSDDAGISVPPPDHKEILDDSGTHRHKLLQTLTSAFVVPDGFDERFVFQQKKELQVPSSPHNNKAVERQSPVDLSFVAERLLSTGSRDEAMYEDHSMAEEVDFSFISEVIQRGSEEGYMPRQSLLDLAVSHLPGDLFQLAREWDIQREAIQRRTGERHFVPEARPPIIHFGPDDLLERLQEMFPESSNSGQSATREKVLQDMAAELYFASIGISAVPEAWTAPPGKLLSSQPFPSSPTLLFSQPSLFSPTKISSSWKGKAKATSDDSLEEQPQGDTVVLRLRKYATINTSDTANGEPELNLSRWDLGVDPDKITWRPGQDLEAEAALERRISKREARRRKAERLSQAILGRDSFGGRLSTSSQILPSSQQPIIIPTSQPSIVSSQRLPPWGDMAAASQPVLGAYGSPIRMRAGSPLRKEYRPPRDSLGSEFGSQSQSQLQSQDTPSQQFSLYQHIDFDQIVTLNESEHGSGKAVVKKTWAERMNPEPEVASDADEELIINVPFTGQVRLHSILLRTSDSESAPKTLKVIINRDDVDFAFASETDGTQTFELARTNEVQELPVRRARFNAVRRIALFFPENFGDGDEDTTRISYIGFKGEWMQLGRAPTNIIYEAAANPGDHKIKGTEVNQMGHSIGGKGPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZJ9</accession>
    <name>G0RZJ9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0003220</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">cis-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAPP small subunits family. TRAPPC4 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690869.1">
        <property type="nucleotide sequence ID" value="XM_006690806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZJ9"/>
    <dbReference type="STRING" id="759272.G0RZJ9"/>
    <dbReference type="GeneID" id="18254360"/>
    <dbReference type="KEGG" id="cthr:CTHT_0003220"/>
    <dbReference type="eggNOG" id="KOG3369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053380_2_1_1"/>
    <dbReference type="OMA" id="NKTFHEG"/>
    <dbReference type="OrthoDB" id="246406at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14856">
        <property type="entry name" value="TRAPPC4_synbindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.70:FF:000007">
        <property type="entry name" value="Putative sybindin-like family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF15">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS23627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="175" mass="19562" checksum="623A952807000068" modified="2011-10-19" version="1">MGHGYEFVVMTVFALIIINKAGGLIYNRTFHEGGLNKVSTNDLLVLAGTFHGVHAITARINPLRHLSNNANAAAGNRSSSSSGSLGLQARPDPPAGLEVLETENFRMQCFCTLTGTKFLLFTDTAQANVDVTMRRVYDMYADYVMKNPFYQLEMPIRCDMFDRKLSSYIREINNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZN5</accession>
    <name>G0RZN5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0003600</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690905.1">
        <property type="nucleotide sequence ID" value="XM_006690842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZN5"/>
    <dbReference type="GeneID" id="18254398"/>
    <dbReference type="KEGG" id="cthr:CTHT_0003600"/>
    <dbReference type="eggNOG" id="ENOG502QZI3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036934_1_1_1"/>
    <dbReference type="OMA" id="TKVRCYG"/>
    <dbReference type="OrthoDB" id="2590011at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.100">
        <property type="entry name" value="YAP1 redox domain. Chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF6">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="4">
        <location>
            <begin position="65"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="244"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="254"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS23663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="382" mass="41966" checksum="A9921FF424277A5E" modified="2011-10-19" version="1">MASASPQNSLPQPSYSTGTSGQDTDPLSVFNLSILKTLAEKRATRDGNPPKRRGPKPGSKPALTRRQELNRQAQRTHRERKEAYIKALEDEVLRLREIFSNIAREKERLVEENRRLKTLLAQVGINYGRPVTEDLMSQQSTSCMSSSSIAGSYGPGSSNSTAFTPPPLSACTGPMEANAEAMTHGPNLVLDYEQIGIDFVLTLEKPCMNHMPWLLERNYETGLNEPCGHALMASCPPEPFSDLTPDIPFGDSYGNRSHSGTGNKSKSNTACSADGGTSQDSTSAVGNHGQRTWELSKADLTTLLDLSKKLDLDGEITPVMAWGMILGHPRFSELREEDFVRLTEELKGKVRCYGFGAVMEEFEVRDALESIFATKMELGVAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZP6</accession>
    <name>G0RZP6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0003710</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690916.1">
        <property type="nucleotide sequence ID" value="XM_006690853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZP6"/>
    <dbReference type="STRING" id="759272.G0RZP6"/>
    <dbReference type="GeneID" id="18254409"/>
    <dbReference type="KEGG" id="cthr:CTHT_0003710"/>
    <dbReference type="eggNOG" id="ENOG502S22Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035244_1_1_1"/>
    <dbReference type="OMA" id="AYPKIAQ"/>
    <dbReference type="OrthoDB" id="10039566at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022185">
        <property type="entry name" value="DUF3712"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046368">
        <property type="entry name" value="Tag1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895:SF1">
        <property type="entry name" value="LIPID-BINDING SERUM GLYCOPROTEIN C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12505">
        <property type="entry name" value="DUF3712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="344" mass="38384" checksum="1A06201B6276A8C3" modified="2011-10-19" version="1">MADVDKGAVAQAENVSEKPQRRGGFLGHCARFWWAYLIFLCVVVVVVVPCVLLVAVPKLAQEKLDEAELTLDKITVTGTQSKRLTMKIDTQIHTDGSVHATVMGFEGVMYLTDYEPQTPFARINFPETTSEKHQVVNVTQEIEIDDVEALTRFNTWLLHNETVRVTVEGDTKVKVRGIPRKYGVTFKKTIEMPGLKMFEGLKVNETSINLNPTDNFWGTAWIPNRSQVAIELGNVTFHDYLLGEEVGEVYLDNLTLQPGMNRHIMRATIEADPVLNAMQSEPYCHPGKGILPFVIRGKKVVNNGQSLDYLANALATGNQTVPIDIGWTLKNSLNITLPCKDDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZQ1</accession>
    <name>G0RZQ1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Globin-sensor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0003760</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690921.1">
        <property type="nucleotide sequence ID" value="XM_006690858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZQ1"/>
    <dbReference type="GeneID" id="18254414"/>
    <dbReference type="KEGG" id="cthr:CTHT_0003760"/>
    <dbReference type="eggNOG" id="ENOG502RZ5I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063074_0_0_1"/>
    <dbReference type="OMA" id="YIHLGAC"/>
    <dbReference type="OrthoDB" id="10027058at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044398">
        <property type="entry name" value="Globin-sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42071:SF1">
        <property type="entry name" value="GLOBIN-SENSOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42071">
        <property type="entry name" value="PROTOGLOBIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11563">
        <property type="entry name" value="Protoglobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Globin-sensor" evidence="2">
        <location>
            <begin position="22"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="292" mass="32367" checksum="FEA4B3DF417A345D" modified="2011-10-19" version="1">MSTARTRPMQHVDRKELYTNLEARIRYLHSFLDFGTNDIEALKSGAKYIQALIPAVVNIVYRKLLQYDITARAFTTRSTAFEGPVDEQPDESSPQILHRKSFLRAYLKKLCSDPTQMEFWEYLDKVGMMHTGIGRAHPLHIEYIHVGATLAVIQDVLTEAILSHPRLHIARKIAIIKALGKVIWIQNDLFAKWYVHDGEEYTEGVDYEAIVEKEGYLHGKKVLSPEEELSLSESSSSDDTATGCPGQRAAAAGSVCPFSGLSTSMAGLKVQENGDKANGENASKADGAVNGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZS4</accession>
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        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">CTHT_0004010</name>
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    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690944.1">
        <property type="nucleotide sequence ID" value="XM_006690881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZS4"/>
    <dbReference type="STRING" id="759272.G0RZS4"/>
    <dbReference type="GeneID" id="18254439"/>
    <dbReference type="KEGG" id="cthr:CTHT_0004010"/>
    <dbReference type="eggNOG" id="KOG0737">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004471_6_3_1"/>
    <dbReference type="OMA" id="SDGNWTW"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="510"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="723" mass="82774" checksum="0A8CD04355948204" modified="2011-10-19" version="1">MPLCWPSGLSARLFKNRENDPTNPEKLPDSGSSTTSASGSTLGPEADTKPQKSKKTKWKGRRTKKKKSDDNKTTEDNSDLKKDGEDAKVELEGNKEGEKRKVAVGSVCEAKNIYKGPADEEGNWTWSDKCPDDVEEAAENEETAKFAIIVRKQKSNDSRKSLEAHSIIIQSPWLRKALSDILNGYHGVVCELSRLEFEAPFKPFVHRWTEFTKYLEKPDLDEKTKEHMQLLYNILDYEIGDKVRAFQDYLRNGVVSFKDLWMIFQPGQIVVSKHIGKLSGFEMLETEYMSDQCGKFLQVRCDSVEYDGKEFGRYMESINIPEFLGTKKITGLKVYPLHFHEKQEGLKAELIKRGEIFEKLAGHHYKQYTGKAITWDREGNEVEVQINGRIVVDIDSFNRFSPFRARYVNEWTPADLENFTKYKAEKGLPDDKFVLPPYYQMIARPRTSGYSLKYKKWVDFFVDQISEIEWNEHAFDRLVLPPDQKELILSFSESQLAGSKFDDVISGKGKGIICLLSGPPGVGKTLTAEAVAENLRVPLHMLTSGELGSDPWVVERELTSILELVARWNAILLLDECDVFLEARSTHELERNKIVSIFLRTLEYYEGIMFMTTNRVEDIDAAFQSRIHVSIEYPDLNSVSRRTIWSNFLKGSSLKSSLTDRDIAELAELKLNGRQIKNVLKTAQLLAARKKSPTLDREFIETVLKIEKKRPGVPQPDKMLHYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0S056</accession>
    <name>G0S056_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0008810</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691408.1">
        <property type="nucleotide sequence ID" value="XM_006691345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S056"/>
    <dbReference type="STRING" id="759272.G0S056"/>
    <dbReference type="GeneID" id="18254919"/>
    <dbReference type="KEGG" id="cthr:CTHT_0008810"/>
    <dbReference type="eggNOG" id="KOG1499">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_933837_0_0_1"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040048">
        <property type="entry name" value="ZNF277"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13267">
        <property type="entry name" value="ZINC FINGER PROTEIN 277"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13267:SF3">
        <property type="entry name" value="ZINC FINGER PROTEIN 277"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="236"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="176"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS23217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="298" mass="33173" checksum="EEC3DE3D8696415B" modified="2011-10-19" version="1">MAEAYPVPSDVDSVSSSDNEECWLEAAGAPRPDKTAEDHKAEEKGKDRLDTGNYSDWSSEEGDDEDDEEQVQIKSFFDDATYSNVKDMVSAMKSQFGFDFLAVRDRLGLDFYGCVRLINFVRRHVRDGGNNTNIPDPITAEHLADDRLLIPVLENDELIFYLDDLPASPKPAKKAATATQADVDELLRKNSELQDQLDRLAQQFNNYRLAVEHTLDKRWGLDGEGNEDEKTSSLFMSAASAPSPGTSTATTVGPAQRTPDTAENGSGSEQDDSAYYFESYAHNGKSYSEQYFRFDLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0S084</accession>
    <name>G0S084_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein s15-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0009120</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="476" last="476">
            <title>High-resolution structures of a thermophilic eukaryotic 80S ribosome reveal atomistic details of translocation.</title>
            <authorList>
                <person name="Kisonaite M."/>
                <person name="Wild K."/>
                <person name="Lapouge K."/>
                <person name="Ruppert T."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="35079002"/>
            <dbReference type="DOI" id="10.1038/s41467-022-27967-9"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.90 ANGSTROMS)</scope>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2023" name="Nat. Struct. Mol. Biol." volume="30" first="670" last="677">
            <title>Structural inventory of cotranslational protein folding by the eukaryotic RAC complex.</title>
            <authorList>
                <person name="Kisonaite M."/>
                <person name="Wild K."/>
                <person name="Lapouge K."/>
                <person name="Gese G.V."/>
                <person name="Kellner N."/>
                <person name="Hurt E."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="37081320"/>
            <dbReference type="DOI" id="10.1038/s41594-023-00973-1"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.20 ANGSTROMS)</scope>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2024" name="Nat. Commun." volume="15" first="716" last="716">
            <title>Methionine aminopeptidase 2 and its autoproteolysis product have different binding sites on the ribosome.</title>
            <authorList>
                <person name="Klein M.A."/>
                <person name="Wild K."/>
                <person name="Kisonaite M."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="38267453"/>
            <dbReference type="DOI" id="10.1038/s41467-024-44862-7"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.10 ANGSTROMS)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691436.1">
        <property type="nucleotide sequence ID" value="XM_006691373.1"/>
    </dbReference>
    <dbReference type="PDB" id="7OLC">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="SP=1-153"/>
    </dbReference>
    <dbReference type="PDB" id="7OLD">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="SP=1-153"/>
    </dbReference>
    <dbReference type="PDB" id="7Z3N">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="SP=1-153"/>
    </dbReference>
    <dbReference type="PDB" id="7Z3O">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.30 A"/>
        <property type="chains" value="SP=1-153"/>
    </dbReference>
    <dbReference type="PDB" id="8OO0">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="SP=1-153"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S084"/>
    <dbReference type="EMDB" id="EMD-12976"/>
    <dbReference type="EMDB" id="EMD-12977"/>
    <dbReference type="EMDB" id="EMD-14479"/>
    <dbReference type="EMDB" id="EMD-14480"/>
    <dbReference type="EMDB" id="EMD-17004"/>
    <dbReference type="STRING" id="759272.G0S084"/>
    <dbReference type="GeneID" id="18254950"/>
    <dbReference type="KEGG" id="cthr:CTHT_0009120"/>
    <dbReference type="eggNOG" id="KOG0898">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097347_2_0_1"/>
    <dbReference type="OMA" id="KTHCRDM"/>
    <dbReference type="OrthoDB" id="10258210at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.860.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="entry name" value="30s Ribosomal Protein S19, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_uS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_uS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_uS19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005713">
        <property type="entry name" value="Ribosomal_uS19_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_uS19_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003121">
        <property type="entry name" value="PRK04038.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01025">
        <property type="entry name" value="uS19_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="RIBOSOMAL PROTEIN S19P FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="Ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7 8 9" id="KW-0002">3D-structure</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS23245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="7OLC"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="7OLD"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="7Z3N"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="7Z3O"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="8OO0"/>
        </source>
    </evidence>
    <sequence length="153" mass="17565" checksum="DC7EEA09CE73CD72" modified="2011-10-19" version="1">MADTEYNAEEAAELKKKRTFRKFSYRGIDLEALLDLDSDELRNVLHARARRKINRGLKRRPLGLIKKLRKAKQEAKPNEKPELVKTHLRDMIVVPEMIGSVIGIYSGKEFNQVEIKPEMVGHYLGEFSITYKPVKHGRPGIGATHSSRFIPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0S098</accession>
    <name>G0S098_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CTHT_0009260</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine from methionine and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AdoMet synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691450.1">
        <property type="nucleotide sequence ID" value="XM_006691387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S098"/>
    <dbReference type="STRING" id="759272.G0S098"/>
    <dbReference type="GeneID" id="18254964"/>
    <dbReference type="KEGG" id="cthr:CTHT_0009260"/>
    <dbReference type="eggNOG" id="KOG1506">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041802_0_1_1"/>
    <dbReference type="OMA" id="ASYMARY"/>
    <dbReference type="OrthoDB" id="5852090at2759"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18079">
        <property type="entry name" value="S-AdoMet_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000001">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000003">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000004">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="S-adenosylmethionine synthetase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-adenosylmethionine synthetase N-terminal" evidence="13">
        <location>
            <begin position="21"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase central" evidence="14">
        <location>
            <begin position="133"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase C-terminal" evidence="15">
        <location>
            <begin position="255"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGS23259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="399" mass="43661" checksum="A8AFC48A46AEE14C" modified="2011-10-19" version="1">MASNGVSNGVSAGKHYNEGTFLFTSESVGEGHPDKICDQVSDAILDACLAEDPLSKVACETATKTGMIMVFGEITTKAKLDYQKIVRQTIKDIGYDDSSKGFDYKTLNLLVAIEEQSPDIAQGLHLDDRLENLGAGDQGIMFGYATDETPELFPLTLLFAHKLNAAMAKARRDGTLPWLRPDTKTQVTIEYKHDNGAVVPLRVDTIVVSAQHSPDITTEELRKEILEKIIKTTIPPQYLDDRTIYHIQPSGLFIIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDFSKVDRSAAYVARWIAKSLVAAGLCRRVLVQLSYAIGVAEPLSIYVDHYGTSQKTSAELVKIIRDNFDLRPGVIVKELDLAKPIYLQTAKNGHFGSNQSFPWEKPKQLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0A3</accession>
    <name>G0S0A3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0009310</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SUN family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691455.1">
        <property type="nucleotide sequence ID" value="XM_006691392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0A3"/>
    <dbReference type="GeneID" id="18254969"/>
    <dbReference type="KEGG" id="cthr:CTHT_0009310"/>
    <dbReference type="eggNOG" id="ENOG502QPVV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033459_1_0_1"/>
    <dbReference type="OMA" id="CSYACQS"/>
    <dbReference type="OrthoDB" id="5339822at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051526">
        <property type="entry name" value="Beta-Glucosidase_SUN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005556">
        <property type="entry name" value="SUN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31316">
        <property type="entry name" value="BETA-GLUCOSIDASE-LIKE PROTEIN NCA3, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31316:SF0">
        <property type="entry name" value="SECRETED BETA-GLUCOSIDASE SIM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03856">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="93"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS23264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="429" mass="45827" checksum="7212607AD915F8E4" modified="2011-10-19" version="1">MKRFVKTAVAAAAVVGVTAQPHHGHRHLHAKKHDHQHLQQRDTVVVTKVVQGPTVTEYWLDGKKIDAEQAEKGIENGDFYVVGSSKPTFTAPPPIVSTSLAGPEHGGQFFEKATSEPTTTSTSTSTSSTSTSSTPTPEPTKEAPKPSGPKGLDADFPSGKVPCSKVPTEYGAIEIPWSGTDGWTTIISVGKLIKGVALDNIYTAVSGGCKPGDLCSYACPPGYQKTQWPEESQGATGQSVGGLYCNEDGFLELTRPKYTKLCEPGAGGVFVRNELSGNAAVCRTDYPGNENMIIPLDTYPGNTYPLTNPDSKTYYRWKGMPTTAQYYVNNEGVEVEEACTWRSSKYPESAGNWAPTNIGVGKSEDGITYISIFPNLPTSNAVLNFDIEIIGDISGTCYLKSGKYYGSSTGCTVGMREGGTATIVFKKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0Q8</accession>
    <name>G0S0Q8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative RNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0010900</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691610.1">
        <property type="nucleotide sequence ID" value="XM_006691547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0Q8"/>
    <dbReference type="STRING" id="759272.G0S0Q8"/>
    <dbReference type="GeneID" id="18255128"/>
    <dbReference type="KEGG" id="cthr:CTHT_0010900"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054059_0_0_1"/>
    <dbReference type="OMA" id="EFPVDRY"/>
    <dbReference type="OrthoDB" id="252020at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061574">
        <property type="term" value="C:ASAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12365">
        <property type="entry name" value="RRM_RNPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034201">
        <property type="entry name" value="RNPS1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15481:SF0">
        <property type="entry name" value="LD23870P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15481">
        <property type="entry name" value="RIBONUCLEIC ACID BINDING PROTEIN S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="160"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="240"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="326"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="366"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS22618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="382" mass="43634" checksum="05CCDC35C6A18E42" modified="2011-10-19" version="1">MSSPGRATDRMALDDDRHSRSRSCSRTRSPRSRSRSRSRTPASQYSRRSRSPTSMDRRRDSRARSPARNGGGGGRYRSRSRSHSRSISRGRTRSRSLSRSPSRSPRSRSRSRSYSRGRDRSYSRGYSRSRSRSRSESPRQRSTKVGWLRYCSGGSRLTGLQIVVERLTKNITEDHLWEIFGQYGEIEDLDLPISRVSGTNRGTAYILYYNEDDAQQAITHMHEAQLDGNIIHVSIVLPRRKVSPPPPLARRGPRGPPANVRAVMPGGGGGRGGGRYASRSDVYRPRSLSRSRSRSPLPPPSGGRRYRSRTRSRSRSRSASYDSRSRSRSRSRSPRRGGGRYGGGSRRNESYDRRRSVSRDSYDRRSRSRSRTRSRSRSYERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0W4</accession>
    <name>G0S0W4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2-deoxy-D-gluconate 3-dehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0011470</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691666.1">
        <property type="nucleotide sequence ID" value="XM_006691603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0W4"/>
    <dbReference type="STRING" id="759272.G0S0W4"/>
    <dbReference type="GeneID" id="18255185"/>
    <dbReference type="KEGG" id="cthr:CTHT_0011470"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="OMA" id="IIRRHDA"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000398">
        <property type="entry name" value="Probable 2-deoxy-D-gluconate 3-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF5">
        <property type="entry name" value="2-DEHYDRO-3-DEOXY-D-GLUCONATE 5-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="16"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS22674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="259" mass="28107" checksum="907DD73A05248B90" modified="2011-10-19" version="1">MTTNNSIMSLFSLEGQTALVTGGTRGIGKAVAIALAEAGADVLLVQRDESSTETRDAIRALGRKAEIYTADLSNPRDVSKIVPRVLADGHEIRILINCAGIQRRHPCEQFPESDFNEVIQVNLNSVFTLCRDVGAHMLQLEPHPVTGRRGSIINFASLLTFQGGWTVPAYAASKGAVGQLTKSFANEWTARGITVNAIAPGYIETDMNTALLNNPERLASISARIPAGRWGTPDDFKAECSAYREFRSQAAKISSELWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1D4</accession>
    <name>G0S1D4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial</fullName>
            <shortName evidence="5">Glu-AdT subunit A</shortName>
            <ecNumber evidence="5">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0013200</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="5"/>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691836.1">
        <property type="nucleotide sequence ID" value="XM_006691773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1D4"/>
    <dbReference type="STRING" id="759272.G0S1D4"/>
    <dbReference type="GeneID" id="18255358"/>
    <dbReference type="KEGG" id="cthr:CTHT_0013200"/>
    <dbReference type="eggNOG" id="KOG1211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_7_6_1"/>
    <dbReference type="OMA" id="QPASYCG"/>
    <dbReference type="OrthoDB" id="421993at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF7">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="6">
        <location>
            <begin position="29"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS22844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="500" mass="53526" checksum="C0BCC4615597298C" modified="2011-10-19" version="1">MLARSRPSSLPWLPKDAIPSPHSPTRFTLAVKDNIATADGHTTTTCGSPFLSNYRSPFEATIVSQLRARGGRVVGKTNLDEFGMGSHSVHSAFGAVAQDSPEQLAGDVKALRSAGGSSGGSAVSVLLGEADVALGTDTGGSVRLPAAYCGVVGFKPSYGMLSRFGVVPYANSLDTVGFLAREVRPIRELIVGDGTTQGLWAEHDPNDPTSLTPSARKRCARSRQFYSPSQSPDPSILNGLRLGLPLEYNIHELSPTIRDAWSRAASLLQSHFSARIIPVSLPSTRHALSAYYVIAPAEASSNLAKYDGIRYGVRDTSVENDAAADGVLYASSRGKGFGPEVRRRILLGAYTLSSKAMDNYFLQAQRVRRLVRRDFDRVFALPNPLVDPDQQVFDLSDLPEGTIMEDKWGPEEVDFLLCPTAPTLAPTLGEVMEGGSPVDEYVNDVFTVPASLAGLPAASVPMPVEGEGEGKTAGLQLIGQYWDDARLLAVAEVIREILRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1G3</accession>
    <name>G0S1G3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0013500</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691865.1">
        <property type="nucleotide sequence ID" value="XM_006691802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1G3"/>
    <dbReference type="STRING" id="759272.G0S1G3"/>
    <dbReference type="GeneID" id="18255388"/>
    <dbReference type="KEGG" id="cthr:CTHT_0013500"/>
    <dbReference type="eggNOG" id="KOG3385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086133_1_0_1"/>
    <dbReference type="OMA" id="MNRMLIM"/>
    <dbReference type="OrthoDB" id="261831at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15853">
        <property type="entry name" value="SNARE_Bet1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039899">
        <property type="entry name" value="BET1_SNARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="24"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS22873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="21244" checksum="26A772618E4A1944" modified="2011-10-19" version="1">MASRFGPSTLHQRDPRSDLFRGYTGSSSTINRTMSASPASGYRHSQSSPYSSNQNGTTGGSSGYGGYGAGVGGGYSHGAAQGNPYLGVGGETGGRGFRAATPNKKGQYSDAVLNELESQNEQQVEGIMGKMTIAIGDEIRESSALAEKMNEGFDQTRLRLRGTMNRMLLMAERTGVGWKAWLGFFVAVIILFIYVWLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1K2</accession>
    <name>G0S1K2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0013900</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
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        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
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    </dbReference>
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        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347">
        <property type="entry name" value="RING/FYVE/PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RING_FYVE_PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="RINGv"/>
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    </dbReference>
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        </location>
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        <location>
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            <end position="392"/>
        </location>
    </feature>
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        <location>
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    </feature>
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            <begin position="30"/>
            <end position="45"/>
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    </feature>
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            <begin position="72"/>
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        </location>
    </feature>
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            <end position="366"/>
        </location>
    </feature>
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        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="392" mass="44257" checksum="0E8E80E7F99F69D7" modified="2011-10-19" version="1">MASRPYGPDQPYQSSWTWPTNTPSEYSSGNVVSNANIASPASSSSQTPTHGYSTALPSSTQHSGTSAYPASQPQDQQQQQQQQQQQQQQQRRRHYGPRTCRICLETVYPTTELDDSFASKVFQTKARVRYVSEDPSLGRLISPCLCKGSQKYVHEGCLQQWRKTSPLSERNYWRCPTCQFEYRLERLTWGRWLSNKWTRMALTAGIMLFAMFVLGFMADPIINFGLDPIGCIIRFFFGIMASIIRLFTFGYWPARSVEPEPEPEPATWGWHFIKGFLSLGLLGFLTSVLPTSAGFHLIDIRIPGGARRRGRDRLDYVNWFLVFLGIASFLTGTWKLVNFVSSMVLENASIKVVDIQGSDEPDEDDVTAPTTPTSPTATSRSSFVYSESKKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1L1</accession>
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    <organism evidence="4">
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        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
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                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
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                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR058348">
        <property type="entry name" value="DUF8035"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42081">
        <property type="entry name" value="ZINC FINGER PROTEIN DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42081:SF1">
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <end position="837"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
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        </location>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1N5</accession>
    <name>G0S1N5_CHATD</name>
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        <submittedName>
            <fullName evidence="12">Zinc finger domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="12" type="ORF">CTHT_0014240</name>
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    <organism evidence="13">
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            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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    <dbReference type="GeneID" id="18255462"/>
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    <dbReference type="OrthoDB" id="6077919at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
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    </dbReference>
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        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF57">
        <property type="entry name" value="ZINC FINGER PROTEIN 154-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
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    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="292"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="314"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="120"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS22945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="344" mass="37249" checksum="A76B3F6DF417BB27" modified="2011-10-19" version="1">MASSTVTTHFAHSPPQNVHYGYVSPPSPPMDDTTSKCSLPSISNLLGLADQGSPTSETSLQSQQQQQQQQQQQQQQQQQQQQQQSQTSKPETRPVSTGYGGVTAPALPVPKTAFPPSPPLTSDSSFDNFNPPSARPLSQVSNGSSYYFETTPPLQLDHPESRQMPSSATAPPSRVSVQSSAYQPHYTGPTYLGQPAMTSYYPPPQPPVSALYYQRPLPQNFPPPLSMPMTLAPTAAAGAANPWQHHHYLAPSSTASYPQSQDRYICPTCNKAFSRPSSLRIHSHSHTGEKPFKCPFPGCGKAFSVRSNMKRHERGCHNYDSGSTHSRSSSVGSSLSTSLGIGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1P7</accession>
    <name>G0S1P7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0014360</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691949.1">
        <property type="nucleotide sequence ID" value="XM_006691886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1P7"/>
    <dbReference type="GeneID" id="18255474"/>
    <dbReference type="KEGG" id="cthr:CTHT_0014360"/>
    <dbReference type="eggNOG" id="ENOG502QTQ8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044876_1_1_1"/>
    <dbReference type="OMA" id="YEWSLAC"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF7">
        <property type="entry name" value="CIPA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="4">
        <location>
            <begin position="16"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS22957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="340" mass="37593" checksum="0C05ADB69D6C50E5" modified="2011-10-19" version="1">MKSETPGHVEKVAIVGATGNIGSSFTQALLNTGKHTVTALVRPESKGKVPEGVKVVRSDFNNESSLVEALKGQEVLIITLSTMAPLEVHDRLVVAAKKAGVRYVVPNLYGYPIDRSNSQNGESNGNSYDQVFLDRYPYIQKFLDKVTEIESDGLRWFVLATGFWYEWSLALGEQCFGFNIKDRRVTFFDDGKRTITTTTWAQCGRAMAALLSLPQQGPSASPSLVDFLGTQVRVGSFRVSQRDMLDSLNRVLGTTDADWEIKYESSKKRVKDGIEALEKGNKVGFAKALYSSVFDPSYKQGDYGAVEPLANDALRLPKEDLDEATRKVVAMIESGWNPWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>G0S273</accession>
    <name>G0S273_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA cytidine acetyltransferase</fullName>
            <ecNumber evidence="9">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">18S rRNA cytosine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NAT10</name>
        <name evidence="15" type="ORF">CTHT_0016220</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2016" name="Cell" volume="166" first="380" last="393">
            <title>Architecture of the 90S Pre-ribosome: A Structural View on the Birth of the Eukaryotic Ribosome.</title>
            <authorList>
                <person name="Kornprobst M."/>
                <person name="Turk M."/>
                <person name="Kellner N."/>
                <person name="Cheng J."/>
                <person name="Flemming D."/>
                <person name="Kos-Braun I."/>
                <person name="Kos M."/>
                <person name="Thoms M."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="27419870"/>
            <dbReference type="DOI" id="10.1016/j.cell.2016.06.014"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (7.30 ANGSTROMS)</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="journal article" date="2017" name="Nat. Struct. Mol. Biol." volume="24" first="954" last="964">
            <title>3.2-A-resolution structure of the 90S preribosome before A1 pre-rRNA cleavage.</title>
            <authorList>
                <person name="Cheng J."/>
                <person name="Kellner N."/>
                <person name="Berninghausen O."/>
                <person name="Hurt E."/>
                <person name="Beckmann R."/>
            </authorList>
            <dbReference type="PubMed" id="28967883"/>
            <dbReference type="DOI" id="10.1038/nsmb.3476"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.20 ANGSTROMS)</scope>
    </reference>
    <reference evidence="19 20 21" key="4">
        <citation type="journal article" date="2019" name="Mol. Cell" volume="75" first="1256" last="1269.e7">
            <title>Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration.</title>
            <authorList>
                <person name="Cheng J."/>
                <person name="Bassler J."/>
                <person name="Fischer P."/>
                <person name="Lau B."/>
                <person name="Kellner N."/>
                <person name="Kunze R."/>
                <person name="Griesel S."/>
                <person name="Kallas M."/>
                <person name="Berninghausen O."/>
                <person name="Strauss D."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="31378463"/>
            <dbReference type="DOI" id="10.1016/j.molcel.2019.06.032"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.50 ANGSTROMS)</scope>
    </reference>
    <reference evidence="22 23 24" key="5">
        <citation type="journal article" date="2024" name="bioRxiv" volume="0" first="0" last="0">
            <title>Molecular Basis for RNA Cytidine Acetylation by NAT10.</title>
            <authorList>
                <person name="Zhou M."/>
                <person name="Gamage S.T."/>
                <person name="Tran K.A."/>
                <person name="Bartee D."/>
                <person name="Wei X."/>
                <person name="Yin B."/>
                <person name="Berger S."/>
                <person name="Meier J.L."/>
                <person name="Marmorstein R."/>
            </authorList>
            <dbReference type="DOI" id="10.1101/2024.03.27.587050"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.02 ANGSTROMS) IN COMPLEX WITH ADP AND MG(2+)</scope>
    </reference>
    <comment type="function">
        <text evidence="9">RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in 18S rRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51424"/>
            <dbReference type="Rhea" id="RHEA-COMP:13575"/>
            <dbReference type="Rhea" id="RHEA-COMP:13576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a cytidine in tRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in tRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53876"/>
            <dbReference type="Rhea" id="RHEA-COMP:13670"/>
            <dbReference type="Rhea" id="RHEA-COMP:13671"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with TAN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="9"/>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692125.1">
        <property type="nucleotide sequence ID" value="XM_006692062.1"/>
    </dbReference>
    <dbReference type="PDB" id="5JPQ">
        <property type="method" value="EM"/>
        <property type="resolution" value="7.30 A"/>
        <property type="chains" value="i/j=1-1073"/>
    </dbReference>
    <dbReference type="PDB" id="5OQL">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="i/j=1-1073"/>
    </dbReference>
    <dbReference type="PDB" id="6RXT">
        <property type="method" value="EM"/>
        <property type="resolution" value="7.00 A"/>
        <property type="chains" value="CR/CS=1-1073"/>
    </dbReference>
    <dbReference type="PDB" id="6RXU">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.50 A"/>
        <property type="chains" value="CR/CS=1-1073"/>
    </dbReference>
    <dbReference type="PDB" id="6RXV">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.00 A"/>
        <property type="chains" value="CR/CS=1-1073"/>
    </dbReference>
    <dbReference type="PDB" id="6RXX">
        <property type="method" value="EM"/>
        <property type="resolution" value="7.10 A"/>
        <property type="chains" value="CR/CS=1-1073"/>
    </dbReference>
    <dbReference type="PDB" id="6RXY">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.70 A"/>
        <property type="chains" value="CR/CS=1-1073"/>
    </dbReference>
    <dbReference type="PDB" id="6RXZ">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.40 A"/>
        <property type="chains" value="CR/CS=1-1073"/>
    </dbReference>
    <dbReference type="PDB" id="9AYM">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.29 A"/>
        <property type="chains" value="A/B=1-1073"/>
    </dbReference>
    <dbReference type="PDB" id="9B0E">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.19 A"/>
        <property type="chains" value="A/B=1-1073"/>
    </dbReference>
    <dbReference type="PDB" id="9B0I">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.02 A"/>
        <property type="chains" value="A/B=1-1073"/>
    </dbReference>
    <dbReference type="PDBsum" id="5JPQ"/>
    <dbReference type="PDBsum" id="5OQL"/>
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    <sequence length="1073" mass="119633" checksum="68380697C1D37605" modified="2011-10-19" version="1">MTVQKTVDSRIPTLIRNGLQTKKRSFFVVVGDHAKEAIVHLYYIMSSMDVRQNKSVLWAYKKELLGFTSHRKKREAKIKKEIKRGIREPNQADPFELFISLNDIRYCYYKETDKILGNTYGMCILQDFEAITPNILARTIETVEGGGLVVLLLKGMTSLKQLYTMTMDVHARYRTEAHDDVIARFNERFLLSLGSCESCLVIDDELNVLPISGGKGVKPLPPPDEDEELSPAAKELKKIKDELEDTQPIGSLIKLARTVDQAKALLTFVDAIAEKTLRNTVTLTAARGRGKSAAMGVAIAAAVAYGYSNIFITSPSPENLKTLFEFVFKGFDALDYKDHADYTIIQSTNPEFNKAIVRVNIHRNHRQTIQYIRPQDAHVLGQAELVVIDEAAAIPLPLVKKLMGPYLVFMASTISGYEGTGRSLSLKLIKQLREQSRAGANPNGGNAVEVDRSTLKATKETTSVGGRSLKEITLSEPIRYAQGDNVEKWLNTLLCLDATLPRSKISTTGCPDPSQCELLHVNRDTLFSFHPVSEKFLQQMVALYVASHYKNSPNDLQLMSDAPAHELFVLTGPIQEGRLPEPLCVIQVSLEGKISKQSILKSLSRGQQPAGDLIPWLVSQQFQDDEFASLSGARIVRIATNPDYMSMGYGSKALQLLVDYYEGKFADLSEDAAAEVPRSIPRVTDAELSKGSLFDDIKVRDMHELPPLFSKLSERRPEKLDYVGVSYGLTQQLHKFWKRAQFVPVYLRQTANDLTGEHTCVMIRPLQDGNDPSWLGAFAADFHKRFLSLLSYKFREFPSILALTIEESANAGAMLDPSNAPTELTKAELDQLFTPFDHKRLESYANGLLDYHVVLDLMPTIAQLYFTGRLREAVKLSGLQQAILLALGLQRKDIDTLATELNLPGSQVLAIFMKIMRKVTQHFGALVSGAIAAELPDPNKTVGVSKENAMGIHDDEVVGLKFEALEQRLEDELDEGGDEALRELRKKQRELIDSLPLDQYEIDGDDDAWKEAEKRVASAAKSGKKVDGTLVSVPSAKAAKRKAEEMAALRDELEKMEKGKERGSKKAKKEKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0S277</accession>
    <name>G0S277_CHATD</name>
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            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 3</fullName>
        </alternativeName>
    </protein>
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        <name evidence="12" type="ORF">CTHT_0016260</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006692066.1"/>
    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:cis-Golgi network"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:Golgi transport complex"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:autophagy"/>
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        <property type="entry name" value="COG3_C"/>
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        <property type="entry name" value="COG3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007265">
        <property type="entry name" value="COG_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302:SF8">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20671">
        <property type="entry name" value="COG3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04136">
        <property type="entry name" value="COG3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 N-terminal" evidence="10">
        <location>
            <begin position="150"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 C-terminal" evidence="11">
        <location>
            <begin position="296"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS22110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="792" mass="87125" checksum="21DD677744FF70C5" modified="2011-10-19" version="1">MYEDSLYSFVPEFQHRRAPSTTTQPSSGHQRKASLLQPPTTEAAEAEAPQPLAALLEAQEDDANVPPEPSVPRRAKSYSDFHDIVRVQATVHVRKRKQKTRRRRGSGRGWEALAVPESVEAQLPQAEEPEEEEGVEEELLKASQGEYLLYHEELALAERHLTTLINDTDNALRLLESLCTSFATVDEQTGSFRAQCDGLVTEQKRLQALAEDVGRDLQYYTYLDSATRRLNAPGAGRLMLILQSTYRDAESYLARYQSLLTKALHLLEVGFKNHLNKVSAEVGKQIAATQSESARHALAYGRFEELVLESYNLIPNLQHVVRSAYNEAGHPTGLPTADIYANTVNNLFHAYWNVRERDLKPIIQHDLDTFRAEAKESLAAAAHAFIKQAFERAFSEACLFGRIFSIEPAHSTDAKSAFAALKGHQRSIPTGTNIAPIATTLQSALQNAPLETVCDVVGWILHEYLLSDFDPSEEEEETPLAVRSREWAFRLLAEHLWTFTDSLFDAEITKSIIKAPLTPDSLKMGPTTGNDVSSNAFPTVKHALELLVLFDQSMPKERSARNSPVVFRIITETISSLQRAEARIRSVKPHSPTDPDLFMIKNLLLLKNELVTLEIGDIRAAPHQTAVAALADRGVQHFAQIWDTLRRNAPQGGLLGGIWNGIGRVGSTLAPLSGYIPGSSLFGAGQGQAAGAGGQAGAGVAGVGGGSGVQDAHERLDGLLRQHIGAFTKRWAGTLHDARSGRLGGKNLGKVEKELEEMLERAFSGQPEIVAKLREAIAIEMEGIGRERVRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2A1</accession>
    <name>G0S2A1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription initiation factor TFIID subunit 12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0016500</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF12 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692153.1">
        <property type="nucleotide sequence ID" value="XM_006692090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2A1"/>
    <dbReference type="STRING" id="759272.G0S2A1"/>
    <dbReference type="GeneID" id="18255688"/>
    <dbReference type="KEGG" id="cthr:CTHT_0016500"/>
    <dbReference type="eggNOG" id="KOG1142">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014055_0_0_1"/>
    <dbReference type="OMA" id="INMAIPK"/>
    <dbReference type="OrthoDB" id="2193432at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07981">
        <property type="entry name" value="HFD_TAF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000037">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037794">
        <property type="entry name" value="TAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003228">
        <property type="entry name" value="TFIID_TAF12_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264:SF21">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03847">
        <property type="entry name" value="TFIID_20kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 12" evidence="8">
        <location>
            <begin position="656"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="184"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="438"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="539"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="101"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="184"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="438"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="451"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="501"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="547"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="582"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS22134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="770" mass="83016" checksum="FB6756AAB4F9CEAE" modified="2011-10-19" version="1">MNQTPAQGQGQGQPGQGMANRPPNAPSAANVAAPGGAPRQQGTPMYRPEMMRNIPLLSDEEKTKYERGLQQLWLMHDNTAPGSAENIEAKKKIAEFGRVLLTKLQQRRQQQQLQQQRQQQQQQQQQQQQQQQQQQQVQQQMQQQAQQPQTQPQQGQPQQQLQQAQVQQQVQQQQQIPQQQQQAPQQQQQQQQPQQLGQPGQQVQMMPQNQQPQVAQNVQPVAPTTVPQQQPAPATQTAPNQMGAPNSAAAQLRSLPAHIVSHVKDVTFLAPNNVVDKAGWIDQLKLQYAQKLFVMDSAGRQIKQIAASLADQSLPPEERKKLEEKKQTLEKQYNDAISFANTVRKQYMQKPAQNGAAVQNAANVARPQSAQGASAMTQPGAGVGNGTPVAAPVNPMQSSAAAINTAIETAKKQQMAAGRMAGAVNAMAAQVQSPATPVQAQVSPATQVHATQQSVPQQPQQIQQAQPTQQPQAQVKIEPGTAPHPAPLNTTMAGPTGVPSAAAPAQNAARMQTPTSATPTSANPNIRPLTHAAAMNLASQQRPGMPAVPTAASGAAPGTPMGIMGAAQQQQQQQPGHSHAHPPQPTQAPPPHSTNPKLPIPKVLHDKAIQMPQPVPNIGGAGSGRPTYTSGVMNQPALPKTPAFQLEGEGERVLNKKKLDELVRQVCGGTAEGQDGNMLTPEVEESVLNMADAFVDNVLHQACRNAKERGSKVLEIRDIQLVLERVYNIRIPGYASEELRTVRKVQPNSNWIKKMSAVQAAKVVPGKGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2023-02-22" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2F0</accession>
    <name>G0S2F0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0017000</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692202.1">
        <property type="nucleotide sequence ID" value="XM_006692139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2F0"/>
    <dbReference type="GeneID" id="18255738"/>
    <dbReference type="KEGG" id="cthr:CTHT_0017000"/>
    <dbReference type="HOGENOM" id="CLU_993975_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="144"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="280" mass="30952" checksum="E617500A302DAEDE" modified="2011-10-19" version="1">MSSFAECESLSSPAPPTDCQDLKHRAFTVGIAAYTFWQRTLMHQHIPTAFTTGRKILALLGDFVTLYLGKVSSELEALSLQICASQTEITLDDITKLLFLIQAWASIHDWLDCVATELDNHAVGDAEQKISNLCEQLIDRDRQMKEKNATIADLTDQLAAQDNKVYQLTSELDDSFAKIDALREALEEALAADKAACAQADVVVAQMDALRQQKAVAVEELARVQAEAAALAAENAALREREQAQVLELEAKYKEIAALRQQLGILQKQANEHLQTEVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2L9</accession>
    <name>G0S2L9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0017710</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692271.1">
        <property type="nucleotide sequence ID" value="XM_006692208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2L9"/>
    <dbReference type="STRING" id="759272.G0S2L9"/>
    <dbReference type="GeneID" id="18255809"/>
    <dbReference type="KEGG" id="cthr:CTHT_0017710"/>
    <dbReference type="eggNOG" id="ENOG502SHQM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010001_1_0_1"/>
    <dbReference type="OMA" id="QAACLVC"/>
    <dbReference type="OrthoDB" id="3429912at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="57"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="176"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="251"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="740"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="203"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="745"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS22252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="851" mass="93284" checksum="AD02E9DA66DC6B20" modified="2011-10-19" version="1">MDRPDSTVPSAPTTAPPPQPAQQPVQPDGRAAQIADTVVVRAPGDPPRDQNSRRAAACLVCRRSKIKCEKGRGGSDDRCHRCLQLGVQCIRPDFHVGRRKGVKKSGFFSKRTGLEKALHQVEQALRRCGPGVEATKIVSDLKAIIASGQGNQGGSLPSLNGPLGNGVHVSTRLKASENHHGPISSDHTRGASRQSDHDILLPDVSSDTGDSSSSEQDVISLPQESTPSQGHVPEESLAVDDAENPLQLLARASDLHVSPKPGMDLTMRESMSRQRSRQSKQEEKISEVAKFFKLTQFSLDIGPDLDPVNLGLITMEEAETLFNFFHTNLAHTRWGLDPVLYTAAWTRSRSAFLFTSIAAAASLFLPHARALSRRLSNHCKTLVNRIMVDRYRSVEIVLAFMVNVPWMFPGKHSTDDETCWYVSMATTMALDLSLHKILVPVSSLRDGAAGRGGVGAIARADCIDPKVALAMDGFADVEPGSEYGLRLLRRRERCWIALFVLERGMCLARGRCYTVPITPILKGCDQWHLSNIADTMDGHLVSMAVLRRDLDDLFASIRSLCDESRDGRTDGAVVARQIQMMVEKFFDEWHAKWGVSIGTGPQHRLPPYVQILVTHTRLSIYSSVINHPTAPTEVRHFFHAAGLSSALNVMRAAIQGEGQLSSMPNNTAIMISFAACFALRLSGQFTGNSNLAPSVRTLIEETAEVLERIGSFTEHRNGMSTLYGKYLKYIVKKVAAATSSSAEPPVRPSAGPNPEPLSHHHTPTTPYSRHSHARPPFGMTDPLPPNPPVSGFLEPPLWTEPVQFSSMSDDQIVEALSRVNTEFDPALSMYPWDDAAALDWLNWSNLPNFGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2P7</accession>
    <name>G0S2P7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Monooxygenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0018010</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692299.1">
        <property type="nucleotide sequence ID" value="XM_006692236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2P7"/>
    <dbReference type="STRING" id="759272.G0S2P7"/>
    <dbReference type="GeneID" id="18255839"/>
    <dbReference type="KEGG" id="cthr:CTHT_0018010"/>
    <dbReference type="eggNOG" id="ENOG502RX5T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_478164_0_0_1"/>
    <dbReference type="OMA" id="WINICEI"/>
    <dbReference type="OrthoDB" id="4589334at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="278"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="570" mass="64510" checksum="71D3E5F1B378AD5C" modified="2011-10-19" version="1">MEEYRDRTADLSIRVAKQFRQPICSCKTSGKRAPKKKPGRKTTSSGVSKKKPDRTRASRKAQQPNNPNSADNHPPFNTKLRPPWLWPIPDTRSPSDQLCEVCAALDLFEYLAGYRTIEEDPPKLKLGNVSDLVQKPWCPLCRLILTGLRLHRGDAMLEDPNASVEYVRERSLLVSVEGEEYPHKVYFGIKPLVTDILDKPLAKITPDCIQPLRPEGIDFGLVRLWLEYCEKHHGPECQTSELLKALKLSHPTQVLGNNFRCIDVEIGCVVSPPPNARYVALSYVWGPYKVLKAEKSNIYVLKMPGAFFNKPEIRDHLPKTIRDAMVVTKEIGLRYLWVDSFCILQGDEEETPMQLRSMNLIYAGAYLVIIAAGGDNANAGIAGVQPGSRGISCQQLIEQIRPGFRIGIDYNWEMELKESKYRTRGWTFQEERLANRMLVFIGGTVAFQCRIESESRSEYLAWSPTREFVRREESIPPDWLDIAPRADEDIELYMERELSLVHDIYNAFAGVAQLMKHYLCSDFCHGLPTIFFTYFLCWTVLDGEHFGPGPAGSGAASLIPAGSARTQMII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2S8</accession>
    <name>G0S2S8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nitrate reductase [NADPH]</fullName>
            <ecNumber evidence="6">1.7.1.3</ecNumber>
            <ecNumber evidence="5">1.8.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CTHT_0018340</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>nitrite + NADP(+) + H2O = nitrate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19061"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Energy metabolism; sulfur metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.7.1.3" evidence="6"/>
    <dbReference type="EC" id="1.8.3.1" evidence="5"/>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692330.1">
        <property type="nucleotide sequence ID" value="XM_006692267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2S8"/>
    <dbReference type="STRING" id="759272.G0S2S8"/>
    <dbReference type="GeneID" id="18255872"/>
    <dbReference type="KEGG" id="cthr:CTHT_0018340"/>
    <dbReference type="eggNOG" id="KOG0535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4576">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_5_1_1"/>
    <dbReference type="OMA" id="EESTSQW"/>
    <dbReference type="OrthoDB" id="10051395at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050464">
        <property type="term" value="F:nitrate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000007">
        <property type="entry name" value="Sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.420.10:FF:000002">
        <property type="entry name" value="sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF7">
        <property type="entry name" value="SULFITE OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0349">Heme</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="16">
        <location>
            <begin position="102"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00015499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGS22311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="682" mass="74842" checksum="CB6E3CF937175246" modified="2011-10-19" version="1">MATRVRTASGTLKSALHHTHPRPTLRAFGRSSVRPTSSSSSTSKPRQPTKVARSAPIGLLVGGSVLASAIAITQLTGSDDSHHHIEEQSQNAPIKDDRDPSLPRYRLSTIRQHDAHSPEPWVTSSDKVYNITSWVSAHPGGDIILRAAGKSIDPYWEIFSIHKQPHVREILDQYLIGYIDVADLGPDGRPKMEEVEDPFEGDPKRDERLVTLTAKPRNAETPTGEVAREFITERGVFYVRNHMWVPQVDERTADDTHVLTVELPDGEERRYTLRELKTKFPSHRVTAVLQCSGNRRSDMTRQVGHTNGLQWGVGAISNAEWEGVRLADVLADAGLKVASYPSLTQTSPPPSDPQIPDPNTLHIHFHGLEAYSASIPLPKALSPSEDVLLAYGMNGGPLPRDHGFPLRAIVPGTVAARSVKWLSKIRVADEEATSQWQRRDYKCFGPNEGANPDWERAVAIQEMPVTSAVTGVWVGSDVKRVPWMGEKRLLATEEKGEGKKNEGEVALQGYAYSGGGRAIARVDISLDGGNTWDQAELVDDCAGGKCKGSKAWAWTRWRYCGTLPSPPTTRTISSASPSSSAPIQALEDGAEAQNGTEKKIGEKDACTELIVKATDTSYNSQPETHAGIYNVRGNLATAWHRLRVCPKCLQNSTCNSNKNIWSDGAVVYGCGFSREDEKKEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2Y2</accession>
    <name>G0S2Y2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tetracycline:hydrogen antiporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0018910</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692384.1">
        <property type="nucleotide sequence ID" value="XM_006692321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2Y2"/>
    <dbReference type="GeneID" id="18255929"/>
    <dbReference type="KEGG" id="cthr:CTHT_0018910"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_3_1"/>
    <dbReference type="OMA" id="IMFPFCA"/>
    <dbReference type="OrthoDB" id="2351791at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000018">
        <property type="entry name" value="Putative MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF94">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="502"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="38"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="545"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="607"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="693"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="617"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="693"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="737"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS22365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="784" mass="83461" checksum="88A7202B37B969FB" modified="2011-10-19" version="1">MGRDGDLIEIRPDQLERGERPLAAAENEWKPGSKEYAVMVTLSVISLMVALDATILVSVLPTLAIDLGGTATDAFWAGTSYLLSCAVCQPFIAALSDIFGRKEMLLLSVFFFTIGTILCAPVAKDFTVFFVGRSIQGIGGGGIITMGQVIFADIVPLRQRPKYFSMVLAAWALGSVLGPLIGGLFVEHVIWAWCFYINLPFCAVGLVLVPIYVKLKTQKTSIISKLRRVDWLGGFLFIGGMTSFLIGLSWAGIQFEWKSAETIAPMVVGIVGVVASLFWECYGAVEPFLRPSLFNSRSTLATYAIALFQGFILFCALYYIPFYFTAIKFHRPTRSGLDIFPVTCFLLPGSIIISLMTTRLGRYRWAIWSGGVVTAIACGLLVLFRQHTKTAVWAVILAVFGIGNGMLLTSVNIGIQAASRVEDAGRAAAMYAFMRTLGMSIGVAVGGTVFQNVMSNKLNELGLPTQISKDSEAFVAKMYEMAPEDPVRIGAQKAYLSGFHGVYWTITGAAVASFLISLLIKQYSMDKLLATKFVLKGASRPVMVSSAAGPDEPSDRVDNAANNTTSCEEITPAEETKLVPTETVTSAFSPLPTPAGTNLTVSDAIMPAPVSGSIHPSAPSSSTTSQPSSAPATSQQHGLSGESEQAAIVYLVRPGGAILPVKVVQQRRQPAPSYDDAVAATSAAAAAAAAAGASGNSEGSSSSAAAAGRGAKTTQPKGQAEVQAEAEGQGQGQSEGQKTKKEGGESEGEESKVFHIISEAYFEDEEGHAQTVVMDYYPVWMMPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G0S358</accession>
    <name>G0S358_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0019760</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692460.1">
        <property type="nucleotide sequence ID" value="XM_006692397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S358"/>
    <dbReference type="GeneID" id="18256014"/>
    <dbReference type="KEGG" id="cthr:CTHT_0019760"/>
    <dbReference type="eggNOG" id="ENOG502SEVN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_251409_0_0_1"/>
    <dbReference type="OMA" id="PTCIEAE"/>
    <dbReference type="OrthoDB" id="4207369at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="761"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="963"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1045"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="517"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="613"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="850"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1054"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1096"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1187"/>
            <end position="1200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1224" mass="128679" checksum="3BAAE2944457AE8E" modified="2011-10-19" version="1">MFDFASPGPEAAREPSPTPTSTATFQPSWERVAVAPVPGMRRQPKIWKRVAGLVNAPLPRNYVVAMTELASNGQGPRKRMRHEGHIPVWGEPKWHPKIDEPRDGKNELTKARDAVMRAVHDKALAAMTAPLPARRRTTYAEEKLKWVPRKRHHSRWPIEPKKQDRMVAHLQPYIEFKVPSTSAPPIETPSKLDAKQMARRCTRRLSRSPSKQLAAVRLSPVKKSALFMSPVKKSLGCLSPTKVVDSPHRTFRVNATPTKVNLNSIKITPPRKFPLKPSTPTQQREDKAVTSSAKPSVATPATTQPSPSTPLLPLLFDSPVVDSQPEPIYETHRRTSLHAAKRLDRISSGAARLLALKSRKSPNRRHSFTTLSNVQAATPKPTKERRNSFSSFRADHNEVGTLTTDNLRSANATLKNAQRVVEIDMKTDLDIFGKPSAAPKDGAATQGPVQTRAETTPAPAVTPSAGVDSPLSSLAALFAAGSRNPPDTPDVPSRSATPSGNPSPASTETPSRSSCLPATPKAAANAQSPAAEAAEVIGATNTSPDVDATSSGLSTSDSPKPVPKETTPTKDLNDNDELLAHFPSAIQTCFDATSPSPMASDKVGDASSETLITAASKDATSTPTSSPPPASSPEQATTEHSSPRKPSQLTAELDAESSPKFTPINGHTSSPTNITSGSSQEKDLPEFEEPTHEQQVDEDTVMKDAPIEELSAASNDNADQLRVTATEPLKPQDGSTESDMDMLRDFITRVTAEKTAALAANAAAKSERRGHIFGATPSKVESDTSPSRTPLGEKSPNSPTTGNKKRKLDEFNNDVASKEAAPSEPQPTGRRLKRRRSLDAVPTSIDGESPDQNNSSDQASAGLRRSTRARTTRVDLTRSAPSANIALSQIPRARVSRAGASPTTPAKPSRPTPQDRKKELELEALTRVNTRNNKGAAIPPPLMLLMLNADLEVRKKVGIDDVMEPKKGSEAQVPAKQTDKPKKSVRFAENLVSYREPSPTVITGAERQAAASLETVIPDGDEIAEAEPTVGAAVAKTQPVLAKKKVVAGKRKASPASTAAATAPSAGPAGPAVAPASSATAKRSTRSSRLPPPKPVAKSVVPGEAPAAAAAAAAGSAGKKRSASTSSPAPGRAAAPSARSPAAKPGAKPTAVVRGARTAPAGAPRASAKSAAAGSAPTGRTTRSTSAGLAAKRAAAAAAASGEEMEGVGKPAPKRKGTAAAGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0S382</accession>
    <name>G0S382_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0020030</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692484.1">
        <property type="nucleotide sequence ID" value="XM_006692421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S382"/>
    <dbReference type="STRING" id="759272.G0S382"/>
    <dbReference type="GeneID" id="18256041"/>
    <dbReference type="KEGG" id="cthr:CTHT_0020030"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_11_1"/>
    <dbReference type="OMA" id="WMPLDTW"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902181">
        <property type="term" value="P:verruculogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000063">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF237">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ATNE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS22465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="531" mass="60189" checksum="D99943C8D40E2068" modified="2011-10-19" version="1">MHFNTDHLQLWLGLGVVAGLLYICGLVIYRLFFHPLAKYPGPFLAKLTDAYMLYYAWRGDRHLEFWRLHEKYGKFVRFAPNGLSINSNQALKDIYGFRSNVRKSEFYDAFVHPAPNTHNTRDKELHARKRRVLSHAFSDSAIKEVERYILANIRTFCDAIGDYGRNLAERKGWSTPKNMSDWCNWLAMDILGDLCFGKAFHMLDRPDNRYAIDLVGVAAQRHLLCGTMPIVNKLNLDRILFRNIAAGRARYMAYSRSQLAERTALGDETDRRDFFYYLLTARDPETGQGFTTPELWAESNLLIIAGSDTTSTAMAATLFYLTRHPDALKLVTQEIRSKFTNLEDIHQSPQLTSCTYLRACIDEAMRLSPSVGGILPREVLPGGITIDGQRVPAGVVVGVPHYTIHHNAAYYPDPFSYRPERWISGQLPDGTQSPFTQNQVALAQSAFCPFSIGPRGCIGKGLAYVEMTNTLARVLWLYDVRRAPGVEDPGEGGKPGAVYGRHRKDEFQLVDIFTSLKDGPLVEFRKRSDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3B1</accession>
    <name>G0S3B1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cellulase</fullName>
            <ecNumber evidence="3">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0020380</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3"/>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692513.1">
        <property type="nucleotide sequence ID" value="XM_006692450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3B1"/>
    <dbReference type="SMR" id="G0S3B1"/>
    <dbReference type="STRING" id="759272.G0S3B1"/>
    <dbReference type="GeneID" id="18256076"/>
    <dbReference type="KEGG" id="cthr:CTHT_0020380"/>
    <dbReference type="eggNOG" id="ENOG502QXN4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029718_0_2_1"/>
    <dbReference type="OMA" id="YAMIVPH"/>
    <dbReference type="OrthoDB" id="5823761at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142:SF1">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="7">
        <location>
            <begin position="43"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS22494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="251" mass="27510" checksum="6A1CBC2B2C4FD8D7" modified="2011-10-19" version="1">MKFLNFRLGAEAAVSALAAPAGDALTTFRTQKRAPKFQFVGINEDGAEFGKDTLPGQLGRYYIWPSKYSIDTLIGRGMNIFRIPFMIYRLVPNRLNGPIDSTYAQGLIDIVNHITSKGAYAVLDPHNFGVVDDRSQLFADNDKVIFNTNNEYHDMDNQLVLPLNQAAIDGIRAAGATLQLIFVEGNSWTGAWTWVSTGNGATPLNPNDPAAPDGSKIIYEMHQYLDTDVSGTSDNCVSSTIGEQRLREATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3B7</accession>
    <name>G0S3B7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0020440</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692519.1">
        <property type="nucleotide sequence ID" value="XM_006692456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3B7"/>
    <dbReference type="GeneID" id="18256082"/>
    <dbReference type="KEGG" id="cthr:CTHT_0020440"/>
    <dbReference type="eggNOG" id="ENOG502QSKG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_2_4_1"/>
    <dbReference type="OMA" id="YLHIAYG"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="35181" checksum="251FE6BCA87144D4" modified="2011-10-19" version="1">MEPPLGATPSPRAVSPTVDNGPASDAAPETTREPTPESDPELAHDPTPGPASPRPASSEPASPGLSSADEDAGMWAIEFADRFPNAQVVGTDISPIQPTWVPPNISFEMEDCTQPWTYDEESFDFVHIRYLFGSIPNWTELFRQAYRVLKPGGWIETFEADAMLTSEDGPVKEGTPLDQWGKTFREAGDRIGRSFCVINDDLQRKGLEEAGFIKLCQWDFNCPLTGWPKDEKLKLMGEYMHASMEQDMEGVVLYTFKEIMGWTTEEIKAYTAELRQQLRDKSIHPVFKLRCIYAQKPLNPSNSSPSFPSSSAGNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>G0S400</accession>
    <name>G0S400_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Palmitoyltransferase</fullName>
            <ecNumber evidence="13">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CTHT_0022030</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Palmitoyltransferase specific for casein kinase 1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 18 13">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="13"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692672.1">
        <property type="nucleotide sequence ID" value="XM_006692609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S400"/>
    <dbReference type="STRING" id="759272.G0S400"/>
    <dbReference type="GeneID" id="18256241"/>
    <dbReference type="KEGG" id="cthr:CTHT_0022030"/>
    <dbReference type="eggNOG" id="KOG0509">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012510_1_0_1"/>
    <dbReference type="OMA" id="FWVGFRY"/>
    <dbReference type="OrthoDB" id="6781668at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0564">Palmitate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="13 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="487"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="535"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="78"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="112"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="145"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="178"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="211"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="15">
        <location>
            <begin position="438"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="596"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="598"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="618"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGS20376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="742" mass="82927" checksum="B9DA4FC37CBE94E8" modified="2011-10-19" version="1">MPQQHDSPGSPRANGAPTQPPSKSDTATPKLNNEVELGNLPNDPPQNDIMHMARVGDIAGMEKLFATGDYDATYHDDEGITPLHWAAINNQYAMCKFLIERGAPVNKKGGESKATPLQWAAQRCHYYTVHLLLQHGADPLITDGQGYNTLHISTFNGNLLLIILLLHQGIPVDVVDAYGHTSLMWAAYKGYPACVDVFLRWGASVHHTDEQGFTALHWALVKGNAGCIQKLIEYGADRFAKTSTGKTPAITARELNTVAAWHKALFECGYDEDGNPMVPSWPGASYLLKDRRAFTTKFFFLWPFVLVWMVLVIFAGMPVYAGIPIGLIAAYTIIWVGQQMLAYAPPDMRQFEKTPWMTGIFAGSFTLVGLNWFFTLLPTTSSGEDGTWLWNFVFATLFGSTAFFYVRSMVDDPGFVPKLNGIAEQKAVIDELISQWKYDEANFCVHCMIRTPLRSKHCRRCQRCVAKHDHHCPWVYNCIGVNNHRHFFIYLISLTLGVLCFDYLVYIYFSSVIPNASEDCNLLSPFLCRIVNADAYTLLLAIWASIQLTWVSMLLFVQFIQVSRAMTTYENMYGIGGHRSPTYFSSAFTSTGIPLDPSQQASSSSESEAGPSALTGPHGHRHGHRHGHRHGHRHGGFLKHWSRLLGIDTFIETATGRSAAGSLRAKNKRRKNPYNRGCVQNCKDFWCDPAPIFGRRENGAAVLGGEPVNYTEIYEAPVVTEVLRGRTRERGGYERVPVQEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4D4</accession>
    <name>G0S4D4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydrolase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0039780</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS22092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694388.1">
        <property type="nucleotide sequence ID" value="XM_006694325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4D4"/>
    <dbReference type="GeneID" id="18258016"/>
    <dbReference type="KEGG" id="cthr:CTHT_0039780"/>
    <dbReference type="eggNOG" id="KOG4840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049633_3_0_1"/>
    <dbReference type="OMA" id="ALQPTEW"/>
    <dbReference type="OrthoDB" id="10034502at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013744">
        <property type="entry name" value="SidJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591:SF1">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08538">
        <property type="entry name" value="DUF1749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="351" mass="38967" checksum="5FBBC6F65FFBCD2C" modified="2011-10-19" version="1">MGSKFWPKRGSPGILHHWTETLVTFEFTNGAKPKPHSILFIGGLGDGLATTSYVADVVTALQPTSWSLFTLNLSSSYQAWGFGHLDRDTDEIAQCINYIKEYKKEKYGQEGKFVLMGHSTGSQCVLHYLSKPNPHTSKPPFDRWLEHVKRPVVDGGIMQAPVSDREAIQWVISEGFMGKTPMELQETYDKLVAMAKEAVAKDISWDVPLPLSLTSQFGYGFSTPVSARRFLSLVSPESPKSPSEDDLFSSDLPDEHLAKTFGMVGQRGLLRYKLMVLMSGADQAVPSWVDKDKLMARWKAAANANSKTPVWDERSGQIPGASHALSNDDQAEPRRILCSKVLSYIADVEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4E1</accession>
    <name>G0S4E1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0022490</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692715.1">
        <property type="nucleotide sequence ID" value="XM_006692652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4E1"/>
    <dbReference type="STRING" id="759272.G0S4E1"/>
    <dbReference type="GeneID" id="18256287"/>
    <dbReference type="KEGG" id="cthr:CTHT_0022490"/>
    <dbReference type="eggNOG" id="KOG2022">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005271_0_0_1"/>
    <dbReference type="OMA" id="CLASIGK"/>
    <dbReference type="OrthoDB" id="2016913at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF33">
        <property type="entry name" value="IMPORTIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363">
        <property type="entry name" value="TRANSPORTIN 3 AND IMPORTIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS20419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1018" mass="113212" checksum="8D71EBCCE9E27DF3" modified="2011-10-19" version="1">MADSAMEQLPLPTSLAEVESLIRALYQPNPPETITKIQEVLQRLQRSPEGWQLAQSLISHREDNIRFYAALTLIVKINRDSAGLSEEDTSSLLQNIISWTIQSLADGAAPFVTKKLCTALVTFFIHFSHLWPHCVRHFLYCLDLGRGTPVEGLDDALTTEILVSKLDRKKLSAAVWFITSLVEEVGKTDMSAPKFIQVHERLIKTGPDVTCLLARAFNPPEDNPAIKTQGEALACFQAWILYAQRASPNVELVTPLRQLVGPAMNCLADPDLFQPAAELFSDVLSNYSSFFTEEHYNTLASLFESPWAAEHYQRLLHGNHHEDGISFGLLMLAYGDAKVQDLMHGTDARSQGFLEKLTGLLAADGYLVADDTVFVPALEFWSTFIETMVDNIYSDEEDTESWKPLAERHLKAVILNSWRKIQWPPAEVFAEWDSTERTAFNDARKDVSDMLQSVFTLEGSSLVSFFADLFLRVLPTQNWAELEAAAFCLGALADCISEDARNDHVLSNVFSSPFFQLLGQAHGPIPLRLRQTGLALIEKYCEYFERNAQYLPDALNLLFGALGDPVLGGPCARSISTLCSSCRSILTGEAGAFINHYKTIRGSQVLDSLAEERIVQSIASIVQAIKEEGHRLDMFEELYNFLKKDFELAIQLQAQPNILNLSHPDFLRGLETPHPPAVPSAEEIALHIALRSLRCLASMAKGMQDVKEHPIDLDSEPAPHDPNSRLSRLQADIMRVLAGVQSAFGASGEAVEIICNIFRAGFSETEPGPFVFHPDVVTDYFVQQRYETPRIGTLLSTVCSYVGSLYRGPKALVPPQLTRLLPWVISIIQGMPDPDSDTEIAVNGINFVEKVISKYPEILFNAQPSQLIEFFFLFTLKVLDGTEPLPKNAAAEFWANFISLKPSNPALEQAIASAMTHLGPLVARSLMRNIGGHAARSELDRLCEPLKKLVVLRPEAQAWLEQALLEGQACWPGCERVALEDGRAFLRKVIALRGARTTNQVVREFWLACRGSNFAYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4H0</accession>
    <name>G0S4H0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0022790</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692744.1">
        <property type="nucleotide sequence ID" value="XM_006692681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4H0"/>
    <dbReference type="GeneID" id="18256317"/>
    <dbReference type="KEGG" id="cthr:CTHT_0022790"/>
    <dbReference type="HOGENOM" id="CLU_750051_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="369" mass="37961" checksum="EA68CB2F6609F718" modified="2011-10-19" version="1">MGYDKVPTEVDEARTPCLDASGMLDNLNYGACDQCGCTADPTHILVPINMEPMVITSKSRDNGWGLLCKYVIVHTALWLFGLLMFFFGIYVILYMSVIPGASAEMIPAENDVGPIIERDLIVGSSGFFMETPLCTLVATTSTLPTPSDASTVVTAADAETATVSEGPIITPIFTDETTCSPVTITVTVTTAFSADAVYNSALVSSTSAVDAISAQAATEALTSLTMDFVTTVTTTSTSTRVITVTNYTATTYVTVTSVPVNATTSSIIFATAHSPSTFGTDTAYYGTGGTAASATGYIGPTIGNGTFTYSIPPTAAASSADAVSASHSIVATSDGGKGLAGTNTVSEVVKQIKAGYCAVMLAIVTLVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4H6</accession>
    <name>G0S4H6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mitogen-activated protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0022860</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="2"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692750.1">
        <property type="nucleotide sequence ID" value="XM_006692687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4H6"/>
    <dbReference type="STRING" id="759272.G0S4H6"/>
    <dbReference type="GeneID" id="18256324"/>
    <dbReference type="KEGG" id="cthr:CTHT_0022860"/>
    <dbReference type="eggNOG" id="KOG0198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003051_0_1_1"/>
    <dbReference type="OMA" id="FIGAHPF"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09534">
        <property type="entry name" value="SAM_Ste11_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000334">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000214">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000387">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029458">
        <property type="entry name" value="Ras-bd_By2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF56">
        <property type="entry name" value="MAPKK KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14847">
        <property type="entry name" value="Ras_bdg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01304">
        <property type="entry name" value="Ras_bdg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM" evidence="12">
        <location>
            <begin position="57"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="13">
        <location>
            <begin position="250"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="627"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="142"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="391"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="175"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="391"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="656"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS20454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="902" mass="100063" checksum="3C8B24B2BA9F5137" modified="2011-10-19" version="1">MAMLASKSYPAGLGPQSSNMMAAPRRAATTPLPSSQNHAAMLEAEFGDLEPETVKKWDEDDVCHFLRRLKWGQYEDVFRKNNINGENLLELDKTLLQEMGVEKVGDRVRLWLTIKKLRTMVYANQARRQREDLYADVDAQYVPSSYSPQPSGRSVPPTPPSKGYSRQYDLPAGEGSKPSGSISPLSSGDFRSQQQQRYAQSSGYASSQPTPSSTRYPVSPPEQPLSGGRLMHTRNQSSMDGSLMAALPPGQDVIRVISTGGVTKVVKIAGCNTCEEVMRVTLRKFALREDHERNYCFWVLNGTEPDPNQCRRLGDTELWRIIKDHSRPERNRLILRRVPAGEPGQAELERAAAIALEEQAQQQQNHNRVIENMPKQSLLKAQKVLGESWEKMQQPNLSSVPYQDRYERPPPPPPQPQPRRRGELRQFGGLRPPSELIASDLTSYFPDHSKEFIDRTARMSMRRSQRLSRMNHRLSVASTLSFASSIQDAPPIPTIADSWLTASNQIAKPRPRADAASRFREYRDSVASSMLDTLQEEDAQSTTSSINRKSYVSFADSGSDTNTTAALSVTDPDGNVVRHSFFDGAGSTGSGGSSLQDVNQALEEDGEDIDEDLQSFLAGDSWDDSKWIKGALIGRGSFGSVYLALHAVTGELLAVKQVETLGSGTNGQNDQRKKNMIEALKREITLLRDLRHPNIVQYLGCGTSAEYLNIFLEYVPGGSVQTMLESYGALPEPLIRTFVRQILNGLSYLHNKDIIHRDIKGANILVDNKGTIKISDFGISKKLEASNILNGPNNNKHRPSLQGSVFWMAPEVVKQTSYTRKADIWSLGCLIIEMMTGTHPFPDCTQLQAIFKIGGAKATPTVPETASPEAKAFLAQTFEIDHTKRPSADELMLSPFLTPMVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0S537</accession>
    <name>G0S537_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0023960</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692858.1">
        <property type="nucleotide sequence ID" value="XM_006692795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S537"/>
    <dbReference type="STRING" id="759272.G0S537"/>
    <dbReference type="GeneID" id="18256434"/>
    <dbReference type="KEGG" id="cthr:CTHT_0023960"/>
    <dbReference type="eggNOG" id="KOG2704">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011340_5_0_1"/>
    <dbReference type="OMA" id="WHGTRPG"/>
    <dbReference type="OrthoDB" id="286734at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030258">
        <property type="term" value="P:lipid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF4">
        <property type="entry name" value="LYSOPHOSPHOLIPID ACYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="494"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS20562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="567" mass="64447" checksum="4030B3F3B08F9492" modified="2011-10-19" version="1">MIPFIHKPFVYLSGVIGAGPDELKLIFSMLLSYPLTALLKRIPDSRPDLKNLFSVSVSIFYLVGLFDLWDGLRTLLISAVGAYAIAKFLRRSPYMPWIAFVFLMGHMSVSHIARQRANNPRSVDVTGAQMVMVMKLSAFAWNVADGVLPEEYLSDFQKDRRLTELPSLLDYAGFVFFFPSLLVGPAFDFAEYRRWLDTSMFDVPANIDPSKRPRTRKKRRIPRSGTPAVLKLLTALVWIFSFLKLSAYFPPQHLLSDKYMTYGFLRRLLVLHLVGFTARTKYYGVWTLSEGACILAGLGYNGVDPVTGKVSWNRLQNINPWGVETAQNTRAYLDNWNINTSKWLRNYVYLRVTPRGKKPGFRASLATFTTSAFWHGFYPGYYMAFVLASFIQTVAKNLRRHFRPFFLHPTTQQPLPSKRYYDLASWLTTQLTFSFAAAPFMLLGFNDSLIAWKRVYFYAIVGTFSLLAMFMTPGVKKSLRKALEKRQRAFAIPAGEKKEEEEKKKEKKGGEDMVRSPSSSDENGGPVGLGVSDDIERDLDEAVGELKAEVESAVRQRRTGATTLRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0S542</accession>
    <name>G0S542_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">5-aminolevulinate synthase, mitochondrial</fullName>
            <ecNumber evidence="5">2.3.1.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">5-aminolevulinic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Delta-ALA synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Delta-aminolevulinate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CTHT_0024010</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="2.3.1.37"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.37" evidence="5"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692863.1">
        <property type="nucleotide sequence ID" value="XM_006692800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S542"/>
    <dbReference type="STRING" id="759272.G0S542"/>
    <dbReference type="GeneID" id="18256439"/>
    <dbReference type="KEGG" id="cthr:CTHT_0024010"/>
    <dbReference type="eggNOG" id="KOG1360">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015846_6_0_1"/>
    <dbReference type="OMA" id="ARRCPIM"/>
    <dbReference type="OrthoDB" id="10263824at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003870">
        <property type="term" value="F:5-aminolevulinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000006">
        <property type="entry name" value="5-aminolevulinate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010961">
        <property type="entry name" value="4pyrrol_synth_NH2levulA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01821">
        <property type="entry name" value="5aminolev_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF102">
        <property type="entry name" value="2-AMINO-3-KETOBUTYRATE COENZYME A LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="16">
        <location>
            <begin position="205"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="83"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="126"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGS20567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="655" mass="70515" checksum="FB14938EC0028931" modified="2011-10-19" version="1">MDSVLRQSKAMCPFMKKATAAGLRAMSTAVAPAAQAGALSPCGGTMSKLQVLARRCPVMGKAMAIQSARIYGSVAAKAGMATLSPSHSTSGARHANHSGKSGKAKLHTSRSQDAQAVEGTLFREQVPIPPRSPTKQQPATASTNTATATRVNPPVTHPTTKFDYEAFYTAELDKKHKDKSYRYFNNINRLAKEFPRAHMATKDQKVTVWCANDYLGMGRNPEVLKAMHETLDEYGAGAGGTRNISGHNKHAVELEATIARLHHKEAALVFSSCYVANDATLATLGSKLPDCVILSDALNHASMIQGIRHSGARKIIFKHNDVEDLEQKLASLPLHIPKIIAFESVYSMCGSIGPIEKICDLAEKYGAITFLDEVHAVGMYGPHGAGVAEHLDFEAHLQGRHSGTIMDRVDIITATLGKAYGCVGGYIAGSAKLVDTIRSLAPGFIFTTSLPPAVMAGARTAIEYQMRSPTERRLQQLHTRAVKEALTQRDIPVIPNPSHIVPILVGNAELAKLASDKLLHEYGIYVQSINYPTVPVGQERLRVTPTPGHTKEFRDELVRAIDNIWTELGIKRTSDWAAEGGFIGVGEPGVVEPQPLWTDEQLGIADATRDILREIMAESAAAPVAEPTNGLAVPGVTERLLEREARGLMAASVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0S586</accession>
    <name>G0S586_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0032630</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693701.1">
        <property type="nucleotide sequence ID" value="XM_006693638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S586"/>
    <dbReference type="STRING" id="759272.G0S586"/>
    <dbReference type="GeneID" id="18257301"/>
    <dbReference type="KEGG" id="cthr:CTHT_0032630"/>
    <dbReference type="eggNOG" id="KOG0873">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047036_5_0_1"/>
    <dbReference type="OMA" id="IVHEFIY"/>
    <dbReference type="OrthoDB" id="1658724at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="5">
        <location>
            <begin position="173"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS21405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="333" mass="38427" checksum="AD1246D26044B795" modified="2011-10-19" version="1">MATSTVQAMGIAFPNATIAGLGPSPAFTTVLEEVGKANVHLNILERMWAAWYLWMQNDTIATGIMSFVMHELVYFGRSLPWIIIDAIPFFNRWKIQKVSSVCNTPSRVETLANSKQTKIPTWKEQFDCAMLVLLGHCTVELPQIWLFHPIATYFGLEYGVPFPSIWKMAYQIFIFFVIEDAWHYWFHRALHYGPLYKSIHKLHHTYSAPFGLAAEYASPIEVMLLGFGVVGSPIVWVSLTGDLHLFTMYMWIVLRLFQAIDAHSGYDFPWSLRHFIPFWAGADHHDLHHEKFIGNYASSFRWWDYFLDTEAGEAAAKKRREKKLAQLKAKKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5E5</accession>
    <name>G0S5E5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dephospho-CoA kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0024520</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692914.1">
        <property type="nucleotide sequence ID" value="XM_006692851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5E5"/>
    <dbReference type="STRING" id="759272.G0S5E5"/>
    <dbReference type="GeneID" id="18256490"/>
    <dbReference type="KEGG" id="cthr:CTHT_0024520"/>
    <dbReference type="eggNOG" id="KOG3220">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057180_0_1_1"/>
    <dbReference type="OMA" id="RWEMYRA"/>
    <dbReference type="OrthoDB" id="247245at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02022">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001227">
        <property type="entry name" value="Dephospho-CoA kinase CAB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00152">
        <property type="entry name" value="dephospho-CoA kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS20618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="276" mass="30881" checksum="0438F066764A3B88" modified="2011-10-19" version="1">MLIIGLTGSIATGKSTVSRILSQPPYSLPIIDADLLARKVVEPGTPGYRAILKHFLPTTPDLLVPVGPDMPEDGPDGKGRPINRPVLGRRVFGDGEEETKNRKVLNGIVHPAVRWEMFKAVMKAYFQGYQAVVLDVPLLFESRLDRFCGSVVVVAVSDPETQLARLRARDPHLTEEDARRRVISQGDVREKATRAETRGKGRGAVVWNDGDREDLKREVDKVVKELLGEGVTRGYSPRWWAWLLWGCPPLAAAVAAWEYNKNQKANKDWERERAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5Y7</accession>
    <name>G0S5Y7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">4-nitrophenylphosphatase</fullName>
            <shortName evidence="5">PNPPase</shortName>
            <ecNumber evidence="3 5">3.1.3.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0025390</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 5">
            <text>4-nitrophenyl phosphate + H2O = 4-nitrophenol + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21664"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57917"/>
            <dbReference type="ChEBI" id="CHEBI:61146"/>
            <dbReference type="EC" id="3.1.3.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Divalent metal ions. Mg(2+) is the most effective.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.41" evidence="3 5"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692999.1">
        <property type="nucleotide sequence ID" value="XM_006692936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5Y7"/>
    <dbReference type="STRING" id="759272.G0S5Y7"/>
    <dbReference type="GeneID" id="18256577"/>
    <dbReference type="KEGG" id="cthr:CTHT_0025390"/>
    <dbReference type="eggNOG" id="KOG2882">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043473_0_0_1"/>
    <dbReference type="OMA" id="AGLDFHI"/>
    <dbReference type="OrthoDB" id="413953at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000039">
        <property type="entry name" value="Phosphoglycolate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF46">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000915">
        <property type="entry name" value="PGP-type_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00050247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00066659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00069197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS20703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="277" mass="30438" checksum="7908C88D025E9643" modified="2011-10-19" version="1">MSEPKYLTGDIAAINEFIDRFDVCKKIVFVTNNSTKSRDQYLQKFTKLGIPSNTEEIFGSAYSSAIYISRILKLQPPKNKVFVIGEAGIENELRSEGIPFIGGTDPAFRRDFTPEDWQGIADGSHLDPDVAAVLVGLDFHINYLKLAHAHQYLRRGALFLATNVDSTFPMNHNFFPGAGSMSAPLAFMIGQQPLALGKPSQAMLDAVEGKFQLDRARTCMVGDRLNTDIKFGIEGRLGGTLAVLTGVNKKEDWEKADAVAVPAYYADKLSDLLAAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6G9</accession>
    <name>G0S6G9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphogluconate dehydrogenase (Decarboxylating)-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0034880</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693920.1">
        <property type="nucleotide sequence ID" value="XM_006693857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6G9"/>
    <dbReference type="STRING" id="759272.G0S6G9"/>
    <dbReference type="GeneID" id="18257526"/>
    <dbReference type="KEGG" id="cthr:CTHT_0034880"/>
    <dbReference type="eggNOG" id="KOG0409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035117_1_2_1"/>
    <dbReference type="OMA" id="QMFMQAS"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43060">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43060:SF17">
        <property type="entry name" value="L-THREONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="1">
        <location>
            <begin position="7"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="2">
        <location>
            <begin position="176"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="2">
        <location>
            <begin position="317"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS21624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="444" mass="47048" checksum="E817C33F555AB4BC" modified="2011-10-19" version="1">MAEAKPSIAFIGLGAMGFGMALNLVKRGYPVTGYDIWPPALERFRAAGGHTANSPSQTVANKPFCICMVATAEQAQSVLLSGPDPAVPAMPYGAVLILSSTVSCDYVRSLDRQLHSLGRGDIFLIDSPVSGGAARAAEGTLSIMAGMSEEALDKVRPLLAEMADPKKLYVVQGGVGAGSNMKMVHQVLAACQILAASEVMGFAERLGLDLVTTQKAVLQSDTWNWMFEHRTPRMLTHFQPVASAVNIITKDTSIITAEGRRRGFLTPMTSVAEQVYFCAIGRGFGPDDDSSLIRLYTESKGAATVNLSETEEEKLGLVMDLMTGILICSVGEALAFASAVDLDLEQVFDLCVNAAGASTILGKLGPSFIAALRAGVNTNSLVAKDSEGTIGAVVERLQRVLETAQQLKVPLFLGSQAFHILQRALRVTSPRAALCAVVSAWVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6I2</accession>
    <name>G0S6I2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0026310</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693089.1">
        <property type="nucleotide sequence ID" value="XM_006693026.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S6I2"/>
    <dbReference type="GeneID" id="18256669"/>
    <dbReference type="KEGG" id="cthr:CTHT_0026310"/>
    <dbReference type="eggNOG" id="ENOG502QU87">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001720_0_0_1"/>
    <dbReference type="OMA" id="TKVEWLW"/>
    <dbReference type="OrthoDB" id="10070851at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd07609">
        <property type="entry name" value="BAR_SIP3_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13280">
        <property type="entry name" value="PH_SIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039463">
        <property type="entry name" value="Sip3/Lam1_BAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042067">
        <property type="entry name" value="Sip3_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14248">
        <property type="entry name" value="CYCLIN Y, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="371"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="7">
        <location>
            <begin position="1018"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="926"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="977"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1381"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1461"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1514"/>
            <end position="1543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="11"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="345"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="926"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="940"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1390"/>
            <end position="1401"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1484"/>
            <end position="1500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS20793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1543" mass="168367" checksum="B7696F28BFA1D425" modified="2011-10-19" version="1">MNEPTLPPPAALASSRPTPTATGTTPTTTATPSLLPSSLPHPSSPQKQKPSPSSHGPGQTNPVIPVSLTEACLDSPSFRASAIHFADQLDALERWLDSYTRSTSKLVHDVLTLEDGITTYLAKIAPPPAIAAAPDPPVLDADYTLLGLRRAADAARDWWMGILGSIRRFEPVVVDPIRSFLQGPDMRAFRDARKALDVTQRAFDGVLARYMAQSKTKEPSALREDAFAVYEARRAYLKASLDYCMLAPQVRAGLDRVLVRVSADLEREMRRAGEEVFGNVARISELERIRGWSKEMEIAEGGFRRELQMARRDLGESTLAAWKPSRELEDYSVSTVPYLGSRGPQGMQQQQQQQKQNAKHKGNGNGNGAAILEKQGWLFLRVMAGKPVRTTWIRRWYYCRDGVFGWLAQGPNGVLMGDEIGVLLCSARPAVQEERRFCFEIKTKTQTILLQAETQAQLVEWLEVFETAKNRYIEASMKRHQKSVTLPVGMPDPAFSVTPPSIPDFSAKILEGLDEGATSVVSGEGKTLSVPGQEAAAGARQSFDVPRRALTTALARDEGDSGRDHATRIMQKLDLHRTKTVGPSATDATVSGTTALGSGGGLLLPGNTTATSTTTLAHGQQPPLLNPHHNARPKILLAPTTLVKPPILTSLSKTAVLASANAGGAAATTAAAARSLPSAAIANYWGSNSYSSVYCSIPTPSPGPHTPRPDNVADPFSAAATAADKSSAASGSSMHRKTFSADAATVSDISRAAREKASAVSVFPENYPSELRAQYAQFRLLFPAAPAGDMPVLVFNAVWTSTPAEEVQDVGGKRLGLAGNGRIFVTPDRMYFYGHHLGLVVPYILGLDAIAEITAARGRDCDTICLHLSQSGQDTAMLSRITIKVFLDDVASLQARLNLLVDDLQAAEPMELAEIVAALATIDARARDDGDDEDGKRSPSVESWEEVSSNPPLDDASPTGRLGMTATASLRRVQELHGVSSSGKHGRRLSVQAQQQSVKKTHKLHLPTHPVVYEPEDMDKPVAERHFEVSAKSCFHVLFGDRSALFPKLYFERGARNIAQGPWKLQDHGVMRREFRFTVDGTGDMLGRRRASDVIDFQTIDVFRDHMTYVVSHVKIPWHLPHYQSLRLVVKVVITHLAKSKCKLAIYVRPEWLPPSGRQLAPVAFARNLVQRQALDDAVNDAEELADLVTEHVRRLGPHTRRTRRAIQVYGEVGQVSDAINYSPPPPAEDDEKKTGAGGVVVQAVRPRTMADMLLDSGRSFLESVISSVMMWAFAAVRRVFGVLSAHRVILVLLAISAAHNLVIMSQAGSTWWVERRAARYMRRLGVGPNLVMGRAVYLKDLEEAARGSVVEELGDDGGVCYQTFRQTLFLNTTPAELNAPYVPPPPSSSPSSPWSAATSSAARRIHRMRQRLGGYRHDLLVALRVVNGVEREMVRAEWEAWLRGEAWRCERAKGLLFSSEPDLPATPVDGEALGLGLGLNTESEGKDEEKGEEKKKRERMEALKKCCEGVVSQAASRRHSHNLTSSRSFHGLHVELQSPAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0S756</accession>
    <name>G0S756_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ADP-ribosylation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0027500</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
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    <dbReference type="STRING" id="759272.G0S756"/>
    <dbReference type="GeneID" id="18256788"/>
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    <dbReference type="eggNOG" id="KOG0076">
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    <dbReference type="HOGENOM" id="CLU_040729_7_3_1"/>
    <dbReference type="OMA" id="HGFYKYM"/>
    <dbReference type="OrthoDB" id="414781at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001317">
        <property type="entry name" value="Putative ADP-ribosylation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="143"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS20911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="212" mass="23805" checksum="65F0DD6009E9AC41" modified="2011-10-19" version="1">MYHLAKGLYRLATSKEEYSVLLLGLDNAGKTTFHEQVKSIYLPDNPPPKLKTVPTVGQNVSTITLPDMYLKLWDVGGQLSLRKLWQSYYASCHAIVFIIDSTDIGDGDLEHENNGRLDECRAVLEDVLQNSDAEGVPLLILANKQDREDCVEVVRIKEGLVKRVFEGEKSGGIRDSRVLPVSALTGTGVREAIDWIRSRVKWNKESRPPVMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0S799</accession>
    <name>G0S799_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peptide hydrolase</fullName>
            <ecNumber evidence="14">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CTHT_0036100</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Extracellular aminopeptidase that allows assimilation of proteinaceous substrates.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the peptidase M28 family. M28E subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="14"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694039.1">
        <property type="nucleotide sequence ID" value="XM_006693976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S799"/>
    <dbReference type="STRING" id="759272.G0S799"/>
    <dbReference type="MEROPS" id="M28.022"/>
    <dbReference type="GeneID" id="18257648"/>
    <dbReference type="KEGG" id="cthr:CTHT_0036100"/>
    <dbReference type="eggNOG" id="KOG2195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025866_0_0_1"/>
    <dbReference type="OMA" id="GMLQQDM"/>
    <dbReference type="OrthoDB" id="2214at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03879">
        <property type="entry name" value="M28_AAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000042">
        <property type="entry name" value="Peptide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF56">
        <property type="entry name" value="AMINOPEPTIDASE YDR415C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 16" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="8 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005130806" description="Peptide hydrolase" evidence="14">
        <location>
            <begin position="19"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="15">
        <location>
            <begin position="175"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGS21743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="407" mass="45739" checksum="E5CA1F000D6B822A" modified="2011-10-19" version="1">MKVSNASLLALLLPTVSARFIEPGETDRVMLYPDGIPEAPKSTQKFLIELAPGETRWVTEDEKWELRRAGRRFFDITDHQDLGRLRTASKKKSVFPETVTQQKAVNPLLEQLSKKQMEDHLTTFTGFYTRYYRSDEGRKSSEWLLSQVRQTIKDANAEGFVRAEPFQHSWGQNSIIATIPGQTNSTIVIGAHQDSINLFFPSFLAAPGADDDGSGTVTILEAFRVLLQSQDVLQGKAQNTIEFHWYSAEEGGLLGSQAIFSAYEKQGRDVKAMLQQDMTGYVKRTLDAGKPESVGVIVDYVDKNLTEFIKKVIKEYCTIPFVETKCGYACSDHASASKAGYPSAFVIESDFDDSDPHIHTTDDTISHLSFDHMLQHARMTLAFAYELAFTDFVALEEAKYFKHDDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7B9</accession>
    <name>G0S7B9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5'-deoxynucleotidase</fullName>
            <ecNumber evidence="8">3.1.3.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0036300</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.1.3.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HDDC2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.89" evidence="8"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694059.1">
        <property type="nucleotide sequence ID" value="XM_006693996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7B9"/>
    <dbReference type="STRING" id="759272.G0S7B9"/>
    <dbReference type="GeneID" id="18257668"/>
    <dbReference type="KEGG" id="cthr:CTHT_0036300"/>
    <dbReference type="eggNOG" id="KOG3197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039453_2_0_1"/>
    <dbReference type="OMA" id="PFFHMLE"/>
    <dbReference type="OrthoDB" id="10254258at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002953">
        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009159">
        <property type="term" value="P:deoxyribonucleoside monophosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3210.10:FF:000011">
        <property type="entry name" value="HD domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845:SF13">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0170">Cobalt</keyword>
    <keyword evidence="10 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="13">
        <location>
            <begin position="68"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS21763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="259" mass="29233" checksum="48EAB40E3B1DA3F9" modified="2011-10-19" version="1">MLTNLPDVTVVPNPNNNIVGQWTVEKVLDTIPTGKPVQGSTSPVPYFHILERLKTTKREGWRRLGIDRGESISDHMYRMAMLSMLAPPSLASRLDMTKCMKMCLIHDMAESIVGDITPVDGIDKPEKSRREASTMDFITKGLLGNVDEGKVGAEIRAIWQEYEDSKTLESLYVHDIDKMELLLQMVEYEKRGKGKLDLGEFAYVKTKIVLDEVKAWAEELMQEREEFWAGQAHIHGEQGVAGGVSPEKKAMQDAYYSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7H6</accession>
    <name>G0S7H6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribonucleases P/MRP subunit Pop8-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0028170</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693274.1">
        <property type="nucleotide sequence ID" value="XM_006693211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7H6"/>
    <dbReference type="STRING" id="759272.G0S7H6"/>
    <dbReference type="GeneID" id="18256855"/>
    <dbReference type="KEGG" id="cthr:CTHT_0028170"/>
    <dbReference type="eggNOG" id="ENOG502SCWV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115053_0_1_1"/>
    <dbReference type="OMA" id="QVKSYCT"/>
    <dbReference type="OrthoDB" id="5530243at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000171">
        <property type="term" value="F:ribonuclease MRP activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034965">
        <property type="term" value="P:intronic box C/D snoRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000294">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, RNase MRP-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020347">
        <property type="entry name" value="Pop8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049128">
        <property type="entry name" value="Pop8-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28173">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28173:SF1">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20976">
        <property type="entry name" value="Pop8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonucleases P/MRP subunit Pop8-like" evidence="2">
        <location>
            <begin position="50"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS20978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="166" mass="17958" checksum="DFE81FFDB67B58DF" modified="2011-10-19" version="1">MTTTSQHQHPTNRSPEAMDIDLPPSTFDKTKFIKTSKTRVLTTATLSHPPFSYAHLAVTQLPNDEKQQQPELELDALQVKSYLTSALRQFLGATGAAIPVDILLVKGQDAWVRVPREDLAAFAAAVTAFPGTSSDSGGTLLLQIKACGDWLGALIARASEGDVWTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7Q7</accession>
    <name>G0S7Q7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Putative asparagine-rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CTHT_0028470</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693303.1">
        <property type="nucleotide sequence ID" value="XM_006693240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7Q7"/>
    <dbReference type="STRING" id="759272.G0S7Q7"/>
    <dbReference type="GeneID" id="18256885"/>
    <dbReference type="KEGG" id="cthr:CTHT_0028470"/>
    <dbReference type="eggNOG" id="KOG4198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022834_2_0_1"/>
    <dbReference type="OMA" id="DWKCGEN"/>
    <dbReference type="OrthoDB" id="448399at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06133">
        <property type="entry name" value="ERI-1_3'hExo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12452">
        <property type="entry name" value="RRM_ARP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.10:FF:000021">
        <property type="entry name" value="MUTL protein homolog 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.10:FF:000024">
        <property type="entry name" value="RNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047201">
        <property type="entry name" value="ERI-1_3'hExo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034351">
        <property type="entry name" value="Nrp1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23111:SF40">
        <property type="entry name" value="RNA-BINDING PROTEIN INVOLVED IN HETEROCHROMATIN ASSEMBLY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23111">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="14">
        <location>
            <begin position="255"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="15">
        <location>
            <begin position="354"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="15">
        <location>
            <begin position="428"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="557"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="596"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="561"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGS21007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="615" mass="65929" checksum="C52948626B532E0F" modified="2011-10-19" version="1">MASQHQQTPAFKTDRYIVIHVATTCDEHGVYVTKDSAEVIELGWILLDANSLEELHRESILVKPVNTPITPLCTSLTTLTWEHVRNAGTFRDAINRFDAFVNEHLTSQNLDFVFVTLEAWDLRVQLPREARDKSVVLPPYLQHSRAFELRTEYQRWQQHHPESLPFGPSSLANICAALEVEPVQSSAPIKHNLPFHLQSLAPASPRRALEEALTLARVLRGLIRKSQPPHEHPDVLTRPMDARADVRAFLAERSKVLHLSGLPHDTTQSELESWFTQYGGRPIAFWTLRTPEQHKPTGTGFAVFSSHEEAAESLCMNGRALNEKAIEVSPSSSRVLDRAAEILTPFPPSKNRPRPGDWTCPSCGFSNFQRRTACFRCSFPAVTAGPAGELAYGYGYAPPMLPPPHHMAHHGHAGGHGRMGGSGVVPFRAGDWKCGNEVCGYHNFAKNVCCLRCGASRAGAAVVADSGYPSPMDPPSAYGMGQSSIGATPGPGPFGSAAAGFGSGAGYNQHFGGPPSTYALPSGLGGGAAPYPPLNAHFGPAPGSHSAGPFDSRAAEAAFQSAGNGPASAGPANNFYSQNESDPFAFLSSGISSLSVSNQDARQNGGSAPPSKSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7Y5</accession>
    <name>G0S7Y5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0037450</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694168.1">
        <property type="nucleotide sequence ID" value="XM_006694105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7Y5"/>
    <dbReference type="STRING" id="759272.G0S7Y5"/>
    <dbReference type="GeneID" id="18257783"/>
    <dbReference type="KEGG" id="cthr:CTHT_0037450"/>
    <dbReference type="eggNOG" id="ENOG502S0GM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_348543_0_0_1"/>
    <dbReference type="OMA" id="KCATIEA"/>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408938" description="VWFA domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="831" mass="90156" checksum="96EC08CAA1559642" modified="2011-10-19" version="1">MQRSLTTLIFGLAITHAAFSQQITDAPKIESVSGCAAVVETTAICSTCLTAACVVPVTITAGCGTCPVNPATIYRSHDCSQGCDGLGCRTVYTVVTSQGKECAFGTINEPVLLGQHNEHEMITRLAFQCPKGRKSDGVCFEPRSLDQLAGYHLHVLGWAIPGAGFNGAVGAPDTLDPIPEGPEAHCDDADYLDIPGYPQTRAQATARLQVCIDHLRTRFHQALVAAARLLDDRKRIREDMVDISSPLFGDCTYAFPKLQGDTSGRAKCRTLEGLGRALHGVQDFYSHSNWVDSADPNLPIGVSNPPGLGIAVTAPFLDLRATGPIPAHQIPINLSTGCFALPDTYPGVGECEGRITHHTLSKDNGVIHLDGSFGEVWLGSPRSRISDNFRRAVEAAVQSSRDTWAALQDAIRDRYGAIRGNLMICALIRDNPIKDCRNRTVAIALDKSWGSGVNGAIQLERIFAQELNSRLAMHALDKVAVLEFDEAPRLVYPMGYPKFAIIGSSNPVGYRRIDNALDLAIAENINAQPETYADRGAVLLLCSRSKSRESSSNVLAQVKRAKDEGIRVHYACIDIQETTRQGIESNNMWDDCGLEMLRNALGTGGVVAIVTIPDIHTPSKLIDLIMNRGLTATDDVSSPDNMRLYSGIVLTDLVSPAIQEKVFEYPVSSGEQVTFTIRYVMASREYQSDACLTVEVRDKGFGTPVSAHTLCRGEPPWVLEYVVEKANNLVFIVQYDGSTGKGVDTFDNEGIYFVVGVDSNLFDKVEITSEIAMSSLGTAVAAELPRQQPAKPFLAGTTYGNLIGMTPRDRGNPFSIQDHMDQDLNCRMRCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0S827</accession>
    <name>G0S827_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gfo/Idh/MocA-like oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0029150</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693370.1">
        <property type="nucleotide sequence ID" value="XM_006693307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S827"/>
    <dbReference type="STRING" id="759272.G0S827"/>
    <dbReference type="GeneID" id="18256953"/>
    <dbReference type="KEGG" id="cthr:CTHT_0029150"/>
    <dbReference type="eggNOG" id="ENOG502QUH1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039854_1_0_1"/>
    <dbReference type="OMA" id="ININQAK"/>
    <dbReference type="OrthoDB" id="2127032at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000030">
        <property type="entry name" value="NAD binding Rossmann fold oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000778">
        <property type="entry name" value="NAD binding Rossmann fold oxidoreductase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF6">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="69"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="385" mass="42103" checksum="0756393661557273" modified="2011-10-19" version="1">MKPLNVLMVGTGEYTTGFVGGGASSSDKKIGVVGLCMFDLRRRGKVGKLGMVGVNGTKFPAIRKHLYENISLVYNGMDTSFESWPADDTIDPEAYKKAIDALSPGDAVTIFTPDTTHFPIALYAIERGIHVMITKPVVKLLEHHVALIQAAEKHGVFVYMSQPKSQLETFKAWAGVDSDISYYLNSHHIDICDSMVSPLGYVPVKVSASASKGVATSLGCNEATEDTISLLVHWEKKGDPTKHATAVYTASWTAPQRAGVHSNQYFHYLAKGGEININQAKRGYDVAEDSAGQVVWYNPFYMRYAPDENGNFNGQSGYGYVSIEKFVDACRSINAGISKPADYDNKGLPTLKNTIATTAILEAGRRSIDENREIRIESGDSWKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0S887</accession>
    <name>G0S887_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative phosphate metabolism protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0037950</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694217.1">
        <property type="nucleotide sequence ID" value="XM_006694154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S887"/>
    <dbReference type="GeneID" id="18257833"/>
    <dbReference type="KEGG" id="cthr:CTHT_0037950"/>
    <dbReference type="eggNOG" id="KOG1134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002458_2_1_1"/>
    <dbReference type="OMA" id="DPTQVIW"/>
    <dbReference type="OrthoDB" id="1076608at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF26">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G10920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="486"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="534"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="574"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="600"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="646"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="674"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="11">
        <location>
            <begin position="15"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="189"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="394"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="10">
        <location>
            <begin position="774"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS21921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="874" mass="98925" checksum="4E496D5364478CB7" modified="2011-10-19" version="1">MSEVDKVPPASLSGMLSTLAPVAVMSGAYLAIFLVLRRTQRRYYAPRTYLGSLRESERSPPLPNGFIDWFFSFWKIPDIYALQHQSLDAYLYIRFLRQAFIMMLVGCLVTWPILFPVNATGSGRQRQLDILSYANIDNKTESDRYYAIVFVSWAYFGFIMYMIMRECIFYINLRQAFLLSPFYSERISSRTVLFTDVPEPYLTEAKLRRVFGSAVNRVWITSDTSEVDDLVTERDKVAMRLENAEVNLIKLANKLRQRAIKNGTDTEKAPIVGDHANEESGSVAARWVPAEKRPTHRLGPLGLWGEKVDSINWCREQLARLVPEADAAQAKYRTGGYKRINAVFIEFKTQIDAEVASQTLAHHLGYHMQSYVGIRPDEVVWDSLAIPWWQKVIRRYIVFGFIFAMILFWAIPVAFVGLVSNVNYLATISWLEWIKDIPAVILGVITGLLPSVMLSILMSLVPIIIRLCGRIAGEPSQSRIELFTQNAYFAFQVIQVFLVTTLSSSATAVAKQIVDNPTSATSILANNLPKASNLYISYFIVQGLSIATSELTQITGFVIFYLMYKLLANTPRALYQKWTTLSAISWGSTLPIYTNIAVIAITYSCIAPLMLGWATIAMFLFYIAWRYNVFFVTDTQVDTRGLIYPYAIKQLFTGLYLAELCMIGLFGASASPGPLILMVIYLVFTALFHISLNSSLNPLLYNLPRTLLSEEEEIRLMDPEAGVGPSRSADETAEKTEVKDLNDDGVVDDTEAHVAAARQAAKVTDRSGNFLTRFFQPWIYANYYVLRKLVPRHIQLEQYSEEVASNAYHPPNTKSPAPLLWIPEDPAGVSKQEVAHTSRVIPITDEGCTLSEDGKLIWDKERTRPPVWEEKIYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8S9</accession>
    <name>G0S8S9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0040210</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
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        <property type="protein sequence ID" value="EGS20282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694431.1">
        <property type="nucleotide sequence ID" value="XM_006694368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8S9"/>
    <dbReference type="GeneID" id="18258059"/>
    <dbReference type="KEGG" id="cthr:CTHT_0040210"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="OMA" id="GWGTSYV"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF66">
        <property type="entry name" value="MFS HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
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    </dbReference>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="400"/>
            <end position="426"/>
        </location>
    </feature>
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        <location>
            <begin position="39"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGS20282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="538" mass="60764" checksum="D6D71F1DD99F1226" modified="2011-10-19" version="1">MPRVISDGASAEFEPVTEIPRFQRVYWTKEPHLRKLYGLATLLMVASATTGYDSMLVNTSQQIDRWNWFFFPETRENPSIADPVLNSKLAILVNMFNIGSIVSFFITPYVADHFGRKPAIVWGCLCMVVGGLLTAFCNGYGMYMGGRFILGFGNSLAQMASPLLLTEICHPQHRGPVTAIYNCLWNAGALLVTCIAWGTGNIKNDWSWRSITLLQILPSLVQLAGIWAVPESPRYLINKERYDEALHILTKWHAGGDPHNATVHFEFREIRETIRIQKELDRTTSYRDFLRTRGNRWRLAIIVSLGIISQYSGNALFSNYMNAIYLGAGIKKQNQKLAMSTGKTILDLIVTISAALSVDRFGRRPLFLISMCGMVLSFACWTVTGAVYENSGETNVASGYAQLVFIWIFGVFYDIGFSGLLVAYALEVLPFHLRAKGMMIMNITVQAFLAIGNQTNKLAWERLPNHWNFMLFYTLWDLCELVFVWFMYPETKGPTLEEIARIFDGDGGVANIDMHSIHKDLYHHVARELDDDLPGKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9H2</accession>
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            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">CTHT_0045880</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006694905.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="18258626"/>
    <dbReference type="KEGG" id="cthr:CTHT_0045880"/>
    <dbReference type="HOGENOM" id="CLU_1885526_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409389" evidence="2">
        <location>
            <begin position="22"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS20083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="135" mass="14578" checksum="E8EFDD19ED6AA120" modified="2011-10-19" version="1">MHLPLILQLLATGLFTMVAMAQEVLNIPDVAQSVLSDIEAQLPTVPVEQATSMVLAQATIVPGADTVLQETGDVPNAVKAAVDDILAQGADILTAVTDNTNLRHRRRGYRRADHGNHKRGADLGKNFEDLPFQKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9J8</accession>
    <name>G0S9J8_CHATD</name>
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        <submittedName>
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        </submittedName>
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    <organism evidence="6">
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20109.1"/>
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    <dbReference type="OrthoDB" id="775356at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF60">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN RASKOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="564"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="4">
        <location>
            <begin position="764"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="205"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="378"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1162"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1327"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1177"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1211"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1224"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1238"/>
            <end position="1260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS20109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1352" mass="148510" checksum="546C66253699DEC2" modified="2011-10-19" version="1">MPRERGLTSPSGPLEDRPASMGPLPHNPERQNQTQMGSPLPPLTELPSSSVSTTQRASTSNLRSAFRQTIRAVTPEPAEASPGSHVPEGFTSAGVSQMLHDLSSASPQTSPRTIPSAPVNMPAKRQGVVFQDDFAGSFDSTSSSPPARPQSFRPRTHTMDGSFRQQLAPATELRNRLGSFSSATSLPVTDDMRMASLQSPVESYKSMDFIPPGSSGPSKDKKGGARSRLSKRPSSRPSSPLSSLPPSVDSLPLPIPTTDANKILLLMKNLCGRMRGEIEYQKELGSPWVGGMCYIEEEKGSLMFDPGDIGPFHTALISDLRGCRVVPVEQSEATGQCLEICSPHLGVAILLRPLVPEEFDLWLAALLCWQQLRPANSKSQSKASKDSPAPPGHTEMKRRVSSNGLREKESAIIKVGKVMLWDRGAALSPRAIVRRPSTRDLRSLSTCWRRVSCILHDNGELKIMTENDMTVLSVIELSQLARSAIQQLDRSVLDEDYCLAIFPIYSFTSTQLSIFRPVYIALESRTLFEVWYVLLRAFTIPDIYTFDPTRGEPLTEVVNLAAEPPGETFRVEKTITLRVTEAKIRSRTWMGEGTPPERWSKSNNDDAGLVGNYLAEVILDGEVRARTPTRAGTKHPFWREDYEFTDLPVALPFVSVLLKRVNDNTESFARQIQATLGLAKPSHPTEILCGCVDIPLHEIECGKDYEQWLPIYDDKQGSVGQMLVKVRHEELVVFLGRHYNDLSELLHKFDSGLAAQIAEALPGNLRRVAEIFVNIFQVTGRADEWLMNMVEEEIDGIGNQTALRKGRFSTRLKSNDSVESTVEREMLVRELGKSLQGEANLLFRGNSLLTQALEFHMRRLGREYLTETLGEKIVEINESDCDCEVDPSKVAHSDDLHKNWNNLIQFTTEIWEAISVSATRLPPELRQILKYIRAVAEDRYGDFLRTVTYTSVSGFLFLRFLCPAILNPKLFGLLRDHPRPRAQRTLTLIAKSLQALANLSTIGKKETWMEPMNRFLTAQRQAFKDFLDTVCAIPADRRKSAVPPSYSTPNTIMGRLAPLAREGFPSLPYLIDQPRNFAALVKLWADNHPPSASSSQVYEGDLLKFHNICIELHQRATACLARIDALRNAEGASQPADDVSGLADVMDRITVGDMFNLSAYGGSNSGLPDTEGPPPKSSGSDVDPTTASTSSSRPFGAISIGSPRDLKQLYRSESNSTNRESTSLRQVSRSSEVFPQPTGSGNSSNSSGSASSTVRSLRSGIHPRKLLSGFIRKARSNTSDGNGSGPSPEASPTLINTSVTPVEAATSTPTTITTPATSANATIISSPQAGSAAVSAMKPFSLPIIPKEHDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9K7</accession>
    <name>G0S9K7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">GPI inositol-deacylase</fullName>
            <ecNumber evidence="3">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0046240</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GPI inositol-deacylase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="3"/>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695003.1">
        <property type="nucleotide sequence ID" value="XM_006694940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9K7"/>
    <dbReference type="STRING" id="759272.G0S9K7"/>
    <dbReference type="GeneID" id="18258662"/>
    <dbReference type="KEGG" id="cthr:CTHT_0046240"/>
    <dbReference type="eggNOG" id="ENOG502QQNH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015737_0_0_1"/>
    <dbReference type="OMA" id="WGDYKGT"/>
    <dbReference type="OrthoDB" id="5592486at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-ab_dom-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07819">
        <property type="entry name" value="PGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GPI inositol-deacylase PGAP1-like alpha/beta" evidence="4">
        <location>
            <begin position="154"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU365011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS20118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="352" mass="39608" checksum="3C41CD6AB8525B54" modified="2011-10-19" version="1">MTRLVAVCYRSHTAATTSVQGVWPNARFSTNTYHRATFRARAPALRCFGAYKPRCRQIVLTDARIKGLGREIADEYAFLKDRYKTPRYPVVLAHGLLGFAELRLAGSYLPSIQYWRGIKEALTTNNCEVITAQVPPSSSIEKRAAKLAEDIVAQAQGKSVNIIAHSMGGLDARYMISCLQHPGVDVKSLVTVATPHHGSPFADYMLELIGPRYLPRLYKLWERTTGWEPSAFAQLTTTYMTEEFNSRTPDDPAVRYFSYGAMVKDRPPLLSPFRLSHRVIEEVEGPNDGLVSVESSKWGVYKGTLLGVNHLDLINWSNRLRYTAQKWMGRPPTFNAIAFYLDIVDMLAREGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9L7</accession>
    <name>G0S9L7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ureidoglycolate hydrolase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0046340</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(S)-ureidoglycolate = urea + glyoxylate</text>
            <dbReference type="Rhea" id="RHEA:11304"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57296"/>
            <dbReference type="EC" id="4.3.2.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695013.1">
        <property type="nucleotide sequence ID" value="XM_006694950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9L7"/>
    <dbReference type="STRING" id="759272.G0S9L7"/>
    <dbReference type="GeneID" id="18258672"/>
    <dbReference type="KEGG" id="cthr:CTHT_0046340"/>
    <dbReference type="eggNOG" id="ENOG502S1JQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070848_0_0_1"/>
    <dbReference type="OMA" id="DCQEVAF"/>
    <dbReference type="OrthoDB" id="10266039at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004848">
        <property type="term" value="F:ureidoglycolate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050385">
        <property type="term" value="F:ureidoglycolate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20298">
        <property type="entry name" value="cupin_UAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.480">
        <property type="entry name" value="Ureidoglycolate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047233">
        <property type="entry name" value="UAH_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007247">
        <property type="entry name" value="Ureidogly_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024060">
        <property type="entry name" value="Ureidoglycolate_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21221">
        <property type="entry name" value="UREIDOGLYCOLATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21221:SF1">
        <property type="entry name" value="UREIDOGLYCOLATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04115">
        <property type="entry name" value="Ureidogly_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="153"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS20128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="29045" checksum="7F2B277917BE808F" modified="2011-10-19" version="1">MSSPIMLQFSGPPIVIEAIPLTREAFAPFGDVIENPRPTTNPSSFSSLPLLSRSSLPFNPVPANQGSAIKYQHVSRPINLYSQAPSGRPGEPVMNIFVCAARVPLPPTAEGPPSEFHVSILERHPYTTQTFTPLTADPSARYLVIVAPTLPPDSPGAANLSSDGPDAEPSPALPTPASIPSGASYPRPLPGPGMPDLKQMRAYVATASQAVTYGAGTWHAPMVALGMEGTAVDFVVSQFANGVVVEDCQEVVFGPGVTVKVPPSAVSGKREARAFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0SA08</accession>
    <name>G0SA08_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0040580</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694465.1">
        <property type="nucleotide sequence ID" value="XM_006694402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SA08"/>
    <dbReference type="GeneID" id="18258096"/>
    <dbReference type="KEGG" id="cthr:CTHT_0040580"/>
    <dbReference type="eggNOG" id="ENOG502RYQD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_621123_0_0_1"/>
    <dbReference type="OMA" id="LADKECW"/>
    <dbReference type="OrthoDB" id="3056235at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF18">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="7">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="166"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="327"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="252"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS19580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="413" mass="45004" checksum="4AF52145EEB9663E" modified="2011-10-19" version="1">MMLSSLSPNDYELRGTERKPIDPPPIVRLLVNPRKDPNRTFLQNPYLILTARLIPKGDDEPDSGGGPKESDLTGTLVSSLYSLKDTDNTQGGFFVFGDLSVRRVGTYRLLFMLYELRLADKECWLLSRTVSDPFIVYATKSFPGLAESTFLTRSFSDQGVRLRLRKDSRSVSSKKRSLGMATQDQMRPPQGSYGYLPHDTSHDLSSPNGSTHHLRQLDRTRSAIGSQSGYYGDSPQMRPGEYGSGSYGYSSYDDKPTKRARLDGAPDDSPHGYESDYHPYAQAGPRTVPDPLTSIYPMSTSYPVPAQPALAGLPMPSPYGSIPRLDTQHLPPHSPAAPTSATSTFSPEPRRSPVTSYPYGTQHTPTAPPPPAMFAAPTAPTSLPYHAANPAPLPHPNGLGIALPGMGLEAVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAF2</accession>
    <name>G0SAF2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0042060</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694609.1">
        <property type="nucleotide sequence ID" value="XM_006694546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAF2"/>
    <dbReference type="STRING" id="759272.G0SAF2"/>
    <dbReference type="GeneID" id="18258244"/>
    <dbReference type="KEGG" id="cthr:CTHT_0042060"/>
    <dbReference type="eggNOG" id="ENOG502S8NQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_6_1_1"/>
    <dbReference type="OMA" id="IEVVCHQ"/>
    <dbReference type="OrthoDB" id="10249419at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07262">
        <property type="entry name" value="VOC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35006">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14830)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35006:SF2">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14830)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="2"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="183" mass="20560" checksum="CF87C8E8D5FCBEBD" modified="2011-10-19" version="1">MPINHVALPTTPRTHTRMRAFYQTILSPLGYTIYKEQANLYVGFRPRNGGPDFWLHSTCEEVAAQLERDGYLFNSSKDKEEGKKGLTTHVAFDAGGVKEVERWYKIAVQAGGIPNGEPGERPQYAKGYYAAFVLDPMGNNVEVVYFNPWWLQLIKAAPCVLFTVFGAVAGHFAMRWARNAGWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAK0</accession>
    <name>G0SAK0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytoplasmic tRNA 2-thiolation protein 1</fullName>
            <ecNumber evidence="6">2.7.7.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cytoplasmic tRNA adenylyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">NCS6</name>
        <name evidence="6" type="synonym">CTU1</name>
        <name evidence="11" type="ORF">CTHT_0042560</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="6"/>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694657.1">
        <property type="nucleotide sequence ID" value="XM_006694594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAK0"/>
    <dbReference type="SMR" id="G0SAK0"/>
    <dbReference type="STRING" id="759272.G0SAK0"/>
    <dbReference type="GeneID" id="18258294"/>
    <dbReference type="KEGG" id="cthr:CTHT_0042560"/>
    <dbReference type="eggNOG" id="KOG2840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026481_1_3_1"/>
    <dbReference type="OMA" id="KPVRGIC"/>
    <dbReference type="OrthoDB" id="198857at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002144">
        <property type="term" value="C:cytosolic tRNA wobble base thiouridylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="CTU1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03053">
        <property type="entry name" value="CTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056369">
        <property type="entry name" value="CTU1-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032442">
        <property type="entry name" value="CTU1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000541">
        <property type="entry name" value="Ncs6/Tuc1/Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054306">
        <property type="entry name" value="TtuA-like_LIM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020554">
        <property type="entry name" value="UPF0021_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807">
        <property type="entry name" value="ATPASES OF THE PP SUPERFAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807:SF12">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22082">
        <property type="entry name" value="TtuA_LIM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16503">
        <property type="entry name" value="zn-ribbon_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01263">
        <property type="entry name" value="UPF0021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="2-thiouridine synthetase TtuA-like N-terminal LIM" evidence="10">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="8">
        <location>
            <begin position="53"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Cytoplasmic tRNA 2-thiolation protein 1 C-terminal" evidence="9">
        <location>
            <begin position="365"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="57"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR004976-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS19772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="398" mass="43970" checksum="8EA3FBDB33368B45" modified="2011-10-19" version="1">MAPSPCSKCKTERAIIKRPKNHAKLCKACFIQVFEDEVHHTIVSSKLFYPGEKVAIGASGGKDSTVLASVLKTLNERHNYGLKLVLLSIDEGIKGYRDDSLETVKRNSVQYDMPLKIVSYEELYGWTMDQVVETIGKKNNCTYCGVFRRQALDRGAKMLGIKHVVTGHNADDVAETVLMNLLRGDLARLARSTSIVTGDSRSDVKRSKPLKYSYEKEIVLYAHHKKLDYFSTECIYSPEAFRGSARGLIKQLEKVRPSAILDIVRSGEDMARLVPGDSSSCACDGQITAFMGPTEDDVGGCGSQNGSTPGNEMAAMDKQLRENEEHASLEDDVAKSIAKESGQQRELPLRTRNGMVKGGTRQVLGNCKRCGYMSSQDICQACMLLEGLNKNRAQIQIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAS6</accession>
    <name>G0SAS6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0047590</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695128.1">
        <property type="nucleotide sequence ID" value="XM_006695065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAS6"/>
    <dbReference type="GeneID" id="18258797"/>
    <dbReference type="KEGG" id="cthr:CTHT_0047590"/>
    <dbReference type="HOGENOM" id="CLU_000288_34_10_1"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS19306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="134" mass="15234" checksum="0EA7B55E35261AB7" modified="2011-10-19" version="1">MDAYTRHEKHRSQPLLSDLEEMFHNVTTLYKDGVFVIVDALDECQMSDNVRSKFIEALQRLHSRGTNVNLLATSRPLPDIVEAFDGHSCLEIVAQKDDIERYMRNQLSNLRAVSKSPNLQDDIIDCIVSVADGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAX2</accession>
    <name>G0SAX2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3 6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0048110</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3 6"/>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695174.1">
        <property type="nucleotide sequence ID" value="XM_006695111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAX2"/>
    <dbReference type="STRING" id="759272.G0SAX2"/>
    <dbReference type="GeneID" id="18258849"/>
    <dbReference type="KEGG" id="cthr:CTHT_0048110"/>
    <dbReference type="eggNOG" id="KOG0549">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013615_8_1_1"/>
    <dbReference type="OMA" id="PKTCDIQ"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044609">
        <property type="entry name" value="FKBP2/11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779:SF7">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409008" description="peptidylprolyl isomerase" evidence="7">
        <location>
            <begin position="21"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="8">
        <location>
            <begin position="41"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS19352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="144" mass="15575" checksum="FCD4835DFCEC9619" modified="2011-10-19" version="1">MRNIFLSFSFLASAAVGVLASEDLKIDVTLPIECDRKTQKGDVINVHYKGTLKSNGQKFDSSYDRGVPFSFKLGAGMVIKGWDEGLLDMCIGEKRTLTIGPSYGYGQRAVGPIPAGSTLVFETELIGIEGVPKSADTSEEHKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0SB25</accession>
    <name>G0SB25_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0048640</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695227.1">
        <property type="nucleotide sequence ID" value="XM_006695164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SB25"/>
    <dbReference type="STRING" id="759272.G0SB25"/>
    <dbReference type="GeneID" id="18258902"/>
    <dbReference type="KEGG" id="cthr:CTHT_0048640"/>
    <dbReference type="eggNOG" id="ENOG502QQEE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022556_0_0_1"/>
    <dbReference type="OMA" id="TTHRNKF"/>
    <dbReference type="OrthoDB" id="5240840at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="649"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="565"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="649"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS19405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="757" mass="78591" checksum="3A870D5DFB122F49" modified="2011-10-19" version="1">MASNNLPVGAFLTSIDGRRCTAIPRLAVTPSSLTTTSTTQQIATFTTFSTQSQPTSSNNNNNNSPSTDIVAAPAQGGDENRATVPISTSLPLLFPSSSSSSSSSSSSSTTTPTFITIITTAFPTSQAGVMQAQESQSLAPLNPNPAAVPSITALADDLSSSSQSSLVQSSQADAVIASSFSTLLSSPLDQGASSSETPFFDGSPSTLPILATSPVVAGPGVQPTVGNDVPSPQTRSNDVAASVATTAAESSETTTPASPNSRAIRSTVAVAAGVIGGVLALSILAFLIWWWRRRVLRKRRSTLLTPLDAPPAPFGTGSREKPTPGGSGGGGGNYVITRDSIGPTPVTERLREAIGLKWKSLRGHWRNKTAPSVDLDRGTSQFLDGGKSANFSSQPNPTAKGRLQGWWSGIKDRGKPGRFPHLRSRSKDGDTGPTMLEKRQKKAALGSKPDFLALLGMTGQELERETQRRRESLSRAAAANDDDGNKESAENPFSDDNAITIAHPSAAPPPLALGSKGPNPPPPAAAAPNGMGRNPFGDENAIRDDSQLPAVNRPQYADPRRRSQSLSGPSVSAGVGVGLSRNPSSATNTNRASSRYYAVGAGGSPYYARDSVSSLATTTTTGAAGGRSKFRSDPFDLERPELLRRAAALQAQSQSTTTQNNGSIGSIVEPVPVSPLAEEENSNLDNDEGIEVRRPEVARVARAAKVESYTSKYSSGVSSVTLTAGRFAEWREPGPDVGPGSGALGNSGWGVEVGRAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G0SB41</accession>
    <name>G0SB41_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">threonine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CTHT_0048800</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695243.1">
        <property type="nucleotide sequence ID" value="XM_006695180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SB41"/>
    <dbReference type="STRING" id="759272.G0SB41"/>
    <dbReference type="GeneID" id="18258918"/>
    <dbReference type="KEGG" id="cthr:CTHT_0048800"/>
    <dbReference type="eggNOG" id="KOG1637">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008554_0_1_1"/>
    <dbReference type="OMA" id="WYADGMY"/>
    <dbReference type="OrthoDB" id="5423599at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01667">
        <property type="entry name" value="TGS_ThrRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00860">
        <property type="entry name" value="ThrRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000003">
        <property type="entry name" value="Threonine--tRNA ligase 2, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000006">
        <property type="entry name" value="Threonine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000005">
        <property type="entry name" value="Threonyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047246">
        <property type="entry name" value="ThrRS_anticodon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF46">
        <property type="entry name" value="THREONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGS" evidence="15">
        <location>
            <begin position="70"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="339"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="579"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="583"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGS19421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="788" mass="90153" checksum="1D1FB2D60B42311B" modified="2011-10-19" version="1">MEQVTEAMQKTAISGAEKKGKKEKKGAAPDPAASGPLELDPWPQFIQDRIELFDKLYKEYQEEIAKKPREPIEITMPDGTVKHGTSWETTPAEIAKSISNSLYKRTVVARIDGETLWDLDRPLEKSCKLELLDFNDEQGKFVFWHSSAHVLGEACERRFGCSLCIGPPVENGFYYEMALPGGAAVQSSDWAPLEAIVQKIVKEKQQFQRLEMTKEDLLKMFAYNPYKVHIIKDKIPDGTKTTVYRNGPLIDLCRGPHVPDTSRIEAFAIMKNSSSYFLGDANNDSLQRIYGVSFPDKKQMAAHKKFLEEAAKRDHRVIGRQQELFYFEECSPGSAMWLPHGMRIHNAIMEYIREEYWKRGYDEVMTPNMFNVALWEQSGHLAHYKEDMFLLEVDKEQFGLKPMNCPAHAMMFRHRERSYKELPLRFADFGVLHRNEASGALSGLTRVRRFQQDDAHIFCREDQIKQEVADLFDFMASFYGMLGLTFKLKLSTRPEKFMGDIETWNRAEARLKEALDEFAASQNGVSWELNPGDGAFYGPKIDIAVLDCLNRPWQCATIQLDFQQPINFSLEYQTAEGAQTAAQKDKEEKKEQPKAEEAKPAVDGEKKEDAAEKKDGKKKPLVPKKPLSPGCARPVMIHRAMAGSIERFTAILCEHFAGKWPFWLSPRQVLVIPVGMGFLDYAKEVAAILKQARFYVDVDSSGNTLQKKIRNGQLAQYNFIFVVGDEEKRNRTVNIRYRDDTSTQARDVPYPLDEAVEKLKKLKADRGMYNPFPHVAKKKEEGEKKEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G0SB87</accession>
    <name>G0SB87_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mtf2-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0049280</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695289.1">
        <property type="nucleotide sequence ID" value="XM_006695226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SB87"/>
    <dbReference type="STRING" id="759272.G0SB87"/>
    <dbReference type="GeneID" id="18258966"/>
    <dbReference type="KEGG" id="cthr:CTHT_0049280"/>
    <dbReference type="eggNOG" id="ENOG502S7AT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028481_0_0_1"/>
    <dbReference type="OMA" id="GPLYPAY"/>
    <dbReference type="OrthoDB" id="2444174at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043837">
        <property type="entry name" value="Mtf2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040009">
        <property type="entry name" value="Mtf2/C5D6.12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39468">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39468:SF1">
        <property type="entry name" value="MTF2-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19189">
        <property type="entry name" value="Mtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mtf2-like C-terminal" evidence="2">
        <location>
            <begin position="268"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS19467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="479" mass="53794" checksum="E2A107E2AF7A0A19" modified="2011-10-19" version="1">MSTTVMPFLYQTRTLQRLSRPGSAPRTLRMLLHSSATLRYPRAHSRRPKRTDNTIPFELPEGYQPPDSETPAFVEVDPETGLRSTITPSERAAFSRIFEEIAAKRAAQAAAAGIPPAGTTSAPQTAANAVPSRPDQSFTDVDDFSIRTKEPDHNAFRDTINIIVQDAAEVHTNAKRQLGKTFEPLHPLGQLTAATEWEKALLRFPPSLRQAARIALGTMEEDAAAEKAPPPSTTHPIHDEIVNEETKLGAQIDVALDPLSTPVKNEALRRAERRRVEAKMLQCKTDFELWDVLEEEVFPMVEKLGLDEESTKAATKNGKRGRGKRKDKLPVHIYGPLYPAYLMAALRLLDTRFARSSPLALQVLPRVKELGLASYVLGVSTPFYNELLRIHWKRHGDPRAVFDLLEEMRAVGLYCDEVTKDIVLNIQQYLDASAKGKEGPFLGELATLPEYEFALMPRARHWLKAIETQMWERKQDLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBB9</accession>
    <name>G0SBB9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cystathionine gamma-synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0049670</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695321.1">
        <property type="nucleotide sequence ID" value="XM_006695258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBB9"/>
    <dbReference type="STRING" id="759272.G0SBB9"/>
    <dbReference type="GeneID" id="18259005"/>
    <dbReference type="KEGG" id="cthr:CTHT_0049670"/>
    <dbReference type="eggNOG" id="KOG0053">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011302_1_0_1"/>
    <dbReference type="OMA" id="PKGMCAI"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003962">
        <property type="term" value="F:cystathionine gamma-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051750">
        <property type="entry name" value="Trans-sulfuration_enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699:SF1">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="494"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="500"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="519"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS19499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="642" mass="71050" checksum="DE173003BF455CDB" modified="2011-10-19" version="1">MFNLVTSSPMFIGQQRASHSPPTNAISVQLPTWADTIGWAQRDPRVLDAMKTGYPRFFIPRSVNTLCERLLGMLEPEPTENLKTRMALAWASLRHALYCVRFLRNNHTALGHESGVVRLWRVSWTGGGRLVGDENKDLEALCNDPEPSEANYIGEKDIYLMTFPEKEMFALGKAAWQHSGFGISSRRAQYWLDHAPFLTQQPKMSLPSAKEIDLRVTHARTVIRRRIAAAHSTPSLSVSEYDVYLFPTGMTSIAEASLAALSLTSNSSTYKGVAIYGFPYVDTYKLLSVFFSHPTILYKPSPSDLSSLLATASSSTPFRMMVTEFPGNPLLQSPPLRELYSAARKAGFPVIVDDTVGTSANLAVLSACDVVCTSLTKMFSGGCNVMGGAVVISQQSAFHTRLKARLEKVKGEGDSAWFWQDVLQMEENSRDFVGRVKKAGENAARMVRLLRNYQRSETNLEGIVEEVYYPWGSGTQHYYDEFLRPLTANGTLTAANSDSKLPDKDGDSSRDSKVDTELTSRNGYSHGSSLNSLTDSTEHVPSGYGFLLSFRLSTPILARAFYDALSVAKGPSLGTNFTLCCAYTLLAHYKELEWAAGYGVVEDLVRVSVGVEEWDWLKERVSRALETAKTMAGKDEDGAKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-12-14" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBF5</accession>
    <name>G0SBF5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0050090</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695357.1">
        <property type="nucleotide sequence ID" value="XM_006695294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBF5"/>
    <dbReference type="GeneID" id="18259047"/>
    <dbReference type="KEGG" id="cthr:CTHT_0050090"/>
    <dbReference type="HOGENOM" id="CLU_2196654_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS19535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="108" mass="12305" checksum="274E2A6D42914B26" modified="2011-10-19" version="1">MNNDFFDNNSESLFVTPHKRPAKPLCKFSPSSDIDCLHHGYRTHFEEHPRIEHARPSQLTTQKLKGAFSEDGSLHKSVSQISEKTAQKFALRTIPNEFKDVPKAQDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>G0SC05</accession>
    <name>G0SC05_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Alpha-aminoadipate reductase</fullName>
            <ecNumber evidence="6">1.2.1.31</ecNumber>
            <ecNumber evidence="5">1.2.1.95</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">L-aminoadipate-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CTHT_0055440</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+) = L-2-aminoadipate + ATP + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46936"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.2.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12308"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>(S)-2-amino-6-oxohexanoate + NADP(+) + H2O = L-2-aminoadipate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12304"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.31" evidence="6"/>
    <dbReference type="EC" id="1.2.1.95" evidence="5"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695876.1">
        <property type="nucleotide sequence ID" value="XM_006695813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SC05"/>
    <dbReference type="STRING" id="759272.G0SC05"/>
    <dbReference type="GeneID" id="18259582"/>
    <dbReference type="KEGG" id="cthr:CTHT_0055440"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_19_1_1"/>
    <dbReference type="OMA" id="HEIFHKN"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004043">
        <property type="term" value="F:L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000787">
        <property type="entry name" value="L-2-aminoadipate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014397">
        <property type="entry name" value="Lys2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03443">
        <property type="entry name" value="alpha_am_amid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF1">
        <property type="entry name" value="L-2-AMINOADIPATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001617">
        <property type="entry name" value="Alpha-AR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="19">
        <location>
            <begin position="630"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGS18931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1176" mass="131512" checksum="886E722A1AA6CA0D" modified="2011-10-19" version="1">MAQLPDPTVDLDWSGYVGSIQEHFRAQAEAHPDRTCVIETKSSTTPERRFTYRQIYEASNTLAWYLHKAGITNGDVVMIWAHRSVDLVVALMGILSSGATMTVLDPAYPPARQKIYLEVSQPRALLRIGRATDENGPLAPMVQKYIDDELQLKTEVPELRLRDDGILYGGEVDGQDIFASVRHLASAPPDVIVGPDSNPTLSFTSGSEGRPKGVLGRHYSLVKYFGWMAKRFNLSSESRYTLLSGIAHDPVQRDIFTPLYLGAQLLVPSREDIQHEKLAEWFREHKPTVTHLTPAMGQILVGGATAEFPELEHVFFVGDVLTTRDCRALRRLAINANIINMYGTTETQRAVSYFEIPSRARDPDFLDRLNRDTIPAGKGMENVQLLVVNRDDQKTMCKVGEVGEIFVRAAGLAEGYLGDPELNAKKFLMNWFVDNQKWVEQDQKINKNEPWRRYYKGPRDRLYRTGDLGRYLESGDVECVGRADDQVKIRGFRIELNDIDSNLSQNPLIRDCKTLVRRDRNEEPTLVSYIVPETREWQRWLQDRGLADVEDEGVEMGPVRVFLKKYRRMQTEVRDHLKTRLPTYAVPSIYIVLNKLPLNPNGKVDKPNLPFPDVAERVEDASEEDLKNWESLTETEKTVAQMWADLIRGLNPKTVKRDNSFFDLGGHSLLAQQFLLSVRKKLGTDVPIGTLYEHASLAGFSAQVDKLKSHDAGKVGPEAGEAAYSKSLDELLHQLPAQYQAVNLDAFNSAEKLTVFLTGATGFLGSYLVREIMERTAKPVKLIAHVRGVKEPSAAFTRLRRSLQGYGLWKDEWSSRLSAVVGDLSQPNLGMDDATWQTLAQEVDVIIHNGATVHWVKRYQDMMASNVLSTVDAMKLCNEGKPKVFCFVSSTSVLDTDYYIKLSEEQTRTGQGAVLEEDDMEGSRTGLGTGYGQTKWVSEQLIRAAGKRGLVASIVRPGYILGDSETGVCNVDDFLIRMLKGCIQLSARPRIINTVNAVPVNHVARVVVASAFNPISQGANVIHVTAHPRLRMNEYLSILEYYGYLTPEVSYDEWKVELEKFVSAGALEKDQEQHALMPLYHFCMNDLPANTRAPEMDDRNAVKVLKLDADRWTGVDESTGAGITREDVGRYLSYLAEIKFVAKPTGRGRPLPQMKADVLAALAVGGAGGRAAAPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCB0</accession>
    <name>G0SCB0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trehalase</fullName>
            <ecNumber evidence="4">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0056580</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="4"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695981.1">
        <property type="nucleotide sequence ID" value="XM_006695918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCB0"/>
    <dbReference type="STRING" id="759272.G0SCB0"/>
    <dbReference type="GeneID" id="18259696"/>
    <dbReference type="KEGG" id="cthr:CTHT_0056580"/>
    <dbReference type="eggNOG" id="KOG0602">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006451_4_0_1"/>
    <dbReference type="OMA" id="RYWDASD"/>
    <dbReference type="OrthoDB" id="3542292at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF1">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00928">
        <property type="entry name" value="TREHALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409448" description="Trehalase" evidence="5">
        <location>
            <begin position="22"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS19036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="709" mass="79892" checksum="67BB05DAF5FC0758" modified="2011-10-19" version="1">MMRRLSLRTTLSLVVLPLAAAIYINGSVIAPCDSPLYCYGEVLKAIELARPFVDSKTFVDMPTIKPLEEVLAAFQSLPHPLSNSSELQAFLAEYFAPAGGELEEVPRSELTTEPTFLTKVSDPVIREFTGKVIDIWPDLTRRYAGPGAGNCSTCANSFIPVNRTFVVAGGRFREPYYWDSYWIIEGLLRTGGSFVQIARNIIENFLDLVETIGFVPNGARVYYLNRSQPPLLTLMVKTYVDYTNDTSLLDRAVPLLLREYTFWTTNRSVEVPAPNGKTYTLHRYAVNNNQPRPESFREDWITANNESYYANSGIIYPVHKPLTDVEKATLYANLASGAESGWDYSSRWLRTPSDAARDVYFPLRSLNVRELVPVDLNSILYQNEIILSEFLHQTGNATGAEHFASLARARSEAMYTLMWNHTHWSYFDYNLTSSSQHIFSPVDDDTTPEEQQGVQSRKHQQVLFTPAQLYPFWTGAAPIHLKNNPLAVLNAFSRVTHLLNLNPGAVPASNYLSGQQWDEPNVWPPLQHILISALLSTPATFGPSDPSYLAVRQLALRLAQRYLDSTFCTWWATGGSTSETPRIEGLSEDKQGVMFEKYSDDKTSVAGGGGEYEVVEGFGWTNGVLIWVVERFGTGFMGELELKRPVCDFQWDEWGGKRPEGRRKRHAALGEKGRIAKGREPRSAVELDKWDAKWVKKFGRGRKVRSNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCL8</accession>
    <name>G0SCL8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-hexosaminidase</fullName>
            <ecNumber evidence="7">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0057690</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="7"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696089.1">
        <property type="nucleotide sequence ID" value="XM_006696026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCL8"/>
    <dbReference type="STRING" id="759272.G0SCL8"/>
    <dbReference type="GeneID" id="18259807"/>
    <dbReference type="KEGG" id="cthr:CTHT_0057690"/>
    <dbReference type="eggNOG" id="KOG2499">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007082_0_2_1"/>
    <dbReference type="OMA" id="GHDVVMC"/>
    <dbReference type="OrthoDB" id="428480at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016231">
        <property type="term" value="F:beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06562">
        <property type="entry name" value="GH20_HexA_HexB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000063">
        <property type="entry name" value="Beta-hexosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029019">
        <property type="entry name" value="HEX_eukaryotic_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF58">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14845">
        <property type="entry name" value="Glycohydro_20b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001093">
        <property type="entry name" value="B-hxosamndse_ab_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409126" description="Beta-hexosaminidase" evidence="9">
        <location>
            <begin position="22"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-hexosaminidase eukaryotic type N-terminal" evidence="11">
        <location>
            <begin position="22"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="10">
        <location>
            <begin position="190"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001093-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS19144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="582" mass="66516" checksum="245FFD0A4370CFEF" modified="2011-10-19" version="1">MRSLLLSSLCALLIALQPVVAVWPIPKKFKTGNTTLFLHQNLEIKYNDNLTQYTFGYEAATFDSHDIVRAGVSRALSTLFGEQFVPWMLHKPGDKFEPDVNGNLKWIKMLEITQTGKDDSEKILKPKAGEVDESYNLTLSADGEVKLTAVSSIGVLRGLETFIQLFYQHSAGTFWYTPYAPVEIEDEPKFDHRGLLIDTSRHFFPVDHILRTIDALAWNKMNRLHFHVTDSQSWPLEIPSMPELHKKGAHHPAFTYSPTDVDRIFKYGAMRGVQVYFEIDMPGHIGSVALSHPELITAWNARPYDAYCAQPPCGNFKLNSTKVDEFVKRLFDDLFPRISKYTSYFHTGGDEIKYKAYTLDDTVKSDKEDVLKPLLQKFFDKSHKQVRDAKLTPIVWEESVEKYNLALEKDVIVQTWTGDGKVQNVTSKGYGVIDSNVNYWYLDCGRGQWVLFDNNEYARGWPFNDWCGPTKSWQRIYSHDPRANLTAEQAKLVLGGEVAAWSETIDPLNFDPLVWPRASAAGEALWSGNKLESGQNRSQLEVAPRLFEWRERMVARGIRAAPLTQLFCTQRSPEECLWENPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCT5</accession>
    <name>G0SCT5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Methyltransferase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0058360</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-methionyl-[protein] + S-adenosyl-L-methionine = S-methyl-L-methionyl-[protein] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:60560"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:15592"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:142742"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:60561"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696156.1">
        <property type="nucleotide sequence ID" value="XM_006696093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCT5"/>
    <dbReference type="STRING" id="759272.G0SCT5"/>
    <dbReference type="GeneID" id="18259874"/>
    <dbReference type="KEGG" id="cthr:CTHT_0058360"/>
    <dbReference type="eggNOG" id="ENOG502QQMC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_2_0_1"/>
    <dbReference type="OMA" id="CDFYAPF"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF30">
        <property type="entry name" value="PROTEIN-METHIONINE METHYLTRANSFERASE LAEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS19211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="34933" checksum="031AD757628E6E7D" modified="2011-10-19" version="1">MDFRQYNGQNGDQQDQKLYEEVFQENGRWYGTFKKGSYLFPIDEKECERLDVFHKIFLVARGEELHKAPIPPDAPKVLDLGCGTGIWSINMADKYPGGTHLGLDLSYIQPEYIPHNLRFMQRDVEAPWEGLEPGSWDLIHARTLNGSIGNWPRVYAEVYRHLKRGGYFEQVEIDFYPRCDDGTLPRNAFITQWANELFDAMDYFGRPLRMDSNLTKQWLVQAGFSEIKEEVIKLPLNGWPTDNNGRELGRWFNLGMCQAFQPLSLAPLYRSNRRSVADIYDMAEKARAEVFSTQVHAYCNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCW5</accession>
    <name>G0SCW5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine diphosphorylase</fullName>
            <ecNumber evidence="3">2.7.7.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0058610</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-glucosamine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="3"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696181.1">
        <property type="nucleotide sequence ID" value="XM_006696118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCW5"/>
    <dbReference type="STRING" id="759272.G0SCW5"/>
    <dbReference type="GeneID" id="18259899"/>
    <dbReference type="KEGG" id="cthr:CTHT_0058610"/>
    <dbReference type="eggNOG" id="KOG2388">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025603_1_1_1"/>
    <dbReference type="OMA" id="YFQVDNP"/>
    <dbReference type="OrthoDB" id="532420at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04193">
        <property type="entry name" value="UDPGlcNAc_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000075">
        <property type="entry name" value="Probable UDP-N-acetylglucosamine pyrophosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039741">
        <property type="entry name" value="UDP-sugar_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952:SF2">
        <property type="entry name" value="LD24639P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952">
        <property type="entry name" value="UDP- GLUCOSE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS19236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="486" mass="53146" checksum="D79F74DD58E3F0AD" modified="2011-10-19" version="1">MAITTPQEPTPEQFQELKNKYTAANQGHVFNFWDSLSSEEKASLYQQLTLFDPEYINTIAAKALAPPKADAVPPSLEPLPDSARASILDSKKDEIDRWYSAGLDLIAANKVAVVLMAGGQGTRLGSSAPKGCFDIGLPSKKSLFQIQAERIRKVEELAAKKAGANVTVPWYVMTSGPTRGPTETFFKEHHYFGLKPENVFIFEQGVLPCISNDGKILLESKSKVAVAPDGNGGIYLALVQSGVLADMKKRGIEHVHAYCVDNCLVKVADPVFIGFSAEANVDIATKVVRKRNAAESVGLIVSKNGKPDVVEYSEIDPAIAAEEEPNQPGVLKFRAANIVNHYYSIRFLETIPQWAKTLPHHIARKKIPYADAETGETIKPNKPNGIKLEQFVFDVFPMLDMSKFACLEVRREDEFSPLKNARGTGEDDPDTSRRDIMAQGRRWIEAAGAKVEGNEGVEVSPLLSYGGEGLEQFAGKTIPADSQLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCX0</accession>
    <name>G0SCX0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase PFA4</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Protein S-acyltransferase</fullName>
            <shortName evidence="11">PAT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Protein fatty acyltransferase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PFA4</name>
        <name evidence="14" type="ORF">CTHT_0058660</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11 12">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11 12">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DHHC palmitoyltransferase family. PFA4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696186.1">
        <property type="nucleotide sequence ID" value="XM_006696123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCX0"/>
    <dbReference type="STRING" id="759272.G0SCX0"/>
    <dbReference type="GeneID" id="18259904"/>
    <dbReference type="KEGG" id="cthr:CTHT_0058660"/>
    <dbReference type="eggNOG" id="KOG1314">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027721_8_1_1"/>
    <dbReference type="OMA" id="WEIERHK"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03199">
        <property type="entry name" value="DHHC_PAT_PFA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033682">
        <property type="entry name" value="PFA4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0564">Palmitate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="13">
        <location>
            <begin position="108"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="active site" description="S-palmitoyl cysteine intermediate" evidence="11">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS19241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="462" mass="52665" checksum="ED2AD2DD232597BA" modified="2011-10-19" version="1">MTSPITGPLAPGLHRLYIPAVCLLISFQGYYSQYLFNTEPDLAPGPLTRRETITFNTLLLCLWYTYYRACTVDPGRYIFSPSSEFSSSTGADPDLRPTSSLLSSQRRPRRFCKKCSAPKPLRAHHCRHCGRCIPKMDHHCPWTGNCVSMQTFPYFLRFLVYTNVSLWYLARLLWQRVAGIWASRKLPAYLGPSVHGLVGVTVLGLANMGTMVALGILLITTVKAWVWNCTMIEEWEVERHEAVLARLGGDDEQGEEDPFWGDDTAALRARLEKIEFPYDLGVWKNMSQAMGTRNVLRWFLPFGGGGPVVDNSNPGKGAGWEWEENGFNDLPGMWPPPDPEKMRREARGGWPAAVASQQQPRTLLDQCQTAEEIKEAFRRRQEEDLRRRQKYQALERKGIIEELEEVPGKTSGEGEWIGEPAWTNSEGERLWDYGVDEGADEEDMPLAELMRRRKVSTHRKYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>G0SD06</accession>
    <name>G0SD06_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0050330</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695381.1">
        <property type="nucleotide sequence ID" value="XM_006695318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SD06"/>
    <dbReference type="GeneID" id="18259071"/>
    <dbReference type="KEGG" id="cthr:CTHT_0050330"/>
    <dbReference type="HOGENOM" id="CLU_1686364_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="156" mass="16718" checksum="39DE357C77763487" modified="2011-10-19" version="1">MASYLNGLVWNTNNPIELNDNDAVRTNRLEVPAAGKYRHFVFEDCQSVIFYKEKAPDSQPDLIVQKPSNNPTGNIVVPPGVRLIVNGGRMREIPISAGTSAPPPSSVSGYEGNYSLSGSSGKYTPAVHAQDNASTVSQSTVYPHDSASNVGVYNHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G0SD09</accession>
    <name>G0SD09_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Fructose-bisphosphate aldolase</fullName>
            <shortName evidence="12">FBP aldolase</shortName>
            <ecNumber evidence="4 12">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0050360</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11 12">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="4 12"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695384.1">
        <property type="nucleotide sequence ID" value="XM_006695321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SD09"/>
    <dbReference type="STRING" id="759272.G0SD09"/>
    <dbReference type="GeneID" id="18259074"/>
    <dbReference type="KEGG" id="cthr:CTHT_0050360"/>
    <dbReference type="eggNOG" id="KOG4153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036923_1_0_1"/>
    <dbReference type="OMA" id="PRTWGKL"/>
    <dbReference type="OrthoDB" id="35652at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00946">
        <property type="entry name" value="FBP_aldolase_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006411">
        <property type="entry name" value="Fruct_bisP_bact"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01520">
        <property type="entry name" value="FruBisAldo_II_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006628">
        <property type="entry name" value="PRK09197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559:SF0">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE CLASS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00602">
        <property type="entry name" value="ALDOLASE_CLASS_II_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00806">
        <property type="entry name" value="ALDOLASE_CLASS_II_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 12" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="249"/>
            <end position="251"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="265"/>
            <end position="268"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS18439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="337" mass="37019" checksum="5736AB2998E5A621" modified="2011-10-19" version="1">MGILEDLNLPAGVIYGDDVLKLFTYAREKGFAIPACNVTSSSTVVAALEAARDAKAPIILQTSQGGAAYFAGKGIKNSAEKQEASVAGAIAAAHYIRSIAPLYGIPVVLHTDHCAKKLLPWLDGMLDEDERFFKQNGIPLFSSHMIDLEPVDENIETCVKYLKRMAPMKQWLEMEIGITGGEEDGVDNTGVDNAALYTQPEDIWKINVHGVYAPGNVRLHPELLSKHQAYVAEKLGTDNKKPVFFVFHGGSGSSKEEYLEAISVNVDTDLQWAYLCGVRDYILKNIEYLKTQVGNPEGPNKPNKKKYDPRVWVREGEKTMSAKVGSLLQDFKTAGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDJ9</accession>
    <name>G0SDJ9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0052050</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695545.1">
        <property type="nucleotide sequence ID" value="XM_006695482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDJ9"/>
    <dbReference type="GeneID" id="18259243"/>
    <dbReference type="KEGG" id="cthr:CTHT_0052050"/>
    <dbReference type="eggNOG" id="ENOG502S60G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_432106_0_0_1"/>
    <dbReference type="OrthoDB" id="5388486at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039970">
        <property type="entry name" value="TF_Grauzone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23225:SF2">
        <property type="entry name" value="AT09679P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23225">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="633" mass="70265" checksum="80FAA677A998222A" modified="2011-10-19" version="1">MATVYPNPIMGGFPLYEHGHFSQTESPFEFVDPVDPALKDFAPQMTSVSYGTTTYAWAPLPSYVRKDDQPWSMYHATISMQPLPSCSLPSMATVPSPSSAAAISPRQSPSLLSHGDTESRHDSFPRTPDLTSSPATLSLDTPSDMQPLQHAGTGVGVPDYVNPQDVNYQQDYPVAEHDAFSRSSTSTNGIDYYAGSDDEPGNTTYPNYTYSSVGVTTSMVSNINAVTSGPECHLSSTSRCQSPVTDTIYDVRSKRHHDSDNDNEQTNREDRPLKRSKTAPCYHLSTSSTPVYRTAASIGRRRQRDSHMVSTANLFSTDGEEHKRHIFPCVFRFAGCDGVFKAKNEWKRHVSSMHLLERYWICYDSETPSSSQSQSQKSHAHQQHESFFNRKDLFTQHLRRMHCPAALKPYLDNATSISAICSLASSRCKTNNKTMGKTKSSKRGSQTLPNLPPHLRPLMEEWIAYVQERWERCQRVRKLPSTFRCPVPGCCSEPNGKNSPGSTEIGTPTIFHDTPKNTAWNQRMEHIAKHLMRFAQLEDEGASAEEKAKERVEFGGTGDEELVAWASSPEVGIIRRNAKGEWELTEAFKKGPGNTGSCGAMEIPGTGGEMMKEEIVVVGGYEEEGDAEGEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDT3</accession>
    <name>G0SDT3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protection of telomeres protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0052910</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the telombin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695629.1">
        <property type="nucleotide sequence ID" value="XM_006695566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDT3"/>
    <dbReference type="STRING" id="759272.G0SDT3"/>
    <dbReference type="GeneID" id="18259329"/>
    <dbReference type="KEGG" id="cthr:CTHT_0052910"/>
    <dbReference type="eggNOG" id="KOG4757">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016663_0_0_1"/>
    <dbReference type="OMA" id="WEPHASF"/>
    <dbReference type="OrthoDB" id="2186770at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000783">
        <property type="term" value="C:nuclear telomere cap complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098505">
        <property type="term" value="F:G-rich strand telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010521">
        <property type="term" value="F:telomerase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032210">
        <property type="term" value="P:regulation of telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016233">
        <property type="term" value="P:telomere capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000303">
        <property type="entry name" value="Protection of telomeres protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028389">
        <property type="entry name" value="POT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032042">
        <property type="entry name" value="POT1PC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011564">
        <property type="entry name" value="Telomer_end-bd_POT1/Cdc13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14513">
        <property type="entry name" value="PROTECTION OF TELOMERES 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14513:SF0">
        <property type="entry name" value="PROTECTION OF TELOMERES PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02765">
        <property type="entry name" value="POT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16686">
        <property type="entry name" value="POT1PC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00976">
        <property type="entry name" value="Telo_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Telomeric single stranded DNA binding POT1/Cdc13" evidence="11">
        <location>
            <begin position="25"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="535"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="605"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="386"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="539"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="605"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS18684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="684" mass="78073" checksum="B63E4DDA94F971C2" modified="2011-10-19" version="1">MPNTTGLQRAHAPQYPAEPPLPQRVDTIRDLLDGKRPFGSLVCVVGLVKDQRLPKQTKGADWKSELTLYDLSIEYENDGIVFSIFRPQADMPMCNVGDIVFIIDAKLQHYNGRTSLITNQATIIQVYKACRIPEWPHPAEPALEPPTRRDKHSLTAEEHLYVSWMYHKIDKCLLPTEEEFQQRAAQSLNVKEKFTLLKDVHEGQFCDLIVEVVREPHAFLDMVTLYVSDYTENSAFHPQAWDMVPNLAGDPYGYLPASSQASKKEWYGPHGKMSLQITCYEPHASFITNHVSAKQWVYLRNVQIKYGRDGKYLEGFMREERNISASRVNVQLMDTTNRDTVDPRLKDAIRRKLEYGKKVKEDLRQIKAAQEAGLKRKASEASVGEKQELNSKLRRQLKRRIREQKEKGGKQNREQQLNLNQAVTCEKHDDVPDSTIESILEPTIYNPTVDQQPVGLLLPFVCAKYQAFVRVVDFWPPNLEDFACSRKVSEFDMISDYDGSDMDSSASCSKSEEDEAAESESRRIWEWRFFLQLEDPTPASDTSNSENSTNKPRPRLWALVDNAEAQCLTGLDACDLRKDTRALATLRERMFTLWGNLEEVKTQVQQGKEQAAKQKAAAARPRHQPPGAADKALNLERPPLDSSDDEREYGSTSGIVNEYFVQYLGHSAIHLYIKPLKQGKAKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDY3</accession>
    <name>G0SDY3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lipocalin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0053430</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695679.1">
        <property type="nucleotide sequence ID" value="XM_006695616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDY3"/>
    <dbReference type="GeneID" id="18259381"/>
    <dbReference type="KEGG" id="cthr:CTHT_0053430"/>
    <dbReference type="eggNOG" id="ENOG502S22D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088979_2_0_1"/>
    <dbReference type="OMA" id="WEMDSTH"/>
    <dbReference type="OrthoDB" id="425354at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053037">
        <property type="entry name" value="Pericyclase_pydY-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38115">
        <property type="entry name" value="LIPOCALIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38115:SF1">
        <property type="entry name" value="LIPOCALIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS18734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="24403" checksum="66EC93A4E541BEC7" modified="2011-10-19" version="1">MAAPADKHIGDLNGKWVMVCSPLQYQNPRYRPEAHTSQNKAQSDSVDPALQLQSVGWMTRKIIGLATLTLHVKQFVAPPSPPADPANPPVTHIEIEQTGTGGMKGTTEKRCLDYTFRDHSDWIFGHVKGQSRFIKTEEIDDEFLKKGWLEGEEEAKGPNGETHIISHVESYDNGWTATQIWGFKNINGERKYVRNVVVKKGAERVEIQLVYDYLGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDZ4</accession>
    <name>G0SDZ4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0053540</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family. PalF/RIM8 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695690.1">
        <property type="nucleotide sequence ID" value="XM_006695627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDZ4"/>
    <dbReference type="STRING" id="759272.G0SDZ4"/>
    <dbReference type="GeneID" id="18259392"/>
    <dbReference type="KEGG" id="cthr:CTHT_0053540"/>
    <dbReference type="eggNOG" id="ENOG502QTQN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006001_0_0_1"/>
    <dbReference type="OMA" id="CLHGYAK"/>
    <dbReference type="OrthoDB" id="7785529at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF161">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALF_RIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="3">
        <location>
            <begin position="318"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="216"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="538"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="818"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="561"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="586"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="608"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="629"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="655"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="668"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="708"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="742"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="818"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS18745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="843" mass="90951" checksum="62766DB2D626876A" modified="2011-10-19" version="1">MGISRNSSNSRTARSSPALSNASKKHTIFQVFTIPYKFIRFLRSRSGPVNEFYIRLVDPHRQYGSGDVVKGAVILTVVKPICITHLVVSLHGYVRIYKGTNAPTDIPPNPSEHAASSGYITLFHEEVPLSGEGRLEPGRYEFLFDLDIPQGSFPSSIEFEKGTISYVVTATLTLPTSDPNRLPRQHSCACHIQLVKMVDIGFIKAPLPQIISLEPISKRPKKKRPPDPSAESSTTINTAVPGSSSDMLRMSGHVTEAGYDHTHEPHGNNPQNATQSDVRSISDESAATSSTAHSRADVSSLHAPAIGSLGDRRNRSLKERTITATVELLKGGCLPGDTVPVKISVQHNRPIRSMRGVILTLYRLTRIDSSPLSFTRESTDHEGQRTPTEDFFPRFRTGLGVLSSFSSSNPYCLFRKDLAQAFAPLIINPESLKAELVTSVRVPVDAFPTIQDVPHEIISFTYHIEVLVDLGGKLANQIRGGLPSPPAVNTLGGPPGLSDSAATMTAYAANILETDGLRRQKGVISAAFDLVVGTLDSSRNRARNSTRPSPAVSAVPVGSTPRPSQAGVQPSASPHVEPYTPVNRPQAHTPSPIAQLSPQSYPYWNNIPPKPLPEPYPIPPPQLPDESALSEKERMRLAEQRLLPSQPPEVPLARLSHSSHLNPSPNSAYSSDSQPPFSLTFEAPSAPTLDDIAAGSTAQASAVPDGGTEDKQELERRQLLAEVSAPPQFPPDGYGGDGQGATGSLSFSAQRQLEQPTAPPLSMVEGDDHKEPSAPPPELLGEDPQPRDDEALYGRGYSYGEYTSSYLAACLPYQQLSGVQAQGHISSSGQHNGGNEPLPKYEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0SE02</accession>
    <name>G0SE02_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative 1,3-beta-glucan protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0061940</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KNR4/SMI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696510.1">
        <property type="nucleotide sequence ID" value="XM_006696447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SE02"/>
    <dbReference type="STRING" id="759272.G0SE02"/>
    <dbReference type="GeneID" id="18260232"/>
    <dbReference type="KEGG" id="cthr:CTHT_0061940"/>
    <dbReference type="eggNOG" id="ENOG502QTAZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024700_0_0_1"/>
    <dbReference type="OMA" id="ESLMVHD"/>
    <dbReference type="OrthoDB" id="2305498at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070880">
        <property type="term" value="P:fungal-type cell wall beta-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1580.10">
        <property type="entry name" value="SMI1/KNR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009203">
        <property type="entry name" value="Knr4/Smi1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051873">
        <property type="entry name" value="KNR4/SMI1_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47432">
        <property type="entry name" value="CELL WALL ASSEMBLY REGULATOR SMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47432:SF1">
        <property type="entry name" value="CELL WALL ASSEMBLY REGULATOR SMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09346">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017023">
        <property type="entry name" value="KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00860">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SMI1/KNR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Knr4/Smi1-like" evidence="3">
        <location>
            <begin position="142"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="383"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="222"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="473"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS18179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="529" mass="57257" checksum="A289E347BC76C34E" modified="2011-10-19" version="1">MASLLRSFWHVMTSNDRHSDYNSPIRTGRHVPLGARNPLTSIATAGESRSDITSPYHDDAHHPGFDPNGATSPRNSIPYSPGMRSQAAANDAFEIASPTGSIPMQSFQDGMPPPPPVSASWKKIDAWAEENYPELFDQLCEGCTINDLNELEYQLDCSLPQDVRESLQIHDGQERGGTPTGIIFGHMLLDCEEIVQEWENWRKVNQDILMTEPPFNRPPPATASSSKSAAAGSSQASTSAAASSSSAPTSPRRTNWREELLARQNCVPPGTIQKAYAHPAWIPLVRDWGGNNLAVDLAPGPNGHWGQVILFGRDYDTKYVIARSWAAFLAIVADDLNSGRWFIDEDSGELKLREFKTTRVEPSYFDILRWRMDQKYGRTAAAAAKRRSMAPSITGVPGASSLSAPTSPYVTPADGHGEPQRGRSIQRLKSSISPIPSPIRPAGYGKSTPLAHITEEAGPSGSAEGTSSPVAAGKEKLVEVDTPRQSGEEKKKDAAAEGQQKEEEEGKAEASSSSKAAEAEGDGMKTIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0SE59</accession>
    <name>G0SE59_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Glutamine synthetase</fullName>
            <ecNumber evidence="3 11">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0062540</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>L-glutamate + NH4(+) + ATP = L-glutamine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9 10">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="3 11"/>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696567.1">
        <property type="nucleotide sequence ID" value="XM_006696504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SE59"/>
    <dbReference type="STRING" id="759272.G0SE59"/>
    <dbReference type="GeneID" id="18260292"/>
    <dbReference type="KEGG" id="cthr:CTHT_0062540"/>
    <dbReference type="eggNOG" id="KOG0683">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036762_1_1_1"/>
    <dbReference type="OMA" id="TKDYADH"/>
    <dbReference type="OrthoDB" id="1936100at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000004">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050292">
        <property type="entry name" value="Glutamine_Synthetase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852:SF57">
        <property type="entry name" value="GLUTAMINE SYNTHETASE 2 CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51986">
        <property type="entry name" value="GS_BETA_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS beta-grasp" evidence="12">
        <location>
            <begin position="26"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="GS catalytic" evidence="13">
        <location>
            <begin position="114"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS18236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="363" mass="40645" checksum="522FB898B7061B6A" modified="2011-10-19" version="1">MAHEPSFVTYTENLQKFMRLPQRGNIIAEYIWVDSEGGVRSKARTLPEKETPYTPDELPMWNFDGSSTGQAPGDNSDVYLKPVAVFPDPFRGTPNILVLAECWNNDGTPNKYNHRHECAKLMAAHAEQKPWFGLEQEYTLLDLNDRPYGWPRNGFPAPQGPYYCGVGAGKVVQRDIVEAHYKCCLYAGVKISGINAEVMPAQWEFQVGPCEGIEMGDHLWIARYLLHRVAEEFGAKVSFDPKPIPGDWNGAGLHTNFSTKDMREEGGMKHIEAAIKKLEARHAEHIAVYGEGNEKRLTGRHETGKIDTFTYGVANRGASIRIPREVAAKGYGYFEDRRPASNADPYQITGIIMETCFGAVSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFD8</accession>
    <name>G0SFD8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nuclease-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0061690</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPG/RAD2 endonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696485.1">
        <property type="nucleotide sequence ID" value="XM_006696422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFD8"/>
    <dbReference type="STRING" id="759272.G0SFD8"/>
    <dbReference type="GeneID" id="18260207"/>
    <dbReference type="KEGG" id="cthr:CTHT_0061690"/>
    <dbReference type="eggNOG" id="ENOG502QVHA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_378548_0_0_1"/>
    <dbReference type="OMA" id="RFYQTKV"/>
    <dbReference type="OrthoDB" id="17262at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09902">
        <property type="entry name" value="H3TH_MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09858">
        <property type="entry name" value="PIN_MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022039">
        <property type="entry name" value="MKT1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037314">
        <property type="entry name" value="MKT1_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022040">
        <property type="entry name" value="MKT1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF32">
        <property type="entry name" value="POST-TRANSCRIPTIONAL REGULATOR MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12246">
        <property type="entry name" value="MKT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12247">
        <property type="entry name" value="MKT1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Post-transcriptional regulator MKT1 N-terminal" evidence="4">
        <location>
            <begin position="317"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Post-transcriptional regulator MKT1 C-terminal" evidence="3">
        <location>
            <begin position="489"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS18154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="733" mass="82835" checksum="F31D242739AA13E6" modified="2011-10-19" version="1">MMPPPNLTEDPFINQVLTYPLSDLEDCAIAIDATYWLQLHLDVLPGNEPLLPALGGLTGIQARIENELDQWKLNKMTPFFIFDGQAIVGQDEVAVRRGLDLNLKTDGAWELYFNSRADEAVHAFGQTISAFPTRALYPLLQSILRQRGLHFLVPPFNAAAQMAYFEMIDSDQCAGIMGSTELLLYPIRDCIIRMIDWDNKMVYAISKKNILKTLNVSESLFIDAFLMTGTSFLPPFPPLADQTIIKASRYTVVDACTMLRTTEKSVTIACTSFNDILKAHDPNWLEKYRKARMAVDHFIYIAENGEVKVNDYDHLTKDNHEYLGLQLPAELFHYLNTGLIGPRVLTWITHGQLQVLPTLDGVASEEYKKLVTSQSVRIKEAALSLVIPRLNRGIGYKNITMKVWYDRNYSYTVWDRHEPKTSYAPQVSSWSVKEESFSAHFPQFSHGSILSEVLALQKPEFVPLTRSSPSSKLKSVESAAVIKSITLWRFLHIRGYVDDHHELTGWGKALAAALAAIKPTVEKFPDFPNLYESILVAFELIRFDLLNAKNKHEELRGLPLNGSEEDQSSLLLISRCATLLKLRHEANGYTGPLSKNLLHFRTLVSEVRSADRDLIEAILASMFMYAQAKRKRDDGWELSHQLPFLYDPDVALGIAVKTYFDDILPNDPNKAQKKAAFPGTYVPYALNFAEDLDIACSFFDAVYAGIQTLDAKDLPVADRAVWDKAAKYLELRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFF2</accession>
    <name>G0SFF2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CTHT_0061830</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. COT1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696499.1">
        <property type="nucleotide sequence ID" value="XM_006696436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFF2"/>
    <dbReference type="STRING" id="759272.G0SFF2"/>
    <dbReference type="GeneID" id="18260221"/>
    <dbReference type="KEGG" id="cthr:CTHT_0061830"/>
    <dbReference type="eggNOG" id="KOG0605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_67_5_1"/>
    <dbReference type="OMA" id="MLVHHAL"/>
    <dbReference type="OrthoDB" id="3638488at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000192">
        <property type="entry name" value="Serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF76">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_135, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="96"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="15">
        <location>
            <begin position="404"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="423"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="444"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGS18168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="488" mass="56067" checksum="9A1797DA78F0A286" modified="2011-10-19" version="1">MIMDNFEFAPAPPQRCPEAYGPRANNNQKRCFQLAQAFFKDGVRRARERNERQLDLERRLEDPAVGPRREQLWKLGGMSEAKYLRFLRTKEELSNYIPIKTIGKGYFGEVKLVRKKQDGKVYALKRLAKTEMVSHEQLPRVRAERDALAESDSEWVVKLYTTFQDSTSLYLLMEYLPGGDLMALLIKYQIFSEDITRFYAAEMIMAIEAIHNLGFIHRDIKPDNILIDREGHVKLADFGLSKGFSKSHDHSYYRELLQKPAPPNNKPANRNSVNLDEIALTVSNRAQINEWRRSRRLMAYSAVGTPDYIAPELFTGQGYSFEIDWWSLGAIIYECLVGWPPFASDNSYDTYRKIVNWRQTFFFPDDVYLHPNAAHLIRSLICDASSRLGSRGGAAEIKAHPFFAGVDFNSLRRIEAPFRPHLESDEDTSCFPVDELPQGEGFSNGPTNTNGTNGHQATASNFQEEEVTPEMCLPFIGYTFKRFEKTFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFU3</accession>
    <name>G0SFU3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0072150</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697476.1">
        <property type="nucleotide sequence ID" value="XM_006697413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFU3"/>
    <dbReference type="STRING" id="759272.G0SFU3"/>
    <dbReference type="GeneID" id="18261253"/>
    <dbReference type="KEGG" id="cthr:CTHT_0072150"/>
    <dbReference type="eggNOG" id="KOG0800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050242_0_1_1"/>
    <dbReference type="OMA" id="RRHIYRH"/>
    <dbReference type="OrthoDB" id="444265at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46077">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TOPORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46077:SF1">
        <property type="entry name" value="TOP1 BINDING ARGININE_SERINE RICH PROTEIN, E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="32"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="293"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="294"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS17858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="322" mass="37683" checksum="270D6B426B51DEC2" modified="2011-10-19" version="1">MSDNDVERAHILQATLRQISVFAAEGAERECCVICLGDLTEPCEARPCGHTNFDFVCLATWLEARTTCPLCKCDVIELGYDLAEDGQYRKVYAIPQRAPPKDQQPVVRRAEVTVRHRVQEHLRRRRPRSPASREDDAIRRRRMVYRYGLYSLHVGSNRRQPPGMRYTELSLQRFATESELISRARMFIRRELRVFRFLYTNDDEDLRGVEDVVRVQRPCRAEFLLEYIVAILKAMDTQGSAGQAEELVSEFLGRDNARLFLHELRAWLRSPCKTLEEWDRLVQYNDPRVMYRPLQDRQRARNEAPRSDRPTPVQMANPMDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0SG43</accession>
    <name>G0SG43_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0064970</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696800.1">
        <property type="nucleotide sequence ID" value="XM_006696737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SG43"/>
    <dbReference type="STRING" id="759272.G0SG43"/>
    <dbReference type="GeneID" id="18260535"/>
    <dbReference type="KEGG" id="cthr:CTHT_0064970"/>
    <dbReference type="eggNOG" id="ENOG502RJF6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069686_0_0_1"/>
    <dbReference type="OMA" id="WAQWYPA"/>
    <dbReference type="OrthoDB" id="2862635at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070007">
        <property type="term" value="F:glutamic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13426">
        <property type="entry name" value="Peptidase_G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.700">
        <property type="entry name" value="Peptidase G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000250">
        <property type="entry name" value="Peptidase_G1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038656">
        <property type="entry name" value="Peptidase_G1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536:SF1">
        <property type="entry name" value="ASPERGILLOPEPSIN, PUTAITVE (AFU_ORTHOLOGUE AFUA_7G01200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01828">
        <property type="entry name" value="Peptidase_A4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409483" evidence="3">
        <location>
            <begin position="21"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS17182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="330" mass="35096" checksum="6AACD5AC183B7111" modified="2011-10-19" version="1">MKRTTFLTTCFLSVVYSATALPIRQICQRSSDQPRLLHTFSSYPILSSTGNPQLHSSSQQPPESTTGGATLTLPPLSSNNTNSTSSRSLSLRTTFRIPHAFPPTTGPTAGNTVGLYAASFWIGLDSLTHPDCLAAVRAGVDIFWDGTLGGELAPFVWCQFGRGQAGGMPGFKAAAGDVVRFWVDAGVGGFAVVGVENWGPEGREDEGQDGDEVGKREVKRPISAVKKVFKMEEGVGRRQSEESGQSACGLEVAWIVEDFPLVGGPGVPVALANFTSISFEQIGVARGSESWDATGAEVRDVWLNAQGGRLTRCKVVEGSEVKCLRVVGDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGA4</accession>
    <name>G0SGA4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mannosyltransferase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0065620</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696861.1">
        <property type="nucleotide sequence ID" value="XM_006696798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGA4"/>
    <dbReference type="GeneID" id="18260600"/>
    <dbReference type="KEGG" id="cthr:CTHT_0065620"/>
    <dbReference type="eggNOG" id="KOG4472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024327_4_3_1"/>
    <dbReference type="OMA" id="WCFFLYQ"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF7">
        <property type="entry name" value="MANNOSYLTRANSFERASE KTR4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS17243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="46755" checksum="8AD4DA62F29CCFD8" modified="2011-10-19" version="1">MAIARPARALSLAAIVLWFFFLWQIFHPPRPTDQWAKWRMEHDPNLDPTGEPEGILTRAGPGYEPGPKGTARINATLLALVRNEELEGMLQAMRDLERTWNRKFNYPWTFFNDVPFTEEFMRKTQAETNAECRYEVIPKEHWEMPSWINRELFKESTKLLKEQGVQYADMVSYHQMCRWNSGMFYKHPALEHVQYYWRVEPKVHFFCDIDYDVFRYMRDNNKTYGFTINLYDSPESIPTLWPETLKFLADHPDYIHPNNAMDWLTDKVRRPDHNEKANGYSTCHFWSNFEIADMNFWRSKAYEDYFNHLDRAGGFFYERWGDAPVHSIALGLFEDKNKIHWFRDIGYQHIPFFNCPNSPKCKGCKTGLLTDGEPFLYMEDCRPNWFKYVGMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2023-02-22" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGF0</accession>
    <name>G0SGF0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0066090</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696907.1">
        <property type="nucleotide sequence ID" value="XM_006696844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGF0"/>
    <dbReference type="GeneID" id="18260647"/>
    <dbReference type="KEGG" id="cthr:CTHT_0066090"/>
    <dbReference type="HOGENOM" id="CLU_1209699_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="229" mass="25913" checksum="FEEC5B071085BEB6" modified="2011-10-19" version="1">MWQTTALWKSCETDKDFARYSMVIQAKTPSTILMGSVESFGRSGGSTLIKSAVGGDDDQPNAPNPKDPEVMRSQLEVITNGKPDLKGFFEQASSDVVQKHEDSIQEIRQDAEQAKAGKTDKSAWRTKLREKRDKLVENSKEWILSAFAKAESMIDTLPEPIQEQAGNWFNDLMDSLTNWLSDAIQKISQFVHDALEFIKVVWNKTVELAKEAAEKIAEAWEYVKEIFHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGJ6</accession>
    <name>G0SGJ6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0066560</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696953.1">
        <property type="nucleotide sequence ID" value="XM_006696890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGJ6"/>
    <dbReference type="STRING" id="759272.G0SGJ6"/>
    <dbReference type="GeneID" id="18260694"/>
    <dbReference type="KEGG" id="cthr:CTHT_0066560"/>
    <dbReference type="eggNOG" id="ENOG502T6E8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062877_0_0_1"/>
    <dbReference type="OrthoDB" id="3836772at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409544" evidence="1">
        <location>
            <begin position="20"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="322" mass="36042" checksum="81CF5925390DCACD" modified="2011-10-19" version="1">MRFILSLLFHVVHLPFTTAEVLGEWTLRSLTRTCDADGKSCQYSLDISIEYFPNTTDPNAETKVGSECGFSVKAGAFPEDNPPNLLANETSFKAVDCWESRLVEQPSQPDSQPRFVVNGGYDRVGNFWTIVPTDRKRDAYAFFGYPEEELESGVTAKEAKKAKALKVGTFERGVEVWGFEGKIKRDNDNVNEGEHAIKVMALDVQEWKKVEGRMWQVKGLTRFPDLSLNATDISFSIIDNVGAETHCSLAIRGTDPRESWYGKACGRDFTISWGYNGRADSAVMTVCYPRNGTSAWFGFDHVNKALYLGNSRKEPVYYSGCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGM0</accession>
    <name>G0SGM0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">H/ACA ribonucleoprotein complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nucleolar protein family A member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0066810</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2017" name="Nat. Struct. Mol. Biol." volume="24" first="954" last="964">
            <title>3.2-A-resolution structure of the 90S preribosome before A1 pre-rRNA cleavage.</title>
            <authorList>
                <person name="Cheng J."/>
                <person name="Kellner N."/>
                <person name="Berninghausen O."/>
                <person name="Hurt E."/>
                <person name="Beckmann R."/>
            </authorList>
            <dbReference type="PubMed" id="28967883"/>
            <dbReference type="DOI" id="10.1038/nsmb.3476"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.20 ANGSTROMS)</scope>
    </reference>
    <reference evidence="15 16 17" key="3">
        <citation type="journal article" date="2019" name="Mol. Cell" volume="75" first="1256" last="1269.e7">
            <title>Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration.</title>
            <authorList>
                <person name="Cheng J."/>
                <person name="Bassler J."/>
                <person name="Fischer P."/>
                <person name="Lau B."/>
                <person name="Kellner N."/>
                <person name="Kunze R."/>
                <person name="Griesel S."/>
                <person name="Kallas M."/>
                <person name="Berninghausen O."/>
                <person name="Strauss D."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="31378463"/>
            <dbReference type="DOI" id="10.1016/j.molcel.2019.06.032"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.50 ANGSTROMS)</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Common component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA. In association with box C/D snoRNPs, required for processing of pre-ribosomal RNA (rRNA) and site-specific 2'-O-methylation of substrate RNAs. Essential for the accumulation and stability of U4 snRNA, U6 snRNA, and box C/D snoRNAs.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696977.1">
        <property type="nucleotide sequence ID" value="XM_006696914.1"/>
    </dbReference>
    <dbReference type="PDB" id="5OQL">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="V/W=1-127"/>
    </dbReference>
    <dbReference type="PDB" id="6RXT">
        <property type="method" value="EM"/>
        <property type="resolution" value="7.00 A"/>
        <property type="chains" value="CE/CF=1-127"/>
    </dbReference>
    <dbReference type="PDB" id="6RXU">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.50 A"/>
        <property type="chains" value="CE/CF=1-127"/>
    </dbReference>
    <dbReference type="PDB" id="6RXV">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.00 A"/>
        <property type="chains" value="CE/CF=1-127"/>
    </dbReference>
    <dbReference type="PDB" id="6RXX">
        <property type="method" value="EM"/>
        <property type="resolution" value="7.10 A"/>
        <property type="chains" value="CE/CF=1-127"/>
    </dbReference>
    <dbReference type="PDB" id="6RXY">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.70 A"/>
        <property type="chains" value="CE/CF=1-127"/>
    </dbReference>
    <dbReference type="PDB" id="6RXZ">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.40 A"/>
        <property type="chains" value="CE/CF=1-127"/>
    </dbReference>
    <dbReference type="PDBsum" id="5OQL"/>
    <dbReference type="PDBsum" id="6RXT"/>
    <dbReference type="PDBsum" id="6RXU"/>
    <dbReference type="PDBsum" id="6RXV"/>
    <dbReference type="PDBsum" id="6RXX"/>
    <dbReference type="PDBsum" id="6RXY"/>
    <dbReference type="PDBsum" id="6RXZ"/>
    <dbReference type="AlphaFoldDB" id="G0SGM0"/>
    <dbReference type="EMDB" id="EMD-10051"/>
    <dbReference type="EMDB" id="EMD-10052"/>
    <dbReference type="EMDB" id="EMD-10053"/>
    <dbReference type="EMDB" id="EMD-10054"/>
    <dbReference type="EMDB" id="EMD-10055"/>
    <dbReference type="EMDB" id="EMD-10056"/>
    <dbReference type="EMDB" id="EMD-3847"/>
    <dbReference type="SMR" id="G0SGM0"/>
    <dbReference type="IntAct" id="G0SGM0">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0SGM0"/>
    <dbReference type="GeneID" id="18260719"/>
    <dbReference type="KEGG" id="cthr:CTHT_0066810"/>
    <dbReference type="eggNOG" id="KOG3387">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084513_4_1_1"/>
    <dbReference type="OMA" id="IKNQIYA"/>
    <dbReference type="OrthoDB" id="1924699at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000002">
        <property type="entry name" value="NHP2-like protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002415">
        <property type="entry name" value="H/ACA_rnp_Nhp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00883">
        <property type="entry name" value="NUCLEARHMG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="14 15 16" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="11">
        <location>
            <begin position="22"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS17359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="5OQL"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="6RXT"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="6RXU"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PDB" id="6RXV"/>
        </source>
    </evidence>
    <sequence length="127" mass="13815" checksum="CC01F10CFCDDCBBF" modified="2011-10-19" version="1">MSNNESAAWPKAEDPALVQELLDCVQQASHYRQLKKGANETTKSVNRGTSELVILAADTQPLSIVLHIPLICEEKNVPYVYVPSKVALGRACGVSRAVIAVSLTSNEASDLNSKIRALRDKVERLAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGP7</accession>
    <name>G0SGP7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Something about silencing protein 4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0067110</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697004.1">
        <property type="nucleotide sequence ID" value="XM_006696941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGP7"/>
    <dbReference type="STRING" id="759272.G0SGP7"/>
    <dbReference type="GeneID" id="18260749"/>
    <dbReference type="KEGG" id="cthr:CTHT_0067110"/>
    <dbReference type="eggNOG" id="ENOG502RYH0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011914_1_0_1"/>
    <dbReference type="OMA" id="ELAMYFP"/>
    <dbReference type="OrthoDB" id="1938992at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033255">
        <property type="term" value="C:SAS acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038988">
        <property type="entry name" value="Sas4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029184">
        <property type="entry name" value="Sas4_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38422">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38422:SF1">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15460">
        <property type="entry name" value="SAS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Something about silencing protein 4" evidence="2">
        <location>
            <begin position="259"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="476"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="510"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="571"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="658" mass="72785" checksum="A873100625BEE149" modified="2011-10-19" version="1">MAMATAAAAATRSRRAERRAKEPAAPSQQQQQPVQQQQQQQQQLARAKRARDFTDHGDRDTVVAKKPRLGIAVEFPTKPLPPPPPPPSRPTTSSVASNSSSSNSSSNSRDGGAAEIQQQQQRPQGRTKHQTKVANGLKAELSRLQPSSADTAAAVGGVPEQGTGRKLRSQESTRLKSELSNYFPEYDEIIGNDPKEEHLLNLETPIVIVPAANQAPISYDKYPVMSFGDHLFTDLWDSQVIDFSFLNSKVSHNLTEKDDPLPDSLFELPHKRAERQERSIRNTEKGRAKHEKEQVVRLLEGLQGPEWLRILGVHGPTTEAKRRQYEPAREYFISGCQAILDKFKRWTAEEKRRKQMEKDKAAAQQAAAAGSVESPQHDKEKEEKKSQPEKSKKKSARASKSREVDNDEEDQEVPDSEFDSDSDDGSGVYEEPAAFKGKPPDLDDHDDADVEKQLREEALAAAAAKRRTKSAKGKRTATTTSASSSSRCKKTVGPSKRPVSAATAQNKNRSASVPTTAPATGASSAKPKKKTADNNKGDKEASSSKSTKELTSFFTSRAQRDAALARHAFHPSTTSTSTTSRPTRRTTRSSEKILAWGHALPDVRETEFALPKDMLEDENLKEIRLTRSQSHNKKRRAEQKEENNDSDAVGASKRRRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGV0</accession>
    <name>G0SGV0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein transport protein sec16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0067660</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules. Also involved in autophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SEC16 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697057.1">
        <property type="nucleotide sequence ID" value="XM_006696994.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0SGV0"/>
    <dbReference type="GeneID" id="18260804"/>
    <dbReference type="KEGG" id="cthr:CTHT_0067660"/>
    <dbReference type="eggNOG" id="KOG1913">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001147_0_0_1"/>
    <dbReference type="OMA" id="NQPPPIM"/>
    <dbReference type="OrthoDB" id="8918678at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09233">
        <property type="entry name" value="ACE1-Sec16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1030:FF:000008">
        <property type="entry name" value="Protein transport protein sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024340">
        <property type="entry name" value="Sec16_CCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024298">
        <property type="entry name" value="Sec16_Sec23-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402">
        <property type="entry name" value="RGPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402:SF6">
        <property type="entry name" value="SECRETORY 16, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12932">
        <property type="entry name" value="Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12931">
        <property type="entry name" value="TPR_Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec16 central conserved" evidence="13">
        <location>
            <begin position="1170"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="domain" description="Sec16 Sec23-binding" evidence="12">
        <location>
            <begin position="1352"/>
            <end position="1663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="435"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="612"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="750"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1311"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1664"/>
            <end position="1686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1765"/>
            <end position="2320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="231"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="330"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="459"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="510"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="532"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="574"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="618"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="630"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="691"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="762"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="791"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="823"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="860"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="878"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="926"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="950"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1048"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1073"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1098"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1130"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1671"/>
            <end position="1681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1803"/>
            <end position="1812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1844"/>
            <end position="1860"/>
        </location>
    </feature>
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        <location>
            <begin position="1909"/>
            <end position="1925"/>
        </location>
    </feature>
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        <location>
            <begin position="1945"/>
            <end position="1963"/>
        </location>
    </feature>
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        <location>
            <begin position="1975"/>
            <end position="1989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="2004"/>
            <end position="2036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="2049"/>
            <end position="2066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="2093"/>
            <end position="2122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="2198"/>
            <end position="2211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="2223"/>
            <end position="2259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="2260"/>
            <end position="2275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="2276"/>
            <end position="2297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS17439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="2320" mass="245263" checksum="EDA45615C8F12906" modified="2011-10-19" version="1">MSSDTPSASWHPAMMPNSSADVEIQPEPALTQAQRAGASASDMQLESDNKEDGFDAWFTDQDLHQEGGQDNWFDEVAQTEAAPKIAQPEPTAEAEQPAIAETAQQELPETSHADPEAQLESAPAQQTSHVDPEAQVPEPAAQPELPDAESPQSESEQQSYPDPGAQPVLPEQPMTAETELVQVQAAAAGEMEPQAAAPEPALEAAEAGVTEPLQLEETQPPASAQPEATPEATQPASEQDPNQLESAEPTELQPETTQPAEPEPEPEPEPEPEPEPEQPQTPHSSHPEPQDLASPEPGPLSSAALKHFSTQSFTRTRVPHEASWSDDGEEWRSPRAESDNAKDPFKFLAESNRSNSFPLVSSPINEVAAEEGFGFGDNLEQEQQEIPRQQLAFSEAEDLIRDIEREELEEEKGGMPEAASVTIQELERAPTMDARFEEGVPLVSQQQENAAPSQAVDDLFADDGADEDDFFSNVRKEEAQPEPQPLQRKTTMDVLSQLGAGTVQPGVETIQEEEEEEEEEEEEEEEEEEEKEKEKEKEKEKEKDKEEAEPEQVKAEQARAKVEEETPQPAQAKVEPEPKETKEEENLDAKWKEMFADDEGLLLDDEEPKVDAANFLGSDDEGLLEDEPQPASALAPAVPASLPTTTAATAAPTTTTMTTTMTTTTTTTMTTAAPAPNPYVPAQPAQRQVSNPYVPATTAVPAPPTPTNPYLPTAPALTAAVPTPTPFSVTSTVPPAPAPAPAPTYGYSATPQYAAAPPQPQKKAESFVEKSKGGYQSPYDLPMEVVKVKPRAASSQRSAPAPTPSAPPRSASFQAHPPPPPARTASRPGSSHSSGPPSATSAKPRQESFFEELPIITKARPSSRTSHKSQSPTQLSPYGPPQTAPPPMASPPMASPPPHAPPTSAPAEPEIPKLVPPARVNPYAQLSTSPALSPVAPPASTSRYSPAPPGSSGLGPIPAPPSSRYSPAPPGSRNVSGSYGPVAGGPPILPHQPRTSSPLAHFEITHDRTRPHSSLPPTREVDEEDTAKAQVSPRAAGPASPPISRYAAPPPQAARQTPPPRPPAPTTAGLVVSPPRRAASSYSPLAPAAADLVPPPRSQTQSPGSSLYGSRGVKAEPVPRPSSVHGGASPPGVTRAAAAVPRPRAPSLNPNVIPPTDGREQDPLQRWRGCPLIAWGVGGTVVTMFPKEVPRYGMTMGGTAAGVVRSPGEVKVKSVKEILPLEERLAKFPGPLKGKGKKKEVLGWLSQGIEGLEKELAVSRVGVYVDWGEERRKTEERVLLWRVLRLFVENDGALEGSPAVVKAAREILTPSVPGGDNNNEESVPPYGNGANGLSPATGMAPDAVSSAVVEDIRRHLLRGDIEKAVWAAVDQRLWGHALLLANALAPPLYRQVAQEFVKKEVNFPGHNNESLAALYAVLSGNHEESVDELVPVHARAGLQLLAKDAAGPGAKVGADVEAGLDKWRETLSLILSNRTPEDGRAIRALGVLLASYGRADAAHVCFLFARAHTVFGGLDDPAAQFVLLGADHRKPGVEVAREIEALLLSEVYEYGLSLAAGASGGAFVGCPHLAGYKLQHALTLAEYGYRDKALAYCDAIAAAITAQTRRSVYHHALLETAVEDLMRRLKQAPSTESSGSSWLPKAPSMGKVSDTMWSRFNKFVAGDDDEDSATGAGANGEEAAGPFARVGAGTPTISRVPSSNNLEMFGSAAVPSYGVPAGANGPVPVPVPVPAAVVPPVPATRAASRPGIERTSSELSRMSVEIPARRSIDMQKGSGSGAYSPVRSGSPAVGYPPASQPVHRSGSPYTPVQYQPAQGLGMGQQGMESPYTPATTGTGTTIVGSPPVQGQQGYKPPSMTSYQPTPAEEENKPAGGYEPPSMTPYAPEEPKTSTYEPPSMTPYQPAASEESKPSTYEPPSSSLTPYSSSLEDDNNKRTSGGYEPPSLTPYETATEGSSRKSYAPSSVTLTPYETPPEEPNSNSNSNSNSNSNSKQEENGNGYGGGGYQPPEYGSYQPYGYGGYEPPSYEPGPESSSSSSSESEDEEGGDGEKKKKKDKEKQKKKKKKKRGIMYDDEDDDFPTVTTSTPRAETGVGSVKEKTKEEKDRENEEMFRRIAEEDAKRAEAAKAQQSQKRGWGFTSWLPFGKKDASSNTQDGTPGKPIKAKLGEPNQFYYDPELKRWVNKNAPQTAEKKVTPPPPRASSVPPGGAANKPPAGGPPTPGSGTGTPPAAAAGGAPPMIRSASGMSTASAPPSSTGTKPPTAGGPPPPAAGGPPKPKPSLSSSNSIDDLLGPAGLPPRRGAGGAAAKKKGRGARYVDVMSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGX1</accession>
    <name>G0SGX1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS9m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">37S ribosomal protein S9, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0067870</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="interaction">
        <interactant intactId="EBI-16104314">
            <id>G0SGX1</id>
        </interactant>
        <interactant intactId="EBI-16104192">
            <id>G0RXS6</id>
            <label>PRT1</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>2</experiments>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697078.1">
        <property type="nucleotide sequence ID" value="XM_006697015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGX1"/>
    <dbReference type="DIP" id="DIP-60995N"/>
    <dbReference type="IntAct" id="G0SGX1">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0SGX1"/>
    <dbReference type="GeneID" id="18260825"/>
    <dbReference type="KEGG" id="cthr:CTHT_0067870"/>
    <dbReference type="eggNOG" id="KOG1697">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036531_2_0_1"/>
    <dbReference type="OMA" id="RESAMWA"/>
    <dbReference type="OrthoDB" id="10254627at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000001">
        <property type="entry name" value="30S ribosomal protein S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023035">
        <property type="entry name" value="Ribosomal_uS9_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001099">
        <property type="entry name" value="PRK00132.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS17460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="319" mass="35598" checksum="75BBC2C42873F4B2" modified="2011-10-19" version="1">MMASTTRPGLVSALRGVSRRITSRQCRSLEHQFRLLSISTPCSSDMALEPIKPGSADIQAAPEIDLVALAKKYRLAEHARTVPASPSYFSKSPKFNDAFVRVEALYRKYGHLPTLPPADVERVAWKRLKDARTDFNERVKATDYVRCLFIVKSLHSIHPDLKPAEVTEALQVFKRDIQGFLNKPKPVPIDKYGRALGVGKRKASTARAYVLEGNGEVLINGKTLAEYFGRVHDRETAIWPLTATDRIDKYNVWVRVEGGGTTGQADAIKLAIAKGLLAHEPALKPALRRAGCITRDPRTVERKKPGRKKARKGLTWVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0SH65</accession>
    <name>G0SH65_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0068880</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697172.1">
        <property type="nucleotide sequence ID" value="XM_006697109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SH65"/>
    <dbReference type="STRING" id="759272.G0SH65"/>
    <dbReference type="GeneID" id="18260926"/>
    <dbReference type="KEGG" id="cthr:CTHT_0068880"/>
    <dbReference type="eggNOG" id="KOG1947">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010840_3_1_1"/>
    <dbReference type="OMA" id="PACTNWK"/>
    <dbReference type="OrthoDB" id="10257471at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF247">
        <property type="entry name" value="GH16156P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="92"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="3">
        <location>
            <begin position="181"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS17554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="784" mass="85939" checksum="BAA7A04FC9E69E8E" modified="2011-10-19" version="1">MRHHDLPDQAVGNGRSAPGPPNDTELEPDTDQTPRPPMDSRSTSSSGSPTPAEREEQEYDLYFGLNDSQSSLPVPNLKDMHVVDEYLPPVHCLPNEILIAIFSRLGTTTDLLHVMLTCKRWARNVVDLLWHRPACTTWERHSSICRTLGLENPYFCYRDFVKRLNLTAIAPQINDGSVLPFQDCTRIERLTLAGCRNLTDSGLIPLVENNNHLVSLDISLGDQITEQSIYTVAKHCPRLQGLNISGCTRISNESLIELAQRCRYLKRLKLNECTQVTDKTVLAFAENCPNILEIDLQQCRLVGNEPITAIFTKGRALRELRLVGCEMIDDGAFLALPPNKKYDHLRILDLSSCSRITDRAVEKIIEVAPRIRNVVLQKCRNLTDAAVYAISRLGKNLHFLHLGHCGHITDDGVKRLVSACTRIRYIDLGCCQHLTDESVKLLANLPKLKRVGLVKCTNITDASIIALAEANRRPRVRRDENGNAYTIPGDYTTSYSSLERVHLSYCTNLTLRSIIRLLNYCPRLTHLSLTGVPAFLRRDLAVFSRDAPPEFTQHQREVFCVFSGQGVVNLREYLNSSEVQEMHQFDDMGVSNQAGGPVFTTNPASAQGIPPLLQTADGGFEDGDADAVVDDDDGVDVSEMIIDGQPLPNHQVGLGLNTAAAAASPLPPPPLVPPSGRTNPTPLDYVAESSAAAAAAAAALFPQHFLPPIDQTGPVLVSAPMSSTHQAALTVNDEAVDVSLAMAINSAMNTPIAEEQTAPGAEQHGLSMSAVTSSLPRQNAPRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHC7</accession>
    <name>G0SHC7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Putative ATP-binding cassette (ABC) transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0069560</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697234.1">
        <property type="nucleotide sequence ID" value="XM_006697171.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0SHC7"/>
    <dbReference type="GeneID" id="18260994"/>
    <dbReference type="KEGG" id="cthr:CTHT_0069560"/>
    <dbReference type="eggNOG" id="KOG0054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_27_3_1"/>
    <dbReference type="OMA" id="RRRYILW"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000825">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF353">
        <property type="entry name" value="ABC TRANSPORTER ATP-BINDING PROTEIN_PERMEASE VMR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="507"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="536"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="614"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1045"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1139"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1214"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1242"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="329"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="724"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="1050"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1420"/>
            <end position="1692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="417"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="461"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="963"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1542"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1715"/>
            <end position="1768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="423"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="974"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1542"/>
            <end position="1561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1716"/>
            <end position="1727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS17616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1768" mass="196126" checksum="9ECBE90BBE6FA583" modified="2011-10-19" version="1">MGFAECSWPIWRVDDFTHCFQHDYLRVLLPLIIIGLSFVRLVIQNIVRAVRSKSPRGYERILNGGASISPATHTELPREEEPVSESEDEADLTIGGGRLALVKTTTRGSIVQADIPQAQTLSVFVEELAVAGLVAINTAALATGAYDDDRRRMSAIAGLVVWVYTLLLTSLRLFLGNTQWRVPRLWNHTATIYSFQWLFTLVIFRSALIHPASHLAQSLVIAEFALTSLLFGMAISTRKGNKTILLEWEDGIEPGRENLASLFSHYTFSWVDSIIWAGWKEPLTMKRVWNLLPRDKAAAVLASYRQVKRTTVLSLHLVKYFKGMLLAQAIWAAFGGALAFAPTLLLRQILEYVENPSIAPRNVLWLYVILLPVSDIVRSICDGQALWIGRKICINIRAILVGEIYAKALRRKAAAGNDSTLGAKKKKKKKKKRRRRDEEEEQGVKKKGLLAKAKRLLGLGKDSDDKKADANAQGPENKDKKGEPDEQANLGTIINLMSVDSFKVSEVTAYLHFLVAAAPVQLLVAITLLYRVMGLSAIPGFIVMALLLPVNIAFGKGFNSSQKKIMAATDKRIHTTNEILQNIRIIKYFAWEHRFSKIVDEKRRAELKALRTRYIIWAAAVAVWNTVPILITFFSFLIYTVVEKKPLYPSVAFTAISLFMLLRYPLDQLGDMIAHVQESQVSIDRIEEFLSEEETEKFAQLGIDNVDENGNRVIGFRNDATFIWGSKTAVKEDGTMAFRLLDLNVDFKIGKLNVITGPTGSGKTSMLMALLGEMTLIKGRVYLPGGRSREDVRPDPETGLAETCAYVAQQAWLVNASIKDNILFSAPYDEKRYHDVIVACALERDLEILDNGDETLVGEKGITLSGGQKQRISLARAVYSNSKHLLLDDCLSAVDSHTAQWIFNNCIMGPLMRGRTCILVSHNIPLCVPQADYVVTMHNGRIAAQGTPQELVAAGKLPEDALPRESAPGSAHISRVPSRVPSSVGEESGDTLVVNEADPDAQQTLRAENAKKKEAKKIDAMEEHKAVGSVKWPVMKLYLRSMGGWWFWCLACVVFTAQQLSGVASSIWIKEWSNQYTEQEEEKSSREAVLLFNVNSASYSAQTLSPTYFASIGTWVRDRAGFVSAAASADADGTPEVNVQYYLGILALIGLAGAATALIRDLWIFFGSLTASWKLHAGLMNSVTRAKFKFFDVTPLGQIMNRFSKDLEAIDQEVAPVAIGVMTCALGIVVTVVLIAWITPGFLIAGVFITLAYIFLGAFYLHASRDLKRLESVERSPLFQQFGETLSGVTTIRAYGDERRFIRDNLARINTQLRPFIYLWAANRWLAFRTDLLGDMVAFFAGVFVILSLGKIDPGSAGISLSYAIGFSENILWLVRLYAVNEQNMNSVERIREYLDVEQEAEAVVEKNRPESGWPSRGTVEFVNYSTRYRKELEPVLKNLSFKIEARERIGIVGRTGAGKSSLTLAIFRALEADEGKILIDDVDISTIGLRDLREAITIVPQEPTLFMGTIRSNLDPFDLYTDEQIFAALRRVHLIQPDEMPSASTGAALPAPTTASSSEQAADRAASDQQQADAIPTNKNPFLDLSSPVTESGNNLSQGQRQLLCLARALLKNPTVLVMDEATASIDYATDAAIQETIRELDSTIITIAHRLHTIADYDKVLVLDKGSLVEYGHPWELMKKKGGVFRGMCEMTGDFVGLRQVAREAWRKKVLVDVGDEEEEEEEDQRSEGSSGGEEGRRQEQQKGVSEEQPEQSAFEDSAPSAGQKP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>P0CU27</accession>
    <accession>G0SAE3</accession>
    <name>EFM3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein-lysine N-methyltransferase EFM3</fullName>
            <ecNumber evidence="1">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Elongation factor methyltransferase 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">CTHT_0041970.1</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EGS19715" version="1"/>
        </conflict>
        <text>The predicted gene CTHT_0041970 has been split into 2 genes: CTHT_0041970.1 and CTHT_0041970.2.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19715.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P0CU27"/>
    <dbReference type="SMR" id="P0CU27"/>
    <dbReference type="STRING" id="759272.P0CU27"/>
    <dbReference type="eggNOG" id="KOG2497">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3424">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF130">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EEF2KMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000437792" description="Protein-lysine N-methyltransferase EFM3">
        <location>
            <begin position="1"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="173"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P47163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q9H867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="336" mass="37265" checksum="811F0352628B4FBE" modified="2016-11-02" version="1">MVASRNPQTARFCWQYLQLEQSLDFPDGELLRDEAVQETIYQQLFAPNAPTPLPPARYRLRVLKELTSRIESAIEDWETHGISDNLMDAMAELVAQPLPSEAEAAQERCYVTYYLSLLEGGLEKPHITLLESRSLISASGTTGLRTWEAALHLGQFLSVNSGLVKDKRVLELGTGTGYLAVLCAKYLGTSHVIASDGSEEVVEKLSDNLFVNGLQDSDKVQPMELKWGHALLGTEEEHWNGGRKIDVVLGADITYDVSVIPALIATLEELVDLYPGISIIIAATERNRETYETFLAACGRRGFSVTPESFPVPSRAEQKGPFYKDGTPIHICQLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0RY33</accession>
    <name>G0RY33_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0005230</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691061.1">
        <property type="nucleotide sequence ID" value="XM_006690998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RY33"/>
    <dbReference type="STRING" id="759272.G0RY33"/>
    <dbReference type="GeneID" id="18254561"/>
    <dbReference type="KEGG" id="cthr:CTHT_0005230"/>
    <dbReference type="eggNOG" id="ENOG502RJK3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015560_0_0_1"/>
    <dbReference type="OMA" id="YPKRKRN"/>
    <dbReference type="OrthoDB" id="5235778at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="645"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="566"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="645"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="661"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="769" mass="83865" checksum="B3CBB7A53E1A5B0F" modified="2011-10-19" version="1">MDDRDSVESVSVREDPPMIKDSPSIVKSPSPIEPDVEPTEGPSMPISGSLSSLPEDHFESKSARESPADQPTDLKDQESIQDIPGNSLTQKDSDSSDTPMSPAIDPASISNRNANIGIDPIKEDTKESSTKSEPIEDINEDLTPPPESIADTIPSRASSVSLNDEIVVGADANNNTKASPTRATPESKDIEMGNTEDQPLAYHPKRKRSSVSADSDDEHEHSPASTEDHDSRRFIRPTKPAPLKGVVIGFWRDSPVPNDADKHSVIGFIDARDRLRTRIQPTTRDNRTIDHRYPIPPGPGGSWVTFDKIAFDEHLVGHNHHVVKEYVKLRAQTLQVKETPEQKAKRDKEAIDQAVYNITTNPPPEGAIAPLIAYGPDVPDNAVLYQRGDPNKRRRVDSGTFGGSEPSTPTSVANIPGTRPTRVLVGYWKHSSEPDPANKHAVFGILGANDMFRVKLARETRDGRPCHGNFPTGAGALWIHWDEVEFEPHLKQLTRAEIKEYCRVRQQQIDRGEAPEDRIANETKAVYQAQQRVASNLCYTPLASVAEAGFASDRSPPSVANGNGVAPASNSTPAAANPDESRRATRAATAAAAQQNGSTTRPNGRTPLPDIEFRAANRTNPMVEKTNNLATRAIARMETAQARQEMRIAAREAQQREREAAATATANGNNSTTSSISSGSSTAVASTSSSANRAMFQDHISRLNRVWASQEANRARAGNDPDTKVYMGIKYERKQSGPFQGKLVSSGTIISIDGEDYVEYRVLMKPSFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G0RY37</accession>
    <name>G0RY37_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative heat shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0005280</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691065.1">
        <property type="nucleotide sequence ID" value="XM_006691002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RY37"/>
    <dbReference type="STRING" id="759272.G0RY37"/>
    <dbReference type="GeneID" id="18254566"/>
    <dbReference type="KEGG" id="cthr:CTHT_0005280"/>
    <dbReference type="eggNOG" id="KOG0627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013966_1_0_1"/>
    <dbReference type="OMA" id="QWGQNPP"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000173">
        <property type="entry name" value="Heat shock transcription factor Hsf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="8">
        <location>
            <begin position="90"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="194"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="357"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="486"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="704"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="545"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="492"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="707"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS23823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="749" mass="80266" checksum="627D2BACF664FD31" modified="2011-10-19" version="1">MPTTTSANPYGQTIPAPSTALARRQTNSRALVPSGSRSFNGSDSWNDYNEPPPGGYLQAANAPIDDNDNIERLEELAARAKREAQAKRKQIPPFVQKLSSFLDESRNTDLIRWSEKGDSFIVLDEDEFARTLIPELFKHNNYASFVRQLNMYGFHKRVGLSDNSMKASERKNKSPSEYYNPYFRRGHPNLLWLINKPKSGSSKKKGKKDENENESEEDGGADDGYNGQNSLGRGVSNELAPLQKKELLQVKAQIERIQQQQVAISNMLNKLRENQNQLYQQAVLFQTMHERHENSINAILNFLANVFRKSLEEQGGAQSVQELLASIIPNAQGHGQSQMGSSANVVDLGGFVNQRGQGVGTPKRQQRLLPPAPHHTVSKASSLSTVATAPTPGHQRQPTMGTVTELFDTSPADTTSTGFIENELRTNPQEGMMKLIQDTNAVNNSGIDLPDVASKTSATMSDAQRTKMLNIMAGNNSTTTTAVTNGLSPLGAAPSTTSLSSVTSPTASASTTGSTPPALSSTTRPNALSLPLSTSLSTTPFLQDIQATQAEIEELQRLQSEQAAQIDELTSLLGPLSPSGRIPGLDEHGNPIGTNYFDNVDYDQFINSNAFADGNVDQISTATTGTTNAFGVNGTSTNGTASNQNGVVTAGDTDFDFSLDGTADGTDFVTSTAAPTPNDAATTALESSNGVAASAGNGFETGKVFETTSSTSATNSPSPTTVSDRAASVGATELFEESPERGTKRRRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0RY49</accession>
    <name>G0RY49_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transcriptional repressor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0005420</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691077.1">
        <property type="nucleotide sequence ID" value="XM_006691014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RY49"/>
    <dbReference type="STRING" id="759272.G0RY49"/>
    <dbReference type="GeneID" id="18254580"/>
    <dbReference type="KEGG" id="cthr:CTHT_0005420"/>
    <dbReference type="eggNOG" id="KOG0266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_4_1"/>
    <dbReference type="OMA" id="TIRTWPL"/>
    <dbReference type="OrthoDB" id="6262491at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="129"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="277"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="317"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="361"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="361"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS23835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="397" mass="43114" checksum="D3BB683365187724" modified="2011-10-19" version="1">MQSSDPRHFFESDAEVAKRERRAAKSSNKLGNPISLKSKILAAIPDPRAPSRSILVAEAAGCVRQVNLDSAYSPSQNPDEPSRPTYRGPTTPVCSVAVGGPNNGTLFAGCWDKTIWSWDLATRVPGRKFVGHSDFVKAVVCATVGGKHVLISGGADKKIIVWDVVTGQRLHTLQDSAVNMLSVQDLMVDVEASTKDEISLVSASSDPHIRRWKIRLDGWERVPDQSESGPGIILEHETTVYRLLLDQTGDDVDLWTASGDGTAKCLSRAKGFAVEDTITHGDHVRAVAVTDQWVITAGRDEDVKVWDRASGKLQCSLVGHYDEVIDLVVLDGGARVCSVSLDGTVRIWQLDQAGLDKAVKDQEKWAAGEQEKKEEAPASLLSPEEEAELAALMEEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G0RY58</accession>
    <name>G0RY58_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP-2 complex subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0005520</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Coated pit</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691086.1">
        <property type="nucleotide sequence ID" value="XM_006691023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RY58"/>
    <dbReference type="STRING" id="759272.G0RY58"/>
    <dbReference type="GeneID" id="18254590"/>
    <dbReference type="KEGG" id="cthr:CTHT_0005520"/>
    <dbReference type="eggNOG" id="KOG1077">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003824_1_0_1"/>
    <dbReference type="OMA" id="PVLMHRY"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000020">
        <property type="entry name" value="AP-2 complex subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017104">
        <property type="entry name" value="AP2_complex_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003164">
        <property type="entry name" value="Clathrin_a-adaptin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02296">
        <property type="entry name" value="Alpha_adaptin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037091">
        <property type="entry name" value="AP2_complex_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0168">Coated pit</keyword>
    <keyword evidence="3 7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain" evidence="9">
        <location>
            <begin position="716"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="21"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="66"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037091-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS23844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="985" mass="111091" checksum="8E29B089480B8B49" modified="2011-10-19" version="1">MASTGSSGFLGRSSGSSNNMRGLVQFIADLRNARARELEEKRINKELANIRQKFKDGNLSGYHKKKYVCKLLYIYILGFDVSFGHLEAVNLISSTKYSEKQIGYLAVTLFLHEKHELLHLVVNSIRKDLLDHNELFNCLALHAIANVGGREMGEALGADVHRLLISPTSKSFVKKKAALTLLRLYRKQPAIVQPDWAERIVSLMDDLDMGVALSVTSLVMTLAQDNLELYKGAYAKAVNRLKRIVLDGEYTPDYVYYKVPCPWIQVKLLRLLQYFPPSEDKHIREMLRETLQKILDLALETNKNVQQNNAQNAVLFEAINLIIHLDTEHALMKQISQRLGRFINSRETNVRYLGLEAMTHLAARADTLDPIKQHQDVIIGSLKDRDISVRRKALDLLYSMCDHTNATIIVTELLHYLQNADFAIREEMVLKIAILTEKYATDVQWYVDISLRLIAMAGDHVSDEVWQRVIQIITNNEELQVYAARNCLQYCKQDHCHETLVKIGAYILGEFGHLIAEEKGCSPIEQYLALSSKLGACSSSTRAMILSCFIKFVNLFPEIKQQLVAVFSIYSYSLDAELQQRACEYLTLANMPTDDLLRTVCDEMPPFPERQSALLSRLHQKHSNTSDKRTWVVGGKDANRDQAELNMAKQGGLRKTFTNGSQATGTSAANGQPTGAVNDLIGLDMNNVGPAEQKTVKVPNLASSAHLSPGWERGFNRLLLRTDGILFEDLQLQVGVRSEYRGAMACLILYFTSKSPSIMTGFTTTLDLDESEKGNITWDIKGMPDPTLSHGGQTQQVILFEAKRVFQKAPTIRISYLSGSLQWYTLMLPLAIHKFMDPAELSAEDFFKRWRQIGGAPREAQKIFGLAPAARDAKRELNEDFIRRVVEGFRWGILRGVDPNERNFVGASVVHTTEGGKYGCLLRLEPNYATQMIRLTIRATDESVPPILLKMMEERLVVGMSTQTEKRPPPTVSEISDAFRNVMVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0RY96</accession>
    <name>G0RY96_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0005910</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691124.1">
        <property type="nucleotide sequence ID" value="XM_006691061.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0RY96"/>
    <dbReference type="GeneID" id="18254629"/>
    <dbReference type="KEGG" id="cthr:CTHT_0005910"/>
    <dbReference type="eggNOG" id="ENOG502SYJI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_236634_0_0_1"/>
    <dbReference type="OMA" id="LWEFEAQ"/>
    <dbReference type="OrthoDB" id="3946221at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="846"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1342"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1417"/>
            <end position="1685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1698"/>
            <end position="1731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1766"/>
            <end position="1797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="746"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="783"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="795"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="813"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="912"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1013"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1063"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1110"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1132"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1208"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1234"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1251"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1272"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1286"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1307"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1342"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1363"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1390"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1430"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1442"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1527"/>
            <end position="1563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1574"/>
            <end position="1587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1588"/>
            <end position="1603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1623"/>
            <end position="1632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1633"/>
            <end position="1676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1713"/>
            <end position="1726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1783"/>
            <end position="1796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1861" mass="207910" checksum="3BBAD02F6B04285B" modified="2011-10-19" version="1">MDDEPERTIILDLGSSPDPLIDPVLSPPMVNNSAIKTWSPAAKRLYTLNPDSVSRPRPSPRRSPRKRTFELDVGDERSPQRLRVTVEADPAGSSPRNDSTRRRLFRSPTPGAGRRKSTAMRETTITTTVPVRGLSDDEGDAVTPGRRAPRRAGTPVATTGKKKRPGTPARRRDSRAFEISPRKDVLVEDMDVDPGTPGPAVPGSVSTAKRATKRKVVSPAPASQPRKRGRPRKSQAVPPAGEDKENDGVVEEGKGKGVVSEDISNAIRDSRAGENNLESDIWLASLSDQPTPVPARRQTQREPELPSRNEPPFEPQPEPPRDEPQDQGAHDWPELHDAPGGDWSDRESDGERRDHDDRDLHQDTIMAGEGFTMISIHSLPSMQLKSSQRLLDPPQEEGEEDKELDEEANQIINRTLESLRQSLNNRSSQLGPQPPANADSNPQTAEPETRLNEEPEQAPVEPEPEQVPEPTHHEPSSPSPQPAPASSSPHEKSFLLEKPRRPRRSLNPLQATQPNETLNSRVYKSSFSSIPSVILASPTPGPSSSEQQPEAEAEAPHEEEEKEDIQPSIERPSRVHDPQQHLDHSRMLTPDETPSPVPSEQGGHDDVHEHEPEPDSERQPSSSPLPEPPRPQFEQLPPQLPRQPHENEQPELHSSPPTTRPPSANLPLPRTSGHLRAPSTETPVDQLAPFAAPPPVLLPEPAQPLLPQPTTGRATRPSLSPIVRAGRALQIVTSDPPSPPGGGSLLGSPFKGSFSRRSASPGASHPPTTTSERRTRSRSSSPEQEKEAEQDHSNEVSGGQDSSGGWTWGGDKATTTAPAAAAVPSSPSKSWLAPLTQLKDFVTRTAAQALGSSSPRRGRGDDGSAAPEATTAAVKSSVEGVIDDPFGPDPEENAEQGGRRTLFSGPGRGNRWRAERERLEREWEEREQLERDKLEREERERSRAAEKGQRERERERNRLAAERERKERLERERRIAAERERLEQERLVAEREAREAARLVRRRGEDEMSLDGSPRHESEKEEPRKEPGRQTSRESFSRLSREQPSETQPEVNGPEPMQVDQAQGEDEDSDEDIWAIEAERSASMTAPNTTTTTALPQQRREPVATSHAPAPGPAPAPRRPSPQDTWHRDNRPQTYTDEAQPSSEANGNGPLQPQTQSQPEARRQSSPNDEMNGDEELEGFSMVARNNRPEPPRPTFTKPVKTKPNLDSFFSSPATLPDITQASRGLFGMRAGDATTQQQQSVSRPEVGTGTVSGTGTGTGTGGGLFSRYLQPRREQESHQQQREPELEEEEEEEPEEEMPPPSVPQKEFHISRERSMDLFSSSPMRNPTPAKHLLRKAIVQAQQPITRGMSPSSDLSFQDQDEDHHGREEVRGEMQTRRERVSKGDGTAVGQNKSTATTAAGTSVFAENSQIDDFFAQFKPAGWGRGRSRQPQSQIQQSQPTPEPEPQPPSQPHQQPQSDHRQHRQALANHYDDSDSDSIPPPPVLRPLPNHREASPTKSALRSPLKPKTPGPVVEFTSSTLSPNEQARRRAERRKEREHEREDGRQSRQGQRLEEMEMERGRGGRVNGRRYEEEEELPESDGEVEADGGHRERELDEGKYDYEYEEEVEQPRQRSAAPQPEHGSESEFEHEVEQEEQESDYDNEEEEEEEETEEEEEEEEEEEEEEEEEEEEEEERPPLSSRIASKFANLFARRATLLATPSHPTTNVPDSPRPEPESQQRRPQPDDDDTWTRTHWLLLDSLLQSRKQGTLYFQLHLANLQRRHNRHSRLEPDPEPVFKTPGRSISSSGGSSRQRLLGKVVTSQGERMTIEGWHLDVVEGFLELQEKEGNKWGAEEIVKRVFALLVGEERRRRGLVPKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYC5</accession>
    <name>G0RYC5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0006200</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691153.1">
        <property type="nucleotide sequence ID" value="XM_006691090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYC5"/>
    <dbReference type="STRING" id="759272.G0RYC5"/>
    <dbReference type="GeneID" id="18254658"/>
    <dbReference type="KEGG" id="cthr:CTHT_0006200"/>
    <dbReference type="eggNOG" id="ENOG502RWR6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019222_0_0_1"/>
    <dbReference type="OMA" id="HNRHLNM"/>
    <dbReference type="OrthoDB" id="5395390at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052109">
        <property type="entry name" value="SRRM_Domain-Containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34755:SF4">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34755">
        <property type="entry name" value="SERINE/ARGININE REPETITIVE MATRIX PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="637"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="642"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="847" mass="95273" checksum="13C77C4351A2241D" modified="2011-10-19" version="1">MTSTAFHMPLDNRRVLRPRPPPALPPPRLNGPVTRRLAALVAANPNLVSAIENGSPSPEPTPSPPLRTSSRLRKRSPSPTAEASTRRAAKRARHRRRSQSESDEDSDFDNDGPTQRRGAHLTRIGGRQARGAAVEHATPRKSAAVAASESRRGKPSLASAAVSKPSKSRSGGTLLFDKSPRGGNKNAMNEKEADPETIPPWATLPYHVLVQIFRYAAALLADDWERAKWLRAATGICRAFAEPAITVLYESPPLLTKAMAHQFIALLAKDPATTMFNYRQKVRELRIDPEELAWRPYRGQLLDLSALVTLPRIQSITLYHPKDGPPYRDLDENLRWHYPMSLFDALNGVQTSSSPDESTSALSQQPTKPTRLTEWHWNRRMMGSKVTLSDIKSLHQTPAFSSLKKVTFLNYQLPSMRDYATSEDVLAARDKAFVAALADAINALPKLEHLTFESSTAVCGQLLAVLPRNLKTLEITNCWDVDSDALAEYLTSGGKQLRQLLLRYNQSLSLAFLVVLRDACPNLRTLVVDLKTYRHHTFYDDSDPEYSAVLEPTQTPTWPESLEVIELKNMRKWTAEGAETLFRSLVDAAPNLSNLRRIDLKAMLDIPYRQRSKIRDRWAATLRHVFLRERSDPMPLSTIHRRKEEDKDMKMADVEEIENKSPGRGRRATNVTPSRKSARLAAKEQQQHHHQQHQQQMEDPFRPSNCTHSLRSGVTRPSYVEPDTDIDLDSDADSDNDNDNDGQPYTPQKKRKSSSNTISGNPTPRLASLDDEDSSQPGSPFDPSELEGLYRQGLCDVVEIQLDNQKPAETMFVMDDFLDDEPDDLEDEEWDGVDDFEFQAGGWGWAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYS6</accession>
    <name>G0RYS6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0007740</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS24062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691304.1">
        <property type="nucleotide sequence ID" value="XM_006691241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYS6"/>
    <dbReference type="STRING" id="759272.G0RYS6"/>
    <dbReference type="GeneID" id="18254812"/>
    <dbReference type="KEGG" id="cthr:CTHT_0007740"/>
    <dbReference type="eggNOG" id="ENOG502QR0K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021595_0_0_1"/>
    <dbReference type="OMA" id="DWYNTEH"/>
    <dbReference type="OrthoDB" id="2851338at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="302"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS24062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="542" mass="60157" checksum="B1997CF64DFADF95" modified="2011-10-19" version="1">MAGNGPGMLYVTMQPREGLSLDQFHEWYNNEHGPTRLRLPHIFTNGLRYRAIDGEQPHFLAIYDVTNMAHLLTPIYTDLRSNRTPREAATIGQVDVDRKFFDLVATQQSPDFVPSEQLTDEEAVGRVLVSVEVSLKPGVEGAQEAVTKWYVEEHLPMLSKVPGWLRSRVYLTPSAVEGTANDARIVTLHEYTKENGLGGPEHKASMTTSWRDEIFSKYIANKGRRVYELFYVFGPGPRELYSLSRLPASAAFSTADGLIRTTPGEKTAAIDAFVNTVDGLAIPYRLEGNPSPDAPTVAFSNSLLTSLNMWDPLVAIFKEKRPDLRILRYNTRGRHDVPTPPVPATMDMLADDLNTLLTGLRIPKLHALIGVSMGGATTLKFALKYPQRLERFIACDFNVASSEANTAAWKDRIAVAESTDGGIRKLAGLTVERWFHPHTMANKKSVADWMTDMVATNSVQGFRWSCQALWNYDMREEMKKNTIPGLFVVGEGDAKGVLVKAMDSFKGLLGPSGAELKIVPLAGHLPMCEAPEEFWEAISGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYY3</accession>
    <name>G0RYY3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0001000</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690653.1">
        <property type="nucleotide sequence ID" value="XM_006690590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYY3"/>
    <dbReference type="GeneID" id="18254138"/>
    <dbReference type="KEGG" id="cthr:CTHT_0001000"/>
    <dbReference type="eggNOG" id="ENOG502RWK6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053730_0_0_1"/>
    <dbReference type="OMA" id="MAYINNQ"/>
    <dbReference type="OrthoDB" id="5290015at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="307" mass="34580" checksum="913FCD9B43EF82BA" modified="2011-10-19" version="1">MHDMARWGSYGIYVNGIGNLIIIDEGENPHTVVPWNSWVFTTLATCINNGIQVLETPQGRAALFKLGNLVVQEWEKEGRWVFGGYLAKMTYYVDHFLTAVRRDFPFVKLQRIDHTTLAETVRLNRSEDSDMLWWDGDLENYQPKLAARMSFQRTIILQLAQAADLANRPAKSASEARKVSQHYKSLLFRISMAVAHELAHFFVAYLAQRDTPDMANYTPTNVTVLNHGVFDNVQDFTARSGSSSSDHSDDWWVSGESGSWMENELFGGLIEALYDPQVPELDPERPISTSPSNAKAPSTPSATWAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZ07</accession>
    <name>G0RZ07_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0001250</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690677.1">
        <property type="nucleotide sequence ID" value="XM_006690614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZ07"/>
    <dbReference type="STRING" id="759272.G0RZ07"/>
    <dbReference type="GeneID" id="18254163"/>
    <dbReference type="KEGG" id="cthr:CTHT_0001250"/>
    <dbReference type="eggNOG" id="KOG0737">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004223_0_0_1"/>
    <dbReference type="OMA" id="IFMHATD"/>
    <dbReference type="OrthoDB" id="39734at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051701">
        <property type="entry name" value="Mito_OM_Translocase_MSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644:SF56">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="826"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="19"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="743"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="743"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS23435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1127" mass="123079" checksum="FD26847170490763" modified="2011-10-19" version="1">MPSAAGARALLSVSVRESAASASASHCRARSRPRLPPARVPIQIQQQANVHNAARRRCSSNGPAPPRNPVSVVTPQNRGFHASVAVRGRSSEDPGAADDPSKEGSAGVPNKNSHSAKENATNSTTSGKETPDTSAKPPAETPAQPPVEVNNKRERLRSQGYGSARARATRNLRVDETVAVQLPKWFMDDCVSLYEQRPIGSPNTLLLPLLEQDREDVAAVLDARIEEAALTEDDVAAAKEKLLRAAQRGVAAVAPVAEQLVGRARDVHNAAFFQALAMVHTDSADPEHLDRLRQHYAERASEMERLAWWPDEKLSLDAQRWLANLRSEAVPGSGSLHGSPLAKRPSVEYPVCMELLAAIRTQLETPPPISQHPNSRRPVNILAVLNRKGRTVPQSVINDIATDLNADVVHLDAHILADLIGRHLGQNPYAARGSLTMLGYGAAELNGRLAPRPDPDAELNLGMVSVTLPPRLRSFRSLYKDSYSAGASSEGRWDDLKMGTALETLISAAEIKRGLMRAQEEERPKFSVPAQNLIVHVHDFAELSSLHPSLITKLRTIVDRMWLGGRRVVLVGSSSGDQNSPSRWRDQLADLGQDGDHIIPFQADESSQWTELYDNVRDNLANVEAMLRGMLGFNADINLGKVRIEDGPALVDSKEGSVGKVFSSHLYDAQWIYRLASLMVGCRAPRYDKFRLSNLEYALQYMSDQNKHWSSICPSVHPPYFSPLLTPRKNRGEGVEWDFSLSSGGGGGGDGRGGSGSGGFGGTSSSKEYDQHEKKLLSGLINAKDLHTTFDDIVVPQETKDSLIGLTSLSLIRPEAFSYGILKTERVPGCLLYGPPGTGKTLLAKAVAKESGANMLEVSAASINDMWLGQSEKNVRALFSLARKLSPCVIFLDEADALLGARQNTPGRSGHRETITQFLREWDGLSGPSNPDQRAFIMVATNRPFDLDEAVLRRLPRKILVDLPLRAEREKILRVMLRDEVLDSDVDIAYLAGEPTELYSGSDLKNLCVSAAMEAVREEVRLRDAHTGDEPFVWPEKRVLKKKHFEKALREISASISEDMESLKAIRKFDEQYGDAGRKRRAKRGIGFEVVSGKVGSGEARVRQVAEDGGEEKGVAVGVKVDESAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZ79</accession>
    <name>G0RZ79_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0002010</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690749.1">
        <property type="nucleotide sequence ID" value="XM_006690686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZ79"/>
    <dbReference type="STRING" id="759272.G0RZ79"/>
    <dbReference type="GeneID" id="18254239"/>
    <dbReference type="KEGG" id="cthr:CTHT_0002010"/>
    <dbReference type="eggNOG" id="KOG1716">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003560_1_0_1"/>
    <dbReference type="OMA" id="NKPYSRQ"/>
    <dbReference type="OrthoDB" id="273181at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033260">
        <property type="term" value="P:nuclear DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14516">
        <property type="entry name" value="DSP_fungal_PPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000110">
        <property type="entry name" value="PPS1p Protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053239">
        <property type="entry name" value="Dual_spec_PTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047949">
        <property type="entry name" value="PPS1_DSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47550">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE PPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47550:SF1">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE PPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="483"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="543"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS23507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="696" mass="77528" checksum="1D5D61ABE02DAA1D" modified="2011-10-19" version="1">MATITLSRPITPHSSSSNLTLDSRDSRDPTPCPSPVPNKHIPICPPGPIPREGPTTPPPSPPSEHHQVQKSLLYPPDRYRCLAMGQLAIYMLSAADIAAAVHYHAQQPLPDPSQVFPWLHGLHPSNHLQQAFVNARRRSTRKTPACLRGITIVKADGDLSVARLKGAVAPHEILLMGAGVADFLDLDPKEGFSARNFHIQTAKMATTSDIIVYGADDVAVRKLAWEIAVAQMRWREEHNDPHHPLPRYNTFICVSPWSEFEMYHPELIAVNSLGNPTGRVFDFAHQERREMYEMARASEISHNVWLGPTPEHGSPDQHGYALLIECSDIGRLNPKNLEYIFGMIAKGSLKVQYQADFPSSGSLLVSNSVSGEFDAFIESLKWIMEIANLGHKVLIHCADGYTESTLLAVAYHAYSTGTPVYDSWLTLHTQLGRNMFAYPTDAFLLSFLGSRLLRESPVTASLERPIPVVYDEPAWFVQFDGSFPSRITDYMYLGNLGHANNPELLRKLGIGQILSVGESVEWSAETLREWGPENTCLIQGVQDNGMDALDEMFERCLWFIDRGRKSGKATLVHCRVGVSRSATICIAEVMRSMRLSFPRAYCFVRARRLNVIIQPNLRFTYELLKWEEKLKLKSNFGASASINGEMDCDGYGDCSGSDCSGDSDCSQEGGFKREMEWAEIAREIAALNKPYARNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZ87</accession>
    <name>G0RZ87_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pumilio domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0002090</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZE6</accession>
    <name>G0RZE6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">General transcription and DNA repair factor IIH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CTHT_0002690</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2017" name="Nucleic Acids Res." volume="45" first="10872" last="10883">
            <title>The intricate network between the p34 and p44 subunits is central to the activity of the transcription/DNA repair factor TFIIH.</title>
            <authorList>
                <person name="Radu L."/>
                <person name="Schoenwetter E."/>
                <person name="Braun C."/>
                <person name="Marcoux J."/>
                <person name="Koelmel W."/>
                <person name="Schmitt D.R."/>
                <person name="Kuper J."/>
                <person name="Cianferani S."/>
                <person name="Egly J.M."/>
                <person name="Poterszman A."/>
                <person name="Kisker C."/>
            </authorList>
            <dbReference type="PubMed" id="28977422"/>
            <dbReference type="DOI" id="10.1093/nar/gkx743"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 368-534 IN COMPLEX WITH ZN(2+)</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="journal article" date="2024" name="Nat. Struct. Mol. Biol." volume="31" first="1580" last="1588">
            <title>XPD stalled on cross-linked DNA provides insight into damage verification.</title>
            <authorList>
                <person name="Kuper J."/>
                <person name="Hove T."/>
                <person name="Maidl S."/>
                <person name="Neitz H."/>
                <person name="Sauer F."/>
                <person name="Kempf M."/>
                <person name="Schroeder T."/>
                <person name="Greiter E."/>
                <person name="Hobartner C."/>
                <person name="Kisker C."/>
            </authorList>
            <dbReference type="PubMed" id="38806694"/>
            <dbReference type="DOI" id="10.1038/s41594-024-01323-5"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.10 ANGSTROMS)</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the GTF2H2 family.</text>
    </comment>
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        <property type="resolution" value="3.10 A"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="von Willebrand factor, type A domain"/>
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        <property type="entry name" value="C1-like_sf"/>
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        <property type="entry name" value="Ssl1-like"/>
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    <dbReference type="InterPro" id="IPR004595">
        <property type="entry name" value="TFIIH_C1-like_dom"/>
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    <dbReference type="InterPro" id="IPR012170">
        <property type="entry name" value="TFIIH_SSL1/p44"/>
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    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00622">
        <property type="entry name" value="ssl1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07975">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04056">
        <property type="entry name" value="Ssl1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="C1_4"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="19 20 21" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 11 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
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        </location>
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            <begin position="1"/>
            <end position="55"/>
        </location>
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            <begin position="1"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="14">
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            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
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            <begin position="425"/>
            <end position="447"/>
        </location>
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    <feature type="binding site" evidence="19 20">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
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    <feature type="binding site" evidence="19 20">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
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            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19 20">
        <location>
            <position position="479"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
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        <location>
            <position position="484"/>
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        <ligand>
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            <label>1</label>
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        <location>
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        <ligand>
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            <label>1</label>
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        <location>
            <position position="498"/>
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        <ligand>
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            <label>2</label>
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    <feature type="binding site" evidence="19 20">
        <location>
            <position position="501"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGS23574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="19">
        <source>
            <dbReference type="PDB" id="5NUS"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PDB" id="5OBZ"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="21">
        <source>
            <dbReference type="PDB" id="8REV"/>
        </source>
    </evidence>
    <sequence length="534" mass="58018" checksum="161ECEA35A8D2182" modified="2011-10-19" version="1">MADSDGEYVEDLSDDELHDHRPAEAGPHGARSKAGAGKKRDGKKGKKGSSRHTKAAWEDIQRSWENVVETEDGSITIEALIEAEKRRRLMRDTTPLQRGIIRHLVLVLDMSFAMAEKDLLPNRYLLTLNYAVDFVREYFEQNPISQMGIIAMRDGIAVRVSDMSGNPADHIERLRFWAEHQEPQGNPSLQNALEMCRGALYHTPSHGTREVLIVYGALLSSDPGDIHETISNLVKDRIRVTVVGLAAQVAVCAELCTRTNHGDDSTYAVALHEQHFRELFLAATIPPPATASSATDKNGANGNANAASTDASLLMMGFPSRTLASASHVSLCACHSRPSREGYLCTRCRAKVCRLPAECPACGLTLILSTHLARSYHHLFPLKGWVEVSWAEARKSKQVGCFACLAPFPLPPAPGSEKTGKEPTQKTQGQAQQPPQERQGSSSNSNNAKKTTGISLATALPEARAVGVSESGRYKCPTCGKHFCIDCDVFAHEVIHNCPGCQADMRPKQDASSNNIGPANGLNNVVDGDAMVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZF8</accession>
    <name>G0RZF8_CHATD</name>
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        <submittedName>
            <fullName evidence="2">Export control protein CHS7-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0002810</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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    <dbReference type="STRING" id="759272.G0RZF8"/>
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    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:unfolded protein binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Chs7"/>
    </dbReference>
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        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329:SF1">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12271">
        <property type="entry name" value="Chs7"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="53"/>
            <end position="71"/>
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            <end position="176"/>
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            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        <source>
            <dbReference type="EMBL" id="EGS23586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="260" mass="28576" checksum="D691CA192C1ADBBF" modified="2011-10-19" version="1">MGSTKFGNFDILCRDTTLPICNLISPFHNQTGPWDGCSLKGIPLSGGRHLGNLGTILLCGAAIATTIKLLVRSERKRAAVGRSAIHIGAIAATTWILFINAVIGYQLMDDGTPLSVFLTGGSGLVFLIGVGYIALDTGFQFTDFWNDSYNSPNRHIALYVLYLIVPLLWIVLYVVLESYLVLKILGEIRPMFFLLGSAFFFAAGQVFNFAVSSHICEGTSGRIDGSLFQTFFTLLSVVAVWLFWSEITEDDWQDNITPYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZG3</accession>
    <name>G0RZG3_CHATD</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">CTHT_0002860</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690833.1">
        <property type="nucleotide sequence ID" value="XM_006690770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZG3"/>
    <dbReference type="STRING" id="759272.G0RZG3"/>
    <dbReference type="GeneID" id="18254324"/>
    <dbReference type="KEGG" id="cthr:CTHT_0002860"/>
    <dbReference type="eggNOG" id="ENOG502S0PN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061830_0_0_1"/>
    <dbReference type="OMA" id="WIHIWIA"/>
    <dbReference type="OrthoDB" id="5397827at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="283" mass="32459" checksum="0CD1D75DB542C90E" modified="2011-10-19" version="1">MSSATATIPRFLLPQTGSIWRRQIFVRVPTTWTSQLTPLTPVIIRLSSSNSKPATNAQGQRLLAKPERFTPPSHPSALPRKNAPRVYGGDLSAEEKKAQEEKHYPGLPPPPGSKAYKFIHSRWIHVSITLGTLTVLTIWTLVLDFQKNSPFADMLPSTSDFLARPLTSLYMVVEVLRLHEAHKSAQIAEKRKRYVEDVAKRRAYRKAHGLPEEVGLFNQPMARIKTDEEIEEEKRKAAEEKEQQRLQEEEETKRRKDPEVRPLTEEERQEVVKQIKGKWLGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZP2</accession>
    <name>G0RZP2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell surface protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0003670</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690912.1">
        <property type="nucleotide sequence ID" value="XM_006690849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZP2"/>
    <dbReference type="GeneID" id="18254405"/>
    <dbReference type="KEGG" id="cthr:CTHT_0003670"/>
    <dbReference type="eggNOG" id="ENOG502SN39">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047729_2_0_1"/>
    <dbReference type="OMA" id="GRRGNIA"/>
    <dbReference type="OrthoDB" id="5418436at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021476">
        <property type="entry name" value="Egh16-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618:SF4">
        <property type="entry name" value="CAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618">
        <property type="entry name" value="SURFACE PROTEIN MAS1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11327">
        <property type="entry name" value="Egh16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408673" description="Cell surface protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="25072" checksum="C257CD8354CCAB89" modified="2011-10-19" version="1">MQPSLFLLGLLARLVSAHGKITVVTGNAGGNGTALGIQGGVIPSEGNSGKAQSDTTIFSSTKLLSAGLGKTTGSGKNTISMLVDAMALSGPILPQITPGGSLSGTWRIVTADGAGPIGAVIDPTAKGNFTTGIPLTVVQQVPGYKGNFIFPEDQKVEEKRSIFRRAMDAASSVVLSKRAARTVQQDFAFEFAVPANVTCNGVIAGLRGVCLVKIANAHKAGPFGGVVAVQMATASEGAKCSREFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZP9</accession>
    <name>G0RZP9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glutamine--fructose-6-phosphate transaminase (isomerizing)</fullName>
            <ecNumber evidence="4">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0003740</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="4"/>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690919.1">
        <property type="nucleotide sequence ID" value="XM_006690856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZP9"/>
    <dbReference type="STRING" id="759272.G0RZP9"/>
    <dbReference type="GeneID" id="18254412"/>
    <dbReference type="KEGG" id="cthr:CTHT_0003740"/>
    <dbReference type="eggNOG" id="KOG1268">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012520_5_2_1"/>
    <dbReference type="OMA" id="ASEYRYA"/>
    <dbReference type="OrthoDB" id="15235at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00528"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00714">
        <property type="entry name" value="GFAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000001">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000002">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GFAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047084">
        <property type="entry name" value="GFAT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001484">
        <property type="entry name" value="PRK00331.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937">
        <property type="entry name" value="GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="GLUTAMINE--FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="11">
        <location>
            <begin position="51"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="12">
        <location>
            <begin position="429"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="12">
        <location>
            <begin position="601"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS23677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="752" mass="83542" checksum="63C2DDFF7A8C51C0" modified="2011-10-19" version="1">MWYETASPLFPPESVPQLCPELLFVVTVRGVSQMGRDGVFRTQRIPPDALCGIFGYVNYLVEKDRKFIIETLINGLLRLEYRGYDSAGLAVDGDKKNEVFAFKEVGKVAKLKQLIDEAQLDLTKTFDSHCGIAHTRWATHGPPSRLNCHPHRSDPSWEFSVVHNGIITNYKELKTLLESKGFKFETDTDTECIAKLAKYIYDQHPNVGFTDLAKAVISELEGAYGLLIKSVHYPHEVIAARKGSPLVIGVKTSKRMKVDFVDVEYSDENTALPAETASQNVALKKSSGSGSLLAPNGLLAAADKSLLHRSQSRAFMTDDGQPMPTEFFLSSDPSAIVEHTKKVMYLEDDDIAHIHEGQLNIHRLKKADGSSNVRAIQTLELELQEIMKGKFDHFMQKEIFEQPESVINTMRGRLDIANKTVTLGGLRNYISTIRRCRRIIFIACGTSYHSCMAVRGIFEELVEIPISVELASDFLDRQAPVFRDDTCVFVSQSGETADSLMALRYCLERGALTVGIVNVVGSSISLLTHCGVHVNAGPEIGVASTKAYTSQFIAMVMFALSLSEDRASKQKRREEIMEGLSKISDQIKAVLEQDQKIKELCEKKFKGQKSILLLGRGSQHATALEGALKIKEISYLHCEAVMSGELKHGVLALVDENLPIIMILTRDNLFKKSLNAYQQVIARGGKPIVICNEGDEEFKSSQAEKIEIPKTVDCLQGILNVIPLQLIAYWLAVMEGLNVDFPRNLAKSVTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZX5</accession>
    <name>G0RZX5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0007970</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691327.1">
        <property type="nucleotide sequence ID" value="XM_006691264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZX5"/>
    <dbReference type="STRING" id="759272.G0RZX5"/>
    <dbReference type="GeneID" id="18254835"/>
    <dbReference type="KEGG" id="cthr:CTHT_0007970"/>
    <dbReference type="eggNOG" id="ENOG502SGEW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029865_0_0_1"/>
    <dbReference type="OMA" id="DEMGVWE"/>
    <dbReference type="OrthoDB" id="336321at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="437" mass="47422" checksum="74F379BB02292D6F" modified="2011-10-19" version="1">MDLEACSPGQLEPVPASILLDHELAKRKLADKKGRIVTGCSALDNYVLLGGFERGSVVGVSAEDEELGLLLGLQMIACTLTSNTCARTMIVTTLPTAMILPKLRAALMNQLSAQGLDSLQSRVKQCLERISIARVFDIDGFKEVLKELGEAAISAETHAQELQKNAKVPGAGEPAKSHQQAVPEERERTEIPDSEEEDLCSPEPLPQEPPDIQLPPAELAQTVSSVPDIVLVAHMSNLLNALFASRDKQPAHDTMLLLSSQLHSFARSSAMNGPVFMLLNSTISPTSSSHDESIIGKGMKLSKQVEPTLCSIFNPAPQSSPLRRHHPCNVPGRFVRDPAQRNKPAFGQVFAQMVDLHLLCTRVPRTKVDAAAVAARPGGGLVEVSYTWVVEVLLDETGVLERVVADHMGDEGWVRRCREQRWAAVDVDQGRIVDAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0S077</accession>
    <name>G0S077_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0009040</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691429.1">
        <property type="nucleotide sequence ID" value="XM_006691366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S077"/>
    <dbReference type="STRING" id="759272.G0S077"/>
    <dbReference type="GeneID" id="18254942"/>
    <dbReference type="KEGG" id="cthr:CTHT_0009040"/>
    <dbReference type="eggNOG" id="ENOG502RXKM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_307176_0_0_1"/>
    <dbReference type="OrthoDB" id="432536at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053275">
        <property type="entry name" value="Agnestin_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38688:SF1">
        <property type="entry name" value="FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38688">
        <property type="entry name" value="PYR_REDOX_2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="910"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="963" mass="110612" checksum="FF997C6A92F4A472" modified="2011-10-19" version="1">MDGQGLKHFLDDAETPADAQHPTCSTSPALCLDPKGVQADDWQARSVFWMLPGPPTAERTATAAEMRSSALYAPIIPLAILGPVATQAEFLAYCDKLREMRTPPSERLYCHNKSNPRCSVMFLSGRIGRDYTQHQRRALRMALRHKQEAEQQQKKGTKEGGQPTQEKVSKRLKASKNLEKPLPQIPLSYSRRITSTTSPYGQKASHNSAAARAETARQLPADSTQRSKPASSVLREQSRQQHNWGNTRAGKVGWTTPAISSGKIKYQAPQSEPRLSKGIGFFRRHKASRKPRLNEIAQYYARQLVKIYEGKEKMYYIPDSGIPRAEAIVLGAGPAGIAAVANLLEVMDELEGNIVWVDPLFDCGSIRMYRDVQSYSTVEDFLSYAHRNRILRSILQSVPPSENPVERLQMLPRQGTCKLGMVYDMLKLFTEGLRKHKRVESITGTVTFATRDSISHAWSVSIRPDEIGFDVQPILRESHAIAFCTGCHPRTENLRLKSSSRIPLETALSKNGLIQALRRVNKPPTVAVVGDGHCAVYVLKNLFELATSTHPGLRVRWITRTPHLKYVEKRDGITYNKNTGLKGEIASFARSQLEGDVLRTSEAGKFIERIIVPVSRHAQMAAELTRPDNGYLVDDGVVPLVEEDRMKPVYQKELHGVDFVIQAIGFVRNKLPELRLPVEAGLNNVPYVSNPKHLMFDSVTGTIFHGERDSREKSAPIGLYGAGSAFPELERTSPGLPREPAVSMAKFMKYLECNAPEWIFELRQAERWHHRMRERKVWKAVARGWYKQDSRERRILQRMHEGEILRKELGEPKWYTEWKASRRSRLTPRQLRMLQIRQSKLDVWYRRQRWYSYRDIDWRRRTRWAAEYALRPGYTKFYRQAEPVEVIKSKQMTPEMLKRRRERWARKRLRWKQLRRLKTLEAKKRKEEDERRSLRELFILQDEQEQKAKETAQQVGQQANNTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0S079</accession>
    <name>G0S079_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S acidic ribosomal protein P2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0009060</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">P1 and P2 exist as dimers at the large ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691431.1">
        <property type="nucleotide sequence ID" value="XM_006691368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S079"/>
    <dbReference type="STRING" id="759272.G0S079"/>
    <dbReference type="GeneID" id="18254944"/>
    <dbReference type="KEGG" id="cthr:CTHT_0009060"/>
    <dbReference type="eggNOG" id="KOG3449">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114656_0_2_1"/>
    <dbReference type="OMA" id="MKVIASY"/>
    <dbReference type="OrthoDB" id="1227494at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002182">
        <property type="term" value="P:cytoplasmic translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05833">
        <property type="entry name" value="Ribosomal_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044076">
        <property type="entry name" value="Ribosomal_P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="81"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS23240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="112" mass="11298" checksum="6ABCF6358BA6BEF9" modified="2011-10-19" version="1">MKHLAAYLLLGLGGNASPSAADIKAVLESVGIEADNERLEKLLSELQGKDINQLIAEGSSKLASVPSGGAAVAAAAGGAAAGGAAAEAPKEEEKKEEEKEESDEDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0D2</accession>
    <name>G0S0D2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Gluconokinase</fullName>
            <ecNumber evidence="3 9">2.7.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0009600</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>D-gluconate + ATP = 6-phospho-D-gluconate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate acid metabolism; D-gluconate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the gluconokinase GntK/GntV family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.12" evidence="3 9"/>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691484.1">
        <property type="nucleotide sequence ID" value="XM_006691421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0D2"/>
    <dbReference type="STRING" id="759272.G0S0D2"/>
    <dbReference type="GeneID" id="18254998"/>
    <dbReference type="KEGG" id="cthr:CTHT_0009600"/>
    <dbReference type="eggNOG" id="KOG3354">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077168_0_0_1"/>
    <dbReference type="OMA" id="HFIYLRA"/>
    <dbReference type="OrthoDB" id="275177at2759"/>
    <dbReference type="UniPathway" id="UPA00792"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046316">
        <property type="term" value="F:gluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02021">
        <property type="entry name" value="GntK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001607">
        <property type="entry name" value="Gluconokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006001">
        <property type="entry name" value="Therm_gnt_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01313">
        <property type="entry name" value="therm_gnt_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442:SF3">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13238">
        <property type="entry name" value="AAA_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS23293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="244" mass="26762" checksum="3AC990A0A4553411" modified="2011-10-19" version="1">MLSYNTSVSVNGQQPPSSGGISASRQSIPSSAQLGRLSAPGLANSACASSANSSNAMAAKGHHIWLVTGPAGCGKSTVAKYLSDVLHLPYIEGDEYHPQSNIEKMSAGIPLTDEDRWDWLTALREASIRELNRGNEGVVLTCSALKRKYRDVIRVAPYFTPNLYLHFIYLDAPEELLVQRVRARQNHYMGANMVHSQFEALERPRPDEVDVITINVNKPLEDVTAEALDRVLQTMAAHQQPPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0N8</accession>
    <name>G0S0N8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0010690</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691590.1">
        <property type="nucleotide sequence ID" value="XM_006691527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0N8"/>
    <dbReference type="STRING" id="759272.G0S0N8"/>
    <dbReference type="GeneID" id="18255107"/>
    <dbReference type="KEGG" id="cthr:CTHT_0010690"/>
    <dbReference type="eggNOG" id="KOG2551">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051938_2_0_1"/>
    <dbReference type="OMA" id="CYSGFIA"/>
    <dbReference type="OrthoDB" id="2094269at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF6">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="3">
        <location>
            <begin position="36"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS22598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="300" mass="32588" checksum="34F832F76872128B" modified="2011-10-19" version="1">MGDAAQSSSGTNIPTGAAAEVRGTPKPKPTPPPKREVKILMLHGYTQSGPLFRAKTRALEKLLVKLLSPANIFPRLVYATAPNRLSAKDIPGFTPRSGEEEKEELEAWAWFRKDEATGRYRFVKEGMERVAEVISNPNGEFAVTGDGDPVPEGPFDGVVGFSQGGCAAGMVASVLEHISPDGKFRRAPEEHAEWAKKVREANGGTALKFAVIYSGFWAVPEDLGWLYEPKIRTPTMHFLGSLDTVVEHSRSEGLIERCEEPVVLTHPGGHYVPISKEWAVPLAGFIRKCVDGEGNGKASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0S118</accession>
    <name>G0S118_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ML-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0012020</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691720.1">
        <property type="nucleotide sequence ID" value="XM_006691657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S118"/>
    <dbReference type="STRING" id="759272.G0S118"/>
    <dbReference type="GeneID" id="18255240"/>
    <dbReference type="KEGG" id="cthr:CTHT_0012020"/>
    <dbReference type="eggNOG" id="ENOG502R5MY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009253_0_0_1"/>
    <dbReference type="OMA" id="GCFQAVM"/>
    <dbReference type="OrthoDB" id="5377623at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF7">
        <property type="entry name" value="TRP-LIKE ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14558">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408719" description="ML-like domain-containing protein" evidence="9">
        <location>
            <begin position="27"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="509"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="539"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="571"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="ML-like" evidence="10">
        <location>
            <begin position="38"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="632"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="797"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="797"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="818"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS22728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="884" mass="97563" checksum="EF9C1EAF6EE765CB" modified="2011-10-19" version="1">MTRAAWPRSRPSAFLLLPFLLSVGNCYYTSKPAPSPTPALYTGQWGECADENVLSVERFGASYDSVNKTLSFGFEGSPGVEKNTSVLLQFSLEAYGTNRINLTIDPCSYNVTSLCPLNPKLPIAAAALLPVSSQTIGDLPSSDLTYPNFEGSLTLRVYTKKTKSELSCYRATITNGRSFSHPEIIAPILAAFTVAAILSSFFSAAYGVSIPHMRDAAAEVVRLGGGQVVRILARGEAGTVTEEEEVEPYVYNYTYSAGHIVPGVPLPATRMGFAATLAEHRVPVADVFILSLIWFLVAVGAVIMAIGGLKVFLEGLGKAKKIKEDRLAYFRSHWLGYLGHALMRTLVAAFFVVLTLAMYQFTMRISTGAVAVAAVMFIVMVCVLSLPVAFVCLLRVRGGKIVVGKDKVVFYYACVLQVLPWVFCIRESTIKQHALEVRQLFSIPFFRVQHIDSKPERLTVHTDQTLIKRFGWITARYRRSRWWYLVLHIAYQFCRAAFLGGGWQNPHAQIYGLLVIDCLAFATGVFLRPFESTRNNVMAVWVLGLNKIITTAISIRFLPGNNLDRKAAARLGLAIIIIQALTVVTLLILIVLSCLSTWLSLMRNREEMDPDWLEPTRARYFYDIEEKAQDSSEPWKRPGVKCLNPKEPTPPPTPRFSVNMVRRNPKIEDEDEDAPPSPSKLVINRTDDACSNTEEGDHLDPDNDLPTGARSGRHSRTSSVHSRYSVGSLPRGARPYRASWSSRDFGDPAAQRPDSTLAQRLSGLTFIIDHISDGDGAAPNAGASLATLTMTSGGNSALSLNTNTPSVSRASTPSLGRSSREFNGRSSREFSFRELFHSDAGRRSSREFRESRESRESREMHSDANAGRRPPTALPEAPEPPEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0S123</accession>
    <name>G0S123_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0012080</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GDT1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EGS22733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_006691662.1"/>
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    <dbReference type="KEGG" id="cthr:CTHT_0012080"/>
    <dbReference type="eggNOG" id="KOG2881">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OMA" id="YWWVTIG"/>
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    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0015085">
        <property type="term" value="F:calcium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:Golgi calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032472">
        <property type="term" value="P:Golgi calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="InterPro" id="IPR001727">
        <property type="entry name" value="GDT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049555">
        <property type="entry name" value="GDT1-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN HTP-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01169">
        <property type="entry name" value="GDT1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="UPF0016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408726" description="Transmembrane protein" evidence="9">
        <location>
            <begin position="24"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="478"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="107"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="364"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="151"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS22733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="501" mass="53267" checksum="66A51D2DDAC37A1B" modified="2011-10-19" version="1">MKLKTSQSSVIFLLLPSLAITAAVSDAPLSKDTVSTTDILASGRGLGTKDAPIDGKDGRPHAGPFVELNVPSSKADELPPLPSRPADPTIVDGKKIPDIHDGVMVDKAHAGPKKGTTGLEGGVTEKSREKILREQQGEIVENKPQTPKEAPPLEHSDHEKIAGGKGSKTTDKSSERTVEDVLGLEKPADLPEKTHDKSLPVPESVADIDHLAVSDTVKSGSPLLDNGENEGLIRPFHSFILSLTMIIFSEVGDKTFLVAALMAMKHDRLVVFSGALGALVTMTVLSAVLGHAVPTLISKRLTNFLAAGLFLVFGARLLREGLAMSPDEGVSAEMQEVEMELEEKENLARKKSDVSPYALEMGLGNRKSRSKSRFPAPARSPSSSPEGRSSSPRPSVLANFLSGLNNLLSFLLSPAWVQTFVMTFLGEWGDRSQIATIAMAAGQDYWWVTLGAIMGHACCTGVAVIGGRAIAGKVSLKVVTVGGAIAFLFFGVIYLFEAFYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0S190</accession>
    <name>G0S190_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">2-dehydropantoate 2-reductase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0012750</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006691729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S190"/>
    <dbReference type="STRING" id="759272.G0S190"/>
    <dbReference type="GeneID" id="18255313"/>
    <dbReference type="KEGG" id="cthr:CTHT_0012750"/>
    <dbReference type="eggNOG" id="ENOG502QT3Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021479_0_0_1"/>
    <dbReference type="OMA" id="VHENSYS"/>
    <dbReference type="OrthoDB" id="5302359at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000424">
        <property type="entry name" value="Meiotically up-regulated gene 72 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF25">
        <property type="entry name" value="PROTEIN PAM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="2">
        <location>
            <begin position="9"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="3">
        <location>
            <begin position="197"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="452"/>
        </location>
    </feature>
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        <location>
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            <end position="572"/>
        </location>
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            <end position="715"/>
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            <begin position="334"/>
            <end position="346"/>
        </location>
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        <location>
            <begin position="356"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="509"/>
        </location>
    </feature>
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        <location>
            <begin position="555"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="659"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="700"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS22800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="715" mass="78123" checksum="2190CEAE394E7B30" modified="2011-10-19" version="1">MAPRLKFLSVGGNPVSAFLSWRLQATNACDVTLVWKAGYEHVAQYGISFKSPVYGNERFKPRHVVRTPEEAAARKDSAYDYVILCIKALPDIYDLASVIDSVVTPQHTCIIVNTTQALGLESAIEERFPTNVVLSLVCGAEIAQLGASEFEHKRSTELWVGAANKNANIPASIQEDMAQALAMTLSTGQVDCKVSPNIRQQQFERVIGPIAFNPLTVLFETPNYAALLDKVGVSKLVSDVIDELLALATAYGCKFPAEFKKNTIDEFARLNTENIMWQDYNARRPMEVETYLGSPIKLAKDVGVTVPRIETLYAILHNLNLVNRSRPKADVTEPPSGQPGSPSGAPTPVPRMSAQGMSMPNSMPNGNGMPPGRPRPRGPMGPPGPGMRRPPPSMNGGPNGYSRPPTGMGSRNPSRRGSMDGGDLEEFRDLVLYDDIPESGEAGGYPQQQLTPQELAIRERELQLRQRELALREQEMRLRRAAAGMGPGPRRPPPRGNMYDDDDEDDYVDPNDLPPAPMIDPDNFDMMSVTSRKNRRVPSSPAQFRKNPEEEINKSRSRFRPSFGRHRSSGASQQIMNTIPGLHQDIMDDPLLGFTSNRYGNVDRGAIHQAVGSRANSLTAARLDDMQYGLNGNGPRRSSQSPGNPYSPPITGGPIGGRPSPPGQVGPPQPMNGRPSPPDSVRQPMPRYPPGQGNMVAPQQVEQYAGSNGVLEQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1J6</accession>
    <name>G0S1J6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Stc1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0013840</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691898.1">
        <property type="nucleotide sequence ID" value="XM_006691835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1J6"/>
    <dbReference type="GeneID" id="18255422"/>
    <dbReference type="KEGG" id="cthr:CTHT_0013840"/>
    <dbReference type="HOGENOM" id="CLU_444098_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024630">
        <property type="entry name" value="Stc1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12898">
        <property type="entry name" value="Stc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stc1" evidence="2">
        <location>
            <begin position="17"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="351"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="436"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="475"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="558"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="615" mass="68388" checksum="A0CFCA6DEF3723BA" modified="2011-10-19" version="1">MARTGFIGKAAESKVVRCVGGNHWVYLTELSHSQRQKYHNLKNAGRATPCNAQICCPEHVDMVDGNGNIRPKDGVECDICQRVLPPDAFSKSTFRSGQPICKGCRSDTQIPLEAAAVVADHDERMTEEQFYYRNRFILGSNEVYEFEDEDVVPTLPKLPFSHPKYFRRSENSLQDASWEETDNSNSLGASSSSSGTDLSSLCSPANGEAEAEFNLASFKVDLDQFIPEHLRNVAEEPYTPPHWLLPSEFFQVTTVTKRTEICYRVNPCFAGFANGPNGTQIGVNEVNDDDWESLPAPDSTLNDKDGGWDEDYYNVADSWDAPNNAVDSWDTPHNAAGSLDMPNNAADSWDAPNNAPTNNNTSNSASNNNNVYGENHNYNSRRGNSHRRNNSHRRDESSNQNVPALIADQAAERPEETNTRPSGKSHTTQNSDNSATNVVTGTTGTKTPYNRNMNRGVETRHFRHNHYFAPGRQYNNNGHVNKNHGNNGKHTSKGNRSGNNGDSNRHDGNGNHPDNNNGHRANSSNNNNRFGNHHRNNSNIGQNSFQQGEKWHNSNRQSNGNSNAHSSNNYFCNSNGSSGSRRNNRWEKDPAGTRKTAHILPFFASYRDPGSMARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1X0</accession>
    <name>G0S1X0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">holo-[acyl-carrier-protein] synthase</fullName>
            <ecNumber evidence="1">2.7.8.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0015130</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.8.7" evidence="1"/>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS23030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692022.1">
        <property type="nucleotide sequence ID" value="XM_006691959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1X0"/>
    <dbReference type="STRING" id="759272.G0S1X0"/>
    <dbReference type="GeneID" id="18255551"/>
    <dbReference type="KEGG" id="cthr:CTHT_0015130"/>
    <dbReference type="eggNOG" id="ENOG502SA2B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031126_0_0_1"/>
    <dbReference type="OMA" id="HRTCRIP"/>
    <dbReference type="OrthoDB" id="26719at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050559">
        <property type="entry name" value="P-Pant_transferase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215:SF10">
        <property type="entry name" value="L-AMINOADIPATE-SEMIALDEHYDE DEHYDROGENASE-PHOSPHOPANTETHEINYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215">
        <property type="entry name" value="PHOSPHOPANTETHEINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="4'-phosphopantetheinyl transferase" evidence="5">
        <location>
            <begin position="224"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="157"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS23030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="363" mass="40571" checksum="4FB39DC43D3B7858" modified="2011-10-19" version="1">MALASSLLKHYAIARLSTMISDSGSDKSVGDSGHGQGGIPWDRTIITRDSLTKPVFVDPRTGRQPVSFNVSHQAGIVALVAVAGYEAPPNPVDANAPPSTPARGQRRQKVPVEVGVDVVCVSERRERDLAMLWDESEGWEGFVDMHADVFSPSEVAYLKGSSPPAPRPPPGPASAARRSRSRSSRGSEQYYQQSPEQQRYVRELSPEKQRHYLQHLEDLRRRAEEEEDEIEEGMADGKLRMFYALWALREAYVKLTGEALLAEWLSELEFRDFRAPKPTAAWEVPACEERGEVVRDIEIYFRGQRVDDVNMCIRSMGPDYMIATAVRTPGRKEDGLAWQLGPYEILSLEDVLDFAAKSRLGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2A2</accession>
    <name>G0S2A2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0016510</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692154.1">
        <property type="nucleotide sequence ID" value="XM_006692091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2A2"/>
    <dbReference type="STRING" id="759272.G0S2A2"/>
    <dbReference type="GeneID" id="18255689"/>
    <dbReference type="KEGG" id="cthr:CTHT_0016510"/>
    <dbReference type="eggNOG" id="ENOG502SR1A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041686_0_0_1"/>
    <dbReference type="OMA" id="WAIEIME"/>
    <dbReference type="OrthoDB" id="4186058at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="377" mass="42041" checksum="72A73AF928B56045" modified="2011-10-19" version="1">MWPTPTDIKISQSVGPSSPPETPRTASPVFGRKSSPPRGQSHTQGTIPRPMAPPLSTGQPSAVNTRFSFSHSQALRPDQLSPRTTGSSSPSSSASDDSEDSDFDAPSPVRLPSLPDPPSPKERIGRVVTHHEFTVEELSDSGELNGKYAHLHVIRAYTIEYAESERSRSRSRPPAGLDQGMMRNFTNLNCSDSSSDESDMDDGEVQAMLRRYRAERRQRRMTSGSVSKRTISESIGSDTDREDLVGSFSFEDVNSTRRIRRKLCGDRRRGSFLFPTPPAPRIDELEEPDSSVEEITIGEVLARELPYYDHSCGEDHYTTSFFAAYDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2I6</accession>
    <name>G0S2I6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="17">5'-&gt;3' double-stranded DNA exonuclease-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CTHT_0017360</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692238.1">
        <property type="nucleotide sequence ID" value="XM_006692175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2I6"/>
    <dbReference type="STRING" id="759272.G0S2I6"/>
    <dbReference type="GeneID" id="18255774"/>
    <dbReference type="KEGG" id="cthr:CTHT_0017360"/>
    <dbReference type="eggNOG" id="KOG2518">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008978_2_1_1"/>
    <dbReference type="OMA" id="CGSEDQI"/>
    <dbReference type="OrthoDB" id="26491at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09908">
        <property type="entry name" value="H3TH_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09857">
        <property type="entry name" value="PIN_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000011">
        <property type="entry name" value="exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000002">
        <property type="entry name" value="Exonuclease 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037315">
        <property type="entry name" value="EXO1_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044752">
        <property type="entry name" value="PIN-like_EXO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF65">
        <property type="entry name" value="DNA DAMAGE-INDUCIBLE PROTEIN DIN7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="8 17" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="16">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="15">
        <location>
            <begin position="138"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="410"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="528"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="704"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="477"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="528"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="583"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="638"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGS22219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="743" mass="83300" checksum="718EFEDFC52A858D" modified="2011-10-19" version="1">MGIQGLLPLLKSIQRPTELKRYAGETLGVDGYGWLHRGAVACAIELAQGKPTRKYVDFAMHRVKMFRYFGVTPYIVFDGDFLPSKAKTEESRKKRREEAKKVGLELLRAGKPSLAFNELQKAIDVTPEMARHLIEELKKEDVPYVVAPYEADAQLVYLERKGIISGIVSEDSDLLVFGAKRLLTKLDQHGQCVEINRKDFCLVREISLTGWTDSEFRHMAIFSGCDYLEGLSNIGLKTAYRLIRKHKTPDRIVKMLRFDGKYQVPQNYLEEFKQAELTFLHQRVFCPEKKDIVFLTEPDPSLNIDEMPYIGAPIETELARAIAVGDVNPITKQRILVPLSPQKRTISQALAPASAPRTLGKPIDQYFKERADYRRIPLGEMDPNCFQVDPNREPTDVPRPIVFPLPRPYVEGAEEPASPTTRNYVNAGRTLRRRSEPISKLLDRMDPESSHRRQTVGPSFQVYRDPTASTTPPKKARLCEEVELPEDRSATTLEKSKFFPSKKEKQPAQPKDDFILRSDDSFEEALRTLPEHDAGDPKEKPAAKEIAIFEEQPPSKKDLASALESQEQTVDDAILMPASSPIQQRAAQDSQDSQASATPLADALRSFSYEAGRPQTRIVRGLPTPASSMPSGTPKIASPTSSQTPLPTPLQRIGARALQRSKPSKPPVPLRKPVSNNSTDNLVNPAMIPLPRVDLAEIEALNRPLGSEDQLLIPASDDEDDGDKRPTAVPSARRLDLSRFRYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2M3</accession>
    <name>G0S2M3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">2-(3-amino-3-carboxypropyl)histidine synthase subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0017750</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the DPH1/DPH2 family. DPH2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692275.1">
        <property type="nucleotide sequence ID" value="XM_006692212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2M3"/>
    <dbReference type="STRING" id="759272.G0S2M3"/>
    <dbReference type="GeneID" id="18255813"/>
    <dbReference type="KEGG" id="cthr:CTHT_0017750"/>
    <dbReference type="eggNOG" id="KOG2648">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015210_1_1_1"/>
    <dbReference type="OMA" id="QIWNENH"/>
    <dbReference type="OrthoDB" id="449241at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000002">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010014">
        <property type="entry name" value="DHP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00272">
        <property type="entry name" value="DPH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF2">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01121">
        <property type="entry name" value="Diphthamide_biosynthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00408">
        <property type="entry name" value="Diphthamide_biosynthesis_famil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="409"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="454"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="513"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="454"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS22256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="546" mass="59103" checksum="02AC692A2014AA28" modified="2011-10-19" version="1">MTAGELSVAPILSTPAENLFEYSVATAENDAQIPPRSDDELCDIYEIARTAKEIREGKWRRIALQFPDSMLKDAPRVAQLLGQELASLPKPADHDQSIPPERIHILADTSYSSCCVDEIAAEHVHADVVVHYGRSCLSPTCRLPVIYVFTHHQLDHDQVLSAFELQYPDKEACVVLMADVTYQDHVPSLAAALHARGYINLLSTAIIHDPTGTIPNRKLVSPDPSGDSNALAQPTVNLQSYSVFHISSPPTALLLALSSRVQSLHIYPTSTSTSTISPDAAPRLLGRRYARVLTLASAGVIGILVNTLSVANYLTAVDKIRKQIAAAGKKSYTVVVGKLNAAKLANFAEIEGWVVIGCWESALVEEDGPMGASGGLFTPVVTPFELEVALTPDDKRVWGGEWWGGIEKLGKAESENDSVEDGQADKVDEDEDESVPPEFDLRTGKLITTSRPMREKTVKSAKGIREQSVEEGSQIGGSSSALTLRAKGDVTRVNGVISPGAEYLRSQRTWQGLGSDFTPDEESTVVEEGRSGVARGYTVGPNKERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2Q7</accession>
    <name>G0S2Q7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0018110</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692309.1">
        <property type="nucleotide sequence ID" value="XM_006692246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2Q7"/>
    <dbReference type="GeneID" id="18255849"/>
    <dbReference type="KEGG" id="cthr:CTHT_0018110"/>
    <dbReference type="HOGENOM" id="CLU_1855049_0_0_1"/>
    <dbReference type="OrthoDB" id="4842715at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS22290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="138" mass="16013" checksum="74CAE5FE428F1951" modified="2011-10-19" version="1">MAHHASLRVNQLCTKARGLGLRVDPSKTEVHYIPPPRRRHRSEAWQDGHDNNLDPDGEDVLPPWAAVDGRLVPSRFTPVWSSLIKVAYAALRVIFPVWRTIPTAWLWWLAGLYPEYLLDRERARWRARVEMLPANHPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2U6</accession>
    <name>G0S2U6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prefoldin subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0018530</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692348.1">
        <property type="nucleotide sequence ID" value="XM_006692285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2U6"/>
    <dbReference type="STRING" id="759272.G0S2U6"/>
    <dbReference type="GeneID" id="18255891"/>
    <dbReference type="KEGG" id="cthr:CTHT_0018530"/>
    <dbReference type="eggNOG" id="KOG3478">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125172_2_0_1"/>
    <dbReference type="OMA" id="VQTEFAQ"/>
    <dbReference type="OrthoDB" id="248120at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23161">
        <property type="entry name" value="Prefoldin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000003">
        <property type="entry name" value="Prefoldin subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS22329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="13177" checksum="14B9C75B4541AF89" modified="2011-10-19" version="1">MAEIQARLQALSEEFSKLQQDALQSRQKLEAQKQENLGEFTKLKEGENIYKLIGPVLLKQDKADAESTVNGRLDFINKEINRVETLIKELQGKVEKKKGEIIQVQSGLQAAAAQAVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3K2</accession>
    <name>G0S3K2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0021550</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692625.1">
        <property type="nucleotide sequence ID" value="XM_006692562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3K2"/>
    <dbReference type="GeneID" id="18256193"/>
    <dbReference type="KEGG" id="cthr:CTHT_0021550"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1234864_0_0_1"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS20329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="224" mass="24637" checksum="C2F4BEEF460DECD0" modified="2011-10-19" version="1">MADWVAQVAGAQYNDTIELFTIPCDSGKDNKARFSFQLEGPEGPWIHAEVLDLIVAASDVRTLYTDIGHGWVVFTEELAGNNICLLGVQKPNSYQSFQSIGSSLLRRTYLVFDNVNEEVAMAPVKFPTDSKPPKPNIVYFKKYGSKIPSSALYCEISKPLCEYDGYNFSNTGHKVGIAAGVVGGVLVLAGFAAGIWWHRRKTKKGQETEKWKVGRGPSVVGRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3Q4</accession>
    <name>G0S3Q4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 18">3-isopropylmalate dehydratase</fullName>
            <ecNumber evidence="6 18">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 18">Alpha-IPM isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 18">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CTHT_0030240</name>
    </gene>
    <organism evidence="23">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 18">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 18">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="6 18"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693476.1">
        <property type="nucleotide sequence ID" value="XM_006693413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3Q4"/>
    <dbReference type="STRING" id="759272.G0S3Q4"/>
    <dbReference type="GeneID" id="18257062"/>
    <dbReference type="KEGG" id="cthr:CTHT_0030240"/>
    <dbReference type="eggNOG" id="KOG0454">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006714_0_0_1"/>
    <dbReference type="OMA" id="EDNEPHT"/>
    <dbReference type="OrthoDB" id="2279155at2759"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009316">
        <property type="term" value="C:3-isopropylmalate dehydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydratase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000007">
        <property type="entry name" value="3-isopropylmalate dehydratase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000003">
        <property type="entry name" value="3-isopropylmalate dehydratase small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01026">
        <property type="entry name" value="LeuC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01031">
        <property type="entry name" value="LeuD_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004430">
        <property type="entry name" value="3-IsopropMal_deHydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004431">
        <property type="entry name" value="3-IsopropMal_deHydase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012235">
        <property type="entry name" value="3-IsopropMal_deHydtase_ssu/lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00170">
        <property type="entry name" value="leuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00171">
        <property type="entry name" value="leuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002458">
        <property type="entry name" value="PRK01641.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004016">
        <property type="entry name" value="PRK05478.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009116">
        <property type="entry name" value="PRK12466.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF9">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001418">
        <property type="entry name" value="ACN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10 18" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 18" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="14 18" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="20">
        <location>
            <begin position="13"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="21">
        <location>
            <begin position="546"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="514"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00033368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR001418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EGS21180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="783" mass="85543" checksum="515FB907AE4F172A" modified="2011-10-19" version="1">MPAAERTPQTLYDKVFQAHIVDEKLDGTILLYIDRHLVHEVTSPQAFEGLEVAGRKVRRPDCTLATTDHNVPTTSRKTLKDIASFIQEEDSRTQCVTLEENVKKFGITYFGLSDKRQGIVHVIGPEQGFTLPGTTVVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTLITKRSKNMRIQVDGELAPGVSSKDVILHVIGKIGTAGGTGAVIEFCGSVIRDLSMEARMSICNMSIEAGARAGMVAPDEKTFEYLKGRPLAPKYGSEEWNRAVAYWSTLKSDPDAKYDIDVFIDAKDIVPTVTWGTSPEDVVPITGCVPDPESLPEGKRAAARRMLEYMGLQPGTPMEEIPIDKVFIGSCTNSRIEDLRAAAAVVKGRKVAPNVKRAMIVPGSGLVKEQAEREGLDKIFLDAGFEWREAGCSMCLGMNPDILSPKERCASTSNRNFEGRQGAQGRTHLMSPVMAAAAAIVGKLADVRKLAQFKGSPHIEAAIAPEPAAPAAEPAHADERIETDDAEKEHLADQPEDSSPQVNTTVLHNVGGAGGVPKFTILKGIAAPMERPNIDTDAIIPKQFLKTIKRTGLGSALFYEWRYLEPGVENPDFVLNKEPYRRAKIIVCTGPNFGCGSSREHAPWALNDFGVKCIIAPSFADIFFNNSFKNGMLPIAIKNQAELERIHAEAVAGREIEVDLPNQLIKDQDGNVLCAFDVEEFRKHCLVNGLDDIGLTMQLEDKIAEYERRMEREWPWLNGAGYLRRKGQGGKLAVKAVPVPKTNRGDVKTEPLEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3T9</accession>
    <name>G0S3T9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ARF GTPase activator-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0038820</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS22001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694297.1">
        <property type="nucleotide sequence ID" value="XM_006694234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3T9"/>
    <dbReference type="STRING" id="759272.G0S3T9"/>
    <dbReference type="GeneID" id="18257920"/>
    <dbReference type="KEGG" id="cthr:CTHT_0038820"/>
    <dbReference type="eggNOG" id="KOG0706">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023062_7_0_1"/>
    <dbReference type="OMA" id="PANQVCF"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08831">
        <property type="entry name" value="ArfGap_ArfGap2_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000013">
        <property type="entry name" value="Putative Arf GTPase-activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="11"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="145"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS22001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="494" mass="52706" checksum="E80BFAC60166C313" modified="2011-10-19" version="1">MSGLASKQESLKIFEKLKSKPANKARVCFDCGQKNPTWTSVPFGIYLCLDCSANHRNLGVHISFVRSTNLDQWQWDQLRIMKVGGNESATKFFQANGGSAALNSKDPKTKYTSPVAVKYKEELKKRAARDAKEYPNEVVITDHDVADGSSTPAEEEDDFFSSWSRPAVKKPTPPVSRTATPPVVGRTPSPFLSAQNGKDRAPSPLAKSASSEAGEGSMPAAKPAARVTSTSTLRSSATGPRKTNILGAKKATSHKLGAKKLGAGDAVIDFEEAEKKAKEEAERKEKLGYDPDAEEEEVVTKTGAKAEGSGAIIEPTPVTSVRAGFGATSAAAKDKKDVERLGMGIARLGFGQVSRPDAKKGAGGFGSVGPIKGKPEDEEETYARRKFGNQKAISSDEFFGKGMFDAQAQAEAKERLRGFEGASAISSNAYFGRPESEDDPASAALDDYGDLETAAKDFIRRFGLQAGDDLEQLTHLLGEGAGRLQGAIRAYLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3U6</accession>
    <name>G0S3U6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0038930</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS22008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694304.1">
        <property type="nucleotide sequence ID" value="XM_006694241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3U6"/>
    <dbReference type="GeneID" id="18257931"/>
    <dbReference type="KEGG" id="cthr:CTHT_0038930"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_34_23_1"/>
    <dbReference type="OMA" id="SEECTHW"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="80"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="3">
        <location>
            <begin position="385"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS22008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="490" mass="55612" checksum="21C6AC1803C4CD32" modified="2011-10-19" version="1">MSNIGSAAVHNSNPLTVNNADSPASDNTDTESVISSDQSQVSSDWEEELEDTEILDWLSSLSKEDFSKKQADFLRQRQEGTGQWFLESPQFQEWYSPCFLRTWLILIFPQANQPTRLSRKSVTLFCPGIPGAGKTILASIVIDHLQRNLTNRDVGIAYLYCNFRRVGDQTVEQLLANLVKQLIMNKSPPPRAVVKVYSERNKYQSEPSLNDLEKMFRTVAALYKDGVFVIVDALDECQMSDDVRSKFIEALLRLQSKRSNVNILATSRPVPDIVEAFDGHSTRLEIVAHRDDIERYVRNQMSNLRTVSKYPDLQHEIVSCIANVADGMFLLAHLFVESLKDKVSAKLIRKTLNELQNDSKEKEPRLALLRRAYDNVMKRINGQPVGYKELAKHVLSWIVCAKRPLKTTDVQYAWAVKDSEDELDETAIPDAEDMLSACCGLVVIDKDSEIIRLAHYTAQEYFQDTWIGAYGLNDLAKALLTDQAMEAIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G0S424</accession>
    <name>G0S424_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">dual-specificity kinase</fullName>
            <ecNumber evidence="1">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0022290</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="1"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692696.1">
        <property type="nucleotide sequence ID" value="XM_006692633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S424"/>
    <dbReference type="STRING" id="759272.G0S424"/>
    <dbReference type="GeneID" id="18256267"/>
    <dbReference type="KEGG" id="cthr:CTHT_0022290"/>
    <dbReference type="eggNOG" id="KOG0671">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_5_12_1"/>
    <dbReference type="OMA" id="SINPQHY"/>
    <dbReference type="OrthoDB" id="283111at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14134">
        <property type="entry name" value="PKc_CLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000612">
        <property type="entry name" value="Serine/threonine-protein kinase AFC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="353"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="107"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="168"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="692"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="171"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="692"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="716"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS20400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="744" mass="84672" checksum="3A960F7EA0BF5B58" modified="2011-10-19" version="1">MSTPTTATATLPHYNPHHLRYSHHQHHQQYASTNQPNSSAYRTATVLPPASQLSYPSATTAYPPATASTTNGLAPVSASDLTRVLPHHTADVTTSRSDHYYTANMSAGSQHHHHHHHHHHHLLQQQQQPVAEQPQPARKRRRSRGPDWAEFYKNGLPKEIIVIEDTPEPQQPQQQPQTNNHITTSSQVTAASSSQVVATNGVNGSGKKRKRDDEHMPYDPVHHSAAIGSYTPSKSTVASDRTTTTYQTTAPTSLGSLSSNGQYEYDAQASQKRKRTTRQQVANEARRREVPPPLPPPMTDAFLSYKPPPFPPKKAKEVHIPVIPDTSPNKNVRYDDDDGHYIVVPEADLTDRYTIHKLLGQGTFGKVVQARDKVTNKFVAIKIIRSVQKYREASKIELRVLETLRANDAENRNRCIHFRDCFDFRGHICIVMDLLGQSVFDFLKSNNFVPFPNSQIQNFARQLLTSVAFLHDLNLIHTDLKPENILLCNSEYQTFTYNRKIPSASTTVCRQATQRKVLLDTEIRLIDFGSATFQDEYHSSVVSTRHYRAPEIILGLGWSFPCDIWSIGCILVEFFTGDALFQTHDNLEHLAMMESVVGQRIDVPLIQQVHRMTRNGGNSAAKYFKRYKLDYPQPDTTRASRRFVKAMKRLDEIVPPTTRFLAQFLDLLQKIFVYDPARRITAKEALQHPWFRESAHPDDGTEAARIRLERQRQREQQQQQQQQQQQQQANAHRPSCEVQPSIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>G0S452</accession>
    <name>G0S452_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0030730</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693522.1">
        <property type="nucleotide sequence ID" value="XM_006693459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S452"/>
    <dbReference type="GeneID" id="18257111"/>
    <dbReference type="KEGG" id="cthr:CTHT_0030730"/>
    <dbReference type="HOGENOM" id="CLU_900164_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="309" mass="31892" checksum="EACBE94148092208" modified="2011-10-19" version="1">MAENQGPPVTAATSVTEIPAPDPPSTHQPTQLDKADESHEQAAASSLVKEGAAALGDAATTATAADVARKDAGNTVKDAELTGSGPAGDAAQKEDKEKPPTENAPSAEQPGPVAPTPRQAKKSAEGEGEEGDTEMKDICGETKESAPVLAASGVKTEGEEVKEGQTEAEEKAKALVGKRTAEEAFDRARDSAGESEEHKPEEKKVKVYTGEGVSAWKGLQAEGEGETKDGGGKLEVEKTELVPKYSQGEAEAKTSKQEIAGQEGACQHTNGGSSSSPKKPGRPRKQSHLGKAPVGRTARKTRSQGPVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0S457</accession>
    <name>G0S457_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0030780</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693527.1">
        <property type="nucleotide sequence ID" value="XM_006693464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S457"/>
    <dbReference type="GeneID" id="18257116"/>
    <dbReference type="KEGG" id="cthr:CTHT_0030780"/>
    <dbReference type="eggNOG" id="ENOG502S0M4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_298777_0_0_1"/>
    <dbReference type="OrthoDB" id="4762260at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408882" evidence="2">
        <location>
            <begin position="19"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="617"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="668"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS21231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="861" mass="90709" checksum="2A22E28F548FDDE7" modified="2011-10-19" version="1">MVGSALALSLIGLGAVNALPTGKPAARRQWLGDGSTVFIPGNEAELPPCLTEVPLKQQPPCLLPPVVGGLEPSNRKRDAKSSRRSEKRGFWIGDPSSEFIPGNEEQLPTCLTDVPLKQQPPCLLPPIVGPIEPSNKAKRQFWIGDGSSDFIPGNEEQLPTCLVDLPLNQQPPCLLPPIVGPIEPSNKAKRQVIIGDPSSVFIPGNEEELSPCLVDVPLQEQWPCLLAPIVGGIEPSNKAKRQFWIGDGSSEFIPGNEEKLPECLIGVPLKEQPPCLLPPIVGPIEPSSKTKRQFWIGDGSSDFIPGNEEKLPECLLDVPLKQQPPCLLPPIVGPIEPSPKAKRQILIGDGSSVFIPGQGDIPVCLVDVPLNEQPPCILPPIVGGLEPPTLLEPGKLPKRDTFALVDLDAVGTYKDECPDVEGAQLALKVLLEKEKLDVEELIIKKKLEAFLKGCGVSAIISPEGSWIFIKPADKRNLAVSSFDLTGLKAAFEALVSVASLNPNGLPSFNNWLVLQQIAAILDIYGSPVNSTFDVATKRDTNYSEVTKTVAVKSCSIGDIMGLRAALMALLAAYGNPAHAPPTVFLAEQVIVAALQVCGEAVQGWITLLPGAAQPGPIVPETPVPGGPIKPDPTVPGGPLEPENPIPGGELEPETPVPGGELEPEKPVPGGEITPENPIPGGEIEPEKPVPGGEITPENPIPGCELEPEKPIPGGEITPENPIPGGEITPENPIPGGEITPENPIPGGEITPENPIPGGEIIPENPIPGGEIIPENPIPGGELVPSTKAKRDVIVSVSNPEALLETLRILEQAYGGYGSGTIPVPVWLILVNIVSILQSIPGVIVPGWPVLGPGSVVLTPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0S484</accession>
    <name>G0S484_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tetratricopeptide repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0031070</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693554.1">
        <property type="nucleotide sequence ID" value="XM_006693491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S484"/>
    <dbReference type="STRING" id="759272.G0S484"/>
    <dbReference type="GeneID" id="18257145"/>
    <dbReference type="KEGG" id="cthr:CTHT_0031070"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002863_0_0_1"/>
    <dbReference type="OMA" id="PQACLYQ"/>
    <dbReference type="OrthoDB" id="411857at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031930">
        <property type="term" value="P:mitochondria-nucleus signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000266">
        <property type="entry name" value="Pentatricopeptide repeat domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001206">
        <property type="entry name" value="Pentatricopeptide repeat protein (AFU_orthologue AFUA_5G10660)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057585">
        <property type="entry name" value="TPR_dom_fungi"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47936:SF1">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN GUN1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47936">
        <property type="entry name" value="PPR_LONG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24603">
        <property type="entry name" value="TPR_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="408"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide repeat" evidence="7">
        <location>
            <begin position="526"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="899"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="934"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="970"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="1148"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="143"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="210"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS21258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1200" mass="132339" checksum="7F6FF1CE9C65416C" modified="2011-10-19" version="1">MPSVYSSIFQNFIRQGFAKSFTHGYAQSVVAATHPHVLNSQNRPSFARRHNAARVGRLGGFGLQSAFHSNALQTSGEQSKEKAAGHGHGGLDAYFEHLQKTQQSGEGDKDWVQFQFPKRIEWKPTPASVLRGSDAKTLALSKDTTLSTSKKDDKDASKAASEELAAKDDEVTTSPGVPPEAKEALAHIDAAIQKEIEVRKELEALEKEVESLRATSPELAEQLEEEIRSRSSLPGSRVRTPDSAARTATPIVDPQSQSYADHLTKLSEAGRYAEIPAVFEAMLVAGINPTPTAYNALLMAAIHLPSEKWEVVTKALDVYADMLRRKVYPDSDTYNILVGLLASRSLEVNSLKQALEDKRLRFGGMDEPGKFMFASHELEHAMLTEDDRLDLAIKLFRSSVQYNKARYSPETYHQLIAACAQCGRVDEMLQMFEHMELSETTPFAATFPAMITAFANSGDLISAVECYNEYRNLAIANDNGEKTLQDRLDAQVYAAVINAYIISDKLEGAKKFYEKILKEYGENATEIKDAIVAGGFVKGFIDRGIYREALVWAQEIEGEARAKAMAKIAAIAADRGDRQTAGAAFANILPASAVTTPAIALLAMHVREGDVVSATRYWDILCNPSLPPTADFIEPTAMYAVALIGSGQVLEGLTQADYMFQRIHVACAESRPQIVEEIEEGIEFIQRFMATRGIVDPRVTPLAPAPVMTPAMTPALTAETVPGSPVPNPEDSFDPYGSSTDFKGSVAIAEELDGTRGRKGSKLHDALARLRNMRRAGRHPRYFTYAKLITHAAKEGKLDICQEILAMARSDVPPLPQYAAVRYGWTSILDAMIGACLTLGQRTLAEQYHQELLAMGCTPSANTYGLYITTLKETTKTSDEASEAVKIFRRAKAEGVEPTSFLYNALIGKLGRARRIDDCLYYFAEMRRLGITPTSVTYGTVVNALCRVSDDKFAEELFDEMESMPNYKPRPAPYNSMIQFFLNSKRDKTKALEYYERLKAKGMEPTSHTYKLLIDVHATLEPIDMAAAEAVLETIRASGQQPEAVHYASLIHARGCVLHDMEGARRQFDAVINDPTIPPSVCLFQAILEAMVANHKVAETEPLLAQMRDKKLEMSAYIANTLIHGWAAEKNIEKAKEIYTTLGKDKREPSTYEAMTRAYLSVQDRESAKEVVSEMLTRGYPSAVVSKVLELLGGGERAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4M8</accession>
    <name>G0S4M8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit H</fullName>
            <shortName evidence="4">eIF3h</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0031570</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit H family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693599.1">
        <property type="nucleotide sequence ID" value="XM_006693536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4M8"/>
    <dbReference type="STRING" id="759272.G0S4M8"/>
    <dbReference type="GeneID" id="18257195"/>
    <dbReference type="KEGG" id="cthr:CTHT_0031570"/>
    <dbReference type="eggNOG" id="KOG1560">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_485703_0_0_1"/>
    <dbReference type="OMA" id="ANITHQN"/>
    <dbReference type="OrthoDB" id="10265695at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08065">
        <property type="entry name" value="MPN_eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000052">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03007">
        <property type="entry name" value="eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027524">
        <property type="entry name" value="eIF3h"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045810">
        <property type="entry name" value="eIF3h_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36986">
        <property type="entry name" value="UPF0643 PROTEIN PB2B2.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36986:SF1">
        <property type="entry name" value="UPF0643 PROTEIN PB2B2.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19445">
        <property type="entry name" value="eIF3h_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="5">
        <location>
            <begin position="215"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS21303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="561" mass="63008" checksum="974A0DCE6CFC6888" modified="2011-10-19" version="1">MGNLSVQTSSLRQQLAPGRHLVVSLYQDEEHLLDLESVGVEQQLMAIALTKLKCLRDDYATSPYLETFNWDEVIDTLRELTKESNHVWKETSFYIVAFRSQIPPTTAYEELSALDKAAHAEAIASGGFLKYWFGLPDAEGRNLATCIWRSHEDARKGGTGPAHRKAAGAARSFYASWKIDQDPKAYSRTPDSTIIKHTASDTMVESQKDAPFKTVQVEALVVMKIVKHCSSAFPTIATGSIVGMDNNGVLEITNAFPFPMIDVSSSDSHQDASSLAAAAPRAKANIAYQNEMIRHLKEVNVDANNVGWYTSATMGNFINLNFIENQYHYQRDNDKTVALVHDVSRSSQGTLSLRAFRLSPEFMAAYKEGKFTTDSLQKSKLSFRDILIEVPVIVHNSHLLTSFLHQIPAPPESAEIPLPASLDDIRRNPVKLPAHPSFDTLDLSIDPFLEKTCDLLLDSIESHYADLNNYQYYQRQLAREQFKISQWQAKRKAENAARLAAKQPPLPEDEWQRLFKLPQEPSRLEGMLNARQVEQYSRQVDGFTATITSKMFAVRGNLLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4R1</accession>
    <name>G0S4R1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0023220</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG101 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692786.1">
        <property type="nucleotide sequence ID" value="XM_006692723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4R1"/>
    <dbReference type="STRING" id="759272.G0S4R1"/>
    <dbReference type="GeneID" id="18256360"/>
    <dbReference type="KEGG" id="cthr:CTHT_0023220"/>
    <dbReference type="eggNOG" id="KOG4493">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069661_1_0_1"/>
    <dbReference type="OMA" id="VCWEIWT"/>
    <dbReference type="OrthoDB" id="10259639at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012445">
        <property type="entry name" value="ATG101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292:SF0">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07855">
        <property type="entry name" value="ATG101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="78"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS20490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="222" mass="25153" checksum="72538AFA0D86C3AC" modified="2011-10-19" version="1">MDQRGAPEFTLEAFADPSTVRDVVRGILHTIFFLRYFPSVLPKTRDVLGLELAYVPDEAIETLIDQRVNALRRAGIGVPRRGRRRRRRRRGGGGNIPSSGAGSSGSGRGQITVQFFEKRRRKTWYNIRGDDEVCWESWTIKVTVAEPRTEGERVKVRKASEATLHNTVMKAITLANSHKDHIPPITTTESNPFPYQIRIGAHPHQKDQQNAYSGWATRMGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4V8</accession>
    <name>G0S4V8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0031840</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693625.1">
        <property type="nucleotide sequence ID" value="XM_006693562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4V8"/>
    <dbReference type="STRING" id="759272.G0S4V8"/>
    <dbReference type="GeneID" id="18257222"/>
    <dbReference type="KEGG" id="cthr:CTHT_0031840"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_3_1_1"/>
    <dbReference type="OMA" id="CTHGFTH"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="161"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS21329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="387" mass="43365" checksum="127640C5BD4E5CF3" modified="2011-10-19" version="1">MKFDTPDRHGGDDSDSGRYLPIEAERELLATADTSFEVPSERPEETTSPIPPAPIITIDRYDWFSTSSESDSPMHVDETNDLRIKVSPLPSLQRLGHAFVVLTFRCFLLIPSCIIAFHNFYFRQRPDLIKQYSTCPGLHVRVFYPPSHEPGSSTGVRYPTLLTIHGGGFVFGKPRDNDSWNRRFANKHSILVIALDYRKAPKYCHPRPHTDIATLTEAVLKDDSLLIDRDRVAVAGWSAGGNLALGLTATPLLRFKVSAVVAFYPVVDFVPGKDMKARSRPYKAALGGFRGQERDYLYNLIDTFEWAYLGPGQSRTDPLLSPTHTDFHDLPKYVFTVGCELDMFAMEALKFMCKLSGREMPAVGNIVGRQEIGSEGELVTEGDERFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G0S561</accession>
    <name>G0S561_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="15">1.1.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CTHT_0032370</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="15"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693676.1">
        <property type="nucleotide sequence ID" value="XM_006693613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S561"/>
    <dbReference type="STRING" id="759272.G0S561"/>
    <dbReference type="GeneID" id="18257275"/>
    <dbReference type="KEGG" id="cthr:CTHT_0032370"/>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0538">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020639_1_1_1"/>
    <dbReference type="OMA" id="RIWFRPK"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000012">
        <property type="entry name" value="Mitochondrial cytochrome b2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF148">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (CYTOCHROME)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="5 17" id="KW-0349">Heme</keyword>
    <keyword evidence="10 17" id="KW-0408">Iron</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="19">
        <location>
            <begin position="104"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGS21380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="498" mass="55506" checksum="4B0DF03A676A8ABF" modified="2011-10-19" version="1">MAPLTGAEVAKHNRPDDCWVIVHGKAYDVTEFLPEHPGGAKIILKYAGKDATEEFDPIHPPDTLEKYLPKSKHMGPVDMSTVTKETVEVSAEEKERQKRIQEMPLLEQCYNLHDFEAVAKRVMKKTAWGYYSSAADDEITLRENHTAFQRIWFRPRILINVEKVDFSTTMLGTPVSIPFYVTATALGKLGHPEGEVVLTKAAHKHNVIQMIPTLASCSFDEIMDAAGPGQVQWFQLYVNKDREITKRIVQHAEARGCKGLFITVDAPQLGRREKDMRMKFTEEGSNVQKGQATDTSQGAARAISSFIDPSLSWADIPWFQSITKMPIVLKGVQRVEDVLKAIEYGVHGVVLSNHGGRQLDFSRSAIEVLAETMPILRERGLENKIEIYIDGGVRRATDILKALCLGARGVGIGRPFLYAMSSYGLAGVDRAMQLLKDEMEMNMRLIGANSIADLNPSMVDIRGLFSHSSPPVDNLFNSAYDPLVNPSQRTINVEKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5V9</accession>
    <name>G0S5V9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0033800</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693817.1">
        <property type="nucleotide sequence ID" value="XM_006693754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5V9"/>
    <dbReference type="GeneID" id="18257418"/>
    <dbReference type="KEGG" id="cthr:CTHT_0033800"/>
    <dbReference type="eggNOG" id="ENOG502T1ZY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1421273_0_0_1"/>
    <dbReference type="OMA" id="SNNPRIG"/>
    <dbReference type="OrthoDB" id="4590966at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="191" mass="21116" checksum="8423DB57E1210B79" modified="2011-10-19" version="1">MARNKNHRGVDATITAVPSSSPNGTTTTTTASTSKPLPNSPPVPPVPEVEVEPKRPGTSGTEAALTLSRRTASERLRQAQRAERTYKAKKRAAMARANRAEAAAHLRQAMQHFKLGVKLALAAVKGVPYILREKREVAKRRREEKERKKVEEKRRKLDEKLAAAEAALAESKSRKEKVQEEGTEGKEEDAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5X9</accession>
    <name>G0S5X9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 19">ATP-dependent DNA helicase II subunit 2</fullName>
            <ecNumber evidence="4 19">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CTHT_0025310</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 19">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the ku80 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4 19"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692991.1">
        <property type="nucleotide sequence ID" value="XM_006692928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5X9"/>
    <dbReference type="STRING" id="759272.G0S5X9"/>
    <dbReference type="GeneID" id="18256569"/>
    <dbReference type="KEGG" id="cthr:CTHT_0025310"/>
    <dbReference type="eggNOG" id="KOG2326">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010975_1_1_1"/>
    <dbReference type="OMA" id="WAMQYVW"/>
    <dbReference type="OrthoDB" id="30826at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00873">
        <property type="entry name" value="KU80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01458">
        <property type="entry name" value="vWA_ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000073">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.240">
        <property type="entry name" value="Ku, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024193">
        <property type="entry name" value="Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036494">
        <property type="entry name" value="Ku_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014893">
        <property type="entry name" value="Ku_PK_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF4">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08785">
        <property type="entry name" value="Ku_PK_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016570">
        <property type="entry name" value="Ku80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101420">
        <property type="entry name" value="C-terminal domain of Ku80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 19" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14 19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="15 19" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13 19" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 19" id="KW-0347">Helicase</keyword>
    <keyword evidence="9 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="VWFA" evidence="20">
        <location>
            <begin position="6"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR016570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EGS20695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="652" mass="72125" checksum="C35CF28D5439CEB5" modified="2011-10-19" version="1">MADKEATVYVIDLGESMSDCHNGREESDLDFAMRYVWDKISTTVSANRKTWTVGVVGFNTDDTDNPQDREGLEGYENISVLQEIGSMTMSSLRRLRSLIKPSHSSSGDAISAVVVALDMIEKFTKKLKYKRKIILVTNGHTPIDDDSTEDVALRLNQSSIELVVVGVDFDDPECTEGVFGTMAEAVEELAIPRIKPIRPYRSYEGLLTLGDPDQYESAISFHVERWTKTKVAIVPSASTVTVTHGPGGSSQTQTLDGEDVEMAGTELSNIKNTRTYFVKDPNAPGGKRDVPADEVERGYLYGETAVPFSESDYTVIKFDAKKSFTILGFIPFSSYQPFLSMGEAGCVVAQRNNPEAEIALSSFIHTLYELESYAVARFVQKDGAQPQILLLKPNPGIEDEFECLYDVPLPFAEDVRNFPFPPLDKVLTVTGNVLNEHRLLPSNDLRKAMSDFVDAMDLSKFDVDEEGNPAEYATLDDMYNPTIHLPPKAQGRRGKKETVKPLSGLDVDALLSDTGRSKRVPTISAENAIPEFKQALATAADDATIQSAAHQMGEIIRKLIADSFANLTYARAAECLRVMREELVALEEPRLYNKFIRGLKKSILSGELNGDRREMWAEHIAQAGLGLITNDESEVSDVTLQQASEFLRPSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0S628</accession>
    <name>G0S628_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mannan polymerase II complex ANP1 subunit-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0033960</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ANP1/MMN9/VAN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693832.1">
        <property type="nucleotide sequence ID" value="XM_006693769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S628"/>
    <dbReference type="STRING" id="759272.G0S628"/>
    <dbReference type="GeneID" id="18257434"/>
    <dbReference type="KEGG" id="cthr:CTHT_0033960"/>
    <dbReference type="eggNOG" id="ENOG502QVDT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_451968_0_0_1"/>
    <dbReference type="OrthoDB" id="204164at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000017">
        <property type="entry name" value="Mannan polymerase II complex ANP1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052086">
        <property type="entry name" value="Mannan_Polymerase_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083">
        <property type="entry name" value="MANNAN POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083:SF2">
        <property type="entry name" value="MANNAN POLYMERASE II COMPLEX ANP1 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03452">
        <property type="entry name" value="Anp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="539"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="539"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS21536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="604" mass="68706" checksum="B9AE82109D3180EF" modified="2011-10-19" version="1">MSADYPNAGYWRFTAQEILPSVTRDTRGPDEVGFRGTVERTCIKARATKKWEPGSCSAKNVKGSARIKPPRLTRNVQLWPTVSYNVCPSPRLLHSTYVPSRIQPCADLILAPYEPDLERTAYRRRTAKQPNKPSAAGELTHPEIPAPTPAHDFQFSGSCLMSQGFLASDPAARLCGETLLCRQQMLPFASSGSKVTPRQHMASYSNGYPRATTFELSPHSELETVRYYDLNDVQGTARGWEREERILVCVPLRDAEQHLPMFFSHLRNFTYPHRLIDLAFLVSDSKDRTLEVLTHYMSEIQESGDPNMMFGEVSIIEKDFGQVVNQDVESRHGFAAQAPRRKLMARARNWLLSAALRPYHSWVYWRDVDVETAPYTILEDLMRHNKDVIVPNVWRPLPDWLGGEQPYDLNSWQESDTALALADTLDEDAVIVEGYAEYATWRPHLAYLRDPYGDPDMEMEIDGVGGVSILAKARVFRYGVHFPAFSFEKHAETEGFGKQMAKKMKFSVVGLPHYTIWHLYEPSVEDLKHMEQMERERLAREKEEKEKAEKAQKLKESFGDATSQWEEDKSKLQQVAIAESQKKQEDAQKAAAAGSKTGEKAEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6H9</accession>
    <name>G0S6H9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0026280</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693086.1">
        <property type="nucleotide sequence ID" value="XM_006693023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6H9"/>
    <dbReference type="STRING" id="759272.G0S6H9"/>
    <dbReference type="GeneID" id="18256666"/>
    <dbReference type="KEGG" id="cthr:CTHT_0026280"/>
    <dbReference type="eggNOG" id="KOG3072">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017661_2_0_1"/>
    <dbReference type="OMA" id="WNQGLAY"/>
    <dbReference type="OrthoDB" id="10259681at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF169">
        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS20790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="460" mass="50232" checksum="4C2EC86B5F952B96" modified="2011-10-19" version="1">MASLPVFLSFPPSSLLRVPPEGADTSGFVPPPPAGSTPSAPPFDIPDHIYYAALDFRVPITIATIYAVTAKLLNAYNKANGKKPWAISKTFFFHVFVILHNVFLAVYSAWTWWGMFNTLRRTVVSPLGPTGVAGLVDSICGINGPAGLGNAAFFDPKTKTWQSYAADASAVFGPDGRPSRFATGRLWNEGLAFYGWLFYLSKFYEVFDTLIILAKGKLSSTLQTYHHAGAMLCMWAGIRFMSVPIWIFVFFNSLIHAIMYTYYTATALHIRVPMFIKRSLTSMQITQFLVGGSLAMAHSFVHYTIPVIAGSKTDSASGAAASAAAGSESGRLIAVNLRDDGFQGEYTSQDMPCITNNGATVAVWLNVFYLAPLTYLFVAFFIESYLRRSNAAASAQAAARRTGGVDARRLSNVQLAEKAGWEAAKNIEREVYGENTEEAVVSEKSSKKANGKGRVLRNRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6P4</accession>
    <name>G0S6P4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase II degradation factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CTHT_0035110</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DEF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693942.1">
        <property type="nucleotide sequence ID" value="XM_006693879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6P4"/>
    <dbReference type="GeneID" id="18257549"/>
    <dbReference type="KEGG" id="cthr:CTHT_0035110"/>
    <dbReference type="eggNOG" id="ENOG502S359">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008092_0_0_1"/>
    <dbReference type="OMA" id="MYQNQFP"/>
    <dbReference type="OrthoDB" id="5396806at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14368">
        <property type="entry name" value="CUE_DEF1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041803">
        <property type="entry name" value="DEF1_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051833">
        <property type="entry name" value="TC-DDR_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16308:SF13">
        <property type="entry name" value="PROTEIN LINGERER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16308">
        <property type="entry name" value="UBIQUITIN ASSOCIATED PROTEIN 2-LIKE/LINGERER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="CUE" evidence="17">
        <location>
            <begin position="74"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="101"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="349"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="450"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="650"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="784"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="354"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="373"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="458"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="490"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="501"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="537"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="588"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="656"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="687"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="815"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="850"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="888"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="898"/>
            <end position="908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGS21646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="955" mass="98745" checksum="7947AA125031E381" modified="2011-10-19" version="1">MSEVQSRPAAPRGRGSGRGGRGGFASRGSGRSGARPATNGDSKHDTESSSLPTLEDEGEIGRLKKLYGSKVAGIKELFPDWSEVDILFALQETDGDENLASTRILEGSISQWGEVSKPKKDRSRPKNKSDATTANDAASANASRHGRGGRPVDSGRGRGRGGARGKPSHATTNGARNKESQPLSVPTEESSEWNAKPAEEPAASRESTAAENATPSTTTPATPTPASKPAVEPVKTWASMLRQATAPKPAPKPKEPPVKPPAPEPVVEPLPPAEPAAPAEEEKASAAEEEPAAPEPAPEPVEEETKEPAKEPAKEPAPAPAVEPIVPAVPIIPAVPAILTPAVPEVALPPSKDQLTEKNLDKIADDSHPPPTETAASEAADSWDPNAQAPSATATPISASQQQHQAARSTAPAKPAGRTGSHARRMLDQLEAVRMPAIRDAVDRAAVQFGAFSLNGPVDDDIDGDREEPETRPQPPQDSPVSQPRASLPPAQTTSVSESFPAQKPTAPATSTPAAAPAAPVPSTAPQAPAQPPAVQNNQQFGRFGQPTSQESTFPAAKPFEPFGQQQQQQQPVSSGPQTHFEGGFQGQGQAAQPQAQQQPVGPFSSAPADFSSYYTADHQNRYNYYNQAFSQQGMQGQDALSSQAQRSFGGYTAPQADNLSQYPQSGTQQPSRFGAGAGTDAQIGGAANPVAASSQAQAAPTAQAQSHAQQQPHDYPYSHPYYTNPYYSAYMNYQGGYNQYGPYGKGGLGYQPSQYGISPQGPHAYSSPAGAFGQSGLHRDAGLGDYGRAGSQTGQQGLGTGFGVHDTYGRSGAGYQSQGTQSFNAPGSQPAATTSVTDDLKPFGESKTASGPSPSMGAAARPGSAANNGPSQTGLPPPQSAQQTALGGMGGYGGYPGHLQQGHGLHGAQTGAGAFGMGASSAQGHQNSYGAYGGQGFAGSYYGNPPRGWGNNYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0S741</accession>
    <name>G0S741_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative carbohydrate transmembrane transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0027350</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693192.1">
        <property type="nucleotide sequence ID" value="XM_006693129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S741"/>
    <dbReference type="STRING" id="759272.G0S741"/>
    <dbReference type="GeneID" id="18256773"/>
    <dbReference type="KEGG" id="cthr:CTHT_0027350"/>
    <dbReference type="eggNOG" id="KOG3912">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025028_3_1_1"/>
    <dbReference type="OMA" id="FIYKHNV"/>
    <dbReference type="OrthoDB" id="29773at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012404">
        <property type="entry name" value="UCP036436"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036436">
        <property type="entry name" value="UCP036436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="93"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS20896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="445" mass="49184" checksum="94B7C1BD1DBCA164" modified="2011-10-19" version="1">MASASFRSRALIPFLVSMMLFTGVCNTLLTKYQDNQCVRNCDDPDPAKRQHFEQPVIQTLQMFLGEMGCWLVVAVMEFHRRYFGAGEKGKARHTYQPVRTTADDEEDGTAPRHAADNASIRSTTALNPSGHNDNGTNNNNGCWCGSQKPHDCPSVLAGWRVMLLALPAICDIMGTTLMNAGLLLVAASIYQMTRGALVLFVGIFSVVFLGRRLYAFQWISLVGVMLGVGVVGLAGAIQPDSKHPVSAAALDSVGADALRVIVGVLMIAGAQIFTATQFVLEEWILERSAIQPIRVVGWEGLFGFVITLLGMVVLHLAIGRTEAGRYGPFDMVEGWRQFWEYRPVFVSSILIMISIGGFNFFGLSVTRSVSATSRSTIDTCRTLFIWMVSLGLGWETFKWLQVVGFALLVYFTFLFNGVVQPPFQCLRPRDRIVEELLPEEPIEHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0S774</accession>
    <name>G0S774_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">NAD(P) transhydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">7.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Nicotinamide nucleotide transhydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">CTHT_0027680</name>
    </gene>
    <organism evidence="28">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>NAD(+) + NADPH + H(+)(in) = NADH + NADP(+) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:47992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="7.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">In the C-terminal section; belongs to the PNT beta subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the AlaDH/PNT family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.1" evidence="5"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693225.1">
        <property type="nucleotide sequence ID" value="XM_006693162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S774"/>
    <dbReference type="STRING" id="759272.G0S774"/>
    <dbReference type="GeneID" id="18256806"/>
    <dbReference type="KEGG" id="cthr:CTHT_0027680"/>
    <dbReference type="eggNOG" id="ENOG502QQ0A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003376_0_0_1"/>
    <dbReference type="OMA" id="EQCREVD"/>
    <dbReference type="OrthoDB" id="37244at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008750">
        <property type="term" value="F:proton-translocating NAD(P)+ transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05304">
        <property type="entry name" value="Rubrum_tdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000028">
        <property type="entry name" value="NAD(P) transhydrogenase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000002">
        <property type="entry name" value="NAD(P) transhydrogenase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008143">
        <property type="entry name" value="Ala_DH/PNT_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008142">
        <property type="entry name" value="AlaDH/PNT_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026255">
        <property type="entry name" value="NADP_transhyd_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024605">
        <property type="entry name" value="NADP_transhyd_a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034300">
        <property type="entry name" value="PNTB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00561">
        <property type="entry name" value="pntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006942">
        <property type="entry name" value="PRK09424.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10160">
        <property type="entry name" value="NAD(P) TRANSHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10160:SF19">
        <property type="entry name" value="PROTON-TRANSLOCATING NAD(P)(+) TRANSHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02233">
        <property type="entry name" value="PNTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12769">
        <property type="entry name" value="PNTB_4TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00836">
        <property type="entry name" value="ALADH_PNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00837">
        <property type="entry name" value="ALADH_PNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="13" id="KW-1278">Translocase</keyword>
    <keyword evidence="8 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 24" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="569"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="596"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="636"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="662"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="686"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="712"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="743"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="775"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="870"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="894"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="26">
        <location>
            <begin position="116"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="25">
        <location>
            <begin position="261"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00054910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00061558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00074145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00079255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="EGS20929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1119" mass="117275" checksum="723D692D33047F24" modified="2011-10-19" version="1">MMLLLLIRPASAIQVCWVSRQSQIGLLQRTARLLDNHTTRIGLRATGRAWHSTIHKGQLSTPSLALVAKHRPLQLIRHASVMSSIPLKPSTAGFVSSASNPATVVPTTPYSQLSIGIPKETYPNERRVAVTPQNVALLLKKGFKSVLVEKGAGAQADFLDEAYAAAGATLVDDASAVWSQADIVLKVRGPSAAEAEKAREGQTIISFLQPIQNRPLVEKLAARKATVFAMDMIPRISRAQVFDALSSMANIAGYKAVLEASNNFGRFLTGQVTAAGKIPPCKVLVIGAGVAGLSAIATARRLGAIVRGFDTRSAAREQVQSLGAEFIEVDIQEEGAGAGGYAKEMSKEFIEAEMKLFTDQAKDVDIIITTALIPGKPAPKLITKEMVEVMKPGSVIVDLAAESGGNCELTAPGKMITHKDVKIIGYTDFPSRLPTQSSTLYSNNITKFLLSMAPKDKEYGIDLTDEVIRDAIVVQNGEILPPAPRPTPPPAPTPATAAKETEVVALTPFQKVSREVALVTGGMSSILALGKFTGPMFMSNAFTFALASLIGYRVVWGVVPALHSPLMSVTNAISGMVAVGGLFILGGGYLPETIPQAFGAASVLLAFVNVSGGFIITKRMLDMFRRPGDPPEYPWLYAIPGLLFGGGFIAAASTGAAGLVQAGYLVSSVLCILSISGLASQATARMGNMLGMLGVGSGVLASLLAAGFSPEVLAQFAGLATIGSILGFIIGKRITPTDLPQTVAALHSVVGLAAVLTSIGSVMADLSHVSLLHLITAYSGVLIGGITFTGSIVAFLKLAGKMSSRPTILPGRHAINSGLLATNLATMVPFLTMAPGSPMIAAGALAANTALSFIKGYTTTAAIGGADMPVVITVLNAYSGFALVAEGFMLDNPLLTTVGALIGVSGSILSYIMCVAMNRSLINVLFGGLSTPTTQSNYKIDGSVTQTTAEDTADALVNAESVIIVVGYGMAVAKAQYAISEITRMLRSKGIKVRFAIHPVAGRMPGQCNVLLAEASVPYDIVLEMDEINDDFGETDVTLVIGANDTVNPIALEPGSPIAGMPVLHAWKSRQVIVMKRSMASGYADVPNPMFYMPNTRMLFGDAKVTTEAIKAAIEVRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7P0</accession>
    <name>G0S7P0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0037010</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694127.1">
        <property type="nucleotide sequence ID" value="XM_006694064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7P0"/>
    <dbReference type="GeneID" id="18257739"/>
    <dbReference type="KEGG" id="cthr:CTHT_0037010"/>
    <dbReference type="eggNOG" id="ENOG502RS9S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048625_0_0_1"/>
    <dbReference type="OMA" id="FEPTHAC"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057231">
        <property type="entry name" value="DUF7909"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051836">
        <property type="entry name" value="Kremen_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269">
        <property type="entry name" value="KREMEN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269:SF16">
        <property type="entry name" value="PROTEIN SLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25486">
        <property type="entry name" value="DUF7909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408926" description="WSC domain-containing protein" evidence="7">
        <location>
            <begin position="20"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="8">
        <location>
            <begin position="236"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS21831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="350" mass="38238" checksum="F30CD19938570921" modified="2011-10-19" version="1">MLNRKSVSALVAGAALASAQCTLPTEPLTNNLTFPFRVQVQNATRSEVHNKFMNLYEAGGGDQHLFIGPVGVPTYDFTLINGVINHEPKGVRAVIGGEFSEIDHTTKMFMTERGDPRAIFQPTWACNPDTDEPQIELQFVEMQGETPGGWICVRSSFDGSHEFRYYPPGNELVDPNRECIKVTLVAIEVDPSEIPAYPTTTATTLVTSTVAATSTAPAATSTHDPSALFADLTHLGWRFIGCAPEERWANDGPFRTLSGAMFGSDYMTNEACMAFCEGLNFAFGGTEWSRECWCGNSYAPTREPNTTLASVANCNFRCSGDNAQYCGGDSWLSLYAKCDEEEECENATFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7Y1</accession>
    <name>G0S7Y1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0037400</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694164.1">
        <property type="nucleotide sequence ID" value="XM_006694101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7Y1"/>
    <dbReference type="GeneID" id="18257778"/>
    <dbReference type="KEGG" id="cthr:CTHT_0037400"/>
    <dbReference type="eggNOG" id="ENOG502QTP8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005757_0_0_1"/>
    <dbReference type="OMA" id="KQSHDSW"/>
    <dbReference type="OrthoDB" id="435520at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF10">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="566"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="690"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="925"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="925"/>
            <end position="936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS21868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="944" mass="102794" checksum="3D9E41E582688D2C" modified="2011-10-19" version="1">MEHTSLSAASSSVHLKSRDREHDPLSDWTSRDRSRHSKSTREEPDDYQAAPVPPASPEVISSLITSLSAISRPVSNHFDGPSYLSPIGIGSPLSSVPGSPTAGSFGVDYGTYNQPSLKELREEDEIPLDELPASPPVVRTSKLPSSLSTLTAPKSPRSPGARESTGFLSIRSRRSSGGVSRPSSRGSFTSGAESIGKPSVERAPDALSPPRHSLRKQKSYDSWGFKGHRSLIYMGSKEKLRDKATEKKRASIGAVGGDINIPGSKTEPPTPRLQPSFTDSAISEEPATIALETSALQPAPVFHDSLPSPGLIPTRDSSLRKTGNNAKRSSVRTSRHSRKDSESDAYDAIPELDEQNAKPRDSRSEKSKRRHSGRKQNLGLDPLKLSADLAKDAALPGPSTPAAAMFPDGIDDGAPSPAVAQGRRRDRETSIDFRRRSGRLTPDPFGGYASEGGNPTVKLKRSSTRLKRRSGAATPTSEKSGAGGSNYDHPHVAYERPRSADSIDDAVESYLCSPRLSQKIRHPQTGRVISFSEVGDPNGSAVFCCVGMGLTRYITAFYDELALTLKLRLITPDRPGVGDSEPYPDGNATPLGWPDDVYAICQSLKITKFSILAHSAGAIYALATALRMPQHIRGRIHLLAPWIPPSQLNVIGATSQTPLPPTNAIPTSQKILRALPTPILKAANSSFVTATSSSLTSSLPKQKRTKREKRHTDTKENKDQPKGILHSPMDKENINQTNDLSKSLPELPAPDEDMDRIRPTPANGNSHDPSLPRARGIGHRHRRSNSQGLRRRSEQDAHLLSSAASLATSQADKERQELYDSRLTHAIWQLATTGANPAVDLLVCLERRHTIGFRYVDITRPVVIHHGSKDTRVPVENVRWLGKMMRRCEVRVLEGEGHGLMASAQVMSNVLMEISREWEEWSRVTGANKRENEKGRRGTIGQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8A8</accession>
    <name>G0S8A8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ring-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0038160</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694238.1">
        <property type="nucleotide sequence ID" value="XM_006694175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8A8"/>
    <dbReference type="STRING" id="759272.G0S8A8"/>
    <dbReference type="GeneID" id="18257854"/>
    <dbReference type="KEGG" id="cthr:CTHT_0038160"/>
    <dbReference type="eggNOG" id="ENOG502S3A7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031806_1_0_1"/>
    <dbReference type="OMA" id="PAFIGMN"/>
    <dbReference type="OrthoDB" id="5398191at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="310"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS21942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="40179" checksum="3776BCE6298B2565" modified="2011-10-19" version="1">MPSFFKKSRPKEAAADAAKLSASAATQTPGYPATPTPDEDIPAAPSRRDEAEKQQEQSEEPAPALLDDEDERFLEHLVGDVEGKDGDKADGSKRPMPSRPRTPDLIEAWGGEEVTGSSADAASPKKQKQSRLSRLFHRTSKPKQTATDTTTEDEADREWADLNRVLARLDLSPETKAKAKAKKDKASAELKELVRQFVLVLKDIMRGAPTAVDDLIKLFDGRNDAFRRGFEKLPPGMQNIVTKLPKKMAESFGSEVLSAAKDAAVKEIGKEGTKGVKELLLPKSLGDLTLTPAVVQAMLRAIVNALKLRWPAVVGTSALWSTAVVLLLFVLWYCWKRGKEEREKEERERAEDQARAPAEVEAAKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8D0</accession>
    <name>G0S8D0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0021310</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692601.1">
        <property type="nucleotide sequence ID" value="XM_006692538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8D0"/>
    <dbReference type="STRING" id="759272.G0S8D0"/>
    <dbReference type="GeneID" id="18256169"/>
    <dbReference type="KEGG" id="cthr:CTHT_0021310"/>
    <dbReference type="eggNOG" id="ENOG502SIKX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2637856_0_0_1"/>
    <dbReference type="OrthoDB" id="4586862at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS20305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="77" mass="8672" checksum="0E7F98F663F3E159" modified="2011-10-19" version="1">MLAPAQYIAGVGTSDISNLGFLAYNIHMQYMWYRDIINPSAPENVGPLCLLIPHFNVIYAISYVGGVSSRNHIWLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8G5</accession>
    <name>G0S8G5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 5A</fullName>
            <shortName evidence="8">eIF-5A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0029800</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="8">eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eIF-5A family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693435.1">
        <property type="nucleotide sequence ID" value="XM_006693372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8G5"/>
    <dbReference type="STRING" id="759272.G0S8G5"/>
    <dbReference type="GeneID" id="18257018"/>
    <dbReference type="KEGG" id="cthr:CTHT_0029800"/>
    <dbReference type="eggNOG" id="KOG3271">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102600_1_0_1"/>
    <dbReference type="OMA" id="KDDVRMP"/>
    <dbReference type="OrthoDB" id="9975114at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006452">
        <property type="term" value="P:translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04468">
        <property type="entry name" value="S1_eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000007">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000034">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048670">
        <property type="entry name" value="IF5A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019769">
        <property type="entry name" value="Trans_elong_IF5A_hypusine_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00037">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01287">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21485">
        <property type="entry name" value="IF5A-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003025">
        <property type="entry name" value="eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01376">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00302">
        <property type="entry name" value="IF5A_HYPUSINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7 8" id="KW-0385">Hypusine</keyword>
    <keyword evidence="10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Translation initiation factor 5A C-terminal" evidence="9">
        <location>
            <begin position="87"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS21139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="160" mass="17584" checksum="E677BA3E1C58C7D3" modified="2011-10-19" version="1">MSDEHHDFEHEGHADAGASLTFPMQCSALRKNGFVVIKGRPCKIVDMSTSKTGKHGHAKVHLVALDIFTGKKLEDLCPSTHNMDVPVVKRNEYQLIDITDDNYLSLMLSDGSTKDDVRLPEGELGQKIKAAFDEGKDLLVTVQAAMGEEAAIDFKENTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8P6</accession>
    <name>G0S8P6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Potassium transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0039880</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988042">
        <property type="protein sequence ID" value="EGS20249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694398.1">
        <property type="nucleotide sequence ID" value="XM_006694335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8P6"/>
    <dbReference type="STRING" id="759272.G0S8P6"/>
    <dbReference type="GeneID" id="18258026"/>
    <dbReference type="KEGG" id="cthr:CTHT_0039880"/>
    <dbReference type="eggNOG" id="KOG1341">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005947_4_1_1"/>
    <dbReference type="OMA" id="YAVWRET"/>
    <dbReference type="OrthoDB" id="9999863at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF37">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="536"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="179"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="588"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="700"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="293"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="593"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="640"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="708"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS20249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="868" mass="95714" checksum="FE1CBD91D9473CFB" modified="2011-10-19" version="1">MKLSPKTSDRFRTRFSSIASRLADHLSPLRPYLPPINFITLHYAYFIFLSLFLSLIFYAAHSPTPSKSSNEDIARRRISYLDALFHTVSSLTGTGLNTVPLCDMSVGQQVVLFLAMLAGHPVLVSLGAVWFRKDVFEKKFREIVQRERERKEKMEGGRLGKALVRRVTFNLALTLTRERSRDGDGDRGGLAGLGTRIKERREGERMSPTPTPNSSSNQTRERDRDRERDLEPGLPPIHEQQDPNPNTSSLLSPQPQFLFPSPPSHSPASRSIQFIEPPRPDRPSPSLSPSPDPNNNNNNNESGNDTPDFIARLRHSHTRNASFANLTLSERQYLGGVEYRALEVLIVTVTAYFILWPLFGAIALGAWLSRHGGQVSEQETGEKSPSPNPWWEGIFLSVSAFGNGGMVLGPEMGSFLDRGVGGVFVLLVVSLLTLAGSQASPVFLRVIFLGLWGILKRVVADEGGYAVWRETFEFILRYPRRVYINMFAARDTWRLAGWLAAFLAVDWVLFWLLNIGNGEVEGMPRGKRVLGGLAQSISNLSGGFAIIPVSAVSFSLQVFWLIKIYASAYPTSITVRGSNVYEERSLGIYMGDEPPDSDDSGSDNEKRPAKAKPLPESEPEPEGTTTGLMIPSLPRPPLTPVSTTSQVSRLSTASRRGLTKLVGITRQGTAFMGRQIQRRMTTGFQGVGVSASAALPIPQKSTLPTFNTPATSTSSKTTTAPTPAPKPDLTTHHARSQLSHDIPLLALSFLLLVLIETPHISSSPLIYSLWNILFELVSAYANNGITVGFPGRDYSFCGGWRKLSKLLLVGVMLRGRHRDLPVALDRAVKLPREGDWDGEEEEDGEIRKIISRSPAVGRSPMLGRLNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8Q2</accession>
    <name>G0S8Q2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CTHT_0039940</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="GL988042">
        <property type="protein sequence ID" value="EGS20255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694404.1">
        <property type="nucleotide sequence ID" value="XM_006694341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8Q2"/>
    <dbReference type="GeneID" id="18258032"/>
    <dbReference type="KEGG" id="cthr:CTHT_0039940"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010365_6_0_1"/>
    <dbReference type="OMA" id="FWTEWVR"/>
    <dbReference type="OrthoDB" id="3944240at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="16">
        <location>
            <begin position="299"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="492"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="520"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGS20255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="620" mass="69582" checksum="21CFA8C87CFF900D" modified="2011-10-19" version="1">MDHNHGNSRFQPGNKDLARRYWYIIAGFVGGFAVCRIINLYKALVRLRRKATASVQFPTRPSNLFLSTWATATAITREASYPQLYIPLRPLSWLTPPPLGRFITLLVYWIIIITFMTDGAIVNDIYRRERLGFRNAWITITQLPLVYLLAGKCNVIGYLVGSSYERLNWLHRWVARTMLVAATVHGWMFFADWARYDFVKEQIKMMPMVKYGFGAWAVLVWSCLVGMAPVRRLGYEVFVFQHIVSAALFLWLLYVHVPAAARYNIWFAIAAWGFDRVCRFTLLIWQNVKLNPDRSNCAGGQRIGHQAQLRAIGESITVVTIKDVHFRWRAGQHLYLWIPRIGPLEAHPYTIACAHKVPETCICNSIQLVVRKHGGFSKRLHEYAVKLREKGKGKGTLTAFVSGPYGNPPRWDIYETVVLISASTGASFTLPILESVLKSGETNCVKRVDFLLVARQGEEIGFYVGRLRELVTLARCTGVELNVQVAVTREGLEKLEEPESGKGQGDGEPSASSSGSDLGQHGDKRASGDEERVGQREMRRRMSEGETEEVIAYFSSRPDIAALIRAAVEATGGETSVVACGGPSLTSRVRNCIASLSDERAVHKGTGAQGIHCFVEEYNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8X5</accession>
    <name>G0S8X5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Splicing factor srp2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0043780</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694771.1">
        <property type="nucleotide sequence ID" value="XM_006694708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8X5"/>
    <dbReference type="STRING" id="759272.G0S8X5"/>
    <dbReference type="GeneID" id="18258416"/>
    <dbReference type="KEGG" id="cthr:CTHT_0043780"/>
    <dbReference type="eggNOG" id="KOG0106">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_34_5_1"/>
    <dbReference type="OMA" id="PREPAYP"/>
    <dbReference type="OrthoDB" id="1099063at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF51">
        <property type="entry name" value="SERINE-ARGININE PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="8"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="153"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="205"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="238"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="252"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="293"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS19886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="307" mass="35811" checksum="8984A12161430BA6" modified="2011-10-19" version="1">MTTEVSSTRLYLGNLPKHATKADVEAHFSKHGTGEITEIKIMNGFGFIEYKDPMDARDVVPAFHGSMFMGERLTVQFARGNRHRDTANGYGHERAPPRPRRTPHRMEITGLPDGCSWQAGVDVVYTETSRRGNSWEGIVEFETPADMRTAIEKLDGREFKNSRTAQPSEPPRYDRGRSRSPIRRYPPPPLDDYDRRGPPPRGYSPRRDGYRDAYRERTPPPRREYYDDRRGGYRSPPRRGPPPIDDYPPPRGRYDDPYARPPRDYPPDPYMNGRPPYDHRRPPPPDFPPPRDPYPRDPYPRDYDRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G0S923</accession>
    <name>G0S923_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0044270</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694819.1">
        <property type="nucleotide sequence ID" value="XM_006694756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S923"/>
    <dbReference type="STRING" id="759272.G0S923"/>
    <dbReference type="GeneID" id="18258465"/>
    <dbReference type="KEGG" id="cthr:CTHT_0044270"/>
    <dbReference type="eggNOG" id="ENOG502SAS5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025004_1_0_1"/>
    <dbReference type="OMA" id="NGYHSKG"/>
    <dbReference type="OrthoDB" id="5054775at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031930">
        <property type="term" value="P:mitochondria-nucleus signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021711">
        <property type="entry name" value="DUF3295"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053043">
        <property type="entry name" value="Ras-cAMP_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28014">
        <property type="entry name" value="NEGATIVE REGULATOR OF RAS-CAMP PATHWAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28014:SF1">
        <property type="entry name" value="NEGATIVE REGULATOR OF RAS-CAMP PATHWAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11702">
        <property type="entry name" value="DUF3295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrogen regulatory protein areA GATA-like" evidence="2">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3295" evidence="3">
        <location>
            <begin position="87"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS19934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="588" mass="64776" checksum="C00D7C32E04ED329" modified="2011-10-19" version="1">MPLSLEAPVLQVDANVIHKVDTTNPANLFSMWTVFARCRDSVAQGRRLENLSWRLWNRETFCCENDDISLSTSTTSKPQDIPHGNTEDVPQLSGSVDSVADEEAVDFGTESAPVDIVRPRIRRQDSCASSRSRGNQRHITSDELEKMVVSIMESKEPLTAPLPNIPRCLSVEQRPASPRTGSTTSQSSCNSSDNLSAQSSASEPVREAAPQLPNQPRATIVTRGFSPAQVPATLLAAVQASKAPSPSAIPGPDEAPAAKPVFPKRQQAKFALGGSSCSEDGSYQQREIEARRQPTAQPRQKMFQLGASSVEDDSPREQRVAAAMTAQRKNTSFNKQVVTQTFNTSAVSDSEDDYSESAIDDSAIDDDDEWEEEDGEESDSGNAPEKIEFRRVESTANLTSRRSLITLMLAQTQYQVRNQSNARPQRFGNGIASQSTSALHRAGRPQLNGPTVVNSPNDSDEAPLMMKRNNNRAPPMRPINEIPRSAAQPINVAAQGMHFQAALSPRTTRRNMLATELTESLRRNLLRERSQKSSTANAVLKRRHTSHDIANLRQFPEKPFMKKEEDANASSWDQYFQNPFAGYSAQAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0S999</accession>
    <name>G0S999_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0045070</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694895.1">
        <property type="nucleotide sequence ID" value="XM_006694832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S999"/>
    <dbReference type="STRING" id="759272.G0S999"/>
    <dbReference type="GeneID" id="18258545"/>
    <dbReference type="KEGG" id="cthr:CTHT_0045070"/>
    <dbReference type="eggNOG" id="KOG2456">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_3_1_1"/>
    <dbReference type="OMA" id="EIDWCKQ"/>
    <dbReference type="OrthoDB" id="440325at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07135">
        <property type="entry name" value="ALDH_F14-YMR110C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000025">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000004">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF11">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="7"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS20010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="508" mass="56661" checksum="C55059FA013E6B10" modified="2011-10-19" version="1">MAITEFKATPLDTIPSIASTARSTFRTHKTKTLAWRKTQLRRLYWAIEDFKPRLLAALRADLHRSDYESLLTEIEWLKKDCLFMLEHIDEYAKDEKLKSPDVPVAFAAMKFRIRKEPLGTVLIIGPYNFPVQLLISPLIGAIAAGCTAVLKPSELTPSVAMVIKELVEARLEKGAFAVVNGGVAETSALMEIKWDKIFFTGSSAVGTIIAKKAAETLTPVTLELGGRNPAFVTKNADLQLAARRLLWGKTVNCGQVCLSQNYVLIEKGLVDKFVEALKQAYKEMFPEGAKKSPDLARIVNKRHFARIKKMLDETKGRIVIGGEVDESELYIEPTAVVVSSVDDAMMQEESFGPIFAIYPVNTLDEALNVANLVHRTPLALYAFGSKKENERILNEMTSGGATLNDAFFHGSVNTIPFGGVGDSGLGCYHGRWSFDCFSHKRTVAETPRWVEPLLRVRYMPFDVKHMKRLAMLTEKKPDFDRDGKLIKGWAYWIKLLITLGGGSVKDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9I2</accession>
    <name>G0S9I2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0045980</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694978.1">
        <property type="nucleotide sequence ID" value="XM_006694915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9I2"/>
    <dbReference type="STRING" id="759272.G0S9I2"/>
    <dbReference type="GeneID" id="18258636"/>
    <dbReference type="KEGG" id="cthr:CTHT_0045980"/>
    <dbReference type="eggNOG" id="KOG2402">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019525_0_0_1"/>
    <dbReference type="OMA" id="ISGCYAR"/>
    <dbReference type="OrthoDB" id="166375at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.200:FF:000005">
        <property type="entry name" value="Related to Pol II transcription elongation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.200">
        <property type="entry name" value="Plus-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004343">
        <property type="entry name" value="Plus-3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036128">
        <property type="entry name" value="Plus3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115:SF8">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03126">
        <property type="entry name" value="Plus-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00719">
        <property type="entry name" value="Plus3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159042">
        <property type="entry name" value="Plus3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51360">
        <property type="entry name" value="PLUS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Plus3" evidence="6">
        <location>
            <begin position="300"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="142"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="509"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="194"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="291"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="511"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="536"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS20093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="689" mass="78775" checksum="595B7ADAF89FF8F4" modified="2011-10-19" version="1">MSDIDDELLALAGGDVSEGEDAGEAMDISRDNSSPRHRDDAASDKDDDDDKDAPRRGTSARRAKRRSEDDEEEEEGEASPPGSPGSQMSAPMDESDSDSDTPQARTRGAAADDDNPYPVEGLFKSLEEKARIMSMREIEREQILAERREENERIRQNRMLRQLKVNQEKEKEKEKGKDMSKKRKAVDLDDDDDLHTGRRTDLRKSSRARTRADQSSDKMDSLRRAREERTSRKEARERENDRRRRDRDRDRDRSESSYGRSRSRSRDRYNRRPSSRDSDDYRRSKSRNRSRSPEPRESPPADMRDIERVRVGRSRFADYCFHPLFEQAMIGCFVRINIGPDPATRQEVYRMAVIKGFSKGRPYAIPDHSGHPMVVDTYVKAAHGKAQRDWPFISCSNNKFTEAEFNRYKQVCLAEGVPFPTKDELISKIDDINRMVNYVWTDEELNEKLRRVREMHAKYGPFQREAVQKQLELARARGDEEAVARLQERLDSLEVPRLAFRTGSLFPQMKTSTTATTTTTTTTTTTTSSSSSSSHGGNGENGNGVGLSQQERLARKNLENRKYNSEMVRKAQLAERAKAREIELRTLRGEPVEDGDLSRRVRTRVKFHYDPSQDSLVTPKKVVQSNGTSGTNTPANGENKEEVLPVIAKLKEQQWEQAKKQGGMPSIHRPLMDDDIIGAIDLELDVDIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9N7</accession>
    <name>G0S9N7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0046550</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695033.1">
        <property type="nucleotide sequence ID" value="XM_006694970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9N7"/>
    <dbReference type="STRING" id="759272.G0S9N7"/>
    <dbReference type="GeneID" id="18258693"/>
    <dbReference type="KEGG" id="cthr:CTHT_0046550"/>
    <dbReference type="eggNOG" id="KOG0894">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041481_3_0_1"/>
    <dbReference type="OMA" id="DEENWKW"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000058">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="3">
        <location>
            <begin position="6"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS20148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="273" mass="30030" checksum="727C4E5F6D41E671" modified="2011-10-19" version="1">MAASPAARKRLTREYKAIMENPPPYIQAHPSENNILEWHYIITGPENTPYHGGQYWGTLTFPPNYPFAPPAIRMHTPSGRFQPSSRLCLSISDFHPRSFNPAWEVSTILIGLLSFMTSEEMTTGSVSASEAERKQLAFKSRWWNSTGGGSHIRGEHGAAGKNNIRAGDGGAKFRQEWPELDEENWKWMRENKIDPATGNKVVEPSTAPAPATPCGPQLGLPAGSGHQAHAVVDAVRQQRDAGQSWIFQNKLFLAGAAIFIYVLIARLVGEGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9Y8</accession>
    <name>G0S9Y8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Imidazole glycerol phosphate synthase hisHF</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="12">Glutaminase</fullName>
                <ecNumber evidence="12">3.5.1.2</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="12">Cyclase</fullName>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CTHT_0040360</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">In the C-terminal section; belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="12"/>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694445.1">
        <property type="nucleotide sequence ID" value="XM_006694382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9Y8"/>
    <dbReference type="STRING" id="759272.G0S9Y8"/>
    <dbReference type="GeneID" id="18258074"/>
    <dbReference type="KEGG" id="cthr:CTHT_0040360"/>
    <dbReference type="eggNOG" id="KOG0623">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037550_0_0_1"/>
    <dbReference type="OMA" id="GNYGHFV"/>
    <dbReference type="OrthoDB" id="10254903at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01748">
        <property type="entry name" value="GATase1_IGP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04731">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000094">
        <property type="entry name" value="Imidazole glycerol phosphate synthase hisHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000039">
        <property type="entry name" value="Imidazole glycerol phosphate synthase hisHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00278">
        <property type="entry name" value="HisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004651">
        <property type="entry name" value="HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050064">
        <property type="entry name" value="IGPS_HisA/HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014640">
        <property type="entry name" value="IGPS_HisHF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010139">
        <property type="entry name" value="Imidazole-glycPsynth_HisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00735">
        <property type="entry name" value="hisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01855">
        <property type="entry name" value="IMP_synth_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235:SF2">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE HISHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISF/H IGP SYNTHASE SUBUNIT HISF/H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036936">
        <property type="entry name" value="IGPS_HisHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 12" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 12 15" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="16">
        <location>
            <begin position="6"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="362"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="400"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="472"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="498"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="521"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="13">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="13">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="13">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="14">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR036936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR036936-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR036936-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGS19560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="552" mass="59946" checksum="50A04C19285F8F4F" modified="2011-10-19" version="1">MPKVHLLDYVAGNVRSLVNAIEKVGYEVEWVRTPEEVANAEKLILPGVGHFGHCLSQLSSAGYLPAIRAHIDAGKPFMGICVGLQALFSNSAEDPSCPGLGIIPGALNRFDDSAKAVPHIGWNNATCPAKPDLYGLRPDSKYYYVHSYKYPYRKGELESLGWAVATGTYGCETFIGALAKGNIFATQFHPEKSGVAGLRVIRAFLDGSGAKDLAEKPPTNINEVSDELISQEGLTRRVIACLDVRTNDQGDLVVTKGDQYDVREKSADRSVRNLGKPVDMAKRYYEQGADEVTFLNITSFRDIPVKDLPMLEILRRTSETVFVPLTIGGGIRDTVDVDGTKVSALDIATMYFKSGADKVSIGSDAVIAAEEYYKRGKVLDGKTAIETISKAYGNQAVVVSVDPKRVYVSSPDATAHATIKTKFLGPNGEEYCWYACTIKGGRETRDFDVVQLTQAVEAMGAGEILLNCIDKDGTNSGFDLELINHVKSFIKIPVIASSGAGNPGHFLEVFQKTTTDAALGAGMFHRGEYTVQQVKEYLAQKGLTVRKHEGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G0SA76</accession>
    <name>G0SA76_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0041270</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694533.1">
        <property type="nucleotide sequence ID" value="XM_006694470.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0SA76"/>
    <dbReference type="GeneID" id="18258165"/>
    <dbReference type="KEGG" id="cthr:CTHT_0041270"/>
    <dbReference type="eggNOG" id="ENOG502QQEE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000817_0_0_1"/>
    <dbReference type="OMA" id="DARTWES"/>
    <dbReference type="OrthoDB" id="5370537at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="143"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="379"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="570"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="778"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="852"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1034"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1126"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1247"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1412"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1571"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1950"/>
            <end position="1994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2107"/>
            <end position="2152"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2000"/>
            <end position="2027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="450"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="469"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="498"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="572"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="653"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="665"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="683"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="714"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="899"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1034"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1071"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1084"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1149"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1260"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1421"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2107"/>
            <end position="2119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2132"/>
            <end position="2146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS19648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="2251" mass="245842" checksum="51327202755AA246" modified="2011-10-19" version="1">MAVEGATQALVAAFFFGIVLNAASAAFVLYIKGHDGSVFRDSQRLVLVLFLCSAALWALVDFVSILLNNTTSTTPCQIGVIFSTVFDQLARFSLEQFLLWAMNSNSNGAKLPVTQLLPQAAVALRFIAGAVFTGFTRPQVDTFCVATTAITPLGIAVAGLDGAIIVLLVVRAYSPGGLARENRTGKEAEAERARGVMSILLGLTVWTGTSVPLLVGLESIALAVRTALPAAGLYMVILLVTSRAGTLFPARSQSRPPEAPSPRRFNITRDIATSHSDYPPSRYEDLKEAAIRSSTTFINPREAPVAKEETSIPPRPAALAATRNAEPPTPQRKKALFGGGKTNTKLTISRPIMQEDASQNLMNRIPVMDLKDAAVAEKERRERRGDLGLGIVPSKTPTSAMSPEEGVQRATSIKRKQVGSPPSRQSMFPGALRPEDVGTAMTTSAQRSPGGEEARRRSPRLSSDDEQRSITTFTVDTNRLTIAQTAVFTKPDIRPSRTLPPSPPPAPQEPAKTPLQRRPTIGLPQNPRARGVQVPQESGSRTKTILFVNNIEYNDPMVVQSIIKDVSQKAPKAPPASAPVPAPAPATAPITSTAYNTKPAKANPIPPTPGTSDSIINRPRPIPRKKDVDSPAKFSPRQSHRRSKSAGALVARSILSSSTPGSPSQLPPLPPLPPSTVVPPRPHPNDTRSMTVEEKITLLFPSPPSGKVTRRRSSSVPEVPSIPKSPIDIPSPVDSERRTTKTSVRTESVLEVDEIPRKSATTLLKTAGEAAASSWLEAFDAKEKPAIPKSTAAQDGGKRKSSPVLPGTTLPPRVSAWTTTTVMTEDDATTNWSAVQSPEFAVGVPVIKNIGPPAGLRGSDGGAVAAEDDARRSETLPIMLDASTVPVEDIKGEEGEQPAPQSQARKSPEQAQYQPARWHRRVGDECPTFSTRKENRRSRKLSPPPPLTLKATTTARHKITIQVEPSPPSPVESPEKAIQELRERLRKLEEFDRNSPGSAARRLALLESLEKEVGEQVEHLEEIRHDVERDSISSISTTSISATASQRSSLRDSLALQSSSRRASRLSRVMRLREEDRMERSSNRDSGSPQMSRWQKRLTEVQMEYMDVQLLRTSTVSFLQVARAQLTSPTPPDSDSDQGEPEPVPPIPDKFKQSAEHLQKEEPKKAALLWTPPVKESERPLGLLWTPPARKSAPAEDVTLPGLTLRPALRKDFEPLRIESSQLWHKPCQIPSRPSSGLWRPIWASAAPPAEPVRSIKSSPQTTTQEQQPQQQEQKQDPPKQQQKPRPSTLRPPRRTKRITMLPDILESPEPLPDRRDTLGIFQFPWGERSDTATLPPRPVAGMSMGFTAMPGTMTTGGLGMAPATHMQMQMQMQMQMQMQAASTGFTAPPAPAVSAIEQYGESFFDDYDDDAFLDEMPSNSEDEDDDSAEFDDSTLWEIANLLRTDAGEESEEENSPRAQSILIGLDEAPQALSLPEPPSNRTSSATVTVMMVEESTPSDPKQPVRRPSIIGLPVNPKANLQAVQAQSLPTSESQAQFTSSAPEPAALTVSAGQGSAGLWVPPEEKFKKVSSQGHQGLFVPPSPGSKDKSKPVVVDAEPAAKNVVVIRKPRSVVADLTPLESSSLWTPCVSEKKVERNWIVFSTRTSSSSSPSLGLVGLWSPPKKVKETASVTGLFVPGSVLFRGTDQEPIAKDLARKVRPVEDRPLDRLTSTSLWSPTAVVKKVEHDWISELPRGLPGLWLTPSKVKEVKSANGLFVPGSVKHRGTAAEPIAKETPRKPRAVDTKPLEKITSANLWTPKQTSKDIVGKNWIFHSTTRRFRRPLATDADWTAALNEALKASYPQKKLRRTVANPAQWQAALQEALSLSYPQKQTEPFDAATRHPVFAARSLVTRSPWFHPAATGYTYDVAAVHPVFFGSLDISSVQLVNEDEELSVEAVHPAIASYAARKIRRQRRRERKELSRSRSRSGSGSSSEKESSKSKHKKERSTTETVVLPPVSADIQARIEALEQERQFIERAAREEYRRRTSMMSQTAVQAPLPVVEAVPSPSFSPAGTTSVIPAATEAVEALQRRLSLHIRQSLAFAKPTKVEVAKPAKVEIIKSRSKAREPVKLQEKKPTQPAQLWTPPKPTTAALPKTSTTTPTAGLWSPNADHSPSVAFPSEEEDAFAKQSRAHRRKLLQKRQRRVEILAQIAAIEQGVNPFVENSDEWRMQGLWTNGFGGAVREKERGWGREWILMGGKKARGVVLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAA0</accession>
    <name>G0SAA0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0041510</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694557.1">
        <property type="nucleotide sequence ID" value="XM_006694494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAA0"/>
    <dbReference type="STRING" id="759272.G0SAA0"/>
    <dbReference type="GeneID" id="18258189"/>
    <dbReference type="KEGG" id="cthr:CTHT_0041510"/>
    <dbReference type="eggNOG" id="ENOG502QQV2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058877_0_0_1"/>
    <dbReference type="OMA" id="HPMLDHF"/>
    <dbReference type="OrthoDB" id="7772923at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43844">
        <property type="entry name" value="METHIONINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43844:SF2">
        <property type="entry name" value="SYNTHASE, VITAMIN-B12 INDEPENDENT, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12060)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS19672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="379" mass="43285" checksum="0539B9037246A688" modified="2011-10-19" version="1">MSSPTYIPRRPPFRAEHIGSLLRPKPITNRRLQLDGLDALSIAQDMTLRQLEDVAIVNTVRLQRSLGYHAVTDGEYRRHQFWGTFFPGLEGFTEIRKPPMHIFRLYVPDLAAFSESVVCTGKIRHIGSTYLREWNYLKELLPPEMVPKAKITLPAPEWYHLRYKTGYAYPADVYANDEEYFTDIATVYHFCDTRLTKGLRNDHTAPDPDALLSAYISLYNRILTPRPGGPDLHIGVHLCRGNFAYSRHFSSGGYGQVAPVLFTQLDVDTYYLEYDTPRAGDFSPLAWLPRDKNVVIGLVTSKCGQLEDLEQLKKRVLEAADWVGKQSGQTREEAPKRMGFSPQCGFASHHLGNSLTWEDMVEKLKLVRRLTDDIWPGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAB0</accession>
    <name>G0SAB0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0041630</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694567.1">
        <property type="nucleotide sequence ID" value="XM_006694504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAB0"/>
    <dbReference type="GeneID" id="18258201"/>
    <dbReference type="KEGG" id="cthr:CTHT_0041630"/>
    <dbReference type="eggNOG" id="ENOG502SHEC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036005_1_0_1"/>
    <dbReference type="OMA" id="TAYYAQP"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000005">
        <property type="entry name" value="TfdA family taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF10">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="8">
        <location>
            <begin position="61"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="378"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS19682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="389" mass="43885" checksum="96F8462C2CC2B771" modified="2011-10-19" version="1">MAPSAVETAAPVVPEIKEKVLPGKAQTINPIANQPWEEVPELYTNHREPLKLSGALDHLEYFDVTPVIGREYVNVDLVELLRAPNSDDLLRDLAITISQRGVVFFRKQDNLTDDLQKELVDRLGKLTGKPATSGLHIHPVSNSQREHGTKDDEISVISSEQAKKLFSDRWNGTKRHQSSKQQWHSDITFEPIPSDYALLRLTQLPKTGGDTLWASGYELYDRISPTLRSFLDTLVAHYAQPGFNEAAKRNNFQLYTAPRGAPENVGEALEAIHPVIRTNPVTGWKSVFAVGHHVQRIYGLSEDESKHFLNWFVQLIVENHDLQVRYKWKNVNDVAIWDNRSVYHAATPDYIGEDLGERRGSRAVSLGEKPYFDPASTSRREALKAQKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAF4</accession>
    <name>G0SAF4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0042080</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694611.1">
        <property type="nucleotide sequence ID" value="XM_006694548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAF4"/>
    <dbReference type="STRING" id="759272.G0SAF4"/>
    <dbReference type="GeneID" id="18258246"/>
    <dbReference type="KEGG" id="cthr:CTHT_0042080"/>
    <dbReference type="eggNOG" id="ENOG502R6D6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_508056_0_0_1"/>
    <dbReference type="OMA" id="HNDNESP"/>
    <dbReference type="OrthoDB" id="4576515at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="131"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="179"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS19726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="536" mass="59604" checksum="CCE4B2470819DEB2" modified="2011-10-19" version="1">MPSPPITSLASPDSKDSVAAIRRDSVASPPPNIRPDSATSTKISSAKANMASDFQPLVAQSGLTEVSSTKSQVVNINTSNNLLQPLDEEPNTPSSTIVEFGDLAHGYVPPAAELVESIHWSYVQRHFESRLRSKHQEKQPSSSSSPPPHNDNESPRTDQNRSEPESELVQVIRNLYQRIAVLQHTEKELLAENQELSRKYIALKQHHDRRARQWNEALRRKETKYEARIADLGQQLLDLAATYPGKLPNILSNEEILSWFDEQDFLWFALARAFAHDDPDRLRKLYPAQLDELVSEVKEFVRLTEDEGLPPELLNGGKEVNNTASALGLPMSADMDRLPAAHIDTRLNYARKLKDRFLSSSARYLLRDQDASGIELLEHMLIEMLDSALRFSCRLWTRVVPHRVCGMRELSRRDWRLENPVSVLFHAQSSEVGCPASHLHEGCRDKMWEGYLASLVAGVAQQQQKSAGSSSEKSPAVVIIQPAIVAGVLEEGLLGPLITAEDAGGRPNARDDAKARVPVVWLRGRVIVSGFGAQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAN1</accession>
    <name>G0SAN1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="11">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0042870</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="11"/>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694688.1">
        <property type="nucleotide sequence ID" value="XM_006694625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAN1"/>
    <dbReference type="STRING" id="759272.G0SAN1"/>
    <dbReference type="GeneID" id="18258325"/>
    <dbReference type="KEGG" id="cthr:CTHT_0042870"/>
    <dbReference type="eggNOG" id="KOG0975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031922_0_1_1"/>
    <dbReference type="OMA" id="LTEVFAC"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000005">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009897">
        <property type="entry name" value="PRK13357.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS19803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="414" mass="46113" checksum="AA9A245D55C733E9" modified="2011-10-19" version="1">MMRHQLFRSAAHASALSAGRTGLAAPAWQQAVRQYSIAPAASETKLADIDPSQLVIERTTNPKPLKAAKDLIFGRNFTDHMLMIEWQNTTGWQAPRIVPYQNLSLDPATCVFHYAFECFEGMKAYKDKAGNIRLFRPDKNMERFNKSAARIALPNFNGSALIELIAKFTKLESRFIPEERGYSLYLRPTLIGTQKTLGVGPPGSALLFVIASPVGPYYPTGFKAVSLEATDYAVRAWPGGVGDKKLGANYAPCVVPQREAMGRGFQQNLWLFGEQEYVTEVGTMNFFVALRNKETGQKELITAPLDGTILEGVTRDSVLSLARERLVPQGWNVVERKYTMKELDEAANEGRLIEAFGSGTAAIVSPVRHISWKGKLINCGLKDHEESGEIAAKMKEWIEARQYGDDEHEWSYIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAW2</accession>
    <name>G0SAW2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Inositol-phosphate phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0048000</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695164.1">
        <property type="nucleotide sequence ID" value="XM_006695101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAW2"/>
    <dbReference type="STRING" id="759272.G0SAW2"/>
    <dbReference type="GeneID" id="18258838"/>
    <dbReference type="KEGG" id="cthr:CTHT_0048000"/>
    <dbReference type="eggNOG" id="KOG2951">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044118_1_1_1"/>
    <dbReference type="OMA" id="PSHHFIG"/>
    <dbReference type="OrthoDB" id="10254945at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000004">
        <property type="entry name" value="Inositol-1-monophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854">
        <property type="entry name" value="INOSITOL MONOPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854:SF39">
        <property type="entry name" value="PROTEIN QUTG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="174"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS19342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="24623" checksum="F6DD6223094D0CD3" modified="2011-10-19" version="1">MSSPSKINEEELDEIYAFAIQLGKDAGKLLMDAARSRFGSGGSMTSQEITEKDNSVDIVTKADEGKVEEFIKVSITQRYPHHAFIGEETYSKLPTRTYLIDPSIPTWCVDPLDGTVNYTHLFPMFCVSIALVLGGEPIIGVIYAPFLNQLFTACRGRGAWLNETLQLPLVRNPIPPMPSNAPQGRAFHNGDRKRGSGENGSGGLETGEGIKLHATGGLNLEVGEEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0SB66</accession>
    <name>G0SB66_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Centrosomin N-terminal motif 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0049070</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695268.1">
        <property type="nucleotide sequence ID" value="XM_006695205.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0SB66"/>
    <dbReference type="GeneID" id="18258945"/>
    <dbReference type="KEGG" id="cthr:CTHT_0049070"/>
    <dbReference type="eggNOG" id="ENOG502QU0H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000791_0_0_1"/>
    <dbReference type="OMA" id="GNILFWP"/>
    <dbReference type="OrthoDB" id="10255000at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012943">
        <property type="entry name" value="Cnn_1N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024545">
        <property type="entry name" value="Mto1-like_Mto2p-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF40">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07989">
        <property type="entry name" value="Cnn_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12808">
        <property type="entry name" value="Mto2_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomin N-terminal motif 1" evidence="5">
        <location>
            <begin position="307"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Mto1-like Mto2p-binding" evidence="6">
        <location>
            <begin position="1308"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="73"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="214"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="378"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="587"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1009"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1211"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1320"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="344"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="415"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="478"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="607"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="955"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1039"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1015"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1293"/>
            <end position="1305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS19446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1364" mass="153220" checksum="9D6DE45061D0B8EE" modified="2011-10-19" version="1">MDEKGGGSNRVSSPSDRGSSLLSGNMPDLRPEPSTMTYESSYLESPSIDNRHADAQAERAVLEHLAEMEASLASPFSPLNSSQNTNHDTFIYDSPTKKPTKRASIVVPTNDDSDNDVTNTEIQAGPVDAGRAPSRSSTTSHRQKRSGSNRSSVSSQGSDSGSSATVGAGGKKPSRPVSRDTNTPTARPSSLASVNSDGEQAVSYRLPDWLRKTEDAEKDAERQAAKQVEKQVEKQVERPSTPTTPKTAGASVLAAPTDTVLARHVSAVKVPDSVAAEYLSKREHDTPLRTTLWGDTYKDPAHSRTLTLKEQGVTIDRLVKENFGLKLKIYFLNERLEKLSDENVKKCIAENVELKTTNQILQRELKLAKRCIKKHEKERQLREAAASSDTVKGAESDNEQGNASDQEAQERDKELIYLREQVELHTTEIQRLEKEKLELAAEKQRMAEVIRTLRDKATERLSQEYDRQEEADVWKDLHEQETARREQADEEIRRLREEIFRLKQEYSTAPSVESSTLIEDLRRESDHLRHENAELRREVGAQSSMLTSRNREIERLHQEIEDLKLAQRRGAPAPSTVDSLLERSASRAGIHERPQSRASGVTRVSALPLDDEERESYEEKLDELRDKINSLRLKNRDLHQQLEAYMNDIEILTDAKNKAEERIATLEEEAQAAARDLMALNAERDDVIQEYEHLEEGYKAVAEENKVYAELVTSLESQVEALQADLDRFRLENEQLAIDKENLAAEHEKLDLEYATLREQYDAYQAKVRELSEMVVRLEDTQASGIREAERLRQDNAALERELEMLEARLLEANEKNNRLTVQLESSQGEISFLREEQEADKMRIGELEASLANVEQVLRDERERVRELNETLASERRQREADSNREKEEVQKIIDELNREAAAAKDEARRLRRNLSNKEVEADNWKEKFFDFDNRIRSALGCLHGTKSAVFEKIADIQRGLEEAVRDLNNAKSTLAEKDRLIKQRDALLESQALETRKLGDMLDKERQAHRATKSQLEASQQAHQHVMRTNSDQDKRIMELEAGRAQDKRKIAQLEASLKEQLTERNTLLLTLWRRLSALCGSDWIHNNSLINGRALPSLESLSSMFPGFAKNLLAAVGTIEGMVASFFTKTKVVQASISKDYQTLQTLLENRTKRIERLESIVRAATAAGLLPIGQSRTLEVDSRMTRVDDMCRQLKVENHTLRAAAEARRAAQAASSSSVPDPAGAESPAPAVPTGPKGKDKVTGAANKVPKSSTKGSLVLPAPATPTRASSGTEALPAVTEDGDPAPTASGSGSLVPSSTTDSKWLLRLRDLEAKLRMEREGRLLDRGEARRRLDASEREMANLRGDLEKEREKSRRAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBQ0</accession>
    <name>G0SBQ0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hyphal anastamosis-8 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0054360</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695771.1">
        <property type="nucleotide sequence ID" value="XM_006695708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBQ0"/>
    <dbReference type="STRING" id="759272.G0SBQ0"/>
    <dbReference type="GeneID" id="18259474"/>
    <dbReference type="KEGG" id="cthr:CTHT_0054360"/>
    <dbReference type="eggNOG" id="ENOG502RFD2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044229_0_0_1"/>
    <dbReference type="OMA" id="WGLVCAI"/>
    <dbReference type="OrthoDB" id="5420724at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42069">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-8 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42069:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="428"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS18826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="54235" checksum="1CA15EB99AD1E227" modified="2011-10-19" version="1">MAPDEKKRPAALKLTPARSQSVESVSSTDSSSTSSSLAKPPRTPRFAEATTIVSPIEPPTNNPFSEKAQPGDVGFGYIGNSESRDAAVPMTPKSPLKSALRAPGSNGRAIPNPLSPTFKEEQILSEKEKRVEKDQKRDLMRVRMAKLALRGVSFSCSLIILSMLAASFSIFNATKALPSLSNLPTWAENTKVWPQIVVLVCACISLCICITIFIMYCRGGHRRAEKVGVYYTLFAVGWFIFSMVMWAVAAGVLQFSRNNSNNKDLWGWACVENRRSTIQGQAQNVDYDLVCRLQDWTLICIIIELVIEVISISLYSIVFYRYWTKRKLHKSMDMRDKARSDFYLAQLRSQSAPNTPGFPKSPTFSQYALSPRFPPSTYKNLAEIDNDDDSTKGSVNPFTPGGKNLVVPTSSFANSNFKLQAPPPKANPATPSAPKSLSPTTTTPPIPAVQQQVHVNAPAPMAEGEKQYEAVPIPSAYSGQAIKSPVQATFNVQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBZ2</accession>
    <name>G0SBZ2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="4">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0055310</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Esterase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the carbohydrate esterase 1 (CE1) family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695863.1">
        <property type="nucleotide sequence ID" value="XM_006695800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBZ2"/>
    <dbReference type="ESTHER" id="chatd-g0sbz2">
        <property type="family name" value="Esterase_phb"/>
    </dbReference>
    <dbReference type="GeneID" id="18259569"/>
    <dbReference type="KEGG" id="cthr:CTHT_0055310"/>
    <dbReference type="eggNOG" id="ENOG502QTDU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027551_1_1_1"/>
    <dbReference type="OMA" id="RMYIYVP"/>
    <dbReference type="OrthoDB" id="2425929at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010126">
        <property type="entry name" value="Esterase_phb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050955">
        <property type="entry name" value="Plant_Biomass_Hydrol_Est"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01840">
        <property type="entry name" value="esterase_phb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037:SF5">
        <property type="entry name" value="FERULOYL ESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037">
        <property type="entry name" value="UNNAMED PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10503">
        <property type="entry name" value="Esterase_PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="1 4" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029036377" description="Carboxylic ester hydrolase" evidence="4">
        <location>
            <begin position="20"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="6">
        <location>
            <begin position="332"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="297"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS18918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="368" mass="39292" checksum="5C61CEC0FC451C3B" modified="2011-10-19" version="1">MKLNNLASSLLSLVAVADAASLTQVTNFGSNPSGARMYIYVPDRLQTNPPILTAIHYCTGTANAFYTGTPYARLADQYGFIVIYPESPYSGSCWDVSSRATLTRDGGGSSTSIAQMVRWAIERYNADRNRIFVAGTSSGAMMTNVLAATYPDLFKAAAAYAGVPAGCFYTGTVAGWNSTCANGQSIASQQVWAQTALDMYPGYTGPRPKMMIYHGSADTTIYPQNFNETMKQWCGVFGYTYGSPQQTLANTPSAGYTKYVYGENLVGIYGSGVTHNIPVNGENDLNWFDGIKGGSSTPTTTAVTSSVPSTTLSTSTRTTTTSSTSAPTPTGCTSQRWGQCGGIGWTGCTTCASPWTCTKLNDWYYQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCT2</accession>
    <name>G0SCT2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Endoplasmic reticulum transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0058330</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the BCAP29/BCAP31 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696153.1">
        <property type="nucleotide sequence ID" value="XM_006696090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCT2"/>
    <dbReference type="STRING" id="759272.G0SCT2"/>
    <dbReference type="GeneID" id="18259871"/>
    <dbReference type="KEGG" id="cthr:CTHT_0058330"/>
    <dbReference type="eggNOG" id="KOG1962">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087648_0_1_1"/>
    <dbReference type="OMA" id="EMGLFML"/>
    <dbReference type="OrthoDB" id="435607at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008417">
        <property type="entry name" value="BAP29/BAP31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040463">
        <property type="entry name" value="BAP29/BAP31_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041672">
        <property type="entry name" value="Bap31/Bap29_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701">
        <property type="entry name" value="BCR-ASSOCIATED PROTEIN, BAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701:SF20">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05529">
        <property type="entry name" value="Bap31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18035">
        <property type="entry name" value="Bap31_Bap29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="BAP29/BAP31 transmembrane" evidence="13">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Bap31/Bap29 cytoplasmic coiled-coil" evidence="14">
        <location>
            <begin position="166"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS19208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="216" mass="25109" checksum="C116D260022E2FB5" modified="2011-10-19" version="1">MTLYYTLVFLLLVAEIALFMLLILPLPFNVRRKLFTFISENPIVAKFQYWLKITFVFILVLFIDSVNRVYRVQQELAATSEAHGNGGHAIHGHERLEVQARKFYSQRNMYLCGFTLFLSLILNRTYILILEVLRLEEKLKQYEGNSASKRQGKSSSEKQSAENKDEEIARLKRELALREQDLATLKKQAAGLHREYDSLAEKYSKTQDDGTPKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCV5</accession>
    <name>G0SCV5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0058510</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696171.1">
        <property type="nucleotide sequence ID" value="XM_006696108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCV5"/>
    <dbReference type="STRING" id="759272.G0SCV5"/>
    <dbReference type="GeneID" id="18259889"/>
    <dbReference type="KEGG" id="cthr:CTHT_0058510"/>
    <dbReference type="eggNOG" id="KOG1827">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012767_0_0_1"/>
    <dbReference type="OMA" id="LWTNAYF"/>
    <dbReference type="OrthoDB" id="6017at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000083">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037382">
        <property type="entry name" value="Rsc/polybromo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054551">
        <property type="entry name" value="RSC4_Ig-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062:SF19">
        <property type="entry name" value="PROTEIN POLYBROMO-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062">
        <property type="entry name" value="SWI/SNF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22994">
        <property type="entry name" value="RSC4_Ig_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="65"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="309"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="183"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="398"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="185"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="209"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="430"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="468"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="492"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS19226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="679" mass="73975" checksum="84D8D4BBD94B4796" modified="2011-10-19" version="1">MDNKRKATGAAGADIDGDGDDRASKRRKVPGPPSDYNLLEGETPESTTAYGLHFLETIRRTKDKSGRLVASYFEDLIPHEGNEEYYRRIRMPLSLKIIEQKLHNQEFKNLSELESYFKRMVTNAKEFYPKNSEIYEDAERVRKALSNYMTKTNPAYKLNPGYSCQAAPIPDDLASDAHAPAAIGRTQSSSGTNGKSRPTNSKVKKEPEAQEEDAEGDEDAQGDEEQAGGDSNDGEEEDDGPRKIVIRRRGTGRPTRGSTEPSKKHDKAGRVRADHEYEGVPYKGLTFQQAQEKIVEELIRKPDGPDPYFLDFINLPPRSYKDYFAVIQNPLSLKGLQKLVKGIHGRQPATGISDFKTWAQFEEKASLLWENAHFYNEEGSECFYKELNEAKAVVQEPPQPKIKLKMAPGQDGSTGTSKKITIHVGGSRGSATASPAPQTASSVDGSIDRSGTPAGSTAGASFDKGKLTGAAPSPSPAPGTAGQPSPAVTPRLNGSTPATINGANGMPSGQAQLQNGQSASSTGPLLYDSKYRAPGRGLADSLLPSVLIRTHPGVVMDRRFRVELPAHPKEAQQNISLHIPAAHHRLQLIPRLPPFEQQGRAYRVFVTINGQMVGRATPLPIPDDPLPRDAMVFEIGLGLTTNIIAVTVVASLPKGQKLPNGADCEVERMTIYAQLMRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0SD22</accession>
    <name>G0SD22_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein bL27m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0050500</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695397.1">
        <property type="nucleotide sequence ID" value="XM_006695334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SD22"/>
    <dbReference type="STRING" id="759272.G0SD22"/>
    <dbReference type="GeneID" id="18259088"/>
    <dbReference type="KEGG" id="cthr:CTHT_0050500"/>
    <dbReference type="eggNOG" id="KOG4600">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062495_0_1_1"/>
    <dbReference type="OrthoDB" id="1867012at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000042">
        <property type="entry name" value="50S ribosomal protein L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_bL27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL27M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS18452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="434" mass="48741" checksum="CCAF20352F48D6B5" modified="2011-10-19" version="1">MLSQQKTSPLQPTQCRSPNRRQPNSVQSPGPLNPIAAAISTSRSLALPSALIFSVPVAARNVRERQAMQLARLQRPFQRVAGAVASASRPLGALSRPTTTSLEDRFASLRIASPTEINAAVQGKRYATVKSQGAYKLKSKKTIPKKLGAKRTGDQYVLPGNIIYKQRGTVWHPGENTIMGRDHTIHAAVAGYVKYYRDPHRHPGRQYIGVAFNRDDKLPYPPGKRSEEVISPSGIPLTVTRLPESEQSTESEDSTTTGVSVTAQTTVTAKPKLPIHLRRRIPLKDGNSVIARLIQQKLRARAITKAKQDAWRLQQQKELEARMNTRVFRLQDDYSYRETNWEIGRLIGDAGTIPGTEKTESRRARMRSRRKKRAAYFRELKARRVAKARRREESKRRLREKRAVLLAQRREATTTVKATNEAVKVAAEKNKVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDB2</accession>
    <name>G0SDB2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0051150</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695458.1">
        <property type="nucleotide sequence ID" value="XM_006695395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDB2"/>
    <dbReference type="STRING" id="759272.G0SDB2"/>
    <dbReference type="GeneID" id="18259153"/>
    <dbReference type="KEGG" id="cthr:CTHT_0051150"/>
    <dbReference type="eggNOG" id="ENOG502S8MB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080764_1_0_1"/>
    <dbReference type="OMA" id="GWIHVSD"/>
    <dbReference type="OrthoDB" id="5397701at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37331">
        <property type="entry name" value="YALI0F11671P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37331:SF1">
        <property type="entry name" value="YALI0F11671P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS18513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="195" mass="20380" checksum="41CE4C181305D2DB" modified="2011-10-19" version="1">MATLFRSISRLSPPMNGQSRIRTITTLSSNPSIKVFPHPSKPNTHLLTYLETNPPNPSLAIGTTTTVPPTPNSFRENPRFLTILNDVLAKHAANDPDLKAQAQAFASPGGFSFIQAGRSGRGGSGGAGGASAEGGAGGAGVGGWVHLSDTRNPPEFGRIAWPEDIFGSVEVNGKGEIIGNYQPSGTYRIITPNGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDF6</accession>
    <name>G0SDF6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0051610</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily. S-2-haloalkanoic acid dehalogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695502.1">
        <property type="nucleotide sequence ID" value="XM_006695439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDF6"/>
    <dbReference type="STRING" id="759272.G0SDF6"/>
    <dbReference type="GeneID" id="18259199"/>
    <dbReference type="KEGG" id="cthr:CTHT_0051610"/>
    <dbReference type="eggNOG" id="ENOG502S19E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_3_0_1"/>
    <dbReference type="OMA" id="WHRLNPW"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019120">
        <property type="term" value="F:hydrolase activity, acting on acid halide bonds, in C-halide compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006328">
        <property type="entry name" value="2-HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01493">
        <property type="entry name" value="HAD-SF-IA-v2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01428">
        <property type="entry name" value="HAD_type_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF3">
        <property type="entry name" value="HALOACID DEHALOGENASE, TYPE II (AFU_ORTHOLOGUE AFUA_2G07750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS18557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="272" mass="30106" checksum="5A89A136E5274F38" modified="2011-10-19" version="1">MTSKSPLSGIKALTFDVFGTTVSWREAVANALAEAARNKLAFLKSQEITPDPEVIKGLERLTTQKGSAALAAQWRASYSTFTRGFRKGEMEWKTVDDHHRDSLASLLASEPWNVLTVFTPSELQDLSLIWHRLPAHPDARPGLQALSSLGLTTATLTNANHILLHNLITFSSLPFHYLFCAEDFYAYKPSPEVYLGACKAMGLQPGEVAMVAAHLGDLDAARGIGMKTVYVEREGEEEWDEQRRREARGWVDFWVAEGEGGFGKVERGIRGV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2024-10-02" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDW4</accession>
    <name>EZH2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone-lysine N-methyltransferase EZH2</fullName>
            <ecNumber evidence="5 6">2.1.1.356</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Enhancer of zeste homolog 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">EZH2</name>
        <name type="ORF">CTHT_0053230</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2016" name="Science" volume="354" first="1543" last="1543">
            <title>Comment on 'Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2'.</title>
            <authorList>
                <person name="Zhang Y."/>
                <person name="Justin N."/>
                <person name="Wilson J.R."/>
                <person name="Gamblin S.J."/>
            </authorList>
            <dbReference type="PubMed" id="28008037"/>
            <dbReference type="DOI" id="10.1126/science.aaf6236"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2017" name="Elife" volume="6" first="0" last="0">
            <title>Conserved RNA-binding specificity of polycomb repressive complex 2 is achieved by dispersed amino acid patches in EZH2.</title>
            <authorList>
                <person name="Long Y."/>
                <person name="Bolanos B."/>
                <person name="Gong L."/>
                <person name="Liu W."/>
                <person name="Goodrich K.J."/>
                <person name="Yang X."/>
                <person name="Chen S."/>
                <person name="Gooding A.R."/>
                <person name="Maegley K.A."/>
                <person name="Gajiwala K.S."/>
                <person name="Brooun A."/>
                <person name="Cech T.R."/>
                <person name="Liu X."/>
            </authorList>
            <dbReference type="PubMed" id="29185984"/>
            <dbReference type="DOI" id="10.7554/elife.31558"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DOMAIN</scope>
        <scope>RNA-BINDING</scope>
        <scope>MUTAGENESIS OF 266-ASP--HIS-272 AND 284-ARG--TYR-288</scope>
    </reference>
    <reference evidence="13 14 15" key="4">
        <citation type="journal article" date="2015" name="Science" volume="350" first="aac4383" last="aac4383">
            <title>Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2.</title>
            <authorList>
                <person name="Jiao L."/>
                <person name="Liu X."/>
            </authorList>
            <dbReference type="PubMed" id="26472914"/>
            <dbReference type="DOI" id="10.1126/science.aac4383"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DOMAIN</scope>
        <scope>SUBUNIT</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>MUTAGENESIS OF PRO-325; HIS-326; ASP-329; LEU-350 AND ARG-839</scope>
    </reference>
    <reference evidence="12 17 18" key="5">
        <citation type="journal article" date="2017" name="J. Biol. Chem." volume="292" first="13323" last="13332">
            <title>Polycomb repressive complex 2 in an autoinhibited state.</title>
            <authorList>
                <person name="Bratkowski M."/>
                <person name="Yang X."/>
                <person name="Liu X."/>
            </authorList>
            <dbReference type="PubMed" id="28607149"/>
            <dbReference type="DOI" id="10.1074/jbc.M117.787572"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.11 ANGSTROMS) OF 191-950 IN COMPLEX WITH S-ADENOSYL-L-METHIONINE AND ZN(2+)</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>MUTAGENESIS OF GLU-840; LYS-852 AND PHE-922</scope>
    </reference>
    <reference evidence="19 20 21" key="6">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="9092" last="9092">
            <title>An evolutionarily conserved structural platform for PRC2 inhibition by a class of Ezh2 inhibitors.</title>
            <authorList>
                <person name="Bratkowski M."/>
                <person name="Yang X."/>
                <person name="Liu X."/>
            </authorList>
            <dbReference type="PubMed" id="29904056"/>
            <dbReference type="DOI" id="10.1038/s41598-018-27175-w"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.28 ANGSTROMS) OF 191-950 IN COMPLEX WITH ZN(2+)</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <comment type="function">
        <text evidence="5 6 7 8">Catalytic subunit of the of the Polycomb Repressive Complex 2 (PRC2), a histone H3 lysine methyltransferase responsible for generating mono-, di-, and tri-methylation on Lys27 (H3K27me1, H3K27me2 and H3K27me3) (PubMed:26472914, PubMed:28607149, PubMed:29904056). The tri-methylated form is known to be critical in gene repression, and its proper placement is essential in defining repression patterns during development (PubMed:26472914, PubMed:28607149, PubMed:29904056). The PRC2 complex interacts with thousands of RNA species in vivo, but the physiological function of RNA binding has still to be determined (PubMed:29185984).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60292"/>
            <dbReference type="Rhea" id="RHEA-COMP:15535"/>
            <dbReference type="Rhea" id="RHEA-COMP:15548"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.356"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5 6">
            <dbReference type="Rhea" id="RHEA:60293"/>
        </physiologicalReaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="5 6 8">The end product of PRC2 catalysis, H3K27me3, interacts with EED to stimulate the enzymatic activity of PRC2 allosterically (PubMed:26472914). The enzymatic activity of PRC2 is regulated in a very complex manner and PCR2 can adopt different stages including the autoinhibited (A); SAM-bound autoinhibited (A'), basal (B), and H3K27me3-stimulated (S) stages (PubMed:28607149). Actictivity is inhibited by pyridone inhibitors such as GSK126 (PubMed:29904056).</text>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <KM evidence="6">13 uM for H3K27me0 peptide substrate</KM>
            <KM evidence="6">29 uM for S-adenosyl-L-methionine</KM>
        </kinetics>
    </comment>
    <comment type="subunit">
        <text evidence="5 6">Component of the polycomb repressive complex 2 (PRC2) that consists of four core subunits icluding EZH2, EED, SUZ12, and RBBP4, among which EZH2 is the catalytic subunit and which minimally requires EED and SUZ12 for catalysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5 7">Ten structurally and functionally discrete domains are dispersed across the entire active complex and compose an extended structural scaffold to accommodate juxtaposed EED and SUZ12. The N terminus forms an intramolecular interaction with the SANT1-like (SANT1L) domain and is referred to as the SANT1L-binding domain (SBD). The EED-binding domain (EBD) is found next to the SBD in the current structure, where the EBD similarly occupies a surface groove across the bottom face of the EED WD40 domain. Continuation of the EBD on the side face of EED leads to the beta-addition motif (BAM), consisting of three beta strands that are added to the beta-propeller fold of the WD40 repeats of EED. The BAM domainis involved in RNA-binding. Following the BAM, a loop region migrates away from the EED surface, extends to the back of the SET domain of the catalytic moiety, and is referred to as SET activation loop (SAL). The buried SAL emerges from between the SET domain and SUZ12 to directly connect to the stimulation-responsive motif (SRM), which sits on the stimulating peptide at the center of the top face of EED and forms a sandwich-like assembly with EED and the H3K27me3 peptide. Following the SRM, the SANT1L domain adopts a helix bundle structure and binds to the SBD. Together, the SBD, EBD, BAM, SAL, SRM, and SANT1L regions complete the belt-like structure of EZH2 that surrounds EED (PubMed:26472914). Entering the catalytic moiety, the SANT2-like (SANT2L) domain is linked to the SANT1L domain through the motif connecting SANT1L and SANT2L (MCSS), which harbors two helices, a zinc-binding motif, and a beta hairpin, and interacts with multiple surfaces. The SANT2L domain coordinates a zinc ion as well and is analogous to the SANT2 domain of human Ezh2 based on secondary-structure prediction. The CXC domain contains a Zn3Cys8His and a Zn3Cys9 cluster. The SET domain is positioned above EED and SUZ and adjacent to the SRM. The overall structure of the active ternary complex, and in particular the location of the catalytic domain, underlies allosteric modulation of the enzyme activity through various functional surfaces within the complex (PubMed:26472914, PubMed:29185984).</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. EZ subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.356" evidence="5 6"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695660.1">
        <property type="nucleotide sequence ID" value="XM_006695597.1"/>
    </dbReference>
    <dbReference type="PDB" id="5BJS">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.19 A"/>
        <property type="chains" value="B=191-950"/>
    </dbReference>
    <dbReference type="PDB" id="5KJH">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.27 A"/>
        <property type="chains" value="B=191-950"/>
    </dbReference>
    <dbReference type="PDB" id="5KJI">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.71 A"/>
        <property type="chains" value="B=191-950"/>
    </dbReference>
    <dbReference type="PDB" id="5KKL">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.94 A"/>
        <property type="chains" value="B=191-950"/>
    </dbReference>
    <dbReference type="PDB" id="5M5G">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.27 A"/>
        <property type="chains" value="B=191-952"/>
    </dbReference>
    <dbReference type="PDB" id="5TQR">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.57 A"/>
        <property type="chains" value="B=191-950"/>
    </dbReference>
    <dbReference type="PDB" id="5VK3">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.11 A"/>
        <property type="chains" value="B=191-950"/>
    </dbReference>
    <dbReference type="PDB" id="5WF7">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.50 A"/>
        <property type="chains" value="B=191-950"/>
    </dbReference>
    <dbReference type="PDB" id="5WFC">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.28 A"/>
        <property type="chains" value="B=191-950"/>
    </dbReference>
    <dbReference type="PDB" id="5WFD">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.65 A"/>
        <property type="chains" value="B=191-950"/>
    </dbReference>
    <dbReference type="PDBsum" id="5BJS"/>
    <dbReference type="PDBsum" id="5KJH"/>
    <dbReference type="PDBsum" id="5KJI"/>
    <dbReference type="PDBsum" id="5KKL"/>
    <dbReference type="PDBsum" id="5M5G"/>
    <dbReference type="PDBsum" id="5TQR"/>
    <dbReference type="PDBsum" id="5VK3"/>
    <dbReference type="PDBsum" id="5WF7"/>
    <dbReference type="PDBsum" id="5WFC"/>
    <dbReference type="PDBsum" id="5WFD"/>
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            <position position="881"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 15 17">
        <location>
            <position position="881"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 15">
        <location>
            <position position="926"/>
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        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
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    <feature type="binding site" evidence="13 14 16">
        <location>
            <position position="927"/>
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        <ligand>
            <name>S-adenosyl-L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
        </ligand>
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    <feature type="mutagenesis site" description="Causes significant reduction in RNA-binding but does not affect the catalytic activity." evidence="7">
        <original>DVKFKQH</original>
        <variation>AVAFAQA</variation>
        <location>
            <begin position="266"/>
            <end position="272"/>
        </location>
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    <feature type="mutagenesis site" description="Does not affect RNA-binfing but leads to a reduction in catalytic activity." evidence="7">
        <original>RRFQY</original>
        <variation>GGSGG</variation>
        <location>
            <begin position="284"/>
            <end position="288"/>
        </location>
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    <feature type="mutagenesis site" description="Impairs allosteric activation by H3K27me3." evidence="5">
        <original>P</original>
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        <location>
            <position position="325"/>
        </location>
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    <feature type="mutagenesis site" description="Impairs allosteric activation by H3K27me3." evidence="5">
        <original>H</original>
        <variation>A</variation>
        <location>
            <position position="326"/>
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    <feature type="mutagenesis site" description="Impairs allosteric activation by H3K27me3." evidence="5">
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            <position position="329"/>
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    <feature type="mutagenesis site" description="Impairs allosteric activation by H3K27me3." evidence="5">
        <location>
            <position position="350"/>
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    <feature type="mutagenesis site" description="Impairs allosteric activation by H3K27me3." evidence="5">
        <original>R</original>
        <variation>D</variation>
        <location>
            <position position="839"/>
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    <feature type="mutagenesis site" description="Leads to loss of the autoinhibition and enhanced catalysis toward all the methylation states of H3K27; when associated with D-852." evidence="6">
        <original>E</original>
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            <position position="840"/>
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    <feature type="mutagenesis site" description="Leads to loss of the autoinhibition and enhanced catalysis toward all the methylation states of H3K27; when associated with A-840." evidence="6">
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            <position position="852"/>
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    <feature type="mutagenesis site" description="Leads to a complete loss of activity." evidence="6">
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    <feature type="helix" evidence="27">
        <location>
            <begin position="199"/>
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    <feature type="helix" evidence="27">
        <location>
            <begin position="212"/>
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    <feature type="turn" evidence="27">
        <location>
            <begin position="243"/>
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    <feature type="strand" evidence="23">
        <location>
            <begin position="260"/>
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    <feature type="strand" evidence="27">
        <location>
            <begin position="264"/>
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    <feature type="turn" evidence="27">
        <location>
            <begin position="274"/>
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    <feature type="strand" evidence="27">
        <location>
            <begin position="278"/>
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    <feature type="strand" evidence="27">
        <location>
            <begin position="284"/>
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    <feature type="strand" evidence="27">
        <location>
            <begin position="291"/>
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    <feature type="helix" evidence="23">
        <location>
            <begin position="335"/>
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    <feature type="helix" evidence="27">
        <location>
            <begin position="361"/>
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    <feature type="helix" evidence="27">
        <location>
            <begin position="378"/>
            <end position="380"/>
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    <feature type="helix" evidence="27">
        <location>
            <begin position="381"/>
            <end position="388"/>
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    <feature type="helix" evidence="27">
        <location>
            <begin position="395"/>
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    </feature>
    <feature type="helix" evidence="27">
        <location>
            <begin position="406"/>
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    <feature type="turn" evidence="27">
        <location>
            <begin position="409"/>
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    <feature type="helix" evidence="27">
        <location>
            <begin position="414"/>
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    <feature type="helix" evidence="27">
        <location>
            <begin position="431"/>
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    <feature type="helix" evidence="27">
        <location>
            <begin position="459"/>
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    <feature type="turn" evidence="27">
        <location>
            <begin position="467"/>
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    <feature type="helix" evidence="27">
        <location>
            <begin position="470"/>
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    <feature type="helix" evidence="27">
        <location>
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    <feature type="helix" evidence="27">
        <location>
            <begin position="501"/>
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    <feature type="turn" evidence="27">
        <location>
            <begin position="509"/>
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    <feature type="strand" evidence="23">
        <location>
            <begin position="514"/>
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    <feature type="strand" evidence="27">
        <location>
            <begin position="519"/>
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        <location>
            <begin position="523"/>
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            <begin position="532"/>
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    <sequence length="1522" mass="169207" checksum="89016EB11950E231" modified="2011-10-19" version="1">MSPARGDANASVARASGGSSNGAVTADEVVVQVDDSDENRENLRDRDRADKLEKLEKDAHARSQTQTQVQAPPVTVSSFRSANGDAIRAYRSETALTMKPRPRGSTSSTPTTTIPPLRPGRPSSPESPSLKRLSPRYSPTILASRTSRFSNRTGIRDSQSPSPILADEMVGRESLRKRPATSNTPAPKTPTPKNTEWTVDKIASALSVLAEEVPQNHSRLVNFLLEETEKRAPQPRHLSKTDPFAHMKSKAIDANRPRPEGVPTMDVKFKQHSGEYGKSRNSGRRFQYPVVCIKPDREPVPPYRFHHAEIRKNILALNSQLNFVPHLRDVDPNSAEEQKYSAWLMDLENLDSKSGFKIQPRSQKIAKRAQAEYAATLAPYLEPWLRKLNIEGCTKSNLIRFMASQPESDDSMTPQQKSNLLDTYSDDMGSPQAVRNASMFTEAWDRVFNDQSKLRRVALRDILMLDKNVEPIFDNKRAKDAPGSQKPPDEALMQKVIDALGSYTTLGCLICFSHDCEHGEIERDNQKRCFSLEEIGGLMPSLRRKWAAQIEQRQKTEGGSANAPPAHPPCRNECYRIHGTGDPNQQVPPWSENEVGTLEWMFATIGYSQTLRPECFVGAILGRPCWDVHRKLQELDLRLPPVEPRTIPKQKSLPWYDRRKKQLMSDWADATITHEHAVRELFAPCHHDGPCTAANGCPCASAGTHPVLCERFCLCTAEECPLKFTGCACHSSGKTCLQRQREGRPCICVQLNRECDPTLCKGCGARERADPENAYDEVLHSTGCQNVALQRGAAKAVVLGKSQLEACGYGLFAAEDIEEGEFVIEYTGELISHDEGVRREHRRGDVFDEENKVSYLFTLLEQEGIWVDAAIYGNLSRYINHATDGNIMPKIMYVNHEWRIKFTAIKDIKAGEELFFNYGDNFPNLTKKLVERNEQSGAETTPQQPKRANGAATQRATARKTTSKAKGEGIGFDDDDRDGNDSDPDDLWMGDQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQAQKPQPSTSHQPQSRAERSSTETGSEEISPDKQLRRENHDAQRQLLHQFQQQEQQQQQQQQQQQQQQTLPRKEPKKEELEEEIDLDAPRRSRLKRRLEALKGDSSSGGSANEQPPVKKPSRRGGARPGAGRKPKHRPPGAKGKDSKGKKGPSSSAGATTGAGSGESSGVNETGEEEVAVNGKSDSKDEAKEEETDKEKEEDEKVNEKDREKGRDSLSSPTEEPIAFLPVTKSAPSPAKKQASSPTKISDSNRTTSKNTSSNNNNNTNNNNNNNNNEFPSPVISPRKTRSSDHLTNSQPAALSPSATTRKRKASDLTSDTHLSAAGKGSDPSTMTTTTTTTTTTTSSSSSSSSSSSSSSSSSKAQPILEEKGDDDDENNEPITSPLKRQKTSSSLSSSHSMSVFSEAKEGVNGAVPGSGRNLRSSGVKVDSSGLNSTSLSQERGEKHEKHEKEKPKEKKGEKERERERDRSEEADEELLPMDRSMRKRQKPARYRDEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEC5</accession>
    <name>G0SEC5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Carboxypeptidase</fullName>
            <ecNumber evidence="15">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CTHT_0063260</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preferential release of a C-terminal arginine or lysine residue.</text>
            <dbReference type="EC" id="3.4.16.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="15"/>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696633.1">
        <property type="nucleotide sequence ID" value="XM_006696570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEC5"/>
    <dbReference type="STRING" id="759272.G0SEC5"/>
    <dbReference type="MEROPS" id="S10.007"/>
    <dbReference type="GeneID" id="18260364"/>
    <dbReference type="KEGG" id="cthr:CTHT_0063260"/>
    <dbReference type="eggNOG" id="KOG1282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008523_11_0_1"/>
    <dbReference type="OMA" id="EMADQFV"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000121">
        <property type="entry name" value="Carboxypeptidase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF190">
        <property type="entry name" value="PHEROMONE-PROCESSING CARBOXYPEPTIDASE KEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4 15 18" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0732">Signal</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409163" description="Carboxypeptidase" evidence="15">
        <location>
            <begin position="36"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="526"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="478"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="554"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="480"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="569"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="635"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGS18302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="650" mass="72855" checksum="575E9F5F111CD2E3" modified="2011-10-19" version="1">MTPSRSWMRALMGSLRMPTAVAALLLSCAASLAAAEKSAADYFVHSLPGAPEEPPIKMHAGHIEITPEHNGNIFFWHFQNRHIANRQRTVIWLNGGPGCSSEDGALMEIGPYRLKDDHTLVYNEGSWNEFANVLFVDNPVGTGYSYVDTNAYVHELDEMASQFVTFLEKWYALFPEYEHDDLYIAGESYAGQHIPYIAKRILERNKQPNIKYKWNLKGLLIGNGWISPREQYEAYLNYAFEKGLVKKGSDIANKLEVQLRICQKELAVGPAAVDNPDCEKILQDMLMLTSNVEKGQRMCYNMYDVRLKDTYPSCGMNWPPDLKFVTPYLRRTDVVNALHVNPNKVTGWVECSGFVSSNFRPVKSKPSIDLLPDLLAEIPILLFSGAEDLICNHLGTEALISNMVWNGGRGFELSPGTWAPRREWTFEGETAGFWQEARNLTYVVFYNASHMVPFDFPRRTRDMLDRFMGVDISSIGGKPTDSRLDGEKGPETTVGGAAGNSTTAKQEEKEKLDAAKWEAYRRSGEIVLVIVIIAAGAWGYFVWKDRRNKRHEGYQGLAGGENGSAGFMAHHRRQSSLRQQHRRRDLEAGDFDETQLDSLHVKSPTEGNNAAAGRESREMYSVGGVSEDESGDEEAVNKGKGKERAENGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0SED0</accession>
    <name>G0SED0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative transcriptional coactivator HFI1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0063310</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696638.1">
        <property type="nucleotide sequence ID" value="XM_006696575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SED0"/>
    <dbReference type="STRING" id="759272.G0SED0"/>
    <dbReference type="GeneID" id="18260369"/>
    <dbReference type="KEGG" id="cthr:CTHT_0063310"/>
    <dbReference type="eggNOG" id="ENOG502RX84">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038277_1_0_1"/>
    <dbReference type="OMA" id="EMAFTRG"/>
    <dbReference type="OrthoDB" id="10264870at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024738">
        <property type="entry name" value="Hfi1/Tada1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21277">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21277:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12767">
        <property type="entry name" value="SAGA-Tad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS18307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="485" mass="52079" checksum="76C302BA2009B7D7" modified="2011-10-19" version="1">MVDINPAALSRPSIGLSTPSFPGKSGSINVSVPSSASASASASSAHSKPQKTSLVPPRIDLEPIYTALKAAIGAEQWPVYKETLTNFLIGRLNQAELSERIDPILASQDGQKEHLHNQLIAAIYANVTREMPDPGLAPWVSANDKPTTAQTKPVTGDANERRLKGEVMQLPARDRRRIKELAHNDFDPYDALANVLMEHARAKPPKIAEPPASAGGLKMNFDLEIRKRYAQPLAVESGEFPDTSNIESRMLPFCYEAGLSSGHAPDAAQFMSIATETFIKEVMSAIFSRTRSNGPGDSGSAGFGLGSGWIQTHRYRKQLAKEEEAFQRGEISRDKMGLLPVEAKAASERGPLGMADVRLALEMGDCGLAGFPVIVKSVIYGWREGELENWEDYTYVDPSRPDGIAIPSRGDGDVEMGGVGVNGVVKGEPEPQQQPLANGVHDVDAMDIDGVSVAGGAANEIWWEGAEPETSDLLNAVLDSCLAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEE9</accession>
    <name>G0SEE9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0063500</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696657.1">
        <property type="nucleotide sequence ID" value="XM_006696594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEE9"/>
    <dbReference type="STRING" id="759272.G0SEE9"/>
    <dbReference type="GeneID" id="18260388"/>
    <dbReference type="KEGG" id="cthr:CTHT_0063500"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_606919_0_0_1"/>
    <dbReference type="OMA" id="HTPLMEV"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000374">
        <property type="entry name" value="3-oxoacyl-(Acyl-carrier-protein) reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019191">
        <property type="entry name" value="Essential_protein_Yae1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF111">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_1G10100)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09811">
        <property type="entry name" value="Yae1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="8"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="229"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="346"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="470"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="250"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="384"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="487"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS18326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="509" mass="54791" checksum="5DD15DE220EE55D9" modified="2011-10-19" version="1">MSRPLEGKLAIVTGSSRGVGAAIATNLASKGANIVLNYTSPSSTPLASSLAQKLSEQHNIHVFPIPVDLSSPSGPATLISLVREHFTTHFPSKPFQIDILINNAGIARNAPIENVTIEDFEATYRTNVLAPLLLVQAALPYLPNDRSGRIVNISSVSSSCGFVTQSVYGGSKAALEAMTRTWARELSSRATVNAVNPGPVEGPMYRANPPQFLEGIKGWVMHTPLMEVTEQDGNESSRMTTTSPSRSQTLSTQPQPSIPTVNNATVSEVNDTADLFDDLLTLEDRFYNQGYEQGLVDGIAAGRAEGRQIGLERGFQRFLEAGRLQGKAIVWACRLRAAQKIQGKDGVGEGIKRNGVEAGPREGDREGQTSSQQPTLTSTKEDQLSSPTTSSKPNDSSNSQEYIPPSRIPLPPLISSNPRIERHITSLYALSETESLSVENTDEAVDAFDGRMKRAQGKVKLIERIIHEEKITGTNGEGSTNGGQKGRRTEIEEGRDGNAGRCSSQTRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEU1</accession>
    <name>G0SEU1_CHATD</name>
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        <submittedName>
            <fullName evidence="3">Putative chitin synthase regulatory factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0059700</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS17957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006696225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEU1"/>
    <dbReference type="STRING" id="759272.G0SEU1"/>
    <dbReference type="GeneID" id="18260008"/>
    <dbReference type="KEGG" id="cthr:CTHT_0059700"/>
    <dbReference type="eggNOG" id="KOG1550">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_126_2_1"/>
    <dbReference type="OMA" id="GSHMRAP"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF1">
        <property type="entry name" value="CHITIN SYNTHASE REGULATOR SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
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        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
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        <property type="entry name" value="HCP-like"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="423"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="745"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="124"/>
            <end position="155"/>
        </location>
    </feature>
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        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
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        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
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        <location>
            <begin position="269"/>
            <end position="283"/>
        </location>
    </feature>
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        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="326"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="763"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="775" mass="84441" checksum="7A5B0E1DE8E3E62D" modified="2011-10-19" version="1">MAAVGSAPPSSPTSPASPTSPVHRKPLPHHGLSPIERYDWGENLKPGSGVPDSSPRIRQPPMSPVKVNFQPEDWARPSAGTIETHIPHAGPIPAPVYERPLPKSPEAPTPPPHTPQQYGAEQRQCQAYQPYNPQQQPWQQYSQPQQPSQIPAAAQNYVPGAENSLSPTTAVTPASNGVRAPQPNGPVKRNSRESDSTESTSQQPTSAESSATTSDSSMSGVLDCADNQDNKSADASIESVPIDENAPPPEPVQPLQYHHQAFLPRPPSLTDQDPRAQSSSNLETGAAVNRHLTPNAKYMRRSSLPRPQSAYSVTSEYGVRGRSPNLYGNSQYRSPSSTRRSPDVRPSSYVELLSMPYPQQAPAPISMDNSQLRSVVGSNASLLSTEKTLEMYRQNVKKTNDFATLYSFAVFLIATAQEMGFDPAEPHKQQRTKSPKPDGGSNGATSSSPYDLVREARAILQKLSNNGYPFAQYYLADGYASGLFSKGKEDYNSAFPLFVLAAKHGHAESAYRTALCYEFGWGCRKDPAKAVQFLRSAASKRHPGAMTRLGVACLSGDLGEKRYREGIKWLKLAAEAADSIYNAAPYHLGCLYEHGYGDDIFQDESYAAELFTQAAQLGHPEANYRMGDAYEHGKLNCPRDPALSVHFYTGAAERGHPAAMMGLCAWYMVGAEPVLERDEEEAYEWARRAAELGYVKAQYAVGYFTEMGIGCRRDILEANVWYVKAADAGDERAKQRIAAIRAAASGGNLPDGPAKISKKKQHGGVDKDDKECIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEW0</accession>
    <name>G0SEW0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CTHT_0059890</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS17976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696307.1">
        <property type="nucleotide sequence ID" value="XM_006696244.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0SEW0"/>
    <dbReference type="GeneID" id="18260027"/>
    <dbReference type="KEGG" id="cthr:CTHT_0059890"/>
    <dbReference type="eggNOG" id="KOG0384">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_29_1_1"/>
    <dbReference type="OMA" id="WVQIRDD"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="CD1_tandem"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CD2_tandem"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041150">
        <property type="entry name" value="Cdh1_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056302">
        <property type="entry name" value="CHD1-2/Hrp3_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025260">
        <property type="entry name" value="CHD1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF14">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18196">
        <property type="entry name" value="Cdh1_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13907">
        <property type="entry name" value="CHD1-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23588">
        <property type="entry name" value="HTH_CHD1_Hrp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01176">
        <property type="entry name" value="DUF4208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Chromo" evidence="13">
        <location>
            <begin position="288"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="13">
        <location>
            <begin position="388"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="486"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="804"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="14"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1355"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1583"/>
            <end position="1722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1379"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1410"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1583"/>
            <end position="1600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1607"/>
            <end position="1623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1631"/>
            <end position="1680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1701"/>
            <end position="1713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGS17976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1722" mass="197553" checksum="A0BAC26303E7CA4D" modified="2011-10-19" version="1">MNAVTDIVVLPQAQLQSRASLTMSTSPDPGSADGHNIPSPDDSTIHATPVIRVQNDASDAQSPQNDAPSPASADAVGSPDEGAEPEPAQEDEEMLSDSASNNDRADDGDFVAEPSPTSEHSNNSGAAPRPASTSSRPAAKRKATSIMDDEYIRENPELYGLRRSSRPTQRRKIVESEDDDESSESDAAPARKTTKKRRVERSQPASKRGTPARQPSIDDSDSDTYGGAKARSFQKKARRQELQGVQRWSSRRAAQVSAGTYQESDLEDEEDENMTPGYWAAEVEDNSPYIEKILRHRPKPGVEITPDVTRHDFEYFIKWQGKSHLHNTWETTESVAGFRGFRRLENYFKKVVEYELDLQFGGDEITPEQREQWMLDREREEEALEDYTKVERIVAVRDGDDGLQYFVKWKGLQYDECTWEDASLIQSQAQDKIDQFYDRSTRSWQSDRKQSNPETRTRMMKLEKQPDYIKGGELREFQMKGLNFLALNWTRGNNVILADEMGLGKTVQTVSFLSWLRNDRGQEGPFLVVAPLSVIPAWCDTFNNWAPDLNYVVYLGPESARSIIRQYELFIDGNPKKTKFNVLLTSYDYILADADHLKPIKWQVLAVDEAHRLKNRESQLYIKLNSFGIPCKVLITGTPIQNNLAELSALLDFLNPGKVLIDDELEALSSADNKGTGDAEQDEARRQRTQEKLRELHQAIAPYILRRTKETVESDLPPKTEKIIRVELSDIQLEYYKNILTRNYAALRDASGHKQSLLNIMMELKKISNHPYMFQGAEERVLNGSTRREDQIKGLITSSGKMMLLDQLLAKLKRDGHRVLIFSQMVKMLDILGDYLRIRGYQFQRLDGTIPAGPRRMAIQHFNAEDSEDFCFLLSTRAGGLGINLMTADTVIIYDSDWNPQADLQAMARAHRIGQKKPVNVYRLVSKQTIEEEVVTRARNKLFLEYLTIQAGVTDAEGKALREKFKEKGLKFDEAKTAEDISMILKMRSQNLFEQTGNQQKLEQLDIDAILENAEVTKTDIDDKINLSTGGIDWDNWMQVTDVKLDENALDWDQIIPADQLAAIKAEEEKKKHEEYLQKAMEEAAPRKAALKSAKKSAEIERQERIKKRWREREAEDLEEQRALLTDPRRPLGEKETRNLIRAFFRYGNFEEREEEIVHDARLTDRDRGYLKSIIDELIEVSKKAIEANNEKLREEEAKAGKPLAKKDKKAVLVDFGEVRKINAETVIERPPQLKLLRRVLREHEKEHGDALSFRLPEATKAASYTCEWGAREDAMLLVGIDKYGFGAWTQIRDDPQLGMKDKFFLEEHRVDKKEERRRTDDKTIQSPGAVHLVRRSEYLLSVLMAKYSNDENAKKAVENHHRSKKLLTNGIRRSEQNSVSASPAPSMSKKPSQRDRDHHRSYSNANDRGTPRPDKRKYNDDYDDRDSKQRRLDSDAKHDKKATSGKDQKEKPKLDPETMERLKRERARAVERFHELTKIPDDKIDPNDNVQVVWSILRPLQENIERIIYSKERVPIAKERAKFLGAEIRAFGNFLRGLKEKNGPNFEGLEQQFWEFLSDIWPLGDVKVSGKRLQKMYVSLAEADRQKEEEEKAKAKNPDLEDGEIPSDRDEPPRERDRDQPSRRPPPSRDPYRDDRREQRHEERRNDLDRRASDVGSSDAKRRAYYDDDRLSFYRRRPDLANNSRGSSNGGGGSGSSVPLRHHSSSSWHHSHSPPARRSPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEW4</accession>
    <name>G0SEW4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dl-glycerol-3-phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0059930</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS17980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696311.1">
        <property type="nucleotide sequence ID" value="XM_006696248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEW4"/>
    <dbReference type="STRING" id="759272.G0SEW4"/>
    <dbReference type="GeneID" id="18260031"/>
    <dbReference type="KEGG" id="cthr:CTHT_0059930"/>
    <dbReference type="eggNOG" id="KOG2914">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_13_4_1"/>
    <dbReference type="OMA" id="QVHTFDG"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050308">
        <property type="term" value="F:sugar-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07527">
        <property type="entry name" value="HAD_ScGPP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051806">
        <property type="entry name" value="HAD-like_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481">
        <property type="entry name" value="FRUCTOSE-1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481:SF4">
        <property type="entry name" value="GLYCEROL-1-PHOSPHATE PHOSPHOHYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01135">
        <property type="entry name" value="C1.5.6:_HAD__Beta-PGM__Phospha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS17980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="253" mass="27161" checksum="0DF01B94458B3B62" modified="2011-10-19" version="1">MGSTEHSFSAPAETVVFDGLLFDMDGTIIDSTDAVVKHWEAVGKEIGVDHKVILETSHGRRSIDMLKILAPEKANWEYVQYMEGLLPKLYGADAVEIPGARALLEDLVARNAPWAIVTSGTVPLVTGWLTALTLPYPTHLITAESVTNGKPDPACYLLGRERLSLSSPEKQVLVLEDSPAGIRAGKAAGCKVLAVVTSHTIEQVLAAEPDWVVRDLRSLKVEEVDGGKVKVVIEGALLKTCASDDGKSLKKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0SF17</accession>
    <name>G0SF17_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0060470</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beclin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696364.1">
        <property type="nucleotide sequence ID" value="XM_006696301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SF17"/>
    <dbReference type="STRING" id="759272.G0SF17"/>
    <dbReference type="GeneID" id="18260085"/>
    <dbReference type="KEGG" id="cthr:CTHT_0060470"/>
    <dbReference type="eggNOG" id="KOG2751">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024219_3_1_1"/>
    <dbReference type="OMA" id="EWDVYKA"/>
    <dbReference type="OrthoDB" id="20368at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043548">
        <property type="term" value="F:phosphatidylinositol 3-kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.40:FF:000005">
        <property type="entry name" value="Autophagy protein Apg6, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.40">
        <property type="entry name" value="Autophagy protein 6/Beclin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007243">
        <property type="entry name" value="Atg6/Beclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038274">
        <property type="entry name" value="Atg6/Beclin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041691">
        <property type="entry name" value="Atg6/beclin_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040455">
        <property type="entry name" value="Atg6_BARA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768">
        <property type="entry name" value="BECLIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768:SF4">
        <property type="entry name" value="BECLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04111">
        <property type="entry name" value="APG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17675">
        <property type="entry name" value="APG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Atg6/beclin coiled-coil" evidence="5">
        <location>
            <begin position="154"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Atg6 BARA" evidence="4">
        <location>
            <begin position="285"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="99"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="366"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="157"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS18033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="512" mass="57438" checksum="07CBB9A2791FB78F" modified="2011-10-19" version="1">MYCQKCRTPLKLDSSLEDLNPAAYDLLVATHNQQPTSKPVVSRTHVQDAARRAIYDRACRDATQPIFRRHSGAGRGDRDTSTMSFIFLTESQIAAATLSQQRNASQNAGPSSLPSQGGTDGTGDDEDAGKVHHEMERITKLWEILSARSDIDHPVCVECTDLLLEELQKKLEAATRERDAYIAFLKELQANSPTDEELRAREEALRKAQQAEAAAREEILKLEKEKDALDAELLALEEECRQLDMQEETFWRDRNAFASKLAEFQNERDSVNSKFDHDSRQLEKLQRSNVYNDTFCISHDGTFATINGLRLGRLSSHPVDWPEINAAWGHALLLLVTVAEKLNYRFEGYDPQPMGSTSRIIRYETPSPSSSRIILSPSSTTTNPTSGQTPKKQILPLHSTSDAPFLTSFIHRKFDAAMVAFLELVRQLGAHVYATTARDPTNYPAPRSLPYRIEGDKIGDVSIRLGGMAQDDVAWTKACKLTLTCYAYIVRILNRGINPCCEEPNDLIYFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0SF24</accession>
    <name>G0SF24_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative high mobility group protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0060550</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696371.1">
        <property type="nucleotide sequence ID" value="XM_006696308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SF24"/>
    <dbReference type="STRING" id="759272.G0SF24"/>
    <dbReference type="GeneID" id="18260093"/>
    <dbReference type="KEGG" id="cthr:CTHT_0060550"/>
    <dbReference type="eggNOG" id="ENOG502SCCJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042807_0_1_1"/>
    <dbReference type="OMA" id="KRQHDPN"/>
    <dbReference type="OrthoDB" id="5550281at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="137"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="137"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="277"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="294"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS18040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="362" mass="40258" checksum="96210637348E0DF0" modified="2011-10-19" version="1">MPRPPKNKQPAVEPQPAPVPVAPAVHHQIPQQPMAVAPQALNLKQTPVIDVAQFIRVRDSVYQRLQTIQDLIRSFSQDYLRQTNLLIGEGTTIENGNELDRIASSITNLMPAVVPQPQPVVEEKKERKKRQHDPNAPKRPLTPYFLYMQTARPIIAADLGENCPKGAVQDEGQRRWSVMSPQEKLGWNQAYQYNLRLYNARVHAYKHGNMNAKNMTDEEARIYADQHNIPMPPLAHAEELNQQQNDQEAIAEQLKQTQNHAQAAAQAAPVQEQPASVEEEAPSAEEEQAPASKTPKKKETRNKRKSMATPAAPTPAAEPATDAKSAAATPASPETKKRKRVSKAAEQVEEPKKSSRKKSKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0SF97</accession>
    <name>G0SF97_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0061280</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696444.1">
        <property type="nucleotide sequence ID" value="XM_006696381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SF97"/>
    <dbReference type="STRING" id="759272.G0SF97"/>
    <dbReference type="GeneID" id="18260166"/>
    <dbReference type="KEGG" id="cthr:CTHT_0061280"/>
    <dbReference type="eggNOG" id="ENOG502RZ9Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_446177_0_0_1"/>
    <dbReference type="OrthoDB" id="21470at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12323:SF0">
        <property type="entry name" value="CALCIUM HOMEOSTASIS ENDOPLASMIC RETICULUM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12323">
        <property type="entry name" value="SR-RELATED CTD ASSOCIATED FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="1">
        <location>
            <begin position="25"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="612" mass="67569" checksum="6046763D4DD675A6" modified="2011-10-19" version="1">MALAELIVAKTALSGALFRPDPRPCSRDDIDSMHILLADTIAECSPRNVQRCKQWALANLVPSSARIAPFCKYLIALSKSFGGEKDSALAELKDKKRLPSVRRRRLHILYILNDILYHVKHRNNDDAFAQKLEPTLPALFRSAAAFTNCPKHFKKLNDLVCLWEEKGYFPPSTVQQLRTAIEEGPTSKEDNKNSVEADNSAAVLAKAAKSTPWVMPAMHGDPSTPWYDLPAGNWLPILEPNSTRPMNPAMIKPLVLSQGPADKKLVEAVKKLLDDVDRIYGCKEVNLDEPRPNIGPLGEPVEIDEVTGEIIGGETYYGWSRPFCEKMKRRLRGQSGSNSDDDVRGRAQTVPIGGGALADMDNGTVDIVLDRLHDHFHDDDPDLIPGLEADPIDNVAGAGAVAVAIATITVADIGRAAPIIPVPAQEINLHPHNTGLVQATHRAMATILLPRAVPLQHIQLAPGLNPQLDHNNNTDLLIPLHRHKCPSQCRLSRRRKQILLPGASPFHRRTLPIIRVHGLLCRRSRSLKDLQASILRTTSRPLKGATMLGILCRRFLHSWHRVGRPRPHPLRRARISRAFLILRLVLGVQGGVMGEVGGVIVCQYPEEFSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFC7</accession>
    <name>G0SFC7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative F-box protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0061580</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696474.1">
        <property type="nucleotide sequence ID" value="XM_006696411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFC7"/>
    <dbReference type="STRING" id="759272.G0SFC7"/>
    <dbReference type="GeneID" id="18260196"/>
    <dbReference type="KEGG" id="cthr:CTHT_0061580"/>
    <dbReference type="eggNOG" id="KOG3745">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003875_0_0_1"/>
    <dbReference type="OMA" id="WYQVKRD"/>
    <dbReference type="OrthoDB" id="5554140at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009976">
        <property type="entry name" value="Sec10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048627">
        <property type="entry name" value="Sec10_HB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100:SF1">
        <property type="entry name" value="RECYCLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100">
        <property type="entry name" value="SEC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07393">
        <property type="entry name" value="Sec10_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="39"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="779"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="555"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="779"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="789"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS18143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="978" mass="108878" checksum="78EA62352443E08B" modified="2011-10-19" version="1">MSGRPSSRREAAAGSSKVKTNSILQTLQAATIIDTKPVLPAEILAMILDYLPVSDQMRFARTSRRMCEMVYEDARWVARLKAMGCWNEAEARRRFEEAMLARRKREEEAKAIAQEAAQAARPGSAGASAGRMSRGGVTVAGSNGPTANNRGSLLFDATVEEERTKKLQEQRQQQQKLVMMMAEVRDGFETMKVGGPGAGTGPDPMRDPDALLQVIKNARSIRGYARQEYGKIYGALAPFYFDLCRAKSHTDPLVFKVFRDPERQAQMLANLRTFARSDWSAGCLKREEKVETMMAIFESAALREFEQGYEFWEVDGRMRRYANVLNMLNGSNAAVDLFIHKHPIFSDKELLANPTDCIRHALGDNISLEPSRLFFETLSRKVNEQAGVIQRIFPNPAQVFWAFVDKVREDIIMEYATPLFDETRERSIPSYLRAVSGLFEQMMHFLRTLTPPKGGDEENVAQEEHIKEMALKVFEPHMDLYLQDELDDFTKKAEHEVGEWERKLSEQEASAESFYMGSFTANRQADKKDFLTTFKKVVMMPVTVLPTTLTLPFKSGGSSGGASTNGISTQQPSRSQSPVPPAAVAGTGSAPTDELAAKAALMTARLEGIKSLFSIEVALNLIHMAKASLGRMAVFIQLGGQAGGEAREQCAAVFVALLRILGNRHIKPGFDRAVAHLSQYNPREVREHDRGVAPLVTFIELVNVGDLISQMIDVFYEQQLAQPKIADRNDFLDPAGLAKKKFEQMLDESVAAGLNKGIDVLMDEVEYICATTQLPTDYNPGLSTTTPDSSGITGTVSSPTVSSPVNEKRFSTSTLSSTFGLNLDIGPTPTAIRIRDLVASHTSMLVGSTDKSMLDVFNGEVGLRLFNALCKHLKRQRISTEGAVKLIADMNLYFDFVRTQLKNNDLLVYFKALRELSQIYLIDAKHAKEMAAIIADGDRFGGVFRAEEVYEYAERRADWYQVRKDVERAMYGLECSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFG6</accession>
    <name>G0SFG6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0070740</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697349.1">
        <property type="nucleotide sequence ID" value="XM_006697286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFG6"/>
    <dbReference type="GeneID" id="18261112"/>
    <dbReference type="KEGG" id="cthr:CTHT_0070740"/>
    <dbReference type="eggNOG" id="ENOG502R139">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_585261_0_0_1"/>
    <dbReference type="OMA" id="VITRICW"/>
    <dbReference type="OrthoDB" id="2588098at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="85"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="467" mass="53734" checksum="7FB3751A20075492" modified="2011-10-19" version="1">MTTKPTVRNTGENFYLVAPRVKRMASLTRDDEVGKLPEILFNRTPNLLIRLLTIPEIPPVYIPGSTLEDQHPTASSSNTPSKTNLSHLPTELHLLIVSLLTPSIEDILSLALTCRYFWTICWAPIHTHFANRALGLWARDQPIICAGEFVEVEDFPPECFTKQEIDSLRARKIIIHPSHRRVRFPKFMMFHFKEEEDFQKEKVVDLRRESLFAIASVARRGRKERDGEHHDKDPAFRLAQKYLVVDDKTYFAPGEKWMLRNWTTKEFVRAEALAIEQQVDLDRAESESELELGFQHTATPSDTDSDTQVETESETEPDEPNSGTDTDLGSCTQAETESSEPVRVTETDKDTDTPTEIETKAESGTARIDRLDTYPWSLGHAVLSRICWTTWPGGGLPTKRLPLHLRRGVWAGHRFDITTWRRHVSEAQRKNTFKDEDEKGEEVEWKDVSDEVRKEMDEFLEMLYGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFM3</accession>
    <name>G0SFM3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hmp-phosphate kinase (HMP-P kinase)-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0071360</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RICTOR family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697406.1">
        <property type="nucleotide sequence ID" value="XM_006697343.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0SFM3"/>
    <dbReference type="GeneID" id="18261174"/>
    <dbReference type="KEGG" id="cthr:CTHT_0071360"/>
    <dbReference type="eggNOG" id="KOG2598">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3694">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001013_1_0_1"/>
    <dbReference type="OMA" id="TAQDPMF"/>
    <dbReference type="OrthoDB" id="271111at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19367">
        <property type="entry name" value="TenA_C_ScTHI20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.160">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011072">
        <property type="entry name" value="HR1_rho-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036274">
        <property type="entry name" value="HR1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028268">
        <property type="entry name" value="Pianissimo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028267">
        <property type="entry name" value="Pianissimo_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029453">
        <property type="entry name" value="Rictor_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029451">
        <property type="entry name" value="RICTOR_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029452">
        <property type="entry name" value="RICTOR_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13298">
        <property type="entry name" value="CYTOSOLIC REGULATOR PIANISSIMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13298:SF11">
        <property type="entry name" value="RAPAMYCIN-INSENSITIVE COMPANION OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02185">
        <property type="entry name" value="HR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14663">
        <property type="entry name" value="RasGEF_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14666">
        <property type="entry name" value="RICTOR_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14664">
        <property type="entry name" value="RICTOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14668">
        <property type="entry name" value="RICTOR_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00742">
        <property type="entry name" value="Hr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01303">
        <property type="entry name" value="RasGEF_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01307">
        <property type="entry name" value="RICTOR_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01308">
        <property type="entry name" value="RICTOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01310">
        <property type="entry name" value="RICTOR_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46585">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51860">
        <property type="entry name" value="REM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="REM-1" evidence="4">
        <location>
            <begin position="93"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="137"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1210"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1370"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="176"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="199"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1226"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1439"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1458"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1476"/>
            <end position="1485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS17788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1857" mass="205683" checksum="DD123EC5C517096A" modified="2011-10-19" version="1">MLSASANPSQKQQAQTTSTSSQQPQPPSGRPSLDRGDGLQPPAPNAGGRNLSASAVSFVSRGPSLNPSPAAPGSFSSDLRSLNVSRAGVRPPDMFPPDKFGDDDSLTAHERTIAYLREALSRELKIKEGSENMLEALNSKKAKQTKEQRQRVEAELASSNQRIKELRQRLTEAQRSRAAPTTPTRSRTDGGLFPGSGGFRSPPSASRSGAGSDADEPFESPTYALTELLQALEVGGMTSDYYVSRANSLVDLFKRHPALKYDLVWPIFGRRMQSLLLSESREVVAAAYRMMRYAITDINSLRVMRSLNTDYLVTWSLIKDRKADVEREQALKFVRAFLDVKDGVREISRAVVRAIAAVAEEPDERLRPICLETLAEILVHDPQLVIASGGLAPLKDALADGSYKALESLTAAFLYLLDSPHRRKFLRPGNELEVLFTAFTDELVSNERFLKQSAKCIASALKTWPGLMTLSMYNFRAIKSMISSMVAQTGPIRETILDLIFSLLRIKPPAWANSFLAGRRLTTYGRVANLRATTVTKPSSNANDLDDEEGGDEQNFVEHYTALLLAVFIKCGLVPALLKLTQDNDNQPLRRKSTLLIGEVLRLASRLLPPSWNSELHLLPELFIAAAKLRDEAHFIATGVIYQISSVNKTLYRTTPLSSLPSSHHALDIGSLDDHPKSNVAVNTDEGTFRQLIIESNVLNSSNYNKWNWEVIQRIIEGPLTNGKRLEEAIKASKFMKRIMSFYRPFKYKFSEVKSSRNSQKYVRAGCSLMHALLQSNEGVKYLSDNKLLRQIAECIAQCDPTSGLTAQDPMFSKDRLADTLCGGYFPMLGVLSGDVKGMQMLDRWRIFNMLYRILDLKQRPDLIKLMLSNFDYSLQGHPRVLLSKALTAGTKEIRIYATNVLRKYATRPAVSIPGQEPNDSKWAIQLLVTQLYDPEIEVCATAVKILEKACNTKNNLEYIVECRPALDHLGEIGAPLLLRFLSTSIGYHYLDGLDYISNEMDDWFLGRNDTYVSVVEASLARAFLEPPQQEDHANRLSVFEDDQEMEVDAHVPPHFYRELTRTEEGCKLLSEKGHFDEFAATIREYGMQSEDPELIVKVKGCLWAVGNVGSMELGAPFLESCDVVEQIIKIAQSHPVMSLRGTAFFVLGLISRSIHGLEILAENGWDSNTNILGHSLGLCIPTDLSQFFSLEPWQHIPVTAIDLPDSQKTEKGDLWISPPPLPGHSRPSISSRSRSQSLLQSVQEEDPNMDNETITSDGFPPHAVFDPDPTNQRILELIVDMSNLVLYRRARAELLQIKAQQSSQSKKGMRSCVGGAGGNAPNSFSQPGLFRKVLMLLECRYYRLADRNMIVGLFDKSVLRTVVYEEDRTGAGGAGRGSMLSSNEEESEMDEVSRNGGDQEAGATRPKAPVDAPGGAKNEGNEAGSDDDDEQSNVNDNDQDRETREQKEDEQNGEQNEHEDDEDEDGQGVDGSGDNEQRAERQRSVSDPSAAFKRRAAHGCYAMTATTALTAQNTKGVYAIYQVPPEFLRKQIDAVIEDVGVDVVKTGMLASAASIETITQAIEYHKVSTIVVDPVMIATTGACLLPIEALNALRTRLLPHATIVTPNVPEALKLLSGLPSSSATDEPTIPQAVQSVADLEILARIIARRLGPQWVLVKGGHCPFRKDGTVAKEEEERELVVDVLVGRKQRNEDDGELIQFARANSLSAYKARVTQDIATSASIVTHIFNEMELHIKYCKDFGISREEMESAEENKACTAYTRYVLDIGQSQDWLALQVAMAPCMLGYAAIAKQLYADSRSKREGNIYWSWVENYIGEDYSAAVKAGSDGDWLLGDVQLELSRYGVADSKRAEREQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFX6</accession>
    <name>G0SFX6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SANT SWI3, ADA2, N-coR and TFIIIB'' DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0072500</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697509.1">
        <property type="nucleotide sequence ID" value="XM_006697446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFX6"/>
    <dbReference type="GeneID" id="18261288"/>
    <dbReference type="KEGG" id="cthr:CTHT_0072500"/>
    <dbReference type="eggNOG" id="ENOG502S338">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036108_0_0_1"/>
    <dbReference type="OMA" id="HAQAWRQ"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="358"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="358"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS17891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="452" mass="50211" checksum="5408241841CDBE26" modified="2011-10-19" version="1">MHQWTISPVPEYLYSNSATNHSNEIQQRTANDVQSWRPPQTASMSSLQRQPLQQVFQQQAQQQQQQQQEQSSHASLFANHTAWYSQSPYAAPAQQPDMTRRDQPAVDYRYQQPQQAAQPHPQQPAQQQQQQQPAQQQQQQGQPQQQAHPQHHAVPQVQQTMARAQQQQSAPTQQPAPAPAPATTGRRKRPAPGSHPPAHPAQHAPQHPPPHAQHPQAAHVAQHGAPHPGQHVAHHAQQHPGQHPAQHMQGPAPGQHQQQAPQQPQQPGQQAPTVSPQIAQSGVPQKGQPQVQPQPQQQQQVQQNQHIQHQFQPAPQAVQQPAAQQQPVGAPAGTQPATAQAQPAQEKPDPATAPPPPKKTRTNTPWTPAEELKLKQMRDAGQSWAEIAKSFPTRTEGSVKKHWYKDMHYAEFAEDERTALLNAIKEYENNKWKVIGQKIGKPAKACEQTVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFZ7</accession>
    <name>G0SFZ7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ribosome assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0072720</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697530.1">
        <property type="nucleotide sequence ID" value="XM_006697467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFZ7"/>
    <dbReference type="STRING" id="759272.G0SFZ7"/>
    <dbReference type="GeneID" id="18261310"/>
    <dbReference type="KEGG" id="cthr:CTHT_0072720"/>
    <dbReference type="eggNOG" id="KOG0302">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025272_1_1_1"/>
    <dbReference type="OMA" id="RHWKPNA"/>
    <dbReference type="OrthoDB" id="2161379at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051972">
        <property type="entry name" value="Glutamate-rich_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903:SF1">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="5">
        <location>
            <begin position="90"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="303"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="408"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="156"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS17912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="501" mass="54627" checksum="C9272DF792DAB854" modified="2011-10-19" version="1">MPKRQAEDEKAAGPLKGGERPDAMDVDDKDNDMGEFEDEFEDEFSEEEIIEAGVDGRPDTEREAEEMEVDSAAPETFIVGRTKLEPGQTLVPDASTYRMLHHLSTPWPCLSFDIIRDGLGDNRSVYPVTMYTVAGTQADSARANDNSIMVMKFSGLSKMQGGGDDSDSDTESSDDDDEDDDPILEHKSIPLTSTTNRIRAHQTPSQDSSKPPITLVATMTESSNVLIHDITPHLTSFDTPGTVITPQQNKPVCTIRAHKVEGYGIDWSPLHPAGKLLTGDCEGIIYMTTRTDGGGFVTDTRPFVGHQGSVEEIQWSPSEASVFASASTDGTVRVWDIRSKARKPAITMKISDVDVNVMSWSRLTTHLLASGDDAGVWSVWDLRQWKPGAAGAAGAASSVGKPTPIASFNFHKEQITSVEWHPTDDSIVAVSAGDNTVTLWDLSVELDDEESKDTGGVQDVPPQLLFVHYQNLAKEVHWHPQIPGVLVATGEEFSVFRTISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>G0SG13</accession>
    <name>G0SG13_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0064660</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696770.1">
        <property type="nucleotide sequence ID" value="XM_006696707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SG13"/>
    <dbReference type="STRING" id="759272.G0SG13"/>
    <dbReference type="GeneID" id="18260504"/>
    <dbReference type="KEGG" id="cthr:CTHT_0064660"/>
    <dbReference type="HOGENOM" id="CLU_1111269_0_0_1"/>
    <dbReference type="OMA" id="RELNCRI"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS17152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="250" mass="27977" checksum="721E8E217E35997C" modified="2011-10-19" version="1">MAPSSAVVLAALKRAREEKLKELNTVISVTEKLLRVVEDVERKLEQKATPAGIITLLVERLNFPRRDIVKVYPVNSGFAIEVSHPELREPFAAKARELNCRIDLEMPTYAYLVKNVPEYILAHDGSRRHTYPLIADEVEAVTKKKLSIHAVRDTPRAYLVVLTKKVTPFMIFDSDPFILLKRKVRIHTCGSYFGFHHKDKRRSSARCGECGGPLHNHTQHLALPQCPNCLSPPDPGTKTAPISRGSGKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGB2</accession>
    <name>G0SGB2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0065700</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696869.1">
        <property type="nucleotide sequence ID" value="XM_006696806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGB2"/>
    <dbReference type="GeneID" id="18260608"/>
    <dbReference type="KEGG" id="cthr:CTHT_0065700"/>
    <dbReference type="eggNOG" id="ENOG502SMA1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062358_0_0_1"/>
    <dbReference type="OMA" id="FIDYQDC"/>
    <dbReference type="OrthoDB" id="71437at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046312">
        <property type="entry name" value="DUF6454"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20055">
        <property type="entry name" value="DUF6454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS17251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="369" mass="40265" checksum="E7C16A30BACE5245" modified="2011-10-19" version="1">MADLIRDVLSYIPASSRQKVVDASSKMMNAVAAINAVNATALLTLFSTISPAIRSVNVTIHQPGVAIAPSPLPAPNPSSHSEEIIRQFVQLDRTTKWALVEKIAFEGDTYEPEGIVRLGDGERYFVASFQRIYPLPGDNSPNPHYEGFAHLLIFDSQGSRVASATLTESGAAEHHAGGIDYDGTHIWATLGQNKPGPNSTATLVRIDPETLHVEPMLRAADHLGAAVHDVETGNVLTLNWGARKAYVWNLRYKAAPQPAFTQPRALVANPSHWVDYQDCKFLGHSQRFGFRPVMICSGITKLYGAVIGGVSLVDMESMVPLYEVPLTMRSDQGALVTKNPMDVAIVDGKLRLFFLPDERNSTLYTFEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGL7</accession>
    <name>G0SGL7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Transketolase</fullName>
            <ecNumber evidence="4 15">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CTHT_0066780</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 15">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10508"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <text evidence="15">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="12">Binds 1 thiamine pyrophosphate per subunit. During the reaction, the substrate forms a covalent intermediate with the cofactor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 15">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="4 15"/>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696974.1">
        <property type="nucleotide sequence ID" value="XM_006696911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGL7"/>
    <dbReference type="STRING" id="759272.G0SGL7"/>
    <dbReference type="GeneID" id="18260716"/>
    <dbReference type="KEGG" id="cthr:CTHT_0066780"/>
    <dbReference type="eggNOG" id="KOG0523">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_0_0_1"/>
    <dbReference type="OMA" id="ADYMRGS"/>
    <dbReference type="OrthoDB" id="10267175at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000004">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055152">
        <property type="entry name" value="Transketolase-like_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049557">
        <property type="entry name" value="Transketolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="TRANSKETOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522:SF2">
        <property type="entry name" value="TRANSKETOLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22613">
        <property type="entry name" value="Transketolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 13 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12 15" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="16">
        <location>
            <begin position="356"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="117"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="527"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="14">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="14">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGS17356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="686" mass="74958" checksum="546A034291090668" modified="2011-10-19" version="1">MPYTDVDQLAINTIRVLAADATFHANSGHPGAPMGMAPVAHVLFNRIMRFNPKNPNWVNRDRFVLSNGHGCMLQYALLHLYGYAVSIDDIKAFRQVGSITPGHPESHDTPGVEVTTGPLGQGISNAVGLAIAQAHTAAVFNKPGYDLINNYTYCFLGDGCLMEGVSAEACSLAGHLQLGNLIAIWDDNHITIDGDTNQAFTEDVLKRYESYGWHVLTVEDGDHDLEGIEAAIRKAQEVKDKPTLIQLKTTIGYGSKQQGSHGVHGSPLKADDLKQLKEKFGFNPEESFVVPQEVYDLCGKAAAAGAAAEEEWNQLFAKYGEEYKAEHDDLLRRLRGDLPEGWEKNLPTYTPNDPAVASRKLSEIVLNKIFDAVPELMGGSADLTGSNLTRWKGAVDFQPPSTGLGNYAGRYIRFGVREHGMGAILNGMAAYGTILPYGGTFLNFVSYAAGAVRLSALSQVRVIWVATHDSIGLGEDGPTHQPIEVLTHFRALPNCMVWRPADGNETSAAYYVALTSKHTPSIIALSRQNLPQLEGSAIDKAIKGGYVILEQEKADITLVSTGSEVAICIDAAKLLAEQHNIKARVVSLPCFEVFDTQDKEYRLSVLPDGIPSLSVEVMSTMGWERYSHEQFGLNRFGVADCTNLLAQQKFEFTPEGVAKRALATIDFWKDVPNIRSPINRAFQQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGT7</accession>
    <name>G0SGT7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0067520</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697044.1">
        <property type="nucleotide sequence ID" value="XM_006696981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGT7"/>
    <dbReference type="STRING" id="759272.G0SGT7"/>
    <dbReference type="GeneID" id="18260790"/>
    <dbReference type="KEGG" id="cthr:CTHT_0067520"/>
    <dbReference type="eggNOG" id="KOG0926">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001832_0_4_1"/>
    <dbReference type="OMA" id="FCYLDDK"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17982">
        <property type="entry name" value="DEXHc_DHX37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000637">
        <property type="entry name" value="ATP-dependent RNA helicase DHX37/DHR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="427"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="626"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="146"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="698"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="294"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="704"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS17426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1255" mass="139666" checksum="99ECA1DB70DEFCB6" modified="2011-10-19" version="1">MTGRKSFAPNRVRKRKVLDRMRAAENGTRDAPQDTNVLEITPAEQAERERKKAQLREELRPAGVKVSSKKAKRLEKYIENKLKKDENRELLAKLAANKIDTSLFVSAKNLGQTKETKRDALRRALKEQNAGLTLEKSDAELLYQRRTVADVEPRENGVASLSEDEEMEDSATLQKGARLAGPRPQQEQAKEEQPESEESEQQEEDQSEQAQPEQPKPVIQIAPGSGLKRPLELDESGRPKLAKRQKRGGVKSKFKVEAPVVLMEPSSEEWSGFSDDPDAASGAGSAEGSSQEESASESESSESDNSEESSDENEDIESSEAEAEDAESEDSAEAARRRQERSSAFKAWAQQARNEALGYKPVETGPLQIPKPANFVPRPLEEDPLPIELQPTTNVDRKAYAVPVNRSPEIQAARYQLPVCAEEHTIMEAIHNNDVVVICGATGSGKTTQIPQFLFEAGYGAPDGPTPGMIGVTQPRRVAAVSMSKRVAQEMGDRSDTVAYQIRFEGTVDPKTVIKFMTDGVLLREITQDLTLKNYSAIVIDEAHERSVNTDILIAILSRVVKLRADLAKENPAIKPLKLIIMSATLRVEEFTHNTTLFRVPPRVIEVEGRQHEVTIHFSRRTRHDYVEEAFRKICRGHRKLPPGGMLVFLTGQNEIMQLAKKLKAEFGGMTSAAGPKVRISASEAPVEVEDIDFGEADDRNVNDVDDYDDVEFPSDDEEEEKEFELEDEEVGTGPRKMHILPLYSLLPTKEQMKVFEPPPEGHRLVVLATNVAETSLTIPGIRYVFDCGRSKERRYNPVTGVQSFEIGWISKASAQQRAGRAGRTGPGHCWRLYSSAVYERDFPQFADPELLRMPIEGVVLQLKAMNLQRVVNFPFPTPPPRESIAKAEKLLTYLSAITPEGKVTPLGQTMSIFPLAPRYAKILLLGHQHDCLPYTIALVAGLSAGEIFIPESQAIPAIVEQNEEFRTNEDVIAEDKRARIQKAYNTVHKNFCYLDDKSDAIKLLQVVGEFAHEPTEEWCQSHFVRYKALKEVRQLQSQIAQLVRTNLPAFANFQLPDKMGPPTPKQVQALKQFVAAGFIDQVAIRADKAPNPPPMPRKPHRAIDVPYIPLIPLEDTGERSTDPEQALLEKLVYIHPSSPLAHLSVSECPEYIVYSHLQRGSNTGADGEKKAKIRMHALTDLTGSQLAALARGTPLISYGKPIKEVKGSESEDGKTREVWVIPYLRAETGGGLGWPLPARKVTQRRIPGKGWVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0SH14</accession>
    <name>G0SH14_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3 6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0068320</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3 6"/>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697121.1">
        <property type="nucleotide sequence ID" value="XM_006697058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SH14"/>
    <dbReference type="STRING" id="759272.G0SH14"/>
    <dbReference type="GeneID" id="18260870"/>
    <dbReference type="KEGG" id="cthr:CTHT_0068320"/>
    <dbReference type="eggNOG" id="KOG0549">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013615_12_0_1"/>
    <dbReference type="OMA" id="VHMHYTG"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044609">
        <property type="entry name" value="FKBP2/11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779:SF7">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="26"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS17503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="120" mass="12780" checksum="9A8446AE2FB11E56" modified="2011-10-19" version="1">MTIPQLEGLQIEVKAEGKGTRETQRGDNIDVHYKGTLTDGTKFDSSYDRGTPLNFTVGAGQVIKGWDEGLLGMKIGEKRKLTIAPHLAYGSRGVGGVIPPNATLIFETELVGIKGVAPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0SH69</accession>
    <name>G0SH69_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="16">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CTHT_0068920</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="16"/>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697176.1">
        <property type="nucleotide sequence ID" value="XM_006697113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SH69"/>
    <dbReference type="SMR" id="G0SH69"/>
    <dbReference type="STRING" id="759272.G0SH69"/>
    <dbReference type="GeneID" id="18260930"/>
    <dbReference type="KEGG" id="cthr:CTHT_0068920"/>
    <dbReference type="eggNOG" id="ENOG502SJGH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031730_0_3_1"/>
    <dbReference type="OMA" id="TAIWRYM"/>
    <dbReference type="OrthoDB" id="5558646at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF18">
        <property type="entry name" value="ENDOGLUCANASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012045236" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="17">
        <location>
            <begin position="16"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="18">
        <location>
            <begin position="16"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGS17558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="237" mass="25134" checksum="26ED998BEB7F1AF3" modified="2011-10-19" version="1">MKLLAPLALVGAASAHTIFVSLEVNGVNHGVGNGVRVPSYNGPIEDVTSNSIACNGPPNPTTPTDKVITVQAGSEVTAIWRYMLNSQGSAPNDVMDSSHKGPTMAYLKKVNNATTDSGVGDGWFKIQEDGFDGTTWGTERVINGQGRHKIKIPECIEPGQYLLRAEMLALHGASNYPGAQFYMECAQLNIVGGTGTKKPSTVSFPGAYSGNDPGVKINIWWPPVTSYKVPGPPVFTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHR2</accession>
    <name>G0SHR2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycoside hydrolase 131 catalytic N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0073070</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS16982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697564.1">
        <property type="nucleotide sequence ID" value="XM_006697501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHR2"/>
    <dbReference type="STRING" id="759272.G0SHR2"/>
    <dbReference type="GeneID" id="18261345"/>
    <dbReference type="KEGG" id="cthr:CTHT_0073070"/>
    <dbReference type="eggNOG" id="ENOG502SHCH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063723_0_0_1"/>
    <dbReference type="OMA" id="THEYLNV"/>
    <dbReference type="OrthoDB" id="5283326at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041524">
        <property type="entry name" value="GH131_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34612">
        <property type="entry name" value="GH131_N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34612:SF4">
        <property type="entry name" value="GLYCOSIDE HYDROLASE 131 CATALYTIC N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18271">
        <property type="entry name" value="GH131_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409207" description="Glycoside hydrolase 131 catalytic N-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase 131 catalytic N-terminal" evidence="2">
        <location>
            <begin position="41"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS16982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="297" mass="32821" checksum="BD9F4773D8555F43" modified="2011-10-19" version="1">MHRSLLLTLLTTAIAVLARPPSRHPHSPSAAAAPGTIKCPIIFDGRIKTTTQLTDFDSYSTSPFNPDYVKGQTLKWSDIIKFPSVSPSRFDDPDQHKPIEVTISDASIFMNQRGFRRAGLQFQGDSNTGSAGSKGVKTIHFSVRWDNARPLNLSHEYLNVWHETADYSANQFNFEGGAILGQTQLPADTWKVLDRNNRQIWAVKIEREGWQNFAITVDYEKNTLQVYYSKDDEPLTAVTSAVYNNNAGEGQFQIGILKKPTGTSDVVNSGYQSPNLDEGLLYGGLFVEDSAGGCVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHY2</accession>
    <name>G0SHY2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0073790</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697634.1">
        <property type="nucleotide sequence ID" value="XM_006697571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHY2"/>
    <dbReference type="STRING" id="759272.G0SHY2"/>
    <dbReference type="GeneID" id="18261417"/>
    <dbReference type="KEGG" id="cthr:CTHT_0073790"/>
    <dbReference type="eggNOG" id="ENOG502RU3A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002712_0_0_1"/>
    <dbReference type="OMA" id="YRYHFSQ"/>
    <dbReference type="OrthoDB" id="5402622at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038769">
        <property type="entry name" value="MTC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38426">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38426:SF1">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1082"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="589"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="700"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="879"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="399"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="645"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="708"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="735"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="746"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="800"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="883"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="913"/>
            <end position="927"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1105" mass="119575" checksum="725E1E93F861DDA7" modified="2011-10-19" version="1">MTDHRNASFSTSSPVAAGQSSRGSTPVSSTGAEAPTRHGDKRGSLTGRTHKHRSSSGFLLADSLLNRHRRSRHRSSEPDSQHHLHRHHHYQQQQQQQQELSQSQDVNAQPETPTRPSWSSTASPQTPSSTTETQRTSFATESTAVSSPSPSRSTVSQLDLESAQIVNMALTLSESRRLAASRRTVSQPVSSGAAPPRLSPLPDAGAPGSSLRYHLQQQRRAVGQPRTGSPKPDRSPKMVPTGTNTLTPMHSSFEHTTPQPYRYHFSQSTLARAQKAREYLELMAQYRRLLELVPPLEPPREKTAKSRNASPPGTPRDSAPASRVSSSELETKLGRPYNPLQYIRNRKVRARERKAIDGEAQGFNDVKKVSDWIDEVAKWVATGQHRIPGNPALPPFPGAQHAALQASSSSSPALSSVRNPAAARPKRPRVDWVIEPADMLADVYWLEQDDNKKLVEDRQWRRVFPQRSDLGKQLAHDDRLAATPGSARDSSDAHTPGDKSTPDLPTSSHEHVLTAARDRAQQKLRALKASHHRQASVITNRDLLRLHRSSMSESSDTDGTDRRRWRVRPPGGKSVLELKVEEMYAKELRDAESHPLYDPETKQLKQSEPMTPEQGGPTASSIRAHRRASSRMDYSDSRTSASVIGLGLKPLPLPHGGSSPQPGARASLEVPSRVGRFSMEEESSQPTTPELRPAREIGLIPPIGMDLSPLSPSRPSSPPRVSGSSSNPLTKVRSIFHDRSKERHAASATASASASASASASAAAAAAAAAVETQTQERLQVGAGEDGLNPAVLSDAATASPETGPSNVPSPQRGLSRSPGERATASGGAEGAKLGHRPSKSVSSGKLRGEDGSLSFRSLFRGPRIDSVLKSGVSKVSDLFWRGGRDGVEDRLSGSSDEGEGDEDATARVRKAKKEEKTPPRDKEKGLEASPHSIPGLTVSSAEQGNQQQTIMLQHPPAQPLSRRSSRFEMLKPPRIDIQSASASSSSPIPQLVVPESVASDAESTTAAQDRARLAGSRLDAVVTGLAPTTSRPSHHAWPVPGGGMAPVPILSRRDVARVRAMLLSTGIHARELSRRAHTSPLLPPADIIPFFFFFFSFLLRTNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>G0RY25</accession>
    <name>G0RY25_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CTHT_0005150</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691053.1">
        <property type="nucleotide sequence ID" value="XM_006690990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RY25"/>
    <dbReference type="STRING" id="759272.G0RY25"/>
    <dbReference type="GeneID" id="18254553"/>
    <dbReference type="KEGG" id="cthr:CTHT_0005150"/>
    <dbReference type="eggNOG" id="KOG0036">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_2_2_1"/>
    <dbReference type="OMA" id="VISYAEW"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000016">
        <property type="entry name" value="Solute carrier family 25 member 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="25"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="63"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="130"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="325"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="444"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="551"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGS23811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="644" mass="70221" checksum="F018A3FDAD29E0D2" modified="2011-10-19" version="1">MSVISDVVSEQQSPVAVAMEESQHERDKRIEELWRKLDPAGHGELDFKGLQRGLRRIDHPLQNADEMLKDIISHLDTSGDGKIQYEEFRAFVEAAERQLFLLFQSIDSNHDGRLNRHELEAAFYRAGLSVPKRHLTGFFNEIDMNRDGYITFDEWRDFLLFMPPNHNGSPLEAALSFYSSIVTVNQEGDSLVSDDTLEGHLGTAGFLLQALFGTLLRLASPDLGLPPVRSPDITRPSTLHPSSPSLPYSEQIHSLPPEMTSNPAAMRYGPTGGISSQVLADAGLQRSVLQYEGVAQASTPTFTELLEAEADPSAGRVTTRLTDLLPEPGYFLAGAVSGGVSRTATAPLDRLKVYLLVNTKTRSNVSVLSAIKSGHPMTALKHAGGPVIDAIASLWKTGGFRTFFAGNGLNVVKIMPESAIRFGSYEASKRFLAAYEGHNDPTQISTVSKFVAGGIGGMTAQFCVYPIDTLKFRLQCETVQGGLKGNALLIQTAKNMWADGGVRAAYRGLGLGLLGMFPYSAIDIGTFELLKKTYVRLSARYYDIREDETQLGNVTTAVLGATSGALGATIVYPLNVLRTRLQTQGTAMHPPTYTGIIDVATKTMRNEGVRGFYKGLTPNLLKVAPALSITWVCYENMKNLLGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G0RY48</accession>
    <name>G0RY48_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0005410</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691076.1">
        <property type="nucleotide sequence ID" value="XM_006691013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RY48"/>
    <dbReference type="STRING" id="759272.G0RY48"/>
    <dbReference type="GeneID" id="18254579"/>
    <dbReference type="KEGG" id="cthr:CTHT_0005410"/>
    <dbReference type="eggNOG" id="KOG1274">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004219_2_1_1"/>
    <dbReference type="OMA" id="RYAHTNG"/>
    <dbReference type="OrthoDB" id="427368at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057646">
        <property type="entry name" value="WD40_WDHD1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022100">
        <property type="entry name" value="WDHD1/CFT4_beta-prop_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048591">
        <property type="entry name" value="WDHD1/CFT4_hel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932:SF10">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20946">
        <property type="entry name" value="Ctf4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12341">
        <property type="entry name" value="Mcl1_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24817">
        <property type="entry name" value="WD40_WDHD1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDHD1 first WD40" evidence="9">
        <location>
            <begin position="12"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="230"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 second beta-propeller" evidence="7">
        <location>
            <begin position="418"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 helical bundle" evidence="8">
        <location>
            <begin position="759"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="708"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="737"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS23834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="871" mass="97315" checksum="6005D32B0C052146" modified="2011-10-19" version="1">MASLIASRPRARPAHTHGTTRCAYTPDGTRLVTVGSNNTIRLYKTGFDGEPDNIDDCQEQNLAVAAANTFFVAGAEDGTVSYYSLDTLVFDRFLLRCSLPVRDVALSPDGKWCAVASDELTVRLVNVEDTSRLKTLREHKAPAKHLSFDPSGHVLALSCTDGIIYIYSMTADPPELIRKVDGVIGRVDSDSEVSTRVAWHPDGRAFAVPTPTRDIQVVSKHDGEKQRAFAHGHEGHITALAWSPNGALLATAGKDKKILIWLAKDQSVIARYDYANVIDIAWHPTQNLASFTTSDGEVYICPEFVPEMFENMLRLPKQPAPFIHDPREEITNGRRADAGAHNIPSRPRRPLDDDLDDLLDDGFGGPGGDEDMDDDGFVVDDDGAGYTLNAARKRAAEDDLGAYPNKRSAYFQPQVHPPFQPGSTPWRGNRKYLCLNLVGVVWTVDQDTHNTVTVEFYDHAFHRDFHFTDTFGYDKACLNDKGTLFAAPPKDDRPAVIFYRPHETWVQRTDWRIELPKGESVLALSLSDSFVTVTTSANYVRIYTLFGIPYRVYRPKSTPIVTCASWKDYVLTMGNGPVGPDGQCRLLYSIQDIKHDEMCQNEDTVALPEGASVQSVFFSDQGDPCIYDSTGTLLTLLHWRQPSRAVWIPLLDTKLLPRLASGRKHETYFPIAVADNKFHCIILKGGEKYPYFPRPLLSEFDFSIPLTSAPRGGKKKDKRRPDNPDDEDEFMLSGPSADEEEEEDSTSPESESLRLSQSYLLLSLSYSQLADQLSHNKIPSVSDRARLARLQLDIDKTLLQMLALECRISNGDERSMRALEIVKLMRDRTGKMLEAAGKVAERYGKRVLGEKIKELAEKGGDSDRDEDEEDY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2024-01-24" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0RY74</accession>
    <name>DAD3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DASH complex subunit DAD3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Outer kinetochore protein DAD3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">DAD3</name>
        <name evidence="6" type="ORF">CTHT_0005680</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2018" name="Science" volume="360" first="552" last="558">
            <title>Structure of the DASH/Dam1 complex shows its role at the yeast kinetochore-microtubule interface.</title>
            <authorList>
                <person name="Jenni S."/>
                <person name="Harrison S.C."/>
            </authorList>
            <dbReference type="PubMed" id="29724956"/>
            <dbReference type="DOI" id="10.1126/science.aar6436"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (4.50 ANGSTROMS) OF 18-83</scope>
        <scope>IDENTIFICATION IN THE DASH COMPLEX</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the DASH complex that connects microtubules with kinetochores and couples microtubule depolymerisation to chromosome movement; it is involved in retrieving kinetochores to the spindle poles before their re-orientation on the spindle in early mitosis and allows microtubule depolymerization to pull chromosomes apart and resist detachment during anaphase. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and microtubules. Kinetochores also serve as an input point for the spindle assembly checkpoint, which delays anaphase until all chromosomes have bioriented on the mitotic spindle.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 2 3">Component of the DASH complex consisting of ASK1, DAD1, DAD2, DAD3, DAD4, DAM1, DUO1, HSK3, SPC19 and SPC34, with a stoichiometry of one copy of each subunit per complex (PubMed:29724956). Multiple DASH complexes oligomerize to form a ring that encircles spindle microtubules and organizes the rod-like NDC80 complexes of the outer kinetochore (PubMed:29724956). DASH complex oligomerization strengthens microtubule attachments (By similarity). On cytoplasmic microtubules, DASH complexes appear to form patches instead of rings.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DASH complex DAD3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691102.1">
        <property type="nucleotide sequence ID" value="XM_006691039.1"/>
    </dbReference>
    <dbReference type="PDB" id="6CFZ">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.50 A"/>
        <property type="chains" value="B=18-83"/>
    </dbReference>
    <dbReference type="PDBsum" id="6CFZ"/>
    <dbReference type="AlphaFoldDB" id="G0RY74"/>
    <dbReference type="EMDB" id="EMD-7469"/>
    <dbReference type="SMR" id="G0RY74"/>
    <dbReference type="IntAct" id="G0RY74">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0RY74"/>
    <dbReference type="GeneID" id="18254606"/>
    <dbReference type="KEGG" id="cthr:CTHT_0005680"/>
    <dbReference type="eggNOG" id="ENOG502SCNH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118180_2_1_1"/>
    <dbReference type="OMA" id="WAVINEQ"/>
    <dbReference type="OrthoDB" id="2443965at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0000305"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0000305"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0000305"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990758">
        <property type="term" value="P:mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990976">
        <property type="term" value="P:protein transport along microtubule to mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013965">
        <property type="entry name" value="DASH_Dad3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28017">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28017:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08656">
        <property type="entry name" value="DASH_Dad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0137">Centromere</keyword>
    <keyword id="KW-0158">Chromosome</keyword>
    <keyword id="KW-0159">Chromosome partition</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0206">Cytoskeleton</keyword>
    <keyword id="KW-0995">Kinetochore</keyword>
    <keyword id="KW-0493">Microtubule</keyword>
    <keyword id="KW-0498">Mitosis</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000459475" description="DASH complex subunit DAD3">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P62505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P69850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="29724956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="29724956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="EMBL" id="EGS23860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="9">
        <source>
            <dbReference type="PDB" id="6CFZ"/>
        </source>
    </evidence>
    <sequence length="95" mass="10408" checksum="F73398EB0B619088" modified="2011-10-19" version="1">MDPQARPQSSLLTAAPELSPLEQEVLDEYERLSENMKKLAVLLDELASAPATEILDGLRELERKTSLVFTLLKASVYSIVLQQEIDWGGGAGDGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYG2</accession>
    <name>G0RYG2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH myb-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0006580</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
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        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
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                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <sequence length="219" mass="24900" checksum="A3728E010885674E" modified="2011-10-19" version="1">MTTKNPDELTLDSDNETNNASHGQDESAAVAAAMGFSSFGNPHYIDREEATPPCKKRRFNPGEAAGAQIAEEKQGPVTDQGAQARGLEEGGGRIGYADSDDDDDDNDDDGGAKLEGTTASKIGENQQRQQVWQPQRHQQQWQPYPYQQGQYQYHPQQYGQQLWQQQQHGQGYQQQRLQHRRGQHNPNWYIDYYDPSSNANPWERLEKRKGLEPVGSWLR</sequence>
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                <person name="Flemming D."/>
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            <begin position="1"/>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="339" mass="37359" checksum="7FD57EF2B21077FD" modified="2011-10-19" version="1">MASLFGSLKKKIKSRSPSPNPGAPGSPTLGRKGSFVKNNPFASSSPPTAEPFLNLQDNNDPPPPSYAEAIGQDSSSSPFISLRSASPAPSIRSYLSTSEDKYAFLRKFDTKFLIDDSGSMQGRRWQEVAGVLRAITPICTERDADGIDVYFINHNAPGGYKNIRTPEQVDQLFRSTKPIGGTMTGWRINQILLPEVVKFEEAVRTLKKQMKNKDAIIDTTEIDVKPVNLIVITDGEAQDDVESYIKALAQRLDNVSAPAWQIGIQFFQVGDDAKADAALRQLDDGLTGVRDMVDKVSWTDREGSEKTLSADGILKTVLGAVHRRLDRMEVESSRRYLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYL5</accession>
    <name>G0RYL5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0007120</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS24001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691243.1">
        <property type="nucleotide sequence ID" value="XM_006691180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYL5"/>
    <dbReference type="STRING" id="759272.G0RYL5"/>
    <dbReference type="GeneID" id="18254750"/>
    <dbReference type="KEGG" id="cthr:CTHT_0007120"/>
    <dbReference type="eggNOG" id="KOG1620">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001850_1_0_1"/>
    <dbReference type="OMA" id="WGATMVN"/>
    <dbReference type="OrthoDB" id="2573163at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000824">
        <property type="term" value="F:inositol-1,4,5,6-tetrakisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008440">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF21">
        <property type="entry name" value="KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="131"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="615"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="690"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="754"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="807"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1106"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1209"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="307"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="348"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="365"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="420"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="434"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="447"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="504"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="523"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="640"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="692"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="754"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="833"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="850"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1109"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1221"/>
            <end position="1233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS24001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1233" mass="136566" checksum="94CC75ED62EA7B26" modified="2011-10-19" version="1">MATLNRDRPLRQRRLGRCQVSWNTPRPGQRSPYRVALTGQGTLKQDQKRPEESTLGQPVDRPRCLREPVDELHEPRTSKTIQRVAPDVGSMSNPPLSDDAASAAGVSDSHAHTRPAAYDDAAALQIEAGQVPQEPQPQRQSQTQAQPQPQEHQPPHTPEPIKYTRGPTLQRPSGPSLLTQALATARGIPRDKQISAFSSSQPTSQDKDNEGRHESSTPRSSPRKTTMHGRLDLGEVNSRLLNGEHCDRERDGRPPQPARPLPEKVWSIGAGDAGIGEDGKVEKSISEVLAGVEPNNRSRKASHSLRFFKEGLPDEQRPKKKEHKSEKLQEIQERSVDEKLKSGGDNGTGSHIRSQAAFPSSSEKGIGRDIPPEDQAVKKPEGDNVVSVVGSPPSSPGAGDSEEGQESGEEQISSAVRHSRHDDYHPWLVKADEPEPDEEELEEERGEDEHEPAQEHKDKDKDKHKHKQRRIKSDAADGCPTVAPEVALRQVDQPTPTPTPAPHDDDDDDDHDDVDDESERSARAQSSSSSAPYHEEAAYDHYYNAPRQPLEAIELIPYKHQVGGHTTLWRFSKRAVCKQLNNRENEFYEKIEKYHRDLLRFLPRYIGVLNVTFQKQPRRKSTKREDAGEPQAESQAGAAETSQDGQPRMVSQSMQSTAGQIPTVTFVDNRHILPRNLLQPSLPPLAGRFRSASESVRGATSGNDSSQGSAAAIQNESSRTGQQERPNSWGATTVNKKLRNEVFNDAFLKQPIAIHRHRKGHHRPFPRPRPVVGSEGAGTPASAANGIDVPLPKSAIDLAHADRYAADDELGPRDITGTSAPEPEILGDTSPAQRKKKRRYSGSGLRRKPKDVQDGRGDLEYFEEADDVDYKSARGDVPSREELKTALSQRTSTVASTVSSTAIPTASTSPAPLSTTASADGTVGNAVVPNGNGQHLAPVPYKIPRPLNPKEAQTQRNTRVEYFLLLEDLTAGMKRPCIMDLKMGTRQYGVDATPKKQKSQQGKCAKTTSRELGVRVCGLQVWDVKTQSYVFKDKYYGRELKKGAEFQAALTRFLYDGVDKASILRHVPTVLRKLDELEVIIERLRGYRFYAASLLMFYDGDQSSGVANGEDETTDFTTDAEEVHQQPQHGNGAAAQQPRRTRKSRREIDFKMADFANCVTAGDGIKDRPCPPRHPGEPDRGFLRGLRSLRKYFLKIQRDTRVELGLAAPFRNGNGEKDEWTWEDSEEEGSVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYX9</accession>
    <name>G0RYX9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Iron-sulfur assembly protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0000960</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the assembly of mitochondrial and cytoplasmic iron-sulfur proteins. Probably involved in the binding of an intermediate of Fe/S cluster assembly.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690649.1">
        <property type="nucleotide sequence ID" value="XM_006690586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYX9"/>
    <dbReference type="STRING" id="759272.G0RYX9"/>
    <dbReference type="GeneID" id="18254134"/>
    <dbReference type="KEGG" id="cthr:CTHT_0000960"/>
    <dbReference type="eggNOG" id="KOG1120">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069054_0_0_1"/>
    <dbReference type="OMA" id="MPRVHET"/>
    <dbReference type="OrthoDB" id="333486at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.300.12:FF:000001">
        <property type="entry name" value="Iron-binding protein IscA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050322">
        <property type="entry name" value="Fe-S_cluster_asmbl/transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072:SF41">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="5">
        <location>
            <begin position="155"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="43"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="95"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00054873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00071673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS23407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="258" mass="28454" checksum="7C347025E023ECA7" modified="2011-10-19" version="1">MNAPSVFSRRSASVCLACRRSMLHRQFSTSPASMVTAFQAYTLPSHPPPPRSGVTETITPIQTPLPRVHETRPPRGLGPELHQPKEIPTTAKQDTIAQSTAAQQHQSQFQSQSSSVSTEKTQTTASIQQSAPSTTQQQPSARPRSRLRTPRKAAMTLTPAAVAHLRELLNQPEPKLIKVGVRNRGCSGLAYHLEYVDKPGPFDELVEQDGVKVLIDSKALFSIIGSEMDWVENELSQRFVFRNPNIKEQCGCGESFMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZ00</accession>
    <name>G0RZ00_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="15">III C-methyltransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0001170</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Siroheme synthase involved in methionine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>uroporphyrinogen III + 2 S-adenosyl-L-methionine = precorrin-2 + 2 S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32459"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.107"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690670.1">
        <property type="nucleotide sequence ID" value="XM_006690607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZ00"/>
    <dbReference type="STRING" id="759272.G0RZ00"/>
    <dbReference type="GeneID" id="18254155"/>
    <dbReference type="KEGG" id="cthr:CTHT_0001170"/>
    <dbReference type="eggNOG" id="KOG1527">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011276_2_2_1"/>
    <dbReference type="OMA" id="TPCAIVE"/>
    <dbReference type="OrthoDB" id="508204at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1010.10:FF:000006">
        <property type="entry name" value="Siroheme synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.950.10:FF:000005">
        <property type="entry name" value="Uroporphyrin-III c-methyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012066">
        <property type="entry name" value="Met1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050161">
        <property type="entry name" value="Siro_Cobalamin_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790">
        <property type="entry name" value="SIROHEME SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790:SF6">
        <property type="entry name" value="UROPORPHYRINOGEN-III C-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13241">
        <property type="entry name" value="NAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036555">
        <property type="entry name" value="SUMT_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75615">
        <property type="entry name" value="Siroheme synthase middle domains-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="2 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Siroheme synthase central" evidence="14">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="13">
        <location>
            <begin position="332"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS23428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="613" mass="66679" checksum="61A6974AEB444E89" modified="2011-10-19" version="1">MPQLDPQSSQPPDPSTSDSMAKSYQPSLLTALHCHQHIHLIIGLSPIAFSRAQSSLLANAIPILIAPLPDGTQSVEDAGVHHNLVTLINEGRVKHLNRAFNPEKDPFELGRDEVGKVVDAVFVVSTPEGTLAPGWTRERVAELCRRNRIPINVLDSPQLSTFSLLSVHNDGPLQIGVTTNGMGCKLASRIRRELASSLPKGLGEACERLGRVRRRIIEEGEVPEQGEGEGDDSLEQGRGLNRLVLEGSVEERKGRRMRFLAQVCEYWPLKKLAGVTEDEVRAVWEGYLRGEGQQNGTHKGQQNEAILREQQIRAQVDQNGSHTSQAQGLGLIILAGSGPGHPSLLSRATHTAILTADIILADKLVPSGVLDLIPRRTPVQIARKFPGNADAAQEEFLTLALSHLRQGKTVLRLKQGDPFIYGRGGEEVAFFREHGVPEEKIVVLPGVTSALSAPLFAGIPATQRDVADQVLICTGTGKKGKPPAPPEYVPSRTVVFLMALHRIEGLVAELTSPTAEELENSKGGNRAFWPINTPCAVIERASCPDQRVIRTTLKWVVQAIEVEGSRPPGLLVVGRACEALWTKGGKERSWVVEEGFRGLEWEGVERALEGLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZ89</accession>
    <name>G0RZ89_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0002110</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690759.1">
        <property type="nucleotide sequence ID" value="XM_006690696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZ89"/>
    <dbReference type="STRING" id="759272.G0RZ89"/>
    <dbReference type="GeneID" id="18254249"/>
    <dbReference type="KEGG" id="cthr:CTHT_0002110"/>
    <dbReference type="eggNOG" id="ENOG502RMX2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082768_0_0_1"/>
    <dbReference type="OMA" id="TIEQHLM"/>
    <dbReference type="OrthoDB" id="3598799at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="293" mass="32748" checksum="AC58B0A2B204706B" modified="2011-10-19" version="1">MTTASPNRPAVSRGRTTRPGKGTPPTDGDVDDDDLTSQTQPKKPRRAAASQRTKGGDEENELLDFTSLKHGSFKPATIEQHLMEQSQRAKKFIQEFKEKIATRQDQFLETLVKLKQVLHNPSAQGDDPTNIYIAMRRLSAAIEPVAISFKDNPLYEETQKVLHLSHDLLQRHEKANSEFNQNSAALKTPREMWKQDEESLKKLLECGRIHGEKIVEGWITPEDGKSQGESEDEDDGDDASLGGNLGEVKDLAKGLYKWKKEELKGEEAWGVAAKKQMVALVGLLKTLPAPRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZQ6</accession>
    <name>G0RZQ6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-1,3-glucanase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0003810</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690926.1">
        <property type="nucleotide sequence ID" value="XM_006690863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZQ6"/>
    <dbReference type="SMR" id="G0RZQ6"/>
    <dbReference type="GeneID" id="18254419"/>
    <dbReference type="KEGG" id="cthr:CTHT_0003810"/>
    <dbReference type="eggNOG" id="ENOG502RZ85">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019141_1_0_1"/>
    <dbReference type="OMA" id="WVEILTW"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409162" evidence="1">
        <location>
            <begin position="29"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="444" mass="49067" checksum="710BC82F71C57B98" modified="2011-10-19" version="1">MGGFRFKLSAFLLISFSLHIYAIKEVFAHVIVGNLRTFNFTDWVSDIRIAQSSKIDGFVLNIAAHDPSNEHSLDLAFEAASAVGNFKLLFSFDYRAQGPWSRDAVTELLRKYTRHPAYFKHDGKRPFVSTFEGAECAEDWPAIKAATNAFFVPDWSSVSAAHAVKLAGGVVDGLFSFKAWPSGRENMTTDMDDTFRAALGARRVYMMPVSPWFYTNLPGFGGKNWMWRGDGLWDRRWRQVIKIQPDFVQILTWNDFGESHYIGPIPEKALGLFQVANAPINYAQGVTHDGWRKFLPYYIEVYKTGKAPQQVDENVYAYYRTTPAYACPNGGTSGGSAAHGESVMPPEHLVDDNVFFSTLLNTDHGVTITVRIGDNEQTGVFTEFPAAGRGTPGVYTGSVPFAGRTGDVVVAVLRGSKVISRIGGGKPIANICENGTQNWNAVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0S012</accession>
    <name>G0S012_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Asl1-like glycosyl hydrolase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0008360</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691364.1">
        <property type="nucleotide sequence ID" value="XM_006691301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S012"/>
    <dbReference type="GeneID" id="18254874"/>
    <dbReference type="KEGG" id="cthr:CTHT_0008360"/>
    <dbReference type="eggNOG" id="ENOG502RXK9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040908_4_1_1"/>
    <dbReference type="OMA" id="SHKRGVC"/>
    <dbReference type="OrthoDB" id="43654at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF13">
        <property type="entry name" value="ASL1-LIKE GLYCOSYL HYDROLASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409164" description="Asl1-like glycosyl hydrolase catalytic domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="3">
        <location>
            <begin position="169"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS23173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="397" mass="42947" checksum="676AAF0484554FEC" modified="2011-10-19" version="1">MHSNIFLLLAVAGLAGQALAAIPGGHGHLHGHQKRALVTEVVTVTDWVTVTVTLDFNPHTRFYTNKGKTKDWKTKQISTSTFVEAAALSTPNPAVPTTIVTQVISADPAPEVSPLPAAESVVPPPLPPPPASTQSTVVENVQSAPSANPGVAEDENSGSNSHGSSGKRGLAYNDPTLLKRFVNSGTKISWTYNWGQYDDSGLDLEFCPMLWGLKLDFPQIWPTNAQKAIGAGSRCLFSFNEPDLDSQANMSPELAAQKHVELMNPFAGKAKIGAPAITNSGAPHQGIGWLQKFFNACNGQCAVDFVNIHIYGVDTKTFLNHVLNVYSTFKKPVWITEFAFDGTEEQINAQLTEVIHQLENNATFSFVERYAYFMVSEGHLVRGNTLSVYGNTFAYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0S040</accession>
    <name>G0S040_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein/NADH dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0008640</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691392.1">
        <property type="nucleotide sequence ID" value="XM_006691329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S040"/>
    <dbReference type="STRING" id="759272.G0S040"/>
    <dbReference type="GeneID" id="18254902"/>
    <dbReference type="KEGG" id="cthr:CTHT_0008640"/>
    <dbReference type="eggNOG" id="ENOG502SDFJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094283_0_0_1"/>
    <dbReference type="OMA" id="FWREMLP"/>
    <dbReference type="OrthoDB" id="1696305at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040049">
        <property type="entry name" value="Ribosomal_mS25/mL61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13274">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13274:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="6">
        <location>
            <begin position="40"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="89"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="143"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS23201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="202" mass="22795" checksum="480AD42A5E357640" modified="2011-10-19" version="1">MVGVIRRLNRLKALVKLRVGPGAALLPEDVTRIHMEFAMKHNDGHMGPRKFWREALPRLKYWNPQIPMIVNRHRDQSAPATLSIYFRKPGATITKETPTPPSATDGSSKAPPPSEGESVVTIDMKNRHSDVILQEFLEKTKAQLLKPTPQDEQELLDAKQREEQGAIDRERNRKRLEEEKREKALMAAAQAEAAAIRAAAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0S044</accession>
    <name>G0S044_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-rRNA processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0008690</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691396.1">
        <property type="nucleotide sequence ID" value="XM_006691333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S044"/>
    <dbReference type="GeneID" id="18254907"/>
    <dbReference type="KEGG" id="cthr:CTHT_0008690"/>
    <dbReference type="eggNOG" id="ENOG502QZVV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006918_0_0_1"/>
    <dbReference type="OMA" id="HYNITKL"/>
    <dbReference type="OrthoDB" id="5596576at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059065">
        <property type="entry name" value="Ig_Tag1-like_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059066">
        <property type="entry name" value="Ig_Tag1-like_5th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046368">
        <property type="entry name" value="Tag1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055011">
        <property type="entry name" value="Tag1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895:SF3">
        <property type="entry name" value="PRE-RRNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26174">
        <property type="entry name" value="LEA-2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26150">
        <property type="entry name" value="LEA-2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26153">
        <property type="entry name" value="LEA-2L_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22786">
        <property type="entry name" value="Tag1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Tag1 C-terminal" evidence="3">
        <location>
            <begin position="452"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Tag1-like fourth Ig-like" evidence="4">
        <location>
            <begin position="575"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="Tag1-like fifth Ig-like" evidence="5">
        <location>
            <begin position="720"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS23205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="842" mass="90486" checksum="4F50E6ED8BA5460F" modified="2011-10-19" version="1">MSDASERSPLLSNHRAERDETQQVIESTPLLSTAATTLRYDGQTDGDASHDADPTSMTGRSSGPVSSKASKSKRIRWPSVIAVIVLSLFAVAVVVLGFVVPSAVEEYAKQAAVLEPTDLSLVSITAEGVRVRIQANFRLDAQRVPDGRVRSIGKTVGWLIGEIKTGPTRINVYLPQKNDMLLGTAAVPPLSVSITAGQNNAIDIVADLIPGEAESIRTIANEWLQGRLKTVQLRGQADVQLTAGSKLPHMPKYNITSLNVRDDPLPGHEGKTIAVEVSILTFNEYPISLDVPELAFEVLVPGCTAAAPSILVAAATTNAIAVRAHSDVIVDVRGSLVQLPDSLTRPCPDSDSSPLDMLFEKYLGGKPATVFVRGQKQPVAEVPGWIIELLSSITVPVALPGRPLDNLLREFSLSDVSFDMPDPAADPEDPRSKPRVSGTIVATAELPAELDLTLNVTGVRANSDVFYRGRKLGELKLKKWQKATSTQLPKKTGQHAALLKIQARINNAPVDVTNPNVLTDIIQSILFGKDVILGIKALVDAKVQTVLGDLMIKAIPAEGKFPIKPPEGGFLHSAVPEVSIMKVTNTTSTTLSFDALVNVTNPTLYSAHIPFISVHIESNGTTIGEVHAKKLNIRQGRNTNLVVSATWNPEMGGKEGLQRGRDVISQYLSGFNTSFIVRTHRGTIPTLPLLGEALAQLNITLPAPRFACSDGAGSDKNNPEGPCFIRDATFHLLSSTATFTLVSPLRDTTIFIDNVDATALYNHSEPLGRIRYYLPFAAPPGASTTPKLPVEWSFDSIGYGKLRDALGGRMKVDAKADVGVRIGQWTERVWYIGKGIGASVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0B6</accession>
    <name>G0S0B6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0009440</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691468.1">
        <property type="nucleotide sequence ID" value="XM_006691405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0B6"/>
    <dbReference type="GeneID" id="18254982"/>
    <dbReference type="KEGG" id="cthr:CTHT_0009440"/>
    <dbReference type="eggNOG" id="ENOG502STXT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095402_0_1_1"/>
    <dbReference type="OMA" id="HPHFPRT"/>
    <dbReference type="OrthoDB" id="4156665at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="189" mass="21424" checksum="B2773A38159E5C02" modified="2011-10-19" version="1">MEHSSPQQPNSSNDYQPSPTATNSTSSVAPMTSTASALYARRAAKNPPFEAKIQHMSLKLAPLVQLTTGLVHPNFPRTLLAFWLLTEDQLDDLAHFYHQRTPCEWTQHYPCPVSWPPGLTLEEKRRKLGKFIGLRGCDTPIEQLVRDDVAKAMERSEEDIERDAAEVRRRGGTSSGDDMDEIRRKMGWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0M2</accession>
    <name>G0S0M2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0010510</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691574.1">
        <property type="nucleotide sequence ID" value="XM_006691511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0M2"/>
    <dbReference type="STRING" id="759272.G0S0M2"/>
    <dbReference type="GeneID" id="18255089"/>
    <dbReference type="KEGG" id="cthr:CTHT_0010510"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_296464_0_0_1"/>
    <dbReference type="OrthoDB" id="5139479at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF77">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="522"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="965"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS22582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1018" mass="113506" checksum="0E6725367331DCC1" modified="2011-10-19" version="1">MDEKRAEFKEAMRIKPAYSTTEFSKQCWGYPHSPDEASNPGVTVIQEGQPQQPQLPETDADHEEQRTNTREVFPLLALWAFAVVFSLLYSFFVYKSMLSHDPKIGDQLPLASTTNLVVSVLSQVLANMIDMLVTGSFDMLRWQLAARKIGVSATTFLQLSSSTQWISVLFLTVTKMSNKAEFVYFFSETASRTPVFAGSGIPVDETLLAIVPGSYIGLFFMSWIPTLLDVPKYAVPMPIDSCKENCTSVFLPGGIETARIAGPYLNRTLLEGGALRNAETIQIHNAPGVLLTYQTLGPEFKFDFVTECALYGQQLDDILQICIKAINGSLAVGWAACPTSIYTAKACTTNTTWLYNPLTKQVLMTRYKRYATVSYNGNDFTIVNVEPTSPLHPEPLNVTTYLAAFQKLFIPPPPFTADISTSNTATPIEAHIVNALTYGITWLIRLYDDMFPDDMQTPLSHLRNFLAIPHQFMVTCLQYANYSVTPELARVLGKEGRFSLPSDMQTFASRGVSTTRFLGVRWVVWVYIASVAGVLVVIGAMIVGMALREDGIPASTGFVEVDLAARFQGRGDDGRLGGFEDGLDGLRELKSAKAVKLAAPTSFNVARELKRRRIRVMPVAGQGGKARLASPDPAQVAMVNVLDTAVHDKLKAQTPGYAGREVPGLENDIDSVLAMVVDKLRTKYAVIGREDRGKKPLLEFASLATYFTLDSTAKISFGKDLGHIKEEKDVYGYIEGMEKLSPVLAVIMVVPYLRWIFSSKLVVWWLSPKPWDKKGIGAIRRKRFAEKVEMEDHKDMLSSFIRHGLSQRQCEIEAMIQITGGTDNTSTAIRSIMLYLLATPHAYQALQAEIDEGIRTGKISNPVTYSEEQQLPYLQAVILEALRLHSPFVGIPLKKAPPEGDVINGKRVPGGTLVSANMWLVGRTKRVFGGDEDIFRPERWLEADAAQRAEMRRAAELFGAGRWLCSGKLIAYMELNKFFLFRHFDFQLANPLRPWHSESYGFHFHNDMWVSVSWRQNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0U8</accession>
    <name>G0S0U8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endoplasmic reticulum junction formation protein lunapark</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0011300</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in determining ER morphology.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the lunapark family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691650.1">
        <property type="nucleotide sequence ID" value="XM_006691587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0U8"/>
    <dbReference type="STRING" id="759272.G0S0U8"/>
    <dbReference type="GeneID" id="18255168"/>
    <dbReference type="KEGG" id="cthr:CTHT_0011300"/>
    <dbReference type="eggNOG" id="KOG2846">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039522_1_0_1"/>
    <dbReference type="OMA" id="PKWYDRI"/>
    <dbReference type="OrthoDB" id="1725934at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098826">
        <property type="term" value="C:endoplasmic reticulum tubular network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071788">
        <property type="term" value="P:endoplasmic reticulum tubular network maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903373">
        <property type="term" value="P:positive regulation of endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040115">
        <property type="entry name" value="Lnp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019273">
        <property type="entry name" value="Lunapark_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166:SF12">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10058">
        <property type="entry name" value="Zn_ribbon_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Lunapark zinc ribbon" evidence="4">
        <location>
            <begin position="251"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="138"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="327"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="346"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS22658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="371" mass="40849" checksum="6E7B6AEE3D4F836F" modified="2011-10-19" version="1">MVSFWPWGKDDTSPESFEKALSALTTKITAAQTQLDQTRAKGRRVMVLSTLYLGFAYLVYAIVLILVVGWRNMGAVDWTAVLGGPILIVVVRTVITDFVNYRTKRLSSRLKDLQAERAKTIQKLKDATKYESTLELLQKYGGPENKEKRGTLGAEEDESRIQQQGGRPKDTQAPLANRINILPPPTANIQRPLVPRPVTPQPRPHANPAMPEIDVSAEFAPNAFDGRPPPAYMQYPPATMTAAPAEPKSHWYDRILDTLLGEDETAAKNRIVLICSRCRLVNGQAPPGTKSLTELGLWKCMACGAPNGEIDEGKRIVQEVLGNRAAEFTAEAPKDTTSRSSSDLVEVDKEVPVKEVEERQSSAEESGKSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0S158</accession>
    <name>G0S158_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative cytochrome P450 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0012430</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691760.1">
        <property type="nucleotide sequence ID" value="XM_006691697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S158"/>
    <dbReference type="STRING" id="759272.G0S158"/>
    <dbReference type="GeneID" id="18255281"/>
    <dbReference type="KEGG" id="cthr:CTHT_0012430"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_338584_0_0_1"/>
    <dbReference type="OMA" id="DMTMDSS"/>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002974">
        <property type="entry name" value="Cyt_P450_E_CYP52_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF17">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01239">
        <property type="entry name" value="EP450IICYP52"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="787"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602402-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS22768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="840" mass="92900" checksum="5E46AD864D6516E8" modified="2011-10-19" version="1">MYNYSTGLAREIWRERTQGLLLGTRVFFRGEERTIMSEVACEPVDLCDIDQQSFKAYLARAMAATTKWAPWTYDIIKPLLEESAKAAVSTCTGGDNGRMCGLKWTEAGVHDNLTGVGQQMAAMEVVLANLIDQAAPPATRNSRGTSLGGAAAGDINAVANEKVSQPIPAAGKAAAYALTALAVIGLVAGCLYVLIEERVSLRPLRSVLASGKSNSFDQLLPTSGVKSKESSDDWSSSETVIIRRPDNAANPPGRLSFWTRLKRLTIAANVNADNQAMSSIQQPDWGSGNGTGGNSVPHFSVPLGVKRENLSNSMEYIPAAALSVPLSVLGLLRAYNSLIVDSSRITISSYVLLLGLVAAAVKLNLSLINRYRFEARARALGCGKAPVYPHKDPILGLDSFFEGLRNFKDHTLLNWYFRRFTKCGSTYWSKTLGSWLLMTDDVENIKTILAAKFDDWPIAGPRLLGTLPVLGPDSIFSTNGAAWQHARTMIKPAFVRDQVADLQCFDRHIRNFLAAIPKDGSAFDIQELLLDMTMDSSTDFLMGYSTNQLTTPSPEARQFVEDFEFASRESSKKARFGPILYKLPHPELEAAVRRMREYIRFYLKKAAEEKKGLEKERNYVFLDELLKLNPPEEYLIDQALTILVAGRDTTAAAITGVFYFLARHPDVVEKLRAEIMAVDEERPAWEKLKQMKYLNNVIKEALRLFTPVSTNSRSAIKETILPRGGGPDGAKPILVPKGTPIRYSLHSLHRSKDIFGPDAEEFRPERWDGDFRPGWGYLPFSGGPRICLGQQFALTQIAYTLFKFFRVFKAIEARDSQPLLAKVNLTISFPNGCRVSVTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0S177</accession>
    <name>G0S177_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chitin biosynthesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0012620</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691779.1">
        <property type="nucleotide sequence ID" value="XM_006691716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S177"/>
    <dbReference type="STRING" id="759272.G0S177"/>
    <dbReference type="GeneID" id="18255300"/>
    <dbReference type="KEGG" id="cthr:CTHT_0012620"/>
    <dbReference type="eggNOG" id="ENOG502QRF7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019904_0_0_1"/>
    <dbReference type="OMA" id="ACEQNGR"/>
    <dbReference type="OrthoDB" id="245697at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034044">
        <property type="term" value="C:exomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13945">
        <property type="entry name" value="Chs5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000453">
        <property type="entry name" value="Chitin biosynthesis protein CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.120.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031673">
        <property type="entry name" value="Chs5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052827">
        <property type="entry name" value="CHS_Export/Cell_Fusion_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031669">
        <property type="entry name" value="Fn3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351:SF1">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16892">
        <property type="entry name" value="CHS5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16893">
        <property type="entry name" value="fn3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="76"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="164"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS22787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="399" mass="43339" checksum="00F34574063634EE" modified="2011-10-19" version="1">MGVVSLTVGKVDAGVTVLLTPDKRLIEFPSILLPPDIRSGSIVDINVSRNKSSEAAAERAFRDLQDQILSSFGTHSPSPPTLRVRNTTQTSVVLEWDPLQLATADLISLSLYRNGQKAGTIPKPLTMHTTKISGLAVDTEYTFHLVLRTTAGTYASPRITVRTHKMTDLSGITITTGILPSHVRENLLAVVERIGAKVVDGVRIDTTHFVTTEGRGVQWEKANELNIPVVRPEWVEACERAGRILGVTKFYLDAARVGALFDERPGTAGTVGSGSAPPPPPPPKEQKVQSPVQTRTEVTVEKPKEESPEPASGSEKEQQQQKEEGEKKADEQSSQSAEEKPLPSRPKVTVEDEKEEEEKEEEKEKEKAKAPAAEEKEGSSGDEKDGKSPGDSSFQDVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0S199</accession>
    <name>G0S199_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF803 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0012840</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691801.1">
        <property type="nucleotide sequence ID" value="XM_006691738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S199"/>
    <dbReference type="GeneID" id="18255322"/>
    <dbReference type="KEGG" id="cthr:CTHT_0012840"/>
    <dbReference type="eggNOG" id="ENOG502QQG9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_756501_0_0_1"/>
    <dbReference type="OrthoDB" id="2504919at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF86">
        <property type="entry name" value="ADR321CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="257"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS22809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="39883" checksum="75CE744E29598621" modified="2011-10-19" version="1">MGLIDGISPGGSLALGIIVGAVLIATFGTIPSPAHKLSELLELLSRKPFVIWMSFQAVIIVGLALATDIVSYFTTLMQDHRFRLTRGFSYGFISGTLSAHSLLFAKSAVELLVRTIVNKDNQFVHWQAWMIVVGLLILALTQLYYLHRGLKLVSTSVLYPFIFCIYNIIAILDGLIYFRQTDLINPLRACLITLGTVILLSGVLSLSWRLTDEQHPPAIGQSTLAPGLGLVEDTEGEEDFEEDVSLHSALLDNEERSNLDTVPLPSYQTFGSPPAPSPTIFTQPTTPGTRSQTLMSRSRLRSTPSRWQDAGIWGELDDRSTTAPQSPAVSKRRLASMPITTNRSGEEAEPLLGGTRRSLGGGGGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1C6</accession>
    <name>G0S1C6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0013120</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PDCD5 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691828.1">
        <property type="nucleotide sequence ID" value="XM_006691765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1C6"/>
    <dbReference type="STRING" id="759272.G0S1C6"/>
    <dbReference type="GeneID" id="18255350"/>
    <dbReference type="KEGG" id="cthr:CTHT_0013120"/>
    <dbReference type="eggNOG" id="KOG3431">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122978_1_0_1"/>
    <dbReference type="OMA" id="MQYEMQK"/>
    <dbReference type="OrthoDB" id="10252486at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.140">
        <property type="entry name" value="PDCD5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002836">
        <property type="entry name" value="PDCD5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036883">
        <property type="entry name" value="PDCD5-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10840">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10840:SF0">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01984">
        <property type="entry name" value="dsDNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015730">
        <property type="entry name" value="TFAR19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46950">
        <property type="entry name" value="Double-stranded DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="130" mass="14942" checksum="965885BC291BBCEF" modified="2011-10-19" version="1">MEDAELERIRKARLEQLKAQSAARPGATNGADQEQRKQREAEARQAILNQILEPEAADRLGRIRLVKEQRATDIENRLIMLAQTGQLRQKVTEDQLKELLNAVADTKEEEKIVVSRRKGWEDEDDDLLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1G4</accession>
    <name>G0S1G4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone chaperone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0013510</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms a chaperone-bound H2A.Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A.Z histone replacement in chromatin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Forms a heterotrimer with H2A.Z-H2B, stabilizing the association of the histone dimer. Also, with a lower affinity, forms a heterotrimer with H2A-H2B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CHZ1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691866.1">
        <property type="nucleotide sequence ID" value="XM_006691803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1G4"/>
    <dbReference type="STRING" id="759272.G0S1G4"/>
    <dbReference type="GeneID" id="18255389"/>
    <dbReference type="KEGG" id="cthr:CTHT_0013510"/>
    <dbReference type="eggNOG" id="ENOG502SCUM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130004_1_0_1"/>
    <dbReference type="OMA" id="MEGVQDP"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019098">
        <property type="entry name" value="Histone_chaperone_domain_CHZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09649">
        <property type="entry name" value="CHZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01082">
        <property type="entry name" value="CHZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone chaperone" evidence="8">
        <location>
            <begin position="66"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="37"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS22874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="123" mass="13753" checksum="4EBD9E72CC247453" modified="2011-10-19" version="1">MATENGNDDPVTLAETTEVAETEVTDVKGKGKAVATEELEDTSMVSVEEDDEDDDEDDDVDEEDAEVEEDNLEEIDPENIVGRRTRGKVIDFAKAAQENPPKDDDDDEEDEDFHVDEDKMDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1U5</accession>
    <name>G0S1U5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Long-chain fatty-acid-CoA ligase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0014850</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS23005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691997.1">
        <property type="nucleotide sequence ID" value="XM_006691934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1U5"/>
    <dbReference type="STRING" id="759272.G0S1U5"/>
    <dbReference type="GeneID" id="18255523"/>
    <dbReference type="KEGG" id="cthr:CTHT_0014850"/>
    <dbReference type="eggNOG" id="KOG1177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_7_1"/>
    <dbReference type="OMA" id="ICCRGYN"/>
    <dbReference type="OrthoDB" id="10253115at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000008">
        <property type="entry name" value="2,3-dihydroxybenzoate-AMP ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF30">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="111"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="572"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS23005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="681" mass="73780" checksum="41EA9CF0E010DAFA" modified="2011-10-19" version="1">MRLHSMSTTRLLYVSAARNSLLCRYVHASTPKGSWHVTRTKSRRAGRTLSTLTRSISQGPTETPLLPHTIPEHFSSIVSQFGDRPAVISRSPAISQDGFPNLPPGTLLSSVETTLTYEKLDLASNALAQSLRSLGVKKGDRVAMSLGNCAEFAALTYAIFKLGAILVPLNPSFNANQVTAALNHLGVEILIISAVTDLAYKPCRGRSNFPLLQEIVSDLSSGKVESATIPTLKKVVVVDNSGSHPQSNFPSLDTLRSLIPFNSLLPSGPDLTNIAAQSARPITPDSPLSPSDTINIQFTSGTTSQPKAAMLSHTNILNNGNLIAQRMGLDPSDLIVCPPPLFHCFGSVLGYMATATTGAAILFPSPAFDPVATLRMAAAHRATGLYGVATMFVAMFEALHNHLIPADQATALPTHLRKGIAAGSSVPESLMRKIYATLGLNELVICYGMTETSPDSCMTSPRDPFDKRTQTVGRVMPHTKVKIVDPADRSRILPIGERGELAASGYLVMKGYWGDEEKTAEVRIVEKNEEGVEEVWMYSGDEASMDAEGYVEITGRIKDLIIRGGENIHPLEIENCLFQHPLVAEVSVVGVPDEKYGECVGAFVIVHEGVRAEEEEGAVVSEGEEKVLTKEDVREWVRKNLSNHLVPKHVWFVKEYPKTASGKIQKFKLRDMAKELVAAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1U8</accession>
    <name>G0S1U8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA/RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0014880</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS23008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692000.1">
        <property type="nucleotide sequence ID" value="XM_006691937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1U8"/>
    <dbReference type="STRING" id="759272.G0S1U8"/>
    <dbReference type="GeneID" id="18255526"/>
    <dbReference type="KEGG" id="cthr:CTHT_0014880"/>
    <dbReference type="eggNOG" id="ENOG502QRU3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010014_0_0_1"/>
    <dbReference type="OMA" id="EETWMEC"/>
    <dbReference type="OrthoDB" id="2017974at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000202">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.7, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018834">
        <property type="entry name" value="DNA/RNA-bd_Est1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF0">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN EST1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10373">
        <property type="entry name" value="EST1_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA-binding" evidence="2">
        <location>
            <begin position="198"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="323" mass="36948" checksum="A981D4B2FA7E24A3" modified="2011-10-19" version="1">MQAPPVTFSTETSARSSNSNNEILRQPETKAITAEQLVTEVKGIYAGLVMVESKCIEVDNAQNAAHNDLSNKLSDEQWQALIALHRTYLNEHHDFFLASQHPAATPALRRLPAKYAMPARMWRHGIHSFLEVLRHRLPASYEHMISFIYLAYSMIALLFETVPAFEETWMECLGDLARYRMAIEDDDIRDREIWAGVSRQWYSKASDKSPTTGRLYHHLAILARPNAVQQLFYYSKSLCVEIPFVAARESIMTLFDPIMSPTPNPQQMKLARPELLFVRTHGILFCMLAGKQPREDPEAPMSEMLQWLDSHIARSTLSWRSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>G0S223</accession>
    <name>G0S223_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0015720</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS23083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692075.1">
        <property type="nucleotide sequence ID" value="XM_006692012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S223"/>
    <dbReference type="GeneID" id="18255610"/>
    <dbReference type="KEGG" id="cthr:CTHT_0015720"/>
    <dbReference type="HOGENOM" id="CLU_1354456_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408836" evidence="2">
        <location>
            <begin position="20"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="202" mass="21283" checksum="5605807C2392BC6A" modified="2011-10-19" version="1">MKLSKSLFFSTLLAGFAAAKGPIMELEGNFDFGHDHSHESYGHSGGYGYGYGNGYGKPDGSWNNPSSSKDVPAAANSYIIEEPSEASYYPQTTFPQPTETPKSDSDDGKYPPVEDYGQFEPTPTGSFYFEDNGEPTPTPVASVYDDSYPAAPTSPGYQYNQTSLHPSGGPYSETIVSAGSGRAGLKFAVTLAAAVAAGLGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0S245</accession>
    <name>G0S245_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL30m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0015940</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EGS23105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006692034.1"/>
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    <dbReference type="STRING" id="759272.G0S245"/>
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    <dbReference type="KEGG" id="cthr:CTHT_0015940"/>
    <dbReference type="eggNOG" id="ENOG502S7S3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131047_0_2_1"/>
    <dbReference type="OMA" id="FHPAEPQ"/>
    <dbReference type="OrthoDB" id="509901at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01658">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Large subunit ribosomal protein L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005996">
        <property type="entry name" value="Ribosomal_uL30_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018038">
        <property type="entry name" value="Ribosomal_uL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01308">
        <property type="entry name" value="rpmD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00634">
        <property type="entry name" value="RIBOSOMAL_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8 10" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="9">
        <location>
            <begin position="5"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS23105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="104" mass="11925" checksum="5C6E981F99D72483" modified="2011-10-19" version="1">MPYWRITLHRSAIGLPKRTKGVLAALGLHKRCQVVFKPVHPQFAGMIMKVKELVKVEEVDRPKTKRELQDERKPDPGFVVEKRGSEMRGALPWAREVGEGEVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0S298</accession>
    <name>G0S298_CHATD</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0016470</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S298"/>
    <dbReference type="STRING" id="759272.G0S298"/>
    <dbReference type="GeneID" id="18255685"/>
    <dbReference type="KEGG" id="cthr:CTHT_0016470"/>
    <dbReference type="eggNOG" id="ENOG502SGXN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_285441_0_0_1"/>
    <dbReference type="OMA" id="DTNCEAT"/>
    <dbReference type="OrthoDB" id="2362516at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409227" evidence="2">
        <location>
            <begin position="20"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="736"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="807"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="857"/>
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        </location>
    </feature>
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        <location>
            <begin position="935"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="990"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
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        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
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        <location>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        <location>
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        </location>
    </feature>
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            <begin position="821"/>
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        </location>
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        <location>
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        </location>
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        </location>
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        </location>
    </feature>
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        <location>
            <begin position="990"/>
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        </location>
    </feature>
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        <location>
            <begin position="1018"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1085" mass="112938" checksum="5177C3CE3B9DFFB5" modified="2011-10-19" version="1">MRTIILILHGLCLVAAAEAGPLGRWGWLKLRQDDSNDDLGGSNTGAVGSSSTLGELTVVVQNPPEPTTSSLLAASTLLKSISTETAGPTALHEEDEESSASPTPEPTLTPTERNSATEDTSPTKTAVEPAETTSVEETTSTERGTPRTSKADENEIPSVTKTPIENTSTAEPTTGKLESSVTESATEVISPTETTLREEPLSTETEFTTTTETTTEGEKPTSTETLSPIETVVETTTSTESTSTKGPATVETESPSVTKTTTETTTSTESTSTDGLTSPETETTLFSTDKLTSTETETPSVTETVTESTTSVGTITTEDITTATKTSTESTTATETIFTETTSTETTTTSADETTSLATETSATNTGTSTANDSSIATSETATETTLSLTETSTSETGTTTMLIVTTITATDAITVTASETETSTTTFDGSTVTESTPITLTPTDTPSITSTESSATESTSRTASTETEEEEIPIPTSEIPSASGITETAPTTPLELTLVDDPVTNIKTLDTSSIETSTVVFTPTGTPNPDVPTAITEIPPLTSTVPPSVFETNLQNARQYNVIFAGLTKQSACANEQVACVDGGIGRCSANGVFEITPCAAGTSCFALPMKTVDGVEVTCETVEKAREVLGEIPEGLLPDPTSTVTQEPSSAVEETTSTKIPDPSETDTQMITEVPGETPVTTTQAEEPTGPSFVTIIFPGETGSEVLTMTEDPAPEVPTPIPEAPTLTAIPEETTNSPEVTQVPSPSDATPTSATSEPEPTEDFEVILTTTITSTTTVQPEPITKTVIIDVSTGVETITLTIEPDPVETGIPEDDTPEDVTSATPTTTPYTEPITKTIVIDVSTGVETVTLTIEPDPVETGAPDDGSLEEVISETPTPTPAEPTPVPENPTPVIGSPEQSTSQDMPTLSTTDLPFFIPFPTPTTFITIIITTTSSSSVSPPPAEDNTSVDVPTSIEDTPLTTTTTTTDGPSLPSISIPDWMSSLFSDLIPPTTSSSSSEDTLSKTADPTLVPPQPTATGDTSLPTSTETPKNEVTVRPSPTSLVVLPLPDTVTDTVTVTQTVKETETVTSVVTETVTIQARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3K9</accession>
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        <submittedName>
            <fullName evidence="4">Transferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0021630</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006692569.1"/>
    </dbReference>
    <dbReference type="ESTHER" id="chatd-g0s3k9">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="18256201"/>
    <dbReference type="KEGG" id="cthr:CTHT_0021630"/>
    <dbReference type="eggNOG" id="KOG4389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_261685_0_0_1"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="entry name" value="dinb family like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018531">
        <property type="entry name" value="DUF1993"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09351">
        <property type="entry name" value="DUF1993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="DinB/YfiT-like putative metalloenzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Erythromycin biosynthesis protein CIII-like C-terminal" evidence="3">
        <location>
            <begin position="256"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="526"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1063"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1074"/>
            <end position="1091"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS20336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1298" mass="142547" checksum="DCE393B1F1E978F6" modified="2011-10-19" version="1">MTKLLLATNTEFGQANVFLAVCHALQQLDPDIELHITSFAPLAKHIENASNFSIRTARQTHGPEINPRPWIFHPLHGTTMVQALWNINGNSIPPGLVARPGFSTCRKIMATGMTVLLPWKPEEFVETYKELEGVVKEVGADLVVVDCLFSHGLTVCQKLGVKYLVLSPNTLKEFAAFKQPWAAVVWKYPTMCSGIPFPVPWYLISLNVLYFTLQMVYAVLDTRTRALKAHVKKILGFSVGLGSKIHALLGKELDDDRVRIIDWIKPQPIAVLQTGAVVVSVNHGGANSYNDAIISGVPQVTLPTWLDCYDFANRVEYLGIGRWGSRTAAPSCASDELGPVLLDVVLGERAESYRRKAQEIAALCAKTPGSFVAACAILGEVGEQKDSFLAQRHGADRIRGRVRARNAAKASRDMRFPDIEEGIRVVPTTMALLKWLTTLTFASSLALGSPAARQETTDIADEWVSELIANLTEVDSSLKRRGLLGCSYNNRNLVVDLGYAKYRAHTMPLRVSTPGKGKRSFTIHENSAQVLTLESIRYAAPPTGNKRWQPPFPPAYQGSTPIDASQFGAVCPQFMPSIPGSQPIPGGDEDCLFLNVYAPPNARNLPVLVYIHEGGYGFGDGTRDLSDFINANEKGVIGVTIQYRLGAFGWLSSAEVKQKGVVNAGMLDQAFALAWIKTHICKFGGDPTKITISGESASGGSVMYHTMAVGGNLGTLLFNQGIAASPYLPFQYKYDDPEPTSKYYAFSAAAGCPSSGNVFNCLVSKDSETLKLASFNVTQSSTYGYWGFWPVTDNVYIQKRPSQQLPSKKVNGKKLLVGHNANEGGLFVPPSITTESDLIFWLQQQFPNLSTAQLNTILAANPNSANTDPSGPHFETNGLTGPTAVEVAQDANGQQQRGNNIYAEQVFVCPAYWMADSFVNPSKGQSSWLYQYSVPYAYHSSDISAYFGPPTTNQPADFILAFRRIWGNFVRTGNPSISAEIANGASSPNPSAPHPATNWPVWSNSNPQLLNLNTTGGTPYQEQLMWGPFVTQFQDALNDISLAPADVWEGGRRSRSMGMLHARSGASSDTFDGNCDREKESRSCNPEKEDVHEEDSEYKIAHNTKRHSDLRADQIPSLHKLRNPTMATVTRLLTVFRSGLATLDHILTVAEEHARSKGLDPDAEYPNARLIEDMLPLTFQVQNATKTVRVTLGRIEGKEYEAWEDNEKTISDLKARVQKARKLVEGTLARQEEVDKRAEEAVDLALGPNVLKTTAVESLFQHSIPNFFFHLNIAYAILRHKGVPIGKRDYILSFVQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3M9</accession>
    <name>G0S3M9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0021830</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692652.1">
        <property type="nucleotide sequence ID" value="XM_006692589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3M9"/>
    <dbReference type="GeneID" id="18256221"/>
    <dbReference type="KEGG" id="cthr:CTHT_0021830"/>
    <dbReference type="HOGENOM" id="CLU_2305770_0_0_1"/>
    <dbReference type="OMA" id="IWHEGRN"/>
    <dbReference type="OrthoDB" id="4585249at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS20356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="100" mass="11329" checksum="D1350E1374435985" modified="2011-10-19" version="1">MRPIATGGPTKRSSRTGSEDITRFRARPSGILSPNTISTLALGSMLAGSWYIWHEGRNYKVNKKVQKYEEKPLGKHRGNVNADYMKYDNWVDSRRASKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3U2</accession>
    <name>G0S3U2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0038860</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS22004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694300.1">
        <property type="nucleotide sequence ID" value="XM_006694237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3U2"/>
    <dbReference type="GeneID" id="18257924"/>
    <dbReference type="KEGG" id="cthr:CTHT_0038860"/>
    <dbReference type="HOGENOM" id="CLU_508977_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="2">
        <location>
            <begin position="25"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="427"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="495"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS22004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="535" mass="60931" checksum="C443A5E98FABD3DE" modified="2011-10-19" version="1">MRQTNNDRVVFIHGKKKRAPIVRLEQWMPWRPLIERLYLVEHKTQEEIVRFLNREEDFPVKPVWPRYQPLFQESMSDQLQIPLDKLQNYRWLAEIMEVLGDKYTASNIFMGLYEHNSKVNSQVGPNIEIGFAFSRTAQSLKQLAFAKNKVLPEIIRTLSHHHHYHQGNNSNEDDCPTWSHFQFDLNFAHVTDRESPGSNNALSQLYELFAEKIRPIGNDAQRHFMSFSPRTPNLLFDVPIYLAFVPAATRYDQAPPEYYMLNEPAPEESSNDEEVDEPNFLQLLEWFRNQQLVFSHRRCRASCLADCLTWCMKVLEHPSLVPQALETMITNPEAHIYIVLCTILQEWLRQHVQQERPQWVTTARTQLDLSPPQFLTVVVCMIMAEASQQSDTVASRHDLSCALLFRKASRSAGNLKSLPHKDLFNRSSKTGSTPCPKSTTPPPTTDSISSVALLAPFRKFIAQILTIDNLPPLDLHIPVYPLTLDMSGGGGDAFSPLPSSLESSPLANPQGSSSSGHLEQAEPGPSTAVRLAIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4D8</accession>
    <name>G0S4D8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0022460</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692712.1">
        <property type="nucleotide sequence ID" value="XM_006692649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4D8"/>
    <dbReference type="STRING" id="759272.G0S4D8"/>
    <dbReference type="GeneID" id="18256284"/>
    <dbReference type="KEGG" id="cthr:CTHT_0022460"/>
    <dbReference type="eggNOG" id="ENOG502SVPD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022039_0_0_1"/>
    <dbReference type="OMA" id="QDELQMP"/>
    <dbReference type="OrthoDB" id="5423493at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="390"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="608" mass="66768" checksum="F39E6D96BF26B908" modified="2011-10-19" version="1">MPRPRRSRVAPARPTVAAETVQQDLAPSDGKHDAASREPESVAVESQSSNLTEPHRARASMLKLDSDQTRALEESKQREDEAMARLDDLSSTSRPEQPESADNERESPARGRPRLTDVSGLDLEDLSLGNLDDSLDDSEDAIDDTRTGYRSTDTSTFSISMFKRGRPRQSSVAGRDDAPIRPSSRGQNTPSISTTLNFSNFRRRAREPSILSSVRKPMRHRSQSVTSQASRAASVLEDGDDSGPDGESTPVDKTRRQTRASQATEAANDDLHVCPSRKRKSLESHENYREKRPALDVSEPDEVPKPEEVLPSIEVDHEPVPASSPTRGRTRERERLSTPAQPPAAEDDPDMAPPMSSSASASNSPVAWPSLDALAHRNYTRKPPPRPETPELIDSSSELSSPPSLTHSPNYPTAAAKAAAARKKASVQPPAAKKLTTADLTSLLPQRRKKSAKRQESIDNDDPFDVDGSSDEERYVADPEDVSYVQARTSRRKKQPLSKSASNRKGKEKEVNGKADGGKKKAVRTYGSAKQQDKENEEVVAEEIVVGGAGNEDDEVESLPEEETTQMLTERIGEELAKAKKKFKEVDKWELSFEEVGPECSSPDPYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4G7</accession>
    <name>G0S4G7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Protein PBN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0022750</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase GPI14.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type III membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PIGX family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692741.1">
        <property type="nucleotide sequence ID" value="XM_006692678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4G7"/>
    <dbReference type="STRING" id="759272.G0S4G7"/>
    <dbReference type="GeneID" id="18256313"/>
    <dbReference type="KEGG" id="cthr:CTHT_0022750"/>
    <dbReference type="eggNOG" id="ENOG502QS8N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030047_0_0_1"/>
    <dbReference type="OMA" id="HELHIRW"/>
    <dbReference type="OrthoDB" id="5546453at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990529">
        <property type="term" value="C:glycosylphosphatidylinositol-mannosyltransferase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042322">
        <property type="entry name" value="Pbn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013233">
        <property type="entry name" value="PIG-X/PBN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28533">
        <property type="entry name" value="PROTEIN PBN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28533:SF1">
        <property type="entry name" value="PROTEIN PBN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08320">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00780">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 11" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="459"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS20445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="498" mass="55161" checksum="A7F52B1B1EA56D1D" modified="2011-10-19" version="1">MRERITFVQKLGDSLEPSELKVDSTTVSGPEVHAVREERLKFSVDELPSELQTLLSDFQGLDIKWVTDAYHETVSPLLSRLPPGFHVVFTPRRPDTSLDSLCSALVELFGDDIYCSNESFTALSKAQSTGVTTLQYYQPLRSLSHLTRRARSLLCRSDDTSCSNRLDSLTSASSLDIAYDSDANDFRVTATWPYQRQHIHATSREGHRTEVGILSTDKPKTLDPHEIGISGLITVLRENKKLSPVLFSFAARHRDAESSFSARFLSPTGLHPTLQLRLSSARPPRSPEEQECSLHAYLTLPRTIFPDRYQLSDPIFLASKNLSALRFATKPVDLEAPDYAVPQWGLALLLDLATPTESAAAGEFTAEIPLHLRYLAPASGGYRSIEIPYPAVFWACRDPAVADAPLGPFERSGLGYDALFADKPGIVFWHVEPKPAAGQGSRMVNTVRVPVLDMDKAGWVNLGTAAVIVFGFAWVVGRLAGVWLRRVAAEKERKKKTQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-06-24" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4T0</accession>
    <accession>G0ZGU6</accession>
    <name>NU192_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleoporin NUP192</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Nuclear pore protein NUP192</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">NUP192</name>
        <name type="ORF">CTHT_0023410</name>
    </gene>
    <organism>
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>SUBUNIT</scope>
        <source>
            <strain>DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2014" name="Proc. Natl. Acad. Sci. U.S.A." volume="111" first="2530" last="2535">
            <title>Evidence for an evolutionary relationship between the large adaptor nucleoporin Nup192 and karyopherins.</title>
            <authorList>
                <person name="Stuwe T."/>
                <person name="Lin D.H."/>
                <person name="Collins L.N."/>
                <person name="Hurt E."/>
                <person name="Hoelz A."/>
            </authorList>
            <dbReference type="PubMed" id="24505056"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.70 ANGSTROMS) OF 1-958</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. NUP192 is located to the NPC core at the nuclear membrane and is essential for de novo assembly of NPCs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 2">Component of the nuclear pore complex (NPC). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof (By similarity). Part of a tetrameric NUP192-NUP170-NIC96-NUP53 module.</text>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-4325187">
            <id>G0S4T0</id>
        </interactant>
        <interactant intactId="EBI-4325173">
            <id>G0S024</id>
            <label>NIC96</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>7</experiments>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-4325187">
            <id>G0S4T0</id>
        </interactant>
        <interactant intactId="EBI-16069276">
            <id>G0SAK3</id>
            <label>NUP145</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>3</experiments>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-4325187">
            <id>G0S4T0</id>
        </interactant>
        <interactant intactId="EBI-4325171">
            <id>G0S156</id>
            <label>NUP53</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>13</experiments>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
        <text evidence="1">Cytoplasmic and nucleoplasmic side of the nuclear pore complex in the nuclear envelope (symmetric distribution).</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NUP186/NUP192/NUP205 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JF276288">
        <property type="protein sequence ID" value="AEL00684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692805.1">
        <property type="nucleotide sequence ID" value="XM_006692742.1"/>
    </dbReference>
    <dbReference type="PDB" id="4KNH">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="A/B=1-958"/>
    </dbReference>
    <dbReference type="PDB" id="5CWV">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.15 A"/>
        <property type="chains" value="A/B=1397-1756"/>
    </dbReference>
    <dbReference type="PDB" id="5HB4">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="B=151-166, B=185-1756"/>
    </dbReference>
    <dbReference type="PDB" id="7MVT">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.60 A"/>
        <property type="chains" value="A=185-1756"/>
    </dbReference>
    <dbReference type="PDB" id="7MVU">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.77 A"/>
        <property type="chains" value="A=1-1756"/>
    </dbReference>
    <dbReference type="PDB" id="7MVV">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.22 A"/>
        <property type="chains" value="A=1-1756"/>
    </dbReference>
    <dbReference type="PDBsum" id="4KNH"/>
    <dbReference type="PDBsum" id="5CWV"/>
    <dbReference type="PDBsum" id="5HB4"/>
    <dbReference type="PDBsum" id="7MVT"/>
    <dbReference type="PDBsum" id="7MVU"/>
    <dbReference type="PDBsum" id="7MVV"/>
    <dbReference type="AlphaFoldDB" id="G0S4T0"/>
    <dbReference type="EMDB" id="EMD-24056"/>
    <dbReference type="EMDB" id="EMD-24057"/>
    <dbReference type="SMR" id="G0S4T0"/>
    <dbReference type="DIP" id="DIP-61834N"/>
    <dbReference type="IntAct" id="G0S4T0">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0S4T0"/>
    <dbReference type="TCDB" id="1.I.1.1.2">
        <property type="family name" value="the nuclear pore complex (npc) family"/>
    </dbReference>
    <dbReference type="GeneID" id="18256379"/>
    <dbReference type="KEGG" id="cthr:CTHT_0023410"/>
    <dbReference type="eggNOG" id="KOG1835">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002778_0_0_1"/>
    <dbReference type="OMA" id="WSQMFAE"/>
    <dbReference type="OrthoDB" id="2019644at2759"/>
    <dbReference type="EvolutionaryTrace" id="G0S4T0"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021827">
        <property type="entry name" value="Nup186/Nup192/Nup205"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11894">
        <property type="entry name" value="Nup192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0509">mRNA transport</keyword>
    <keyword id="KW-0906">Nuclear pore complex</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000433168" description="Nucleoporin NUP192">
        <location>
            <begin position="1"/>
            <end position="1756"/>
        </location>
    </feature>
    <feature type="helix" evidence="5">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="helix" evidence="5">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="helix" evidence="5">
        <location>
            <begin position="39"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="helix" evidence="5">
        <location>
            <begin position="53"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="64"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="71"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="helix" evidence="5">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="helix" evidence="5">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="helix" evidence="5">
        <location>
            <begin position="109"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="helix" evidence="5">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="strand" evidence="8">
        <location>
            <begin position="146"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="helix" evidence="5">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="helix" evidence="5">
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4X5</accession>
    <name>G0S4X5_CHATD</name>
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        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
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        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000003">
        <property type="entry name" value="Brefeldin A-inhibited guanine nucleotide-exchange protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.20:FF:000002">
        <property type="entry name" value="Brefeldin A-inhibited guanine nucleotide-exchange protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015403">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046455">
        <property type="entry name" value="Sec7/BIG1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF375">
        <property type="entry name" value="LD29171P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20252">
        <property type="entry name" value="BIG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09324">
        <property type="entry name" value="Sec7-like_HDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SEC7" evidence="7">
        <location>
            <begin position="620"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="196"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="253"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="569"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1019"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1306"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1550"/>
            <end position="1600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1829"/>
            <end position="1861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="207"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="579"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1314"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1557"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1571"/>
            <end position="1593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS21346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1861" mass="208803" checksum="2D2DB89417F0E4E3" modified="2011-10-19" version="1">MSSLKFVVSSLDIIAAHAGRNKQLAELAEKALSAIKENDQQLPDPEILFAPLQLATKAGTIPLTTTALDCIGKLISYSYFSAPASSALSQDGAEQTPLIERAIDTICDCFQGETTLVEIQLQIVKSLLAAVLNDKIIVHGAGLLKAVRQVYNIFLLSRNTANQQVAQGTLTQMVGTVFERVKTRLHMKEARASLGRLKQSRSSLAVDRTEDQDSQAEKLDSEEGTEGTGQAAQTDGAEDEGGKLTLKDLEHRKSFDDSHMGDGPTMVSQVKPIRPSGRSVSEQSLSESSPEESSEALDAEDEAYIRDAYLVFRSFCNLSTKVLTPDQLYDLRGQAMRSKLISLHIIHTLLNNHIIVFTSPLCTIRNTKNGQSTHFLQAIKYYLCLSIIRNGASSVDRVFEICCEIFWLMLKYMRAPFKNEIAVFLNEIYLALLARKNAPLSQKLTFVGILKRLCEDPRALVELYLNYDCDRNVDNIFQTIVEDLSRFATATIPVTPAQELQYQEHHPKAIAAGEWQIKTVLPPPLSVALIATHHDADGEIPKEYIMKRVALDALVDTLRSLLHWSQPGRPEANGAIVNSDRRASSDDARYSIDPSLSEAASRMETPLAPSTPVIDDDPDQLEKEKARKTALANAIKAFNFKPKHGIKQLIKEGFIPSDKPEDIARFLLHEERLDKAQIGEYLGEGDQKNVEIMHAFVDMMDFSKKRFVDALREFLQAFRLPGEAQKIDRFMLKFANRYITNNPNAFANADTPYVLAYSVIMLNTDLHSPQVQKRMTKEDFIKNNRGINDNADLPDEYLISIYEDIQNNEIVLKSERQAAAAAGTLPQTTGLAAGLGQALSNVGRDLQREAYVQQSEEISMRSEQLFRDLYRSQRKSAAKGIVKFIPATSFKHVGSMFDVTWMSFFSTLSSLTQNTHNLEINKLCFEGMKLGTKIACLFDLSTPREAFISALKNTANLNNPREMQAKNVEALKVILDLAQTEGNYLKESWKDVLLCISQLDRLQLISGGVDESVVPDVSKARFMPPPQRTETTDRRKSTSSVRKGRPRAHTGPQGVSLEIALESRSDEVIKSVDRIFTNTANLSREAIIHFARALTEVSWDEIKVSGSNDSPRTYSLQKIVEISYYNMSRVRFEWSHIWDVLGEHFNRVGCHANTAIVFFALDSLRQLSMRFLEIEELAGFKFQKDFLKPFEHVMSNSTNVAVKDMILRCLIQMIQARGENIRSGWRTIFGVFTVAAREPYESIVNLAYENVLQVYRSRFGVVISQGAFTDLIVCLTEFSKNMRFQKKSLQAMETLKSIIPTMLKTPECPLSQKAPGTSSQGETNLKSPSQQSRTSVEEGFWFPVLFAFHDVLMTGEDLEVRSNALNYFFETLLRYGGDWPSEFWDILWRQQLYPIFMVLRSRPEMTNAMNHEELSVWLSTTMIQALRNMITLFTHYFDALEYMLDRFLELLALCILQENDTIARIGSNCLQQLILQNVYKFTPEHWSKIVGAFCELFERTTAYQLFTATTINSTASLAPPSSGLELGGPLSPTTEATLPVDQKSLKINGAELGDSASPESNAADSEASQNSQSISATTPSSSTSQSQYTPQPQLEEFKPNNPLQQQPVVVTAARRRFFNRIISRCVLQLLMIETVNELFSNDSVYTQIPSSELLRLMALLKKSFLFAKRFNADKDLRMRLWREGFMKQPPNLLKQESGSAATYVSILFRMFADTSPERQESKADVEAALVPLCQDIIRGYLALDEESQHRNIMAWRPVVVDVLEGYAAFPREAFSSHINNFYPLCVELLNKDLGLELRTALLLVLRRVGEVGLGIESMGAATAEQQRKRAGSVLSIHHGPRPSPSMESIGDDPSSRVMGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4Y7</accession>
    <name>G0S4Y7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0032130</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693654.1">
        <property type="nucleotide sequence ID" value="XM_006693591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4Y7"/>
    <dbReference type="GeneID" id="18257251"/>
    <dbReference type="KEGG" id="cthr:CTHT_0032130"/>
    <dbReference type="eggNOG" id="ENOG502RMYU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2321983_0_0_1"/>
    <dbReference type="OrthoDB" id="10380181at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="99" mass="10908" checksum="14E7059B85D1DD8A" modified="2011-10-19" version="1">MLRANITKINRSSLQTLGARPLTRQPPINHVRTVMYKHDSPDHTTSTLVMTPKTWGMIGGLLAVAGGYGYMMGKPYKVIGSEHSPASIQEKTSQNMKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0S548</accession>
    <name>G0S548_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0024070</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692869.1">
        <property type="nucleotide sequence ID" value="XM_006692806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S548"/>
    <dbReference type="STRING" id="759272.G0S548"/>
    <dbReference type="GeneID" id="18256445"/>
    <dbReference type="KEGG" id="cthr:CTHT_0024070"/>
    <dbReference type="eggNOG" id="KOG3035">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051989_0_0_1"/>
    <dbReference type="OMA" id="VPIDRYK"/>
    <dbReference type="OrthoDB" id="671439at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01838">
        <property type="entry name" value="Isoamyl_acetate_hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045136">
        <property type="entry name" value="Iah1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209:SF19">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="272" mass="30024" checksum="1FCD0FC56C95EF89" modified="2011-10-19" version="1">MAVSYPQIVLFGDSLFQAAADLNDGFCFQAAIQAQVVRRFDVINRGLSGYNTSNALSVLPKIFSPPGPGVPRIAYLFILLGANDAAVPLPTNHQHVPLDKYKANLKRIITHPIFAAHKPKIFLITPPPLDQIRITELDKANGHPAATRQTKISAQYSQAVRDIAAENPNVTLIDLYKALMDTAIAKTPGFDPKKGPALGDPESGVRGYLERLLPDGLHLSAEAYRIFYDLVKPHLGSEWAGTRDEERAAYVLPDWRVAPWLEEDEYLKTFNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5J2</accession>
    <name>G0S5J2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0033150</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693753.1">
        <property type="nucleotide sequence ID" value="XM_006693690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5J2"/>
    <dbReference type="STRING" id="759272.G0S5J2"/>
    <dbReference type="GeneID" id="18257353"/>
    <dbReference type="KEGG" id="cthr:CTHT_0033150"/>
    <dbReference type="eggNOG" id="ENOG502QR1M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004517_0_0_1"/>
    <dbReference type="OMA" id="HANPQMP"/>
    <dbReference type="OrthoDB" id="5373550at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14723">
        <property type="entry name" value="ZIP_Ppr1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Positive regulator of purine utilization"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF1">
        <property type="entry name" value="PYRIMIDINE PATHWAY REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="87"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="163"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="244"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="790"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="892"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="790"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="803"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="814"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="903"/>
            <end position="973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS21457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1076" mass="117352" checksum="E9FE8E91A9ECD2C5" modified="2011-10-19" version="1">MPVPAHCPPSPDLHPSKRARQSPPDKESPTSLPSGGTASPTNDQLHDGPLSLELAHGSAIGAAPGSGRSASTAAKIGQSSNFRNVSACNRCRLRKNRCDQKLPSCASCEKASVACVGYDPITKREIPRSYIFYLEKRVEQLEGILAANHIPFPPADDLDYCSKASSNGPPGNLRPPVDPGNAARPEGPDTVTCARAAEGSGGDGSNKLQRISSKPGPASSDNRYLGSTSGISFARVVFAAVQSSVSDQKSNSEKGGIRPSRPANSIGGHGAGTAGQTTSMRDSFFGLHTKPTSHPAHFPNKALGQKLVRLYFEHANPQIPVLHRVDFMNMFERAYLEEGRVRGPRELYFLNMVFAIGAGILVGDPKGEPQGAEPSDSSSGSRQYQPEAYHASAIVHLEACLGSGGLEDLQAVLLLANFALLRPVPPGLWYIIGVAVRLAVDLGLHYEDPKELENGQWESSALQKPTFVREKGRREYMRDMRRRLWWCTYSLDRLVSVCVGRPFGISDHFITTEFPSLLDDEYITHDGIIEPPSERRLPSYKLVAQHYFRLRLLQSEILQVLHYRQVLSARAGGQNYQNLYMPTLPSAFLSKFDSFRSWRIDIDRRLWEWKNTAPRKEDTGVSFSTEFLELNYWQAIIMLYRQSLSTPTVFEGEYDTSKEVNNPTMYNVEPCEDEDRVYLKIAEAGQKILRLYRQLHLQGLVNHAYLTTHHLFVAGISYLYAIWHSPIVRSRLTMDEVDFTVLAATSVFTDFIDKCPPAEACRDAFDRTVKATLKMVNASGGFGQQYRSGHCNTAGSDSQHTFENARQEWHPKADNTSSAGSKLSHSSNKRPRPHHSLVDKMPAVTSSDAYSNASSCFISSFSSKLGAGSYLLAGPPAGPSVIKTEPGAYHSSVVRNFPRPPRSTASSTDNPTTPETSIEQSPMITSPSVSTVTGIQQQQAINSPMSGGATPTNNDFHSPRLSHQQPPMQQQFSPAPAGTPTRGAMSLSELQGLEFLQSLNNAGSVNSGANSSSGANNNNGLSPSGLMDGIDFTGLTAEAQMDLGFGLAWEGMHHDYSEGQSLDLFDGFFFGGGGTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5R9</accession>
    <name>G0S5R9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0033390</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693777.1">
        <property type="nucleotide sequence ID" value="XM_006693714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5R9"/>
    <dbReference type="GeneID" id="18257377"/>
    <dbReference type="KEGG" id="cthr:CTHT_0033390"/>
    <dbReference type="eggNOG" id="ENOG502S7KY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018356_0_0_1"/>
    <dbReference type="OMA" id="PAEEWMG"/>
    <dbReference type="OrthoDB" id="2504266at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046784">
        <property type="entry name" value="Eap1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20566">
        <property type="entry name" value="Eap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="715"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="737"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="818"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="885" mass="96300" checksum="6AC83F758548A087" modified="2011-10-19" version="1">MALRYSADFLLFLRQSPLCVKPPNLPPPEEWMGPPPETIRNQQKSANDRLKSGENASSLNHENRRPPHDRNGSRNTSNPDDIILGPPRTSFASATSARNSRSGDGEKGFRDSDRQDRGDRFNFRSRNNDSENTNDRFSREGRDNRTNNGFRRRGDQDDGEGWSTVKPRKSFGHEGAEGFHGRMSGGGAGSTGADRFEVREDRRTRDRDQDGSDRRNRNYENRSRDQDGDEVDGARRNGPGRSRTEGSWRDSANRNNSSSTNNAPMSNRERIEKAKSWRDRDPDDRPHDRYGDRSERNYERRWDRDRQNRVENEPEWLDEPAEGKPSHAPTEEDFKKFMEAMKAKAGGPTRSEEKPNVTSDKPAADTAAEPEQKVAAAPPVDTGPDKFFATYGNVTLDVVAGGAGESKDSAKPKTAKSSRFMAFLAPQEDRTKPELPTPAAGGEKSSQQSDAEREAFAALIQKLQRSGLSSGIQPSSSVQQSAPPQTQPSINNYPEPPPFPEMQRGIVASPDSYPQYANNERHDDPRVRTSQHSIHDIISPRPMGPTVHPPPPVTRPEQALQELLAQRHQLPAQTNIRAAQNATAVNSNTEYLMRLMQSHRDTSEPPRTEQPFVRMPQPTKQVSLANLPDRDPDYQREHTASQRQPLPRQGGPPGFLDESQFRQNDVDGRSGPQPTQILQRPPPPPGLDQMHMFHHMGGVNPGIGPAPQGGSMPGPQRPMIPPPGLMNNGPRNVPMPGMYPPNFPPPHHGPGNFPPGPPPLPHAGGPPPPPEGLVGPGPPPPGPPRSMQPPPGFFGGPPPPGFMPPPNMGAGAGGFQGPPGPGPDGHPPPPPPNAGGPPGPGGLPGFGGMPGPYDRMGAAAAVAAAAAMDRRGMLPPPGAMGGYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5S9</accession>
    <name>G0S5S9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0033490</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693787.1">
        <property type="nucleotide sequence ID" value="XM_006693724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5S9"/>
    <dbReference type="STRING" id="759272.G0S5S9"/>
    <dbReference type="GeneID" id="18257387"/>
    <dbReference type="KEGG" id="cthr:CTHT_0033490"/>
    <dbReference type="eggNOG" id="KOG1812">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008160_0_0_1"/>
    <dbReference type="OMA" id="HEVANCD"/>
    <dbReference type="OrthoDB" id="9977870at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="593"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="526"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="673"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="866" mass="96858" checksum="103600CCCDCE4C4E" modified="2011-10-19" version="1">MAEVGREQGGPSTARRKRPSSKARSQVANDWPEPGETRSRASRRSKRHVPADIDVDVVETPTSSTSSSSDEDDDVDIKTSSRTKLKRRRVRQRRREPASSTSTTSDSDTSSTPPRTPLKSPRAAKRSSSSRVPNASDSAPNMSRHHHPTYVGVIEEAEDDDEVAQTLPSRPASRQTVSRRDVSPRSVHRYRSTPESRRSPRTPVSDSDDDATDATSDSDDRIHLFRRKQLPAVPSAPPPPNMHNSLKERLGGRDPDETAYEDDADAISRYAPSTRHRSRSRPPENRRDLDEYRRPRDITVSSPPSVDETRSRSRSRRPSKRHYESDAYVSRPSSSQKRLHAASSQSLSSEAKRSTLFGGAAASSVHPARHDKMLDRLTTCVSCGNEATPDAGEEVVPGQLDIRRKPFNYTSAYESRAPSPTRDYRSDFVPMQSPTLRVRPTSYDDEVFWRRMHDRQRDEHLARRMHSFDVFGHHESHVDRAGDEDYEYEEQRGRRRRPEKSRSYPVAFLDDDYRLRRAATVVAPSSQQPAVPEVPAPARSAFEPPSRPALERAASAFDYPTTTPRSRRMRQASPEGYGEYTTNHYTPERRCWQSPEKWQGFSSERRARSHDRRHTYPVESRAASPDGWQQLPTRFPSPERIDTASEPRRRAHSLERPRASSLERRLADRFNPETRAAPAAATIPTSPAGPVGHHLGTLGPLGPLSPAMFPPHPPPLTAPGAPAMPMVSMPPPAMHGVPHPPAMLRHPMEEDMYHPGMHGALPSHPGPADWYAPASMPHTGMPSIPHPHAPDMLTGPTTATMDPLAVVSPRTPNFKRRLREHHKMEPPRSSVLAGLAGPGRGMHRVYEWVNYVEPGPPDAEPPATVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5T6</accession>
    <name>G0S5T6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF300-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0033560</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693794.1">
        <property type="nucleotide sequence ID" value="XM_006693731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5T6"/>
    <dbReference type="STRING" id="759272.G0S5T6"/>
    <dbReference type="GeneID" id="18257394"/>
    <dbReference type="KEGG" id="cthr:CTHT_0033560"/>
    <dbReference type="eggNOG" id="KOG2641">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012923_4_0_1"/>
    <dbReference type="OMA" id="AFAIAHW"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="368"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="448"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="448"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS21498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="61683" checksum="5D5E7608493D26ED" modified="2011-10-19" version="1">MTGGTGQKFEAATTVVAGVASLIATLLSIVSIWLQLKNYRKPLLQRYVVRILLMVPIYSIASWTSMVSRLAADFLDPVRDIYEAFTIYTFFQLLINYLNGERALIIMTHGREPVHHLWPLNHVLPRVDISDPYTFLAIKRGILQYAWLKPILALATIIMKATDTYQEGYIGLKSGYFWSGIIYNISVTISLYSLGLFWVCMNNDLKPFRPIPKFLCVKLIIFASYWQGFFLSILVWLGAIPDQVEGYTPDNLAAAIQDFLICIEMPAFAIAHWYAFSWHDFADNRIASARMPVYYAARDAFGIRDLIQDSKETFKGDKYGYRIFDSGDKIMAHELSRSRLARIKAGMRYERGGKGKYWLPRPEEIKETTPLLGGNGGPSRRNGSISPHTNSFEEPVLDPEEEQLYESARKLEYGDWNYPVITASEPASKRYMSPHPSLYQHTLTGSVYNRSSSSSAHSVRSDDPLGRQKKKVQEGPQAGVTDKKGKKKAISQTSSPNPSYALGKNPLEIAYGPTVGLKILEPTIGRLPFQFMTDQVKKDSKYGDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0S5V5</accession>
    <name>G0S5V5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-2-hydroxyglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="7">1.1.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0033760</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2</text>
            <dbReference type="Rhea" id="RHEA:21252"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:16782"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.1.99.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the L2HGDH family.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.2" evidence="7"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693813.1">
        <property type="nucleotide sequence ID" value="XM_006693750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S5V5"/>
    <dbReference type="STRING" id="759272.G0S5V5"/>
    <dbReference type="GeneID" id="18257414"/>
    <dbReference type="KEGG" id="cthr:CTHT_0033760"/>
    <dbReference type="eggNOG" id="KOG2665">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024775_1_0_1"/>
    <dbReference type="OMA" id="GVHFTRM"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047545">
        <property type="term" value="F:(S)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104:SF4">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="10">
        <location>
            <begin position="69"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS21517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="446" mass="48545" checksum="03AB3D4B57AE1408" modified="2011-10-19" version="1">MYTSFCLAITSEKVIRSIIQSRPLPGFRSRPHTLLSSLSTHHQQSHSRRLSSHTVSVSQLRADHDFTHAVIGGGVVGLAIAQELARRSSRPGSTLLLEQHTAVGTETSSRNSEVIHAGIYYGATSLKTELCISGKQLLYSLCEKEGIPHRRTGKWIVAQTDAQREALQRVYDFCTQEIHVPMRWVGAEEAARREPAVRAEKGVLESPTTGIIDSHSLMMCLLGKFEDAGGTLALGSRVEAITPLGGDGSQGWKLTVRDTTGSGELSTITADTLINAAGLGAVAVHNMIVPPDRRRKMFYAKGNYFSYGGSSPKVSTLIYPAPEPGHAGLGTHLTLDIGGRIKFGPDVEWVDSPEDLSVNESRLSETIREVKKYLPALDETLLRPDYAGIRPKLGRQGAVVSGKGFIDFVIQREEGYHGWINLLGIESPGLTSSLAIAEKVRKLLYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0S603</accession>
    <name>G0S603_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Pheromone receptor 1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0025550</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693015.1">
        <property type="nucleotide sequence ID" value="XM_006692952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S603"/>
    <dbReference type="STRING" id="759272.G0S603"/>
    <dbReference type="GeneID" id="18256593"/>
    <dbReference type="KEGG" id="cthr:CTHT_0025550"/>
    <dbReference type="eggNOG" id="ENOG502S44N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1256809_0_0_1"/>
    <dbReference type="OrthoDB" id="2874149at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004932">
        <property type="term" value="F:mating-type factor pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001499">
        <property type="entry name" value="GPCR_STE3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097:SF1">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02076">
        <property type="entry name" value="STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS20719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="258" mass="29282" checksum="7488D37947F70DA8" modified="2011-10-19" version="1">MSSPTNNTVLPDKCAQYDFTTTPAERVGPPPPYTSPSLQANLAFRVTLGAISLFITWVPARLLWRTGEFAGTILCVMLIINNTTTLVNTLIWRDNKVAEWWTGYGLCDLQVYTQFAFHAVFNISLFEIMRGLEAKVSLNRSIAPIRAEHRRQRIISALIIFTFPVLEITLNYFVLTRRYDIKTLVGCNTIYFSSWIYLIFYILPIPVFMVGASFRAGDNVAQACQQRVRIKLYFMTLIVIVVATPITLAFLISYLLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0S618</accession>
    <name>G0S618_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Store-operated calcium entry-associated regulatory factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Transmembrane protein 66</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CTHT_0025700</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SARAF family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693030.1">
        <property type="nucleotide sequence ID" value="XM_006692967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S618"/>
    <dbReference type="STRING" id="759272.G0S618"/>
    <dbReference type="GeneID" id="18256608"/>
    <dbReference type="KEGG" id="cthr:CTHT_0025700"/>
    <dbReference type="eggNOG" id="ENOG502QT6Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046802_1_0_1"/>
    <dbReference type="OMA" id="WILKGSC"/>
    <dbReference type="OrthoDB" id="20303at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006816">
        <property type="term" value="P:calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001256">
        <property type="term" value="P:regulation of store-operated calcium entry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009567">
        <property type="entry name" value="SARAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929:SF0">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06682">
        <property type="entry name" value="SARAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0732">Signal</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408867" description="Store-operated calcium entry-associated regulatory factor" evidence="16">
        <location>
            <begin position="33"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="196"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="274"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGS20734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="319" mass="34038" checksum="65CD24723044741A" modified="2011-10-19" version="1">MRLTKIPSPPTSLPTLFLALLTALSFPSRAFAVRGRPKDAILLSEVQSLTLYANRLTTARRTKPIPQLKCVSPQSLCDIVVPHLKTMRCVNQGHSYTSEDIEWACTATLPTTVRLDRTEVICEGYESPDDPYVLRGSCGVEYTVQLTAEGERRYPGLVGIGRGNGDDWAGWLFAVVFVAVLVWIVYGACTQTGRNAGGTGGFNTNRRGGWGPGGGGGGNDAPWDDPPPPYPGTKPSSSTEQQGWRPGFWSGAAAGAAAGYMAGRNSRNREREYGYGTRWGEGSGWTSGSGWGGGRSSSSSSAGSTSRHETTGYGSTSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>G0S694</accession>
    <name>G0S694_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0025940</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693054.1">
        <property type="nucleotide sequence ID" value="XM_006692991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S694"/>
    <dbReference type="GeneID" id="18256632"/>
    <dbReference type="KEGG" id="cthr:CTHT_0025940"/>
    <dbReference type="HOGENOM" id="CLU_2399466_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="93" mass="10496" checksum="FF6E1DB636E44DE4" modified="2011-10-19" version="1">MAPVYARIHRDYNALLRDSNTIQAISAARDEIRKFLDSADQHIEEIALRPPKRPSTPAPQLPDPMKLDTELDSTPANFSRVVAFCDFYNANPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6D5</accession>
    <name>G0S6D5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0034530</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the WD repeat MDV1/CAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693886.1">
        <property type="nucleotide sequence ID" value="XM_006693823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6D5"/>
    <dbReference type="STRING" id="759272.G0S6D5"/>
    <dbReference type="GeneID" id="18257491"/>
    <dbReference type="KEGG" id="cthr:CTHT_0034530"/>
    <dbReference type="eggNOG" id="KOG4155">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012350_1_1_1"/>
    <dbReference type="OMA" id="ERLRYMD"/>
    <dbReference type="OrthoDB" id="496at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22881">
        <property type="entry name" value="Mdv1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000404">
        <property type="entry name" value="Mitochondrial division protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000881">
        <property type="entry name" value="Mitochondrial division protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="428"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="470"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="550"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="633"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="656"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="65"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="253"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="281"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS21590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="774" mass="84943" checksum="FD6BD278B02E3F74" modified="2011-10-19" version="1">MQDQDLTLPASLEAGGWDPGPNRRSHLQRCENKSRKSLAASPSDAVADAHNPESRCLAHRLRSITANGKPGRPAHQPAIPSVPEPTSLGPLKGGAHTPPTDPAHTSPVPRAAHTHAGLLEGRARAPAAPPPGGQLWLAASATRGLEAFGRKVTSTASQLISTTRDPTSNRQYKSAMSEVTKHLRKPDVQRSIFAAARTTPTDLVRSRLSTKEIQSRALSYLPDELLKNIPESNHQYSLFQGFQASFPEFTEEGKKHMRRVSRGRKLLDDGPSPPEGTPEALQKLRKDKAALAHQLELLSIRKNMASCEIREIDAKIENLKGMRQIVLDRLANLEKDEALLEHEIVELENKIEEAQEMAAEAESVAMRTPTKSDEDGSSQTDSAPGFMSQSIYEKLPAVQNKRKPRSIRRKATAILHEHFKPGTSIRTMRAHHDIITALDFDAPFGLMVSAAMDDSVRVWDLNAGRCIGVLEGHTASVRALQVEDNILATGSMDATIRLWDLSKAHYDPQGSEFGKADEDDDDAAIAFENPDDQPVEPPPGSMADCPLYTLQAHLDEITALHFRGDVLVSGSADKTLRQWDLERGRCVQTLDVMWAAAQASALSATVDTWRHTSRPHDASADFVGALQVFESALACGTADGMVRLWDLRSGQVHRSLVGHTGPVTCLQFDDVHLVTGSLDRSIRIWDLRTGSIFDAYAYDHPITSMMFDARRIVCAAGEDVVKVYDKVEGRHWDCGAGVTDTEDGRTPAIVERVRIRDGYMIEGRRDGMVGVWTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6N4</accession>
    <name>G0S6N4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0035000</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693932.1">
        <property type="nucleotide sequence ID" value="XM_006693869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6N4"/>
    <dbReference type="GeneID" id="18257538"/>
    <dbReference type="KEGG" id="cthr:CTHT_0035000"/>
    <dbReference type="eggNOG" id="ENOG502RYK1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030504_0_0_1"/>
    <dbReference type="OMA" id="QVWRMLT"/>
    <dbReference type="OrthoDB" id="244495at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF27">
        <property type="entry name" value="PHO85 CYCLIN CLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS21636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="327" mass="37080" checksum="2949B38D20B275B5" modified="2011-10-19" version="1">MPGGVCAVLDYDVELMADYVAEMATRLVTPHTNTVNPAFRKFVCQILTSTRLPSTTILLGMNYLAKRINMMDAVGQKPNNEGQIWRMLTIALLLGSKFLDDNTFQNKSWSEVSGISVQELNTLEYEWLGAIGWSLYVHLDESKDYQAWLANWKAWKETRKRERQTNLTTSVESDSSRARAQYLQNTWYQMQVAEYKRYEAMKANEAAMAASYRRDQSRWASQTYSWSQPAPSLTPPDSGYGTPEYPNPTTLLKLDYVDASLYGSTATSRHYGNHQNPSYNAKSGAYYPYAYNFWQHPRMAGCPCAGCTPPQPVAYFDARVYGQAVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G0S788</accession>
    <name>G0S788_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative GTP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0027820</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693239.1">
        <property type="nucleotide sequence ID" value="XM_006693176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S788"/>
    <dbReference type="STRING" id="759272.G0S788"/>
    <dbReference type="GeneID" id="18256820"/>
    <dbReference type="KEGG" id="cthr:CTHT_0027820"/>
    <dbReference type="eggNOG" id="KOG1673">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_0_0_1"/>
    <dbReference type="OMA" id="DSKAHYH"/>
    <dbReference type="OrthoDB" id="6585768at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090068">
        <property type="term" value="P:positive regulation of cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04128">
        <property type="entry name" value="Spg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000330">
        <property type="entry name" value="Septum-promoting GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017231">
        <property type="entry name" value="Small_GTPase_Tem1/Spg1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS20943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="310" mass="34434" checksum="DC38D83B8B1E3FA4" modified="2011-10-19" version="1">MERDQLAAPAPSESAASDYRDHSLADAEVAPSSDCENNGFHDHHYSQSQHYDQDDAAESEPTARYNTPSGSGQQISRPPSGLSGERGAGYATDQGSRAGSNSASQEQQQQQSQQPPARNHVVIKVGMVGDAQIGKTSLMVKYVEGSWDEDYIQTLGVNFMEKTISIRNTEITFSIWDLGGQREFVNMLPLVCNDAVAILFMFDLTRKSTLNSIKEWYRQGRGFNKTAIPVLVGTKYDHFVNLSREEQEEISNQARRFAKAMRASLIFSSTSHSINVQKIFKIVLSKAFDLKCTIPEITNVGEPLLIYKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7G1</accession>
    <name>G0S7G1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Putative GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0028020</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endomembrane system</location>
            <topology evidence="11">Lipid-anchor</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the small GTPase superfamily. Rheb family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693259.1">
        <property type="nucleotide sequence ID" value="XM_006693196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7G1"/>
    <dbReference type="STRING" id="759272.G0S7G1"/>
    <dbReference type="GeneID" id="18256840"/>
    <dbReference type="KEGG" id="cthr:CTHT_0028020"/>
    <dbReference type="eggNOG" id="KOG0395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_9_8_1"/>
    <dbReference type="OMA" id="SARHNEN"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04137">
        <property type="entry name" value="RheB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000273">
        <property type="entry name" value="GTP-binding protein Rheb homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS20963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="232" mass="25551" checksum="3082BA0832A7AC4E" modified="2011-10-19" version="1">MSAPGQCANRRASWAKPQVGRLEPAGRPLPTADAKIDRRASRSGLAHPASSPLLRVPSNRKPTGKSSLAVRYVDGHFVESYYPTIESTFSKEIKYKGQEYATEIVDTAGQDEYSILNSKQVIGTHGYMLVYSVSSLQSFEMVQVIRDKILNHLGTDSVPIVIVGNKSDLRPEQRQVTPEQGKALADKYKCAWTEASARYNENVAKAFEMLIGEIEKSQNPTANSEGSKCIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7S1</accession>
    <name>G0S7S1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0028610</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693317.1">
        <property type="nucleotide sequence ID" value="XM_006693254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7S1"/>
    <dbReference type="STRING" id="759272.G0S7S1"/>
    <dbReference type="GeneID" id="18256899"/>
    <dbReference type="KEGG" id="cthr:CTHT_0028610"/>
    <dbReference type="eggNOG" id="KOG0234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006383_0_2_1"/>
    <dbReference type="OMA" id="VKTHVFH"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000031">
        <property type="entry name" value="6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF39">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE_FRUCTOSE-2,6-BISPHOSPHATASE YLR345W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="4">
        <location>
            <begin position="45"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="500"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS21021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="534" mass="60654" checksum="1AC62F278801DFE7" modified="2011-10-19" version="1">MDTLLTAEIAANSPRYRRRSSTFIDGIHDVSDDQGQMAPAQLYSTMSGRLFHSGRIAIIMVGLPARGKTLGVKTRVFHLGDYRRATVPGGKVPEDYFYPNASPASQMLRQKILKKCREDIYAWLNHENGQVAIYDAVNPTAAGRRALAKEFANHDVQTLFIESYVDDPEILKENARNVKISSPDFHGMDPDEAAKQYLKRIETKIPVFETMNEEELNYVKMINAGQSFFYNNVSFNYLSHRIVFYLTNLHIKSRRTFFARAGTTTDEDSYKADAPLSEEGRHYARKMAETLLRHREQERLASIANGGPDVPLRPLTVWTSTRLRTVQTAEPLKEMGFKVRQRSQMSQINPGVCEKLSERAIRALYPEEVEKHERDPYHHRYPRAESYHDLAVRLEPIILELEREQNDLLIIAHESVLRVLYAYLMHCSTMDIPKLKFPRDEIIEIIPAAYQNEAKRIHIPGLDPKTIPSSPEDIRIPVPSPSGQATPVPAMPNLPESAAANVEEEQAAPVQHPPEKIVNTAVKDMVSDKVTDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0S813</accession>
    <name>G0S813_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BOD1/SHG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0029000</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693356.1">
        <property type="nucleotide sequence ID" value="XM_006693293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S813"/>
    <dbReference type="STRING" id="759272.G0S813"/>
    <dbReference type="GeneID" id="18256938"/>
    <dbReference type="KEGG" id="cthr:CTHT_0029000"/>
    <dbReference type="eggNOG" id="KOG2217">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012822_0_0_1"/>
    <dbReference type="OrthoDB" id="5579731at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055264">
        <property type="entry name" value="BOD1/SHG1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28034:SF1">
        <property type="entry name" value="NUCLEOMORPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28034">
        <property type="entry name" value="SET1 COMPLEX COMPONENT SHG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05205">
        <property type="entry name" value="COMPASS-Shg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BOD1/SHG1" evidence="2">
        <location>
            <begin position="51"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="663"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS21060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="761" mass="86293" checksum="DCA3A859AA86DFB9" modified="2011-10-19" version="1">MSAAVDSPTTEANPVPIAGTTAPEATAPPRRKFKASDLPLPSATRSAIERLAHNFKKKGGYDAIRKQVWEKFEASDYEEQVTKAILEVAEQEIERNPEQLLTLERGKAAALIDGALDRSGVYQKAEEVISALIDTCAIESAIRELRRSEIGDEAAEEERIRGAKTDEEYAAETAARRAERERVRAELKAVEEEKRRLEREIKLKEEMRRREAERAAREERRRKEREEDEKRERERRERREKEREERDREREREREKEKDRERDRDKERDRDRSRDRDRNRNSDRDRDRARDRDRSRDRERDRDRERDRDRDRDYDRYREHRGYDSYRGTPRDRSVGRDRARDRDRDRERDRDKNRDRDRDREKEKNQESGRDARSKLSLEERAEEVKKRLTKEDDERLEQEALADLLRESKRLEKKQPELEVDETLVPPPKKPKPGSAIAPIQRPAPKLGTEPKKPAESKETADSKDKSSSSRSEKPDDSGKPTHGTGREKTIIAVGIFAPALPAESEADHAAEAAQGSGAGQEHAIGADRVCGLIAEMNAIMAGVTLLVIGEVVPVHALPAQTIGETGVGLGVVIPAIAAAHPVPGPIATIGLGLGYVIATVVEIATAAVIATAIVTANVVEARPPSRMNHEEKEAWKQAEVKKREQEAKAYLAAQKEAREKGLPVPGIDDRRTSDRDRSPDAKRRRDKDEADRYLPDRDRDRDRRDIVDYRGGDRYDGDLAAIEVFPLAAGEIPVGAGMTADGVAEVGAKPTATDDVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0S832</accession>
    <name>G0S832_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar protein 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0029200</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="11 12 13" key="2">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e56910" last="e56910">
            <title>Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation during pre-60S biogenesis.</title>
            <authorList>
                <person name="Lau B."/>
                <person name="Huang Z."/>
                <person name="Kellner N."/>
                <person name="Niu S."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
                <person name="Cheng J."/>
            </authorList>
            <dbReference type="PubMed" id="37129998"/>
            <dbReference type="DOI" id="10.15252/embr.202356910"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NOP16 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693375.1">
        <property type="nucleotide sequence ID" value="XM_006693312.1"/>
    </dbReference>
    <dbReference type="PDB" id="8I9P">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="CR=1-237"/>
    </dbReference>
    <dbReference type="PDB" id="8I9R">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="CR=1-237"/>
    </dbReference>
    <dbReference type="PDB" id="8I9T">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.60 A"/>
        <property type="chains" value="CR=1-237"/>
    </dbReference>
    <dbReference type="PDB" id="8I9V">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="CR=1-237"/>
    </dbReference>
    <dbReference type="PDB" id="8I9W">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="CR=1-237"/>
    </dbReference>
    <dbReference type="PDB" id="8I9X">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="CR=1-237"/>
    </dbReference>
    <dbReference type="PDB" id="8I9Y">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="CR=1-237"/>
    </dbReference>
    <dbReference type="PDB" id="8I9Z">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="CR=1-237"/>
    </dbReference>
    <dbReference type="PDB" id="8IA0">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="CR=1-237"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S832"/>
    <dbReference type="EMDB" id="EMD-35279"/>
    <dbReference type="EMDB" id="EMD-35281"/>
    <dbReference type="EMDB" id="EMD-35283"/>
    <dbReference type="EMDB" id="EMD-35285"/>
    <dbReference type="EMDB" id="EMD-35286"/>
    <dbReference type="EMDB" id="EMD-35287"/>
    <dbReference type="EMDB" id="EMD-35288"/>
    <dbReference type="EMDB" id="EMD-35289"/>
    <dbReference type="EMDB" id="EMD-35290"/>
    <dbReference type="SMR" id="G0S832"/>
    <dbReference type="STRING" id="759272.G0S832"/>
    <dbReference type="GeneID" id="18256958"/>
    <dbReference type="KEGG" id="cthr:CTHT_0029200"/>
    <dbReference type="eggNOG" id="KOG4771">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078857_0_0_1"/>
    <dbReference type="OMA" id="MQQTEAD"/>
    <dbReference type="OrthoDB" id="285729at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019002">
        <property type="entry name" value="Ribosome_biogenesis_Nop16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13243">
        <property type="entry name" value="HSPC111 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13243:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09420">
        <property type="entry name" value="Nop16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="11 12 13" id="KW-0002">3D-structure</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="105"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS21079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="8I9P"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="8I9R"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="8I9T"/>
        </source>
    </evidence>
    <sequence length="237" mass="26909" checksum="3C86C38C499C8440" modified="2011-10-19" version="1">MGRELQKRKRRSSRPTIRMPNRRKKALNPAGNNIIAKSWNKKETLSQNYTRFGLVAKLGKATGGTAPGNKALLKDLNDPLAIKSGDQGLIKVSEVKVERDEQGRIKRVVRDNNPLNDPLNDLDSDSESDAVPQQQQQEQPVLNNHIRQHDLELENVAADVDDESKPEVLRALEREATRPVEKTVRHQSEREREWLQRLVDKHGDDVAAMARDRKLNPYQQTASDIKRRLKKAGLLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8F5</accession>
    <name>G0S8F5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0029700</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693425.1">
        <property type="nucleotide sequence ID" value="XM_006693362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8F5"/>
    <dbReference type="GeneID" id="18257008"/>
    <dbReference type="KEGG" id="cthr:CTHT_0029700"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014245_1_0_1"/>
    <dbReference type="OMA" id="FYWLAKY"/>
    <dbReference type="OrthoDB" id="9439903at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF12">
        <property type="entry name" value="RFEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="188"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="356"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="366"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="481"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS21129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1023" mass="110466" checksum="F23E509AEFA16CE8" modified="2011-10-19" version="1">MEGLPNNAANAINTTTASYPASSTVSTHHPQLQQHHHHHQQQSSAAPPQTLPPLQPSNPVMQQPPYGSYPHTPRTPGTPNTPTSSGNMASYPPPPPQNAGRGATYPILGNNTYPQQPYPGASSTMLPQTTTAASHPQPIAPAPAPTSGRAPPVLRPMPAGGVMGTQPGMSSPYGQAPLMPQTSMLPEGEQPTHVVGTQGRRGILPSAPGRPAAPPAGSPAAKTQIPQKDADGKFPCPHCTKTYLHAKHLKRHLLRHTGDRPYMCVLCHDTFSRSDILKRHFIKCSVRRGNPTGASHLSHPQAHVKKNAAAQQKAMGTEGDVNHINGMGNMPADGMVHPFGLIPASDGMNNLANDQSQLSRSSSMNRLDDANRDRRNIPASVMPPATTRPGGFEQTYSSGEVANNMTANINPQLANYSMPQSQNGMPMFNQSGSTDWSQMFQGAHTAYTYANPPNIGQGQMQTVTLKPHEPNPGACAPRPVSTTSGDISTTADASTSSPLLDWGIPSSFPNPYQHLSAKILDFLRSSPAAATSPVSALLDSFFQPDDVQANLLGYTNFHAHLSILHVPTFRALEAHIGLVAAMCCVGACYANRISSANLREVMELLKAALESSSRMFASLLQNGSADPQYEWTLFGSNKTDLEELQAIMLTQILFTWHGTPEQRDKARKVFPLIASSARKAGLLSLVTNGTLHSTVHHPDFTLQSAAVTPFDWLSWVEQEKRIRTMYMIFTYDIALGLYFNIGPEFDPFEIRLPLPSDDAAWEARTAEDCAKALGLRGPEAVKLLNPDGTGRWNQPQLHMALKALLDPNIQIQPGSTNLFGKFIIIHALLSLMRKAWLEGGSAIINRSSTPIPTNNAWFAGAQGTASANNSGRATPVDPGSNLLDAQSFKTFQTALDKFKANWDYDMSVQFSPQAATAALNPNPHRYGFTRDGIHFYWLAMYLLKNMRAADLQAAPEQRFPYVFQLLKSAKQNVIADAYSRGEELGSVGAIDASYGASGDMILDMTQLFRPLSSFEPSSAVVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8L1</accession>
    <name>G0S8L1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0038470</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694267.1">
        <property type="nucleotide sequence ID" value="XM_006694204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8L1"/>
    <dbReference type="STRING" id="759272.G0S8L1"/>
    <dbReference type="GeneID" id="18257885"/>
    <dbReference type="KEGG" id="cthr:CTHT_0038470"/>
    <dbReference type="eggNOG" id="ENOG502SDXU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077728_0_1_1"/>
    <dbReference type="OMA" id="MPYSETG"/>
    <dbReference type="OrthoDB" id="41532at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="47"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="204" mass="22385" checksum="D2B72108A5590B91" modified="2011-10-19" version="1">MATNNTSSSNGNHPMTYLFSQPDHGHLVPYLAALHASCITQDQMVGPFLPPLTNEKLLTWWKERIAEANRGVRIIVLLLNPSSSADLKNGGKPAGTDLRGLGMVKLSESETGSFRGHIDAVLVDRRYRRQGGARALVAALEYEAVKRGRTLLLTNTETGSVAEEAFRKFGYIEIGKVPHFSRTLTPGVKKGGTFFYKEFQVVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0S905</accession>
    <name>G0S905_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ataxin-10 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0044090</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play a role in the regulation of cytokinesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ataxin-10 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694801.1">
        <property type="nucleotide sequence ID" value="XM_006694738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S905"/>
    <dbReference type="STRING" id="759272.G0S905"/>
    <dbReference type="GeneID" id="18258447"/>
    <dbReference type="KEGG" id="cthr:CTHT_0044090"/>
    <dbReference type="eggNOG" id="ENOG502SC2U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005559_0_0_1"/>
    <dbReference type="OMA" id="FIMHNEH"/>
    <dbReference type="OrthoDB" id="379794at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051374">
        <property type="entry name" value="Ataxin-10/CTR86_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019156">
        <property type="entry name" value="Ataxin-10_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255:SF0">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09759">
        <property type="entry name" value="Atx10homo_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ataxin-10" evidence="7">
        <location>
            <begin position="808"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="738"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="866"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="934"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="943"/>
            <end position="953"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS19916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="988" mass="110383" checksum="D51761134346CCA0" modified="2011-10-19" version="1">MSSTTAAEPAQPAAPAAPAAQTTTATATTPAPPSTTPASSSTQDIAAPQSSKDAQQKETSQVIRRPLSIEELCFTSAMSCFEGWLKLDPAIGPRTMHYVTKFISRTLEKTHNLKDVRENLSKSVEVWLWLTKDFAAAIPSLTTRSIGPLSSLNDPERSVTPQESTTLIIKNYSSLKEDLQLLIKLMHIARNLLVVPEPEIPQDLCAATQFDQMLYQTIILCINVTSKAYDGDVLEDSARSKLSEITELYKKLLVTSLQQAHNWIAKNDRNKMAFWSTVLFDDETLADETEANDGEFRPDVAKTEVQNWFERNSRLCEKARLLLREYEANVASHGYPGHLHRDSPLAWNWLPEGSVPVRADDADNDTKITPQWNEDEPDKFEQDKAYGRVSREIDTWWLKNRDPNYDDWVVPMPTVEFAQQRTENCKANLLNRYVHSYRVAEHEGSVHSAEGVQSEGAGEEGREGGGHYTHDYGEEMIEEESIDDDDSYGEGPMNGLLTEVPNILDPKQIEALHMIVKSCILDNAGLALSRAGENLQKTRCRMFLALECGRSLLREILVFIAVWEKSEQSLIFQLTTQIVEAIHHSALIPFAWQSLRIPKDIMSPAQTVLLRLINNMFRARNNDPPPPDSKEHLRDVKLLHFLFIQFRSRIVPECVALMHLQAQIRNGLCDPADFPVDSWDMERAKDGIQQFLELFTTVNELPETRQYLIEWEAVYEMITLLKGLDAGVQKKPMVELPARSAAQRHHPPPPPHHDDPDAGYDSEDGPLVPGPPLEEPAHKYPWAGIKGQILHILAGLLQPPPGRSSPGNPIVQHQILRHNGIIALLNCCVYDDYNRFARERVQICLKWLMDGCDEANRYLRDLLASAPPPPSLRPTAGDGGPATATVRIDGIAGEVKVRRRDPGDPPLPPPRQGRVPGAAAVATMMDMTDVLPPENTLPPIRAPGERAGGRSRPDELLRDIITLADEAARLAIGGRVDGDETEEDDDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0S937</accession>
    <name>G0S937_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0044410</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694833.1">
        <property type="nucleotide sequence ID" value="XM_006694770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S937"/>
    <dbReference type="GeneID" id="18258479"/>
    <dbReference type="KEGG" id="cthr:CTHT_0044410"/>
    <dbReference type="eggNOG" id="KOG2132">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054409_0_1_1"/>
    <dbReference type="OMA" id="STEMMEG"/>
    <dbReference type="OrthoDB" id="263283at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF105">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="215"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="406" mass="45960" checksum="97099B8F24833F24" modified="2011-10-19" version="1">MLVSSPFSRRLVANTGDVSQKVLRLIGPCIRRNFASDSSPPSGTISRGKYRFLDLLPREQEKWMTLRDLTSHNSKIAVVVIRANRNKKQQKASSTQPAIALPALSKWFTSSSGWIDFSATLEPHSECMVPYELLVPATVVEELPQDSPLATFLQWLAKQEQPLYQQLKDSLEYNINLGRLVPKADTETSKTRFIRFEAPLGLLLAALKFNKHQPSTTGRLNNLYVAQARIEFLPHELQSDLPVPEVITSNGDGDLYASSVWFGLQPTYTPLHRDPNDNIFVQLCGTKVFRIMAPLAGGRMFNKVCTDLGRETGNSRLRGIEMMEEPERTAFFEAVWGKQAPVTSIHEVVLHPGDAMYLRTGFWHSVRAVGKEGNLNASVNWWFRWRNINHSKVEEDGKNFKSQRHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9U0</accession>
    <name>G0S9U0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative guanine nucleotide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0047160</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2022" name="Nat. Commun." volume="13" first="476" last="476">
            <title>High-resolution structures of a thermophilic eukaryotic 80S ribosome reveal atomistic details of translocation.</title>
            <authorList>
                <person name="Kisonaite M."/>
                <person name="Wild K."/>
                <person name="Lapouge K."/>
                <person name="Ruppert T."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="35079002"/>
            <dbReference type="DOI" id="10.1038/s41467-022-27967-9"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.90 ANGSTROMS)</scope>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2023" name="Nat. Struct. Mol. Biol." volume="30" first="670" last="677">
            <title>Structural inventory of cotranslational protein folding by the eukaryotic RAC complex.</title>
            <authorList>
                <person name="Kisonaite M."/>
                <person name="Wild K."/>
                <person name="Lapouge K."/>
                <person name="Gese G.V."/>
                <person name="Kellner N."/>
                <person name="Hurt E."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="37081320"/>
            <dbReference type="DOI" id="10.1038/s41594-023-00973-1"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.20 ANGSTROMS)</scope>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2024" name="Nat. Commun." volume="15" first="716" last="716">
            <title>Methionine aminopeptidase 2 and its autoproteolysis product have different binding sites on the ribosome.</title>
            <authorList>
                <person name="Klein M.A."/>
                <person name="Wild K."/>
                <person name="Kisonaite M."/>
                <person name="Sinning I."/>
            </authorList>
            <dbReference type="PubMed" id="38267453"/>
            <dbReference type="DOI" id="10.1038/s41467-024-44862-7"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.10 ANGSTROMS)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695086.1">
        <property type="nucleotide sequence ID" value="XM_006695023.1"/>
    </dbReference>
    <dbReference type="PDB" id="7OLC">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="A=1-316"/>
    </dbReference>
    <dbReference type="PDB" id="7OLD">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="A=1-316"/>
    </dbReference>
    <dbReference type="PDB" id="7Z3N">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="A=1-316"/>
    </dbReference>
    <dbReference type="PDB" id="7Z3O">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.30 A"/>
        <property type="chains" value="A=1-316"/>
    </dbReference>
    <dbReference type="PDB" id="8OO0">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="A=1-316"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9U0"/>
    <dbReference type="EMDB" id="EMD-12976"/>
    <dbReference type="EMDB" id="EMD-12977"/>
    <dbReference type="EMDB" id="EMD-14479"/>
    <dbReference type="EMDB" id="EMD-14480"/>
    <dbReference type="EMDB" id="EMD-17004"/>
    <dbReference type="STRING" id="759272.G0S9U0"/>
    <dbReference type="GeneID" id="18258754"/>
    <dbReference type="KEGG" id="cthr:CTHT_0047160"/>
    <dbReference type="eggNOG" id="KOG0279">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_7_1"/>
    <dbReference type="OMA" id="NCKLKIN"/>
    <dbReference type="OrthoDB" id="7875889at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045182">
        <property type="term" value="F:translation regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000039">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit beta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045223">
        <property type="entry name" value="RACK1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19868">
        <property type="entry name" value="RECEPTOR FOR ACTIVATED PROTEIN KINASE C RACK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7 8 9" id="KW-0002">3D-structure</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="11"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="59"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="101"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="144"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="188"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="288"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS20201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="7OLC"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="7OLD"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="7Z3N"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="7Z3O"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="8OO0"/>
        </source>
    </evidence>
    <sequence length="316" mass="35107" checksum="79937DD914234F8A" modified="2011-10-19" version="1">MAEQLILKGTLEGHNGWVTSLATSMENPNMLLSGSRDKTLIIWNLTRDETQYGYPKRRLHGHSHIVSDCVISSDGAYALSASWDKTLRLWELSTGTTTRRFVGHTGDVLSVSFSADNRQIVSGSRDKTIKLWNTLGDCKYTITDKGHTEWVSCVRFSPNPQNPVIVSCGWDKLVKVWDLQSCKLQTDHIGHTGYINTVTISPDGSLCASGGKDGTTMLWDLNESKHLYSLNANDEIHALVFSPNRYWLCAATASSIIIFDLEKKSKVDELKPEFQNVGKKSREPECVSLAWSADGQTLFAGYTDGIIRAWGVMSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9X7</accession>
    <name>G0S9X7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0047540</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695123.1">
        <property type="nucleotide sequence ID" value="XM_006695060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9X7"/>
    <dbReference type="GeneID" id="18258792"/>
    <dbReference type="KEGG" id="cthr:CTHT_0047540"/>
    <dbReference type="HOGENOM" id="CLU_1053758_0_0_1"/>
    <dbReference type="OrthoDB" id="4842715at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS20238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="264" mass="28757" checksum="76D2FA156E847F20" modified="2011-10-19" version="1">MVYRKLCKEARVNFYKERISAATSSAEWGRILRWRKDALDDRPTVIIVDCRVVSDTEQVAALAAYYPLSTFSKGVERLLAPRMTVAALCSSLLSPDVAGAIPSRPALDLVQLLVHHAETMARQGYHGLLVTRGLSLRVDPNKTEVPYIPPPPRRHRSEAWQDRPHNNFDPGGEDVLPPLISPLEGGGNSIGGGVDQALIQHEASGLSPSAGPKIFDTVVIPSLLYGMVQLDTGPTRAAVNSRLVPFRLTPVWSSLTKVANAALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0SA17</accession>
    <name>G0SA17_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Molybdate-anion transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Molybdate transporter 2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0040670</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694474.1">
        <property type="nucleotide sequence ID" value="XM_006694411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SA17"/>
    <dbReference type="STRING" id="759272.G0SA17"/>
    <dbReference type="GeneID" id="18258105"/>
    <dbReference type="KEGG" id="cthr:CTHT_0040670"/>
    <dbReference type="eggNOG" id="KOG4332">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1434295_0_0_1"/>
    <dbReference type="OrthoDB" id="263957at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008509">
        <property type="entry name" value="MOT2/MFSD5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23516:SF1">
        <property type="entry name" value="MOLYBDATE-ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23516">
        <property type="entry name" value="SAM (S-ADENOSYL METHIONINE) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05631">
        <property type="entry name" value="MFS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS19589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="189" mass="20770" checksum="BB405C5C7EAFC937" modified="2011-10-19" version="1">MTLFQPAVLVLCLGCTLFEGSMYLFVFLWAPVLQSVQSTPTELPYGHIFSSFMTAALAASLAFNIFVTDRRLVRPSVLLISLLAGSARCFIASANPHSEQSAFWVFCLFEGAVGAYWPYMGYLEVRLIDDKTRTQVYAMLRISLNVSVVVSLLLVTRRTGTFKMVFSVCGTLLLASSGAIWLALSATNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0SA42</accession>
    <name>G0SA42_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">ATP-dependent RNA helicase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0040930</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694499.1">
        <property type="nucleotide sequence ID" value="XM_006694436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SA42"/>
    <dbReference type="SMR" id="G0SA42"/>
    <dbReference type="STRING" id="759272.G0SA42"/>
    <dbReference type="GeneID" id="18258131"/>
    <dbReference type="KEGG" id="cthr:CTHT_0040930"/>
    <dbReference type="eggNOG" id="KOG0347">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_13_0_1"/>
    <dbReference type="OMA" id="QMIQKAR"/>
    <dbReference type="OrthoDB" id="4310724at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17946">
        <property type="entry name" value="DEADc_DDX24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF24">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="197"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="228"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="454"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="79"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="696"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="197"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="704"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS19614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="767" mass="84978" checksum="37EAD37FD173AA0C" modified="2011-10-19" version="1">MGFDKKRKRSDSAVKRFKGQGNSAKRQKTSVEKRVVHVDKLPWKTVDVLEMFDDAEGFYGLEEVTGVEVIREGNTVKFVAAVPPSDESEEFKGFDDVPEEEPHAAGEATESTESKTTDGTEVSFTDSAATEPTKEEEKDSRPQEPQQDQKRGKKDKKNKKTAKTQQPEADPELETNVFAQAAAIADVEAAEDDVDLSEWVPLGLSPPVLSCIARLKFLKPTPIQARAIPEVINGHDVIGKAATGSGKTLAFGIPIVEAWLSKIASAESSGQKHPIALILSPTRELAHQITDHLKQLCAGLATAPYICSVTGGLAVQKQERQLQKADIVVGTPGRLWEVMSTSNAVMQSFRSISFLVVDEADRILKDGHFKEAEKILLALDRTVPGEEEENDSDDEKTSRRRRQTLVFSATFNKALQQKLAGKARYNLMGETESLEYLLKRLNFREHPKFIDTNPITQMAENLKEGLIQCGDMEKDLYLYAVLLLQPTRRALVFTNSINTVRRLTAFLNNLNLPVFALHSEMEQKARLRSIERFKADNHPNKSKSNNAASILVATDVAARGLDIPLIDLVVHYHVPRSADDYVHRSGRTARASNSGVSILLCGPKEAIPTQRLINKVHAAAAAKNSNPVKSTKALGVQTIDIDRRLVQCLRPRVTLSQKITEATMAKERGAKEDEWLRKAAEELGVDPEEAEELGVWKGKGSGKKQREREARMTTKAEMKQMRWELKELLSKRVNNGVSEKYLRGVDVESLLQGARGEFLGVVEGLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0SA61</accession>
    <name>G0SA61_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pyrroloquinoline quinone-dependent pyranose dehydrogenase beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0041120</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694518.1">
        <property type="nucleotide sequence ID" value="XM_006694455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SA61"/>
    <dbReference type="GeneID" id="18258150"/>
    <dbReference type="KEGG" id="cthr:CTHT_0041120"/>
    <dbReference type="eggNOG" id="ENOG502QPZ1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039534_1_1_1"/>
    <dbReference type="OMA" id="EINHHWT"/>
    <dbReference type="OrthoDB" id="507128at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054539">
        <property type="entry name" value="Beta-prop_PDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH_b-prop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22807">
        <property type="entry name" value="TrAA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="Soluble quinoprotein glucose dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408943" description="Pyrroloquinoline quinone-dependent pyranose dehydrogenase beta-propeller domain-containing protein" evidence="2">
        <location>
            <begin position="31"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroloquinoline quinone-dependent pyranose dehydrogenase beta-propeller" evidence="3">
        <location>
            <begin position="48"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS19633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="507" mass="54510" checksum="C85A3DD105D7C225" modified="2011-10-19" version="1">MSLTSAFVGNLMRALTTVSGLALWVSAVAAAQTTTACETVLTPSYTSPVVAPGWKAALVAKGLTKPRGIIFDRKGRLLVVQQGVGVTRLDLVDHGDTCIWMSTSETILSDSQGQDQFGYNHGIEISADGRMLLVSTSEAVHAWLYDSERGRITKDSMRVLIRNMTSAGHVTRSLLLTRNQPPPSNPGDDGEEMPPRTYLLVSRGSSANVDTLAGDATSGISQIRAFDVAELYQATTPVDYASGGRLVGWGLRNSVGMGEHPATGSIWSVENSADDMARAGQDVHQDNPGEELNYHGTVESIFSEKADEALESKNRNYGYPFCYALWNTTDFPELGELKVGDQFMSNPDSKTGDQKCADEFISPRLTFQAHMAPLDIKFDPKNNGSRVFISFHGSWNRDVPVGYKLSYVNFSAKTGQPIPAADSVDSLVDIMTAADVTKCGLTRCFRPVGLAFDSTGERLFVSSDDTGEIWVIMEDKSENGQSGKGGDGFLGTGGGPNSSAGREYAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAD5</accession>
    <name>G0SAD5_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0041890</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694592.1">
        <property type="nucleotide sequence ID" value="XM_006694529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAD5"/>
    <dbReference type="STRING" id="759272.G0SAD5"/>
    <dbReference type="GeneID" id="18258227"/>
    <dbReference type="KEGG" id="cthr:CTHT_0041890"/>
    <dbReference type="eggNOG" id="KOG0569">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_5_1"/>
    <dbReference type="OMA" id="WAITASF"/>
    <dbReference type="OrthoDB" id="4540492at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF8">
        <property type="entry name" value="FACILITATED GLUCOSE TRANSPORTER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="15"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS19707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="504" mass="53574" checksum="64F607B8F887DCAF" modified="2011-10-19" version="1">MTSPQKDVTPYLVVLVLIAVLGPLQFGYHLAELNAPQDVLTCASPKPPSIVSRFFSFSSKQVDNDTDCIPMTPPTFAAISSVFTLGGLLGSLTSGPLTSRYGRLLCMRFTSLFFLVGSVIAYLATSAPALGVSRFLTGTAAGASTVIVPLYISEVVPAERRGFFGSWTQVGVNVGILGTQSLGYSVSEGGKGEWRWVFIVGVGIAIVQIVGLGGVVESPKWLGGVKGDVAKARRALQRIRGRSSGVEEEIASWGVTPTPTERQRLLDEEAEAPSLLQPVSPTRSKPITLGFLQVLTDPLTRPAILAVVGIMFAQQLCGINSIIMYSVSLLKDLLPISSGILTILISIINLAATIASSPLPDRLGRKTCILLSIAGQGTSSLILALSIVFNYKLLSAFAVLFFVAFFAVGLGPVPFILASELVGPEAVGAAQSWALGANYVATFLVAYLFPIVNEELNRVLGGAGWVYFIFAGFAVAAGVFVTKRVPETRGKGWEEVWGRERRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAS7</accession>
    <name>G0SAS7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0047600</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable lipid hydrolase.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695129.1">
        <property type="nucleotide sequence ID" value="XM_006695066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAS7"/>
    <dbReference type="STRING" id="759272.G0SAS7"/>
    <dbReference type="GeneID" id="18258798"/>
    <dbReference type="KEGG" id="cthr:CTHT_0047600"/>
    <dbReference type="eggNOG" id="KOG2214">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_272017_0_0_1"/>
    <dbReference type="OrthoDB" id="10049244at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF10">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="8">
        <location>
            <begin position="219"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="644"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="780"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="876"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1046"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="5">
        <location>
            <begin position="250"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="654"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="833"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="876"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="904"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="948"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1104"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1143"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS19307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1189" mass="132538" checksum="160A9B413038FCEF" modified="2011-10-19" version="1">MFPNKRHSAPSADNSNTRIPLLPSAVSSNVVRAARIGGSVLSGALSTANRASNLLLSVRHGLSSSQRQEARRREERMAELAEQMRNAKSLKDWEQAAKELDMLEGNEAWKEDDDDPEYNAQEIRQALDELLEARSKHDREHQLYIIKTGLRRDLGRMHRRELWCHSYIGTKRLIERYTSTVIETIEQIVADALDRDNETAMVLMQDLTEARANYGRTALCLSGGATLGMTHIGVCKAMYESGLLPYIISGASAGSIIAAVLCSKREEEYESLIQEFPYRDLDVFSPKDATWADYFRTMISQRAVCDIQGLIRVMRSWLGDTTFIEAYHRTRRILNICVTPKEKHDLPTLLNYLTSPHVLIWSAVAASCNLPPVFKSIPLMMKDPSTGEFLPWQPPPRDYIDGSFHHDVPMARLAELFGVSQLVVSQVNPHIVPFLDQNDMLEPSDSPRQRKPGERGFNVSKLATKVKEMAVDEICHRIRTVREVTPLPYGVDNFLDKFHRIMSQNYHGDVTIWPRPSFSDTMRLIANPDPSFMLRQCEVGERAAWPKMSQLRVKLGIEMALDRAVMVLRDKVFFTQNAADLRRKEAGVPDLVSPEPRFVKVVRRPKVKSEVDEEDEESPEEWVLGPKRHSWSCLRFAVQSDFSPFATPEVSPEGTDEEKPNEEEEDGLWIDFSRQRKRQKERSMMMMMMMKMGKRKAYSAHTSPVRRSKSIAQLWSPEVIERLAKTKLRPFEPGELTMPPLRGEVGVRVGGVNTVNGLSTSEEEGVWKRKRRVSFADERGGTLEMGPTPVGTEAQPGNRRASVERRRASVGQVSIPIVTPKRRTASVEEPGESSEMAAARARASGRRSFVPDEDEACLDGVVERQGCLGPIVEASFESSMSSTPGQRSTSGEPSNSPPLLVQASESSPSPTSSGIDKITSTSGTTSGSTSTDSSARIMSLNRDIKLPLSPPPPRPRSPPLELMWGEDGSSDVDLESFVGDPDPYHEDEGMSGNSVGPWFDGEEGEDGGDWHGVAAEPAGTGKRGVVKQKEERGVRARLPVWSAPDWVGEASEDGKADEMSEVSPLTTDVPGRDKQRVPSLVVTPASLPTSPPQEGFAKQNSDSYKPEEKPQPGEVVEREREASTVGEEVFEDAEEWLSPGPDPEPKADEPKHETEVGESEKNATTGKKREREKRKLAQDEWDDLFGPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAT3</accession>
    <name>G0SAT3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">GPI transamidase component PIG-S-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0047690</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGS family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695135.1">
        <property type="nucleotide sequence ID" value="XM_006695072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAT3"/>
    <dbReference type="STRING" id="759272.G0SAT3"/>
    <dbReference type="GeneID" id="18258807"/>
    <dbReference type="KEGG" id="cthr:CTHT_0047690"/>
    <dbReference type="eggNOG" id="KOG2459">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010026_1_0_1"/>
    <dbReference type="OMA" id="AEHKYAV"/>
    <dbReference type="OrthoDB" id="28748at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019540">
        <property type="entry name" value="PtdIno-glycan_biosynth_class_S"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072:SF13">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10510">
        <property type="entry name" value="PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS19313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="578" mass="62823" checksum="AB189FC818534C1B" modified="2011-10-19" version="1">MHDPITHVKPRAEWALIDMGRPCVPGNVTARVIKHPVAGSASTSKVQRLGAEGCITMTTPQPLWKEPPPEKPADKRRRGFVILSFWLIVVLLGLPIWWQTTTIYRADLPLQEMLDWAEGRACRPVFPLRIAVQAPSLHDHEAQTLVRLTQHALDDLNDFAGHHLRLSLAKQSAPSADLDVVLTVRLLPGDATTAHLDPYEPVLHVTYPPNAIPSASASSSTLATYIASTLREAFAEEQATISYLLSANGSSPSSGEPRPLGQGLAPDVAESLAKRSTRALRYAPTYHLTFSLFTSGSTPSSWDIEKAIEDYMKPVLDVLSPIHNFTIDTQIQLYATPGVQNQVLTKEDLSSFINAAEWPLSPSIGGAPTINFVVFIGNQTIYIPSSSGSESVSSHSWLIPQWGAVYLLPLTSGTAHLPSHELKHPLLTFTSHLLTLTGTPHSGSLPLRLSSLSRIRSADLLLRASSTLGSLARLVVALPSISIPPSVADGVATTLSHLRHACYTLGMPEALYHARVAEAAAERAFFEKSMVGQLYFPDEHKVAVYLPLLGPVAVPLLMGAWNEILGWVRRRGVKGKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBI2</accession>
    <name>G0SBI2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0053670</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695703.1">
        <property type="nucleotide sequence ID" value="XM_006695640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBI2"/>
    <dbReference type="GeneID" id="18259405"/>
    <dbReference type="KEGG" id="cthr:CTHT_0053670"/>
    <dbReference type="eggNOG" id="ENOG502S3S2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082191_2_0_1"/>
    <dbReference type="OrthoDB" id="3063476at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053203">
        <property type="entry name" value="Cisplatin_resist-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022024">
        <property type="entry name" value="DUF3602"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693:SF1">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12223">
        <property type="entry name" value="DUF3602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="165" mass="17134" checksum="C18EE6A596E0E3AD" modified="2011-10-19" version="1">MSHMQSSGRGGAGNIVDSSKAPQIQPKDLETPTLKSEMVTTGRGGTGNMAANLDAEEKRRLQDVEPVVRRETQTAHIGRGGTGNVVKAGADASDEITSAAPGSPNLLTKIKSNVLGGGDAKEEKKERSSGEGDAPETGAAHSRRKSESTGQGLVEKGINRLFGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBJ9</accession>
    <name>G0SBJ9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0053840</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695720.1">
        <property type="nucleotide sequence ID" value="XM_006695657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBJ9"/>
    <dbReference type="STRING" id="759272.G0SBJ9"/>
    <dbReference type="GeneID" id="18259422"/>
    <dbReference type="KEGG" id="cthr:CTHT_0053840"/>
    <dbReference type="eggNOG" id="ENOG502QS3B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003963_1_0_1"/>
    <dbReference type="OMA" id="NPYPEYH"/>
    <dbReference type="OrthoDB" id="2419400at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000028">
        <property type="entry name" value="WW domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043904">
        <property type="entry name" value="PhoD_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689:SF2">
        <property type="entry name" value="WW DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G06520)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19050">
        <property type="entry name" value="PhoD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="551"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="366"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS18775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1278" mass="137981" checksum="2887DCF7B649A539" modified="2011-10-19" version="1">MGSRSRDVPENELFLSRPAPSVEDCDSPTVEPLRIFKPQSPANGQSANRPKYPAVSSSSSVAATSSSSSSSTKPSIASLPPLPSFPFAPGATSSANPLPYPDDDKPKISKPSSRLPYPLDDDERKTSPKPSPTSRIGSPPPASSSSRLGEFPLRPTVSTGDKRTVAERRGSTVPKPLSPASLSDDDGELFAKPLRNQTAPVSSSTTKISEAYKQKPYYPPPAGSGSQTNQGANLNRFSSTASTSTTRASRGSPPPPETPIVEPGVVPGGDIEARYAASGIPGTATLNSLQISSIQTSAAAQARMAQYAGQRPTVQPHQQQQQQQQQQQQQQQQQQQPPARPWTPTEPPGQNPYGPPTVYQGDSIVSSPAPQQPTTSTAASTATASAPSAPVFNLPHNPNPVTHVPPASLQVSILEQEFQRLQTSTPPPAYNTINPDAGPSFPNEKAQPPPGAEHPSTTSVNVAPAVNGATAAPVHPAQVQPVANTAASQKQAMAAAQYPVTTAAAAPSTAASATAAAQAHNAGHPAFANDAKQQPGLTHTPSLLAAAQQPPPLPEGWIAALDQNSGQYYYIHLATQATQWEFPKGPQPLNHDPAPMSPALSTYGNPLASPFLGSGKAGLASPMFHGARPGYAESIMSGVAPTVGGFSGPPPSAGVELYKIQPANGVYFGPYLRYVNMDLERGIWYGSIMLVTDAPQPPTIHIHLSHDLSPNPRQLIPQNIYTHQRWVFYKYDVDLQMADHGTERWTYAVTSHLGCTRYEFVVAGRYETGWRILAHSGNDFSTSTNQNERAKLGGVTFMWKDILQKNVECGGFHVQLGLGGQIYGDRLWKEVPLLKQWLGMQGRENRKSAPWTARHQEDVAHAYFHYYTSHFDQPFIREAFAQIPHVCQIDDHDIFDGFGSYPDYMQQSNVFKGIGRIAIEMYLLFQHHTTVEILRNISSDRDLFTITGTGWHFVKFLGPAVVVVGPDCRSERTLNRVMDGPTYQGIFPKVAMLPPSVQHCIWMISVPVIYPRLETVETLANTFATGKKAVNTTYNLLGKVTSSVAGVVGGKEVVQQGFKEVKKVVGKSGLMGSVLNQFGEIDIAEELKDLWTHESKDLERTYLIRTLQGIAKQKGIRMTFLSGDVNCCGAGLVHDPAHPHDHKTMYQIIASPVVAAPCSNYLIKMLHNNKLLYVPQNGHRSTHEVSDTKEDMMEIFHTEASGATREHKKLMARRNYVAIIAYDPEALQNGYAGSVNSNGSGGLGKLSLAVDFVVQSDGPFQATTKYGPVIIPHLEFGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBQ8</accession>
    <name>G0SBQ8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative mitochondrial ornithine carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0054440</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695779.1">
        <property type="nucleotide sequence ID" value="XM_006695716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBQ8"/>
    <dbReference type="STRING" id="759272.G0SBQ8"/>
    <dbReference type="GeneID" id="18259482"/>
    <dbReference type="KEGG" id="cthr:CTHT_0054440"/>
    <dbReference type="eggNOG" id="KOG0758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_16_3_1"/>
    <dbReference type="OMA" id="PIDCFRQ"/>
    <dbReference type="OrthoDB" id="2139348at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000109">
        <property type="entry name" value="Ornithine carrier protein AmcA/Ort1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF31">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="23"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="124"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="239"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS18834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="335" mass="36570" checksum="296EBA3CA243EFC4" modified="2011-10-19" version="1">MEPTILSDAATAPVQVSRRTAAVEAFEDIVYGSVAGIVGKYIEYPFDTVKVRLQSQPDHRPLQYKGPLDCFRQSIRADGFLGLYRGISAPLVGAALENSSLFFWERIGRAAIYASGYAPREQPLPLSALWMTGAFSGAMTSFILTPVELVKCKIQVPGKGEAGAPTAHLKPIPVIRDIFRHQGLRGFWHGQLGTFLRESGGCAAWFGSKETVTKFFRDWNDRRAAASGIPNPIKDDDPLPLWQQAIAGASAGMSYNFLFFPADTVKSRMQTTPIGELASGAMPQRTFAGEAAALWKQAGITGFYRGCGITVLRSVPSSAFIFMVYDGLKKYLPMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBR8</accession>
    <name>G0SBR8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0054550</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695789.1">
        <property type="nucleotide sequence ID" value="XM_006695726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBR8"/>
    <dbReference type="GeneID" id="18259493"/>
    <dbReference type="KEGG" id="cthr:CTHT_0054550"/>
    <dbReference type="eggNOG" id="ENOG502S8F1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131051_0_0_1"/>
    <dbReference type="OMA" id="YDWGRWV"/>
    <dbReference type="OrthoDB" id="3556830at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020999">
        <property type="entry name" value="Chitin_synth_reg_RCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28187">
        <property type="entry name" value="PROTEIN RCR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28187:SF1">
        <property type="entry name" value="PROTEIN RCR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12273">
        <property type="entry name" value="RCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS18844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="170" mass="19139" checksum="DDF72B03D74950BB" modified="2011-10-19" version="1">MQETRLAKRENGCGPGRYLGVDGNCYQYSDWYWWGRWVFAGLALLCILIVFFLLFRASRRRRRQGLQPLWGTGWMAGPPPPYYPPPPQYTPQDPNSEGYKYYQPAGYYAAPPNGAGPSDTTGYYAGNQEGIQLQQPPTAYHRDSNNPNNVDYPPPPGPPPSHANSNNNKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBT7</accession>
    <name>G0SBT7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0054740</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695808.1">
        <property type="nucleotide sequence ID" value="XM_006695745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBT7"/>
    <dbReference type="STRING" id="759272.G0SBT7"/>
    <dbReference type="GeneID" id="18259512"/>
    <dbReference type="KEGG" id="cthr:CTHT_0054740"/>
    <dbReference type="eggNOG" id="ENOG502SDN7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060774_0_0_1"/>
    <dbReference type="OMA" id="QTFHYLE"/>
    <dbReference type="OrthoDB" id="5422283at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024771">
        <property type="entry name" value="SUZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024642">
        <property type="entry name" value="SUZ-C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12752">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51673">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51938">
        <property type="entry name" value="SUZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUZ" evidence="2">
        <location>
            <begin position="60"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="SUZ-C" evidence="3">
        <location>
            <begin position="205"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS18863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="259" mass="28986" checksum="8342401F33ECD484" modified="2011-10-19" version="1">MSSSKKVPDVWDDEDWEVQADRLAKEPPEPDPEPRRLTRAELMAKHAEENRRLWEEADAPQEPPVFVSVNDNLPLTTPFKQPIKVLSRKPTPHVISRKDPITGMPQESPEEIRQRQQRELEEKQRRYQEARAKIFGESNPSSGQSSPGSVTPPEGRLGGSHGHRGRGRGRGGRGRGDRDRDRDGGRQDRRQTQLGGETRELYDPKKGGYSVQRRGDASPHQGSGSRVPKDDTQPIRSPRGPDGSGRGFGFARRGRSEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBU6</accession>
    <name>G0SBU6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0054840</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695817.1">
        <property type="nucleotide sequence ID" value="XM_006695754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBU6"/>
    <dbReference type="GeneID" id="18259522"/>
    <dbReference type="KEGG" id="cthr:CTHT_0054840"/>
    <dbReference type="eggNOG" id="ENOG502RJWF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093929_0_0_1"/>
    <dbReference type="OMA" id="YEPIFTI"/>
    <dbReference type="OrthoDB" id="5199481at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409037" evidence="1">
        <location>
            <begin position="18"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="183" mass="19982" checksum="7165A57E5AB4F506" modified="2011-10-19" version="1">MQLLAFLPVLLASSGLASPVCRNVNQPIYTLRLASPEPSLHNRPLTITNNSTLGVSASPEVKDEVHFYTVVNPTTGLAELHTSSPVNDATLTLIGSNGVLDFTPLKNPAAVTVPVGTTVDWTSFELDEGTPGEGTVKYVGKEGRWVMFPEGDEWELKWRSADAWTIETYIPVQVVYELVKEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBU9</accession>
    <name>G0SBU9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ubiquitin-protein ligase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0054870</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sel-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695820.1">
        <property type="nucleotide sequence ID" value="XM_006695757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBU9"/>
    <dbReference type="STRING" id="759272.G0SBU9"/>
    <dbReference type="GeneID" id="18259525"/>
    <dbReference type="KEGG" id="cthr:CTHT_0054870"/>
    <dbReference type="eggNOG" id="KOG1550">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007931_0_0_1"/>
    <dbReference type="OMA" id="MDLQARK"/>
    <dbReference type="OrthoDB" id="27934at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF147">
        <property type="entry name" value="SEL1L ADAPTOR SUBUNIT OF ERAD E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409109" evidence="4">
        <location>
            <begin position="21"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="756"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="792"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="792"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS18875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="842" mass="94579" checksum="E95E4957F3124C33" modified="2011-10-19" version="1">MWRYVLWLLLLLQSIAFTSANLHTEQHVLGGKSSKATTGDSSGAEIITAQAAGQTVREPGAELVESALTELRKLYKPLHARARKPNGLFSALGQFVITALPTFRLTASPPEQAAASRMSNALRHATQLLEESARLNNSDALYILAEMNFYGNYSHPRNFKAAFGYYHQLALLNGNASAMYMLGLMYSTGIGGAVERDQARALLYYTFAANKGHTRAEMTVAHRHHAGIGTPKSCEVAARYYKRVADKAIEWYRSGPPGGRSWILEAHRIADDTGGAYGEGASVVSAGENSARSHPDSEASIEDIIEYLDLMAQKGDFKAAFNLGRIYYEGQRGLSKNMAIARRYFLDVVQKYWKKNRPIENPKGGLERFAGKAAGYIGRMYLRGEGVEQNFDRAKFWLERGSLLKDAQSQHFLGLMYLHGYGVKRDLPQAIDYFKAAASLDYAAAQVQLGILYLDQGNTEDLIAANHYFELAMRWGHIEAYYYMAEVNMYGVGRDPNCQQAVSYYKIVAERAEPIVSSWADANLAYESGNVELALLEYLGAAEQGYERAQNNVAHLLDPDKSRLPFLHRLLSPTPTSPLLHNPTLALIYWTRSARQSNIDALVKMGDYYLYGIGTEADVDKAVQCYTGASEYLQSAQALYNLGWMHEHGIGLDQDYHLAKRYYDSALETNEEAYLPVTLSLLKLRVKSAWNTLTHGRINSIQDEPAPKKEWSFREWINNFLQNDEGQYYEEYYDEYYDDSMPGGDPLDFEDGLTESLVILGLAAVLAFLIMYRNQRQQQVVRQQQMQAQQPQQGLGQQQQQAQGQQHGQQQAQQPAQHQEQQQQELFPQPGDPQFGQWAVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBW2</accession>
    <name>G0SBW2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MADS-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0055000</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MEF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695833.1">
        <property type="nucleotide sequence ID" value="XM_006695770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBW2"/>
    <dbReference type="STRING" id="759272.G0SBW2"/>
    <dbReference type="GeneID" id="18259538"/>
    <dbReference type="KEGG" id="cthr:CTHT_0055000"/>
    <dbReference type="eggNOG" id="KOG0014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024080_1_0_1"/>
    <dbReference type="OMA" id="LGRYQYF"/>
    <dbReference type="OrthoDB" id="1898716at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00265">
        <property type="entry name" value="MADS_MEF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033896">
        <property type="entry name" value="MEF2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945">
        <property type="entry name" value="MADS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945:SF534">
        <property type="entry name" value="MYOCYTE-SPECIFIC ENHANCER FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="8">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="75"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="218"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="622"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="121"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="291"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="368"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="447"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="473"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="516"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="555"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="674"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS18888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="684" mass="73938" checksum="401CA52C2E7051BB" modified="2011-10-19" version="1">MGRRKIEIKAIKDDRNRSVTFLKRKGGLFKKAHELSVLCCVDVAVFIFGNNKKLYEYSSTDMREMITRYTYALQHGGPNEHKGPQDFQTAAADDEEEDDDNNNNNNNNGTPPQNETGMESQMVVPPFQPQAQFPPQIRHQHAPSLSPPMPNGAVFGAHPANAPRGHTPQPQIGSRPASRNDIRRMPPNMVTQPVVSQAPPQPVNGGYAYMPQPAIYNPQNASLPPSMPTHGLPQPHPQFPYSQPAPQPPQMQPFVEDQRRPQPSPAFPPPHTQPTAPRHSLSPPQPPAPQLPAQFHPQPVTQMSAAPSQPQQPSAQPQQQSQPTAHQMQTPPQPQQQLPSLPPPQETSHNPEPTRTMEPPQIQQPASSMPPPHESQPPAPLEPKPIQEPERRQPTLLLDTNIKRLPPRGRGSIFTPIDENRSVLSQHLAAFAADKSSPPEPKPQPVSTSGSNNSSPSNGQRSNPQIVQPPQITRTTSLSSTTETVFTPPSRSNSLRTGGPLVRPRLKVQIPDESDNGSATGSASPKGTTTTNEATSQPSRLTHCSTVVLPPPSPSASALLSAGATGPPNPFARPLPQQNSNRDSIDTPVSALPSRFLNTDYLPSPSSFYPEWNLRGSDSNTLPSPLNFATPVVGTGPSFLRDDPAPPPSLLKRKSPEISGSNGNSGGEGSSEGNDAKRLKVEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0SC30</accession>
    <name>G0SC30_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha,alpha-trehalose phosphate synthase subunit-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0055710</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695901.1">
        <property type="nucleotide sequence ID" value="XM_006695838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SC30"/>
    <dbReference type="STRING" id="759272.G0SC30"/>
    <dbReference type="GeneID" id="18259609"/>
    <dbReference type="KEGG" id="cthr:CTHT_0055710"/>
    <dbReference type="eggNOG" id="KOG1050">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002351_2_2_1"/>
    <dbReference type="OMA" id="TSWDKRR"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000099">
        <property type="entry name" value="Alpha,alpha-trehalose phosphate synthase subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1020:FF:000001">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000036">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase subunit Tps2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1020">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase related protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF15">
        <property type="entry name" value="TREHALOSE SYNTHASE COMPLEX REGULATORY SUBUNIT TPS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="32"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS18956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="905" mass="102789" checksum="6483F5F2819DA5E8" modified="2011-10-19" version="1">MTVFIASLFLPKTVQFDVPVTNHRSAWSEKKYPFSTKPAKPSPLEQPPSLFQPTNITPPETPTDEKKRDNPFANEDGLRVHIPLSESSTDSIDGPADRSSPTWGGRPDQPMSRANSPPPPSIVDKGRLLQQAIGRQSFLKTRAARSGSHDRVFESANWRIVNADQGNGGLRNAALAAAREGFTGDYIWVGTLGMPIDALQGTQQLQDIEDKLATEHDMLAVLPSDKDFNGHYLHYCKQILWPVFHYQLPDNPKSKAYEDHSWKYYVNVNQAFADKIVKNWKRGDTIWVHDYHLLLLPAMIRKKLPDAKIGFFLHVAFPSSEIFRCLATRKDLLEGMLGANLIGFQIHEYTRHFLQTCSRLLNAEATPDGLQLEDRFVDVFNLPIGIDPVSLDQHRQEPKVQEWLEVLRKKFQGKKVIVARDKLDHVRGIKQKLQAFEIFLTQHPEWRTKMVLFQVALSSGEKSELDKTVSDIVTRVNSSHANLAHQPLVYLKQDIDYAQYLALMSIADGLMITSQREGMNLTSHEFVFCQDGKICEKKHGVLLLSEFTGTSSLFGGNELSINPWDYRACADAIMKAVTMNEEEKEARWTKLSEAVKRHTGAHWFTELMTRLDRVYEEQQRRDQTSVPRLSLHHLVQQYSRSQRRLFILDFEGTLVSWGPVNQIIPVSPQRTLDVLNDLLIDERNTIYVMSGRRPEELDRLFRRVPNLGLIAENGCFLKDCGSSTWTEMADPEQIRTWKEQVRGILTYYLERTPGAEIEDRRCSLIFHYKSAEDYESAMRQANDCASHINDACEEQRVHAIPLDGCVLVEPIDWTKSTAAQKIFDDLRTKMGPDEQHESPVDFLMVVGDGRDDEKVFRWANTLGKEGVVKEVVTVTLGTRNTEATATLTQGVSGVLLALQKLASMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0SC44</accession>
    <name>G0SC44_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0055870</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695915.1">
        <property type="nucleotide sequence ID" value="XM_006695852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SC44"/>
    <dbReference type="GeneID" id="18259625"/>
    <dbReference type="KEGG" id="cthr:CTHT_0055870"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004495_0_1_1"/>
    <dbReference type="OMA" id="CVQFVMT"/>
    <dbReference type="OrthoDB" id="10054429at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF9">
        <property type="entry name" value="AMINO-ACID PERMEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS18970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="40516" checksum="C561CFD2C4172D5C" modified="2011-10-19" version="1">MALSSSEHLDEADKKLEAMGYKPVFKREFSSWSTFSFAMSISGIYGSLISTWVYGLQAGGAAAIMWSWIVGGAGALALAVSLAELSSAYPNAGAMYYTLRFLAPEKHMPLLCWMSGWITLIGTIAGSASTEYATSQMLLGAISIATNSTYKPTVGHVVGAMALLTLIHAGINTLPTLWLTRLTSSYVVLHMTVLVSACVYLLVQTKNKNSLAYAFTDFQPTSGWSPPGFAILFGCLTPAWIMTSADSTARIAEEAKSPALTIPRAIFVASLSTYILGFVFNLVLVLCMGPGGPFPLLNSPSGQPVVELFTQALGRAPAIFFTLCGVIIMNMVAIPGAQAGSRMVFALARDELVPLARMWTRVDVKRGTPILAVWGEPEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0SC65</accession>
    <name>G0SC65_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative sugar:hydrogen symporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0056100</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695936.1">
        <property type="nucleotide sequence ID" value="XM_006695873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SC65"/>
    <dbReference type="GeneID" id="18259648"/>
    <dbReference type="KEGG" id="cthr:CTHT_0056100"/>
    <dbReference type="eggNOG" id="KOG0253">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_52_2_1"/>
    <dbReference type="OMA" id="LLWFIWM"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF12">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01740)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="457"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="99"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS18991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="514" mass="55208" checksum="DD4EDB36B01EBB32" modified="2011-10-19" version="1">MVNAYKSSSNAALGLSNSPIPFDVQDGESVAIQDEDTAIPSGQIDPVYEKKAKVLNRAVRPYQSVITLGSVGVAEFKEAHVLTYSQIQQIGMGAYQWQLFVVISFGWASDNLWPVTTSLILPPLIVEFLGPSPNASRIAPLLTLGQSIGLLLGALFWGFGSDAFGRRWAFSLTLGATGVFGLVAAGSSSFAAASVLVAAWSFGVGGNLPVDSAIFLEFLPASHQYLLTVLSAAWAIAQVVATLLAWPLLGRMTCQEEDPNTRCEKKDNMGWRWFLLVMGGMTMLMFLARFVLFTMHESPKYLMGKGKDEDAVKVVHEVARRNGKTSTLTVEELRACEPEGYPLYNSFLPYIQATRGLDFGDGSTYLTYRDSLIIAAVGVPGAFVGALLVEQPKLGRKGTLSLATVLTGAFLYASTTAVNSNALLGWNCAYSFTSNIMYAVLYSFTPELFPTPQRGTGNALSATCNRVFGIMAPLVAIFADLNTAVPVYISGGLFIAAGLLVLFLPFESRGKAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0SC95</accession>
    <name>G0SC95_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WIBG Mago-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0056420</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695966.1">
        <property type="nucleotide sequence ID" value="XM_006695903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SC95"/>
    <dbReference type="STRING" id="759272.G0SC95"/>
    <dbReference type="GeneID" id="18259680"/>
    <dbReference type="KEGG" id="cthr:CTHT_0056420"/>
    <dbReference type="eggNOG" id="KOG4325">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074603_1_0_1"/>
    <dbReference type="OMA" id="IPGCADS"/>
    <dbReference type="OrthoDB" id="21625at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903259">
        <property type="term" value="P:exon-exon junction complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039333">
        <property type="entry name" value="PYM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015362">
        <property type="entry name" value="WIBG_mago-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036348">
        <property type="entry name" value="WIBG_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22959:SF0">
        <property type="entry name" value="PARTNER OF Y14 AND MAGO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22959">
        <property type="entry name" value="PYM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09282">
        <property type="entry name" value="Mago-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01273">
        <property type="entry name" value="Mago-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101931">
        <property type="entry name" value="Pym (Within the bgcn gene intron protein, WIBG), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WIBG Mago-binding" evidence="2">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS19021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="215" mass="23655" checksum="FD3DA7B8DC315C3D" modified="2011-10-19" version="1">MPPQKLQTSNAGIVTDPKSGERIIPASVRADGSIRKEIRVRDGYIPPEDVAIYKNKRAEDFRNRGRGLPPGAEGLKDEVTKPAQSAAANKNAKRREARRKAKAAAEDGKVAEHNEQSETAAVPSEKTKSEEPPKQPDPEAEKEKKVRSLKKKLKQARELQVKKENGQALLPEQIAKVIKINELIRELKALGIEDVEDSKKSAKEASKTKASEPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCE5</accession>
    <name>G0SCE5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0056930</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696016.1">
        <property type="nucleotide sequence ID" value="XM_006695953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCE5"/>
    <dbReference type="STRING" id="759272.G0SCE5"/>
    <dbReference type="GeneID" id="18259731"/>
    <dbReference type="KEGG" id="cthr:CTHT_0056930"/>
    <dbReference type="eggNOG" id="KOG4391">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043841_1_0_1"/>
    <dbReference type="OMA" id="CFWIVVM"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF64">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS19071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="30057" checksum="BFE5079A533A28DC" modified="2011-10-19" version="1">MPGLPPNARWEKITDWEKHCGGLKWEEDRTVAEDGTDLAVVYATVPLPKSKSRALMATKEGPSAHVYILYRGYWTSRGRPSEPGLRLDAQAGARWIAERHERIYGKHSGTVPILLVWGQSIGSGVATNLAATGKLPANMPIRGLLLETPFVSIKAMLEAIYPQKWLPYKHLWPFLRNHLDSWANFGIIANACRKEGRPAPLVYILQAERDEIVPKEQSEQLYQRCLELGIPVERGIVPSAYHQQAITYGDGKALAAEAILKLIKAGLYNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCK4</accession>
    <name>G0SCK4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0057550</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696075.1">
        <property type="nucleotide sequence ID" value="XM_006696012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCK4"/>
    <dbReference type="STRING" id="759272.G0SCK4"/>
    <dbReference type="GeneID" id="18259793"/>
    <dbReference type="KEGG" id="cthr:CTHT_0057550"/>
    <dbReference type="eggNOG" id="KOG3998">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056195_0_0_1"/>
    <dbReference type="OMA" id="RHRHFPW"/>
    <dbReference type="OrthoDB" id="7859621at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002995">
        <property type="entry name" value="Surf4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02077">
        <property type="entry name" value="SURF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01339">
        <property type="entry name" value="SURF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS19130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="300" mass="33391" checksum="ABFF81DE8A5E5610" modified="2011-10-19" version="1">MAQLRGPGSYGIGAAPFGAPADDRNEQSALDTIRQHTSKIEDLLDTVSGPIKPFLPAIGRFLIVSTFLEDSIRIITQWSDQLIYLHNYRHIPNGITHLFLIGNVIAMTICSVLVILRKHSEKAVGGLIGVVIAQALGYGLIFDLNFFLRNLSVMGGLLMVLSDSWVRKTKVFAGLPQLEEKDRKMYFQLAGRVLLIFLFIGFVFSGEWSVWRILVSLVGFVACVMVVVGFKAKFSATLLVVILSVFNVLVNNFWTLHEHHPHKDFAKYDFFQILSIVGGLLLLVNSGPGQLSVDEKKKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCX4</accession>
    <name>G0SCX4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0058700</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696190.1">
        <property type="nucleotide sequence ID" value="XM_006696127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCX4"/>
    <dbReference type="STRING" id="759272.G0SCX4"/>
    <dbReference type="GeneID" id="18259908"/>
    <dbReference type="KEGG" id="cthr:CTHT_0058700"/>
    <dbReference type="eggNOG" id="KOG1993">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003886_1_0_1"/>
    <dbReference type="OMA" id="SFHYVFH"/>
    <dbReference type="OrthoDB" id="361693at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000362">
        <property type="entry name" value="Importin 11, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058669">
        <property type="entry name" value="TPR_IPO7/11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF7">
        <property type="entry name" value="IMPORTIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25758">
        <property type="entry name" value="TPR_IPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="5">
        <location>
            <begin position="38"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS19245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1045" mass="118672" checksum="6F508EF1ED181222" modified="2011-10-19" version="1">MNFAIEVPGEAVPLGPAELIKALSAASGSGDNAQRQSAGQQLQAWETHPDYYPSLQQIYLDKSLDKQVRFLAIILLKNGIDRYWRRTSKHAITPENKQLIRARLFQGSIDEEDKALCLHNALVTAKIVRIEYPDDWPDALPMLIRQTEMANFRSPVQLRGALTLMLRIVKELATARLRKSQTALQAVTPELVQFLGKLYTAKTAYWLRLWKEEIGDETTADYAIENSLLALRILRRLVTVGYEQPHTDSLVCSFWSLSQNQFDEFLSGLTPDSRMTVPYQDLVGKHLIQFTKLHIDMSEMHPASFPALPNTITLVRAYWKFIKDFSQVFAESSGIRQSSSESVSGNAKHEGPIGEKLALKGLLLLRSCIATAHRPVQTFKYRSPEVKELERQAVNTIKEELLTKDMLLDMVQVIISKLFVFRKSDLEAWEEDPENWESQERTEGGAYEWAIRPCAERLLLDLITHYRELGEPLLNYCQMATNSDMDIITKESAYCALGCAAAVIHQAFDFDSFVRNSLIKDVQIQDPLAKLLRRRIAILLSQWISIRVSQETRPIIYEIFRHLLNPNDQHNDEVVRITAARQLKVIAEDFEFIGEHFYPFASDTFNLLVGLLKQVEGDEAKYAILETIRVLVSRMETHIAEFGDAIMTTLPQIWESAGSEEYMIKQSVLAITSALILSMRTASQRYHSMIIPLLREAMNPESPLHLHLIEESVELWKSIMSQASPPLNPDLVQMFQLAIPLLDYDSEVTLDCLELAKDYILLAPQDVLTDAFRRPTLTALAKILDHKARERSQLAARSIELIIRVAEAFGGSQGVNVVAQDLLEIGALRTIFEGIHSSWEADQTTGPNKKQSKISTITETDYFILLARIALADPAVFANMLTSFGNTIDQVWSWLSPRWFANFDCMADIEREKLSCLALTRLWELPNPMQDLVLDKLQDYISMWTSVVTSLADDTPDTKGRDSLVWTEVPRTEYDTPRDVCENEFAAKDPVHTVSTFEFVKARLQDMVQRVGGEQAFEENWAINVDRDVLAGFQRLNQELGNTMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>G0SD37</accession>
    <name>G0SD37_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0050690</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695412.1">
        <property type="nucleotide sequence ID" value="XM_006695349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SD37"/>
    <dbReference type="GeneID" id="18259107"/>
    <dbReference type="KEGG" id="cthr:CTHT_0050690"/>
    <dbReference type="eggNOG" id="KOG1037">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011581_2_0_1"/>
    <dbReference type="OMA" id="AYQCARM"/>
    <dbReference type="OrthoDB" id="2017365at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF7">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="72"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="128"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS18467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="732" mass="79724" checksum="2B41597587B5FF25" modified="2011-10-19" version="1">MTTSPRPQKRTTNTCVTCRARKVRCDGRREICSNCERLGFSCSYDENVGVEMVSGEGNGMSISVPRRRVRQACQNCHARKARCSGSMPSCDRCRAQGLECVYRPGKRSLPLPPPVAIPSSTSAAGVAAAAAPGTANSPAMSSHDDGQPGQAVPNDYGASASSTTSPGSAAVDNTDPDEALALKAFDNFFRHVHHIAMFSFLHRPSLMERYHAGSLDRALLLAIIGITSLLTDLGPGMDAYGSRCIEDAVTMCLADLERPSIPRLQALVLAIKHRILSKRFSSAFMLHAIASRFAIALRLNHENPDLCFLAREARRRLMWTIYMIDSSIAAGQPEFALWADAERQIHLQLPCNERNFDFDLPEPTEPLRFPGPGPGGVVPPLPDVLGLMALHIRLHWMRNRILECTSRAVASPSQDALALLPGQCSELATELEAFEARLPASFRGCEANFRLRSYSPRLGIFVMTHVWWRQCHLDLYRIFLPGLKEALPPAALQQLDLHYVMNRRRTCYEHAKAMADMFSQLLTLGNKTPVADLDLPACAFQCTKILYHGVQMAEGAELGLTQERVQELANVCLRAARQSTPGPASAAIQSDIERLISNGLQLPETPASLQLSRARGPSITPGSEMPYLVEQIPDTDQMQGISHTPPAVQMPTLPPTTLSPMTALNMPVADPQVAAAVPPAPPSQTSAMTGASNAFEETADGFIFGPEMFGVDSWPALSHGWTNMTQFPGTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDJ2</accession>
    <name>G0SDJ2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">U3 small nucleolar RNA-associated protein 25</fullName>
            <shortName evidence="10">U3 snoRNA-associated protein 25</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0051980</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
            <location evidence="2 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the UTP25 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695538.1">
        <property type="nucleotide sequence ID" value="XM_006695475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDJ2"/>
    <dbReference type="STRING" id="759272.G0SDJ2"/>
    <dbReference type="GeneID" id="18259236"/>
    <dbReference type="KEGG" id="cthr:CTHT_0051980"/>
    <dbReference type="eggNOG" id="KOG2340">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018705_0_1_1"/>
    <dbReference type="OMA" id="QDRGDTF"/>
    <dbReference type="OrthoDB" id="10264378at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002356">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010678">
        <property type="entry name" value="UTP25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053939">
        <property type="entry name" value="UTP25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053940">
        <property type="entry name" value="UTP25_NTPase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933">
        <property type="entry name" value="ORF PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06862">
        <property type="entry name" value="Utp25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22916">
        <property type="entry name" value="UTP25_NTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7 10" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="UTP25 NTP hydrolase-like" evidence="13">
        <location>
            <begin position="253"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="UTP25 C-terminal" evidence="12">
        <location>
            <begin position="521"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS18593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="716" mass="82261" checksum="B3754099DD38FEC3" modified="2011-10-19" version="1">MAGGRSAKRKGRSTVRGRAKAGKGTAPVRSVKFHDARLDDDNSESEASASEPEAEVMDVDSDEGEEEEAKQPVQPYMALLRRLTESNPHKAKRRKLDHPSGENQERPQEVKEESAPQRQNGEDEEDRDVDLVEEPEEDPSNAPPEDLFDDDDDLDDTDPFEVHFSNPKEDMVQPRIKAIQEGKWRLERISSSQTRIFLNMPAVDGLEGKALIPPPVSGIKDLKLKKKLRESMEAKHPEFDQVEQTIAPALFNYQDLLFCNRTVANSQSLRRMACLHALNHVFKTRDRVIKNNSKLAKAGENEDLEFRDQGFTRPKVLWIMPTRAQCVKMLDMIVSIVQPDQQENRKRFEDGYVDKLSKFSDDKPEDFRDLFSGNDDDLFRLGVKFTRKTIKYFAQFYNSDMIFASPLGLRMAIGSEEEKKLDFDFLSSVELVIVDMAEALLMQNWEHMEFVFEHLNIQPRDAHGCDFSRVRSWYLDDQAKYFRQTVIFSAFNTPELAELVRAYCHNWAGKARLQQECPGMIQNLPVKARQTFSRFDSSSIAADPDARFAYFTKAIVPALTRHKARDAAGTLIFIPSYLDFVRVRNYFANNPAVENVSFGTISEYTDVPDASRARSHFLNGKQKVLLYTERAHHFRRYKIKGVKRVIFYSLPDNPVFYREIAGDYLQKSEQSLLLEPGQGVIRVMFSKYDVMKLERIVGTSRVGRMLHEQGDTFDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0SE44</accession>
    <name>G0SE44_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0062370</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696552.1">
        <property type="nucleotide sequence ID" value="XM_006696489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SE44"/>
    <dbReference type="STRING" id="759272.G0SE44"/>
    <dbReference type="GeneID" id="18260275"/>
    <dbReference type="KEGG" id="cthr:CTHT_0062370"/>
    <dbReference type="eggNOG" id="ENOG502SI13">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031053_0_0_1"/>
    <dbReference type="OMA" id="VVCRNCT"/>
    <dbReference type="OrthoDB" id="5288318at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="498" mass="54917" checksum="AE94E31408BC16D9" modified="2011-10-19" version="1">MAVFVDLDEEENGAQRNGDRPWNGRVDAVKPHPATVAIRDSETGDVVNISADAANQRSGHESVARENPNQNKAVTRALGCYPIIMAVASSIDLNTLDNLSRTCHQIRQSLLQYRKSLIGSTLRCSWDHLPVDPESTLRYRARAGNWWYMEDVSRSSYNGKSGRCARDLVSECRRCGTVVCRNCTIKQPAPVVLRDRHRRLCQACVNASLGSLVKPPLGPEIPVNSDDMERAICKCGTEGVWLCQPCGRSIRSDDGDYKSIWRWRHQYTNVLGGLGTGIGEGDRGVPCGRESECCAAREREQETDGDAEDAKGAQTFTEYQQQQQQLQQLQHMHEQQLSSDNPLIPSTISNGSVSSPFSSFPPEGTLTLNGTAPPFNGSHLLDNRRTPSPAFKPGYERHEVEGIGGVVKKLIVRTVKVGACVPEFPDEIIKGEILGREVRRERRSWCGWCKRVIPSMADYENDRSRREGGDSSKGDQPNGQGLEGRGKGKEKASASQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEE7</accession>
    <name>G0SEE7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0063480</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006696592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEE7"/>
    <dbReference type="STRING" id="759272.G0SEE7"/>
    <dbReference type="GeneID" id="18260386"/>
    <dbReference type="KEGG" id="cthr:CTHT_0063480"/>
    <dbReference type="eggNOG" id="ENOG502QPMX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012880_0_0_1"/>
    <dbReference type="OMA" id="QAQKYGE"/>
    <dbReference type="OrthoDB" id="5408998at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="177"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="262"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="459"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="612"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="738"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="475"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="497"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="556"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="580"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="613"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="710"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS18324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="831" mass="90590" checksum="DDD7D78CF2759C78" modified="2011-10-19" version="1">MTSHLLDDDIAPPPYSETDIYSATGANSSNNAGSGRNHPNYIPNTTPAEAVPQYASTDINDASSTVIYTPPGSSTPSEVAGPNSTQPHFPLDDQASYITNAAAQAYFSTRPAPLPPSGYTRPTLVYPITVTEDLGPDSLPYPPALGVRDINEQDWRTFVNFLGPWWVDVANQRAWERKRGTSPPPSTITTTTTAATIPGGFRSGEWDGGREKQGEGQEGERNEMPSWEERKRRMEETVREWNEGFFGPRGVRIRLNVPERTVVSRGEGDGMPEMREVPPMPISEEAGQSQGQDQGQEGQRDTAAEEARPSPSGSGGGFWNAFTTGFRARGSNRPNANASSNPSPSPHNPRHLSGGFHLGAIHVEPDRIAIGNAFVADGRTGTLKIGGIEAGPEGISINGTRVLSNPVPMHPPHRGFGHGPWGAARGPWGRGRGWGAWGGPWGGHGYGGGRGFGGHERCNSWGRGPFGEGPSHSHGQGEGEDAPRGRSTHRHGDPRARSVSRSSTSSSSSSDSISSSSSSSSSSSSDVDSILSLPSHDDLSPSQLPVARQHLLSFLHHPDQPITRERVRAVREQIRQARYSNPNPSSPLSEENFAVLRAEVKQFLKEWRELVKQQRRKRREERKARRKAKKEERRRKKREKKEAKKARRQARRQERRTRRYGCGGEIPPVGPGDSVSQVGATTGGVGFGAAQVRSAPATPVGREFPRSYPDSPPAPPPPPRPAPDSNPPTGSQAKYALLSDLEIEYAQKHSELEALHVQMVEEVDREEKERQQKRAREVEKEIEALAERIEKVRTEADEEFAREVAAQETAEVVRGRGGGRLLECNIIGGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEM1</accession>
    <name>G0SEM1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Isoamyl alcohol oxidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0064240</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696729.1">
        <property type="nucleotide sequence ID" value="XM_006696666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEM1"/>
    <dbReference type="SMR" id="G0SEM1"/>
    <dbReference type="GeneID" id="18260462"/>
    <dbReference type="KEGG" id="cthr:CTHT_0064240"/>
    <dbReference type="eggNOG" id="ENOG502QUV4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_4_2_1"/>
    <dbReference type="OMA" id="HIGNDNC"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409507" evidence="6">
        <location>
            <begin position="23"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="157"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS18398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="627" mass="68767" checksum="111FEC7CEC9D2EC6" modified="2011-10-19" version="1">MTGFNLRSLTLTTLIAVSGVEATKSKLNPPPQCPYRFAWENVQLSSRDISPFDAFLFGFNTSSKPSLKCKAFPGESSWPSAQTWAKFNKTLGGALIKTVPLAAACYPEWGEYYNPEECQRVRESWTNPRLHVEDPGSGMFPLYQGRSCLPDGGNCTLGGYASYSVAAANVKQIQLAVNFARNANLRLVVKNTGHDFNAKSVGAGALSVWTHKLNDIQFVEDYKCAHSGYRGPAFKLGSGVLTEQVYAAAEKYGVSVVGGECRTVGIAGGFIAGGGHSPLSSLLGMGADQVLSMEVVLPDGRFVTVNERSYPDLFWALRGAGGSTYGIVTSVTVRAYPRIPVSTLTFAYGTSPNVTADTFWESIRVYMKYFDRFATTGAYGYFFVFNIGPDQFLFIMTPFWANNMNSAQLISLVQPYLNDLANLGIEITPNITSYPSVFQAYQGAFPGPETVGTVDNHSGSRLFPKENFQDPRKLNDTLAAVRHAISNGGILVGYNIRSAPNAIANQNNAVNPAWRKARAFFILGATWPANATLAQIQQASKTLTTDWLAKWRAVSPGSGTYMSEADINEPNWQREFYGEYYPRLYSLKKKYDPNGVFYAPTAVGSEDWYVTGQKEWVPSQDGKLCRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEM3</accession>
    <name>G0SEM3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0064260</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696731.1">
        <property type="nucleotide sequence ID" value="XM_006696668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEM3"/>
    <dbReference type="STRING" id="759272.G0SEM3"/>
    <dbReference type="GeneID" id="18260464"/>
    <dbReference type="KEGG" id="cthr:CTHT_0064260"/>
    <dbReference type="eggNOG" id="KOG1812">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004581_1_0_1"/>
    <dbReference type="OMA" id="LAYRDYC"/>
    <dbReference type="OrthoDB" id="1431934at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20336">
        <property type="entry name" value="Rcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26200">
        <property type="entry name" value="Rcat_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="898"/>
            <end position="953"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS18400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1106" mass="123151" checksum="BDB993F85DB5F3E3" modified="2011-10-19" version="1">METTTAYDLLIITDATGSMTSFLRSLNDSIPEIIRLAALTGCFGRIGLLAYRDYEQVLVDRPVIVWSGWYSQRSDLCEIDHDSLLSTAMSLQPISNSQCDFPEASKTALAKAYSVMRPDATTVIILYADAPPHMKNRTVGWQYSNWYEAEQQELQRPDSPYGPSAACFADWIHAGHMLADAKKKAIVFSIIDGPGEALPYYAYLSARTGGTCLKLSRNDSTSISALSVGLIMAWMGATKQCATLSTERLANHIVFEGGKENFELGELGPEDDPRAQSILKDIPRSEITFNPRGRGCGRDGMCPSSTRSRRMWSSTVVTLEALNGIVPRRKPPIVDFSKRYREDEEYRKLVVAELSGIIDSNVLTMALNPVFSSLWRAVCSDRKNPAREELVTRFSQQVDKISNAQQQARMKKWLEESYDFVGEILHTILSVPEDARFPCVFLDPTLRFEPSSLSEDTSTTFTRDELLEIGRSCDARILRRMGRVLTRLTYVDTADALPTHILAAPDKDVPRVPMALASPKYGRKFWRILLHTILPGTMLGSRPAALLAALSLRMGIKPLEQAALEELVHWRDKWNTLDFPETWSLGCLQLLLEADKKAQAAGMPDGVLKDVDRRMFETLVDYKLLEFNLDTKLTARLGWTPNKTKSVLGPIVMCRWCGYSRSVTIMAGDGVCGRCLKLNKQLPVGKTADEYLAIGVSKSYGPETQASWVECSMAECRAQYVVYDIEGLRARPKCHYCRNKGIVSQDDPAYPRLTTAPCVTCSRCLNRVIWPKEYRPADFDAAAYVCPACVTAPDKTIIDEEITPRKLMAENGLSFLLRNDDAVPGDVIFNGRSIFALLSPLSPEQRAALPEKLVVLPALQAESDLTLTINGKPLHNTLPLLRDLNNWISSRSVQTHTCTLCFDSFAPSLLRLACGGRRGCRQPICAGCVDGWYGVNAPGRVINTSALCCPFCRRMPRGNGVLPARVRFLAGLGDAVREKGEWVYGWCRGCGTAKRFAERRCAAGVTDVPEGWLCKECEEQRASEGLVRGKEKEFVVKMCPRCGVATEKVIGCDHITCPCGAHWCFYCGQEKSAEEIYRHMAQEHGGWYNGAPWMEEDVEEEEIFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEY0</accession>
    <name>G0SEY0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Carbon-carbon lyase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0060090</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HpcH/HpaI aldolase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS17996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696327.1">
        <property type="nucleotide sequence ID" value="XM_006696264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEY0"/>
    <dbReference type="STRING" id="759272.G0SEY0"/>
    <dbReference type="GeneID" id="18260047"/>
    <dbReference type="KEGG" id="cthr:CTHT_0060090"/>
    <dbReference type="eggNOG" id="ENOG502QR7H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059964_3_0_1"/>
    <dbReference type="OMA" id="WNRVDDY"/>
    <dbReference type="OrthoDB" id="1621678at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050251">
        <property type="entry name" value="HpcH-HpaI_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502">
        <property type="entry name" value="2-KETO-3-DEOXY-L-RHAMNONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="4">
        <location>
            <begin position="26"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS17996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="266" mass="28073" checksum="005B5CBA861F4045" modified="2011-10-19" version="1">MDASSKMFRSSKLKQVFAEGKRPAFGVWQMLPGANVSRILARSGADWVLVDCEHGNIDDAAMHEAVPAIAALGVSPVVRIPDMQPWMIKRALDSGAHGILIPLIRTVEEVKAVVSAAKFPPQGTRGFGSPIAPQTFEAGLTLTEYLEQANDSLLTMVQIETQEALNAVEAIAPLVDALFVGPFDLGNNIGHPIINGRMDPELDAAIARILKAANAAGKKCGIYCTSGEQAKQYADMGFHMVSVATDYTALSAAVTGALNVASGASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEY8</accession>
    <name>G0SEY8_CHATD</name>
    <protein>
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        <name evidence="3" type="ORF">CTHT_0060170</name>
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    <organism evidence="4">
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        <name type="synonym">Thermochaetoides thermophila</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="759272.G0SEY8"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OMA" id="NMISPSY"/>
    <dbReference type="OrthoDB" id="5413188at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="432"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="414"/>
        </location>
    </feature>
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        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
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        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
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        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <begin position="182"/>
            <end position="192"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS18004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="527" mass="54439" checksum="0A6FD9EDAE0713AC" modified="2011-10-19" version="1">MPPSEIYRPSRREGRSAVTTAPNTENTVVRSDIPSTSHSPSRHNDGQSQPDAEAGGLSRQPSELTMSMSSESWVEVSSRPSSSSLSSIGGDEIVTTGLRVGSGTYPRRRRPQNAMPASFIVGHSDANTSGATSSQDEYEESESEEDRVMTSSNEAIHPTASTNLLSHRRTTSSRNASAAVETDSDSDDDDDGTALGPASSPTPVFRPQPNAFSHPPSHMLNHSSAAASRSSSYPYSQSAPSSRPVHYRSHNNSRRSPPDFLSPSYQADNDAALRASLTTLLSCAAAARSLPKYNTATNTNNNNNNPATISDDERRALGAAILPPTTQPMELRLVPESELMAEHDDGAPPPSGPAAPKAPQQVPSRTGTRTSTGSSPALSPTRLHPSGEKTKRSATVQSARSRGTGRRKASGAVTLERNASQTSFFSSLSPSVLTWAVSAGVVVLVSVVGFGAGYMIGREVGRQEGAAGAASFTAGGGSGGAGLVGNATSAAAAAGSGCGSELVKSSSAGGALKRIRWVGVVGKGVAA</sequence>
</entry>
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                <person name="Devos D.P."/>
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            <dbReference type="PubMed" id="21784248"/>
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        </source>
    </reference>
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            <begin position="17"/>
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    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18091.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="98" mass="10423" checksum="875F8CAF57E424DA" modified="2011-10-19" version="1">MADNMPSPNEYRAGRQGSTASTSSTTSAMSTSGTSGATTTSSTAPPPRRSSKVLFESLQAQKRSNDPAAVARRQSLNEQRPPAGLIGQLWNNWVRGEK</sequence>
</entry>
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    <accession>G0SFT3</accession>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
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                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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    <dbReference type="OrthoDB" id="4359806at2759"/>
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    </dbReference>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="345" mass="39796" checksum="E958E541A1F31F7C" modified="2011-10-19" version="1">MRSILPFFALPLPIHAGINWDVYEYGVVPTFKWSRSFPDDGTDPGGFHVNCRVKRTFHANMYKLKDLPEPPPIGLAPWHDAIEDFLAKREYPGTWDGVDHKGQDREIVMMEWLDVPSRVREWIEEQQRTADPENYKRWMFGVFRKPRYEGEKVYGTVRPKGAQRTAKPAATSTATQAAMTTTETPSADAASTTPGMEAHSPQEQGQTGTSHVHLMEDNIVDVADKDKIVVFAAGSIYEILPLWVSQGSGCESELENLANYRSQAVDHSILAWPIDHTKPRRDLGKRDMQFTIEAMSVTETEDGKRARKMWEKLYRSVRRHERKQLREERLKKRKEIEEERERDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFU0</accession>
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    <reference evidence="3 4" key="1">
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            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
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                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
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                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
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    <dbReference type="GeneID" id="18261250"/>
    <dbReference type="KEGG" id="cthr:CTHT_0072120"/>
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    <dbReference type="HOGENOM" id="CLU_008578_1_0_1"/>
    <dbReference type="OMA" id="GYKVFRP"/>
    <dbReference type="OrthoDB" id="2238745at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:protein-macromolecule adaptor activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF174">
        <property type="entry name" value="ARRESTIN-RELATED TRAFFICKING ADAPTER 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <end position="806"/>
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    </feature>
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    </feature>
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        </location>
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        <location>
            <begin position="987"/>
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        </location>
    </feature>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="677"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="871"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="923"/>
            <end position="933"/>
        </location>
    </feature>
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        <location>
            <begin position="1032"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1071"/>
            <end position="1090"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1170" mass="129396" checksum="12678607F7B2BD89" modified="2011-10-19" version="1">MATRRDHPRFSPFVRHAGGWVSSPPLNVALQLISPQRHLLVADADGCAPRTLSTYTEPDGLLLSGSGLLLDAPEGPFSPFVPGCCPEHDRLRPPPFFQSAHGSVYYSPSRYHEARRQQQQQQRPHSDYFPPPLIEPRQRRPHSIHIISYPSGFVPRELRQPPPGSPERRRQSNRECKKQARKKQKKEEKERSKKQEKRRSLRSLPPGSEKVGRVLSKILAVFAITPKQPSPVSAAPTPRPRPRSCQPRPSSFASFARRFSRNEGVVAIESVLEGDQEVAQTPDMAGPLLHWPYTPAGAFPQNNRNSIISMRSFKTIAGSSVPEAHKPVASGSGISCSILLAEPSVYLTGFDHDHRSRRNGTPASALLRGKLLLNVSKNVKIKSVSLKLVGKARTEWPEGIPPTKTEMFEEQILRSQSLVFFHAMHDGMWDTEYGYRCTYTHRASPTGLLQSLQGNVSQTSLHHLGLGRVPGTLTAKELKRLSLQSVNSRSFGKGESPLTNQVQAKGYKVFRPGTYEYAFELPIDHNQLETANLQYGSVKWELQARIERAGAFKPNLQGSREVLIVRVPDQMSLETTEPISVNRCWDDQLHYDITISGKSFPIGSRIPISFKLTPLAKVQIHKIKIFVTENIEYWTNDRHVTRKDPSRKILLFEKTAGHPIADQYSNCEFRFISGGEPDPKKREEARRRAAARRNKDRERARSSNGKPESLPEVAENLLGPLDLGLEDFWGPTEMEVVVPLPTCEMMERRKELKLHPDCSWKNVNVFHWLKIVLRVSLPDESDSNGRRRKHFEISIDSPFTVLNCRATQANLALPRYSGPDGIPIPEQRPQKSCGCPDAKLLDPSASGAVGALALIEEDILPRRRLRLDTRNIQTRNSVAQNGNRAETITTPPPPPHSAEDDPAPPPLVQVPSYDPPAFDADDPPPPLPNDLLSPPPRYDVIVGTPSVDGLADYFVRLAAYERSRQANGEQGDVSSPKDTATDVLESPAAAILTSAPLAELERGPEGEDGVEERGLSMPMSAPGGGRLAPILETTTQGQGEETGVRVRESEADAVVPATAPSSSRKDSTTLSETVTTQASASESSTTQTPTARARSLPAAVEEDTLSSSDSSAEDDSLDPARPHRMGRVNVANPRTPGGRSVPSRSLDIERPVIRLDLSLSSVLRRRARNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFW9</accession>
    <name>G0SFW9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0072420</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697502.1">
        <property type="nucleotide sequence ID" value="XM_006697439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFW9"/>
    <dbReference type="STRING" id="759272.G0SFW9"/>
    <dbReference type="GeneID" id="18261280"/>
    <dbReference type="KEGG" id="cthr:CTHT_0072420"/>
    <dbReference type="eggNOG" id="ENOG502RA80">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039657_0_0_1"/>
    <dbReference type="OMA" id="EHESRYM"/>
    <dbReference type="OrthoDB" id="5387995at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="491" mass="53169" checksum="D02EBF981BA255A7" modified="2011-10-19" version="1">MGVQLEPLNQGLSEYGPWHFHDIRFQQDQRAELEAALLQTASIPGLNDTLREISRAGRREASSGSTHRDAIIPEVVLSVSKTASRPPSPGPSTGHISPPAETWPSTPPTTPTTPVKSYLPVLPDAPNPYWTFRHLSVPEGPILTFPLERACEPVIRPSLKRRRPDTDVDGPNTASLSCKKRRLLRNLVTSRLSQPFSLPATHIVNRESAATGDKRFAKLAAMMAARRMVTTTLGQQQQMQQPSPSTWLRRAAVLNRLRQRVCAEAAERGGILATADLAAKAAAFRQQGQATATIVGGRYLVQDATPNRLAPGSAVRPATGLPQPTAIPVVVSPVPCSNARPIHPLTTNPSPSSSAQISKQTPPPPPTGPTARLRIPSPQLRPLRSPELRVTRPLVPLELEDLSKLDEGSVQIPACPPSDDTDDDGVAFPTSEHESRYMHDDEEEVGVYADFSVIFGGGGNDIEEEEGEGGDGEHVEDYMDDLDGIPWCARC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G0SG18</accession>
    <name>G0SG18_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="12">3-ketoacyl-CoA thiolase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0064710</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696775.1">
        <property type="nucleotide sequence ID" value="XM_006696712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SG18"/>
    <dbReference type="STRING" id="759272.G0SG18"/>
    <dbReference type="GeneID" id="18260509"/>
    <dbReference type="KEGG" id="cthr:CTHT_0064710"/>
    <dbReference type="eggNOG" id="KOG1389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031026_1_1_1"/>
    <dbReference type="OMA" id="RWCASSM"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF10">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="10">
        <location>
            <begin position="30"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="11">
        <location>
            <begin position="293"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="8">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS17157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="415" mass="44230" checksum="9F068E0DC985DF56" modified="2011-10-19" version="1">MAAERLGSILKHLSPNSAVSKITAKNPDDIVITLAVRTPLCKAKKGGFKDTTLEYMIYALLKEVRERSKLDPALVEDIALGNVSDGKASYKLRAAALAAGFPNTTSCYSLNRFCSSGLKAVADIAHAISNGSIEIGIAMGAESMTIGGDALEKPFDEEVTKHSQESVDCMQPMGWTSENVARDFGVTRQMMDEYAAESFQRAEKAQKAGLFDDEIVPIKTRIKDANGQWQEVTLTKDDGIRYGTTVEALSKIRSAFPQWGPTTTGGNASQVTDGAAAVLLMKRSTAIKLGQPILGKYVGSTVAGLAPRIMGIGPTVAIPKLLAQHNLTLNDIDVIEINEAFASMAVYCRDKLGLDWAKMNPRGGAIALGHPLGATGARQIVTGLSECRKTGKKILLTSMCIGTGMGMAGLFVNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G0SG39</accession>
    <name>G0SG39_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0064930</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696796.1">
        <property type="nucleotide sequence ID" value="XM_006696733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SG39"/>
    <dbReference type="STRING" id="759272.G0SG39"/>
    <dbReference type="GeneID" id="18260531"/>
    <dbReference type="KEGG" id="cthr:CTHT_0064930"/>
    <dbReference type="eggNOG" id="ENOG502QPW5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031888_0_0_1"/>
    <dbReference type="OMA" id="YMEVLYP"/>
    <dbReference type="OrthoDB" id="5307821at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024752">
        <property type="entry name" value="Myb/SANT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46929">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46929:SF3">
        <property type="entry name" value="MYB_SANT-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12776">
        <property type="entry name" value="Myb_DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like" evidence="2">
        <location>
            <begin position="32"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="464" mass="51228" checksum="F8253916F62CD812" modified="2011-10-19" version="1">MSNESFANNNAQANGNGATTTTKGKHRGPRFTWNSAYEATFFRSLCESVACGLRDGSTFKPEAWDRAIRALIENHNAYANKAHLINKTDNARKKYRLWRGLREDPEFYYNPQTRTVSASEEAWMRHLQKEPLARSLRARPFEHEEYYEILFPDVIGSGGAPKRVTKKKKQQQQDQQQQDQQQNGVESSVEPEQQQQPAAIMDLVPSQAYIDPTQTHLAAAIPQTLTSPMTAHVAQIQQHAHPANGRPALPPAPTASALTPPEDTAAATAQTTAATSAMQTRKRTQAPDNAASNQHADKRRRTGQPMQNGGFGDLTQQQQLPVATSSGANAMPTAPTLPSQANHASPSHAAPSPSSNTTTSPAITEALHLLTEAIRLVATSTHPLPPAPNSRLSRLPTLSGHPSWQERAMDIFFAEFSNEDNDLQLKIAEKVLADETKAMVFCKMPDALRRHWVKRLRELHNRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G0SG53</accession>
    <name>G0SG53_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase DED1</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP-dependent RNA helicase ded1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CTHT_0065070</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696810.1">
        <property type="nucleotide sequence ID" value="XM_006696747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SG53"/>
    <dbReference type="STRING" id="759272.G0SG53"/>
    <dbReference type="GeneID" id="18260545"/>
    <dbReference type="KEGG" id="cthr:CTHT_0065070"/>
    <dbReference type="eggNOG" id="KOG0335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_16_3_1"/>
    <dbReference type="OMA" id="CYRSWVR"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17967">
        <property type="entry name" value="DEADc_DDX3_DDX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000160">
        <property type="entry name" value="ATP-dependent RNA helicase DDX3X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044763">
        <property type="entry name" value="Ded1/Dbp1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="19">
        <location>
            <begin position="179"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="210"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="411"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="126"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="574"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="14">
        <location>
            <begin position="179"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="576"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGS17192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="658" mass="70721" checksum="23648A445C743266" modified="2011-10-19" version="1">MAEQLSNGMNKLSLDSQAPAAPAQQPAVRSYIPPHLRAKMAQQQQQQQAGANGSATTPSVGGGPSSTMSGLNNSAWANNNNYDSGRNWGNYDSWNSRGGGFNRNAYRGPGGGGMGGGFGRGEGRWVDGKHLIGNPDPRLERELFGSADDPSKQHTGINFEKYDDIPVTPSGRDVPEPVLTFSNPPLDPHLLSNIELARYKIPTPVQKYSIPIVINGRDLMACAQTGSGKTGGFLFPILHLSFTQGPSPVPAQPGGYGRQRKAYPTALILAPTRELVSQIYDEARKFAYRSWVRPCVVYGGADIGSQLRQIERGCDLLVATPGRLVDLIERGRISLCNIKYLVLDEADRMLDMGFEPQIRRIVQGEDMPPTGKRQTLMFSATFPRDIQMLAQDFLHDYIFLSVGRVGSTSENITQKIEYVEDIDKRSVLLDILHTHTGGLTLIFVETKRMADSLCDFLINQNFPATSIHGDRTQRERERALELFRNGKCPILVATAVAARGLDIPNVTHVINYDLPTDIDDYVHRIGRTGRAGNTGIATAFFNRGNRGIVRELIDLLKEANQEIPSFLETIARESSYGGGRGGRGGGGGRGRGRGGQTDFRKYGGGGGGFGGPSHSSGGYGGGYGGGYGGPPSGGYGGYGGGYGGGYGNPGGSGGQSWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G0SG80</accession>
    <name>G0SG80_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CTHT_0065370</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the RBR family. RNF14 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="3"/>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696837.1">
        <property type="nucleotide sequence ID" value="XM_006696774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SG80"/>
    <dbReference type="STRING" id="759272.G0SG80"/>
    <dbReference type="GeneID" id="18260575"/>
    <dbReference type="KEGG" id="cthr:CTHT_0065370"/>
    <dbReference type="eggNOG" id="KOG1814">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021364_3_0_1"/>
    <dbReference type="OMA" id="PRSWCQG"/>
    <dbReference type="OrthoDB" id="1431934at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20341">
        <property type="entry name" value="BRcat_RBR_RNF14"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rcat_RBR_RNF14"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RING-HC_ITT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RWD_RNF14"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
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    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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        <property type="entry name" value="Znf_RING_CS"/>
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        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RWD" evidence="14">
        <location>
            <begin position="11"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="178"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="182"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="517"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="517"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGS17219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="636" mass="71140" checksum="7DD9286985119CCF" modified="2011-10-19" version="1">MATDPESQRDIELSSLEAIYPEIQHPVPDNPYTFVLALPITPPKPVTVFSRRPDSDLASQAHTDAGHSQEVVHLPALRLEVSLGPNYPETEPPKVTISAQPAWVPQDKLSQLEAEVSNLWESLGRDMVVFSFIDHVQQAADEVFGLINEKGVLEVDSGLMIALLDYDFEARRAAFAKETFDCGICLEPKKGSVCHRMLDCGHVFCVQCLQDFYNAAIKEGDIAAVRCLEPGCAKERANAVSDKRRKKQAESVSPSELLQIPLDKDVVKRYVDLKYKIALETDKNTVYCPRSWCNGAARSKRHKKPQGLELPEASDDEDNEESEEDDERLAICVDCNFAFCKRCKKSWHGPFVYCKRTVEEKNQGQTIEDLATLEYIRRYTSPCPSCDAPVQKTAGCNHMRCSRCDTHFCYLCSAWLEPSNPYRHFNGGSPYCTGRLWELEAGQEAWDVDIERDLQGGPATDPNRDPFATHVFNYDQPEQRAAALDDARFDMRAAIMDFVGFDDDEVLGMQAALVPPAEQPAAAGAQQQDEAEQAHGLPEDPGQLRLRPTQSGVLLLRLLLLRGEENEDGDRLIDLLAEVAQPLVSDEQQQQDREEEGIIIGPLVEEEQMLRGVDVQELELPVVAELGLFLIIKDIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGK2</accession>
    <name>G0SGK2_CHATD</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0066630</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006696896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGK2"/>
    <dbReference type="GeneID" id="18260701"/>
    <dbReference type="KEGG" id="cthr:CTHT_0066630"/>
    <dbReference type="eggNOG" id="ENOG502SYM1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031222_2_1_1"/>
    <dbReference type="OMA" id="EHYYLAN"/>
    <dbReference type="OrthoDB" id="5426678at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409145" evidence="3">
        <location>
            <begin position="26"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
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        <location>
            <begin position="414"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="373"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS17341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="530" mass="55454" checksum="A86D64E479714098" modified="2011-10-19" version="1">MARQQTTVTAVLTLVTLFSNSPSRALQVSPNSPCARECLDAPHLDVSDPNSSSTLNSDIVCQDADYNSNTGTKFMSCMSCLQKSSFAQGSESDVKWFLSYSYCSAGNGEAMDPANFDSCIQCISAEHRTDYLANSGCEQQPAPGTGILGLNGTVFTKGQIQIVDPSTLEDDGGSEGPVLPTSTIIGIAAGSVALLLLLAAVTFVCVRRRQNKRTREIKSRRHTSSLSFQCQTHILSPRFWPGVNNPGSQGFPQPDSSSGVWQAPQHVDEALTSGNSVHDDIETASTATTATTKKHGLASLPSLHHLTTTVPPPPSPPPQAHTSTSPSSDFNSPLSATESVRSTSPLLPPPPPGIRKYNPAEYGVLNNSPLSPPSGSSSTFSSPISTSGMGFGLALSSPGSRLDNGSVAGWTDQRLYHAPSPAPPRIQTPSQSPGLGVFENPAVPEKMSERKTTPPPARPASSDGVKSGGGSVFLPPPPPTLPTLKTSRSSGLLTAASGVMLKKKGSGSPMPGSPVESVEIKTKFEGPPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGL0</accession>
    <name>G0SGL0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0066710</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696967.1">
        <property type="nucleotide sequence ID" value="XM_006696904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGL0"/>
    <dbReference type="GeneID" id="18260709"/>
    <dbReference type="KEGG" id="cthr:CTHT_0066710"/>
    <dbReference type="eggNOG" id="ENOG502RZ22">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014887_0_0_1"/>
    <dbReference type="OMA" id="TWTGMEE"/>
    <dbReference type="OrthoDB" id="3045089at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054464">
        <property type="entry name" value="ULD_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34465">
        <property type="entry name" value="CARBOXYL-TERMINAL HYDROLASE-LIKE PROTEIN, PUTATIVE (DUF627 AND DUF629)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34465:SF4">
        <property type="entry name" value="CARBOXYL-TERMINAL HYDROLASE-LIKE PROTEIN, PUTATIVE (DUF627 AND DUF629)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22893">
        <property type="entry name" value="ULD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="658"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="796"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="816"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="869" mass="100004" checksum="C485B256FF90A350" modified="2011-10-19" version="1">MSHSEDSYSEEESRTASQYSDEQSLADDDDEEEEEEEESTEQEDSDQESSNYSSSRYDHSDSASTGYGSYYGRRQVARRTQTPTREHRGPARRHQLPAHQADPFQYQVTQEPMSDSYDDDYYSAYGHRGYPPPVPHTQGAFYNHNSRHSYAPSHSGYGYSGQMIPYGDPYQRDYHRGYQRGAYEDPYGADPRRSGVPYYGDPRGHHPYDLMHYGSQAINPYYGPGGPGPFGMPGHLQHYMYNAPPPPPTEVGDRSTPKPEKEKKKKEVELPPEVLEMKKQLEAQMQALKLKEEEERKRKEEEELKERARKEAEEKLRQELERQKQEEERRKKEEEERRLELERLRLEAQQQALARLEEERKAAEEARKRQEEEMARLQREAREKLEAEIRAAEERRRQEEETRKRLEEEARRKLEAELRAAEERKKREAEAAALAEAQARARLEQALREERERLQAELKAEEKRKQEAAQRAAEEAERLKRIEEEHQRKLEAAMKEQQAKLEAAIREEREKMEAARRAEEEAKAAAARKAAEEAEKLKRIEEEHQRRLEAAMKEQQLKLEAALREEREKLEAARKAEEEAKAAAAAAAAAEAERIARIEAEAKAKAEKETLERIEREKREEEERRKAEEERKKAEAAERKRIEEETKKKLEEEKKQEEKPPIKFKDAIGRKFEFPWNIACTWQGMEDLIKQAFLHIEPIGPAVQEGHYDLIGPNGEVILPMVWDKVVQPDWQITMVMWPTEKARVQQPGPPVPPGITPAQVQAQAQAQAVNGQRTGHHHHRATSVPGISTTFVRPNGTAPRPPQPPAGWTPAMGGMPPPPPPPPGMPPVARPNIVDVVPPAKAKEKKIKPSPVLGWMAGAKPVAKPTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHC0</accession>
    <name>G0SHC0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative metal ion transmembrane transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0069480</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697227.1">
        <property type="nucleotide sequence ID" value="XM_006697164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHC0"/>
    <dbReference type="STRING" id="759272.G0SHC0"/>
    <dbReference type="GeneID" id="18260986"/>
    <dbReference type="KEGG" id="cthr:CTHT_0069480"/>
    <dbReference type="eggNOG" id="KOG2474">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023518_1_0_1"/>
    <dbReference type="OMA" id="HVVDCAH"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF210">
        <property type="entry name" value="ZINC-REGULATED TRANSPORTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="163"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="266"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="193"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS17609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="493" mass="53494" checksum="B2ECD4A6FDD6A7DD" modified="2011-10-19" version="1">MEIDNDTRGWILCAFSGVACVLGAAITCIDYFVRLLPGKRNFRIQQSSAFLACSLSLSFGVMLFSALYSMLPSAMRYLTEDGWDHQSAGFLMMTCFVTGYFGIKMMSRVLHQYMPSHVVDCDHTHQGPVDVEVGHHHGQRDEHTYPRPSIAETTPLLSARTDGAANGAAKLKSPRTLSVTSKSNGHPQTNGHPHPDVHPHDADNTDRRPSARHSKSLVMCLLKDTPDCSEEGPCFGYSDPCNQSCFKHTGGPLTRSVTLPASFCSPSHDDVPRESFHENPAHSPDESTLAPDSEPGPIIHTPDVYSHSPDAHSHHSHHSSQQQQQQQQHHHHVPTNAFLSISLQTVLAIALHKFPEGFITYATNHANPTLGLNVFLALSVHNITEGFAMALPLYLALNSRVKAIAWAALLGGLSQPLGAGVAVLWFTLAGDKQVGVNNTAYGCLFAGTAGIMVSVALQLFVESLGLKHDREMSILFGFGGMMLMGVSNALVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHT3</accession>
    <name>G0SHT3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0073280</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697585.1">
        <property type="nucleotide sequence ID" value="XM_006697522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHT3"/>
    <dbReference type="SMR" id="G0SHT3"/>
    <dbReference type="STRING" id="759272.G0SHT3"/>
    <dbReference type="GeneID" id="18261366"/>
    <dbReference type="KEGG" id="cthr:CTHT_0073280"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006468_3_0_1"/>
    <dbReference type="OMA" id="NAYAVYT"/>
    <dbReference type="OrthoDB" id="442677at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="354"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="23"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="478"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="533"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="571"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="50"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="537"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="571"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="597"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS17003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="623" mass="68272" checksum="B03473F8C0409F71" modified="2011-10-19" version="1">MTKDKPALLLSAKAIDPALDALFSQSAGPVQPPPKTRYAELARKARQESEEKEEEKELEDVESEEEEDASENGEESSEVGSGDEEESEVSEGESDEEDVEDEGENESEPESEADNDDASESASAEEELVTPKAIEEAVLNGTTKEEGRKRKRKLRDEDENLEAAYLERLAREEKEEEERSAKRQKAVDGASLPKEIDEKKADGEADDKSSSGEIPVHEALQPGGTSEIQSELDKANRTVFLSNVSVEAIKDRKAKKILLKHLASPLDKKADPPQKIESIRFRSTPFGTTKIPRRVAYIKKEIMEGTTKSTNAYVVYSTAAAARLAVQHLNGTIVLDRHLRADSVAHPAPIDNRRCVFVGNLGFVDDESVYRTKVEDGKLVTEKKKKGKEPSDVEEGLWRVFGEHAGKVESVRVVRDPATRVGKGFAYVQFYDPNSVESALLLNGKSFPPLLPRELRVSRCKPPHKTARAIEAKQAKAALAAAEAKRKGKKGKGDDEPPTSAQYNPKLSAEAQTLAGRASKLLGKYNAERLVGVPAGKKSKKKEKKTKKAALDPEGAKALAAAVGVAEGKPVKTPEEFVFEGKRASAKDGKPRDLKFRPKKKAKDKVHGSKKSKKEKKKKAGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHT9</accession>
    <name>G0SHT9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0073340</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697591.1">
        <property type="nucleotide sequence ID" value="XM_006697528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHT9"/>
    <dbReference type="STRING" id="759272.G0SHT9"/>
    <dbReference type="GeneID" id="18261372"/>
    <dbReference type="KEGG" id="cthr:CTHT_0073340"/>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003954_1_0_1"/>
    <dbReference type="OMA" id="HGRIQQP"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045033">
        <property type="term" value="P:peroxisome inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000011">
        <property type="term" value="P:vacuole inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000397">
        <property type="entry name" value="Serine/threonine-protein kinase KIN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="194"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="153"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="486"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="560"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="49"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="486"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="562"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="578"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="597"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="615"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="668"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="750"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="816"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="872"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="932"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="954"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="976"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1027"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS17009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1063" mass="116918" checksum="51ADA3D4BBB183BB" modified="2011-10-19" version="1">MTSRAAVAPPVPVPVSPVADSPDHLGSPDRRRTMPAVVPPRTSSTRRAQPTDRPVDSPRRTNQDSSRDTNGRIDPSDPSRSRRTYQDPYSPNGRGNTSAAAYSRSPPADTHFGNGPSRDASEILNNFLDSQHEARSEKERMALIQAHQQAPLYDDDAAPPPIVSHADHGEEPRRGARSRHDHSKKEKPTRFGEYILGNTIGEGEFGKVKLGWKADTGHQVAIKLIKKDQLGNNPARMAKIMREVAILKQLTHPNIVKLHKMEESERHYGIVLEYASGGELFDYILNHRYLKDNAARRLFAQLISGVGYLHKKGIVHRDLKLENLLLDRNRNIIITDFGFANTFDPNDELTEEEEMNLSDKEFVKRMGLDKIKPNAPELVVSDSLYTGRKVDVWSCGVILYAMLAGYLPFDDDPANPEGDNINLLYKYIVNTPLTFPDYVTPHARDLLRRILVPNPRKRADLFEVARHSWLSEYAHVVEFITSSTTTPKDIQNTTVPPEDFDETPTIARSASVRESSKKAPVTSSIGGLATKQGTVDVDSDAAYTRQQRDNKRRTVQVEYVAPSTNTQRGESSGAQPFSSRTGSRSASQSTAPAPTRDPTREKPTPSQPVKEDFSKSTSTRVPQSSQQRAGGSVVAVRTTQPARSAPEPAPAPASLLQNLSHTPADGPPTSSSISSNNANKRASYSQPAAPELNDANVEGRIEQPPKTSNYGIPSPTPHSQSDHPRPGLSSVPPKFIQLSGFNNREGETPTPGSVGTTQGSSEVKGHKRSNTMSEISGKLFGRSGSIFGGKNRKKEQSGEKTKKYPPISMNNSMPGGDEHSRTSLDSRRSRRSFSIGIGKKTSGSITSSQEKKGRRFSFLPYLSKGGKEERSQSQLDSQQDLPIQEPPTPSQSGQLVDQNIGREHAEATTLDNMYTQLHDPRYSPSPYDRRQSYQPSSSYGRPSASDTLMPPPLLNTSDASFDSTNLRRPAGTGSAPQLPYPSGLQPPQQQSQPLQQPRPNQSDNDVRTPTVGTPTSSKRGVLQKPKRFTDAYDAHHDHSGSSGPARRVMDFFRRRAKARAGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0SI69</accession>
    <name>G0SI69_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0074710</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697721.1">
        <property type="nucleotide sequence ID" value="XM_006697658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SI69"/>
    <dbReference type="GeneID" id="18261509"/>
    <dbReference type="KEGG" id="cthr:CTHT_0074710"/>
    <dbReference type="eggNOG" id="ENOG502SP0C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_3_0_1"/>
    <dbReference type="OMA" id="FRLTEGW"/>
    <dbReference type="OrthoDB" id="5417887at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF42">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="53"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS17139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="380" mass="42332" checksum="98F4D74326EF43CF" modified="2011-10-19" version="1">MASVDNTSRPEQYAAPVDVDPNQLAALPHDDSGPKLNAVIWTLTALSGLILALRIYCRFWRRKGLWWDDAFLIAAWLCITVESAMLTKATTLDYGKHIWDFDMANMRELLLYINIAGSFSVTAAIWAKTSFGITLLHLTDGWIKMVTWVIIISMNIAMGLSALFPWVNCKPLKKSWDYTIDGTCWAHEVTVHYNIFSGAYSTFMDFALALLPWGFIWKLQMRKKEKFGVGVAMSMGILAGITGIVKVSKIPNMLSNDFADGVDLWCWGNAETTVTIIAASIPMLRVIIREAAGSRQTYGAEYYKEGMTTGKRNVTGNVTISRGGPMGSDVEMAKQINDDSSSDKGILDNSNQDTFKMGRIVKTHNFTIEYHSRDSHQGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0RXZ3</accession>
    <name>G0RXZ3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Brix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0004820</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="9 10 11" key="2">
        <citation type="journal article" date="2023" name="EMBO Rep." volume="24" first="e56910" last="e56910">
            <title>Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation during pre-60S biogenesis.</title>
            <authorList>
                <person name="Lau B."/>
                <person name="Huang Z."/>
                <person name="Kellner N."/>
                <person name="Niu S."/>
                <person name="Berninghausen O."/>
                <person name="Beckmann R."/>
                <person name="Hurt E."/>
                <person name="Cheng J."/>
            </authorList>
            <dbReference type="PubMed" id="37129998"/>
            <dbReference type="DOI" id="10.15252/embr.202356910"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BRX1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691021.1">
        <property type="nucleotide sequence ID" value="XM_006690958.1"/>
    </dbReference>
    <dbReference type="PDB" id="8I9P">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="CA=1-316"/>
    </dbReference>
    <dbReference type="PDB" id="8I9R">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="CA=1-316"/>
    </dbReference>
    <dbReference type="PDB" id="8I9T">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.60 A"/>
        <property type="chains" value="CA=1-316"/>
    </dbReference>
    <dbReference type="PDB" id="8I9V">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="CA=1-316"/>
    </dbReference>
    <dbReference type="PDB" id="8I9W">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="CA=1-316"/>
    </dbReference>
    <dbReference type="PDB" id="8I9X">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="CA=1-316"/>
    </dbReference>
    <dbReference type="PDB" id="8I9Y">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="CA=1-316"/>
    </dbReference>
    <dbReference type="PDB" id="8I9Z">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="CA=1-316"/>
    </dbReference>
    <dbReference type="PDB" id="8IA0">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="CA=1-316"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RXZ3"/>
    <dbReference type="EMDB" id="EMD-35279"/>
    <dbReference type="EMDB" id="EMD-35281"/>
    <dbReference type="EMDB" id="EMD-35283"/>
    <dbReference type="EMDB" id="EMD-35285"/>
    <dbReference type="EMDB" id="EMD-35286"/>
    <dbReference type="EMDB" id="EMD-35287"/>
    <dbReference type="EMDB" id="EMD-35288"/>
    <dbReference type="EMDB" id="EMD-35289"/>
    <dbReference type="EMDB" id="EMD-35290"/>
    <dbReference type="SMR" id="G0RXZ3"/>
    <dbReference type="STRING" id="759272.G0RXZ3"/>
    <dbReference type="GeneID" id="18254520"/>
    <dbReference type="KEGG" id="cthr:CTHT_0004820"/>
    <dbReference type="eggNOG" id="KOG2971">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048373_2_1_1"/>
    <dbReference type="OMA" id="YRHRHLM"/>
    <dbReference type="OrthoDB" id="1638493at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000009">
        <property type="entry name" value="Ribosome biogenesis protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026532">
        <property type="entry name" value="BRX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRX1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9 10 11" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Brix" evidence="6">
        <location>
            <begin position="34"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="202"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="278"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="301"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS23779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="8I9P"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="8I9R"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="8I9T"/>
        </source>
    </evidence>
    <sequence length="316" mass="36413" checksum="1CA72D37436A9AD4" modified="2011-10-19" version="1">MAAVYKTIAKVTGSKEDKDKEDRSNIIAERKNKQRVLVLSSRGVTYRHRHLLNDLASMLPHGRKDAKFDTKSRLYELCELAELYNCNNVLFFEARKGKDLYMWFSKVPNGPTVKFYAQNLHTMEELHFQGNCLKGSRPILSFDAAFEQEPYLKVIKELFLHTFGVPQGHKKSKPFIDHVLSFSVADGKIWVRNYEIREVEKVKGEADKREEGETEKPKAAKPGSKDTDINLIEIGPRFVLTPIIIQEGSFGGPILYENKRFISPNKIRAELRKAKAARHHARMEQQRDLLARKRQLGLDESTPKKKDDLDTRELFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0RY13</accession>
    <name>G0RY13_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endopeptidase inhibitor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0005030</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I9 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691041.1">
        <property type="nucleotide sequence ID" value="XM_006690978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RY13"/>
    <dbReference type="GeneID" id="18254541"/>
    <dbReference type="KEGG" id="cthr:CTHT_0005030"/>
    <dbReference type="eggNOG" id="ENOG502SC39">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_156026_0_0_1"/>
    <dbReference type="OMA" id="SAIVWFE"/>
    <dbReference type="OrthoDB" id="3888684at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.80:FF:000005">
        <property type="entry name" value="Proteinase inhibitor I2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052471">
        <property type="entry name" value="PBI_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28288:SF1">
        <property type="entry name" value="INHIBITOR I9 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28288">
        <property type="entry name" value="PROTEASE B INHIBITOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003409132" evidence="2">
        <location>
            <begin position="20"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS23799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="98" mass="10210" checksum="17602F0CD675FC60" modified="2011-10-19" version="1">MKPITAITAALALLSGAAALDIQKSVIISYPPETPDSVMTQAKKAVIDAGGIITHEYKMIKGFAAKVGEKVLETVSAMGAKYQVLVEEDVEVHAVGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G0RYQ7</accession>
    <name>G0RYQ7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative inorganic phosphate transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0007540</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS24043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691285.1">
        <property type="nucleotide sequence ID" value="XM_006691222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RYQ7"/>
    <dbReference type="STRING" id="759272.G0RYQ7"/>
    <dbReference type="GeneID" id="18254792"/>
    <dbReference type="KEGG" id="cthr:CTHT_0007540"/>
    <dbReference type="eggNOG" id="KOG4554">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099163_0_0_1"/>
    <dbReference type="OMA" id="ITYSEYD"/>
    <dbReference type="OrthoDB" id="18139at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012098">
        <property type="entry name" value="SND3_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112:SF1">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10032">
        <property type="entry name" value="Pho88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008756">
        <property type="entry name" value="P_tr_PHO88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS24043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="191" mass="20923" checksum="0984274F38AAB943" modified="2011-10-19" version="1">MALSPQITNLIIIFGMMQVSKKIPFDDPNVLNMCRAAYLASNLIILCISLYIKSVVDKKKDMTTLKYIEPAPPGSSEEGKLVTTTVHAYDVEQVKILIKSQLFGIGMMAFMHLYLKYTNPLLIQSIIPLKGALESNMAKIHLWGMPATGDLKRPFKQPGGLLGGLFGQSVQADKKAVEAAERAGRGGVKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZ76</accession>
    <name>G0RZ76_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0001980</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690746.1">
        <property type="nucleotide sequence ID" value="XM_006690683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZ76"/>
    <dbReference type="STRING" id="759272.G0RZ76"/>
    <dbReference type="GeneID" id="18254236"/>
    <dbReference type="KEGG" id="cthr:CTHT_0001980"/>
    <dbReference type="eggNOG" id="ENOG502SH73">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007091_1_0_1"/>
    <dbReference type="OMA" id="VYNQEMR"/>
    <dbReference type="OrthoDB" id="4236860at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF130">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTO (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="92"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="193"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="512"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="793"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="17"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="795"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS23504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="910" mass="103330" checksum="7C7759E18BF2019B" modified="2011-10-19" version="1">MSEPSEHSTSPAATESHLSHHDSHSSHVDRDHDHHDRESSHNDRDRDRDRDHDRDRNRTGSVSGNDRDRGAGGSADRSDRPPPRKRQRVRLSCLECRRRKLSCDREFPCSRCLQSGTPERCEYETRPGLAPPNKLGLTPTALAGIESRLPPLSLPSTGGESPYFRKDARDSDRIRRLELEVAQLKSLLLKQAQAPSVDGSSTLQERSPQEVKQANDEQTEQEQRREVEVPPFLQTQETSADREELRFFRGKEFKTRYYGPASAFLAFQELSGLCPFMKETSEEWLRPLHIHRPKDRKKGAEERERRFREPDPELEALLPSKEETDNLVSIYLEQFEQVHRIVHIPSFRRDYAKFWQPGETRNAAFTALVLAMMGISSCLGAQLPHKFDKMVSSSHTRAIRWVQAVDAWQEKQSQKHRRLIHYQIACLVYLAKRINTMKKKRFWKNAGAMTQDAIGVGLHREPSHMSDKISPFNQEMRRRIWATIQSYDLQASFDHGLPSILCSLHFDVDPPRNIDDEEFDEDSKELPPSKPPSEYTFSSFQHLSRQSLPLRLELSRLLTGPPEELDYDRVIRYTNEINQEIDALPSWDVSDTSTDSSQSDQQGRPLKKPLLAYTLLHIQLRQYIIPLHQPFLRLRKTNSKYQYSEIIYYNAARDMVLLHDRLAQQGIRTLNFLREDSLTLAINLTSVTMLQPRGSTNMIMINSQHTLQLLEKCLAMKEDRILRCGNNEPWGYSIMCAAFGLLEAHLGTKTPEAAKAASAERFINLHYKLLAGQDPPGSQQSLGLGVAGCCSGVPQGSAPSDQQQHQQQGRGMPGMPYGPQLPNGSAGEGGYMRSKSVTPFPPSSSQQGAVGGANQVEVPGTPWWMPNAADPSGLPQQIQPLNPEFNLETLGYNLNELWGSGNFDWDAMMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZ90</accession>
    <name>G0RZ90_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0002120</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690760.1">
        <property type="nucleotide sequence ID" value="XM_006690697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZ90"/>
    <dbReference type="GeneID" id="18254250"/>
    <dbReference type="KEGG" id="cthr:CTHT_0002120"/>
    <dbReference type="HOGENOM" id="CLU_1454221_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="186" mass="20019" checksum="9A44033366E06D97" modified="2011-10-19" version="1">MPDEKQEQREQDKGKASAVASTSNASKNQTADHRRIPVLKPLELFMAFTIGKKLSVSDPANNAPQKQPSSESLLSLAAFLSTTEPPALKPMVPLVTASAVRTSFLPPLDLGGTEIEISPAPAIPKFWLEASNSRVVGSTRNQDTNDNTEDPDDVIPPPLPLRPKAKANRTSLFVGLKRGSMAIILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZJ0</accession>
    <name>G0RZJ0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative pyridoxal phosphate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0003130</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690860.1">
        <property type="nucleotide sequence ID" value="XM_006690797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZJ0"/>
    <dbReference type="STRING" id="759272.G0RZJ0"/>
    <dbReference type="GeneID" id="18254351"/>
    <dbReference type="KEGG" id="cthr:CTHT_0003130"/>
    <dbReference type="eggNOG" id="KOG0053">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018986_3_0_1"/>
    <dbReference type="OMA" id="HKKMHGV"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000072">
        <property type="entry name" value="Putative cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000066">
        <property type="entry name" value="Putative cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF35">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE (AFU_ORTHOLOGUE AFUA_7G01590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS23618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="420" mass="46338" checksum="9FFF8097A1AE1939" modified="2011-10-19" version="1">MAPNINDAAAKLPAAFNKKLSLASRSVHADDHINKNPDVAPPMHVSTTYRYAANPDDLVPWSEIDESNFWTEQAASHDPFWIYSREKSPTSTRFETILTSLLGAPAVSYASGLAAFHAMMVFLNPRRVAIGGGYHGCHGILKLLNKLNGLQVVELEDEAALAALQKGDVIHVETPLNPYGEARNLAYFRQRADELGCYLTVDATFAPPPLQDPFQFGADIVMHSGTKYFGGHSDMLAGVLAVRPDRASDWLGTLLEERLVLGSVMGSLEGWLGVRSLRTLELRVTRQSETAQKLVDWIAAEKAKEGSVVADVVLEVRHASQQPEAKDENSWLRKQMPRGFGPVFSLVLKSEQHARRLPSKLGLFHHATSLGGVESLIEWRAMSDSSVDRRLVRVSIGVEGFEDLRDDLLQGLQALREELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZL3</accession>
    <name>G0RZL3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0003360</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Subunit b, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 10">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. In yeast, the dimeric form of ATP synthase consists of 17 polypeptides: alpha, beta, gamma, delta, epsilon, 4 (B), 5 (OSCP), 6 (A), 8, 9 (C), d, E (Tim11), f, g, h, i/j and k.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the eukaryotic ATPase B chain family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988032">
        <property type="protein sequence ID" value="EGS23641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690883.1">
        <property type="nucleotide sequence ID" value="XM_006690820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZL3"/>
    <dbReference type="STRING" id="759272.G0RZL3"/>
    <dbReference type="GeneID" id="18254374"/>
    <dbReference type="KEGG" id="cthr:CTHT_0003360"/>
    <dbReference type="eggNOG" id="KOG3976">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077208_0_0_1"/>
    <dbReference type="OMA" id="YTEWADG"/>
    <dbReference type="OrthoDB" id="67388at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2210:FF:000002">
        <property type="entry name" value="ATP synthase subunit 4 mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008688">
        <property type="entry name" value="ATP_synth_Bsub_B/MI25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013837">
        <property type="entry name" value="ATP_synth_F0_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12733:SF3">
        <property type="entry name" value="ATP SYNTHASE F(0) COMPLEX SUBUNIT B1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12733">
        <property type="entry name" value="MITOCHONDRIAL ATP SYNTHASE B CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05405">
        <property type="entry name" value="Mt_ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161060">
        <property type="entry name" value="ATP synthase B chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0138">CF(0)</keyword>
    <keyword evidence="4 10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS23641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="247" mass="27206" checksum="9D25F52BA4F8864D" modified="2011-10-19" version="1">MASRLARSAVGAARLRPTISPRTLPAVSSLVTARNQSTQSNVPTTDPKTKAQSIIDALPGSNLLSKTAILSSAAGLSIYALSNEYYVVNEETVIAFCLLSVWTGLIKYGGPLYKEWAESQNNKIKNILNAARADHTQAVKNRIEDVKQMSEVVEITKSLFEVSKETARLEAEAYELEQRTALAAEAKNVLDSWVRYESQVKQRQQKELAEAVIAKVKKELENPKALDKILQQSVADVERIFASSKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G0RZX0</accession>
    <name>G0RZX0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0007920</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691322.1">
        <property type="nucleotide sequence ID" value="XM_006691259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0RZX0"/>
    <dbReference type="STRING" id="759272.G0RZX0"/>
    <dbReference type="GeneID" id="18254830"/>
    <dbReference type="KEGG" id="cthr:CTHT_0007920"/>
    <dbReference type="eggNOG" id="KOG0616">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_5_1"/>
    <dbReference type="OMA" id="CFDDYPE"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000210">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF37">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="65"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="12">
        <location>
            <begin position="345"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS23131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="402" mass="45764" checksum="BC34E77E8D63EF8D" modified="2011-10-19" version="1">MATVIQAQPLPPGGGLHPLQAKALMAAQQQQQQQQQQQQQQGQPPQKDANEEPFDPSRKLTAHDFVRVRTLGTGTFARVCLVRPSHGSEADRSKVYALKILRKTDVIRLKQIDHVRSERQILADVRGHPFVADLVASFSDATTLYLLLTYVPGGELFTYLRRFRRFDEDTARFYAAEIVLVLEFLHEQCGGVAFRDLKPENLLLDEQGHIKLVDFGFAKRLTNESSGANNGELTETYTLCGTPEYLAPEVIQNKGHTTAVDWWALGILIFEFLTGYPPFWHQNPLEIYKQIIEKPITTVLPQSPPLSVSAQDIITQLCNVDRSRRLGNVSGGAARVKAHPFFADHNVDWDALYHRRVRAPIIPPVRYPGDARCYDIYPEEDAIKEEYTEEMREKYDEFFKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0S069</accession>
    <name>G0S069_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0008940</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691421.1">
        <property type="nucleotide sequence ID" value="XM_006691358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S069"/>
    <dbReference type="STRING" id="759272.G0S069"/>
    <dbReference type="GeneID" id="18254932"/>
    <dbReference type="KEGG" id="cthr:CTHT_0008940"/>
    <dbReference type="eggNOG" id="KOG2084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018406_5_3_1"/>
    <dbReference type="OMA" id="CKIQNNS"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="71"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS23230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="459" mass="51299" checksum="5C0DC2AEBBEF5737" modified="2011-10-19" version="1">MFGRVQQRAGKDWLPTPVRALAQVLIRLKAGDQAVAETFGSLAWAKGASDGERGILDGNVEGFKKHDQVWKDFEIQATGAVVYAGLENDFSIPRAREILCKIQTNAFNRLDPDAGMTGIYLDPVLAMANHSCMPSAFVSFDQRNAVLRAWRDIKEGDEITICYVDVTLPNKAARQEALKLYHFECRCPRCKDDLDVYQACQIDPALPLNSLSIQPDLEKLRNPPIDRSKVSKEQLDAIYEAWKTLPTTEGRSEAEHMKIARKRWEICKPLVEARMWAIEPLTTTIMQLAVCWQLSFKMVVYALPLLCFVSTECDPFKVVTPFLPWRIKGIVTIVQMLALTAELTASGALARRCDHEGLVGTLATADQVTMCEGLLRLVMKQGGDSNTGGWHVLKQAKAMLEDIEKLPGRETETAMLRVWEKDPEDPEASAFFHDQVIKPITTLASLAPEILEDKLGSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0C8</accession>
    <name>G0S0C8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CTHT_0009560</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent RNA helicase involved spliceosome assembly and in nuclear splicing. Catalyzes an ATP-dependent conformational change of U2 snRNP. Bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691480.1">
        <property type="nucleotide sequence ID" value="XM_006691417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0C8"/>
    <dbReference type="STRING" id="759272.G0S0C8"/>
    <dbReference type="GeneID" id="18254994"/>
    <dbReference type="KEGG" id="cthr:CTHT_0009560"/>
    <dbReference type="eggNOG" id="KOG0334">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_0_3_1"/>
    <dbReference type="OMA" id="QLPMKKW"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17953">
        <property type="entry name" value="DEADc_DDX46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22474">
        <property type="entry name" value="KH-I_PRP5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056149">
        <property type="entry name" value="PRP5/DDX46/KHDC4_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23469">
        <property type="entry name" value="KH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="577"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="608"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="797"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="996"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="577"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="21"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="121"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="191"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGS23289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1198" mass="132735" checksum="375A5C93950BA955" modified="2011-10-19" version="1">MARPRDSRSPSPAGSNAARRRKDDERRDRDRDRDRDRDRDRDRDRDRDRDRDRDRDGRRRSRSPDRWHRDRDRDRDYGRDPRDRDSYRWRDRSLDRRDDDYYRSSRRDGGINRERHRSRDRARSPDRRGRDYRGRRDDSRDRRGRRDDSVDSASRRGDDARPRSSKDTVTAKDEARVASPSPSPGVGPKLTCSQDSQPAKSTPTQALSEAEKKAERLRKLQAMKEKHALKEAKEADVTSGSTRQLLAEMDQKVGTATSATASAASPSSAPSNVSTPFAGKFDPKAIAKNARATRAQSPAKLGDVPLGVPGAKSAATISETGVKEAGGALPANRAISAFGFAKANDAQKSSSKRKLDMDDEEVIKRKLVKLPDFALENADNTPYADGDADEDGEQDLELLMARNNEEDMAEAHRILQERRDERIAQESMAMDIDTEPVNGKAKDEPTAMDVEEEELDPLDAFMANLEQTNTAEDRMVKRSQAQAEKKAFEPEAYFSDDDYGYEAENADPSAILAMAAKKKKKDIPTIDYSKIELNPVRKNFWVEPQELAQMTEEEVAELRMELDGIKVSGKNVPKPVQKWSQCGLTRPILDTIEKLGFEKPTPIQMQALPVIMSGRDVIGVAKTGSGKTMAFVLPMLRHIKDQDPVSGDDGPIGLILTPTRELCTQIYTDLLPFTKVLKLRAVAAYGGNAIKDQIAELKRGAEIIVATPGRMIDLLAANSGRVTNLKRATYIVLDEADRMFDMGFEPQVMKIFANVRPDRQTILFSATMPRIIDALTKKVLRNPVEITVGGRSVVAPEITQIVEVIEENKKFVRLLELLGELYANDDDVRALIFVERQEKADDLLRELLRRGYGCMSIHGGKDQEDRNSTISDFKKGVCPILIATSVAARGLDVKQLKLVVNYDAPNHLEDYVHRAGRTGRAGNTGTAVTFITEEQENCASCIAKALEQSGQPVPERVDAMRKSWREKVKAGKVKEASGFGGKGLERLDKDREAARLRERKSHKADGEDDDFGDDKPEDAVKDRATAAIEAAASAIVARDAPRADIKGDIKTPIVTGKGGALDKAASAISEINARLARAGQLRAGQPIDNKGPDAGAFHATLEINDFPQKARWAVTNRTNVAKILEATGTSITTKGTYYPPGKEPAPGGEPKLYILIEGETEIVVSKALAELTRLLREATLAAAEIESRAPVSGRYTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0F2</accession>
    <name>G0S0F2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione-specific gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0009810</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.3.2.7" evidence="1"/>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691504.1">
        <property type="nucleotide sequence ID" value="XM_006691441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0F2"/>
    <dbReference type="STRING" id="759272.G0S0F2"/>
    <dbReference type="GeneID" id="18255019"/>
    <dbReference type="KEGG" id="cthr:CTHT_0009810"/>
    <dbReference type="eggNOG" id="KOG3182">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070703_0_0_1"/>
    <dbReference type="OMA" id="DHREKDG"/>
    <dbReference type="OrthoDB" id="1933483at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061928">
        <property type="term" value="F:glutathione specific gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.10:FF:000021">
        <property type="entry name" value="Gamma-glutamylcyclotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006840">
        <property type="entry name" value="ChaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192">
        <property type="entry name" value="CATION TRANSPORT PROTEIN CHAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192:SF2">
        <property type="entry name" value="GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04752">
        <property type="entry name" value="ChaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="229"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS23313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="255" mass="29314" checksum="8147F52145B8CE9D" modified="2011-10-19" version="1">MSVDNNLADQGSEFWIFGYGSLIWKPPPHFDRRIPGWVTGYVRRFWQASQDHRGTPEAPGRVVTLIERSYWESLTDHHDKPPDKVWGVAYRIIPERVAEVKEYLDIREINGYTIHYTPFYPAPDVDSAQLPNGSREPFKTLVYIGTPDNDQFVGPQDPQGLAEHIYRSEGPSGLNRDYLWGLERALNELSPESGDDHVTDLANRVRAIAEKEGKAAEVLAGLEKVLEKERRHHEQPHLFRKVTSVDEEEETEKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0F8</accession>
    <name>G0S0F8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0009870</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691510.1">
        <property type="nucleotide sequence ID" value="XM_006691447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0F8"/>
    <dbReference type="STRING" id="759272.G0S0F8"/>
    <dbReference type="GeneID" id="18255025"/>
    <dbReference type="KEGG" id="cthr:CTHT_0009870"/>
    <dbReference type="eggNOG" id="KOG0270">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023867_0_1_1"/>
    <dbReference type="OMA" id="CFVPRGV"/>
    <dbReference type="OrthoDB" id="270624at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000457">
        <property type="entry name" value="rRNA processing protein Pwp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001345">
        <property type="entry name" value="WD40 repeat-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044285">
        <property type="entry name" value="PWP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="279"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="415"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="46"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="515"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="529"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS23319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="566" mass="62334" checksum="159DFF491011170C" modified="2011-10-19" version="1">MSMITTTAWVPRGFAAPFPTKSKFDEAEFQRIANLAKLKLEGAKEDLEEAEAAEAAEGDRMEDDAEESAKENGAGAGVDGGAGSKKKKEKKTKTAEEIAIDEELKEYDFEHYDDSDEDGEGQPLAMFGNIKSLAYYESNDDDPYITLKDDPEMEEEREDLQILATDNLLLAAKVEDELAHLEVYVYEDEADNMYVHHDIMLPAIPLCLEWLDIPVNKEGVDKNGVGNFVAIGTMDPDIEIWDLDTIDCMYPNAILGAGGDVEAEGKKKKKKKKSKKANDEYHVDAVLSLAANRKHRNLLASASADKTIKLWDLHTTKCAKSYTYHTDKVCSIAWHQVESTVLLSGSYDRTAAVADMRAPGEQPLRVGVESDVETVRWDPHDPNFFYVSTERGIIHHFDARTIGRDPAASKTVWKLQAHDESVSCFDLNPIIPGFMATGSTDRTVKIWNITPDNGPSLVVSRDFGVGKVFSTTFAPDKEVAFRLAVAGSKGVVTIWDTSTNAGVRKAFAHRQADLPSVEGKEEDRLVGLAEDEDEEESSDEGEDGVEGSDSSEDEEGARSGDAMDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0G9</accession>
    <name>G0S0G9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL2m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0009980</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691521.1">
        <property type="nucleotide sequence ID" value="XM_006691458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0G9"/>
    <dbReference type="STRING" id="759272.G0S0G9"/>
    <dbReference type="GeneID" id="18255036"/>
    <dbReference type="KEGG" id="cthr:CTHT_0009980"/>
    <dbReference type="eggNOG" id="KOG0438">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036235_3_0_1"/>
    <dbReference type="OMA" id="TAQRGNC"/>
    <dbReference type="OrthoDB" id="268576at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000034">
        <property type="entry name" value="50S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000128">
        <property type="entry name" value="50S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L2"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005880">
        <property type="entry name" value="Ribosomal_uL2_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_uL2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01171">
        <property type="entry name" value="rplB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 11" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="10">
        <location>
            <begin position="110"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="9">
        <location>
            <begin position="213"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="34"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="324"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS23330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="387" mass="42605" checksum="4EA760135A4F34E4" modified="2011-10-19" version="1">MLQQRFRPLVGGTVSLVSMYQSALRLSVASKRFSSTETQTTANNDAGSSSSSSDTFTTPPSNDFDPVKMRTYKPRTPGLRHLRRPINDHLWKGRPFLPLTFPKKGLGKGGRNNTGRITVRHRGGGAKRRIRIVDFYRWEPGPHIVDRIEYDPGRSAHIALITNQATGKKSYIVAAEGMRAGDVVQSYRSGIPKELIESMGGVVDYSILAAKTCWRGNCLPLHMIPVGTVVYNVGSRPDGPAVFCRAAGTYATIISKEEETREDGTKVMTGKHVIVRLQSGEVRKVSKDACATIGVASNIMHQYRQLGKAGRSRLLNIRPTVRGVAMNANDHPHGGGRGKSKGNRHPCSPWGQPAKGGFKTRKKSNINKWVVQPRIRNMGKRRNKTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0J5</accession>
    <name>G0S0J5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cation efflux protein transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0010240</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988037">
        <property type="protein sequence ID" value="EGS23356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691547.1">
        <property type="nucleotide sequence ID" value="XM_006691484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0J5"/>
    <dbReference type="STRING" id="759272.G0S0J5"/>
    <dbReference type="GeneID" id="18255062"/>
    <dbReference type="KEGG" id="cthr:CTHT_0010240"/>
    <dbReference type="eggNOG" id="KOG1485">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013430_10_1_1"/>
    <dbReference type="OMA" id="KKPIREY"/>
    <dbReference type="OrthoDB" id="78296at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1350:FF:000004">
        <property type="entry name" value="Cation diffusion facilitator 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000005">
        <property type="entry name" value="Putative Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF4">
        <property type="entry name" value="CDF DIVALENT METAL CATION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="8">
        <location>
            <begin position="232"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS23356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="515" mass="58078" checksum="557FCD19511C6DD8" modified="2011-10-19" version="1">MSSPTTPRSSVPKGAFLLLQDEPPLAPKGHGALAQLIRHRGREEEEAAAEGIEDETQRRDERRLSAILNSDNMRSMRLIGNTNLRYRWEQYWKTQEELAAMPKHIRKYHERVNYLVQQYLYIDRLLDSSLPHDLLNEYNNMPPSAFRGVEIPATIAETSHTAPVQPARKVNRTPRGIYRPTETTPLFSMPYDDDGEVVTDLNLEHGRQKPEIPWLEDELVDSDAPIVTLAIYVNFAANTILLAGKIAVIISVPSVSVLASLVDALLDFLSTVIVWLTTWLIRRRDQYLYPAGRRRLEPLGVLVFSVIMITSFVQVAIEAIGKLASPKHEIIELGIPAIAIMLSTIFIKGLCWLWCRLVNNSSVQALAADALTDVIFNAGSIAFPIVGWLAEIWWLDPLGGLLLSLIVIFNWSQTSWEHIRHLSGLSATADQRNILLYLTMRFAKTIKQIQGLQAYHAGDKLIVEVDIVLDASTPLRDSHDLSESLQYVLESVPIVDRAFVHVDYATYNLPTHMEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0Q3</accession>
    <name>G0S0Q3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0010840</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691605.1">
        <property type="nucleotide sequence ID" value="XM_006691542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0Q3"/>
    <dbReference type="GeneID" id="18255122"/>
    <dbReference type="KEGG" id="cthr:CTHT_0010840"/>
    <dbReference type="eggNOG" id="ENOG502T5YR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_340649_0_0_1"/>
    <dbReference type="OrthoDB" id="424753at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="609"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="656"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="407"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="622"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="715"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="833" mass="90604" checksum="965277FFE9B57D2F" modified="2011-10-19" version="1">MPRPTASDPDAPPKLLLTGAINPFALAEALLHRKLDWSAPATRHRILPALLQTDYDELFDMRFRSVLYAGVRINNFGGVERVPEEEVRIFCEGDGEEEEEEGRDDLSGARKLGDLKRMIGLGGEEIEELGVKRAVVSNGNLHVTLVLSGEVAGWAGRRMSCEEMTAEIRELATPYRRNSLYRQPSGEKEEELWTPPGGRWMDVSAWNHRDVTMFTNPVQGAAPNSWFVAALMSVDWAEPGKIERCVPKGEACQYMYPEDFNDDNTEGLGALETESVVGENYGDYNDTNNPWPEEKPACTLATTFYSQGGDNDAPTAKITVDCVLPTNSTTSLLVYCRPSSLNYAYPPTLTSGDWRGELWPALYEKAFAVWLSTGKKTVPSESSCMINSSPALSATTPDSNFDPPDGTTSPTSSSPATSETAESNTAASLLPDLVLTCQGDPVKALAQLTSRPPMYFHTSCRTATDLLALVRLHSSNLRVTTPMVAWTRPTSDDGAFCRGATLVGNMAYSVLGWATRGSAATVGDEETGTGLSRSASVRSMSGMREGELGRSVSTRSRNGTAGSELECSVSVRSMRGVVRSELGRTRSVRNKIATAGSELCRSSSVRNRASAMNRVSDSTLTRSVSVRNRSSSVSSPPIGLARSDSIQSHIGALAQEHQLTRHRAASVSSEADDLPLTRPRSKSMGSMTSEMVRRPSLRSRTNPLSNDPDVIPENSPGQKSRPSTPTRNQSLSIGNPVAEQPAKPVQKQFIVLRHPWGVTPPLEDPYAKRWPTSPFDGDEVDGAKKDQEECPYGVIVDVDEDFWPPVATLDETSVFAVEISVFKEYFAGLGLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0T4</accession>
    <name>G0S0T4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0011160</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691636.1">
        <property type="nucleotide sequence ID" value="XM_006691573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S0T4"/>
    <dbReference type="STRING" id="759272.G0S0T4"/>
    <dbReference type="GeneID" id="18255154"/>
    <dbReference type="KEGG" id="cthr:CTHT_0011160"/>
    <dbReference type="eggNOG" id="ENOG502SATC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042176_0_1_1"/>
    <dbReference type="OMA" id="RENEHMA"/>
    <dbReference type="OrthoDB" id="5946236at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053269">
        <property type="entry name" value="Asp-Met_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37018">
        <property type="entry name" value="CULTURE SPECIFIC PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00130)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37018:SF1">
        <property type="entry name" value="CULTURE SPECIFIC PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00130)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="590" mass="65125" checksum="CBC674FFA8C769EB" modified="2011-10-19" version="1">MSRIPDSDIVDPSEPLRLPTITLDTTISDLYRLANPSSPDRRIAWLACGTSSGVNLTPSVPRNVKYSYQDQAFISAPWKDLLSPSAAFQRTLAKKHLTLVAQRDAFIAGKALMVQFHIGRDEEEKKWDVLEAERTLSVLNETQRPEMVFCTGPGDLPEKVKEKGIEQVEYKIVFDDLERAIPRSHSLETHWMLNSKAALARSGLPTPKAEVIEPEPGWPGVEPGDCCAVCGEIAEQTNLPFIPPGCSGPRGEWLAQQTERIIAAVRAREVPFVFKTQQCWGGAGTWLVPDEEAKRRLLGDLEDTPGLNEGDGLLRKLLSLQTRENEHMAPGAILLMEMITAPKADYGLTFVVTETGEAVFLAAAEQMIARSTPGNSPSSTESSTPSLSASLSDDGNSSSSSSTSNESNTLSHGTNTTKTSTTSGVSWVGSTIHYTRQSILQERFMPLMSRIARWIHNASNCTYTGPVGADVLELDPDDDPQGRTCVIVDLNVRTCGSMCLPLLRTHFVRRGMNCAAGFSMRVCGLRRVDFFRRWRTMLEEGRMIILSWFEERLEEGEMESLVDVVIGAEDEEGLREVMRMVRGGTEEVAF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2017-09-27" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G0S0Y3</accession>
    <accession>A0A068EX63</accession>
    <accession>A0A068F1B9</accession>
    <name>PAN3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PAN2-PAN3 deadenylation complex subunit PAN3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">PAB1P-dependent poly(A)-specific ribonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Poly(A)-nuclease deadenylation complex subunit 3</fullName>
            <shortName evidence="1">PAN deadenylation complex subunit 3</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">PAN3</name>
        <name type="ORF">CTHT_0011660</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="EMBO J." volume="33" first="1514" last="1526">
            <title>Structural basis for Pan3 binding to Pan2 and its function in mRNA recruitment and deadenylation.</title>
            <authorList>
                <person name="Wolf J."/>
                <person name="Valkov E."/>
                <person name="Allen M.D."/>
                <person name="Meineke B."/>
                <person name="Gordiyenko Y."/>
                <person name="McLaughlin S.H."/>
                <person name="Olsen T.M."/>
                <person name="Robinson C.V."/>
                <person name="Bycroft M."/>
                <person name="Stewart M."/>
                <person name="Passmore L.A."/>
            </authorList>
            <dbReference type="PubMed" id="24872509"/>
            <dbReference type="DOI" id="10.15252/EMBJ.201488373"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)</scope>
        <scope>X-RAY CRYSTALLOGRAPHY (2.42 ANGSTROMS) OF 293-640 IN COMPLEX WITH ATP</scope>
        <scope>FUNCTION</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="journal article" date="2014" name="Nat. Struct. Mol. Biol." volume="21" first="599" last="608">
            <title>An asymmetric PAN3 dimer recruits a single PAN2 exonuclease to mediate mRNA deadenylation and decay.</title>
            <authorList>
                <person name="Jonas S."/>
                <person name="Christie M."/>
                <person name="Peter D."/>
                <person name="Bhandari D."/>
                <person name="Loh B."/>
                <person name="Huntzinger E."/>
                <person name="Weichenrieder O."/>
                <person name="Izaurralde E."/>
            </authorList>
            <dbReference type="PubMed" id="24880343"/>
            <dbReference type="DOI" id="10.1038/NSMB.2837"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.89 ANGSTROMS) OF 522-629</scope>
    </reference>
    <comment type="function">
        <text evidence="1 3">Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 3">Homodimer. Forms a heterotrimer with a catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein PAB1 (via PABC domain), conferring substrate specificity of the enzyme complex.</text>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-9836608">
            <id>G0S0Y3</id>
        </interactant>
        <interactant intactId="EBI-9836534">
            <id>G0SAK8</id>
            <label>PAN2</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>9</experiments>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>G0S0Y3-1</id>
            <name>1</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>G0S0Y3-2</id>
            <name>2</name>
            <sequence type="described" ref="VSP_059086"/>
        </isoform>
    </comment>
    <comment type="domain">
        <text evidence="1">The N-terminal zinc finger binds to poly(A) RNA.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. PAN3 family.</text>
    </comment>
    <comment type="sequence caution" evidence="5">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EGS22693" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="KJ657770">
        <property type="protein sequence ID" value="AID55017.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KJ657771">
        <property type="protein sequence ID" value="AID55018.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22693.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691685.1">
        <property type="nucleotide sequence ID" value="XM_006691622.1"/>
    </dbReference>
    <dbReference type="PDB" id="4CYI">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.42 A"/>
        <property type="chains" value="A/B/C/D/E/F/G/H=205-640"/>
    </dbReference>
    <dbReference type="PDB" id="4CYJ">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.59 A"/>
        <property type="chains" value="A/B/C/D=205-640"/>
    </dbReference>
    <dbReference type="PDB" id="4D0K">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.89 A"/>
        <property type="chains" value="B/C=522-629"/>
    </dbReference>
    <dbReference type="PDBsum" id="4CYI"/>
    <dbReference type="PDBsum" id="4CYJ"/>
    <dbReference type="PDBsum" id="4D0K"/>
    <dbReference type="AlphaFoldDB" id="G0S0Y3"/>
    <dbReference type="SMR" id="G0S0Y3"/>
    <dbReference type="DIP" id="DIP-61542N"/>
    <dbReference type="IntAct" id="G0S0Y3">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="MINT" id="G0S0Y3"/>
    <dbReference type="STRING" id="759272.G0S0Y3"/>
    <dbReference type="GeneID" id="18255204"/>
    <dbReference type="KEGG" id="cthr:CTHT_0011660"/>
    <dbReference type="eggNOG" id="KOG3741">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016423_1_0_1"/>
    <dbReference type="OrthoDB" id="204958at2759"/>
    <dbReference type="EvolutionaryTrace" id="G0S0Y3"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03181">
        <property type="entry name" value="PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030844">
        <property type="entry name" value="PAN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041332">
        <property type="entry name" value="Pan3_CK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272">
        <property type="entry name" value="DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272:SF11">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18101">
        <property type="entry name" value="Pan3_CK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25586">
        <property type="entry name" value="zf-CCCH_PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0025">Alternative splicing</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000441675" description="PAN2-PAN3 deadenylation complex subunit PAN3">
        <location>
            <begin position="1"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pseudokinase domain" evidence="1 6">
        <location>
            <begin position="237"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Knob domain" evidence="1 6">
        <location>
            <begin position="538"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1 6">
        <location>
            <begin position="499"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 3">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <feature type="binding site" evidence="1 3">
        <location>
            <begin position="338"/>
            <end position="345"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 3">
        <location>
            <begin position="397"/>
            <end position="398"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="splice variant" id="VSP_059086" description="In isoform 2." evidence="4">
        <original>MAPLDLTRGQTDACSTENKDILCRNVLIYGHCRYEDQGCTYNHDQNKNSSQPEAPSKKMFNVDSPSFTPSGQSTVLPKKTTLSSQAASAAPFTPRGGGT</original>
        <variation>MTKTRTPPNQKP</variation>
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="helix" evidence="13">
        <location>
            <begin position="209"/>
            <end position="213"/>
        </location>
    </feature>
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        </location>
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        <location>
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    <feature type="strand" evidence="12">
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        <location>
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        <location>
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        <location>
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        <location>
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        <location>
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        <location>
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        <location>
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        <location>
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        </location>
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        <location>
            <begin position="613"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="24872509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="24872509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <evidence type="ECO:0000305" key="6">
        <source>
            <dbReference type="PubMed" id="24872509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS22693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="9">
        <source>
            <dbReference type="PDB" id="4CYI"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="10">
        <source>
            <dbReference type="PDB" id="4CYJ"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="11">
        <source>
            <dbReference type="PDB" id="4D0K"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="4CYI"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="4CYJ"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="4D0K"/>
        </source>
    </evidence>
    <sequence length="640" mass="71813" checksum="ABE58EFE0C199D61" modified="2017-09-27" version="2">MAPLDLTRGQTDACSTENKDILCRNVLIYGHCRYEDQGCTYNHDQNKNSSQPEAPSKKMFNVDSPSFTPSGQSTVLPKKTTLSSQAASAAPFTPRGGGTPTLQTTAESTMFNPAAIREFTPQNYDLGNNNANGISQENGLYPDPFTMSTMGTALPTAGQYNLPLYGDHSGLAAPGAPFYPPHAAYPTGPIQPPHYHLYQPFGPYRQELQPWQRATYDFFMPQNLREDLQKKQFATLQVIPNSGLPQLEHWHSLVPLDTSNRKNTSCFGYPSWVYKAQNSRNGRHYALRRLEGYRLTNEKAILNVMKDWKKIKNASIVTIHEVFTTREFGDSSLIFAYDFHPLSKTLQEHHFQPIHGNRYRPPPAVPENTIWGYICQIANALKTIHSNRLAARCLEPSKIILTDINRIRLSACAILDVVQFGMNSRSVVELQQEDFVKFGKLILSLATGTLPAHLNNIPAALETLGNKYSANLKSAVNWLLDTSSGETKTIEHFMTGIASQMTTFFDLALQDNDEKLFHLAREVENGRIARSLMKLLTILERGDYDGVPSWSETGDRYQLKLFRDYVFHRVDADGKPNLSIGHMLTCMSKLEAGVDENILLTSRDNETVFVLSYRELRQMYDRAFNELVKASKTGAPGANT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0S112</accession>
    <name>G0S112_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Urea transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0011960</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006691651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S112"/>
    <dbReference type="STRING" id="759272.G0S112"/>
    <dbReference type="GeneID" id="18255234"/>
    <dbReference type="KEGG" id="cthr:CTHT_0011960"/>
    <dbReference type="eggNOG" id="ENOG502QU2F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023225_0_0_1"/>
    <dbReference type="OMA" id="WWTAFEV"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050277">
        <property type="entry name" value="Sodium:Solute_Symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48086:SF10">
        <property type="entry name" value="AGR155CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48086">
        <property type="entry name" value="SODIUM/PROLINE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
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        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS22722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="557" mass="60127" checksum="1740C68B4449FF45" modified="2011-10-19" version="1">MGQPSFPASNALIYSTYGAFLIVGTGVAWRFRNQSKGEFLAGNRTQTALPLALNFIASGSYPDLIDTPPLRFPCLLRDLAFCFLQWQRQTLGSGILFAYPQLGTLAGVQGVVVYALASGLPLLAFATLGPIIRRKCPQGFVLTEWTRQRYGTITALYLSFMTLVTLFLYMVSELSAIGQVVNLLTGLDGLPVLIVECLVTTIYTSLGGFKISFFTDNIQGAMVLGLIIIATITIGVETKIDTGLIESSGLTKGNLLGWQLLYILPVAILTNDFFLSQFWLRTFASKTDRDLWLGISAAVVAIIIIVTLVGSTGLIAAWSGVWPGPPDNPVDGSVAFFALLQQLPSWVVGIVLVMSVTLSTAAFDSFQSAMVTSASTDLFRNKLSIWWIRAGVVLTMIPVVVIAIRAPSILQIYLISDLVSAATIPVLILGLSDACYWWRGFEVVVGGLGGLFTVFLFGTVYYGDVKSGAELMLLQQGLFTGDWGCFGAFVAAPIGGLLWGFGALALRLGIQYTRAKLQGKRFDSLDRPVSLDEEGHGWETESSSDNPGIAETTGKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0S139</accession>
    <name>G0S139_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA(Phe) 7-[(3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4)]-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.282</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0012240</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36635"/>
            <dbReference type="Rhea" id="RHEA-COMP:10378"/>
            <dbReference type="Rhea" id="RHEA-COMP:10379"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73543"/>
            <dbReference type="ChEBI" id="CHEBI:73550"/>
            <dbReference type="EC" id="2.1.1.282"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TYW3 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.282" evidence="2"/>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691741.1">
        <property type="nucleotide sequence ID" value="XM_006691678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S139"/>
    <dbReference type="STRING" id="759272.G0S139"/>
    <dbReference type="GeneID" id="18255262"/>
    <dbReference type="KEGG" id="cthr:CTHT_0012240"/>
    <dbReference type="eggNOG" id="KOG1228">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047426_0_1_1"/>
    <dbReference type="OMA" id="TWLYVSH"/>
    <dbReference type="OrthoDB" id="263283at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1960.10">
        <property type="entry name" value="tRNA wybutosine-synthesizing-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003827">
        <property type="entry name" value="tRNA_yW-synthesising"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036602">
        <property type="entry name" value="tRNA_yW-synthesising-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48418">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48418:SF1">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02676">
        <property type="entry name" value="TYW3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111278">
        <property type="entry name" value="SSo0622-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA wybutosine-synthesizing protein" evidence="9">
        <location>
            <begin position="14"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS22749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="292" mass="31488" checksum="F66A224120213E7A" modified="2011-10-19" version="1">MKNLPTPGKVFISKKQKILSQLSLPDEQYTDASPKGSVDEGIRYLIDQINMQAGLVTTSSCAGRVSVYLEGPKFGQGASSSDGEETAGNGDVAVEAGRENAVASSVGGKGGGEWLFVSHDPVKNDAGESGYERLFGFGTVPAREQFVQDVFAPSTRLIHFKFEPMILHILTASLEHAQLVIQAGMEAGFRESGAVSLLKKSGDDDANPMVAIRSMGLSFDSLIGAENDGIRRLIVSSEYLKMLVRIANERFVENQKRIARFSAALESAFAPPKAKANWESAQARREQGVNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G0S174</accession>
    <name>G0S174_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 1A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 4C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0012590</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the eIF-1A family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691776.1">
        <property type="nucleotide sequence ID" value="XM_006691713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S174"/>
    <dbReference type="STRING" id="759272.G0S174"/>
    <dbReference type="GeneID" id="18255297"/>
    <dbReference type="KEGG" id="cthr:CTHT_0012590"/>
    <dbReference type="eggNOG" id="KOG3403">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109098_0_0_1"/>
    <dbReference type="OMA" id="KMEDQEY"/>
    <dbReference type="OrthoDB" id="274995at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000071">
        <property type="entry name" value="Eukaryotic translation initiation factor 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00216">
        <property type="entry name" value="aIF_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00523">
        <property type="entry name" value="eIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="EIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="10">
        <location>
            <begin position="22"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="118"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS22784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="159" mass="17956" checksum="CEFC72A7F232492D" modified="2011-10-19" version="1">MPKNKGKGGKNRRRGKNENDNEKRELIFKEEGQEYAQVIKMLGNGRLEAYCFDGVKRLGLIRGKLRKKVWINNGDIILISLREYQDEKGDVILKYTADEARTLKAYGELPDTAKINETDTFGGADDGDCGFEFDEDRDSESDDGGAADDKKKEIDIDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1F1</accession>
    <name>G0S1F1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0013370</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691853.1">
        <property type="nucleotide sequence ID" value="XM_006691790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1F1"/>
    <dbReference type="STRING" id="759272.G0S1F1"/>
    <dbReference type="GeneID" id="18255375"/>
    <dbReference type="KEGG" id="cthr:CTHT_0013370"/>
    <dbReference type="eggNOG" id="KOG1844">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020879_0_0_1"/>
    <dbReference type="OMA" id="RPRYMNP"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061188">
        <property type="term" value="P:negative regulation of rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061186">
        <property type="term" value="P:negative regulation of silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053051">
        <property type="entry name" value="HDAC_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47793">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT CTI6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47793:SF1">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT CTI6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20826">
        <property type="entry name" value="PHD_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="107"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="206"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="274"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="540"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="213"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="274"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="341"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="387"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="424"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="448"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="476"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS22861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="600" mass="65136" checksum="2561CF0E4DE827D7" modified="2011-10-19" version="1">MAGSDPRRSSRARSNNQSHNSSSASSVSGRPERSTRNSFNKGVSPQKSASTGSLSEPPEDSITAEDPFGTRRRTRGQAEDREKASSKHDTKDTAHDDEVQEEDEAVRCVCGNEEYQGPPPPEDEAKHGSKHDPDSFFSADVTDDTAGLFVQCDICKVWQHGGCVGIMTEESSPDEYFCEQCRQDLHRLWTASNGNVYSHYLPLRKHARTSSRAARESARSPTKETQTRNNSNNNSNGGRASSQSQTSKRRSTLNSREAGYDEAEALRRAIEASKEEAEQANRRPKRGRSDSQEKPDNKRQRTDSRSVSPPPDTKAEESDDGGAITRNGKSKSRGGAAARNQRNEKPSEKEEKERQAEANNIKNNKKNNKSDRRRAEDSDPSEEMPLAASRATTAKTASQTSNTSNPANTNSIATEPTQPQEASEPPPTSQPTPDSPPAVSVPASKSDSKKKSHKKKGRNQYTRDRDDESPGGSQSREAKDEAGSTGGGKHEGSAGSTGGGKGSKHKGGMSSKITMNDMRRRVGALLDFISRTQLELAGEGGPMTGIVSHAPNGGSAAGGGGDKEGEEGERQERDFKELGCLEMMDSLTRRLVKWQQQYAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2023-02-22" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>G0S1M1</accession>
    <name>G0S1M1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0014090</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988039">
        <property type="protein sequence ID" value="EGS22931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006691923.1">
        <property type="nucleotide sequence ID" value="XM_006691860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S1M1"/>
    <dbReference type="GeneID" id="18255447"/>
    <dbReference type="KEGG" id="cthr:CTHT_0014090"/>
    <dbReference type="HOGENOM" id="CLU_2061229_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="119" mass="13161" checksum="19EA2F580479126D" modified="2011-10-19" version="1">MPLQRRHGQPDRSTGCQEGRAWQRAASMSRRRDETTLAVPVKLGSGVILTSHPAVLTRPGPSLALCWMRASESWEQSGHDFSAGARGLFWVLLGTEQRLRVNNRAPSAPSWLGAQTDQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2N5</accession>
    <name>G0S2N5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1748-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0017870</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692287.1">
        <property type="nucleotide sequence ID" value="XM_006692224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2N5"/>
    <dbReference type="GeneID" id="18255825"/>
    <dbReference type="KEGG" id="cthr:CTHT_0017870"/>
    <dbReference type="eggNOG" id="ENOG502S6Z8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151392_1_0_1"/>
    <dbReference type="OMA" id="NKEVGKW"/>
    <dbReference type="OrthoDB" id="16824at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013726">
        <property type="entry name" value="Mitofissin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075:SF1">
        <property type="entry name" value="DUF1748-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08520">
        <property type="entry name" value="Mitofissin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS22268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="86" mass="9786" checksum="0B83DCCF9D7209FA" modified="2011-10-19" version="1">MLLDLLTFGLWSKLGRLTHYAFDAVLLSAFLAGMKRSTGLTFKTERLAGENKDLEKWVNKYLSVGEWVMDQSVALAGSSGWFERRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G0S2Q8</accession>
    <name>G0S2Q8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0018120</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692310.1">
        <property type="nucleotide sequence ID" value="XM_006692247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S2Q8"/>
    <dbReference type="STRING" id="759272.G0S2Q8"/>
    <dbReference type="GeneID" id="18255850"/>
    <dbReference type="KEGG" id="cthr:CTHT_0018120"/>
    <dbReference type="HOGENOM" id="CLU_399005_0_0_1"/>
    <dbReference type="OrthoDB" id="4776573at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="690" mass="74633" checksum="353AE1B9817F0E3C" modified="2011-10-19" version="1">MKRRLSKRICSGENQRTPINSSSPAAAAASSSPASGSASKSVGSKESSASPSTDRVANKLRKGPPGYRSSSVTSPLAAKVPEDACPLTELTGSTIQETLQPKKTSTSSDVKAVQPVQIQLRADEQPVWDRAVEMTWAKPARKDKKADQEEEGVFLKIWKLLMEEYPSIDKTGEDEYFSDSDEISTDSSATPTLTPDKTTPTIKFVRHRSYSDLPPTVRLQLLRCLLAAHDLTTNKAIPLADKFTTSELTRYHGLNQFTALSTLLSPITRYLLINRSFRADVLATVFLTYRFHILVSALTPRMIFSRTPEGQFLARYGRLFANVVVEVDMTKLTGSKDPDAVGLVASVGVGKVKGVLDGLIVKSQVAKRPKGLPLRDFRVLVRRYFGERPQNTPAKFYASSEEVEKVLAPLKSLFPFVEKITISGGVDVTQAMEMIKSVCGAEASLSDGWFERRLPAKEWGAIQGEAAVVDFGTPADGNEMEGLWVVRYTDLGMDSVRKVQEGEVVVGCPTPTATSTAAPDNVKQAGQRVIVLDTNKLSRLPVGKTRAATAAKAEAQSQCQTQAPSQSSSGLSRTVSVSFRRALSAMGRDNLDTPFVQLPSKSLAAEKAVENKLPQPQAQCMPVAPEKEKGQEDKAGVVAVGMAGGEGKKELTGTGVFEEDWKGVKKGDTLRGGRRVLKKLGGALRSLGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0S393</accession>
    <name>G0S393_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase S8/S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0020170</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692495.1">
        <property type="nucleotide sequence ID" value="XM_006692432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S393"/>
    <dbReference type="STRING" id="759272.G0S393"/>
    <dbReference type="GeneID" id="18256055"/>
    <dbReference type="KEGG" id="cthr:CTHT_0020170"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011779_0_0_1"/>
    <dbReference type="OMA" id="SHARHNT"/>
    <dbReference type="OrthoDB" id="3866712at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04843">
        <property type="entry name" value="Peptidases_S8_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034073">
        <property type="entry name" value="Subtilisin_DY-like_dom"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003408789" description="Peptidase S8/S53 domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="699"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="777"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="838"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="838"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="908"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="925"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS22476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1009" mass="104062" checksum="03E767FD1E510B32" modified="2011-10-19" version="1">MHYPLFRAALGLLFLWVILAQAQEQSFAIKLNNVAYVRQRSNSSFISSLIKRVGYNGQEPKSVAVKPLFRQDLLAKIDRQATNNQRHSLDRWYEVKIVPAPEPVVVLRRNDTLSEDPAQGDKIPAYVVKFMQDLIKLQEITNIHPLLDHDDPQVDTINPADDPRSGRQGYLDPAPGGIDARYAWRVPGGTGRGVTVVDLEQGFNLDHEDLPRNIDLIGGHIIASSRFHGTGVLGELFMVDNKIGGVGIVPNARGRVVSYGTASGGEDIPNAILEAVAVLHFGDILLLEVQTRDPVTGTRGWPVEIRDEIFEEIQYATSLGITVIEAAGNGGYDLDNYQNIEGDRIFFRQGGLRSGFRESGAVMVGAASSTVPHTRMWFSNHGSRVDVYAWGENVATAFANTTIGVNNLYTDTFNGTSSASGIIAGAAAAAQGMSVAHRNIRLSPQQMRTILQVNGTQSRNPGVDRIGVMPNLRSIADQIANPDGQFAVDVYFRDQVGDVGLVPTTGGVYRSPDIIVRQWPYVNPSTALGTGSGTEDNVALSHDVVSGREHSLYVRVQNRGTADTSQDTEVKLWWSRPTTLNTPNLWNFIGTALIRAPVRGSRQRFSVSDRLAWPANRLPPALPNQKDHYCFVAIADTPNQDPEPLLPQSFEQFDRFVKENNNVAWRNFNTFTLNTHGKLPAGSQAFIRVPRNFTSALGDGGRFGDLGKGNGGGSGGNGGNGGDGGDGGAGGNGGRGGNGGNGGDGGNGGSGGNGGNGGNGGHGGNGGNGGDGGAGGSGGNGGNGGSGGNGGDGGHGGNGGNGGNGGNGGNGGNGGVGGNGGSGGNGGNGGDGGSGGNGGNGGNGGNGGDGGSGGNGGNGGDGGDGGDGGDGGDGGDGGNGGDGGQGGDDWDDDDSCGGHGGRGEKGSKGGYGRGGRGGHGGKGCKCHDKRQTHNQGDEKVQVELKIDGDETLGVGVLPQGSITEVEIFIKVPDTAYTNGGEHEFAIAQAWKGSELGRVTWRFAAVDLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3D6</accession>
    <name>G0S3D6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0020630</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692538.1">
        <property type="nucleotide sequence ID" value="XM_006692475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3D6"/>
    <dbReference type="STRING" id="759272.G0S3D6"/>
    <dbReference type="GeneID" id="18256101"/>
    <dbReference type="KEGG" id="cthr:CTHT_0020630"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_302059_0_0_1"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="199"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="336"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS22519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="988" mass="110882" checksum="60E7E01A63673D36" modified="2011-10-19" version="1">MPSLLSLSNQVFEIVCHAIYPEDVCYDRVSLKSLAALARTNKRLSSIATMIFYARGVFSHLHLPLAWGAKFGLRETLNMALAVGADPNFLFYADVDYRLWVASLRSYESHRAFQRGDKDFWPPFDRNLLTRYRERFGKAANALHPDLVDLDIIAPTNEYKLYGAYQATTPDGGFVDEDDCRDEITLATEYEERDRSIPRTFTAAHLAAREAHNEIISILVDHGADLSIYTNGPCICHPPPFAGFWFLPSEGAMGVSSPHNWSPLHVALCSSHIETAKLLLSNGAAVVPSGILSSSPGQMRPDFGILFEAAARGHADVLQHIFDLHPNIDVNCVDQTGQTALFYAFLNRRWDSTIPLLLERGADINFAVGCDVGNQHIEATCLDIACRLGRFEDALRLLDLGAKITRMSVSHLGALLNAPPNFRVDPLQLCAIDFKEWQKPNCCRFLEEFVYFQDEDASHMVETCATRVNLIEDRTMEIQRQAQLQERFWPQLIERLIREGGLSADNILLWDPLGNSGHPTTLMLAVQSLNLPAVDALITHGKPKIGILQPHEGWSNRNALMAFVAKLPQRLVFQFGGRTHCWEDLGIVPCKDWNLPLLDDYPKRFIIVKKLVGLQVPVNHQDDDGNTVLHLLFESTAAGEKFMNPRSAELILRYLLDHGASASLLLRNKRGETAFECSIRNKCAYALDIIASKGLIRNLFDHFDIREVTCMFEVTATIPTLLDAPSNDKDEDDDTVVSSEEIVKITVDSLLMEFSLRVDSNNPLGNDGAELLFYAIGNDAPHSTIVHLLDMGAQAHRIAVPEPPRKNWSLHPLAPRTPFEKAIQANRCDVFESILLRQPLSDDGSSAGRPVQDLHLALDNFVEPCRLTPYNCVRASVEKRIQAEKYLRVHLAAGVSPASVDMNGHTALVRVLKRIDTDPELGLDVFHLLKPLCRGLDLKRKLPYLDYGLSVTEYLEKLISEDRYLEQLKEWLKIVTSKNGEKELQWVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3E8</accession>
    <name>G0S3E8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0020760</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692550.1">
        <property type="nucleotide sequence ID" value="XM_006692487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3E8"/>
    <dbReference type="GeneID" id="18256114"/>
    <dbReference type="KEGG" id="cthr:CTHT_0020760"/>
    <dbReference type="eggNOG" id="ENOG502R7SG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_3_0_1"/>
    <dbReference type="OMA" id="MLSIWIP"/>
    <dbReference type="OrthoDB" id="5417887at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF42">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="51"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS22531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="286" mass="32998" checksum="1A1348CD963C4FA2" modified="2011-10-19" version="1">MSSDNLNPTTILSSSITRRLVNTDNGDESIFSQTNVAVWVLMSASAMFLFMRLWCRHHFSKWWYDDGVLTITWMILLTAAALISAAISVGYHTDDAKRTFFLYQNISTSLTTIGTAWTKVAFALTLMRIMRNIYLRYVLYFVIVTVNLVLVLGMLSIWIPACTDPRKHLRPQHDLCFDHMNLMYLGGTTMVYGGLIDVLLALFPWFIIHRLLLETREKLGLSFAMSLGFISGMIVILRTFFQFKRIDNNYHYLAFLAIFNFLEPCVNIIAQTTPQLRVFCHRYKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3I1</accession>
    <name>G0S3I1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0021120</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988040">
        <property type="protein sequence ID" value="EGS22564.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006692520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3I1"/>
    <dbReference type="STRING" id="759272.G0S3I1"/>
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    <dbReference type="KEGG" id="cthr:CTHT_0021120"/>
    <dbReference type="eggNOG" id="ENOG502QQIE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012066_2_1_1"/>
    <dbReference type="OMA" id="MILTECE"/>
    <dbReference type="OrthoDB" id="415532at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025340">
        <property type="entry name" value="DUF4246"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049192">
        <property type="entry name" value="DUF4246_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049207">
        <property type="entry name" value="DUF4246_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119">
        <property type="entry name" value="IFI3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14033">
        <property type="entry name" value="DUF4246"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21666">
        <property type="entry name" value="DUF4246_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4246" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4246" evidence="2">
        <location>
            <begin position="64"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4246" evidence="2">
        <location>
            <begin position="146"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4246" evidence="2">
        <location>
            <begin position="360"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS22564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="475" mass="55205" checksum="0E1728611AA5B7D9" modified="2011-10-19" version="1">MMLMDALTDKPDWHNKVQDETVVDKWRQEALSQDEQELWTYIVPRKQASSNLNEAADIGCGGQCIQELKIKAEFFRQTGLIYTLNADANAVIKSDSLVGADLREQFQFAFEKLQAEQQADPLWHPDMCGRPMSKTWFIHLGTRLFMNGTVKFTSYINNLHPTKHVEIYRLIERLIDIAIPAWDQILTPLTPEGGRRCCITPRRIDLGPEVEDENGDQVEDLWEDLNLEIIAAYEAEHGEIKPWGSDNPEENLSRRDKEELQDKEARWARGIARIKWKKLREPKLPEPEEFRPPNFSAGSDLRKQYKNSGLQITVKMVSIELTPEISEFEEGGWHVAQLPKRTDVSRRVKVVSSPSLMLCHRRFIALWLVDPSQRIISTANLPPQRFDWWAEAQYNYEEKPLATNDRVLRSVFGSSYTRLPVEIKDMILTECEEMETLMTREEAEKHVEQLMDERTIFDADEVDPLGTWDYNFCEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3J6</accession>
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        <recommendedName>
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        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">CTHT_0021490</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692619.1">
        <property type="nucleotide sequence ID" value="XM_006692556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3J6"/>
    <dbReference type="GeneID" id="18256187"/>
    <dbReference type="KEGG" id="cthr:CTHT_0021490"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_1_2_1"/>
    <dbReference type="OMA" id="CLYLLYN"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF33">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="469"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS20323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="537" mass="59806" checksum="77D165FB301B8565" modified="2011-10-19" version="1">MADNEKTSISTSHQEEAGNVQEAHYDHRSHSDKEKNTAHGSSSDLSSTAEVESINVGQRGRRASVATTARSHRESFYSQRSVDPAEVQAAVPGHDLDVELAQGRHSPTELARIQSHASVRSRLSRILTNTSARQRERIPFAPLPLTNLDEGIVGWDSQSDPAMPLNFPARKKWTMVSLLAAITFLTPFASSILAPGITALQKEFNNYNSVVGTMTVSVYLLGYVVGPLFLAPLSPTIGPVIGSFVSQTIGWRWSFWIVFITSVVVVATHELNNTETNPRVLIKRKVERLKKELGRDDLRSCYEINAEEKTHLQTLLNGLIRPTKMLFYSPLVFFVSLYIAFTYGTLYLLFTTIPTVFMQSYGWSLGLTGLVYICLGLGNLVGWAVITARSDRSVVRRTKENGGVFEPEMRLPISIYFSVFLPMTFFWYGWSAHYKTHWIVPIIGLFPYSFGGIGIFMPLTTYLVDCYPMYAASAIAANTVIRSLAGMLLPLAGPKMYETLGLGWGNSLLGFICILMIPVPLLLHRYGKKLRMMGMQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3S0</accession>
    <name>G0S3S0_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0030410</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC45 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693492.1">
        <property type="nucleotide sequence ID" value="XM_006693429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3S0"/>
    <dbReference type="STRING" id="759272.G0S3S0"/>
    <dbReference type="GeneID" id="18257079"/>
    <dbReference type="KEGG" id="cthr:CTHT_0030410"/>
    <dbReference type="eggNOG" id="KOG2475">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005871_3_0_1"/>
    <dbReference type="OMA" id="EDCFMEA"/>
    <dbReference type="OrthoDB" id="10258882at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902977">
        <property type="term" value="P:mitotic DNA replication preinitiation complex assembly"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003874">
        <property type="entry name" value="CDC45"/>
    </dbReference>
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        <property type="entry name" value="CDC45-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507:SF0">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 45 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02724">
        <property type="entry name" value="CDC45"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="203"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="427"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="589"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="741"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="793"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="206"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="589"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="751"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="793"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="805"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS21196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="894" mass="99310" checksum="D9593D41783AC6E0" modified="2011-10-19" version="1">MHLPRSLISKPYLHLLNTRHPLSPPVLILVALEPDALCACRILTRLFKHDYIPHKIQPVAGYADLERVGRELVAPMMETRGGSGGVVVCLGVGGMADLGTILGLEPDEEVEGAEGLETQAYAGVEVWVIDSHRPWNLSNVFGGFPLEPETEEAKTFAARSPPGVNGGRIEQSYRHGKGGIIVFDDGDIEDELGKEREAYLALVDMPEVEDDGEDLGDSDDDDEEDDDSNDSENSGDEPPTLPAPPAGKKRKSWDFEEDDDESDDEDRPRQRRRSNSSTPIPDSPQRPAQRSLLSLRGDRDEPIFSSDPLEPPSAAQPPKQPSARTLRRRLLRSRRKNEDILREYYRLGTSYSEPVSSMLYSLASELGREDNDLLWMAIVGVTSMELYGRSSAGIAVPARGSESRPGSGWLGMRGARIRQLLRDEVRRLNPPDPTKPENVGIIPTTARSPEDTSIRLSPEPKFLLIRHWSLYDSMLHSPYLFSRLKTWSESGLKRLHKLLAKMGVSLVQCKQSYTHMDMVLKRELRTKLLKYASLYNLDELVPTIDTDGPDRGGSKDGWGFVRSWGWRATLSAQDVGVVVGALLEVGKSPPGLSSSPEPGATQSPQDVIPAGVDSNPSEEWLPRFWEAYDALEDIEALKAGLPTAQYLHKAIFTTGTTILKKKQITHLRAFRMCVVKSGTAPDAALFNHPGALTKLALWIGEALAEQEKEATGGRLAHGGRGTPLVVASLDEKRGVYVVVGTGGGGGPDTTFLDREAAKKRAKLKQEKEERRKVKEKLKQERREARRRLKLEEKRKKREEEGKGDEYEDEEDEDVTESEEETSSSEEEEEEEEEEEEIERGRGYGLNRFGVAFQDVVAETNARVRIDSFEHCVVEVKKEDLGGFLESLSMKAVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>G0S3W6</accession>
    <name>G0S3W6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0039130</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS22028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694324.1">
        <property type="nucleotide sequence ID" value="XM_006694261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S3W6"/>
    <dbReference type="GeneID" id="18257951"/>
    <dbReference type="KEGG" id="cthr:CTHT_0039130"/>
    <dbReference type="HOGENOM" id="CLU_2196652_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS22028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="108" mass="11143" checksum="D7C7D63E4D451C67" modified="2011-10-19" version="1">MLLLLPAEPEALASSSSPSNAASPSPSPLRGTELAGDELELDSIWIRSVGNKASGRNPGPNPGPGLGLRAPSDRPRLGQGREPLCHPGGTNAVWGIEVVGFELEDLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0S453</accession>
    <name>G0S453_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DUF221 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0030740</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693523.1">
        <property type="nucleotide sequence ID" value="XM_006693460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S453"/>
    <dbReference type="GeneID" id="18257112"/>
    <dbReference type="KEGG" id="cthr:CTHT_0030740"/>
    <dbReference type="eggNOG" id="KOG1134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009187_1_0_1"/>
    <dbReference type="OMA" id="VVCAWAF"/>
    <dbReference type="OrthoDB" id="2150324at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF149">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="480"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="524"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="597"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="655"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="679"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="10">
        <location>
            <begin position="37"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="11">
        <location>
            <begin position="207"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="386"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="832"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="952"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="954"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="967"/>
            <end position="977"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS21227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1030" mass="114739" checksum="92F2356862A000CF" modified="2011-10-19" version="1">MDTARLLQERDGQKSSAEILLQLLSDPFASQLQQSSVYAALGSSLGITAAIAIAFSFLRPYNSVVYAPKLKHADEKHAPPPLGKGLFAWISPLWSTSEEDLVHLAGMDAAIFMRFTRMCRNIFVILSVLGCGILIPVNWTNFTPPDPSWLYQVTPRNVWGAPLWATVVFAWLLTLIVCGFLWWNYRKVLQLRRTYFKSEEYQQSLHSRTLMLYDIPKSYTSDEGIARIIDKVAPHSSFARTVVARDVKVLPALLEEHEKTVRKLEKVLAKYLKDPNNLPATRPTCLPSKKDPSYSSYPKGQKLDAIDYLTQRIKTLELEIKDVRQRIDKRGSMPYGFASFADIAEAHAIAYACRKKKHGAVVTLAPRPNDIIWDNMPLSSTTRSTRRLWNNLWITILTILWIVPNAFIAIFLVNLGNLGNVWPAFKRSLERNGTTWSLIQGIASPALMSLVYVALPIIFRRMSIKAGDQTKTGRERHVVAKLYSFFVFNNLIVFSVFSALWSFIANVVQRTESGADTWKAIVDSDFGLTVFLSICTVSPFWISWLLQRQLGAAVDLAQLWTLVYSFAMRKFSSPTPRELIELTAPPPFDYASYYNYFLYYSTIALCYAAIQPLVLPAAALYFCIDVGLKKYLLLYVFVTKTESGGMFWRILFNRFLFASILSHMVVFLVVWVRGDASHVQAYAVAPLPFLMIAFKIYCSRAFDHKIQYYATRYTRQDQMEAAKNFKEQGLCTDKLLAARFGHPAIFKPLITPMVHAKAQNLLASIYRGRPGDGYDGDTMSVSGYSDSYALDNMSSGQAGKTSPSIPGFEVVPESRLDFEFYKNRDEFAADHGAGELFGRPSDIIRPDTPGMPGSEPNSRPGTPAGGMGFAGRRAFSPYTDDVGSSYRTPQQYSPYDEPSHYSSAARHHPTNSYSRAGASGNTLYGLGSGSNDSGANLVINAAGMPISNPGYRSHTPSSYSSTRAPGMLGGGPRGYGGLPQTDHDEHMAPQSYDYFRGSNNRRRPGEASETGRATPPGAAPRSGGHIWGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G0S473</accession>
    <name>G0S473_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mucoidy inhibitor-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0030960</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693543.1">
        <property type="nucleotide sequence ID" value="XM_006693480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S473"/>
    <dbReference type="GeneID" id="18257134"/>
    <dbReference type="KEGG" id="cthr:CTHT_0030960"/>
    <dbReference type="eggNOG" id="ENOG502QWQ0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010457_1_0_1"/>
    <dbReference type="OMA" id="CRINNTK"/>
    <dbReference type="OrthoDB" id="10068793at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011935">
        <property type="entry name" value="CHP02231"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037291">
        <property type="entry name" value="DUF4139"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025554">
        <property type="entry name" value="DUF4140"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02231">
        <property type="entry name" value="mucoidy inhibitor MuiA family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31005">
        <property type="entry name" value="DUF4139 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31005:SF8">
        <property type="entry name" value="DUF4139 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13598">
        <property type="entry name" value="DUF4139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13600">
        <property type="entry name" value="DUF4140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4140" evidence="3">
        <location>
            <begin position="19"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4139" evidence="2">
        <location>
            <begin position="306"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS21247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="784" mass="87032" checksum="B17D0FB7AB560174" modified="2011-10-19" version="1">MEGPHKQEFHVRDLPTRSVTLFPNRAQVVREIKNITLKPGANEVTVVGLTPTVDEHSIKVEGTGSATITDMTVELLPNRDIFEDIYPDSDTDSESNESSDSDDDDDKPNSALEEVRDKLVALHDELTRAEEIMSSADQRLRALDAYISSFNQPRKEAVMIDTELAIYRKEREKLFEERQQGLVRSRQITKDIDKLRREEERLERIEAKERAKAEKERAKIQRAKEKEREKQQRRKEEKAKEKARIRKERENFWPRCCYTVRITLDATIYSPVSSRRNSIASGTEVVKAVPEKEIIDDASAVTFCDLALSYVTSSAFWSPSYDLSLSTTNNTAVLCFDAHLTNMTSETWTNTRVTLSTSQAKFSGLQDEIPTLTPWKLRIVGKGGPWDGNDIAYSREEQHEKELWNAAQQMASQPKARANLFGISKPPVSVAASQAAASNLAAGPAPPPQDYPIASRPPLQSRAPEIQQIFGAPQAQNKKAERFVKLSAKSPAPPGTMLSSSSRARCGDDYTRDLAIYGTAEAVFGTEAEADTILEPAPEVTFQESSFEETGLTATYDLPNLKTLKPSSTASKQRIARLSFTNVTFTRTVVAKYKPAAYLKARLRNTSKLTLIKGPTGLTLDGTFLGRSTLPRCSAGDTFSMMLGIDPAIKVAYPKPDVTRSTSGVFVRGENTMYQRTITLINTRATSGKPVNLTVLDQVPVSEDEKIRVEILHPKGMQIGGRGVATGVAGREGKEEQEWGKAYAVLKKAGEVSWDVTLNAGKSVKLLLQYEVSFPSGERVAQCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4H1</accession>
    <name>G0S4H1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0022800</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692745.1">
        <property type="nucleotide sequence ID" value="XM_006692682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4H1"/>
    <dbReference type="STRING" id="759272.G0S4H1"/>
    <dbReference type="GeneID" id="18256318"/>
    <dbReference type="KEGG" id="cthr:CTHT_0022800"/>
    <dbReference type="eggNOG" id="KOG1210">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_576354_0_0_1"/>
    <dbReference type="OMA" id="MVANAMN"/>
    <dbReference type="OrthoDB" id="4174112at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022190">
        <property type="entry name" value="DUF3716"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051574">
        <property type="entry name" value="ZnF_E-box_Homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24391:SF18">
        <property type="entry name" value="EG:115C2.6 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24391">
        <property type="entry name" value="HISTONE H4 TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12511">
        <property type="entry name" value="DUF3716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="176"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="259"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="537"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="180"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="259"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="537"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS20449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="592" mass="62248" checksum="29B1AE9EB10A2CB5" modified="2011-10-19" version="1">MKPAVVRSQQQQQQQQQQQQQQQQQPQQPQTQRGRANKVTKPTAPARARPSASAAAARQAAAEAAAEAAAVQAQQVNQVAIGPDGQPTGLFDDVNANLNAANLNVSVTMPGAENYGAPAAMDTDMNEDAHGDAEADADMDDAGAAAAAAAAAAAASGLGPHVDLTAANILANGGPGPAGNGIPQDPALQDMQQAAQAAATGYSQQQLHHQQVQQARQHQVQQHQPPAQMGTPQQLQQQIPQQMQSAAAAAAAAAAAAAAHHQQQQMQPVQQAPMQQVQQQPQPTMQQVQHQHQQPAQQPQQQPAPNPGGPLMKTTEEIARESALANGYRDLPVESALAKRLAREPGQRLAQQRRPEQTLNLARRSNVEALFAQIAGEPARVPCKNCHKGHGPWTTCIVVDGQMCGSCANCWFNASGARCSFHETRNPQLHAQNAAALLPTGPAALGTAADPAYRYGSYLRSGSAVTANAAALAQANANGAAALLASSPVLQQMVANAMNEVRAADAVTRQLIKMDITAKQLALQMLEYEELVAASAGHQNQQHQGQGQQVQDHQHHQQVQQAQQQQPAPMQVYPAPPQQGQVNLGGEQTAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4J6</accession>
    <name>G0S4J6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0031240</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693567.1">
        <property type="nucleotide sequence ID" value="XM_006693504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4J6"/>
    <dbReference type="GeneID" id="18257162"/>
    <dbReference type="KEGG" id="cthr:CTHT_0031240"/>
    <dbReference type="HOGENOM" id="CLU_2830993_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="66" mass="7632" checksum="280BF1D6363C0FC2" modified="2011-10-19" version="1">MPSKTTQHHCVQCKGAARRAEKLQRLEKEQARRASQESTNDGVGQLKLKSKRSKKKDRKKEKRSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0S4T1</accession>
    <name>G0S4T1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0023420</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692806.1">
        <property type="nucleotide sequence ID" value="XM_006692743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S4T1"/>
    <dbReference type="STRING" id="759272.G0S4T1"/>
    <dbReference type="GeneID" id="18256380"/>
    <dbReference type="KEGG" id="cthr:CTHT_0023420"/>
    <dbReference type="eggNOG" id="KOG0823">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1372041_0_0_1"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045103">
        <property type="entry name" value="RNF5/RNF185-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12313">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="112"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="47"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS20510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="199" mass="21596" checksum="0403FF6844F02B5B" modified="2011-10-19" version="1">MYAFSGRFSSSAGNAAQQSGQQSFGNISGRMMRNTALAQAMGHDPTFFESSRTISPASGSTKRKREDAGEDGRAMDDEALLNQDVVDLVDTDEVPAGLLKPKEYTKLSGFQCVICMDKCTNITVTHCGHLFCSECLHSGLNIHPNKRVCPVCRQKIDKLPQNGRFGPKAKGYYPLELKLVSKKMLAKGETSKAKGGTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0S511</accession>
    <name>G0S511_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative amino acid transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0023690</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692832.1">
        <property type="nucleotide sequence ID" value="XM_006692769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S511"/>
    <dbReference type="STRING" id="759272.G0S511"/>
    <dbReference type="GeneID" id="18256407"/>
    <dbReference type="KEGG" id="cthr:CTHT_0023690"/>
    <dbReference type="eggNOG" id="KOG1303">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009646_8_1_1"/>
    <dbReference type="OMA" id="PMGIKYA"/>
    <dbReference type="OrthoDB" id="655540at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF692">
        <property type="entry name" value="TRANSMEMBRANE AMINO ACID TRANSPORTER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="422"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="509"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="548"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="614"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="637"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="671"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="287"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS20536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="705" mass="76485" checksum="5A6515450972075F" modified="2011-10-19" version="1">MTTRNNPTTWDQYERGGFSRTGSTTSLNRSGQFETESLLGRSVDSRHGDDEWVQALRQRRSSFTSRLAGLTEIGGVNSIRNFTRSWQRAAGFTEVIPQRPSFIFAADQAPIVPLPSGDGVEPDVEATLSPVRTVSSSPRGSPSLIRQQLEAAVGQQPQQPSPRALSPEPTSYPLYRTSSHENYKALLESDLTPAFRVGSHTSRASDLGSIFAIPPHLATPSIVGSYGSAIDYGTIRSNISRPSMAEAAAIWHQQQEVAGAPADSELPPILVKEVEQDGKIVLTVEGQSTLPQTVFNSTNVLIGVGLLSLPMGIKYAGWLCGMISLFLCAAVTAWTAKILARCMDLDPSLITFSDIAFISFGRKARMATSILFTLELVAACVALMVLFADSLALLFPGVLSVTGWKIVCALILMPLNFLPLRLLSFTSVIGIFSCLTIVLCLILDGFIKPTSPGSLLEPAKTYLFPSNWLTLPLSFGLLMSPWGGHSVFPNIYRDMRHPYRYNQALKITFSFTYLLDTTTAVAGLLMFGDEVRDEITSNILVESSYPRALTALMCLCISIIPLTKIPLNARPIVSTVEVLSGLQQQLVDHHGMGHGTGDDSGGGSSVTAAAFWRVVIRLAVVLTFLVISILFPAFDSIMAFMGSALCFTICVSLPLAFYLKLFGHELSVRERIFATTVMIISIVLSIIGTVWAFLPKSLIGAETEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G0S543</accession>
    <name>G0S543_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Adenylosuccinate lyase</fullName>
            <shortName evidence="12">ASL</shortName>
            <ecNumber evidence="6 12">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0024020</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = fumarate + AMP</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="6 12"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692864.1">
        <property type="nucleotide sequence ID" value="XM_006692801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S543"/>
    <dbReference type="STRING" id="759272.G0S543"/>
    <dbReference type="GeneID" id="18256440"/>
    <dbReference type="KEGG" id="cthr:CTHT_0024020"/>
    <dbReference type="eggNOG" id="KOG2700">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030949_1_1_1"/>
    <dbReference type="OMA" id="VQENAMK"/>
    <dbReference type="OrthoDB" id="406045at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03302">
        <property type="entry name" value="Adenylsuccinate_lyase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.60:FF:000001">
        <property type="entry name" value="Adenylosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000005">
        <property type="entry name" value="Adenylosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172:SF1">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adenylosuccinate lyase C-terminal" evidence="13">
        <location>
            <begin position="373"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS20568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="482" mass="54502" checksum="683D32005C4A1287" modified="2011-10-19" version="1">MSSYDKYQTPLSTRYASQEMMTIFSARERASTWRQLWVWLAEAEKELGLPIPDEAIEQMRANVVVSDKAFAVAREYEAKFRHDVMAHVHAFGEDAPAAAGHIHLGATSCYVTDNADLIFQKRALDLILPKLAKVIKNLQEFALKYKDMPTLGFTHYQPAQLITVGKRACQWIQELMMDLEDIETARDRLRFRGAQGTTGSQATFLELFKGDASKITQLNEILCKKAGFPSCYPISTQTYTRKVDLRVANAVCALGATAARICSDIRHLANLKEIEEPFEKTQIGSSAMAYKRNPMRSERITALGRKLARLPADFTATFETQWFERTLDDSAIRRMDIPEMFLLADSILLALDNVTNGLVVYPNVIRAHIDQELPFMATESILMKLSTHGISRQDAHEEIRVLSHQASDVVKQQGGKNDLLERIKRTEFFKPVWDEIDNLLDPKLFIGNCPKIVEDYCNGEVAEKLAKYKDALDKAETAQLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0S601</accession>
    <name>G0S601_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CTHT_0025530</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693013.1">
        <property type="nucleotide sequence ID" value="XM_006692950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S601"/>
    <dbReference type="STRING" id="759272.G0S601"/>
    <dbReference type="GeneID" id="18256591"/>
    <dbReference type="KEGG" id="cthr:CTHT_0025530"/>
    <dbReference type="eggNOG" id="KOG1152">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004134_0_0_1"/>
    <dbReference type="OMA" id="MDESECR"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045719">
        <property type="term" value="P:negative regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14004">
        <property type="entry name" value="STKc_PASK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000320">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000314">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057213">
        <property type="entry name" value="DUF7891"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF51">
        <property type="entry name" value="PAS DOMAIN-CONTAINING SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25421">
        <property type="entry name" value="DUF7891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="991"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="330"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="483"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="809"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="859"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="923"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="338"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="530"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="810"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="883"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="923"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="936"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="963"/>
            <end position="976"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGS20717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1260" mass="139164" checksum="278623B8F8097153" modified="2011-10-19" version="1">MRGTYGSHPDNGDNDTRDDAEAPSSLQPQQQQLVPSLQIPKNRSTGNLGSLNDPADKAGHSRFSFVADSSLHPALSPEYDPRLSSARSPIMNEHDHGLGMSGLRRIRQQLPLRTPTLPSSTLSRSPSLVNLATRSSSLSLTDLQQIPTAASVPVSPAFTEDLSRFPSESLHSFSFANQTDDLLHNRQTLLKRSLEFMKDRMGWSVSSAAVASAQARVSGDPEMQGMMDVLAQAQMFGSGNDIQGRSRLPMGPSTDPAITPNEGNVFDKGFAPRTASPESIDRIPLLASPATLPASGLSIVAPAPAQEKEGCEDMSDPPSLPTVHKISEEAIESEGSSRTPTNESGTTAQTSPPASRRESMLKRAMTDTVNLSMEQRLRDALAHPMTSEPLKAQQPVSAQLLSSASVSSKALAAPVPGHTTRWVPAAQAIFTTESKPPWTILAANDLACLLFGVTKAEVRKMGILEVIQEERRAWLVNKLQQGLQNDTKESPEEEPSPPTPAVDTSKLLGSRNGGITAKLLSKPNSRALKAKTDRRPATIHSGDPKPPRPGNPHHTSNKSRGVLLCGDVVPIQKRNGATGSASLWVKEKRVGLIWVMEEIHEDVAYIELDEEGIVTKLSGALGPIWGNEHPKSGMDVGQLIPRIPRQGIDPHSGEVDYMEIAKKKHYTCRNADDMHLPATVEQIRGTTQLRVSSFPHIAGMIVVDPETLHIKSSNSVFCGALFGHEKPDGKSINSLVPNFENLLRILTEEERIELVEGMVVPEHSFRKAYTLLAIKENHPDAAQLFMHCDGIPARHRDGSQLKVDVQMRVAKSEKKVSKRDQKDGDSDGESSTSEAGDEFVVSETEWVYALWVTYSRQVHSTRPDKGISSPLMSGMITPLHQPSPGQTQPVHSPQEIQFDSEEQPKSERAPLLAENATQIVGSTAQVPSTNPPAQENPEKQPGEEQQKEQQKEKRKEDKKEPDQQLQQQQTTPAAQQASEPPVKKKKTIDDFQILEEMGQGAYGQVKLARYRSTGKTCVLKYVTKKRILVDTWTRDRRLGTVPLEIHVLDFLRRDGFKHPNIVEMQDFFEDEINYYIEMVPHGLPGMDLFDYIELRTNMEERECRSIFVQVARAVHHLHTKALIVHRDIKDENVILDGTGQIKLIDFGSAAYIKSGPFDVFVGTIDYAAPEVLAGRPYRGKEQDVWALGILLYTIIYKENPFYNVDEIMDRDLRVPWTMSDESIDLIRKMLNRNVSQRLDIEGVLAHPWCQGVEMVAAQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6C8</accession>
    <name>G0S6C8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Carbamoyl phosphate synthase arginine-specific small chain</fullName>
            <ecNumber evidence="3">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Arginine-specific carbamoyl phosphate synthetase, glutamine chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Glutamine-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CTHT_0034460</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CarA family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="3"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693879.1">
        <property type="nucleotide sequence ID" value="XM_006693816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6C8"/>
    <dbReference type="STRING" id="759272.G0S6C8"/>
    <dbReference type="GeneID" id="18257484"/>
    <dbReference type="KEGG" id="cthr:CTHT_0034460"/>
    <dbReference type="eggNOG" id="KOG0370">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035901_1_0_1"/>
    <dbReference type="OMA" id="CFSVQYH"/>
    <dbReference type="OrthoDB" id="434at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005951">
        <property type="term" value="C:carbamoyl-phosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000016">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific small chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.20:FF:000003">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific small chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="entry name" value="Carbamoyl-phosphate synthase small subunit, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009475">
        <property type="entry name" value="PRK12838.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF4">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE ARGININE-SPECIFIC SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="Carbamoyl phosphate synthetase, small subunit N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbamoyl-phosphate synthase small subunit N-terminal" evidence="15">
        <location>
            <begin position="54"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGS21583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="454" mass="49766" checksum="2402392F10D5055D" modified="2011-10-19" version="1">MFSRLAARLPFKAMGHAARLPSQTRFASKLTVSGSKGRTMPATNTRTTAPASGVNATFTIRDGPVFHGKAFGANINISGEAVFTTSLVGYPESMTDPSYRGQILVFTQPLIGNYGVPSNERDEYNLLKYFESPHIQCAGIVVADVAEKYSHWTAVESLAEWCAREGIPAITGVDTRAIVTYLREQGSSLARITIGDEYDADEDEGYVDPGQINLVKRVSTKAPFVVNNPNARYHIALIDCGVKENILRSLVTRGASITVFPYDYPIHKVADHFDGVFISNGPGDPTHCQETVYNLARLMETSSAPIMGICLGHQLLALAVGARTIKLKYGNRAHNIPALDLTTGQCHITSQNHGYAVDASTLPSEFKEYFVNLNDGSNEGMIHKTRPIFSTQFHPEAKGGPMDSAYLFDKYLENVEMYKASAKVYRDNRPSQLMIDILSKERVGVEPTPLANYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6M0</accession>
    <name>G0S6M0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methionine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Methionyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CTHT_0026690</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="3"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693127.1">
        <property type="nucleotide sequence ID" value="XM_006693064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6M0"/>
    <dbReference type="STRING" id="759272.G0S6M0"/>
    <dbReference type="GeneID" id="18256707"/>
    <dbReference type="KEGG" id="cthr:CTHT_0026690"/>
    <dbReference type="eggNOG" id="KOG1247">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009710_3_2_1"/>
    <dbReference type="OMA" id="HLNTTEY"/>
    <dbReference type="OrthoDB" id="5844513at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000031">
        <property type="entry name" value="Putative Methionyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="entry name" value="Methionyl-tRNA synthetase, Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="METHIONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="Methionyl-tRNA synthetase (MetRS), Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13 17" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="15">
        <location>
            <begin position="17"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl-tRNA synthetase anticodon-binding" evidence="16">
        <location>
            <begin position="459"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="612"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="612"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGS20831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="676" mass="75424" checksum="C3D2FD0D978FE44D" modified="2011-10-19" version="1">MPAPRKPALPQPGKDNILITSALPYVNNVPHLGNIIGSVLSADVFARFCRARNLPTIFICGSDEYGTATETKALSEGVDPATLCAKYHAIHKEIYDWFRIDFDIFGRTPTPEHTEIVQSIFAGLWKNGYIEERETTQAYCPTHDSFLADRYVEGECSICHDKGARGDQCDACGNLLDPLEPDSNGSDGHEVRATGWLINPRCKLDGTTPERRKTKHLYLRLDALQEELRPWLASVEKNWSANCVAITHSWLEKGLKPRGITRDLKWGVPIPTGLPGLNDEDYAKKVFYVWFDACVGYPSITKTFTDAGNPEGKNWEKWWKNPDEVSLYQFMGKDNVPIIFPASQIGTRENWTKVKHFSTTEYLNYEGGKFSKSKGVGVFGNNARDTGIDADIWRYYLLSRRPETSDAEFKWEEFVDANNNDLLKNLGNLCQRVVKFCQARFEGVIPEFDISAFPALEQHRQEVNKLLQEYITQLRGLKLRAGLSTVMSISALGNKLLQDNKLSNQLLAEEPARCAAVIGLALNHLHLLANVLTPYMPAKAQSILRQVGLKPAEGEDLVPVYIPDTWEANTLKAGHTIGTPELLFSTIPAAKIEEWRDAFGGEELRKQKALEAEKAAAKKAAREKEKEKKRLKKEKAAQEKAAQEGAAKSAEGKQEGAPAQATELPIRSAPIDGQAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0S6R9</accession>
    <name>G0S6R9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0035370</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693967.1">
        <property type="nucleotide sequence ID" value="XM_006693904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S6R9"/>
    <dbReference type="GeneID" id="18257575"/>
    <dbReference type="KEGG" id="cthr:CTHT_0035370"/>
    <dbReference type="eggNOG" id="ENOG502SNS3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060131_2_0_1"/>
    <dbReference type="OMA" id="DANPEHM"/>
    <dbReference type="OrthoDB" id="4738875at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS21671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="253" mass="29178" checksum="14ACB7F827BD3224" modified="2011-10-19" version="1">MKPRRAEPSDIEAITKVHIRTMPLDPQWNYRFPYRNEHPEDHYKYTKMLLEYFLDPSYDDWLVMVVEDSLEPGGPTEIVSFGVWDVSYVNKRRYGPGYKTQDRKCHFQGPCAAKRGGGSRRDANPEHFKAFSQGQKKAYQKYFAPIGPEQIHLQILATLPEYQRRGHASSLCRWAMELVCQEGLKDMSVMASPMGYELYKSLGWDVVGTFWIQVPGEEEKLVLRAMMYKPPKLEGSSDSEEEVQVANGRCAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7A6</accession>
    <name>G0S7A6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mannosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0036170</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694046.1">
        <property type="nucleotide sequence ID" value="XM_006693983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7A6"/>
    <dbReference type="STRING" id="759272.G0S7A6"/>
    <dbReference type="GeneID" id="18257655"/>
    <dbReference type="KEGG" id="cthr:CTHT_0036170"/>
    <dbReference type="eggNOG" id="KOG2515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018152_0_0_1"/>
    <dbReference type="OMA" id="PRDMHAK"/>
    <dbReference type="OrthoDB" id="497541at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF2">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE ALG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS21750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="603" mass="69120" checksum="8038EC844E82B4B7" modified="2011-10-19" version="1">MAQEQTDKSSAKPTKREFIHPSAKHARKKAIRNAFAIEPISAFYMFLGANMIAALFSPIQDCDETFNYWEPAHYLSHGYGLQTWEYSPDYAIRSWLYIGIHAIGANIRRLLPHSNKVSEFYFLRYLLAFACALCQTLMWRAVCLALNPRIGLFFILALVFSPGNFHSSTAFLPSSFAMYMAMLGAAAFINWRGGIKTSQGIFWYAVGGMLGWPFAMALCAPFVLEEVFFAMISDKEGVFESCIRLFRGAVATLLLVAFDTVINLYFYKKWEIVPWNIIKYNVFSSSGGPNLYGTEDWTFYFKNLLLNFNLWFILALLSLPLFLLQKLLFRRSTAETAQSGLRTLVILSPFYMWLAIFTLQPHKEERFMYPAYPFLALNAAMALHTFLAIIGNADPKTLIGRVPAKAKLAVVVTGILLAIDFGLARVWGIYSGYHAPLDIYQPLAEVGGRGDTVCFGKDWYRFPTSFFLPRDMHAKFIRSEFRGLLPGEFSEARTGFGFWSGTWLPTNGLNDRNEEDPSKYVDLSSCVFLVDTQYPERKDEELPVNEPDYAKDVNRWEVIKCEPLLDAERTHFFARALWLPDWSIVPEKYRRKWGRHCLLKQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7J4</accession>
    <name>G0S7J4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">glycogenin glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.186</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CTHT_0028360</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Self-glucosylating initiator of glycogen synthesis. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = alpha-D-glucosyl-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23360"/>
            <dbReference type="Rhea" id="RHEA-COMP:14604"/>
            <dbReference type="Rhea" id="RHEA-COMP:14605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140573"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56560"/>
            <dbReference type="Rhea" id="RHEA-COMP:14606"/>
            <dbReference type="Rhea" id="RHEA-COMP:14607"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140574"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyltransferase 8 family. Glycogenin subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.186" evidence="10"/>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693292.1">
        <property type="nucleotide sequence ID" value="XM_006693229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7J4"/>
    <dbReference type="STRING" id="759272.G0S7J4"/>
    <dbReference type="GeneID" id="18256874"/>
    <dbReference type="KEGG" id="cthr:CTHT_0028360"/>
    <dbReference type="eggNOG" id="KOG1950">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017171_2_0_1"/>
    <dbReference type="OMA" id="MVHFIGP"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008466">
        <property type="term" value="F:glycogenin glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000092">
        <property type="entry name" value="Glycogenin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="353"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="471"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="629"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="395"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="421"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGS20996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="682" mass="75270" checksum="1F71E11CBE51AF99" modified="2011-10-19" version="1">MTVQTKGEDVYASILLTDTYLPGALVLAHSLRDAGTKKKLAILVTPDTVSPEVITQLKASTLNQTVYDYIIPVERIRNDHPANLYLMNRPDLHSAFTKIALWKQTQFRKIVYIDADVVAYRAPDELFELPHAFSAAPDIGWPDIFNTGVMVLSPNMGDYYAMMAMAERGISFDGADQGLLNMHFKNSWNRLPFTYNVTPSAHYQYVPAYLHFQSSISMIHFIGADKPWKLGRSQHVGNNPYDEMIGRWWAVYDRHYHPNANNVPDIVRYFVKGEFDPTKSFVLGANGSWDAQKNPPPPYSKPEGYNLPQTYYAMSSDPTPFVTPDSAHYENTPKPIFPWEMNRSRPKRVFGGYVESEPAPATTPAPKATPKPVATPRARSPVRSSTPKPSDSDTPRTPSPARRATPGPTPSSARSDAWNSATPTATPGTTATTPVAQHHSSVWNRFTNVWDDIPEITRYIEALQSRYRRSRSRSNVNPTGTTKVTEFPSEDERPSLPVTPAPIKRTGSRAGTIGRVLSYGEDEKAFAATVPSAPQEWVCVHGVQWSPADCPCELLQKANNLLPGREFGAEPVHHKLIEKAEPERADTATPIVSPMPVKPVVTTVVGKGLEPSPVDRILSIGNEEEVPASPTIAESWASRPGSTVPLPSYAGPGPMFEKGEVLPMHAVGSALPSDEVREELDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>G0S7W6</accession>
    <name>G0S7W6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0037240</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694149.1">
        <property type="nucleotide sequence ID" value="XM_006694086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S7W6"/>
    <dbReference type="GeneID" id="18257762"/>
    <dbReference type="KEGG" id="cthr:CTHT_0037240"/>
    <dbReference type="HOGENOM" id="CLU_2072869_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS21853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="118" mass="12607" checksum="FF40D806FA4546F0" modified="2011-10-19" version="1">MPGSGTQQGSVPLADNELTSSLLTFPKLYQRAPSNPSGTGHSDLAPSSATTTQAAESPATARAMEYTGAWKPSLERSHQSWSVQEFKHEVQLREAAVPEDRIAEAPSKGLPLGFSEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G0S876</accession>
    <name>G0S876_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar protein sorting-associated protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0037840</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the VPS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694206.1">
        <property type="nucleotide sequence ID" value="XM_006694143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S876"/>
    <dbReference type="STRING" id="759272.G0S876"/>
    <dbReference type="GeneID" id="18257822"/>
    <dbReference type="KEGG" id="cthr:CTHT_0037840"/>
    <dbReference type="eggNOG" id="KOG2273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028982_0_0_1"/>
    <dbReference type="OMA" id="FYLGTME"/>
    <dbReference type="OrthoDB" id="9976382at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030905">
        <property type="term" value="C:retromer, tubulation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06891">
        <property type="entry name" value="PX_Vps17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000046">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000034">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014461">
        <property type="entry name" value="Retromer_complex_Vps17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053055">
        <property type="entry name" value="VPS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037907">
        <property type="entry name" value="Vps17_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011791">
        <property type="entry name" value="Vps17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="7">
        <location>
            <begin position="163"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="523"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="582"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS21910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="643" mass="70607" checksum="B7C4E773FFD7CD02" modified="2011-10-19" version="1">MDYSSSIHDHDQSEAAVWGGNDPQRSPQTRPLFGSEPPSSPFRYTAPSNGLHDEGGFGAGDSRDRTYDDSRRPETESTSLHAEEPGPIEPLPEPERQGEQQGPTSKVAQPEPPQPPSPSAPAQQTTPQQAQAPPQPQPTSEPAPMQSPKQQRQPRKAPPPQFKLQAKVTGIERTGRKDPIIRFDVYTNLPAFRTTQYRDVRRLHSEFQKLAEHLISANPEAIVPAVPPAVTSAGAGTEEDELRVKALMQRWFNYVCSNEVLMRDDEMVLFVESDFGYSPMVKKKQPATGVRRKILKQFAPPPDDTPELQEARPIVKLFYLGSLDASHKLDRLVKSRRGLGLTESDFGVKLAQMNVQEPHPGLANAYRKLGKIIQTVGDFHAAQATAEATTLGDPLQYHSSDAFIVKETLTNRQILIREFLQAQDTTRSRLNAADRLKASSSVRREKVDEALAALDEARHAEEALYQKTSRVTQNLVQERRRWFARTSADLRASIREYVLRQIEAERRTLALLESVRPDIRSIDGSGGLSRLGRENHPVAPRRSSLQASQGPKGDAWSGVPRRSDAVLGRASVATLVTAGLGLGGIPEEDGTGDGEDGRRARSLSGVGYGVGIGGPLAGLVAEEDDEDRVDARNAASRLAQSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8C8</accession>
    <name>G0S8C8_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative heat shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0021290</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS20303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006692599.1">
        <property type="nucleotide sequence ID" value="XM_006692536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8C8"/>
    <dbReference type="STRING" id="759272.G0S8C8"/>
    <dbReference type="GeneID" id="18256167"/>
    <dbReference type="KEGG" id="cthr:CTHT_0021290"/>
    <dbReference type="eggNOG" id="KOG0710">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046737_1_1_1"/>
    <dbReference type="OMA" id="RSAMSHW"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="61"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="111"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="180"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS20303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="257" mass="28986" checksum="2569E3A2E6F33350" modified="2011-10-19" version="1">MMSIFPATFYDYTPAVEASFTPLFRLLDDFDAYTRQMQRAAAPNCCPRHLMRSPRHNHTNNAVTTFNPRFDVCETETAYELHGELPGLERENVSIEFVDPQTLVVKGRIERGYEEGSPEGEEETNDTKSGNTAAQEMETPRRNSFQATVEDDPEDPHHTPAPSPKTVPADAAPSEGNNAEPKEEKAVVKKSDSKRAVQKHNGTRYWLWERSVGEFQRVFAFPERLDHDGVTARLENGVLSVNVPKAKKAGKRKIEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8D9</accession>
    <name>G0S8D9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Required for respiratory growth protein 7, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0029540</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693409.1">
        <property type="nucleotide sequence ID" value="XM_006693346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8D9"/>
    <dbReference type="GeneID" id="18256992"/>
    <dbReference type="KEGG" id="cthr:CTHT_0029540"/>
    <dbReference type="eggNOG" id="ENOG502S6ZS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060368_0_0_1"/>
    <dbReference type="OMA" id="MCTKEGR"/>
    <dbReference type="OrthoDB" id="20734at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018828">
        <property type="entry name" value="RRG7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28133">
        <property type="entry name" value="REQUIRED FOR RESPIRATORY GROWTH PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28133:SF1">
        <property type="entry name" value="REQUIRED FOR RESPIRATORY GROWTH PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10356">
        <property type="entry name" value="RRG7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="34"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS21113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="32739" checksum="FF13FF70B4930B33" modified="2011-10-19" version="1">MRSSLFPSLLRAHTASTLLRRSFSAAATRLVADFSFPEDEHPDEALQPPKPPESQEPTSSTSLDPSPPQLQTTEPSQSPPKPQSRVDQPLIYPSPPSAPNHHDLPTFLEYASRTNLDPETSVYVGTLFEYTTCAALARYGFSLRRVGGVSDGGVDLLGTFSPPGVRKHASVPNLKVIAQCKAVRKPGPHLVRELEGAFASAPVGWRGSSGVLGLLVTGRPATRGIREALGRSSWPMAFVMCTKEGRVLQMLWNRRAEEEGLEGLGVTTRYYREEGGQEGKEVVLTWRGRNLPLAELGEGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8H9</accession>
    <name>G0S8H9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0029940</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988041">
        <property type="protein sequence ID" value="EGS21153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006693449.1">
        <property type="nucleotide sequence ID" value="XM_006693386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8H9"/>
    <dbReference type="GeneID" id="18257032"/>
    <dbReference type="KEGG" id="cthr:CTHT_0029940"/>
    <dbReference type="eggNOG" id="KOG1397">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008721_1_1_1"/>
    <dbReference type="OMA" id="FQMRTHH"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000026">
        <property type="entry name" value="Vacuolar calcium ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF14">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="148"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="307"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS21153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="469" mass="50681" checksum="DCC7A738CB12ABE2" modified="2011-10-19" version="1">MSSPSPPDGGPLQRHQTPPNTGSPDAVSSSPSPPTTSSPPPEKTTTNEKRTPSLPLHKGDLPDHEDTANLSFTQRLLRAFQVRSSGESGRTGIHPLHFLRIIFRSASWASRAVNILWPVVPAAIALRYASPDSHLAIFGVGVSMGGIVEIIMFIALITRENTASVDYVQVIQAAILGSVLATMLLCLGLCFIAGGIKREETHFSEAVSEAGSGLLLTAGFGLAVPTVFEHSLSGKITDTDELLSKTIDISRSTAILLIVAYFVYIFFQARTHHGIYDAVFHDDEQRDDDRHKESAKHRLTLTECCIALAVSITLVTIIAIALVDQIHYIVEERHVSDAFVGLILVPLVEKAAEHLTAVDEAYDNQMNFALSHVLGATLQTALFNAPFAVLVGWGLDKPMGLNFEVFDLVVLLLAIITVGNFLRDQKSNYLEGVLCVIVYISIAVAAIHYPNPHEINGAHGATTATGEHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8Q7</accession>
    <name>G0S8Q7_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">O-methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0039990</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988042">
        <property type="protein sequence ID" value="EGS20260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694409.1">
        <property type="nucleotide sequence ID" value="XM_006694346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8Q7"/>
    <dbReference type="GeneID" id="18258037"/>
    <dbReference type="KEGG" id="cthr:CTHT_0039990"/>
    <dbReference type="HOGENOM" id="CLU_180232_0_0_1"/>
    <dbReference type="OrthoDB" id="1535081at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS20260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="79" mass="8907" checksum="1F8B4CE26DE7959F" modified="2011-10-19" version="1">MGPKSRLIICDLVVLEWVEVGGFNVGYWLDLLMMARSGKERIVEEFRETLDRAGLELVKVWPSGVSLVAMVEGKLKGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8W9</accession>
    <name>G0S8W9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ESCRT-II complex subunit VPS25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0043710</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS25 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694765.1">
        <property type="nucleotide sequence ID" value="XM_006694702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8W9"/>
    <dbReference type="STRING" id="759272.G0S8W9"/>
    <dbReference type="GeneID" id="18258409"/>
    <dbReference type="KEGG" id="cthr:CTHT_0043710"/>
    <dbReference type="eggNOG" id="KOG4068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087657_0_1_1"/>
    <dbReference type="OMA" id="TRCLIMW"/>
    <dbReference type="OrthoDB" id="245150at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000141">
        <property type="entry name" value="vacuolar protein-sorting-associated protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.570">
        <property type="entry name" value="Winged helix' DNA-binding domain. Chain C. Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008570">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014041">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05871">
        <property type="entry name" value="ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS19880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="244" mass="27015" checksum="F3FC9435414CEF0B" modified="2011-10-19" version="1">MSDLQPQPQPSSSSSPPSSFTFPPEYHFPPFFTRQRNLTTHHAQLVKWSNLVLSYCRHHRILKLSMSGTSGFAMPSPNLTLPVVSSGGNSSSNNPGPYPPSLILGEVTAGSSVVEVDTSELFHNRKLNRRLALADIRSVIDFLRKDGRAEYVSTGKKEPSEGDLAWIYWRTPEEWAGLVEAWVDATGQRGSVLTVYELIEGDGTLGTEFHGLDQELLLKALNVLVKRGKAQIFGQEDSRGVKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0S8Z2</accession>
    <name>G0S8Z2_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0043960</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694788.1">
        <property type="nucleotide sequence ID" value="XM_006694725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S8Z2"/>
    <dbReference type="STRING" id="759272.G0S8Z2"/>
    <dbReference type="GeneID" id="18258434"/>
    <dbReference type="KEGG" id="cthr:CTHT_0043960"/>
    <dbReference type="eggNOG" id="ENOG502QRAF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038067_0_0_1"/>
    <dbReference type="OMA" id="KVGNAFH"/>
    <dbReference type="OrthoDB" id="2264563at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046868">
        <property type="entry name" value="BAR_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046869">
        <property type="entry name" value="SLM1/RGC1-like_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941">
        <property type="entry name" value="CYTOSKELETAL SIGNALING PROTEIN SLM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941:SF1">
        <property type="entry name" value="CYTOSKELETAL SIGNALING PROTEIN SLM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20400">
        <property type="entry name" value="BAR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20399">
        <property type="entry name" value="PH_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="364"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="481"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="197"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="25"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS19903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="550" mass="59723" checksum="650D44A494952423" modified="2011-10-19" version="1">MLKRFSTIRKDKEKEKDSSKSTDGAATEAPAAPTSTTATPAPAPTPAAATTEPAKMASQPTETPVSPVSPTATTRQSTLVSVASDEAVPETDPNTTAGLLAERLQAWKHAVIYLEEYFEAVEKLHKAQAKEYERVLKTISKPLREGDHFDQSLGGVAGFFENMRVNTQALINSNLETEKNIKGTALPIVERLHKEIKHKAKELAHGAEKAAKEVEKARNTTQKQIELLGQQTAAFEATGGKLGPTEDPYVVQRGVLHRLSKQVIEENNAHNDLISVQNNFETFEKHVVEVLHQAMETFNSFAGGQALKTQALFADMLGAAQRIPPNFEWNAFVKRAGDKLADPNEPPRTVEAITFPNMNHPSTKPLIEGSLERKSRNKLSFGYQTSYYVVTPSRFLHEFKDDDFHRRDPVPELSIYLPDAVLSTPQGEKFTVKGKDKSGHMGGKLAGTTELNFKAHSPSEAEKWYEALRKAATAQTVVEATAPAPTAEEKPKPVVAVAAPAPAPAEEKKPEPEPQESGITTVAPESAPVEEKEAAAAAAAPAEKVADTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0S928</accession>
    <name>G0S928_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0044320</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694824.1">
        <property type="nucleotide sequence ID" value="XM_006694761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S928"/>
    <dbReference type="GeneID" id="18258470"/>
    <dbReference type="KEGG" id="cthr:CTHT_0044320"/>
    <dbReference type="eggNOG" id="ENOG502QVFG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007968_1_1_1"/>
    <dbReference type="OMA" id="RRPTMDQ"/>
    <dbReference type="OrthoDB" id="2128042at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031606">
        <property type="entry name" value="Kch1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36424:SF1">
        <property type="entry name" value="LOW AFFINITY K(+) TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36424">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16944">
        <property type="entry name" value="KCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="404"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="650"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="808"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="874"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="895"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="910"/>
            <end position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS19939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="943" mass="104159" checksum="4A182FD7E21EEAE5" modified="2011-10-19" version="1">MGFLSHRRRNVEVLPEQKWDFISLNDFKHTSMGQPFAYAFLWFSLILSVVVYAVDIFTAYQLLALNKFTSQIEPDEIPFDIAKWIFSICIILSVVNLAYEYWRAITIMRRGSVAECFLDSLAARLESMRLGSGQGWKRFLVFAELTRSKKGIEYIALFTFFSFQSWIRVLFCAGPRQVINGFTIYSFYNKKLQIDSSSFEAGLSSFFDKIRALATQEPRQAVTLCGMLFTLIVWLFSFLSLLLAAFFFVFFLWHFIPREDGGLTGFCERKVNKRLKQIVAKKINTAMAEEERKRRKEALKAAKKKGEDRPVTMKPSLPVLKDDDLPSMPSISRTETFASFSEKASRPTTPGNFEMSPITQRPPMPSRTATTATAGSSSTYSSQAPLLSNAAEMGTSRPPGRTESPAPSMPSVAASRYPPSRVPTNASNYPPSRAATPASNGQSRSNPQPQRMMSNASSMVPRYTESPAPYSNEPIPSRPPPALSSAGPLGQYRGPVGPNPRWGPNNSGRRPAMDQYQGSNQPGRRPTMDQYQGPVQDGSRPTMDQYRGPSQYGRRPTMDQFQNHDPYGQRPTMDEYQNSTWDEGRPTMDGYGFLDPPMSPLGDRQPTLPNLEGGPFSQTSHNQWPSAVDREPKLPNLEELSRPGTAWDQELTSQSSRPTFDNYSNARASPAPSRFMPQDNNKSPFETSDDSRASPASSNLNAQAQGNDRTASDDYTTGRSSPAPSTFNPQDNSRSPLNTNTNGRASPAPSYFNPQAQSLDSSRRPFDASGGRASPVPSMSSSRYTRDGLRSLPSRRGSDEDRFRPMLRSNTALPSPSSEPRFAPPARSLTAPVSPTSTQQSQLLHHRQQSSDSGSSLMGAVLAAADGALRKESSSNSGQNQTQNQNQNPHAMTASNSNIDNIPSSSRGGSRAGGAGSGTWDGNDRNGNGNGWDQDLERGPRYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>G0S950</accession>
    <name>G0S950_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0044560</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694846.1">
        <property type="nucleotide sequence ID" value="XM_006694783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S950"/>
    <dbReference type="GeneID" id="18258494"/>
    <dbReference type="KEGG" id="cthr:CTHT_0044560"/>
    <dbReference type="HOGENOM" id="CLU_301480_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="683"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="892"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="685"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="919"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="934"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="953"/>
            <end position="963"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="991" mass="108816" checksum="15273C692975D42B" modified="2011-10-19" version="1">MARQLLRNALSPRERLPLGSLSNMTPVNAIPSEVTPKQLAKVLAADKNLLARVIANAPGELVEQLFVNSGLHVTQTARSILLVRNEDQNVEVQVTPPDSESAVAPKSTISTNQNHIDNYPVQAPFMNKKGSSVHRAAKSSVTNSSRQSEKAGMHTPENNTKRDQEAKGATASSHRTQINSNGDQKSVNSHYFTDVCDQHSRGQSIQHHSFAPRELHASSLKAPPRREPPVKLRLKTSWKSSDSTSHPDHVPKPSAPPAPQASHSEPVTSTSALAKPNDRTNYNDRRTDAYSKAEPLRHVPAPPIPSRATGLSFSDALKGKPFPRSSSPGVSRVEESAQRPNTVVGMRAAQETYGHWPKPLKGKWSDILDAMDEYDSGLNEDLTWPIAEITAAGSSPESQSSKHPGSRFSTPTPAPADESAYGPAEPAHFEALASSDVDHRSDFTIAEEPVEQTTLSDETAQEPVADAQVRSAIEKKTSGEMTIAFKNDQTIALAPAEYMATQHDAIPNNDKSDTDLDGKRNEAQQSLFPFARQRKGKKQKKNKNKKKAAKKGKNSRKPSAGPDPAPSHELSGPEEESKDKSEPEELTSVAFRLSRTSLNAIAETPLEPGVVFNRFFNSWRLPELLARGVTVPTVPAHRDDDGKIIYGYNWSHPRFAVIDRLERDVVMWDHSVTLGEPGEVSCFKRARDNRKDDGSPDGDKRKAGTSSSEKYNRCAHDGGSDRSDGSDCASRNERDLVKDRFGMSEEGLENWLEVWTHEFMPLAKRYSKKKWEDLDWRSEPLVKPKTPTQISTAPKGVVMIEKGVVDSDDLVKEQNKILTECFRSGNWKEVCGEGGSRAMLVTLPDGDKLEIPQCRLSTVDKVIGLEVNPKAKKLQVMTEKTLELPEVMLGYILPAPEPPSQPTTGSDKSERSAAPKPQQPTKSSINTKSLKNKPLTETDSQKEELEGPASPAQKKDSEDDLIKPKPSTPEWLVIPESDSSLEMPELVPASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0S969</accession>
    <name>G0S969_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">homocitrate synthase</fullName>
            <ecNumber evidence="5">2.3.3.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CTHT_0044760</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>acetyl-CoA + 2-oxoglutarate + H2O = (2R)-homocitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12929"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58884"/>
            <dbReference type="EC" id="2.3.3.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:12930"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.14" evidence="5"/>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694865.1">
        <property type="nucleotide sequence ID" value="XM_006694802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S969"/>
    <dbReference type="STRING" id="759272.G0S969"/>
    <dbReference type="GeneID" id="18258514"/>
    <dbReference type="KEGG" id="cthr:CTHT_0044760"/>
    <dbReference type="eggNOG" id="KOG2367">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022158_2_2_1"/>
    <dbReference type="OMA" id="NTMRMLV"/>
    <dbReference type="OrthoDB" id="2015253at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00028"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004410">
        <property type="term" value="F:homocitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07948">
        <property type="entry name" value="DRE_TIM_HCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.260:FF:000002">
        <property type="entry name" value="Homocitrate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000032">
        <property type="entry name" value="Homocitrate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02222">
        <property type="entry name" value="Homocitr_synth_fung_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050073">
        <property type="entry name" value="2-IPM_HCS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048253">
        <property type="entry name" value="DRE_TIM_HCS_fun_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011872">
        <property type="entry name" value="Homocitrate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054691">
        <property type="entry name" value="LeuA/HCS_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02146">
        <property type="entry name" value="LysS_fung_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277:SF48">
        <property type="entry name" value="HOMOCITRATE SYNTHASE, CYTOSOLIC ISOZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277">
        <property type="entry name" value="HOMOCITRATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22617">
        <property type="entry name" value="HCS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="15">
        <location>
            <begin position="39"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="410"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGS19980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="437" mass="47852" checksum="AFD4E22D743DA37F" modified="2011-10-19" version="1">MSGNGACNGTKNGVSNGSAYYRSNPYQPVPDFLSNVDKFKIIESTLREGEQFANAYFDTETKIKIAKALDEFGVDYIELTSPAASEQSRRDCEAICKLGLKAKILTHIRCDMRDAKLAVETGVDGLDVVIGTSSFLREHSHGKDMAYIEKTAIEVIEYIKSKGLEVRFSSEDSFRSDLVDLLSLYKAVDKVGVHRVGIADTVGCATPRQVYDLVRTLRGVVSCDIETHFHNDTGCAVANAYCALEAGATHIDTSVLGIGERNGITPLGGLMARMVVTAPEYVKSKYKLHKLKEIEDMVAEAVQINVPFNNPITGFCAFTHKAGIHAKAILNNPSTYEILDPADFGLTRYVHFASRLTGWNAVKTRVKQLGLSMTDDQVKECTAKIKALADIRPIAIDDADSIIRSFHISLQPQPHRPSEPVPTDEVIPAEEEPEPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9G6</accession>
    <name>G0S9G6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0045810</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphosulfolactate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694962.1">
        <property type="nucleotide sequence ID" value="XM_006694899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9G6"/>
    <dbReference type="STRING" id="759272.G0S9G6"/>
    <dbReference type="GeneID" id="18258619"/>
    <dbReference type="KEGG" id="cthr:CTHT_0045810"/>
    <dbReference type="eggNOG" id="ENOG502RBUH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062679_1_0_1"/>
    <dbReference type="OMA" id="KNQQVEF"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003830">
        <property type="entry name" value="ComA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036112">
        <property type="entry name" value="ComA_synth_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48413">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48413:SF1">
        <property type="entry name" value="PROTEIN HEAT-STRESS-ASSOCIATED 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02679">
        <property type="entry name" value="ComA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102110">
        <property type="entry name" value="(2r)-phospho-3-sulfolactate synthase ComA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS20077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="320" mass="35502" checksum="4B613D16F6D96DA4" modified="2011-10-19" version="1">MSLRGIESLLSGPFRALSTSPYPLANGSDSKPKYAQQQSPILLDDEKGFSFVRHNTRPPKPRKVGVTEIRGSYYSVMGKRYLKDVLETMSYNIDGLKFGGGSFSLYPEPQLRELIDLAHEHGVYVSTGGWIEHLLTHPSPHDIITRYLTKCRSLGFDVIEISSGFLSIPADDWLRLVDLVHSEGLIAKPEIGIQFGAGGDTDVASLESVEGGTSGPEKVVALGKKFIAQCGVERIMIESEGITENVRKWRTDVVRGILEGLPKENVMFEAAEPKVFNWYVREFGADVNLFVDHSQIVQLSALREGIWGMGDTWGRVVSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9I1</accession>
    <name>G0S9I1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0045970</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS20092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694977.1">
        <property type="nucleotide sequence ID" value="XM_006694914.1"/>
    </dbReference>
    <dbReference type="GeneID" id="18258635"/>
    <dbReference type="KEGG" id="cthr:CTHT_0045970"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003897_0_0_1"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF30">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
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    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
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    <sequence length="1486" mass="158589" checksum="0FB9793D212B187C" modified="2011-10-19" version="1">MTSLRKILHLNDDRSSLPLPSPSPHNKRDPAPATSGSETPNDAVKEYVDKPSSLPGSERKDINQASPAGHANTKRGSSPRPVESTTSISQPDPSGATDPRPSSAPKSDLSSSSSSSSRPSSTSASSSTPSQSAALSQSQSQSVSASSRQSTRDKTSNTMNNPVGFFQLSPFPPAGLQRPFHPHINHANIPIKLTPKTRRISKAQKGLPVHVCDLCNPPKTFTRAEHLRRHQLSHGKPQFQCPGCDRAFHRRDLLDRHKLRHEQEGQSAQTAESAQHGSPSSPTPTTTTTTTTTTTTTTTTTQTQQRSPCESISGLSPSPSTTAPPTPNPNVAAQAGFSQPVNISGPSQQRGVGSGPRSRRNSSQQAQNTYPVSSPSIPIMSPTPPTSLSPTLPGNMSQFPSASRPSPPAIYVVTQGISVQPAELPDLQSSASSAWPSSATDSTFSTPVSDIGRNARWHRGHPSPTVSEWSSSQRLSPYPPPTPRRIHSQSPAPSAMGDTLRSPIFAGSPFPGAQQPSEPCTFSNGMLSVPAPVGFVPSNSPGNPSSQQPSVVEIPYRPQHRHSDSVSTTRTQTSPMGTAQPGETALVTTPAVPAQLDPMAGLDRRKSVMVDTDQMGLGILSGLAISYGTSGNGLANPAVDQSSQVNVSVNVDMDINLNNGSCSGEYAVTMPLSSPSAMSQLSETVRKDIPRYVGEYWNLVDPMLPLVHRLSYEAAPEDALTCAMAAVATQYLDNKDDRQKGTQLHDVAQQEIKRIPQWTLQTMQAILLCEYFSRFRGRKAVSEPSNRFKSLYGRVSAARSSSSCLSPSSSIYGGNAIIDSNAWTPVSSPASPVPSVFEGGSLSMSTTPTMSPIALRHLSPLPGMPWDGLGSSRRSVSSGASSPLAPFPPTFELPIRRRRSSTFNYNLNVPASSLSSHFRSRSQSSLTSSWSSSSSSSSSSSSSFFFFFFFLLLPFLTACFTPATTPVLSSFSASFASLSPSQPFFPGQSCSRPAGQACDSFTPDDVMPILNQPCLSVQDRWQRWVDIESRRRIFAVCLFIDAHTAIYHEQQFRMYDCQPDRPGAFRNIPLFTRSSHLWASRTADEWAAEVAADPSLLMPETLPSLEQLTTESVDGCTPLDRLTILSVSALSLPRRRPVIPNTNSLSTASSPAPEMIDPSHPPSSSDPTAHLTLAQTLASLSHSVQSLDAEALLLRLFPHCPIVYTYLALHHTPLRDLLAVAGNSWVFAQKLLSESAFLEAQRRVTAWAAAVGHETGVVGAGEGKSAVKAVGYAARALLGFLGEDGRGMVGRGPMKRVPWVADLGDYWAVYCCALVCWAVGRAMGGHGHGGHQQQQYGELLAVHDPAQFHSLSPGSPTLSTGPSSSSIATPSASASAMDTDDDPALDESPLSEQEQSALLFLRTVASSFPSPHDGIDRSALSWPSAVAAAGIDMRDATLGVVALVRRRLKADCLCPSSRLFWDAVEKVLVRLEKGGGEGVGVHGLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9I4</accession>
    <name>G0S9I4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phospholipase D1</fullName>
            <ecNumber evidence="3">3.1.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Choline phosphatase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Phosphatidylcholine-hydrolyzing phospholipase D1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0046000</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phospholipase D family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="3"/>
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        <property type="protein sequence ID" value="EGS20095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006694917.1"/>
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    <dbReference type="KEGG" id="cthr:CTHT_0046000"/>
    <dbReference type="eggNOG" id="KOG1329">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000690_0_1_1"/>
    <dbReference type="OMA" id="ERISHST"/>
    <dbReference type="OrthoDB" id="14911at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="PH_PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="PLD-like_dom"/>
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    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
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        <property type="entry name" value="PLipase_D_fam"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
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    </feature>
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            <dbReference type="ARBA" id="ARBA00079280"/>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PROSITE" id="PS50035"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1921" mass="213753" checksum="507C6B04401BCDD3" modified="2011-10-19" version="1">MPDTRPQNAAVALRDTPLSLETDNGTPTRPQPLGSDQFDFATRPSSLRSQLGPENEGPTSTGERISHSTSGFRPQHLTVQVPQSPGPVSPRTTLSDILEPSSAGPSGKNVQFGQEEEIIPDPTPSHSHSRTGSWDTREALGKFRGSGLMAKLKELAGPISTPSQPPRTPVGGSEFPSTASSPTTSRHPTRHEGSDDDADAEETADETTAGHPNKGKQKKKRRMRRYRVNDHSSLPNTPGGPGAVETPTSANASGHNVANSSPHGPLSFLRRTTFAGFDDHGFSEGEGRDRLFRERLARRAAAHGLSISRMGIDADDADGPSSSRMGYHFRRFSALGGGGGGGGGGGGGDRGGGVSDGDAMSPRRPFFGTERASTFGAQKWRQVKGALKLLRQKREEQFDFSKSAELMAELRAVAPAVLILASMIQRDEHGNKRIPVLLEQLRLRITDSQPIQGKDSERHWIFTVELEYGSGPSQMKWTIKRTIKDFLNLHWKYKLALANEGFGSNLGNRPKQPSFPLSAFPYLRGVRGLEEDGDEEKDKPAGPSHTNTTDTMQSGLPQPPPSLHIAGEDTAGENTAGEITAPEGTDAENRPPRRRSRMPYLGGRRKPSALGSNADLSQAAADAAAQRRRYVERQQRMLEKYLHDMIRWLMFRADSNRLCRFLELSALGVRLAAEGSYHGKECYLHIQSSKGLDFRRVLTPGKVIARHTRKWFLVRQSYIVCVESPENMNIYDVYLVDSKFQIVSKKSKKQAAEQDDDDDDGDDNIENLDLSTRPQQKHQKHHTLKLITSERKVKLFSPNQHLIAQFEESIREMLKNTPWHGKNRFNSFAPVRTGVYAQWLVDGRDYMWNVSRAISMAKDVIYIHDWWLSPELYMRRPACISQKWRLDRLLQRKAAEGVKIFVIVYRNVEAAIPIDSEHTKFSLLNLHPNIFIQRSPHQFKKNQFFFAHHEKICIVDHDIAFIGGIDLCFGRWDTPQHPVADDKPTGFEPGCDLPKDAEHCQLFPGKDYSNPRERDFFKLTDPYEEMYDRSRTPRMPWHDVGMQVVGQPARDLTRHFVQRWNYVRRGRKPTRPTPFLLPPPDCRPEEMEAVGLTGTCEVQILRSASTWSLGITETEDSIHSAYIKMIEDSEHFVYMENQFFITSTETLNHKMVNGIGDALVRRIIRAHRNHEDWRAIILIPLMPGFQNEVDQQDGTSIRLILQCQYRSICRGEHSIFGRLRAAGIEPEDYIQFFSLRQWGKLGSGLLTTEQLYIHAKCIIVDDRVALIGSANINERSLLGNRDSEAAAIVRDTDMIWSTMAGRPYQVGRFAHTLRLRLMREHLGLDVDEILEQERQADLMEQDERFRREMDEIYHSDDPELGPVKDGPSLTREKRKTTVSYAEPEAQLPRSPTRSHPSAGQSGDADAEEPKRQRRKKRMSWSSWRSTAGRDDEGREEDLGAERYRLEVEGFGPDHWRQAQEQGLDQGRDSVIVGGEHEVLVHDVSAEGKGTVDHPVDVRRPKSSGGKSAAAIAKEEALGSSSLAAAAVVEQERPQTSRRGSQPSQFQAQTSEENNNNNGDYSSNRSPSPSPLSHFIASIRQADIDKDCMRDPLDPDFYENVWCRVAENNTRIFRRVFRCMPDSEVTNWSEYRNFADYYKKFKLSMEELITGGRTSSAGVMAASEEAEKEKEKSLDRQVAAGGAGIAAPGPAVVAGAVINEKVTGPVGKVAQAVMNEKEALKADAGPYENSSLNAANGNGNGAGNGNGNGNGNGNGWITSSHDTLPGSESSLALSSRPSQRPRRDSSYARGRDITARPSTTRGSTSSGAATPTPNAAPSMEQQLSQSQPKVTTLAPTPSQRRGGTAGGTRRRATTRGSRRGGGSSNTGTALEWQMLTPQQAEELLKLTQGPLVQFPYDWLVVEETNGNWLFQVDMVAPLAIYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0S9Y9</accession>
    <name>G0S9Y9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ornithine decarboxylase antizyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0040370</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with ODC and thereby sterically blocks ODC homodimerization.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ODC antizyme family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694446.1">
        <property type="nucleotide sequence ID" value="XM_006694383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0S9Y9"/>
    <dbReference type="STRING" id="759272.G0S9Y9"/>
    <dbReference type="GeneID" id="18258075"/>
    <dbReference type="KEGG" id="cthr:CTHT_0040370"/>
    <dbReference type="eggNOG" id="ENOG502S3W3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086393_0_1_1"/>
    <dbReference type="OMA" id="RLFCETM"/>
    <dbReference type="OrthoDB" id="5959761at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008073">
        <property type="term" value="F:ornithine decarboxylase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075523">
        <property type="term" value="P:viral translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002993">
        <property type="entry name" value="ODC_AZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038581">
        <property type="entry name" value="ODC_AZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10279">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE ANTIZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10279:SF10">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE ANTIZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02100">
        <property type="entry name" value="ODC_AZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0688">Ribosomal frameshifting</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="58"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS19561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="298" mass="32361" checksum="665345B0A6B9CF07" modified="2011-10-19" version="1">MAPMKQTEYNHHSSNYGEDIDRQEPSGIPEVPSTGLPSPPSSPPLAALTATNELALAPKTSAKRNSNGSLGGNSNVTNGRGSGAVGGTSIDLDAWHRRRGGAALRIREECERFFCETLRAVFLGERNSAPQISSLTGAHNNGNHANRNRVVINNSSERLTARVNGSGVTNGSSVTNNRNDRSHVSCWLEIWDYSGGSSFRGFVGEDPQSSARTLFIFLDSQRPRRDFKQALVALIELGEGPLACSYGVICVERSTPDEERDSLINGLQWAGFSLSTLDLWSNGPDKISKRWLFLTTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0SA16</accession>
    <name>G0SA16_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hsk1-interacting molecule 1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0040660</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694473.1">
        <property type="nucleotide sequence ID" value="XM_006694410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SA16"/>
    <dbReference type="STRING" id="759272.G0SA16"/>
    <dbReference type="GeneID" id="18258104"/>
    <dbReference type="KEGG" id="cthr:CTHT_0040660"/>
    <dbReference type="eggNOG" id="KOG4139">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017715_0_0_1"/>
    <dbReference type="OMA" id="GMKIWAI"/>
    <dbReference type="OrthoDB" id="21380at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031431">
        <property type="term" value="C:Dbf4-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010571">
        <property type="term" value="P:positive regulation of nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901987">
        <property type="term" value="P:regulation of cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3410:FF:000001">
        <property type="entry name" value="Protein DBF4 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3410">
        <property type="entry name" value="DBF zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055116">
        <property type="entry name" value="DBF4_BRCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013939">
        <property type="entry name" value="Regulatory_Dfp1/Him1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051590">
        <property type="entry name" value="Replication_Regulatory_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006572">
        <property type="entry name" value="Znf_DBF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038545">
        <property type="entry name" value="Znf_DBF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375">
        <property type="entry name" value="ACTIVATOR OF S-PHASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375:SF26">
        <property type="entry name" value="PROTEIN CHIFFON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22437">
        <property type="entry name" value="DBF4_BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08630">
        <property type="entry name" value="Dfp1_Him1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07535">
        <property type="entry name" value="zf-DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00586">
        <property type="entry name" value="ZnF_DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51265">
        <property type="entry name" value="ZF_DBF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DBF4-type" evidence="6">
        <location>
            <begin position="714"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="48"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="486"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="535"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="669"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="181"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="556"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="673"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS19588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="767" mass="84088" checksum="5E44BAF656A5FFD8" modified="2011-10-19" version="1">MLPLSEWSTTNGAPACSAAAKLRSSSNIRLSTARFKCTTTIIITTTTTTTTSTGPSLAAANRKPATRNPRRGSSPPVSARSWRQPTIDDCCESTNPNAANSPLRPSAAALPGAKKCRSHADMLREEAYPQPPPAKRQMIDRGVASPSRSKTTMAAATSTTTSLSTAATTTASRADIHRSASRVTASTHGSQRASHASTHADYQPTQQDIEMLRQWHANTRAAFPKMVFYFESIPDDLRARLAKQVSSLGAREEKFFSIEITHVVTTRPIPPVKKTHEVTETAEEAAPANNEQPETINPSLLNRNTTTEPLSLAAARRASKLAYDAASKKLPIRVHEDPIKRPKPRSTDVLDRAREMGKKIWSLEKLQKILEYLLYPDPITSAALGLSRHNTRASTKPTDPQDKLAQALEAERVHGPSDRDPTVSNRELKLFKGPYIYVYDIDEKTKPIMAREYPKVSDPKDGEWPQFRVTSHGRCPFIIDEHYDIPEKKRRDKDRAKERPAKEEVETTAVATATTTTTTTTTAAAAAAAAAAAVPTAQAPKPVEENPPKPVTGKRTLKEMEDGHNRGAAVTRSTEQFDREKAQNPPSFDFRTNAFMSRAKPGLFLAGEPVASGLQPSNVTSAIRSQMVSSTGGVLGAKAGTSKEIHGLQRRVVLQKAVTPAVAQDVGHDATTFGRSASTSRAQPKPELLDGEEPQKRDKLRRSASMPVSQPKKRDPKPGYCENCQDKFADFEEHIVSRQHRKFAENDANWVQLDALLAQLKRVPRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>G0SA43</accession>
    <name>G0SA43_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0040940</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694500.1">
        <property type="nucleotide sequence ID" value="XM_006694437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SA43"/>
    <dbReference type="STRING" id="759272.G0SA43"/>
    <dbReference type="GeneID" id="18258132"/>
    <dbReference type="KEGG" id="cthr:CTHT_0040940"/>
    <dbReference type="eggNOG" id="ENOG502RH53">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1239997_0_0_1"/>
    <dbReference type="OrthoDB" id="5230713at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS19615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="223" mass="26060" checksum="885EC3164E268892" modified="2011-10-19" version="1">MVASISSLRRPDSPVSAPIIGPKEVDMFEIPNMLPNYDQAIDYWEAQEFLRELTRRDWPDREDMIRFECSMTLEELRNVGRMSKEEGTRTCQDFVRAPVIWEKVAESLWERLREEAEAHPEDKDQKADDQLLDGSSKRRRCWRMVWKVRRSKEDDKPAAEKDITTGCPFCPNRCTMYVPRYPASIHGDKPSSLKDWALARIKCISERVLPYKVTMASRSSQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAE6</accession>
    <name>G0SAE6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucanase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CTHT_0042000</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyl hydrolase family 6.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694603.1">
        <property type="nucleotide sequence ID" value="XM_006694540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAE6"/>
    <dbReference type="SMR" id="G0SAE6"/>
    <dbReference type="STRING" id="759272.G0SAE6"/>
    <dbReference type="GeneID" id="18258238"/>
    <dbReference type="KEGG" id="cthr:CTHT_0042000"/>
    <dbReference type="eggNOG" id="ENOG502SATK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015488_0_0_1"/>
    <dbReference type="OMA" id="FCANATP"/>
    <dbReference type="OrthoDB" id="64893at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.40">
        <property type="entry name" value="1, 4-beta cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016288">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036434">
        <property type="entry name" value="Beta_cellobiohydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001524">
        <property type="entry name" value="Glyco_hydro_6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876:SF10">
        <property type="entry name" value="GLUCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01341">
        <property type="entry name" value="Glyco_hydro_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001100">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00733">
        <property type="entry name" value="GLHYDRLASE6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51989">
        <property type="entry name" value="Glycosyl hydrolases family 6, cellulases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00656">
        <property type="entry name" value="GLYCOSYL_HYDROL_F6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="4 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005130816" description="Glucanase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6 8">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001100-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001100-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGS19718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="384" mass="42033" checksum="1FAA86B77466F2BB" modified="2011-10-19" version="1">MRPSTLLLTALSTGSLVAAAPSFTPKPSTTKSTNPFEGKTQFVNPKWAAKLDQTFWNLLKKGDILNALKVPKIQATMSTFVWVSRRSELVNIDDAIAAARKAQKLTGKKQIVGLVLYNLPDRDCSAGESAGELSSAQNGLEIYKEEFVKPFAEKVAAAKDLTFAVVLEPDSLANLVTNMGIEFCANAADVYREGIAHAINALQYDHVHLYIDAAHGGWLGWDPNLPLAAKEFAKVVKLAGEKGGNKIRGFVTNVSNYNPFHAKVRENYTEWSNSWDESHYVSSLAPFLEEEGLPSRFIVDQGRVHLPGARKEWGEWCNVEPAGFGMAPTTKTNNTHVDAIVWVKPGGESDGQCGMAGAPRAGEWFDEYAQMLVKNADPSVFKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAG2</accession>
    <name>G0SAG2_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mandelate racemase/muconate lactonizing enzyme-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0042160</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694619.1">
        <property type="nucleotide sequence ID" value="XM_006694556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAG2"/>
    <dbReference type="STRING" id="759272.G0SAG2"/>
    <dbReference type="GeneID" id="18258254"/>
    <dbReference type="KEGG" id="cthr:CTHT_0042160"/>
    <dbReference type="eggNOG" id="ENOG502QU7C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030273_2_0_1"/>
    <dbReference type="OMA" id="SGAIDVC"/>
    <dbReference type="OrthoDB" id="14161at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050023">
        <property type="term" value="F:L-fuconate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03324">
        <property type="entry name" value="rTSbeta_L-fuconate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000007">
        <property type="entry name" value="Mitochondrial enolase superfamily member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034610">
        <property type="entry name" value="L-fuconate_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046945">
        <property type="entry name" value="RHMD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794">
        <property type="entry name" value="ENOLASE SUPERFAMILY, MANDELATE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794:SF58">
        <property type="entry name" value="MITOCHONDRIAL ENOLASE SUPERFAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00111">
        <property type="entry name" value="L-fuconate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00270">
        <property type="entry name" value="L-galactonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00179">
        <property type="entry name" value="mandelate_racemase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00909">
        <property type="entry name" value="MR_MLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="5">
        <location>
            <begin position="200"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS19734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="443" mass="49228" checksum="72B7597176259990" modified="2011-10-19" version="1">MVEITITGWTTRDIRFPTSLDKTGSDAMNVAGDYSAAYCILQTDLTYTGHGMTFTIGRGNDLVCAAINHLAARIQGRTLSSLVSHWGQTWRHLVNDSQLRWIGPEKGVIHLALGAVVNALWDLWAKVLGKPVWRVVADMTPEQVVDCIDFRYITDALSPEEALELLRKAEPGKQERIRDAENNRAVQAYTTSAGWLGYGEEKVRALLQETLAAGYKYFKVKVGGGVEQDRRRLAIAREVIGYDKGNVLMVDANQVWSVPEAIEYMKQLVEFKPWFIEEPTSPDDIMGHKAVRDALKPYGIGVATGEMCQNRVIFKQLLMASAIDVCQIDACRLGGVNEVLAVLLMAKKFGIPVVPHSGGVGLPEYTQHLSTIDYVVVSGKQSLLEYVDHLHEHFVYPAIIKDGFYQTPTEPGYSVEMKPESMERYEYPGGRVAGGGPRRPRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAH5</accession>
    <name>G0SAH5_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Autophagy-related protein 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0042310</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the ATG13 family. Fungi subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694632.1">
        <property type="nucleotide sequence ID" value="XM_006694569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAH5"/>
    <dbReference type="STRING" id="759272.G0SAH5"/>
    <dbReference type="GeneID" id="18258269"/>
    <dbReference type="KEGG" id="cthr:CTHT_0042310"/>
    <dbReference type="eggNOG" id="KOG4573">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007151_1_0_1"/>
    <dbReference type="OMA" id="FHQVGPT"/>
    <dbReference type="OrthoDB" id="70161at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040182">
        <property type="entry name" value="ATG13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018731">
        <property type="entry name" value="Atg13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13430:SF4">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10033">
        <property type="entry name" value="ATG13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy-related protein 13 N-terminal" evidence="6">
        <location>
            <begin position="69"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="348"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="639"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="785"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="823"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="397"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="477"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="543"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="639"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="661"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="741"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="832"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="892"/>
            <end position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS19747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="952" mass="102790" checksum="41F606AD62370E15" modified="2011-10-19" version="1">MHQQPRHPPRVASPASSPQTNPARTNNPRDRPRSSLDITTRRDGLDTNGSETPAPGPSRESIKKLDQIIQNFYYKAAVLILQSRLNLTPAVARNSDGRKLNKWFSIDTDDIEEFKEELRVYRTCSAFDNPPPPMIVETYIDASSISSSQSLVLIDENGKRWDVLEALNSSETPDDSPRRRRGQRRSAEVVLERWRVELRCLPNIDRDEFGPSLPAIYKRAIVYFRALFMMTRMMPCWKYSQQALAKGIHPALEVKCRILTTEPEYTSYDPLRIPLHDGGEPVTEYFFPDLEVPIGRFYSSVTYRNDVNFRVDDAESLLSSRFMGADDALFKPSIASRRDHAVALDSFAEPGSLPSRNQGRGVPEPQQTYGSLSTFHGPGAYGASPITALRSVRPPGSDTSSPTASTSTSMEQPEPPHSLPIRGATARPSLRTYEPSRRPSVSFQPFKAGSLSGSPRISEGEVPPSPQSYTRPGLSGPSRTGARSSLTAGSAASLRGPPVAPPQDVPSVTGSPRPPSRYSSSFGHRRGRPSFGGQSLKGDDDQASSGKQSLSSSAQPGSGFLAELGGVGSSGSFAADDDNISEFLKALESRKTLKSFEPSRAGEATASKRTAAQLSKFILLRDSHAALTDSMASSMYLQRPSTTSSSRQITPVPAMNPSTLSVSSSPGKPVSPHTPHMPAIPSRLSENSIIDYEAEARQTTRHRGTPNIATTEEEEPPSEETSNSETPFATQRDDRSVASPAGTGTATTAAIDIPMSPRLLQVSAAGNRRASSVAHQQHRSLLADLDDFSGARHQRSASVEDASLGRREVPSLSALLAFQRGGERIGADSRPAGEAGEDAQQQAGNSQVRSEGAEGSESRDIKSKQRSGVSGRFAGGSSVEGDEEPLLFAMSELERESRRSLEEGRQPSPSNEGQAGSGRDLLTTGGAAPRSGTPAGGREKPYEPRGILRKGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAJ0</accession>
    <name>G0SAJ0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fructose-1,6-bisphosphatase</fullName>
            <ecNumber evidence="5">3.1.3.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">D-fructose-1,6-bisphosphate 1-phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CTHT_0042460</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the FBPase class 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="5"/>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694647.1">
        <property type="nucleotide sequence ID" value="XM_006694584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAJ0"/>
    <dbReference type="STRING" id="759272.G0SAJ0"/>
    <dbReference type="GeneID" id="18258284"/>
    <dbReference type="KEGG" id="cthr:CTHT_0042460"/>
    <dbReference type="eggNOG" id="KOG1458">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039977_1_0_1"/>
    <dbReference type="OMA" id="YIPENCP"/>
    <dbReference type="OrthoDB" id="10256725at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005986">
        <property type="term" value="P:sucrose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00354">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000009">
        <property type="entry name" value="Fructose-1,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000001">
        <property type="entry name" value="Fructose-1,6-bisphosphatase class 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01855">
        <property type="entry name" value="FBPase_class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044015">
        <property type="entry name" value="FBPase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000146">
        <property type="entry name" value="FBPase_class-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033391">
        <property type="entry name" value="FBPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028343">
        <property type="entry name" value="FBPtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020548">
        <property type="entry name" value="Fructose_bisphosphatase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006778">
        <property type="entry name" value="PRK09293.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556">
        <property type="entry name" value="FRUCTOSE-1,6-BISPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556:SF1">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00316">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18913">
        <property type="entry name" value="FBPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500210">
        <property type="entry name" value="FBPtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000904">
        <property type="entry name" value="FBPtase_SBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00115">
        <property type="entry name" value="F16BPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00124">
        <property type="entry name" value="FBPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class I N-terminal" evidence="14">
        <location>
            <begin position="20"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class 1 C-terminal" evidence="15">
        <location>
            <begin position="213"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGS19762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="354" mass="39015" checksum="D6B95B6AAD6D19B5" modified="2011-10-19" version="1">MVAANGNGNSFTEQVDTNIITLTRFLTEEQVKHKEATGDFTLLCHALQFAFKSIAYYIRRATLVNLTGLAGSANTTGDEQKKLDVISNELFIEAMRSSGRVALLVSEEEENVIFFKQGPHARYAVACDPIDGSSNLDAGVSVGTIFGIHKLAEGSRGVKEDILKPGTELVAAGFTMYGASAQLVITMKGGSVNGFTLDNGLGEFILTHPNMRIPRKRAIYSVNEGNSLYWEDHVKAYFESLKQAQPDNGKPYSARYIGSMVADAYRTLLYGGIFAYPADKKSPKGKLRILYECAPMAMVFENAGGQAVDSNMRRMLEVVPQDIHDKSGIFLGSYDEVEKVKEFYKKKDELKQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAQ1</accession>
    <name>G0SAQ1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative FMN binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CTHT_0043080</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988043">
        <property type="protein sequence ID" value="EGS19823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006694708.1">
        <property type="nucleotide sequence ID" value="XM_006694645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAQ1"/>
    <dbReference type="STRING" id="759272.G0SAQ1"/>
    <dbReference type="GeneID" id="18258346"/>
    <dbReference type="KEGG" id="cthr:CTHT_0043080"/>
    <dbReference type="eggNOG" id="ENOG502S42E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067890_0_0_1"/>
    <dbReference type="OMA" id="EMTSTQI"/>
    <dbReference type="OrthoDB" id="444432at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34071">
        <property type="entry name" value="5-NITROIMIDAZOLE ANTIBIOTICS RESISTANCE PROTEIN, NIMA-FAMILY-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34071:SF2">
        <property type="entry name" value="FLAVIN-NUCLEOTIDE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGS19823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="264" mass="29184" checksum="FD70DAA78C3FAC4D" modified="2011-10-19" version="1">MPLRNLQYPKHPYNTVKRYKDRADYSLSTIHSIFNTSPLLHISFVDPNSDVPFPSSLPMIGRLGSFTNPSADLGEVLDLYLHAYVSSRLVNLVREASNSPESKGFPVTVSTAHVDGIVLALTPNAHSYNYRSATVFGYATLVTDVEEKLYAMQLITDGVVPGRWENTRVPPNKGEMASTAVVRVKIVSGSGKVRSGGCHDDRGDLESEEVTGRVWAGVVPVWTMYGEPVPAGYNRVAEVPAYLEEWRKEGNRGREELAKEAMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0SAY0</accession>
    <name>G0SAY0_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-B22</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase B22 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CTHT_0048190</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="20 21 22" key="2">
        <citation type="journal article" date="2022" name="Sci. Adv." volume="8" first="eadc9952" last="eadc9952">
            <title>Conformational changes in mitochondrial complex I of the thermophilic eukaryote &lt;i&gt;Chaetomium thermophilum&lt;/i&gt;.</title>
            <authorList>
                <person name="Laube E."/>
                <person name="Meier-Credo J."/>
                <person name="Langer J.D."/>
                <person name="Kuhlbrandt W."/>
            </authorList>
            <dbReference type="PubMed" id="36427319"/>
            <dbReference type="DOI" id="10.1126/sciadv.adc9952"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.44 ANGSTROMS)</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Mammalian complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695182.1">
        <property type="nucleotide sequence ID" value="XM_006695119.1"/>
    </dbReference>
    <dbReference type="PDB" id="7ZM7">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.77 A"/>
        <property type="chains" value="R=1-99"/>
    </dbReference>
    <dbReference type="PDB" id="7ZM8">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.76 A"/>
        <property type="chains" value="R=1-99"/>
    </dbReference>
    <dbReference type="PDB" id="7ZMB">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.75 A"/>
        <property type="chains" value="R=1-99"/>
    </dbReference>
    <dbReference type="PDB" id="7ZME">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.83 A"/>
        <property type="chains" value="R=1-99"/>
    </dbReference>
    <dbReference type="PDB" id="7ZMG">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.44 A"/>
        <property type="chains" value="R=1-99"/>
    </dbReference>
    <dbReference type="PDB" id="7ZMH">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.47 A"/>
        <property type="chains" value="R=1-99"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SAY0"/>
    <dbReference type="EMDB" id="EMD-14791"/>
    <dbReference type="EMDB" id="EMD-14792"/>
    <dbReference type="EMDB" id="EMD-14794"/>
    <dbReference type="EMDB" id="EMD-14796"/>
    <dbReference type="EMDB" id="EMD-14797"/>
    <dbReference type="EMDB" id="EMD-14798"/>
    <dbReference type="SMR" id="G0SAY0"/>
    <dbReference type="STRING" id="759272.G0SAY0"/>
    <dbReference type="GeneID" id="18258857"/>
    <dbReference type="KEGG" id="cthr:CTHT_0048190"/>
    <dbReference type="eggNOG" id="KOG3466">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108081_1_2_1"/>
    <dbReference type="OMA" id="KWERNAP"/>
    <dbReference type="OrthoDB" id="13598at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20263">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045292">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033034">
        <property type="entry name" value="NDUFB9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B22 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="20 21 22" id="KW-0002">3D-structure</keyword>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="17">
        <location>
            <begin position="5"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="66"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGS19360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PDB" id="7ZM7"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="21">
        <source>
            <dbReference type="PDB" id="7ZM8"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="22">
        <source>
            <dbReference type="PDB" id="7ZMB"/>
        </source>
    </evidence>
    <sequence length="99" mass="11617" checksum="5397BC1D04C35DD5" modified="2011-10-19" version="1">MSNRQAALSLYRRALKLALDWTVHRNLWRGQALYIRSLFEKNRNVTDPRLQRALLKETEKLLEKWKHPDPYCPPTAPGGSKYERNLPVPNLEPPPPLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0SBA6</accession>
    <name>G0SBA6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0049530</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988044">
        <property type="protein sequence ID" value="EGS19486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695308.1">
        <property type="nucleotide sequence ID" value="XM_006695245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SBA6"/>
    <dbReference type="STRING" id="759272.G0SBA6"/>
    <dbReference type="GeneID" id="18258991"/>
    <dbReference type="KEGG" id="cthr:CTHT_0049530"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="OMA" id="HGRYILA"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000085">
        <property type="entry name" value="Dihydroflavonol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="15"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS19486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="377" mass="41978" checksum="8FDADE8CBBCB40F8" modified="2011-10-19" version="1">MAQTSFSSTPSPKTALVTGASGYIGLHIVNTLLEEGWTVHGTVRSLRDERKVQPLRDVAEKYHAQDRMRLFEADLLTPDSFLEAMKSCDVVFHVASPFFAPEKVRDPQKQLVEPALEGTRNVLNCVEKTECVRRVVLTSSGWYTQASSRNMSRSLLTSDRVAATFGDNADVLQYPNQTLTEDNWNTTSTLQHNPYQYSKTLAEKEAWKLASAQCRWDLVVICPGLVLGPSLTPASSSGSLDLLDQVLRGLMVVGAPDLSFAIVDVRDVALAHVRAATVPEAHGRYIVADGKLTSVLEVARCLKKVAKWPQLLPSWVLPHFVFRMVAPLMGLSMRWADLNQGVVFRVDNERATRELGINYRPVETTLEEHYRAWAGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0SC42</accession>
    <name>G0SC42_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0055850</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695913.1">
        <property type="nucleotide sequence ID" value="XM_006695850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SC42"/>
    <dbReference type="STRING" id="759272.G0SC42"/>
    <dbReference type="GeneID" id="18259623"/>
    <dbReference type="KEGG" id="cthr:CTHT_0055850"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016304_6_2_1"/>
    <dbReference type="OMA" id="VRIFKMQ"/>
    <dbReference type="OrthoDB" id="446113at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12611">
        <property type="entry name" value="RRM1_NGR1_NAM8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12613">
        <property type="entry name" value="RRM2_NGR1_NAM8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12346">
        <property type="entry name" value="RRM3_NGR1_NAM8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000065">
        <property type="entry name" value="mRNA binding post-transcriptional regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000222">
        <property type="entry name" value="mRNA binding post-transcriptional regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000227">
        <property type="entry name" value="mRNA binding post-transcriptional regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF10">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="41"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="134"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="269"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="338"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="367"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS18968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="393" mass="42640" checksum="2B799E05B4AC4AF4" modified="2011-10-19" version="1">MADYSSTAAPGTGTNGPNMNGTNEANFSAPAPIAPNPDAPKTLWMGEMEGWMDETFIKNVFQTVMGESVQVKVIRDRNSGNAGYCFVEFQTPEAAQKALGLNGTPVPNSNRVFKLNWASGGGLVDRRDDRGPEYSIFVGDLGPEVNEFVLVSLFQSRFPSCKSAKIMTDAMTGQSRGYGFVRFSDEADMQRALVEMQGVYCGNRPMRISTATPKQRSHHHQYGHHPPAPMMPPVPGHPAAPPMWGNYPYYGQQYNPIQPMNQFTDPNNTTVFVGGLSGYVTEDELRSFFQGFGEITYVKIPPGKGCGFVQFVHRHAAEMAINQMQGYPIGNSRVRLSWGRSQNNSGVGTPYRPAPPPPHYMGGMPPHGAPPAPGYGPPFGGNPPQGPPPGPMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0SCP1</accession>
    <name>G0SCP1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ubiquitin protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0057920</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696112.1">
        <property type="nucleotide sequence ID" value="XM_006696049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SCP1"/>
    <dbReference type="STRING" id="759272.G0SCP1"/>
    <dbReference type="GeneID" id="18259830"/>
    <dbReference type="KEGG" id="cthr:CTHT_0057920"/>
    <dbReference type="eggNOG" id="KOG0417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_13_0_1"/>
    <dbReference type="OMA" id="WRAVMKG"/>
    <dbReference type="OrthoDB" id="9973183at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23812">
        <property type="entry name" value="UBCc_ScPEX4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="10"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS19167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="167" mass="18630" checksum="22F9DACCADA29060" modified="2011-10-19" version="1">MASAAATSRGAMRRLMKELDTWTNVESLTEEGIERLGPVNDDELLEWEAVINGKGVGYGYDNGRWLLRITIPPTYPLHPPTIKFVTPIVHANVNLQTGEICLDLLKDAWTPAYSILECVRAIRMLLSTPGIDSPLNVDVAALLRDGDTIAARRLVELWVDEERYEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G0SD00</accession>
    <name>G0SD00_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rhodopsin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0058970</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS19271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696216.1">
        <property type="nucleotide sequence ID" value="XM_006696153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SD00"/>
    <dbReference type="STRING" id="759272.G0SD00"/>
    <dbReference type="GeneID" id="18259935"/>
    <dbReference type="KEGG" id="cthr:CTHT_0058970"/>
    <dbReference type="eggNOG" id="ENOG502S3KC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115926_0_1_1"/>
    <dbReference type="OMA" id="QNCGNFS"/>
    <dbReference type="OrthoDB" id="5545479at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28139">
        <property type="entry name" value="UPF0768 PROTEIN YBL029C-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28139:SF1">
        <property type="entry name" value="UPF0768 PROTEIN YBL029C-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS19271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="13538" checksum="B94ADC1BE3602551" modified="2011-10-19" version="1">MCIVFTCGEHTFRKQVEGYEGLVCRCYNCGNYAASVVRSHPWFTFCFIPVLPLSIKGYEDVSCRICGFEQPLSHRPDVQAMRGGAAASGAVPGQAMPMHPPPMGPPQGWGYGGPPPKPDQMRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0SD32</accession>
    <name>G0SD32_CHATD</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">CTHT_0050640</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695407.1">
        <property type="nucleotide sequence ID" value="XM_006695344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SD32"/>
    <dbReference type="STRING" id="759272.G0SD32"/>
    <dbReference type="GeneID" id="18259102"/>
    <dbReference type="KEGG" id="cthr:CTHT_0050640"/>
    <dbReference type="eggNOG" id="ENOG502RG16">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015714_2_0_1"/>
    <dbReference type="OMA" id="YSPRFKY"/>
    <dbReference type="OrthoDB" id="2441642at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013927">
        <property type="entry name" value="TF_Opi1_Ccg-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR OPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38406:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR OPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08618">
        <property type="entry name" value="Opi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="628"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="645" mass="69655" checksum="7F9D2858622DA807" modified="2011-10-19" version="1">MEHCHMLSGQCLPPPLPQPQSQSQPQPQPHGSSEGATALAGGIPSHHRATGSVASAPEASVSTMQLDPMQPPPAPPPAPPAPPAPPAAPVQLPPLALSFPDEPPTELAPIQLPHEKSASVLGQQTLPPLSEVTGTQPQRHAPLSHPPASSHNPQQTRVNHWPSMNPFTTYYRPSYLESAESSPSMDSERSTGPRAASVSLDDPDVRIAAEALGQMRTDFMSSPKQSPSLISAAPGDRKTSVDCKPAPSSSQNSKQPEPEPLLSLITTTYPLLASTIGGAASAYRTGKNYSPHLKSGAEYVESCLNPVAKAVGTVSRKTGVEGGVRWIFGIRNKKQQALSDIESGDRGSTKRRKSERNDKESNLSNSTSPQLAADGFDDRRMSISTIDTLPPYDDQKSPAYTEVADEMTSRSCPPGTSPQPWPQRFVVTTSGLGVAMKQESLKSLRFCLKVLRETNSYVGEIIVKLKNVIDEYDRATQKDGEDQVMKDSSCSGAADLNKLLLRMKELKEDIFRVIQRTVQTVSKYAGSALPENARNIVHRQLMSLPGLYQFHYIRETSEGRRGNGSPEALVRDSAHLALLFAKEALQMMTQVGDVLNRTLVSAEEWCETLYRKKNDEQAQSSLNGIIHASTSSTAPSTDSDVKMSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G0SD97</accession>
    <name>G0SD97_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GCS light chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Gamma-ECS regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Gamma-glutamylcysteine synthetase regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glutamate--cysteine ligase modifier subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CTHT_0051000</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer of a catalytic heavy chain and a regulatory light chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695443.1">
        <property type="nucleotide sequence ID" value="XM_006695380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SD97"/>
    <dbReference type="STRING" id="759272.G0SD97"/>
    <dbReference type="GeneID" id="18259138"/>
    <dbReference type="KEGG" id="cthr:CTHT_0051000"/>
    <dbReference type="eggNOG" id="KOG3023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055657_0_0_1"/>
    <dbReference type="OMA" id="CTDILPR"/>
    <dbReference type="OrthoDB" id="5596051at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035226">
        <property type="term" value="F:glutamate-cysteine ligase catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032963">
        <property type="entry name" value="Gclm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13295">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13295:SF4">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="11">
        <location>
            <begin position="154"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="78"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGS18498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="335" mass="36699" checksum="4A5548F3BA1D62BC" modified="2011-10-19" version="1">MAKTTKLILSTGYTSLSVAHLQSPAQQLTSPRNIVSDGPSIVRRSCSPRAKNNPELISSLRSSFHSAQQEYAASLLRDTPSATPNGSSSSLPAAITSSNRPPTSAWTSEQDNVLYIPRIDPPTGLSEPPQHYNLTAKIFFLPNTPVQSRMSYAREALSLVLQELFPAQSVDLLVVSFPGLSFTADCEWEADRLNALQGNDAEELATWPAVEELHRSGLARELGVAEFGSEKLARFLEKVTVRPKVNQVNLRNCCNVPPPLAKLAKEQGIELLVHGDATEVVTRETLEEVLGDAGVIGEKEEVWPLWVVKYTAVVRDRGVIENKGYFVGAELVRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDB4</accession>
    <name>G0SDB4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative phosphoinositide binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0051170</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695460.1">
        <property type="nucleotide sequence ID" value="XM_006695397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDB4"/>
    <dbReference type="STRING" id="759272.G0SDB4"/>
    <dbReference type="GeneID" id="18259155"/>
    <dbReference type="KEGG" id="cthr:CTHT_0051170"/>
    <dbReference type="eggNOG" id="ENOG502RM76">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007315_0_0_1"/>
    <dbReference type="OMA" id="INGWIIH"/>
    <dbReference type="OrthoDB" id="41200at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000065">
        <property type="entry name" value="PX domain protein (AFU_orthologue AFUA_2G07450)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013937">
        <property type="entry name" value="Sorting_nexin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF47">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 122 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08628">
        <property type="entry name" value="Nexin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PXA" evidence="3">
        <location>
            <begin position="191"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="459"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="546"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="772"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="459"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="475"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="497"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="554"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="772"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="823"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="836"/>
            <end position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS18515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1087" mass="118296" checksum="C922620D3875CC7D" modified="2011-10-19" version="1">MRQQDASSPGMQPDTMEEPKEMNSPAVESPDAPAPRANPDCAAVGAANGSNSPSNSSGAKVVNADTKPPVLNEGAQSSDQQSLTTKIIDFLASASPGTLGGVAVGLAATTYFVLGRLGLVLIGAFGGIVSFIHWEQRNVEVARAVRGEKGLDLLERLLAAKKSEQDALRGETGSEEQQQDGALIRSFDDLQPETREALTELVDAVIDNYVKWWYSPIVPADKFFPLACRKTLTSFVASVANCLRRKRPADMFLDFVTNSSSLVVVFLSELSNAFAELPPESGLTAADAVYNYLASHPDSSLATLLNQKQQAHKFRMAAEDLVGFLDRSTYECDAVRIFLREILAGVILETALQKCSKADWINTWIVYFLESGEPDFSQAIDQGMQTGPGSDIVFADFDGNVGNIGLTKGNRNSFEQERARRKESLAAHKKKLSKADEEMELAMEGVNKLNGMVAQKGNASTESLPLPNGQQIVGYEKKDGSEKGDQTKSSARPLRMSGTSIKTTASEGLGIKNSEVSAPSTYQSEGLTPSSQDSFAVKNTGSQFTSFDQILPPARDEPEIEEDKKEPQKPPLTLHNAIITVLDEPGDGRIRSRPTWDYLVQIEPATIHYPGWMIVRKYSDFEAVHEVLRRIAAVSGATEFTEQHSALPSWKQYTRTALRGELERYLRDACKHRSLAESEGLKRFLERDHGHIPSAPKSGFEAVERLGKNVLGVLASAPLEGSKAVVGGVTSVLGNIGLVPKKQQPQPQPSQQSVLQDVTAASRLSISSLPRADSSLSLSGRGRARDSMDSQRSSIVNLQPGRIPPMERRASSQHSQGEGDATDAPRRARSSREYSRGSSRAPSRAPSRGPGTRSSPSPIFEGFQLPPPPDMIPDDYEIPVSPSRPPFNGDQLTLHHQRSLTMPTLTSHQRLHGPPLRGVKQHAKLTEQETRVAVELLFAVINELYTLSSAWNIRRTLLAAAKSFLLRPGNPSLLSIQNLIQESVLDANTSDSGIAAHLRKLRQNALPTEEEKAAWPAEMTEEEREKLRAKARKLLIESGVPAALMGVMGQAATSEALGRLFDCLQIEEIARGLMFGVIMQAVRTVTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDR8</accession>
    <name>G0SDR8_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Crossover junction endonuclease MUS81</fullName>
            <ecNumber evidence="14">3.1.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CTHT_0052750</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with EME1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the XPF family.</text>
    </comment>
    <dbReference type="EC" id="3.1.22.-" evidence="14"/>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695614.1">
        <property type="nucleotide sequence ID" value="XM_006695551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDR8"/>
    <dbReference type="STRING" id="759272.G0SDR8"/>
    <dbReference type="GeneID" id="18259313"/>
    <dbReference type="KEGG" id="cthr:CTHT_0052750"/>
    <dbReference type="eggNOG" id="KOG2379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014329_1_0_1"/>
    <dbReference type="OMA" id="ELGDAMW"/>
    <dbReference type="OrthoDB" id="5963188at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048476">
        <property type="term" value="C:Holliday junction resolvase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048257">
        <property type="term" value="F:3'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21036">
        <property type="entry name" value="WH_MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20074">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000307">
        <property type="entry name" value="Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000003">
        <property type="entry name" value="Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.110:FF:000001">
        <property type="entry name" value="Putative Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033309">
        <property type="entry name" value="Mus81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047417">
        <property type="entry name" value="WHD_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047416">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451">
        <property type="entry name" value="CLASS II CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451:SF0">
        <property type="entry name" value="CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21136">
        <property type="entry name" value="WHD_MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 14 17" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="16">
        <location>
            <begin position="338"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="80"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="250"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="250"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU369042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGS18669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="629" mass="71166" checksum="D8EAAF858BF28BA2" modified="2011-10-19" version="1">MPTQSDEDCANPLLLKWVKEWWDMARERNTKGIITYKHAYDSLKACPIAFEHPASLVQLRGFGPKLCERLTEKLRQYCEENGLPMPPHPMTKRKRDQRTVPPDLLNDGIDQDDGAPQPKKQRKQRAYVPAYRSGAYAILMALSGIDQHAGMTKSQLIEAAQPYCDASFTTPSDPTKFYTAWNSMKVLQQKELVYEKGRPLKKYCLTDEGWEIAMKIRETDVPKAGSNGTSAGATSTATSSAAAASTSAKATASSSKSLSNSGRTPAVLSTLPKYEPPTLPPKPEVIDLDGDDEDIRSVKKEGMSEYFNVVKNGTTVPTDSELPRFTPIRLMPGTFTVELLLDVREIRAVSDRDYMQQELAKLGVKTTVRSLELGDALWIARCKQPGWLSREGAEGDEVVLDWIVERKRLDDLIESIKDGRFHEQKFRLRRSGIQNVIYIVEEITMDPTHFQKYEEAVESAIASMQVVNGYFLKRTQKMDETIRYLADMTKMLKQLYESKPLHVIPTAVLTTKNYLPLMKHLRQTQPSLSHHISYPAFMSLASKSENMMLRDLFLKMLMCTKGLTGEKAIEIQKVWKTPYNFVKAFERCGQGEDGKQRREEMVMTRLSHLVGRKKISKGLSQMISATWGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>G0SDV1</accession>
    <name>G0SDV1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0053090</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988045">
        <property type="protein sequence ID" value="EGS18702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006695647.1">
        <property type="nucleotide sequence ID" value="XM_006695584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SDV1"/>
    <dbReference type="GeneID" id="18259347"/>
    <dbReference type="KEGG" id="cthr:CTHT_0053090"/>
    <dbReference type="HOGENOM" id="CLU_2454531_0_0_1"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS18702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="89" mass="9364" checksum="F709F6DC37A831AA" modified="2011-10-19" version="1">MDQGSRFANVPSSPSLRLFSGAKLVPVDSTATARPQHPAHRPGAAQSALPALTRRRNTFGEKPDAPDASSSAHLSSVQPLAIPLDDNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G0SE01</accession>
    <name>G0SE01_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex component Sec8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0061930</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC8 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696509.1">
        <property type="nucleotide sequence ID" value="XM_006696446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SE01"/>
    <dbReference type="STRING" id="759272.G0SE01"/>
    <dbReference type="GeneID" id="18260231"/>
    <dbReference type="KEGG" id="cthr:CTHT_0061930"/>
    <dbReference type="eggNOG" id="KOG3691">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004025_0_0_1"/>
    <dbReference type="OMA" id="HMEVRCR"/>
    <dbReference type="OrthoDB" id="272977at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039682">
        <property type="entry name" value="Sec8/EXOC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007191">
        <property type="entry name" value="Sec8_exocyst_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048630">
        <property type="entry name" value="Sec8_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20652">
        <property type="entry name" value="Sec8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04048">
        <property type="entry name" value="Sec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec8 N-terminal" evidence="6">
        <location>
            <begin position="84"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component Sec8 middle helical bundle" evidence="7">
        <location>
            <begin position="335"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="905"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1049"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="906"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="919"/>
            <end position="930"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS18178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1126" mass="125931" checksum="8518E9C0137AC081" modified="2011-10-19" version="1">MSGRYQPYRAGGYGNLSRPDDDYDSYGEGYVSASERYRQQASRAATSSSSSLRPVAPAAAPPPRSAQRPGTSSSHQESNAEREMAKVLELIKQEWPAMLENDCIPVQLALQLLDTSSVGRAHEYRNFQRAHQYLQDSLKKIVHEYHQGFNSSIGTFHKIQGSIQTSQKKVRALKESLAASKAALCATDPELKKLHATSRMYEEVLRTLDELDELRTVPDQLEARISEKRFLTAVGVLQNALRRLTRPELEDIGALSDLRSYLANQETALMDILVEELHEHLYLKSPYCQERWQNLAKCQGALSEAFKDAPAMPPFHAVLDSMDWDRPVTEDPHKNPEADTFYYITLLVESLNKLGKLETAVDTIKQRLPVELFSVVNETIDDIDQKHPSSLRGSSGSHGLHIYGQRETRMRADVIYDLLWTLYGKFEAIAECHRVFHEAIKALIRREGAGNNIALLGSFKELWNLYQNEIRSLLHNYVTTDADVYHFRSSTRPGLGLGLNGKSDSARDHLFRFAEADSKSPEMVAEYEALDNIIRNAVPGLTSNARKNNGDGRKTVLVVPRSDLAGSRKGFAGYGSQQGSGTYKSLVEPSVFNMSLLLPPTLVFLQRLKSIVPPGSDLATSTLTSFLDNFLVNVFQPQLDETLGKLSDTVFGETDAFLQDPDWARVAKRPVFKGATAFFTIVTAFCRMLGTIPHDQALSSLIITQMMRYYDRCFSWYKALVTKSQAEQDGSASNSPQALRASARIALEQCDMHDMVQELWDQEKTGDPELLEKETEMLISMAKEKPLQNSDIIQDRDTISSLCLLYTSMKWLSVKIQGLRFITGNDTDSSRAPTPGPVKRRWTLLNDPNKATSEGGPVYLPMTLETVQSFDGILASLTTLATTALHTLHLELRFRILHSLSSILTPNPPTSSPTPTTPSPSSTSSQNPTPYLLRPPVTITDPDPQILSLNADLIAFDETFSRLLRGCDREVSFLRDGLALLVGEYLIANAPRVAPMNLMGCERMLLNVRVLQQNLRNVEGEKADLGRVNGYFELFCRGPEGILERARGDGELQQQQQSEGDGEGQRKRGRKEIVPGRWKYSYDELKALMELCFSEQLADPEKGVAAAARRQMADRLLGLSEYMWQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G0SE12</accession>
    <name>G0SE12_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0062040</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat ELP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696520.1">
        <property type="nucleotide sequence ID" value="XM_006696457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SE12"/>
    <dbReference type="STRING" id="759272.G0SE12"/>
    <dbReference type="GeneID" id="18260242"/>
    <dbReference type="KEGG" id="cthr:CTHT_0062040"/>
    <dbReference type="eggNOG" id="KOG1063">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006430_0_0_1"/>
    <dbReference type="OMA" id="ENFRHIS"/>
    <dbReference type="OrthoDB" id="27911at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000400">
        <property type="entry name" value="Elongator acetyltransferase complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037289">
        <property type="entry name" value="Elp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="57"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="220"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="304"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="412"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="541"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGS18189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="858" mass="93350" checksum="AD7BE5E8DF4D00D0" modified="2011-10-19" version="1">MAQDNARDIVQSRYLSAGANRYAWAADWGDDGIVAFGSDTNVCLWNPSNSAGISHILSGHTAHVRAVRFVPKADGDQFSYLITGSDDKSLRVWAINSRDAGASCVQTVQEHTEPINCIAVLRVPGFGNGLGSRSIVATGAADATVKIWTLDPTTGQLALLQTIRTVKRYMPLAVAFYPLNKQGTEVILAVAGTTNVVHIYTSSTVDGDAPVTEFTLQATLPGHENWIRSLDFIREKKEAGSDLLLASASQDKYIRLWRIHQGSPLSALSSTGLDLSVDSLMPGQKLHKVTAGSTKYCIMFEALLLGHEDWIYTARWSRSPSSNKLQLLSASADNTLAIWEADPDSGIWLTIARMGEVSREKGATTATGSIGGFWTGLWSPSGTTVITLGRTGSWRRWDYDPNEDTWKQHFAVSGHTRAVTGISWSPDGVYLLSASSDQTTRLHAEWTRGGEGSDNSWHEMARPQIHGYDLNCIGTLSNTSFVSGADEKLMRVFTEPKAVAQMLARLTDASPEAANAAPDAANIPVLGLSNKAVEVVDDSADPTAPLPAQDTVIDPSNPLTSREDAFDPATTIRASALAISHPPFEESLSRHTLWPEIEKLYGHGYELSCLATSHDGGVIASACKASSLNHAVIRLFETKTWTEVKPPLAAHSLTVTKVRFSYPDDRLLLSVGRDRQWVVFERESDEEANGAKKYKYKQIQANAKGHSRMILDCAWAPVVRLGEDGNETRLFATAGRDRSVKLWIRRAGEGEFVQAAAIPQEHPVTALDFVPEFTEDGLILLAVGTEAGRLLVVSLKVVSGEEGKGDVEIVSTLNVPAKLCLPKAVMQLAWRPRRERQKGRELAIAGEDGSLRIYRFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0SE23</accession>
    <name>G0SE23_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Malic enzyme-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0062150</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696531.1">
        <property type="nucleotide sequence ID" value="XM_006696468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SE23"/>
    <dbReference type="STRING" id="759272.G0SE23"/>
    <dbReference type="GeneID" id="18260253"/>
    <dbReference type="KEGG" id="cthr:CTHT_0062150"/>
    <dbReference type="eggNOG" id="KOG1257">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011405_2_1_1"/>
    <dbReference type="OMA" id="YPNMVVQ"/>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05312">
        <property type="entry name" value="NAD_bind_1_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000182">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF32">
        <property type="entry name" value="NADP-DEPENDENT MALIC ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="8">
        <location>
            <begin position="355"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="7">
        <location>
            <begin position="545"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="78"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="193"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="79"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS18200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="846" mass="93381" checksum="EE34AC18EE71DA07" modified="2011-10-19" version="1">MGKSGMSRLALLASQRAGVQKLLKQLAPSNRRAGQTIQISWTLTKALLASSSFDSPFLSSATVRRSLTFAEGRNNHSINTDFTDTSTSTGTNTLSNHLRHSSSSTPTATATPAPTTATTRLTPQGNPGTLLERLVQPCLDHVGPVALALPPWIYTFVILARLPLLLLFLSFPLPPASLSLLSIAGPAMASYASSTSSSPSTDISTPRSRSPSSVASARSSHSSISSSKRMSISSSRRIFAANPMASVDIEAIEEAMRMAKLDTLRGYAQNNYAEVKQLCQTEYIPKHQALGYQILNEPMWNKGLSFTPEQRIAKNLTGLIPHVMEDAERQCERALKMIRTRQTNIDKYLYLSSLKRENIDLFYRLLIDNAKELMPLVYTPTIGDVCLQYSTLYTRPEALYISIKQRKSMKTILRNWPYPNPEICVVTDGSRILGLGDLGVNGVGIPIGKLALYVAAAGIHPEKTLPIVLDCGTNNETNLKDPLYLGLRAKRPSVAEQQEFMDEFMEACREVYPDMVVQFEDFESEKAFNYLDRYRNSYKCFNDDIQGTGAVVLAGYIGAVNLSNVPIEEQRLVFMGAGSAGVGVAKQLVEYYTKRGLSEQQAKDKFYLVDTKGLVTKDRGDKLAEHKKYFARTDNNGRQFRTLEEVIEYVKPTALIGLTATHGVFTESVVRALKASVDGGGHGRRPILFPLSNPLSKAECTFEQAVDWTDGTVIFASGSPFSQYTKNVGDVEVTYYPNQGNNVYVFPGIGLGAILAKASRVTDNMIYTSAAALAGTLNADEIRKGLIYPRIERVRESSLVVAREVMKAARRDGVSQLDESLWQQFEEWGDPALDKWIKDRIYNPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G0SE48</accession>
    <name>G0SE48_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0062410</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696556.1">
        <property type="nucleotide sequence ID" value="XM_006696493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SE48"/>
    <dbReference type="GeneID" id="18260279"/>
    <dbReference type="KEGG" id="cthr:CTHT_0062410"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_8_0_1"/>
    <dbReference type="OMA" id="GNYFMRY"/>
    <dbReference type="OrthoDB" id="3066029at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000354">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF64">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="514"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="558"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="581"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="193"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS18225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="628" mass="68302" checksum="CB94EF1513ABE2BF" modified="2011-10-19" version="1">MTTPSEGCQEADSKISGLDKGEHPGQDPAVDSSSFRKGGSADSPSLSRDWGKDGSQARERSQSRPRTRSRSRNSDRHQSLYSSSSEFGSQQATAISAPAPVISATSKPELDLEKGQPQPEVYRAIIVTPPPSPPEQAADASDHPITIRAKDDDAVPPDPHPPAPLLLEPTLSAPPEIPDSAYDRFPRHRKIIMVALLSFCSFLAPVSSTSVLAATPEVASEYGTTGSVVNVVNAIYMLMMGVSPVVWGPLSQVYGRRRVTAVLFFGCSIGTALAPNLAAFFVFRVLTAFEGTAFILVGSACIGDIYRPTERATALGWFLSGTLIGPALGPFIGGIIVTYTSWRVIFWLQTGLSGLAALFTLTPLLPETIYYRRADELAGFSRRQQARILWSLINPIRVLRLFVYPNLLLASLASSAVIWNMYGLLTPIRYVLNPRFNLTTPMQSGLFYLAPGTGYLVGTLIGGRYADHVVKRWIKKRGGVRVPEDRLRSALPFMGVIIPGCVLVYGWGVQKEAGGIPLAVVTLFVQGVAQLFCFPSLNTYCLDVMQGRGAEVIAGNYFVRYLFACAATACVLPAVEGIGVGWFSTITAVFLIASSAGIAATVRWGNDWKQWVDNKRRERRRARRKHMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G0SEK9</accession>
    <name>G0SEK9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CTHT_0064110</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696717.1">
        <property type="nucleotide sequence ID" value="XM_006696654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SEK9"/>
    <dbReference type="EMDB" id="EMD-15397"/>
    <dbReference type="STRING" id="759272.G0SEK9"/>
    <dbReference type="GeneID" id="18260449"/>
    <dbReference type="KEGG" id="cthr:CTHT_0064110"/>
    <dbReference type="eggNOG" id="KOG0178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_4_3_1"/>
    <dbReference type="OMA" id="YVLNDNM"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03752">
        <property type="entry name" value="proteasome_alpha_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000009">
        <property type="entry name" value="Proteasome subunit alpha type-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGS18386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="251" mass="27946" checksum="9C25D1EFD3C9DF42" modified="2011-10-19" version="1">MARRYDSRTTIFSPDGRLYQVEYALEAISHAGTAIGILAKDGIVLAAERKVTSKLLEQDTSAEKLYVINDNMICAVAGMTADANILINFARQVAQRYLLTYNEDIPCEQLVRRLCDLKQGYTQHGGLRPFGVSFIYAGWDPQREFQLYLSNPSGNYGGWKATSSGANHASAQSLLKQDYKEDCTLEEACDLAVKVLSKTMDATKLSSDKIEFATVGKTKDGKIYHKLWSAEEITALLKKHDLAKDETTEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G0SF54</accession>
    <name>G0SF54_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0060850</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696401.1">
        <property type="nucleotide sequence ID" value="XM_006696338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SF54"/>
    <dbReference type="GeneID" id="18260123"/>
    <dbReference type="KEGG" id="cthr:CTHT_0060850"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_0_1"/>
    <dbReference type="OMA" id="FGMSIQQ"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF49">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="528"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="561"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="589"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="262"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="131"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="753"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="769"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS18070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="797" mass="85715" checksum="A05927D2083262B9" modified="2011-10-19" version="1">MAEEHVPVRWVRWHPYAHSNADGATDAGSIIYLPVLDDGGPLSAGASDTESAGAAYRNGSLNIEAQVRLLMFLTNPNNNLEGSPVTPPSDEVLMASPIAPLTPELAEGASPVPQTTTVQASIVSRTLRSSPPTVPILAHPVPRGAQPVQTPDRHISFSIPRKPIGSTPKKFVRPPSPYPGKPAPIDYKKWEEKFKALQELQEQEIRDQHKAKKPLRAYLPWNPRNTSLTTLLPPKTINATGTINKPNTEERTYVTGLPLIFIIVALMLAIFLMSLDRTIISTAIPYITHEFHSTPHIGWYGSSYLLTACTFQPMFGRIFTLFEVKKAYLLALGVFMLGSLICGIAFNSTTLIVGRAIAGFGSAGITTGSFVVVAEAVPLQSRPIFMALVGLMFGVGATAGPFLGGFFTDFATWRWCFFINLPIGAVTAIALACFFRSKPSKHSGQSIKKRIASLDITGNILLTSASVMLFLALSFTSQGRAWSNKSVVALLIGCFFTALAFVLVQWFKQERALMPPRILNQRTVSASCGMALMTYGALINMTFFLPVWFQAIKGVTATRSGVYMIPYFVVNGLFSILAGIFVSKIGYTTPPAVVGSAVGTVGVSLITLLRPETSTLQWVGYQIVLSAGFGMSIQQGFTSVQTVLVGDDVSIGTAAVISSQSLGGALFLSIGNTIFQSRLIKASSQHLIDIDVKELIDGGAAAFRNLVPPDKLPTVLKIYNKALTDVFTMSIPLGILSALMACFIEWKSVKKPAAKDQESGDGTIIGVENVNSNASSDENGIRNENASSENSGTENNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFF7</accession>
    <name>G0SFF7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0061880</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2019" name="Nucleic Acids Res." volume="47" first="468" last="479">
            <title>Structural analysis of fungal CENP-H/I/K homologs reveals a conserved assembly mechanism underlying proper chromosome alignment.</title>
            <authorList>
                <person name="Hu L."/>
                <person name="Huang H."/>
                <person name="Hei M."/>
                <person name="Yang Y."/>
                <person name="Li S."/>
                <person name="Liu Y."/>
                <person name="Dou Z."/>
                <person name="Wu M."/>
                <person name="Li J."/>
                <person name="Wang G.Z."/>
                <person name="Yao X."/>
                <person name="Liu H."/>
                <person name="He X."/>
                <person name="Tian W."/>
            </authorList>
            <dbReference type="PubMed" id="30407575"/>
            <dbReference type="DOI" id="10.1093/nar/gky1108"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 1-229</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-I/CTF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988046">
        <property type="protein sequence ID" value="EGS18173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696504.1">
        <property type="nucleotide sequence ID" value="XM_006696441.1"/>
    </dbReference>
    <dbReference type="PDB" id="5Z07">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.30 A"/>
        <property type="chains" value="A=1-229"/>
    </dbReference>
    <dbReference type="PDB" id="5Z08">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.20 A"/>
        <property type="chains" value="A/B=1-229"/>
    </dbReference>
    <dbReference type="PDBsum" id="5Z07"/>
    <dbReference type="PDBsum" id="5Z08"/>
    <dbReference type="AlphaFoldDB" id="G0SFF7"/>
    <dbReference type="SMR" id="G0SFF7"/>
    <dbReference type="STRING" id="759272.G0SFF7"/>
    <dbReference type="GeneID" id="18260226"/>
    <dbReference type="KEGG" id="cthr:CTHT_0061880"/>
    <dbReference type="eggNOG" id="ENOG502QU9H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023256_0_0_1"/>
    <dbReference type="OMA" id="RVFKNYY"/>
    <dbReference type="OrthoDB" id="6347512at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000939">
        <property type="term" value="C:inner kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22647">
        <property type="entry name" value="CTF3_NTD_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012485">
        <property type="entry name" value="CENP-I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48208">
        <property type="entry name" value="CENTROMERE PROTEIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48208:SF2">
        <property type="entry name" value="CENTROMERE PROTEIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07778">
        <property type="entry name" value="CENP-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9 10" id="KW-0002">3D-structure</keyword>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS18173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="5Z07"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="5Z08"/>
        </source>
    </evidence>
    <sequence length="683" mass="76203" checksum="CFE55A657274C29B" modified="2011-10-19" version="1">MVNTEEDGLPRLIDAIEEASKIPAKRRQTPIKPTIEKLTTHLYTHGASPDSLLRLADLLTLRNHLDQASLAAITRNLYPSSTVSDEVVLRFIGALGHGQLKPTLALQALFLRWLVMVYHLLENPGVLGQVYGVLFDLLDTAAIRPQLCHLLALVTRRKHVRPFRIQAILTLSRQTGGDPNLTGLLRVFKNYYPEIIVGDATKGRASAFKHPDPQWRQHLDEIQQRRSEAQEDGVRNGFSVNHALGRRLRGTKAVLPTVHTFHAQENSITLEEIDNAEAFVKNLEKFELPTQLVAVLADPLLQKLLLLRPSAEASSRISSWLMACLGDVVSGDADIELLLDMVEVIRDYVIATKGFPPLLLTFFEQFLHIWDDLSPLLNLLETTLLDNTPSSQLSLLTFYHRLLLHWTTLLLSSPDPGQYPAGTSIPQLISHVNKLALTLSQTSPTVHTHLSILDFYASCANLYSNPALLSHISITIPHPLLVYNLYFSPSLAVVSRLCGILAMYKRAWEAVMASPSSSSSGSGSTVKRQLTKHERAQVNDFNGFLMDLCNCLWRGRAFTTTDLNARGCLLPQSVQTVLEKYVRAVDSEMSLAVVFGLSYAPTLCLQAISFMRELEDEDESVQARHAGPVTQASLARLARRGGLELSWQDYRVGVLEYLEAKGFGGIKELMYNTMKNLMKERRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFJ6</accession>
    <name>G0SFJ6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SRP9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CTHT_0071070</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697379.1">
        <property type="nucleotide sequence ID" value="XM_006697316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SFJ6"/>
    <dbReference type="STRING" id="759272.G0SFJ6"/>
    <dbReference type="GeneID" id="18261145"/>
    <dbReference type="KEGG" id="cthr:CTHT_0071070"/>
    <dbReference type="eggNOG" id="ENOG502SRXX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096859_0_0_1"/>
    <dbReference type="OMA" id="YETNKGA"/>
    <dbReference type="OrthoDB" id="5419752at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039914">
        <property type="entry name" value="SRP9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039432">
        <property type="entry name" value="SRP9_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834:SF12">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05486">
        <property type="entry name" value="SRP9-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP9" evidence="2">
        <location>
            <begin position="5"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGS17761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="204" mass="21892" checksum="1C909E465EFD8EA0" modified="2011-10-19" version="1">MPTYEKSEDWLYQSALLLQARPTTTRITTRYSLTPARRIPKKKFTDATQQEQEQQEQQQQQQQQQQQQPLPEQQKPPRGHLILKTYDPVSGTVLKYKTSKAAEVGRLIQMLGSLAKRMGGVDLSTPVRATTTTASTAAGAGAGAAAGETKKDGDGDAVMTDVKVEEGAAGEGGVVSGRSGTQTPVPGQEGGKQGGKGRKKKGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G0SFN9</accession>
    <name>G0SFN9_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pre-mRNA-splicing factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0071530</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="11 12 13" key="2">
        <citation type="journal article" date="2025" name="Cell Res." volume="35" first="296" last="308">
            <title>Structural insights into spliceosome fidelity: DHX35-GPATCH1- mediated rejection of aberrant splicing substrates.</title>
            <authorList>
                <person name="Li Y."/>
                <person name="Fischer P."/>
                <person name="Wang M."/>
                <person name="Zhou Q."/>
                <person name="Song A."/>
                <person name="Yuan R."/>
                <person name="Meng W."/>
                <person name="Chen F.X."/>
                <person name="Luhrmann R."/>
                <person name="Lau B."/>
                <person name="Hurt E."/>
                <person name="Cheng J."/>
            </authorList>
            <dbReference type="PubMed" id="40016598"/>
            <dbReference type="DOI" id="10.1038/s41422-025-01084-w"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.80 ANGSTROMS)</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Belongs to the 40S cdc5-associated complex (or cwf complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWF11 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697422.1">
        <property type="nucleotide sequence ID" value="XM_006697359.1"/>
    </dbReference>
    <dbReference type="PDB" id="9L5R">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="Y=1-1416"/>
    </dbReference>
    <dbReference type="PDB" id="9L5S">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="Y=1-1416"/>
    </dbReference>
    <dbReference type="PDB" id="9L5T">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.50 A"/>
        <property type="chains" value="Y=1-1416"/>
    </dbReference>
    <dbReference type="EMDB" id="EMD-62841"/>
    <dbReference type="EMDB" id="EMD-62842"/>
    <dbReference type="EMDB" id="EMD-62843"/>
    <dbReference type="SMR" id="G0SFN9"/>
    <dbReference type="STRING" id="759272.G0SFN9"/>
    <dbReference type="GeneID" id="18261191"/>
    <dbReference type="KEGG" id="cthr:CTHT_0071530"/>
    <dbReference type="eggNOG" id="KOG1806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001195_0_0_1"/>
    <dbReference type="OMA" id="YRVWLDC"/>
    <dbReference type="OrthoDB" id="1879at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17935">
        <property type="entry name" value="EEXXQc_AQR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000507">
        <property type="entry name" value="Pre-mRNA-splicing factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048966">
        <property type="entry name" value="Aquarius_b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048967">
        <property type="entry name" value="Aquarius_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032174">
        <property type="entry name" value="Aquarius_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026300">
        <property type="entry name" value="CWF11_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF5">
        <property type="entry name" value="RNA HELICASE AQUARIUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16399">
        <property type="entry name" value="Aquarius_N_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21143">
        <property type="entry name" value="Aquarius_N_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21144">
        <property type="entry name" value="Aquarius_N_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038901">
        <property type="entry name" value="AQR_cwf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="11 12 13" id="KW-0002">3D-structure</keyword>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA helicase aquarius N-terminal" evidence="6">
        <location>
            <begin position="62"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="RNA helicase aquarius beta-barrel" evidence="7">
        <location>
            <begin position="475"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="RNA helicase aquarius insertion" evidence="8">
        <location>
            <begin position="686"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="4">
        <location>
            <begin position="789"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="5">
        <location>
            <begin position="1097"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="732"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1374"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1385"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1405"/>
            <end position="1416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR038901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS17804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="9L5R"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="9L5S"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="9L5T"/>
        </source>
    </evidence>
    <sequence length="1416" mass="160837" checksum="FDF0FFF1FA96E92E" modified="2011-10-19" version="1">MPPAKRIKSSADSRPNAGASGRPTLEDLEGENQFTNLARQHWLNVPQQAAKIKVKTDVLKRELYLWPGYGEDSSNYHVLLIILIVNAKRRERVSTWDIFADRPADFSDLFRRALSMTLDSSLSWTIRTHVLLFIIHAFQSLDYAIVRKECAPLVSISIWHNLSTEEKREALLDSNPHLRKAWRAATKRFESADDATKARLRFDRAWLYSLVLDFLTLLYSGNAKQEHVLYCERFVEFLTDLQSQLPTRRYVNTLLQDLHVLPALSLSPIYNDEGNGLLRELCNLFTHYTYFAVDDQSGVQLSREQAYDRHCAILAKLQRIAMKHFKEKLTVLALSNYGSIDKRSELEPLLQALTDDELVQLSNLMNIRTSYPDAARIPVDRKFIVEVLLTTFERRKTFQDAAQALSVLPTEETLFDISLKRTDQYDGSRPLALPKLNLQYLSVGDFLWRSFVLYRCESFYAIRQDLEDALIRLKPEVRRGGVTGFAGFSKMALPISKPVILDVMPPQVGDDKPSCVKAEVTIDLRRLTPQIRRDWESLRPDDVVFLLAVDASRQKQSANGGAVLSEAERLGLVHVRAAEIIQVLDDKGKAIRDPQAYFDGHTRSDIRKIQLRLDATSYKADTEANRNVYEDINLIVRRSSRENNFKPVLESIQDLTLSEVPLASWLHEVFLGYGDPAGATFKQLPNRLKKINFRDTFLDWQHLVESFPGKIIEPSDDVSSSFGPPYVLESVEKQVEEHPSKPSKKRRRDVEPALMSKVETLKVSTYKPPNNGPYPVDAPKLNKIRFTPTQIDAIYSGTQPGLTIIVGPPGTGKTDVAVQIISNIYHNFPEQKTLLVAHSNQALNQLFAKIVALDIDERHLLRLGHGEEELETEGSFSKHGRVESFLDNRQRFLYEVSRLAASMGAPGAHGNSAETAGYFNKVYVEPAWAKFNDIIQREDVGPEDIVRAFPFHAYFSDAPQPLFPPEADRETVLEIANGCYRHISKIFEELADVLPFEILRRDKDKANYLLTSEARIIAMTSTHAAMKRGEIASLGFQYDNVIMEEAAQITEIENFIPLALQKPKNGQMALQRVVLCGDHYQNSPVIQGLAFRHYANLEQSLFSRLVRLGVPTINLDQQGRARPSISNLYRWRYPQLGDLPHTQTEPEFLTANAGFRYDYQFVNVPDYRGMGESEPTPHFIQNLGEAEYAVAIFQYMRLLGYPASKISILATYAGQKALIKDVLAHRCAKNPIFGLPRVVTTVDKYQGEQNDYIILSLTRTTRVGYLRDLRRLTVALSRARLGLYILGRRAVFESCYELRDAFSLLLRRPDKLALVTGELWPSKRLLADETDDTKKLEGEVVMEGVEHLGQWVFEMTKTKIAELRKEKGLSEEVPVEMPKEVVSAEADEGYLPLDEEEGDGEEGEGERVKGFEIEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGA9</accession>
    <name>G0SGA9_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cholestenol delta-isomerase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0065670</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696866.1">
        <property type="nucleotide sequence ID" value="XM_006696803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGA9"/>
    <dbReference type="STRING" id="759272.G0SGA9"/>
    <dbReference type="GeneID" id="18260605"/>
    <dbReference type="KEGG" id="cthr:CTHT_0065670"/>
    <dbReference type="eggNOG" id="KOG4826">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072128_1_0_1"/>
    <dbReference type="OMA" id="VYLWLYL"/>
    <dbReference type="OrthoDB" id="5415655at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047750">
        <property type="term" value="F:cholestenol delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007905">
        <property type="entry name" value="EBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207:SF1">
        <property type="entry name" value="EMOPAMIL-BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207">
        <property type="entry name" value="STEROL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="8">
        <location>
            <begin position="44"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS17248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="245" mass="27727" checksum="3FFABE4939A070EB" modified="2011-10-19" version="1">MTYTLPSEPTLDSTTLFSLLSTVAILIAALALSRVVLPSNMATRWRFLFVWHAFDALIHFILEGSFIYHCYFSVAPVPKDGSLYWPDPENYLGSGLTARFRKIHGPQAAPQNALANLWIVYARADRRWAGVDLTVLSIETITVLFAGSLACFVCYDIARRNPRASLSAIILAVAEIYGGYMTFMPEWLSGNINLDTSNWMYKWLFLTFFNGLWVVVPLYSIYVAADDIFEAFRVRQATLGRKKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGB3</accession>
    <name>G0SGB3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0065710</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696870.1">
        <property type="nucleotide sequence ID" value="XM_006696807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGB3"/>
    <dbReference type="STRING" id="759272.G0SGB3"/>
    <dbReference type="GeneID" id="18260609"/>
    <dbReference type="KEGG" id="cthr:CTHT_0065710"/>
    <dbReference type="eggNOG" id="KOG0714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017633_0_0_1"/>
    <dbReference type="OMA" id="MPIRKEG"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006413">
        <property type="term" value="P:translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000136">
        <property type="entry name" value="DnaJ domain-containing protein Psi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000002">
        <property type="entry name" value="Dnaj homolog subfamily b member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000013">
        <property type="entry name" value="DnaJ subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051339">
        <property type="entry name" value="DnaJ_subfamily_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078:SF553">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="154"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS17252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="374" mass="41070" checksum="929BBBD52769C3A7" modified="2011-10-19" version="1">MVKETKLYDLLNISPNATQDEIKKAYRKAALKWHPDKNKDNPQAAEKFKEVSQAYEILSDPEKRKIYDQFGLEFILRGGPAPDAGGTGPHPFAGGMPEGFSFFNMGGAPGGASFHFSTGPGGGGFAFSDPEEVLRRAFGGTNIFDDLFGGAAGRASGSGGPRARASRSSFGADTMRDAFGGGTDSARGTRASTPEVTTVERPLPVTLEELFHGTTKKMRIKRKLFDETGKRRMDEIILEVNIEKGLRKGTKIRFKGVGDQEEGGRQDLAFVIEEKPHPLFVRDKEDLYHTIDLSLKEALTGWHRTITTIDGKQLPIEKTGITQPGSQDVYPGLGMPASKKRSSTNARGNFIVKYNVKFPTELTEEQKKKLREIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGE1</accession>
    <name>G0SGE1_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rab small monomeric GTPase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CTHT_0065990</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="14034" last="14034">
            <title>Architecture and mechanism of the late endosomal Rab7-like Ypt7 guanine nucleotide exchange factor complex Mon1-Ccz1.</title>
            <authorList>
                <person name="Kiontke S."/>
                <person name="Langemeyer L."/>
                <person name="Kuhlee A."/>
                <person name="Schuback S."/>
                <person name="Raunser S."/>
                <person name="Ungermann C."/>
                <person name="Kummel D."/>
            </authorList>
            <dbReference type="PubMed" id="28051187"/>
            <dbReference type="DOI" id="10.1038/ncomms14034"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS)</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-06" db="PDB data bank">
            <title>Mechanistic Adaptation of the Metazoan RabGEFs Mon1-Ccz1 and Fuzzy-Inturned.</title>
            <authorList>
                <person name="Wilmes S."/>
                <person name="Toenjes J."/>
                <person name="Drechsler M."/>
                <person name="Ruf A."/>
                <person name="Schaefer J."/>
                <person name="Luerick A."/>
                <person name="Januliene D."/>
                <person name="Apelt S."/>
                <person name="Di Iorio D."/>
                <person name="Wegner S.V."/>
                <person name="Loose M."/>
                <person name="Moeller A."/>
                <person name="Paululat A."/>
                <person name="Kuemmel D."/>
            </authorList>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.00 ANGSTROMS)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696898.1">
        <property type="nucleotide sequence ID" value="XM_006696835.1"/>
    </dbReference>
    <dbReference type="PDB" id="5LDD">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.50 A"/>
        <property type="chains" value="C/F=1-205"/>
    </dbReference>
    <dbReference type="PDB" id="9RS7">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.00 A"/>
        <property type="chains" value="C=1-205"/>
    </dbReference>
    <dbReference type="PDBsum" id="5LDD"/>
    <dbReference type="AlphaFoldDB" id="G0SGE1"/>
    <dbReference type="EMDB" id="EMD-54212"/>
    <dbReference type="SMR" id="G0SGE1"/>
    <dbReference type="STRING" id="759272.G0SGE1"/>
    <dbReference type="GeneID" id="18260637"/>
    <dbReference type="KEGG" id="cthr:CTHT_0065990"/>
    <dbReference type="eggNOG" id="KOG0394">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_10_6_1"/>
    <dbReference type="OMA" id="TSWKDEF"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01862">
        <property type="entry name" value="Rab7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000086">
        <property type="entry name" value="Ras-related small GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF20">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB-7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9 10" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGS17280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="5LDD"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="9RS7"/>
        </source>
    </evidence>
    <sequence length="205" mass="23050" checksum="AB890DF6EDB6F1C2" modified="2011-10-19" version="1">MSSRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSASYKATIGADFLTREVMVDDRQVTMQLWDTAGQERFQSLGVAFYRGADCCVLVFDVNNAKSFDALDSWRDEFLIQASPRDPENFPFVVLGNKIDVEESKRVISTKRAQTFCQSKGGIPYFETSAKEAINVEEAFQVIARNALMQEESEEFSGDFQDPINIHIENERDGCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGK6</accession>
    <name>G0SGK6_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Queuine tRNA-ribosyltransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CTHT_0066670</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696963.1">
        <property type="nucleotide sequence ID" value="XM_006696900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGK6"/>
    <dbReference type="STRING" id="759272.G0SGK6"/>
    <dbReference type="GeneID" id="18260705"/>
    <dbReference type="KEGG" id="cthr:CTHT_0066670"/>
    <dbReference type="eggNOG" id="KOG3909">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_868792_0_0_1"/>
    <dbReference type="OMA" id="CTMCVAP"/>
    <dbReference type="OrthoDB" id="27601at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050852">
        <property type="entry name" value="Queuine_tRNA-ribosyltrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46064">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE ACCESSORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46064:SF1">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE ACCESSORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="tRNA-guanine transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="1">
        <location>
            <begin position="27"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGS17345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="320" mass="34945" checksum="12B77429C030F120" modified="2011-10-19" version="1">MTIDTQTVETASMRFDILKAALCDGTTRLGRLSFAGRATVETPTYIAVTSRGAIPHLTPDNVSKHMNVGGVYMALEDFIERPQAYSKRTPPLYQTPTTQKHTTRLHAFTATPSSITTILSPRRLPAVPSPLGNTSKAISVFTSTGFQPLTIVEYISAAQTLQPDIVIPPSDLTHNDITPNSKRALRMAERTDEWIVDWFASAPATSSTFAPILPIPYSVQWEYVARLAEDYLPTGQLSGLALYDMDVLPDLLSFQPTLGPLPRLVLSNPQTPHQLLRQISLGADVFALPFVNTLSDAGLALTFAFPRPQQQNSPRASSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGM3</accession>
    <name>G0SGM3_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CTHT_0066850</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006696980.1">
        <property type="nucleotide sequence ID" value="XM_006696917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGM3"/>
    <dbReference type="STRING" id="759272.G0SGM3"/>
    <dbReference type="GeneID" id="18260723"/>
    <dbReference type="KEGG" id="cthr:CTHT_0066850"/>
    <dbReference type="eggNOG" id="ENOG502RX7Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011522_0_0_1"/>
    <dbReference type="OMA" id="PFNMTLT"/>
    <dbReference type="OrthoDB" id="5294180at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF12">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="55"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="115"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGS17362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="714" mass="78870" checksum="A15BDC5950ECC5C8" modified="2011-10-19" version="1">MSTASPSHQRQQVKTSQVKMAASTTTTTTKAKTAKVGANDNPKQKTVMHRRSRTGCYTCRLRRKKCDEAAPICTACRHLGLVCEYKRPMWWSNNDLRRKTKEEIKMIIKRKKLSDKSSHTIQTSVGTPPGLSHSLPTSATFSGPMDRTRSASIDSHFGFNFNSPPSTADFGPFTPPQVTPEFMFPYPYEIDVKTERQMFIDDVQTLHESTTATYSYAVPPPPGVIPPFPLVGEWTEQVYSERRESLATTEETVDLSYFDAGATTTTTTTTTKQLAIELDEGDQRLLDHFIKFVLPMLFPILEATQTGSTASDLILPSLQTNKAYLHVCLSIAAQHYKQTMGLTGEAATQIDNDIMNHRSSAIAMLVDALNRDEDHQQILEAALGFIFFQRVVGRLEDSLSDVAWHQHFQAVIALVQKLDLPRLVSDPNEPLTQAPFGMTLTAWVDILGATFLSSPPVFAHTYRTKHLSPTNPFLGLRELMGCEDRVMYLISEIACLEALKKNGMDDMTIIQHAHTLGEQINITELYSAEMATAIPSLSRNITAAYRLAARIYLCSLIPGFHPTQGSCIQLVDKLVAVLRQIPAGPTGFDRSLSWVYLIGGSVALAGSPFRAFLEERVALMGDLANIGSFGRVATLLREVWAQQDVLMAQQAAVQSVVGSPRASPPPVTTTMEAPQQQTVGQTAVAGTSALAPASQPYVHWRDVMQMKGWDYLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGT4</accession>
    <name>G0SGT4_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative sorbitol utilization protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0067490</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697041.1">
        <property type="nucleotide sequence ID" value="XM_006696978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGT4"/>
    <dbReference type="STRING" id="759272.G0SGT4"/>
    <dbReference type="GeneID" id="18260787"/>
    <dbReference type="KEGG" id="cthr:CTHT_0067490"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="OMA" id="VAITYER"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF13">
        <property type="entry name" value="L-XYLULOSE REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS17423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="288" mass="31365" checksum="14D0E3D964031A22" modified="2011-10-19" version="1">MTDARGLFPHNTTSPPTTTRVFQLFSLRGKTAVVSGASSGIGLAAAQAFAEAGANVVIWYKSRREMAEQAAREIEEEFGVKCRAYQVDVTSYEAVISALEEQLKEFNNRLDVFVANSGIPWTQGPMLDGELSHYHDVIRTNLDGVFHCARAAGLLFRQQKEQYPQTFDPPFTSGSFIATASMSGHIVNVPQLQAAYNASKAAVVHLCKSLAVEWTGFARANSISPGYINTTISKFCSQEMKEAWKDKIPMGREGEPHELKGAYLYLASDASSYTTGADIVVDGGYCAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G0SGV6</accession>
    <name>G0SGV6_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcineurin subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Calcineurin regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Protein phosphatase 2B regulatory subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CTHT_0067720</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Composed of a catalytic subunit (A) and a regulatory subunit (B).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the calcineurin regulatory subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697063.1">
        <property type="nucleotide sequence ID" value="XM_006697000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SGV6"/>
    <dbReference type="STRING" id="759272.G0SGV6"/>
    <dbReference type="GeneID" id="18260810"/>
    <dbReference type="KEGG" id="cthr:CTHT_0067720"/>
    <dbReference type="eggNOG" id="KOG0034">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061288_10_1_1"/>
    <dbReference type="OMA" id="DTNFDRD"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050801">
        <property type="term" value="P:monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000047">
        <property type="entry name" value="Calcineurin subunit B type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45942">
        <property type="entry name" value="PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01697">
        <property type="entry name" value="PARVALBUMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="21"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="90"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="131"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGS17445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="174" mass="19661" checksum="6E88275E99D65214" modified="2011-10-19" version="1">MGNTTSQVLDNIVQGSNFDREEVDRLRKRFMKLDKDSSGTIDREEFLSLPQISSNPLATRMIAIFDEDGGGDVDFQEFVSGLSAFSSKGNKEQKLRFAFKVYDIDRDGYISNGELFIVLKMMVGNNLKDQQLQQIVDKTIMEADQDGDGKISFEEFCRMVESTDLVASMTLENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G0SH01</accession>
    <name>G0SH01_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CTHT_0068180</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697108.1">
        <property type="nucleotide sequence ID" value="XM_006697045.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0SH01"/>
    <dbReference type="GeneID" id="18260856"/>
    <dbReference type="KEGG" id="cthr:CTHT_0068180"/>
    <dbReference type="eggNOG" id="ENOG502QUGT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001441_0_0_1"/>
    <dbReference type="OMA" id="FMIQMKS"/>
    <dbReference type="OrthoDB" id="5408934at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056416">
        <property type="entry name" value="DH_2_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056222">
        <property type="entry name" value="PH_23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056223">
        <property type="entry name" value="PH_24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24340">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24344">
        <property type="entry name" value="PH_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24345">
        <property type="entry name" value="PH_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DBL homology" evidence="2">
        <location>
            <begin position="1011"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="1214"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="1599"/>
            <end position="1748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="981"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1352"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="1570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1820"/>
            <end position="1864"/>
        </location>
    </feature>
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        <location>
            <begin position="21"/>
            <end position="57"/>
        </location>
    </feature>
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            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="195"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
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            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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        </location>
    </feature>
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        <location>
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            <end position="1422"/>
        </location>
    </feature>
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            <begin position="1510"/>
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        </location>
    </feature>
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        <location>
            <begin position="1522"/>
            <end position="1539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1547"/>
            <end position="1558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1842"/>
            <end position="1855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGS17490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="2029" mass="223086" checksum="775A613188A8AAE2" modified="2011-10-19" version="1">MSPAQQEETAPAAKSDSSQCAAAVNHATASATTPTTKRASAQAKPRPKSAPAAPNRASTHKRKQPEPSLLVDFFLGRPSPARVAAQREAWKQRRKSISADAAHVREELRQEMRAAAMRRLQQPGRVADKVLAWQKKNAEAMKAYGGGVPRAEDAATEPTEVAVNLSPASVTEEDRMRIGGRDKVKKKKPMTGAAGEKDKENQSAGEKTEGNGQSSKARLPSNRSSQSSIPLVVKTAPKKRIVSDDHWMKRGQSKTTPSASSPAKPKVQAKPAPIPKDFLKRTAQNPSVQSKIRDWAQRLETSTTSPPPPRVRECCRKKSADKMALSENSSSSAVTSDTESTKTPEAKVDNGKVKTAKPTTSKSDVDDGIRVKPLMASKSKPDINDRIRVTPVFEKEQKGSNPNPRPMQSTASDDGIRVRALDDPKSGDGIRVQPLDPSSEDDKSVEKFMEKDIAGSKASKKVPTKKTADKLRQKKETEQGFKKPSQSMPGRKSPIEKTADVPTTKEKPVEGKTTTTTVKSSEAKPFKEAAEKRLAKQKSVERKAPYSSSKTTPVERNSSPSRPASTPKSSGQNILESNVEDETPVKRRPSRRHSRRRPRSPSPARREEGLHEKQHRESYSDLSGDESDRVPPTILGNKSLPEIPFGSSAFSVLDLSLGTDPQQTKKPKPQRTPSLKAVPKVIKKVVAGAKEILQESLEPPRPPPTANKPQTIESWLNSTVDPFVDAASPPTVEPIEREAKAEPTKPTPEAVKPPIGLEKRPPSRAQQDSRQHEAALSTTPKPGQSREKVSVQSEDHEATTSTTKTTQTPQSVGLRRSKATRKPTIPTKPATKNPLRDFLKEAFSGESGKHKFSPTEYHSCEADKQSAYLESDWDSTEEPQRRPGPAQSDYSSAYGSTLSSETSSHPPPRRRPPTNGIHELSTIASEEPRSVATFETASDVSQSTITRTTAVAKPTEVSRQRSQKCGLKRRLTKHSDLVSVLSHLDDGHPPARSRSARSSRSIRRKPSKASRQKADDLLEDFADDEYYYGKELKTLVDGVIPVLLRDIMNGDFGGTKADVTAKSVVNMGMTLEKLKNSHKQVPLADLDELFVWLDNISSIYDHYFDVWRLGFHGIIINLAPRLKNPKDNDSLLEAVSWNEDGDVIMETGERVDVAFLLKRPLVRVKWIVKFLKAAVEVTGSSEARRLVGVYEDLQQKARKRYREETARMMDEDANNTDTTRCRDLRTLFPLEGVVVNKLRQVVALDVFELDLRHSSGQRLECRVELIFRDNPALPSDKGDILIREIGNGTRSWLLFPPVPRQYISARRDDDGRSLTAMIRGTHNGIEWYELLKFSSTSEEQIDYWLNVLGTHPLPPTTRSRPVSMVVEPSPSKPDGLPVDIPVGERRLHQSRTETREDPQTHPQHDSQPAKGSSTSPLKTVPSQHPPQAPRPGSTPIQSLESSPIDIDTPRLARPTPNSTPYRADGAPPPPIHRTLGPLNSGLLVPPVDFAFRTRLRRKTSSPLKHEYHPSDVSSESSSSLSSDEDDVRPDDDDDSDEVSSETSESSSSEDELEDDEIPDTIPGYSIKEDSNPAATVFSENTILPEHSASQVAGAADRDQAQTEPDIQRFVASVSYWSSRKGVWKDINDGQPASILVHPGCMEVHVFDEQHAIRQAYQLQTSSLSRTANTDKEAPLILLVLTPVVMIRRSTAVDLEVRSPASPESRLKIDATMFRFRAANLVEAKDLYDAVHFSRLNNSRYIQLSEEARVRAFGQMHAQGEEDSMDGDNSSHRRSWFGRKNSYRASARAPSVSQGSLSTTISAGSFLRRLLGGGNNSFNIDESSIDRQSHPASHGGPGLCTPSGYSLSGTNISPPRSVSLSGSGKSLSQSIQSRLSNGFGRSPDNPFLIRCHLNVANNRWLDKGDCILHISRPPPGVRQELSLYNGLEKRIVVTHATKKQKKGVIGGNDEGTPLILLDAVLGSKCFSMLGSKGIMCSVWENLRDEEGNIGVAPRNGAIAGRVTKWCFQCKSGQQAQWIMGLLTAEVPGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G0SH07</accession>
    <name>G0SH07_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Peptide hydrolase</fullName>
            <ecNumber evidence="15">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CTHT_0068250</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in vacuolar sorting and osmoregulation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Vacuole membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the peptidase M28 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="15"/>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697114.1">
        <property type="nucleotide sequence ID" value="XM_006697051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SH07"/>
    <dbReference type="STRING" id="759272.G0SH07"/>
    <dbReference type="GeneID" id="18260863"/>
    <dbReference type="KEGG" id="cthr:CTHT_0068250"/>
    <dbReference type="eggNOG" id="KOG2194">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006412_1_0_1"/>
    <dbReference type="OMA" id="TPWPVTI"/>
    <dbReference type="OrthoDB" id="76293at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03875">
        <property type="entry name" value="M28_Fxna_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000057">
        <property type="entry name" value="Vacuolar membrane protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048024">
        <property type="entry name" value="Fxna-like_M28_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053975">
        <property type="entry name" value="PFF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053976">
        <property type="entry name" value="PFF1_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF58">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22250">
        <property type="entry name" value="PFF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22251">
        <property type="entry name" value="PFF1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <keyword evidence="10 15" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="531"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="556"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="718"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="753"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="783"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="18">
        <location>
            <begin position="174"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar membrane protease transmembrane" evidence="20">
        <location>
            <begin position="464"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar membrane protease C-terminal" evidence="19">
        <location>
            <begin position="811"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="624"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="630"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF22250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF22251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EGS17496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1039" mass="115739" checksum="B31B4D0246AAE55E" modified="2011-10-19" version="1">MANPFSFRPGQVTFWTTLVYLALLIPIIIINEAPPPSPRNTESPLPGINLTQAWLDLTTITRAYHPYNSHYNEVVRGYLLKRVREILEGNGVAWNIDGAQSSDSNPAVTVFDDTTSNCTFLMESSVVPGTHAPQVAAYFEGTNILVYVRGKLDDKGSWWKTAGPRNFGHVEKGLTLVNAHYDSVSTGYGATDDGMGVVTCLQLIQYFTTPDHQPDRGIVILLNNGEEDWLYGARAFGQHPLLPYIHTFLNLEGAGAGGRANLFRTTDREVTAAYAGSPHPFGTVIASDAFGLGFIRSGTDYSVLYNVYGQRGLDLAFFKPRARYHTNQDDARHASLGSLWHMLSAAVHTTSRLSSNAMGNRFVGPRPDGARNKVRNGRPSDGVWFDLFGKGFVLFGLRGMFAWSLTLLVTTPLILMFISYVLHRVDKYYLFSSRADDVRGHAADDDGHGLGDEPVFLGGWKGFFRFPFAMLVSGSLTLGSALLMKKVNPFIVYGNQYTVWAMMVSLFYFSFWAIMRGANFARPSALHRTYVQVWLFVIGWAILVAVTVSEDRLKIAAGYVFVFLQSSLFLTLFIALCEMFALPKKAIWAAHIREARQNQQAHDFLQGQTSIGEHSPLPTVLRQEQGLSPRGSNHPASPHTNNRDNTDDDVEAELPTERTPLVGGNIGGVEQVPTTFATTYRRSISSLVKKARQKYSTQGYEAFEYEQPWSAHLPTWTWLLQFLLLGPFTIVLVAQTGLMLVDAVHQTGADGSNLLLPYLIIFLFTVLLILPLTPFIHRVTHHIPVFLLVVFGSTLVYNLAAFPFSASARYKAYFIQTLTLDNQTNTICYNGIEKPVRKIISTLPSSLGKEVACSPSKREGLVACCYEGSGLPLPKLTQSHASYNKTEWDSYRDLVNINATRLPSLAPDLWRARLEISASNTKACFVEFATPISALKVHGSSAWDDRFGVLPESGIKTLKLWHREWNKTWVVDVEWNGQLEENDGNIFDGQSGGKRRKMMGNGELKTRNRHSNGLHGTVAFWLWEIRFDKLMTITHGAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHD4</accession>
    <name>G0SHD4_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">P-type phospholipid transporter</fullName>
            <ecNumber evidence="4">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CTHT_0069630</name>
    </gene>
    <organism evidence="24">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="4"/>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697241.1">
        <property type="nucleotide sequence ID" value="XM_006697178.1"/>
    </dbReference>
    <dbReference type="STRING" id="759272.G0SHD4"/>
    <dbReference type="GeneID" id="18261001"/>
    <dbReference type="KEGG" id="cthr:CTHT_0069630"/>
    <dbReference type="eggNOG" id="KOG0206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000846_5_1_1"/>
    <dbReference type="OMA" id="WATMATH"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000090">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000172">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF174">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE DNF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="575"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="617"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1418"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1452"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1483"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1526"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="21">
        <location>
            <begin position="272"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="20">
        <location>
            <begin position="417"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="22">
        <location>
            <begin position="1304"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="756"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1007"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1577"/>
            <end position="1710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1763"/>
            <end position="1804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="80"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="152"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="760"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1007"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1584"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1610"/>
            <end position="1633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1638"/>
            <end position="1665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="1781"/>
            <end position="1793"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="15">
        <location>
            <position position="683"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="683"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="683"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="684"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="685"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
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    <feature type="binding site" evidence="17">
        <location>
            <position position="685"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
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        </ligand>
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        <location>
            <position position="848"/>
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        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
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        <location>
            <position position="895"/>
        </location>
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            <name>ATP</name>
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        </ligand>
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        <location>
            <position position="918"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
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            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022967"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EGS17623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="1804" mass="200644" checksum="83EE3DCD266D9D79" modified="2011-10-19" version="1">MAGPGGPPRRSTTEELREQLENIELQQTELPGTPLTAPASLNAQLRAASAAEHPIPIASPALSSASQPLPRASPDRDDPSGSSTPRSPTNTAFPSTNRPLRAQRSQPSVRTPALYTIPSNTPGSSRPEPVSTSHDNDDEDDDEAPTPLRPPPEARLRVSRDDIRDLTPRVSLTRPRQTFDEMRENYQATINSAEKPFILPSQARSWIAKARERQRKLTSGPWLKVQEKGEEVYKKYILEGLLRQKPIPPSKDGRHIPLKPGLARRKPLKDERTGHAYISNFIRSSRYTLWNFLPKQLFFQFSKLANFYFLVIGILQMIPGLSTTGTYTTIGPLIAFVCLSMAKEGYDDYRRYRLDKLENRSYAWVLDPEDRVRMDYALKGKGTAWKNWFRSRRGKKTDESQEEQPTELETVNTGSGDERWSRIEWQDIRVGDIIRLRRDEDVPADIVLIHATGPNGIAYIETMALDGETNLKSKQASPLLAKHCATVEQMMSVEAEVVSEDPNIDLYNFEGRVTVNGETMPLTLNEVVYRGSTLRNTAEAIGLVINTGEECKIRMNANKNVRAKAPEMQSAVNRIVILLVFFVIALSVGCTVGYIIWKDDYENKAWYLDEGSVSLGQIFVAFVIAYNTLIPLSLYVSLEIVKLGQLYFLNDIEMYDPATDTPFVANTTTILENLGQVSYVFSDKTGTLTENNMKFRKMSVAGTAWLHDMDLQREAAKKAAAKQPVRDEHADQPVEKMAVLSPTQRAKHIVDSEMMEEPLVEGRRSESGYRPRMSTASRWKPSAGHPVHHAQPDLHKTEDLLQYIAAKPNAPFSRKARQFILCMALCHTCLPEKTKDGEIKFQAASPDELALVEAAKDLGYLLVDRSAQTITLQVRSPNGGNTATETYEVMDVIEFSSKRKRMSIILRMPDGRLCIFTKGADSVILPRLKQKQLAIQTATAVERRASMRRSVEQEKALIRRQSLQSPRRESLNLMRAAASMDRKGAWRRSAIITDEVDNWISTREEAEGSALDERAREEAAAAGNEAHAPTPRTSFARQRSLDLVRLAVDPLEGLVDEALVLNEGAVFERCFQHVDDFASEGLRTLIFAYRYLDEEVYRKWKAIYLEATTSLVKRQERIEEAAELIEQEYELAGATAIEDKLQQGVPETIDKLRRANVKVWMLTGDKRETAINIAHSARICKPFSEVYILDAALGDLQDRLAMTLTDVARGMVPHSVAVIDGHTLQVVEESETLRVLFYDLVSRVDSVICCRASPSQKANLVKCIRKQNPSAVTLAIGDGANDIAMIQASHVGVGISGREGLQAARIADYSIAQFRFLQRLLFVHGRWNYVRSGKYILGTFWKEVVFYLLQAHYQRFNGYTGTSLFESTSLTVFNTIFTSLPVIIPAIFERDLAAATLLAVPELYTFGQKNKGFNFAQYLGWMAIAAAESVIIFYSVYGLYALAAHWPVEVDLYAVGTLAFSLAVIFINLKLMFLEVHDRSPIILGLMIISMGGWWLWNILLSVLMPNRLGPYPVHDNFLYGFGRKGLWWLVHFAALSALIVLELGVEALRKSIWPTDRDLMREIEHIDGVMEVMKEHAAERGEAGPSSGDDAAAAATGDAGDAVPVAGHNATSLKTIASSVSDGTNTNTNTERPVSEAGPLPSVPAPVLSPTSATAIASTSRTFAPGTPTIPSAQRNSFHGPIRRAGADYPSSNRNSMASPRLSMGEFRDPAYEQQRRSFAIELEKEREKHRRSFAQERRSFAQERLSFVGAGMAERRGSLAAAAVGGEPSPTTTTTGLGVTNGNGNGNGGAQGVRRSFSGLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHE7</accession>
    <name>G0SHE7_CHATD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CTHT_0069760</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697254.1">
        <property type="nucleotide sequence ID" value="XM_006697191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHE7"/>
    <dbReference type="STRING" id="759272.G0SHE7"/>
    <dbReference type="GeneID" id="18261014"/>
    <dbReference type="KEGG" id="cthr:CTHT_0069760"/>
    <dbReference type="eggNOG" id="KOG1715">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086499_0_1_1"/>
    <dbReference type="OMA" id="LEDKWGV"/>
    <dbReference type="OrthoDB" id="250175at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L7/L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_bL12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_bL12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_bL12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_bL12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL12M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="ClpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="Ribosomal protein L7/12, oligomerisation (N-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein bL12 oligomerization" evidence="5">
        <location>
            <begin position="51"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein bL12 C-terminal" evidence="4">
        <location>
            <begin position="121"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGS17636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="188" mass="19831" checksum="CFCFA455581D8ACD" modified="2011-10-19" version="1">MSLSCRYAAQCCARQLRVAPLRASSSFLLQQQQRVARRCNSTEAAAPSNPKIAAIVDQISQLTLLETADLVASLKARLNIPDLPVGGFAVAAPAQGAGGAAAAPAAEEAEEAPAAQEKTLFTLKLQSFDAAAKPKIIKEVKNLLGLSLVDSKKFVESAPKTMKESVPKEEAEKIVAMMKELGAVVVME</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHN1</accession>
    <name>G0SHN1_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kri1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CTHT_0070630</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KRI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL988047">
        <property type="protein sequence ID" value="EGS17720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697338.1">
        <property type="nucleotide sequence ID" value="XM_006697275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHN1"/>
    <dbReference type="STRING" id="759272.G0SHN1"/>
    <dbReference type="GeneID" id="18261101"/>
    <dbReference type="KEGG" id="cthr:CTHT_0070630"/>
    <dbReference type="eggNOG" id="KOG2409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009647_3_0_1"/>
    <dbReference type="OMA" id="WDNYDPR"/>
    <dbReference type="OrthoDB" id="10252032at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018034">
        <property type="entry name" value="Kri1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024626">
        <property type="entry name" value="Kri1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490:SF5">
        <property type="entry name" value="PROTEIN KRI1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490">
        <property type="entry name" value="ZINC FINGER, ZZ TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05178">
        <property type="entry name" value="Kri1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12936">
        <property type="entry name" value="Kri1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kri1-like C-terminal" evidence="3">
        <location>
            <begin position="514"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="130"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="201"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="314"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="412"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="640"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="317"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="412"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="435"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="469"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="653"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="684"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGS17720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008066"/>
        </source>
    </evidence>
    <sequence length="703" mass="80959" checksum="C72AA8B866BF2EDF" modified="2011-10-19" version="1">MAPPAVKGAKGANSAVNGDAADTIPSVPKKPLFDDESSSEEDQEEGGVQLKINEEYARRFEYNKKREELQRLQEKYKGKNILADDDEEEESSESETEDDDAVLMTEELDREISATLQAIRNRDPKIYDKNTVFYTPFDPDKLPTKKEEKPMTLRDYHRERYLSGDVGAEDDKDGEAAGKKTYVQEQEEIKKSIISEINRVAAENNDDEDWSDDDAFIKPVKREEAEKKPTVKLTEEDIANADKNPEEFLEKFMASKAWLPEDKEHNWQAFESDEGEGDDIDLAEEFEHAYNMRFEDPEKSNEFLQTYSRRMAAMRSARKEEISGRKKKRQEEKERKEREKKEREAERARLRKLKIEEASEKLAKIKEAAGIRGKDLKEEEWLKILEDAWDDDKWEEVMQKYFGDEYYNEADEELMSSDEEEGEDGKKKKKKPKKPKWDDDIDIKDIVPDFEDKPPVTLSDEEKTQGEAAEAEQDEESGSDSEDEGPAKKKRKTTKDIKKERIAAKKQAKAELAKIEQLVDTKMELENPRALEKAALKDKKRLGLEDGMPKFRYREVSPESFGLTARDILLAPSDAALNQFAGLKKLATFREPEKKAKDKKRLGKKARLRKWRREVFGKEYEKTGPTYGFEKLLAENGEEAATGANSFKLGKRREKEKSKDKKDKKESGQSGEPGSAHIIDGERKKKRKRSKKNKNKSGEAAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G0SHX3</accession>
    <name>G0SHX3_CHATD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="9">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CTHT_0073690</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)</name>
        <name type="synonym">Thermochaetoides thermophila</name>
        <dbReference type="NCBI Taxonomy" id="759272"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Sordariomycetidae</taxon>
            <taxon>Sordariales</taxon>
            <taxon>Chaetomiaceae</taxon>
            <taxon>Thermochaetoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Cell" volume="146" first="277" last="289">
            <title>Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile.</title>
            <authorList>
                <person name="Amlacher S."/>
                <person name="Sarges P."/>
                <person name="Flemming D."/>
                <person name="van Noort V."/>
                <person name="Kunze R."/>
                <person name="Devos D.P."/>
                <person name="Arumugam M."/>
                <person name="Bork P."/>
                <person name="Hurt E."/>
            </authorList>
            <dbReference type="PubMed" id="21784248"/>
            <dbReference type="DOI" id="10.1016/j.cell.2011.06.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 1495 / CBS 144.50 / IMI 039719</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="9">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with the U3 snoRNA and is associated with the 90S and 40S pre-ribosomes.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="9"/>
    <dbReference type="EMBL" id="GL988048">
        <property type="protein sequence ID" value="EGS17043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006697625.1">
        <property type="nucleotide sequence ID" value="XM_006697562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G0SHX3"/>
    <dbReference type="STRING" id="759272.G0SHX3"/>
    <dbReference type="GeneID" id="18261407"/>
    <dbReference type="KEGG" id="cthr:CTHT_0073690"/>
    <dbReference type="eggNOG" id="KOG0344">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_4_1"/>
    <dbReference type="OMA" id="FRAGEIW"/>
    <dbReference type="OrthoDB" id="360161at2759"/>
    <dbReference type="Proteomes" id="UP000008066">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17957">
        <property type="entry name" value="DEADc_DDX52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044764">
        <property type="entry name" value="DDX52/Rok1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001
[file cut: first 33554432 bytes kept]
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